Datasets:

bigbio

/

cpi

like 1

[ { "id": "DS.d1658.s0", "type": "", "text": [ "End-point measures were HOMA (homoeostasis model assessment)-IR, androgens, lipids, inflammatory markers (hsCRP (high-sensitivity C-reactive protein)) and endothelial function (FMD (flow-mediated dilation), ADMA (asymmetric dimethylarginine), PAI-1 (plasminogen activator inhibitor-1) and vWF (von Willebrand factor))." ], "offsets": [ [ 0, 318 ] ] } ]

[ { "id": "DS.d1658.s0.e0", "type": "compound", "text": [ "ADMA" ], "offsets": [ [ 207, 211 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123831" } ] }, { "id": "DS.d1658.s0.e1", "type": "compound", "text": [ "asymmetric dimethylarginine" ], "offsets": [ [ 213, 240 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123831" } ] }, { "id": "DS.d1658.s0.e2", "type": "protein", "text": [ "von Willebrand factor" ], "offsets": [ [ 294, 315 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q62935" } ] } ]

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[ { "id": "DS.d1659.s0", "type": "", "text": [ "Addition of SOD (superoxide dismutase) doubled the amount of HOBr detected." ], "offsets": [ [ 0, 75 ] ] } ]

[ { "id": "DS.d1659.s0.e0", "type": "protein", "text": [ "SOD" ], "offsets": [ [ 12, 15 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12933" }, { "db_name": "UniProt", "db_id": "O22668" }, { "db_name": "UniProt", "db_id": "O75007" }, { "db_name": "UniProt", "db_id": "P24705" }, { "db_name": "UniProt", "db_id": "P51547" }, { "db_name": "UniProt", "db_id": "P93258" }, { "db_name": "UniProt", "db_id": "Q01137" }, { "db_name": "UniProt", "db_id": "Q27666" }, { "db_name": "UniProt", "db_id": "Q9SM64" } ] }, { "id": "DS.d1659.s0.e1", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 17, 37 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] }, { "id": "DS.d1659.s0.e2", "type": "compound", "text": [ "HOBr" ], "offsets": [ [ 61, 65 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "83547" } ] } ]

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[ { "id": "DS.d1659.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1659.s0.e2", "arg2_id": "DS.d1659.s0.e1", "normalized": [] }, { "id": "DS.d1659.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1659.s0.e2", "arg2_id": "DS.d1659.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1660.s0", "type": "", "text": [ "Drug-resistant cancer cells became sensitive to doxorubicin treatment when nucleophosmin was expressed in cytosol." ], "offsets": [ [ 0, 114 ] ] } ]

[ { "id": "DS.d1660.s0.e0", "type": "compound", "text": [ "doxorubicin" ], "offsets": [ [ 48, 59 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "31703" } ] }, { "id": "DS.d1660.s0.e1", "type": "protein", "text": [ "nucleophosmin" ], "offsets": [ [ 75, 88 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06748" }, { "db_name": "UniProt", "db_id": "P07222" }, { "db_name": "UniProt", "db_id": "P13084" }, { "db_name": "UniProt", "db_id": "P16039" }, { "db_name": "UniProt", "db_id": "Q3T160" }, { "db_name": "UniProt", "db_id": "Q61937" } ] } ]

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[ { "id": "DS.d1660.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1660.s0.e0", "arg2_id": "DS.d1660.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1661.s0", "type": "", "text": [ "All the analyzed resistant mutants exhibited both increased econazole efflux and increased transcription of mmpS5-mmpL5 genes, encoding a hypothetical efflux system belonging to the resistance-nodulation-division (RND) family of transporters." ], "offsets": [ [ 0, 242 ] ] } ]

[ { "id": "DS.d1661.s0.e0", "type": "compound", "text": [ "econazole" ], "offsets": [ [ 60, 69 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3198" } ] }, { "id": "DS.d1661.s0.e1", "type": "protein", "text": [ "mmpS5" ], "offsets": [ [ 108, 113 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P65380" }, { "db_name": "UniProt", "db_id": "P65381" } ] }, { "id": "DS.d1661.s0.e2", "type": "protein", "text": [ "mmpL5" ], "offsets": [ [ 114, 119 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O53784" } ] } ]

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[ { "id": "DS.d1662.s0", "type": "", "text": [ "This study investigated the effects of atorvastatin on ABCB1 and ABCC1 mRNA expression on peripheral blood mononuclear cells (PBMC) and their relationship with gene polymorphisms and lowering-cholesterol response." ], "offsets": [ [ 0, 213 ] ] } ]

[ { "id": "DS.d1662.s0.e0", "type": "protein", "text": [ "ABCB1" ], "offsets": [ [ 55, 60 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08183" }, { "db_name": "UniProt", "db_id": "P21448" } ] }, { "id": "DS.d1662.s0.e1", "type": "protein", "text": [ "ABCC1" ], "offsets": [ [ 65, 70 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P33527" }, { "db_name": "UniProt", "db_id": "Q5F364" } ] }, { "id": "DS.d1662.s0.e2", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 192, 203 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]

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[ { "id": "DS.d1663.s0", "type": "", "text": [ "While the three SAT isotypes showed comparable Km and k(cat) for L-serine and acetyl-CoA, they showed remarkable differences in their sensitivity to inhibition by L-cysteine." ], "offsets": [ [ 0, 174 ] ] }, { "id": "DS.d1663.s1", "type": "", "text": [ "We propose that multiple SAT isotypes with different properties may play complementary roles in the regulation of the cysteine biosynthetic pathway in E. histolytica under different conditions, e.g." ], "offsets": [ [ 175, 373 ] ] } ]

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"db_name": "UniProt", "db_id": "Q9YCR4" }, { "db_name": "UniProt", "db_id": "Q9ZK14" } ] }, { "id": "DS.d1663.s1.e1", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 293, 301 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] } ]

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[ { "id": "DS.d1663.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1663.s0.e2", "arg2_id": "DS.d1663.s0.e0", "normalized": [] }, { "id": "DS.d1663.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1663.s0.e1", "arg2_id": "DS.d1663.s0.e0", "normalized": [] }, { "id": "DS.d1663.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1663.s1.e1", "arg2_id": "DS.d1663.s1.e0", "normalized": [] } ]

[ { "id": "DS.d1664.s0", "type": "", "text": [ "At 1 min before the exposure rats were treated with one of the following: intravenous aprotinin, 4.4 mg/kg; intraperitoneal (ip) ilomastat, 25mg/kg; or ip trolox, 500 microg/kg." ], "offsets": [ [ 0, 177 ] ] }, { "id": "DS.d1664.s1", "type": "", "text": [ "Treatment with aprotinin or ilomastat eliminated these PF changes, yielding results comparable with controls for each of these parameters." ], "offsets": [ [ 178, 316 ] ] }, { "id": "DS.d1664.s2", "type": "", "text": [ "While aprotinin and ilomastat both alleviated the PF perturbations, surprisingly only aprotinin reduced the observed pathology, both grossly and histologically." ], "offsets": [ [ 317, 477 ] ] }, { "id": "DS.d1664.s3", "type": "", "text": [ "These early results indicate that treatment with aprotinin and to a lesser extent ilomastat reduces some of the direct inflammatory response and damage associated with SM-induced lung injury." ], "offsets": [ [ 478, 669 ] ] } ]

[ { "id": "DS.d1664.s0.e0", "type": "protein", "text": [ "aprotinin" ], "offsets": [ [ 86, 95 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00974" } ] }, { "id": "DS.d1664.s0.e1", "type": "compound", "text": [ "ilomastat" ], "offsets": [ [ 129, 138 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "132519" } ] }, { "id": "DS.d1664.s0.e2", "type": "compound", "text": [ "trolox" ], "offsets": [ [ 155, 161 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "40634" } ] }, { "id": "DS.d1664.s1.e0", "type": "protein", "text": [ "aprotinin" ], "offsets": [ [ 193, 202 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00974" } ] }, { "id": "DS.d1664.s1.e1", "type": "compound", "text": [ "ilomastat" ], "offsets": [ [ 206, 215 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "132519" } ] }, { "id": "DS.d1664.s2.e0", "type": "protein", "text": [ "aprotinin" ], "offsets": [ [ 323, 332 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00974" } ] }, { "id": "DS.d1664.s2.e1", "type": "compound", "text": [ "ilomastat" ], "offsets": [ [ 337, 346 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "132519" } ] }, { "id": "DS.d1664.s2.e2", "type": "protein", "text": [ "aprotinin" ], "offsets": [ [ 403, 412 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00974" } ] }, { "id": "DS.d1664.s3.e0", "type": "protein", "text": [ "aprotinin" ], "offsets": [ [ 527, 536 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00974" } ] }, { "id": "DS.d1664.s3.e1", "type": "compound", "text": [ "ilomastat" ], "offsets": [ [ 560, 569 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "132519" } ] } ]

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[ { "id": "DS.d1666.s0", "type": "", "text": [ "Spermine oxidase (SMO) is a FAD-containing enzyme involved in animal cell polyamines (PA) homeostasis, selectively active on spermine and producing H(2)O(2), spermidine, and the 3-aminopropanal." ], "offsets": [ [ 0, 194 ] ] } ]

[ { "id": "DS.d1666.s0.e0", "type": "protein", "text": [ "Spermine oxidase" ], "offsets": [ [ 0, 16 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q99K82" }, { "db_name": "UniProt", "db_id": "Q9NWM0" } ] }, { "id": "DS.d1666.s0.e1", "type": "protein", "text": [ "SMO" ], "offsets": [ [ 18, 21 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42224" }, { "db_name": "UniProt", "db_id": "P56726" }, { "db_name": "UniProt", "db_id": "P97698" }, { "db_name": "UniProt", "db_id": "Q99835" }, { "db_name": "UniProt", "db_id": "Q9NWM0" } ] }, { "id": "DS.d1666.s0.e2", "type": "compound", "text": [ "spermine" ], "offsets": [ [ 125, 133 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1103" } ] } ]

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[ { "id": "DS.d1666.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1666.s0.e2", "arg2_id": "DS.d1666.s0.e1", "normalized": [] }, { "id": "DS.d1666.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1666.s0.e2", "arg2_id": "DS.d1666.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1667.s0", "type": "", "text": [ "Pretreatment with DEX abrogated calcitonin inhibition by sst (2)-preferring analogue octreotide in TT." ], "offsets": [ [ 0, 102 ] ] } ]

[ { "id": "DS.d1667.s0.e0", "type": "protein", "text": [ "calcitonin" ], "offsets": [ [ 32, 42 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01258" }, { "db_name": "UniProt", "db_id": "P01259" }, { "db_name": "UniProt", "db_id": "P01260" }, { "db_name": "UniProt", "db_id": "P01262" }, { "db_name": "UniProt", "db_id": "P0C234" } ] }, { "id": "DS.d1667.s0.e1", "type": "compound", "text": [ "octreotide" ], "offsets": [ [ 85, 95 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "383414" }, { "db_name": "PubChem", "db_id": "448601" } ] } ]

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[ { "id": "DS.d1667.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1667.s0.e1", "arg2_id": "DS.d1667.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1668.s0", "type": "", "text": [ "Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis." ], "offsets": [ [ 0, 121 ] ] } ]

[ { "id": "DS.d1668.s0.e0", "type": "compound", "text": [ "Leukotriene B4" ], "offsets": [ [ 0, 14 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280492" } ] }, { "id": "DS.d1668.s0.e1", "type": "protein", "text": [ "BLT1" ], "offsets": [ [ 78, 82 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q15722" } ] } ]

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[ { "id": "DS.d1668.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1668.s0.e0", "arg2_id": "DS.d1668.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1669.s0", "type": "", "text": [ "Semicarbazide-sensitive amine oxidase activity and total nitrite and nitrate concentrations in serum: novel biochemical markers for type 2 diabetes." ], "offsets": [ [ 0, 148 ] ] }, { "id": "DS.d1669.s1", "type": "", "text": [ "The aim of this study was to evaluate the activity of semicarbazide-sensitive amine oxidase (SSAO) and the total nitrite and nitrate (NO(x)) concentrations in serum from type 2 diabetic patients and control subjects in order to evaluate if they could be used as novel diabetic markers." ], "offsets": [ [ 149, 434 ] ] } ]

[ { "id": "DS.d1669.s0.e0", "type": "protein", "text": [ "Semicarbazide-sensitive amine oxidase" ], "offsets": [ [ 0, 37 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08590" }, { "db_name": "UniProt", "db_id": "O70423" }, { "db_name": "UniProt", "db_id": "Q16853" }, { "db_name": "UniProt", "db_id": "Q5R9I0" }, { "db_name": "UniProt", "db_id": "Q9TTK6" } ] }, { "id": "DS.d1669.s0.e1", "type": "compound", "text": [ "nitrate" ], "offsets": [ [ 69, 76 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "943" } ] }, { "id": "DS.d1669.s1.e0", "type": "protein", "text": [ "semicarbazide-sensitive amine oxidase" ], "offsets": [ [ 203, 240 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08590" }, { "db_name": "UniProt", "db_id": "O70423" }, { "db_name": "UniProt", "db_id": "Q16853" }, { "db_name": "UniProt", "db_id": "Q5R9I0" }, { "db_name": "UniProt", "db_id": "Q9TTK6" } ] }, { "id": "DS.d1669.s1.e1", "type": "protein", "text": [ "SSAO" ], "offsets": [ [ 242, 246 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08590" }, { "db_name": "UniProt", "db_id": "O70423" }, { "db_name": "UniProt", "db_id": "Q16853" }, { "db_name": "UniProt", "db_id": "Q5R9I0" }, { "db_name": "UniProt", "db_id": "Q9TTK6" } ] }, { "id": "DS.d1669.s1.e2", "type": "compound", "text": [ "nitrate" ], "offsets": [ [ 274, 281 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "943" } ] } ]

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[ { "id": "DS.d1670.s0", "type": "", "text": [ "Serum lipid, creatinine, uric acid, CRP, HbA(1C) and urinary albumin concentration were measured." ], "offsets": [ [ 0, 97 ] ] } ]

[ { "id": "DS.d1670.s0.e0", "type": "compound", "text": [ "creatinine" ], "offsets": [ [ 13, 23 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "588" } ] }, { "id": "DS.d1670.s0.e1", "type": "compound", "text": [ "uric acid" ], "offsets": [ [ 25, 34 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1175" } ] }, { "id": "DS.d1670.s0.e2", "type": "protein", "text": [ "CRP" ], "offsets": [ [ 36, 39 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19062" }, { "db_name": "UniProt", "db_id": "P02741" }, { "db_name": "UniProt", "db_id": "P02742" }, { "db_name": "UniProt", "db_id": "P08462" }, { "db_name": "UniProt", "db_id": "P18151" }, { "db_name": "UniProt", "db_id": "P21291" }, { "db_name": "UniProt", "db_id": "P41964" }, { "db_name": "UniProt", "db_id": "P47875" }, { "db_name": "UniProt", "db_id": "P49254" }, { "db_name": "UniProt", "db_id": "P49262" }, { "db_name": "UniProt", "db_id": "P52753" }, { "db_name": "UniProt", "db_id": "P67966" }, { "db_name": "UniProt", "db_id": "P67967" }, { "db_name": "UniProt", "db_id": "P97315" }, { "db_name": "UniProt", "db_id": "Q07203" } ] } ]

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[ { "id": "DS.d1671.s0", "type": "", "text": [ "Cryptolepine activity showed highest correlations to topoisomerase II and microtubule targeting drugs." ], "offsets": [ [ 0, 102 ] ] } ]

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[ { "id": "DS.d1672.s0", "type": "", "text": [ "Ulcerated tissues were processed to assess ulcer area, malondialdehyde, proliferating cell nuclear antigen (PCNA) and cleaved caspase-3." ], "offsets": [ [ 0, 136 ] ] } ]

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[ { "id": "DS.d1673.s0", "type": "", "text": [ "Serum NO, catalase and glutathione were measured." ], "offsets": [ [ 0, 49 ] ] }, { "id": "DS.d1673.s1", "type": "", "text": [ "Serum glutathione and catalase levels were significantly lower in FM patients than controls." ], "offsets": [ [ 50, 142 ] ] } ]

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}, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] }, { "id": "DS.d1673.s0.e1", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 23, 34 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d1673.s1.e0", "type": "compound", "text": [ "glutathione" ], "offsets": [ [ 56, 67 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d1673.s1.e1", "type": "protein", "text": [ "catalase" ], "offsets": [ [ 72, 80 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O24339" }, { "db_name": "UniProt", "db_id": "O52762" }, { "db_name": "UniProt", "db_id": "O62839" }, { "db_name": "UniProt", "db_id": "O68146" }, { "db_name": "UniProt", "db_id": "O77229" }, { "db_name": "UniProt", "db_id": "O93662" }, { "db_name": "UniProt", "db_id": "O97492" }, { "db_name": "UniProt", "db_id": "P00432" }, { "db_name": "UniProt", "db_id": "P04040" }, { 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"UniProt", "db_id": "P55310" }, { "db_name": "UniProt", "db_id": "P55311" }, { "db_name": "UniProt", "db_id": "P55313" }, { "db_name": "UniProt", "db_id": "P77872" }, { "db_name": "UniProt", "db_id": "P81138" }, { "db_name": "UniProt", "db_id": "P90682" }, { "db_name": "UniProt", "db_id": "Q27710" }, { "db_name": "UniProt", "db_id": "Q49XC1" }, { "db_name": "UniProt", "db_id": "Q4L643" }, { "db_name": "UniProt", "db_id": "Q59296" }, { "db_name": "UniProt", "db_id": "Q59337" }, { "db_name": "UniProt", "db_id": "Q59602" }, { "db_name": "UniProt", "db_id": "Q59714" }, { "db_name": "UniProt", "db_id": "Q5HG86" }, { "db_name": "UniProt", "db_id": "Q5HPK8" }, { "db_name": "UniProt", "db_id": "Q5RF10" }, { "db_name": "UniProt", "db_id": "Q64405" }, { "db_name": "UniProt", "db_id": "Q6G9M4" }, { "db_name": "UniProt", "db_id": "Q6GH72" }, { "db_name": "UniProt", "db_id": "Q7A5T2" }, { "db_name": "UniProt", "db_id": "Q8CPD0" }, { "db_name": "UniProt", "db_id": "Q8FWU0" }, { "db_name": "UniProt", "db_id": "Q8NWV5" }, { "db_name": "UniProt", "db_id": "Q8X1P0" }, { "db_name": "UniProt", "db_id": "Q8Y3P9" }, { "db_name": "UniProt", "db_id": "Q926X0" }, { "db_name": "UniProt", "db_id": "Q99UE2" }, { "db_name": "UniProt", "db_id": "Q9AXH0" }, { "db_name": "UniProt", "db_id": "Q9KW19" }, { "db_name": "UniProt", "db_id": "Q9L4S1" }, { "db_name": "UniProt", "db_id": "Q9M5L6" }, { "db_name": "UniProt", "db_id": "Q9PT92" }, { "db_name": "UniProt", "db_id": "Q9PWF7" }, { "db_name": "UniProt", "db_id": "Q9Z598" }, { "db_name": "UniProt", "db_id": "Q9ZKX5" }, { "db_name": "UniProt", "db_id": "Q9ZN99" } ] } ]

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[ { "id": "DS.d1674.s0", "type": "", "text": [ "This article discusses the physiology of proximal Na (+)/H(+) exchange, the multiple mechanisms of NHE3 regulation, and the reciprocal relationship between NHE3 and NHE8 at the lumen of the proximal tubule." ], "offsets": [ [ 0, 206 ] ] } ]

[ { "id": "DS.d1674.s0.e0", "type": "compound", "text": [ "Na" ], "offsets": [ [ 50, 52 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "923" }, { "db_name": "PubChem", "db_id": "373840" } ] }, { "id": "DS.d1674.s0.e1", "type": "protein", "text": [ "NHE3" ], "offsets": [ [ 99, 103 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P26432" }, { "db_name": "UniProt", "db_id": "P48764" }, { "db_name": "UniProt", "db_id": "Q28362" } ] }, { "id": "DS.d1674.s0.e2", "type": "protein", "text": [ "NHE3" ], "offsets": [ [ 156, 160 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P26432" }, { "db_name": "UniProt", "db_id": "P48764" }, { "db_name": "UniProt", "db_id": "Q28362" } ] }, { "id": "DS.d1674.s0.e3", "type": "protein", "text": [ "NHE8" ], "offsets": [ [ 165, 169 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9Y2E8" } ] } ]

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[ { "id": "DS.d1675.s0", "type": "", "text": [ "Cortisol and DHEA-sulfate response to rapid adrenocorticotropic hormone (ACTH) stimulation was inadequate." ], "offsets": [ [ 0, 106 ] ] } ]

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[ { "id": "DS.d1676.s0", "type": "", "text": [ "The effects of industrial storage on the changes of the cell viability and the activities of intracellular alcohol dehydrogenase (ADH) and glucose-6-phosphate dehydrogenase (G6PDH) in brewer's yeast, and the corresponding capacity for the bioconversion of ethyl-3-oxobutanoate (EOB) to ethyl (S)-3-hydroxybutanoate ((S)-EHB), were investigated." ], "offsets": [ [ 0, 344 ] ] }, { "id": "DS.d1676.s1", "type": "", "text": [ "The intracellular levels of ADH and G6PDH after permeabilization of these stored cells with cetyltrimetylammonium bromide (CTAB) were much higher, which showed only slight decrease within 2 weeks during the industrial storage." ], "offsets": [ [ 345, 571 ] ] } ]

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"db_id": "Q03384" }, { "db_name": "UniProt", "db_id": "Q05114" }, { "db_name": "UniProt", "db_id": "Q07588" }, { "db_name": "UniProt", "db_id": "Q09009" }, { "db_name": "UniProt", "db_id": "Q09010" }, { "db_name": "UniProt", "db_id": "Q24641" }, { "db_name": "UniProt", "db_id": "Q24803" }, { "db_name": "UniProt", "db_id": "Q27404" }, { "db_name": "UniProt", "db_id": "Q6LCE4" }, { "db_name": "UniProt", "db_id": "Q9GN94" }, { "db_name": "UniProt", "db_id": "Q9NAR7" }, { "db_name": "UniProt", "db_id": "Q9NG40" }, { "db_name": "UniProt", "db_id": "Q9NG42" }, { "db_name": "UniProt", "db_id": "Q9U8S9" } ] }, { "id": "DS.d1676.s0.e1", "type": "protein", "text": [ "ADH" ], "offsets": [ [ 130, 133 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06525" }, { "db_name": "UniProt", "db_id": "P0A9Q7" }, { "db_name": "UniProt", "db_id": "P0A9Q8" }, { "db_name": "UniProt", "db_id": "P17648" }, { "db_name": "UniProt", "db_id": "P33744" }, { "db_name": "UniProt", "db_id": "P42327" }, { "db_name": "UniProt", "db_id": "P48977" }, { "db_name": "UniProt", "db_id": "P81786" }, { "db_name": "UniProt", "db_id": "Q04983" }, { "db_name": "UniProt", "db_id": "Q24803" }, { "db_name": "UniProt", "db_id": "Q24857" }, { "db_name": "UniProt", "db_id": "Q9NAR7" } ] }, { "id": "DS.d1676.s0.e2", "type": "protein", "text": [ "G6PDH" ], "offsets": [ [ 174, 179 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P37830" }, { "db_name": "UniProt", "db_id": "P48826" } ] }, { "id": "DS.d1676.s0.e3", "type": "compound", "text": [ "ethyl-3-oxobutanoate" ], "offsets": [ [ 256, 276 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "8868" } ] }, { "id": "DS.d1676.s0.e4", "type": "compound", "text": [ "EOB" ], "offsets": [ [ 278, 281 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9547937" } ] }, { "id": "DS.d1676.s0.e5", "type": "compound", "text": [ "S)-3-hydroxybutanoate" ], "offsets": [ [ 293, 314 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "94318" } ] }, { "id": "DS.d1676.s0.e6", "type": "compound", "text": [ "EHB" ], "offsets": [ [ 320, 323 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "46942358" } ] }, { "id": "DS.d1676.s1.e0", "type": "protein", "text": [ "ADH" ], "offsets": [ [ 373, 376 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06525" }, { "db_name": "UniProt", "db_id": "P0A9Q7" }, { "db_name": "UniProt", "db_id": "P0A9Q8" }, { "db_name": "UniProt", "db_id": "P17648" }, { "db_name": "UniProt", "db_id": "P33744" }, { "db_name": "UniProt", "db_id": "P42327" }, { "db_name": "UniProt", "db_id": "P48977" }, { "db_name": "UniProt", "db_id": "P81786" }, { "db_name": "UniProt", "db_id": "Q04983" }, { "db_name": "UniProt", "db_id": "Q24803" }, { "db_name": "UniProt", "db_id": "Q24857" }, { "db_name": "UniProt", "db_id": "Q9NAR7" } ] }, { "id": "DS.d1676.s1.e1", "type": "protein", "text": [ "G6PDH" ], "offsets": [ [ 381, 386 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P37830" }, { "db_name": "UniProt", "db_id": "P48826" } ] }, { "id": "DS.d1676.s1.e2", "type": "compound", "text": [ "CTAB" ], "offsets": [ [ 468, 472 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2681" } ] } ]

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[ { "id": "DS.d1677.s0", "type": "", "text": [ "Streptokinase (SK), glucose oxidase (GOx) and phosphorylcholine (PC) were immobilized onto PGLD to obtain a blood compatible bioconjugate with glucose sensing properties." ], "offsets": [ [ 0, 170 ] ] } ]

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[ { "id": "DS.d1678.s0", "type": "", "text": [ "Treatment of RPE cells with high glucose-induced a significant increased of iNOS, accompanied by an increase in cell damage, NO and nitrotyrosine levels." ], "offsets": [ [ 0, 153 ] ] }, { "id": "DS.d1678.s1", "type": "", "text": [ "High glucose causes increased cell damage and NO generation in RPE cells by a process of iNOS expression that requires the activation of p38MAPK and ERK." ], "offsets": [ [ 154, 307 ] ] } ]

[ { "id": "DS.d1678.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 33, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "64689" } ] }, { "id": "DS.d1678.s0.e1", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 76, 80 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d1678.s1.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 159, 166 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "64689" } ] }, { "id": "DS.d1678.s1.e1", "type": "protein", "text": [ "iNOS" ], "offsets": [ [ 243, 247 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O19114" }, { "db_name": "UniProt", "db_id": "O46660" }, { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O62699" }, { "db_name": "UniProt", "db_id": "P29477" }, { "db_name": "UniProt", "db_id": "P35228" }, { "db_name": "UniProt", "db_id": "P79290" }, { "db_name": "UniProt", "db_id": "Q06518" }, { "db_name": "UniProt", "db_id": "Q27995" }, { "db_name": "UniProt", "db_id": "Q28314" }, { "db_name": "UniProt", "db_id": "Q90703" }, { "db_name": "UniProt", "db_id": "Q92037" }, { "db_name": "UniProt", "db_id": "Q92091" } ] }, { "id": "DS.d1678.s1.e2", "type": "protein", "text": [ "p38MAPK" ], "offsets": [ [ 291, 298 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O62618" } ] }, { "id": "DS.d1678.s1.e3", "type": "protein", "text": [ "ERK" ], "offsets": [ [ 303, 306 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P29323" } ] } ]

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[ { "id": "DS.d1678.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1678.s0.e0", "arg2_id": "DS.d1678.s0.e1", "normalized": [] }, { "id": "DS.d1678.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1678.s1.e0", "arg2_id": "DS.d1678.s1.e1", "normalized": [] } ]

[ { "id": "DS.d1679.s0", "type": "", "text": [ "A crude peel extract and purified fraction of Flemingia vestita, as well as a crude rhizome extract of Stephania glabra and fractions were tested with respect to the activity of NOS, NO efflux and cGMP concentration in the cestode Raillietina echinobothrida in order to find out the possible mode of anthelmintic action of these plant-derived components." ], "offsets": [ [ 0, 354 ] ] } ]

[ { "id": "DS.d1679.s0.e0", "type": "protein", "text": [ "NOS" ], "offsets": [ [ 178, 181 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O54705" }, { "db_name": "UniProt", "db_id": "O61309" }, { "db_name": "UniProt", "db_id": "O61608" }, { "db_name": "UniProt", "db_id": "Q26240" }, { "db_name": "UniProt", "db_id": "Q28969" }, { "db_name": "UniProt", "db_id": "Q9I9M2" } ] }, { "id": "DS.d1679.s0.e1", "type": "compound", "text": [ "cGMP" ], "offsets": [ [ 197, 201 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24316" } ] } ]

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[ { "id": "DS.d1680.s0", "type": "", "text": [ "Our data suggest that PKCalpha translocates to the contractile system and anchors to TnI in a Ca(2+)-dependent manner in the human heart, contributing to the maintenance of contractile force." ], "offsets": [ [ 0, 191 ] ] } ]

[ { "id": "DS.d1680.s0.e0", "type": "protein", "text": [ "PKCalpha" ], "offsets": [ [ 22, 30 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04409" }, { "db_name": "UniProt", "db_id": "P05696" }, { "db_name": "UniProt", "db_id": "P10102" }, { "db_name": "UniProt", "db_id": "P17252" }, { "db_name": "UniProt", "db_id": "P20444" } ] }, { "id": "DS.d1680.s0.e1", "type": "protein", "text": [ "TnI" ], "offsets": [ [ 85, 88 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05547" }, { "db_name": "UniProt", "db_id": "P36188" }, { "db_name": "UniProt", "db_id": "Q7M3Y3" } ] }, { "id": "DS.d1680.s0.e2", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 94, 98 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] } ]

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[ { "id": "DS.d1680.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1680.s0.e2", "arg2_id": "DS.d1680.s0.e0", "normalized": [] }, { "id": "DS.d1680.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1680.s0.e2", "arg2_id": "DS.d1680.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1681.s0", "type": "", "text": [ "In this study, we describe the crystal structure of yeast PNGase in complex with N,N'-diacetylchitobiose (chitobiose)." ], "offsets": [ [ 0, 118 ] ] }, { "id": "DS.d1681.s1", "type": "", "text": [ "Mutagenesis studies confirm the critical role of the chitobiose-interacting residues in substrate binding and suggest that efficient oligosaccharide binding is required for PNGase activity." ], "offsets": [ [ 119, 308 ] ] } ]

[ { "id": "DS.d1681.s0.e0", "type": "protein", "text": [ "PNGase" ], "offsets": [ [ 58, 64 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O74739" }, { "db_name": "UniProt", "db_id": "Q02890" }, { "db_name": "UniProt", "db_id": "Q4R6F3" }, { "db_name": "UniProt", "db_id": "Q503I8" }, { "db_name": "UniProt", "db_id": "Q59Q38" }, { "db_name": "UniProt", "db_id": "Q5XI55" }, { "db_name": "UniProt", "db_id": "Q5ZJM3" }, { "db_name": "UniProt", "db_id": "Q6BNI6" }, { "db_name": "UniProt", "db_id": "Q6CAX5" }, { "db_name": "UniProt", "db_id": "Q6CLZ6" }, { "db_name": "UniProt", "db_id": "Q6FRU8" }, { "db_name": "UniProt", "db_id": "Q75D29" }, { "db_name": "UniProt", "db_id": "Q7KRR5" }, { "db_name": "UniProt", "db_id": "Q96IV0" }, { "db_name": "UniProt", "db_id": "Q9JI78" } ] }, { "id": "DS.d1681.s0.e1", "type": "compound", "text": [ "N,N'-diacetylchitobiose" ], "offsets": [ [ 81, 104 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439544" } ] }, { "id": "DS.d1681.s1.e0", "type": "compound", "text": [ "chitobiose" ], "offsets": [ [ 172, 182 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439544" } ] }, { "id": "DS.d1681.s1.e1", "type": "protein", "text": [ "PNGase" ], "offsets": [ [ 292, 298 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O74739" }, { "db_name": "UniProt", "db_id": "Q02890" }, { "db_name": "UniProt", "db_id": "Q4R6F3" }, { "db_name": "UniProt", "db_id": "Q503I8" }, { "db_name": "UniProt", "db_id": "Q59Q38" }, { "db_name": "UniProt", "db_id": "Q5XI55" }, { "db_name": "UniProt", "db_id": "Q5ZJM3" }, { "db_name": "UniProt", "db_id": "Q6BNI6" }, { "db_name": "UniProt", "db_id": "Q6CAX5" }, { "db_name": "UniProt", "db_id": "Q6CLZ6" }, { "db_name": "UniProt", "db_id": "Q6FRU8" }, { "db_name": "UniProt", "db_id": "Q75D29" }, { "db_name": "UniProt", "db_id": "Q7KRR5" }, { "db_name": "UniProt", "db_id": "Q96IV0" }, { "db_name": "UniProt", "db_id": "Q9JI78" } ] } ]

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[ { "id": "DS.d1681.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1681.s0.e1", "arg2_id": "DS.d1681.s0.e0", "normalized": [] }, { "id": "DS.d1681.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1681.s1.e0", "arg2_id": "DS.d1681.s1.e1", "normalized": [] } ]

[ { "id": "DS.d1682.s0", "type": "", "text": [ "Prediction of the effect of erythromycin, diltiazem, and their metabolites, alone and in combination, on CYP3A4 inhibition." ], "offsets": [ [ 0, 123 ] ] } ]

[ { "id": "DS.d1682.s0.e0", "type": "compound", "text": [ "erythromycin" ], "offsets": [ [ 28, 40 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "12560" } ] }, { "id": "DS.d1682.s0.e1", "type": "compound", "text": [ "diltiazem" ], "offsets": [ [ 42, 51 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "39186" } ] }, { "id": "DS.d1682.s0.e2", "type": "protein", "text": [ "CYP3A4" ], "offsets": [ [ 105, 111 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P08684" } ] } ]

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[ { "id": "DS.d1683.s0", "type": "", "text": [ "Previous studies have suggested a regulatory relationship between serum phosphorus, vitamin D, and fibroblast growth factor 23 (FGF23), a hormone that promotes renal excretion of phosphate." ], "offsets": [ [ 0, 189 ] ] }, { "id": "DS.d1683.s1", "type": "", "text": [ "This condition is caused by mutations in the PTH/PTHrP receptor that result in ligand-independent cAMP accumulation, thus rendering the receptor constitutively active." ], "offsets": [ [ 190, 357 ] ] } ]

[ { "id": "DS.d1683.s0.e0", "type": "compound", "text": [ "phosphorus" ], "offsets": [ [ 72, 82 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24404" }, { "db_name": "PubChem", "db_id": "139579" } ] }, { "id": "DS.d1683.s0.e1", "type": "compound", "text": [ "vitamin D" ], "offsets": [ [ 84, 93 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5280795" } ] }, { "id": "DS.d1683.s0.e2", "type": "protein", "text": [ "FGF23" ], "offsets": [ [ 128, 133 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q5MK86" }, { "db_name": "UniProt", "db_id": "Q9GZV9" } ] }, { "id": "DS.d1683.s1.e0", "type": "protein", "text": [ "PTH" ], "offsets": [ [ 235, 238 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O27732" }, { "db_name": "UniProt", "db_id": "O28185" }, { "db_name": "UniProt", "db_id": "O66677" }, { "db_name": "UniProt", "db_id": "O74017" }, { "db_name": "UniProt", "db_id": "O74806" }, { "db_name": "UniProt", "db_id": "O83975" }, { "db_name": "UniProt", "db_id": "O84806" 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[ { "id": "DS.d1688.s0", "type": "", "text": [ "In addition, SAH caused large increases in markers of inflammation, including TNFalpha and NFkappaB, and markers of cell injury or cell death, including IgG endocytosis and caspase-3 activation, with glibenclamide significantly reducing these effects." ], "offsets": [ [ 0, 251 ] ] }, { "id": "DS.d1688.s1", "type": "", "text": [ "We conclude that block of SUR1 by glibenclamide may ameliorate several pathologic effects associated with inflammation that lead to cortical dysfunction after SAH." ], "offsets": [ [ 252, 415 ] ] } ]

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[ { "id": "DS.d1689.s0", "type": "", "text": [ "Intrinsic fluorescence of tryptophan-214 in HSA was monitored upon addition of the chemicals." ], "offsets": [ [ 0, 93 ] ] } ]

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[ { "id": "DS.d1690.s0", "type": "", "text": [ "The COMT enzyme breaks down extracellular dopamine (DA) and has a particularly important role in the prefrontal cortex (PFC) where DA transporters are sparse." ], "offsets": [ [ 0, 158 ] ] } ]

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[ { "id": "DS.d1692.s0", "type": "", "text": [ "CYP719A subfamily of cytochrome P450 oxygenases and isoquinoline alkaloid biosynthesis in Eschscholzia californica." ], "offsets": [ [ 0, 115 ] ] } ]

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[]

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[ { "id": "DS.d1693.s0", "type": "", "text": [ "The metal-thiolate connectivity of recombinant Cd(7)-MT10 metallothionein from the sea mussel Mytilus galloprovincialis has been investigated for the first time by means of multinuclear, multidimensional NMR spectroscopy." ], "offsets": [ [ 0, 221 ] ] } ]

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[ { "id": "DS.d1694.s0", "type": "", "text": [ "Radical scavenging activity of lipophilized products from lipase-catalyzed transesterification of triolein with cinnamic and ferulic acids." ], "offsets": [ [ 0, 139 ] ] }, { "id": "DS.d1694.s1", "type": "", "text": [ "Lipase-catalyzed transesterification of triolein with cinnamic and ferulic acids using an immobilized lipase from Candida antarctica (E.C." ], "offsets": [ [ 140, 278 ] ] } ]

[ { "id": "DS.d1694.s0.e0", "type": "protein", "text": [ "lipase" ], "offsets": [ [ 58, 64 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] }, { "id": "DS.d1694.s0.e1", "type": "compound", "text": [ "triolein" ], "offsets": [ [ 98, 106 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5497163" } ] }, { "id": "DS.d1694.s1.e0", "type": "protein", "text": [ "Lipase" ], "offsets": [ [ 140, 146 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] }, { "id": "DS.d1694.s1.e1", "type": "compound", "text": [ "triolein" ], "offsets": [ [ 180, 188 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5497163" } ] }, { "id": "DS.d1694.s1.e2", "type": "protein", "text": [ "lipase" ], "offsets": [ [ 242, 248 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q7M4U7" } ] } ]

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[ { "id": "DS.d1694.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1694.s0.e1", "arg2_id": "DS.d1694.s0.e0", "normalized": [] }, { "id": "DS.d1694.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1694.s1.e1", "arg2_id": "DS.d1694.s1.e2", "normalized": [] }, { "id": "DS.d1694.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1694.s1.e1", "arg2_id": "DS.d1694.s1.e0", "normalized": [] } ]

[ { "id": "DS.d1695.s0", "type": "", "text": [ "Validation of a food frequency questionnaire measurement of dietary acrylamide intake using hemoglobin adducts of acrylamide and glycidamide." ], "offsets": [ [ 0, 141 ] ] } ]

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[ { "id": "DS.d1696.s0", "type": "", "text": [ "Effects of weight loss on visceral and abdominal subcutaneous adipose tissue blood-flow and insulin-mediated glucose uptake in healthy obese subjects." ], "offsets": [ [ 0, 150 ] ] } ]

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[ { "id": "DS.d1697.s0", "type": "", "text": [ "The study established that SPZ attenuated myocardial I/R injury through overexpression of iNOS, leading to enhancement of nitric oxide bioavailability and tissue oxygenation." ], "offsets": [ [ 0, 174 ] ] } ]

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[ { "id": "DS.d1698.s0", "type": "", "text": [ "Currently, pyridoxal-5'-phosphate (PLP)-dependent cystathionine beta-synthase (CBS) is thought to be the major H(2)S-producing enzyme in the brain." ], "offsets": [ [ 0, 147 ] ] } ]

[ { "id": "DS.d1698.s0.e0", "type": "compound", "text": [ "pyridoxal-5'-phosphate" ], "offsets": [ [ 11, 33 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1051" } ] }, { "id": "DS.d1698.s0.e1", "type": "protein", "text": [ "cystathionine beta-synthase" ], "offsets": [ [ 50, 77 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P32232" }, { "db_name": "UniProt", "db_id": "P32582" }, { "db_name": "UniProt", "db_id": "P35520" }, { "db_name": "UniProt", "db_id": "P46794" }, { "db_name": "UniProt", "db_id": "Q58H57" }, { "db_name": "UniProt", "db_id": "Q91WT9" }, { "db_name": "UniProt", "db_id": "Q9N0V7" }, { "db_name": "UniProt", "db_id": "Q9YBL2" } ] } ]

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[ { "id": "DS.d1698.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1698.s0.e0", "arg2_id": "DS.d1698.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1700.s1", "type": "", "text": [ "The purpose of this study was to propose a new preparation method to fabricate insulin-loaded poly(lactic-coglycolic acid) (PLGA) microparticles satisfying protein loading, release profiles, burst release, and particularly stability of the encapsulated protein." ], "offsets": [ [ 0, 261 ] ] } ]

[ { "id": "DS.d1700.s1.e0", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 79, 86 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1700.s1.e1", "type": "compound", "text": [ "PLGA" ], "offsets": [ [ 124, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "36797" } ] } ]

[]

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[ { "id": "DS.d1700.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1700.s1.e1", "arg2_id": "DS.d1700.s1.e0", "normalized": [] } ]

[ { "id": "DS.d1702.s0", "type": "", "text": [ "This injury induces central sensitization leading to tactile allodynia and is mediated by activation of Ca(2+) permeable AMPA/kainate receptors through PKC and PKA." ], "offsets": [ [ 0, 164 ] ] } ]

[ { "id": "DS.d1702.s0.e0", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 104, 108 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d1702.s0.e1", "type": "protein", "text": [ "PKC" ], "offsets": [ [ 152, 155 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P05130" }, { "db_name": "UniProt", "db_id": "P13677" }, { "db_name": "UniProt", "db_id": "P13678" }, { "db_name": "UniProt", "db_id": "P34722" } ] } ]

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[ { "id": "DS.d1702.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1702.s0.e0", "arg2_id": "DS.d1702.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1703.s0", "type": "", "text": [ "Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand." ], "offsets": [ [ 0, 88 ] ] } ]

[ { "id": "DS.d1703.s0.e0", "type": "protein", "text": [ "acetyltransferase" ], "offsets": [ [ 23, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16966" } ] }, { "id": "DS.d1703.s0.e1", "type": "compound", "text": [ "C3d" ], "offsets": [ [ 44, 47 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "216416" } ] } ]

[]

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[ { "id": "DS.d1703.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1703.s0.e1", "arg2_id": "DS.d1703.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1704.s0", "type": "", "text": [ "Transport properties of PIs by the drug efflux transporters P-gp and multidrug resistance protein 1 (MRP1) were assessed by measuring the cellular uptake of (3)H-atazanavir or (3)H-ritonavir in P-gp and MRP1 overexpressing cells as well as hCMEC/D3." ], "offsets": [ [ 0, 249 ] ] } ]

[ { "id": "DS.d1704.s0.e0", "type": "protein", "text": [ "multidrug resistance protein 1" ], "offsets": [ [ 69, 99 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06795" }, { "db_name": "UniProt", "db_id": "P08183" }, { "db_name": "UniProt", "db_id": "P16875" }, { "db_name": "UniProt", "db_id": "P21448" }, { "db_name": "UniProt", "db_id": "P33449" }, { "db_name": "UniProt", "db_id": "P34712" }, { "db_name": "UniProt", "db_id": "P43245" }, { "db_name": "UniProt", "db_id": "Q06034" }, { "db_name": "UniProt", "db_id": "Q9ZR72" } ] }, { "id": "DS.d1704.s0.e1", "type": "compound", "text": [ "atazanavir" ], "offsets": [ [ 162, 172 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "148192" } ] }, { "id": "DS.d1704.s0.e2", "type": "compound", "text": [ "ritonavir" ], "offsets": [ [ 181, 190 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "392622" } ] } ]

[]

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[ { "id": "DS.d1704.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1704.s0.e1", "arg2_id": "DS.d1704.s0.e0", "normalized": [] }, { "id": "DS.d1704.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1704.s0.e2", "arg2_id": "DS.d1704.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1705.s0", "type": "", "text": [ "Incubation of L6 myotubes with palmitate (for 16 h) increases intramyocellular ceramide and reduces insulin-stimulated PKB activation and glucose uptake." ], "offsets": [ [ 0, 153 ] ] } ]

[ { "id": "DS.d1705.s0.e0", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 100, 107 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1705.s0.e1", "type": "protein", "text": [ "PKB" ], "offsets": [ [ 119, 122 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31749" }, { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "P47196" }, { "db_name": "UniProt", "db_id": "Q01314" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] }, { "id": "DS.d1705.s0.e2", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 138, 145 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] } ]

[]

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[ { "id": "DS.d1706.s0", "type": "", "text": [ "This is the first cyclodextrin glycosyltransferase with a known primary structure and a glutamine instead of glycine residue at position 179 in the highly conserved-6 subsite, shown to be involved in substrate binding." ], "offsets": [ [ 0, 218 ] ] } ]

[ { "id": "DS.d1706.s0.e0", "type": "protein", "text": [ "cyclodextrin glycosyltransferase" ], "offsets": [ [ 18, 50 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O30565" }, { "db_name": "UniProt", "db_id": "P04830" }, { "db_name": "UniProt", "db_id": "P05618" }, { "db_name": "UniProt", "db_id": "P08704" }, { "db_name": "UniProt", "db_id": "P09121" }, { "db_name": "UniProt", "db_id": "P14014" }, { "db_name": "UniProt", "db_id": "P17692" }, { "db_name": "UniProt", "db_id": "P26827" }, { "db_name": "UniProt", "db_id": "P27036" }, { "db_name": "UniProt", "db_id": "P30920" }, { "db_name": "UniProt", "db_id": "P30921" }, { "db_name": "UniProt", "db_id": "P31746" }, { "db_name": "UniProt", "db_id": "P31747" }, { "db_name": "UniProt", "db_id": "P31797" }, { "db_name": "UniProt", "db_id": "P31835" }, { "db_name": "UniProt", "db_id": "P43379" } ] }, { "id": "DS.d1706.s0.e1", "type": "compound", "text": [ "glutamine" ], "offsets": [ [ 88, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "738" }, { "db_name": "PubChem", "db_id": "5961" } ] }, { "id": "DS.d1706.s0.e2", "type": "compound", "text": [ "glycine" ], "offsets": [ [ 109, 116 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "750" } ] } ]

[]

[]

[ { "id": "DS.d1706.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1706.s0.e2", "arg2_id": "DS.d1706.s0.e0", "normalized": [] }, { "id": "DS.d1706.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1706.s0.e1", "arg2_id": "DS.d1706.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1707.s0", "type": "", "text": [ "Functional LCAT is not required for macrophage cholesterol efflux to human serum." ], "offsets": [ [ 0, 81 ] ] } ]

[ { "id": "DS.d1707.s0.e0", "type": "protein", "text": [ "LCAT" ], "offsets": [ [ 11, 15 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O35502" }, { "db_name": "UniProt", "db_id": "O35573" }, { "db_name": "UniProt", "db_id": "O35724" }, { "db_name": "UniProt", "db_id": "O35840" }, { "db_name": "UniProt", "db_id": "P04180" }, { "db_name": "UniProt", "db_id": "P30930" }, { "db_name": "UniProt", "db_id": "P53760" }, { "db_name": "UniProt", "db_id": "P53761" }, { "db_name": "UniProt", "db_id": "Q08758" } ] }, { "id": "DS.d1707.s0.e1", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 47, 58 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]

[]

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[ { "id": "DS.d1708.s0", "type": "", "text": [ "The AbfR/S two-component system is required to activate the expression of the suite of enzymes that remove the numerous side chains from xylan, but not the xylanases that hydrolyze the beta1,4-linked xylose polymeric backbone of this polysaccharide." ], "offsets": [ [ 0, 249 ] ] } ]

[ { "id": "DS.d1708.s0.e0", "type": "compound", "text": [ "xylan" ], "offsets": [ [ 137, 142 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "50909243" } ] }, { "id": "DS.d1708.s0.e1", "type": "protein", "text": [ "xylanases" ], "offsets": [ [ 156, 165 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O43097" }, { "db_name": "UniProt", "db_id": "O59859" }, { "db_name": "UniProt", "db_id": "O60206" }, { "db_name": "UniProt", "db_id": "P07529" }, { "db_name": "UniProt", "db_id": "P09850" }, { "db_name": "UniProt", "db_id": "P17137" }, { "db_name": "UniProt", "db_id": "P23360" }, { "db_name": "UniProt", "db_id": "P23557" }, { "db_name": "UniProt", "db_id": "P29417" }, { "db_name": "UniProt", "db_id": "P40943" }, { "db_name": "UniProt", "db_id": "P45703" }, { "db_name": "UniProt", "db_id": "P48793" }, { "db_name": "UniProt", "db_id": "P56588" }, { "db_name": "UniProt", "db_id": "P81536" }, { "db_name": "UniProt", "db_id": "Q53317" } ] } ]

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[ { "id": "DS.d1709.s0", "type": "", "text": [ "In agreement with molecular modeling predictions, the inhibitory action of pPTME and PTME toward intracellular ODC of LN229 cells exceeded that of the previous designed lead compound POB." ], "offsets": [ [ 0, 187 ] ] } ]

[ { "id": "DS.d1709.s0.e0", "type": "protein", "text": [ "ODC" ], "offsets": [ [ 111, 114 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O22616" }, { "db_name": "UniProt", "db_id": "P00860" }, { "db_name": "UniProt", "db_id": "P07805" }, { "db_name": "UniProt", "db_id": "P08432" }, { "db_name": "UniProt", "db_id": "P09057" }, { "db_name": "UniProt", "db_id": "P11926" }, { "db_name": "UniProt", "db_id": "P14019" }, { "db_name": "UniProt", "db_id": "P27116" }, { "db_name": "UniProt", "db_id": "P27117" }, { "db_name": "UniProt", "db_id": "P27118" }, { "db_name": "UniProt", "db_id": "P27119" }, { "db_name": "UniProt", "db_id": "P27121" }, { "db_name": "UniProt", "db_id": "P40807" }, { "db_name": "UniProt", "db_id": "P40808" }, { "db_name": "UniProt", "db_id": "P41931" }, { "db_name": "UniProt", "db_id": "P43099" }, { "db_name": "UniProt", "db_id": "P49725" }, { "db_name": "UniProt", "db_id": "P50134" }, { "db_name": "UniProt", "db_id": "P78599" }, { "db_name": "UniProt", "db_id": "Q5RFB7" }, { "db_name": "UniProt", "db_id": "Q8S3N2" }, { "db_name": "UniProt", "db_id": "Q92445" }, { "db_name": "UniProt", "db_id": "Q9BQT8" }, { "db_name": "UniProt", "db_id": "Q9UQW9" } ] }, { "id": "DS.d1709.s0.e1", "type": "compound", "text": [ "POB" ], "offsets": [ [ 183, 186 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9543438" } ] } ]

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[ { "id": "DS.d1709.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1709.s0.e1", "arg2_id": "DS.d1709.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1710.s0", "type": "", "text": [ "Treatment with acidified saline reduced fetal basal pH from 7.35+/-0.01 to 7.29+/-0.01 but did not alter basal cardiovascular variables, blood glucose, or plasma concentrations of catecholamines, ACTH, and cortisol." ], "offsets": [ [ 0, 215 ] ] }, { "id": "DS.d1710.s1", "type": "", "text": [ "During hypoxemia, treatment with acidified saline increased the magnitude of the fetal bradycardia and femoral vasoconstriction and concomitantly increased chemoreflex function and enhanced the increments in plasma concentrations of catecholamines, ACTH, and cortisol." ], "offsets": [ [ 216, 484 ] ] } ]

[ { "id": "DS.d1710.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 143, 150 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1710.s0.e1", "type": "protein", "text": [ "ACTH" ], "offsets": [ [ 196, 200 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01189" }, { "db_name": "UniProt", "db_id": "P01190" }, { "db_name": "UniProt", "db_id": "P01191" }, { "db_name": "UniProt", "db_id": "P01192" }, { "db_name": "UniProt", "db_id": "P01193" }, { "db_name": "UniProt", "db_id": "P01194" }, { "db_name": "UniProt", "db_id": "P01196" }, { "db_name": "UniProt", "db_id": "P01197" }, { "db_name": "UniProt", "db_id": "P01201" }, { "db_name": "UniProt", "db_id": "P06297" }, { "db_name": "UniProt", "db_id": "P06298" }, { "db_name": "UniProt", "db_id": "P06299" }, { "db_name": "UniProt", "db_id": "P10000" }, { "db_name": "UniProt", "db_id": "P11280" }, { "db_name": "UniProt", "db_id": "P11885" }, { "db_name": "UniProt", "db_id": "P19402" }, { "db_name": "UniProt", "db_id": "P21252" }, { "db_name": "UniProt", "db_id": "P22923" }, { "db_name": "UniProt", "db_id": "P68000" }, { "db_name": "UniProt", "db_id": "P68001" }, { "db_name": "UniProt", "db_id": "P87352" }, { "db_name": "UniProt", "db_id": "Q04617" }, { "db_name": "UniProt", "db_id": "Q04618" }, { "db_name": "UniProt", "db_id": "Q91082" }, { "db_name": "UniProt", "db_id": "Q9YGK2" }, { "db_name": "UniProt", "db_id": "Q9YGK4" }, { "db_name": "UniProt", "db_id": "Q9YGK5" } ] }, { "id": "DS.d1710.s0.e2", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 206, 214 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] }, { "id": "DS.d1710.s1.e0", "type": "protein", "text": [ "ACTH" ], "offsets": [ [ 465, 469 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01189" }, { "db_name": "UniProt", "db_id": "P01190" }, { "db_name": "UniProt", "db_id": "P01191" }, { "db_name": "UniProt", "db_id": "P01192" }, { "db_name": "UniProt", "db_id": "P01193" }, { "db_name": "UniProt", "db_id": "P01194" }, { "db_name": "UniProt", "db_id": "P01196" }, { "db_name": "UniProt", "db_id": "P01197" }, { "db_name": "UniProt", "db_id": "P01201" }, { "db_name": "UniProt", "db_id": "P06297" }, { "db_name": "UniProt", "db_id": "P06298" }, { "db_name": "UniProt", "db_id": "P06299" }, { "db_name": "UniProt", "db_id": "P10000" }, { "db_name": "UniProt", "db_id": "P11280" }, { "db_name": "UniProt", "db_id": "P11885" }, { "db_name": "UniProt", "db_id": "P19402" }, { "db_name": "UniProt", "db_id": "P21252" }, { "db_name": "UniProt", "db_id": "P22923" }, { "db_name": "UniProt", "db_id": "P68000" }, { "db_name": "UniProt", "db_id": "P68001" }, { "db_name": "UniProt", "db_id": "P87352" }, { "db_name": "UniProt", "db_id": "Q04617" }, { "db_name": "UniProt", "db_id": "Q04618" }, { "db_name": "UniProt", "db_id": "Q91082" }, { "db_name": "UniProt", "db_id": "Q9YGK2" }, { "db_name": "UniProt", "db_id": "Q9YGK4" }, { "db_name": "UniProt", "db_id": "Q9YGK5" } ] }, { "id": "DS.d1710.s1.e1", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 475, 483 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] } ]

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[ { "id": "DS.d1711.s0", "type": "", "text": [ "The induction of HO-1 by YC-1 was unchanged by the sGC inhibitor, 1H-(1,2,4)oxadiazolo(4,3-alpha)quinozalin-1-one (ODQ) or by the protein kinase pyrimidin-4-ylamine (BAY 41-2272)." ], "offsets": [ [ 0, 179 ] ] } ]

[ { "id": "DS.d1711.s0.e0", "type": "protein", "text": [ "HO-1" ], "offsets": [ [ 17, 21 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P06762" }, { "db_name": "UniProt", "db_id": "P09601" }, { "db_name": "UniProt", "db_id": "P14791" }, { "db_name": "UniProt", "db_id": "P14901" }, { "db_name": "UniProt", "db_id": "P32394" }, { "db_name": "UniProt", "db_id": "Q5E9F2" } ] }, { "id": "DS.d1711.s0.e1", "type": "compound", "text": [ "YC-1" ], "offsets": [ [ 25, 29 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5712" } ] }, { "id": "DS.d1711.s0.e2", "type": "compound", "text": [ "ODQ" ], "offsets": [ [ 115, 118 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1456" } ] }, { "id": "DS.d1711.s0.e3", "type": "compound", "text": [ "pyrimidin-4-ylamine" ], "offsets": [ [ 145, 164 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "68958" } ] }, { "id": "DS.d1711.s0.e4", "type": "compound", "text": [ "BAY 41-2272" ], "offsets": [ [ 166, 177 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "9798973" } ] } ]

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[ { "id": "DS.d1711.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1711.s0.e1", "arg2_id": "DS.d1711.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1712.s1", "type": "", "text": [ "The potentiation was not altered by the beta(1) subunit or mediated by ARA-S metabolites, stimulation of known cannabinoid receptors, G proteins, protein kinases, or Ca(2+)-dependent processes; it was lost after patch excision or after membrane cholesterol depletion but was restored after cholesterol reconstitution." ], "offsets": [ [ 0, 317 ] ] } ]

[ { "id": "DS.d1712.s1.e0", "type": "protein", "text": [ "protein kinases" ], "offsets": [ [ 146, 161 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P00513" }, { "db_name": "UniProt", "db_id": "P25848" } ] }, { "id": "DS.d1712.s1.e1", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 166, 170 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] }, { "id": "DS.d1712.s1.e2", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 245, 256 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] }, { "id": "DS.d1712.s1.e3", "type": "compound", "text": [ "cholesterol" ], "offsets": [ [ 290, 301 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "304" }, { "db_name": "PubChem", "db_id": "5997" }, { "db_name": "PubChem", "db_id": "6432564" }, { "db_name": "PubChem", "db_id": "11025495" } ] } ]

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[ { "id": "DS.d1713.s0", "type": "", "text": [ "Modulation of Rac1 activity by ADMA/DDAH regulates pulmonary endothelial barrier function." ], "offsets": [ [ 0, 90 ] ] } ]

[ { "id": "DS.d1713.s0.e0", "type": "protein", "text": [ "Rac1" ], "offsets": [ [ 14, 18 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P40792" }, { "db_name": "UniProt", "db_id": "P63001" }, { "db_name": "UniProt", "db_id": "Q6RUV5" } ] }, { "id": "DS.d1713.s0.e1", "type": "compound", "text": [ "ADMA" ], "offsets": [ [ 31, 35 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "123831" } ] }, { "id": "DS.d1713.s0.e2", "type": "protein", "text": [ "DDAH" ], "offsets": [ [ 36, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O94760" }, { "db_name": "UniProt", "db_id": "O95865" } ] } ]

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[ { "id": "DS.d1713.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1713.s0.e1", "arg2_id": "DS.d1713.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1714.s0", "type": "", "text": [ "Endometriosis is associated with progesterone resistance in the baboon (Papio anubis) oviduct: evidence based on the localization of oviductal glycoprotein 1 (OVGP1)." ], "offsets": [ [ 0, 166 ] ] }, { "id": "DS.d1714.s1", "type": "", "text": [ "In this study we evaluated OVGP1 and steroid receptor expression in oviducts of baboons with endometriosis during the midsecretory phase and determined whether progesterone resistance associated with endometriosis also occurs in the oviduct." ], "offsets": [ [ 167, 408 ] ] }, { "id": "DS.d1714.s2", "type": "", "text": [ "These data imply that the normal antagonism of progesterone on ESR and OVGP1, which results in their downregulation during the window of implantation, is absent in animals with endometriosis." ], "offsets": [ [ 409, 600 ] ] } ]

[ { "id": "DS.d1714.s0.e0", "type": "compound", "text": [ "progesterone" ], "offsets": [ [ 33, 45 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5994" } ] }, { "id": "DS.d1714.s0.e1", "type": "protein", "text": [ "oviductal glycoprotein" ], "offsets": [ [ 133, 155 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P36718" }, { "db_name": "UniProt", "db_id": "Q12889" }, { "db_name": "UniProt", "db_id": "Q28042" }, { "db_name": "UniProt", "db_id": "Q28542" }, { "db_name": "UniProt", "db_id": "Q28990" }, { "db_name": "UniProt", "db_id": "Q60557" }, { "db_name": "UniProt", "db_id": "Q62010" } ] }, { "id": "DS.d1714.s0.e2", "type": "protein", "text": [ "OVGP1" ], "offsets": [ [ 159, 164 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P36718" }, { "db_name": "UniProt", "db_id": "Q12889" }, { "db_name": "UniProt", "db_id": "Q28042" }, { "db_name": "UniProt", "db_id": "Q28542" }, { "db_name": "UniProt", "db_id": "Q28990" }, { "db_name": "UniProt", "db_id": "Q60557" } ] }, { "id": "DS.d1714.s1.e0", "type": "protein", "text": [ "OVGP1" ], "offsets": [ [ 194, 199 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P36718" }, { "db_name": "UniProt", "db_id": "Q12889" }, { "db_name": "UniProt", "db_id": "Q28042" }, { "db_name": "UniProt", "db_id": "Q28542" }, { "db_name": "UniProt", "db_id": "Q28990" }, { "db_name": "UniProt", "db_id": "Q60557" } ] }, { "id": "DS.d1714.s1.e1", "type": "compound", "text": [ "progesterone" ], "offsets": [ [ 327, 339 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5994" } ] }, { "id": "DS.d1714.s2.e0", "type": "compound", "text": [ "progesterone" ], "offsets": [ [ 456, 468 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5994" } ] }, { "id": "DS.d1714.s2.e1", "type": "protein", "text": [ "ESR" ], "offsets": [ [ 472, 475 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42132" }, { "db_name": "UniProt", "db_id": "P03372" }, { "db_name": "UniProt", "db_id": "P06212" }, { "db_name": "UniProt", "db_id": "P16058" }, { "db_name": "UniProt", "db_id": "P49884" }, { "db_name": "UniProt", "db_id": "P49885" }, { "db_name": "UniProt", "db_id": "P49886" }, { "db_name": "UniProt", "db_id": "P50240" }, { "db_name": "UniProt", "db_id": "P50241" }, { "db_name": "UniProt", "db_id": "P50242" }, { "db_name": "UniProt", "db_id": "P57753" }, { "db_name": "UniProt", "db_id": "Q29040" }, { "db_name": "UniProt", "db_id": "Q53AD2" }, { "db_name": "UniProt", "db_id": "Q91250" }, { "db_name": "UniProt", "db_id": "Q91424" }, { "db_name": "UniProt", "db_id": "Q9PVZ9" }, { "db_name": "UniProt", "db_id": "Q9QZJ5" }, { "db_name": "UniProt", "db_id": "Q9TV98" }, { "db_name": "UniProt", "db_id": "Q9YH33" }, { "db_name": "UniProt", "db_id": "Q9YHZ7" } ] }, { "id": "DS.d1714.s2.e2", "type": "protein", "text": [ "OVGP1" ], "offsets": [ [ 480, 485 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P36718" }, { "db_name": "UniProt", "db_id": "Q12889" }, { "db_name": "UniProt", "db_id": "Q28042" }, { "db_name": "UniProt", "db_id": "Q28542" }, { "db_name": "UniProt", "db_id": "Q28990" }, { "db_name": "UniProt", "db_id": "Q60557" } ] } ]

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[ { "id": "DS.d1714.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1714.s0.e0", "arg2_id": "DS.d1714.s0.e2", "normalized": [] }, { "id": "DS.d1714.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1714.s1.e1", "arg2_id": "DS.d1714.s1.e0", "normalized": [] }, { "id": "DS.d1714.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1714.s2.e0", "arg2_id": "DS.d1714.s2.e2", "normalized": [] }, { "id": "DS.d1714.s2.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1714.s2.e0", "arg2_id": "DS.d1714.s2.e1", "normalized": [] } ]

[ { "id": "DS.d1715.s1", "type": "", "text": [ "In this study, we evaluated the distribution of the principal CD44 ligand hyaluronan (HA) and the expressions of HA synthases (HAS: HAS1, HAS2, and HAS3) during atresia in pig ovaries." ], "offsets": [ [ 0, 184 ] ] } ]

[ { "id": "DS.d1715.s1.e0", "type": "compound", "text": [ "hyaluronan" ], "offsets": [ [ 74, 84 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "24759" } ] }, { "id": "DS.d1715.s1.e1", "type": "protein", "text": [ "HA synthases" ], "offsets": [ [ 113, 125 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P0C0H0" }, { "db_name": "UniProt", "db_id": "P0C0H1" }, { "db_name": "UniProt", "db_id": "Q5X9A9" }, { "db_name": "UniProt", "db_id": "Q8K5G6" }, { "db_name": "UniProt", "db_id": "Q8NKX1" } ] }, { "id": "DS.d1715.s1.e2", "type": "protein", "text": [ "HAS1" ], "offsets": [ [ 132, 136 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q03532" }, { "db_name": "UniProt", "db_id": "Q0UR48" }, { "db_name": "UniProt", "db_id": "Q1EA54" }, { "db_name": "UniProt", "db_id": "Q2GMX1" }, { "db_name": "UniProt", "db_id": "Q4IEK8" }, { "db_name": "UniProt", "db_id": "Q4P6N0" }, { "db_name": "UniProt", "db_id": "Q5AK59" }, { "db_name": "UniProt", "db_id": "Q5KMN6" }, { "db_name": "UniProt", "db_id": "Q6BH93" }, { "db_name": "UniProt", "db_id": "Q6C7D2" }, { "db_name": "UniProt", "db_id": "Q6CXB7" }, { "db_name": "UniProt", "db_id": "Q6FIL3" }, { "db_name": "UniProt", "db_id": "Q74Z73" }, { "db_name": "UniProt", "db_id": "Q92839" } ] }, { "id": "DS.d1715.s1.e3", "type": "protein", "text": [ "HAS2" ], "offsets": [ [ 138, 142 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O57424" }, { "db_name": "UniProt", "db_id": "O97711" }, { "db_name": "UniProt", "db_id": "Q92819" } ] }, { "id": "DS.d1715.s1.e4", "type": "protein", "text": [ "HAS3" ], "offsets": [ [ 148, 152 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O00219" }, { "db_name": "UniProt", "db_id": "O57425" } ] } ]

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[ { "id": "DS.d1717.s0", "type": "", "text": [ "Transgenic mice that overexpress rat angiotensinogen in their proximal tubule cells were given either apocynin, perindopril, or hydralazine while untreated or apocynin-treated non-transgenic littermates served as controls." ], "offsets": [ [ 0, 222 ] ] } ]

[ { "id": "DS.d1717.s0.e0", "type": "protein", "text": [ "angiotensinogen" ], "offsets": [ [ 37, 52 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01016" }, { "db_name": "UniProt", "db_id": "P01017" }, { "db_name": "UniProt", "db_id": "P67885" }, { "db_name": "UniProt", "db_id": "P67886" } ] }, { "id": "DS.d1717.s0.e1", "type": "compound", "text": [ "apocynin" ], "offsets": [ [ 102, 110 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2214" } ] }, { "id": "DS.d1717.s0.e2", "type": "compound", "text": [ "perindopril" ], "offsets": [ [ 112, 123 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "107807" } ] }, { "id": "DS.d1717.s0.e3", "type": "compound", "text": [ "hydralazine" ], "offsets": [ [ 128, 139 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3637" } ] }, { "id": "DS.d1717.s0.e4", "type": "compound", "text": [ "apocynin" ], "offsets": [ [ 159, 167 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2214" } ] } ]

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[ { "id": "DS.d1719.s0", "type": "", "text": [ "Requirement of AQP4 for antidepressive efficiency of fluoxetine : implication in adult hippocampal neurogenesis." ], "offsets": [ [ 0, 112 ] ] }, { "id": "DS.d1719.s1", "type": "", "text": [ "Collectively, these findings suggest that AQP4 is required for the antidepressive action of fluoxetine via regulating adult hippocampal neurogenesis." ], "offsets": [ [ 113, 262 ] ] } ]

[ { "id": "DS.d1719.s0.e0", "type": "protein", "text": [ "AQP4" ], "offsets": [ [ 15, 19 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77750" }, { "db_name": "UniProt", "db_id": "P55087" }, { "db_name": "UniProt", "db_id": "Q5I4F9" }, { "db_name": "UniProt", "db_id": "Q923J4" } ] }, { "id": "DS.d1719.s0.e1", "type": "compound", "text": [ "fluoxetine" ], "offsets": [ [ 53, 63 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3386" } ] }, { "id": "DS.d1719.s1.e0", "type": "protein", "text": [ "AQP4" ], "offsets": [ [ 155, 159 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O77750" }, { "db_name": "UniProt", "db_id": "P55087" }, { "db_name": "UniProt", "db_id": "Q5I4F9" }, { "db_name": "UniProt", "db_id": "Q923J4" } ] }, { "id": "DS.d1719.s1.e1", "type": "compound", "text": [ "fluoxetine" ], "offsets": [ [ 205, 215 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3386" } ] } ]

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[ { "id": "DS.d1719.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1719.s0.e1", "arg2_id": "DS.d1719.s0.e0", "normalized": [] }, { "id": "DS.d1719.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1719.s1.e1", "arg2_id": "DS.d1719.s1.e0", "normalized": [] } ]

[ { "id": "DS.d1720.s0", "type": "", "text": [ "Although no significant change in the apparent K(m) was revealed in animals that exhibited an escalation in the rate of cocaine intake, an increased dopamine uptake rate was found suggesting an upregulation of DAT number in response to a history of high cocaine intake." ], "offsets": [ [ 0, 269 ] ] } ]

[ { "id": "DS.d1720.s0.e0", "type": "compound", "text": [ "dopamine" ], "offsets": [ [ 149, 157 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "681" } ] }, { "id": "DS.d1720.s0.e1", "type": "protein", "text": [ "DAT" ], "offsets": [ [ 210, 213 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P13483" }, { "db_name": "UniProt", "db_id": "P23977" }, { "db_name": "UniProt", "db_id": "P27922" }, { "db_name": "UniProt", "db_id": "Q01959" }, { "db_name": "UniProt", "db_id": "Q03614" }, { "db_name": "UniProt", "db_id": "Q61327" }, { "db_name": "UniProt", "db_id": "Q9GJT6" } ] } ]

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[ { "id": "DS.d1720.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1720.s0.e0", "arg2_id": "DS.d1720.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1721.s0", "type": "", "text": [ "Previous work has shown that repeated desipramine treatment causes downregulation of the norepinephrine transporter (NET) and persistent antidepressant-like effects on behavior, ie effects observed 2 days after discontinuation of drug treatment when acute effects are minimized." ], "offsets": [ [ 0, 278 ] ] }, { "id": "DS.d1721.s1", "type": "", "text": [ "Treatment for 14 days with 70 mg/kg per day venlafaxine, which inhibits both the NET and SERT, or 10 mg/kg per day phenelzine, a monoamine oxidase inhibitor, produced antidepressant-like effects on behavior without altering NET or SERT expression." ], "offsets": [ [ 279, 526 ] ] } ]

[ { "id": "DS.d1721.s0.e0", "type": "compound", "text": [ "desipramine" ], "offsets": [ [ 38, 49 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2995" } ] }, { "id": "DS.d1721.s0.e1", "type": "protein", "text": [ "norepinephrine transporter" ], "offsets": [ [ 89, 115 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O55192" }, { "db_name": "UniProt", "db_id": "P23975" }, { "db_name": "UniProt", "db_id": "P51143" } ] }, { "id": "DS.d1721.s0.e2", "type": "protein", "text": [ "NET" ], "offsets": [ [ 117, 120 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O55192" }, { "db_name": "UniProt", "db_id": "P23975" }, { "db_name": "UniProt", "db_id": "P41970" }, { "db_name": "UniProt", "db_id": "P51143" }, { "db_name": "UniProt", "db_id": "P54762" } ] }, { "id": "DS.d1721.s1.e0", "type": "protein", "text": [ "NET" ], "offsets": [ [ 360, 363 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O55192" }, { "db_name": "UniProt", "db_id": "P23975" }, { "db_name": "UniProt", "db_id": "P41970" }, { "db_name": "UniProt", "db_id": "P51143" }, { "db_name": "UniProt", "db_id": "P54762" } ] }, { "id": "DS.d1721.s1.e1", "type": "protein", "text": [ "SERT" ], "offsets": [ [ 368, 372 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31645" }, { "db_name": "UniProt", "db_id": "Q9XT49" } ] }, { "id": "DS.d1721.s1.e2", "type": "compound", "text": [ "phenelzine" ], "offsets": [ [ 394, 404 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "3675" } ] }, { "id": "DS.d1721.s1.e3", "type": "protein", "text": [ "NET" ], "offsets": [ [ 503, 506 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O55192" }, { "db_name": "UniProt", "db_id": "P23975" }, { "db_name": "UniProt", "db_id": "P41970" }, { "db_name": "UniProt", "db_id": "P51143" }, { "db_name": "UniProt", "db_id": "P54762" } ] }, { "id": "DS.d1721.s1.e4", "type": "protein", "text": [ "SERT" ], "offsets": [ [ 510, 514 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31645" }, { "db_name": "UniProt", "db_id": "Q9XT49" } ] } ]

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[ { "id": "DS.d1721.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1721.s0.e0", "arg2_id": "DS.d1721.s0.e2", "normalized": [] }, { "id": "DS.d1721.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1721.s0.e0", "arg2_id": "DS.d1721.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1722.s0", "type": "", "text": [ "Studies in schizophrenia identify robust decreases in genes for GABA function, including glutamic acid decarboxylase, HINT1, glutamate transport and GluRs, BDNF and TrkB, numerous 14-3-3 protein family members, and decreases in genes for CNS synaptic and metabolic functions, particularly glycolysis and ATP generation." ], "offsets": [ [ 0, 319 ] ] }, { "id": "DS.d1722.s1", "type": "", "text": [ "Brains from persons with major depressive disorder reveal decreased expression for genes in glutamate transport and metabolism, neurotrophic signaling (eg, FGF, BDNF and VGF), and MAP kinase pathways." ], "offsets": [ [ 320, 520 ] ] } ]

[ { "id": "DS.d1722.s0.e0", "type": "protein", "text": [ "HINT1" ], "offsets": [ [ 118, 123 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P49773" }, { "db_name": "UniProt", "db_id": "P62958" }, { "db_name": "UniProt", "db_id": "P80912" }, { "db_name": "UniProt", "db_id": "Q5RF69" } ] }, { "id": "DS.d1722.s0.e1", "type": "compound", "text": [ "glutamate" ], "offsets": [ [ 125, 134 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "611" }, { "db_name": "PubChem", "db_id": "23327" }, { "db_name": "PubChem", "db_id": "33032" } ] }, { "id": "DS.d1722.s0.e2", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 156, 160 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d1722.s0.e3", "type": "protein", "text": [ "TrkB" ], "offsets": [ [ 165, 169 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P45522" } ] }, { "id": "DS.d1722.s0.e4", "type": "protein", "text": [ "14-3-3 protein" ], "offsets": [ [ 180, 194 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O96436" } ] }, { "id": "DS.d1722.s0.e5", "type": "compound", "text": [ "ATP" ], "offsets": [ [ 304, 307 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5957" } ] }, { "id": "DS.d1722.s1.e0", "type": "compound", "text": [ "glutamate" ], "offsets": [ [ 412, 421 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "611" }, { "db_name": "PubChem", "db_id": "23327" }, { "db_name": "PubChem", "db_id": "33032" } ] }, { "id": "DS.d1722.s1.e1", "type": "protein", "text": [ "FGF" ], "offsets": [ [ 476, 479 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O10284" }, { "db_name": "UniProt", "db_id": "P41444" } ] }, { "id": "DS.d1722.s1.e2", "type": "protein", "text": [ "BDNF" ], "offsets": [ [ 481, 485 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O18752" }, { "db_name": "UniProt", "db_id": "O18753" }, { "db_name": "UniProt", "db_id": "O18755" }, { "db_name": "UniProt", "db_id": "O70183" }, { "db_name": "UniProt", "db_id": "O97759" }, { "db_name": "UniProt", "db_id": "P14082" }, { "db_name": "UniProt", "db_id": "P21237" }, { "db_name": "UniProt", "db_id": "P23363" }, { "db_name": "UniProt", "db_id": "P23560" }, { "db_name": "UniProt", "db_id": "P25429" }, { "db_name": "UniProt", "db_id": "P25430" }, { "db_name": "UniProt", "db_id": "P25431" }, { "db_name": "UniProt", "db_id": "P25432" }, { "db_name": "UniProt", "db_id": "Q02193" }, { "db_name": "UniProt", "db_id": "Q06225" }, { "db_name": "UniProt", "db_id": "Q3SAT7" }, { "db_name": "UniProt", "db_id": "Q4L0Y3" }, { "db_name": "UniProt", "db_id": "Q5IS78" }, { "db_name": "UniProt", "db_id": "Q6LCI5" }, { "db_name": "UniProt", "db_id": "Q7YRB4" }, { "db_name": "UniProt", "db_id": "Q90322" }, { "db_name": "UniProt", "db_id": "Q95106" }, { "db_name": "UniProt", "db_id": "Q9TST3" } ] }, { "id": "DS.d1722.s1.e3", "type": "protein", "text": [ "VGF" ], "offsets": [ [ 490, 493 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O15240" }, { "db_name": "UniProt", "db_id": "O57166" }, { "db_name": "UniProt", "db_id": "P20494" }, { "db_name": "UniProt", "db_id": "Q86607" }, { "db_name": "UniProt", "db_id": "Q9JFH4" } ] } ]

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[ { "id": "DS.d1724.s0", "type": "", "text": [ "However, detection of Cu and Zn in superoxide dismutase after PAGE-LA-ICP-MS depends on the conditions of the PAGE method because possible metal losses can occur (either with SDS-PAGE or with native PAGE)." ], "offsets": [ [ 0, 205 ] ] } ]

[ { "id": "DS.d1724.s0.e0", "type": "compound", "text": [ "Cu" ], "offsets": [ [ 22, 24 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "104815" } ] }, { "id": "DS.d1724.s0.e1", "type": "protein", "text": [ "superoxide dismutase" ], "offsets": [ [ 35, 55 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O50258" } ] } ]

[]

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[ { "id": "DS.d1724.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1724.s0.e0", "arg2_id": "DS.d1724.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1725.s0", "type": "", "text": [ "Recent studies have suggested that a decrease in the specific activity of the 2-oxoglutarate dehydrogenase complex (ODHC) is important for glutamate overproduction by Corynebacterium glutamicum." ], "offsets": [ [ 0, 194 ] ] } ]

[ { "id": "DS.d1725.s0.e0", "type": "protein", "text": [ "oxoglutarate dehydrogenase" ], "offsets": [ [ 80, 106 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q89AJ7" } ] }, { "id": "DS.d1725.s0.e1", "type": "compound", "text": [ "glutamate" ], "offsets": [ [ 139, 148 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "611" }, { "db_name": "PubChem", "db_id": "23327" }, { "db_name": "PubChem", "db_id": "33032" } ] } ]

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[ { "id": "DS.d1725.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1725.s0.e1", "arg2_id": "DS.d1725.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1726.s0", "type": "", "text": [ "To evaluate the potential of using heme-containing lipocalin nitrophorin 1 (NP1) as a template for protein engineering, we have replaced the native axial heme-coordinating histidine residue with glycine, alanine, and cysteine." ], "offsets": [ [ 0, 226 ] ] }, { "id": "DS.d1726.s1", "type": "", "text": [ "Two crystal structures of the H60C_ NP1 in complex with imidazole and histamine were solved to 1.7- and 1.96-A resolution, respectively." ], "offsets": [ [ 227, 363 ] ] }, { "id": "DS.d1726.s2", "type": "", "text": [ "Both structures show that the H60C mutation is well tolerated by the protein scaffold and suggest that heme-thiolate coordination in H60C_ NP1 requires some movement of the heme within its binding cavity." ], "offsets": [ [ 364, 568 ] ] } ]

[ { "id": "DS.d1726.s0.e0", "type": "protein", "text": [ "NP1" ], "offsets": [ [ 76, 79 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P47971" }, { "db_name": "UniProt", "db_id": "Q15818" }, { "db_name": "UniProt", "db_id": "Q26239" }, { "db_name": "UniProt", "db_id": "Q62443" } ] }, { "id": "DS.d1726.s0.e2", "type": "compound", "text": [ "histidine" ], "offsets": [ [ 172, 181 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "773" }, { "db_name": "PubChem", "db_id": "6274" } ] }, { "id": "DS.d1726.s0.e3", "type": "compound", "text": [ "glycine" ], "offsets": [ [ 195, 202 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "750" } ] }, { "id": "DS.d1726.s0.e4", "type": "compound", "text": [ "alanine" ], "offsets": [ [ 204, 211 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "602" }, { "db_name": "PubChem", "db_id": "4580" }, { "db_name": "PubChem", "db_id": "5950" }, { "db_name": "PubChem", "db_id": "71080" } ] }, { "id": "DS.d1726.s0.e5", "type": "compound", "text": [ "cysteine" ], "offsets": [ [ 217, 225 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "594" }, { "db_name": "PubChem", "db_id": "5862" }, { "db_name": "PubChem", "db_id": "5360637" } ] }, { "id": "DS.d1726.s1.e0", "type": "protein", "text": [ "NP1" ], "offsets": [ [ 263, 266 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P47971" }, { "db_name": "UniProt", "db_id": "Q15818" }, { "db_name": "UniProt", "db_id": "Q26239" }, { "db_name": "UniProt", "db_id": "Q62443" } ] }, { "id": "DS.d1726.s1.e1", "type": "compound", "text": [ "imidazole" ], "offsets": [ [ 283, 292 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "795" } ] }, { "id": "DS.d1726.s1.e2", "type": "compound", "text": [ "histamine" ], "offsets": [ [ 297, 306 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "774" } ] }, { "id": "DS.d1726.s2.e0", "type": "compound", "text": [ "heme" ], "offsets": [ [ 467, 471 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4971" } ] }, { "id": "DS.d1726.s2.e1", "type": "compound", "text": [ "thiolate" ], "offsets": [ [ 472, 480 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5047209" } ] }, { "id": "DS.d1726.s2.e2", "type": "protein", "text": [ "NP1" ], "offsets": [ [ 503, 506 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P47971" }, { "db_name": "UniProt", "db_id": "Q15818" }, { "db_name": "UniProt", "db_id": "Q26239" }, { "db_name": "UniProt", "db_id": "Q62443" } ] }, { "id": "DS.d1726.s2.e3", "type": "compound", "text": [ "heme" ], "offsets": [ [ 537, 541 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4971" } ] } ]

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[ { "id": "DS.d1726.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1726.s1.e1", "arg2_id": "DS.d1726.s1.e0", "normalized": [] }, { "id": "DS.d1726.s1.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1726.s1.e2", "arg2_id": "DS.d1726.s1.e0", "normalized": [] } ]

[ { "id": "DS.d1727.s0", "type": "", "text": [ "Anticancer effect of celecoxib via COX-2 dependent and independent mechanisms in human gastric cancers cells." ], "offsets": [ [ 0, 109 ] ] } ]

[ { "id": "DS.d1727.s0.e0", "type": "compound", "text": [ "celecoxib" ], "offsets": [ [ 21, 30 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2662" } ] }, { "id": "DS.d1727.s0.e1", "type": "protein", "text": [ "COX-2" ], "offsets": [ [ 35, 40 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O02768" }, { "db_name": "UniProt", "db_id": "O19183" }, { "db_name": "UniProt", "db_id": "O62698" }, { "db_name": "UniProt", "db_id": "O62725" }, { "db_name": "UniProt", "db_id": "P27607" }, { "db_name": "UniProt", "db_id": "P35354" }, { "db_name": "UniProt", "db_id": "P35355" }, { "db_name": "UniProt", "db_id": "P70682" }, { "db_name": "UniProt", "db_id": "P79208" }, { "db_name": "UniProt", "db_id": "Q05769" } ] } ]

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[ { "id": "DS.d1727.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1727.s0.e0", "arg2_id": "DS.d1727.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1728.s0", "type": "", "text": [ "Real-time polymerase chain reaction analysis of hypoxic, NO-sulindac treated PC-3 cells showed downregulation of lysyl oxidase and carbonic anhydrase IX mRNA expression." ], "offsets": [ [ 0, 169 ] ] } ]

[ { "id": "DS.d1728.s0.e0", "type": "compound", "text": [ "sulindac" ], "offsets": [ [ 60, 68 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5352" }, { "db_name": "PubChem", "db_id": "1548885" }, { "db_name": "PubChem", "db_id": "1548887" } ] }, { "id": "DS.d1728.s0.e1", "type": "protein", "text": [ "lysyl oxidase" ], "offsets": [ [ 113, 126 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P16636" }, { "db_name": "UniProt", "db_id": "P28300" }, { "db_name": "UniProt", "db_id": "P28301" }, { "db_name": "UniProt", "db_id": "P33072" }, { "db_name": "UniProt", "db_id": "P45845" }, { "db_name": "UniProt", "db_id": "Q05063" } ] }, { "id": "DS.d1728.s0.e2", "type": "protein", "text": [ "carbonic anhydrase IX" ], "offsets": [ [ 131, 152 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q16790" }, { "db_name": "UniProt", "db_id": "Q8VHB5" } ] } ]

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[ { "id": "DS.d1728.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1728.s0.e0", "arg2_id": "DS.d1728.s0.e2", "normalized": [] }, { "id": "DS.d1728.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1728.s0.e0", "arg2_id": "DS.d1728.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1729.s0", "type": "", "text": [ "Established risk cardiovascular factors like hypertension, atherogenic dyslipidaemia, and glucose intolerance occur in the setting of insulin resistance and central adiposity, with genetic and environmental influences modulating the ultimate risk." ], "offsets": [ [ 0, 247 ] ] } ]

[ { "id": "DS.d1729.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 90, 97 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1729.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 134, 141 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]

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[ { "id": "DS.d1729.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1729.s0.e0", "arg2_id": "DS.d1729.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1730.s0", "type": "", "text": [ "Despite this lack of oxidative and cytotoxic action, exposure of hepatoma cells to Ni(2+) resulted in a significant activation of Akt that was abrogated by inhibitors of PI3K." ], "offsets": [ [ 0, 175 ] ] } ]

[ { "id": "DS.d1730.s0.e0", "type": "compound", "text": [ "Ni(2" ], "offsets": [ [ 83, 87 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "934" } ] }, { "id": "DS.d1730.s0.e1", "type": "protein", "text": [ "Akt" ], "offsets": [ [ 130, 133 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P31750" }, { "db_name": "UniProt", "db_id": "Q8INB9" } ] } ]

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[ { "id": "DS.d1730.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1730.s0.e0", "arg2_id": "DS.d1730.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1731.s0", "type": "", "text": [ "Gas exchange was monitored and blood samples were collected during exercise for GH, ACTH, insulin, and blood glucose and lactate determination." ], "offsets": [ [ 0, 143 ] ] } ]

[ { "id": "DS.d1731.s0.e0", "type": "protein", "text": [ "ACTH" ], "offsets": [ [ 84, 88 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01189" }, { "db_name": "UniProt", "db_id": "P01190" }, { "db_name": "UniProt", "db_id": "P01191" }, { "db_name": "UniProt", "db_id": "P01192" }, { "db_name": "UniProt", "db_id": "P01193" }, { "db_name": "UniProt", "db_id": "P01194" }, { "db_name": "UniProt", "db_id": "P01196" }, { "db_name": "UniProt", "db_id": "P01197" }, { "db_name": "UniProt", "db_id": "P01201" }, { "db_name": "UniProt", "db_id": "P06297" }, { "db_name": "UniProt", "db_id": "P06298" }, { "db_name": "UniProt", "db_id": "P06299" }, { "db_name": "UniProt", "db_id": "P10000" }, { "db_name": "UniProt", "db_id": "P11280" }, { "db_name": "UniProt", "db_id": "P11885" }, { "db_name": "UniProt", "db_id": "P19402" }, { "db_name": "UniProt", "db_id": "P21252" }, { "db_name": "UniProt", "db_id": "P22923" }, { "db_name": "UniProt", "db_id": "P68000" }, { "db_name": "UniProt", "db_id": "P68001" }, { "db_name": "UniProt", "db_id": "P87352" }, { "db_name": "UniProt", "db_id": "Q04617" }, { "db_name": "UniProt", "db_id": "Q04618" }, { "db_name": "UniProt", "db_id": "Q91082" }, { "db_name": "UniProt", "db_id": "Q9YGK2" }, { "db_name": "UniProt", "db_id": "Q9YGK4" }, { "db_name": "UniProt", "db_id": "Q9YGK5" } ] }, { "id": "DS.d1731.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 90, 97 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] }, { "id": "DS.d1731.s0.e2", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 109, 116 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1731.s0.e3", "type": "compound", "text": [ "lactate" ], "offsets": [ [ 121, 128 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "612" } ] } ]

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[ { "id": "DS.d1732.s0", "type": "", "text": [ "The chimera was at least fourfold less sensitive to inhibition by okadaic acid, but was stimulated by nickel ions and chlorogenic acid, characteristics of PP2B not of PP1." ], "offsets": [ [ 0, 171 ] ] } ]

[ { "id": "DS.d1732.s0.e0", "type": "compound", "text": [ "nickel ions" ], "offsets": [ [ 102, 113 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "934" } ] }, { "id": "DS.d1732.s0.e1", "type": "compound", "text": [ "chlorogenic acid" ], "offsets": [ [ 118, 134 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1794427" } ] }, { "id": "DS.d1732.s0.e2", "type": "protein", "text": [ "PP2B" ], "offsets": [ [ 155, 159 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P07978" } ] }, { "id": "DS.d1732.s0.e3", "type": "protein", "text": [ "PP1" ], "offsets": [ [ 167, 170 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P22198" }, { "db_name": "UniProt", "db_id": "P30366" }, { "db_name": "UniProt", "db_id": "P48487" }, { "db_name": "UniProt", "db_id": "P48488" }, { "db_name": "UniProt", "db_id": "P50391" }, { "db_name": "UniProt", "db_id": "P80074" }, { "db_name": "UniProt", "db_id": "Q61041" }, { "db_name": "UniProt", "db_id": "Q63447" } ] } ]

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[ { "id": "DS.d1732.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1732.s0.e1", "arg2_id": "DS.d1732.s0.e2", "normalized": [] }, { "id": "DS.d1732.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1732.s0.e0", "arg2_id": "DS.d1732.s0.e2", "normalized": [] } ]

[ { "id": "DS.d1733.s0", "type": "", "text": [ "Because o-quinones are very unstable, we used an oxymetric method to characterize the kinetics of this substrate, based on measurements of the oxygen consumed in the tyrosinase reaction." ], "offsets": [ [ 0, 186 ] ] } ]

[ { "id": "DS.d1733.s0.e0", "type": "compound", "text": [ "oxygen" ], "offsets": [ [ 143, 149 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "977" } ] }, { "id": "DS.d1733.s0.e1", "type": "protein", "text": [ "tyrosinase" ], "offsets": [ [ 166, 176 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O42713" }, { "db_name": "UniProt", "db_id": "P06845" }, { "db_name": "UniProt", "db_id": "P07524" }, { "db_name": "UniProt", "db_id": "P33180" }, { "db_name": "UniProt", "db_id": "P55022" }, { "db_name": "UniProt", "db_id": "P55023" }, { "db_name": "UniProt", "db_id": "P55033" }, { "db_name": "UniProt", "db_id": "Q00234" }, { "db_name": "UniProt", "db_id": "Q8J130" }, { "db_name": "UniProt", "db_id": "Q92396" } ] } ]

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[ { "id": "DS.d1733.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1733.s0.e0", "arg2_id": "DS.d1733.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1734.s0", "type": "", "text": [ "Plasma levels of citalopram, cortisol, and prolactin were measured." ], "offsets": [ [ 0, 67 ] ] }, { "id": "DS.d1734.s1", "type": "", "text": [ "An increase in cortisol and prolactin concentrations was observed from the EOI until 60 min after the EOI." ], "offsets": [ [ 68, 174 ] ] } ]

[ { "id": "DS.d1734.s0.e0", "type": "compound", "text": [ "citalopram" ], "offsets": [ [ 17, 27 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "2771" }, { "db_name": "PubChem", "db_id": "146570" } ] }, { "id": "DS.d1734.s0.e1", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 29, 37 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] }, { "id": "DS.d1734.s0.e2", "type": "protein", "text": [ "prolactin" ], "offsets": [ [ 43, 52 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10765" }, { "db_name": "UniProt", "db_id": "P22393" }, { "db_name": "UniProt", "db_id": "P33089" }, { "db_name": "UniProt", "db_id": "P33090" }, { "db_name": "UniProt", "db_id": "P33091" }, { "db_name": "UniProt", "db_id": "P43001" } ] }, { "id": "DS.d1734.s1.e0", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 83, 91 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] }, { "id": "DS.d1734.s1.e1", "type": "protein", "text": [ "prolactin" ], "offsets": [ [ 96, 105 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10765" }, { "db_name": "UniProt", "db_id": "P22393" }, { "db_name": "UniProt", "db_id": "P33089" }, { "db_name": "UniProt", "db_id": "P33090" }, { "db_name": "UniProt", "db_id": "P33091" }, { "db_name": "UniProt", "db_id": "P43001" } ] } ]

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[ { "id": "DS.d1735.s0", "type": "", "text": [ "Different lag-time of pulse-released nerve growth factor (NGF) from genipin-crosslinked gelatin within polycaprolactone (PCL) conduits was evaluated in large-gap peripheral nerve repair." ], "offsets": [ [ 0, 186 ] ] }, { "id": "DS.d1735.s1", "type": "", "text": [ "In this study, 10% (w/v) gelatin was mixed with NGF, crosslinked with 0%, 0.1%, 0.5%, and 1% (w/v) genipin, and then sucked into the wall of PCL conduits." ], "offsets": [ [ 187, 341 ] ] } ]

[ { "id": "DS.d1735.s0.e0", "type": "protein", "text": [ "NGF" ], "offsets": [ [ 58, 61 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21617" }, { "db_name": "UniProt", "db_id": "P34129" }, { "db_name": "UniProt", "db_id": "Q6YBR5" }, { "db_name": "UniProt", "db_id": "Q90W38" } ] }, { "id": "DS.d1735.s0.e1", "type": "compound", "text": [ "genipin" ], "offsets": [ [ 68, 75 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23340" }, { "db_name": "PubChem", "db_id": "442424" }, { "db_name": "PubChem", "db_id": "44144320" } ] }, { "id": "DS.d1735.s0.e2", "type": "compound", "text": [ "polycaprolactone" ], "offsets": [ [ 103, 119 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "10401" } ] }, { "id": "DS.d1735.s1.e0", "type": "protein", "text": [ "NGF" ], "offsets": [ [ 235, 238 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P21617" }, { "db_name": "UniProt", "db_id": "P34129" }, { "db_name": "UniProt", "db_id": "Q6YBR5" }, { "db_name": "UniProt", "db_id": "Q90W38" } ] }, { "id": "DS.d1735.s1.e1", "type": "compound", "text": [ "genipin" ], "offsets": [ [ 286, 293 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "23340" }, { "db_name": "PubChem", "db_id": "442424" }, { "db_name": "PubChem", "db_id": "44144320" } ] } ]

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[ { "id": "DS.d1737.s0", "type": "", "text": [ "It was found from this group that 4-hydroxycoumarin was the best alternative to warfarin for examining the interactions of drugs at Sudlow site I on HSA." ], "offsets": [ [ 0, 153 ] ] } ]

[ { "id": "DS.d1737.s0.e0", "type": "compound", "text": [ "4-hydroxycoumarin" ], "offsets": [ [ 34, 51 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54682930" } ] }, { "id": "DS.d1737.s0.e1", "type": "protein", "text": [ "HSA" ], "offsets": [ [ 149, 152 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P24807" }, { "db_name": "UniProt", "db_id": "Q07490" } ] } ]

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[ { "id": "DS.d1737.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1737.s0.e0", "arg2_id": "DS.d1737.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1738.s0", "type": "", "text": [ "Effects of DRD2/ANKK1 gene variations and clinical factors on aripiprazole efficacy in schizophrenic patients." ], "offsets": [ [ 0, 110 ] ] } ]

[ { "id": "DS.d1738.s0.e0", "type": "protein", "text": [ "DRD2" ], "offsets": [ [ 11, 15 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O73810" }, { "db_name": "UniProt", "db_id": "P14416" }, { "db_name": "UniProt", "db_id": "P20288" }, { "db_name": "UniProt", "db_id": "P52702" }, { "db_name": "UniProt", "db_id": "P60026" }, { "db_name": "UniProt", "db_id": "Q6TLI9" }, { "db_name": "UniProt", "db_id": "Q9GJU1" } ] }, { "id": "DS.d1738.s0.e1", "type": "protein", "text": [ "ANKK1" ], "offsets": [ [ 16, 21 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q8NFD2" } ] }, { "id": "DS.d1738.s0.e2", "type": "compound", "text": [ "aripiprazole" ], "offsets": [ [ 62, 74 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "60795" } ] } ]

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[ { "id": "DS.d1738.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1738.s0.e2", "arg2_id": "DS.d1738.s0.e0", "normalized": [] }, { "id": "DS.d1738.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1738.s0.e2", "arg2_id": "DS.d1738.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1739.s0", "type": "", "text": [ "The majority of patients with acute depression shows an exaggerated plasma corticotrophin (ACTH) and cortisol response to this test that normalizes gradually during successful antidepressant therapy." ], "offsets": [ [ 0, 199 ] ] }, { "id": "DS.d1739.s1", "type": "", "text": [ "We examined plasma ACTH and cortisol responses to the dex/CRH test in acutely depressed inpatients treated either with mirtazapine (n=55) or a monoamine reuptake inhibitor (n=105) according to doctor's choice and compared the test results with healthy controls (n=40)." ], "offsets": [ [ 200, 468 ] ] } ]

[ { "id": "DS.d1739.s0.e0", "type": "protein", "text": [ "ACTH" ], "offsets": [ [ 91, 95 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01189" }, { "db_name": "UniProt", "db_id": "P01190" }, { "db_name": "UniProt", "db_id": "P01191" }, { "db_name": "UniProt", "db_id": "P01192" }, { "db_name": "UniProt", "db_id": "P01193" }, { "db_name": "UniProt", "db_id": "P01194" }, { "db_name": "UniProt", "db_id": "P01196" }, { "db_name": "UniProt", "db_id": "P01197" }, { "db_name": "UniProt", "db_id": "P01201" }, { "db_name": "UniProt", "db_id": "P06297" }, { "db_name": "UniProt", "db_id": "P06298" }, { "db_name": "UniProt", "db_id": "P06299" }, { "db_name": "UniProt", "db_id": "P10000" }, { "db_name": "UniProt", "db_id": "P11280" }, { "db_name": "UniProt", "db_id": "P11885" }, { "db_name": "UniProt", "db_id": "P19402" }, { "db_name": "UniProt", "db_id": "P21252" }, { "db_name": "UniProt", "db_id": "P22923" }, { "db_name": "UniProt", "db_id": "P68000" }, { "db_name": "UniProt", "db_id": "P68001" }, { "db_name": "UniProt", "db_id": "P87352" }, { "db_name": "UniProt", "db_id": "Q04617" }, { "db_name": "UniProt", "db_id": "Q04618" }, { "db_name": "UniProt", "db_id": "Q91082" }, { "db_name": "UniProt", "db_id": "Q9YGK2" }, { "db_name": "UniProt", "db_id": "Q9YGK4" }, { "db_name": "UniProt", "db_id": "Q9YGK5" } ] }, { "id": "DS.d1739.s0.e1", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 101, 109 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] }, { "id": "DS.d1739.s1.e0", "type": "protein", "text": [ "ACTH" ], "offsets": [ [ 219, 223 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01189" }, { "db_name": "UniProt", "db_id": "P01190" }, { "db_name": "UniProt", "db_id": "P01191" }, { "db_name": "UniProt", "db_id": "P01192" }, { "db_name": "UniProt", "db_id": "P01193" }, { "db_name": "UniProt", "db_id": "P01194" }, { "db_name": "UniProt", "db_id": "P01196" }, { "db_name": "UniProt", "db_id": "P01197" }, { "db_name": "UniProt", "db_id": "P01201" }, { "db_name": "UniProt", "db_id": "P06297" }, { "db_name": "UniProt", "db_id": "P06298" }, { "db_name": "UniProt", "db_id": "P06299" }, { "db_name": "UniProt", "db_id": "P10000" }, { "db_name": "UniProt", "db_id": "P11280" }, { "db_name": "UniProt", "db_id": "P11885" }, { "db_name": "UniProt", "db_id": "P19402" }, { "db_name": "UniProt", "db_id": "P21252" }, { "db_name": "UniProt", "db_id": "P22923" }, { "db_name": "UniProt", "db_id": "P68000" }, { "db_name": "UniProt", "db_id": "P68001" }, { "db_name": "UniProt", "db_id": "P87352" }, { "db_name": "UniProt", "db_id": "Q04617" }, { "db_name": "UniProt", "db_id": "Q04618" }, { "db_name": "UniProt", "db_id": "Q91082" }, { "db_name": "UniProt", "db_id": "Q9YGK2" }, { "db_name": "UniProt", "db_id": "Q9YGK4" }, { "db_name": "UniProt", "db_id": "Q9YGK5" } ] }, { "id": "DS.d1739.s1.e1", "type": "compound", "text": [ "cortisol" ], "offsets": [ [ 228, 236 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "5754" } ] } ]

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[ { "id": "DS.d1740.s0", "type": "", "text": [ "Both extracts increased AMP-kinase phosphorylation and HMG-CoA reductase phosphorylation by 2.5-to 4-fold, but with different time courses: maximal phosphorylation with green tea was evident within 30 min of treatment, whereas with black tea phosphorylation was slower to develop, with maximal phosphorylation occurring > or =3 hours after treatment." ], "offsets": [ [ 0, 353 ] ] } ]

[ { "id": "DS.d1740.s0.e1", "type": "protein", "text": [ "HMG-CoA reductase" ], "offsets": [ [ 55, 72 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O08424" }, { "db_name": "UniProt", "db_id": "O24594" }, { "db_name": "UniProt", "db_id": "O26662" }, { "db_name": "UniProt", "db_id": "O28538" }, { "db_name": "UniProt", "db_id": "O51628" }, { "db_name": "UniProt", "db_id": "O59469" }, { "db_name": "UniProt", "db_id": "O74164" }, { "db_name": "UniProt", "db_id": "O76819" }, { "db_name": "UniProt", "db_id": "P00347" }, { "db_name": "UniProt", "db_id": "P04035" }, { "db_name": "UniProt", "db_id": "P09610" }, { "db_name": "UniProt", "db_id": "P13702" }, { "db_name": "UniProt", "db_id": "P14773" }, { "db_name": "UniProt", "db_id": "P16237" }, { "db_name": "UniProt", "db_id": "P16393" }, { "db_name": "UniProt", "db_id": "P20715" }, { "db_name": "UniProt", "db_id": "P48021" }, { "db_name": "UniProt", "db_id": "P51639" }, { "db_name": "UniProt", "db_id": "P54960" }, { "db_name": "UniProt", "db_id": "Q01237" }, { "db_name": "UniProt", "db_id": "Q01559" }, { "db_name": "UniProt", "db_id": "Q03163" }, { "db_name": "UniProt", "db_id": "Q10283" }, { "db_name": "UniProt", "db_id": "Q12577" }, { "db_name": "UniProt", "db_id": "Q12649" }, { "db_name": "UniProt", "db_id": "Q1W675" }, { "db_name": "UniProt", "db_id": "Q29512" }, { "db_name": "UniProt", "db_id": "Q58116" }, { "db_name": "UniProt", "db_id": "Q59468" }, { "db_name": "UniProt", "db_id": "Q5R6N3" }, { "db_name": "UniProt", "db_id": "Q9V1R3" }, { "db_name": "UniProt", "db_id": "Q9Y7D2" }, { "db_name": "UniProt", "db_id": "Q9YAS4" } ] }, { "id": "DS.d1740.s0.e2", "type": "compound", "text": [ "green tea" ], "offsets": [ [ 169, 178 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "4630" } ] } ]

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[ { "id": "DS.d1740.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1740.s0.e2", "arg2_id": "DS.d1740.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1741.s0", "type": "", "text": [ "However, the ethyl ester of commipheric acid (150 mg/kg, twice daily) lowered fasting blood glucose and plasma insulin, and plasma triglycerides without affecting food intake or body weight." ], "offsets": [ [ 0, 190 ] ] } ]

[ { "id": "DS.d1741.s0.e0", "type": "compound", "text": [ "glucose" ], "offsets": [ [ 92, 99 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "206" }, { "db_name": "PubChem", "db_id": "5793" }, { "db_name": "PubChem", "db_id": "64689" }, { "db_name": "PubChem", "db_id": "79025" } ] }, { "id": "DS.d1741.s0.e1", "type": "protein", "text": [ "insulin" ], "offsets": [ [ 111, 118 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P01314" }, { "db_name": "UniProt", "db_id": "P01316" }, { "db_name": "UniProt", "db_id": "P01319" }, { "db_name": "UniProt", "db_id": "P01320" }, { "db_name": "UniProt", "db_id": "P01324" }, { "db_name": "UniProt", "db_id": "P01328" }, { "db_name": "UniProt", "db_id": "P01330" }, { "db_name": "UniProt", "db_id": "P01331" }, { "db_name": "UniProt", "db_id": "P01334" }, { "db_name": "UniProt", "db_id": "P01336" }, { "db_name": "UniProt", "db_id": "P01340" }, { "db_name": "UniProt", "db_id": "P07453" }, { "db_name": "UniProt", "db_id": "P09476" }, { "db_name": "UniProt", "db_id": "P09477" }, { "db_name": "UniProt", "db_id": "P0C236" }, { "db_name": "UniProt", "db_id": "P12703" }, { "db_name": "UniProt", "db_id": "P12704" }, { "db_name": "UniProt", "db_id": "P12708" }, { "db_name": "UniProt", "db_id": "P13190" }, { "db_name": "UniProt", "db_id": "P18109" }, { "db_name": "UniProt", "db_id": "P29335" }, { "db_name": "UniProt", "db_id": "P42633" }, { "db_name": "UniProt", "db_id": "P67968" }, { "db_name": "UniProt", "db_id": "P67969" }, { "db_name": "UniProt", "db_id": "P67971" }, { "db_name": "UniProt", "db_id": "P67973" }, { "db_name": "UniProt", "db_id": "P67974" }, { "db_name": "UniProt", "db_id": "P68243" }, { "db_name": "UniProt", "db_id": "P68245" }, { "db_name": "UniProt", "db_id": "P68987" }, { "db_name": "UniProt", "db_id": "P68988" }, { "db_name": "UniProt", "db_id": "P68989" }, { "db_name": "UniProt", "db_id": "P68990" }, { "db_name": "UniProt", "db_id": "P68991" }, { "db_name": "UniProt", "db_id": "P68992" }, { "db_name": "UniProt", "db_id": "P69046" }, { "db_name": "UniProt", "db_id": "P69047" }, { "db_name": "UniProt", "db_id": "P69048" }, { "db_name": "UniProt", "db_id": "P81423" }, { "db_name": "UniProt", "db_id": "P81881" }, { "db_name": "UniProt", "db_id": "Q9TQY7" } ] } ]

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[ { "id": "DS.d1743.s0", "type": "", "text": [ "This finding led the authors to propose that RDH-E2 may be involved in the pathogenesis of psoriasis through its potential role in retinoic acid biosynthesis and stimulation of keratinocyte proliferation." ], "offsets": [ [ 0, 204 ] ] }, { "id": "DS.d1743.s1", "type": "", "text": [ "In this study, we began the characterization of RDH-E2 protein in order to determine whether it might play a role in retinoic acid biosynthesis." ], "offsets": [ [ 205, 349 ] ] }, { "id": "DS.d1743.s2", "type": "", "text": [ "The preference for NAD(+) suggests that RDH-E2 is likely to function in the oxidative direction in vivo, further supporting its potential role in the oxidation of retinol to retinaldehyde for retinoic acid biosynthesis in human keratinocytes." ], "offsets": [ [ 350, 592 ] ] } ]

[ { "id": "DS.d1743.s0.e0", "type": "protein", "text": [ "RDH-E2" ], "offsets": [ [ 45, 51 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9BPW9" } ] }, { "id": "DS.d1743.s0.e1", "type": "compound", "text": [ "retinoic acid" ], "offsets": [ [ 131, 144 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444795" } ] }, { "id": "DS.d1743.s1.e0", "type": "protein", "text": [ "RDH-E2" ], "offsets": [ [ 253, 259 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9BPW9" } ] }, { "id": "DS.d1743.s1.e1", "type": "compound", "text": [ "retinoic acid" ], "offsets": [ [ 322, 335 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444795" } ] }, { "id": "DS.d1743.s2.e0", "type": "protein", "text": [ "RDH-E2" ], "offsets": [ [ 390, 396 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q9BPW9" } ] }, { "id": "DS.d1743.s2.e1", "type": "compound", "text": [ "retinoic acid" ], "offsets": [ [ 542, 555 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444795" } ] } ]

[]

[]

[ { "id": "DS.d1743.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1743.s0.e1", "arg2_id": "DS.d1743.s0.e0", "normalized": [] }, { "id": "DS.d1743.s2.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1743.s2.e1", "arg2_id": "DS.d1743.s2.e0", "normalized": [] } ]

[ { "id": "DS.d1744.s0", "type": "", "text": [ "Identification of Aldh1a, Cyp26 and RAR orthologs in protostomes pushes back the retinoic acid genetic machinery in evolutionary time to the bilaterian ancestor." ], "offsets": [ [ 0, 161 ] ] } ]

[ { "id": "DS.d1744.s0.e0", "type": "protein", "text": [ "Cyp26" ], "offsets": [ [ 26, 31 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O55127" }, { "db_name": "UniProt", "db_id": "O93323" }, { "db_name": "UniProt", "db_id": "P79739" } ] }, { "id": "DS.d1744.s0.e1", "type": "compound", "text": [ "retinoic acid" ], "offsets": [ [ 81, 94 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "444795" } ] } ]

[]

[]

[ { "id": "DS.d1744.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1744.s0.e1", "arg2_id": "DS.d1744.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1745.s1", "type": "", "text": [ "As release of NADH can be a rate-limiting step for ALDH activity, NADH binding was evaluated for R166wt and R166H enzymes." ], "offsets": [ [ 0, 122 ] ] } ]

[ { "id": "DS.d1745.s1.e0", "type": "compound", "text": [ "NADH" ], "offsets": [ [ 14, 18 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "439153" } ] }, { "id": "DS.d1745.s1.e1", "type": "protein", "text": [ "ALDH" ], "offsets": [ [ 51, 55 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P17201" }, { "db_name": "UniProt", "db_id": "P22281" }, { "db_name": "UniProt", "db_id": "P80472" }, { "db_name": "UniProt", "db_id": "P80704" }, { "db_name": "UniProt", "db_id": "P80705" }, { "db_name": "UniProt", "db_id": "Q27640" }, { "db_name": "UniProt", "db_id": "Q8VXQ2" } ] } ]

[]

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[ { "id": "DS.d1745.s1.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1745.s1.e0", "arg2_id": "DS.d1745.s1.e1", "normalized": [] } ]

[ { "id": "DS.d1747.s0", "type": "", "text": [ "GSH is the most powerful intracellular antioxidant and plays a role in the detoxification of a variety of electrophilic compounds and peroxides via catalysis by glutathione-S-transferases (GST) and glutathione peroxidases (GPx)." ], "offsets": [ [ 0, 228 ] ] } ]

[ { "id": "DS.d1747.s0.e0", "type": "compound", "text": [ "GSH" ], "offsets": [ [ 0, 3 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "124886" } ] }, { "id": "DS.d1747.s0.e1", "type": "protein", "text": [ "glutathione-S-transferases" ], "offsets": [ [ 161, 187 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O04437" }, { "db_name": "UniProt", "db_id": "O18598" }, { "db_name": "UniProt", "db_id": "P0A9D2" }, { "db_name": "UniProt", "db_id": "P0A9D3" }, { "db_name": "UniProt", "db_id": "P30116" }, { "db_name": "UniProt", "db_id": "P44521" }, { "db_name": "UniProt", "db_id": "P46088" }, { "db_name": "UniProt", "db_id": "P46419" }, { "db_name": "UniProt", "db_id": "P46423" }, { "db_name": "UniProt", "db_id": "P46426" }, { "db_name": "UniProt", "db_id": "P46428" }, { "db_name": "UniProt", "db_id": "P46437" }, { "db_name": "UniProt", "db_id": "P48438" }, { "db_name": "UniProt", "db_id": "P80894" }, { "db_name": "UniProt", "db_id": "P81065" }, { "db_name": "UniProt", "db_id": "P82996" }, { "db_name": "UniProt", "db_id": "P82997" }, { "db_name": "UniProt", "db_id": "P82998" }, { "db_name": "UniProt", "db_id": "P82999" }, { "db_name": "UniProt", "db_id": "P83000" }, { "db_name": "UniProt", "db_id": "P83001" }, { "db_name": "UniProt", "db_id": "P83246" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q08392" }, { "db_name": "UniProt", "db_id": "Q08393" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" }, { "db_name": "UniProt", "db_id": "Q96324" } ] }, { "id": "DS.d1747.s0.e2", "type": "protein", "text": [ "GST" ], "offsets": [ [ 189, 192 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P20432" }, { "db_name": "UniProt", "db_id": "P30104" }, { "db_name": "UniProt", "db_id": "P30106" }, { "db_name": "UniProt", "db_id": "P30107" }, { "db_name": "UniProt", "db_id": "P30108" }, { "db_name": "UniProt", "db_id": "Q04522" }, { "db_name": "UniProt", "db_id": "Q0ZS46" }, { "db_name": "UniProt", "db_id": "Q7REH6" }, { "db_name": "UniProt", "db_id": "Q8ILQ7" }, { "db_name": "UniProt", "db_id": "Q8MU52" } ] }, { "id": "DS.d1747.s0.e3", "type": "protein", "text": [ "glutathione peroxidases" ], "offsets": [ [ 198, 221 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O32770" }, { "db_name": "UniProt", "db_id": "O59858" }, { "db_name": "UniProt", "db_id": "Q00277" }, { "db_name": "UniProt", "db_id": "Q9CFV1" } ] } ]

[]

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[ { "id": "DS.d1747.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1747.s0.e0", "arg2_id": "DS.d1747.s0.e2", "normalized": [] }, { "id": "DS.d1747.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1747.s0.e0", "arg2_id": "DS.d1747.s0.e3", "normalized": [] }, { "id": "DS.d1747.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1747.s0.e0", "arg2_id": "DS.d1747.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1748.s0", "type": "", "text": [ "Peripheral GLP-1 gastroprotection against ethanol : the role of exendin, NO, CGRP, prostaglandins and blood flow." ], "offsets": [ [ 0, 113 ] ] }, { "id": "DS.d1748.s1", "type": "", "text": [ "Absolute ethanol was administered through an orogastric cannula right after the injection of GLP-1 (1, 10, 100, 1000 or 10,000 ng/kg; i.p.)." ], "offsets": [ [ 114, 254 ] ] } ]

[ { "id": "DS.d1748.s0.e0", "type": "protein", "text": [ "GLP-1" ], "offsets": [ [ 11, 16 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12956" }, { "db_name": "UniProt", "db_id": "P01272" }, { "db_name": "UniProt", "db_id": "P01273" }, { "db_name": "UniProt", "db_id": "P01274" }, { "db_name": "UniProt", "db_id": "P01275" }, { "db_name": "UniProt", "db_id": "P05110" }, { "db_name": "UniProt", "db_id": "P06883" }, { "db_name": "UniProt", "db_id": "P22890" }, { "db_name": "UniProt", "db_id": "P29794" }, { "db_name": "UniProt", "db_id": "P55095" }, { "db_name": "UniProt", "db_id": "P68259" }, { "db_name": "UniProt", "db_id": "Q06605" }, { "db_name": "UniProt", "db_id": "Q8MJ25" } ] }, { "id": "DS.d1748.s0.e1", "type": "compound", "text": [ "ethanol" ], "offsets": [ [ 42, 49 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "702" } ] }, { "id": "DS.d1748.s0.e2", "type": "protein", "text": [ "CGRP" ], "offsets": [ [ 77, 81 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P10286" }, { "db_name": "UniProt", "db_id": "P30880" }, { "db_name": "UniProt", "db_id": "P30881" }, { "db_name": "UniProt", "db_id": "P31888" }, { "db_name": "UniProt", "db_id": "P80511" } ] }, { "id": "DS.d1748.s1.e0", "type": "compound", "text": [ "Absolute ethanol" ], "offsets": [ [ 114, 130 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "702" } ] }, { "id": "DS.d1748.s1.e1", "type": "protein", "text": [ "GLP-1" ], "offsets": [ [ 207, 212 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O12956" }, { "db_name": "UniProt", "db_id": "P01272" }, { "db_name": "UniProt", "db_id": "P01273" }, { "db_name": "UniProt", "db_id": "P01274" }, { "db_name": "UniProt", "db_id": "P01275" }, { "db_name": "UniProt", "db_id": "P05110" }, { "db_name": "UniProt", "db_id": "P06883" }, { "db_name": "UniProt", "db_id": "P22890" }, { "db_name": "UniProt", "db_id": "P29794" }, { "db_name": "UniProt", "db_id": "P55095" }, { "db_name": "UniProt", "db_id": "P68259" }, { "db_name": "UniProt", "db_id": "Q06605" }, { "db_name": "UniProt", "db_id": "Q8MJ25" } ] } ]

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[ { "id": "DS.d1749.s0", "type": "", "text": [ "It inhibited Trypanosoma brucei GAPDH with an IC(50) value of 240 microM and has been shown to be a competitive reversible inhibitor (Ki=200+/-10 microM) of this enzyme with respect to its cofactor NAD (+)." ], "offsets": [ [ 0, 206 ] ] } ]

[ { "id": "DS.d1749.s0.e0", "type": "protein", "text": [ "GAPDH" ], "offsets": [ [ 32, 37 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "O01360" }, { "db_name": "UniProt", "db_id": "O13507" }, { "db_name": "UniProt", "db_id": "O27090" }, { "db_name": "UniProt", "db_id": "O28542" }, { "db_name": "UniProt", "db_id": "O32755" }, { "db_name": "UniProt", "db_id": "O34425" }, { "db_name": "UniProt", "db_id": "O42259" }, { "db_name": "UniProt", "db_id": "O52631" }, { "db_name": "UniProt", "db_id": "O57479" }, { "db_name": "UniProt", "db_id": "O57672" }, { "db_name": "UniProt", "db_id": "O59494" }, { "db_name": "UniProt", "db_id": "O59841" }, { "db_name": "UniProt", "db_id": "O67161" }, { "db_name": "UniProt", "db_id": "O83816" }, { "db_name": "UniProt", "db_id": "O96423" }, { "db_name": "UniProt", "db_id": "P00355" }, { "db_name": "UniProt", "db_id": "P00356" }, { "db_name": "UniProt", "db_id": "P00357" }, { "db_name": "UniProt", "db_id": "P00361" }, { "db_name": "UniProt", "db_id": 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[ { "id": "DS.d1752.s0", "type": "", "text": [ "It is suggested that in this animal model, characterized by TSH elevation and low-grade inflammation, an increased expression and function of iNOS, resulting in superoxide generation, accounts for an impaired NO availability." ], "offsets": [ [ 0, 225 ] ] } ]

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[ { "id": "DS.d1754.s0", "type": "", "text": [ "Vernakalant was metabolized rapidly via 4-O-demethylation by cytochrome P450 (CYP)2D6 to its major metabolite RSD1385, which then circulated predominantly as an inactive glucuronide conjugate." ], "offsets": [ [ 0, 192 ] ] } ]

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[ { "id": "DS.d1755.s0", "type": "", "text": [ "We assessed in vivo carotid sinus nerve activity (CSNA) at baseline, in response to acute hypoxia, in response to infused NMDA, and in response to infused endothelin-1 (ET-1) with and without MK-801, an NMDA receptor blocker." ], "offsets": [ [ 0, 225 ] ] } ]

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[ { "id": "DS.d1756.s0", "type": "", "text": [ "Thus, CS-mediated down-regulation of HDAC2 in human macrophages and lung epithelial cells in vitro and in mouse lung in vivo involves the induction of serine/threonine phosphorylation and proteasomal degradation, which may have implications for steroid resistance and abnormal inflammation caused by cigarette smoke." ], "offsets": [ [ 0, 316 ] ] } ]

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[ { "id": "DS.d1757.s0", "type": "", "text": [ "Immunofluorescence microscopy of live human umbilical vein endothelial cells showed that VWF multimers rapidly formed strings several hundred micrometers long on the cell surface after stimulation with histamine." ], "offsets": [ [ 0, 212 ] ] }, { "id": "DS.d1757.s1", "type": "", "text": [ "Soluble P-selectin reduced the number of platelet-decorated VWF strings in the absence of Ca(2+) and Mg(2+) but had no effect in the presence of these cations." ], "offsets": [ [ 213, 372 ] ] } ]

[ { "id": "DS.d1757.s0.e0", "type": "protein", "text": [ "VWF" ], "offsets": [ [ 89, 92 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04275" }, { "db_name": "UniProt", "db_id": "P80012" }, { "db_name": "UniProt", "db_id": "Q28295" }, { "db_name": "UniProt", "db_id": "Q28833" }, { "db_name": "UniProt", "db_id": "Q8CIZ8" } ] }, { "id": "DS.d1757.s0.e1", "type": "compound", "text": [ "histamine" ], "offsets": [ [ 202, 211 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "774" } ] }, { "id": "DS.d1757.s1.e0", "type": "protein", "text": [ "VWF" ], "offsets": [ [ 273, 276 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P04275" }, { "db_name": "UniProt", "db_id": "P80012" }, { "db_name": "UniProt", "db_id": "Q28295" }, { "db_name": "UniProt", "db_id": "Q28833" }, { "db_name": "UniProt", "db_id": "Q8CIZ8" } ] }, { "id": "DS.d1757.s1.e1", "type": "compound", "text": [ "Ca(2" ], "offsets": [ [ 303, 307 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "271" } ] } ]

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[ { "id": "DS.d1758.s0", "type": "", "text": [ "To examine the relationship of functional expression of VLA-4 to prognosis in AML, we studied marrow samples from 175 adult AML patients who underwent induction chemotherapy with anthracycline and cytarabine on Southwest Oncology Group trials." ], "offsets": [ [ 0, 243 ] ] } ]

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[ { "id": "DS.d1759.s0", "type": "", "text": [ "Independent lines of research involving biochemical and behavioral approaches in normal and/or genetically modified mice provide converging evidence for an involvement of the signaling molecules Akt and glycogen synthase kinase-3 (GSK3) in the regulation of behavior by dopamine and serotonin (5-HT)." ], "offsets": [ [ 0, 300 ] ] } ]

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[ { "id": "DS.d1759.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1759.s0.e5", "arg2_id": "DS.d1759.s0.e2", "normalized": [] }, { "id": "DS.d1759.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1759.s0.e4", "arg2_id": "DS.d1759.s0.e0", "normalized": [] }, { "id": "DS.d1759.s0.i2", "type": "compound-protein-interaction", "arg1_id": "DS.d1759.s0.e4", "arg2_id": "DS.d1759.s0.e2", "normalized": [] }, { "id": "DS.d1759.s0.i3", "type": "compound-protein-interaction", "arg1_id": "DS.d1759.s0.e3", "arg2_id": "DS.d1759.s0.e0", "normalized": [] }, { "id": "DS.d1759.s0.i7", "type": "compound-protein-interaction", "arg1_id": "DS.d1759.s0.e3", "arg2_id": "DS.d1759.s0.e2", "normalized": [] }, { "id": "DS.d1759.s0.i8", "type": "compound-protein-interaction", "arg1_id": "DS.d1759.s0.e5", "arg2_id": "DS.d1759.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1760.s0", "type": "", "text": [ "Inhibition of GSK3beta by lithium in vivo suppressed the inflammatory response in mice infected with F. tularensis LVS and conferred a survival advantage." ], "offsets": [ [ 0, 154 ] ] } ]

[ { "id": "DS.d1760.s0.e0", "type": "protein", "text": [ "GSK3beta" ], "offsets": [ [ 14, 22 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P18266" }, { "db_name": "UniProt", "db_id": "P49841" }, { "db_name": "UniProt", "db_id": "Q5YJC2" }, { "db_name": "UniProt", "db_id": "Q9WV60" } ] }, { "id": "DS.d1760.s0.e1", "type": "compound", "text": [ "lithium" ], "offsets": [ [ 26, 33 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "28486" }, { "db_name": "PubChem", "db_id": "3028194" } ] } ]

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[ { "id": "DS.d1760.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1760.s0.e1", "arg2_id": "DS.d1760.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1761.s0", "type": "", "text": [ "The capacity for osmotic adjustment, superoxide dismutase (SOD) and ascorbate peroxidase (APX) activities and proline content were also elevated in the transgenic Arabidopsis plants." ], "offsets": [ [ 0, 182 ] ] } ]

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[ { "id": "DS.d1762.s0", "type": "", "text": [ "To prevent the effects of interfering anionic species, such as uric acid and ascorbic acid, on the sensor response, the Pt-Ir electrode was coated with Nafion, and then glucose oxidase was immobilized on the coated electrode." ], "offsets": [ [ 0, 225 ] ] } ]

[ { "id": "DS.d1762.s0.e0", "type": "compound", "text": [ "uric acid" ], "offsets": [ [ 63, 72 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "1175" } ] }, { "id": "DS.d1762.s0.e1", "type": "compound", "text": [ "ascorbic acid" ], "offsets": [ [ 77, 90 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "54670067" }, { "db_name": "PubChem", "db_id": "54690394" } ] }, { "id": "DS.d1762.s0.e2", "type": "compound", "text": [ "Nafion" ], "offsets": [ [ 152, 158 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "61890" } ] }, { "id": "DS.d1762.s0.e3", "type": "protein", "text": [ "glucose oxidase" ], "offsets": [ [ 169, 184 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "P81156" } ] } ]

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[ { "id": "DS.d1765.s0", "type": "", "text": [ "A naturally occurring glycine to aspartic acid mutation at position 169 (G169D) in the putative transmembrane domain 4 (TM4) makes mice susceptible to Salmonella typhimurim, Leishmania donovani, and Mycobacterium bovis." ], "offsets": [ [ 0, 219 ] ] } ]

[ { "id": "DS.d1765.s0.e0", "type": "compound", "text": [ "glycine" ], "offsets": [ [ 22, 29 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "750" } ] }, { "id": "DS.d1765.s0.e1", "type": "compound", "text": [ "aspartic acid" ], "offsets": [ [ 33, 46 ] ], "normalized": [ { "db_name": "PubChem", "db_id": "424" }, { "db_name": "PubChem", "db_id": "5960" }, { "db_name": "PubChem", "db_id": "83887" } ] }, { "id": "DS.d1765.s0.e2", "type": "protein", "text": [ "TM4" ], "offsets": [ [ 120, 123 ] ], "normalized": [ { "db_name": "UniProt", "db_id": "Q40170" } ] } ]

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[ { "id": "DS.d1765.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1765.s0.e1", "arg2_id": "DS.d1765.s0.e2", "normalized": [] }, { "id": "DS.d1765.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1765.s0.e0", "arg2_id": "DS.d1765.s0.e2", "normalized": [] } ]

[ { "id": "DS.d1766.s0", "type": "", "text": [ "Serum free L-carnitine in association with myoglobin as a diagnostic marker of acute myocardial infarction." ], "offsets": [ [ 0, 107 ] ] }, { "id": "DS.d1766.s1", "type": "", "text": [ "The aim of this study was to monitor the level of serum free L-carnitine in combination with myoglobin (Myo) and creatine kinase (total activity and CK-MB level) for usefulness as a predictor of AMI in ICU patients." ], "offsets": [ [ 108, 323 ] ] } ]

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[]

[]

[ { "id": "DS.d1766.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1766.s0.e0", "arg2_id": "DS.d1766.s0.e1", "normalized": [] } ]

[ { "id": "DS.d1767.s0", "type": "", "text": [ "Curcuminoids inhibited AChE in the in-vitro assay with IC(50) value of 19.67, bisdemethoxycurcumin 16.84, demethoxycurcumin 33.14 and curcumin 67.69 microM." ], "offsets": [ [ 0, 156 ] ] } ]

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[]

[]

[ { "id": "DS.d1767.s0.i1", "type": "compound-protein-interaction", "arg1_id": "DS.d1767.s0.e1", "arg2_id": "DS.d1767.s0.e0", "normalized": [] } ]

[ { "id": "DS.d1768.s0", "type": "", "text": [ "L-penetratin was the most effective promoter of insulin absorption compared with others CPPs." ], "offsets": [ [ 0, 93 ] ] }, { "id": "DS.d1768.s1", "type": "", "text": [ "A dose-dependent relationship of L-penetratin and insulin bioavailability was statically significant." ], "offsets": [ [ 94, 195 ] ] }, { "id": "DS.d1768.s2", "type": "", "text": [ "There was no significant difference in the release of LDH in nasal lavage fluid and the integrity of nasal respiratory epithelium when L-penetratin was present." ], "offsets": [ [ 196, 356 ] ] } ]

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[]

[]

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[ { "id": "DS.d1770.s0", "type": "", "text": [ "Osteoblasts up-regulate the expression of extracellular proteases following attachment to Poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate)." ], "offsets": [ [ 0, 141 ] ] } ]

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[]

[]

[ { "id": "DS.d1770.s0.i0", "type": "compound-protein-interaction", "arg1_id": "DS.d1770.s0.e1", "arg2_id": "DS.d1770.s0.e0", "normalized": [] } ]