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DS.d1771
18930149
[ { "id": "DS.d1771.s0", "type": "", "text": [ "Pharmacological stimulation of TRPV1 channels with capsaicin (10 nM) selectively enhanced the frequency of glutamate-mediated spontaneous (sEPSCs) and miniature excitatory postsynaptic currents (mEPSCs) recorded from putative striatal medium spiny neurons." ], "offsets": [ [ 0, 256 ] ] }, { "id": "DS.d1771.s1", "type": "", "text": [ "Consistently, the totality of striatal neurons responded to capsaicin (10 nM or 10 microM) after prevention of desensitization of TRPV1 channels with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA)." ], "offsets": [ [ 257, 482 ] ] }, { "id": "DS.d1771.s2", "type": "", "text": [ "The effects of capsaicin and of PMA were absent after pharmacological or genetic inactivation of TRPV1 channels." ], "offsets": [ [ 483, 595 ] ] }, { "id": "DS.d1771.s3", "type": "", "text": [ "Finally, we provided evidence for anandamide as an endovanilloid substance in the striatum, since genetic inhibition of anandamide degradation resulted in a tonic activation of TRPV1 channels modulating glutamate but not GABA release." ], "offsets": [ [ 596, 830 ] ] } ]
[ { "id": "DS.d1771.s0.e0", "type": "protein", "text": [ "TRPV1" ], "offsets": [ [ 31, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q697L1" }, { "db_name": "UniProt", "db_id": "Q8NER1" } ] }, { "id": "DS.d1771.s0.e1", "type": "compound", "text": [ "capsaicin" ], "offsets": [ [ 51, 60 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1548943" } ] }, { "id": "DS.d1771.s1.e0", "type": "compound", "text": [ "capsaicin" ], "offsets": [ [ 317, 326 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1548943" } ] }, { "id": "DS.d1771.s1.e1", "type": "protein", "text": [ "TRPV1" ], "offsets": [ [ 387, 392 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q697L1" }, { "db_name": "UniProt", "db_id": "Q8NER1" } ] }, { "id": "DS.d1771.s1.e2", "type": "compound", "text": [ "phorbol 12-myristate 13-acetate" ], "offsets": [ [ 444, 475 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4792" }, { "db_name": "PubChem", "db_id": "27924" }, { "db_name": "PubChem", "db_id": "122634" }, { "db_name": "PubChem", "db_id": "22833501" } ] }, { "id": "DS.d1771.s1.e3", "type": "compound", "text": [ "PMA" ], "offsets": [ [ 477, 480 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27924" }, { "db_name": "PubChem", "db_id": "122634" }, { "db_name": "PubChem", "db_id": "22833501" } ] }, { "id": "DS.d1771.s2.e0", "type": "compound", "text": [ "capsaicin" ], "offsets": [ [ 498, 507 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1548943" } ] }, { "id": "DS.d1771.s2.e1", "type": "compound", "text": [ "PMA" ], "offsets": [ [ 515, 518 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "27924" }, { "db_name": "PubChem", "db_id": "122634" }, { "db_name": "PubChem", "db_id": "22833501" } ] }, { "id": "DS.d1771.s2.e2", "type": "protein", "text": [ "TRPV1" ], "offsets": [ [ 580, 585 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q697L1" }, { "db_name": "UniProt", "db_id": "Q8NER1" } ] }, { "id": "DS.d1771.s3.e0", "type": "compound", "text": [ "anandamide" ], "offsets": [ [ 630, 640 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281969" } ] }, { "id": "DS.d1771.s3.e1", "type": "compound", "text": [ "anandamide" ], "offsets": [ [ 716, 726 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5281969" } ] }, { "id": "DS.d1771.s3.e2", "type": "protein", "text": [ "TRPV1" ], "offsets": [ [ 773, 778 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q697L1" }, { "db_name": "UniProt", "db_id": "Q8NER1" } ] } ]
[]
[]
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DS.d1772
18930474
[ { "id": "DS.d1772.s0", "type": "", "text": [ "With the exception of significantly elevated serum prolactin after escitalopram, no effects in the secondary outcome measures were detected." ], "offsets": [ [ 0, 140 ] ] } ]
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[]
[]
[ { "id": "DS.d1772.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1772.s0.e1", "arg2_id": "DS.d1772.s0.e0", "normalized": [] } ]
DS.d1773
18930547
[ { "id": "DS.d1773.s0", "type": "", "text": [ "The cellular response to dsRNA or its synthetic analog polyinosinic-polycytidylic acid (poly I:C) results in IRF-3-, IRF-7- and NF-kB-mediated activation of type 1 IFNs and pro-inflammatory cytokines critical for innate antiviral immune responses." ], "offsets": [ [ 0, 247 ] ] } ]
[ { "id": "DS.d1773.s0.e0", "type": "compound", "text": [ "polyinosinic-polycytidylic acid" ], "offsets": [ [ 55, 86 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "32744" }, { "db_name": "PubChem", "db_id": "274740" } ] }, { "id": "DS.d1773.s0.e1", "type": "compound", "text": [ "poly I:C" ], "offsets": [ [ 88, 96 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "32744" }, { "db_name": "PubChem", "db_id": "213546" }, { "db_name": "PubChem", "db_id": "274740" } ] }, { "id": "DS.d1773.s0.e2", "type": "protein", "text": [ "IRF-3" ], "offsets": [ [ 109, 114 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P70671" }, { "db_name": "UniProt", "db_id": "Q14653" }, { "db_name": "UniProt", "db_id": "Q4JF28" }, { "db_name": "UniProt", "db_id": "Q764M6" }, { "db_name": "UniProt", "db_id": "Q90643" } ] }, { "id": "DS.d1773.s0.e3", "type": "protein", "text": [ "IRF-7" ], "offsets": [ [ 117, 122 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P70434" }, { "db_name": "UniProt", "db_id": "Q92985" } ] } ]
[]
[]
[ { "id": "DS.d1773.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1773.s0.e0", "arg2_id": "DS.d1773.s0.e3", "normalized": [] }, { "id": "DS.d1773.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1773.s0.e1", "arg2_id": "DS.d1773.s0.e2", "normalized": [] }, { "id": "DS.d1773.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1773.s0.e0", "arg2_id": "DS.d1773.s0.e2", "normalized": [] }, { "id": "DS.d1773.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1773.s0.e1", "arg2_id": "DS.d1773.s0.e3", "normalized": [] } ]
DS.d1774
18930565
[ { "id": "DS.d1774.s0", "type": "", "text": [ "Primaquine toxicity is aggravated in people deficient of 6-glucose phosphate dehydrogenase or glutathione synthetase." ], "offsets": [ [ 0, 117 ] ] } ]
[ { "id": "DS.d1774.s0.e0", "type": "compound", "text": [ "Primaquine" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4908" } ] }, { "id": "DS.d1774.s0.e1", "type": "protein", "text": [ "glutathione synthetase" ], "offsets": [ [ 94, 116 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32463" }, { "db_name": "UniProt", "db_id": "P04425" }, { "db_name": "UniProt", "db_id": "P35667" }, { "db_name": "UniProt", "db_id": "P35668" }, { "db_name": "UniProt", "db_id": "P45480" }, { "db_name": "UniProt", "db_id": "P46413" }, { "db_name": "UniProt", "db_id": "P48637" }, { "db_name": "UniProt", "db_id": "P51855" }, { "db_name": "UniProt", "db_id": "P57612" }, { "db_name": "UniProt", "db_id": "P58578" }, { "db_name": "UniProt", "db_id": "P58579" }, { "db_name": "UniProt", "db_id": "P58580" }, { "db_name": "UniProt", "db_id": "P58581" }, { "db_name": "UniProt", "db_id": "P58582" }, { "db_name": "UniProt", "db_id": "P59495" }, { "db_name": "UniProt", "db_id": "P61396" }, { "db_name": "UniProt", "db_id": "P73493" }, { "db_name": "UniProt", "db_id": "Q08220" }, { "db_name": "UniProt", "db_id": "Q5EAC2" }, { "db_name": "UniProt", "db_id": "Q5LYY5" }, { "db_name": "UniProt", "db_id": "Q5M3J8" }, { "db_name": "UniProt", "db_id": "Q65RX0" }, { "db_name": "UniProt", "db_id": "Q6ANW2" }, { "db_name": "UniProt", "db_id": "Q71VZ1" }, { "db_name": "UniProt", "db_id": "Q7M7H8" }, { "db_name": "UniProt", "db_id": "Q7MHK1" }, { "db_name": "UniProt", "db_id": "Q7NF44" }, { "db_name": "UniProt", "db_id": "Q7NQ65" }, { "db_name": "UniProt", "db_id": "Q7TUG9" }, { "db_name": "UniProt", "db_id": "Q7TUK9" }, { "db_name": "UniProt", "db_id": "Q7TVB0" }, { "db_name": "UniProt", "db_id": "Q7U3W8" }, { "db_name": "UniProt", "db_id": "Q7VY62" }, { "db_name": "UniProt", "db_id": "Q7W910" }, { "db_name": "UniProt", "db_id": "Q7WKF5" }, { "db_name": "UniProt", "db_id": "Q82V16" }, { "db_name": "UniProt", "db_id": "Q82ZG8" }, { "db_name": "UniProt", "db_id": "Q83AL0" }, { "db_name": "UniProt", "db_id": "Q83Q91" }, { "db_name": "UniProt", "db_id": "Q87D42" }, { "db_name": "UniProt", "db_id": "Q87LK1" }, { "db_name": "UniProt", "db_id": "Q87VA4" }, { "db_name": "UniProt", "db_id": "Q88D35" }, { "db_name": "UniProt", "db_id": "Q88UW5" }, { "db_name": "UniProt", "db_id": "Q89WL0" }, { "db_name": "UniProt", "db_id": "Q8D335" }, { "db_name": "UniProt", "db_id": "Q8DCA9" }, { "db_name": "UniProt", "db_id": "Q8DKF1" }, { "db_name": "UniProt", "db_id": "Q8DW15" }, { "db_name": "UniProt", "db_id": "Q8DXM9" }, { "db_name": "UniProt", "db_id": "Q8E399" }, { "db_name": "UniProt", "db_id": "Q8EIK8" }, { "db_name": "UniProt", "db_id": "Q8FE30" }, { "db_name": "UniProt", "db_id": "Q8FXW6" }, { "db_name": "UniProt", "db_id": "Q8HXX5" }, { "db_name": "UniProt", "db_id": "Q8K931" }, { "db_name": "UniProt", "db_id": "Q8P6P1" }, { "db_name": "UniProt", "db_id": "Q8PHZ5" }, { "db_name": "UniProt", "db_id": "Q8UII5" }, { "db_name": "UniProt", "db_id": "Q8XK30" }, { "db_name": "UniProt", "db_id": "Q8Y3R3" }, { "db_name": "UniProt", "db_id": "Q8YE82" }, { "db_name": "UniProt", "db_id": "Q926X7" }, { "db_name": "UniProt", "db_id": "Q92SN3" }, { "db_name": "UniProt", "db_id": "Q98DE8" }, { "db_name": "UniProt", "db_id": "Q9ABS9" }, { "db_name": "UniProt", "db_id": "Q9CM00" }, { "db_name": "UniProt", "db_id": "Q9I697" }, { "db_name": "UniProt", "db_id": "Q9JTJ6" }, { "db_name": "UniProt", "db_id": "Q9JYJ3" }, { "db_name": "UniProt", "db_id": "Q9KUP7" }, { "db_name": "UniProt", "db_id": "Q9PC29" } ] } ]
[]
[]
[ { "id": "DS.d1774.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1774.s0.e0", "arg2_id": "DS.d1774.s0.e1", "normalized": [] } ]
DS.d1775
18930648
[ { "id": "DS.d1775.s0", "type": "", "text": [ "Levels of interleukin-8 (IL-8) and 8-isoprostane were measured in epithelial lining fluid (ELF) from central and peripheral airways separately collected using a bronchoscopic microsampling technique." ], "offsets": [ [ 0, 199 ] ] } ]
[ { "id": "DS.d1775.s0.e0", "type": "protein", "text": [ "interleukin-8" ], "offsets": [ [ 10, 23 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10145" } ] }, { "id": "DS.d1775.s0.e1", "type": "protein", "text": [ "IL-8" ], "offsets": [ [ 25, 29 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62812" }, { "db_name": "UniProt", "db_id": "P08317" }, { "db_name": "UniProt", "db_id": "P10145" }, { "db_name": "UniProt", "db_id": "P19874" }, { "db_name": "UniProt", "db_id": "P26894" }, { "db_name": "UniProt", "db_id": "P36925" }, { "db_name": "UniProt", "db_id": "P41324" }, { "db_name": "UniProt", "db_id": "P46653" }, { "db_name": "UniProt", "db_id": "P49113" }, { "db_name": "UniProt", "db_id": "P67813" }, { "db_name": "UniProt", "db_id": "P67814" }, { "db_name": "UniProt", "db_id": "P79255" }, { "db_name": "UniProt", "db_id": "Q102R3" }, { "db_name": "UniProt", "db_id": "Q7YRB5" }, { "db_name": "UniProt", "db_id": "Q9XSX5" } ] }, { "id": "DS.d1775.s0.e2", "type": "compound", "text": [ "8-isoprostane" ], "offsets": [ [ 35, 48 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "107873" } ] } ]
[]
[]
[]
DS.d1776
18930650
[ { "id": "DS.d1776.s0", "type": "", "text": [ "Fluoroimmunoassay based on the fluorescent property of quantum dot was used along with immunoassay to detect 2,4-D. CdTe capped with mercaptopropionic acid, was conjugated using N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC) and a coupling reagent like N-hydroxysuccinimide (NHS) to alkaline phosphatase (ALP) which was in turn conjugated to 2,4-D molecule." ], "offsets": [ [ 0, 376 ] ] } ]
[ { "id": "DS.d1776.s0.e0", "type": "compound", "text": [ "N-hydroxysuccinimide" ], "offsets": [ [ 272, 292 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "80170" } ] }, { "id": "DS.d1776.s0.e1", "type": "protein", "text": [ "alkaline phosphatase" ], "offsets": [ [ 302, 322 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] }, { "id": "DS.d1776.s0.e2", "type": "protein", "text": [ "ALP" ], "offsets": [ [ 324, 327 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03973" }, { "db_name": "UniProt", "db_id": "P12547" }, { "db_name": "UniProt", "db_id": "P22298" }, { "db_name": "UniProt", "db_id": "P28296" }, { "db_name": "UniProt", "db_id": "P29118" }, { "db_name": "UniProt", "db_id": "P35211" }, { "db_name": "UniProt", "db_id": "P83610" }, { "db_name": "UniProt", "db_id": "P97430" }, { "db_name": "UniProt", "db_id": "Q03420" }, { "db_name": "UniProt", "db_id": "Q53GG5" }, { "db_name": "UniProt", "db_id": "Q9H0A0" }, { "db_name": "UniProt", "db_id": "Q9PU47" }, { "db_name": "UniProt", "db_id": "Q9Z1X0" } ] } ]
[]
[]
[ { "id": "DS.d1776.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1776.s0.e0", "arg2_id": "DS.d1776.s0.e2", "normalized": [] }, { "id": "DS.d1776.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1776.s0.e0", "arg2_id": "DS.d1776.s0.e1", "normalized": [] } ]
DS.d1777
18930705
[ { "id": "DS.d1777.s0", "type": "", "text": [ "The SoxN protein is proposed to harbor the heme b of lower reduction potential and the heme a (s), and CbsA the other heme b." ], "offsets": [ [ 0, 125 ] ] } ]
[ { "id": "DS.d1777.s0.e0", "type": "compound", "text": [ "heme a" ], "offsets": [ [ 87, 93 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5326705" }, { "db_name": "PubChem", "db_id": "5942915" } ] }, { "id": "DS.d1777.s0.e1", "type": "protein", "text": [ "CbsA" ], "offsets": [ [ 103, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54088" }, { "db_name": "UniProt", "db_id": "P58029" } ] } ]
[]
[]
[]
DS.d1778
18930712
[ { "id": "DS.d1778.s0", "type": "", "text": [ "Seleno-L-methionine (SeMet) can be oxidized to L-methionine selenoxide (MetSeO) by flavin-containing monooxygenase 3 (FMO3) and rat liver microsomes in the presence of NADPH." ], "offsets": [ [ 0, 174 ] ] } ]
[ { "id": "DS.d1778.s0.e0", "type": "protein", "text": [ "FMO3" ], "offsets": [ [ 118, 122 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31513" }, { "db_name": "UniProt", "db_id": "P32417" }, { "db_name": "UniProt", "db_id": "Q7YS44" }, { "db_name": "UniProt", "db_id": "Q8HYJ9" }, { "db_name": "UniProt", "db_id": "Q8SPQ7" }, { "db_name": "UniProt", "db_id": "Q95LA1" } ] }, { "id": "DS.d1778.s0.e1", "type": "compound", "text": [ "NADPH" ], "offsets": [ [ 168, 173 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5884" } ] } ]
[]
[]
[ { "id": "DS.d1778.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1778.s0.e1", "arg2_id": "DS.d1778.s0.e0", "normalized": [] } ]
DS.d1779
18930714
[ { "id": "DS.d1779.s0", "type": "", "text": [ "Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells." ], "offsets": [ [ 0, 140 ] ] }, { "id": "DS.d1779.s1", "type": "", "text": [ "Using various biochemical, pharmacological and molecular biological approaches, we have recently reported regulatory roles for Rac1, a small G-protein, in glucose-stimulated insulin secretion (GSIS)." ], "offsets": [ [ 141, 340 ] ] }, { "id": "DS.d1779.s2", "type": "", "text": [ "GTP-bound form) and membrane association of Rac1 in INS 832/13 cells and rat islets." ], "offsets": [ [ 341, 425 ] ] }, { "id": "DS.d1779.s3", "type": "", "text": [ "Interestingly, however, in contrast to the inhibitory effects of NSC23766, Tiam1 gene depletion potentiated GSIS in these cells; such a potentiation of GSIS was sensitive to extracellular calcium." ], "offsets": [ [ 426, 622 ] ] } ]
[ { "id": "DS.d1779.s0.e0", "type": "protein", "text": [ "Tiam1" ], "offsets": [ [ 21, 26 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q60610" } ] }, { "id": "DS.d1779.s0.e1", "type": "protein", "text": [ "Rac1" ], "offsets": [ [ 69, 73 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P40792" }, { "db_name": "UniProt", "db_id": "P63001" }, { "db_name": "UniProt", "db_id": "Q6RUV5" } ] }, { "id": "DS.d1779.s0.e2", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 78, 85 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1779.s0.e3", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 97, 104 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1779.s1.e0", "type": "protein", "text": [ "Rac1" ], "offsets": [ [ 268, 272 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P40792" }, { "db_name": "UniProt", "db_id": "P63001" }, { "db_name": "UniProt", "db_id": "Q6RUV5" } ] }, { "id": "DS.d1779.s1.e1", "type": "protein", "text": [ "small G-protein" ], "offsets": [ [ 276, 291 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15153" } ] }, { "id": "DS.d1779.s1.e2", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 296, 303 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1779.s1.e3", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 315, 322 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1779.s2.e0", "type": "compound", "text": [ "GTP" ], "offsets": [ [ 341, 344 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6830" } ] }, { "id": "DS.d1779.s2.e1", "type": "protein", "text": [ "Rac1" ], "offsets": [ [ 385, 389 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P40792" }, { "db_name": "UniProt", "db_id": "P63001" }, { "db_name": "UniProt", "db_id": "Q6RUV5" } ] }, { "id": "DS.d1779.s3.e0", "type": "compound", "text": [ "NSC23766" ], "offsets": [ [ 491, 499 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "409805" } ] }, { "id": "DS.d1779.s3.e1", "type": "protein", "text": [ "Tiam1" ], "offsets": [ [ 501, 506 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q60610" } ] } ]
[]
[]
[ { "id": "DS.d1779.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1779.s0.e2", "arg2_id": "DS.d1779.s0.e3", "normalized": [] }, { "id": "DS.d1779.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1779.s1.e2", "arg2_id": "DS.d1779.s1.e3", "normalized": [] } ]
DS.d1780
18930760
[ { "id": "DS.d1780.s0", "type": "", "text": [ "This vector allows the co-expression of alpha-Hb as a fusion protein with Glutathione S-Transferase (GST-alpha-Hb) and beta-Hb with an additional methionine at the N-terminal extremity (rbeta-Hb)." ], "offsets": [ [ 0, 196 ] ] } ]
[ { "id": "DS.d1780.s0.e0", "type": "protein", "text": [ "Glutathione S-Transferase" ], "offsets": [ [ 74, 99 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O04437" }, { "db_name": "UniProt", "db_id": "O18598" }, { "db_name": "UniProt", "db_id": "P0A9D2" }, { "db_name": "UniProt", "db_id": "P0A9D3" }, { "db_name": "UniProt", "db_id": "P30116" }, { "db_name": "UniProt", "db_id": "P44521" }, { "db_name": "UniProt", "db_id": "P46088" }, { "db_name": "UniProt", "db_id": "P46419" }, { "db_name": "UniProt", "db_id": "P46423" }, { "db_name": "UniProt", "db_id": "P46426" }, { "db_name": "UniProt", "db_id": "P46428" }, { "db_name": "UniProt", "db_id": "P46437" }, { "db_name": "UniProt", "db_id": "P48438" }, { "db_name": "UniProt", "db_id": "P80894" }, { "db_name": "UniProt", "db_id": "P81065" }, { "db_name": "UniProt", "db_id": "P82996" }, { "db_name": "UniProt", "db_id": "P82997" }, { "db_name": "UniProt", "db_id": "P82998" }, { "db_name": "UniProt", "db_id": "P82999" }, { "db_name": "UniProt", "db_id": "P83000" }, { "db_name": "UniProt", "db_id": "P83001" }, { "db_name": "UniProt", "db_id": "P83246" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q08392" }, { "db_name": "UniProt", "db_id": "Q08393" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" }, { "db_name": "UniProt", "db_id": "Q96324" } ] }, { "id": "DS.d1780.s0.e1", "type": "protein", "text": [ "GST" ], "offsets": [ [ 101, 104 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20432" }, { "db_name": "UniProt", "db_id": "P30104" }, { "db_name": "UniProt", "db_id": "P30106" }, { "db_name": "UniProt", "db_id": "P30107" }, { "db_name": "UniProt", "db_id": "P30108" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" } ] }, { "id": "DS.d1780.s0.e2", "type": "compound", "text": [ "methionine" ], "offsets": [ [ 146, 156 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "876" }, { "db_name": "PubChem", "db_id": "6137" } ] } ]
[]
[]
[]
DS.d1781
18930779
[ { "id": "DS.d1781.s0", "type": "", "text": [ "Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activities as well as thiobarbituric acid reactive substances (TBARSs) and nitric oxide (NO) levels were analysed in erythrocyte and plasma of rats." ], "offsets": [ [ 0, 228 ] ] }, { "id": "DS.d1781.s1", "type": "", "text": [ "The erythrocyte CAT activity was higher in erdosteine group and there was a statistically significant increase, when compared with the erdosteine plus ischemia/reperfusion group." ], "offsets": [ [ 229, 407 ] ] } ]
[ { "id": "DS.d1781.s0.e0", "type": "protein", "text": [ "Superoxide dismutase" ], "offsets": [ [ 0, 20 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d1781.s0.e1", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 22, 25 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] }, { "id": "DS.d1781.s0.e2", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 28, 36 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": "P29422" }, { "db_name": "UniProt", "db_id": "P30265" }, { "db_name": "UniProt", "db_id": "P30266" }, { "db_name": "UniProt", "db_id": "P32290" }, { "db_name": "UniProt", "db_id": "P42321" }, { "db_name": "UniProt", "db_id": "P44390" }, { "db_name": "UniProt", "db_id": "P45737" }, { "db_name": "UniProt", "db_id": "P45739" }, { "db_name": "UniProt", "db_id": "P55304" }, { "db_name": "UniProt", "db_id": "P55306" }, { "db_name": "UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] }, { "id": "DS.d1781.s0.e3", "type": "protein", "text": [ "CAT" ], "offsets": [ [ 38, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P00485" }, { "db_name": "UniProt", "db_id": "P00486" }, { "db_name": "UniProt", "db_id": "P00487" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P06135" }, { "db_name": "UniProt", "db_id": "P07641" }, { "db_name": "UniProt", "db_id": "P11504" }, { "db_name": "UniProt", "db_id": "P20074" }, { "db_name": "UniProt", "db_id": "P22782" }, { "db_name": "UniProt", "db_id": "P25309" }, { "db_name": "UniProt", "db_id": "P25819" }, { "db_name": "UniProt", "db_id": "P26825" }, { "db_name": "UniProt", "db_id": "P26826" }, { "db_name": "UniProt", "db_id": "P32796" }, { "db_name": "UniProt", "db_id": "P36882" }, { "db_name": "UniProt", "db_id": "P36883" }, { "db_name": "UniProt", "db_id": "P43155" }, { "db_name": "UniProt", "db_id": "P47934" }, { "db_name": "UniProt", "db_id": "P49417" }, { "db_name": "UniProt", "db_id": "P52826" }, { "db_name": "UniProt", "db_id": "P58777" }, { "db_name": "UniProt", "db_id": "P62577" }, { "db_name": "UniProt", "db_id": "P62578" }, { "db_name": "UniProt", "db_id": "P62579" }, { "db_name": "UniProt", "db_id": "P62580" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q00614" }, { "db_name": "UniProt", "db_id": "Q02736" }, { "db_name": "UniProt", "db_id": "Q03058" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q704S8" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PWF7" } ] }, { "id": "DS.d1781.s0.e4", "type": "protein", "text": [ "glutathione peroxidase" ], "offsets": [ [ 48, 70 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d1781.s0.e5", "type": "compound", "text": [ "thiobarbituric acid" ], "offsets": [ [ 102, 121 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2723628" } ] }, { "id": "DS.d1781.s0.e6", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 155, 167 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d1781.s1.e0", "type": "protein", "text": [ "CAT" ], "offsets": [ [ 245, 248 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P00485" }, { "db_name": "UniProt", "db_id": "P00486" }, { "db_name": "UniProt", "db_id": "P00487" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P06135" }, { "db_name": "UniProt", "db_id": "P07641" }, { "db_name": "UniProt", "db_id": "P11504" }, { "db_name": "UniProt", "db_id": "P20074" }, { "db_name": "UniProt", "db_id": "P22782" }, { "db_name": "UniProt", "db_id": "P25309" }, { "db_name": "UniProt", "db_id": "P25819" 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"db_name": "UniProt", "db_id": "Q9PWF7" } ] }, { "id": "DS.d1781.s1.e1", "type": "compound", "text": [ "erdosteine" ], "offsets": [ [ 272, 282 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65632" } ] }, { "id": "DS.d1781.s1.e2", "type": "compound", "text": [ "erdosteine" ], "offsets": [ [ 364, 374 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "65632" } ] } ]
[]
[]
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DS.d1782
18930802
[ { "id": "DS.d1782.s0", "type": "", "text": [ "The ethidium bromide (EB) demyelinating model was associated with vitamin E (Vit E) and ebselen (Ebs) treatment to evaluate acetylcholinesterase (AChE) activity in the striatum (ST), hippocampus (HP), cerebral cortex (CC) and erythrocytes." ], "offsets": [ [ 0, 239 ] ] } ]
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[]
[]
[]
DS.d1784
18930813
[ { "id": "DS.d1784.s0", "type": "", "text": [ "A search of publicly available microarray data reveals that expression of mitochondrial manganese superoxide dismutase (Sod2), responsible for the conversion of superoxide (O(2)(-)) to hydrogen peroxide (H(2)O(2)), is consistently increased in high-grade and advanced-stage bladder tumors." ], "offsets": [ [ 0, 289 ] ] } ]
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[]
[]
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DS.d1785
18930826
[ { "id": "DS.d1785.s0", "type": "", "text": [ "In vivo TASK blockade by anandamide significantly increased infarct volumes at 24 h in mice undergoing 30 min of transient middle cerebral artery occlusion (tMCAO)." ], "offsets": [ [ 0, 164 ] ] } ]
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[]
[]
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DS.d1786
18930833
[ { "id": "DS.d1786.s0", "type": "", "text": [ "Glutathione S-transferases (GSTs) are multifunctional phase II detoxification enzymes that catalyze the attachment of electrophilic substrates to glutathione." ], "offsets": [ [ 0, 158 ] ] } ]
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[]
[]
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DS.d1787
18930846
[ { "id": "DS.d1787.s0", "type": "", "text": [ "It can use a dithiol-disulfide active-site to transfer reducing equivalents from NADPH to thioredoxin (Trx), via the cofactor FAD." ], "offsets": [ [ 0, 130 ] ] } ]
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"UniProt", "db_id": "P46843" }, { "db_name": "UniProt", "db_id": "P47370" }, { "db_name": "UniProt", "db_id": "P50413" }, { "db_name": "UniProt", "db_id": "P52227" }, { "db_name": "UniProt", "db_id": "P75512" }, { "db_name": "UniProt", "db_id": "P82460" }, { "db_name": "UniProt", "db_id": "P99505" }, { "db_name": "UniProt", "db_id": "Q24742" }, { "db_name": "UniProt", "db_id": "Q57755" }, { "db_name": "UniProt", "db_id": "Q5R9M3" }, { "db_name": "UniProt", "db_id": "Q98TX1" }, { "db_name": "UniProt", "db_id": "Q9BDJ3" }, { "db_name": "UniProt", "db_id": "Q9DGI3" }, { "db_name": "UniProt", "db_id": "Q9R6P9" }, { "db_name": "UniProt", "db_id": "Q9X2T1" } ] } ]
[]
[]
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DS.d1788
18930903
[ { "id": "DS.d1788.s0", "type": "", "text": [ "Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that plays an essential role in oxygen homeostasis." ], "offsets": [ [ 0, 122 ] ] } ]
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[]
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DS.d1789
18930948
[ { "id": "DS.d1789.s0", "type": "", "text": [ "However, transferrin, a protein with no active site serine, was covalently modified in vitro by 0.5mM 10-fluoroethoxyphosphinyl-N-biotinamido pentyldecanamide, chlorpyrifos oxon, diisopropylfluorophosphate, dichlorvos, sarin, and soman." ], "offsets": [ [ 0, 236 ] ] } ]
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DS.d1792
18931035
[ { "id": "DS.d1792.s0", "type": "", "text": [ "The mechanism of lysoPAF-mediated inhibition of neutrophils involves an elevation in the intracellular cAMP level, and pharmacological blockade of adenylyl cyclase completely reverses the inhibitory effect of lysoPAF." ], "offsets": [ [ 0, 217 ] ] } ]
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DS.d1793
18931047
[ { "id": "DS.d1793.s0", "type": "", "text": [ "Sympathetic neurogenic Ca2+ signalling in rat arteries: ATP, noradrenaline and neuropeptide Y." ], "offsets": [ [ 0, 94 ] ] } ]
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DS.d1794
18931108
[ { "id": "DS.d1794.s0", "type": "", "text": [ "DnaB (BA) demonstrated a strong DNA helicase activity that required ATP or dATP." ], "offsets": [ [ 0, 80 ] ] } ]
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"Q8B912" }, { "db_name": "UniProt", "db_id": "Q8R979" }, { "db_name": "UniProt", "db_id": "Q8V439" }, { "db_name": "UniProt", "db_id": "Q8V6W7" }, { "db_name": "UniProt", "db_id": "Q8V736" }, { "db_name": "UniProt", "db_id": "Q8ZXT5" }, { "db_name": "UniProt", "db_id": "Q91A29" }, { "db_name": "UniProt", "db_id": "Q91AV2" }, { "db_name": "UniProt", "db_id": "Q91QT2" }, { "db_name": "UniProt", "db_id": "Q96725" }, { "db_name": "UniProt", "db_id": "Q971T7" }, { "db_name": "UniProt", "db_id": "Q975P6" }, { "db_name": "UniProt", "db_id": "Q97ZF5" }, { "db_name": "UniProt", "db_id": "Q97ZZ8" }, { "db_name": "UniProt", "db_id": "Q9IW06" }, { "db_name": "UniProt", "db_id": "Q9PYA3" }, { "db_name": "UniProt", "db_id": "Q9UZ86" }, { "db_name": "UniProt", "db_id": "Q9WJB2" }, { "db_name": "UniProt", "db_id": "Q9YC75" }, { "db_name": "UniProt", "db_id": "Q9YCB6" }, { "db_name": "UniProt", "db_id": "Q9YN02" } ] }, { "id": "DS.d1794.s0.e2", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 68, 71 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d1794.s0.e3", "type": "compound", "text": [ "dATP" ], "offsets": [ [ 75, 79 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "15993" } ] } ]
[]
[]
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DS.d1795
18931130
[ { "id": "DS.d1795.s0", "type": "", "text": [ "MerH was found to transport mercuric ions in Escherichia coli via a pair of essential cysteine residues but only when coexpressed with the mercuric reductase." ], "offsets": [ [ 0, 158 ] ] } ]
[ { "id": "DS.d1795.s0.e0", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 86, 94 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] }, { "id": "DS.d1795.s0.e1", "type": "protein", "text": [ "mercuric reductase" ], "offsets": [ [ 139, 157 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00392" }, { "db_name": "UniProt", "db_id": "P08332" }, { "db_name": "UniProt", "db_id": "P08662" }, { "db_name": "UniProt", "db_id": "P0A0E4" }, { "db_name": "UniProt", "db_id": "P0A0E5" }, { "db_name": "UniProt", "db_id": "P16171" }, { "db_name": "UniProt", "db_id": "P17239" }, { "db_name": "UniProt", "db_id": "P30341" }, { "db_name": "UniProt", "db_id": "P94188" }, { "db_name": "UniProt", "db_id": "P94702" }, { "db_name": "UniProt", "db_id": "Q51772" }, { "db_name": "UniProt", "db_id": "Q52109" }, { "db_name": "UniProt", "db_id": "Q54465" } ] } ]
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DS.d1796
18931136
[ { "id": "DS.d1796.s0", "type": "", "text": [ "HmuY and HmuR are hemin binding proteins required for P. gingivalis growth." ], "offsets": [ [ 0, 75 ] ] } ]
[ { "id": "DS.d1796.s0.e0", "type": "protein", "text": [ "HmuR" ], "offsets": [ [ 9, 13 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q56989" } ] }, { "id": "DS.d1796.s0.e1", "type": "compound", "text": [ "hemin" ], "offsets": [ [ 18, 23 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4971" } ] } ]
[]
[]
[ { "id": "DS.d1796.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1796.s0.e1", "arg2_id": "DS.d1796.s0.e0", "normalized": [] } ]
DS.d1797
18931257
[ { "id": "DS.d1797.s0", "type": "", "text": [ "The effect of tropomyosin on actin filaments was independent of ionic strength, but became stronger as the magnesium concentration increased." ], "offsets": [ [ 0, 141 ] ] } ]
[ { "id": "DS.d1797.s0.e0", "type": "protein", "text": [ "tropomyosin" ], "offsets": [ [ 14, 25 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O01673" }, { "db_name": "UniProt", "db_id": "O02389" }, { "db_name": "UniProt", "db_id": "O16127" }, { "db_name": "UniProt", "db_id": "O18416" }, { "db_name": "UniProt", "db_id": "O44119" }, { "db_name": "UniProt", "db_id": "O61379" }, { "db_name": "UniProt", "db_id": "O96764" }, { "db_name": "UniProt", "db_id": "O97162" }, { "db_name": "UniProt", "db_id": "O97192" }, { "db_name": "UniProt", "db_id": "P31816" }, { "db_name": "UniProt", "db_id": "P91958" }, { "db_name": "UniProt", "db_id": "Q02088" }, { "db_name": "UniProt", "db_id": "Q23758" }, { "db_name": "UniProt", "db_id": "Q23939" }, { "db_name": "UniProt", "db_id": "Q25145" }, { "db_name": "UniProt", "db_id": "Q25456" }, { "db_name": "UniProt", "db_id": "Q25457" }, { "db_name": "UniProt", "db_id": "Q25632" }, { "db_name": "UniProt", "db_id": "Q26503" }, { "db_name": "UniProt", "db_id": "Q26519" }, { "db_name": "UniProt", "db_id": "Q7M3Y8" }, { "db_name": "UniProt", "db_id": "Q8IT89" }, { "db_name": "UniProt", "db_id": "Q8T380" }, { "db_name": "UniProt", "db_id": "Q8T6L5" }, { "db_name": "UniProt", "db_id": "Q8WR63" }, { "db_name": "UniProt", "db_id": "Q95PU1" }, { "db_name": "UniProt", "db_id": "Q95VA8" }, { "db_name": "UniProt", "db_id": "Q9GZ69" }, { "db_name": "UniProt", "db_id": "Q9GZ70" }, { "db_name": "UniProt", "db_id": "Q9GZ71" }, { "db_name": "UniProt", "db_id": "Q9N2R3" }, { "db_name": "UniProt", "db_id": "Q9NAS5" }, { "db_name": "UniProt", "db_id": "Q9NDS0" }, { "db_name": "UniProt", "db_id": "Q9NFZ4" }, { "db_name": "UniProt", "db_id": "Q9NG56" }, { "db_name": "UniProt", "db_id": "Q9UB83" } ] }, { "id": "DS.d1797.s0.e1", "type": "protein", "text": [ "actin" ], "offsets": [ [ 29, 34 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00937" }, { "db_name": "UniProt", "db_id": "O13419" }, { "db_name": "UniProt", "db_id": "O16808" }, { "db_name": "UniProt", "db_id": "O17320" }, { "db_name": "UniProt", "db_id": "O65314" }, { "db_name": "UniProt", "db_id": "O65315" }, { "db_name": "UniProt", "db_id": "O65316" }, { "db_name": "UniProt", "db_id": "O74258" }, { "db_name": "UniProt", "db_id": "O81221" }, { "db_name": "UniProt", "db_id": "P02577" }, { "db_name": "UniProt", "db_id": "P10365" }, { "db_name": "UniProt", "db_id": "P10989" }, { "db_name": "UniProt", "db_id": "P11426" }, { "db_name": "UniProt", "db_id": "P13363" }, { "db_name": "UniProt", "db_id": "P14235" }, { "db_name": "UniProt", "db_id": "P17128" }, { "db_name": "UniProt", "db_id": "P20904" }, { "db_name": "UniProt", "db_id": "P24902" }, { "db_name": "UniProt", "db_id": "P26182" }, { "db_name": "UniProt", "db_id": "P26183" }, { "db_name": "UniProt", "db_id": "P30161" }, { "db_name": "UniProt", "db_id": "P45520" }, { "db_name": "UniProt", "db_id": "P45521" }, { "db_name": "UniProt", "db_id": "P48465" }, { "db_name": "UniProt", "db_id": "P50138" }, { "db_name": "UniProt", "db_id": "P51775" }, { "db_name": "UniProt", "db_id": "P53455" }, { "db_name": "UniProt", "db_id": "P53476" }, { "db_name": "UniProt", "db_id": "P53477" }, { "db_name": "UniProt", "db_id": "P53491" }, { "db_name": "UniProt", "db_id": "P53498" }, { "db_name": "UniProt", "db_id": "P53499" }, { "db_name": "UniProt", "db_id": "P53500" }, { "db_name": "UniProt", "db_id": "P53502" }, { "db_name": "UniProt", "db_id": "P53689" }, { "db_name": "UniProt", "db_id": "P60009" }, { "db_name": "UniProt", "db_id": "P60010" }, { "db_name": "UniProt", "db_id": "P60011" }, { "db_name": "UniProt", "db_id": "P68555" }, { "db_name": "UniProt", "db_id": "P78711" }, { "db_name": "UniProt", "db_id": "P80709" }, { "db_name": "UniProt", "db_id": "P81085" }, { "db_name": "UniProt", "db_id": "P90689" }, { "db_name": "UniProt", "db_id": "P91754" }, { "db_name": "UniProt", "db_id": "Q05214" }, { "db_name": "UniProt", "db_id": "Q11212" }, { "db_name": "UniProt", "db_id": "Q24733" }, { "db_name": "UniProt", "db_id": "Q2U7A3" }, { "db_name": "UniProt", "db_id": "Q39596" }, { "db_name": "UniProt", "db_id": "Q39758" }, { "db_name": "UniProt", "db_id": "Q6TCF2" }, { "db_name": "UniProt", "db_id": "Q75D00" }, { "db_name": "UniProt", "db_id": "Q8SWN8" }, { "db_name": "UniProt", "db_id": "Q8X119" }, { "db_name": "UniProt", "db_id": "Q92192" }, { "db_name": "UniProt", "db_id": "Q92193" }, { "db_name": "UniProt", "db_id": "Q99023" }, { "db_name": "UniProt", "db_id": "Q9P4D1" }, { "db_name": "UniProt", "db_id": "Q9UVF3" }, { "db_name": "UniProt", "db_id": "Q9UVX4" }, { "db_name": "UniProt", "db_id": "Q9UVZ8" } ] }, { "id": "DS.d1797.s0.e2", "type": "compound", "text": [ "magnesium" ], "offsets": [ [ 107, 116 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5462224" } ] } ]
[]
[]
[ { "id": "DS.d1797.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1797.s0.e2", "arg2_id": "DS.d1797.s0.e1", "normalized": [] }, { "id": "DS.d1797.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1797.s0.e2", "arg2_id": "DS.d1797.s0.e0", "normalized": [] } ]
DS.d1798
18931328
[ { "id": "DS.d1798.s0", "type": "", "text": [ "We showed that, compared with the untreated CF serous cells, a 24-hour pre-incubation period with 200 nM salmeterol induced an 83% increase in delF508-CFTR-mediated chloride efflux." ], "offsets": [ [ 0, 181 ] ] } ]
[ { "id": "DS.d1798.s0.e0", "type": "protein", "text": [ "CFTR" ], "offsets": [ [ 151, 155 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13569" }, { "db_name": "UniProt", "db_id": "P26361" }, { "db_name": "UniProt", "db_id": "P26362" }, { "db_name": "UniProt", "db_id": "P26363" }, { "db_name": "UniProt", "db_id": "P34158" }, { "db_name": "UniProt", "db_id": "P35071" }, { "db_name": "UniProt", "db_id": "Q00552" }, { "db_name": "UniProt", "db_id": "Q00553" }, { "db_name": "UniProt", "db_id": "Q00554" }, { "db_name": "UniProt", "db_id": "Q00555" }, { "db_name": "UniProt", "db_id": "Q07DV2" }, { "db_name": "UniProt", "db_id": "Q07DW5" }, { "db_name": "UniProt", "db_id": "Q07DX5" }, { "db_name": "UniProt", "db_id": "Q07DY5" }, { "db_name": "UniProt", "db_id": "Q07DZ6" }, { "db_name": "UniProt", "db_id": "Q07E16" }, { "db_name": "UniProt", "db_id": "Q07E42" }, { "db_name": "UniProt", "db_id": "Q09YH0" }, { "db_name": "UniProt", "db_id": "Q09YJ4" }, { "db_name": "UniProt", "db_id": "Q09YK5" }, { "db_name": "UniProt", "db_id": "Q108U0" }, { "db_name": "UniProt", "db_id": "Q2IBA1" }, { "db_name": "UniProt", "db_id": "Q2IBB3" }, { "db_name": "UniProt", "db_id": "Q2IBE4" }, { "db_name": "UniProt", "db_id": "Q2IBF6" }, { "db_name": "UniProt", "db_id": "Q2QL74" }, { "db_name": "UniProt", "db_id": "Q2QL83" }, { "db_name": "UniProt", "db_id": "Q2QLA3" }, { "db_name": "UniProt", "db_id": "Q2QLB4" }, { "db_name": "UniProt", "db_id": "Q2QLC5" }, { "db_name": "UniProt", "db_id": "Q2QLE5" }, { "db_name": "UniProt", "db_id": "Q2QLF9" }, { "db_name": "UniProt", "db_id": "Q2QLH0" }, { "db_name": "UniProt", "db_id": "Q5D1Z7" }, { "db_name": "UniProt", "db_id": "Q5U820" }, { "db_name": "UniProt", "db_id": "Q6PQZ2" }, { "db_name": "UniProt", "db_id": "Q7JII7" }, { "db_name": "UniProt", "db_id": "Q7JII8" }, { "db_name": "UniProt", "db_id": "Q9TSP5" }, { "db_name": "UniProt", "db_id": "Q9TUQ2" } ] }, { "id": "DS.d1798.s0.e1", "type": "compound", "text": [ "chloride" ], "offsets": [ [ 165, 173 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "312" } ] } ]
[]
[]
[ { "id": "DS.d1798.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1798.s0.e1", "arg2_id": "DS.d1798.s0.e0", "normalized": [] } ]
DS.d1799
18931344
[ { "id": "DS.d1799.s0", "type": "", "text": [ "Activation of Bax and Bak was demonstrated in peripheral blood mononuclear cells, and induction of apoptosis was related to overall obatoclax exposure, as monitored by the plasma concentration of oligonucleosomal DNA/histone complexes." ], "offsets": [ [ 0, 235 ] ] } ]
[ { "id": "DS.d1799.s0.e0", "type": "protein", "text": [ "Bax" ], "offsets": [ [ 14, 17 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P27297" }, { "db_name": "UniProt", "db_id": "Q07813" }, { "db_name": "UniProt", "db_id": "Q63690" } ] }, { "id": "DS.d1799.s0.e1", "type": "protein", "text": [ "Bak" ], "offsets": [ [ 22, 25 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08734" } ] }, { "id": "DS.d1799.s0.e2", "type": "compound", "text": [ "obatoclax" ], "offsets": [ [ 132, 141 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11404337" }, { "db_name": "PubChem", "db_id": "45356963" } ] } ]
[]
[]
[]
DS.d1800
18931380
[ { "id": "DS.d1800.s0", "type": "", "text": [ "Liver glycidamide DNA adducts and acrylamide and glycidamide N-terminal valine hemoglobin adducts were also determined." ], "offsets": [ [ 0, 119 ] ] } ]
[ { "id": "DS.d1800.s0.e0", "type": "compound", "text": [ "glycidamide" ], "offsets": [ [ 6, 17 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "91550" } ] }, { "id": "DS.d1800.s0.e1", "type": "compound", "text": [ "acrylamide" ], "offsets": [ [ 34, 44 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6579" } ] }, { "id": "DS.d1800.s0.e2", "type": "compound", "text": [ "glycidamide" ], "offsets": [ [ 49, 60 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "91550" } ] }, { "id": "DS.d1800.s0.e3", "type": "compound", "text": [ "valine" ], "offsets": [ [ 72, 78 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6287" } ] }, { "id": "DS.d1800.s0.e4", "type": "protein", "text": [ "hemoglobin" ], "offsets": [ [ 79, 89 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15160" }, { "db_name": "UniProt", "db_id": "P17724" }, { "db_name": "UniProt", "db_id": "P73925" }, { "db_name": "UniProt", "db_id": "Q03459" } ] } ]
[]
[]
[ { "id": "DS.d1800.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1800.s0.e3", "arg2_id": "DS.d1800.s0.e4", "normalized": [] } ]
DS.d1801
18931475
[ { "id": "DS.d1801.s0", "type": "", "text": [ "The acyl ghrelin peptide features a unique post-translational modification of O-n-octanoylation at serine 3, and is the only gastrointestinal signal that increases meal size." ], "offsets": [ [ 0, 174 ] ] } ]
[ { "id": "DS.d1801.s0.e0", "type": "protein", "text": [ "ghrelin" ], "offsets": [ [ 9, 16 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q6BEG6" }, { "db_name": "UniProt", "db_id": "Q6BEG7" }, { "db_name": "UniProt", "db_id": "Q9BDJ6" }, { "db_name": "UniProt", "db_id": "Q9BEF8" }, { "db_name": "UniProt", "db_id": "Q9EQX0" }, { "db_name": "UniProt", "db_id": "Q9GKY5" }, { "db_name": "UniProt", "db_id": "Q9QYH7" }, { "db_name": "UniProt", "db_id": "Q9UBU3" } ] }, { "id": "DS.d1801.s0.e1", "type": "compound", "text": [ "serine" ], "offsets": [ [ 99, 105 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5951" } ] } ]
[]
[]
[ { "id": "DS.d1801.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1801.s0.e1", "arg2_id": "DS.d1801.s0.e0", "normalized": [] } ]
DS.d1802
18931618
[ { "id": "DS.d1802.s0", "type": "", "text": [ "Tests of the blood samples obtained at the ED revealed leucocytosis (11 070.6+/-4302.5/microl), increased blood glucose, LDH, CK and CK-MB levels." ], "offsets": [ [ 0, 146 ] ] } ]
[ { "id": "DS.d1802.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 112, 119 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1802.s0.e1", "type": "protein", "text": [ "LDH" ], "offsets": [ [ 121, 124 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29038" }, { "db_name": "UniProt", "db_id": "P33571" }, { "db_name": "UniProt", "db_id": "P93052" }, { "db_name": "UniProt", "db_id": "Q27797" }, { "db_name": "UniProt", "db_id": "Q27888" }, { "db_name": "UniProt", "db_id": "Q95028" }, { "db_name": "UniProt", "db_id": "Q99289" } ] } ]
[]
[]
[]
DS.d1803
18931836
[ { "id": "DS.d1803.s0", "type": "", "text": [ "Molecular and biochemical characterization of a distinct tyrosinase involved in melanin production from Aeromonas media." ], "offsets": [ [ 0, 120 ] ] }, { "id": "DS.d1803.s1", "type": "", "text": [ "TyrA had a relatively higher affinity to diphenol substrate L-dihydroxyphenylalanine (L-dopa) than many other tyrosinases." ], "offsets": [ [ 121, 243 ] ] }, { "id": "DS.d1803.s2", "type": "", "text": [ "EDTA or glutathione notably inhibited the enzymatic activities of TyrA, whereas Triton X-100 and SDS activated them." ], "offsets": [ [ 244, 360 ] ] }, { "id": "DS.d1803.s3", "type": "", "text": [ "These results suggest that TyrA is the first reported distinct tyrosinase involved in melanin production in the genus Aeromonas." ], "offsets": [ [ 361, 489 ] ] } ]
[ { "id": "DS.d1803.s0.e0", "type": "protein", "text": [ "tyrosinase" ], "offsets": [ [ 57, 67 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42713" }, { "db_name": "UniProt", "db_id": "P06845" }, { "db_name": "UniProt", "db_id": "P07524" }, { "db_name": "UniProt", "db_id": "P33180" }, { "db_name": "UniProt", "db_id": "P55022" }, { "db_name": "UniProt", "db_id": "P55023" }, { "db_name": "UniProt", "db_id": "P55033" }, { "db_name": "UniProt", "db_id": "Q00234" }, { "db_name": "UniProt", "db_id": "Q8J130" }, { "db_name": "UniProt", "db_id": "Q92396" } ] }, { "id": "DS.d1803.s0.e1", "type": "compound", "text": [ "melanin" ], "offsets": [ [ 80, 87 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6325610" } ] }, { "id": "DS.d1803.s1.e0", "type": "protein", "text": [ "TyrA" ], "offsets": [ [ 121, 125 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07023" }, { "db_name": "UniProt", "db_id": "P20692" }, { "db_name": "UniProt", "db_id": "P43901" }, { "db_name": "UniProt", "db_id": "P43902" }, { "db_name": "UniProt", "db_id": "Q02287" }, { "db_name": "UniProt", "db_id": "Q9CET9" } ] }, { "id": "DS.d1803.s1.e1", "type": "compound", "text": [ "diphenol" ], "offsets": [ [ 162, 170 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "33665" } ] }, { "id": "DS.d1803.s1.e2", "type": "compound", "text": [ "dihydroxyphenylalanine" ], "offsets": [ [ 183, 205 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "836" } ] }, { "id": "DS.d1803.s1.e3", "type": "compound", "text": [ "L-dopa" ], "offsets": [ [ 207, 213 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6047" } ] }, { "id": "DS.d1803.s1.e4", "type": "protein", "text": [ "tyrosinases" ], "offsets": [ [ 231, 242 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42713" }, { "db_name": "UniProt", "db_id": "P06845" }, { "db_name": "UniProt", "db_id": "P07524" }, { "db_name": "UniProt", "db_id": "P33180" }, { "db_name": "UniProt", "db_id": "P55022" }, { "db_name": "UniProt", "db_id": "P55023" }, { "db_name": "UniProt", "db_id": "P55033" }, { "db_name": "UniProt", "db_id": "Q00234" }, { "db_name": "UniProt", "db_id": "Q8J130" }, { "db_name": "UniProt", "db_id": "Q92396" } ] }, { "id": "DS.d1803.s2.e0", "type": "protein", "text": [ "TyrA" ], "offsets": [ [ 310, 314 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07023" }, { "db_name": "UniProt", "db_id": "P20692" }, { "db_name": "UniProt", "db_id": "P43901" }, { "db_name": "UniProt", "db_id": "P43902" }, { "db_name": "UniProt", "db_id": "Q02287" }, { "db_name": "UniProt", "db_id": "Q9CET9" } ] }, { "id": "DS.d1803.s2.e1", "type": "compound", "text": [ "Triton X-100" ], "offsets": [ [ 324, 336 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5590" } ] }, { "id": "DS.d1803.s3.e0", "type": "protein", "text": [ "TyrA" ], "offsets": [ [ 388, 392 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07023" }, { "db_name": "UniProt", "db_id": "P20692" }, { "db_name": "UniProt", "db_id": "P43901" }, { "db_name": "UniProt", "db_id": "P43902" }, { "db_name": "UniProt", "db_id": "Q02287" }, { "db_name": "UniProt", "db_id": "Q9CET9" } ] }, { "id": "DS.d1803.s3.e1", "type": "protein", "text": [ "tyrosinase" ], "offsets": [ [ 424, 434 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42713" }, { "db_name": "UniProt", "db_id": "P06845" }, { "db_name": "UniProt", "db_id": "P07524" }, { "db_name": "UniProt", "db_id": "P33180" }, { "db_name": "UniProt", "db_id": "P55022" }, { "db_name": "UniProt", "db_id": "P55023" }, { "db_name": "UniProt", "db_id": "P55033" }, { "db_name": "UniProt", "db_id": "Q00234" }, { "db_name": "UniProt", "db_id": "Q8J130" }, { "db_name": "UniProt", "db_id": "Q92396" } ] }, { "id": "DS.d1803.s3.e2", "type": "compound", "text": [ "melanin" ], "offsets": [ [ 447, 454 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6325610" } ] } ]
[]
[]
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DS.d1804
18931932
[ { "id": "DS.d1804.s0", "type": "", "text": [ "AMP-deaminase from goldfish white muscle: regulatory properties and redistribution under exposure to high environmental oxygen level." ], "offsets": [ [ 0, 133 ] ] }, { "id": "DS.d1804.s1", "type": "", "text": [ "Both sodium and potassium ions activated goldfish AMPD at low concentrations, with maximal activation at about 80 mM of each chloride salt, whereas higher concentrations became inhibitory." ], "offsets": [ [ 134, 322 ] ] }, { "id": "DS.d1804.s2", "type": "", "text": [ "Magnesium and calcium ions also inhibited goldfish muscle AMPD, as did phosphate and fluoride ; at a concentration of 8 mM, each anion reduced activity by about 66%." ], "offsets": [ [ 323, 488 ] ] } ]
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[]
[]
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DS.d1805
18931933
[ { "id": "DS.d1805.s0", "type": "", "text": [ "Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A." ], "offsets": [ [ 0, 146 ] ] } ]
[ { "id": "DS.d1805.s0.e0", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 29, 32 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] }, { "id": "DS.d1805.s0.e1", "type": "compound", "text": [ "alpha-lipoic acid" ], "offsets": [ [ 93, 110 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "864" }, { "db_name": "PubChem", "db_id": "6112" } ] }, { "id": "DS.d1805.s0.e2", "type": "protein", "text": [ "PI3 kinase" ], "offsets": [ [ 119, 129 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P42347" }, { "db_name": "UniProt", "db_id": "P42348" }, { "db_name": "UniProt", "db_id": "P54673" }, { "db_name": "UniProt", "db_id": "P54674" }, { "db_name": "UniProt", "db_id": "P54675" }, { "db_name": "UniProt", "db_id": "P54676" } ] }, { "id": "DS.d1805.s0.e3", "type": "protein", "text": [ "PTEN" ], "offsets": [ [ 131, 135 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P60483" }, { "db_name": "UniProt", "db_id": "P60484" } ] }, { "id": "DS.d1805.s0.e4", "type": "protein", "text": [ "PP2A" ], "offsets": [ [ 141, 145 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P23696" }, { "db_name": "UniProt", "db_id": "Q06009" }, { "db_name": "UniProt", "db_id": "Q9ZSE4" } ] } ]
[]
[]
[ { "id": "DS.d1805.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1805.s0.e1", "arg2_id": "DS.d1805.s0.e0", "normalized": [] }, { "id": "DS.d1805.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1805.s0.e1", "arg2_id": "DS.d1805.s0.e3", "normalized": [] }, { "id": "DS.d1805.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1805.s0.e1", "arg2_id": "DS.d1805.s0.e2", "normalized": [] }, { "id": "DS.d1805.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1805.s0.e1", "arg2_id": "DS.d1805.s0.e4", "normalized": [] } ]
DS.d1806
18931946
[ { "id": "DS.d1806.s0", "type": "", "text": [ "Unfolding and inactivation of abalone (Haliotis diversicolor) alkaline phosphatase during denaturation by guanidine hydrochloride." ], "offsets": [ [ 0, 130 ] ] }, { "id": "DS.d1806.s1", "type": "", "text": [ "Unfolding and inactivation of ALPase from abalone (Haliotis diversicolor) during denaturation by guanidine hydrochloride (GuHCl) of different concentrations has first been studied." ], "offsets": [ [ 131, 311 ] ] } ]
[ { "id": "DS.d1806.s0.e0", "type": "protein", "text": [ "alkaline phosphatase" ], "offsets": [ [ 62, 82 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] }, { "id": "DS.d1806.s0.e1", "type": "compound", "text": [ "guanidine hydrochloride" ], "offsets": [ [ 106, 129 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3520" } ] }, { "id": "DS.d1806.s1.e0", "type": "protein", "text": [ "ALPase" ], "offsets": [ [ 161, 167 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P81800" } ] }, { "id": "DS.d1806.s1.e1", "type": "compound", "text": [ "guanidine hydrochloride" ], "offsets": [ [ 228, 251 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3520" } ] } ]
[]
[]
[ { "id": "DS.d1806.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1806.s0.e1", "arg2_id": "DS.d1806.s0.e0", "normalized": [] }, { "id": "DS.d1806.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1806.s1.e1", "arg2_id": "DS.d1806.s1.e0", "normalized": [] } ]
DS.d1807
18931948
[ { "id": "DS.d1807.s0", "type": "", "text": [ "We aim to study a possible benefit of a common nitrogen oxide donor, anti-anginal drug, nicorandil (N-(2-hydroxyethyl) nicotinamide nitrate ester), in managing acute gastric ulcers through studying its effect on some relevant intermediates to ulcerogenesis as lipid peroxidation, tumor necrosis factor-alpha (TNF-alpha), and nitric oxide (NO)." ], "offsets": [ [ 0, 343 ] ] } ]
[ { "id": "DS.d1807.s0.e0", "type": "protein", "text": [ "tumor necrosis factor" ], "offsets": [ [ 280, 301 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8JFG3" } ] }, { "id": "DS.d1807.s0.e1", "type": "protein", "text": [ "TNF-alpha" ], "offsets": [ [ 309, 318 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35734" }, { "db_name": "UniProt", "db_id": "O77510" }, { "db_name": "UniProt", "db_id": "O77764" }, { "db_name": "UniProt", "db_id": "P01375" }, { "db_name": "UniProt", "db_id": "P04924" }, { "db_name": "UniProt", "db_id": "P06804" }, { "db_name": "UniProt", "db_id": "P13296" }, { "db_name": "UniProt", "db_id": "P16599" }, { "db_name": "UniProt", "db_id": "P19101" }, { "db_name": "UniProt", "db_id": "P23383" }, { "db_name": "UniProt", "db_id": "P23563" }, { "db_name": "UniProt", "db_id": "P29553" }, { "db_name": "UniProt", "db_id": "P33620" }, { "db_name": "UniProt", "db_id": "P36939" }, { "db_name": "UniProt", "db_id": "P48094" }, { "db_name": "UniProt", "db_id": "P51435" }, { "db_name": "UniProt", "db_id": "P51742" }, { "db_name": "UniProt", "db_id": "P51743" }, { "db_name": "UniProt", "db_id": "P59684" }, { "db_name": "UniProt", "db_id": "P59693" }, { "db_name": "UniProt", "db_id": "P59694" }, { "db_name": "UniProt", "db_id": "P59695" }, { "db_name": "UniProt", "db_id": "P79337" }, { "db_name": "UniProt", "db_id": "P79374" }, { "db_name": "UniProt", "db_id": "Q06599" }, { "db_name": "UniProt", "db_id": "Q19LH4" }, { "db_name": "UniProt", "db_id": "Q1G1A2" }, { "db_name": "UniProt", "db_id": "Q1WM27" }, { "db_name": "UniProt", "db_id": "Q2MH05" }, { "db_name": "UniProt", "db_id": "Q539C2" }, { "db_name": "UniProt", "db_id": "Q75N23" }, { "db_name": "UniProt", "db_id": "Q8HZD9" }, { "db_name": "UniProt", "db_id": "Q8JFG3" }, { "db_name": "UniProt", "db_id": "Q8MKG8" }, { "db_name": "UniProt", "db_id": "Q8WNR1" }, { "db_name": "UniProt", "db_id": "Q9BEA1" } ] }, { "id": "DS.d1807.s0.e2", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 325, 337 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] } ]
[]
[]
[]
DS.d1808
18932012
[ { "id": "DS.d1808.s1", "type": "", "text": [ "NADH/NAD (+) ratio can be normalized by the activation or overexpression of nicotinamide nucleotide transhydrogenase (NNT--> NADPH+ NAD (+)." ], "offsets": [ [ 0, 143 ] ] } ]
[ { "id": "DS.d1808.s1.e0", "type": "compound", "text": [ "NADH" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439153" } ] }, { "id": "DS.d1808.s1.e2", "type": "protein", "text": [ "nicotinamide nucleotide transhydrogenase" ], "offsets": [ [ 76, 116 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P11024" }, { "db_name": "UniProt", "db_id": "Q13423" }, { "db_name": "UniProt", "db_id": "Q61941" } ] }, { "id": "DS.d1808.s1.e3", "type": "protein", "text": [ "NNT" ], "offsets": [ [ 118, 121 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O93474" }, { "db_name": "UniProt", "db_id": "P11024" }, { "db_name": "UniProt", "db_id": "Q13423" } ] }, { "id": "DS.d1808.s1.e4", "type": "compound", "text": [ "NADPH" ], "offsets": [ [ 128, 133 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5884" } ] }, { "id": "DS.d1808.s1.e5", "type": "compound", "text": [ "NAD" ], "offsets": [ [ 5, 8 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5893" } ] } ]
[]
[]
[ { "id": "DS.d1808.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1808.s1.e4", "arg2_id": "DS.d1808.s1.e3", "normalized": [] }, { "id": "DS.d1808.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1808.s1.e4", "arg2_id": "DS.d1808.s1.e2", "normalized": [] }, { "id": "DS.d1808.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1808.s1.e0", "arg2_id": "DS.d1808.s1.e3", "normalized": [] }, { "id": "DS.d1808.s1.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d1808.s1.e0", "arg2_id": "DS.d1808.s1.e2", "normalized": [] } ]
DS.d1809
18932024
[ { "id": "DS.d1809.s0", "type": "", "text": [ "An efficient electrocatalytic biosensor for sulfite detection was developed by co-immobilizing sulfite oxidase and cytochrome c with polyaniline sulfonic acid in a layer-by-layer assembly." ], "offsets": [ [ 0, 188 ] ] } ]
[ { "id": "DS.d1809.s0.e0", "type": "protein", "text": [ "sulfite oxidase" ], "offsets": [ [ 95, 110 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07850" }, { "db_name": "UniProt", "db_id": "Q9S850" } ] }, { "id": "DS.d1809.s0.e1", "type": "protein", "text": [ "cytochrome c" ], "offsets": [ [ 115, 127 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O07091" }, { "db_name": "UniProt", "db_id": "O13393" }, { "db_name": "UniProt", "db_id": "O22642" }, { "db_name": "UniProt", "db_id": "O93863" }, { "db_name": "UniProt", "db_id": "P00002" }, { "db_name": "UniProt", "db_id": "P00003" }, { "db_name": "UniProt", "db_id": "P00004" }, { "db_name": "UniProt", "db_id": "P00007" }, { "db_name": "UniProt", "db_id": "P00008" }, { "db_name": "UniProt", "db_id": "P00011" }, { "db_name": "UniProt", "db_id": "P00012" }, { "db_name": "UniProt", "db_id": "P00013" }, { "db_name": "UniProt", "db_id": "P00014" }, { "db_name": "UniProt", "db_id": "P00017" }, { "db_name": "UniProt", "db_id": "P00018" }, { "db_name": "UniProt", "db_id": "P00019" }, { "db_name": "UniProt", "db_id": "P00020" }, { "db_name": "UniProt", "db_id": "P00021" }, { "db_name": "UniProt", "db_id": "P00022" }, { "db_name": "UniProt", "db_id": "P00024" }, { "db_name": "UniProt", "db_id": "P00025" }, { "db_name": "UniProt", "db_id": "P00027" }, { "db_name": "UniProt", "db_id": "P00028" }, { "db_name": "UniProt", "db_id": "P00029" }, { "db_name": "UniProt", "db_id": "P00030" }, { "db_name": "UniProt", "db_id": "P00031" }, { "db_name": "UniProt", "db_id": "P00032" }, { "db_name": "UniProt", "db_id": "P00035" }, { "db_name": "UniProt", "db_id": "P00036" }, { "db_name": "UniProt", "db_id": "P00037" }, { "db_name": "UniProt", "db_id": "P00038" }, { "db_name": "UniProt", "db_id": "P00039" }, { "db_name": "UniProt", "db_id": "P00040" }, { "db_name": "UniProt", "db_id": "P00041" }, { "db_name": "UniProt", "db_id": "P00042" }, { "db_name": "UniProt", "db_id": "P00043" }, { "db_name": "UniProt", "db_id": "P00046" 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"db_name": "UniProt", "db_id": "P00070" }, { "db_name": "UniProt", "db_id": "P00071" }, { "db_name": "UniProt", "db_id": "P00072" }, { "db_name": "UniProt", "db_id": "P00073" }, { "db_name": "UniProt", "db_id": "P00074" }, { "db_name": "UniProt", "db_id": "P00075" }, { "db_name": "UniProt", "db_id": "P00076" }, { "db_name": "UniProt", "db_id": "P00077" }, { "db_name": "UniProt", "db_id": "P00078" }, { "db_name": "UniProt", "db_id": "P00079" }, { "db_name": "UniProt", "db_id": "P12831" }, { "db_name": "UniProt", "db_id": "P15451" }, { "db_name": "UniProt", "db_id": "P18822" }, { "db_name": "UniProt", "db_id": "P19681" }, { "db_name": "UniProt", "db_id": "P19974" }, { "db_name": "UniProt", "db_id": "P21665" }, { "db_name": "UniProt", "db_id": "P22342" }, { "db_name": "UniProt", "db_id": "P25400" }, { "db_name": "UniProt", "db_id": "P29380" }, { "db_name": "UniProt", "db_id": "P32556" }, { "db_name": "UniProt", "db_id": "P38091" }, { "db_name": "UniProt", "db_id": "P53698" }, { "db_name": "UniProt", "db_id": "P56205" }, { "db_name": "UniProt", "db_id": "P59218" }, { "db_name": "UniProt", "db_id": "P62772" }, { "db_name": "UniProt", "db_id": "P62773" }, { "db_name": "UniProt", "db_id": "P62894" }, { "db_name": "UniProt", "db_id": "P62895" }, { "db_name": "UniProt", "db_id": "P62896" }, { "db_name": "UniProt", "db_id": "P67881" }, { "db_name": "UniProt", "db_id": "P67882" }, { "db_name": "UniProt", "db_id": "P68096" }, { "db_name": "UniProt", "db_id": "P68097" }, { "db_name": "UniProt", "db_id": "P68098" }, { "db_name": "UniProt", "db_id": "P68099" }, { "db_name": "UniProt", "db_id": "P68100" }, { "db_name": "UniProt", "db_id": "P68517" }, { "db_name": "UniProt", "db_id": "P68518" }, { "db_name": "UniProt", "db_id": "P68519" }, { "db_name": "UniProt", "db_id": "P81280" }, { "db_name": "UniProt", "db_id": "P81459" }, { "db_name": "UniProt", "db_id": "P99998" }, { "db_name": "UniProt", "db_id": "P99999" }, { "db_name": "UniProt", "db_id": "Q41346" }, { "db_name": "UniProt", "db_id": "Q4HVX7" }, { "db_name": "UniProt", "db_id": "Q52V08" }, { "db_name": "UniProt", "db_id": "Q52V09" }, { "db_name": "UniProt", "db_id": "Q52V10" }, { "db_name": "UniProt", "db_id": "Q5RFH4" }, { "db_name": "UniProt", "db_id": "Q640U4" }, { "db_name": "UniProt", "db_id": "Q6C9Q0" }, { "db_name": "UniProt", "db_id": "Q6IQM2" }, { "db_name": "UniProt", "db_id": "Q6Q4H8" }, { "db_name": "UniProt", "db_id": "Q6QLW4" }, { "db_name": "UniProt", "db_id": "Q6WUX8" }, { "db_name": "UniProt", "db_id": "Q753F4" }, { "db_name": "UniProt", "db_id": "Q7YR71" }, { "db_name": "UniProt", "db_id": "Q96VP3" } ] }, { "id": "DS.d1809.s0.e2", "type": "compound", "text": [ "sulfonic acid" ], "offsets": [ [ 145, 158 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104748" } ] } ]
[]
[]
[]
DS.d1810
18932046
[ { "id": "DS.d1810.s0", "type": "", "text": [ "After 10 days of treatment, otomicroscopic evaluation of tympanic membranes and measurement of anti-inflammatory mediators such as superoxide dismutase, nitrite/nitrate, glutathione peroxidase and malondialdehyde were performed." ], "offsets": [ [ 0, 228 ] ] }, { "id": "DS.d1810.s1", "type": "", "text": [ "The levels of malondialdehyde and superoxide dismutase were lower in ginkgo groups but not significantly." ], "offsets": [ [ 229, 334 ] ] } ]
[ { "id": "DS.d1810.s0.e0", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 131, 151 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d1810.s0.e1", "type": "protein", "text": [ "glutathione peroxidase" ], "offsets": [ [ 170, 192 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] }, { "id": "DS.d1810.s0.e2", "type": "compound", "text": [ "malondialdehyde" ], "offsets": [ [ 197, 212 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] }, { "id": "DS.d1810.s1.e0", "type": "compound", "text": [ "malondialdehyde" ], "offsets": [ [ 243, 258 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10964" } ] }, { "id": "DS.d1810.s1.e1", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 263, 283 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] } ]
[]
[]
[]
DS.d1811
18932201
[ { "id": "DS.d1811.s0", "type": "", "text": [ "These results indicate that cloned embryos have aberrant DNA methylation in the CpG sites of the PE region of Oct-4, and this may contribute directly to abnormal expression of this gene in cloned embryos." ], "offsets": [ [ 0, 204 ] ] } ]
[ { "id": "DS.d1811.s0.e0", "type": "compound", "text": [ "CpG" ], "offsets": [ [ 80, 83 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6804" } ] }, { "id": "DS.d1811.s0.e1", "type": "protein", "text": [ "Oct-4" ], "offsets": [ [ 110, 115 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O97552" }, { "db_name": "UniProt", "db_id": "P20263" }, { "db_name": "UniProt", "db_id": "Q01860" }, { "db_name": "UniProt", "db_id": "Q9TSV5" } ] } ]
[]
[]
[ { "id": "DS.d1811.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1811.s0.e0", "arg2_id": "DS.d1811.s0.e1", "normalized": [] } ]
DS.d1812
18932209
[ { "id": "DS.d1812.s0", "type": "", "text": [ "Xenopus follicle-enclosed oocytes are endowed with purinergic receptors located in the follicular cell membrane ; their stimulation by ATP elicits an electrical response that includes generation of a fast inward current (F(Cl)) carried by Cl(-)." ], "offsets": [ [ 0, 245 ] ] } ]
[ { "id": "DS.d1812.s0.e0", "type": "protein", "text": [ "purinergic receptors" ], "offsets": [ [ 51, 71 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15547" }, { "db_name": "UniProt", "db_id": "O54803" }, { "db_name": "UniProt", "db_id": "O70397" }, { "db_name": "UniProt", "db_id": "P34996" }, { "db_name": "UniProt", "db_id": "P35383" }, { "db_name": "UniProt", "db_id": "P41231" }, { "db_name": "UniProt", "db_id": "P41232" }, { "db_name": "UniProt", "db_id": "P47824" }, { "db_name": "UniProt", "db_id": "P47900" }, { "db_name": "UniProt", "db_id": "P48042" }, { "db_name": "UniProt", "db_id": "P49650" }, { "db_name": "UniProt", "db_id": "P49651" }, { "db_name": "UniProt", "db_id": "P49652" }, { "db_name": "UniProt", "db_id": "P49653" }, { "db_name": "UniProt", "db_id": "P49654" }, { "db_name": "UniProt", "db_id": "P51575" }, { "db_name": "UniProt", "db_id": "P51576" }, { "db_name": "UniProt", "db_id": "P51577" }, { "db_name": "UniProt", "db_id": "P51578" }, { "db_name": "UniProt", "db_id": "P51579" }, { "db_name": "UniProt", "db_id": "P56373" }, { "db_name": "UniProt", "db_id": "P59902" }, { "db_name": "UniProt", "db_id": "Q64663" }, { "db_name": "UniProt", "db_id": "Q93086" }, { "db_name": "UniProt", "db_id": "Q99571" }, { "db_name": "UniProt", "db_id": "Q99572" }, { "db_name": "UniProt", "db_id": "Q9UBL9" }, { "db_name": "UniProt", "db_id": "Q9Z1M0" } ] }, { "id": "DS.d1812.s0.e1", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 135, 138 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] } ]
[]
[]
[ { "id": "DS.d1812.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1812.s0.e1", "arg2_id": "DS.d1812.s0.e0", "normalized": [] } ]
DS.d1813
18932227
[ { "id": "DS.d1813.s0", "type": "", "text": [ "Moreover, the dopaminergic and glutamatergic regulation of Homer1 gene activation by cocaine was investigated." ], "offsets": [ [ 0, 110 ] ] }, { "id": "DS.d1813.s1", "type": "", "text": [ "The acute cocaine-mediated activation of Homer1 gene was regulated by D1 but not D2 dopamine receptors." ], "offsets": [ [ 111, 214 ] ] }, { "id": "DS.d1813.s2", "type": "", "text": [ "Activation of Homer1 gene may contribute to the cocaine-mediated synaptic and behavioral plasticity." ], "offsets": [ [ 215, 315 ] ] } ]
[ { "id": "DS.d1813.s0.e0", "type": "protein", "text": [ "Homer1" ], "offsets": [ [ 59, 65 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9Z214" }, { "db_name": "UniProt", "db_id": "Q9Z2Y3" } ] }, { "id": "DS.d1813.s0.e1", "type": "compound", "text": [ "cocaine" ], "offsets": [ [ 85, 92 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2826" }, { "db_name": "PubChem", "db_id": "5760" }, { "db_name": "PubChem", "db_id": "439497" }, { "db_name": "PubChem", "db_id": "446220" }, { "db_name": "PubChem", "db_id": "644017" }, { "db_name": "PubChem", "db_id": "54613779" } ] }, { "id": "DS.d1813.s1.e0", "type": "compound", "text": [ "cocaine" ], "offsets": [ [ 121, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2826" }, { "db_name": "PubChem", "db_id": "5760" }, { "db_name": "PubChem", "db_id": "439497" }, { "db_name": "PubChem", "db_id": "446220" }, { "db_name": "PubChem", "db_id": "644017" }, { "db_name": "PubChem", "db_id": "54613779" } ] }, { "id": "DS.d1813.s1.e1", "type": "protein", "text": [ "Homer1" ], "offsets": [ [ 152, 158 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9Z214" }, { "db_name": "UniProt", "db_id": "Q9Z2Y3" } ] }, { "id": "DS.d1813.s2.e0", "type": "protein", "text": [ "Homer1" ], "offsets": [ [ 229, 235 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9Z214" }, { "db_name": "UniProt", "db_id": "Q9Z2Y3" } ] }, { "id": "DS.d1813.s2.e1", "type": "compound", "text": [ "cocaine" ], "offsets": [ [ 263, 270 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2826" }, { "db_name": "PubChem", "db_id": "5760" }, { "db_name": "PubChem", "db_id": "439497" }, { "db_name": "PubChem", "db_id": "446220" }, { "db_name": "PubChem", "db_id": "644017" }, { "db_name": "PubChem", "db_id": "54613779" } ] } ]
[]
[]
[ { "id": "DS.d1813.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1813.s0.e1", "arg2_id": "DS.d1813.s0.e0", "normalized": [] }, { "id": "DS.d1813.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1813.s1.e0", "arg2_id": "DS.d1813.s1.e1", "normalized": [] }, { "id": "DS.d1813.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1813.s2.e1", "arg2_id": "DS.d1813.s2.e0", "normalized": [] } ]
DS.d1815
18935970
[ { "id": "DS.d1815.s0", "type": "", "text": [ "Eukaryotes plus their archaebacterial sisters form the clade neomura, which evolved from a radically modified derivative of an actinobacterial posibacterium that had replaced the ancestral eubacterial murein peptidoglycan by N-linked glycoproteins, radically modified its DNA-handling enzymes, and evolved cotranslational protein secretion, but not the isoprenoid-ether lipids of archaebacteria." ], "offsets": [ [ 0, 395 ] ] } ]
[ { "id": "DS.d1815.s0.e0", "type": "compound", "text": [ "peptidoglycan" ], "offsets": [ [ 208, 221 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9816401" } ] }, { "id": "DS.d1815.s0.e1", "type": "protein", "text": [ "glycoproteins" ], "offsets": [ [ 234, 247 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] }, { "id": "DS.d1815.s0.e2", "type": "compound", "text": [ "ether" ], "offsets": [ [ 364, 369 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3283" }, { "db_name": "PubChem", "db_id": "5382654" } ] } ]
[]
[]
[ { "id": "DS.d1815.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1815.s0.e0", "arg2_id": "DS.d1815.s0.e1", "normalized": [] } ]
DS.d1816
18935973
[ { "id": "DS.d1816.s0", "type": "", "text": [ "Necrostatin-1, a new inhibitor of non-apoptotic death, rescued cells from death by RIPs, although the effect was also partial and temporary." ], "offsets": [ [ 0, 140 ] ] } ]
[ { "id": "DS.d1816.s0.e0", "type": "compound", "text": [ "Necrostatin-1" ], "offsets": [ [ 0, 13 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2828334" } ] }, { "id": "DS.d1816.s0.e1", "type": "protein", "text": [ "RIPs" ], "offsets": [ [ 83, 87 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24817" }, { "db_name": "UniProt", "db_id": "P52594" }, { "db_name": "UniProt", "db_id": "P56626" }, { "db_name": "UniProt", "db_id": "Q13546" }, { "db_name": "UniProt", "db_id": "Q2TA45" }, { "db_name": "UniProt", "db_id": "Q86UA6" } ] } ]
[]
[]
[ { "id": "DS.d1816.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1816.s0.e0", "arg2_id": "DS.d1816.s0.e1", "normalized": [] } ]
DS.d1817
18935985
[ { "id": "DS.d1817.s0", "type": "", "text": [ "Here we show the first direct quantitative evidence for PAP binding to the cap analog m(7)GTP." ], "offsets": [ [ 0, 94 ] ] }, { "id": "DS.d1817.s1", "type": "", "text": [ "van't Hoff analysis of m(7)GTP-PAP equilibrium reveals a binding reaction that is enthalpy driven and entropy favored with TDeltaS degrees contributing 15% to the overall value of DeltaG degrees." ], "offsets": [ [ 95, 290 ] ] }, { "id": "DS.d1817.s2", "type": "", "text": [ "eIFiso4G was shown to enhance the interaction of PAP with m(7)GTP cap analog by 2.4-fold." ], "offsets": [ [ 291, 380 ] ] } ]
[ { "id": "DS.d1817.s0.e0", "type": "protein", "text": [ "PAP" ], "offsets": [ [ 56, 59 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32449" }, { "db_name": "UniProt", "db_id": "O43150" }, { "db_name": "UniProt", "db_id": "O74326" }, { "db_name": "UniProt", "db_id": "O74518" }, { "db_name": "UniProt", "db_id": "O83041" }, { "db_name": "UniProt", "db_id": "O96690" }, { "db_name": "UniProt", "db_id": "P09274" }, { "db_name": "UniProt", "db_id": "P0ABF1" }, { "db_name": "UniProt", "db_id": "P0ABF2" }, { "db_name": "UniProt", "db_id": "P0ABF3" }, { "db_name": "UniProt", "db_id": "P10226" }, { "db_name": "UniProt", "db_id": "P16790" }, { "db_name": "UniProt", "db_id": "P25500" }, { "db_name": "UniProt", "db_id": "P27417" }, { "db_name": "UniProt", "db_id": "P28958" }, { "db_name": "UniProt", "db_id": "P29468" }, { "db_name": "UniProt", "db_id": "P36322" }, { "db_name": "UniProt", "db_id": "P36702" }, { "db_name": "UniProt", "db_id": "P42786" }, { "db_name": "UniProt", "db_id": "P44439" }, { "db_name": "UniProt", "db_id": "P46541" }, { "db_name": "UniProt", "db_id": "P46542" }, { "db_name": "UniProt", "db_id": "P46544" }, { "db_name": "UniProt", "db_id": "P46547" }, { "db_name": "UniProt", "db_id": "P47266" }, { "db_name": "UniProt", "db_id": "P51003" }, { "db_name": "UniProt", "db_id": "P51004" }, { "db_name": "UniProt", "db_id": "P51005" }, { "db_name": "UniProt", "db_id": "P51006" }, { "db_name": "UniProt", "db_id": "P52278" }, { "db_name": "UniProt", "db_id": "P52279" }, { "db_name": "UniProt", "db_id": "P52439" }, { "db_name": "UniProt", "db_id": "P52440" }, { "db_name": "UniProt", "db_id": "P75092" }, { "db_name": "UniProt", "db_id": "P80366" }, { "db_name": "UniProt", "db_id": "P84399" }, { "db_name": "UniProt", "db_id": "P93732" }, { "db_name": "UniProt", "db_id": "P96084" }, { "db_name": "UniProt", "db_id": "Q06141" }, { "db_name": "UniProt", "db_id": "Q09131" }, { "db_name": "UniProt", "db_id": "Q10295" }, { "db_name": "UniProt", "db_id": "Q13442" }, { "db_name": "UniProt", "db_id": "Q38924" }, { "db_name": "UniProt", "db_id": "Q3UHX2" }, { "db_name": "UniProt", "db_id": "Q51D88" }, { "db_name": "UniProt", "db_id": "Q61183" }, { "db_name": "UniProt", "db_id": "Q62785" }, { "db_name": "UniProt", "db_id": "Q7SIG6" }, { "db_name": "UniProt", "db_id": "Q87DF8" }, { "db_name": "UniProt", "db_id": "Q8Z9C3" }, { "db_name": "UniProt", "db_id": "Q8ZRQ8" }, { "db_name": "UniProt", "db_id": "Q97A76" }, { "db_name": "UniProt", "db_id": "Q97UA2" }, { "db_name": "UniProt", "db_id": "Q9D0D3" }, { "db_name": "UniProt", "db_id": "Q9JUV1" }, { "db_name": "UniProt", "db_id": "Q9JZR6" }, { "db_name": "UniProt", "db_id": "Q9NVV4" }, { "db_name": "UniProt", "db_id": "Q9PD69" }, { "db_name": "UniProt", "db_id": "Q9S2L4" }, { "db_name": "UniProt", "db_id": "Q9UT49" }, { "db_name": "UniProt", "db_id": "Q9UTN3" }, { "db_name": "UniProt", "db_id": "Q9ZWQ8" } ] }, { "id": "DS.d1817.s0.e1", "type": "compound", "text": [ "m(7)GTP" ], "offsets": [ [ 86, 93 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444378" } ] }, { "id": "DS.d1817.s1.e0", "type": "compound", "text": [ "m(7)GTP" ], "offsets": [ [ 118, 125 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444378" } ] }, { "id": "DS.d1817.s1.e1", "type": "protein", "text": [ "PAP" ], "offsets": [ [ 126, 129 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32449" }, { "db_name": "UniProt", "db_id": "O43150" }, { "db_name": "UniProt", "db_id": "O74326" }, { "db_name": "UniProt", "db_id": "O74518" }, { "db_name": "UniProt", "db_id": "O83041" }, { "db_name": "UniProt", "db_id": "O96690" }, { "db_name": "UniProt", "db_id": "P09274" }, { "db_name": "UniProt", "db_id": "P0ABF1" }, { "db_name": "UniProt", "db_id": "P0ABF2" }, { "db_name": "UniProt", "db_id": "P0ABF3" }, { "db_name": "UniProt", "db_id": "P10226" }, { "db_name": "UniProt", "db_id": "P16790" }, { "db_name": "UniProt", "db_id": "P25500" }, { "db_name": "UniProt", "db_id": "P27417" }, { "db_name": "UniProt", "db_id": "P28958" }, { "db_name": "UniProt", "db_id": "P29468" }, { "db_name": "UniProt", "db_id": "P36322" }, { "db_name": "UniProt", "db_id": "P36702" }, { "db_name": "UniProt", "db_id": "P42786" }, { "db_name": "UniProt", "db_id": "P44439" }, { "db_name": "UniProt", "db_id": "P46541" }, { "db_name": "UniProt", "db_id": "P46542" }, { "db_name": "UniProt", "db_id": "P46544" }, { "db_name": "UniProt", "db_id": "P46547" }, { "db_name": "UniProt", "db_id": "P47266" }, { "db_name": "UniProt", "db_id": "P51003" }, { "db_name": "UniProt", "db_id": "P51004" }, { "db_name": "UniProt", "db_id": "P51005" }, { "db_name": "UniProt", "db_id": "P51006" }, { "db_name": "UniProt", "db_id": "P52278" }, { "db_name": "UniProt", "db_id": "P52279" }, { "db_name": "UniProt", "db_id": "P52439" }, { "db_name": "UniProt", "db_id": "P52440" }, { "db_name": "UniProt", "db_id": "P75092" }, { "db_name": "UniProt", "db_id": "P80366" }, { "db_name": "UniProt", "db_id": "P84399" }, { "db_name": "UniProt", "db_id": 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}, { "db_name": "UniProt", "db_id": "Q9UT49" }, { "db_name": "UniProt", "db_id": "Q9UTN3" }, { "db_name": "UniProt", "db_id": "Q9ZWQ8" } ] }, { "id": "DS.d1817.s2.e0", "type": "protein", "text": [ "PAP" ], "offsets": [ [ 340, 343 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32449" }, { "db_name": "UniProt", "db_id": "O43150" }, { "db_name": "UniProt", "db_id": "O74326" }, { "db_name": "UniProt", "db_id": "O74518" }, { "db_name": "UniProt", "db_id": "O83041" }, { "db_name": "UniProt", "db_id": "O96690" }, { "db_name": "UniProt", "db_id": "P09274" }, { "db_name": "UniProt", "db_id": "P0ABF1" }, { "db_name": "UniProt", "db_id": "P0ABF2" }, { "db_name": "UniProt", "db_id": "P0ABF3" }, { "db_name": "UniProt", "db_id": "P10226" }, { "db_name": "UniProt", "db_id": "P16790" }, { "db_name": "UniProt", "db_id": "P25500" }, { "db_name": "UniProt", "db_id": "P27417" }, { "db_name": "UniProt", "db_id": "P28958" }, { "db_name": "UniProt", "db_id": "P29468" }, { "db_name": "UniProt", 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}, { "db_name": "UniProt", "db_id": "Q9ZWQ8" } ] }, { "id": "DS.d1817.s2.e1", "type": "compound", "text": [ "m(7)GTP" ], "offsets": [ [ 349, 356 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444378" } ] } ]
[]
[]
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DS.d1819
18936084
[ { "id": "DS.d1819.s0", "type": "", "text": [ "In granulosa-lutein cells, STAR transcript abundance was not affected by BMP6, whereas forskolin-induced expression of CYP11A1, HSD3B1, CYP19A1 and oxytocin transcripts was reduced." ], "offsets": [ [ 0, 181 ] ] }, { "id": "DS.d1819.s1", "type": "", "text": [ "In both cell types, follistatin attenuated the suppressive effect of activin A and BMP6 on forskolin-induced P4 secretion but had no effect alone." ], "offsets": [ [ 182, 328 ] ] } ]
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[]
[]
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DS.d1820
18936109
[ { "id": "DS.d1820.s0", "type": "", "text": [ "1-Aminobenzotriazole (1-ABT) is generally considered to be a nonselective mechanism-based inactivator of both human and non-human cytochrome P450 (P450) enzymes." ], "offsets": [ [ 0, 161 ] ] } ]
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[]
[]
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DS.d1821
18936140
[ { "id": "DS.d1821.s0", "type": "", "text": [ "7-Ketocholesterol is present in lipid deposits in the primate retina: potential implication in the induction of VEGF and CNV formation." ], "offsets": [ [ 0, 135 ] ] } ]
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[]
[]
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DS.d1822
18936181
[ { "id": "DS.d1822.s0", "type": "", "text": [ "ETEC infection also caused a drastic inhibition of host esterase activity, as measured by calcein fluorescence." ], "offsets": [ [ 0, 111 ] ] } ]
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[]
[]
[]
DS.d1823
18936191
[ { "id": "DS.d1823.s0", "type": "", "text": [ "HCV-796 is a nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) polymerase, and boceprevir is an inhibitor of the NS3 serine protease." ], "offsets": [ [ 0, 170 ] ] }, { "id": "DS.d1823.s2", "type": "", "text": [ "Mutations known to confer resistance to HCV-796 (NS5B C316Y) and boceprevir (NS3 V170A) were present in the combination-resistant replicons." ], "offsets": [ [ 171, 311 ] ] } ]
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[]
[]
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DS.d1825
18936772
[ { "id": "DS.d1825.s0", "type": "", "text": [ "Increased apoptosis of a human salivary gland (HSG) cell line occurred only in the presence of lipopolysaccharide (LPS-) and interferon (IFN)-gamma-stimulated human monocytic THP-1 cells, which was reversed when caspase-1 in THP-1 cells was targeted by siRNA." ], "offsets": [ [ 0, 259 ] ] } ]
[ { "id": "DS.d1825.s0.e0", "type": "compound", "text": [ "lipopolysaccharide" ], "offsets": [ [ 95, 113 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "11970143" } ] }, { "id": "DS.d1825.s0.e1", "type": "protein", "text": [ "IFN" ], "offsets": [ [ 137, 140 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P28172" }, { "db_name": "UniProt", "db_id": "P51526" } ] } ]
[]
[]
[]
DS.d1826
18936912
[ { "id": "DS.d1826.s0", "type": "", "text": [ "A role for atorvastatin and insulin combination in protecting from liver injury in a model of type 2 diabetes with hyperlipidemia." ], "offsets": [ [ 0, 130 ] ] }, { "id": "DS.d1826.s1", "type": "", "text": [ "Genetic type 2 diabetic Goto-Kakizaki rats were fed with a high-fat diet to test hepatic effects of type 2 diabetes with hyperlipidemia and the effect of atorvastatin and insulin, individually and in combination, in systemic and hepatic inflammatory and oxidative stress markers." ], "offsets": [ [ 131, 410 ] ] }, { "id": "DS.d1826.s2", "type": "", "text": [ "Combination of insulin and atorvastatin further improved glycemic and lipid profiles and decreased circulating C-reactive protein levels and liver inflammatory and oxidative stress markers." ], "offsets": [ [ 411, 600 ] ] }, { "id": "DS.d1826.s3", "type": "", "text": [ "Insulin and atorvastatin combination leads to better glycaemic and lipid profiles and to better protection against liver inflammation and oxidative stress, giving a superior level of liver protection in type 2 diabetic with hyperlipidemia." ], "offsets": [ [ 601, 840 ] ] } ]
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"UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1826.s2.e0", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 426, 433 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1826.s2.e1", "type": "compound", "text": [ "atorvastatin" ], "offsets": [ [ 438, 450 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "60823" } ] }, { "id": "DS.d1826.s3.e0", "type": "protein", "text": [ "Insulin" ], "offsets": [ [ 601, 608 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1826.s3.e1", "type": "compound", "text": [ "atorvastatin" ], "offsets": [ [ 613, 625 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "60823" } ] } ]
[]
[]
[]
DS.d1827
18936931
[ { "id": "DS.d1827.s0", "type": "", "text": [ "Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem." ], "offsets": [ [ 0, 178 ] ] }, { "id": "DS.d1827.s1", "type": "", "text": [ "The aim of this study was to assess the influence of the cytochrome (CYP450)3A5 and multidrug resistance (MDR1) gene polymorphisms on cyclosporine A (CsA) trough concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem." ], "offsets": [ [ 179, 452 ] ] } ]
[ { "id": "DS.d1827.s0.e0", "type": "protein", "text": [ "CYP3A5" ], "offsets": [ [ 35, 41 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20815" } ] }, { "id": "DS.d1827.s0.e1", "type": "protein", "text": [ "MDR1" ], "offsets": [ [ 46, 50 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08183" }, { "db_name": "UniProt", "db_id": "P13568" }, { "db_name": "UniProt", "db_id": "P16875" }, { "db_name": "UniProt", "db_id": "P28873" }, { "db_name": "UniProt", "db_id": "P53258" }, { "db_name": "UniProt", "db_id": "Q06034" }, { "db_name": "UniProt", "db_id": "Q9LJX0" }, { "db_name": "UniProt", "db_id": "Q9ZR72" } ] }, { "id": "DS.d1827.s0.e2", "type": "compound", "text": [ "cyclosporine" ], "offsets": [ [ 54, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280754" }, { "db_name": "PubChem", "db_id": "5284373" }, { "db_name": "PubChem", "db_id": "5497195" }, { "db_name": "PubChem", "db_id": "6435893" }, { "db_name": "PubChem", "db_id": "24883466" }, { "db_name": "PubChem", "db_id": "25246316" } ] }, { "id": "DS.d1827.s0.e3", "type": "compound", "text": [ "diltiazem" ], "offsets": [ [ 168, 177 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "39186" } ] }, { "id": "DS.d1827.s1.e0", "type": "protein", "text": [ "MDR1" ], "offsets": [ [ 285, 289 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08183" }, { "db_name": "UniProt", "db_id": "P13568" }, { "db_name": "UniProt", "db_id": "P16875" }, { "db_name": "UniProt", "db_id": "P28873" }, { "db_name": "UniProt", "db_id": "P53258" }, { "db_name": "UniProt", "db_id": "Q06034" }, { "db_name": "UniProt", "db_id": "Q9LJX0" }, { "db_name": "UniProt", "db_id": "Q9ZR72" } ] }, { "id": "DS.d1827.s1.e1", "type": "compound", "text": [ "cyclosporine A" ], "offsets": [ [ 313, 327 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2909" }, { "db_name": "PubChem", "db_id": "5280754" }, { "db_name": "PubChem", "db_id": "5284373" }, { "db_name": "PubChem", "db_id": "5497195" }, { "db_name": "PubChem", "db_id": "6435893" }, { "db_name": "PubChem", "db_id": "49867938" } ] }, { "id": "DS.d1827.s1.e2", "type": "compound", "text": [ "diltiazem" ], "offsets": [ [ 442, 451 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "39186" } ] } ]
[]
[]
[]
DS.d1828
18936963
[ { "id": "DS.d1828.s0", "type": "", "text": [ "The-417- and-593 bp promoter regions were sufficient for GUS gene activation by ethylene and methyl jasmonate treatments, respectively." ], "offsets": [ [ 0, 135 ] ] } ]
[ { "id": "DS.d1828.s0.e0", "type": "protein", "text": [ "GUS" ], "offsets": [ [ 57, 60 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05804" } ] }, { "id": "DS.d1828.s0.e1", "type": "compound", "text": [ "ethylene" ], "offsets": [ [ 80, 88 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6325" }, { "db_name": "PubChem", "db_id": "21159546" } ] }, { "id": "DS.d1828.s0.e2", "type": "compound", "text": [ "methyl jasmonate" ], "offsets": [ [ 93, 109 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "62388" }, { "db_name": "PubChem", "db_id": "5281929" }, { "db_name": "PubChem", "db_id": "5319693" }, { "db_name": "PubChem", "db_id": "5367719" }, { "db_name": "PubChem", "db_id": "6432008" } ] } ]
[]
[]
[ { "id": "DS.d1828.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1828.s0.e2", "arg2_id": "DS.d1828.s0.e0", "normalized": [] }, { "id": "DS.d1828.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1828.s0.e1", "arg2_id": "DS.d1828.s0.e0", "normalized": [] } ]
DS.d1829
18936983
[ { "id": "DS.d1829.s0", "type": "", "text": [ "Reversible two-step unfolding of heme-human serum albumin : a (1)H-NMR relaxometric and circular dichroism study." ], "offsets": [ [ 0, 113 ] ] }, { "id": "DS.d1829.s1", "type": "", "text": [ "Human serum albumin (HSA) participates in heme scavenging, the bound heme turning out to be a reactivity center and a powerful spectroscopic probe." ], "offsets": [ [ 114, 261 ] ] }, { "id": "DS.d1829.s2", "type": "", "text": [ "Here, the reversible unfolding of heme-HSA has been investigated by (1)H-NMR relaxometry, circular dichroism, and absorption spectroscopy." ], "offsets": [ [ 262, 400 ] ] } ]
[ { "id": "DS.d1829.s0.e0", "type": "compound", "text": [ "heme" ], "offsets": [ [ 33, 37 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4971" } ] }, { "id": "DS.d1829.s0.e1", "type": "protein", "text": [ "serum albumin" ], "offsets": [ [ 44, 57 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P83517" } ] }, { "id": "DS.d1829.s1.e0", "type": "protein", "text": [ "serum albumin" ], "offsets": [ [ 120, 133 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P83517" } ] }, { "id": "DS.d1829.s1.e1", "type": "protein", "text": [ "HSA" ], "offsets": [ [ 135, 138 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24807" }, { "db_name": "UniProt", "db_id": "Q07490" } ] }, { "id": "DS.d1829.s1.e2", "type": "compound", "text": [ "heme" ], "offsets": [ [ 156, 160 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4971" } ] }, { "id": "DS.d1829.s1.e3", "type": "compound", "text": [ "heme" ], "offsets": [ [ 183, 187 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4971" } ] }, { "id": "DS.d1829.s2.e0", "type": "compound", "text": [ "heme" ], "offsets": [ [ 296, 300 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4971" } ] }, { "id": "DS.d1829.s2.e1", "type": "protein", "text": [ "HSA" ], "offsets": [ [ 301, 304 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24807" }, { "db_name": "UniProt", "db_id": "Q07490" } ] } ]
[]
[]
[ { "id": "DS.d1829.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1829.s0.e0", "arg2_id": "DS.d1829.s0.e1", "normalized": [] }, { "id": "DS.d1829.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1829.s1.e2", "arg2_id": "DS.d1829.s1.e1", "normalized": [] }, { "id": "DS.d1829.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1829.s1.e2", "arg2_id": "DS.d1829.s1.e0", "normalized": [] }, { "id": "DS.d1829.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1829.s2.e0", "arg2_id": "DS.d1829.s2.e1", "normalized": [] } ]
DS.d1830
18936994
[ { "id": "DS.d1830.s0", "type": "", "text": [ "The purified enzymes were a monomer with an apparent molecular mass of 32 kDa (Chi32) and 46 kDa (Chi46), respectively, and showed chitinase activity bands with 0.01% glycol chitin as a substrate after SDS-PAGE." ], "offsets": [ [ 0, 211 ] ] } ]
[ { "id": "DS.d1830.s0.e0", "type": "protein", "text": [ "chitinase" ], "offsets": [ [ 131, 140 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13656" }, { "db_name": "UniProt", "db_id": "P14529" }, { "db_name": "UniProt", "db_id": "P23472" }, { "db_name": "UniProt", "db_id": "P23473" }, { "db_name": "UniProt", "db_id": "P81241" }, { "db_name": "UniProt", "db_id": "P84754" } ] }, { "id": "DS.d1830.s0.e1", "type": "compound", "text": [ "glycol" ], "offsets": [ [ 167, 173 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "174" } ] } ]
[]
[]
[]
DS.d1833
18937073
[ { "id": "DS.d1833.s0", "type": "", "text": [ "Possible relation of hemin-induced HO-1 expression to the upregulation of VEGF and BDNF mRNA levels in rat C6 glioma cells." ], "offsets": [ [ 0, 123 ] ] }, { "id": "DS.d1833.s1", "type": "", "text": [ "Based on this hypothetical idea, the direct effect of hemin on the expression of genes encoding heme oxygenase-1 (HO-1), vascular endothelial growth factor (VEGF), and brain-derived neurotrophic factor (BDNF) in glial cells was examined using rat C6 glioma cells as an in vitro model system." ], "offsets": [ [ 124, 415 ] ] } ]
[ { "id": "DS.d1833.s0.e0", "type": "compound", "text": [ "hemin" ], "offsets": [ [ 21, 26 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4971" } ] }, { "id": "DS.d1833.s0.e1", "type": "protein", "text": [ "HO-1" ], "offsets": [ [ 35, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06762" }, { "db_name": "UniProt", "db_id": "P09601" }, { "db_name": "UniProt", "db_id": "P14791" }, { "db_name": "UniProt", "db_id": "P14901" }, { "db_name": "UniProt", "db_id": "P32394" }, { "db_name": "UniProt", "db_id": "Q5E9F2" } ] }, { "id": "DS.d1833.s0.e2", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 74, 78 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d1833.s0.e3", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 83, 87 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d1833.s1.e0", "type": "compound", "text": [ "hemin" ], "offsets": [ [ 178, 183 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4971" } ] }, { "id": "DS.d1833.s1.e1", "type": "protein", "text": [ "heme oxygenase-1" ], "offsets": [ [ 220, 236 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06762" }, { "db_name": "UniProt", "db_id": "P09601" }, { "db_name": "UniProt", "db_id": "P14791" }, { "db_name": "UniProt", "db_id": "P14901" }, { "db_name": "UniProt", "db_id": "P32394" }, { "db_name": "UniProt", "db_id": "P72849" }, { "db_name": "UniProt", "db_id": "Q5E9F2" } ] }, { "id": "DS.d1833.s1.e2", "type": "protein", "text": [ "HO-1" ], "offsets": [ [ 238, 242 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06762" }, { "db_name": "UniProt", "db_id": "P09601" }, { "db_name": "UniProt", "db_id": "P14791" }, { "db_name": "UniProt", "db_id": "P14901" }, { "db_name": "UniProt", "db_id": "P32394" }, { "db_name": "UniProt", "db_id": "Q5E9F2" } ] }, { "id": "DS.d1833.s1.e3", "type": "protein", "text": [ "VEGF" ], "offsets": [ [ 281, 285 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P15691" }, { "db_name": "UniProt", "db_id": "P15692" }, { "db_name": "UniProt", "db_id": "P26617" }, { "db_name": "UniProt", "db_id": "P49151" }, { "db_name": "UniProt", "db_id": "P50412" }, { "db_name": "UniProt", "db_id": "P67964" }, { "db_name": "UniProt", "db_id": "P67965" }, { "db_name": "UniProt", "db_id": "Q99PS1" }, { "db_name": "UniProt", "db_id": "Q9GKR0" }, { "db_name": "UniProt", "db_id": "Q9MYV3" } ] }, { "id": "DS.d1833.s1.e4", "type": "protein", "text": [ "brain-derived neurotrophic factor" ], "offsets": [ [ 292, 325 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q06225" } ] }, { "id": "DS.d1833.s1.e5", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 327, 331 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] } ]
[]
[]
[ { "id": "DS.d1833.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1833.s0.e0", "arg2_id": "DS.d1833.s0.e1", "normalized": [] }, { "id": "DS.d1833.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1833.s0.e0", "arg2_id": "DS.d1833.s0.e2", "normalized": [] }, { "id": "DS.d1833.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1833.s0.e0", "arg2_id": "DS.d1833.s0.e3", "normalized": [] }, { "id": "DS.d1833.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1833.s1.e0", "arg2_id": "DS.d1833.s1.e1", "normalized": [] }, { "id": "DS.d1833.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1833.s1.e0", "arg2_id": "DS.d1833.s1.e2", "normalized": [] }, { "id": "DS.d1833.s1.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1833.s1.e0", "arg2_id": "DS.d1833.s1.e4", "normalized": [] }, { "id": "DS.d1833.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1833.s1.e0", "arg2_id": "DS.d1833.s1.e3", "normalized": [] }, { "id": "DS.d1833.s1.i4", "type": "compound-protein-interaction", "arg1_id": "DS.d1833.s1.e0", "arg2_id": "DS.d1833.s1.e5", "normalized": [] } ]
DS.d1834
18937079
[ { "id": "DS.d1834.s0", "type": "", "text": [ "Furthermore, we study the Akt activation after As(2)O(3) treatment and the HCC cells proliferation after combination of As(2)O(3) with PI3K inhibitor Wortmannin." ], "offsets": [ [ 0, 161 ] ] } ]
[ { "id": "DS.d1834.s0.e0", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 26, 29 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] }, { "id": "DS.d1834.s0.e1", "type": "compound", "text": [ "Wortmannin" ], "offsets": [ [ 150, 160 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "312145" } ] } ]
[]
[]
[]
DS.d1835
18937214
[ { "id": "DS.d1835.s0", "type": "", "text": [ "Carbofuran is a pesticide whose acute toxicity is due to inhibition of acetylcholinesterase." ], "offsets": [ [ 0, 92 ] ] } ]
[ { "id": "DS.d1835.s0.e0", "type": "compound", "text": [ "Carbofuran" ], "offsets": [ [ 0, 10 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2566" } ] }, { "id": "DS.d1835.s0.e1", "type": "protein", "text": [ "acetylcholinesterase" ], "offsets": [ [ 71, 91 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q867X2" }, { "db_name": "UniProt", "db_id": "Q867X3" }, { "db_name": "UniProt", "db_id": "Q86GC9" }, { "db_name": "UniProt", "db_id": "Q92081" } ] } ]
[]
[]
[ { "id": "DS.d1835.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1835.s0.e0", "arg2_id": "DS.d1835.s0.e1", "normalized": [] } ]
DS.d1836
18937289
[ { "id": "DS.d1836.s0", "type": "", "text": [ "The interaction of propafenone (PPF) enantiomers with human plasma, human serum albumin (HSA), alpha(1)-acid glycoprotein (AGP), as well as with plasma from rat, rabbit, and cow was investigated using indirect chiral high performance liquid chromatography (HPLC) and ultrafiltration techniques." ], "offsets": [ [ 0, 294 ] ] } ]
[ { "id": "DS.d1836.s0.e0", "type": "compound", "text": [ "propafenone" ], "offsets": [ [ 19, 30 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4932" } ] }, { "id": "DS.d1836.s0.e1", "type": "compound", "text": [ "PPF" ], "offsets": [ [ 32, 35 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "70387" } ] }, { "id": "DS.d1836.s0.e2", "type": "protein", "text": [ "serum albumin" ], "offsets": [ [ 74, 87 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P83517" } ] }, { "id": "DS.d1836.s0.e3", "type": "protein", "text": [ "HSA" ], "offsets": [ [ 89, 92 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24807" }, { "db_name": "UniProt", "db_id": "Q07490" } ] } ]
[]
[]
[]
DS.d1837
18937323
[ { "id": "DS.d1837.s0", "type": "", "text": [ "cAMP-Epac2-mediated activation of Rap1 in developing male germ cells: RA-RhoGAP as a possible direct down-stream effector." ], "offsets": [ [ 0, 122 ] ] }, { "id": "DS.d1837.s1", "type": "", "text": [ "Taken together, our results, obtained with endogenously expressed proteins, are consistent with a cAMP/Epac2/Rap1-mediated signaling that could exert its action, among others, through RA-RhoGAP to promote the progression of spermatogenesis." ], "offsets": [ [ 123, 363 ] ] } ]
[ { "id": "DS.d1837.s0.e0", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] }, { "id": "DS.d1837.s0.e1", "type": "protein", "text": [ "Epac2" ], "offsets": [ [ 5, 10 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9EQZ6" }, { "db_name": "UniProt", "db_id": "Q9Z1C7" } ] }, { "id": "DS.d1837.s0.e2", "type": "protein", "text": [ "Rap1" ], "offsets": [ [ 34, 38 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08645" }, { "db_name": "UniProt", "db_id": "P18613" }, { "db_name": "UniProt", "db_id": "Q91VL8" }, { "db_name": "UniProt", "db_id": "Q96TL7" } ] }, { "id": "DS.d1837.s1.e0", "type": "compound", "text": [ "cAMP" ], "offsets": [ [ 221, 225 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6076" } ] }, { "id": "DS.d1837.s1.e1", "type": "protein", "text": [ "Epac2" ], "offsets": [ [ 226, 231 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9EQZ6" }, { "db_name": "UniProt", "db_id": "Q9Z1C7" } ] }, { "id": "DS.d1837.s1.e2", "type": "protein", "text": [ "Rap1" ], "offsets": [ [ 232, 236 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08645" }, { "db_name": "UniProt", "db_id": "P18613" }, { "db_name": "UniProt", "db_id": "Q91VL8" }, { "db_name": "UniProt", "db_id": "Q96TL7" } ] } ]
[]
[]
[ { "id": "DS.d1837.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1837.s0.e0", "arg2_id": "DS.d1837.s0.e2", "normalized": [] }, { "id": "DS.d1837.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1837.s0.e0", "arg2_id": "DS.d1837.s0.e1", "normalized": [] }, { "id": "DS.d1837.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1837.s1.e0", "arg2_id": "DS.d1837.s1.e2", "normalized": [] }, { "id": "DS.d1837.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1837.s1.e0", "arg2_id": "DS.d1837.s1.e1", "normalized": [] } ]
DS.d1838
18937360
[ { "id": "DS.d1838.s0", "type": "", "text": [ "Cholesterol promotes basal and verapamil-induced ATPase activity of P-glycoprotein (P-gp)." ], "offsets": [ [ 0, 90 ] ] } ]
[ { "id": "DS.d1838.s0.e0", "type": "compound", "text": [ "verapamil" ], "offsets": [ [ 31, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2520" } ] }, { "id": "DS.d1838.s0.e1", "type": "protein", "text": [ "glycoprotein" ], "offsets": [ [ 70, 82 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] } ]
[]
[]
[ { "id": "DS.d1838.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1838.s0.e0", "arg2_id": "DS.d1838.s0.e1", "normalized": [] } ]
DS.d1839
18937368
[ { "id": "DS.d1839.s0", "type": "", "text": [ "Elucidation of the human serum albumin (HSA) binding site for the Cu-PTSM and Cu-ATSM radiopharmaceuticals." ], "offsets": [ [ 0, 107 ] ] }, { "id": "DS.d1839.s1", "type": "", "text": [ "This study examines the structural basis for HSA binding of Cu-PTSM and Cu-ATSM via competition with drugs having known albumin binding sites." ], "offsets": [ [ 108, 250 ] ] }, { "id": "DS.d1839.s2", "type": "", "text": [ "Cu-ATSM from HSA." ], "offsets": [ [ 251, 268 ] ] }, { "id": "DS.d1839.s3", "type": "", "text": [ "At 8:1 warfarin: HSA Cu-ATSM levels increased 300-500%." ], "offsets": [ [ 269, 324 ] ] }, { "id": "DS.d1839.s4", "type": "", "text": [ "Cu-ATSM was observed except at high ibuprofen: HSA ratios, where secondary ibuprofen binding to the IIA site may cause modest radiopharmaceutical displacement." ], "offsets": [ [ 325, 484 ] ] } ]
[ { "id": "DS.d1839.s0.e0", "type": "protein", "text": [ "serum albumin" ], "offsets": [ [ 25, 38 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P83517" } ] }, { "id": "DS.d1839.s0.e1", "type": "protein", "text": [ "HSA" ], "offsets": [ [ 40, 43 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24807" }, { "db_name": "UniProt", "db_id": "Q07490" } ] }, { "id": "DS.d1839.s0.e2", "type": "compound", "text": [ "Cu-PTSM" ], "offsets": [ [ 66, 73 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9552058" } ] }, { "id": "DS.d1839.s0.e3", "type": "compound", "text": [ "Cu-ATSM" ], "offsets": [ [ 78, 85 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6409958" } ] }, { "id": "DS.d1839.s1.e0", "type": "protein", "text": [ "HSA" ], "offsets": [ [ 153, 156 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24807" }, { "db_name": "UniProt", "db_id": "Q07490" } ] }, { "id": "DS.d1839.s1.e1", "type": "compound", "text": [ "Cu-PTSM" ], "offsets": [ [ 168, 175 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9552058" } ] }, { "id": "DS.d1839.s1.e2", "type": "compound", "text": [ "Cu-ATSM" ], "offsets": [ [ 180, 187 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6409958" } ] }, { "id": "DS.d1839.s2.e0", "type": "compound", "text": [ "Cu-ATSM" ], "offsets": [ [ 251, 258 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6409958" } ] }, { "id": "DS.d1839.s2.e1", "type": "protein", "text": [ "HSA" ], "offsets": [ [ 264, 267 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24807" }, { "db_name": "UniProt", "db_id": "Q07490" } ] }, { "id": "DS.d1839.s3.e0", "type": "protein", "text": [ "HSA" ], "offsets": [ [ 286, 289 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24807" }, { "db_name": "UniProt", "db_id": "Q07490" } ] }, { "id": "DS.d1839.s3.e1", "type": "compound", "text": [ "Cu-ATSM" ], "offsets": [ [ 290, 297 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6409958" } ] }, { "id": "DS.d1839.s4.e0", "type": "compound", "text": [ "Cu-ATSM" ], "offsets": [ [ 325, 332 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6409958" } ] }, { "id": "DS.d1839.s4.e1", "type": "protein", "text": [ "HSA" ], "offsets": [ [ 372, 375 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24807" }, { "db_name": "UniProt", "db_id": "Q07490" } ] } ]
[]
[]
[ { "id": "DS.d1839.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1839.s0.e3", "arg2_id": "DS.d1839.s0.e0", "normalized": [] }, { "id": "DS.d1839.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1839.s0.e2", "arg2_id": "DS.d1839.s0.e0", "normalized": [] }, { "id": "DS.d1839.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1839.s0.e2", "arg2_id": "DS.d1839.s0.e1", "normalized": [] }, { "id": "DS.d1839.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1839.s0.e3", "arg2_id": "DS.d1839.s0.e1", "normalized": [] }, { "id": "DS.d1839.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1839.s1.e1", "arg2_id": "DS.d1839.s1.e0", "normalized": [] }, { "id": "DS.d1839.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1839.s1.e2", "arg2_id": "DS.d1839.s1.e0", "normalized": [] }, { "id": "DS.d1839.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1839.s2.e0", "arg2_id": "DS.d1839.s2.e1", "normalized": [] }, { "id": "DS.d1839.s3.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1839.s3.e1", "arg2_id": "DS.d1839.s3.e0", "normalized": [] } ]
DS.d1841
18937625
[ { "id": "DS.d1841.s0", "type": "", "text": [ "0.05) in the overall glucose-mediated insulin response." ], "offsets": [ [ 0, 55 ] ] }, { "id": "DS.d1841.s1", "type": "", "text": [ "Glucose-stimulated insulin levels were not significantly different from controls." ], "offsets": [ [ 56, 137 ] ] } ]
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[]
[]
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DS.d1842
18937643
[ { "id": "DS.d1842.s0", "type": "", "text": [ "The inducible form of nitric oxide synthase (NOS2) plays an important role in sepsis incurred as a result of infection with Gram-negative bacteria that elaborate endotoxin." ], "offsets": [ [ 0, 172 ] ] } ]
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[]
[]
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DS.d1843
18937645
[ { "id": "DS.d1843.s0", "type": "", "text": [ "Atypical sialylated N-glycan structures are attached to neuronal voltage-gated potassium channels." ], "offsets": [ [ 0, 98 ] ] }, { "id": "DS.d1843.s1", "type": "", "text": [ "Sialic acid linkages were identified for voltage-gated potassium channels, Kv3.1, 3.3, 3.4, 1.1, 1.2 and 1.4, by evaluating their electrophoretic migration patterns in adult rat brain membranes digested with various glycosidases." ], "offsets": [ [ 99, 328 ] ] } ]
[ { "id": "DS.d1843.s0.e0", "type": "compound", "text": [ "glycan" ], "offsets": [ [ 22, 28 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "871" } ] }, { "id": "DS.d1843.s0.e1", "type": "protein", "text": [ "voltage-gated potassium channels" ], "offsets": [ [ 65, 97 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0A333" }, { "db_name": "UniProt", "db_id": "P0A334" }, { "db_name": "UniProt", "db_id": "Q9YDF8" } ] }, { "id": "DS.d1843.s1.e0", "type": "compound", "text": [ "Sialic acid" ], "offsets": [ [ 99, 110 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "906" }, { "db_name": "PubChem", "db_id": "444885" }, { "db_name": "PubChem", "db_id": "445063" } ] }, { "id": "DS.d1843.s1.e1", "type": "protein", "text": [ "voltage-gated potassium channels" ], "offsets": [ [ 140, 172 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0A333" }, { "db_name": "UniProt", "db_id": "P0A334" }, { "db_name": "UniProt", "db_id": "Q9YDF8" } ] } ]
[]
[]
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DS.d1844
18937879
[ { "id": "DS.d1844.s0", "type": "", "text": [ "No regional difference in dopamine D2 receptor occupancy by the second-generation antipsychotic drug risperidone in humans: a positron emission tomography study." ], "offsets": [ [ 0, 161 ] ] }, { "id": "DS.d1844.s1", "type": "", "text": [ "In this study, regional distribution of dopamine D2 receptor occupancy by risperidone was determined in order to elucidate the limbic and cortical selectivity of second-generation antipsychotics." ], "offsets": [ [ 162, 357 ] ] }, { "id": "DS.d1844.s2", "type": "", "text": [ "Striatal and extrastriatal dopamine D2 receptor binding FLB 457, respectively." ], "offsets": [ [ 358, 436 ] ] } ]
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[]
[]
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DS.d1845
18937971
[ { "id": "DS.d1845.s0", "type": "", "text": [ "TP53, BCL-2 and BAX analysis in 199 ovarian cancer patients treated with taxane-platinum regimens." ], "offsets": [ [ 0, 98 ] ] } ]
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[]
[]
[]
DS.d1846
18938111
[ { "id": "DS.d1846.s0", "type": "", "text": [ "NOD2, an intracellular sensor of bacteria-derived muramyl dipeptide (MDP) has been implicated as a key player in intestinal immune health and disease." ], "offsets": [ [ 0, 150 ] ] } ]
[ { "id": "DS.d1846.s0.e0", "type": "protein", "text": [ "NOD2" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9HC29" } ] }, { "id": "DS.d1846.s0.e1", "type": "compound", "text": [ "muramyl dipeptide" ], "offsets": [ [ 50, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "40846" }, { "db_name": "PubChem", "db_id": "451714" }, { "db_name": "PubChem", "db_id": "11620162" } ] } ]
[]
[]
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DS.d1849
18938142
[ { "id": "DS.d1849.s0", "type": "", "text": [ "Exposure of HEK293 cells to BK produced a concentration-dependent rise in intracellular Ca(2+) (EC(50)=36.5+/-8.0 x 10(-9)M), a rapid increase in tyrosine phosphorylation of ERK (EC(50)=9.8+/-0.4 x 10(-9)M), and elevation in ECAR by approximately 20%." ], "offsets": [ [ 0, 251 ] ] } ]
[ { "id": "DS.d1849.s0.e0", "type": "compound", "text": [ "tyrosine" ], "offsets": [ [ 146, 154 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1153" }, { "db_name": "PubChem", "db_id": "6057" }, { "db_name": "PubChem", "db_id": "5460803" } ] }, { "id": "DS.d1849.s0.e1", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 174, 177 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] } ]
[]
[]
[ { "id": "DS.d1849.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1849.s0.e0", "arg2_id": "DS.d1849.s0.e1", "normalized": [] } ]
DS.d1850
18938163
[ { "id": "DS.d1850.s0", "type": "", "text": [ "IGF-I expression coupled with infusion of the IGF binding protein inhibitor NBI-31772 significantly prevented corticospinal motor neuron death 0.05), but did not promote corticospinal axon regeneration." ], "offsets": [ [ 0, 202 ] ] } ]
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[]
[]
[ { "id": "DS.d1850.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1850.s0.e1", "arg2_id": "DS.d1850.s0.e0", "normalized": [] } ]
DS.d1851
18938187
[ { "id": "DS.d1851.s0", "type": "", "text": [ "A significant decrease was observed in GABA (A) alpha(1), GAD (67), and CRF, but not NR2A, mRNAs in adult rats that consumed ethanol in comparison to controls." ], "offsets": [ [ 0, 159 ] ] } ]
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[]
[]
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DS.d1852
18938240
[ { "id": "DS.d1852.s0", "type": "", "text": [ "We showed previously that activation of the angiotensin type 1 receptor (AT1R), which belongs to the G protein-coupled receptor (GPCR) family, leads to c-Src-dependent tyrosine phosphorylation of beta2-adaptin, a subunit of the clathrin adaptor AP-2." ], "offsets": [ [ 0, 250 ] ] } ]
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[]
[]
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DS.d1854
18939895
[ { "id": "DS.d1854.s0", "type": "", "text": [ "Genotoxic effect of 2,4,6-trichlorophenol on p53 gene in zebrafish liver." ], "offsets": [ [ 0, 73 ] ] } ]
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[]
[]
[ { "id": "DS.d1854.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1854.s0.e0", "arg2_id": "DS.d1854.s0.e1", "normalized": [] } ]
DS.d1855
18940183
[ { "id": "DS.d1855.s0", "type": "", "text": [ "Extensive neutrophil infiltration and chemoattractant factor interleukin 8 (IL-8) expression in IL-10 KO mice were observed after halothane administration." ], "offsets": [ [ 0, 155 ] ] }, { "id": "DS.d1855.s1", "type": "", "text": [ "In addition, increased signal transducer and activator of transcription factors (STAT) 1 and STAT3 were observed in halothane treated IL-10 KO mice." ], "offsets": [ [ 156, 304 ] ] } ]
[ { "id": "DS.d1855.s0.e0", "type": "protein", "text": [ "interleukin 8" ], "offsets": [ [ 61, 74 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10145" } ] }, { "id": "DS.d1855.s0.e1", "type": "protein", "text": [ "IL-8" ], "offsets": [ [ 76, 80 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62812" }, { "db_name": "UniProt", "db_id": "P08317" }, { "db_name": "UniProt", "db_id": "P10145" }, { "db_name": "UniProt", "db_id": "P19874" }, { "db_name": "UniProt", "db_id": "P26894" }, { "db_name": "UniProt", "db_id": "P36925" }, { "db_name": "UniProt", "db_id": "P41324" }, { "db_name": "UniProt", "db_id": "P46653" }, { "db_name": "UniProt", "db_id": "P49113" }, { "db_name": "UniProt", "db_id": "P67813" }, { "db_name": "UniProt", "db_id": "P67814" }, { "db_name": "UniProt", "db_id": "P79255" }, { "db_name": "UniProt", "db_id": "Q102R3" }, { "db_name": "UniProt", "db_id": "Q7YRB5" }, { "db_name": "UniProt", "db_id": "Q9XSX5" } ] }, { "id": "DS.d1855.s0.e2", "type": "compound", "text": [ "halothane" ], "offsets": [ [ 130, 139 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3562" } ] }, { "id": "DS.d1855.s1.e0", "type": "protein", "text": [ "STAT" ], "offsets": [ [ 237, 241 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08457" }, { "db_name": "UniProt", "db_id": "P35610" }, { "db_name": "UniProt", "db_id": "Q7QDU4" } ] }, { "id": "DS.d1855.s1.e1", "type": "protein", "text": [ "STAT3" ], "offsets": [ [ 249, 254 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P40763" }, { "db_name": "UniProt", "db_id": "P61635" } ] }, { "id": "DS.d1855.s1.e2", "type": "compound", "text": [ "halothane" ], "offsets": [ [ 272, 281 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3562" } ] } ]
[]
[]
[ { "id": "DS.d1855.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1855.s0.e2", "arg2_id": "DS.d1855.s0.e1", "normalized": [] }, { "id": "DS.d1855.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1855.s0.e2", "arg2_id": "DS.d1855.s0.e0", "normalized": [] }, { "id": "DS.d1855.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1855.s1.e2", "arg2_id": "DS.d1855.s1.e0", "normalized": [] }, { "id": "DS.d1855.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1855.s1.e2", "arg2_id": "DS.d1855.s1.e1", "normalized": [] } ]
DS.d1857
18940188
[ { "id": "DS.d1857.s0", "type": "", "text": [ "Interaction of glutathione peroxidase-1 and selenium in endemic dilated cardiomyopathy." ], "offsets": [ [ 0, 87 ] ] }, { "id": "DS.d1857.s1", "type": "", "text": [ "We studied the gene-environment interaction in the pathogenesis of KD by assessing the association of low blood selenium and polymorphisms in glutathione peroxidase-1 (GPx-1) gene." ], "offsets": [ [ 88, 268 ] ] } ]
[ { "id": "DS.d1857.s0.e0", "type": "protein", "text": [ "glutathione peroxidase-1" ], "offsets": [ [ 15, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O23970" }, { "db_name": "UniProt", "db_id": "P00435" }, { "db_name": "UniProt", "db_id": "P04041" }, { "db_name": "UniProt", "db_id": "P07203" }, { "db_name": "UniProt", "db_id": "P11352" }, { "db_name": "UniProt", "db_id": "P11909" }, { "db_name": "UniProt", "db_id": "P36014" }, { "db_name": "UniProt", "db_id": "Q4AEI1" }, { "db_name": "UniProt", "db_id": "Q4AEI2" }, { "db_name": "UniProt", "db_id": "Q4AEI3" }, { "db_name": "UniProt", "db_id": "Q865R2" }, { "db_name": "UniProt", "db_id": "Q8MJ14" } ] }, { "id": "DS.d1857.s0.e1", "type": "compound", "text": [ "selenium" ], "offsets": [ [ 44, 52 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6326970" } ] }, { "id": "DS.d1857.s1.e0", "type": "compound", "text": [ "selenium" ], "offsets": [ [ 200, 208 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "6326970" } ] }, { "id": "DS.d1857.s1.e1", "type": "protein", "text": [ "glutathione peroxidase-1" ], "offsets": [ [ 230, 254 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O23970" }, { "db_name": "UniProt", "db_id": "P00435" }, { "db_name": "UniProt", "db_id": "P04041" }, { "db_name": "UniProt", "db_id": "P07203" }, { "db_name": "UniProt", "db_id": "P11352" }, { "db_name": "UniProt", "db_id": "P11909" }, { "db_name": "UniProt", "db_id": "P36014" }, { "db_name": "UniProt", "db_id": "Q4AEI1" }, { "db_name": "UniProt", "db_id": "Q4AEI2" }, { "db_name": "UniProt", "db_id": "Q4AEI3" }, { "db_name": "UniProt", "db_id": "Q865R2" }, { "db_name": "UniProt", "db_id": "Q8MJ14" } ] }, { "id": "DS.d1857.s1.e2", "type": "protein", "text": [ "GPx-1" ], "offsets": [ [ 256, 261 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00435" }, { "db_name": "UniProt", "db_id": "P04041" }, { "db_name": "UniProt", "db_id": "P07203" }, { "db_name": "UniProt", "db_id": "P11352" }, { "db_name": "UniProt", "db_id": "P11909" }, { "db_name": "UniProt", "db_id": "Q4AEI1" }, { "db_name": "UniProt", "db_id": "Q4AEI2" }, { "db_name": "UniProt", "db_id": "Q4AEI3" }, { "db_name": "UniProt", "db_id": "Q865R2" }, { "db_name": "UniProt", "db_id": "Q8MJ14" } ] } ]
[]
[]
[ { "id": "DS.d1857.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1857.s0.e1", "arg2_id": "DS.d1857.s0.e0", "normalized": [] }, { "id": "DS.d1857.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1857.s1.e0", "arg2_id": "DS.d1857.s1.e1", "normalized": [] }, { "id": "DS.d1857.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1857.s1.e0", "arg2_id": "DS.d1857.s1.e2", "normalized": [] } ]
DS.d1858
18940204
[ { "id": "DS.d1858.s0", "type": "", "text": [ "However, under the pressure of a death stimulus such as edelfosine treatment, L. infantum EndoG is released from the single mitochondrion and translocates to the nucleus, where it is thought to participate in the process of DNA degradation that is associated with programmed cell death." ], "offsets": [ [ 0, 286 ] ] } ]
[ { "id": "DS.d1858.s0.e0", "type": "compound", "text": [ "edelfosine" ], "offsets": [ [ 56, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1393" } ] }, { "id": "DS.d1858.s0.e1", "type": "protein", "text": [ "EndoG" ], "offsets": [ [ 90, 95 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08600" }, { "db_name": "UniProt", "db_id": "P38447" }, { "db_name": "UniProt", "db_id": "Q14249" }, { "db_name": "UniProt", "db_id": "Q95NM6" } ] } ]
[]
[]
[ { "id": "DS.d1858.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1858.s0.e0", "arg2_id": "DS.d1858.s0.e1", "normalized": [] } ]
DS.d1859
18940228
[ { "id": "DS.d1859.s0", "type": "", "text": [ "Results revealed that HCH administration lead to an increase in hepatic lipid peroxidation associated with reduction in, levels of glutathione (GSH), activity of superoxide dismutase (SOD), catalase and glucose-6-phosphate dehydrogenase." ], "offsets": [ [ 0, 237 ] ] } ]
[ { "id": "DS.d1859.s0.e0", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 131, 142 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d1859.s0.e1", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 144, 147 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d1859.s0.e2", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 162, 182 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d1859.s0.e3", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 184, 187 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] }, { "id": "DS.d1859.s0.e4", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 190, 198 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { "db_name": "UniProt", "db_id": "P04762" }, { "db_name": "UniProt", "db_id": "P07145" }, { "db_name": "UniProt", "db_id": "P0A323" }, { "db_name": "UniProt", "db_id": "P0A324" }, { "db_name": "UniProt", "db_id": "P0A325" }, { "db_name": "UniProt", "db_id": "P0A326" }, { "db_name": "UniProt", "db_id": "P0A327" }, { "db_name": "UniProt", "db_id": "P11934" }, { "db_name": "UniProt", "db_id": "P17336" }, { "db_name": "UniProt", "db_id": "P24168" }, { "db_name": "UniProt", "db_id": "P24270" }, { "db_name": "UniProt", "db_id": "P25890" }, { "db_name": "UniProt", "db_id": "P29422" }, { "db_name": "UniProt", "db_id": "P30265" }, { "db_name": "UniProt", "db_id": "P30266" }, { "db_name": "UniProt", "db_id": "P32290" }, { "db_name": "UniProt", "db_id": "P42321" }, { "db_name": "UniProt", "db_id": "P44390" }, { "db_name": "UniProt", "db_id": "P45737" }, { "db_name": "UniProt", "db_id": "P45739" }, { "db_name": "UniProt", "db_id": "P55304" }, { "db_name": "UniProt", "db_id": "P55306" }, { "db_name": "UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] } ]
[]
[]
[]
DS.d1860
18940247
[ { "id": "DS.d1860.s0", "type": "", "text": [ "However, these events were blocked by treatment with the antioxidant, N-acetyl-cysteine (NAC), as well as GCK overexpression." ], "offsets": [ [ 0, 125 ] ] } ]
[ { "id": "DS.d1860.s0.e0", "type": "compound", "text": [ "N-acetyl-cysteine" ], "offsets": [ [ 70, 87 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "581" } ] }, { "id": "DS.d1860.s0.e1", "type": "protein", "text": [ "GCK" ], "offsets": [ [ 106, 109 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P35557" }, { "db_name": "UniProt", "db_id": "Q12851" }, { "db_name": "UniProt", "db_id": "Q61161" } ] } ]
[]
[]
[]
DS.d1862
18940267
[ { "id": "DS.d1862.s0", "type": "", "text": [ "It decreased TG levels in tyloxapol-induced hyperlipidemia and increased high-density lipoprotein cholesterol (HDL-C) and reduced atherogenic index in normotensive rats." ], "offsets": [ [ 0, 169 ] ] } ]
[ { "id": "DS.d1862.s0.e0", "type": "protein", "text": [ "high-density lipoprotein" ], "offsets": [ [ 73, 97 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P81182" } ] }, { "id": "DS.d1862.s0.e1", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 98, 109 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]
[]
[]
[ { "id": "DS.d1862.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1862.s0.e1", "arg2_id": "DS.d1862.s0.e0", "normalized": [] } ]
DS.d1863
18940894
[ { "id": "DS.d1863.s0", "type": "", "text": [ "This analysis reveals TRPCs as major and unsuspected gates of Ca(2+) entry that contribute, depending on context, to activation of transcription factors, apoptosis, vascular contractility, platelet activation, and cardiac hypertrophy, as well as to normal and abnormal cell proliferation." ], "offsets": [ [ 0, 288 ] ] } ]
[ { "id": "DS.d1863.s0.e0", "type": "protein", "text": [ "TRPCs" ], "offsets": [ [ 22, 27 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P25170" } ] }, { "id": "DS.d1863.s0.e1", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 62, 66 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] } ]
[]
[]
[ { "id": "DS.d1863.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1863.s0.e1", "arg2_id": "DS.d1863.s0.e0", "normalized": [] } ]
DS.d1864
18940938
[ { "id": "DS.d1864.s0", "type": "", "text": [ "A single bout of exercise increases glucose uptake and fatty acid oxidation in skeletal muscle, with a corresponding activation of AMP-activated protein kinase (AMPK)." ], "offsets": [ [ 0, 167 ] ] }, { "id": "DS.d1864.s1", "type": "", "text": [ "Changes in oxygen consumption and the RQ ratio during sedentary and low-intensity exercise were not different between alpha(1)-AMPK-DN and WT." ], "offsets": [ [ 168, 310 ] ] } ]
[ { "id": "DS.d1864.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 36, 43 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1864.s0.e1", "type": "protein", "text": [ "protein kinase" ], "offsets": [ [ 145, 159 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00513" }, { "db_name": "UniProt", "db_id": "P25848" } ] }, { "id": "DS.d1864.s0.e2", "type": "protein", "text": [ "AMPK" ], "offsets": [ [ 161, 165 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P54646" }, { "db_name": "UniProt", "db_id": "Q09136" }, { "db_name": "UniProt", "db_id": "Q9Y478" } ] }, { "id": "DS.d1864.s1.e0", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 179, 185 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d1864.s1.e1", "type": "protein", "text": [ "AMPK" ], "offsets": [ [ 295, 299 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P54646" }, { "db_name": "UniProt", "db_id": "Q09136" }, { "db_name": "UniProt", "db_id": "Q9Y478" } ] } ]
[]
[]
[ { "id": "DS.d1864.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1864.s0.e0", "arg2_id": "DS.d1864.s0.e1", "normalized": [] }, { "id": "DS.d1864.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1864.s0.e0", "arg2_id": "DS.d1864.s0.e2", "normalized": [] } ]
DS.d1865
18941142
[ { "id": "DS.d1865.s0", "type": "", "text": [ "ABCA1-mediated cholesterol efflux generates microparticles in addition to HDL through processes governed by membrane rigidity." ], "offsets": [ [ 0, 126 ] ] } ]
[ { "id": "DS.d1865.s0.e0", "type": "protein", "text": [ "ABCA1" ], "offsets": [ [ 0, 5 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O95477" } ] }, { "id": "DS.d1865.s0.e1", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 15, 26 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]
[]
[]
[ { "id": "DS.d1865.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1865.s0.e1", "arg2_id": "DS.d1865.s0.e0", "normalized": [] } ]
DS.d1866
18941467
[ { "id": "DS.d1866.s0", "type": "", "text": [ "DHT treatment, in vivo or ex vivo, increased nuclear NFkappaB activation in cerebral arteries and increased levels of the proinflammatory products of NFkappaB activation, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS)." ], "offsets": [ [ 0, 239 ] ] }, { "id": "DS.d1866.s1", "type": "", "text": [ "Effects of DHT on COX-2 and iNOS were attenuated by flutamide." ], "offsets": [ [ 240, 302 ] ] }, { "id": "DS.d1866.s2", "type": "", "text": [ "In conclusion, activation of the NFkappaB-mediated COX-2/iNOS pathway by the selective androgen receptor agonist, DHT, results in a state of vascular inflammation." ], "offsets": [ [ 303, 466 ] ] } ]
[ { "id": "DS.d1866.s0.e0", "type": "compound", "text": [ "DHT" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10635" } ] }, { "id": "DS.d1866.s0.e1", "type": "protein", "text": [ "cyclooxygenase-2" ], "offsets": [ [ 171, 187 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d1866.s0.e2", "type": "protein", "text": [ "COX-2" ], "offsets": [ [ 189, 194 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d1866.s0.e3", "type": "protein", "text": [ "nitric oxide synthase" ], "offsets": [ [ 210, 231 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q27571" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d1866.s0.e4", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 233, 237 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d1866.s1.e0", "type": "compound", "text": [ "DHT" ], "offsets": [ [ 251, 254 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10635" } ] }, { "id": "DS.d1866.s1.e1", "type": "protein", "text": [ "COX-2" ], "offsets": [ [ 258, 263 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d1866.s1.e2", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 268, 272 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d1866.s1.e3", "type": "compound", "text": [ "flutamide" ], "offsets": [ [ 292, 301 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3397" } ] }, { "id": "DS.d1866.s2.e0", "type": "protein", "text": [ "COX-2" ], "offsets": [ [ 354, 359 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] }, { "id": "DS.d1866.s2.e1", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 360, 364 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d1866.s2.e2", "type": "compound", "text": [ "DHT" ], "offsets": [ [ 417, 420 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10635" } ] } ]
[]
[]
[ { "id": "DS.d1866.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1866.s0.e0", "arg2_id": "DS.d1866.s0.e1", "normalized": [] }, { "id": "DS.d1866.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1866.s0.e0", "arg2_id": "DS.d1866.s0.e4", "normalized": [] }, { "id": "DS.d1866.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1866.s0.e0", "arg2_id": "DS.d1866.s0.e3", "normalized": [] }, { "id": "DS.d1866.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1866.s0.e0", "arg2_id": "DS.d1866.s0.e2", "normalized": [] }, { "id": "DS.d1866.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1866.s1.e0", "arg2_id": "DS.d1866.s1.e2", "normalized": [] }, { "id": "DS.d1866.s1.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1866.s1.e0", "arg2_id": "DS.d1866.s1.e1", "normalized": [] }, { "id": "DS.d1866.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1866.s2.e2", "arg2_id": "DS.d1866.s2.e1", "normalized": [] }, { "id": "DS.d1866.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1866.s2.e2", "arg2_id": "DS.d1866.s2.e0", "normalized": [] } ]
DS.d1867
18941468
[ { "id": "DS.d1867.s0", "type": "", "text": [ "After MRI, one group of animals had BBB permeability measured in the WM with (14)C-sucrose, and another had Evans blue (EB) injected for fluorescent microscopy for MMP-2, MMP-9, tight junction proteins (TJPs), and in situ zymography." ], "offsets": [ [ 0, 233 ] ] } ]
[ { "id": "DS.d1867.s0.e0", "type": "compound", "text": [ "sucrose" ], "offsets": [ [ 83, 90 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5988" } ] }, { "id": "DS.d1867.s0.e1", "type": "compound", "text": [ "Evans blue" ], "offsets": [ [ 108, 118 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5356750" }, { "db_name": "PubChem", "db_id": "6913958" }, { "db_name": "PubChem", "db_id": "9566058" } ] }, { "id": "DS.d1867.s0.e2", "type": "protein", "text": [ "MMP-2" ], "offsets": [ [ 164, 169 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08253" }, { "db_name": "UniProt", "db_id": "P33434" }, { "db_name": "UniProt", "db_id": "P33436" }, { "db_name": "UniProt", "db_id": "P50757" }, { "db_name": "UniProt", "db_id": "Q90611" }, { "db_name": "UniProt", "db_id": "Q9GLE5" } ] }, { "id": "DS.d1867.s0.e3", "type": "protein", "text": [ "MMP-9" ], "offsets": [ [ 171, 176 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18733" }, { "db_name": "UniProt", "db_id": "P14780" }, { "db_name": "UniProt", "db_id": "P41245" }, { "db_name": "UniProt", "db_id": "P41246" }, { "db_name": "UniProt", "db_id": "P50282" }, { "db_name": "UniProt", "db_id": "P52176" } ] } ]
[]
[]
[]
DS.d1868
18941714
[ { "id": "DS.d1868.s0", "type": "", "text": [ "The electrons released from NADPH by CPR were transferred to CTC in the reaction medium, and CTC reduction activity could be assessed spectrophotometrically and spectrofluorometrically." ], "offsets": [ [ 0, 185 ] ] } ]
[ { "id": "DS.d1868.s0.e0", "type": "compound", "text": [ "NADPH" ], "offsets": [ [ 28, 33 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5884" } ] }, { "id": "DS.d1868.s0.e1", "type": "protein", "text": [ "CPR" ], "offsets": [ [ 37, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00388" }, { "db_name": "UniProt", "db_id": "P00389" }, { "db_name": "UniProt", "db_id": "P04175" }, { "db_name": "UniProt", "db_id": "P16435" }, { "db_name": "UniProt", "db_id": "P16603" }, { "db_name": "UniProt", "db_id": "P19618" }, { "db_name": "UniProt", "db_id": "P36587" }, { "db_name": "UniProt", "db_id": "P37039" }, { "db_name": "UniProt", "db_id": "P37040" }, { "db_name": "UniProt", "db_id": "P37116" }, { "db_name": "UniProt", "db_id": "P37201" }, { "db_name": "UniProt", "db_id": "P50126" }, { "db_name": "UniProt", "db_id": "Q00141" }, { "db_name": "UniProt", "db_id": "Q05001" }, { "db_name": "UniProt", "db_id": "Q07994" }, { "db_name": "UniProt", "db_id": "Q27597" }, { "db_name": "UniProt", "db_id": "Q3SYT8" }, { "db_name": "UniProt", "db_id": "Q9EQV9" }, { "db_name": "UniProt", "db_id": "Q9HDG2" }, { "db_name": "UniProt", "db_id": "Q9JHH6" } ] } ]
[]
[]
[ { "id": "DS.d1868.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1868.s0.e0", "arg2_id": "DS.d1868.s0.e1", "normalized": [] } ]
DS.d1870
18941797
[ { "id": "DS.d1870.s0", "type": "", "text": [ "Effects of dissolved oxygen tension and agitation rate on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors." ], "offsets": [ [ 0, 178 ] ] } ]
[ { "id": "DS.d1870.s0.e0", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 21, 27 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d1870.s0.e1", "type": "protein", "text": [ "glycoprotein" ], "offsets": [ [ 95, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08163" } ] } ]
[]
[]
[]
DS.d1871
18941818
[ { "id": "DS.d1871.s0", "type": "", "text": [ "Goldfish scales were incubated either with 20:3n-9 or with oleic acid at 15 degrees C for 6 and 18 h. Both osteoblastic and osteoclastic activities in the scale were assessed by measuring alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase, respectively." ], "offsets": [ [ 0, 269 ] ] }, { "id": "DS.d1871.s1", "type": "", "text": [ "MC3T3-E1 cells (an osteoblast cell line derived from the mouse) were incubated with 20:3n-9 or oleic acid at 37 degrees C for 6 and 18 h. ALP activity in cell lysate was measured." ], "offsets": [ [ 270, 449 ] ] } ]
[ { "id": "DS.d1871.s0.e0", "type": "compound", "text": [ "oleic acid" ], "offsets": [ [ 59, 69 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445639" } ] }, { "id": "DS.d1871.s0.e1", "type": "protein", "text": [ "alkaline phosphatase" ], "offsets": [ [ 188, 208 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O60109" }, { "db_name": "UniProt", "db_id": "P81800" }, { "db_name": "UniProt", "db_id": "P83456" } ] }, { "id": "DS.d1871.s0.e2", "type": "protein", "text": [ "ALP" ], "offsets": [ [ 210, 213 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03973" }, { "db_name": "UniProt", "db_id": "P12547" }, { "db_name": "UniProt", "db_id": "P22298" }, { "db_name": "UniProt", "db_id": "P28296" }, { "db_name": "UniProt", "db_id": "P29118" }, { "db_name": "UniProt", "db_id": "P35211" }, { "db_name": "UniProt", "db_id": "P83610" }, { "db_name": "UniProt", "db_id": "P97430" }, { "db_name": "UniProt", "db_id": "Q03420" }, { "db_name": "UniProt", "db_id": "Q53GG5" }, { "db_name": "UniProt", "db_id": "Q9H0A0" }, { "db_name": "UniProt", "db_id": "Q9PU47" }, { "db_name": "UniProt", "db_id": "Q9Z1X0" } ] }, { "id": "DS.d1871.s1.e0", "type": "compound", "text": [ "oleic acid" ], "offsets": [ [ 365, 375 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "445639" } ] }, { "id": "DS.d1871.s1.e1", "type": "protein", "text": [ "ALP" ], "offsets": [ [ 408, 411 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P03973" }, { "db_name": "UniProt", "db_id": "P12547" }, { "db_name": "UniProt", "db_id": "P22298" }, { "db_name": "UniProt", "db_id": "P28296" }, { "db_name": "UniProt", "db_id": "P29118" }, { "db_name": "UniProt", "db_id": "P35211" }, { "db_name": "UniProt", "db_id": "P83610" }, { "db_name": "UniProt", "db_id": "P97430" }, { "db_name": "UniProt", "db_id": "Q03420" }, { "db_name": "UniProt", "db_id": "Q53GG5" }, { "db_name": "UniProt", "db_id": "Q9H0A0" }, { "db_name": "UniProt", "db_id": "Q9PU47" }, { "db_name": "UniProt", "db_id": "Q9Z1X0" } ] } ]
[]
[]
[]
DS.d1872
18941890
[ { "id": "DS.d1872.s0", "type": "", "text": [ "Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha." ], "offsets": [ [ 0, 96 ] ] }, { "id": "DS.d1872.s1", "type": "", "text": [ "Both kinases have been implicated in the phosphorylation of serine 118 and serine 167 on ERalpha, respectively." ], "offsets": [ [ 97, 208 ] ] }, { "id": "DS.d1872.s2", "type": "", "text": [ "Our data show for the first time that ROS can induce post-translational modifications of ERalpha at serine 118 and serine 167, and may lead to ERalpha down-regulation in human breast cancer cells." ], "offsets": [ [ 209, 405 ] ] } ]
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{ "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d1872.s1.e0", "type": "compound", "text": [ "serine" ], "offsets": [ [ 157, 163 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5951" } ] }, { "id": "DS.d1872.s1.e1", "type": "compound", "text": [ "serine" ], "offsets": [ [ 172, 178 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5951" } ] }, { "id": "DS.d1872.s1.e2", "type": "protein", "text": [ "ERalpha" ], "offsets": [ [ 186, 193 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d1872.s2.e0", "type": "protein", "text": [ "ERalpha" ], "offsets": [ [ 298, 305 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d1872.s2.e1", "type": "compound", "text": [ "serine" ], "offsets": [ [ 309, 315 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5951" } ] }, { "id": "DS.d1872.s2.e2", "type": "compound", "text": [ "serine" ], "offsets": [ [ 324, 330 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5951" } ] }, { "id": "DS.d1872.s2.e3", "type": "protein", "text": [ "ERalpha" ], "offsets": [ [ 352, 359 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06211" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P19785" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57717" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "P81559" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHT3" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] } ]
[]
[]
[ { "id": "DS.d1872.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1872.s0.e0", "arg2_id": "DS.d1872.s0.e1", "normalized": [] }, { "id": "DS.d1872.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1872.s1.e0", "arg2_id": "DS.d1872.s1.e2", "normalized": [] }, { "id": "DS.d1872.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1872.s2.e1", "arg2_id": "DS.d1872.s2.e0", "normalized": [] } ]
DS.d1873
18942092
[ { "id": "DS.d1873.s0", "type": "", "text": [ "Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy." ], "offsets": [ [ 0, 146 ] ] } ]
[ { "id": "DS.d1873.s0.e0", "type": "protein", "text": [ "EGFR" ], "offsets": [ [ 104, 108 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00533" }, { "db_name": "UniProt", "db_id": "P13387" }, { "db_name": "UniProt", "db_id": "P55245" } ] }, { "id": "DS.d1873.s0.e1", "type": "compound", "text": [ "docetaxel" ], "offsets": [ [ 123, 132 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "148124" } ] } ]
[]
[]
[]
DS.d1874
18942097
[ { "id": "DS.d1874.s0", "type": "", "text": [ "Expression of the histone H2B-GFP fusion protein was observed exclusively upon doxycycline induction and was uniformly distributed throughout the intestinal epithelium." ], "offsets": [ [ 0, 168 ] ] } ]
[ { "id": "DS.d1874.s0.e0", "type": "protein", "text": [ "histone H2B" ], "offsets": [ [ 18, 29 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O22582" }, { "db_name": "UniProt", "db_id": "O49118" }, { "db_name": "UniProt", "db_id": "O97484" }, { "db_name": "UniProt", "db_id": "P02280" }, { "db_name": "UniProt", "db_id": "P02283" }, { "db_name": "UniProt", "db_id": "P14001" }, { "db_name": "UniProt", "db_id": "P17271" }, { "db_name": "UniProt", "db_id": "P19374" }, { "db_name": "UniProt", "db_id": "P21897" }, { "db_name": "UniProt", "db_id": "P23754" }, { "db_name": "UniProt", "db_id": "P27326" }, { "db_name": "UniProt", "db_id": "P27795" }, { "db_name": "UniProt", "db_id": "P27893" }, { "db_name": "UniProt", "db_id": "P30757" }, { "db_name": "UniProt", "db_id": "P35067" }, { "db_name": "UniProt", "db_id": "P37210" }, { "db_name": "UniProt", "db_id": "P40284" }, { "db_name": "UniProt", "db_id": "P48557" }, { "db_name": "UniProt", "db_id": "P59781" }, { "db_name": "UniProt", "db_id": "P59782" }, { "db_name": "UniProt", "db_id": "P69069" }, { "db_name": "UniProt", "db_id": "P69070" }, { "db_name": "UniProt", "db_id": "P78567" }, { "db_name": "UniProt", "db_id": "P82887" }, { "db_name": "UniProt", "db_id": "P83837" }, { "db_name": "UniProt", "db_id": "P83863" }, { "db_name": "UniProt", "db_id": "P93354" }, { "db_name": "UniProt", "db_id": "Q27442" }, { "db_name": "UniProt", "db_id": "Q2HH38" }, { "db_name": "UniProt", "db_id": "Q2U5A9" }, { "db_name": "UniProt", "db_id": "Q4HTT2" }, { "db_name": "UniProt", "db_id": "Q4PEF8" }, { "db_name": "UniProt", "db_id": "Q4WWC5" }, { "db_name": "UniProt", "db_id": "Q5G577" }, { "db_name": "UniProt", "db_id": "Q5KMT4" }, { "db_name": "UniProt", "db_id": "Q6C4I7" }, { "db_name": "UniProt", "db_id": "Q75VN4" }, { "db_name": "UniProt", "db_id": "Q76FD7" }, { "db_name": "UniProt", "db_id": "Q76FE5" }, { "db_name": "UniProt", "db_id": "Q76FE9" }, { "db_name": "UniProt", "db_id": "Q76FF3" }, { "db_name": "UniProt", "db_id": "Q7M400" }, { "db_name": "UniProt", "db_id": "Q7M4G7" }, { "db_name": "UniProt", "db_id": "Q7Z9J4" }, { "db_name": "UniProt", "db_id": "Q875B7" }, { "db_name": "UniProt", "db_id": "Q8I1N0" }, { "db_name": "UniProt", "db_id": "Q8J1K2" }, { "db_name": "UniProt", "db_id": "Q8SRE2" }, { "db_name": "UniProt", "db_id": "Q99285" } ] }, { "id": "DS.d1874.s0.e2", "type": "compound", "text": [ "doxycycline" ], "offsets": [ [ 79, 90 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54671203" } ] } ]
[]
[]
[ { "id": "DS.d1874.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1874.s0.e2", "arg2_id": "DS.d1874.s0.e0", "normalized": [] } ]
DS.d1875
18942140
[ { "id": "DS.d1875.s0", "type": "", "text": [ "On hexanoamide the amidase exhibited a K(m) value of 5.5 mM compared to 0.07 mM for p-nitroacetanilide." ], "offsets": [ [ 0, 103 ] ] } ]
[ { "id": "DS.d1875.s0.e0", "type": "compound", "text": [ "hexanoamide" ], "offsets": [ [ 3, 14 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "12332" } ] }, { "id": "DS.d1875.s0.e1", "type": "protein", "text": [ "amidase" ], "offsets": [ [ 19, 26 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O69768" }, { "db_name": "UniProt", "db_id": "P22984" }, { "db_name": "UniProt", "db_id": "P27765" }, { "db_name": "UniProt", "db_id": "P95896" } ] }, { "id": "DS.d1875.s0.e2", "type": "compound", "text": [ "p-nitroacetanilide" ], "offsets": [ [ 84, 102 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "7691" } ] } ]
[]
[]
[ { "id": "DS.d1875.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1875.s0.e2", "arg2_id": "DS.d1875.s0.e1", "normalized": [] }, { "id": "DS.d1875.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1875.s0.e0", "arg2_id": "DS.d1875.s0.e1", "normalized": [] } ]
DS.d1876
18942727
[ { "id": "DS.d1876.s0", "type": "", "text": [ "Recoverin is an important neuronal calcium sensor (NCS) protein, which have been implicated in a wide range of Ca(2+) signaling events in neurons and photoreceptors." ], "offsets": [ [ 0, 165 ] ] } ]
[ { "id": "DS.d1876.s0.e0", "type": "protein", "text": [ "Recoverin" ], "offsets": [ [ 0, 9 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21457" }, { "db_name": "UniProt", "db_id": "P34057" }, { "db_name": "UniProt", "db_id": "P35243" } ] }, { "id": "DS.d1876.s0.e1", "type": "protein", "text": [ "NCS" ], "offsets": [ [ 51, 54 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0A3R9" }, { "db_name": "UniProt", "db_id": "P0A3S0" } ] }, { "id": "DS.d1876.s0.e2", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 111, 115 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] } ]
[]
[]
[ { "id": "DS.d1876.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1876.s0.e2", "arg2_id": "DS.d1876.s0.e0", "normalized": [] }, { "id": "DS.d1876.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1876.s0.e2", "arg2_id": "DS.d1876.s0.e1", "normalized": [] } ]
DS.d1877
18942747
[ { "id": "DS.d1877.s1", "type": "", "text": [ "A decrease in P2X (7)R expression was observed in cultured OPCs after exposure to oxygen-glucose deprivation (OGD) for 2 h in vitro." ], "offsets": [ [ 0, 132 ] ] } ]
[ { "id": "DS.d1877.s1.e0", "type": "protein", "text": [ "P2X" ], "offsets": [ [ 14, 17 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13900" }, { "db_name": "UniProt", "db_id": "P16604" } ] }, { "id": "DS.d1877.s1.e2", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 89, 96 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]
[]
[]
[ { "id": "DS.d1877.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1877.s1.e2", "arg2_id": "DS.d1877.s1.e0", "normalized": [] } ]
DS.d1878
18945212
[ { "id": "DS.d1878.s0", "type": "", "text": [ "Reactivity of nitric oxide with the (4Fe-4S) cluster of dihydroxyacid dehydratase from Escherichia coli." ], "offsets": [ [ 0, 104 ] ] }, { "id": "DS.d1878.s1", "type": "", "text": [ "The rate constant for the initial reaction between NO and the IlvD (4Fe-4S) cluster is estimated to be (7.0+/-2.0)x10(6) M(-2) x s(-1) at 25 degrees C, which is approx." ], "offsets": [ [ 105, 273 ] ] } ]
[ { "id": "DS.d1878.s0.e0", "type": "compound", "text": [ "nitric oxide" ], "offsets": [ [ 14, 26 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "145068" } ] }, { "id": "DS.d1878.s0.e2", "type": "protein", "text": [ "dihydroxyacid dehydratase" ], "offsets": [ [ 56, 81 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O06069" }, { "db_name": "UniProt", "db_id": "O27498" }, { "db_name": "UniProt", "db_id": "O29248" }, { "db_name": "UniProt", "db_id": "O51887" }, { "db_name": "UniProt", "db_id": "O67009" }, { "db_name": "UniProt", "db_id": "O69198" }, { "db_name": "UniProt", "db_id": "P05791" }, { "db_name": "UniProt", "db_id": "P31874" }, { "db_name": "UniProt", "db_id": "P31959" }, { "db_name": "UniProt", "db_id": "P40810" }, { "db_name": "UniProt", "db_id": "P44851" }, { "db_name": "UniProt", "db_id": "P51785" }, { "db_name": "UniProt", "db_id": "P55186" }, { "db_name": "UniProt", "db_id": "P57656" }, { "db_name": "UniProt", "db_id": "P57957" }, { "db_name": "UniProt", 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[]
[]
[ { "id": "DS.d1878.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1878.s0.e0", "arg2_id": "DS.d1878.s0.e2", "normalized": [] }, { "id": "DS.d1878.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1878.s1.e1", "arg2_id": "DS.d1878.s1.e0", "normalized": [] } ]
DS.d1880
18945215
[ { "id": "DS.d1880.s0", "type": "", "text": [ "Acylcarnitines have been suggested to play a role in insulin resistance, as well as other long-chain fatty acid metabolites." ], "offsets": [ [ 0, 124 ] ] }, { "id": "DS.d1880.s1", "type": "", "text": [ "In the present study we investigated whether muscle long-chain acylcarnitines increase during fasting and we investigated their relationship with glucose/fat oxidation and insulin sensitivity in lean healthy humans." ], "offsets": [ [ 125, 340 ] ] } ]
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[]
[]
[]
DS.d1881
18945217
[ { "id": "DS.d1881.s0", "type": "", "text": [ "Ethanol attenuates the HFS-induced, ERK-mediated LTP in a dose-dependent manner in rat striatum." ], "offsets": [ [ 0, 96 ] ] } ]
[ { "id": "DS.d1881.s0.e0", "type": "compound", "text": [ "Ethanol" ], "offsets": [ [ 0, 7 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "702" } ] }, { "id": "DS.d1881.s0.e1", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] } ]
[]
[]
[ { "id": "DS.d1881.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1881.s0.e0", "arg2_id": "DS.d1881.s0.e1", "normalized": [] } ]
DS.d1882
18945429
[ { "id": "DS.d1882.s0", "type": "", "text": [ "These results suggest that StAR delivers cholesterol to mitochondria where regulatory oxysterols are generated." ], "offsets": [ [ 0, 111 ] ] } ]
[ { "id": "DS.d1882.s0.e0", "type": "protein", "text": [ "StAR" ], "offsets": [ [ 27, 31 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O46689" }, { "db_name": "UniProt", "db_id": "P49675" }, { "db_name": "UniProt", "db_id": "P51557" }, { "db_name": "UniProt", "db_id": "P58864" }, { "db_name": "UniProt", "db_id": "P70114" }, { "db_name": "UniProt", "db_id": "P79245" }, { "db_name": "UniProt", "db_id": "P97826" }, { "db_name": "UniProt", "db_id": "Q28918" }, { "db_name": "UniProt", "db_id": "Q28996" }, { "db_name": "UniProt", "db_id": "Q9DE06" }, { "db_name": "UniProt", "db_id": "Q9DEB4" }, { "db_name": "UniProt", "db_id": "Q9DG08" }, { "db_name": "UniProt", "db_id": "Q9DG09" }, { "db_name": "UniProt", "db_id": "Q9DG10" } ] }, { "id": "DS.d1882.s0.e1", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 41, 52 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]
[]
[]
[ { "id": "DS.d1882.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1882.s0.e1", "arg2_id": "DS.d1882.s0.e0", "normalized": [] } ]
DS.d1883
18945563
[ { "id": "DS.d1883.s0", "type": "", "text": [ "17beta-Hydroxysteroid dehydrogenase type 1 (HSD17B1) is a key enzyme of 17beta-estradiol biosynthesis, which might play an important role in follicular development of the ovary." ], "offsets": [ [ 0, 177 ] ] } ]
[ { "id": "DS.d1883.s0.e0", "type": "protein", "text": [ "17beta-Hydroxysteroid dehydrogenase type 1" ], "offsets": [ [ 0, 42 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14061" }, { "db_name": "UniProt", "db_id": "P51656" }, { "db_name": "UniProt", "db_id": "P51657" }, { "db_name": "UniProt", "db_id": "Q1WNP0" } ] }, { "id": "DS.d1883.s0.e1", "type": "protein", "text": [ "HSD17B1" ], "offsets": [ [ 44, 51 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P14061" }, { "db_name": "UniProt", "db_id": "Q1WNP0" } ] }, { "id": "DS.d1883.s0.e2", "type": "compound", "text": [ "17beta-estradiol" ], "offsets": [ [ 72, 88 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5757" } ] } ]
[]
[]
[ { "id": "DS.d1883.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1883.s0.e2", "arg2_id": "DS.d1883.s0.e1", "normalized": [] }, { "id": "DS.d1883.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1883.s0.e2", "arg2_id": "DS.d1883.s0.e0", "normalized": [] } ]
DS.d1885
18945611
[ { "id": "DS.d1885.s0", "type": "", "text": [ "MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma." ], "offsets": [ [ 0, 155 ] ] }, { "id": "DS.d1885.s1", "type": "", "text": [ "To investigate the correlation between O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation and benefit from temozolomide in patients with recurrent high-grade glioma." ], "offsets": [ [ 156, 339 ] ] } ]
[ { "id": "DS.d1885.s0.e0", "type": "protein", "text": [ "MGMT" ], "offsets": [ [ 0, 4 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O26715" }, { "db_name": "UniProt", "db_id": "O27970" }, { "db_name": "UniProt", "db_id": "O59499" }, { "db_name": "UniProt", "db_id": "O74023" }, { "db_name": "UniProt", "db_id": "O93728" }, { "db_name": "UniProt", "db_id": "P0A2U0" }, { "db_name": "UniProt", "db_id": "P0A2U1" }, { "db_name": "UniProt", "db_id": "P0A696" }, { "db_name": "UniProt", "db_id": "P0A697" }, { "db_name": "UniProt", "db_id": "P0AFH0" }, { "db_name": "UniProt", "db_id": "P0AFH1" }, { "db_name": "UniProt", "db_id": "P11742" }, { "db_name": "UniProt", "db_id": "P16455" }, { "db_name": "UniProt", "db_id": "P24528" }, { "db_name": "UniProt", "db_id": "P26186" }, { "db_name": "UniProt", "db_id": "P26187" }, { "db_name": "UniProt", "db_id": "P26188" }, { "db_name": "UniProt", "db_id": "P29177" }, { "db_name": "UniProt", "db_id": "P44687" }, { "db_name": "UniProt", "db_id": "P52982" }, { "db_name": "UniProt", "db_id": "Q4J9C6" }, { "db_name": "UniProt", "db_id": "Q58924" }, { "db_name": "UniProt", "db_id": "Q5UNU9" }, { "db_name": "UniProt", "db_id": "Q6TDU1" }, { "db_name": "UniProt", "db_id": "Q8PY44" }, { "db_name": "UniProt", "db_id": "Q8TI34" }, { "db_name": "UniProt", "db_id": "Q8TZ11" }, { "db_name": "UniProt", "db_id": "Q8TZV2" }, { "db_name": "UniProt", "db_id": "Q973C7" }, { "db_name": "UniProt", "db_id": "Q97VW7" }, { "db_name": "UniProt", "db_id": "Q9V1N7" }, { "db_name": "UniProt", "db_id": "Q9ZET8" } ] }, { "id": "DS.d1885.s0.e1", "type": "compound", "text": [ "temozolomide" ], "offsets": [ [ 71, 83 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5394" } ] }, { "id": "DS.d1885.s1.e1", "type": "protein", "text": [ "MGMT" ], "offsets": [ [ 237, 241 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O26715" }, { "db_name": "UniProt", "db_id": "O27970" }, { "db_name": "UniProt", "db_id": "O59499" }, { "db_name": "UniProt", "db_id": "O74023" }, { "db_name": "UniProt", "db_id": "O93728" }, { "db_name": "UniProt", "db_id": "P0A2U0" }, { "db_name": "UniProt", "db_id": "P0A2U1" }, { "db_name": "UniProt", "db_id": "P0A696" }, { "db_name": "UniProt", "db_id": "P0A697" }, { "db_name": "UniProt", "db_id": "P0AFH0" }, { "db_name": "UniProt", "db_id": "P0AFH1" }, { "db_name": "UniProt", "db_id": "P11742" }, { "db_name": "UniProt", "db_id": "P16455" }, { "db_name": "UniProt", "db_id": "P24528" }, { "db_name": "UniProt", "db_id": "P26186" }, { "db_name": "UniProt", "db_id": "P26187" }, { "db_name": "UniProt", "db_id": "P26188" }, { "db_name": "UniProt", "db_id": "P29177" }, { "db_name": "UniProt", "db_id": "P44687" }, { "db_name": "UniProt", "db_id": "P52982" }, { "db_name": "UniProt", "db_id": "Q4J9C6" }, { "db_name": "UniProt", "db_id": "Q58924" }, { "db_name": "UniProt", "db_id": "Q5UNU9" }, { "db_name": "UniProt", "db_id": "Q6TDU1" }, { "db_name": "UniProt", "db_id": "Q8PY44" }, { "db_name": "UniProt", "db_id": "Q8TI34" }, { "db_name": "UniProt", "db_id": "Q8TZ11" }, { "db_name": "UniProt", "db_id": "Q8TZV2" }, { "db_name": "UniProt", "db_id": "Q973C7" }, { "db_name": "UniProt", "db_id": "Q97VW7" }, { "db_name": "UniProt", "db_id": "Q9V1N7" }, { "db_name": "UniProt", "db_id": "Q9ZET8" } ] }, { "id": "DS.d1885.s1.e2", "type": "compound", "text": [ "temozolomide" ], "offsets": [ [ 281, 293 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5394" } ] } ]
[]
[]
[ { "id": "DS.d1885.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1885.s0.e1", "arg2_id": "DS.d1885.s0.e0", "normalized": [] }, { "id": "DS.d1885.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1885.s1.e2", "arg2_id": "DS.d1885.s1.e1", "normalized": [] } ]
DS.d1886
18945624
[ { "id": "DS.d1886.s0", "type": "", "text": [ "Betulinic acid binding to human serum albumin : a study of protein conformation and binding affinity." ], "offsets": [ [ 0, 101 ] ] } ]
[ { "id": "DS.d1886.s0.e0", "type": "compound", "text": [ "Betulinic acid" ], "offsets": [ [ 0, 14 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "64971" } ] }, { "id": "DS.d1886.s0.e1", "type": "protein", "text": [ "serum albumin" ], "offsets": [ [ 32, 45 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21847" }, { "db_name": "UniProt", "db_id": "P83517" } ] } ]
[]
[]
[ { "id": "DS.d1886.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1886.s0.e0", "arg2_id": "DS.d1886.s0.e1", "normalized": [] } ]
DS.d1887
18945756
[ { "id": "DS.d1887.s0", "type": "", "text": [ "Adenosine nucleotide translocase (ANT) translocates ADP/ATP across the inner mitochondrial membrane." ], "offsets": [ [ 0, 100 ] ] } ]
[ { "id": "DS.d1887.s0.e0", "type": "protein", "text": [ "ANT" ], "offsets": [ [ 34, 37 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P02723" }, { "db_name": "UniProt", "db_id": "P25083" }, { "db_name": "UniProt", "db_id": "P27080" }, { "db_name": "UniProt", "db_id": "P27081" }, { "db_name": "UniProt", "db_id": "P31691" }, { "db_name": "UniProt", "db_id": "P31692" }, { "db_name": "UniProt", "db_id": "P49382" }, { "db_name": "UniProt", "db_id": "Q09188" }, { "db_name": "UniProt", "db_id": "Q26365" }, { "db_name": "UniProt", "db_id": "Q38914" } ] }, { "id": "DS.d1887.s0.e1", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 56, 59 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] } ]
[]
[]
[ { "id": "DS.d1887.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1887.s0.e1", "arg2_id": "DS.d1887.s0.e0", "normalized": [] } ]