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DS.d1558 | 18841470 | [
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DS.d1559 | 18841471 | [
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DS.d1560 | 18841529 | [
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DS.d1561 | 18842264 | [
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DS.d1562 | 18842297 | [
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DS.d1563 | 18842335 | [
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DS.d1564 | 18842348 | [
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DS.d1565 | 18842620 | [
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DS.d1566 | 18842703 | [
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DS.d1567 | 18842954 | [
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DS.d1568 | 18842962 | [
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DS.d1569 | 18843259 | [
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DS.d1576 | 18844240 | [
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DS.d1580 | 18844326 | [
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DS.d1584 | 18845237 | [
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DS.d1585 | 18845277 | [
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DS.d1586 | 18845302 | [
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] | [] | [] | [] |
DS.d1587 | 18845357 | [
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DS.d1595 | 18845639 | [
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DS.d1596 | 18845640 | [
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DS.d1600 | 18845662 | [
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DS.d1604 | 18845907 | [
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DS.d1605 | 18846314 | [
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DS.d1606 | 18846317 | [
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DS.d1612 | 18847329 | [
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DS.d1613 | 18847384 | [
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] | [] | [] | [] |
DS.d1615 | 18848532 | [
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DS.d1616 | 18848584 | [
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"type": "compound-protein-interaction",
"arg1_id": "DS.d1616.s0.e1",
"arg2_id": "DS.d1616.s0.e0",
"normalized": []
}
] |
DS.d1617 | 18848601 | [
{
"id": "DS.d1617.s0",
"type": "",
"text": [
"17beta-Hydroxysteroid dehydrogenase type 1 (17beta-HSD1) is responsible for the catalytic reduction of the weak estrogen estrone (E1) into the highly potent 17beta-estradiol (E2)."
],
"offsets": [
[
0,
179
]
]
}
] | [
{
"id": "DS.d1617.s0.e0",
"type": "protein",
"text": [
"17beta-Hydroxysteroid dehydrogenase type 1"
],
"offsets": [
[
0,
42
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "P14061"
},
{
"db_name": "UniProt",
"db_id": "P51656"
},
{
"db_name": "UniProt",
"db_id": "P51657"
},
{
"db_name": "UniProt",
"db_id": "Q1WNP0"
}
]
},
{
"id": "DS.d1617.s0.e1",
"type": "protein",
"text": [
"17beta-HSD1"
],
"offsets": [
[
44,
55
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "P14061"
},
{
"db_name": "UniProt",
"db_id": "P51656"
},
{
"db_name": "UniProt",
"db_id": "P51657"
},
{
"db_name": "UniProt",
"db_id": "Q1WNP0"
}
]
},
{
"id": "DS.d1617.s0.e3",
"type": "compound",
"text": [
"17beta-estradiol"
],
"offsets": [
[
157,
173
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "5757"
}
]
}
] | [] | [] | [
{
"id": "DS.d1617.s0.i1",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1617.s0.e3",
"arg2_id": "DS.d1617.s0.e0",
"normalized": []
},
{
"id": "DS.d1617.s0.i3",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1617.s0.e3",
"arg2_id": "DS.d1617.s0.e1",
"normalized": []
}
] |
DS.d1618 | 18848620 | [
{
"id": "DS.d1618.s0",
"type": "",
"text": [
"Blood was collected before and repeatedly afterward for determination of NF-kappaB activity, leukocyte subset numbers, cortisol, norepinephrine, and in vitro-stimulated IL-6 production."
],
"offsets": [
[
0,
185
]
]
},
{
"id": "DS.d1618.s1",
"type": "",
"text": [
"Higher NF-kappaB stress responses were associated with lower cortisol stress responses (beta=-.37, p=.05), higher pre-stress IL-6 production (beta=.38, p=.043), and high chronic in combination with low acute stress, or vice versa (beta=-.61, p=.06)."
],
"offsets": [
[
186,
435
]
]
}
] | [
{
"id": "DS.d1618.s0.e0",
"type": "compound",
"text": [
"cortisol"
],
"offsets": [
[
119,
127
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "5754"
}
]
},
{
"id": "DS.d1618.s0.e1",
"type": "compound",
"text": [
"norepinephrine"
],
"offsets": [
[
129,
143
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "951"
},
{
"db_name": "PubChem",
"db_id": "439260"
}
]
},
{
"id": "DS.d1618.s0.e2",
"type": "protein",
"text": [
"IL-6"
],
"offsets": [
[
169,
173
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "O35736"
},
{
"db_name": "UniProt",
"db_id": "P05231"
},
{
"db_name": "UniProt",
"db_id": "P08505"
},
{
"db_name": "UniProt",
"db_id": "P20607"
},
{
"db_name": "UniProt",
"db_id": "P26892"
},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
"db_id": "P29455"
},
{
"db_name": "UniProt",
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},
{
"db_name": "UniProt",
"db_id": "P41683"
},
{
"db_name": "UniProt",
"db_id": "P41693"
},
{
"db_name": "UniProt",
"db_id": "P46650"
},
{
"db_name": "UniProt",
"db_id": "P51494"
},
{
"db_name": "UniProt",
"db_id": "P79341"
},
{
"db_name": "UniProt",
"db_id": "Q25BC2"
},
{
"db_name": "UniProt",
"db_id": "Q28319"
},
{
"db_name": "UniProt",
"db_id": "Q28747"
},
{
"db_name": "UniProt",
"db_id": "Q28819"
},
{
"db_name": "UniProt",
"db_id": "Q2MH06"
},
{
"db_name": "UniProt",
"db_id": "Q5I6E3"
},
{
"db_name": "UniProt",
"db_id": "Q6V919"
},
{
"db_name": "UniProt",
"db_id": "Q865W7"
},
{
"db_name": "UniProt",
"db_id": "Q865X6"
},
{
"db_name": "UniProt",
"db_id": "Q8MKH0"
},
{
"db_name": "UniProt",
"db_id": "Q95181"
},
{
"db_name": "UniProt",
"db_id": "Q9MZR1"
},
{
"db_name": "UniProt",
"db_id": "Q9XT80"
}
]
},
{
"id": "DS.d1618.s1.e0",
"type": "compound",
"text": [
"cortisol"
],
"offsets": [
[
247,
255
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "5754"
}
]
},
{
"id": "DS.d1618.s1.e1",
"type": "protein",
"text": [
"IL-6"
],
"offsets": [
[
311,
315
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "O35736"
},
{
"db_name": "UniProt",
"db_id": "P05231"
},
{
"db_name": "UniProt",
"db_id": "P08505"
},
{
"db_name": "UniProt",
"db_id": "P20607"
},
{
"db_name": "UniProt",
"db_id": "P26892"
},
{
"db_name": "UniProt",
"db_id": "P26893"
},
{
"db_name": "UniProt",
"db_id": "P29455"
},
{
"db_name": "UniProt",
"db_id": "P41323"
},
{
"db_name": "UniProt",
"db_id": "P41683"
},
{
"db_name": "UniProt",
"db_id": "P41693"
},
{
"db_name": "UniProt",
"db_id": "P46650"
},
{
"db_name": "UniProt",
"db_id": "P51494"
},
{
"db_name": "UniProt",
"db_id": "P79341"
},
{
"db_name": "UniProt",
"db_id": "Q25BC2"
},
{
"db_name": "UniProt",
"db_id": "Q28319"
},
{
"db_name": "UniProt",
"db_id": "Q28747"
},
{
"db_name": "UniProt",
"db_id": "Q28819"
},
{
"db_name": "UniProt",
"db_id": "Q2MH06"
},
{
"db_name": "UniProt",
"db_id": "Q5I6E3"
},
{
"db_name": "UniProt",
"db_id": "Q6V919"
},
{
"db_name": "UniProt",
"db_id": "Q865W7"
},
{
"db_name": "UniProt",
"db_id": "Q865X6"
},
{
"db_name": "UniProt",
"db_id": "Q8MKH0"
},
{
"db_name": "UniProt",
"db_id": "Q95181"
},
{
"db_name": "UniProt",
"db_id": "Q9MZR1"
},
{
"db_name": "UniProt",
"db_id": "Q9XT80"
}
]
}
] | [] | [] | [] |
DS.d1620 | 18848646 | [
{
"id": "DS.d1620.s0",
"type": "",
"text": [
"The combination of leucine-rich repeat (LRR) and immunoglobulin-like (Ig) domains is found in the domain architecture of the Trk neurotrophin receptor protein."
],
"offsets": [
[
0,
159
]
]
},
{
"id": "DS.d1620.s1",
"type": "",
"text": [
"Given the significant biological roles of Trk and such newly identified proteins, we have searched the public database for human proteins with LRR and Ig domains (collectively termed the leucine-rich repeat and Ig domain-containing protein, LRRIG protein, in this study), and have analyzed the mRNA expression pattern of mouse orthologs of obtained human LRRIG proteins at embryonic day 10."
],
"offsets": [
[
160,
550
]
]
}
] | [
{
"id": "DS.d1620.s0.e0",
"type": "compound",
"text": [
"leucine"
],
"offsets": [
[
19,
26
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "857"
},
{
"db_name": "PubChem",
"db_id": "6106"
},
{
"db_name": "PubChem",
"db_id": "439524"
}
]
},
{
"id": "DS.d1620.s0.e1",
"type": "protein",
"text": [
"Trk"
],
"offsets": [
[
125,
128
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "P35739"
},
{
"db_name": "UniProt",
"db_id": "P47946"
},
{
"db_name": "UniProt",
"db_id": "Q24155"
}
]
},
{
"id": "DS.d1620.s1.e0",
"type": "protein",
"text": [
"Trk"
],
"offsets": [
[
202,
205
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "P35739"
},
{
"db_name": "UniProt",
"db_id": "P47946"
},
{
"db_name": "UniProt",
"db_id": "Q24155"
}
]
},
{
"id": "DS.d1620.s1.e1",
"type": "compound",
"text": [
"leucine"
],
"offsets": [
[
347,
354
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "857"
},
{
"db_name": "PubChem",
"db_id": "6106"
},
{
"db_name": "PubChem",
"db_id": "439524"
}
]
}
] | [] | [] | [
{
"id": "DS.d1620.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1620.s0.e0",
"arg2_id": "DS.d1620.s0.e1",
"normalized": []
}
] |
DS.d1621 | 18848727 | [
{
"id": "DS.d1621.s0",
"type": "",
"text": [
"Quantum chemical studies for oxidation of morpholine by Cytochrome P450."
],
"offsets": [
[
0,
72
]
]
},
{
"id": "DS.d1621.s1",
"type": "",
"text": [
"Since morpholine oxidation has recently been shown to involve Cytochrome P450, the study on its mechanism at molecular level using quantum chemical calculations for the model of cytochrome active site is reported here."
],
"offsets": [
[
73,
291
]
]
}
] | [
{
"id": "DS.d1621.s0.e0",
"type": "compound",
"text": [
"morpholine"
],
"offsets": [
[
42,
52
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "8083"
}
]
},
{
"id": "DS.d1621.s0.e1",
"type": "protein",
"text": [
"Cytochrome P450"
],
"offsets": [
[
56,
71
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "O08469"
}
]
},
{
"id": "DS.d1621.s1.e0",
"type": "compound",
"text": [
"morpholine"
],
"offsets": [
[
79,
89
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "8083"
}
]
},
{
"id": "DS.d1621.s1.e1",
"type": "protein",
"text": [
"Cytochrome P450"
],
"offsets": [
[
135,
150
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "O08469"
}
]
}
] | [] | [] | [
{
"id": "DS.d1621.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1621.s0.e0",
"arg2_id": "DS.d1621.s0.e1",
"normalized": []
},
{
"id": "DS.d1621.s1.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1621.s1.e0",
"arg2_id": "DS.d1621.s1.e1",
"normalized": []
}
] |
DS.d1622 | 18848748 | [
{
"id": "DS.d1622.s0",
"type": "",
"text": [
"Pretreatment with oligonol diminished the levels of proliferating cell nuclear antigen and expression of COX-2 in papillomas and carcinomas, respectively, as compared to DMBA plus TPA treatment alone."
],
"offsets": [
[
0,
200
]
]
}
] | [
{
"id": "DS.d1622.s0.e0",
"type": "protein",
"text": [
"proliferating cell nuclear antigen"
],
"offsets": [
[
52,
86
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "O01377"
},
{
"db_name": "UniProt",
"db_id": "O02115"
},
{
"db_name": "UniProt",
"db_id": "O16852"
},
{
"db_name": "UniProt",
"db_id": "O82134"
},
{
"db_name": "UniProt",
"db_id": "O82797"
},
{
"db_name": "UniProt",
"db_id": "P04961"
},
{
"db_name": "UniProt",
"db_id": "P12004"
},
{
"db_name": "UniProt",
"db_id": "P15873"
},
{
"db_name": "UniProt",
"db_id": "P17070"
},
{
"db_name": "UniProt",
"db_id": "P17917"
},
{
"db_name": "UniProt",
"db_id": "P17918"
},
{
"db_name": "UniProt",
"db_id": "P18248"
},
{
"db_name": "UniProt",
"db_id": "P22177"
},
{
"db_name": "UniProt",
"db_id": "P24314"
},
{
"db_name": "UniProt",
"db_id": "P31008"
},
{
"db_name": "UniProt",
"db_id": "P53358"
},
{
"db_name": "UniProt",
"db_id": "P57761"
},
{
"db_name": "UniProt",
"db_id": "P61074"
},
{
"db_name": "UniProt",
"db_id": "P61258"
},
{
"db_name": "UniProt",
"db_id": "Q00268"
},
{
"db_name": "UniProt",
"db_id": "Q03392"
},
{
"db_name": "UniProt",
"db_id": "Q43124"
},
{
"db_name": "UniProt",
"db_id": "Q43266"
},
{
"db_name": "UniProt",
"db_id": "Q6B6N4"
},
{
"db_name": "UniProt",
"db_id": "Q9DDF1"
},
{
"db_name": "UniProt",
"db_id": "Q9DEA3"
},
{
"db_name": "UniProt",
"db_id": "Q9MAY3"
},
{
"db_name": "UniProt",
"db_id": "Q9PTP1"
},
{
"db_name": "UniProt",
"db_id": "Q9W644"
}
]
},
{
"id": "DS.d1622.s0.e1",
"type": "protein",
"text": [
"COX-2"
],
"offsets": [
[
105,
110
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "O02768"
},
{
"db_name": "UniProt",
"db_id": "O19183"
},
{
"db_name": "UniProt",
"db_id": "O62698"
},
{
"db_name": "UniProt",
"db_id": "O62725"
},
{
"db_name": "UniProt",
"db_id": "P27607"
},
{
"db_name": "UniProt",
"db_id": "P35354"
},
{
"db_name": "UniProt",
"db_id": "P35355"
},
{
"db_name": "UniProt",
"db_id": "P70682"
},
{
"db_name": "UniProt",
"db_id": "P79208"
},
{
"db_name": "UniProt",
"db_id": "Q05769"
}
]
},
{
"id": "DS.d1622.s0.e2",
"type": "compound",
"text": [
"DMBA"
],
"offsets": [
[
170,
174
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "6001"
}
]
}
] | [] | [] | [
{
"id": "DS.d1622.s0.i0",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1622.s0.e2",
"arg2_id": "DS.d1622.s0.e1",
"normalized": []
},
{
"id": "DS.d1622.s0.i1",
"type": "compound-protein-interaction",
"arg1_id": "DS.d1622.s0.e2",
"arg2_id": "DS.d1622.s0.e0",
"normalized": []
}
] |
DS.d1623 | 18848782 | [
{
"id": "DS.d1623.s0",
"type": "",
"text": [
"TnBP (tri-n-butyl phosphate) and polysorbate 20 during the manufacture of the factor VIII/VWF concentrate Optivate has been investigated."
],
"offsets": [
[
0,
137
]
]
}
] | [
{
"id": "DS.d1623.s0.e0",
"type": "compound",
"text": [
"tri-n-butyl phosphate"
],
"offsets": [
[
6,
27
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "31357"
}
]
},
{
"id": "DS.d1623.s0.e1",
"type": "protein",
"text": [
"VWF"
],
"offsets": [
[
90,
93
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "P04275"
},
{
"db_name": "UniProt",
"db_id": "P80012"
},
{
"db_name": "UniProt",
"db_id": "Q28295"
},
{
"db_name": "UniProt",
"db_id": "Q28833"
},
{
"db_name": "UniProt",
"db_id": "Q8CIZ8"
}
]
}
] | [] | [] | [] |
DS.d1624 | 18848797 | [
{
"id": "DS.d1624.s0",
"type": "",
"text": [
"Euthyroid animals with a palpation score >or=3 were significantly older, had higher body weights, lower alkaline phosphatase, alanine aminotransferase, phosphate, and urine specific gravity, but higher lipase and creatinine concentrations than hyperthyroid cats."
],
"offsets": [
[
0,
265
]
]
}
] | [
{
"id": "DS.d1624.s0.e0",
"type": "protein",
"text": [
"alkaline phosphatase"
],
"offsets": [
[
107,
127
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "O60109"
},
{
"db_name": "UniProt",
"db_id": "P81800"
},
{
"db_name": "UniProt",
"db_id": "P83456"
}
]
},
{
"id": "DS.d1624.s0.e1",
"type": "compound",
"text": [
"phosphate"
],
"offsets": [
[
155,
164
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "1061"
},
{
"db_name": "PubChem",
"db_id": "167704"
},
{
"db_name": "PubChem",
"db_id": "644102"
}
]
},
{
"id": "DS.d1624.s0.e2",
"type": "protein",
"text": [
"lipase"
],
"offsets": [
[
205,
211
]
],
"normalized": [
{
"db_name": "UniProt",
"db_id": "Q7M4U7"
}
]
},
{
"id": "DS.d1624.s0.e3",
"type": "compound",
"text": [
"creatinine"
],
"offsets": [
[
216,
226
]
],
"normalized": [
{
"db_name": "PubChem",
"db_id": "588"
}
]
}
] | [] | [] | [] |
DS.d1625 | 18848818 | [
{
"id": "DS.d1625.s0",
"type": "",
"text": [
"A role for CB2 receptors in anandamide signalling pathways involved in the regulation of IL-12 and IL-23 in microglial cells."
],
"offsets": [
[
0,
125
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DS.d1628 | 18848894 | [
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DS.d1629 | 18848957 | [
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DS.d1630 | 18848961 | [
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DS.d1631 | 18848984 | [
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DS.d1632 | 18849028 | [
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DS.d1634 | 18849055 | [
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DS.d1636 | 18849110 | [
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DS.d1637 | 18849120 | [
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DS.d1638 | 18849121 | [
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DS.d1639 | 18849159 | [
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DS.d1640 | 18849171 | [
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DS.d1641 | 18849325 | [
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DS.d1642 | 18849352 | [
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] | [] | [] | [] |
DS.d1643 | 18849389 | [
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270,
389
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] | [
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] | [] | [] | [] |
DS.d1644 | 18849391 | [
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DS.d1645 | 18849413 | [
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DS.d1647 | 18849420 | [
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DS.d1648 | 18849565 | [
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DS.d1649 | 18849890 | [
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DS.d1650 | 18850007 | [
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DS.d1651 | 18850009 | [
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DS.d1652 | 18850074 | [
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DS.d1653 | 18850096 | [
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DS.d1654 | 18850241 | [
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DS.d1656 | 18850490 | [
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