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[ { "id": "NCT03247738_exc_text", "type": "exclusion", "text": [ "Inability to provide written informed consent\nKnown history of prior intracranial bleeding\nOn treatment with a P2Y12 receptor antagonist (ticlopidine, clopidogrel, prasugrel, ticagrelor) in the prior 10 days\nKnown allergies to aspirin, ticagrelor or cangrelor\nOn treatment with oral anticoagulant\nTreatment with glycoprotein IIb/IIIa inhibitors\nFibrinolytics within 24 hours\nActive bleeding\nHigh risk of bleeding\nKnown platelet count <80x106/mL\nKnown hemoglobin <10 g/dL\nIntubated patients (prior to randomization)\nKnown creatinine clearance <30 mL/minute or on hemodialysis.\nKnown severe hepatic dysfunction\nPatients with sick sinus syndrome (SSS) or high degree AV block without pacemaker protection\nCurrent treatment with drugs interfering with CYP3A4 metabolism (to avoid interaction with ticagrelor): Ketoconazole, itraconazole, voriconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, atazanavir, and telithromizycin.\nPregnant or lactating females.\n" ], "offsets": [ [ 0, 986 ] ] } ]

[ { "id": "NCT03247738_exc_T2", "type": "Condition", "text": [ "intracranial bleeding" ], "offsets": [ [ 69, 90 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T3", "type": "Qualifier", "text": [ "prior" ], "offsets": [ [ 63, 68 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T4", "type": "Drug", "text": [ "P2Y12 receptor antagonist" ], "offsets": [ [ 111, 136 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T5", "type": "Drug", "text": [ "ticlopidine" ], "offsets": [ [ 138, 149 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T6", "type": "Drug", "text": [ "clopidogrel" ], "offsets": [ [ 151, 162 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T7", "type": "Drug", "text": [ "prasugrel" ], "offsets": [ [ 164, 173 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T8", "type": "Drug", "text": [ "ticagrelor" ], "offsets": [ [ 175, 185 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T9", "type": "Scope", "text": [ "ticlopidine, clopidogrel, prasugrel, ticagrelor" ], "offsets": [ [ 138, 185 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T10", "type": "Temporal", "text": [ "prior 10 days" ], "offsets": [ [ 194, 207 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T11", "type": "Condition", "text": [ "allergies" ], "offsets": [ [ 214, 223 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T12", "type": "Drug", "text": [ "aspirin" ], "offsets": [ [ 227, 234 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T13", "type": "Drug", "text": [ "ticagrelor" ], "offsets": [ [ 236, 246 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T14", "type": "Drug", "text": [ "cangrelor" ], "offsets": [ [ 250, 259 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T15", "type": "Scope", "text": [ "aspirin, ticagrelor or cangrelor" ], "offsets": [ [ 227, 259 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T16", "type": "Drug", "text": [ "anticoagulant" ], "offsets": [ [ 283, 296 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T17", "type": "Qualifier", "text": [ "oral" ], "offsets": [ [ 278, 282 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T18", "type": "Drug", "text": [ "glycoprotein IIb/IIIa inhibitors" ], "offsets": [ [ 312, 344 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T19", "type": "Procedure", "text": [ "Fibrinolytics" ], "offsets": [ [ 345, 358 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T20", "type": "Temporal", "text": [ "within 24 hours" ], "offsets": [ [ 359, 374 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T21", "type": "Condition", "text": [ "Active bleeding" ], "offsets": [ [ 375, 390 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T22", "type": "Qualifier", "text": [ "High risk" ], "offsets": [ [ 391, 400 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T23", "type": "Condition", "text": [ "bleeding" ], "offsets": [ [ 404, 412 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T24", "type": "Measurement", "text": [ "platelet count" ], "offsets": [ [ 419, 433 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T25", "type": "Value", "text": [ "<80x106/mL" ], "offsets": [ [ 434, 444 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T26", "type": "Measurement", "text": [ "hemoglobin" ], "offsets": [ [ 451, 461 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T27", "type": "Value", "text": [ "<10 g/dL" ], "offsets": [ [ 462, 470 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T28", "type": "Condition", "text": [ "Intubated" ], "offsets": [ [ 471, 480 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T29", "type": "Temporal", "text": [ "prior to randomization" ], "offsets": [ [ 491, 513 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T30", "type": "Reference_point", "text": [ "randomization" ], "offsets": [ [ 500, 513 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T31", "type": "Measurement", "text": [ "creatinine clearance" ], "offsets": [ [ 521, 541 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T32", "type": "Value", "text": [ "<30 mL/minute" ], "offsets": [ [ 542, 555 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T33", "type": "Procedure", "text": [ "hemodialysis" ], "offsets": [ [ 562, 574 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T34", "type": "Condition", "text": [ "hepatic dysfunction" ], "offsets": [ [ 589, 608 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T35", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 582, 588 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T36", "type": "Condition", "text": [ "sick sinus syndrome" ], "offsets": [ [ 623, 642 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T37", "type": "Condition", "text": [ "SSS" ], "offsets": [ [ 644, 647 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T38", "type": "Condition", "text": [ "AV block" ], "offsets": [ [ 664, 672 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T39", "type": "Qualifier", "text": [ "high degree" ], "offsets": [ [ 652, 663 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T40", "type": "Procedure", "text": [ "pacemaker" ], "offsets": [ [ 681, 690 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T41", "type": "Negation", "text": [ "without" ], "offsets": [ [ 673, 680 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T42", "type": "Drug", "text": [ "drugs" ], "offsets": [ [ 725, 730 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T43", "type": "Condition", "text": [ "CYP3A4 metabolism" ], "offsets": [ [ 748, 765 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T44", "type": "Drug", "text": [ "ticagrelor" ], "offsets": [ [ 793, 803 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T45", "type": "Mood", "text": [ "interfering with" ], "offsets": [ [ 731, 747 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T46", "type": "Drug", "text": [ "Ketoconazole" ], "offsets": [ [ 806, 818 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T48", "type": "Drug", "text": [ "itraconazole" ], "offsets": [ [ 820, 832 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T49", "type": "Drug", "text": [ "voriconazole" ], "offsets": [ [ 834, 846 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T50", "type": "Drug", "text": [ "clarithromycin" ], "offsets": [ [ 848, 862 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T51", "type": "Drug", "text": [ "nefazodone" ], "offsets": [ [ 864, 874 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T52", "type": "Drug", "text": [ "ritonavir" ], "offsets": [ [ 876, 885 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T53", "type": "Drug", "text": [ "saquinavir" ], "offsets": [ [ 887, 897 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T54", "type": "Drug", "text": [ "nelfinavir" ], "offsets": [ [ 899, 909 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T55", "type": "Drug", "text": [ "indinavir" ], "offsets": [ [ 911, 920 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T56", "type": "Drug", "text": [ "atazanavir" ], "offsets": [ [ 922, 932 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T57", "type": "Drug", "text": [ "telithromizycin" ], "offsets": [ [ 938, 953 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T58", "type": "Scope", "text": [ "Ketoconazole, itraconazole, voriconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, atazanavir, and telithromizycin" ], "offsets": [ [ 806, 953 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T59", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 955, 963 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T60", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 967, 976 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T61", "type": "Person", "text": [ "females" ], "offsets": [ [ 977, 984 ] ], "normalized": [] }, { "id": "NCT03247738_exc_T62", "type": "Scope", "text": [ "Pregnant or lactating" ], "offsets": [ [ 955, 976 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03247738_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03247738_exc_T2", "arg2_id": "NCT03247738_exc_T3", "normalized": [] }, { "id": "NCT03247738_exc_R2", "type": "Subsumes", "arg1_id": "NCT03247738_exc_T4", "arg2_id": "NCT03247738_exc_T9", "normalized": [] }, { "id": "NCT03247738_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03247738_exc_T4", "arg2_id": "NCT03247738_exc_T10", "normalized": [] }, { "id": "NCT03247738_exc_R4", "type": "Has_scope", "arg1_id": "NCT03247738_exc_T11", "arg2_id": "NCT03247738_exc_T15", "normalized": [] }, { "id": "NCT03247738_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03247738_exc_T16", "arg2_id": "NCT03247738_exc_T17", "normalized": [] }, { "id": "NCT03247738_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03247738_exc_T19", "arg2_id": "NCT03247738_exc_T20", "normalized": [] }, { "id": "NCT03247738_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03247738_exc_T23", "arg2_id": "NCT03247738_exc_T22", "normalized": [] }, { "id": "NCT03247738_exc_R8", "type": "Has_value", "arg1_id": "NCT03247738_exc_T24", "arg2_id": "NCT03247738_exc_T25", "normalized": [] }, { "id": "NCT03247738_exc_R9", "type": "Has_value", "arg1_id": "NCT03247738_exc_T26", "arg2_id": "NCT03247738_exc_T27", "normalized": [] }, { "id": "NCT03247738_exc_R10", "type": "Has_index", "arg1_id": "NCT03247738_exc_T29", "arg2_id": "NCT03247738_exc_T30", "normalized": [] }, { "id": "NCT03247738_exc_R11", "type": "Has_temporal", "arg1_id": "NCT03247738_exc_T28", "arg2_id": "NCT03247738_exc_T29", "normalized": [] }, { "id": "NCT03247738_exc_R12", "type": "Has_value", "arg1_id": "NCT03247738_exc_T31", "arg2_id": "NCT03247738_exc_T32", "normalized": [] }, { "id": "NCT03247738_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT03247738_exc_T34", "arg2_id": "NCT03247738_exc_T35", "normalized": [] }, { "id": "NCT03247738_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT03247738_exc_T38", "arg2_id": "NCT03247738_exc_T39", "normalized": [] }, { "id": "NCT03247738_exc_R15", "type": "Has_negation", "arg1_id": "NCT03247738_exc_T40", "arg2_id": "NCT03247738_exc_T41", "normalized": [] }, { "id": "NCT03247738_exc_R16", "type": "AND", "arg1_id": "NCT03247738_exc_T38", "arg2_id": "NCT03247738_exc_T40", "normalized": [] }, { "id": "NCT03247738_exc_R17", "type": "Subsumes", "arg1_id": "NCT03247738_exc_T36", "arg2_id": "NCT03247738_exc_T37", "normalized": [] }, { "id": "NCT03247738_exc_R18", "type": "AND", "arg1_id": "NCT03247738_exc_T42", "arg2_id": "NCT03247738_exc_T43", "normalized": [] }, { "id": "NCT03247738_exc_R19", "type": "Has_mood", "arg1_id": "NCT03247738_exc_T43", "arg2_id": "NCT03247738_exc_T45", "normalized": [] }, { "id": "NCT03247738_exc_R20", "type": "Subsumes", "arg1_id": "NCT03247738_exc_T42", "arg2_id": "NCT03247738_exc_T58", "normalized": [] }, { "id": "NCT03247738_exc_R21", "type": "Has_scope", "arg1_id": "NCT03247738_exc_T61", "arg2_id": "NCT03247738_exc_T62", "normalized": [] } ]

[ { "id": "NCT03247738_inc_text", "type": "inclusion", "text": [ "Patients with STEMI undergoing primary PPCI\nAge > 18 years old\n" ], "offsets": [ [ 0, 63 ] ] } ]

[ { "id": "NCT03247738_inc_T1", "type": "Condition", "text": [ "STEMI" ], "offsets": [ [ 14, 19 ] ], "normalized": [] }, { "id": "NCT03247738_inc_T2", "type": "Procedure", "text": [ "primary PPCI" ], "offsets": [ [ 31, 43 ] ], "normalized": [] }, { "id": "NCT03247738_inc_T3", "type": "Person", "text": [ "Age" ], "offsets": [ [ 44, 47 ] ], "normalized": [] }, { "id": "NCT03247738_inc_T4", "type": "Value", "text": [ "> 18 years old" ], "offsets": [ [ 48, 62 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03247738_inc_R1", "type": "AND", "arg1_id": "NCT03247738_inc_T1", "arg2_id": "NCT03247738_inc_T2", "normalized": [] }, { "id": "NCT03247738_inc_R2", "type": "Has_value", "arg1_id": "NCT03247738_inc_T3", "arg2_id": "NCT03247738_inc_T4", "normalized": [] } ]

[ { "id": "NCT03249272_exc_text", "type": "exclusion", "text": [ "Decompensated heart failure or hemodynamic instability\nPrior coronary revascularization (PCI or CABG) or myocardial infarction (as evidenced by previously elevated CPK-MB or troponin levels)\nAccelerating angina or unstable angina\nInability to physically tolerate MRI or implanted objects that are MRI incompatible\nInability to provide written informed consent obtained at time of study enrollment.\nSevere claustrophobia\nAdvanced heart block or sinus node dysfunction\nHypersensitivity or allergic reaction to regadenoson or adenosine\nHypotension\nActive bronchospasm or history of hospitalization due to bronchospasm\nHistory of seizures\nRecent cerebrovascular accident\nUse of dipyridamole within the last 5 days\nContraindication to aminophylline\nSevere renal insufficiency with estimated glomerular filtration rate <30 ml/min/ 1.73 m2\nPregnant or nursing\n" ], "offsets": [ [ 0, 853 ] ] } ]

[ { "id": "NCT03249272_exc_T1", "type": "Qualifier", "text": [ "Decompensated" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T2", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 14, 27 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T3", "type": "Condition", "text": [ "hemodynamic instability" ], "offsets": [ [ 31, 54 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T4", "type": "Temporal", "text": [ "Prior" ], "offsets": [ [ 55, 60 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T5", "type": "Condition", "text": [ "coronary revascularization" ], "offsets": [ [ 61, 87 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T6", "type": "Procedure", "text": [ "PCI" ], "offsets": [ [ 89, 92 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T7", "type": "Procedure", "text": [ "CABG" ], "offsets": [ [ 96, 100 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T8", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 105, 126 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T9", "type": "Measurement", "text": [ "PK-MB", "evels)" ], "offsets": [ [ 165, 170 ], [ 184, 190 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T10", "type": "Measurement", "text": [ "troponin levels" ], "offsets": [ [ 174, 189 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T11", "type": "Scope", "text": [ "CPK-MB or troponin levels" ], "offsets": [ [ 164, 189 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T12", "type": "Value", "text": [ "elevated" ], "offsets": [ [ 155, 163 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T13", "type": "Temporal", "text": [ "previously" ], "offsets": [ [ 144, 154 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T14", "type": "Scope", "text": [ "previously elevated CPK-MB or troponin levels" ], "offsets": [ [ 144, 189 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T15", "type": "Scope", "text": [ "PCI or CABG" ], "offsets": [ [ 89, 100 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T16", "type": "Condition", "text": [ "Accelerating angina" ], "offsets": [ [ 191, 210 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T17", "type": "Condition", "text": [ "unstable angina" ], "offsets": [ [ 214, 229 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T18", "type": "Condition", "text": [ "Inability to physically tolerate" ], "offsets": [ [ 230, 262 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T19", "type": "Procedure", "text": [ "MRI" ], "offsets": [ [ 263, 266 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T20", "type": "Device", "text": [ "implanted objects" ], "offsets": [ [ 270, 287 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T21", "type": "Qualifier", "text": [ "MRI incompatible" ], "offsets": [ [ 297, 313 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T22", "type": "Scope", "text": [ "MRI or implanted objects that are MRI incompatible" ], "offsets": [ [ 263, 313 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T24", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 398, 404 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T25", "type": "Condition", "text": [ "claustrophobia" ], "offsets": [ [ 405, 419 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T26", "type": "Condition", "text": [ "sinus node dysfunction" ], "offsets": [ [ 444, 466 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T27", "type": "Condition", "text": [ "heart block" ], "offsets": [ [ 429, 440 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T28", "type": "Qualifier", "text": [ "Advanced" ], "offsets": [ [ 420, 428 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T29", "type": "Scope", "text": [ "heart block or sinus node dysfunction" ], "offsets": [ [ 429, 466 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T30", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 467, 483 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T31", "type": "Condition", "text": [ "allergic" ], "offsets": [ [ 487, 495 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T32", "type": "Drug", "text": [ "regadenoson" ], "offsets": [ [ 508, 519 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T33", "type": "Drug", "text": [ "adenosine" ], "offsets": [ [ 523, 532 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T34", "type": "Scope", "text": [ "regadenoson or adenosine" ], "offsets": [ [ 508, 532 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T35", "type": "Scope", "text": [ "Hypersensitivity or allergic" ], "offsets": [ [ 467, 495 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T36", "type": "Condition", "text": [ "Hypotension" ], "offsets": [ [ 533, 544 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T37", "type": "Qualifier", "text": [ "Active" ], "offsets": [ [ 545, 551 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T38", "type": "Condition", "text": [ "bronchospasm" ], "offsets": [ [ 552, 564 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T39", "type": "Observation", "text": [ "history" ], "offsets": [ [ 568, 575 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T40", "type": "Procedure", "text": [ "hospitalization" ], "offsets": [ [ 579, 594 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T41", "type": "Condition", "text": [ "bronchospasm" ], "offsets": [ [ 602, 614 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T42", "type": "Observation", "text": [ "History" ], "offsets": [ [ 615, 622 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T43", "type": "Condition", "text": [ "seizures" ], "offsets": [ [ 626, 634 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T44", "type": "Temporal", "text": [ "Recent" ], "offsets": [ [ 635, 641 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T45", "type": "Condition", "text": [ "cerebrovascular accident" ], "offsets": [ [ 642, 666 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T46", "type": "Drug", "text": [ "dipyridamole" ], "offsets": [ [ 674, 686 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T47", "type": "Temporal", "text": [ "within the last 5 days" ], "offsets": [ [ 687, 709 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T48", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 710, 726 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T49", "type": "Drug", "text": [ "aminophylline" ], "offsets": [ [ 730, 743 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T50", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 744, 750 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T51", "type": "Condition", "text": [ "renal insufficiency" ], "offsets": [ [ 751, 770 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T52", "type": "Measurement", "text": [ "estimated glomerular filtration rate" ], "offsets": [ [ 776, 812 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T53", "type": "Value", "text": [ "<30 ml/min/ 1.73 m2" ], "offsets": [ [ 813, 832 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T54", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 833, 841 ] ], "normalized": [] }, { "id": "NCT03249272_exc_T55", "type": "Condition", "text": [ "nursing" ], "offsets": [ [ 845, 852 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03249272_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03249272_exc_T2", "arg2_id": "NCT03249272_exc_T1", "normalized": [] }, { "id": "NCT03249272_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03249272_exc_T11", "arg2_id": "NCT03249272_exc_T13", "normalized": [] }, { "id": "NCT03249272_exc_R3", "type": "Has_value", "arg1_id": "NCT03249272_exc_T11", "arg2_id": "NCT03249272_exc_T12", "normalized": [] }, { "id": "NCT03249272_exc_R4", "type": "Subsumes", "arg1_id": "NCT03249272_exc_T8", "arg2_id": "NCT03249272_exc_T14", "normalized": [] }, { "id": "NCT03249272_exc_R5", "type": "Subsumes", "arg1_id": "NCT03249272_exc_T5", "arg2_id": "NCT03249272_exc_T15", "normalized": [] }, { "id": "NCT03249272_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03249272_exc_T5", "arg2_id": "NCT03249272_exc_T4", "normalized": [] }, { "id": "NCT03249272_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03249272_exc_T8", "arg2_id": "NCT03249272_exc_T4", "normalized": [] }, { "id": "NCT03249272_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03249272_exc_T20", "arg2_id": "NCT03249272_exc_T21", "normalized": [] }, { "id": "NCT03249272_exc_R9", "type": "Has_scope", "arg1_id": "NCT03249272_exc_T18", "arg2_id": "NCT03249272_exc_T22", "normalized": [] }, { "id": "NCT03249272_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03249272_exc_T25", "arg2_id": "NCT03249272_exc_T24", "normalized": [] }, { "id": "NCT03249272_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT03249272_exc_T29", "arg2_id": "NCT03249272_exc_T28", "normalized": [] }, { "id": "NCT03249272_exc_R12", "type": "Has_scope", "arg1_id": "NCT03249272_exc_T35", "arg2_id": "NCT03249272_exc_T34", "normalized": [] }, { "id": "NCT03249272_exc_R13", "type": "AND", "arg1_id": "NCT03249272_exc_T40", "arg2_id": "NCT03249272_exc_T41", "normalized": [] }, { "id": "NCT03249272_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03249272_exc_T40", "arg2_id": "NCT03249272_exc_T39", "normalized": [] }, { "id": "NCT03249272_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT03249272_exc_T38", "arg2_id": "NCT03249272_exc_T37", "normalized": [] }, { "id": "NCT03249272_exc_R16", "type": "Has_temporal", "arg1_id": "NCT03249272_exc_T43", "arg2_id": "NCT03249272_exc_T42", "normalized": [] }, { "id": "NCT03249272_exc_R17", "type": "Has_temporal", "arg1_id": "NCT03249272_exc_T45", "arg2_id": "NCT03249272_exc_T44", "normalized": [] }, { "id": "NCT03249272_exc_R18", "type": "Has_temporal", "arg1_id": "NCT03249272_exc_T46", "arg2_id": "NCT03249272_exc_T47", "normalized": [] }, { "id": "NCT03249272_exc_R19", "type": "AND", "arg1_id": "NCT03249272_exc_T48", "arg2_id": "NCT03249272_exc_T49", "normalized": [] }, { "id": "NCT03249272_exc_R20", "type": "Has_value", "arg1_id": "NCT03249272_exc_T52", "arg2_id": "NCT03249272_exc_T53", "normalized": [] }, { "id": "NCT03249272_exc_R21", "type": "Has_qualifier", "arg1_id": "NCT03249272_exc_T51", "arg2_id": "NCT03249272_exc_T50", "normalized": [] }, { "id": "NCT03249272_exc_R22", "type": "AND", "arg1_id": "NCT03249272_exc_T51", "arg2_id": "NCT03249272_exc_T52", "normalized": [] } ]

[ { "id": "NCT03249272_inc_text", "type": "inclusion", "text": [ "Men or women aged 18 years or older\nPatients presenting for CMR with the clinical diagnosis of hypertrophic cardiomyopathy based on left ventricular wall thickness of at least =15 mm in the absence of any other cardiac or systemic cause of hypertrophy\nPatients presenting for CMR with the clinical diagnosis of idiopathic dilated cardiomyopathy based upon left ventricular ejection fraction =40%, LV end-diastolic diameter =55 mm or left ventricular end-systolic diameter =45 mm, and the absence of coronary stenoses on angiography.\nPatients presenting for CMR evaluation of chest pain but without evidence of obstructive coronary artery disease either by coronary angiography or stress testing.\n" ], "offsets": [ [ 0, 696 ] ] } ]

[ { "id": "NCT03249272_inc_T1", "type": "Person", "text": [ "Men" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T2", "type": "Person", "text": [ "women" ], "offsets": [ [ 7, 12 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T3", "type": "Person", "text": [ "aged" ], "offsets": [ [ 13, 17 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T4", "type": "Value", "text": [ "18 years or older" ], "offsets": [ [ 18, 35 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T6", "type": "Condition", "text": [ "hypertrophic cardiomyopathy" ], "offsets": [ [ 95, 122 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T7", "type": "Measurement", "text": [ "left ventricular wall thickness" ], "offsets": [ [ 132, 163 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T8", "type": "Value", "text": [ "at least =15 mm" ], "offsets": [ [ 167, 182 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T9", "type": "Negation", "text": [ "absence" ], "offsets": [ [ 190, 197 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T10", "type": "Condition", "text": [ "systemic cause of hypertrophy" ], "offsets": [ [ 222, 251 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T11", "type": "Condition", "text": [ "ardiac", "ause of hypertrophy" ], "offsets": [ [ 212, 218 ], [ 232, 251 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T12", "type": "Scope", "text": [ "cardiac or systemic cause of hypertrophy" ], "offsets": [ [ 211, 251 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T5", "type": "Condition", "text": [ "idiopathic dilated cardiomyopathy" ], "offsets": [ [ 311, 344 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T13", "type": "Measurement", "text": [ "left ventricular ejection fraction" ], "offsets": [ [ 356, 390 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T14", "type": "Value", "text": [ "=40%" ], "offsets": [ [ 391, 395 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T15", "type": "Measurement", "text": [ "LV end-diastolic diameter" ], "offsets": [ [ 397, 422 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T16", "type": "Value", "text": [ "=55 mm" ], "offsets": [ [ 423, 429 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T17", "type": "Measurement", "text": [ "left ventricular end-systolic diameter" ], "offsets": [ [ 433, 471 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T18", "type": "Value", "text": [ "=45 mm" ], "offsets": [ [ 472, 478 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T19", "type": "Negation", "text": [ "absence" ], "offsets": [ [ 488, 495 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T20", "type": "Condition", "text": [ "coronary stenoses" ], "offsets": [ [ 499, 516 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T21", "type": "Procedure", "text": [ "angiography" ], "offsets": [ [ 520, 531 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T22", "type": "Scope", "text": [ "left ventricular ejection fraction =40%, LV end-diastolic diameter =55 mm or left ventricular end-systolic diameter =45 mm" ], "offsets": [ [ 356, 478 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T23", "type": "Condition", "text": [ "chest pain" ], "offsets": [ [ 575, 585 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T24", "type": "Negation", "text": [ "without" ], "offsets": [ [ 590, 597 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T25", "type": "Condition", "text": [ "obstructive coronary artery disease" ], "offsets": [ [ 610, 645 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T26", "type": "Procedure", "text": [ "coronary angiography" ], "offsets": [ [ 656, 676 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T27", "type": "Procedure", "text": [ "stress testing" ], "offsets": [ [ 680, 694 ] ], "normalized": [] }, { "id": "NCT03249272_inc_T28", "type": "Scope", "text": [ "coronary angiography or stress testing" ], "offsets": [ [ 656, 694 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03249272_inc_R1", "type": "Has_value", "arg1_id": "NCT03249272_inc_T3", "arg2_id": "NCT03249272_inc_T4", "normalized": [] }, { "id": "NCT03249272_inc_R2", "type": "Has_negation", "arg1_id": "NCT03249272_inc_T12", "arg2_id": "NCT03249272_inc_T9", "normalized": [] }, { "id": "NCT03249272_inc_R3", "type": "Has_value", "arg1_id": "NCT03249272_inc_T7", "arg2_id": "NCT03249272_inc_T8", "normalized": [] }, { "id": "NCT03249272_inc_R4", "type": "Has_scope", "arg1_id": "NCT03249272_inc_T6", "arg2_id": "NCT03249272_inc_T12", "normalized": [] }, { "id": "NCT03249272_inc_R5", "type": "AND", "arg1_id": "NCT03249272_inc_T6", "arg2_id": "NCT03249272_inc_T7", "normalized": [] }, { "id": "NCT03249272_inc_R6", "type": "Has_value", "arg1_id": "NCT03249272_inc_T13", "arg2_id": "NCT03249272_inc_T14", "normalized": [] }, { "id": "NCT03249272_inc_R7", "type": "Has_negation", "arg1_id": "NCT03249272_inc_T20", "arg2_id": "NCT03249272_inc_T19", "normalized": [] }, { "id": "NCT03249272_inc_R8", "type": "AND", "arg1_id": "NCT03249272_inc_T21", "arg2_id": "NCT03249272_inc_T20", "normalized": [] }, { "id": "NCT03249272_inc_R9", "type": "Has_value", "arg1_id": "NCT03249272_inc_T17", "arg2_id": "NCT03249272_inc_T18", "normalized": [] }, { "id": "NCT03249272_inc_R10", "type": "Has_value", "arg1_id": "NCT03249272_inc_T15", "arg2_id": "NCT03249272_inc_T16", "normalized": [] }, { "id": "NCT03249272_inc_R11", "type": "AND", "arg1_id": "NCT03249272_inc_T5", "arg2_id": "NCT03249272_inc_T21", "normalized": [] }, { "id": "NCT03249272_inc_R12", "type": "Has_scope", "arg1_id": "NCT03249272_inc_T5", "arg2_id": "NCT03249272_inc_T22", "normalized": [] }, { "id": "NCT03249272_inc_R13", "type": "Has_scope", "arg1_id": "NCT03249272_inc_T25", "arg2_id": "NCT03249272_inc_T28", "normalized": [] }, { "id": "NCT03249272_inc_R14", "type": "Has_negation", "arg1_id": "NCT03249272_inc_T25", "arg2_id": "NCT03249272_inc_T24", "normalized": [] }, { "id": "NCT03249272_inc_R15", "type": "AND", "arg1_id": "NCT03249272_inc_T23", "arg2_id": "NCT03249272_inc_T25", "normalized": [] } ]

[ { "id": "NCT03249311_exc_text", "type": "exclusion", "text": [ "Lifetime personal history of diagnosis of major depressive disorder according to the DSM-V (American Psychiatric Association, 2013) using the Structured Clinical Interview for DSM-V Axis I Disorders, Research Version, Non-patient Edition (SCID-5-RV for DSM-V; First et al., 2015)\nA history of suicidal ideation and behaviour, including self-harm and/or harm to others.\nA history of substance abuse and/or dependence.\nA positive drug screen for illicit drugs\nSubstantial alcohol use\nCurrent use of Monoamine Oxidase Inhibitors (MAOIs), including the antibiotic linezolid and the thiazine dye methylthioninium chloride (methylene blue)\nCurrent use of serotonin-precursors (such as L-tryptophan, oxitriptan)\nCurrent use of serotonergic drugs (triptans, certain tricyclic antidepressants, lithium, tramadol, St. John's Wort)\nConcomitant use of NSAIDS, ASA, and other anticoagulants.\nCurrent use of Thioridazine\nCurrent use of CYP1A2 Inhibitors\nCurrent use of Triptans (5HT1 Agonists)\nBlood pressure greater than 140/90 and/or a pulse rate greater than 90 bpm\nRecent history of myocardial infarction, cerebrovascular accident, cardiac arrhythmias, or unstable heart disease.\nEvidence of significant physical illness contraindicating the use of levomilnacipran and duloxetine found on the physical exam or in the laboratory data obtained during the first week of the study\nCurrent use of medication that may affect voiding (ie- anticholinergics)\nHistory of obstructive urinary disorders and dysuria, prostatic hypertrophy, prostatitis, and other lower urinary tract obstructive disorders.\nHistory of Stevens-Johnson Syndrome and Erythema multiforme.\nDiabetes Type I and II\nFructose intolerance, glucose-galactose malabsorption or sucrose-isomaltase insufficiency.\nHepatic Impairment\nUncontrolled narrow-angle glaucoma\nSevere renal impairment\nHistory of seizure disorder\nAnatomically narrow ocular angles.\nOsteoporosis or major risk for bone fractures.\n" ], "offsets": [ [ 0, 1946 ] ] } ]

[ { "id": "NCT03249311_exc_T1", "type": "Condition", "text": [ "major depressive disorder" ], "offsets": [ [ 42, 67 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T2", "type": "Qualifier", "text": [ "DSM-V" ], "offsets": [ [ 85, 90 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T3", "type": "Procedure", "text": [ "Structured Clinical Interview for DSM-V Axis I Disorders, Research Version, Non-patient Edition" ], "offsets": [ [ 142, 237 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T4", "type": "Condition", "text": [ "suicidal ideation" ], "offsets": [ [ 293, 310 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T5", "type": "Condition", "text": [ "uicidal", "ehaviour," ], "offsets": [ [ 294, 301 ], [ 316, 325 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T6", "type": "Condition", "text": [ "self-harm" ], "offsets": [ [ 336, 345 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T7", "type": "Condition", "text": [ "harm to others" ], "offsets": [ [ 353, 367 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T8", "type": "Condition", "text": [ "substance abuse" ], "offsets": [ [ 382, 397 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T9", "type": "Condition", "text": [ "bstance a", "pendence." ], "offsets": [ [ 384, 393 ], [ 407, 416 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T10", "type": "Procedure", "text": [ "drug screen for illicit drugs" ], "offsets": [ [ 428, 457 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T11", "type": "Value", "text": [ "positive" ], "offsets": [ [ 419, 427 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T12", "type": "Condition", "text": [ "Substantial alcohol use" ], "offsets": [ [ 458, 481 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T13", "type": "Drug", "text": [ "Monoamine Oxidase Inhibitors (MAOIs)" ], "offsets": [ [ 497, 533 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T14", "type": "Drug", "text": [ "antibiotic linezolid" ], "offsets": [ [ 549, 569 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T15", "type": "Drug", "text": [ "thiazine dye" ], "offsets": [ [ 578, 590 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T16", "type": "Drug", "text": [ "methylthioninium chloride" ], "offsets": [ [ 591, 616 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T17", "type": "Drug", "text": [ "methylene blue" ], "offsets": [ [ 618, 632 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T18", "type": "Scope", "text": [ "antibiotic linezolid and the thiazine dye methylthioninium chloride (methylene blue)" ], "offsets": [ [ 549, 633 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T19", "type": "Drug", "text": [ "serotonin-precursors" ], "offsets": [ [ 649, 669 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T20", "type": "Drug", "text": [ "L-tryptophan" ], "offsets": [ [ 679, 691 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T21", "type": "Drug", "text": [ "oxitriptan" ], "offsets": [ [ 693, 703 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T22", "type": "Scope", "text": [ "L-tryptophan, oxitriptan" ], "offsets": [ [ 679, 703 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T23", "type": "Drug", "text": [ "serotonergic drugs" ], "offsets": [ [ 720, 738 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T24", "type": "Drug", "text": [ "triptans" ], "offsets": [ [ 740, 748 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T25", "type": "Drug", "text": [ "tricyclic antidepressant" ], "offsets": [ [ 758, 782 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T26", "type": "Drug", "text": [ "lithium" ], "offsets": [ [ 785, 792 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T27", "type": "Drug", "text": [ "tramadol" ], "offsets": [ [ 794, 802 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T28", "type": "Drug", "text": [ "St. John's Wort" ], "offsets": [ [ 804, 819 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T29", "type": "Scope", "text": [ "triptans, certain tricyclic antidepressants, lithium, tramadol, St. John's Wort" ], "offsets": [ [ 740, 819 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T30", "type": "Drug", "text": [ "NSAIDS" ], "offsets": [ [ 840, 846 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T31", "type": "Drug", "text": [ "ASA" ], "offsets": [ [ 848, 851 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T32", "type": "Drug", "text": [ "anticoagulants" ], "offsets": [ [ 863, 877 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T33", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 857, 862 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T34", "type": "Drug", "text": [ "Thioridazine" ], "offsets": [ [ 894, 906 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T35", "type": "Temporal", "text": [ "Concomitant" ], "offsets": [ [ 821, 832 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T36", "type": "Scope", "text": [ "NSAIDS, ASA, and other anticoagulants" ], "offsets": [ [ 840, 877 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T37", "type": "Drug", "text": [ "CYP1A2 Inhibitors" ], "offsets": [ [ 922, 939 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T38", "type": "Drug", "text": [ "Triptans" ], "offsets": [ [ 955, 963 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T39", "type": "Drug", "text": [ "5HT1 Agonists" ], "offsets": [ [ 965, 978 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T40", "type": "Measurement", "text": [ "Blood pressure" ], "offsets": [ [ 980, 994 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T41", "type": "Value", "text": [ "greater than 140/90" ], "offsets": [ [ 995, 1014 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T42", "type": "Measurement", "text": [ "pulse rate" ], "offsets": [ [ 1024, 1034 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T43", "type": "Value", "text": [ "greater than 90 bpm" ], "offsets": [ [ 1035, 1054 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T44", "type": "Temporal", "text": [ "Recent" ], "offsets": [ [ 1055, 1061 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T45", "type": "Observation", "text": [ "history" ], "offsets": [ [ 1062, 1069 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T46", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 1073, 1094 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T47", "type": "Condition", "text": [ "cerebrovascular accident" ], "offsets": [ [ 1096, 1120 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T48", "type": "Condition", "text": [ "cardiac arrhythmias" ], "offsets": [ [ 1122, 1141 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T49", "type": "Condition", "text": [ "unstable heart disease" ], "offsets": [ [ 1146, 1168 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T50", "type": "Scope", "text": [ "myocardial infarction, cerebrovascular accident, cardiac arrhythmias, or unstable heart disease" ], "offsets": [ [ 1073, 1168 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T51", "type": "Condition", "text": [ "physical illness" ], "offsets": [ [ 1194, 1210 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T52", "type": "Condition", "text": [ "contraindicating" ], "offsets": [ [ 1211, 1227 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T53", "type": "Drug", "text": [ "levomilnacipran" ], "offsets": [ [ 1239, 1254 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T54", "type": "Drug", "text": [ "duloxetine" ], "offsets": [ [ 1259, 1269 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T55", "type": "Procedure", "text": [ "physical exam" ], "offsets": [ [ 1283, 1296 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T56", "type": "Procedure", "text": [ "laboratory" ], "offsets": [ [ 1307, 1317 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T57", "type": "Temporal", "text": [ "during the first week of the study" ], "offsets": [ [ 1332, 1366 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T58", "type": "Scope", "text": [ "physical exam or in the laboratory" ], "offsets": [ [ 1283, 1317 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T59", "type": "Scope", "text": [ "levomilnacipran and duloxetine" ], "offsets": [ [ 1239, 1269 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T60", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 1382, 1392 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T61", "type": "Drug", "text": [ "anticholinergics" ], "offsets": [ [ 1422, 1438 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T62", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 1367, 1374 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T63", "type": "Condition", "text": [ "affect voiding" ], "offsets": [ [ 1402, 1416 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T64", "type": "Condition", "text": [ "obstructive urinary disorders" ], "offsets": [ [ 1451, 1480 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T65", "type": "Condition", "text": [ "dysuria" ], "offsets": [ [ 1485, 1492 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T66", "type": "Condition", "text": [ "prostatic hypertrophy" ], "offsets": [ [ 1494, 1515 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T67", "type": "Condition", "text": [ "prostatitis" ], "offsets": [ [ 1517, 1528 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T68", "type": "Condition", "text": [ "lower urinary tract obstructive disorders" ], "offsets": [ [ 1540, 1581 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T69", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 1534, 1539 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T70", "type": "Observation", "text": [ "History" ], "offsets": [ [ 1440, 1447 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T71", "type": "Scope", "text": [ "obstructive urinary disorders and dysuria, prostatic hypertrophy, prostatitis, and other lower urinary tract obstructive disorders" ], "offsets": [ [ 1451, 1581 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T72", "type": "Condition", "text": [ "Stevens-Johnson Syndrome" ], "offsets": [ [ 1594, 1618 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T73", "type": "Condition", "text": [ "Erythema multiforme" ], "offsets": [ [ 1623, 1642 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T74", "type": "Condition", "text": [ "Diabetes Type I" ], "offsets": [ [ 1644, 1659 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T75", "type": "Condition", "text": [ "d II\nFructose", "ra" ], "offsets": [ [ 1662, 1675 ], [ 1682, 1684 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T76", "type": "Condition", "text": [ "Fructose intolerance" ], "offsets": [ [ 1667, 1687 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T77", "type": "Condition", "text": [ "glucose-galactose malabsorption" ], "offsets": [ [ 1689, 1720 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T78", "type": "Condition", "text": [ "sucrose-isomaltase insufficiency" ], "offsets": [ [ 1724, 1756 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T79", "type": "Condition", "text": [ "Hepatic Impairment" ], "offsets": [ [ 1758, 1776 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T80", "type": "Condition", "text": [ "narrow-angle glaucoma" ], "offsets": [ [ 1790, 1811 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T81", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 1777, 1789 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T82", "type": "Condition", "text": [ "renal impairment" ], "offsets": [ [ 1819, 1835 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T83", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 1812, 1818 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T84", "type": "Condition", "text": [ "seizure disorder" ], "offsets": [ [ 1847, 1863 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T85", "type": "Observation", "text": [ "History" ], "offsets": [ [ 1836, 1843 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T86", "type": "Condition", "text": [ "Anatomically narrow ocular angles" ], "offsets": [ [ 1864, 1897 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T87", "type": "Condition", "text": [ "Osteoporosis" ], "offsets": [ [ 1899, 1911 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T88", "type": "Mood", "text": [ "major risk" ], "offsets": [ [ 1915, 1925 ] ], "normalized": [] }, { "id": "NCT03249311_exc_T89", "type": "Condition", "text": [ "bone fractures" ], "offsets": [ [ 1930, 1944 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03249311_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03249311_exc_T1", "arg2_id": "NCT03249311_exc_T2", "normalized": [] }, { "id": "NCT03249311_exc_R2", "type": "AND", "arg1_id": "NCT03249311_exc_T1", "arg2_id": "NCT03249311_exc_T3", "normalized": [] }, { "id": "NCT03249311_exc_R3", "type": "Has_value", "arg1_id": "NCT03249311_exc_T10", "arg2_id": "NCT03249311_exc_T11", "normalized": [] }, { "id": "NCT03249311_exc_R4", "type": "Subsumes", "arg1_id": "NCT03249311_exc_T15", "arg2_id": "NCT03249311_exc_T16", "normalized": [] }, { "id": "NCT03249311_exc_R5", "type": "Subsumes", "arg1_id": "NCT03249311_exc_T16", "arg2_id": "NCT03249311_exc_T17", "normalized": [] }, { "id": "NCT03249311_exc_R6", "type": "Subsumes", "arg1_id": "NCT03249311_exc_T13", "arg2_id": "NCT03249311_exc_T18", "normalized": [] }, { "id": "NCT03249311_exc_R7", "type": "Subsumes", "arg1_id": "NCT03249311_exc_T19", "arg2_id": "NCT03249311_exc_T22", "normalized": [] }, { "id": "NCT03249311_exc_R8", "type": "Subsumes", "arg1_id": "NCT03249311_exc_T23", "arg2_id": "NCT03249311_exc_T29", "normalized": [] }, { "id": "NCT03249311_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03249311_exc_T32", "arg2_id": "NCT03249311_exc_T33", "normalized": [] }, { "id": "NCT03249311_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03249311_exc_T36", "arg2_id": "NCT03249311_exc_T35", "normalized": [] }, { "id": "NCT03249311_exc_R11", "type": "Subsumes", "arg1_id": "NCT03249311_exc_T38", "arg2_id": "NCT03249311_exc_T39", "normalized": [] }, { "id": "NCT03249311_exc_R12", "type": "Has_value", "arg1_id": "NCT03249311_exc_T42", "arg2_id": "NCT03249311_exc_T43", "normalized": [] }, { "id": "NCT03249311_exc_R13", "type": "Has_value", "arg1_id": "NCT03249311_exc_T40", "arg2_id": "NCT03249311_exc_T41", "normalized": [] }, { "id": "NCT03249311_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03249311_exc_T45", "arg2_id": "NCT03249311_exc_T44", "normalized": [] }, { "id": "NCT03249311_exc_R15", "type": "Has_temporal", "arg1_id": "NCT03249311_exc_T50", "arg2_id": "NCT03249311_exc_T45", "normalized": [] }, { "id": "NCT03249311_exc_R16", "type": "AND", "arg1_id": "NCT03249311_exc_T51", "arg2_id": "NCT03249311_exc_T52", "normalized": [] }, { "id": "NCT03249311_exc_R17", "type": "Has_scope", "arg1_id": "NCT03249311_exc_T52", "arg2_id": "NCT03249311_exc_T59", "normalized": [] }, { "id": "NCT03249311_exc_R18", "type": "Has_scope", "arg1_id": "NCT03249311_exc_T51", "arg2_id": "NCT03249311_exc_T58", "normalized": [] }, { "id": "NCT03249311_exc_R19", "type": "Has_temporal", "arg1_id": "NCT03249311_exc_T58", "arg2_id": "NCT03249311_exc_T57", "normalized": [] }, { "id": "NCT03249311_exc_R20", "type": "Has_temporal", "arg1_id": "NCT03249311_exc_T60", "arg2_id": "NCT03249311_exc_T62", "normalized": [] }, { "id": "NCT03249311_exc_R21", "type": "Subsumes", "arg1_id": "NCT03249311_exc_T60", "arg2_id": "NCT03249311_exc_T61", "normalized": [] }, { "id": "NCT03249311_exc_R22", "type": "AND", "arg1_id": "NCT03249311_exc_T60", "arg2_id": "NCT03249311_exc_T63", "normalized": [] }, { "id": "NCT03249311_exc_R23", "type": "Has_qualifier", "arg1_id": "NCT03249311_exc_T68", "arg2_id": "NCT03249311_exc_T69", "normalized": [] }, { "id": "NCT03249311_exc_R24", "type": "Has_temporal", "arg1_id": "NCT03249311_exc_T71", "arg2_id": "NCT03249311_exc_T70", "normalized": [] }, { "id": "NCT03249311_exc_R25", "type": "Has_qualifier", "arg1_id": "NCT03249311_exc_T80", "arg2_id": "NCT03249311_exc_T81", "normalized": [] }, { "id": "NCT03249311_exc_R26", "type": "Has_qualifier", "arg1_id": "NCT03249311_exc_T82", "arg2_id": "NCT03249311_exc_T83", "normalized": [] }, { "id": "NCT03249311_exc_R27", "type": "Has_temporal", "arg1_id": "NCT03249311_exc_T84", "arg2_id": "NCT03249311_exc_T85", "normalized": [] }, { "id": "NCT03249311_exc_R28", "type": "Has_mood", "arg1_id": "NCT03249311_exc_T89", "arg2_id": "NCT03249311_exc_T88", "normalized": [] } ]

[ { "id": "NCT03249311_inc_text", "type": "inclusion", "text": [ "Male participants between 18 and 40 years-old\nWritten informed consent signed by the participant\n" ], "offsets": [ [ 0, 97 ] ] } ]

[ { "id": "NCT03249311_inc_T1", "type": "Person", "text": [ "Male" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03249311_inc_T2", "type": "Value", "text": [ "between 18 and 40 years" ], "offsets": [ [ 18, 41 ] ], "normalized": [] }, { "id": "NCT03249311_inc_T3", "type": "Person", "text": [ "old" ], "offsets": [ [ 42, 45 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03249311_inc_R1", "type": "Has_value", "arg1_id": "NCT03249311_inc_T3", "arg2_id": "NCT03249311_inc_T2", "normalized": [] } ]

[ { "id": "NCT03250507_exc_text", "type": "exclusion", "text": [ "Patient with a chronic pain condition, major unexpected surgical complication, unexpected prolonged intubation, patient refusal, local anesthetic allergy, any contraindication to regional anesthesia, greater than 2 attempts by resident and greater than 1 attempt by staff anesthesiologist for TAP block.\n" ], "offsets": [ [ 0, 304 ] ] } ]

[ { "id": "NCT03250507_exc_T1", "type": "Condition", "text": [ "chronic pain condition" ], "offsets": [ [ 15, 37 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T2", "type": "Qualifier", "text": [ "major" ], "offsets": [ [ 39, 44 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T3", "type": "Condition", "text": [ "unexpected surgical complication" ], "offsets": [ [ 45, 77 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T4", "type": "Multiplier", "text": [ "prolonged" ], "offsets": [ [ 90, 99 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T5", "type": "Procedure", "text": [ "intubation" ], "offsets": [ [ 100, 110 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T6", "type": "Qualifier", "text": [ "unexpected" ], "offsets": [ [ 79, 89 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T7", "type": "Observation", "text": [ "patient refusal" ], "offsets": [ [ 112, 127 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T8", "type": "Drug", "text": [ "local anesthetic" ], "offsets": [ [ 129, 145 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T9", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 146, 153 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T10", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 159, 175 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T11", "type": "Drug", "text": [ "regional anesthesia" ], "offsets": [ [ 179, 198 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T12", "type": "Multiplier", "text": [ "greater than 2" ], "offsets": [ [ 200, 214 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T13", "type": "Multiplier", "text": [ "greater than 1" ], "offsets": [ [ 240, 254 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T14", "type": "Procedure", "text": [ "TAP block" ], "offsets": [ [ 293, 302 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T15", "type": "Person", "text": [ "resident" ], "offsets": [ [ 227, 235 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T16", "type": "Person", "text": [ "anesthesiologist" ], "offsets": [ [ 272, 288 ] ], "normalized": [] }, { "id": "NCT03250507_exc_T17", "type": "Scope", "text": [ "greater than 2 attempts by resident and greater than 1 attempt by staff anesthesiologist" ], "offsets": [ [ 200, 288 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03250507_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03250507_exc_T3", "arg2_id": "NCT03250507_exc_T2", "normalized": [] }, { "id": "NCT03250507_exc_R2", "type": "Has_multiplier", "arg1_id": "NCT03250507_exc_T5", "arg2_id": "NCT03250507_exc_T4", "normalized": [] }, { "id": "NCT03250507_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03250507_exc_T5", "arg2_id": "NCT03250507_exc_T6", "normalized": [] }, { "id": "NCT03250507_exc_R4", "type": "AND", "arg1_id": "NCT03250507_exc_T9", "arg2_id": "NCT03250507_exc_T8", "normalized": [] }, { "id": "NCT03250507_exc_R5", "type": "AND", "arg1_id": "NCT03250507_exc_T10", "arg2_id": "NCT03250507_exc_T11", "normalized": [] }, { "id": "NCT03250507_exc_R6", "type": "Has_multiplier", "arg1_id": "NCT03250507_exc_T15", "arg2_id": "NCT03250507_exc_T12", "normalized": [] }, { "id": "NCT03250507_exc_R7", "type": "Has_multiplier", "arg1_id": "NCT03250507_exc_T16", "arg2_id": "NCT03250507_exc_T13", "normalized": [] }, { "id": "NCT03250507_exc_R8", "type": "Has_scope", "arg1_id": "NCT03250507_exc_T14", "arg2_id": "NCT03250507_exc_T17", "normalized": [] } ]

[ { "id": "NCT03250507_inc_text", "type": "inclusion", "text": [ "Elective open abdominal hysterectomy with midline incision, age > 18 years, American Society of Anesthesiologist classification score (ASA classification) 1-3.\n" ], "offsets": [ [ 0, 160 ] ] } ]

[ { "id": "NCT03250507_inc_T1", "type": "Qualifier", "text": [ "Elective" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03250507_inc_T2", "type": "Procedure", "text": [ "open abdominal hysterectomy" ], "offsets": [ [ 9, 36 ] ], "normalized": [] }, { "id": "NCT03250507_inc_T3", "type": "Qualifier", "text": [ "midline incision" ], "offsets": [ [ 42, 58 ] ], "normalized": [] }, { "id": "NCT03250507_inc_T4", "type": "Person", "text": [ "age" ], "offsets": [ [ 60, 63 ] ], "normalized": [] }, { "id": "NCT03250507_inc_T5", "type": "Value", "text": [ "> 18 years" ], "offsets": [ [ 64, 74 ] ], "normalized": [] }, { "id": "NCT03250507_inc_T6", "type": "Measurement", "text": [ "American Society of Anesthesiologist classification score" ], "offsets": [ [ 76, 133 ] ], "normalized": [] }, { "id": "NCT03250507_inc_T7", "type": "Measurement", "text": [ "ASA classification" ], "offsets": [ [ 135, 153 ] ], "normalized": [] }, { "id": "NCT03250507_inc_T8", "type": "Value", "text": [ "1-3" ], "offsets": [ [ 155, 158 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03250507_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03250507_inc_T2", "arg2_id": "NCT03250507_inc_T1", "normalized": [] }, { "id": "NCT03250507_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03250507_inc_T2", "arg2_id": "NCT03250507_inc_T3", "normalized": [] }, { "id": "NCT03250507_inc_R3", "type": "Has_value", "arg1_id": "NCT03250507_inc_T4", "arg2_id": "NCT03250507_inc_T5", "normalized": [] }, { "id": "NCT03250507_inc_R4", "type": "Subsumes", "arg1_id": "NCT03250507_inc_T6", "arg2_id": "NCT03250507_inc_T7", "normalized": [] }, { "id": "NCT03250507_inc_R5", "type": "Has_value", "arg1_id": "NCT03250507_inc_T6", "arg2_id": "NCT03250507_inc_T8", "normalized": [] } ]

[ { "id": "NCT03252249_exc_text", "type": "exclusion", "text": [ "Clear indication for specific duration of dual anti-platelet therapy\nType 2 myocardial infarction\nContraindication to aspirin or P2Y12 receptor antagonist\nNon-resident of Scotland\nPrevious recruitment into the trial\nInability or unwilling to give informed consent\n" ], "offsets": [ [ 0, 264 ] ] } ]

[ { "id": "NCT03252249_exc_T1", "type": "Procedure", "text": [ "dual anti-platelet therapy" ], "offsets": [ [ 42, 68 ] ], "normalized": [] }, { "id": "NCT03252249_exc_T2", "type": "Condition", "text": [ "Clear indication for specific duration" ], "offsets": [ [ 0, 38 ] ], "normalized": [] }, { "id": "NCT03252249_exc_T3", "type": "Condition", "text": [ "Type 2 myocardial infarction" ], "offsets": [ [ 69, 97 ] ], "normalized": [] }, { "id": "NCT03252249_exc_T4", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 98, 114 ] ], "normalized": [] }, { "id": "NCT03252249_exc_T5", "type": "Condition", "text": [ "aspirin" ], "offsets": [ [ 118, 125 ] ], "normalized": [] }, { "id": "NCT03252249_exc_T6", "type": "Condition", "text": [ "P2Y12 receptor antagonist" ], "offsets": [ [ 129, 154 ] ], "normalized": [] }, { "id": "NCT03252249_exc_T7", "type": "Scope", "text": [ "aspirin or P2Y12 receptor antagonist" ], "offsets": [ [ 118, 154 ] ], "normalized": [] }, { "id": "NCT03252249_exc_T8", "type": "Person", "text": [ "Non-resident" ], "offsets": [ [ 155, 167 ] ], "normalized": [] }, { "id": "NCT03252249_exc_T9", "type": "Visit", "text": [ "Scotland" ], "offsets": [ [ 171, 179 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03252249_exc_R1", "type": "AND", "arg1_id": "NCT03252249_exc_T2", "arg2_id": "NCT03252249_exc_T1", "normalized": [] }, { "id": "NCT03252249_exc_R2", "type": "Has_scope", "arg1_id": "NCT03252249_exc_T4", "arg2_id": "NCT03252249_exc_T7", "normalized": [] }, { "id": "NCT03252249_exc_R3", "type": "AND", "arg1_id": "NCT03252249_exc_T8", "arg2_id": "NCT03252249_exc_T9", "normalized": [] } ]

[ { "id": "NCT03252249_inc_text", "type": "inclusion", "text": [ "Aged =18 years\nClinical diagnosis of acute coronary syndrome\nIn the opinion of the attending clinician requires dual anti-platelet therapy with aspirin and a P2Y12 receptor antagonist\nResident in Scotland with a Community Health Index (CHI) number\nThe attending clinician has equipoise regarding the duration of therapy\nProvision of informed consent\n" ], "offsets": [ [ 0, 350 ] ] } ]

[ { "id": "NCT03252249_inc_T1", "type": "Person", "text": [ "Aged" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03252249_inc_T2", "type": "Value", "text": [ "=18 years" ], "offsets": [ [ 5, 14 ] ], "normalized": [] }, { "id": "NCT03252249_inc_T3", "type": "Condition", "text": [ "acute coronary syndrome" ], "offsets": [ [ 37, 60 ] ], "normalized": [] }, { "id": "NCT03252249_inc_T4", "type": "Procedure", "text": [ "dual anti-platelet therapy" ], "offsets": [ [ 112, 138 ] ], "normalized": [] }, { "id": "NCT03252249_inc_T5", "type": "Drug", "text": [ "aspirin" ], "offsets": [ [ 144, 151 ] ], "normalized": [] }, { "id": "NCT03252249_inc_T6", "type": "Drug", "text": [ "P2Y12 receptor antagonist" ], "offsets": [ [ 158, 183 ] ], "normalized": [] }, { "id": "NCT03252249_inc_T7", "type": "Mood", "text": [ "requires" ], "offsets": [ [ 103, 111 ] ], "normalized": [] }, { "id": "NCT03252249_inc_T8", "type": "Person", "text": [ "Resident" ], "offsets": [ [ 184, 192 ] ], "normalized": [] }, { "id": "NCT03252249_inc_T9", "type": "Visit", "text": [ "Scotland" ], "offsets": [ [ 196, 204 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03252249_inc_R1", "type": "Has_value", "arg1_id": "NCT03252249_inc_T1", "arg2_id": "NCT03252249_inc_T2", "normalized": [] }, { "id": "NCT03252249_inc_R2", "type": "AND", "arg1_id": "NCT03252249_inc_T4", "arg2_id": "NCT03252249_inc_T5", "normalized": [] }, { "id": "NCT03252249_inc_R3", "type": "AND", "arg1_id": "NCT03252249_inc_T4", "arg2_id": "NCT03252249_inc_T6", "normalized": [] }, { "id": "NCT03252249_inc_R4", "type": "Has_mood", "arg1_id": "NCT03252249_inc_T4", "arg2_id": "NCT03252249_inc_T7", "normalized": [] }, { "id": "NCT03252249_inc_R5", "type": "AND", "arg1_id": "NCT03252249_inc_T8", "arg2_id": "NCT03252249_inc_T9", "normalized": [] } ]

[ { "id": "NCT03253796_exc_text", "type": "exclusion", "text": [ "Has bilateral sacroiliitis Grade 2 or unilateral sacroiliitis Grade 3 or Grade 4\nIs a nursing or pregnant female, or intends to become pregnant within 6 months after receiving trial medication\nIntends to donate eggs (female participants) or sperm (male participants) while receiving trial medication or within 6 months after trial medication\nHas any clinically significant condition or situation that would interfere with the trial evaluations or participation in the trial\nHas ever received any cytotoxic drugs, including chlorambucil, cyclophosphamide, nitrogen mustard, or other alkylating agents\n• Disease-modifying anti-rheumatic drugs (30 days off drug)\n• Live vaccinations (3 months off drug)\n• Investigational medications (30 days or 5 half-lives off drug, whichever is longer)\n• Bacille Calmette-Guerin (BCG) vaccination (12 months off drug)\nHas any systemic inflammatory condition, including psoriatic arthritis, active Lyme disease, systemic lupus erythematosus, infectious arthritis, vasculitis, parvovirus infection, rheumatoid arthritis, active uveitis, or active IBD\nHas a history of latent or active granulomatous infection prior to Screening\nHad a nontuberculous mycobacterial infection or opportunistic infection within 6 months prior to Screening\nHas a history of an infected joint prosthesis, or has received antibiotics for a suspected infection of a joint prosthesis, if that prosthesis has not been removed or replaced\nHad a serious infection, has been hospitalized for an infection, or has been treated with IV antibiotics for an infection within 2 months prior to Baseline\nHad a history of, or ongoing, chronic or recurrent infectious disease\nIs known to be infected with human immunodeficiency virus (HIV) or seropositive for hepatitis C virus (HCV)\nHas had a chest x-ray within 2 months prior to Screening that shows an abnormality suggestive of a current active infection or malignancy\nHas a history of lymphoproliferative disease\nHas had a malignancy within 5 years before screening (exceptions are squamous and basal cell carcinomas of the skin and carcinoma in situ of cervix that has been surgically cured)\nHas a history of known demyelinating diseases such as multiple sclerosis or optic neuritis\nHas a history of or concurrent congestive heart failure of any grade\nHas a transplanted organ (with the exception of a corneal transplant performed >= 3 months prior to baseline)\nHas current signs or symptoms of significant medical illness which could interfere with the trial, or require treatment that might interfere with the trial\nIs a user of recreational or illicit drugs or has or had a substance abuse (drug or alcohol) problem within the previous 2 years\n" ], "offsets": [ [ 0, 2694 ] ] } ]

[ { "id": "NCT03253796_exc_T1", "type": "Qualifier", "text": [ "bilateral" ], "offsets": [ [ 4, 13 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T2", "type": "Condition", "text": [ "sacroiliitis" ], "offsets": [ [ 14, 26 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T3", "type": "Qualifier", "text": [ "Grade 2" ], "offsets": [ [ 27, 34 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T4", "type": "Qualifier", "text": [ "unilateral" ], "offsets": [ [ 38, 48 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T5", "type": "Condition", "text": [ "sacroiliitis" ], "offsets": [ [ 49, 61 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T6", "type": "Qualifier", "text": [ "Grade 3" ], "offsets": [ [ 62, 69 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T7", "type": "Qualifier", "text": [ "Grade 4" ], "offsets": [ [ 73, 80 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T8", "type": "Scope", "text": [ "Grade 3 or Grade 4" ], "offsets": [ [ 62, 80 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T9", "type": "Condition", "text": [ "nursing" ], "offsets": [ [ 86, 93 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T10", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 97, 105 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T11", "type": "Person", "text": [ "female" ], "offsets": [ [ 106, 112 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T12", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 135, 143 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T13", "type": "Temporal", "text": [ "within 6 months after receiving trial medication" ], "offsets": [ [ 144, 192 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T14", "type": "Mood", "text": [ "intends to become" ], "offsets": [ [ 117, 134 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T15", "type": "Procedure", "text": [ "donate eggs" ], "offsets": [ [ 204, 215 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T16", "type": "Procedure", "text": [ "nate e", "erm (" ], "offsets": [ [ 206, 212 ], [ 243, 248 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T17", "type": "Person", "text": [ "female" ], "offsets": [ [ 217, 223 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T18", "type": "Person", "text": [ "male" ], "offsets": [ [ 248, 252 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T19", "type": "Temporal", "text": [ "while receiving trial medication" ], "offsets": [ [ 267, 299 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T20", "type": "Temporal", "text": [ "within 6 months after trial medication" ], "offsets": [ [ 303, 341 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T21", "type": "Reference_point", "text": [ "trial medication" ], "offsets": [ [ 325, 341 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T22", "type": "Reference_point", "text": [ "trial medication" ], "offsets": [ [ 283, 299 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T23", "type": "Scope", "text": [ "donate eggs (female participants) or sperm (male participants)" ], "offsets": [ [ 204, 266 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T24", "type": "Scope", "text": [ "while receiving trial medication or within 6 months after trial medication" ], "offsets": [ [ 267, 341 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T26", "type": "Drug", "text": [ "cytotoxic drugs" ], "offsets": [ [ 496, 511 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T27", "type": "Drug", "text": [ "chlorambucil" ], "offsets": [ [ 523, 535 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T28", "type": "Drug", "text": [ "cyclophosphamide" ], "offsets": [ [ 537, 553 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T29", "type": "Drug", "text": [ "nitrogen mustard" ], "offsets": [ [ 555, 571 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T30", "type": "Drug", "text": [ "alkylating agents" ], "offsets": [ [ 582, 599 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T31", "type": "Scope", "text": [ "chlorambucil, cyclophosphamide, nitrogen mustard, or other alkylating agents" ], "offsets": [ [ 523, 599 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T32", "type": "Drug", "text": [ "Disease-modifying anti-rheumatic drugs" ], "offsets": [ [ 602, 640 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T33", "type": "Temporal", "text": [ "30 days off drug" ], "offsets": [ [ 642, 658 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T34", "type": "Drug", "text": [ "Live vaccinations" ], "offsets": [ [ 662, 679 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T35", "type": "Temporal", "text": [ "3 months off drug" ], "offsets": [ [ 681, 698 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T36", "type": "Drug", "text": [ "Investigational medications" ], "offsets": [ [ 702, 729 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T37", "type": "Temporal", "text": [ " or 5 ", "g, which" ], "offsets": [ [ 738, 744 ], [ 762, 770 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T38", "type": "Temporal", "text": [ "5 half-lives off drug" ], "offsets": [ [ 742, 763 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T39", "type": "Scope", "text": [ "30 days or 5 half-lives off drug" ], "offsets": [ [ 731, 763 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T40", "type": "Drug", "text": [ "Bacille Calmette-Guerin (BCG) vaccination" ], "offsets": [ [ 788, 829 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T41", "type": "Temporal", "text": [ "12 months off drug" ], "offsets": [ [ 831, 849 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T42", "type": "Condition", "text": [ "inflammatory condition" ], "offsets": [ [ 868, 890 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T43", "type": "Condition", "text": [ "psoriatic arthritis" ], "offsets": [ [ 902, 921 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T44", "type": "Condition", "text": [ "Lyme disease" ], "offsets": [ [ 930, 942 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T45", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 923, 929 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T46", "type": "Condition", "text": [ "systemic lupus erythematosus" ], "offsets": [ [ 944, 972 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T47", "type": "Condition", "text": [ "infectious arthritis" ], "offsets": [ [ 974, 994 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T48", "type": "Condition", "text": [ "vasculitis" ], "offsets": [ [ 996, 1006 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T49", "type": "Condition", "text": [ "parvovirus infection" ], "offsets": [ [ 1008, 1028 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T50", "type": "Condition", "text": [ "rheumatoid arthritis" ], "offsets": [ [ 1030, 1050 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T51", "type": "Condition", "text": [ "active uveitis" ], "offsets": [ [ 1052, 1066 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T52", "type": "Condition", "text": [ "active IBD" ], "offsets": [ [ 1071, 1081 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T53", "type": "Scope", "text": [ "psoriatic arthritis, active Lyme disease, systemic lupus erythematosus, infectious arthritis, vasculitis, parvovirus infection, rheumatoid arthritis, active uveitis, or active IBD" ], "offsets": [ [ 902, 1081 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T54", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 1109, 1115 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T55", "type": "Qualifier", "text": [ "latent" ], "offsets": [ [ 1099, 1105 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T56", "type": "Condition", "text": [ "granulomatous infection" ], "offsets": [ [ 1116, 1139 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T57", "type": "Temporal", "text": [ "prior to Screening" ], "offsets": [ [ 1140, 1158 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T58", "type": "Reference_point", "text": [ "Screening" ], "offsets": [ [ 1149, 1158 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T59", "type": "Scope", "text": [ "latent or active" ], "offsets": [ [ 1099, 1115 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T60", "type": "Condition", "text": [ "nontuberculous mycobacterial infection" ], "offsets": [ [ 1165, 1203 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T61", "type": "Condition", "text": [ "opportunistic infection" ], "offsets": [ [ 1207, 1230 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T62", "type": "Temporal", "text": [ "within 6 months prior to Screening" ], "offsets": [ [ 1231, 1265 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T63", "type": "Scope", "text": [ "nontuberculous mycobacterial infection or opportunistic infection" ], "offsets": [ [ 1165, 1230 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T64", "type": "Condition", "text": [ "infected" ], "offsets": [ [ 1286, 1294 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T65", "type": "Device", "text": [ "joint prosthesis" ], "offsets": [ [ 1295, 1311 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T66", "type": "Observation", "text": [ "history" ], "offsets": [ [ 1272, 1279 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T67", "type": "Drug", "text": [ "antibiotics" ], "offsets": [ [ 1329, 1340 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T68", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 1347, 1356 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T69", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 1357, 1366 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T70", "type": "Device", "text": [ "joint prosthesis" ], "offsets": [ [ 1372, 1388 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T71", "type": "Condition", "text": [ "serious infection" ], "offsets": [ [ 1448, 1465 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T72", "type": "Procedure", "text": [ "hospitalized" ], "offsets": [ [ 1476, 1488 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T73", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 1496, 1505 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T74", "type": "Drug", "text": [ "IV antibiotics" ], "offsets": [ [ 1532, 1546 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T75", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 1554, 1563 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T76", "type": "Temporal", "text": [ "within 2 months prior to Baseline" ], "offsets": [ [ 1564, 1597 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T77", "type": "Qualifier", "text": [ "recurrent" ], "offsets": [ [ 1639, 1648 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T78", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 1628, 1635 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T79", "type": "Temporal", "text": [ "ongoing" ], "offsets": [ [ 1619, 1626 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T80", "type": "Observation", "text": [ "history" ], "offsets": [ [ 1604, 1611 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T81", "type": "Scope", "text": [ "history of, or ongoing" ], "offsets": [ [ 1604, 1626 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T82", "type": "Scope", "text": [ "chronic or recurrent" ], "offsets": [ [ 1628, 1648 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T83", "type": "Condition", "text": [ "infectious disease" ], "offsets": [ [ 1649, 1667 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T84", "type": "Condition", "text": [ "human immunodeficiency virus (HIV)" ], "offsets": [ [ 1697, 1731 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T85", "type": "Condition", "text": [ "seropositive for hepatitis C virus (HCV)" ], "offsets": [ [ 1735, 1775 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T86", "type": "Procedure", "text": [ "chest x-ray" ], "offsets": [ [ 1786, 1797 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T87", "type": "Temporal", "text": [ "within 2 months prior to Screening" ], "offsets": [ [ 1798, 1832 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T88", "type": "Condition", "text": [ "abnormality" ], "offsets": [ [ 1847, 1858 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T89", "type": "Mood", "text": [ "suggestive" ], "offsets": [ [ 1859, 1869 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T90", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 1875, 1882 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T91", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 1883, 1889 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T92", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 1890, 1899 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T93", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 1903, 1913 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T94", "type": "Scope", "text": [ "infection or malignancy" ], "offsets": [ [ 1890, 1913 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T95", "type": "Condition", "text": [ "lymphoproliferative disease" ], "offsets": [ [ 1931, 1958 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T96", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 1969, 1979 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T97", "type": "Temporal", "text": [ "within 5 years before screening" ], "offsets": [ [ 1980, 2011 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T98", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 2002, 2011 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T99", "type": "Reference_point", "text": [ "Screening" ], "offsets": [ [ 1823, 1832 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T100", "type": "Condition", "text": [ " cell c", "skin and carcinoma in" ], "offsets": [ [ 2046, 2053 ], [ 2070, 2091 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T101", "type": "Condition", "text": [ "basal cell carcinomas of the skin" ], "offsets": [ [ 2041, 2074 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T102", "type": "Condition", "text": [ "carcinoma in situ" ], "offsets": [ [ 2079, 2096 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T103", "type": "Qualifier", "text": [ "cervix" ], "offsets": [ [ 2100, 2106 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T104", "type": "Qualifier", "text": [ "surgically cured" ], "offsets": [ [ 2121, 2137 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T105", "type": "Procedure", "text": [ "surgically" ], "offsets": [ [ 2121, 2131 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T106", "type": "Negation", "text": [ "exceptions" ], "offsets": [ [ 2013, 2023 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T107", "type": "Scope", "text": [ "squamous and basal cell carcinomas of the skin and carcinoma in situ of cervix that has been surgically cured" ], "offsets": [ [ 2028, 2137 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T108", "type": "Condition", "text": [ "demyelinating diseases" ], "offsets": [ [ 2162, 2184 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T109", "type": "Observation", "text": [ "history" ], "offsets": [ [ 2145, 2152 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T110", "type": "Condition", "text": [ "multiple sclerosis" ], "offsets": [ [ 2193, 2211 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T111", "type": "Condition", "text": [ "optic neuritis" ], "offsets": [ [ 2215, 2229 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T112", "type": "Scope", "text": [ "multiple sclerosis or optic neuritis" ], "offsets": [ [ 2193, 2229 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T113", "type": "Condition", "text": [ "congestive heart failure" ], "offsets": [ [ 2261, 2285 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T114", "type": "Temporal", "text": [ "concurrent" ], "offsets": [ [ 2250, 2260 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T115", "type": "Observation", "text": [ "history" ], "offsets": [ [ 2236, 2243 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T116", "type": "Scope", "text": [ "history of or concurrent" ], "offsets": [ [ 2236, 2260 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T117", "type": "Procedure", "text": [ "transplanted organ" ], "offsets": [ [ 2305, 2323 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T118", "type": "Procedure", "text": [ "corneal transplant" ], "offsets": [ [ 2349, 2367 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T119", "type": "Temporal", "text": [ ">= 3 months prior to baseline" ], "offsets": [ [ 2378, 2407 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T120", "type": "Negation", "text": [ "exception of" ], "offsets": [ [ 2334, 2346 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T121", "type": "Condition", "text": [ "medical illness" ], "offsets": [ [ 2454, 2469 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T122", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 2442, 2453 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T123", "type": "Observation", "text": [ "interfere with the trial" ], "offsets": [ [ 2482, 2506 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T124", "type": "Mood", "text": [ "require" ], "offsets": [ [ 2511, 2518 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T125", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 2519, 2528 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T126", "type": "Observation", "text": [ "interfere with the trial" ], "offsets": [ [ 2540, 2564 ] ], "normalized": [] }, { "id": "NCT03253796_exc_T127", "type": "Scope", "text": [ "interfere with the trial, or require treatment that might interfere with the trial" ], "offsets": [ [ 2482, 2564 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03253796_exc_R1", "type": "Has_scope", "arg1_id": "NCT03253796_exc_T5", "arg2_id": "NCT03253796_exc_T8", "normalized": [] }, { "id": "NCT03253796_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03253796_exc_T5", "arg2_id": "NCT03253796_exc_T4", "normalized": [] }, { "id": "NCT03253796_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03253796_exc_T2", "arg2_id": "NCT03253796_exc_T3", "normalized": [] }, { "id": "NCT03253796_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03253796_exc_T2", "arg2_id": "NCT03253796_exc_T1", "normalized": [] }, { "id": "NCT03253796_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T12", "arg2_id": "NCT03253796_exc_T13", "normalized": [] }, { "id": "NCT03253796_exc_R6", "type": "Has_mood", "arg1_id": "NCT03253796_exc_T12", "arg2_id": "NCT03253796_exc_T14", "normalized": [] }, { "id": "NCT03253796_exc_R7", "type": "Has_index", "arg1_id": "NCT03253796_exc_T19", "arg2_id": "NCT03253796_exc_T22", "normalized": [] }, { "id": "NCT03253796_exc_R8", "type": "Has_index", "arg1_id": "NCT03253796_exc_T20", "arg2_id": "NCT03253796_exc_T21", "normalized": [] }, { "id": "NCT03253796_exc_R9", "type": "AND", "arg1_id": "NCT03253796_exc_T17", "arg2_id": "NCT03253796_exc_T15", "normalized": [] }, { "id": "NCT03253796_exc_R10", "type": "AND", "arg1_id": "NCT03253796_exc_T18", "arg2_id": "NCT03253796_exc_T16", "normalized": [] }, { "id": "NCT03253796_exc_R11", "type": "Has_scope", "arg1_id": "NCT03253796_exc_T23", "arg2_id": "NCT03253796_exc_T24", "normalized": [] }, { "id": "NCT03253796_exc_R12", "type": "Subsumes", "arg1_id": "NCT03253796_exc_T26", "arg2_id": "NCT03253796_exc_T31", "normalized": [] }, { "id": "NCT03253796_exc_R13", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T32", "arg2_id": "NCT03253796_exc_T33", "normalized": [] }, { "id": "NCT03253796_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T34", "arg2_id": "NCT03253796_exc_T35", "normalized": [] }, { "id": "NCT03253796_exc_R15", "type": "Has_scope", "arg1_id": "NCT03253796_exc_T36", "arg2_id": "NCT03253796_exc_T39", "normalized": [] }, { "id": "NCT03253796_exc_R16", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T40", "arg2_id": "NCT03253796_exc_T41", "normalized": [] }, { "id": "NCT03253796_exc_R17", "type": "Has_qualifier", "arg1_id": "NCT03253796_exc_T44", "arg2_id": "NCT03253796_exc_T45", "normalized": [] }, { "id": "NCT03253796_exc_R18", "type": "Subsumes", "arg1_id": "NCT03253796_exc_T42", "arg2_id": "NCT03253796_exc_T53", "normalized": [] }, { "id": "NCT03253796_exc_R19", "type": "Has_index", "arg1_id": "NCT03253796_exc_T57", "arg2_id": "NCT03253796_exc_T58", "normalized": [] }, { "id": "NCT03253796_exc_R20", "type": "Has_scope", "arg1_id": "NCT03253796_exc_T56", "arg2_id": "NCT03253796_exc_T59", "normalized": [] }, { "id": "NCT03253796_exc_R21", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T56", "arg2_id": "NCT03253796_exc_T57", "normalized": [] }, { "id": "NCT03253796_exc_R22", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T63", "arg2_id": "NCT03253796_exc_T62", "normalized": [] }, { "id": "NCT03253796_exc_R23", "type": "AND", "arg1_id": "NCT03253796_exc_T64", "arg2_id": "NCT03253796_exc_T65", "normalized": [] }, { "id": "NCT03253796_exc_R24", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T64", "arg2_id": "NCT03253796_exc_T66", "normalized": [] }, { "id": "NCT03253796_exc_R25", "type": "AND", "arg1_id": "NCT03253796_exc_T69", "arg2_id": "NCT03253796_exc_T70", "normalized": [] }, { "id": "NCT03253796_exc_R26", "type": "Has_mood", "arg1_id": "NCT03253796_exc_T69", "arg2_id": "NCT03253796_exc_T68", "normalized": [] }, { "id": "NCT03253796_exc_R27", "type": "AND", "arg1_id": "NCT03253796_exc_T67", "arg2_id": "NCT03253796_exc_T69", "normalized": [] }, { "id": "NCT03253796_exc_R28", "type": "AND", "arg1_id": "NCT03253796_exc_T72", "arg2_id": "NCT03253796_exc_T73", "normalized": [] }, { "id": "NCT03253796_exc_R29", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T74", "arg2_id": "NCT03253796_exc_T76", "normalized": [] }, { "id": "NCT03253796_exc_R30", "type": "AND", "arg1_id": "NCT03253796_exc_T74", "arg2_id": "NCT03253796_exc_T75", "normalized": [] }, { "id": "NCT03253796_exc_R31", "type": "Has_scope", "arg1_id": "NCT03253796_exc_T83", "arg2_id": "NCT03253796_exc_T82", "normalized": [] }, { "id": "NCT03253796_exc_R32", "type": "Has_scope", "arg1_id": "NCT03253796_exc_T83", "arg2_id": "NCT03253796_exc_T81", "normalized": [] }, { "id": "NCT03253796_exc_R33", "type": "Has_qualifier", "arg1_id": "NCT03253796_exc_T94", "arg2_id": "NCT03253796_exc_T91", "normalized": [] }, { "id": "NCT03253796_exc_R34", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T94", "arg2_id": "NCT03253796_exc_T90", "normalized": [] }, { "id": "NCT03253796_exc_R35", "type": "Has_mood", "arg1_id": "NCT03253796_exc_T94", "arg2_id": "NCT03253796_exc_T89", "normalized": [] }, { "id": "NCT03253796_exc_R36", "type": "Has_scope", "arg1_id": "NCT03253796_exc_T88", "arg2_id": "NCT03253796_exc_T94", "normalized": [] }, { "id": "NCT03253796_exc_R37", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T86", "arg2_id": "NCT03253796_exc_T87", "normalized": [] }, { "id": "NCT03253796_exc_R38", "type": "AND", "arg1_id": "NCT03253796_exc_T86", "arg2_id": "NCT03253796_exc_T88", "normalized": [] }, { "id": "NCT03253796_exc_R39", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T96", "arg2_id": "NCT03253796_exc_T97", "normalized": [] }, { "id": "NCT03253796_exc_R40", "type": "Has_index", "arg1_id": "NCT03253796_exc_T97", "arg2_id": "NCT03253796_exc_T98", "normalized": [] }, { "id": "NCT03253796_exc_R41", "type": "Has_index", "arg1_id": "NCT03253796_exc_T87", "arg2_id": "NCT03253796_exc_T99", "normalized": [] }, { "id": "NCT03253796_exc_R42", "type": "Has_qualifier", "arg1_id": "NCT03253796_exc_T102", "arg2_id": "NCT03253796_exc_T103", "normalized": [] }, { "id": "NCT03253796_exc_R44", "type": "Has_qualifier", "arg1_id": "NCT03253796_exc_T102", "arg2_id": "NCT03253796_exc_T104", "normalized": [] }, { "id": "NCT03253796_exc_R45", "type": "Has_negation", "arg1_id": "NCT03253796_exc_T107", "arg2_id": "NCT03253796_exc_T106", "normalized": [] }, { "id": "NCT03253796_exc_R46", "type": "Has_scope", "arg1_id": "NCT03253796_exc_T96", "arg2_id": "NCT03253796_exc_T107", "normalized": [] }, { "id": "NCT03253796_exc_R47", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T108", "arg2_id": "NCT03253796_exc_T109", "normalized": [] }, { "id": "NCT03253796_exc_R48", "type": "Subsumes", "arg1_id": "NCT03253796_exc_T108", "arg2_id": "NCT03253796_exc_T112", "normalized": [] }, { "id": "NCT03253796_exc_R49", "type": "Has_scope", "arg1_id": "NCT03253796_exc_T113", "arg2_id": "NCT03253796_exc_T116", "normalized": [] }, { "id": "NCT03253796_exc_R50", "type": "Has_temporal", "arg1_id": "NCT03253796_exc_T118", "arg2_id": "NCT03253796_exc_T119", "normalized": [] }, { "id": "NCT03253796_exc_R51", "type": "Has_negation", "arg1_id": "NCT03253796_exc_T118", "arg2_id": "NCT03253796_exc_T120", "normalized": [] }, { "id": "NCT03253796_exc_R52", "type": "AND", "arg1_id": "NCT03253796_exc_T117", "arg2_id": "NCT03253796_exc_T118", "normalized": [] }, { "id": "NCT03253796_exc_R53", "type": "Has_qualifier", "arg1_id": "NCT03253796_exc_T121", "arg2_id": "NCT03253796_exc_T122", "normalized": [] }, { "id": "NCT03253796_exc_R54", "type": "Has_mood", "arg1_id": "NCT03253796_exc_T125", "arg2_id": "NCT03253796_exc_T124", "normalized": [] }, { "id": "NCT03253796_exc_R56", "type": "Has_scope", "arg1_id": "NCT03253796_exc_T121", "arg2_id": "NCT03253796_exc_T127", "normalized": [] } ]

[ { "id": "NCT03253796_inc_text", "type": "inclusion", "text": [ "Is not of reproductive potential, or is of reproductive potential and agrees to avoid becoming pregnant or impregnating a partner while receiving trial medication or within 6 months after the last dose of trial medication\nHas chronic back pain of =3 months duration by history\nHas physician-diagnosed active nr-axSpA with disease duration <= 5 years\n• Inflammatory back pain\n• Arthritis (physician-diagnosed)\n• Enthesitis (heel) physician-diagnosed (spontaneous pain or tenderness at examination of the site of the insertion of the Achilles tendon or plantar fascia)\n• Dactylitis (physician-diagnosed)\n• Psoriasis (physician-diagnosed)\n• History of physician-diagnosed inflammatory bowel disease (IBD)\n• History of uveitis confirmed by an ophthalmologist\n• Good response to nonsteroidal anti-inflammatory drugs (NSAID)\n• Family history of SpA (presence of ankylosing spondylitis, psoriasis, acute uveitis, reactive arthritis, or IBD)\n• Elevated CRP\n• Human leukocyte antigen B27 (HLA-B27)+ gene\nHas a HLA-B27+ gene and 2 or more of the SpA characteristics listed above\nHas elevated CRP at Screening or evidence of active inflammation in the sacroiliac joints on MRI\nHas an ASDAS >= 2.1 at Screening\nShows high disease activity at Screening and Baseline of both a Total Back Pain score of =4 and a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score of >= 4\nHas an acceptable history of NSAID use\nHas no history of untreated latent or active tuberculosis (TB) prior to Screening\nHas had no recent close contact with a person with active TB or, if there has been such contact, will undergo additional evaluations and receive appropriate treatment for latent TB\n" ], "offsets": [ [ 0, 1673 ] ] } ]

[ { "id": "NCT03253796_inc_T2", "type": "Condition", "text": [ "chronic back pain" ], "offsets": [ [ 226, 243 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T3", "type": "Qualifier", "text": [ "=3 months duration" ], "offsets": [ [ 247, 265 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T4", "type": "Observation", "text": [ "history" ], "offsets": [ [ 269, 276 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T5", "type": "Condition", "text": [ "nr-axSpA" ], "offsets": [ [ 308, 316 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T6", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 301, 307 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T7", "type": "Measurement", "text": [ "disease duration" ], "offsets": [ [ 322, 338 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T8", "type": "Measurement", "text": [ "duration" ], "offsets": [ [ 257, 265 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T9", "type": "Value", "text": [ "=3 months" ], "offsets": [ [ 247, 256 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T10", "type": "Value", "text": [ "<= 5 years" ], "offsets": [ [ 339, 349 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T11", "type": "Qualifier", "text": [ "disease duration <= 5 years" ], "offsets": [ [ 322, 349 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T12", "type": "Condition", "text": [ "Inflammatory back pain" ], "offsets": [ [ 352, 374 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T13", "type": "Condition", "text": [ "Arthritis" ], "offsets": [ [ 377, 386 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T14", "type": "Condition", "text": [ "Enthesitis" ], "offsets": [ [ 411, 421 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T15", "type": "Qualifier", "text": [ "heel" ], "offsets": [ [ 423, 427 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T16", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 462, 466 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T17", "type": "Condition", "text": [ "tenderness" ], "offsets": [ [ 470, 480 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T18", "type": "Qualifier", "text": [ "site of the insertion of the Achilles tendon" ], "offsets": [ [ 503, 547 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T19", "type": "Qualifier", "text": [ "plantar fascia" ], "offsets": [ [ 551, 565 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T20", "type": "Scope", "text": [ "site of the insertion of the Achilles tendon or plantar fascia" ], "offsets": [ [ 503, 565 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T21", "type": "Scope", "text": [ "pain or tenderness" ], "offsets": [ [ 462, 480 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T22", "type": "Condition", "text": [ "Dactylitis" ], "offsets": [ [ 569, 579 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T23", "type": "Condition", "text": [ "Psoriasis" ], "offsets": [ [ 604, 613 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T24", "type": "Condition", "text": [ "inflammatory bowel disease (IBD)" ], "offsets": [ [ 669, 701 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T25", "type": "Condition", "text": [ "uveitis" ], "offsets": [ [ 715, 722 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T27", "type": "Observation", "text": [ "History" ], "offsets": [ [ 638, 645 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T28", "type": "Observation", "text": [ "History" ], "offsets": [ [ 704, 711 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T29", "type": "Drug", "text": [ "nonsteroidal anti-inflammatory drugs (NSAID)" ], "offsets": [ [ 774, 818 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T30", "type": "Observation", "text": [ "Good response" ], "offsets": [ [ 757, 770 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T31", "type": "Observation", "text": [ "Family history" ], "offsets": [ [ 821, 835 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T32", "type": "Condition", "text": [ "SpA" ], "offsets": [ [ 839, 842 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T33", "type": "Condition", "text": [ "ankylosing spondylitis" ], "offsets": [ [ 856, 878 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T34", "type": "Condition", "text": [ "psoriasis" ], "offsets": [ [ 880, 889 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T35", "type": "Condition", "text": [ "acute uveitis" ], "offsets": [ [ 891, 904 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T36", "type": "Condition", "text": [ "reactive arthritis" ], "offsets": [ [ 906, 924 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T37", "type": "Condition", "text": [ "IBD" ], "offsets": [ [ 929, 932 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T38", "type": "Scope", "text": [ "ankylosing spondylitis, psoriasis, acute uveitis, reactive arthritis, or IBD" ], "offsets": [ [ 856, 932 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T39", "type": "Measurement", "text": [ "CRP" ], "offsets": [ [ 945, 948 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T40", "type": "Value", "text": [ "Elevated" ], "offsets": [ [ 936, 944 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T41", "type": "Condition", "text": [ "A-B2", "te antigen B27 (HLA-B27)+ g" ], "offsets": [ [ 1003, 1007 ], [ 964, 991 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T42", "type": "Condition", "text": [ "(HLA-B27)+" ], "offsets": [ [ 979, 989 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T43", "type": "Condition", "text": [ "HLA-B27+" ], "offsets": [ [ 1001, 1009 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T44", "type": "Condition", "text": [ "SpA" ], "offsets": [ [ 1036, 1039 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T45", "type": "Multiplier", "text": [ "2 or more" ], "offsets": [ [ 1019, 1028 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T46", "type": "Measurement", "text": [ "CRP" ], "offsets": [ [ 1082, 1085 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T47", "type": "Value", "text": [ "elevated" ], "offsets": [ [ 1073, 1081 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T48", "type": "Temporal", "text": [ "at Screening" ], "offsets": [ [ 1086, 1098 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T49", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 1114, 1120 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T50", "type": "Condition", "text": [ "inflammation" ], "offsets": [ [ 1121, 1133 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T51", "type": "Qualifier", "text": [ "sacroiliac joints" ], "offsets": [ [ 1141, 1158 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T52", "type": "Procedure", "text": [ "MRI" ], "offsets": [ [ 1162, 1165 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T53", "type": "Measurement", "text": [ "ASDAS" ], "offsets": [ [ 1173, 1178 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T54", "type": "Value", "text": [ ">= 2.1" ], "offsets": [ [ 1179, 1185 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T55", "type": "Temporal", "text": [ "at Screening" ], "offsets": [ [ 1186, 1198 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T56", "type": "Measurement", "text": [ "Total Back Pain score" ], "offsets": [ [ 1263, 1284 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T57", "type": "Value", "text": [ "=4" ], "offsets": [ [ 1288, 1290 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T58", "type": "Measurement", "text": [ "Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score" ], "offsets": [ [ 1297, 1362 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T59", "type": "Value", "text": [ ">= 4" ], "offsets": [ [ 1366, 1370 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T60", "type": "Condition", "text": [ "high disease activity" ], "offsets": [ [ 1205, 1226 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T61", "type": "Temporal", "text": [ "at Screening and Baseline" ], "offsets": [ [ 1227, 1252 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T62", "type": "Observation", "text": [ "history" ], "offsets": [ [ 1417, 1424 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T63", "type": "Qualifier", "text": [ "acceptable" ], "offsets": [ [ 1378, 1388 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T64", "type": "Drug", "text": [ "NSAID" ], "offsets": [ [ 1400, 1405 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T65", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 1448, 1454 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T66", "type": "Qualifier", "text": [ "untreated" ], "offsets": [ [ 1428, 1437 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T67", "type": "Qualifier", "text": [ "latent" ], "offsets": [ [ 1438, 1444 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T68", "type": "Condition", "text": [ "tuberculosis (TB)" ], "offsets": [ [ 1455, 1472 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T69", "type": "Scope", "text": [ "latent or active" ], "offsets": [ [ 1438, 1454 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T70", "type": "Negation", "text": [ "no" ], "offsets": [ [ 1414, 1416 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T71", "type": "Observation", "text": [ "history" ], "offsets": [ [ 1417, 1424 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T72", "type": "Scope", "text": [ "history of untreated latent or active tuberculosis (TB)" ], "offsets": [ [ 1417, 1472 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T73", "type": "Temporal", "text": [ "prior to Screening" ], "offsets": [ [ 1473, 1491 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T74", "type": "Reference_point", "text": [ "Screening" ], "offsets": [ [ 1482, 1491 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T75", "type": "Observation", "text": [ "close contact" ], "offsets": [ [ 1510, 1523 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T76", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 1503, 1509 ] ], "normalized": [] }, { "id": "NCT03253796_inc_T77", "type": "Observation", "text": [ "person with active TB" ], "offsets": [ [ 1531, 1552 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03253796_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03253796_inc_T2", "arg2_id": "NCT03253796_inc_T3", "normalized": [] }, { "id": "NCT03253796_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03253796_inc_T2", "arg2_id": "NCT03253796_inc_T4", "normalized": [] }, { "id": "NCT03253796_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03253796_inc_T5", "arg2_id": "NCT03253796_inc_T6", "normalized": [] }, { "id": "NCT03253796_inc_R4", "type": "Has_value", "arg1_id": "NCT03253796_inc_T8", "arg2_id": "NCT03253796_inc_T9", "normalized": [] }, { "id": "NCT03253796_inc_R6", "type": "Has_value", "arg1_id": "NCT03253796_inc_T7", "arg2_id": "NCT03253796_inc_T10", "normalized": [] }, { "id": "NCT03253796_inc_R7", "type": "Has_qualifier", "arg1_id": "NCT03253796_inc_T5", "arg2_id": "NCT03253796_inc_T11", "normalized": [] }, { "id": "NCT03253796_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT03253796_inc_T14", "arg2_id": "NCT03253796_inc_T15", "normalized": [] }, { "id": "NCT03253796_inc_R9", "type": "Has_scope", "arg1_id": "NCT03253796_inc_T21", "arg2_id": "NCT03253796_inc_T20", "normalized": [] }, { "id": "NCT03253796_inc_R10", "type": "Has_temporal", "arg1_id": "NCT03253796_inc_T24", "arg2_id": "NCT03253796_inc_T27", "normalized": [] }, { "id": "NCT03253796_inc_R11", "type": "Has_temporal", "arg1_id": "NCT03253796_inc_T25", "arg2_id": "NCT03253796_inc_T28", "normalized": [] }, { "id": "NCT03253796_inc_R12", "type": "AND", "arg1_id": "NCT03253796_inc_T30", "arg2_id": "NCT03253796_inc_T29", "normalized": [] }, { "id": "NCT03253796_inc_R13", "type": "Subsumes", "arg1_id": "NCT03253796_inc_T32", "arg2_id": "NCT03253796_inc_T38", "normalized": [] }, { "id": "NCT03253796_inc_R15", "type": "Has_value", "arg1_id": "NCT03253796_inc_T39", "arg2_id": "NCT03253796_inc_T40", "normalized": [] }, { "id": "NCT03253796_inc_R16", "type": "Subsumes", "arg1_id": "NCT03253796_inc_T41", "arg2_id": "NCT03253796_inc_T42", "normalized": [] }, { "id": "NCT03253796_inc_R17", "type": "Has_multiplier", "arg1_id": "NCT03253796_inc_T44", "arg2_id": "NCT03253796_inc_T45", "normalized": [] }, { "id": "NCT03253796_inc_R18", "type": "Has_value", "arg1_id": "NCT03253796_inc_T46", "arg2_id": "NCT03253796_inc_T47", "normalized": [] }, { "id": "NCT03253796_inc_R19", "type": "Has_temporal", "arg1_id": "NCT03253796_inc_T46", "arg2_id": "NCT03253796_inc_T48", "normalized": [] }, { "id": "NCT03253796_inc_R20", "type": "Has_qualifier", "arg1_id": "NCT03253796_inc_T50", "arg2_id": "NCT03253796_inc_T51", "normalized": [] }, { "id": "NCT03253796_inc_R21", "type": "AND", "arg1_id": "NCT03253796_inc_T50", "arg2_id": "NCT03253796_inc_T52", "normalized": [] }, { "id": "NCT03253796_inc_R22", "type": "Has_qualifier", "arg1_id": "NCT03253796_inc_T50", "arg2_id": "NCT03253796_inc_T49", "normalized": [] }, { "id": "NCT03253796_inc_R23", "type": "Has_value", "arg1_id": "NCT03253796_inc_T53", "arg2_id": "NCT03253796_inc_T54", "normalized": [] }, { "id": "NCT03253796_inc_R24", "type": "Has_temporal", "arg1_id": "NCT03253796_inc_T53", "arg2_id": "NCT03253796_inc_T55", "normalized": [] }, { "id": "NCT03253796_inc_R25", "type": "Has_value", "arg1_id": "NCT03253796_inc_T56", "arg2_id": "NCT03253796_inc_T57", "normalized": [] }, { "id": "NCT03253796_inc_R26", "type": "Has_value", "arg1_id": "NCT03253796_inc_T58", "arg2_id": "NCT03253796_inc_T59", "normalized": [] }, { "id": "NCT03253796_inc_R27", "type": "Has_temporal", "arg1_id": "NCT03253796_inc_T60", "arg2_id": "NCT03253796_inc_T61", "normalized": [] }, { "id": "NCT03253796_inc_R28", "type": "AND", "arg1_id": "NCT03253796_inc_T60", "arg2_id": "NCT03253796_inc_T56", "normalized": [] }, { "id": "NCT03253796_inc_R29", "type": "AND", "arg1_id": "NCT03253796_inc_T60", "arg2_id": "NCT03253796_inc_T58", "normalized": [] }, { "id": "NCT03253796_inc_R30", "type": "Has_temporal", "arg1_id": "NCT03253796_inc_T64", "arg2_id": "NCT03253796_inc_T62", "normalized": [] }, { "id": "NCT03253796_inc_R31", "type": "Has_qualifier", "arg1_id": "NCT03253796_inc_T64", "arg2_id": "NCT03253796_inc_T63", "normalized": [] }, { "id": "NCT03253796_inc_R32", "type": "Has_scope", "arg1_id": "NCT03253796_inc_T68", "arg2_id": "NCT03253796_inc_T69", "normalized": [] }, { "id": "NCT03253796_inc_R33", "type": "Has_qualifier", "arg1_id": "NCT03253796_inc_T68", "arg2_id": "NCT03253796_inc_T66", "normalized": [] }, { "id": "NCT03253796_inc_R34", "type": "Has_temporal", "arg1_id": "NCT03253796_inc_T68", "arg2_id": "NCT03253796_inc_T71", "normalized": [] }, { "id": "NCT03253796_inc_R35", "type": "Has_negation", "arg1_id": "NCT03253796_inc_T72", "arg2_id": "NCT03253796_inc_T70", "normalized": [] }, { "id": "NCT03253796_inc_R36", "type": "Has_index", "arg1_id": "NCT03253796_inc_T73", "arg2_id": "NCT03253796_inc_T74", "normalized": [] }, { "id": "NCT03253796_inc_R37", "type": "Has_temporal", "arg1_id": "NCT03253796_inc_T72", "arg2_id": "NCT03253796_inc_T73", "normalized": [] }, { "id": "NCT03253796_inc_R38", "type": "Has_temporal", "arg1_id": "NCT03253796_inc_T75", "arg2_id": "NCT03253796_inc_T76", "normalized": [] } ]

[ { "id": "NCT03255044_exc_text", "type": "exclusion", "text": [ "Known hypersensitivity to statin\nTreatment with statins during the past month prior to study.\nSerum creatinine > 3 mg/dl\nSignificant liver disease: liver enzymes 2.5 folds the upper normal limit\nMalignancy\nPregnancy or lactation\n" ], "offsets": [ [ 0, 229 ] ] } ]

[ { "id": "NCT03255044_exc_T1", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 6, 22 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T2", "type": "Drug", "text": [ "statin" ], "offsets": [ [ 26, 32 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T3", "type": "Drug", "text": [ "statins" ], "offsets": [ [ 48, 55 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T4", "type": "Temporal", "text": [ "during the past month prior to study" ], "offsets": [ [ 56, 92 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T5", "type": "Reference_point", "text": [ "the past month prior to study" ], "offsets": [ [ 63, 92 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T6", "type": "Measurement", "text": [ "Serum creatinine" ], "offsets": [ [ 94, 110 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T7", "type": "Value", "text": [ "> 3 mg/dl" ], "offsets": [ [ 111, 120 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T8", "type": "Condition", "text": [ "liver disease" ], "offsets": [ [ 133, 146 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T9", "type": "Measurement", "text": [ "liver enzymes" ], "offsets": [ [ 148, 161 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T10", "type": "Value", "text": [ "2.5 folds the upper normal limit" ], "offsets": [ [ 162, 194 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T11", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 121, 132 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T12", "type": "Scope", "text": [ "liver enzymes 2.5 folds the upper normal limit" ], "offsets": [ [ 148, 194 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T13", "type": "Scope", "text": [ "Significant liver disease" ], "offsets": [ [ 121, 146 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T14", "type": "Condition", "text": [ "Malignancy" ], "offsets": [ [ 195, 205 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T15", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 206, 215 ] ], "normalized": [] }, { "id": "NCT03255044_exc_T16", "type": "Condition", "text": [ "lactation" ], "offsets": [ [ 219, 228 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03255044_exc_R1", "type": "AND", "arg1_id": "NCT03255044_exc_T1", "arg2_id": "NCT03255044_exc_T2", "normalized": [] }, { "id": "NCT03255044_exc_R2", "type": "Has_index", "arg1_id": "NCT03255044_exc_T4", "arg2_id": "NCT03255044_exc_T5", "normalized": [] }, { "id": "NCT03255044_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03255044_exc_T3", "arg2_id": "NCT03255044_exc_T4", "normalized": [] }, { "id": "NCT03255044_exc_R4", "type": "Has_value", "arg1_id": "NCT03255044_exc_T6", "arg2_id": "NCT03255044_exc_T7", "normalized": [] }, { "id": "NCT03255044_exc_R5", "type": "Has_value", "arg1_id": "NCT03255044_exc_T9", "arg2_id": "NCT03255044_exc_T10", "normalized": [] }, { "id": "NCT03255044_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03255044_exc_T8", "arg2_id": "NCT03255044_exc_T11", "normalized": [] }, { "id": "NCT03255044_exc_R7", "type": "Subsumes", "arg1_id": "NCT03255044_exc_T13", "arg2_id": "NCT03255044_exc_T12", "normalized": [] } ]

[ { "id": "NCT03255044_inc_text", "type": "inclusion", "text": [ "older than 18 years (of both sexes)\ndiagnosed with stable chronic heart failure NYHA class II-III\nejection fraction < 40 % as assessed by 2D echocardiography\nwho have been optimized on Guideline Directed treatment for heart failure for at least a month prior to enrolling.\n" ], "offsets": [ [ 0, 273 ] ] } ]

[ { "id": "NCT03255044_inc_T1", "type": "Person", "text": [ "years" ], "offsets": [ [ 14, 19 ] ], "normalized": [] }, { "id": "NCT03255044_inc_T2", "type": "Value", "text": [ "older than 18" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT03255044_inc_T3", "type": "Person", "text": [ "both sexes" ], "offsets": [ [ 24, 34 ] ], "normalized": [] }, { "id": "NCT03255044_inc_T4", "type": "Qualifier", "text": [ "stable" ], "offsets": [ [ 51, 57 ] ], "normalized": [] }, { "id": "NCT03255044_inc_T5", "type": "Condition", "text": [ "chronic heart failure" ], "offsets": [ [ 58, 79 ] ], "normalized": [] }, { "id": "NCT03255044_inc_T6", "type": "Measurement", "text": [ "NYHA class" ], "offsets": [ [ 80, 90 ] ], "normalized": [] }, { "id": "NCT03255044_inc_T7", "type": "Value", "text": [ "II-III" ], "offsets": [ [ 91, 97 ] ], "normalized": [] }, { "id": "NCT03255044_inc_T8", "type": "Measurement", "text": [ "ejection fraction" ], "offsets": [ [ 98, 115 ] ], "normalized": [] }, { "id": "NCT03255044_inc_T9", "type": "Value", "text": [ "< 40 %" ], "offsets": [ [ 116, 122 ] ], "normalized": [] }, { "id": "NCT03255044_inc_T10", "type": "Procedure", "text": [ "2D echocardiography" ], "offsets": [ [ 138, 157 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03255044_inc_R1", "type": "Has_value", "arg1_id": "NCT03255044_inc_T1", "arg2_id": "NCT03255044_inc_T2", "normalized": [] }, { "id": "NCT03255044_inc_R2", "type": "Has_value", "arg1_id": "NCT03255044_inc_T6", "arg2_id": "NCT03255044_inc_T7", "normalized": [] }, { "id": "NCT03255044_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03255044_inc_T5", "arg2_id": "NCT03255044_inc_T4", "normalized": [] }, { "id": "NCT03255044_inc_R4", "type": "AND", "arg1_id": "NCT03255044_inc_T5", "arg2_id": "NCT03255044_inc_T6", "normalized": [] }, { "id": "NCT03255044_inc_R5", "type": "Has_value", "arg1_id": "NCT03255044_inc_T8", "arg2_id": "NCT03255044_inc_T9", "normalized": [] }, { "id": "NCT03255044_inc_R6", "type": "AND", "arg1_id": "NCT03255044_inc_T10", "arg2_id": "NCT03255044_inc_T8", "normalized": [] } ]

[ { "id": "NCT03256864_exc_text", "type": "exclusion", "text": [ "Patients who are recipients of multiple solid organ or islet cell tissue transplants, or have previously received an organ or tissue transplant. Patients who have a combined liver-kidney transplant.\nHistory of malignancy of any organ system (other than localized basal cell carcinoma of the skin), treated or untreated, within the past 5 years, regardless of whether there is evidence of local recurrence or metastases.\nExistence of any surgical, medical or mental conditions, other than the current transplantation, which, in the opinion of the investigator, might interfere with the objectives of the study.\nPregnant or nursing (lactating) women." ], "offsets": [ [ 0, 648 ] ] } ]

[ { "id": "NCT03256864_exc_T1", "type": "Multiplier", "text": [ "multiple" ], "offsets": [ [ 31, 39 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T2", "type": "Procedure", "text": [ "solid organ", "transplants" ], "offsets": [ [ 40, 51 ], [ 73, 84 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T3", "type": "Procedure", "text": [ "islet cell tissue transplants" ], "offsets": [ [ 55, 84 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T4", "type": "Scope", "text": [ "solid organ or islet cell tissue transplants" ], "offsets": [ [ 40, 84 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T5", "type": "Temporal", "text": [ "previously" ], "offsets": [ [ 94, 104 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T6", "type": "Procedure", "text": [ "organ", "transplant" ], "offsets": [ [ 117, 122 ], [ 133, 143 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T7", "type": "Procedure", "text": [ "tissue transplant" ], "offsets": [ [ 126, 143 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T8", "type": "Scope", "text": [ "organ or tissue transplant" ], "offsets": [ [ 117, 143 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T9", "type": "Procedure", "text": [ "combined liver-kidney transplant" ], "offsets": [ [ 165, 197 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T10", "type": "Observation", "text": [ "History" ], "offsets": [ [ 199, 206 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T11", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 210, 220 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T12", "type": "Qualifier", "text": [ "any organ system" ], "offsets": [ [ 224, 240 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T13", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 242, 252 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T14", "type": "Condition", "text": [ "localized basal cell carcinoma of the skin" ], "offsets": [ [ 253, 295 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T15", "type": "Scope", "text": [ "other than localized basal cell carcinoma of the skin" ], "offsets": [ [ 242, 295 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T16", "type": "Qualifier", "text": [ "treated" ], "offsets": [ [ 298, 305 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T17", "type": "Qualifier", "text": [ "untreated" ], "offsets": [ [ 309, 318 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T18", "type": "Temporal", "text": [ "within the past 5 years" ], "offsets": [ [ 320, 343 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T20", "type": "Scope", "text": [ "treated or untreated" ], "offsets": [ [ 298, 318 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T21", "type": "Condition", "text": [ "rgical,", "nditions," ], "offsets": [ [ 439, 446 ], [ 467, 476 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T22", "type": "Condition", "text": [ "dical o", "nditions," ], "offsets": [ [ 449, 456 ], [ 467, 476 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T23", "type": "Condition", "text": [ "mental conditions" ], "offsets": [ [ 458, 475 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T24", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 477, 487 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T25", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 492, 499 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T26", "type": "Procedure", "text": [ "transplantation" ], "offsets": [ [ 500, 515 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T27", "type": "Scope", "text": [ "surgical, medical or mental conditions" ], "offsets": [ [ 437, 475 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T28", "type": "Qualifier", "text": [ "might interfere with the objectives of the study" ], "offsets": [ [ 560, 608 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T29", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 610, 618 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T30", "type": "Observation", "text": [ "nursing" ], "offsets": [ [ 622, 629 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T31", "type": "Observation", "text": [ "lactating" ], "offsets": [ [ 631, 640 ] ], "normalized": [] }, { "id": "NCT03256864_exc_T32", "type": "Person", "text": [ "women" ], "offsets": [ [ 642, 647 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03256864_exc_R1", "type": "Has_multiplier", "arg1_id": "NCT03256864_exc_T4", "arg2_id": "NCT03256864_exc_T1", "normalized": [] }, { "id": "NCT03256864_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03256864_exc_T8", "arg2_id": "NCT03256864_exc_T5", "normalized": [] }, { "id": "NCT03256864_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03256864_exc_T11", "arg2_id": "NCT03256864_exc_T12", "normalized": [] }, { "id": "NCT03256864_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03256864_exc_T11", "arg2_id": "NCT03256864_exc_T10", "normalized": [] }, { "id": "NCT03256864_exc_R5", "type": "Has_negation", "arg1_id": "NCT03256864_exc_T14", "arg2_id": "NCT03256864_exc_T13", "normalized": [] }, { "id": "NCT03256864_exc_R6", "type": "Has_scope", "arg1_id": "NCT03256864_exc_T11", "arg2_id": "NCT03256864_exc_T15", "normalized": [] }, { "id": "NCT03256864_exc_R7", "type": "Has_scope", "arg1_id": "NCT03256864_exc_T11", "arg2_id": "NCT03256864_exc_T20", "normalized": [] }, { "id": "NCT03256864_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03256864_exc_T11", "arg2_id": "NCT03256864_exc_T18", "normalized": [] }, { "id": "NCT03256864_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03256864_exc_T26", "arg2_id": "NCT03256864_exc_T25", "normalized": [] }, { "id": "NCT03256864_exc_R10", "type": "Has_negation", "arg1_id": "NCT03256864_exc_T26", "arg2_id": "NCT03256864_exc_T24", "normalized": [] }, { "id": "NCT03256864_exc_R11", "type": "AND", "arg1_id": "NCT03256864_exc_T27", "arg2_id": "NCT03256864_exc_T26", "normalized": [] }, { "id": "NCT03256864_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT03256864_exc_T27", "arg2_id": "NCT03256864_exc_T28", "normalized": [] }, { "id": "NCT03256864_exc_R13", "type": "Subsumes", "arg1_id": "NCT03256864_exc_T30", "arg2_id": "NCT03256864_exc_T31", "normalized": [] } ]

[ { "id": "NCT03256864_inc_text", "type": "inclusion", "text": [ "Liver Transplant Recipients have received liver transplantations for at least 6+1 months prior to enrollment\nLiver Transplant Recipients have no acute rejection episodes within 3 months prior to the enrollment and are clinically stable\nLiver Transplant Recipients have been treated with twice-daily regimen of tacrolimus(TAC) plus everolimus(EVR) and TAC and EVR trough levels have stayed within targeted ranges for at least 6 weeks prior to enrollment\nProvide written informed consent prior to inclusion.\nLiver transplant recipients who are 18-65 years of age of a primary liver transplant\nAllograft functioning at an acceptable level as defined by the AST, ALT, Total Bilirubin levels =3 times ULN prior to enrollment.\nAbbreviated MDRD eGFR = 30 mL/min/1.73m2. " ], "offsets": [ [ 0, 763 ] ] } ]

[ { "id": "NCT03256864_inc_T1", "type": "Person", "text": [ "Liver Transplant Recipients" ], "offsets": [ [ 0, 27 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T2", "type": "Procedure", "text": [ "liver transplantations" ], "offsets": [ [ 42, 64 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T3", "type": "Temporal", "text": [ "for at least 6+1 months prior to enrollment" ], "offsets": [ [ 65, 108 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T4", "type": "Reference_point", "text": [ "enrollment" ], "offsets": [ [ 98, 108 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T5", "type": "Person", "text": [ "Liver Transplant Recipients" ], "offsets": [ [ 109, 136 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T6", "type": "Negation", "text": [ "no" ], "offsets": [ [ 142, 144 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T7", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 145, 150 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T8", "type": "Condition", "text": [ "rejection episodes" ], "offsets": [ [ 151, 169 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T9", "type": "Temporal", "text": [ "within 3 months prior to the enrollment" ], "offsets": [ [ 170, 209 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T10", "type": "Reference_point", "text": [ "the enrollment" ], "offsets": [ [ 195, 209 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T11", "type": "Condition", "text": [ "clinically stable" ], "offsets": [ [ 218, 235 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T12", "type": "Person", "text": [ "Liver Transplant Recipients" ], "offsets": [ [ 236, 263 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T14", "type": "Multiplier", "text": [ "twice-daily" ], "offsets": [ [ 287, 298 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T15", "type": "Drug", "text": [ "tacrolimus(TAC)" ], "offsets": [ [ 310, 325 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T16", "type": "Drug", "text": [ "everolimus(EVR)" ], "offsets": [ [ 331, 346 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T17", "type": "Measurement", "text": [ "C a", "ough levels h" ], "offsets": [ [ 353, 356 ], [ 365, 378 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T18", "type": "Measurement", "text": [ "EVR trough levels" ], "offsets": [ [ 359, 376 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T19", "type": "Scope", "text": [ "tacrolimus(TAC) plus everolimus(EVR)" ], "offsets": [ [ 310, 346 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T13", "type": "Value", "text": [ "within targeted ranges" ], "offsets": [ [ 389, 411 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T20", "type": "Temporal", "text": [ "for at least 6 weeks prior to enrollment" ], "offsets": [ [ 412, 452 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T21", "type": "Reference_point", "text": [ "enrollment" ], "offsets": [ [ 442, 452 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T22", "type": "Scope", "text": [ "TAC and EVR trough levels" ], "offsets": [ [ 351, 376 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T23", "type": "Observation", "text": [ "written informed consent" ], "offsets": [ [ 461, 485 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T24", "type": "Temporal", "text": [ "prior to inclusion" ], "offsets": [ [ 486, 504 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T25", "type": "Reference_point", "text": [ "inclusion" ], "offsets": [ [ 495, 504 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T26", "type": "Person", "text": [ "Liver transplant recipients" ], "offsets": [ [ 506, 533 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T27", "type": "Person", "text": [ "age" ], "offsets": [ [ 557, 560 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T28", "type": "Value", "text": [ "18-65 years" ], "offsets": [ [ 542, 553 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T29", "type": "Procedure", "text": [ "primary liver transplant" ], "offsets": [ [ 566, 590 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T30", "type": "Measurement", "text": [ "Allograft functioning" ], "offsets": [ [ 591, 612 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T31", "type": "Value", "text": [ "acceptable level" ], "offsets": [ [ 619, 635 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T32", "type": "Measurement", "text": [ "AST" ], "offsets": [ [ 654, 657 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T33", "type": "Measurement", "text": [ "ALT" ], "offsets": [ [ 659, 662 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T34", "type": "Measurement", "text": [ "Total Bilirubin" ], "offsets": [ [ 664, 679 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T35", "type": "Value", "text": [ "=3 times ULN" ], "offsets": [ [ 687, 699 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T36", "type": "Temporal", "text": [ "prior to enrollment" ], "offsets": [ [ 700, 719 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T37", "type": "Scope", "text": [ "AST, ALT, Total Bilirubin" ], "offsets": [ [ 654, 679 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T38", "type": "Scope", "text": [ "Allograft functioning at an acceptable level" ], "offsets": [ [ 591, 635 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T39", "type": "Scope", "text": [ "AST, ALT, Total Bilirubin levels =3 times ULN" ], "offsets": [ [ 654, 699 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T40", "type": "Measurement", "text": [ "MDRD eGFR" ], "offsets": [ [ 733, 742 ] ], "normalized": [] }, { "id": "NCT03256864_inc_T41", "type": "Value", "text": [ "= 30 mL/min/1.73m2" ], "offsets": [ [ 743, 761 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03256864_inc_R1", "type": "Has_index", "arg1_id": "NCT03256864_inc_T3", "arg2_id": "NCT03256864_inc_T4", "normalized": [] }, { "id": "NCT03256864_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03256864_inc_T2", "arg2_id": "NCT03256864_inc_T3", "normalized": [] }, { "id": "NCT03256864_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03256864_inc_T8", "arg2_id": "NCT03256864_inc_T7", "normalized": [] }, { "id": "NCT03256864_inc_R4", "type": "Has_negation", "arg1_id": "NCT03256864_inc_T8", "arg2_id": "NCT03256864_inc_T6", "normalized": [] }, { "id": "NCT03256864_inc_R5", "type": "Has_index", "arg1_id": "NCT03256864_inc_T9", "arg2_id": "NCT03256864_inc_T10", "normalized": [] }, { "id": "NCT03256864_inc_R6", "type": "Has_temporal", "arg1_id": "NCT03256864_inc_T8", "arg2_id": "NCT03256864_inc_T9", "normalized": [] }, { "id": "NCT03256864_inc_R7", "type": "Has_multiplier", "arg1_id": "NCT03256864_inc_T19", "arg2_id": "NCT03256864_inc_T14", "normalized": [] }, { "id": "NCT03256864_inc_R8", "type": "Has_index", "arg1_id": "NCT03256864_inc_T20", "arg2_id": "NCT03256864_inc_T21", "normalized": [] }, { "id": "NCT03256864_inc_R9", "type": "Has_value", "arg1_id": "NCT03256864_inc_T22", "arg2_id": "NCT03256864_inc_T13", "normalized": [] }, { "id": "NCT03256864_inc_R10", "type": "Has_temporal", "arg1_id": "NCT03256864_inc_T22", "arg2_id": "NCT03256864_inc_T20", "normalized": [] }, { "id": "NCT03256864_inc_R11", "type": "Has_index", "arg1_id": "NCT03256864_inc_T24", "arg2_id": "NCT03256864_inc_T25", "normalized": [] }, { "id": "NCT03256864_inc_R12", "type": "Has_temporal", "arg1_id": "NCT03256864_inc_T23", "arg2_id": "NCT03256864_inc_T24", "normalized": [] }, { "id": "NCT03256864_inc_R13", "type": "Has_value", "arg1_id": "NCT03256864_inc_T27", "arg2_id": "NCT03256864_inc_T28", "normalized": [] }, { "id": "NCT03256864_inc_R14", "type": "Has_value", "arg1_id": "NCT03256864_inc_T37", "arg2_id": "NCT03256864_inc_T35", "normalized": [] }, { "id": "NCT03256864_inc_R16", "type": "Has_value", "arg1_id": "NCT03256864_inc_T30", "arg2_id": "NCT03256864_inc_T31", "normalized": [] }, { "id": "NCT03256864_inc_R15", "type": "Subsumes", "arg1_id": "NCT03256864_inc_T38", "arg2_id": "NCT03256864_inc_T37", "normalized": [] }, { "id": "NCT03256864_inc_R17", "type": "Has_temporal", "arg1_id": "NCT03256864_inc_T38", "arg2_id": "NCT03256864_inc_T36", "normalized": [] }, { "id": "NCT03256864_inc_R18", "type": "Has_value", "arg1_id": "NCT03256864_inc_T40", "arg2_id": "NCT03256864_inc_T41", "normalized": [] } ]

[ { "id": "NCT03259243_exc_text", "type": "exclusion", "text": [ "Patient with history of allergy in any kind anesthetic drug\nPatient who pregnant\nPatient who sign for single port gynecologic laparoscopic surgery or NOTE surgery\nPatient whom the surgery is withhold or canceled\nPatient whom the surgery is converted to laparotomy\n" ], "offsets": [ [ 0, 264 ] ] } ]

[ { "id": "NCT03259243_exc_T1", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 24, 31 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T2", "type": "Drug", "text": [ "anesthetic drug" ], "offsets": [ [ 44, 59 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T3", "type": "Qualifier", "text": [ "any kind" ], "offsets": [ [ 35, 43 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T4", "type": "Observation", "text": [ "history" ], "offsets": [ [ 13, 20 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T5", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 72, 80 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T6", "type": "Qualifier", "text": [ "single port" ], "offsets": [ [ 102, 113 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T7", "type": "Procedure", "text": [ "gynecologic laparoscopic surgery" ], "offsets": [ [ 114, 146 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T8", "type": "Procedure", "text": [ "NOTE surgery" ], "offsets": [ [ 150, 162 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T9", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 180, 187 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T10", "type": "Observation", "text": [ "withhold" ], "offsets": [ [ 191, 199 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T11", "type": "Observation", "text": [ "canceled" ], "offsets": [ [ 203, 211 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T12", "type": "Scope", "text": [ "withhold or canceled" ], "offsets": [ [ 191, 211 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T13", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 229, 236 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T14", "type": "Observation", "text": [ "converted to" ], "offsets": [ [ 240, 252 ] ], "normalized": [] }, { "id": "NCT03259243_exc_T15", "type": "Procedure", "text": [ "laparotomy" ], "offsets": [ [ 253, 263 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03259243_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03259243_exc_T2", "arg2_id": "NCT03259243_exc_T3", "normalized": [] }, { "id": "NCT03259243_exc_R2", "type": "AND", "arg1_id": "NCT03259243_exc_T1", "arg2_id": "NCT03259243_exc_T2", "normalized": [] }, { "id": "NCT03259243_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03259243_exc_T1", "arg2_id": "NCT03259243_exc_T4", "normalized": [] }, { "id": "NCT03259243_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03259243_exc_T7", "arg2_id": "NCT03259243_exc_T6", "normalized": [] }, { "id": "NCT03259243_exc_R5", "type": "Has_scope", "arg1_id": "NCT03259243_exc_T9", "arg2_id": "NCT03259243_exc_T12", "normalized": [] }, { "id": "NCT03259243_exc_R6", "type": "AND", "arg1_id": "NCT03259243_exc_T14", "arg2_id": "NCT03259243_exc_T15", "normalized": [] } ]

[ { "id": "NCT03259243_inc_text", "type": "inclusion", "text": [ "Patient who undergoing gynecologic laparoscopic surgery\nPatient who agrees to participate in this study\nPatient able to speak and understand Thai\nPatient able to complete the questionnaire\n" ], "offsets": [ [ 0, 189 ] ] } ]

[ { "id": "NCT03259243_inc_T1", "type": "Procedure", "text": [ "gynecologic laparoscopic surgery" ], "offsets": [ [ 23, 55 ] ], "normalized": [] }, { "id": "NCT03259243_inc_T2", "type": "Observation", "text": [ "able to complete the questionnaire" ], "offsets": [ [ 154, 188 ] ], "normalized": [] }, { "id": "NCT03259243_inc_T3", "type": "Observation", "text": [ "agrees to participate in this study" ], "offsets": [ [ 68, 103 ] ], "normalized": [] }, { "id": "NCT03259243_inc_T5", "type": "Observation", "text": [ "able to speak and understand Thai" ], "offsets": [ [ 112, 145 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT03260790_exc_text", "type": "exclusion", "text": [ "Research exemption requested\nHistory of PCV-13 vaccination\nHistory of cochlear implant\nCerebrospinal Fluid (CSF) leak\nCongestive Heart Failure (CHF)\nDiabetes Mellitus (DM)\nChronic Kidney Disease (CKD)\nHuman Immunodeficiency Virus (HIV)\nCommon Variable Immune Deficiency (CVID)\nPatients who have received the PPSV23 vaccine in the last 5 years\nWomen who are pregnant will also be excluded from the study by performing 2 point of care urine pregnancy tests ( prior to vaccinations)\n" ], "offsets": [ [ 0, 480 ] ] } ]

[ { "id": "NCT03260790_exc_T1", "type": "Observation", "text": [ "Research exemption requested" ], "offsets": [ [ 0, 28 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T2", "type": "Observation", "text": [ "History" ], "offsets": [ [ 29, 36 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T3", "type": "Procedure", "text": [ "PCV-13 vaccination" ], "offsets": [ [ 40, 58 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T4", "type": "Observation", "text": [ "History" ], "offsets": [ [ 59, 66 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T5", "type": "Device", "text": [ "cochlear implant" ], "offsets": [ [ 70, 86 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T6", "type": "Condition", "text": [ "Cerebrospinal Fluid (CSF) leak" ], "offsets": [ [ 87, 117 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T7", "type": "Condition", "text": [ "Congestive Heart Failure (CHF)" ], "offsets": [ [ 118, 148 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T8", "type": "Condition", "text": [ "Diabetes Mellitus (DM)" ], "offsets": [ [ 149, 171 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T9", "type": "Condition", "text": [ "Chronic Kidney Disease (CKD)" ], "offsets": [ [ 172, 200 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T10", "type": "Condition", "text": [ "Human Immunodeficiency Virus (HIV)" ], "offsets": [ [ 201, 235 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T11", "type": "Condition", "text": [ "Common Variable Immune Deficiency (CVID)" ], "offsets": [ [ 236, 276 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T12", "type": "Drug", "text": [ "PPSV23 vaccine" ], "offsets": [ [ 308, 322 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T13", "type": "Temporal", "text": [ "in the last 5 years" ], "offsets": [ [ 323, 342 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T14", "type": "Person", "text": [ "Women" ], "offsets": [ [ 343, 348 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T15", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 357, 365 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T16", "type": "Procedure", "text": [ "point of care urine pregnancy tests" ], "offsets": [ [ 419, 454 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T17", "type": "Multiplier", "text": [ "2" ], "offsets": [ [ 417, 418 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T18", "type": "Temporal", "text": [ "prior to vaccinations" ], "offsets": [ [ 457, 478 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T19", "type": "Procedure", "text": [ "vaccinations" ], "offsets": [ [ 466, 478 ] ], "normalized": [] }, { "id": "NCT03260790_exc_T20", "type": "Reference_point", "text": [ "vaccinations" ], "offsets": [ [ 466, 478 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03260790_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03260790_exc_T3", "arg2_id": "NCT03260790_exc_T2", "normalized": [] }, { "id": "NCT03260790_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03260790_exc_T5", "arg2_id": "NCT03260790_exc_T4", "normalized": [] }, { "id": "NCT03260790_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03260790_exc_T12", "arg2_id": "NCT03260790_exc_T13", "normalized": [] }, { "id": "NCT03260790_exc_R4", "type": "Has_multiplier", "arg1_id": "NCT03260790_exc_T16", "arg2_id": "NCT03260790_exc_T17", "normalized": [] }, { "id": "NCT03260790_exc_R5", "type": "Has_index", "arg1_id": "NCT03260790_exc_T18", "arg2_id": "NCT03260790_exc_T20", "normalized": [] }, { "id": "NCT03260790_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03260790_exc_T16", "arg2_id": "NCT03260790_exc_T18", "normalized": [] } ]

[ { "id": "NCT03260790_inc_text", "type": "inclusion", "text": [ "Diagnosis of asthma\n" ], "offsets": [ [ 0, 20 ] ] } ]

[ { "id": "NCT03260790_inc_T1", "type": "Condition", "text": [ "asthma" ], "offsets": [ [ 13, 19 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT03260881_exc_text", "type": "exclusion", "text": [ "Patients with a personal or family history of medullary thyroid carcinoma or patients with Multiple Endocrine Neoplasia syndrome type 2\nPatients with a prior serious hypersensitivity reaction to liraglutide\nOther contra-indications to liraglutide in accordance with risks and safety information included in the latest updated prescribing information\nType 1 diabetes, as defined by ADA criteria\nCurrent use of other GLP-1A, dipeptidyl peptidase 4 (DPP4) or Sodium Glucose transporters 2 (SGLT2) inhibitors, thiazolidinediones (TZDs), pramlintide and fixed prandial insulin.\nPatients with unstable CAD, assessed by the Cardiology team and defined as new onset angina, rest angina, rapidly increasing or crescendo angina\nHistory of diabetic ketoacidosis, pancreas or beta-cell transplantation, or diabetes secondary to pancreatitis or pancreatectomy; acute or chronic infective diseases, cancer or chemotherapy, history of pulmonary, renal or liver diseases, and drug abuse\nPatients with chronic and acute inflammatory conditions such as sepsis, rheumatoid arthritis, ectopic dermatitis, asthma, ulcerative colitis.\nCurrent use of systemic corticosteroids in the 3 months prior this study.\nPregnant or breast-feeding women\nFemales of childbearing potential who are not using adequate contraceptive methods (as required by local law or practice)\n" ], "offsets": [ [ 0, 1342 ] ] } ]

[ { "id": "NCT03260881_exc_T1", "type": "Observation", "text": [ "personal", "history" ], "offsets": [ [ 16, 24 ], [ 35, 42 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T2", "type": "Observation", "text": [ "family history" ], "offsets": [ [ 28, 42 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T3", "type": "Condition", "text": [ "medullary thyroid carcinoma" ], "offsets": [ [ 46, 73 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T4", "type": "Condition", "text": [ "Multiple Endocrine Neoplasia syndrome type 2" ], "offsets": [ [ 91, 135 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T5", "type": "Scope", "text": [ "personal or family history" ], "offsets": [ [ 16, 42 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T6", "type": "Scope", "text": [ "medullary thyroid carcinoma or patients with Multiple Endocrine Neoplasia syndrome type 2" ], "offsets": [ [ 46, 135 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T7", "type": "Condition", "text": [ "hypersensitivity reaction" ], "offsets": [ [ 166, 191 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T8", "type": "Drug", "text": [ "liraglutide" ], "offsets": [ [ 195, 206 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T9", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 152, 157 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T10", "type": "Qualifier", "text": [ "serious" ], "offsets": [ [ 158, 165 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T11", "type": "Drug", "text": [ "liraglutide" ], "offsets": [ [ 235, 246 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T12", "type": "Condition", "text": [ "contra-indications" ], "offsets": [ [ 213, 231 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T13", "type": "Qualifier", "text": [ "Other" ], "offsets": [ [ 207, 212 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T14", "type": "Condition", "text": [ "Type 1 diabetes" ], "offsets": [ [ 350, 365 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T15", "type": "Qualifier", "text": [ "ADA criteria" ], "offsets": [ [ 381, 393 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T16", "type": "Drug", "text": [ "GLP-1A" ], "offsets": [ [ 415, 421 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T17", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 409, 414 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T18", "type": "Drug", "text": [ "ptidyl peptidase 4 (DPP4) or", "bitors, th" ], "offsets": [ [ 427, 455 ], [ 498, 508 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T19", "type": "Drug", "text": [ "Sodium Glucose transporters 2 (SGLT2) inhibitors" ], "offsets": [ [ 456, 504 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T20", "type": "Drug", "text": [ "thiazolidinediones (TZDs)" ], "offsets": [ [ 506, 531 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T21", "type": "Drug", "text": [ "pramlintide" ], "offsets": [ [ 533, 544 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T22", "type": "Drug", "text": [ "prandial insulin" ], "offsets": [ [ 555, 571 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T23", "type": "Condition", "text": [ "unstable CAD" ], "offsets": [ [ 587, 599 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T24", "type": "Condition", "text": [ "new onset angina" ], "offsets": [ [ 648, 664 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T25", "type": "Condition", "text": [ "rest angina" ], "offsets": [ [ 666, 677 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T26", "type": "Condition", "text": [ "ly increasing or c", "a\nHist" ], "offsets": [ [ 684, 702 ], [ 716, 722 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T27", "type": "Condition", "text": [ "crescendo angina" ], "offsets": [ [ 701, 717 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T28", "type": "Scope", "text": [ "new onset angina, rest angina, rapidly increasing or crescendo angina" ], "offsets": [ [ 648, 717 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T29", "type": "Condition", "text": [ "diabetic ketoacidosis" ], "offsets": [ [ 729, 750 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T30", "type": "Procedure", "text": [ "as or be", "lantation, or d" ], "offsets": [ [ 758, 766 ], [ 780, 795 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T31", "type": "Procedure", "text": [ "beta-cell transplantation" ], "offsets": [ [ 764, 789 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T32", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 794, 802 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T33", "type": "Procedure", "text": [ "pancreatitis" ], "offsets": [ [ 816, 828 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T34", "type": "Procedure", "text": [ "pancreatectomy" ], "offsets": [ [ 832, 846 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T35", "type": "Scope", "text": [ "pancreatitis or pancreatectomy" ], "offsets": [ [ 816, 846 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T36", "type": "Qualifier", "text": [ "secondary to" ], "offsets": [ [ 803, 815 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T37", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 848, 853 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T38", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 857, 864 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T39", "type": "Condition", "text": [ "infective diseases" ], "offsets": [ [ 865, 883 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T40", "type": "Condition", "text": [ "cancer" ], "offsets": [ [ 885, 891 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T41", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 895, 907 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T42", "type": "Condition", "text": [ "liver diseases" ], "offsets": [ [ 940, 954 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T43", "type": "Condition", "text": [ "or li", "es, and" ], "offsets": [ [ 937, 942 ], [ 952, 959 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T44", "type": "Condition", "text": [ "ary, rena", "es, and" ], "offsets": [ [ 926, 935 ], [ 952, 959 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T45", "type": "Condition", "text": [ "drug abuse" ], "offsets": [ [ 960, 970 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T46", "type": "Scope", "text": [ "acute or chronic" ], "offsets": [ [ 848, 864 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T47", "type": "Observation", "text": [ "History" ], "offsets": [ [ 718, 725 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T48", "type": "Scope", "text": [ "diabetic ketoacidosis, pancreas or beta-cell transplantation, or diabetes secondary to pancreatitis or pancreatectomy; acute or chronic infective diseases, cancer or chemotherapy, history of pulmonary, renal or liver diseases, and drug abuse" ], "offsets": [ [ 729, 970 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T49", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 985, 992 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T50", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 997, 1002 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T51", "type": "Condition", "text": [ "inflammatory conditions" ], "offsets": [ [ 1003, 1026 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T52", "type": "Condition", "text": [ "sepsis" ], "offsets": [ [ 1035, 1041 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T53", "type": "Condition", "text": [ "rheumatoid arthritis" ], "offsets": [ [ 1043, 1063 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T54", "type": "Condition", "text": [ "ectopic dermatitis" ], "offsets": [ [ 1065, 1083 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T55", "type": "Condition", "text": [ "asthma" ], "offsets": [ [ 1085, 1091 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T56", "type": "Condition", "text": [ "ulcerative colitis" ], "offsets": [ [ 1093, 1111 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T57", "type": "Scope", "text": [ "sepsis, rheumatoid arthritis, ectopic dermatitis, asthma, ulcerative colitis" ], "offsets": [ [ 1035, 1111 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T58", "type": "Scope", "text": [ "chronic and acute" ], "offsets": [ [ 985, 1002 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T59", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 1113, 1120 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T60", "type": "Drug", "text": [ "systemic corticosteroids" ], "offsets": [ [ 1128, 1152 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T61", "type": "Temporal", "text": [ "in the 3 months prior this study" ], "offsets": [ [ 1153, 1185 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T62", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 1187, 1195 ] ], "normalized": [] }, { "id": "NCT03260881_exc_T63", "type": "Condition", "text": [ "breast-feeding women" ], "offsets": [ [ 1199, 1219 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03260881_exc_R1", "type": "Has_scope", "arg1_id": "NCT03260881_exc_T6", "arg2_id": "NCT03260881_exc_T5", "normalized": [] }, { "id": "NCT03260881_exc_R2", "type": "AND", "arg1_id": "NCT03260881_exc_T7", "arg2_id": "NCT03260881_exc_T8", "normalized": [] }, { "id": "NCT03260881_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03260881_exc_T7", "arg2_id": "NCT03260881_exc_T10", "normalized": [] }, { "id": "NCT03260881_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03260881_exc_T7", "arg2_id": "NCT03260881_exc_T9", "normalized": [] }, { "id": "NCT03260881_exc_R5", "type": "AND", "arg1_id": "NCT03260881_exc_T12", "arg2_id": "NCT03260881_exc_T11", "normalized": [] }, { "id": "NCT03260881_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03260881_exc_T12", "arg2_id": "NCT03260881_exc_T13", "normalized": [] }, { "id": "NCT03260881_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03260881_exc_T14", "arg2_id": "NCT03260881_exc_T15", "normalized": [] }, { "id": "NCT03260881_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03260881_exc_T16", "arg2_id": "NCT03260881_exc_T17", "normalized": [] }, { "id": "NCT03260881_exc_R9", "type": "Subsumes", "arg1_id": "NCT03260881_exc_T23", "arg2_id": "NCT03260881_exc_T28", "normalized": [] }, { "id": "NCT03260881_exc_R10", "type": "Has_scope", "arg1_id": "NCT03260881_exc_T36", "arg2_id": "NCT03260881_exc_T35", "normalized": [] }, { "id": "NCT03260881_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT03260881_exc_T32", "arg2_id": "NCT03260881_exc_T36", "normalized": [] }, { "id": "NCT03260881_exc_R12", "type": "Has_scope", "arg1_id": "NCT03260881_exc_T39", "arg2_id": "NCT03260881_exc_T46", "normalized": [] }, { "id": "NCT03260881_exc_R13", "type": "Has_temporal", "arg1_id": "NCT03260881_exc_T48", "arg2_id": "NCT03260881_exc_T47", "normalized": [] }, { "id": "NCT03260881_exc_R14", "type": "Subsumes", "arg1_id": "NCT03260881_exc_T51", "arg2_id": "NCT03260881_exc_T57", "normalized": [] }, { "id": "NCT03260881_exc_R15", "type": "Has_scope", "arg1_id": "NCT03260881_exc_T51", "arg2_id": "NCT03260881_exc_T58", "normalized": [] }, { "id": "NCT03260881_exc_R16", "type": "Has_temporal", "arg1_id": "NCT03260881_exc_T60", "arg2_id": "NCT03260881_exc_T59", "normalized": [] }, { "id": "NCT03260881_exc_R17", "type": "Has_temporal", "arg1_id": "NCT03260881_exc_T60", "arg2_id": "NCT03260881_exc_T61", "normalized": [] } ]

[ { "id": "NCT03260881_inc_text", "type": "inclusion", "text": [ "T2DM as defined by American Diabetes Association (ADA) criteria\nAdult patients with T2DM who are indicated to receive liraglutide, not as first-line therapy, in addition to diet and exercise to improve glycemic control\nHemoglobin A1c (HbA1c) = 9%\nAge = 18 years old\nBody mass index (BMI) = 27 Kg/m2 and/or waist circumference = 102 cm (40 inches) in men and 88 cm (35 inches) in women, respectively.\nClinically and angiographically stable CAD who requires CABG as part of the standard medical care, as CAD does not represent a contraindication for using liraglutide. The stability of the CAD further warranties that study patients will not be exposed to higher risk by using liraglutide\n" ], "offsets": [ [ 0, 687 ] ] } ]

[ { "id": "NCT03260881_inc_T1", "type": "Condition", "text": [ "T2DM" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T2", "type": "Qualifier", "text": [ "American Diabetes Association (ADA) criteria" ], "offsets": [ [ 19, 63 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T3", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 64, 69 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T4", "type": "Condition", "text": [ "T2DM" ], "offsets": [ [ 84, 88 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T5", "type": "Drug", "text": [ "liraglutide" ], "offsets": [ [ 118, 129 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T6", "type": "Mood", "text": [ "indicated to receive" ], "offsets": [ [ 97, 117 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T7", "type": "Qualifier", "text": [ "first-line therapy" ], "offsets": [ [ 138, 156 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T8", "type": "Negation", "text": [ "not" ], "offsets": [ [ 131, 134 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T10", "type": "Measurement", "text": [ "Hemoglobin A1c (HbA1c)" ], "offsets": [ [ 219, 241 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T11", "type": "Value", "text": [ "= 9%" ], "offsets": [ [ 242, 246 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T12", "type": "Person", "text": [ "Age" ], "offsets": [ [ 247, 250 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T13", "type": "Value", "text": [ "= 18 years old" ], "offsets": [ [ 251, 265 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T14", "type": "Measurement", "text": [ "Body mass index (BMI)" ], "offsets": [ [ 266, 287 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T15", "type": "Value", "text": [ "= 27 Kg/m2" ], "offsets": [ [ 288, 298 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T16", "type": "Measurement", "text": [ "waist circumference" ], "offsets": [ [ 306, 325 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T17", "type": "Value", "text": [ "= 102 cm" ], "offsets": [ [ 326, 334 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T18", "type": "Value", "text": [ "40 inches" ], "offsets": [ [ 336, 345 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T19", "type": "Person", "text": [ "men" ], "offsets": [ [ 350, 353 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T20", "type": "Value", "text": [ "88 cm" ], "offsets": [ [ 358, 363 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T21", "type": "Value", "text": [ "35 inches" ], "offsets": [ [ 365, 374 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T22", "type": "Person", "text": [ "women" ], "offsets": [ [ 379, 384 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T23", "type": "Scope", "text": [ "= 102 cm (40 inches) in men and 88 cm (35 inches) in women" ], "offsets": [ [ 326, 384 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T24", "type": "Qualifier", "text": [ "angiographically stable" ], "offsets": [ [ 415, 438 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T25", "type": "Condition", "text": [ "CAD" ], "offsets": [ [ 439, 442 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T26", "type": "Procedure", "text": [ "CABG" ], "offsets": [ [ 456, 460 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T27", "type": "Mood", "text": [ "requires" ], "offsets": [ [ 447, 455 ] ], "normalized": [] }, { "id": "NCT03260881_inc_T28", "type": "Qualifier", "text": [ "cally and", "e CAD" ], "offsets": [ [ 405, 414 ], [ 437, 442 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03260881_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03260881_inc_T1", "arg2_id": "NCT03260881_inc_T2", "normalized": [] }, { "id": "NCT03260881_inc_R2", "type": "Has_negation", "arg1_id": "NCT03260881_inc_T7", "arg2_id": "NCT03260881_inc_T8", "normalized": [] }, { "id": "NCT03260881_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03260881_inc_T5", "arg2_id": "NCT03260881_inc_T7", "normalized": [] }, { "id": "NCT03260881_inc_R4", "type": "Has_mood", "arg1_id": "NCT03260881_inc_T5", "arg2_id": "NCT03260881_inc_T6", "normalized": [] }, { "id": "NCT03260881_inc_R5", "type": "Has_value", "arg1_id": "NCT03260881_inc_T10", "arg2_id": "NCT03260881_inc_T11", "normalized": [] }, { "id": "NCT03260881_inc_R6", "type": "Has_value", "arg1_id": "NCT03260881_inc_T12", "arg2_id": "NCT03260881_inc_T13", "normalized": [] }, { "id": "NCT03260881_inc_R7", "type": "Subsumes", "arg1_id": "NCT03260881_inc_T17", "arg2_id": "NCT03260881_inc_T18", "normalized": [] }, { "id": "NCT03260881_inc_R8", "type": "Subsumes", "arg1_id": "NCT03260881_inc_T20", "arg2_id": "NCT03260881_inc_T21", "normalized": [] }, { "id": "NCT03260881_inc_R9", "type": "Has_value", "arg1_id": "NCT03260881_inc_T22", "arg2_id": "NCT03260881_inc_T20", "normalized": [] }, { "id": "NCT03260881_inc_R10", "type": "Has_value", "arg1_id": "NCT03260881_inc_T19", "arg2_id": "NCT03260881_inc_T17", "normalized": [] }, { "id": "NCT03260881_inc_R11", "type": "Has_scope", "arg1_id": "NCT03260881_inc_T16", "arg2_id": "NCT03260881_inc_T23", "normalized": [] }, { "id": "NCT03260881_inc_R12", "type": "Has_value", "arg1_id": "NCT03260881_inc_T14", "arg2_id": "NCT03260881_inc_T15", "normalized": [] }, { "id": "NCT03260881_inc_R13", "type": "Has_mood", "arg1_id": "NCT03260881_inc_T26", "arg2_id": "NCT03260881_inc_T27", "normalized": [] }, { "id": "NCT03260881_inc_R14", "type": "Has_qualifier", "arg1_id": "NCT03260881_inc_T25", "arg2_id": "NCT03260881_inc_T24", "normalized": [] }, { "id": "NCT03260881_inc_R15", "type": "Has_qualifier", "arg1_id": "NCT03260881_inc_T25", "arg2_id": "NCT03260881_inc_T28", "normalized": [] } ]

[ { "id": "NCT03262038_exc_text", "type": "exclusion", "text": [ "Inability to use verbal or pictorial pain scoring scales\nhypersensitivity to selective 5-HT receptor antagonists\ndiagnosed congenital long QT syndrome\nsevere hepatic impairment\npregnancy or nursing mothers\n" ], "offsets": [ [ 0, 206 ] ] } ]

[ { "id": "NCT03262038_exc_T1", "type": "Procedure", "text": [ "pictorial pain scoring scales" ], "offsets": [ [ 27, 56 ] ], "normalized": [] }, { "id": "NCT03262038_exc_T2", "type": "Procedure", "text": [ "verbal", "pain scoring scales" ], "offsets": [ [ 17, 23 ], [ 37, 56 ] ], "normalized": [] }, { "id": "NCT03262038_exc_T3", "type": "Condition", "text": [ "Inability" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT03262038_exc_T4", "type": "Scope", "text": [ "verbal or pictorial pain scoring scales" ], "offsets": [ [ 17, 56 ] ], "normalized": [] }, { "id": "NCT03262038_exc_T5", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 57, 73 ] ], "normalized": [] }, { "id": "NCT03262038_exc_T6", "type": "Drug", "text": [ "selective 5-HT receptor antagonists" ], "offsets": [ [ 77, 112 ] ], "normalized": [] }, { "id": "NCT03262038_exc_T8", "type": "Condition", "text": [ "congenital long QT syndrome" ], "offsets": [ [ 123, 150 ] ], "normalized": [] }, { "id": "NCT03262038_exc_T7", "type": "Condition", "text": [ "hepatic impairment" ], "offsets": [ [ 158, 176 ] ], "normalized": [] }, { "id": "NCT03262038_exc_T9", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 151, 157 ] ], "normalized": [] }, { "id": "NCT03262038_exc_T10", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 177, 186 ] ], "normalized": [] }, { "id": "NCT03262038_exc_T11", "type": "Condition", "text": [ "nursing" ], "offsets": [ [ 190, 197 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03262038_exc_R1", "type": "Has_scope", "arg1_id": "NCT03262038_exc_T3", "arg2_id": "NCT03262038_exc_T4", "normalized": [] }, { "id": "NCT03262038_exc_R2", "type": "AND", "arg1_id": "NCT03262038_exc_T5", "arg2_id": "NCT03262038_exc_T6", "normalized": [] }, { "id": "NCT03262038_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03262038_exc_T7", "arg2_id": "NCT03262038_exc_T9", "normalized": [] } ]

[ { "id": "NCT03262038_inc_text", "type": "inclusion", "text": [ "3-17 years\nweight </= 100kg\nscheduled for urologic or orthopedic procedure necessitating intrathecal morphine\nability to use verbal or pictorial pain assessment tools and techniques\ninformed consent and (if applicable) assent\n" ], "offsets": [ [ 0, 226 ] ] } ]

[ { "id": "NCT03262038_inc_T1", "type": "Person", "text": [ "3-17 years" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT03262038_inc_T2", "type": "Value", "text": [ "3-17 years" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT03262038_inc_T3", "type": "Measurement", "text": [ "weight" ], "offsets": [ [ 11, 17 ] ], "normalized": [] }, { "id": "NCT03262038_inc_T4", "type": "Value", "text": [ "</= 100kg" ], "offsets": [ [ 18, 27 ] ], "normalized": [] }, { "id": "NCT03262038_inc_T5", "type": "Procedure", "text": [ "orthopedic procedure" ], "offsets": [ [ 54, 74 ] ], "normalized": [] }, { "id": "NCT03262038_inc_T6", "type": "Procedure", "text": [ "ologic o", "ocedure n" ], "offsets": [ [ 44, 52 ], [ 67, 76 ] ], "normalized": [] }, { "id": "NCT03262038_inc_T7", "type": "Drug", "text": [ "morphine" ], "offsets": [ [ 101, 109 ] ], "normalized": [] }, { "id": "NCT03262038_inc_T8", "type": "Qualifier", "text": [ "intrathecal" ], "offsets": [ [ 89, 100 ] ], "normalized": [] }, { "id": "NCT03262038_inc_T9", "type": "Scope", "text": [ "urologic or orthopedic procedure" ], "offsets": [ [ 42, 74 ] ], "normalized": [] }, { "id": "NCT03262038_inc_T10", "type": "Condition", "text": [ "ability" ], "offsets": [ [ 110, 117 ] ], "normalized": [] }, { "id": "NCT03262038_inc_T11", "type": "Procedure", "text": [ "pictorial pain assessment tools and techniques" ], "offsets": [ [ 135, 181 ] ], "normalized": [] }, { "id": "NCT03262038_inc_T12", "type": "Procedure", "text": [ "bal or", "n assessment tools and techniques\nin" ], "offsets": [ [ 128, 134 ], [ 148, 184 ] ], "normalized": [] }, { "id": "NCT03262038_inc_T13", "type": "Scope", "text": [ "verbal or pictorial pain assessment tools and techniques" ], "offsets": [ [ 125, 181 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03262038_inc_R1", "type": "Has_value", "arg1_id": "NCT03262038_inc_T3", "arg2_id": "NCT03262038_inc_T4", "normalized": [] }, { "id": "NCT03262038_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03262038_inc_T7", "arg2_id": "NCT03262038_inc_T8", "normalized": [] }, { "id": "NCT03262038_inc_R3", "type": "AND", "arg1_id": "NCT03262038_inc_T9", "arg2_id": "NCT03262038_inc_T7", "normalized": [] }, { "id": "NCT03262038_inc_R4", "type": "Has_scope", "arg1_id": "NCT03262038_inc_T10", "arg2_id": "NCT03262038_inc_T13", "normalized": [] } ]

[ { "id": "NCT03263481_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT03263481_inc_text", "type": "inclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT03264911_exc_text", "type": "exclusion", "text": [ "Hypersensitivity to B-lactams\nconcomitant disease which must be treated with antibiotics\nchronic disease-Immunocompromised\nAntibiotics within 72 h\nhistory of ARF,scarlet fever,impetigo,acute glomerulonephritis\nFamily history of ARF\nComplicated pharyngitis\n" ], "offsets": [ [ 0, 256 ] ] } ]

[ { "id": "NCT03264911_exc_T1", "type": "Drug", "text": [ "B-lactams" ], "offsets": [ [ 20, 29 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T2", "type": "Condition", "text": [ "Hypersensitivity" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T3", "type": "Temporal", "text": [ "concomitant" ], "offsets": [ [ 30, 41 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T4", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 42, 49 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T5", "type": "Drug", "text": [ "antibiotics" ], "offsets": [ [ 77, 88 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T6", "type": "Procedure", "text": [ "treated" ], "offsets": [ [ 64, 71 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T7", "type": "Condition", "text": [ "Immunocompromised" ], "offsets": [ [ 105, 122 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T8", "type": "Drug", "text": [ "Antibiotics" ], "offsets": [ [ 123, 134 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T9", "type": "Temporal", "text": [ "within 72 h" ], "offsets": [ [ 135, 146 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T10", "type": "Condition", "text": [ "ARF" ], "offsets": [ [ 158, 161 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T11", "type": "Observation", "text": [ "history" ], "offsets": [ [ 147, 154 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T12", "type": "Condition", "text": [ "scarlet fever" ], "offsets": [ [ 162, 175 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T13", "type": "Condition", "text": [ "impetigo" ], "offsets": [ [ 176, 184 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T14", "type": "Condition", "text": [ "acute glomerulonephritis" ], "offsets": [ [ 185, 209 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T15", "type": "Scope", "text": [ "ARF,scarlet fever,impetigo,acute glomerulonephritis" ], "offsets": [ [ 158, 209 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T16", "type": "Condition", "text": [ "ARF" ], "offsets": [ [ 228, 231 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T17", "type": "Observation", "text": [ "Family history" ], "offsets": [ [ 210, 224 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T18", "type": "Condition", "text": [ "pharyngitis" ], "offsets": [ [ 244, 255 ] ], "normalized": [] }, { "id": "NCT03264911_exc_T19", "type": "Qualifier", "text": [ "Complicated" ], "offsets": [ [ 232, 243 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03264911_exc_R1", "type": "AND", "arg1_id": "NCT03264911_exc_T2", "arg2_id": "NCT03264911_exc_T1", "normalized": [] }, { "id": "NCT03264911_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03264911_exc_T4", "arg2_id": "NCT03264911_exc_T3", "normalized": [] }, { "id": "NCT03264911_exc_R3", "type": "AND", "arg1_id": "NCT03264911_exc_T6", "arg2_id": "NCT03264911_exc_T5", "normalized": [] }, { "id": "NCT03264911_exc_R4", "type": "AND", "arg1_id": "NCT03264911_exc_T4", "arg2_id": "NCT03264911_exc_T6", "normalized": [] }, { "id": "NCT03264911_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03264911_exc_T8", "arg2_id": "NCT03264911_exc_T9", "normalized": [] }, { "id": "NCT03264911_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03264911_exc_T15", "arg2_id": "NCT03264911_exc_T11", "normalized": [] }, { "id": "NCT03264911_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03264911_exc_T18", "arg2_id": "NCT03264911_exc_T19", "normalized": [] } ]

[ { "id": "NCT03264911_inc_text", "type": "inclusion", "text": [ "3 -15 years old\nClinical symptoms suggestive of pharyngitis with MC Isaac score =3\nRapid-antigen detection test (RADT) positive for GAS-\nSigned informed parental/patient consent form\n" ], "offsets": [ [ 0, 183 ] ] } ]

[ { "id": "NCT03264911_inc_T1", "type": "Value", "text": [ "3 -15 years" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT03264911_inc_T2", "type": "Person", "text": [ "old" ], "offsets": [ [ 12, 15 ] ], "normalized": [] }, { "id": "NCT03264911_inc_T3", "type": "Measurement", "text": [ "RADT" ], "offsets": [ [ 113, 117 ] ], "normalized": [] }, { "id": "NCT03264911_inc_T4", "type": "Condition", "text": [ "pharyngitis" ], "offsets": [ [ 48, 59 ] ], "normalized": [] }, { "id": "NCT03264911_inc_T5", "type": "Mood", "text": [ "Clinical symptoms suggestive of" ], "offsets": [ [ 16, 47 ] ], "normalized": [] }, { "id": "NCT03264911_inc_T6", "type": "Measurement", "text": [ "MC Isaac score" ], "offsets": [ [ 65, 79 ] ], "normalized": [] }, { "id": "NCT03264911_inc_T7", "type": "Value", "text": [ "=3" ], "offsets": [ [ 80, 82 ] ], "normalized": [] }, { "id": "NCT03264911_inc_T8", "type": "Measurement", "text": [ "Rapid-antigen detection test" ], "offsets": [ [ 83, 111 ] ], "normalized": [] }, { "id": "NCT03264911_inc_T9", "type": "Value", "text": [ "positive" ], "offsets": [ [ 119, 127 ] ], "normalized": [] }, { "id": "NCT03264911_inc_T10", "type": "Qualifier", "text": [ "GAS-" ], "offsets": [ [ 132, 136 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03264911_inc_R1", "type": "Has_value", "arg1_id": "NCT03264911_inc_T2", "arg2_id": "NCT03264911_inc_T1", "normalized": [] }, { "id": "NCT03264911_inc_R2", "type": "Has_value", "arg1_id": "NCT03264911_inc_T6", "arg2_id": "NCT03264911_inc_T7", "normalized": [] }, { "id": "NCT03264911_inc_R3", "type": "Has_mood", "arg1_id": "NCT03264911_inc_T4", "arg2_id": "NCT03264911_inc_T5", "normalized": [] }, { "id": "NCT03264911_inc_R4", "type": "AND", "arg1_id": "NCT03264911_inc_T4", "arg2_id": "NCT03264911_inc_T6", "normalized": [] }, { "id": "NCT03264911_inc_R5", "type": "Subsumes", "arg1_id": "NCT03264911_inc_T8", "arg2_id": "NCT03264911_inc_T3", "normalized": [] }, { "id": "NCT03264911_inc_R6", "type": "Has_value", "arg1_id": "NCT03264911_inc_T8", "arg2_id": "NCT03264911_inc_T9", "normalized": [] }, { "id": "NCT03264911_inc_R7", "type": "Has_qualifier", "arg1_id": "NCT03264911_inc_T9", "arg2_id": "NCT03264911_inc_T10", "normalized": [] } ]

[ { "id": "NCT03275584_exc_text", "type": "exclusion", "text": [ "Pregnant women\nClaustrophobic patient unable to undergo the examination\nBreastfeeding women unwilling to temporarily stop breastfeeding\nPatient with contra-indication to: dipyridamole, aminophylline, dobutamine or exercise stress test (depending on the method of cardiovascular stress test chosen)\n" ], "offsets": [ [ 0, 298 ] ] } ]

[ { "id": "NCT03275584_exc_T1", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03275584_exc_T2", "type": "Person", "text": [ "women" ], "offsets": [ [ 9, 14 ] ], "normalized": [] }, { "id": "NCT03275584_exc_T3", "type": "Condition", "text": [ "Claustrophobic" ], "offsets": [ [ 15, 29 ] ], "normalized": [] }, { "id": "NCT03275584_exc_T4", "type": "Negation", "text": [ "unable" ], "offsets": [ [ 38, 44 ] ], "normalized": [] }, { "id": "NCT03275584_exc_T5", "type": "Procedure", "text": [ "examination" ], "offsets": [ [ 60, 71 ] ], "normalized": [] }, { "id": "NCT03275584_exc_T7", "type": "Condition", "text": [ "contra-indication" ], "offsets": [ [ 149, 166 ] ], "normalized": [] }, { "id": "NCT03275584_exc_T8", "type": "Drug", "text": [ "dipyridamole" ], "offsets": [ [ 171, 183 ] ], "normalized": [] }, { "id": "NCT03275584_exc_T9", "type": "Drug", "text": [ "aminophylline" ], "offsets": [ [ 185, 198 ] ], "normalized": [] }, { "id": "NCT03275584_exc_T10", "type": "Drug", "text": [ "dobutamine" ], "offsets": [ [ 200, 210 ] ], "normalized": [] }, { "id": "NCT03275584_exc_T11", "type": "Procedure", "text": [ "exercise stress test" ], "offsets": [ [ 214, 234 ] ], "normalized": [] }, { "id": "NCT03275584_exc_T13", "type": "Scope", "text": [ "dipyridamole, aminophylline, dobutamine or exercise stress test" ], "offsets": [ [ 171, 234 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03275584_exc_R1", "type": "Has_negation", "arg1_id": "NCT03275584_exc_T5", "arg2_id": "NCT03275584_exc_T4", "normalized": [] }, { "id": "NCT03275584_exc_R2", "type": "AND", "arg1_id": "NCT03275584_exc_T3", "arg2_id": "NCT03275584_exc_T5", "normalized": [] }, { "id": "NCT03275584_exc_R3", "type": "Subsumes", "arg1_id": "NCT03275584_exc_T7", "arg2_id": "NCT03275584_exc_T13", "normalized": [] } ]

[ { "id": "NCT03275584_inc_text", "type": "inclusion", "text": [ "Adult patient being referred for clinically indicated positron emission tomography myocardial perfusion imaging at the Centre hospitalier de l'Université de Montréal\n" ], "offsets": [ [ 0, 166 ] ] } ]

[ { "id": "NCT03275584_inc_T1", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03275584_inc_T2", "type": "Qualifier", "text": [ "clinically indicated" ], "offsets": [ [ 33, 53 ] ], "normalized": [] }, { "id": "NCT03275584_inc_T3", "type": "Procedure", "text": [ "positron emission tomography myocardial perfusion imaging" ], "offsets": [ [ 54, 111 ] ], "normalized": [] }, { "id": "NCT03275584_inc_T4", "type": "Visit", "text": [ "Centre hospitalier de l'Université de Montréal" ], "offsets": [ [ 119, 165 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03275584_inc_R1", "type": "AND", "arg1_id": "NCT03275584_inc_T3", "arg2_id": "NCT03275584_inc_T4", "normalized": [] }, { "id": "NCT03275584_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03275584_inc_T3", "arg2_id": "NCT03275584_inc_T2", "normalized": [] } ]

[ { "id": "NCT03278548_exc_text", "type": "exclusion", "text": [ "NA\n" ], "offsets": [ [ 0, 3 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT03278548_inc_text", "type": "inclusion", "text": [ "Patients undergoing elective abdominal surgery with an expected blood loss of = 500 ml\nASA Physical Status II - III\nSigned written informed consent form\nBody weight = 140 kg\nSepsis\nBurns\nRenal impairment (AKIN stage = 1) or acute and/or chronic renal replacement therapy\nIntracranial or cerebral haemorrhage\nCritically ill patients (typically admitted to the intensive care unit)\nHyperhydration\nPulmonary oedema\nDehydration\nHyperkalaemia\nSevere hypernatraemia\nSevere hyperchloraemia\nSeverely impaired hepatic function\nCongestive heart failure\nSevere coagulopathy\nOrgan transplant patients\nMetabolic alkalosis\nSimultaneous participation in another interventional clinical trial (drugs or medical devices studies)\n" ], "offsets": [ [ 0, 712 ] ] } ]

[ { "id": "NCT03278548_inc_T1", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 20, 28 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T2", "type": "Procedure", "text": [ "abdominal surgery" ], "offsets": [ [ 29, 46 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T3", "type": "Measurement", "text": [ "expected blood loss" ], "offsets": [ [ 55, 74 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T4", "type": "Value", "text": [ "= 500 ml" ], "offsets": [ [ 78, 86 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T5", "type": "Measurement", "text": [ "ASA Physical Status" ], "offsets": [ [ 87, 106 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T6", "type": "Value", "text": [ "II - III" ], "offsets": [ [ 107, 115 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T8", "type": "Measurement", "text": [ "Body weight" ], "offsets": [ [ 153, 164 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T9", "type": "Value", "text": [ "= 140 kg" ], "offsets": [ [ 165, 173 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T10", "type": "Condition", "text": [ "Sepsis" ], "offsets": [ [ 174, 180 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T11", "type": "Condition", "text": [ "Burns" ], "offsets": [ [ 181, 186 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T12", "type": "Condition", "text": [ "Renal impairment" ], "offsets": [ [ 187, 203 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T13", "type": "Measurement", "text": [ "AKIN stage" ], "offsets": [ [ 205, 215 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T14", "type": "Value", "text": [ "= 1" ], "offsets": [ [ 216, 219 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T15", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 224, 229 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T16", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 237, 244 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T17", "type": "Procedure", "text": [ "renal replacement therapy" ], "offsets": [ [ 245, 270 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T18", "type": "Scope", "text": [ "acute and/or chronic" ], "offsets": [ [ 224, 244 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T19", "type": "Condition", "text": [ "cerebral haemorrhage" ], "offsets": [ [ 287, 307 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T20", "type": "Condition", "text": [ "anial or cer", "hage\nCritic" ], "offsets": [ [ 278, 290 ], [ 303, 314 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T21", "type": "Condition", "text": [ "Critically ill" ], "offsets": [ [ 308, 322 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T22", "type": "Visit", "text": [ "intensive care unit" ], "offsets": [ [ 359, 378 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T23", "type": "Mood", "text": [ "typically" ], "offsets": [ [ 333, 342 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T24", "type": "Procedure", "text": [ "admitted" ], "offsets": [ [ 343, 351 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T25", "type": "Condition", "text": [ "Hyperhydration" ], "offsets": [ [ 380, 394 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T26", "type": "Condition", "text": [ "Pulmonary oedema" ], "offsets": [ [ 395, 411 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T27", "type": "Condition", "text": [ "Dehydration" ], "offsets": [ [ 412, 423 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T28", "type": "Condition", "text": [ "Hyperkalaemia" ], "offsets": [ [ 424, 437 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T29", "type": "Condition", "text": [ "hypernatraemia" ], "offsets": [ [ 445, 459 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T30", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 460, 466 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T31", "type": "Condition", "text": [ "hyperchloraemia" ], "offsets": [ [ 467, 482 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T32", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 483, 489 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T33", "type": "Condition", "text": [ "impaired hepatic function" ], "offsets": [ [ 492, 517 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T34", "type": "Qualifier", "text": [ "Severely" ], "offsets": [ [ 483, 491 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T35", "type": "Condition", "text": [ "Congestive heart failure" ], "offsets": [ [ 518, 542 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T36", "type": "Condition", "text": [ "coagulopathy" ], "offsets": [ [ 550, 562 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T37", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 543, 549 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T38", "type": "Procedure", "text": [ "Organ transplant" ], "offsets": [ [ 563, 579 ] ], "normalized": [] }, { "id": "NCT03278548_inc_T39", "type": "Condition", "text": [ "Metabolic alkalosis" ], "offsets": [ [ 589, 608 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03278548_inc_R1", "type": "Has_value", "arg1_id": "NCT03278548_inc_T3", "arg2_id": "NCT03278548_inc_T4", "normalized": [] }, { "id": "NCT03278548_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03278548_inc_T2", "arg2_id": "NCT03278548_inc_T1", "normalized": [] }, { "id": "NCT03278548_inc_R3", "type": "AND", "arg1_id": "NCT03278548_inc_T2", "arg2_id": "NCT03278548_inc_T3", "normalized": [] }, { "id": "NCT03278548_inc_R4", "type": "Has_value", "arg1_id": "NCT03278548_inc_T5", "arg2_id": "NCT03278548_inc_T6", "normalized": [] }, { "id": "NCT03278548_inc_R5", "type": "Has_value", "arg1_id": "NCT03278548_inc_T8", "arg2_id": "NCT03278548_inc_T9", "normalized": [] }, { "id": "NCT03278548_inc_R6", "type": "Has_value", "arg1_id": "NCT03278548_inc_T13", "arg2_id": "NCT03278548_inc_T14", "normalized": [] }, { "id": "NCT03278548_inc_R7", "type": "Subsumes", "arg1_id": "NCT03278548_inc_T12", "arg2_id": "NCT03278548_inc_T13", "normalized": [] }, { "id": "NCT03278548_inc_R8", "type": "Has_scope", "arg1_id": "NCT03278548_inc_T17", "arg2_id": "NCT03278548_inc_T18", "normalized": [] }, { "id": "NCT03278548_inc_R10", "type": "Has_mood", "arg1_id": "NCT03278548_inc_T24", "arg2_id": "NCT03278548_inc_T23", "normalized": [] }, { "id": "NCT03278548_inc_R9", "type": "AND", "arg1_id": "NCT03278548_inc_T24", "arg2_id": "NCT03278548_inc_T22", "normalized": [] }, { "id": "NCT03278548_inc_R11", "type": "AND", "arg1_id": "NCT03278548_inc_T21", "arg2_id": "NCT03278548_inc_T24", "normalized": [] }, { "id": "NCT03278548_inc_R12", "type": "Has_qualifier", "arg1_id": "NCT03278548_inc_T29", "arg2_id": "NCT03278548_inc_T30", "normalized": [] }, { "id": "NCT03278548_inc_R13", "type": "Has_qualifier", "arg1_id": "NCT03278548_inc_T31", "arg2_id": "NCT03278548_inc_T32", "normalized": [] }, { "id": "NCT03278548_inc_R14", "type": "Has_qualifier", "arg1_id": "NCT03278548_inc_T33", "arg2_id": "NCT03278548_inc_T34", "normalized": [] }, { "id": "NCT03278548_inc_R15", "type": "Has_qualifier", "arg1_id": "NCT03278548_inc_T36", "arg2_id": "NCT03278548_inc_T37", "normalized": [] } ]

[ { "id": "NCT03280017_exc_text", "type": "exclusion", "text": [ "History of morphine allergy\nHistory of bupivacaine allergy\nContraindication for ketamine infusion\nContraindication for thoracic paravertebral block\nAnticipated postoperative positive pressure ventilation\nBody mass index more than 35\nAny known psychiatric disorder\n" ], "offsets": [ [ 0, 264 ] ] } ]

[ { "id": "NCT03280017_exc_T1", "type": "Drug", "text": [ "morphine" ], "offsets": [ [ 11, 19 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T2", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 20, 27 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T3", "type": "Observation", "text": [ "History" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T4", "type": "Drug", "text": [ "bupivacaine" ], "offsets": [ [ 39, 50 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T5", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 51, 58 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T6", "type": "Observation", "text": [ "History" ], "offsets": [ [ 28, 35 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T7", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 59, 75 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T8", "type": "Drug", "text": [ "ketamine" ], "offsets": [ [ 80, 88 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T9", "type": "Procedure", "text": [ "ketamine infusion" ], "offsets": [ [ 80, 97 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T10", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 98, 114 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T11", "type": "Qualifier", "text": [ "thoracic" ], "offsets": [ [ 119, 127 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T12", "type": "Procedure", "text": [ "paravertebral block" ], "offsets": [ [ 128, 147 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T13", "type": "Temporal", "text": [ "postoperative" ], "offsets": [ [ 160, 173 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T14", "type": "Procedure", "text": [ "positive pressure ventilation" ], "offsets": [ [ 174, 203 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T15", "type": "Mood", "text": [ "Anticipated" ], "offsets": [ [ 148, 159 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T16", "type": "Scope", "text": [ "postoperative positive pressure ventilation" ], "offsets": [ [ 160, 203 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T17", "type": "Measurement", "text": [ "Body mass index" ], "offsets": [ [ 204, 219 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T18", "type": "Value", "text": [ "more than 35" ], "offsets": [ [ 220, 232 ] ], "normalized": [] }, { "id": "NCT03280017_exc_T19", "type": "Condition", "text": [ "psychiatric disorder" ], "offsets": [ [ 243, 263 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03280017_exc_R1", "type": "AND", "arg1_id": "NCT03280017_exc_T2", "arg2_id": "NCT03280017_exc_T1", "normalized": [] }, { "id": "NCT03280017_exc_R2", "type": "AND", "arg1_id": "NCT03280017_exc_T5", "arg2_id": "NCT03280017_exc_T4", "normalized": [] }, { "id": "NCT03280017_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03280017_exc_T5", "arg2_id": "NCT03280017_exc_T6", "normalized": [] }, { "id": "NCT03280017_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03280017_exc_T2", "arg2_id": "NCT03280017_exc_T3", "normalized": [] }, { "id": "NCT03280017_exc_R6", "type": "AND", "arg1_id": "NCT03280017_exc_T7", "arg2_id": "NCT03280017_exc_T9", "normalized": [] }, { "id": "NCT03280017_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03280017_exc_T12", "arg2_id": "NCT03280017_exc_T11", "normalized": [] }, { "id": "NCT03280017_exc_R8", "type": "AND", "arg1_id": "NCT03280017_exc_T10", "arg2_id": "NCT03280017_exc_T12", "normalized": [] }, { "id": "NCT03280017_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03280017_exc_T14", "arg2_id": "NCT03280017_exc_T13", "normalized": [] }, { "id": "NCT03280017_exc_R10", "type": "Has_mood", "arg1_id": "NCT03280017_exc_T16", "arg2_id": "NCT03280017_exc_T15", "normalized": [] }, { "id": "NCT03280017_exc_R11", "type": "Has_value", "arg1_id": "NCT03280017_exc_T17", "arg2_id": "NCT03280017_exc_T18", "normalized": [] } ]

[ { "id": "NCT03280017_inc_text", "type": "inclusion", "text": [ "American Society of Anesthesiologist physical status 1-3\nScheduled for elective video-assisted thoracic surgery\nAble to operate a patient-controlled analgesia device (PCA)\n" ], "offsets": [ [ 0, 172 ] ] } ]

[ { "id": "NCT03280017_inc_T1", "type": "Measurement", "text": [ "American Society of Anesthesiologist physical status" ], "offsets": [ [ 0, 52 ] ], "normalized": [] }, { "id": "NCT03280017_inc_T2", "type": "Value", "text": [ "1-3" ], "offsets": [ [ 53, 56 ] ], "normalized": [] }, { "id": "NCT03280017_inc_T3", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 71, 79 ] ], "normalized": [] }, { "id": "NCT03280017_inc_T4", "type": "Mood", "text": [ "Scheduled for" ], "offsets": [ [ 57, 70 ] ], "normalized": [] }, { "id": "NCT03280017_inc_T5", "type": "Procedure", "text": [ "video-assisted thoracic surgery" ], "offsets": [ [ 80, 111 ] ], "normalized": [] }, { "id": "NCT03280017_inc_T6", "type": "Device", "text": [ "patient-controlled analgesia device" ], "offsets": [ [ 130, 165 ] ], "normalized": [] }, { "id": "NCT03280017_inc_T7", "type": "Device", "text": [ "PCA" ], "offsets": [ [ 167, 170 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03280017_inc_R1", "type": "Has_value", "arg1_id": "NCT03280017_inc_T1", "arg2_id": "NCT03280017_inc_T2", "normalized": [] }, { "id": "NCT03280017_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03280017_inc_T5", "arg2_id": "NCT03280017_inc_T3", "normalized": [] }, { "id": "NCT03280017_inc_R3", "type": "Has_mood", "arg1_id": "NCT03280017_inc_T5", "arg2_id": "NCT03280017_inc_T4", "normalized": [] }, { "id": "NCT03280017_inc_R4", "type": "Subsumes", "arg1_id": "NCT03280017_inc_T6", "arg2_id": "NCT03280017_inc_T7", "normalized": [] } ]

[ { "id": "NCT03282006_exc_text", "type": "exclusion", "text": [ "Bacterial infection origin from another organ (e.g. pneumonia)\nSevere sepsis with multiorgan failure\nPerinephritic abscess\nPyonephrosis requiring drainage\nAllergy to pivmecillinam\nE.coli isolate resistant to pivmecillinam\nPregnancy/breastfeeding\nSevere neutropenia\nProstatitis\nSevere kidney failure (eGFR<15 ml/min)\nUsing valproate\n" ], "offsets": [ [ 0, 332 ] ] } ]

[ { "id": "NCT03282006_exc_T1", "type": "Condition", "text": [ "Bacterial infection" ], "offsets": [ [ 0, 19 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T2", "type": "Qualifier", "text": [ "another organ" ], "offsets": [ [ 32, 45 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T3", "type": "Condition", "text": [ "pneumonia" ], "offsets": [ [ 52, 61 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T4", "type": "Condition", "text": [ "Severe sepsis" ], "offsets": [ [ 63, 76 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T5", "type": "Condition", "text": [ "multiorgan failure" ], "offsets": [ [ 82, 100 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T6", "type": "Condition", "text": [ "Perinephritic abscess" ], "offsets": [ [ 101, 122 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T7", "type": "Condition", "text": [ "Pyonephrosis" ], "offsets": [ [ 123, 135 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T8", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 136, 145 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T9", "type": "Procedure", "text": [ "drainage" ], "offsets": [ [ 146, 154 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T10", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 155, 162 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T11", "type": "Drug", "text": [ "pivmecillinam" ], "offsets": [ [ 166, 179 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T12", "type": "Drug", "text": [ "pivmecillinam" ], "offsets": [ [ 208, 221 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T13", "type": "Condition", "text": [ "E.coli isolate" ], "offsets": [ [ 180, 194 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T14", "type": "Qualifier", "text": [ "resistant to pivmecillinam" ], "offsets": [ [ 195, 221 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T15", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 222, 231 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T16", "type": "Observation", "text": [ "breastfeeding" ], "offsets": [ [ 232, 245 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T17", "type": "Condition", "text": [ "neutropenia" ], "offsets": [ [ 253, 264 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T18", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 246, 252 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T19", "type": "Condition", "text": [ "Prostatitis" ], "offsets": [ [ 265, 276 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T20", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 277, 283 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T21", "type": "Condition", "text": [ "kidney failure" ], "offsets": [ [ 284, 298 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T22", "type": "Measurement", "text": [ "eGFR" ], "offsets": [ [ 300, 304 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T23", "type": "Value", "text": [ "<15 ml/min" ], "offsets": [ [ 304, 314 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T24", "type": "Scope", "text": [ "eGFR<15 ml/min" ], "offsets": [ [ 300, 314 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T25", "type": "Scope", "text": [ "Severe kidney failure" ], "offsets": [ [ 277, 298 ] ], "normalized": [] }, { "id": "NCT03282006_exc_T26", "type": "Drug", "text": [ "valproate" ], "offsets": [ [ 322, 331 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03282006_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03282006_exc_T1", "arg2_id": "NCT03282006_exc_T2", "normalized": [] }, { "id": "NCT03282006_exc_R2", "type": "Subsumes", "arg1_id": "NCT03282006_exc_T1", "arg2_id": "NCT03282006_exc_T3", "normalized": [] }, { "id": "NCT03282006_exc_R3", "type": "Has_mood", "arg1_id": "NCT03282006_exc_T9", "arg2_id": "NCT03282006_exc_T8", "normalized": [] }, { "id": "NCT03282006_exc_R4", "type": "AND", "arg1_id": "NCT03282006_exc_T7", "arg2_id": "NCT03282006_exc_T9", "normalized": [] }, { "id": "NCT03282006_exc_R5", "type": "AND", "arg1_id": "NCT03282006_exc_T10", "arg2_id": "NCT03282006_exc_T11", "normalized": [] }, { "id": "NCT03282006_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03282006_exc_T13", "arg2_id": "NCT03282006_exc_T14", "normalized": [] }, { "id": "NCT03282006_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03282006_exc_T17", "arg2_id": "NCT03282006_exc_T18", "normalized": [] }, { "id": "NCT03282006_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03282006_exc_T21", "arg2_id": "NCT03282006_exc_T20", "normalized": [] }, { "id": "NCT03282006_exc_R10", "type": "Has_value", "arg1_id": "NCT03282006_exc_T22", "arg2_id": "NCT03282006_exc_T23", "normalized": [] }, { "id": "NCT03282006_exc_R11", "type": "Subsumes", "arg1_id": "NCT03282006_exc_T25", "arg2_id": "NCT03282006_exc_T24", "normalized": [] } ]

[ { "id": "NCT03282006_inc_text", "type": "inclusion", "text": [ "E.coli in blood culture\nAND identical isolate in urine sample (>= 1.000 CFU) OR relevant clinical signs of UTI\n" ], "offsets": [ [ 0, 111 ] ] } ]

[ { "id": "NCT03282006_inc_T1", "type": "Procedure", "text": [ "blood culture" ], "offsets": [ [ 10, 23 ] ], "normalized": [] }, { "id": "NCT03282006_inc_T2", "type": "Value", "text": [ "E.coli" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT03282006_inc_T3", "type": "Value", "text": [ "identical isolate" ], "offsets": [ [ 28, 45 ] ], "normalized": [] }, { "id": "NCT03282006_inc_T4", "type": "Procedure", "text": [ "urine sample" ], "offsets": [ [ 49, 61 ] ], "normalized": [] }, { "id": "NCT03282006_inc_T5", "type": "Measurement", "text": [ "CFU" ], "offsets": [ [ 72, 75 ] ], "normalized": [] }, { "id": "NCT03282006_inc_T6", "type": "Value", "text": [ ">= 1.000" ], "offsets": [ [ 63, 71 ] ], "normalized": [] }, { "id": "NCT03282006_inc_T7", "type": "Mood", "text": [ "clinical signs" ], "offsets": [ [ 89, 103 ] ], "normalized": [] }, { "id": "NCT03282006_inc_T8", "type": "Condition", "text": [ "UTI" ], "offsets": [ [ 107, 110 ] ], "normalized": [] }, { "id": "NCT03282006_inc_T9", "type": "Scope", "text": [ ">= 1.000 CFU" ], "offsets": [ [ 63, 75 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03282006_inc_R1", "type": "Has_value", "arg1_id": "NCT03282006_inc_T1", "arg2_id": "NCT03282006_inc_T2", "normalized": [] }, { "id": "NCT03282006_inc_R2", "type": "Has_value", "arg1_id": "NCT03282006_inc_T4", "arg2_id": "NCT03282006_inc_T3", "normalized": [] }, { "id": "NCT03282006_inc_R3", "type": "Has_value", "arg1_id": "NCT03282006_inc_T5", "arg2_id": "NCT03282006_inc_T6", "normalized": [] }, { "id": "NCT03282006_inc_R4", "type": "Has_mood", "arg1_id": "NCT03282006_inc_T8", "arg2_id": "NCT03282006_inc_T7", "normalized": [] }, { "id": "NCT03282006_inc_R5", "type": "Subsumes", "arg1_id": "NCT03282006_inc_T3", "arg2_id": "NCT03282006_inc_T9", "normalized": [] } ]

[ { "id": "NCT03288428_exc_text", "type": "exclusion", "text": [ "can't understand patient controlled analgesia device refuse trial\n" ], "offsets": [ [ 0, 66 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT03288428_inc_text", "type": "inclusion", "text": [ "elective Laparoscopic myomectomy patients 24hr post-operative patient controlled analgesia analgesia no mild or severe liver or renal disfunction\n" ], "offsets": [ [ 0, 146 ] ] } ]

[ { "id": "NCT03288428_inc_T1", "type": "Qualifier", "text": [ "Laparoscopic" ], "offsets": [ [ 9, 21 ] ], "normalized": [] }, { "id": "NCT03288428_inc_T2", "type": "Procedure", "text": [ "myomectomy" ], "offsets": [ [ 22, 32 ] ], "normalized": [] }, { "id": "NCT03288428_inc_T3", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03288428_inc_T8", "type": "Temporal", "text": [ "24hr post-operative" ], "offsets": [ [ 42, 61 ] ], "normalized": [] }, { "id": "NCT03288428_inc_T9", "type": "Procedure", "text": [ "patient controlled analgesia" ], "offsets": [ [ 62, 90 ] ], "normalized": [] }, { "id": "NCT03288428_inc_T11", "type": "Negation", "text": [ "no" ], "offsets": [ [ 101, 103 ] ], "normalized": [] }, { "id": "NCT03288428_inc_T12", "type": "Qualifier", "text": [ "mild" ], "offsets": [ [ 104, 108 ] ], "normalized": [] }, { "id": "NCT03288428_inc_T13", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 112, 118 ] ], "normalized": [] }, { "id": "NCT03288428_inc_T14", "type": "Condition", "text": [ "renal disfunction" ], "offsets": [ [ 128, 145 ] ], "normalized": [] }, { "id": "NCT03288428_inc_T15", "type": "Condition", "text": [ "liver", "disfunction" ], "offsets": [ [ 119, 124 ], [ 134, 145 ] ], "normalized": [] }, { "id": "NCT03288428_inc_T16", "type": "Scope", "text": [ "liver or renal disfunction" ], "offsets": [ [ 119, 145 ] ], "normalized": [] }, { "id": "NCT03288428_inc_T17", "type": "Scope", "text": [ "mild or severe" ], "offsets": [ [ 104, 118 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03288428_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03288428_inc_T2", "arg2_id": "NCT03288428_inc_T1", "normalized": [] }, { "id": "NCT03288428_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03288428_inc_T2", "arg2_id": "NCT03288428_inc_T3", "normalized": [] }, { "id": "NCT03288428_inc_R3", "type": "Has_scope", "arg1_id": "NCT03288428_inc_T16", "arg2_id": "NCT03288428_inc_T17", "normalized": [] }, { "id": "NCT03288428_inc_R4", "type": "Has_negation", "arg1_id": "NCT03288428_inc_T16", "arg2_id": "NCT03288428_inc_T11", "normalized": [] } ]

[ { "id": "NCT03296488_exc_text", "type": "exclusion", "text": [ "Body mass index less than 18 kg/m2 or greater than 30 kg/m2.\nHistory of previous open-laparotomy.\nSurgery with major complication, or need blood transfusion.\nHistory of hypersensitivity or adverse reaction to local anesthetics, opioid, or any ingredient of the medications administered in this study.\nSevere comorbidity.\nChronic preoperative opioid consumption.\nPregnant or breastfeeding.\nInability to use the PCA device.\n" ], "offsets": [ [ 0, 422 ] ] } ]

[ { "id": "NCT03296488_exc_T1", "type": "Measurement", "text": [ "Body mass index" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T2", "type": "Value", "text": [ "less than 18 kg/m2" ], "offsets": [ [ 16, 34 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T3", "type": "Value", "text": [ "greater than 30 kg/m2" ], "offsets": [ [ 38, 59 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T4", "type": "Scope", "text": [ "less than 18 kg/m2 or greater than 30 kg/m2" ], "offsets": [ [ 16, 59 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T5", "type": "Procedure", "text": [ "open-laparotomy" ], "offsets": [ [ 81, 96 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T6", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 72, 80 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T7", "type": "Observation", "text": [ "History" ], "offsets": [ [ 61, 68 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T8", "type": "Condition", "text": [ "major complication" ], "offsets": [ [ 111, 129 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T9", "type": "Procedure", "text": [ "Surgery" ], "offsets": [ [ 98, 105 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T10", "type": "Mood", "text": [ "need" ], "offsets": [ [ 134, 138 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T11", "type": "Condition", "text": [ "blood transfusion" ], "offsets": [ [ 139, 156 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T12", "type": "Scope", "text": [ "major complication, or need blood transfusion" ], "offsets": [ [ 111, 156 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T13", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 169, 185 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T14", "type": "Condition", "text": [ "adverse reaction" ], "offsets": [ [ 189, 205 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T15", "type": "Drug", "text": [ "local anesthetics" ], "offsets": [ [ 209, 226 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T16", "type": "Drug", "text": [ "opioid" ], "offsets": [ [ 228, 234 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T17", "type": "Drug", "text": [ "ingredient of the medications administered in this study" ], "offsets": [ [ 243, 299 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T18", "type": "Scope", "text": [ "local anesthetics, opioid, or any ingredient of the medications administered in this study" ], "offsets": [ [ 209, 299 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T19", "type": "Scope", "text": [ "hypersensitivity or adverse reaction" ], "offsets": [ [ 169, 205 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T20", "type": "Condition", "text": [ "comorbidity" ], "offsets": [ [ 308, 319 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T21", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 301, 307 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T22", "type": "Qualifier", "text": [ "Chronic" ], "offsets": [ [ 321, 328 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T23", "type": "Temporal", "text": [ "preoperative" ], "offsets": [ [ 329, 341 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T24", "type": "Drug", "text": [ "opioid" ], "offsets": [ [ 342, 348 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T25", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 362, 370 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T26", "type": "Observation", "text": [ "breastfeeding" ], "offsets": [ [ 374, 387 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T27", "type": "Condition", "text": [ "Inability" ], "offsets": [ [ 389, 398 ] ], "normalized": [] }, { "id": "NCT03296488_exc_T28", "type": "Procedure", "text": [ "use the PCA" ], "offsets": [ [ 402, 413 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03296488_exc_R1", "type": "Has_scope", "arg1_id": "NCT03296488_exc_T1", "arg2_id": "NCT03296488_exc_T4", "normalized": [] }, { "id": "NCT03296488_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03296488_exc_T5", "arg2_id": "NCT03296488_exc_T6", "normalized": [] }, { "id": "NCT03296488_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03296488_exc_T5", "arg2_id": "NCT03296488_exc_T7", "normalized": [] }, { "id": "NCT03296488_exc_R4", "type": "Has_mood", "arg1_id": "NCT03296488_exc_T11", "arg2_id": "NCT03296488_exc_T10", "normalized": [] }, { "id": "NCT03296488_exc_R5", "type": "Has_scope", "arg1_id": "NCT03296488_exc_T9", "arg2_id": "NCT03296488_exc_T12", "normalized": [] }, { "id": "NCT03296488_exc_R6", "type": "Has_scope", "arg1_id": "NCT03296488_exc_T19", "arg2_id": "NCT03296488_exc_T18", "normalized": [] }, { "id": "NCT03296488_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03296488_exc_T20", "arg2_id": "NCT03296488_exc_T21", "normalized": [] }, { "id": "NCT03296488_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03296488_exc_T24", "arg2_id": "NCT03296488_exc_T23", "normalized": [] }, { "id": "NCT03296488_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03296488_exc_T24", "arg2_id": "NCT03296488_exc_T22", "normalized": [] }, { "id": "NCT03296488_exc_R10", "type": "AND", "arg1_id": "NCT03296488_exc_T27", "arg2_id": "NCT03296488_exc_T28", "normalized": [] } ]

[ { "id": "NCT03296488_inc_text", "type": "inclusion", "text": [ "Male or female who is among 20 to 80 years of age at screening.\nScheduled to electively undergo open-laparotomy.\nAmerican Society of Anesthesiology Physical Class 1-3.\nAbility and willingness to provide informed consent\n" ], "offsets": [ [ 0, 220 ] ] } ]

[ { "id": "NCT03296488_inc_T1", "type": "Person", "text": [ "Male" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03296488_inc_T2", "type": "Person", "text": [ "female" ], "offsets": [ [ 8, 14 ] ], "normalized": [] }, { "id": "NCT03296488_inc_T3", "type": "Value", "text": [ "20 to 80 years" ], "offsets": [ [ 28, 42 ] ], "normalized": [] }, { "id": "NCT03296488_inc_T4", "type": "Person", "text": [ "age" ], "offsets": [ [ 46, 49 ] ], "normalized": [] }, { "id": "NCT03296488_inc_T5", "type": "Temporal", "text": [ "at screening" ], "offsets": [ [ 50, 62 ] ], "normalized": [] }, { "id": "NCT03296488_inc_T6", "type": "Mood", "text": [ "Scheduled" ], "offsets": [ [ 64, 73 ] ], "normalized": [] }, { "id": "NCT03296488_inc_T7", "type": "Procedure", "text": [ "open-laparotomy" ], "offsets": [ [ 96, 111 ] ], "normalized": [] }, { "id": "NCT03296488_inc_T8", "type": "Mood", "text": [ "electively" ], "offsets": [ [ 77, 87 ] ], "normalized": [] }, { "id": "NCT03296488_inc_T9", "type": "Measurement", "text": [ "American Society of Anesthesiology Physical Class" ], "offsets": [ [ 113, 162 ] ], "normalized": [] }, { "id": "NCT03296488_inc_T10", "type": "Value", "text": [ "1-3" ], "offsets": [ [ 163, 166 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03296488_inc_R1", "type": "Has_value", "arg1_id": "NCT03296488_inc_T4", "arg2_id": "NCT03296488_inc_T3", "normalized": [] }, { "id": "NCT03296488_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03296488_inc_T4", "arg2_id": "NCT03296488_inc_T5", "normalized": [] }, { "id": "NCT03296488_inc_R3", "type": "Has_mood", "arg1_id": "NCT03296488_inc_T7", "arg2_id": "NCT03296488_inc_T8", "normalized": [] }, { "id": "NCT03296488_inc_R4", "type": "Has_mood", "arg1_id": "NCT03296488_inc_T7", "arg2_id": "NCT03296488_inc_T6", "normalized": [] }, { "id": "NCT03296488_inc_R5", "type": "Has_value", "arg1_id": "NCT03296488_inc_T9", "arg2_id": "NCT03296488_inc_T10", "normalized": [] } ]

[ { "id": "NCT03297021_exc_text", "type": "exclusion", "text": [ "Patients with allergies or contraindications to study medications\n" ], "offsets": [ [ 0, 66 ] ] } ]

[ { "id": "NCT03297021_exc_T1", "type": "Condition", "text": [ "allergies" ], "offsets": [ [ 14, 23 ] ], "normalized": [] }, { "id": "NCT03297021_exc_T2", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 27, 44 ] ], "normalized": [] }, { "id": "NCT03297021_exc_T3", "type": "Drug", "text": [ "study medications" ], "offsets": [ [ 48, 65 ] ], "normalized": [] }, { "id": "NCT03297021_exc_T4", "type": "Scope", "text": [ "allergies or contraindications" ], "offsets": [ [ 14, 44 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03297021_exc_R1", "type": "AND", "arg1_id": "NCT03297021_exc_T4", "arg2_id": "NCT03297021_exc_T3", "normalized": [] } ]

[ { "id": "NCT03297021_inc_text", "type": "inclusion", "text": [ "ASA I, II, III presenting for ambulatory surgery to be performed under general anesthesia\n" ], "offsets": [ [ 0, 90 ] ] } ]

[ { "id": "NCT03297021_inc_T1", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03297021_inc_T2", "type": "Value", "text": [ "I" ], "offsets": [ [ 4, 5 ] ], "normalized": [] }, { "id": "NCT03297021_inc_T3", "type": "Value", "text": [ "II" ], "offsets": [ [ 7, 9 ] ], "normalized": [] }, { "id": "NCT03297021_inc_T4", "type": "Value", "text": [ "III" ], "offsets": [ [ 11, 14 ] ], "normalized": [] }, { "id": "NCT03297021_inc_T5", "type": "Scope", "text": [ "I, II, III" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "NCT03297021_inc_T6", "type": "Procedure", "text": [ "ambulatory surgery" ], "offsets": [ [ 30, 48 ] ], "normalized": [] }, { "id": "NCT03297021_inc_T7", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 71, 89 ] ], "normalized": [] }, { "id": "NCT03297021_inc_T8", "type": "Qualifier", "text": [ "under general anesthesia" ], "offsets": [ [ 65, 89 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03297021_inc_R1", "type": "Has_scope", "arg1_id": "NCT03297021_inc_T1", "arg2_id": "NCT03297021_inc_T5", "normalized": [] }, { "id": "NCT03297021_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03297021_inc_T6", "arg2_id": "NCT03297021_inc_T8", "normalized": [] } ]

[ { "id": "NCT03297125_exc_text", "type": "exclusion", "text": [ "Optune compliance < 75%; they would be excluded from the final analyses.\nHistory of craniectomy or significant skull defect (contraindication to Optune).\nActive implantable medical device (i.e. DBS, spinal cord stimulator, pacemaker, defibrillator, vagus nerve stimulator, programmable shunt).\nKarnofsky Performance Status (KPS) < 60.\n" ], "offsets": [ [ 0, 335 ] ] } ]

[ { "id": "NCT03297125_exc_T1", "type": "Observation", "text": [ "Optune compliance" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T2", "type": "Multiplier", "text": [ "< 75%" ], "offsets": [ [ 18, 23 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T4", "type": "Procedure", "text": [ "craniectomy" ], "offsets": [ [ 84, 95 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T5", "type": "Condition", "text": [ "skull defect" ], "offsets": [ [ 111, 123 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T6", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 99, 110 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T7", "type": "Device", "text": [ "Optune" ], "offsets": [ [ 145, 151 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T8", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 125, 141 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T9", "type": "Device", "text": [ "implantable medical device" ], "offsets": [ [ 161, 187 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T10", "type": "Device", "text": [ "DBS" ], "offsets": [ [ 194, 197 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T11", "type": "Device", "text": [ "spinal cord stimulator" ], "offsets": [ [ 199, 221 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T12", "type": "Device", "text": [ "pacemaker" ], "offsets": [ [ 223, 232 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T13", "type": "Device", "text": [ "defibrillator" ], "offsets": [ [ 234, 247 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T14", "type": "Device", "text": [ "vagus nerve stimulator" ], "offsets": [ [ 249, 271 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T15", "type": "Device", "text": [ "programmable shunt" ], "offsets": [ [ 273, 291 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T16", "type": "Scope", "text": [ "DBS, spinal cord stimulator, pacemaker, defibrillator, vagus nerve stimulator, programmable shunt" ], "offsets": [ [ 194, 291 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T17", "type": "Qualifier", "text": [ "Active" ], "offsets": [ [ 154, 160 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T18", "type": "Measurement", "text": [ "Karnofsky Performance Status" ], "offsets": [ [ 294, 322 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T19", "type": "Measurement", "text": [ "KPS" ], "offsets": [ [ 324, 327 ] ], "normalized": [] }, { "id": "NCT03297125_exc_T20", "type": "Value", "text": [ "< 60" ], "offsets": [ [ 329, 333 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03297125_exc_R1", "type": "Has_multiplier", "arg1_id": "NCT03297125_exc_T1", "arg2_id": "NCT03297125_exc_T2", "normalized": [] }, { "id": "NCT03297125_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03297125_exc_T5", "arg2_id": "NCT03297125_exc_T6", "normalized": [] }, { "id": "NCT03297125_exc_R3", "type": "AND", "arg1_id": "NCT03297125_exc_T8", "arg2_id": "NCT03297125_exc_T7", "normalized": [] }, { "id": "NCT03297125_exc_R4", "type": "Subsumes", "arg1_id": "NCT03297125_exc_T9", "arg2_id": "NCT03297125_exc_T16", "normalized": [] }, { "id": "NCT03297125_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03297125_exc_T9", "arg2_id": "NCT03297125_exc_T17", "normalized": [] }, { "id": "NCT03297125_exc_R6", "type": "Subsumes", "arg1_id": "NCT03297125_exc_T18", "arg2_id": "NCT03297125_exc_T19", "normalized": [] }, { "id": "NCT03297125_exc_R7", "type": "Has_value", "arg1_id": "NCT03297125_exc_T18", "arg2_id": "NCT03297125_exc_T20", "normalized": [] } ]

[ { "id": "NCT03297125_inc_text", "type": "inclusion", "text": [ "Newly diagnosed glioblastoma (GBM), WHO grade IV.\n" ], "offsets": [ [ 0, 50 ] ] } ]

[ { "id": "NCT03297125_inc_T1", "type": "Condition", "text": [ "glioblastoma" ], "offsets": [ [ 16, 28 ] ], "normalized": [] }, { "id": "NCT03297125_inc_T2", "type": "Condition", "text": [ "GBM" ], "offsets": [ [ 30, 33 ] ], "normalized": [] }, { "id": "NCT03297125_inc_T3", "type": "Measurement", "text": [ "WHO" ], "offsets": [ [ 36, 39 ] ], "normalized": [] }, { "id": "NCT03297125_inc_T4", "type": "Value", "text": [ "grade IV" ], "offsets": [ [ 40, 48 ] ], "normalized": [] }, { "id": "NCT03297125_inc_T5", "type": "Qualifier", "text": [ "Newly diagnosed" ], "offsets": [ [ 0, 15 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03297125_inc_R1", "type": "Has_value", "arg1_id": "NCT03297125_inc_T3", "arg2_id": "NCT03297125_inc_T4", "normalized": [] }, { "id": "NCT03297125_inc_R2", "type": "Subsumes", "arg1_id": "NCT03297125_inc_T1", "arg2_id": "NCT03297125_inc_T2", "normalized": [] }, { "id": "NCT03297125_inc_R3", "type": "AND", "arg1_id": "NCT03297125_inc_T1", "arg2_id": "NCT03297125_inc_T3", "normalized": [] }, { "id": "NCT03297125_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03297125_inc_T1", "arg2_id": "NCT03297125_inc_T5", "normalized": [] } ]

[ { "id": "NCT03297944_exc_text", "type": "exclusion", "text": [ "using daily medication for chronic condition\nacute narrow angle glaucoma\nprevious adverse experience with study drugs\nexperiences motion sickness in response to driving simulator\nBMI > 30\nwomen who are pregnant, lactating, or planning on becoming pregnant\nregular use of tobacco products\ncurrent substance use disorder\nclinically significant ECG\ncurrent ongoing psychiatric disorder\n" ], "offsets": [ [ 0, 383 ] ] } ]

[ { "id": "NCT03297944_exc_T1", "type": "Multiplier", "text": [ "daily" ], "offsets": [ [ 6, 11 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T2", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 12, 22 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T3", "type": "Condition", "text": [ "chronic condition" ], "offsets": [ [ 27, 44 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T4", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 45, 50 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T5", "type": "Condition", "text": [ "narrow angle glaucoma" ], "offsets": [ [ 51, 72 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T6", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 73, 81 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T7", "type": "Condition", "text": [ "adverse experience" ], "offsets": [ [ 82, 100 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T8", "type": "Drug", "text": [ "study drugs" ], "offsets": [ [ 106, 117 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T9", "type": "Condition", "text": [ "motion sickness" ], "offsets": [ [ 130, 145 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T10", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 179, 182 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T11", "type": "Value", "text": [ "> 30" ], "offsets": [ [ 183, 187 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T12", "type": "Person", "text": [ "women" ], "offsets": [ [ 188, 193 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T13", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 202, 210 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T14", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 212, 221 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T15", "type": "Mood", "text": [ "planning on becoming" ], "offsets": [ [ 226, 246 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T16", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 247, 255 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T17", "type": "Multiplier", "text": [ "regular" ], "offsets": [ [ 256, 263 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T18", "type": "Observation", "text": [ "use of tobacco products" ], "offsets": [ [ 264, 287 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T19", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 288, 295 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T20", "type": "Condition", "text": [ "substance use disorder" ], "offsets": [ [ 296, 318 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T21", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 319, 341 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T22", "type": "Procedure", "text": [ "ECG" ], "offsets": [ [ 342, 345 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T23", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 346, 353 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T24", "type": "Temporal", "text": [ "ongoing" ], "offsets": [ [ 354, 361 ] ], "normalized": [] }, { "id": "NCT03297944_exc_T25", "type": "Condition", "text": [ "psychiatric disorder" ], "offsets": [ [ 362, 382 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03297944_exc_R1", "type": "Has_multiplier", "arg1_id": "NCT03297944_exc_T2", "arg2_id": "NCT03297944_exc_T1", "normalized": [] }, { "id": "NCT03297944_exc_R2", "type": "AND", "arg1_id": "NCT03297944_exc_T2", "arg2_id": "NCT03297944_exc_T3", "normalized": [] }, { "id": "NCT03297944_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03297944_exc_T5", "arg2_id": "NCT03297944_exc_T4", "normalized": [] }, { "id": "NCT03297944_exc_R4", "type": "AND", "arg1_id": "NCT03297944_exc_T7", "arg2_id": "NCT03297944_exc_T8", "normalized": [] }, { "id": "NCT03297944_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03297944_exc_T7", "arg2_id": "NCT03297944_exc_T6", "normalized": [] }, { "id": "NCT03297944_exc_R6", "type": "Has_value", "arg1_id": "NCT03297944_exc_T10", "arg2_id": "NCT03297944_exc_T11", "normalized": [] }, { "id": "NCT03297944_exc_R7", "type": "Has_mood", "arg1_id": "NCT03297944_exc_T16", "arg2_id": "NCT03297944_exc_T15", "normalized": [] }, { "id": "NCT03297944_exc_R8", "type": "Has_multiplier", "arg1_id": "NCT03297944_exc_T18", "arg2_id": "NCT03297944_exc_T17", "normalized": [] }, { "id": "NCT03297944_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03297944_exc_T20", "arg2_id": "NCT03297944_exc_T19", "normalized": [] }, { "id": "NCT03297944_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03297944_exc_T22", "arg2_id": "NCT03297944_exc_T21", "normalized": [] }, { "id": "NCT03297944_exc_R11", "type": "Has_temporal", "arg1_id": "NCT03297944_exc_T25", "arg2_id": "NCT03297944_exc_T24", "normalized": [] }, { "id": "NCT03297944_exc_R12", "type": "Has_temporal", "arg1_id": "NCT03297944_exc_T25", "arg2_id": "NCT03297944_exc_T23", "normalized": [] } ]

[ { "id": "NCT03297944_inc_text", "type": "inclusion", "text": [ "valid driver's license\nenglish-speaking and literate\n" ], "offsets": [ [ 0, 53 ] ] } ]

[ { "id": "NCT03297944_inc_T1", "type": "Observation", "text": [ "valid driver's license" ], "offsets": [ [ 0, 22 ] ], "normalized": [] }, { "id": "NCT03297944_inc_T2", "type": "Observation", "text": [ "english-speaking" ], "offsets": [ [ 23, 39 ] ], "normalized": [] }, { "id": "NCT03297944_inc_T3", "type": "Observation", "text": [ "literate" ], "offsets": [ [ 44, 52 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT03299517_exc_text", "type": "exclusion", "text": [ "Pregnancy\nHemodynamic instability\nBody mass index greater than 40 kg / m2\nUse of intravenous amiodarone or lidocaine in the last 24 hours\nAcute coronary syndrome\nPresence of tachycardia with irregular or supraventricular RR\nContraindications to study drugs\n" ], "offsets": [ [ 0, 257 ] ] } ]

[ { "id": "NCT03299517_exc_T1", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T2", "type": "Condition", "text": [ "Hemodynamic instability" ], "offsets": [ [ 10, 33 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T3", "type": "Measurement", "text": [ "Body mass index" ], "offsets": [ [ 34, 49 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T4", "type": "Value", "text": [ "greater than 40 kg / m2" ], "offsets": [ [ 50, 73 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T5", "type": "Qualifier", "text": [ "intravenous" ], "offsets": [ [ 81, 92 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T6", "type": "Drug", "text": [ "amiodarone" ], "offsets": [ [ 93, 103 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T7", "type": "Drug", "text": [ "lidocaine" ], "offsets": [ [ 107, 116 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T8", "type": "Temporal", "text": [ "in the last 24 hours" ], "offsets": [ [ 117, 137 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T9", "type": "Scope", "text": [ "amiodarone or lidocaine" ], "offsets": [ [ 93, 116 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T10", "type": "Condition", "text": [ "Acute coronary syndrome" ], "offsets": [ [ 138, 161 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T11", "type": "Condition", "text": [ "tachycardia" ], "offsets": [ [ 174, 185 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T12", "type": "Condition", "text": [ "ular or s", "nt" ], "offsets": [ [ 196, 205 ], [ 226, 228 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T13", "type": "Condition", "text": [ "supraventricular RR" ], "offsets": [ [ 204, 223 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T14", "type": "Condition", "text": [ "Contraindications" ], "offsets": [ [ 224, 241 ] ], "normalized": [] }, { "id": "NCT03299517_exc_T15", "type": "Drug", "text": [ "study drugs" ], "offsets": [ [ 245, 256 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03299517_exc_R1", "type": "Has_value", "arg1_id": "NCT03299517_exc_T3", "arg2_id": "NCT03299517_exc_T4", "normalized": [] }, { "id": "NCT03299517_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03299517_exc_T9", "arg2_id": "NCT03299517_exc_T8", "normalized": [] }, { "id": "NCT03299517_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03299517_exc_T9", "arg2_id": "NCT03299517_exc_T5", "normalized": [] }, { "id": "NCT03299517_exc_R4", "type": "AND", "arg1_id": "NCT03299517_exc_T14", "arg2_id": "NCT03299517_exc_T15", "normalized": [] } ]

[ { "id": "NCT03299517_inc_text", "type": "inclusion", "text": [ "Adult men and women> 18 years old\nPresence of sustained ventricular tachycardia with HR> 120 bpm\nSystolic blood pressure> 90 mmHg\nNo signs of poor peripheral perfusion\nAbsence of dyspnea\nAbsence of severe angina\nSigned consent form\n" ], "offsets": [ [ 0, 232 ] ] } ]

[ { "id": "NCT03299517_inc_T1", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T2", "type": "Person", "text": [ "men" ], "offsets": [ [ 6, 9 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T3", "type": "Person", "text": [ "women" ], "offsets": [ [ 14, 19 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T4", "type": "Value", "text": [ "> 18 years old" ], "offsets": [ [ 19, 33 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T5", "type": "Person", "text": [ "old" ], "offsets": [ [ 30, 33 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T6", "type": "Qualifier", "text": [ "sustained" ], "offsets": [ [ 46, 55 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T7", "type": "Condition", "text": [ "ventricular tachycardia" ], "offsets": [ [ 56, 79 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T8", "type": "Measurement", "text": [ "HR" ], "offsets": [ [ 85, 87 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T9", "type": "Value", "text": [ "> 120 bpm" ], "offsets": [ [ 87, 96 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T10", "type": "Measurement", "text": [ "Systolic blood pressure" ], "offsets": [ [ 97, 120 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T11", "type": "Value", "text": [ "> 90 mmHg" ], "offsets": [ [ 120, 129 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T12", "type": "Negation", "text": [ "No" ], "offsets": [ [ 130, 132 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T13", "type": "Mood", "text": [ "signs of" ], "offsets": [ [ 133, 141 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T14", "type": "Condition", "text": [ "poor peripheral perfusion" ], "offsets": [ [ 142, 167 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T15", "type": "Condition", "text": [ "dyspnea" ], "offsets": [ [ 179, 186 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T16", "type": "Negation", "text": [ "Absence of" ], "offsets": [ [ 168, 178 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T17", "type": "Negation", "text": [ "Absence of" ], "offsets": [ [ 187, 197 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T18", "type": "Condition", "text": [ "angina" ], "offsets": [ [ 205, 211 ] ], "normalized": [] }, { "id": "NCT03299517_inc_T19", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 198, 204 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03299517_inc_R1", "type": "Has_value", "arg1_id": "NCT03299517_inc_T5", "arg2_id": "NCT03299517_inc_T4", "normalized": [] }, { "id": "NCT03299517_inc_R2", "type": "Has_value", "arg1_id": "NCT03299517_inc_T8", "arg2_id": "NCT03299517_inc_T9", "normalized": [] }, { "id": "NCT03299517_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03299517_inc_T7", "arg2_id": "NCT03299517_inc_T6", "normalized": [] }, { "id": "NCT03299517_inc_R4", "type": "AND", "arg1_id": "NCT03299517_inc_T7", "arg2_id": "NCT03299517_inc_T8", "normalized": [] }, { "id": "NCT03299517_inc_R5", "type": "Has_value", "arg1_id": "NCT03299517_inc_T10", "arg2_id": "NCT03299517_inc_T11", "normalized": [] }, { "id": "NCT03299517_inc_R6", "type": "Has_mood", "arg1_id": "NCT03299517_inc_T14", "arg2_id": "NCT03299517_inc_T13", "normalized": [] }, { "id": "NCT03299517_inc_R7", "type": "Has_negation", "arg1_id": "NCT03299517_inc_T14", "arg2_id": "NCT03299517_inc_T12", "normalized": [] }, { "id": "NCT03299517_inc_R8", "type": "Has_negation", "arg1_id": "NCT03299517_inc_T15", "arg2_id": "NCT03299517_inc_T16", "normalized": [] }, { "id": "NCT03299517_inc_R9", "type": "Has_qualifier", "arg1_id": "NCT03299517_inc_T18", "arg2_id": "NCT03299517_inc_T19", "normalized": [] }, { "id": "NCT03299517_inc_R10", "type": "Has_negation", "arg1_id": "NCT03299517_inc_T18", "arg2_id": "NCT03299517_inc_T17", "normalized": [] } ]

[ { "id": "NCT03304496_exc_text", "type": "exclusion", "text": [ "Pregnant.\nNot have informed consent for the present clinical trial, or do not fully understand the meaning of informed consent.\nWith acute myocardial infarction with ST segment elevation in the first 12 hours from the onset of symptoms.\nWith any acute coronary syndrome complicated with acute pulmonary edema, cardiogenic shock and / or malignant ventricular arrhythmias.\nIn which a cardiac catheterization is planned a priori to be performed via femoral, brachial or ulnar.\nPatients in whom first attempt of arterial puncture is performed by 2nd year interventional cardiology fellow or by physician in charge.\nParticipating in another clinical trial.\nBe allergic or have contraindications to nitroglycerin or other nitrates.\nAny phosphodiesterase 5 inhibitor (sildenafil, tadalafil, avanafil, vardenafil) has been taken within 72 hours prior to the study.\n" ], "offsets": [ [ 0, 858 ] ] } ]

[ { "id": "NCT03304496_exc_T1", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T3", "type": "Condition", "text": [ "acute myocardial infarction" ], "offsets": [ [ 133, 160 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T4", "type": "Condition", "text": [ "ST segment elevation" ], "offsets": [ [ 166, 186 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T5", "type": "Temporal", "text": [ "in the first 12 hours from the onset of symptoms" ], "offsets": [ [ 187, 235 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T6", "type": "Reference_point", "text": [ "the onset of symptoms" ], "offsets": [ [ 214, 235 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T7", "type": "Condition", "text": [ "acute coronary syndrome" ], "offsets": [ [ 246, 269 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T8", "type": "Condition", "text": [ "acute pulmonary edema" ], "offsets": [ [ 287, 308 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T9", "type": "Condition", "text": [ "cardiogenic shock" ], "offsets": [ [ 310, 327 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T10", "type": "Condition", "text": [ "ventricular arrhythmias" ], "offsets": [ [ 347, 370 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T11", "type": "Qualifier", "text": [ "malignant" ], "offsets": [ [ 337, 346 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T12", "type": "Scope", "text": [ "acute pulmonary edema, cardiogenic shock and / or malignant ventricular arrhythmias." ], "offsets": [ [ 287, 371 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T13", "type": "Procedure", "text": [ "cardiac catheterization" ], "offsets": [ [ 383, 406 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T14", "type": "Qualifier", "text": [ "femoral" ], "offsets": [ [ 447, 454 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T15", "type": "Qualifier", "text": [ "brachial" ], "offsets": [ [ 456, 464 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T16", "type": "Qualifier", "text": [ "ulnar" ], "offsets": [ [ 468, 473 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T17", "type": "Scope", "text": [ "femoral, brachial or ulnar" ], "offsets": [ [ 447, 473 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T20", "type": "Condition", "text": [ "allergic" ], "offsets": [ [ 656, 664 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T21", "type": "Drug", "text": [ "nitroglycerin" ], "offsets": [ [ 694, 707 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T22", "type": "Drug", "text": [ "nitrates" ], "offsets": [ [ 717, 725 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T23", "type": "Scope", "text": [ "nitroglycerin or other nitrates" ], "offsets": [ [ 694, 725 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T24", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 673, 690 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T25", "type": "Scope", "text": [ "allergic or have contraindications" ], "offsets": [ [ 656, 690 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T26", "type": "Drug", "text": [ "phosphodiesterase 5 inhibitor" ], "offsets": [ [ 731, 760 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T27", "type": "Drug", "text": [ "sildenafil" ], "offsets": [ [ 762, 772 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T28", "type": "Drug", "text": [ "tadalafil" ], "offsets": [ [ 774, 783 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T29", "type": "Drug", "text": [ "avanafil" ], "offsets": [ [ 785, 793 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T30", "type": "Drug", "text": [ "vardenafil" ], "offsets": [ [ 795, 805 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T31", "type": "Scope", "text": [ "sildenafil, tadalafil, avanafil, vardenafil)" ], "offsets": [ [ 762, 806 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T32", "type": "Temporal", "text": [ "within 72 hours prior to the study" ], "offsets": [ [ 822, 856 ] ], "normalized": [] }, { "id": "NCT03304496_exc_T33", "type": "Reference_point", "text": [ "study" ], "offsets": [ [ 851, 856 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03304496_exc_R1", "type": "Has_index", "arg1_id": "NCT03304496_exc_T5", "arg2_id": "NCT03304496_exc_T6", "normalized": [] }, { "id": "NCT03304496_exc_R2", "type": "AND", "arg1_id": "NCT03304496_exc_T3", "arg2_id": "NCT03304496_exc_T4", "normalized": [] }, { "id": "NCT03304496_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03304496_exc_T3", "arg2_id": "NCT03304496_exc_T5", "normalized": [] }, { "id": "NCT03304496_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03304496_exc_T10", "arg2_id": "NCT03304496_exc_T11", "normalized": [] }, { "id": "NCT03304496_exc_R5", "type": "Has_scope", "arg1_id": "NCT03304496_exc_T7", "arg2_id": "NCT03304496_exc_T12", "normalized": [] }, { "id": "NCT03304496_exc_R6", "type": "Has_scope", "arg1_id": "NCT03304496_exc_T13", "arg2_id": "NCT03304496_exc_T17", "normalized": [] }, { "id": "NCT03304496_exc_R7", "type": "Has_scope", "arg1_id": "NCT03304496_exc_T25", "arg2_id": "NCT03304496_exc_T23", "normalized": [] }, { "id": "NCT03304496_exc_R8", "type": "Subsumes", "arg1_id": "NCT03304496_exc_T26", "arg2_id": "NCT03304496_exc_T31", "normalized": [] }, { "id": "NCT03304496_exc_R9", "type": "Has_index", "arg1_id": "NCT03304496_exc_T32", "arg2_id": "NCT03304496_exc_T33", "normalized": [] }, { "id": "NCT03304496_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03304496_exc_T26", "arg2_id": "NCT03304496_exc_T32", "normalized": [] } ]

[ { "id": "NCT03304496_inc_text", "type": "inclusion", "text": [ "Men and women older than 18 years, scheduled consecutively to perform a coronary procedure in the department of hemodynamics of the National Institute of Cardiology \"Ignacio Chavez\".\nPatients may have any of the following indications for cardiac catheterization: Thoracic pain under study. Stable chronic coronary disease. Acute myocardial infarction with ST segment elevation, not perfused (without timely reperfusion therapy) with less than 4 weeks of evolution. Acute myocardial infarction with ST-segment elevation, successful thrombolytic therapy, which will undergo drug-invasive therapy. Acute myocardial infarction without ST segment elevation. Unstable angina. Any acute coronary syndrome, to intervene non-infarct-related artery. Disease of any heart valve. Myocarditis or pericarditis. Dilated cardiomyopathy. Patients in renal or cardiac transplantation protocol for any etiology. Congenital heart disease that requires knowing the coronary anatomy prior to surgical correction.\nThe planned procedure can be any of the following: For diagnostic purposes (coronary angiography only, left catheterization, left and right catheterization). For therapeutic purposes: percutaneous coronary intervention (PCI), with or without stent placement.\nA priori access must be right or left radial artery.\nRadial arterial pulse may be present or absent by palpation.\nModified Allen or Barbeau test should be positive (presence of collateral palmar flow).\n" ], "offsets": [ [ 0, 1452 ] ] } ]

[ { "id": "NCT03304496_inc_T1", "type": "Person", "text": [ "Men" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T2", "type": "Person", "text": [ "women" ], "offsets": [ [ 8, 13 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T3", "type": "Person", "text": [ "years" ], "offsets": [ [ 28, 33 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T4", "type": "Value", "text": [ "older than 18" ], "offsets": [ [ 14, 27 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T5", "type": "Mood", "text": [ "scheduled" ], "offsets": [ [ 35, 44 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T6", "type": "Procedure", "text": [ "coronary procedure" ], "offsets": [ [ 72, 90 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T7", "type": "Visit", "text": [ "the National Institute of Cardiology \"Ignacio Chavez\"" ], "offsets": [ [ 128, 181 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T8", "type": "Procedure", "text": [ "cardiac catheterization" ], "offsets": [ [ 238, 261 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T9", "type": "Condition", "text": [ "indications" ], "offsets": [ [ 222, 233 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T10", "type": "Visit", "text": [ "department of hemodynamics" ], "offsets": [ [ 98, 124 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T11", "type": "Condition", "text": [ "Thoracic pain" ], "offsets": [ [ 263, 276 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T12", "type": "Qualifier", "text": [ "Stable" ], "offsets": [ [ 290, 296 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T13", "type": "Condition", "text": [ "chronic coronary disease" ], "offsets": [ [ 297, 321 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T14", "type": "Condition", "text": [ "Acute myocardial infarction" ], "offsets": [ [ 323, 350 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T15", "type": "Condition", "text": [ "ST segment elevation" ], "offsets": [ [ 356, 376 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T16", "type": "Procedure", "text": [ "reperfusion therapy" ], "offsets": [ [ 407, 426 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T17", "type": "Qualifier", "text": [ "timely" ], "offsets": [ [ 400, 406 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T18", "type": "Negation", "text": [ "without" ], "offsets": [ [ 392, 399 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T19", "type": "Temporal", "text": [ "with less than 4 weeks of evolution" ], "offsets": [ [ 428, 463 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T20", "type": "Reference_point", "text": [ "evolution" ], "offsets": [ [ 454, 463 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T21", "type": "Condition", "text": [ "Acute myocardial infarction" ], "offsets": [ [ 465, 492 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T22", "type": "Condition", "text": [ "ST-segment elevation" ], "offsets": [ [ 498, 518 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T23", "type": "Procedure", "text": [ "thrombolytic therapy" ], "offsets": [ [ 531, 551 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T24", "type": "Qualifier", "text": [ "successful" ], "offsets": [ [ 520, 530 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T25", "type": "Mood", "text": [ "will undergo" ], "offsets": [ [ 559, 571 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T26", "type": "Procedure", "text": [ "drug-invasive therapy" ], "offsets": [ [ 572, 593 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T27", "type": "Condition", "text": [ "Acute myocardial infarction" ], "offsets": [ [ 595, 622 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T28", "type": "Negation", "text": [ "without" ], "offsets": [ [ 623, 630 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T29", "type": "Condition", "text": [ "ST segment elevation" ], "offsets": [ [ 631, 651 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T30", "type": "Condition", "text": [ "Unstable angina" ], "offsets": [ [ 653, 668 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T31", "type": "Condition", "text": [ "acute coronary syndrome" ], "offsets": [ [ 674, 697 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T32", "type": "Procedure", "text": [ "intervene" ], "offsets": [ [ 702, 711 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T33", "type": "Qualifier", "text": [ "artery" ], "offsets": [ [ 732, 738 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T34", "type": "Qualifier", "text": [ "non-infarct-related" ], "offsets": [ [ 712, 731 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T35", "type": "Condition", "text": [ "Disease" ], "offsets": [ [ 740, 747 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T36", "type": "Qualifier", "text": [ "heart valve" ], "offsets": [ [ 755, 766 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T37", "type": "Condition", "text": [ "Myocarditis" ], "offsets": [ [ 768, 779 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T38", "type": "Condition", "text": [ "pericarditis" ], "offsets": [ [ 783, 795 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T39", "type": "Condition", "text": [ "cardiomyopathy" ], "offsets": [ [ 805, 819 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T40", "type": "Qualifier", "text": [ "Dilated" ], "offsets": [ [ 797, 804 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T41", "type": "Condition", "text": [ "cardiac transplantation" ], "offsets": [ [ 842, 865 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T42", "type": "Condition", "text": [ "enal", "ransplantation" ], "offsets": [ [ 834, 838 ], [ 851, 865 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T43", "type": "Condition", "text": [ "Congenital heart disease" ], "offsets": [ [ 893, 917 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T44", "type": "Qualifier", "text": [ "knowing the coronary anatomy" ], "offsets": [ [ 932, 960 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T45", "type": "Temporal", "text": [ "prior to surgical correction." ], "offsets": [ [ 961, 990 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T46", "type": "Reference_point", "text": [ "surgical correction" ], "offsets": [ [ 970, 989 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T47", "type": "Procedure", "text": [ "procedure" ], "offsets": [ [ 1003, 1012 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T48", "type": "Qualifier", "text": [ "diagnostic" ], "offsets": [ [ 1046, 1056 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T49", "type": "Procedure", "text": [ "coronary angiography" ], "offsets": [ [ 1067, 1087 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T50", "type": "Qualifier", "text": [ "only" ], "offsets": [ [ 1088, 1092 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T51", "type": "Procedure", "text": [ "left catheterization" ], "offsets": [ [ 1094, 1114 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T52", "type": "Procedure", "text": [ "ft a", "theterization)." ], "offsets": [ [ 1118, 1122 ], [ 1133, 1148 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T53", "type": "Procedure", "text": [ "right catheterization" ], "offsets": [ [ 1125, 1146 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T54", "type": "Scope", "text": [ "left and right catheterization" ], "offsets": [ [ 1116, 1146 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T55", "type": "Procedure", "text": [ "coronary angiography" ], "offsets": [ [ 1067, 1087 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T56", "type": "Procedure", "text": [ "coronary angiography" ], "offsets": [ [ 1067, 1087 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T57", "type": "Scope", "text": [ "coronary angiography only, left catheterization, left and right catheterization" ], "offsets": [ [ 1067, 1146 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T58", "type": "Qualifier", "text": [ "therapeutic" ], "offsets": [ [ 1153, 1164 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T59", "type": "Scope", "text": [ "Thoracic pain under study. Stable chronic coronary disease. Acute myocardial infarction with ST segment elevation, not perfused (without timely reperfusion therapy) with less than 4 weeks of evolution. Acute myocardial infarction with ST-segment elevation, successful thrombolytic therapy, which will undergo drug-invasive therapy. Acute myocardial infarction without ST segment elevation. Unstable angina. Any acute coronary syndrome, to intervene non-infarct-related artery. Disease of any heart valve. Myocarditis or pericarditis. Dilated cardiomyopathy. Patients in renal or cardiac transplantation protocol for any etiology. Congenital heart disease that requires knowing the coronary anatomy prior to surgical correction" ], "offsets": [ [ 263, 989 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T60", "type": "Procedure", "text": [ "percutaneous coronary intervention" ], "offsets": [ [ 1175, 1209 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T61", "type": "Procedure", "text": [ "PCI" ], "offsets": [ [ 1211, 1214 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T62", "type": "Procedure", "text": [ "stent placement" ], "offsets": [ [ 1233, 1248 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T63", "type": "Scope", "text": [ "diagnostic purposes (coronary angiography only, left catheterization, left and right catheterization). For therapeutic purposes: percutaneous coronary intervention (PCI), with or without stent placement" ], "offsets": [ [ 1046, 1248 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T64", "type": "Procedure", "text": [ "access" ], "offsets": [ [ 1259, 1265 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T65", "type": "Qualifier", "text": [ "priori" ], "offsets": [ [ 1252, 1258 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T66", "type": "Qualifier", "text": [ "left radial artery" ], "offsets": [ [ 1283, 1301 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T67", "type": "Qualifier", "text": [ "ht or", "ial artery.\nR" ], "offsets": [ [ 1277, 1282 ], [ 1291, 1304 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T68", "type": "Scope", "text": [ "right or left radial artery" ], "offsets": [ [ 1274, 1301 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T69", "type": "Condition", "text": [ "pulse" ], "offsets": [ [ 1319, 1324 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T70", "type": "Qualifier", "text": [ "Radial arterial" ], "offsets": [ [ 1303, 1318 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T71", "type": "Measurement", "text": [ "palpation" ], "offsets": [ [ 1353, 1362 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T72", "type": "Value", "text": [ "absent" ], "offsets": [ [ 1343, 1349 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T73", "type": "Value", "text": [ "present" ], "offsets": [ [ 1332, 1339 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T74", "type": "Scope", "text": [ "present or absent" ], "offsets": [ [ 1332, 1349 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T75", "type": "Measurement", "text": [ "ied Allen or B", "shou" ], "offsets": [ [ 1369, 1383 ], [ 1395, 1399 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T76", "type": "Measurement", "text": [ "Barbeau test" ], "offsets": [ [ 1382, 1394 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T77", "type": "Value", "text": [ "positive" ], "offsets": [ [ 1405, 1413 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T78", "type": "Scope", "text": [ "Modified Allen or Barbeau test" ], "offsets": [ [ 1364, 1394 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T79", "type": "Condition", "text": [ "collateral palmar flow" ], "offsets": [ [ 1427, 1449 ] ], "normalized": [] }, { "id": "NCT03304496_inc_T80", "type": "Qualifier", "text": [ "presence" ], "offsets": [ [ 1415, 1423 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03304496_inc_R1", "type": "Has_value", "arg1_id": "NCT03304496_inc_T3", "arg2_id": "NCT03304496_inc_T4", "normalized": [] }, { "id": "NCT03304496_inc_R2", "type": "Has_mood", "arg1_id": "NCT03304496_inc_T6", "arg2_id": "NCT03304496_inc_T5", "normalized": [] }, { "id": "NCT03304496_inc_R3", "type": "AND", "arg1_id": "NCT03304496_inc_T6", "arg2_id": "NCT03304496_inc_T10", "normalized": [] }, { "id": "NCT03304496_inc_R4", "type": "AND", "arg1_id": "NCT03304496_inc_T9", "arg2_id": "NCT03304496_inc_T8", "normalized": [] }, { "id": "NCT03304496_inc_R5", "type": "AND", "arg1_id": "NCT03304496_inc_T10", "arg2_id": "NCT03304496_inc_T7", "normalized": [] }, { "id": "NCT03304496_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T13", "arg2_id": "NCT03304496_inc_T12", "normalized": [] }, { "id": "NCT03304496_inc_R7", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T16", "arg2_id": "NCT03304496_inc_T17", "normalized": [] }, { "id": "NCT03304496_inc_R8", "type": "Has_negation", "arg1_id": "NCT03304496_inc_T16", "arg2_id": "NCT03304496_inc_T18", "normalized": [] }, { "id": "NCT03304496_inc_R9", "type": "Has_index", "arg1_id": "NCT03304496_inc_T19", "arg2_id": "NCT03304496_inc_T20", "normalized": [] }, { "id": "NCT03304496_inc_R10", "type": "Has_temporal", "arg1_id": "NCT03304496_inc_T16", "arg2_id": "NCT03304496_inc_T19", "normalized": [] }, { "id": "NCT03304496_inc_R11", "type": "AND", "arg1_id": "NCT03304496_inc_T14", "arg2_id": "NCT03304496_inc_T15", "normalized": [] }, { "id": "NCT03304496_inc_R12", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T23", "arg2_id": "NCT03304496_inc_T24", "normalized": [] }, { "id": "NCT03304496_inc_R13", "type": "AND", "arg1_id": "NCT03304496_inc_T14", "arg2_id": "NCT03304496_inc_T16", "normalized": [] }, { "id": "NCT03304496_inc_R14", "type": "AND", "arg1_id": "NCT03304496_inc_T21", "arg2_id": "NCT03304496_inc_T22", "normalized": [] }, { "id": "NCT03304496_inc_R15", "type": "AND", "arg1_id": "NCT03304496_inc_T21", "arg2_id": "NCT03304496_inc_T23", "normalized": [] }, { "id": "NCT03304496_inc_R16", "type": "AND", "arg1_id": "NCT03304496_inc_T21", "arg2_id": "NCT03304496_inc_T26", "normalized": [] }, { "id": "NCT03304496_inc_R17", "type": "Has_mood", "arg1_id": "NCT03304496_inc_T26", "arg2_id": "NCT03304496_inc_T25", "normalized": [] }, { "id": "NCT03304496_inc_R18", "type": "AND", "arg1_id": "NCT03304496_inc_T27", "arg2_id": "NCT03304496_inc_T29", "normalized": [] }, { "id": "NCT03304496_inc_R19", "type": "Has_negation", "arg1_id": "NCT03304496_inc_T29", "arg2_id": "NCT03304496_inc_T28", "normalized": [] }, { "id": "NCT03304496_inc_R20", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T33", "arg2_id": "NCT03304496_inc_T34", "normalized": [] }, { "id": "NCT03304496_inc_R21", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T32", "arg2_id": "NCT03304496_inc_T33", "normalized": [] }, { "id": "NCT03304496_inc_R22", "type": "AND", "arg1_id": "NCT03304496_inc_T31", "arg2_id": "NCT03304496_inc_T32", "normalized": [] }, { "id": "NCT03304496_inc_R23", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T35", "arg2_id": "NCT03304496_inc_T36", "normalized": [] }, { "id": "NCT03304496_inc_R24", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T39", "arg2_id": "NCT03304496_inc_T40", "normalized": [] }, { "id": "NCT03304496_inc_R25", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T43", "arg2_id": "NCT03304496_inc_T44", "normalized": [] }, { "id": "NCT03304496_inc_R26", "type": "Has_temporal", "arg1_id": "NCT03304496_inc_T43", "arg2_id": "NCT03304496_inc_T45", "normalized": [] }, { "id": "NCT03304496_inc_R27", "type": "Has_index", "arg1_id": "NCT03304496_inc_T45", "arg2_id": "NCT03304496_inc_T46", "normalized": [] }, { "id": "NCT03304496_inc_R28", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T49", "arg2_id": "NCT03304496_inc_T50", "normalized": [] }, { "id": "NCT03304496_inc_R29", "type": "AND", "arg1_id": "NCT03304496_inc_T56", "arg2_id": "NCT03304496_inc_T51", "normalized": [] }, { "id": "NCT03304496_inc_R30", "type": "Has_scope", "arg1_id": "NCT03304496_inc_T55", "arg2_id": "NCT03304496_inc_T54", "normalized": [] }, { "id": "NCT03304496_inc_R31", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T57", "arg2_id": "NCT03304496_inc_T48", "normalized": [] }, { "id": "NCT03304496_inc_R32", "type": "Subsumes", "arg1_id": "NCT03304496_inc_T9", "arg2_id": "NCT03304496_inc_T59", "normalized": [] }, { "id": "NCT03304496_inc_R33", "type": "Subsumes", "arg1_id": "NCT03304496_inc_T60", "arg2_id": "NCT03304496_inc_T61", "normalized": [] }, { "id": "NCT03304496_inc_R34", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T60", "arg2_id": "NCT03304496_inc_T58", "normalized": [] }, { "id": "NCT03304496_inc_R35", "type": "AND", "arg1_id": "NCT03304496_inc_T60", "arg2_id": "NCT03304496_inc_T62", "normalized": [] }, { "id": "NCT03304496_inc_R36", "type": "Subsumes", "arg1_id": "NCT03304496_inc_T47", "arg2_id": "NCT03304496_inc_T63", "normalized": [] }, { "id": "NCT03304496_inc_R37", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T64", "arg2_id": "NCT03304496_inc_T65", "normalized": [] }, { "id": "NCT03304496_inc_R38", "type": "Has_scope", "arg1_id": "NCT03304496_inc_T64", "arg2_id": "NCT03304496_inc_T68", "normalized": [] }, { "id": "NCT03304496_inc_R39", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T69", "arg2_id": "NCT03304496_inc_T70", "normalized": [] }, { "id": "NCT03304496_inc_R40", "type": "Has_scope", "arg1_id": "NCT03304496_inc_T71", "arg2_id": "NCT03304496_inc_T74", "normalized": [] }, { "id": "NCT03304496_inc_R41", "type": "AND", "arg1_id": "NCT03304496_inc_T69", "arg2_id": "NCT03304496_inc_T71", "normalized": [] }, { "id": "NCT03304496_inc_R42", "type": "Has_value", "arg1_id": "NCT03304496_inc_T78", "arg2_id": "NCT03304496_inc_T77", "normalized": [] }, { "id": "NCT03304496_inc_R43", "type": "Has_qualifier", "arg1_id": "NCT03304496_inc_T79", "arg2_id": "NCT03304496_inc_T80", "normalized": [] } ]

[ { "id": "NCT03305575_exc_text", "type": "exclusion", "text": [ "Abdominal and complex cervical cerclage (e.g. bulging bag)\nContraindication to neuraxial anesthesia\nKnown hypersensitivity to chloroprocaine (a.k.a. Ester allergy), paraaminobenzoic acid (PABA) or bupivacaine (a.k.a. Amide allergy)\nPseudocholinesterase deficiency\nConcomitant use with ergot-type oxytocic drugs\n" ], "offsets": [ [ 0, 311 ] ] } ]

[ { "id": "NCT03305575_exc_T1", "type": "Procedure", "text": [ "cervical cerclage" ], "offsets": [ [ 22, 39 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T2", "type": "Qualifier", "text": [ "complex" ], "offsets": [ [ 14, 21 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T3", "type": "Qualifier", "text": [ "Abdominal" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T4", "type": "Scope", "text": [ "Abdominal and complex" ], "offsets": [ [ 0, 21 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T5", "type": "Qualifier", "text": [ "bulging bag" ], "offsets": [ [ 46, 57 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T6", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 59, 75 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T7", "type": "Procedure", "text": [ "neuraxial anesthesia" ], "offsets": [ [ 79, 99 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T8", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 106, 122 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T9", "type": "Drug", "text": [ "chloroprocaine" ], "offsets": [ [ 126, 140 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T11", "type": "Condition", "text": [ "Ester allergy" ], "offsets": [ [ 149, 162 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T12", "type": "Drug", "text": [ "paraaminobenzoic acid" ], "offsets": [ [ 165, 186 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T13", "type": "Drug", "text": [ "PABA" ], "offsets": [ [ 188, 192 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T14", "type": "Drug", "text": [ "bupivacaine" ], "offsets": [ [ 197, 208 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T15", "type": "Condition", "text": [ "Amide allergy" ], "offsets": [ [ 217, 230 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T10", "type": "Scope", "text": [ "loroprocaine (", "raaminobenzoic acid (PABA) or bupivacaine (" ], "offsets": [ [ 128, 142 ], [ 167, 210 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T16", "type": "Condition", "text": [ "Pseudocholinesterase deficiency" ], "offsets": [ [ 232, 263 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T17", "type": "Temporal", "text": [ "Concomitant" ], "offsets": [ [ 264, 275 ] ], "normalized": [] }, { "id": "NCT03305575_exc_T18", "type": "Drug", "text": [ "ergot-type oxytocic drugs" ], "offsets": [ [ 285, 310 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03305575_exc_R1", "type": "Has_scope", "arg1_id": "NCT03305575_exc_T1", "arg2_id": "NCT03305575_exc_T4", "normalized": [] }, { "id": "NCT03305575_exc_R2", "type": "Subsumes", "arg1_id": "NCT03305575_exc_T4", "arg2_id": "NCT03305575_exc_T5", "normalized": [] }, { "id": "NCT03305575_exc_R3", "type": "AND", "arg1_id": "NCT03305575_exc_T6", "arg2_id": "NCT03305575_exc_T7", "normalized": [] }, { "id": "NCT03305575_exc_R6", "type": "Subsumes", "arg1_id": "NCT03305575_exc_T12", "arg2_id": "NCT03305575_exc_T13", "normalized": [] }, { "id": "NCT03305575_exc_R4", "type": "Has_scope", "arg1_id": "NCT03305575_exc_T8", "arg2_id": "NCT03305575_exc_T10", "normalized": [] }, { "id": "NCT03305575_exc_R5", "type": "Subsumes", "arg1_id": "NCT03305575_exc_T8", "arg2_id": "NCT03305575_exc_T11", "normalized": [] }, { "id": "NCT03305575_exc_R7", "type": "Subsumes", "arg1_id": "NCT03305575_exc_T8", "arg2_id": "NCT03305575_exc_T15", "normalized": [] }, { "id": "NCT03305575_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03305575_exc_T18", "arg2_id": "NCT03305575_exc_T17", "normalized": [] } ]

[ { "id": "NCT03305575_inc_text", "type": "inclusion", "text": [ "ASA classification II or III females\nAge: 18-45 years old\nBMI = 50 kg/m2\nSingleton pregnancy\nSimple prophylactic cervical cerclage\nPlanning neuraxial anesthesia\n" ], "offsets": [ [ 0, 161 ] ] } ]

[ { "id": "NCT03305575_inc_T1", "type": "Measurement", "text": [ "ASA classification" ], "offsets": [ [ 0, 18 ] ], "normalized": [] }, { "id": "NCT03305575_inc_T2", "type": "Value", "text": [ "II or III" ], "offsets": [ [ 19, 28 ] ], "normalized": [] }, { "id": "NCT03305575_inc_T3", "type": "Person", "text": [ "females" ], "offsets": [ [ 29, 36 ] ], "normalized": [] }, { "id": "NCT03305575_inc_T4", "type": "Person", "text": [ "Age" ], "offsets": [ [ 37, 40 ] ], "normalized": [] }, { "id": "NCT03305575_inc_T5", "type": "Value", "text": [ "18-45 years old" ], "offsets": [ [ 42, 57 ] ], "normalized": [] }, { "id": "NCT03305575_inc_T6", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 58, 61 ] ], "normalized": [] }, { "id": "NCT03305575_inc_T7", "type": "Value", "text": [ "= 50 kg/m2" ], "offsets": [ [ 62, 72 ] ], "normalized": [] }, { "id": "NCT03305575_inc_T8", "type": "Condition", "text": [ "Singleton pregnancy" ], "offsets": [ [ 73, 92 ] ], "normalized": [] }, { "id": "NCT03305575_inc_T9", "type": "Qualifier", "text": [ "prophylactic" ], "offsets": [ [ 100, 112 ] ], "normalized": [] }, { "id": "NCT03305575_inc_T10", "type": "Qualifier", "text": [ "Simple" ], "offsets": [ [ 93, 99 ] ], "normalized": [] }, { "id": "NCT03305575_inc_T11", "type": "Procedure", "text": [ "cervical cerclage" ], "offsets": [ [ 113, 130 ] ], "normalized": [] }, { "id": "NCT03305575_inc_T12", "type": "Procedure", "text": [ "neuraxial anesthesia" ], "offsets": [ [ 140, 160 ] ], "normalized": [] }, { "id": "NCT03305575_inc_T13", "type": "Mood", "text": [ "Planning" ], "offsets": [ [ 131, 139 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03305575_inc_R1", "type": "Has_value", "arg1_id": "NCT03305575_inc_T1", "arg2_id": "NCT03305575_inc_T2", "normalized": [] }, { "id": "NCT03305575_inc_R2", "type": "Has_value", "arg1_id": "NCT03305575_inc_T4", "arg2_id": "NCT03305575_inc_T5", "normalized": [] }, { "id": "NCT03305575_inc_R3", "type": "Has_value", "arg1_id": "NCT03305575_inc_T6", "arg2_id": "NCT03305575_inc_T7", "normalized": [] }, { "id": "NCT03305575_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03305575_inc_T11", "arg2_id": "NCT03305575_inc_T9", "normalized": [] }, { "id": "NCT03305575_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03305575_inc_T11", "arg2_id": "NCT03305575_inc_T10", "normalized": [] }, { "id": "NCT03305575_inc_R6", "type": "Has_mood", "arg1_id": "NCT03305575_inc_T12", "arg2_id": "NCT03305575_inc_T13", "normalized": [] } ]

[ { "id": "NCT03305666_exc_text", "type": "exclusion", "text": [ "Allergy or hypersensitivity to bupivacaine\nPregnancy\nIncarceration\nAge < 18 years\nIndwelling continuous thoracic epidural analgesia\n" ], "offsets": [ [ 0, 132 ] ] } ]

[ { "id": "NCT03305666_exc_T1", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03305666_exc_T2", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 11, 27 ] ], "normalized": [] }, { "id": "NCT03305666_exc_T3", "type": "Drug", "text": [ "bupivacaine" ], "offsets": [ [ 31, 42 ] ], "normalized": [] }, { "id": "NCT03305666_exc_T4", "type": "Scope", "text": [ "Allergy or hypersensitivity" ], "offsets": [ [ 0, 27 ] ], "normalized": [] }, { "id": "NCT03305666_exc_T5", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 43, 52 ] ], "normalized": [] }, { "id": "NCT03305666_exc_T6", "type": "Person", "text": [ "Incarceration" ], "offsets": [ [ 53, 66 ] ], "normalized": [] }, { "id": "NCT03305666_exc_T7", "type": "Person", "text": [ "Age" ], "offsets": [ [ 67, 70 ] ], "normalized": [] }, { "id": "NCT03305666_exc_T8", "type": "Value", "text": [ "< 18 years" ], "offsets": [ [ 71, 81 ] ], "normalized": [] }, { "id": "NCT03305666_exc_T9", "type": "Procedure", "text": [ "thoracic epidural analgesia" ], "offsets": [ [ 104, 131 ] ], "normalized": [] }, { "id": "NCT03305666_exc_T10", "type": "Qualifier", "text": [ "continuous" ], "offsets": [ [ 93, 103 ] ], "normalized": [] }, { "id": "NCT03305666_exc_T11", "type": "Qualifier", "text": [ "Indwelling" ], "offsets": [ [ 82, 92 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03305666_exc_R1", "type": "AND", "arg1_id": "NCT03305666_exc_T4", "arg2_id": "NCT03305666_exc_T3", "normalized": [] }, { "id": "NCT03305666_exc_R2", "type": "Has_value", "arg1_id": "NCT03305666_exc_T7", "arg2_id": "NCT03305666_exc_T8", "normalized": [] }, { "id": "NCT03305666_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03305666_exc_T9", "arg2_id": "NCT03305666_exc_T10", "normalized": [] }, { "id": "NCT03305666_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03305666_exc_T9", "arg2_id": "NCT03305666_exc_T11", "normalized": [] } ]

[ { "id": "NCT03305666_inc_text", "type": "inclusion", "text": [ "Patients undergoing SSRF at Denver Health Medical Center\n" ], "offsets": [ [ 0, 57 ] ] } ]

[ { "id": "NCT03305666_inc_T1", "type": "Procedure", "text": [ "SSRF" ], "offsets": [ [ 20, 24 ] ], "normalized": [] }, { "id": "NCT03305666_inc_T2", "type": "Visit", "text": [ "Denver Health Medical Center" ], "offsets": [ [ 28, 56 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03305666_inc_R1", "type": "AND", "arg1_id": "NCT03305666_inc_T1", "arg2_id": "NCT03305666_inc_T2", "normalized": [] } ]

[ { "id": "NCT03315975_exc_text", "type": "exclusion", "text": [ "are allergic to influenza vaccination\nhave received influenza vaccination within the past 6 months\nrequire prednisone, methotrexate, or other immunosuppressing medications\nhave HIV infection\nhave a history of solid organ or bone marrow transplant\nrequire combination immunotherapy\nare on other studies requiring blood draws that might exceed 450 mL total during the period of the influenza vaccine study\n" ], "offsets": [ [ 0, 404 ] ] } ]

[ { "id": "NCT03315975_exc_T1", "type": "Drug", "text": [ "influenza vaccination" ], "offsets": [ [ 16, 37 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T2", "type": "Condition", "text": [ "allergic" ], "offsets": [ [ 4, 12 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T3", "type": "Drug", "text": [ "influenza vaccination" ], "offsets": [ [ 52, 73 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T4", "type": "Temporal", "text": [ "within the past 6 months" ], "offsets": [ [ 74, 98 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T5", "type": "Drug", "text": [ "prednisone" ], "offsets": [ [ 107, 117 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T6", "type": "Drug", "text": [ "methotrexate" ], "offsets": [ [ 119, 131 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T7", "type": "Drug", "text": [ "immunosuppressing medications" ], "offsets": [ [ 142, 171 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T8", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 136, 141 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T9", "type": "Condition", "text": [ "HIV infection" ], "offsets": [ [ 177, 190 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T10", "type": "Procedure", "text": [ "bone marrow transplant" ], "offsets": [ [ 224, 246 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T11", "type": "Procedure", "text": [ "d organ or", "splant\nreq" ], "offsets": [ [ 213, 223 ], [ 240, 250 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T12", "type": "Qualifier", "text": [ "history" ], "offsets": [ [ 198, 205 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T13", "type": "Scope", "text": [ "solid organ or bone marrow transplant" ], "offsets": [ [ 209, 246 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T14", "type": "Procedure", "text": [ "combination immunotherapy" ], "offsets": [ [ 255, 280 ] ], "normalized": [] }, { "id": "NCT03315975_exc_T15", "type": "Mood", "text": [ "require" ], "offsets": [ [ 247, 254 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03315975_exc_R1", "type": "AND", "arg1_id": "NCT03315975_exc_T2", "arg2_id": "NCT03315975_exc_T1", "normalized": [] }, { "id": "NCT03315975_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03315975_exc_T3", "arg2_id": "NCT03315975_exc_T4", "normalized": [] }, { "id": "NCT03315975_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03315975_exc_T7", "arg2_id": "NCT03315975_exc_T8", "normalized": [] }, { "id": "NCT03315975_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03315975_exc_T13", "arg2_id": "NCT03315975_exc_T12", "normalized": [] }, { "id": "NCT03315975_exc_R5", "type": "Has_mood", "arg1_id": "NCT03315975_exc_T14", "arg2_id": "NCT03315975_exc_T15", "normalized": [] } ]

[ { "id": "NCT03315975_inc_text", "type": "inclusion", "text": [ "adults capable of providing consent\nhave a diagnosis of locally advanced or metastatic melanoma\n" ], "offsets": [ [ 0, 96 ] ] } ]

[ { "id": "NCT03315975_inc_T1", "type": "Person", "text": [ "adults" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT03315975_inc_T3", "type": "Condition", "text": [ "melanoma" ], "offsets": [ [ 87, 95 ] ], "normalized": [] }, { "id": "NCT03315975_inc_T4", "type": "Qualifier", "text": [ "metastatic" ], "offsets": [ [ 76, 86 ] ], "normalized": [] }, { "id": "NCT03315975_inc_T5", "type": "Qualifier", "text": [ "locally advanced" ], "offsets": [ [ 56, 72 ] ], "normalized": [] }, { "id": "NCT03315975_inc_T6", "type": "Scope", "text": [ "locally advanced or metastatic" ], "offsets": [ [ 56, 86 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03315975_inc_R1", "type": "Has_scope", "arg1_id": "NCT03315975_inc_T3", "arg2_id": "NCT03315975_inc_T6", "normalized": [] } ]

[ { "id": "NCT03317197_exc_text", "type": "exclusion", "text": [ "Pregnant women and young children aged <18 years;\nPatients with underlying disease cases without the possibility of resuscitation (e.g., terminal cancer);\nPatients with do-not-resuscitate (DNR) status;\nDeath by excessive bleeding (e.g., abdominal main artery rupture);\nPatients who have experienced in-hospital CA;\nPatients previously treated with steroid, anti-cancer medicine, or immunosuppression treatment before CA;\nPatients already been registered with other studies; or\nPatients from whom informed consent cannot be obtained\n" ], "offsets": [ [ 0, 532 ] ] } ]

[ { "id": "NCT03317197_exc_T1", "type": "Person", "text": [ "women" ], "offsets": [ [ 9, 14 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T2", "type": "Person", "text": [ "young children" ], "offsets": [ [ 19, 33 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T3", "type": "Person", "text": [ "aged" ], "offsets": [ [ 34, 38 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T4", "type": "Value", "text": [ "<18 years" ], "offsets": [ [ 39, 48 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T5", "type": "Condition", "text": [ "terminal cancer" ], "offsets": [ [ 137, 152 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T6", "type": "Condition", "text": [ "underlying disease" ], "offsets": [ [ 64, 82 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T7", "type": "Qualifier", "text": [ "without the possibility of resuscitation" ], "offsets": [ [ 89, 129 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T8", "type": "Observation", "text": [ "do-not-resuscitate (DNR) status" ], "offsets": [ [ 169, 200 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T10", "type": "Condition", "text": [ "Death by excessive bleeding" ], "offsets": [ [ 202, 229 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T9", "type": "Condition", "text": [ "main artery rupture" ], "offsets": [ [ 247, 266 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T11", "type": "Qualifier", "text": [ "abdominal" ], "offsets": [ [ 237, 246 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T12", "type": "Scope", "text": [ "abdominal main artery rupture" ], "offsets": [ [ 237, 266 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T13", "type": "Condition", "text": [ "CA" ], "offsets": [ [ 311, 313 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T14", "type": "Visit", "text": [ "hospital" ], "offsets": [ [ 302, 310 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T15", "type": "Qualifier", "text": [ "in-hospital" ], "offsets": [ [ 299, 310 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T16", "type": "Drug", "text": [ "anti-cancer medicine" ], "offsets": [ [ 357, 377 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T17", "type": "Drug", "text": [ "steroid" ], "offsets": [ [ 348, 355 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T18", "type": "Procedure", "text": [ "immunosuppression treatment" ], "offsets": [ [ 382, 409 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T19", "type": "Temporal", "text": [ "before CA" ], "offsets": [ [ 410, 419 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T20", "type": "Condition", "text": [ "CA" ], "offsets": [ [ 417, 419 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T22", "type": "Temporal", "text": [ "previously" ], "offsets": [ [ 324, 334 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T23", "type": "Procedure", "text": [ "treated" ], "offsets": [ [ 335, 342 ] ], "normalized": [] }, { "id": "NCT03317197_exc_T24", "type": "Scope", "text": [ "steroid, anti-cancer medicine" ], "offsets": [ [ 348, 377 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03317197_exc_R1", "type": "Has_value", "arg1_id": "NCT03317197_exc_T3", "arg2_id": "NCT03317197_exc_T4", "normalized": [] }, { "id": "NCT03317197_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03317197_exc_T6", "arg2_id": "NCT03317197_exc_T7", "normalized": [] }, { "id": "NCT03317197_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03317197_exc_T9", "arg2_id": "NCT03317197_exc_T11", "normalized": [] }, { "id": "NCT03317197_exc_R4", "type": "Subsumes", "arg1_id": "NCT03317197_exc_T10", "arg2_id": "NCT03317197_exc_T12", "normalized": [] }, { "id": "NCT03317197_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03317197_exc_T13", "arg2_id": "NCT03317197_exc_T15", "normalized": [] }, { "id": "NCT03317197_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03317197_exc_T18", "arg2_id": "NCT03317197_exc_T19", "normalized": [] }, { "id": "NCT03317197_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03317197_exc_T23", "arg2_id": "NCT03317197_exc_T22", "normalized": [] }, { "id": "NCT03317197_exc_R8", "type": "Has_scope", "arg1_id": "NCT03317197_exc_T23", "arg2_id": "NCT03317197_exc_T24", "normalized": [] } ]

[ { "id": "NCT03317197_inc_text", "type": "inclusion", "text": [ "The group of patients who participated in the study included adults aged at least 19 years among the atraumatic CA outpatients who came to the ER and received CPR.\n" ], "offsets": [ [ 0, 164 ] ] } ]

[ { "id": "NCT03317197_inc_T1", "type": "Person", "text": [ "adults" ], "offsets": [ [ 61, 67 ] ], "normalized": [] }, { "id": "NCT03317197_inc_T2", "type": "Person", "text": [ "aged" ], "offsets": [ [ 68, 72 ] ], "normalized": [] }, { "id": "NCT03317197_inc_T3", "type": "Value", "text": [ "at least 19 years" ], "offsets": [ [ 73, 90 ] ], "normalized": [] }, { "id": "NCT03317197_inc_T4", "type": "Condition", "text": [ "atraumatic CA" ], "offsets": [ [ 101, 114 ] ], "normalized": [] }, { "id": "NCT03317197_inc_T5", "type": "Visit", "text": [ "outpatients" ], "offsets": [ [ 115, 126 ] ], "normalized": [] }, { "id": "NCT03317197_inc_T6", "type": "Visit", "text": [ "ER" ], "offsets": [ [ 143, 145 ] ], "normalized": [] }, { "id": "NCT03317197_inc_T7", "type": "Procedure", "text": [ "CPR" ], "offsets": [ [ 159, 162 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03317197_inc_R1", "type": "Has_value", "arg1_id": "NCT03317197_inc_T2", "arg2_id": "NCT03317197_inc_T3", "normalized": [] } ]

[ { "id": "NCT03318393_exc_text", "type": "exclusion", "text": [ "Patients with known or suspected heparin induced thrombocytopenia prior to consent\nPatients with hepatic failure defined as coagulopathy with elevated transaminases more than three times normal values\nPatients with plan to decannulate from ECMO within 48 hours\nKnown or suspected pregnant women\nPrevious enrollment in this study\nPrimary language spoken that is not English or Spanish\n" ], "offsets": [ [ 0, 384 ] ] } ]

[ { "id": "NCT03318393_exc_T1", "type": "Drug", "text": [ "heparin" ], "offsets": [ [ 33, 40 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T2", "type": "Condition", "text": [ "thrombocytopenia" ], "offsets": [ [ 49, 65 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T3", "type": "Temporal", "text": [ "prior to consent" ], "offsets": [ [ 66, 82 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T4", "type": "Reference_point", "text": [ "consent" ], "offsets": [ [ 75, 82 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T5", "type": "Qualifier", "text": [ "heparin induced" ], "offsets": [ [ 33, 48 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T6", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 23, 32 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T7", "type": "Mood", "text": [ "known" ], "offsets": [ [ 14, 19 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T8", "type": "Scope", "text": [ "known or suspected" ], "offsets": [ [ 14, 32 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T9", "type": "Condition", "text": [ "hepatic failure" ], "offsets": [ [ 97, 112 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T10", "type": "Condition", "text": [ "coagulopathy" ], "offsets": [ [ 124, 136 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T11", "type": "Measurement", "text": [ "transaminases" ], "offsets": [ [ 151, 164 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T12", "type": "Value", "text": [ "levated", "ore than three times normal values" ], "offsets": [ [ 143, 150 ], [ 166, 200 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T13", "type": "Temporal", "text": [ "within 48 hours" ], "offsets": [ [ 245, 260 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T14", "type": "Procedure", "text": [ "decannulate from ECMO" ], "offsets": [ [ 223, 244 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T15", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 280, 288 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T16", "type": "Person", "text": [ "women" ], "offsets": [ [ 289, 294 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T17", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 270, 279 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T18", "type": "Mood", "text": [ "Known" ], "offsets": [ [ 261, 266 ] ], "normalized": [] }, { "id": "NCT03318393_exc_T19", "type": "Scope", "text": [ "Known or suspected" ], "offsets": [ [ 261, 279 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03318393_exc_R1", "type": "Has_index", "arg1_id": "NCT03318393_exc_T3", "arg2_id": "NCT03318393_exc_T4", "normalized": [] }, { "id": "NCT03318393_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03318393_exc_T2", "arg2_id": "NCT03318393_exc_T3", "normalized": [] }, { "id": "NCT03318393_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03318393_exc_T2", "arg2_id": "NCT03318393_exc_T5", "normalized": [] }, { "id": "NCT03318393_exc_R5", "type": "Has_scope", "arg1_id": "NCT03318393_exc_T2", "arg2_id": "NCT03318393_exc_T8", "normalized": [] }, { "id": "NCT03318393_exc_R6", "type": "Has_value", "arg1_id": "NCT03318393_exc_T11", "arg2_id": "NCT03318393_exc_T12", "normalized": [] }, { "id": "NCT03318393_exc_R7", "type": "Subsumes", "arg1_id": "NCT03318393_exc_T9", "arg2_id": "NCT03318393_exc_T10", "normalized": [] }, { "id": "NCT03318393_exc_R8", "type": "AND", "arg1_id": "NCT03318393_exc_T10", "arg2_id": "NCT03318393_exc_T11", "normalized": [] }, { "id": "NCT03318393_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03318393_exc_T14", "arg2_id": "NCT03318393_exc_T13", "normalized": [] }, { "id": "NCT03318393_exc_R10", "type": "Has_scope", "arg1_id": "NCT03318393_exc_T15", "arg2_id": "NCT03318393_exc_T19", "normalized": [] } ]

[ { "id": "NCT03318393_inc_text", "type": "inclusion", "text": [ "Age 1 day to less than 18 years\nCared for in the pediatric intensive care unit or pediatric cardiac intensive care unit\nreceiving venovenous or venoarterial ECMO\n" ], "offsets": [ [ 0, 162 ] ] } ]

[ { "id": "NCT03318393_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03318393_inc_T2", "type": "Value", "text": [ "1 day to less than 18 years" ], "offsets": [ [ 4, 31 ] ], "normalized": [] }, { "id": "NCT03318393_inc_T3", "type": "Visit", "text": [ "pediatric intensive care unit" ], "offsets": [ [ 49, 78 ] ], "normalized": [] }, { "id": "NCT03318393_inc_T4", "type": "Visit", "text": [ "pediatric cardiac intensive care unit" ], "offsets": [ [ 82, 119 ] ], "normalized": [] }, { "id": "NCT03318393_inc_T5", "type": "Procedure", "text": [ "venoarterial ECMO" ], "offsets": [ [ 144, 161 ] ], "normalized": [] }, { "id": "NCT03318393_inc_T6", "type": "Procedure", "text": [ "novenous o", "MO" ], "offsets": [ [ 132, 142 ], [ 159, 161 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03318393_inc_R1", "type": "Has_value", "arg1_id": "NCT03318393_inc_T1", "arg2_id": "NCT03318393_inc_T2", "normalized": [] } ]

[ { "id": "NCT03318874_exc_text", "type": "exclusion", "text": [ "Glaucoma,\nOcular allergy\nAutoimmune disease\nContact lens-wear during study\nCurrent punctal plugging\nPregnant/lactating\nCandidate for topical anti-inflammatory\nCicatricial meibomian gland dysfunction\n" ], "offsets": [ [ 0, 199 ] ] } ]

[ { "id": "NCT03318874_exc_T1", "type": "Condition", "text": [ "Glaucoma" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03318874_exc_T2", "type": "Condition", "text": [ "Ocular allergy" ], "offsets": [ [ 10, 24 ] ], "normalized": [] }, { "id": "NCT03318874_exc_T3", "type": "Condition", "text": [ "Autoimmune disease" ], "offsets": [ [ 25, 43 ] ], "normalized": [] }, { "id": "NCT03318874_exc_T4", "type": "Observation", "text": [ "Contact lens-wear" ], "offsets": [ [ 44, 61 ] ], "normalized": [] }, { "id": "NCT03318874_exc_T5", "type": "Temporal", "text": [ "during study" ], "offsets": [ [ 62, 74 ] ], "normalized": [] }, { "id": "NCT03318874_exc_T6", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 75, 82 ] ], "normalized": [] }, { "id": "NCT03318874_exc_T7", "type": "Condition", "text": [ "punctal plugging" ], "offsets": [ [ 83, 99 ] ], "normalized": [] }, { "id": "NCT03318874_exc_T8", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 100, 108 ] ], "normalized": [] }, { "id": "NCT03318874_exc_T9", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 109, 118 ] ], "normalized": [] }, { "id": "NCT03318874_exc_T10", "type": "Mood", "text": [ "Candidate for" ], "offsets": [ [ 119, 132 ] ], "normalized": [] }, { "id": "NCT03318874_exc_T11", "type": "Drug", "text": [ "topical anti-inflammatory" ], "offsets": [ [ 133, 158 ] ], "normalized": [] }, { "id": "NCT03318874_exc_T12", "type": "Qualifier", "text": [ "Cicatricial" ], "offsets": [ [ 159, 170 ] ], "normalized": [] }, { "id": "NCT03318874_exc_T13", "type": "Condition", "text": [ "meibomian gland dysfunction" ], "offsets": [ [ 171, 198 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03318874_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03318874_exc_T4", "arg2_id": "NCT03318874_exc_T5", "normalized": [] }, { "id": "NCT03318874_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03318874_exc_T7", "arg2_id": "NCT03318874_exc_T6", "normalized": [] }, { "id": "NCT03318874_exc_R3", "type": "Has_mood", "arg1_id": "NCT03318874_exc_T11", "arg2_id": "NCT03318874_exc_T10", "normalized": [] }, { "id": "NCT03318874_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03318874_exc_T13", "arg2_id": "NCT03318874_exc_T12", "normalized": [] } ]

[ { "id": "NCT03318874_inc_text", "type": "inclusion", "text": [ "Meibomian Gland Dysfunction\nEligible for heat treatment\nOcular Surface Disease Index (OSDI) >12\nQuality or expressibility score =20 years old: >1 or >20 years old: =1\nNon-invasive tear film break-up time (NITBUT) <10 s in at least one eye\nSchirmer-1 test >5 mm after 5 min\n" ], "offsets": [ [ 0, 273 ] ] } ]

[ { "id": "NCT03318874_inc_T1", "type": "Condition", "text": [ "Meibomian Gland Dysfunction" ], "offsets": [ [ 0, 27 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T2", "type": "Mood", "text": [ "Eligible for" ], "offsets": [ [ 28, 40 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T3", "type": "Procedure", "text": [ "heat treatment" ], "offsets": [ [ 41, 55 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T4", "type": "Measurement", "text": [ "Ocular Surface Disease Index" ], "offsets": [ [ 56, 84 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T5", "type": "Measurement", "text": [ "OSDI" ], "offsets": [ [ 86, 90 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T6", "type": "Value", "text": [ ">12" ], "offsets": [ [ 92, 95 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T7", "type": "Measurement", "text": [ "re =2", "lity or" ], "offsets": [ [ 125, 130 ], [ 99, 106 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T8", "type": "Measurement", "text": [ "expressibility score" ], "offsets": [ [ 107, 127 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T10", "type": "Measurement", "text": [ "Non-invasive tear film break-up time (NITBUT)" ], "offsets": [ [ 167, 212 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T11", "type": "Value", "text": [ "<10 s" ], "offsets": [ [ 213, 218 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T13", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 222, 234 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T14", "type": "Qualifier", "text": [ "eye" ], "offsets": [ [ 235, 238 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T12", "type": "Measurement", "text": [ "Schirmer-1 test" ], "offsets": [ [ 239, 254 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T15", "type": "Value", "text": [ ">5 mm" ], "offsets": [ [ 255, 260 ] ], "normalized": [] }, { "id": "NCT03318874_inc_T16", "type": "Temporal", "text": [ "after 5 min" ], "offsets": [ [ 261, 272 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03318874_inc_R1", "type": "Has_mood", "arg1_id": "NCT03318874_inc_T3", "arg2_id": "NCT03318874_inc_T2", "normalized": [] }, { "id": "NCT03318874_inc_R2", "type": "Subsumes", "arg1_id": "NCT03318874_inc_T4", "arg2_id": "NCT03318874_inc_T5", "normalized": [] }, { "id": "NCT03318874_inc_R3", "type": "Has_value", "arg1_id": "NCT03318874_inc_T4", "arg2_id": "NCT03318874_inc_T6", "normalized": [] }, { "id": "NCT03318874_inc_R4", "type": "Has_value", "arg1_id": "NCT03318874_inc_T10", "arg2_id": "NCT03318874_inc_T11", "normalized": [] }, { "id": "NCT03318874_inc_R5", "type": "Has_multiplier", "arg1_id": "NCT03318874_inc_T14", "arg2_id": "NCT03318874_inc_T13", "normalized": [] }, { "id": "NCT03318874_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03318874_inc_T10", "arg2_id": "NCT03318874_inc_T14", "normalized": [] }, { "id": "NCT03318874_inc_R7", "type": "Has_value", "arg1_id": "NCT03318874_inc_T12", "arg2_id": "NCT03318874_inc_T15", "normalized": [] }, { "id": "NCT03318874_inc_R8", "type": "Has_temporal", "arg1_id": "NCT03318874_inc_T12", "arg2_id": "NCT03318874_inc_T16", "normalized": [] } ]

[ { "id": "NCT03320057_exc_text", "type": "exclusion", "text": [ "Not pregnant\nNot seeking medication abortion\nUnder the age of 15\nContraindications for medication abortion\n" ], "offsets": [ [ 0, 107 ] ] } ]

[ { "id": "NCT03320057_exc_T1", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 4, 12 ] ], "normalized": [] }, { "id": "NCT03320057_exc_T2", "type": "Procedure", "text": [ "medication abortion" ], "offsets": [ [ 25, 44 ] ], "normalized": [] }, { "id": "NCT03320057_exc_T3", "type": "Person", "text": [ "age" ], "offsets": [ [ 55, 58 ] ], "normalized": [] }, { "id": "NCT03320057_exc_T4", "type": "Value", "text": [ "der t", "\n" ], "offsets": [ [ 47, 52 ], [ 64, 65 ] ], "normalized": [] }, { "id": "NCT03320057_exc_T5", "type": "Condition", "text": [ "Contraindications" ], "offsets": [ [ 65, 82 ] ], "normalized": [] }, { "id": "NCT03320057_exc_T6", "type": "Procedure", "text": [ "medication abortion" ], "offsets": [ [ 87, 106 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03320057_exc_R1", "type": "Has_value", "arg1_id": "NCT03320057_exc_T3", "arg2_id": "NCT03320057_exc_T4", "normalized": [] }, { "id": "NCT03320057_exc_R2", "type": "AND", "arg1_id": "NCT03320057_exc_T5", "arg2_id": "NCT03320057_exc_T6", "normalized": [] } ]

[ { "id": "NCT03320057_inc_text", "type": "inclusion", "text": [ "Women seeking medication abortion through 70 days gestation\nEligible for Mifeprex(r) at a study clinical site\nEnglish or Spanish speaking\nWilling and able to participate in the study, including willing to go to the study pharmacy to obtain mifepristone\n" ], "offsets": [ [ 0, 253 ] ] } ]

[ { "id": "NCT03320057_inc_T1", "type": "Person", "text": [ "Women" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03320057_inc_T2", "type": "Procedure", "text": [ "medication abortion" ], "offsets": [ [ 14, 33 ] ], "normalized": [] }, { "id": "NCT03320057_inc_T3", "type": "Temporal", "text": [ "through 70 days gestation" ], "offsets": [ [ 34, 59 ] ], "normalized": [] }, { "id": "NCT03320057_inc_T4", "type": "Drug", "text": [ "Mifeprex(r)" ], "offsets": [ [ 73, 84 ] ], "normalized": [] }, { "id": "NCT03320057_inc_T5", "type": "Mood", "text": [ "Eligible for" ], "offsets": [ [ 60, 72 ] ], "normalized": [] }, { "id": "NCT03320057_inc_T6", "type": "Visit", "text": [ "study clinical site" ], "offsets": [ [ 90, 109 ] ], "normalized": [] }, { "id": "NCT03320057_inc_T7", "type": "Observation", "text": [ "glish o", "eaking\nW" ], "offsets": [ [ 112, 119 ], [ 131, 139 ] ], "normalized": [] }, { "id": "NCT03320057_inc_T8", "type": "Observation", "text": [ "Spanish speaking" ], "offsets": [ [ 121, 137 ] ], "normalized": [] }, { "id": "NCT03320057_inc_T9", "type": "Observation", "text": [ "Willing and able to participate in the study" ], "offsets": [ [ 138, 182 ] ], "normalized": [] }, { "id": "NCT03320057_inc_T10", "type": "Observation", "text": [ "willing to go to the study pharmacy" ], "offsets": [ [ 194, 229 ] ], "normalized": [] }, { "id": "NCT03320057_inc_T11", "type": "Drug", "text": [ "mifepristone" ], "offsets": [ [ 240, 252 ] ], "normalized": [] }, { "id": "NCT03320057_inc_T12", "type": "Mood", "text": [ "to obtain" ], "offsets": [ [ 230, 239 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03320057_inc_R1", "type": "Has_temporal", "arg1_id": "NCT03320057_inc_T2", "arg2_id": "NCT03320057_inc_T3", "normalized": [] }, { "id": "NCT03320057_inc_R2", "type": "Has_mood", "arg1_id": "NCT03320057_inc_T4", "arg2_id": "NCT03320057_inc_T5", "normalized": [] }, { "id": "NCT03320057_inc_R3", "type": "AND", "arg1_id": "NCT03320057_inc_T4", "arg2_id": "NCT03320057_inc_T6", "normalized": [] }, { "id": "NCT03320057_inc_R4", "type": "AND", "arg1_id": "NCT03320057_inc_T10", "arg2_id": "NCT03320057_inc_T11", "normalized": [] }, { "id": "NCT03320057_inc_R5", "type": "Has_mood", "arg1_id": "NCT03320057_inc_T11", "arg2_id": "NCT03320057_inc_T12", "normalized": [] } ]

[ { "id": "NCT03323047_exc_text", "type": "exclusion", "text": [ "Patients Level III or greater on the American Society of Anesthesiologists (ASA) physical status classification system (as determined by the anesthesiologist)\nPatients with chronic conditions that would limit our ability to develop the study according to objectives, such as neurodevelopmental conditions preventing patients from understanding the Oucher tool\nHepatic or renal disease\ncardiac disease\nactive infection\ndiabetes mellitus\nsickle cell disease\nknown coagulation disorders\npre- operative treatment with anti-emetics, steroids, or analgesics\nAcetaminophen allergy or already receiving acetaminophen within 24 h of surgery\nComplicating health factors precluding the use of opioids or acetaminophen\nany other factors which would interfere with pain assessment and management\nPatients weighing more than 30 kg that would exceed maximum dexamethasone dose\nPatients who live without a home telephone\npatient living without parental supervision.\n" ], "offsets": [ [ 0, 950 ] ] } ]

[ { "id": "NCT03323047_exc_T1", "type": "Measurement", "text": [ "American Society of Anesthesiologists (ASA) physical status" ], "offsets": [ [ 37, 96 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T2", "type": "Value", "text": [ "Level III or greater" ], "offsets": [ [ 9, 29 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T3", "type": "Condition", "text": [ "chronic conditions" ], "offsets": [ [ 173, 191 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T4", "type": "Condition", "text": [ "neurodevelopmental conditions" ], "offsets": [ [ 275, 304 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T5", "type": "Observation", "text": [ "understanding the Oucher tool" ], "offsets": [ [ 330, 359 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T6", "type": "Condition", "text": [ "preventing" ], "offsets": [ [ 305, 315 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T7", "type": "Observation", "text": [ "limit our ability to develop the study according to objectives" ], "offsets": [ [ 203, 265 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T8", "type": "Scope", "text": [ "neurodevelopmental conditions preventing patients from understanding the Oucher tool" ], "offsets": [ [ 275, 359 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T9", "type": "Condition", "text": [ "renal disease" ], "offsets": [ [ 371, 384 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T10", "type": "Condition", "text": [ "patic o", "sease\nc" ], "offsets": [ [ 362, 369 ], [ 379, 386 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T11", "type": "Condition", "text": [ "cardiac disease" ], "offsets": [ [ 385, 400 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T12", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 408, 417 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T13", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 401, 407 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T14", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 418, 435 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T15", "type": "Condition", "text": [ "sickle cell disease" ], "offsets": [ [ 436, 455 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T16", "type": "Condition", "text": [ "coagulation disorders" ], "offsets": [ [ 462, 483 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T17", "type": "Drug", "text": [ "analgesics" ], "offsets": [ [ 541, 551 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T18", "type": "Drug", "text": [ "steroids" ], "offsets": [ [ 528, 536 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T19", "type": "Drug", "text": [ "anti-emetics" ], "offsets": [ [ 514, 526 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T20", "type": "Temporal", "text": [ "pre- operative" ], "offsets": [ [ 484, 498 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T21", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 499, 508 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T22", "type": "Scope", "text": [ "anti-emetics, steroids, or analgesics" ], "offsets": [ [ 514, 551 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T23", "type": "Drug", "text": [ "Acetaminophen" ], "offsets": [ [ 552, 565 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T24", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 566, 573 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T25", "type": "Drug", "text": [ "acetaminophen" ], "offsets": [ [ 595, 608 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T26", "type": "Temporal", "text": [ "within 24 h of surgery" ], "offsets": [ [ 609, 631 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T27", "type": "Condition", "text": [ "precluding" ], "offsets": [ [ 660, 670 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T28", "type": "Drug", "text": [ "opioids" ], "offsets": [ [ 682, 689 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T29", "type": "Drug", "text": [ "acetaminophen" ], "offsets": [ [ 693, 706 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T30", "type": "Condition", "text": [ "Complicating health factors" ], "offsets": [ [ 632, 659 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T31", "type": "Scope", "text": [ "opioids or acetaminophen" ], "offsets": [ [ 682, 706 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T32", "type": "Condition", "text": [ "interfere" ], "offsets": [ [ 737, 746 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T33", "type": "Procedure", "text": [ "pain assessment" ], "offsets": [ [ 752, 767 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T34", "type": "Procedure", "text": [ "management" ], "offsets": [ [ 772, 782 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T35", "type": "Condition", "text": [ "other factors" ], "offsets": [ [ 711, 724 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T37", "type": "Scope", "text": [ "pain assessment and management" ], "offsets": [ [ 752, 782 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T38", "type": "Measurement", "text": [ "weighing" ], "offsets": [ [ 792, 800 ] ], "normalized": [] }, { "id": "NCT03323047_exc_T39", "type": "Value", "text": [ "more than 30 kg" ], "offsets": [ [ 801, 816 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03323047_exc_R1", "type": "Has_value", "arg1_id": "NCT03323047_exc_T1", "arg2_id": "NCT03323047_exc_T2", "normalized": [] }, { "id": "NCT03323047_exc_R3", "type": "AND", "arg1_id": "NCT03323047_exc_T4", "arg2_id": "NCT03323047_exc_T6", "normalized": [] }, { "id": "NCT03323047_exc_R5", "type": "Subsumes", "arg1_id": "NCT03323047_exc_T3", "arg2_id": "NCT03323047_exc_T8", "normalized": [] }, { "id": "NCT03323047_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03323047_exc_T12", "arg2_id": "NCT03323047_exc_T13", "normalized": [] }, { "id": "NCT03323047_exc_R7", "type": "Has_scope", "arg1_id": "NCT03323047_exc_T21", "arg2_id": "NCT03323047_exc_T22", "normalized": [] }, { "id": "NCT03323047_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03323047_exc_T21", "arg2_id": "NCT03323047_exc_T20", "normalized": [] }, { "id": "NCT03323047_exc_R9", "type": "AND", "arg1_id": "NCT03323047_exc_T24", "arg2_id": "NCT03323047_exc_T23", "normalized": [] }, { "id": "NCT03323047_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03323047_exc_T25", "arg2_id": "NCT03323047_exc_T26", "normalized": [] }, { "id": "NCT03323047_exc_R11", "type": "AND", "arg1_id": "NCT03323047_exc_T30", "arg2_id": "NCT03323047_exc_T27", "normalized": [] }, { "id": "NCT03323047_exc_R12", "type": "Has_scope", "arg1_id": "NCT03323047_exc_T27", "arg2_id": "NCT03323047_exc_T31", "normalized": [] }, { "id": "NCT03323047_exc_R13", "type": "AND", "arg1_id": "NCT03323047_exc_T35", "arg2_id": "NCT03323047_exc_T32", "normalized": [] }, { "id": "NCT03323047_exc_R15", "type": "Has_scope", "arg1_id": "NCT03323047_exc_T32", "arg2_id": "NCT03323047_exc_T37", "normalized": [] }, { "id": "NCT03323047_exc_R16", "type": "Has_value", "arg1_id": "NCT03323047_exc_T38", "arg2_id": "NCT03323047_exc_T39", "normalized": [] } ]

[ { "id": "NCT03323047_inc_text", "type": "inclusion", "text": [ "Healthy patients\naged 3-13 years\nLevel I or level II on the American Society of Anesthesiologists (ASA) physical status classification system (as determined by the anesthesiologist)\nobstructive sleep apnea or recurrent throat infections\nundergoing elective tonsillectomy with or without adenoidectomy\nParents who agree to complete documentation and follow up at 14 days post-operation.\n" ], "offsets": [ [ 0, 386 ] ] } ]

[ { "id": "NCT03323047_inc_T1", "type": "Condition", "text": [ "Healthy" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03323047_inc_T2", "type": "Person", "text": [ "aged" ], "offsets": [ [ 17, 21 ] ], "normalized": [] }, { "id": "NCT03323047_inc_T3", "type": "Value", "text": [ "3-13 years" ], "offsets": [ [ 22, 32 ] ], "normalized": [] }, { "id": "NCT03323047_inc_T4", "type": "Measurement", "text": [ "American Society of Anesthesiologists (ASA) physical status" ], "offsets": [ [ 60, 119 ] ], "normalized": [] }, { "id": "NCT03323047_inc_T5", "type": "Value", "text": [ "Level I or level II" ], "offsets": [ [ 33, 52 ] ], "normalized": [] }, { "id": "NCT03323047_inc_T6", "type": "Condition", "text": [ "obstructive sleep apnea" ], "offsets": [ [ 182, 205 ] ], "normalized": [] }, { "id": "NCT03323047_inc_T7", "type": "Multiplier", "text": [ "recurrent" ], "offsets": [ [ 209, 218 ] ], "normalized": [] }, { "id": "NCT03323047_inc_T8", "type": "Condition", "text": [ "throat infections" ], "offsets": [ [ 219, 236 ] ], "normalized": [] }, { "id": "NCT03323047_inc_T9", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 248, 256 ] ], "normalized": [] }, { "id": "NCT03323047_inc_T10", "type": "Condition", "text": [ "tonsillectomy" ], "offsets": [ [ 257, 270 ] ], "normalized": [] }, { "id": "NCT03323047_inc_T11", "type": "Condition", "text": [ "adenoidectomy" ], "offsets": [ [ 287, 300 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03323047_inc_R1", "type": "Has_value", "arg1_id": "NCT03323047_inc_T2", "arg2_id": "NCT03323047_inc_T3", "normalized": [] }, { "id": "NCT03323047_inc_R2", "type": "Has_value", "arg1_id": "NCT03323047_inc_T4", "arg2_id": "NCT03323047_inc_T5", "normalized": [] }, { "id": "NCT03323047_inc_R3", "type": "Has_multiplier", "arg1_id": "NCT03323047_inc_T8", "arg2_id": "NCT03323047_inc_T7", "normalized": [] }, { "id": "NCT03323047_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03323047_inc_T10", "arg2_id": "NCT03323047_inc_T9", "normalized": [] }, { "id": "NCT03323047_inc_R5", "type": "AND", "arg1_id": "NCT03323047_inc_T10", "arg2_id": "NCT03323047_inc_T11", "normalized": [] } ]

[ { "id": "NCT03325023_exc_text", "type": "exclusion", "text": [ "Ovarian cancer, adrenal gland tumor, endometrial cancer, cervical cancer, breast cancer\nCongenital adrenal hyperplasia (17-OH-progesterone> 2.5 ng / mL)\nClinically diagnosed Cushing's disease, acromegaly, gigantism\nType I or II diabetes\nUnexplained bleeding from the genital tract\nHormone treatment within the last 2 months\n" ], "offsets": [ [ 0, 324 ] ] } ]

[ { "id": "NCT03325023_exc_T1", "type": "Condition", "text": [ "Ovarian cancer" ], "offsets": [ [ 0, 14 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T2", "type": "Condition", "text": [ "adrenal gland tumor" ], "offsets": [ [ 16, 35 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T3", "type": "Condition", "text": [ "endometrial cancer" ], "offsets": [ [ 37, 55 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T4", "type": "Condition", "text": [ "cervical cancer" ], "offsets": [ [ 57, 72 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T5", "type": "Condition", "text": [ "breast cancer" ], "offsets": [ [ 74, 87 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T6", "type": "Condition", "text": [ "Congenital adrenal hyperplasia" ], "offsets": [ [ 88, 118 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T7", "type": "Measurement", "text": [ "17-OH-progesterone" ], "offsets": [ [ 120, 138 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T8", "type": "Value", "text": [ "> 2.5 ng / mL" ], "offsets": [ [ 138, 151 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T9", "type": "Scope", "text": [ "17-OH-progesterone> 2.5 ng / mL" ], "offsets": [ [ 120, 151 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T10", "type": "Qualifier", "text": [ "Clinically diagnosed" ], "offsets": [ [ 153, 173 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T11", "type": "Condition", "text": [ "Cushing's disease" ], "offsets": [ [ 174, 191 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T12", "type": "Condition", "text": [ "acromegaly" ], "offsets": [ [ 193, 203 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T13", "type": "Condition", "text": [ "gigantism" ], "offsets": [ [ 205, 214 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T14", "type": "Scope", "text": [ "Cushing's disease, acromegaly, gigantism" ], "offsets": [ [ 174, 214 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T15", "type": "Condition", "text": [ "e I or", "betes\nUn" ], "offsets": [ [ 218, 224 ], [ 231, 239 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T16", "type": "Condition", "text": [ "e I", "diabetes\nUn" ], "offsets": [ [ 218, 221 ], [ 228, 239 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T17", "type": "Condition", "text": [ "Unexplained bleeding" ], "offsets": [ [ 237, 257 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T18", "type": "Qualifier", "text": [ "genital tract" ], "offsets": [ [ 267, 280 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T19", "type": "Procedure", "text": [ "Hormone treatment" ], "offsets": [ [ 281, 298 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T20", "type": "Drug", "text": [ "Hormone" ], "offsets": [ [ 281, 288 ] ], "normalized": [] }, { "id": "NCT03325023_exc_T21", "type": "Temporal", "text": [ "within the last 2 months" ], "offsets": [ [ 299, 323 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03325023_exc_R1", "type": "Has_value", "arg1_id": "NCT03325023_exc_T7", "arg2_id": "NCT03325023_exc_T8", "normalized": [] }, { "id": "NCT03325023_exc_R2", "type": "Subsumes", "arg1_id": "NCT03325023_exc_T6", "arg2_id": "NCT03325023_exc_T9", "normalized": [] }, { "id": "NCT03325023_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03325023_exc_T14", "arg2_id": "NCT03325023_exc_T10", "normalized": [] }, { "id": "NCT03325023_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03325023_exc_T17", "arg2_id": "NCT03325023_exc_T18", "normalized": [] }, { "id": "NCT03325023_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03325023_exc_T19", "arg2_id": "NCT03325023_exc_T21", "normalized": [] } ]

[ { "id": "NCT03325023_inc_text", "type": "inclusion", "text": [ "Written consent for participation in the clinical trial\nAge 18 to 45 years Irregular menstruation (> 35 days) or secondary amenorrhea> 3 months\n" ], "offsets": [ [ 0, 144 ] ] } ]

[ { "id": "NCT03325023_inc_T2", "type": "Person", "text": [ "Age" ], "offsets": [ [ 56, 59 ] ], "normalized": [] }, { "id": "NCT03325023_inc_T3", "type": "Value", "text": [ "18 to 45 years" ], "offsets": [ [ 60, 74 ] ], "normalized": [] }, { "id": "NCT03325023_inc_T4", "type": "Condition", "text": [ "Irregular menstruation" ], "offsets": [ [ 75, 97 ] ], "normalized": [] }, { "id": "NCT03325023_inc_T7", "type": "Value", "text": [ "> 35 days" ], "offsets": [ [ 99, 108 ] ], "normalized": [] }, { "id": "NCT03325023_inc_T8", "type": "Condition", "text": [ "secondary amenorrhea" ], "offsets": [ [ 113, 133 ] ], "normalized": [] }, { "id": "NCT03325023_inc_T9", "type": "Temporal", "text": [ "> 3 months" ], "offsets": [ [ 133, 143 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03325023_inc_R1", "type": "Subsumes", "arg1_id": "NCT03325023_inc_T4", "arg2_id": "NCT03325023_inc_T7", "normalized": [] }, { "id": "NCT03325023_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03325023_inc_T8", "arg2_id": "NCT03325023_inc_T9", "normalized": [] } ]

[ { "id": "NCT03328052_exc_text", "type": "exclusion", "text": [ "Diagnosis of a psychotic disorder.\nHistory of, or current, open head brain trauma. Candidates with any metal, shrapnel or other similar objects in the head that could affect the QEEG\nHistory of: craniotomy, cerebral metastases, cerebrovascular accident; current diagnosis of seizure disorder, schizophrenia, schizo-affective disorder, dementia, mental retardation, or major depression with psychotic features; or use of depot neuroleptics in last 12 months.\nUncontrolled thyroid disorders.\nKnown pregnancy and/or lactation, or intent to become pregnant during this study.\nChronic or acute pain requiring prescription pain medication(s) (narcotic or synthetic narcotic)\nParticipation in any other therapeutic drug study within 60 days preceding inclusion.\n" ], "offsets": [ [ 0, 755 ] ] } ]

[ { "id": "NCT03328052_exc_T1", "type": "Condition", "text": [ "psychotic disorder" ], "offsets": [ [ 15, 33 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T2", "type": "Condition", "text": [ "open head brain trauma" ], "offsets": [ [ 59, 81 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T3", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 50, 57 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T4", "type": "Observation", "text": [ "History" ], "offsets": [ [ 35, 42 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T5", "type": "Scope", "text": [ "History of, or current" ], "offsets": [ [ 35, 57 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T6", "type": "Device", "text": [ "metal" ], "offsets": [ [ 103, 108 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T7", "type": "Device", "text": [ "shrapnel" ], "offsets": [ [ 110, 118 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T8", "type": "Device", "text": [ "objects in the head" ], "offsets": [ [ 136, 155 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T9", "type": "Procedure", "text": [ "QEEG" ], "offsets": [ [ 178, 182 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T10", "type": "Condition", "text": [ "affect" ], "offsets": [ [ 167, 173 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T11", "type": "Scope", "text": [ "metal, shrapnel or other similar objects in the head" ], "offsets": [ [ 103, 155 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T12", "type": "Procedure", "text": [ "craniotomy" ], "offsets": [ [ 195, 205 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T13", "type": "Condition", "text": [ "cerebral metastases" ], "offsets": [ [ 207, 226 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T14", "type": "Condition", "text": [ "cerebrovascular accident" ], "offsets": [ [ 228, 252 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T15", "type": "Condition", "text": [ "seizure disorder" ], "offsets": [ [ 275, 291 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T16", "type": "Condition", "text": [ "schizophrenia" ], "offsets": [ [ 293, 306 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T17", "type": "Condition", "text": [ "schizo-affective disorder" ], "offsets": [ [ 308, 333 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T18", "type": "Condition", "text": [ "dementia" ], "offsets": [ [ 335, 343 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T19", "type": "Condition", "text": [ "mental retardation" ], "offsets": [ [ 345, 363 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T20", "type": "Condition", "text": [ "major depression" ], "offsets": [ [ 368, 384 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T21", "type": "Condition", "text": [ "psychotic features" ], "offsets": [ [ 390, 408 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T22", "type": "Drug", "text": [ "depot neuroleptics" ], "offsets": [ [ 420, 438 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T23", "type": "Temporal", "text": [ "in last 12 months" ], "offsets": [ [ 439, 456 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T24", "type": "Observation", "text": [ "History" ], "offsets": [ [ 183, 190 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T25", "type": "Scope", "text": [ "craniotomy, cerebral metastases, cerebrovascular accident; current diagnosis of seizure disorder, schizophrenia, schizo-affective disorder, dementia, mental retardation, or major depression with psychotic features; or use of depot neuroleptics in last 12 months" ], "offsets": [ [ 195, 456 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T26", "type": "Condition", "text": [ "thyroid disorders" ], "offsets": [ [ 471, 488 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T27", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 458, 470 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T29", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 583, 588 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T30", "type": "Qualifier", "text": [ "Chronic" ], "offsets": [ [ 572, 579 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T31", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 589, 593 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T32", "type": "Scope", "text": [ "Chronic or acute" ], "offsets": [ [ 572, 588 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T33", "type": "Drug", "text": [ "prescription pain medication" ], "offsets": [ [ 604, 632 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T34", "type": "Drug", "text": [ "narcotic" ], "offsets": [ [ 637, 645 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T35", "type": "Drug", "text": [ "synthetic narcotic" ], "offsets": [ [ 649, 667 ] ], "normalized": [] }, { "id": "NCT03328052_exc_T36", "type": "Scope", "text": [ "narcotic or synthetic narcotic" ], "offsets": [ [ 637, 667 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03328052_exc_R1", "type": "Has_scope", "arg1_id": "NCT03328052_exc_T2", "arg2_id": "NCT03328052_exc_T5", "normalized": [] }, { "id": "NCT03328052_exc_R2", "type": "AND", "arg1_id": "NCT03328052_exc_T10", "arg2_id": "NCT03328052_exc_T9", "normalized": [] }, { "id": "NCT03328052_exc_R3", "type": "AND", "arg1_id": "NCT03328052_exc_T11", "arg2_id": "NCT03328052_exc_T10", "normalized": [] }, { "id": "NCT03328052_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03328052_exc_T22", "arg2_id": "NCT03328052_exc_T23", "normalized": [] }, { "id": "NCT03328052_exc_R5", "type": "AND", "arg1_id": "NCT03328052_exc_T20", "arg2_id": "NCT03328052_exc_T21", "normalized": [] }, { "id": "NCT03328052_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03328052_exc_T25", "arg2_id": "NCT03328052_exc_T24", "normalized": [] }, { "id": "NCT03328052_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03328052_exc_T26", "arg2_id": "NCT03328052_exc_T27", "normalized": [] }, { "id": "NCT03328052_exc_R8", "type": "Has_scope", "arg1_id": "NCT03328052_exc_T31", "arg2_id": "NCT03328052_exc_T32", "normalized": [] }, { "id": "NCT03328052_exc_R9", "type": "AND", "arg1_id": "NCT03328052_exc_T31", "arg2_id": "NCT03328052_exc_T33", "normalized": [] }, { "id": "NCT03328052_exc_R10", "type": "Subsumes", "arg1_id": "NCT03328052_exc_T33", "arg2_id": "NCT03328052_exc_T36", "normalized": [] } ]

[ { "id": "NCT03328052_inc_text", "type": "inclusion", "text": [ "Patients with a clinical diagnosis of depression who in the judgement of their physician require medication management may be eligible for enrollment. A score of 10 or more on the PHQ-9 instrument will be required for enrollment.\nSome practices utilize the PHQ-2 and PHQ-9 are part of routine screening for depression. If the tests are performed routinely, they do not need to be repeated for study eligibility, and may be performed prior to informed consent for this study. If, however, the PHQ-9 is not routinely performed, informed consent must be performed prior to administration. Patients with a score below 10 will be considered screen failures and will not be enrolled or offered the MYnd testing.\nPatients with non-psychotic comorbid conditions may be included.\nPatients must be either medication treatment naïve for behavioral illnesses or have no active medication treatments for at least 1 month prior to enrollment. Prohibited medications at the time of enrollment will include stimulants, benzodiazepines and THC. Prior therapy with these agents is permitted with a washout of >30 days.\nPatients must have private medical insurance coverage through Horizon Blue Cross Blue Shield. This is limited to insured commercial members, including HMO, and excluding, for the avoidance of doubt, members of self-insured customers or Medicare or Medicaid programs.\n" ], "offsets": [ [ 0, 1368 ] ] } ]

[ { "id": "NCT03328052_inc_T1", "type": "Condition", "text": [ "depression" ], "offsets": [ [ 38, 48 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T2", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 97, 107 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T3", "type": "Measurement", "text": [ "PHQ-9" ], "offsets": [ [ 180, 185 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T4", "type": "Value", "text": [ "score of 10 or more" ], "offsets": [ [ 153, 172 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T6", "type": "Condition", "text": [ "n-psychotic c", "nditions m" ], "offsets": [ [ 722, 735 ], [ 745, 755 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T7", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 795, 805 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T8", "type": "Condition", "text": [ "behavioral illnesses" ], "offsets": [ [ 826, 846 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T9", "type": "Negation", "text": [ "naïve" ], "offsets": [ [ 816, 821 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T10", "type": "Negation", "text": [ "no" ], "offsets": [ [ 855, 857 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T11", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 858, 864 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T12", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 865, 875 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T13", "type": "Temporal", "text": [ "for at least 1 month prior to enrollment" ], "offsets": [ [ 887, 927 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T14", "type": "Drug", "text": [ "benzodiazepines" ], "offsets": [ [ 1003, 1018 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T15", "type": "Drug", "text": [ "THC" ], "offsets": [ [ 1023, 1026 ] ], "normalized": [] }, { "id": "NCT03328052_inc_T16", "type": "Drug", "text": [ "stimulants" ], "offsets": [ [ 991, 1001 ] ], "normalized": [] } ]

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[ { "id": "NCT03328052_inc_R1", "type": "AND", "arg1_id": "NCT03328052_inc_T1", "arg2_id": "NCT03328052_inc_T2", "normalized": [] }, { "id": "NCT03328052_inc_R2", "type": "Has_value", "arg1_id": "NCT03328052_inc_T3", "arg2_id": "NCT03328052_inc_T4", "normalized": [] }, { "id": "NCT03328052_inc_R3", "type": "AND", "arg1_id": "NCT03328052_inc_T3", "arg2_id": "NCT03328052_inc_T1", "normalized": [] }, { "id": "NCT03328052_inc_R4", "type": "Has_negation", "arg1_id": "NCT03328052_inc_T7", "arg2_id": "NCT03328052_inc_T9", "normalized": [] }, { "id": "NCT03328052_inc_R5", "type": "AND", "arg1_id": "NCT03328052_inc_T8", "arg2_id": "NCT03328052_inc_T7", "normalized": [] }, { "id": "NCT03328052_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03328052_inc_T12", "arg2_id": "NCT03328052_inc_T11", "normalized": [] }, { "id": "NCT03328052_inc_R7", "type": "Has_negation", "arg1_id": "NCT03328052_inc_T12", "arg2_id": "NCT03328052_inc_T10", "normalized": [] }, { "id": "NCT03328052_inc_R8", "type": "Has_temporal", "arg1_id": "NCT03328052_inc_T12", "arg2_id": "NCT03328052_inc_T13", "normalized": [] } ]

[ { "id": "NCT03329456_exc_text", "type": "exclusion", "text": [ "Exclusion criteria are pregnancy, patients with contraindications to regional anesthesia, allergy to LAs, patients taking opioids regularly due to chronic pain, use of anticoagulation drugs other than acetylsalicylic acid or dipyridamole, atrioventricular block, diabetes.\n" ], "offsets": [ [ 0, 273 ] ] } ]

[ { "id": "NCT03329456_exc_T1", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 23, 32 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T2", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 48, 65 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T3", "type": "Procedure", "text": [ "regional anesthesia" ], "offsets": [ [ 69, 88 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T4", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 90, 97 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T5", "type": "Drug", "text": [ "LAs" ], "offsets": [ [ 101, 104 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T6", "type": "Drug", "text": [ "opioids" ], "offsets": [ [ 122, 129 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T7", "type": "Multiplier", "text": [ "regularly" ], "offsets": [ [ 130, 139 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T8", "type": "Condition", "text": [ "chronic pain" ], "offsets": [ [ 147, 159 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T9", "type": "Drug", "text": [ "anticoagulation drugs" ], "offsets": [ [ 168, 189 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T10", "type": "Drug", "text": [ "acetylsalicylic acid" ], "offsets": [ [ 201, 221 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T11", "type": "Drug", "text": [ "dipyridamole" ], "offsets": [ [ 225, 237 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T12", "type": "Condition", "text": [ "atrioventricular block" ], "offsets": [ [ 239, 261 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T13", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 263, 271 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T14", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 190, 200 ] ], "normalized": [] }, { "id": "NCT03329456_exc_T15", "type": "Scope", "text": [ "acetylsalicylic acid or dipyridamole" ], "offsets": [ [ 201, 237 ] ], "normalized": [] } ]

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[ { "id": "NCT03329456_exc_R1", "type": "AND", "arg1_id": "NCT03329456_exc_T4", "arg2_id": "NCT03329456_exc_T5", "normalized": [] }, { "id": "NCT03329456_exc_R2", "type": "AND", "arg1_id": "NCT03329456_exc_T6", "arg2_id": "NCT03329456_exc_T8", "normalized": [] }, { "id": "NCT03329456_exc_R3", "type": "Has_multiplier", "arg1_id": "NCT03329456_exc_T6", "arg2_id": "NCT03329456_exc_T7", "normalized": [] }, { "id": "NCT03329456_exc_R4", "type": "Has_negation", "arg1_id": "NCT03329456_exc_T15", "arg2_id": "NCT03329456_exc_T14", "normalized": [] }, { "id": "NCT03329456_exc_R5", "type": "Has_scope", "arg1_id": "NCT03329456_exc_T9", "arg2_id": "NCT03329456_exc_T15", "normalized": [] }, { "id": "NCT03329456_exc_R6", "type": "AND", "arg1_id": "NCT03329456_exc_T2", "arg2_id": "NCT03329456_exc_T3", "normalized": [] } ]

[ { "id": "NCT03329456_inc_text", "type": "inclusion", "text": [ ". Inclusion criteria are American Society of Anesthesiologists (ASA) physical status I-III, age between 18 and 70 years and body mass index (BMI) between 20 and 35 kg/m2.\n" ], "offsets": [ [ 0, 171 ] ] } ]

[ { "id": "NCT03329456_inc_T1", "type": "Measurement", "text": [ "American Society of Anesthesiologists", "physical status" ], "offsets": [ [ 25, 62 ], [ 69, 84 ] ], "normalized": [] }, { "id": "NCT03329456_inc_T2", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 64, 67 ] ], "normalized": [] }, { "id": "NCT03329456_inc_T3", "type": "Value", "text": [ "I-III" ], "offsets": [ [ 85, 90 ] ], "normalized": [] }, { "id": "NCT03329456_inc_T4", "type": "Person", "text": [ "age" ], "offsets": [ [ 92, 95 ] ], "normalized": [] }, { "id": "NCT03329456_inc_T5", "type": "Value", "text": [ "between 18 and 70 years" ], "offsets": [ [ 96, 119 ] ], "normalized": [] }, { "id": "NCT03329456_inc_T6", "type": "Measurement", "text": [ "body mass index" ], "offsets": [ [ 124, 139 ] ], "normalized": [] }, { "id": "NCT03329456_inc_T7", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 141, 144 ] ], "normalized": [] }, { "id": "NCT03329456_inc_T8", "type": "Value", "text": [ "between 20 and 35 kg/m2" ], "offsets": [ [ 146, 169 ] ], "normalized": [] } ]

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[ { "id": "NCT03329456_inc_R1", "type": "Subsumes", "arg1_id": "NCT03329456_inc_T1", "arg2_id": "NCT03329456_inc_T2", "normalized": [] }, { "id": "NCT03329456_inc_R2", "type": "Has_value", "arg1_id": "NCT03329456_inc_T1", "arg2_id": "NCT03329456_inc_T3", "normalized": [] }, { "id": "NCT03329456_inc_R3", "type": "Has_value", "arg1_id": "NCT03329456_inc_T4", "arg2_id": "NCT03329456_inc_T5", "normalized": [] }, { "id": "NCT03329456_inc_R4", "type": "Subsumes", "arg1_id": "NCT03329456_inc_T6", "arg2_id": "NCT03329456_inc_T7", "normalized": [] }, { "id": "NCT03329456_inc_R5", "type": "Has_value", "arg1_id": "NCT03329456_inc_T6", "arg2_id": "NCT03329456_inc_T8", "normalized": [] } ]

[ { "id": "NCT03333655_exc_text", "type": "exclusion", "text": [ "Participants taking CPI combination therapies with chemotherapy are not permitted.\nPregnant, lactating, or intending to become pregnant during the study.\n" ], "offsets": [ [ 0, 154 ] ] } ]

[ { "id": "NCT03333655_exc_T1", "type": "Procedure", "text": [ "CPI combination therapies" ], "offsets": [ [ 20, 45 ] ], "normalized": [] }, { "id": "NCT03333655_exc_T2", "type": "Procedure", "text": [ "chemotherapy" ], "offsets": [ [ 51, 63 ] ], "normalized": [] }, { "id": "NCT03333655_exc_T3", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 83, 91 ] ], "normalized": [] }, { "id": "NCT03333655_exc_T4", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 93, 102 ] ], "normalized": [] }, { "id": "NCT03333655_exc_T5", "type": "Mood", "text": [ "intending to become" ], "offsets": [ [ 107, 126 ] ], "normalized": [] }, { "id": "NCT03333655_exc_T6", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 127, 135 ] ], "normalized": [] }, { "id": "NCT03333655_exc_T7", "type": "Temporal", "text": [ "during the study" ], "offsets": [ [ 136, 152 ] ], "normalized": [] } ]

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[ { "id": "NCT03333655_exc_R1", "type": "Has_mood", "arg1_id": "NCT03333655_exc_T6", "arg2_id": "NCT03333655_exc_T5", "normalized": [] }, { "id": "NCT03333655_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03333655_exc_T6", "arg2_id": "NCT03333655_exc_T7", "normalized": [] } ]

[ { "id": "NCT03333655_inc_text", "type": "inclusion", "text": [ "Response assessment of complete response (CR), partial response (PR), long stable disease (SD) for >3 months with a cancer immunotherapy treatment for metastatic cancer or hematologic malignancies either through a marketed CPI or through participation in a Roche/Genentech CPI clinical trial.\nAvailability of tumor biopsy material extracted and preserved by the investigating site.\n" ], "offsets": [ [ 0, 382 ] ] } ]

[ { "id": "NCT03333655_inc_T1", "type": "Measurement", "text": [ "Response assessment" ], "offsets": [ [ 0, 19 ] ], "normalized": [] }, { "id": "NCT03333655_inc_T2", "type": "Value", "text": [ "complete response (CR)" ], "offsets": [ [ 23, 45 ] ], "normalized": [] }, { "id": "NCT03333655_inc_T3", "type": "Value", "text": [ "partial response (PR)" ], "offsets": [ [ 47, 68 ] ], "normalized": [] }, { "id": "NCT03333655_inc_T4", "type": "Value", "text": [ "long stable disease (SD)" ], "offsets": [ [ 70, 94 ] ], "normalized": [] }, { "id": "NCT03333655_inc_T5", "type": "Temporal", "text": [ "for >3 months" ], "offsets": [ [ 95, 108 ] ], "normalized": [] }, { "id": "NCT03333655_inc_T6", "type": "Scope", "text": [ "complete response (CR), partial response (PR), long stable disease (SD)" ], "offsets": [ [ 23, 94 ] ], "normalized": [] }, { "id": "NCT03333655_inc_T7", "type": "Qualifier", "text": [ "cancer" ], "offsets": [ [ 116, 122 ] ], "normalized": [] }, { "id": "NCT03333655_inc_T8", "type": "Procedure", "text": [ "immunotherapy treatment" ], "offsets": [ [ 123, 146 ] ], "normalized": [] }, { "id": "NCT03333655_inc_T9", "type": "Condition", "text": [ "metastatic cancer" ], "offsets": [ [ 151, 168 ] ], "normalized": [] }, { "id": "NCT03333655_inc_T10", "type": "Condition", "text": [ "hematologic malignancies" ], "offsets": [ [ 172, 196 ] ], "normalized": [] }, { "id": "NCT03333655_inc_T11", "type": "Procedure", "text": [ "marketed CPI" ], "offsets": [ [ 214, 226 ] ], "normalized": [] }, { "id": "NCT03333655_inc_T12", "type": "Observation", "text": [ "participation in a Roche/Genentech CPI clinical trial" ], "offsets": [ [ 238, 291 ] ], "normalized": [] }, { "id": "NCT03333655_inc_T13", "type": "Scope", "text": [ "metastatic cancer or hematologic malignancies" ], "offsets": [ [ 151, 196 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03333655_inc_R1", "type": "Has_scope", "arg1_id": "NCT03333655_inc_T1", "arg2_id": "NCT03333655_inc_T6", "normalized": [] }, { "id": "NCT03333655_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03333655_inc_T6", "arg2_id": "NCT03333655_inc_T5", "normalized": [] }, { "id": "NCT03333655_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03333655_inc_T8", "arg2_id": "NCT03333655_inc_T7", "normalized": [] }, { "id": "NCT03333655_inc_R4", "type": "Has_scope", "arg1_id": "NCT03333655_inc_T8", "arg2_id": "NCT03333655_inc_T13", "normalized": [] } ]

[ { "id": "NCT03335436_exc_text", "type": "exclusion", "text": [ "use illicit drugs or relapse during the last trimester of pregnancy\npositive drug screen at the time of delivery\nallergies to any medications used in the study\ntaking prescribed gabapentin at the time of admission for CD\ncontraindications to neuraxial anesthesia or require general anesthesia for CD\ndesignated ASA physical status 4 or above\n" ], "offsets": [ [ 0, 342 ] ] } ]

[ { "id": "NCT03335436_exc_T1", "type": "Drug", "text": [ "illicit drugs" ], "offsets": [ [ 4, 17 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T2", "type": "Condition", "text": [ "relapse" ], "offsets": [ [ 21, 28 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T3", "type": "Temporal", "text": [ "during the last trimester of pregnancy" ], "offsets": [ [ 29, 67 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T4", "type": "Reference_point", "text": [ "the last trimester of pregnancy" ], "offsets": [ [ 36, 67 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T5", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 58, 67 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T6", "type": "Qualifier", "text": [ "last trimester" ], "offsets": [ [ 40, 54 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T7", "type": "Scope", "text": [ "illicit drugs or relapse" ], "offsets": [ [ 4, 28 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T8", "type": "Measurement", "text": [ "drug screen" ], "offsets": [ [ 77, 88 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T9", "type": "Value", "text": [ "positive" ], "offsets": [ [ 68, 76 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T10", "type": "Temporal", "text": [ "at the time of delivery" ], "offsets": [ [ 89, 112 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T11", "type": "Reference_point", "text": [ "the time of delivery" ], "offsets": [ [ 92, 112 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T12", "type": "Procedure", "text": [ "delivery" ], "offsets": [ [ 104, 112 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T13", "type": "Condition", "text": [ "allergies" ], "offsets": [ [ 113, 122 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T14", "type": "Drug", "text": [ "medications used in the study" ], "offsets": [ [ 130, 159 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T15", "type": "Drug", "text": [ "gabapentin" ], "offsets": [ [ 178, 188 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T16", "type": "Qualifier", "text": [ "prescribed" ], "offsets": [ [ 167, 177 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T17", "type": "Temporal", "text": [ "at the time of admission for CD" ], "offsets": [ [ 189, 220 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T18", "type": "Reference_point", "text": [ "admission for CD" ], "offsets": [ [ 204, 220 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T19", "type": "Procedure", "text": [ "admission" ], "offsets": [ [ 204, 213 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T20", "type": "Procedure", "text": [ "CD" ], "offsets": [ [ 218, 220 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T21", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 221, 238 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T22", "type": "Procedure", "text": [ "neuraxial anesthesia" ], "offsets": [ [ 242, 262 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T23", "type": "Mood", "text": [ "require" ], "offsets": [ [ 266, 273 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T24", "type": "Procedure", "text": [ "general anesthesia" ], "offsets": [ [ 274, 292 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T25", "type": "Procedure", "text": [ "CD" ], "offsets": [ [ 297, 299 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T26", "type": "Measurement", "text": [ "ASA physical status" ], "offsets": [ [ 311, 330 ] ], "normalized": [] }, { "id": "NCT03335436_exc_T27", "type": "Value", "text": [ "4 or above" ], "offsets": [ [ 331, 341 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03335436_exc_R1", "type": "Has_index", "arg1_id": "NCT03335436_exc_T3", "arg2_id": "NCT03335436_exc_T4", "normalized": [] }, { "id": "NCT03335436_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03335436_exc_T5", "arg2_id": "NCT03335436_exc_T6", "normalized": [] }, { "id": "NCT03335436_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03335436_exc_T7", "arg2_id": "NCT03335436_exc_T3", "normalized": [] }, { "id": "NCT03335436_exc_R5", "type": "Has_index", "arg1_id": "NCT03335436_exc_T10", "arg2_id": "NCT03335436_exc_T11", "normalized": [] }, { "id": "NCT03335436_exc_R7", "type": "Has_value", "arg1_id": "NCT03335436_exc_T8", "arg2_id": "NCT03335436_exc_T9", "normalized": [] }, { "id": "NCT03335436_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03335436_exc_T8", "arg2_id": "NCT03335436_exc_T10", "normalized": [] }, { "id": "NCT03335436_exc_R9", "type": "AND", "arg1_id": "NCT03335436_exc_T13", "arg2_id": "NCT03335436_exc_T14", "normalized": [] }, { "id": "NCT03335436_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03335436_exc_T15", "arg2_id": "NCT03335436_exc_T16", "normalized": [] }, { "id": "NCT03335436_exc_R11", "type": "AND", "arg1_id": "NCT03335436_exc_T19", "arg2_id": "NCT03335436_exc_T20", "normalized": [] }, { "id": "NCT03335436_exc_R13", "type": "Has_index", "arg1_id": "NCT03335436_exc_T17", "arg2_id": "NCT03335436_exc_T18", "normalized": [] }, { "id": "NCT03335436_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03335436_exc_T15", "arg2_id": "NCT03335436_exc_T17", "normalized": [] }, { "id": "NCT03335436_exc_R15", "type": "AND", "arg1_id": "NCT03335436_exc_T24", "arg2_id": "NCT03335436_exc_T25", "normalized": [] }, { "id": "NCT03335436_exc_R16", "type": "Has_mood", "arg1_id": "NCT03335436_exc_T24", "arg2_id": "NCT03335436_exc_T23", "normalized": [] }, { "id": "NCT03335436_exc_R17", "type": "AND", "arg1_id": "NCT03335436_exc_T21", "arg2_id": "NCT03335436_exc_T22", "normalized": [] }, { "id": "NCT03335436_exc_R18", "type": "Has_value", "arg1_id": "NCT03335436_exc_T26", "arg2_id": "NCT03335436_exc_T27", "normalized": [] } ]

[ { "id": "NCT03335436_inc_text", "type": "inclusion", "text": [ "singleton, term pregnancy\ncurrently on buprenorphine maintenance therapy\nscheduled for elective CD under spinal anesthesia\n" ], "offsets": [ [ 0, 123 ] ] } ]

[ { "id": "NCT03335436_inc_T1", "type": "Qualifier", "text": [ "singleton" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT03335436_inc_T2", "type": "Qualifier", "text": [ "term" ], "offsets": [ [ 11, 15 ] ], "normalized": [] }, { "id": "NCT03335436_inc_T3", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 16, 25 ] ], "normalized": [] }, { "id": "NCT03335436_inc_T4", "type": "Drug", "text": [ "buprenorphine" ], "offsets": [ [ 39, 52 ] ], "normalized": [] }, { "id": "NCT03335436_inc_T5", "type": "Procedure", "text": [ "buprenorphine maintenance therapy" ], "offsets": [ [ 39, 72 ] ], "normalized": [] }, { "id": "NCT03335436_inc_T6", "type": "Temporal", "text": [ "currently" ], "offsets": [ [ 26, 35 ] ], "normalized": [] }, { "id": "NCT03335436_inc_T7", "type": "Mood", "text": [ "scheduled for" ], "offsets": [ [ 73, 86 ] ], "normalized": [] }, { "id": "NCT03335436_inc_T8", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 87, 95 ] ], "normalized": [] }, { "id": "NCT03335436_inc_T9", "type": "Procedure", "text": [ "CD" ], "offsets": [ [ 96, 98 ] ], "normalized": [] }, { "id": "NCT03335436_inc_T10", "type": "Procedure", "text": [ "spinal anesthesia" ], "offsets": [ [ 105, 122 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03335436_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03335436_inc_T3", "arg2_id": "NCT03335436_inc_T2", "normalized": [] }, { "id": "NCT03335436_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03335436_inc_T3", "arg2_id": "NCT03335436_inc_T1", "normalized": [] }, { "id": "NCT03335436_inc_R4", "type": "Has_temporal", "arg1_id": "NCT03335436_inc_T5", "arg2_id": "NCT03335436_inc_T6", "normalized": [] }, { "id": "NCT03335436_inc_R5", "type": "AND", "arg1_id": "NCT03335436_inc_T9", "arg2_id": "NCT03335436_inc_T10", "normalized": [] }, { "id": "NCT03335436_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03335436_inc_T9", "arg2_id": "NCT03335436_inc_T8", "normalized": [] }, { "id": "NCT03335436_inc_R7", "type": "Has_mood", "arg1_id": "NCT03335436_inc_T9", "arg2_id": "NCT03335436_inc_T7", "normalized": [] } ]

[ { "id": "NCT03335904_exc_text", "type": "exclusion", "text": [ "history of hypertension\nknown impaired renal function\nliver disease\nheart failure\nmyocardial infarction\ncoronary artery disease\nsmoked within the past year\napnea hypopnea index > 5 events per hour\n" ], "offsets": [ [ 0, 197 ] ] } ]

[ { "id": "NCT03335904_exc_T1", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 11, 23 ] ], "normalized": [] }, { "id": "NCT03335904_exc_T2", "type": "Observation", "text": [ "history" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03335904_exc_T3", "type": "Condition", "text": [ "impaired renal function" ], "offsets": [ [ 30, 53 ] ], "normalized": [] }, { "id": "NCT03335904_exc_T4", "type": "Condition", "text": [ "liver disease" ], "offsets": [ [ 54, 67 ] ], "normalized": [] }, { "id": "NCT03335904_exc_T5", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 68, 81 ] ], "normalized": [] }, { "id": "NCT03335904_exc_T6", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 82, 103 ] ], "normalized": [] }, { "id": "NCT03335904_exc_T7", "type": "Condition", "text": [ "coronary artery disease" ], "offsets": [ [ 104, 127 ] ], "normalized": [] }, { "id": "NCT03335904_exc_T8", "type": "Observation", "text": [ "smoked" ], "offsets": [ [ 128, 134 ] ], "normalized": [] }, { "id": "NCT03335904_exc_T9", "type": "Temporal", "text": [ "within the past year" ], "offsets": [ [ 135, 155 ] ], "normalized": [] }, { "id": "NCT03335904_exc_T10", "type": "Measurement", "text": [ "apnea hypopnea index" ], "offsets": [ [ 156, 176 ] ], "normalized": [] }, { "id": "NCT03335904_exc_T11", "type": "Value", "text": [ "> 5 events per hour" ], "offsets": [ [ 177, 196 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03335904_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03335904_exc_T1", "arg2_id": "NCT03335904_exc_T2", "normalized": [] }, { "id": "NCT03335904_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03335904_exc_T8", "arg2_id": "NCT03335904_exc_T9", "normalized": [] }, { "id": "NCT03335904_exc_R3", "type": "Has_value", "arg1_id": "NCT03335904_exc_T10", "arg2_id": "NCT03335904_exc_T11", "normalized": [] } ]

[ { "id": "NCT03335904_inc_text", "type": "inclusion", "text": [ "normotensive\nforced expiratory volume in 1s : forced vital capacity ratio > 0.75\nno medical history of cardiovascular and respiratory disease\nnot taking medications other than oral contraceptives\nfree from sleep apnea\nbody mass index less than 30 kg/m2\n" ], "offsets": [ [ 0, 253 ] ] } ]

[ { "id": "NCT03335904_inc_T1", "type": "Condition", "text": [ "normotensive" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T2", "type": "Measurement", "text": [ "forced expiratory volume in 1s : forced vital capacity ratio" ], "offsets": [ [ 13, 73 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T3", "type": "Value", "text": [ "> 0.75" ], "offsets": [ [ 74, 80 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T4", "type": "Negation", "text": [ "no" ], "offsets": [ [ 81, 83 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T5", "type": "Observation", "text": [ "medical history" ], "offsets": [ [ 84, 99 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T6", "type": "Condition", "text": [ "rdiovascular a", "sease\nn" ], "offsets": [ [ 105, 119 ], [ 136, 143 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T7", "type": "Condition", "text": [ "respiratory disease" ], "offsets": [ [ 122, 141 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T8", "type": "Scope", "text": [ "cardiovascular and respiratory disease" ], "offsets": [ [ 103, 141 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T9", "type": "Negation", "text": [ "not" ], "offsets": [ [ 142, 145 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T10", "type": "Drug", "text": [ "medications" ], "offsets": [ [ 153, 164 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T11", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 165, 175 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T12", "type": "Drug", "text": [ "oral contraceptives" ], "offsets": [ [ 176, 195 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T13", "type": "Scope", "text": [ "medications other than oral contraceptives" ], "offsets": [ [ 153, 195 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T14", "type": "Negation", "text": [ "free from" ], "offsets": [ [ 196, 205 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T15", "type": "Condition", "text": [ "sleep apnea" ], "offsets": [ [ 206, 217 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T16", "type": "Measurement", "text": [ "body mass index" ], "offsets": [ [ 218, 233 ] ], "normalized": [] }, { "id": "NCT03335904_inc_T17", "type": "Value", "text": [ "less than 30 kg/m2" ], "offsets": [ [ 234, 252 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03335904_inc_R1", "type": "Has_value", "arg1_id": "NCT03335904_inc_T2", "arg2_id": "NCT03335904_inc_T3", "normalized": [] }, { "id": "NCT03335904_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03335904_inc_T8", "arg2_id": "NCT03335904_inc_T5", "normalized": [] }, { "id": "NCT03335904_inc_R3", "type": "Has_negation", "arg1_id": "NCT03335904_inc_T8", "arg2_id": "NCT03335904_inc_T4", "normalized": [] }, { "id": "NCT03335904_inc_R4", "type": "Has_negation", "arg1_id": "NCT03335904_inc_T12", "arg2_id": "NCT03335904_inc_T11", "normalized": [] }, { "id": "NCT03335904_inc_R5", "type": "AND", "arg1_id": "NCT03335904_inc_T10", "arg2_id": "NCT03335904_inc_T12", "normalized": [] }, { "id": "NCT03335904_inc_R6", "type": "Has_negation", "arg1_id": "NCT03335904_inc_T13", "arg2_id": "NCT03335904_inc_T9", "normalized": [] }, { "id": "NCT03335904_inc_R7", "type": "Has_negation", "arg1_id": "NCT03335904_inc_T15", "arg2_id": "NCT03335904_inc_T14", "normalized": [] }, { "id": "NCT03335904_inc_R8", "type": "Has_value", "arg1_id": "NCT03335904_inc_T16", "arg2_id": "NCT03335904_inc_T17", "normalized": [] } ]

[ { "id": "NCT03336801_exc_text", "type": "exclusion", "text": [ "American Association of Anesthesiology class 1-3\nAmerican Heart Association class >3\nBMI >37\nInsulin treated diabetes\nPregnancy or breast feeding\nSensistivity/allergy against anesthetic agents\nInadequate understanding about the study\nDepressed kidney function and/or AKI\nDepressed liver function\nGenetic malignant hyperthermia\n" ], "offsets": [ [ 0, 327 ] ] } ]

[ { "id": "NCT03336801_exc_T1", "type": "Measurement", "text": [ "American Association of Anesthesiology class" ], "offsets": [ [ 0, 44 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T2", "type": "Value", "text": [ "1-3" ], "offsets": [ [ 45, 48 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T3", "type": "Measurement", "text": [ "American Heart Association class" ], "offsets": [ [ 49, 81 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T4", "type": "Value", "text": [ ">3" ], "offsets": [ [ 82, 84 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T5", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 85, 88 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T6", "type": "Value", "text": [ ">37" ], "offsets": [ [ 89, 92 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T7", "type": "Qualifier", "text": [ "Insulin treated" ], "offsets": [ [ 93, 108 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T8", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 109, 117 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T9", "type": "Drug", "text": [ "Insulin" ], "offsets": [ [ 93, 100 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T10", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 118, 127 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T11", "type": "Observation", "text": [ "breast feeding" ], "offsets": [ [ 131, 145 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T12", "type": "Condition", "text": [ "Sensistivity" ], "offsets": [ [ 146, 158 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T13", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 159, 166 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T14", "type": "Drug", "text": [ "anesthetic agents" ], "offsets": [ [ 175, 192 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T15", "type": "Scope", "text": [ "Sensistivity/allergy" ], "offsets": [ [ 146, 166 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T16", "type": "Observation", "text": [ "Inadequate understanding about the study" ], "offsets": [ [ 193, 233 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T17", "type": "Value", "text": [ "Depressed" ], "offsets": [ [ 234, 243 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T18", "type": "Measurement", "text": [ "kidney function" ], "offsets": [ [ 244, 259 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T19", "type": "Condition", "text": [ "AKI" ], "offsets": [ [ 267, 270 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T20", "type": "Condition", "text": [ "Depressed kidney function" ], "offsets": [ [ 234, 259 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T21", "type": "Value", "text": [ "Depressed" ], "offsets": [ [ 271, 280 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T22", "type": "Measurement", "text": [ "liver function" ], "offsets": [ [ 281, 295 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T23", "type": "Condition", "text": [ "Depressed liver function" ], "offsets": [ [ 271, 295 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T24", "type": "Qualifier", "text": [ "Genetic" ], "offsets": [ [ 296, 303 ] ], "normalized": [] }, { "id": "NCT03336801_exc_T25", "type": "Condition", "text": [ "malignant hyperthermia" ], "offsets": [ [ 304, 326 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03336801_exc_R1", "type": "Has_value", "arg1_id": "NCT03336801_exc_T1", "arg2_id": "NCT03336801_exc_T2", "normalized": [] }, { "id": "NCT03336801_exc_R2", "type": "Has_value", "arg1_id": "NCT03336801_exc_T3", "arg2_id": "NCT03336801_exc_T4", "normalized": [] }, { "id": "NCT03336801_exc_R3", "type": "Has_value", "arg1_id": "NCT03336801_exc_T5", "arg2_id": "NCT03336801_exc_T6", "normalized": [] }, { "id": "NCT03336801_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03336801_exc_T8", "arg2_id": "NCT03336801_exc_T7", "normalized": [] }, { "id": "NCT03336801_exc_R6", "type": "AND", "arg1_id": "NCT03336801_exc_T15", "arg2_id": "NCT03336801_exc_T14", "normalized": [] }, { "id": "NCT03336801_exc_R7", "type": "Has_value", "arg1_id": "NCT03336801_exc_T18", "arg2_id": "NCT03336801_exc_T17", "normalized": [] }, { "id": "NCT03336801_exc_R9", "type": "Has_value", "arg1_id": "NCT03336801_exc_T22", "arg2_id": "NCT03336801_exc_T21", "normalized": [] }, { "id": "NCT03336801_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT03336801_exc_T25", "arg2_id": "NCT03336801_exc_T24", "normalized": [] } ]

[ { "id": "NCT03336801_inc_text", "type": "inclusion", "text": [ "Scheduled back surgery\n" ], "offsets": [ [ 0, 23 ] ] } ]

[ { "id": "NCT03336801_inc_T1", "type": "Mood", "text": [ "Scheduled" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT03336801_inc_T2", "type": "Procedure", "text": [ "back surgery" ], "offsets": [ [ 10, 22 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03336801_inc_R1", "type": "Has_mood", "arg1_id": "NCT03336801_inc_T2", "arg2_id": "NCT03336801_inc_T1", "normalized": [] } ]

[ { "id": "NCT03337503_exc_text", "type": "exclusion", "text": [ "Acute pain (less than 3 months in duration)\nPrevious serious adverse event or hypersensitivity to cannabis or cannabinoids\nInability to understand and comply with the instructions of the study\nPresence of significant cardiac disease (history of unstable ischemic heart disease, heart failure, severe and uncontrolled hypertension) that, in the opinion of the investigator, would put the patient at risk of a clinically significant arrhythmia or myocardial infarction\nCurrent substance use disorder according to the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM 5)\nLife-time history of dependence on cannabis or diagnosis of cannabis use disorder (CUD) according to the DSM 5\nLife-time history of DSM 5 schizophrenia, bipolar disorder, or previous psychosis with or intolerance to cannabinoids\nCurrent or history of suicidal ideation\nPregnant, breast-feeding or female patients of child-bearing potential and male patients whose partner is of child-bearing potential, unless willing to ensure that they or their partner use effective contraception\nHepatic impairment (aspartate aminotransferase more than three times normal) or renal function impairment (serum creatinine level >133 µmol/L, Estimated Glomerular Filtration Rate (eGFR) <60)\nCognitive impairment according to MiniCog\nThe patient is currently using or has used cannabinoid based medications within 90 days of study entry and is unwilling to abstain for the duration of the study\nPositive urine drug screen for cannabinoids and other potential abuse substances (e.g. alcohol, cocaine, amphetamines and methamphetamines, unprescribed opioids)\nParticipation in another clinical trial within 30 days of enrolment in our trial\n" ], "offsets": [ [ 0, 1712 ] ] } ]

[ { "id": "NCT03337503_exc_T1", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 6, 10 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T2", "type": "Measurement", "text": [ "duration" ], "offsets": [ [ 34, 42 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T3", "type": "Value", "text": [ "less than 3 months" ], "offsets": [ [ 12, 30 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T4", "type": "Qualifier", "text": [ "Acute" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T5", "type": "Scope", "text": [ "less than 3 months in duration" ], "offsets": [ [ 12, 42 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T6", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 78, 94 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T7", "type": "Drug", "text": [ "cannabis" ], "offsets": [ [ 98, 106 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T8", "type": "Drug", "text": [ "cannabinoids" ], "offsets": [ [ 110, 122 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T9", "type": "Scope", "text": [ "cannabis or cannabinoids" ], "offsets": [ [ 98, 122 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T10", "type": "Condition", "text": [ "adverse event" ], "offsets": [ [ 61, 74 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T11", "type": "Qualifier", "text": [ "serious" ], "offsets": [ [ 53, 60 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T13", "type": "Condition", "text": [ "cardiac disease" ], "offsets": [ [ 217, 232 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T14", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 205, 216 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T15", "type": "Condition", "text": [ "unstable ischemic heart disease" ], "offsets": [ [ 245, 276 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T16", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 278, 291 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T17", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 293, 299 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T18", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 304, 316 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T19", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 317, 329 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T20", "type": "Observation", "text": [ "history" ], "offsets": [ [ 234, 241 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T21", "type": "Scope", "text": [ "unstable ischemic heart disease, heart failure, severe and uncontrolled hypertension" ], "offsets": [ [ 245, 329 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T22", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 408, 430 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T23", "type": "Condition", "text": [ "arrhythmia" ], "offsets": [ [ 431, 441 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T24", "type": "Condition", "text": [ "myocardial infarction" ], "offsets": [ [ 445, 466 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T25", "type": "Scope", "text": [ "arrhythmia or myocardial infarction" ], "offsets": [ [ 431, 466 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T26", "type": "Mood", "text": [ "at risk of" ], "offsets": [ [ 395, 405 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T27", "type": "Scope", "text": [ "significant cardiac disease" ], "offsets": [ [ 205, 232 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T28", "type": "Condition", "text": [ "substance use disorder" ], "offsets": [ [ 475, 497 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T29", "type": "Qualifier", "text": [ "Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM 5)" ], "offsets": [ [ 515, 590 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T30", "type": "Condition", "text": [ "dependence on cannabis" ], "offsets": [ [ 612, 634 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T31", "type": "Condition", "text": [ "cannabis use disorder (CUD)" ], "offsets": [ [ 651, 678 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T32", "type": "Qualifier", "text": [ "DSM 5" ], "offsets": [ [ 696, 701 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T33", "type": "Qualifier", "text": [ "DSM 5" ], "offsets": [ [ 723, 728 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T34", "type": "Condition", "text": [ "schizophrenia" ], "offsets": [ [ 729, 742 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T35", "type": "Condition", "text": [ "bipolar disorder" ], "offsets": [ [ 744, 760 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T36", "type": "Condition", "text": [ "psychosis" ], "offsets": [ [ 774, 783 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T37", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 792, 803 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T38", "type": "Drug", "text": [ "cannabinoids" ], "offsets": [ [ 807, 819 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T39", "type": "Condition", "text": [ "suicidal ideation" ], "offsets": [ [ 842, 859 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T40", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 820, 827 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T41", "type": "Observation", "text": [ "history" ], "offsets": [ [ 831, 838 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T42", "type": "Scope", "text": [ "Current or history" ], "offsets": [ [ 820, 838 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T44", "type": "Condition", "text": [ "Hepatic impairment" ], "offsets": [ [ 1074, 1092 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T45", "type": "Measurement", "text": [ "Estimated Glomerular Filtration Rate (eGFR)" ], "offsets": [ [ 1217, 1260 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T46", "type": "Value", "text": [ "<60" ], "offsets": [ [ 1261, 1264 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T47", "type": "Measurement", "text": [ "aspartate aminotransferase" ], "offsets": [ [ 1094, 1120 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T48", "type": "Value", "text": [ "more than three times normal" ], "offsets": [ [ 1121, 1149 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T49", "type": "Condition", "text": [ "renal function impairment" ], "offsets": [ [ 1154, 1179 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T50", "type": "Measurement", "text": [ "serum creatinine level" ], "offsets": [ [ 1181, 1203 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T51", "type": "Value", "text": [ ">133 µmol/L" ], "offsets": [ [ 1204, 1215 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T52", "type": "Scope", "text": [ "serum creatinine level >133 µmol/L, Estimated Glomerular Filtration Rate (eGFR) <60" ], "offsets": [ [ 1181, 1264 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T53", "type": "Condition", "text": [ "Cognitive impairment" ], "offsets": [ [ 1266, 1286 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T54", "type": "Procedure", "text": [ "MiniCog" ], "offsets": [ [ 1300, 1307 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T55", "type": "Drug", "text": [ "cannabinoid based medications" ], "offsets": [ [ 1351, 1380 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T56", "type": "Temporal", "text": [ "within 90 days of study entry" ], "offsets": [ [ 1381, 1410 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T57", "type": "Measurement", "text": [ "urine drug screen" ], "offsets": [ [ 1478, 1495 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T58", "type": "Value", "text": [ "Positive" ], "offsets": [ [ 1469, 1477 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T59", "type": "Drug", "text": [ "cannabinoids" ], "offsets": [ [ 1500, 1512 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T60", "type": "Drug", "text": [ "alcohol" ], "offsets": [ [ 1556, 1563 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T61", "type": "Drug", "text": [ "cocaine" ], "offsets": [ [ 1565, 1572 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T62", "type": "Drug", "text": [ "amphetamines" ], "offsets": [ [ 1595, 1607 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T63", "type": "Drug", "text": [ "methamphetamines" ], "offsets": [ [ 1591, 1607 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T64", "type": "Drug", "text": [ "opioids" ], "offsets": [ [ 1622, 1629 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T65", "type": "Qualifier", "text": [ "unprescribed" ], "offsets": [ [ 1609, 1621 ] ], "normalized": [] }, { "id": "NCT03337503_exc_T66", "type": "Scope", "text": [ "cannabinoids and other potential abuse substances (e.g. alcohol, cocaine, amphetamines and methamphetamines, unprescribed opioids)" ], "offsets": [ [ 1500, 1630 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03337503_exc_R1", "type": "Has_value", "arg1_id": "NCT03337503_exc_T2", "arg2_id": "NCT03337503_exc_T3", "normalized": [] }, { "id": "NCT03337503_exc_R2", "type": "Subsumes", "arg1_id": "NCT03337503_exc_T4", "arg2_id": "NCT03337503_exc_T5", "normalized": [] }, { "id": "NCT03337503_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03337503_exc_T1", "arg2_id": "NCT03337503_exc_T4", "normalized": [] }, { "id": "NCT03337503_exc_R4", "type": "Has_scope", "arg1_id": "NCT03337503_exc_T6", "arg2_id": "NCT03337503_exc_T9", "normalized": [] }, { "id": "NCT03337503_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03337503_exc_T10", "arg2_id": "NCT03337503_exc_T11", "normalized": [] }, { "id": "NCT03337503_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03337503_exc_T13", "arg2_id": "NCT03337503_exc_T14", "normalized": [] }, { "id": "NCT03337503_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03337503_exc_T19", "arg2_id": "NCT03337503_exc_T18", "normalized": [] }, { "id": "NCT03337503_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03337503_exc_T19", "arg2_id": "NCT03337503_exc_T17", "normalized": [] }, { "id": "NCT03337503_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03337503_exc_T21", "arg2_id": "NCT03337503_exc_T20", "normalized": [] }, { "id": "NCT03337503_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03337503_exc_T25", "arg2_id": "NCT03337503_exc_T22", "normalized": [] }, { "id": "NCT03337503_exc_R11", "type": "Has_mood", "arg1_id": "NCT03337503_exc_T25", "arg2_id": "NCT03337503_exc_T26", "normalized": [] }, { "id": "NCT03337503_exc_R12", "type": "Subsumes", "arg1_id": "NCT03337503_exc_T27", "arg2_id": "NCT03337503_exc_T21", "normalized": [] }, { "id": "NCT03337503_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT03337503_exc_T28", "arg2_id": "NCT03337503_exc_T29", "normalized": [] }, { "id": "NCT03337503_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT03337503_exc_T31", "arg2_id": "NCT03337503_exc_T32", "normalized": [] }, { "id": "NCT03337503_exc_R15", "type": "AND", "arg1_id": "NCT03337503_exc_T37", "arg2_id": "NCT03337503_exc_T38", "normalized": [] }, { "id": "NCT03337503_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT03337503_exc_T34", "arg2_id": "NCT03337503_exc_T33", "normalized": [] }, { "id": "NCT03337503_exc_R17", "type": "Has_scope", "arg1_id": "NCT03337503_exc_T39", "arg2_id": "NCT03337503_exc_T42", "normalized": [] }, { "id": "NCT03337503_exc_R18", "type": "Has_value", "arg1_id": "NCT03337503_exc_T45", "arg2_id": "NCT03337503_exc_T46", "normalized": [] }, { "id": "NCT03337503_exc_R19", "type": "Has_value", "arg1_id": "NCT03337503_exc_T47", "arg2_id": "NCT03337503_exc_T48", "normalized": [] }, { "id": "NCT03337503_exc_R20", "type": "Has_value", "arg1_id": "NCT03337503_exc_T50", "arg2_id": "NCT03337503_exc_T51", "normalized": [] }, { "id": "NCT03337503_exc_R21", "type": "Subsumes", "arg1_id": "NCT03337503_exc_T49", "arg2_id": "NCT03337503_exc_T52", "normalized": [] }, { "id": "NCT03337503_exc_R22", "type": "Subsumes", "arg1_id": "NCT03337503_exc_T44", "arg2_id": "NCT03337503_exc_T47", "normalized": [] }, { "id": "NCT03337503_exc_R23", "type": "AND", "arg1_id": "NCT03337503_exc_T54", "arg2_id": "NCT03337503_exc_T53", "normalized": [] }, { "id": "NCT03337503_exc_R24", "type": "Has_temporal", "arg1_id": "NCT03337503_exc_T55", "arg2_id": "NCT03337503_exc_T56", "normalized": [] }, { "id": "NCT03337503_exc_R25", "type": "Has_value", "arg1_id": "NCT03337503_exc_T57", "arg2_id": "NCT03337503_exc_T58", "normalized": [] }, { "id": "NCT03337503_exc_R26", "type": "Has_qualifier", "arg1_id": "NCT03337503_exc_T64", "arg2_id": "NCT03337503_exc_T65", "normalized": [] }, { "id": "NCT03337503_exc_R27", "type": "Has_scope", "arg1_id": "NCT03337503_exc_T58", "arg2_id": "NCT03337503_exc_T66", "normalized": [] } ]

[ { "id": "NCT03337503_inc_text", "type": "inclusion", "text": [ "Written informed consent\nAdult patients (older than 18 years of age), male and female, with chronic non-cancer and cancer pain (at least 3 months in duration)\nPatients experiencing an average weekly pain intensity score greater than 4 on a 11 points NRS\nSubject agreed to follow the protocol\nNaïve cannabis patients with chronic non-cancer and cancer pain (not used cannabis in any presentation in the last 12 weeks)\nPatients receiving opioids and other concomitant pain medications should have a stable dose for the last 15 days.\nNormal cognitive status according to MiniCog\nNormal liver function (defined as aspartate aminotransferase 10-40 U/L and alanine aminotransferase 7-56 U/L)\nNormal renal function (defined as serum creatinine level <133 µmol/L and Estimated Glomerular Filtration Rate (eGFR) greater than or equal to 60)\nNegative result on ßhuman chorionic gonadotropin pregnancy test (if applicable)\nAbility to read and respond to questions in French or English.\nA male volunteer with sexual partners who are pregnant, possibly pregnant, or who could become pregnant must be surgically sterile or agrees to use one of the accepted contraceptive regimens from first drug administration until 3 months after the last drug administration.\n" ], "offsets": [ [ 0, 1248 ] ] } ]

[ { "id": "NCT03337503_inc_T2", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 25, 30 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T3", "type": "Value", "text": [ "older than 18 years" ], "offsets": [ [ 41, 60 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T4", "type": "Person", "text": [ "age" ], "offsets": [ [ 64, 67 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T5", "type": "Person", "text": [ "male" ], "offsets": [ [ 70, 74 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T6", "type": "Person", "text": [ "female" ], "offsets": [ [ 79, 85 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T7", "type": "Scope", "text": [ "older than 18 years of age" ], "offsets": [ [ 41, 67 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T8", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 92, 99 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T9", "type": "Qualifier", "text": [ "non-cancer" ], "offsets": [ [ 100, 110 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T10", "type": "Qualifier", "text": [ "cancer" ], "offsets": [ [ 115, 121 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T11", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 122, 126 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T12", "type": "Scope", "text": [ "non-cancer and cancer" ], "offsets": [ [ 100, 121 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T13", "type": "Multiplier", "text": [ "at least 3 months in duration" ], "offsets": [ [ 128, 157 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T14", "type": "Measurement", "text": [ "erage weekly pain intensity score g", " a 11 points NRS\n" ], "offsets": [ [ 186, 221 ], [ 237, 254 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T15", "type": "Value", "text": [ "greater than 4" ], "offsets": [ [ 220, 234 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T17", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 321, 328 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T18", "type": "Qualifier", "text": [ "non-cancer" ], "offsets": [ [ 329, 339 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T19", "type": "Qualifier", "text": [ "cancer" ], "offsets": [ [ 344, 350 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T20", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 351, 355 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T21", "type": "Scope", "text": [ "non-cancer and cancer" ], "offsets": [ [ 329, 350 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T22", "type": "Measurement", "text": [ "not" ], "offsets": [ [ 357, 360 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T23", "type": "Drug", "text": [ "cannabis" ], "offsets": [ [ 366, 374 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T24", "type": "Temporal", "text": [ "in the last 12 weeks" ], "offsets": [ [ 395, 415 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T25", "type": "Condition", "text": [ "Naïve cannabis" ], "offsets": [ [ 292, 306 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T26", "type": "Scope", "text": [ "not used cannabis in any presentation in the last 12 weeks" ], "offsets": [ [ 357, 415 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T27", "type": "Drug", "text": [ "opioids" ], "offsets": [ [ 436, 443 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T28", "type": "Drug", "text": [ "pain medications" ], "offsets": [ [ 466, 482 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T29", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 448, 453 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T30", "type": "Qualifier", "text": [ "stable dose" ], "offsets": [ [ 497, 508 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T31", "type": "Temporal", "text": [ "for the last 15 days" ], "offsets": [ [ 509, 529 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T32", "type": "Scope", "text": [ "opioids and other concomitant pain medications" ], "offsets": [ [ 436, 482 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T33", "type": "Procedure", "text": [ "MiniCog" ], "offsets": [ [ 568, 575 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T34", "type": "Condition", "text": [ "Normal cognitive status" ], "offsets": [ [ 531, 554 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T35", "type": "Condition", "text": [ "Normal liver function" ], "offsets": [ [ 576, 597 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T36", "type": "Measurement", "text": [ "aspartate aminotransferase" ], "offsets": [ [ 610, 636 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T37", "type": "Value", "text": [ "10-40 U/L" ], "offsets": [ [ 637, 646 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T38", "type": "Measurement", "text": [ "alanine aminotransferase" ], "offsets": [ [ 651, 675 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T39", "type": "Value", "text": [ "7-56 U/L" ], "offsets": [ [ 676, 684 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T40", "type": "Scope", "text": [ "aspartate aminotransferase 10-40 U/L and alanine aminotransferase 7-56 U/L" ], "offsets": [ [ 610, 684 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T41", "type": "Condition", "text": [ "Normal renal function" ], "offsets": [ [ 686, 707 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T42", "type": "Measurement", "text": [ "serum creatinine level" ], "offsets": [ [ 720, 742 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T43", "type": "Value", "text": [ "<133 µmol/L" ], "offsets": [ [ 743, 754 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T44", "type": "Measurement", "text": [ "Estimated Glomerular Filtration Rate (eGFR)" ], "offsets": [ [ 759, 802 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T45", "type": "Value", "text": [ "greater than or equal to 60" ], "offsets": [ [ 803, 830 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T46", "type": "Scope", "text": [ "serum creatinine level <133 µmol/L and Estimated Glomerular Filtration Rate (eGFR) greater than or equal to 60" ], "offsets": [ [ 720, 830 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T47", "type": "Value", "text": [ "Negative" ], "offsets": [ [ 832, 840 ] ], "normalized": [] }, { "id": "NCT03337503_inc_T48", "type": "Measurement", "text": [ "ßhuman chorionic gonadotropin pregnancy test" ], "offsets": [ [ 851, 895 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03337503_inc_R1", "type": "Has_value", "arg1_id": "NCT03337503_inc_T4", "arg2_id": "NCT03337503_inc_T3", "normalized": [] }, { "id": "NCT03337503_inc_R2", "type": "Subsumes", "arg1_id": "NCT03337503_inc_T2", "arg2_id": "NCT03337503_inc_T7", "normalized": [] }, { "id": "NCT03337503_inc_R3", "type": "Has_scope", "arg1_id": "NCT03337503_inc_T11", "arg2_id": "NCT03337503_inc_T12", "normalized": [] }, { "id": "NCT03337503_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03337503_inc_T11", "arg2_id": "NCT03337503_inc_T8", "normalized": [] }, { "id": "NCT03337503_inc_R5", "type": "Subsumes", "arg1_id": "NCT03337503_inc_T8", "arg2_id": "NCT03337503_inc_T13", "normalized": [] }, { "id": "NCT03337503_inc_R6", "type": "Has_value", "arg1_id": "NCT03337503_inc_T14", "arg2_id": "NCT03337503_inc_T15", "normalized": [] }, { "id": "NCT03337503_inc_R7", "type": "Has_scope", "arg1_id": "NCT03337503_inc_T20", "arg2_id": "NCT03337503_inc_T21", "normalized": [] }, { "id": "NCT03337503_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT03337503_inc_T20", "arg2_id": "NCT03337503_inc_T17", "normalized": [] }, { "id": "NCT03337503_inc_R9", "type": "Has_temporal", "arg1_id": "NCT03337503_inc_T23", "arg2_id": "NCT03337503_inc_T24", "normalized": [] }, { "id": "NCT03337503_inc_R10", "type": "AND", "arg1_id": "NCT03337503_inc_T23", "arg2_id": "NCT03337503_inc_T22", "normalized": [] }, { "id": "NCT03337503_inc_R11", "type": "Subsumes", "arg1_id": "NCT03337503_inc_T25", "arg2_id": "NCT03337503_inc_T26", "normalized": [] }, { "id": "NCT03337503_inc_R12", "type": "Has_qualifier", "arg1_id": "NCT03337503_inc_T28", "arg2_id": "NCT03337503_inc_T29", "normalized": [] }, { "id": "NCT03337503_inc_R13", "type": "Has_temporal", "arg1_id": "NCT03337503_inc_T30", "arg2_id": "NCT03337503_inc_T31", "normalized": [] }, { "id": "NCT03337503_inc_R14", "type": "Has_qualifier", "arg1_id": "NCT03337503_inc_T32", "arg2_id": "NCT03337503_inc_T30", "normalized": [] }, { "id": "NCT03337503_inc_R15", "type": "AND", "arg1_id": "NCT03337503_inc_T33", "arg2_id": "NCT03337503_inc_T34", "normalized": [] }, { "id": "NCT03337503_inc_R16", "type": "Has_value", "arg1_id": "NCT03337503_inc_T38", "arg2_id": "NCT03337503_inc_T39", "normalized": [] }, { "id": "NCT03337503_inc_R17", "type": "Has_value", "arg1_id": "NCT03337503_inc_T36", "arg2_id": "NCT03337503_inc_T37", "normalized": [] }, { "id": "NCT03337503_inc_R18", "type": "Subsumes", "arg1_id": "NCT03337503_inc_T35", "arg2_id": "NCT03337503_inc_T40", "normalized": [] }, { "id": "NCT03337503_inc_R19", "type": "Has_value", "arg1_id": "NCT03337503_inc_T44", "arg2_id": "NCT03337503_inc_T45", "normalized": [] }, { "id": "NCT03337503_inc_R20", "type": "Has_value", "arg1_id": "NCT03337503_inc_T42", "arg2_id": "NCT03337503_inc_T43", "normalized": [] }, { "id": "NCT03337503_inc_R21", "type": "Subsumes", "arg1_id": "NCT03337503_inc_T41", "arg2_id": "NCT03337503_inc_T46", "normalized": [] } ]

[ { "id": "NCT03337581_exc_text", "type": "exclusion", "text": [ "allergic to dexmedetomidine, similar active ingredients or excipients\nG-6-PD deficiency\na history of arrhythmia, bronchial and cardiovascular diseases, abnormal liver function and so on\na history of use of alpha 2 receptor agonists or antagonists.\n" ], "offsets": [ [ 0, 248 ] ] } ]

[ { "id": "NCT03337581_exc_T1", "type": "Drug", "text": [ "dexmedetomidine" ], "offsets": [ [ 12, 27 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T2", "type": "Condition", "text": [ "allergic" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T3", "type": "Drug", "text": [ "similar active ingredients" ], "offsets": [ [ 29, 55 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T4", "type": "Drug", "text": [ "excipients" ], "offsets": [ [ 59, 69 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T5", "type": "Scope", "text": [ "dexmedetomidine, similar active ingredients or excipients" ], "offsets": [ [ 12, 69 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T6", "type": "Condition", "text": [ "G-6-PD deficiency" ], "offsets": [ [ 70, 87 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T7", "type": "Condition", "text": [ "arrhythmia" ], "offsets": [ [ 101, 111 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T8", "type": "Observation", "text": [ "history" ], "offsets": [ [ 90, 97 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T9", "type": "Condition", "text": [ "onchial a", "seases," ], "offsets": [ [ 115, 124 ], [ 144, 151 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T10", "type": "Condition", "text": [ "cardiovascular diseases" ], "offsets": [ [ 127, 150 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T11", "type": "Condition", "text": [ "abnormal liver function" ], "offsets": [ [ 152, 175 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T12", "type": "Scope", "text": [ "arrhythmia, bronchial and cardiovascular diseases, abnormal liver function" ], "offsets": [ [ 101, 175 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T13", "type": "Observation", "text": [ "history" ], "offsets": [ [ 188, 195 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T14", "type": "Drug", "text": [ "alpha 2 receptor agonists" ], "offsets": [ [ 206, 231 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T15", "type": "Drug", "text": [ "ha 2 receptor ag", "agonists." ], "offsets": [ [ 209, 225 ], [ 238, 247 ] ], "normalized": [] }, { "id": "NCT03337581_exc_T16", "type": "Scope", "text": [ "alpha 2 receptor agonists or antagonists" ], "offsets": [ [ 206, 246 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03337581_exc_R1", "type": "AND", "arg1_id": "NCT03337581_exc_T5", "arg2_id": "NCT03337581_exc_T2", "normalized": [] }, { "id": "NCT03337581_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03337581_exc_T12", "arg2_id": "NCT03337581_exc_T8", "normalized": [] }, { "id": "NCT03337581_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03337581_exc_T16", "arg2_id": "NCT03337581_exc_T13", "normalized": [] } ]

[ { "id": "NCT03337581_inc_text", "type": "inclusion", "text": [ "selective operation of inguinal hernia repair<U+3001>orthopedics operation or general surgery operation in children\naged 3-9 years\nASA I - II\nenter the operating room by himself without parents\nnormal liver and kidney function\nno history of anesthesia medication allergy.\n" ], "offsets": [ [ 0, 272 ] ] } ]

[ { "id": "NCT03337581_inc_T1", "type": "Procedure", "text": [ "inguinal hernia repair" ], "offsets": [ [ 23, 45 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T2", "type": "Procedure", "text": [ "orthopedics operation" ], "offsets": [ [ 53, 74 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T3", "type": "Procedure", "text": [ "general surgery operation" ], "offsets": [ [ 78, 103 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T4", "type": "Person", "text": [ "children" ], "offsets": [ [ 107, 115 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T5", "type": "Person", "text": [ "aged" ], "offsets": [ [ 116, 120 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T6", "type": "Value", "text": [ "3-9 years" ], "offsets": [ [ 121, 130 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T7", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 131, 134 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T8", "type": "Value", "text": [ "I - II" ], "offsets": [ [ 135, 141 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T10", "type": "Condition", "text": [ "al liv", "ey function\nno" ], "offsets": [ [ 198, 204 ], [ 215, 229 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T11", "type": "Condition", "text": [ "al liver and", "tion\nno" ], "offsets": [ [ 198, 210 ], [ 222, 229 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T12", "type": "Negation", "text": [ "no" ], "offsets": [ [ 227, 229 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T13", "type": "Observation", "text": [ "history" ], "offsets": [ [ 230, 237 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T14", "type": "Drug", "text": [ "anesthesia medication" ], "offsets": [ [ 241, 262 ] ], "normalized": [] }, { "id": "NCT03337581_inc_T15", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 263, 270 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03337581_inc_R1", "type": "Has_value", "arg1_id": "NCT03337581_inc_T5", "arg2_id": "NCT03337581_inc_T6", "normalized": [] }, { "id": "NCT03337581_inc_R2", "type": "Has_value", "arg1_id": "NCT03337581_inc_T7", "arg2_id": "NCT03337581_inc_T8", "normalized": [] }, { "id": "NCT03337581_inc_R3", "type": "AND", "arg1_id": "NCT03337581_inc_T15", "arg2_id": "NCT03337581_inc_T14", "normalized": [] }, { "id": "NCT03337581_inc_R4", "type": "Has_temporal", "arg1_id": "NCT03337581_inc_T15", "arg2_id": "NCT03337581_inc_T13", "normalized": [] }, { "id": "NCT03337581_inc_R5", "type": "Has_negation", "arg1_id": "NCT03337581_inc_T15", "arg2_id": "NCT03337581_inc_T12", "normalized": [] } ]

[ { "id": "NCT03338296_exc_text", "type": "exclusion", "text": [ "Clinically significant new illness within 1 month before randomization that may affect the participant's ability to fulfill the study requirements or significantly confound the assessments\nParticipants who cannot swallow investigational products\nParticipants with T2DM who have hypoglycemia unawareness\nAortic regurgitation mild or greater\nMitral regurgitation moderate or greater\nMitral or aortic valve stenosis greater than mild (ie, aortic stenosis: jet >3.0 meters per second [m/s], mean gradient >25 millimeters of mercury [mmHg], and aortic valve area <1.5 centimeters squared [cm^2]; mitral stenosis: mean gradient >5 mmHg and mitral valve area <1.5 cm^2)\nSystolic pulmonary artery pressure (SPAP) >40 mmHg (and/or tricuspid regurgitation [TR] jet velocity >2.9 m/s) In cases where an actual SPAP value is not measurable due to lack of adequate TR jet, the pulmonary flow acceleration time measured at the right ventricular outflow tract (RVOTAT) will be used to assess eligibility. Participants with a RVOTAT =100 milliseconds (msec) will be excluded, suggesting an elevated mean SPAP; eligibility for the those participants with RVOTAT between 100 and 120 msec will be determined based on combined assessment of the TR jet, septal motion, and right ventricular size.\nLeft ventricular ejection fraction <45%\nIntracardiac mass, tumor, or thrombus\nEvidence of congenital heart disease\nClinically significant pericardial effusion (eg, moderate or larger or with hemodynamic compromise)\nSignificant renal or hepatic disease as evidenced by a serum creatinine greater than 1.5× upper limit of normal (ULN), serum transaminases greater than 3× ULN, or total bilirubin greater than 1.5× ULN in absence of Gilbert's syndrome\nAny suicidal ideation with intent with or without a plan, at the time of or within 6 months of Screening, as indicated by answering \"Yes\" to questions 4 or 5 on the Suicidal Ideation section of the Columbia-Suicide Severity Rating Scale (C-SSRS)\nAny suicidal behavior in the past based on the C-SSRS\nAny history of anorexia or bulimia within 2 years before Screening, Attention Deficit Hyperactivity Disorder, any Diagnostic and Statistical Manual of Mental Disorders, 5th Edition depressive disorder, bipolar disorder, or schizophrenia\nKnown secondary causes (genetic, endocrine, or metabolic) for obesity (eg, Prader-Willi syndrome, Bardet Biedl syndrome, Down's Syndrome, untreated hypothyroidism, Cushing's syndrome, daily systemic corticosteroid exposure for longer than 30 days, history of significant exposure to corticosteroids for chronic illness during the past year; inhaled steroids will be allowed)\nUse of other products intended for weight loss including prescription drugs, over-the-counter (OTC) drugs, and herbal preparations within 1 month before Screening\nselective serotonin reuptake inhibitors\nserotonin norepinephrine reuptake inhibitors\ntricyclic antidepressants\nbupropion\ntriptans\nSt. John's Wort\ntryptophan\nlinezolid\ndextromethorphan in any form (eg, OTC cold medicines)\nlithium\ntramadol\nantipsychotics or other dopamine antagonists\t\nantiseizure medications including valproic acid, zonisamide, topiramate, and lamotrigine\noral steroids (topical and inhaled steroids are acceptable)\nstimulant medications (eg, Ritalin, Concerta, Biphetamine, and Dexedrine)\nbenzodiazepines\nUse of drugs known to increase the risk for cardiac valvulopathy within 6 months before Screening, including but not limited to pergolide, ergotamine, methysergide, and cabergoline\nHistory or evidence of clinically significant disease (eg, malignancy; cardiac, respiratory, gastrointestinal, renal, or psychiatric disease) other than prediabetes (impaired fasting glucose or impaired glucose tolerance), type 2 diabetes treated with oral anti-diabetic agents (excluding sulfonylurea) or non-insulin injectable antidiabetic agents, obstructive sleep apnea, dyslipidemia, and nonalcoholic fatty liver disease\nUse of Belviq XR within 6 months before Screening or hypersensitivity to Belviq XR or any of the excipients\nSignificant change in diet or level of physical activity within 1 month before dosing or change in weight of more than 5 kg within 3 months before Screening\nAny use of a very-low-calorie (<1000 calories/day) weight loss diet within 6 months before Screening\nHistory of alcohol or drug dependence or abuse\nRecreational drug use within 2 years before Screening\nKnown to be human immunodeficiency virus positive\nKnown to have active viral hepatitis (B or C)\nMalignancy within 5 years before Screening\nUnable to attend scheduled visits (eg, lack of transportation) or lack of a caregiver or guardian to supervise study participation\nSpecial needs participants who are unable to comprehend study-related instructions (eg, mild to profound mental retardation [intelligence quotient <70], moderate to severe cognitive developmental delay, pervasive development disorders, autism)\nOngoing epilepsy or other seizure disorder, or use of medications for a seizure disorder within 6 months of screening or any time between screening and randomization\nParticipants with a blood pressure in the 95th percentile or greater for age, sex, and height on 2 separate readings recorded on 2 separate days. Those participants who had uncontrolled hypertension at Screening can be rescreened more than 1 month after initiation or adjustment of antihypertensive therapy 1 time.\nCurrently enrolled in another clinical study or has used any investigational drug or device within 30 days before providing informed consent\nPlanned bariatric surgery during the study or prior bariatric surgical procedures\nNot suitable to participate in the study in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol\nFemale participants who are breastfeeding or pregnant at Screening or Baseline (as documented by a positive beta-human chorionic gonadotropin test). A separate Baseline assessment is required if a negative screening pregnancy test was obtained more than 72 hours before the first dose of study drug.\nHad unprotected sexual intercourse within 30 days before study entry and who do not agree to use a highly effective method of contraception (eg, total abstinence, an intrauterine device, a double-barrier method [such as condom plus diaphragm with spermicide], a contraceptive implant, an oral contraceptive, or have a vasectomized partner with confirmed azoospermia) throughout the entire study period and for 28 days after study drug discontinuation\nAre currently abstinent and do not agree to use a double-barrier method (as described above) or refrain from sexual activity during the study period and for 28 days after study drug discontinuation\nAre using hormonal contraceptives, but are not on a stable dose of the same hormonal contraceptive product for at least 4 weeks before dosing and who do not agree to use the same contraceptive during the study and for 28 days after study drug discontinuation (Note: All female participants will be considered to be of childbearing potential unless they have been sterilized surgically [ie, bilateral tubal ligation, total hysterectomy, or bilateral oophorectomy, all with surgery at least 1 month before dosing]).\n" ], "offsets": [ [ 0, 7277 ] ] } ]

[ { "id": "NCT03338296_exc_T1", "type": "Qualifier", "text": [ "Clinically significant" ], "offsets": [ [ 0, 22 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T2", "type": "Qualifier", "text": [ "new" ], "offsets": [ [ 23, 26 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T3", "type": "Condition", "text": [ "illness" ], "offsets": [ [ 27, 34 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T4", "type": "Temporal", "text": [ "within 1 month before randomization" ], "offsets": [ [ 35, 70 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T5", "type": "Reference_point", "text": [ "randomization" ], "offsets": [ [ 57, 70 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T6", "type": "Observation", "text": [ "may affect the participant's ability to fulfill the study requirements" ], "offsets": [ [ 76, 146 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T7", "type": "Observation", "text": [ "significantly confound the assessments", "may" ], "offsets": [ [ 150, 188 ], [ 76, 79 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T8", "type": "Scope", "text": [ "may affect the participant's ability to fulfill the study requirements or significantly confound the assessments" ], "offsets": [ [ 76, 188 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T9", "type": "Observation", "text": [ "cannot swallow" ], "offsets": [ [ 206, 220 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T10", "type": "Drug", "text": [ "investigational products" ], "offsets": [ [ 221, 245 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T11", "type": "Condition", "text": [ "T2DM" ], "offsets": [ [ 264, 268 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T12", "type": "Condition", "text": [ "hypoglycemia unawareness" ], "offsets": [ [ 278, 302 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T13", "type": "Condition", "text": [ "Aortic regurgitation" ], "offsets": [ [ 303, 323 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T14", "type": "Qualifier", "text": [ "mild or greater" ], "offsets": [ [ 324, 339 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T15", "type": "Condition", "text": [ "Mitral regurgitation" ], "offsets": [ [ 340, 360 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T16", "type": "Qualifier", "text": [ "moderate or greater" ], "offsets": [ [ 361, 380 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T17", "type": "Condition", "text": [ "l or a", " stenosis gre" ], "offsets": [ [ 386, 392 ], [ 403, 416 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T18", "type": "Condition", "text": [ "aortic valve stenosis" ], "offsets": [ [ 391, 412 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T19", "type": "Qualifier", "text": [ "greater than mild" ], "offsets": [ [ 413, 430 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T20", "type": "Scope", "text": [ "Mitral or aortic valve stenosis" ], "offsets": [ [ 381, 412 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T21", "type": "Condition", "text": [ "aortic stenosis" ], "offsets": [ [ 436, 451 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T22", "type": "Measurement", "text": [ "jet" ], "offsets": [ [ 453, 456 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T23", "type": "Value", "text": [ ">3.0 meters per second [m/s]" ], "offsets": [ [ 457, 485 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T24", "type": "Measurement", "text": [ "mean gradient" ], "offsets": [ [ 487, 500 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T25", "type": "Value", "text": [ ">25 millimeters of mercury [mmHg]" ], "offsets": [ [ 501, 534 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T26", "type": "Measurement", "text": [ "aortic valve area" ], "offsets": [ [ 540, 557 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T27", "type": "Value", "text": [ "<1.5 centimeters squared [cm^2]" ], "offsets": [ [ 558, 589 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T28", "type": "Condition", "text": [ "mitral stenosis" ], "offsets": [ [ 591, 606 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T29", "type": "Measurement", "text": [ "mean gradient" ], "offsets": [ [ 608, 621 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T30", "type": "Value", "text": [ ">5 mmHg" ], "offsets": [ [ 622, 629 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T31", "type": "Measurement", "text": [ "mitral valve area" ], "offsets": [ [ 634, 651 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T32", "type": "Value", "text": [ "<1.5 cm^2" ], "offsets": [ [ 652, 661 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T33", "type": "Scope", "text": [ "jet >3.0 meters per second [m/s], mean gradient >25 millimeters of mercury [mmHg], and aortic valve area <1.5 centimeters squared [cm^2]" ], "offsets": [ [ 453, 589 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T34", "type": "Scope", "text": [ "mean gradient >5 mmHg and mitral valve area <1.5 cm^2" ], "offsets": [ [ 608, 661 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T35", "type": "Scope", "text": [ "aortic stenosis: jet >3.0 meters per second [m/s], mean gradient >25 millimeters of mercury [mmHg], and aortic valve area <1.5 centimeters squared [cm^2]; mitral stenosis: mean gradient >5 mmHg and mitral valve area <1.5 cm^2" ], "offsets": [ [ 436, 661 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T36", "type": "Scope", "text": [ "Mitral or aortic valve stenosis greater than mild" ], "offsets": [ [ 381, 430 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T37", "type": "Measurement", "text": [ "Systolic pulmonary artery pressure (SPAP)" ], "offsets": [ [ 663, 704 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T38", "type": "Value", "text": [ ">40 mmHg" ], "offsets": [ [ 705, 713 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T39", "type": "Measurement", "text": [ "tricuspid regurgitation [TR] jet velocity" ], "offsets": [ [ 722, 763 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T40", "type": "Value", "text": [ ">2.9 m/s" ], "offsets": [ [ 764, 772 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T42", "type": "Measurement", "text": [ "RVOTAT" ], "offsets": [ [ 1010, 1016 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T43", "type": "Value", "text": [ "=100 milliseconds (msec)" ], "offsets": [ [ 1017, 1041 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T44", "type": "Measurement", "text": [ "Left ventricular ejection fraction" ], "offsets": [ [ 1276, 1310 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T45", "type": "Value", "text": [ "<45%" ], "offsets": [ [ 1311, 1315 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T46", "type": "Condition", "text": [ "Intracardiac mass" ], "offsets": [ [ 1316, 1333 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T47", "type": "Condition", "text": [ "tumor" ], "offsets": [ [ 1335, 1340 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T48", "type": "Condition", "text": [ "thrombus" ], "offsets": [ [ 1345, 1353 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T50", "type": "Condition", "text": [ "congenital heart disease" ], "offsets": [ [ 1366, 1390 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T51", "type": "Mood", "text": [ "Evidence of" ], "offsets": [ [ 1354, 1365 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T52", "type": "Qualifier", "text": [ "Clinically significant" ], "offsets": [ [ 1391, 1413 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T53", "type": "Condition", "text": [ "pericardial effusion" ], "offsets": [ [ 1414, 1434 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T54", "type": "Qualifier", "text": [ "moderate or larger" ], "offsets": [ [ 1440, 1458 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T55", "type": "Condition", "text": [ "hemodynamic compromise" ], "offsets": [ [ 1467, 1489 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T56", "type": "Scope", "text": [ "moderate or larger or with hemodynamic compromise" ], "offsets": [ [ 1440, 1489 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T57", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 1491, 1502 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T58", "type": "Condition", "text": [ "hepatic disease" ], "offsets": [ [ 1512, 1527 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T59", "type": "Condition", "text": [ "patic", "evidenc" ], "offsets": [ [ 1514, 1519 ], [ 1531, 1538 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T60", "type": "Scope", "text": [ "renal or hepatic disease" ], "offsets": [ [ 1503, 1527 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T61", "type": "Measurement", "text": [ "serum creatinine" ], "offsets": [ [ 1546, 1562 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T62", "type": "Value", "text": [ "greater than 1.5× upper limit of normal (ULN)" ], "offsets": [ [ 1563, 1608 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T63", "type": "Measurement", "text": [ "serum transaminases" ], "offsets": [ [ 1610, 1629 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T64", "type": "Value", "text": [ "greater than 3× ULN" ], "offsets": [ [ 1630, 1649 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T65", "type": "Measurement", "text": [ "total bilirubin" ], "offsets": [ [ 1654, 1669 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T66", "type": "Value", "text": [ "greater than 1.5× ULN" ], "offsets": [ [ 1670, 1691 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T67", "type": "Negation", "text": [ "absence of" ], "offsets": [ [ 1695, 1705 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T68", "type": "Condition", "text": [ "Gilbert's syndrome" ], "offsets": [ [ 1706, 1724 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T69", "type": "Scope", "text": [ "serum creatinine greater than 1.5× upper limit of normal (ULN), serum transaminases greater than 3× ULN, or total bilirubin greater than 1.5× ULN in absence of Gilbert's syndrome" ], "offsets": [ [ 1546, 1724 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T70", "type": "Condition", "text": [ "suicidal ideation" ], "offsets": [ [ 1729, 1746 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T71", "type": "Qualifier", "text": [ "with intent" ], "offsets": [ [ 1747, 1758 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T72", "type": "Qualifier", "text": [ "without a plan" ], "offsets": [ [ 1767, 1781 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T73", "type": "Qualifier", "text": [ "out", "he tim" ], "offsets": [ [ 1771, 1774 ], [ 1787, 1793 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T74", "type": "Scope", "text": [ "with or without a plan" ], "offsets": [ [ 1759, 1781 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T75", "type": "Temporal", "text": [ "of or within 6", "s indicat" ], "offsets": [ [ 1795, 1809 ], [ 1832, 1841 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T76", "type": "Temporal", "text": [ "within 6 months of Screening" ], "offsets": [ [ 1801, 1829 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T77", "type": "Scope", "text": [ "at the time of or within 6 months of Screening" ], "offsets": [ [ 1783, 1829 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T78", "type": "Procedure", "text": [ "Suicidal Ideation section of the Columbia-Suicide Severity Rating Scale (C-SSRS)" ], "offsets": [ [ 1890, 1970 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T79", "type": "Measurement", "text": [ "questions 4" ], "offsets": [ [ 1866, 1877 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T80", "type": "Measurement", "text": [ "or 5 on t", "c" ], "offsets": [ [ 1878, 1887 ], [ 1893, 1894 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T81", "type": "Value", "text": [ "Yes" ], "offsets": [ [ 1858, 1861 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T82", "type": "Scope", "text": [ "questions 4 or 5" ], "offsets": [ [ 1866, 1882 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T83", "type": "Condition", "text": [ "suicidal behavior" ], "offsets": [ [ 1975, 1992 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T84", "type": "Temporal", "text": [ "in the past" ], "offsets": [ [ 1993, 2004 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T85", "type": "Procedure", "text": [ "C-SSRS" ], "offsets": [ [ 2018, 2024 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T86", "type": "Observation", "text": [ "history" ], "offsets": [ [ 2029, 2036 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T87", "type": "Condition", "text": [ "anorexia" ], "offsets": [ [ 2040, 2048 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T88", "type": "Condition", "text": [ "bulimia" ], "offsets": [ [ 2052, 2059 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T89", "type": "Temporal", "text": [ "within 2 years before Screening" ], "offsets": [ [ 2060, 2091 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T90", "type": "Reference_point", "text": [ "Screening" ], "offsets": [ [ 2082, 2091 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T91", "type": "Scope", "text": [ "anorexia or bulimia" ], "offsets": [ [ 2040, 2059 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T92", "type": "Condition", "text": [ "Attention Deficit Hyperactivity Disorder" ], "offsets": [ [ 2093, 2133 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T93", "type": "Qualifier", "text": [ "Diagnostic and Statistical Manual of Mental Disorders, 5th Edition" ], "offsets": [ [ 2139, 2205 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T94", "type": "Condition", "text": [ "depressive disorder" ], "offsets": [ [ 2206, 2225 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T95", "type": "Condition", "text": [ "bipolar disorder" ], "offsets": [ [ 2227, 2243 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T96", "type": "Condition", "text": [ "schizophrenia" ], "offsets": [ [ 2248, 2261 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T97", "type": "Scope", "text": [ "depressive disorder, bipolar disorder, or schizophrenia" ], "offsets": [ [ 2206, 2261 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T98", "type": "Condition", "text": [ "s (genetic, endo", ", Prader-Wi" ], "offsets": [ [ 2283, 2299 ], [ 2335, 2346 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T99", "type": "Qualifier", "text": [ "genetic" ], "offsets": [ [ 2286, 2293 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T100", "type": "Qualifier", "text": [ "endocrine" ], "offsets": [ [ 2295, 2304 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T101", "type": "Qualifier", "text": [ "metabolic" ], "offsets": [ [ 2309, 2318 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T102", "type": "Scope", "text": [ "genetic, endocrine, or metabolic" ], "offsets": [ [ 2286, 2318 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T103", "type": "Condition", "text": [ "Prader-Willi syndrome" ], "offsets": [ [ 2337, 2358 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T104", "type": "Condition", "text": [ "Bardet Biedl syndrome" ], "offsets": [ [ 2360, 2381 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T105", "type": "Condition", "text": [ "Down's Syndrome" ], "offsets": [ [ 2383, 2398 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T106", "type": "Condition", "text": [ "untreated hypothyroidism" ], "offsets": [ [ 2400, 2424 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T107", "type": "Condition", "text": [ "Cushing's syndrome" ], "offsets": [ [ 2426, 2444 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T108", "type": "Multiplier", "text": [ "daily" ], "offsets": [ [ 2446, 2451 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T109", "type": "Drug", "text": [ "systemic corticosteroid" ], "offsets": [ [ 2452, 2475 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T110", "type": "Temporal", "text": [ "for longer than 30 days" ], "offsets": [ [ 2485, 2508 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T111", "type": "Observation", "text": [ "history" ], "offsets": [ [ 2510, 2517 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T112", "type": "Qualifier", "text": [ "significant exposure" ], "offsets": [ [ 2521, 2541 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T113", "type": "Drug", "text": [ "corticosteroids" ], "offsets": [ [ 2545, 2560 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T114", "type": "Condition", "text": [ "chronic illness" ], "offsets": [ [ 2565, 2580 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T115", "type": "Temporal", "text": [ "during the past year" ], "offsets": [ [ 2581, 2601 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T117", "type": "Scope", "text": [ "Prader-Willi syndrome, Bardet Biedl syndrome, Down's Syndrome, untreated hypothyroidism, Cushing's syndrome, daily systemic corticosteroid exposure for longer than 30 days, history of significant exposure to corticosteroids for chronic illness during the past year; inhaled steroids will be allowed" ], "offsets": [ [ 2337, 2635 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T118", "type": "Scope", "text": [ "secondary causes (genetic, endocrine, or metabolic) for obesity" ], "offsets": [ [ 2268, 2331 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T119", "type": "Drug", "text": [ "products intended for weight loss" ], "offsets": [ [ 2650, 2683 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T120", "type": "Qualifier", "text": [ "prescription" ], "offsets": [ [ 2694, 2706 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T121", "type": "Qualifier", "text": [ "over-the-counter (OTC)" ], "offsets": [ [ 2714, 2736 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T122", "type": "Qualifier", "text": [ "herbal" ], "offsets": [ [ 2748, 2754 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T123", "type": "Temporal", "text": [ "within 1 month before Screening" ], "offsets": [ [ 2768, 2799 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T124", "type": "Reference_point", "text": [ "Screening" ], "offsets": [ [ 2790, 2799 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T125", "type": "Scope", "text": [ "prescription drugs, over-the-counter (OTC) drugs, and herbal" ], "offsets": [ [ 2694, 2754 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T126", "type": "Drug", "text": [ "selective serotonin reuptake inhibitors" ], "offsets": [ [ 2800, 2839 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T127", "type": "Drug", "text": [ "serotonin norepinephrine reuptake inhibitors" ], "offsets": [ [ 2840, 2884 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T128", "type": "Drug", "text": [ "tricyclic antidepressants" ], "offsets": [ [ 2885, 2910 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T129", "type": "Drug", "text": [ "bupropion" ], "offsets": [ [ 2911, 2920 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T130", "type": "Drug", "text": [ "triptans" ], "offsets": [ [ 2921, 2929 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T131", "type": "Drug", "text": [ "St. John's Wort" ], "offsets": [ [ 2930, 2945 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T132", "type": "Drug", "text": [ "tryptophan" ], "offsets": [ [ 2946, 2956 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T133", "type": "Drug", "text": [ "linezolid" ], "offsets": [ [ 2957, 2966 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T134", "type": "Drug", "text": [ "dextromethorphan" ], "offsets": [ [ 2967, 2983 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T135", "type": "Qualifier", "text": [ "any form" ], "offsets": [ [ 2987, 2995 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T136", "type": "Drug", "text": [ "lithium" ], "offsets": [ [ 3021, 3028 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T137", "type": "Drug", "text": [ "tramadol" ], "offsets": [ [ 3029, 3037 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T138", "type": "Drug", "text": [ "antipsychotics" ], "offsets": [ [ 3038, 3052 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T139", "type": "Drug", "text": [ "dopamine antagonists" ], "offsets": [ [ 3062, 3082 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T140", "type": "Drug", "text": [ "antiseizure medications" ], "offsets": [ [ 3084, 3107 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T141", "type": "Drug", "text": [ "valproic acid" ], "offsets": [ [ 3118, 3131 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T142", "type": "Drug", "text": [ "zonisamide" ], "offsets": [ [ 3133, 3143 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T143", "type": "Drug", "text": [ "topiramate" ], "offsets": [ [ 3145, 3155 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T144", "type": "Drug", "text": [ "lamotrigine" ], "offsets": [ [ 3161, 3172 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T145", "type": "Scope", "text": [ "valproic acid, zonisamide, topiramate, and lamotrigine" ], "offsets": [ [ 3118, 3172 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T146", "type": "Drug", "text": [ "oral steroids" ], "offsets": [ [ 3173, 3186 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T147", "type": "Drug", "text": [ "inhaled steroids" ], "offsets": [ [ 3200, 3216 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T148", "type": "Drug", "text": [ "re acce", "lant med" ], "offsets": [ [ 3218, 3225 ], [ 3238, 3246 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T149", "type": "Negation", "text": [ "acceptable" ], "offsets": [ [ 3221, 3231 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T150", "type": "Scope", "text": [ "topical and inhaled steroids" ], "offsets": [ [ 3188, 3216 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T151", "type": "Drug", "text": [ "stimulant medications" ], "offsets": [ [ 3233, 3254 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T152", "type": "Drug", "text": [ "Ritalin" ], "offsets": [ [ 3260, 3267 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T153", "type": "Drug", "text": [ "Concerta" ], "offsets": [ [ 3269, 3277 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T154", "type": "Drug", "text": [ "Biphetamine" ], "offsets": [ [ 3279, 3290 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T155", "type": "Drug", "text": [ "Dexedrine" ], "offsets": [ [ 3296, 3305 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T156", "type": "Scope", "text": [ "Ritalin, Concerta, Biphetamine, and Dexedrine" ], "offsets": [ [ 3260, 3305 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T157", "type": "Drug", "text": [ "benzodiazepines" ], "offsets": [ [ 3307, 3322 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T158", "type": "Drug", "text": [ "drugs" ], "offsets": [ [ 3330, 3335 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T159", "type": "Condition", "text": [ "cardiac valvulopathy" ], "offsets": [ [ 3367, 3387 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T160", "type": "Temporal", "text": [ "within 6 months before Screening" ], "offsets": [ [ 3388, 3420 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T161", "type": "Drug", "text": [ "pergolide" ], "offsets": [ [ 3451, 3460 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T162", "type": "Drug", "text": [ "ergotamine" ], "offsets": [ [ 3462, 3472 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T163", "type": "Drug", "text": [ "methysergide" ], "offsets": [ [ 3474, 3486 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T164", "type": "Drug", "text": [ "cabergoline" ], "offsets": [ [ 3492, 3503 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T165", "type": "Scope", "text": [ "pergolide, ergotamine, methysergide, and cabergoline" ], "offsets": [ [ 3451, 3503 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T166", "type": "Qualifier", "text": [ "known to increase the risk for cardiac valvulopathy" ], "offsets": [ [ 3336, 3387 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T167", "type": "Scope", "text": [ "drugs known to increase the risk for cardiac valvulopathy" ], "offsets": [ [ 3330, 3387 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T168", "type": "Observation", "text": [ "History" ], "offsets": [ [ 3504, 3511 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T169", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 3527, 3549 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T170", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 3550, 3557 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T171", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 3563, 3573 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T172", "type": "Qualifier", "text": [ "cardiac" ], "offsets": [ [ 3575, 3582 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T173", "type": "Qualifier", "text": [ "respiratory" ], "offsets": [ [ 3584, 3595 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T174", "type": "Qualifier", "text": [ "gastrointestinal" ], "offsets": [ [ 3597, 3613 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T175", "type": "Qualifier", "text": [ "renal" ], "offsets": [ [ 3615, 3620 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T176", "type": "Qualifier", "text": [ "psychiatric" ], "offsets": [ [ 3625, 3636 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T177", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 3637, 3644 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T178", "type": "Scope", "text": [ "cardiac, respiratory, gastrointestinal, renal, or psychiatric" ], "offsets": [ [ 3575, 3636 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T179", "type": "Scope", "text": [ "cardiac, respiratory, gastrointestinal, renal, or psychiatric disease" ], "offsets": [ [ 3575, 3644 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T180", "type": "Scope", "text": [ "History or evidence of clinically significant" ], "offsets": [ [ 3504, 3549 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T181", "type": "Scope", "text": [ "History or evidence of clinically significant disease" ], "offsets": [ [ 3504, 3557 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T182", "type": "Scope", "text": [ "malignancy; cardiac, respiratory, gastrointestinal, renal, or psychiatric disease" ], "offsets": [ [ 3563, 3644 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T183", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 3646, 3656 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T184", "type": "Condition", "text": [ "prediabetes" ], "offsets": [ [ 3657, 3668 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T185", "type": "Value", "text": [ "impaired" ], "offsets": [ [ 3698, 3706 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T186", "type": "Measurement", "text": [ "fasting glucose" ], "offsets": [ [ 3679, 3694 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T187", "type": "Condition", "text": [ "impaired glucose tolerance" ], "offsets": [ [ 3698, 3724 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T188", "type": "Condition", "text": [ "impaired fasting glucose" ], "offsets": [ [ 3670, 3694 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T189", "type": "Condition", "text": [ "type 2 diabetes" ], "offsets": [ [ 3727, 3742 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T190", "type": "Drug", "text": [ "oral anti-diabetic agents" ], "offsets": [ [ 3756, 3781 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T191", "type": "Drug", "text": [ "sulfonylurea" ], "offsets": [ [ 3793, 3805 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T192", "type": "Negation", "text": [ "excluding" ], "offsets": [ [ 3783, 3792 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T193", "type": "Scope", "text": [ "excluding sulfonylurea" ], "offsets": [ [ 3783, 3805 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T194", "type": "Qualifier", "text": [ "non-insulin" ], "offsets": [ [ 3810, 3821 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T195", "type": "Qualifier", "text": [ "injectable" ], "offsets": [ [ 3822, 3832 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T196", "type": "Drug", "text": [ "antidiabetic agents" ], "offsets": [ [ 3833, 3852 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T197", "type": "Condition", "text": [ "obstructive sleep apnea" ], "offsets": [ [ 3854, 3877 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T198", "type": "Condition", "text": [ "dyslipidemia" 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"id": "NCT03338296_exc_T205", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 3983, 3999 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T206", "type": "Drug", "text": [ "Belviq XR" ], "offsets": [ [ 4003, 4012 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T207", "type": "Qualifier", "text": [ "or any of the excipients" ], "offsets": [ [ 4013, 4037 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T208", "type": "Observation", "text": [ "change in diet" ], "offsets": [ [ 4050, 4064 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T209", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 4038, 4049 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T210", "type": "Observation", "text": [ "activity", "month before dosing or cha" ], "offsets": [ [ 4086, 4094 ], [ 4104, 4130 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T211", "type": "Temporal", "text": [ "within 1 month before dosing" ], "offsets": [ [ 4095, 4123 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T212", "type": "Reference_point", "text": [ "dosing" ], "offsets": [ [ 4117, 4123 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T213", "type": "Scope", "text": [ "change in diet or level of physical activity" ], "offsets": [ [ 4050, 4094 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T214", "type": "Observation", "text": [ "change in weight" ], "offsets": [ [ 4127, 4143 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T215", "type": "Value", "text": [ "more than 5 kg" ], "offsets": [ [ 4147, 4161 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T216", "type": "Temporal", "text": [ "within 3 months before Screening" ], "offsets": [ [ 4162, 4194 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T217", "type": "Reference_point", "text": [ "Screening" ], "offsets": [ [ 4185, 4194 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T218", "type": "Observation", "text": [ " weight loss di", "re Screening\nHis" ], "offsets": [ [ 4245, 4260 ], [ 4283, 4299 ] ], 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}, { "id": "NCT03338296_exc_T226", "type": "Condition", "text": [ "creatio", "use within" ], "offsets": [ [ 4345, 4352 ], [ 4361, 4371 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T227", "type": "Scope", "text": [ "alcohol or drug dependence or abuse" ], "offsets": [ [ 4307, 4342 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T228", "type": "Observation", "text": [ "Recreational drug use" ], "offsets": [ [ 4343, 4364 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T229", "type": "Temporal", "text": [ "within 2 years before Screening" ], "offsets": [ [ 4365, 4396 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T230", "type": "Reference_point", "text": [ "Screening" ], "offsets": [ [ 4387, 4396 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T231", "type": "Condition", "text": [ "human immunodeficiency virus positive" ], "offsets": [ [ 4409, 4446 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T232", "type": "Measurement", "text": [ "human immunodeficiency virus" ], "offsets": [ [ 4409, 4437 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T233", "type": "Value", "text": [ "positive" ], "offsets": [ [ 4438, 4446 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T234", "type": "Condition", "text": [ "viral hepatitis" ], "offsets": [ [ 4468, 4483 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T235", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 4461, 4467 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T236", "type": "Qualifier", "text": [ "B" ], "offsets": [ [ 4485, 4486 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T237", "type": "Qualifier", "text": [ "C" ], "offsets": [ [ 4490, 4491 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T238", "type": "Scope", "text": [ "B or C" ], "offsets": [ [ 4485, 4491 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T239", "type": "Condition", "text": [ "Malignancy" ], "offsets": [ [ 4493, 4503 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T240", "type": "Temporal", "text": [ "within 5 years before Screening" ], "offsets": [ [ 4504, 4535 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T241", "type": "Reference_point", "text": [ "Screening" ], "offsets": [ [ 4526, 4535 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T242", "type": "Observation", "text": [ "Unable to attend scheduled visits" ], "offsets": [ [ 4536, 4569 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T243", "type": "Observation", "text": [ "lack of transportation" ], "offsets": [ [ 4575, 4597 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T244", "type": "Observation", "text": [ "lack of a caregiver" ], "offsets": [ [ 4602, 4621 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T245", "type": "Observation", "text": [ "e study", "pecial n" ], "offsets": [ [ 4645, 4652 ], [ 4668, 4676 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T246", "type": "Observation", "text": [ "Special needs" ], "offsets": [ [ 4667, 4680 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T247", "type": "Observation", "text": [ "ons (eg, mild to pro", "tardation [i" ], "offsets": [ [ 4746, 4766 ], [ 4781, 4793 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T248", "type": "Qualifier", "text": [ "study-related" ], "offsets": [ [ 4723, 4736 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T249", "type": "Qualifier", "text": [ "mild to profound" ], "offsets": [ [ 4755, 4771 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T250", "type": "Condition", "text": [ "mental retardation" ], "offsets": [ [ 4772, 4790 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T251", "type": "Measurement", "text": [ "intelligence quotient" ], "offsets": [ [ 4792, 4813 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T252", "type": "Value", "text": [ "<70" ], "offsets": [ [ 4814, 4817 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T253", "type": "Qualifier", "text": [ "moderate to severe" ], "offsets": [ [ 4820, 4838 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T254", "type": "Condition", "text": [ "cognitive developmental delay" ], "offsets": [ [ 4839, 4868 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T255", "type": "Condition", "text": [ "pervasive development disorders" ], "offsets": [ [ 4870, 4901 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T256", "type": "Condition", "text": [ "autism" ], "offsets": [ [ 4903, 4909 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T257", "type": "Scope", "text": [ "intelligence quotient <70" ], "offsets": [ [ 4792, 4817 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T258", "type": "Scope", "text": [ "mild to profound mental retardation" ], "offsets": [ [ 4755, 4790 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T259", "type": "Scope", "text": [ "mild to profound mental retardation [intelligence quotient <70], moderate to severe cognitive developmental delay, pervasive development disorders, autism" ], "offsets": [ [ 4755, 4909 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T260", "type": "Scope", "text": [ "unable to comprehend study-related instructions" ], "offsets": [ [ 4702, 4749 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T261", "type": "Temporal", "text": [ "Ongoing" ], "offsets": [ [ 4911, 4918 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T262", "type": "Condition", "text": [ "epilepsy" ], "offsets": [ [ 4919, 4927 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T263", "type": "Qualifier", "text": [ "Ongoing" ], "offsets": [ [ 4911, 4918 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T264", "type": "Condition", "text": [ "seizure disorder" ], "offsets": [ [ 4983, 4999 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T265", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 4931, 4936 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T266", "type": "Drug", "text": [ "medications" ], "offsets": [ [ 4965, 4976 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T267", "type": "Condition", "text": [ "seizure disorder" ], "offsets": [ [ 4983, 4999 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T268", "type": "Temporal", "text": [ "within 6 months of screening" ], "offsets": [ [ 5000, 5028 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T269", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 5049, 5058 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T270", "type": "Temporal", "text": [ "any time between screening and randomization" ], "offsets": [ [ 5032, 5076 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T271", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 5049, 5058 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T272", "type": "Reference_point", "text": [ "randomization" ], "offsets": [ [ 5063, 5076 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T273", "type": "Scope", "text": [ "within 6 months of screening or any time between screening and randomization" ], "offsets": [ [ 5000, 5076 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T274", "type": "Measurement", "text": [ "blood pressure" ], "offsets": [ [ 5097, 5111 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T275", "type": "Value", "text": [ "95th percentile or greater" ], "offsets": [ [ 5119, 5145 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T276", "type": "Qualifier", "text": [ "for age" ], "offsets": [ [ 5146, 5153 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T277", "type": "Qualifier", "text": [ "s r", "d o" ], "offsets": [ [ 5192, 5195 ], [ 5201, 5204 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T278", "type": "Qualifier", "text": [ "s r", "parate" ], "offsets": [ [ 5192, 5195 ], [ 5210, 5216 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T279", "type": "Multiplier", "text": [ "2 separate readings" ], "offsets": [ [ 5174, 5193 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T280", "type": "Qualifier", "text": [ "2 separate days" ], "offsets": [ [ 5206, 5221 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T282", "type": "Observation", "text": [ "any investi", "drug or device" ], "offsets": [ [ 5449, 5460 ], [ 5469, 5483 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T283", "type": "Qualifier", "text": [ "another" ], "offsets": [ [ 5414, 5421 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T284", "type": "Temporal", "text": [ "Currently" ], "offsets": [ [ 5392, 5401 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T285", "type": "Drug", "text": [ "investigational drug" ], "offsets": [ [ 5453, 5473 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T286", "type": "Temporal", "text": [ "within 30 days before providing informed consent" ], "offsets": [ [ 5484, 5532 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T287", "type": "Device", "text": [ "device" ], "offsets": [ [ 5477, 5483 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T288", "type": "Scope", "text": [ "investigational drug or device" ], "offsets": [ [ 5453, 5483 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T289", "type": "Mood", "text": [ "Planned" ], "offsets": [ [ 5533, 5540 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T290", "type": "Procedure", "text": [ "bariatric surgery" ], "offsets": [ [ 5541, 5558 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T291", "type": "Temporal", "text": [ "during the study" ], "offsets": [ [ 5559, 5575 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T292", "type": "Reference_point", "text": [ "the study" ], "offsets": [ [ 5646, 5655 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T293", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 5579, 5584 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T294", "type": "Procedure", "text": [ "bariatric surgical procedures" ], "offsets": [ [ 5585, 5614 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T296", "type": "Person", "text": [ "Female" ], "offsets": [ [ 5814, 5820 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T297", "type": "Observation", "text": [ "breastfeeding" ], "offsets": [ [ 5842, 5855 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T298", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 5859, 5867 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T299", "type": "Temporal", "text": [ "at Screening" ], "offsets": [ [ 5868, 5880 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T300", "type": "Temporal", "text": [ "iv", "horionic" ], "offsets": [ [ 5918, 5920 ], [ 5934, 5942 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T301", "type": "Scope", "text": [ "breastfeeding or pregnant" ], "offsets": [ [ 5842, 5867 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T302", "type": "Scope", "text": [ "at Screening or Baseline" ], "offsets": [ [ 5868, 5892 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T303", "type": "Measurement", "text": [ "beta-human chorionic gonadotropin test" ], "offsets": [ [ 5922, 5960 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T304", "type": "Value", "text": [ "positive" ], "offsets": [ [ 5913, 5921 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T305", "type": "Value", "text": [ "negative" ], "offsets": [ [ 6011, 6019 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T306", "type": "Measurement", "text": [ "screening pregnancy test" ], "offsets": [ [ 6020, 6044 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T307", "type": "Qualifier", "text": [ "separate" ], "offsets": [ [ 5965, 5973 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T308", "type": "Procedure", "text": [ "Baseline assessment" ], "offsets": [ [ 5974, 5993 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T309", "type": "Temporal", "text": [ "more than 72 hours before the first dose of study drug" ], "offsets": [ [ 6058, 6112 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T310", "type": "Reference_point", "text": [ "the first dose of study drug" ], "offsets": [ [ 6084, 6112 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T311", "type": "Scope", "text": [ "negative screening pregnancy test was obtained more than 72 hours before the first dose of study drug" ], "offsets": [ [ 6011, 6112 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T312", "type": "Scope", "text": [ "positive beta-human chorionic gonadotropin test" ], "offsets": [ [ 5913, 5960 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T313", "type": "Scope", "text": [ "separate Baseline assessment is required if a negative screening pregnancy test was obtained more than 72 hours before the first dose of study drug" ], "offsets": [ [ 5965, 6112 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T314", "type": "Condition", "text": [ "unprotected sexual intercourse" ], "offsets": [ [ 6118, 6148 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T315", "type": "Temporal", "text": [ "within 30 days before study entry" ], "offsets": [ [ 6149, 6182 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T316", "type": "Reference_point", "text": [ "study entry" ], "offsets": [ [ 6171, 6182 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T317", "type": "Observation", "text": [ "do not agree" ], "offsets": [ [ 6191, 6203 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T318", "type": "Qualifier", "text": [ "highly effective" ], "offsets": [ [ 6213, 6229 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T319", "type": "Observation", "text": [ "method of contraception" ], "offsets": [ [ 6230, 6253 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T320", "type": "Measurement", "text": [ "abstinence" ], "offsets": [ [ 6265, 6275 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T321", "type": "Value", "text": [ "total" ], "offsets": [ [ 6259, 6264 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T322", "type": "Device", "text": [ "intrauterine device" ], "offsets": [ [ 6280, 6299 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T323", "type": "Observation", "text": [ "double-barrier method" ], "offsets": [ [ 6303, 6324 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T324", "type": "Device", "text": [ "condom" ], "offsets": [ [ 6334, 6340 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T325", "type": "Device", "text": [ "diaphragm with spermicide" ], "offsets": [ [ 6346, 6371 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T326", "type": "Scope", "text": [ "condom plus diaphragm with spermicide" ], "offsets": [ [ 6334, 6371 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T327", "type": "Device", "text": [ "contraceptive implant" ], "offsets": [ [ 6376, 6397 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T328", "type": "Drug", "text": [ "oral contraceptive" ], "offsets": [ [ 6402, 6420 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T329", "type": "Procedure", "text": [ "vasectomized" ], "offsets": [ [ 6432, 6444 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T330", "type": "Person", "text": [ "partner" ], "offsets": [ [ 6445, 6452 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T331", "type": "Condition", "text": [ "azoospermia" ], "offsets": [ [ 6468, 6479 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T332", "type": "Scope", "text": [ "condom plus diaphragm with spermicide], a contraceptive implant, an oral contraceptive, or have a vasectomized partner with confirmed azoospermia" ], "offsets": [ [ 6334, 6479 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T333", "type": "Temporal", "text": [ "throughout the entire study period" ], "offsets": [ [ 6481, 6515 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T334", "type": "Temporal", "text": [ "for 28 days after study drug discontinuation" ], "offsets": [ [ 6520, 6564 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T335", "type": "Reference_point", "text": [ "the entire study period" ], "offsets": [ [ 6492, 6515 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T336", "type": "Reference_point", "text": [ "study drug discontinuation" ], "offsets": [ [ 6538, 6564 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T337", "type": "Drug", "text": [ "study drug" ], "offsets": [ [ 6538, 6548 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T338", "type": "Scope", "text": [ "total abstinence, an intrauterine device, a double-barrier method [such as condom plus diaphragm with spermicide], a contraceptive implant, an oral contraceptive, or have a vasectomized partner with confirmed azoospermia" ], "offsets": [ [ 6259, 6479 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T339", "type": "Scope", "text": [ "highly effective method of contraception" ], "offsets": [ [ 6213, 6253 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T340", "type": "Condition", "text": [ "abstinent" ], "offsets": [ [ 6579, 6588 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T341", "type": "Temporal", "text": [ "currently" ], "offsets": [ [ 6569, 6578 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T342", "type": "Observation", "text": [ "double-barrier method" ], "offsets": [ [ 6615, 6636 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T343", "type": "Observation", "text": [ "do not agree" ], "offsets": [ [ 6593, 6605 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T344", "type": "Observation", "text": [ "sexual activity" ], "offsets": [ [ 6674, 6689 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T345", "type": "Negation", "text": [ "refrain" ], "offsets": [ [ 6661, 6668 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T346", "type": "Temporal", "text": [ "during the study period" ], "offsets": [ [ 6690, 6713 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T347", "type": "Temporal", "text": [ "for 28 days after study drug discontinuation" ], "offsets": [ [ 6718, 6762 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T348", "type": "Reference_point", "text": [ "the study period" ], "offsets": [ [ 6697, 6713 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T349", "type": "Reference_point", "text": [ "study drug discontinuation" ], "offsets": [ [ 6736, 6762 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T350", "type": "Drug", "text": [ "study drug" ], "offsets": [ [ 6736, 6746 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T351", "type": "Scope", "text": [ "during the study period and for 28 days after study drug discontinuation" ], "offsets": [ [ 6690, 6762 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T352", "type": "Scope", "text": [ "double-barrier method (as described above) or refrain from sexual activity" ], "offsets": [ [ 6615, 6689 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T353", "type": "Drug", "text": [ "hormonal contraceptives" ], "offsets": [ [ 6773, 6796 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T354", "type": "Negation", "text": [ "not" ], "offsets": [ [ 6806, 6809 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T355", "type": "Qualifier", "text": [ "stable dose" ], "offsets": [ [ 6815, 6826 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T356", "type": "Drug", "text": [ "hormonal contraceptive" ], "offsets": [ [ 6839, 6861 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T357", "type": "Temporal", "text": [ "for at least 4 weeks before dosing" ], "offsets": [ [ 6870, 6904 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T358", "type": "Drug", "text": [ "contraceptive" ], "offsets": [ [ 6942, 6955 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T359", "type": "Temporal", "text": [ "during the study" ], "offsets": [ [ 6956, 6972 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T360", "type": "Temporal", "text": [ "for 28 days after study drug discontinuation" ], "offsets": [ [ 6977, 7021 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T361", "type": "Reference_point", "text": [ "study drug discontinuation" ], "offsets": [ [ 6995, 7021 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T362", "type": "Observation", "text": [ "do not agree" ], "offsets": [ [ 6913, 6925 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T363", "type": "Qualifier", "text": [ "the same" ], "offsets": [ [ 6933, 6941 ] ], "normalized": [] }, { "id": "NCT03338296_exc_T364", "type": "Qualifier", "text": [ "the same" ], "offsets": [ [ 6933, 6941 ] ], "normalized": [] } ]

[]

[]

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"NCT03338296_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03338296_exc_T15", "arg2_id": "NCT03338296_exc_T16", "normalized": [] }, { "id": "NCT03338296_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03338296_exc_T20", "arg2_id": "NCT03338296_exc_T19", "normalized": [] }, { "id": "NCT03338296_exc_R10", "type": "Has_value", "arg1_id": "NCT03338296_exc_T22", "arg2_id": "NCT03338296_exc_T23", "normalized": [] }, { "id": "NCT03338296_exc_R11", "type": "Has_value", "arg1_id": "NCT03338296_exc_T24", "arg2_id": "NCT03338296_exc_T25", "normalized": [] }, { "id": "NCT03338296_exc_R12", "type": "Has_value", "arg1_id": "NCT03338296_exc_T26", "arg2_id": "NCT03338296_exc_T27", "normalized": [] }, { "id": "NCT03338296_exc_R13", "type": "Has_value", "arg1_id": "NCT03338296_exc_T29", "arg2_id": "NCT03338296_exc_T30", "normalized": [] }, { "id": "NCT03338296_exc_R14", "type": "Has_value", "arg1_id": "NCT03338296_exc_T31", "arg2_id": "NCT03338296_exc_T32", "normalized": [] }, { "id": "NCT03338296_exc_R15", "type": "Has_scope", "arg1_id": "NCT03338296_exc_T21", "arg2_id": "NCT03338296_exc_T33", "normalized": [] }, { "id": "NCT03338296_exc_R16", "type": "Has_scope", "arg1_id": "NCT03338296_exc_T28", "arg2_id": "NCT03338296_exc_T34", "normalized": [] }, { "id": "NCT03338296_exc_R17", "type": "Has_scope", "arg1_id": "NCT03338296_exc_T36", "arg2_id": "NCT03338296_exc_T35", "normalized": [] }, { "id": "NCT03338296_exc_R18", "type": "Has_value", "arg1_id": "NCT03338296_exc_T37", "arg2_id": "NCT03338296_exc_T38", "normalized": [] }, { "id": "NCT03338296_exc_R19", "type": "Has_value", "arg1_id": "NCT03338296_exc_T39", "arg2_id": "NCT03338296_exc_T40", "normalized": [] }, { "id": "NCT03338296_exc_R20", "type": "Has_value", "arg1_id": "NCT03338296_exc_T42", "arg2_id": "NCT03338296_exc_T43", "normalized": [] }, { "id": "NCT03338296_exc_R21", "type": "Has_value", "arg1_id": "NCT03338296_exc_T44", "arg2_id": "NCT03338296_exc_T45", "normalized": [] }, { "id": "NCT03338296_exc_R22", "type": "Has_mood", "arg1_id": "NCT03338296_exc_T50", "arg2_id": "NCT03338296_exc_T51", "normalized": [] }, { "id": "NCT03338296_exc_R23", "type": "Has_qualifier", "arg1_id": "NCT03338296_exc_T53", "arg2_id": "NCT03338296_exc_T52", "normalized": [] }, { "id": "NCT03338296_exc_R24", "type": "Subsumes", "arg1_id": "NCT03338296_exc_T52", "arg2_id": "NCT03338296_exc_T56", "normalized": [] }, { "id": "NCT03338296_exc_R25", "type": "Has_qualifier", "arg1_id": "NCT03338296_exc_T60", "arg2_id": "NCT03338296_exc_T57", "normalized": [] }, { "id": "NCT03338296_exc_R26", "type": "Has_value", "arg1_id": "NCT03338296_exc_T61", "arg2_id": "NCT03338296_exc_T62", "normalized": [] }, { "id": "NCT03338296_exc_R27", "type": "Has_value", "arg1_id": "NCT03338296_exc_T63", "arg2_id": "NCT03338296_exc_T64", "normalized": [] }, { "id": "NCT03338296_exc_R28", "type": "Has_negation", "arg1_id": "NCT03338296_exc_T68", "arg2_id": "NCT03338296_exc_T67", "normalized": [] }, { "id": "NCT03338296_exc_R29", "type": "Has_value", "arg1_id": "NCT03338296_exc_T65", "arg2_id": "NCT03338296_exc_T66", "normalized": [] }, { "id": "NCT03338296_exc_R30", "type": "AND", "arg1_id": "NCT03338296_exc_T65", "arg2_id": "NCT03338296_exc_T68", "normalized": [] }, { "id": "NCT03338296_exc_R31", "type": "Has_scope", "arg1_id": "NCT03338296_exc_T60", "arg2_id": "NCT03338296_exc_T69", "normalized": [] }, { "id": "NCT03338296_exc_R32", "type": "Has_qualifier", "arg1_id": "NCT03338296_exc_T70", "arg2_id": "NCT03338296_exc_T71", "normalized": [] }, { "id": "NCT03338296_exc_R33", "type": "Has_scope", "arg1_id": "NCT03338296_exc_T70", "arg2_id": "NCT03338296_exc_T74", "normalized": [] }, { "id": "NCT03338296_exc_R34", "type": "Has_scope", "arg1_id": "NCT03338296_exc_T70", "arg2_id": "NCT03338296_exc_T77", "normalized": [] }, { "id": "NCT03338296_exc_R35", "type": "Has_value", "arg1_id": "NCT03338296_exc_T82", "arg2_id": "NCT03338296_exc_T81", "normalized": [] }, { "id": "NCT03338296_exc_R36", "type": "Has_scope", "arg1_id": "NCT03338296_exc_T78", "arg2_id": "NCT03338296_exc_T82", "normalized": [] }, { "id": "NCT03338296_exc_R37", "type": "AND", "arg1_id": "NCT03338296_exc_T70", "arg2_id": "NCT03338296_exc_T78", "normalized": [] }, { "id": "NCT03338296_exc_R38", "type": "Has_temporal", "arg1_id": "NCT03338296_exc_T83", "arg2_id": "NCT03338296_exc_T84", "normalized": [] }, { "id": "NCT03338296_exc_R39", "type": "AND", "arg1_id": "NCT03338296_exc_T85", "arg2_id": "NCT03338296_exc_T83", "normalized": [] }, { "id": "NCT03338296_exc_R40", "type": "Has_index", "arg1_id": "NCT03338296_exc_T89", "arg2_id": "NCT03338296_exc_T90", "normalized": [] }, { "id": "NCT03338296_exc_R41", "type": "Has_temporal", "arg1_id": "NCT03338296_exc_T91", "arg2_id": "NCT03338296_exc_T89", "normalized": [] }, { "id": "NCT03338296_exc_R42", "type": "Has_temporal", "arg1_id": "NCT03338296_exc_T91", "arg2_id": "NCT03338296_exc_T86", "normalized": [] }, { "id": "NCT03338296_exc_R43", "type": 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"NCT03338296_exc_R161", "type": "Has_qualifier", "arg1_id": "NCT03338296_exc_T358", "arg2_id": "NCT03338296_exc_T363", "normalized": [] }, { "id": "NCT03338296_exc_R162", "type": "Has_temporal", "arg1_id": "NCT03338296_exc_T358", "arg2_id": "NCT03338296_exc_T359", "normalized": [] }, { "id": "NCT03338296_exc_R163", "type": "Has_temporal", "arg1_id": "NCT03338296_exc_T358", "arg2_id": "NCT03338296_exc_T360", "normalized": [] } ]

[ { "id": "NCT03338296_inc_text", "type": "inclusion", "text": [ "Healthy male or female adolescents, age 12 to 17 years (inclusive) at Screening, with a body mass index (BMI) that is greater than or equal to the United States-weighted mean of the 95th percentile based on age and sex with a body weight greater than 60 kilograms (kg). Participants with Type 2 diabetes mellitus (T2DM) may have a pre-existing or new diagnosis of T2DM.\nHbA1c =6.5%\nfasting plasma glucose (FPG) =126 mg/dL (7.0 mmol/L)\nParticipants and their families not planning to move away from the area for the duration of the study\nParticipants able and willing to comply with all aspects of the study, including a standardized, reduced calorie diet and an age appropriate, increased physical activity program\nParticipants considered in stable health in the opinion of the investigator\nAble and willing to support and supervise study participation in the opinion of the investigator, including consideration of any existing physical, medical, or mental condition that prevents compliance with the protocol\nAble and willing to personally comply with and execute all aspects of the study requirements for the caregivers or guardians\n" ], "offsets": [ [ 0, 1136 ] ] } ]

[ { "id": "NCT03338296_inc_T1", "type": "Condition", "text": [ "Healthy" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T2", "type": "Person", "text": [ "male" ], "offsets": [ [ 8, 12 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T3", "type": "Person", "text": [ "female" ], "offsets": [ [ 16, 22 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T4", "type": "Person", "text": [ "adolescents" ], "offsets": [ [ 23, 34 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T5", "type": "Person", "text": [ "age" ], "offsets": [ [ 36, 39 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T6", "type": "Value", "text": [ "12 to 17 years" ], "offsets": [ [ 40, 54 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T7", "type": "Temporal", "text": [ "at Screening" ], "offsets": [ [ 67, 79 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T8", "type": "Measurement", "text": [ "body mass index (BMI)" ], "offsets": [ [ 88, 109 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T9", "type": "Value", "text": [ "greater than or equal to the United States-weighted mean of the 95th percentile" ], "offsets": [ [ 118, 197 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T10", "type": "Qualifier", "text": [ "based on age" ], "offsets": [ [ 198, 210 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T11", "type": "Qualifier", "text": [ "based on", "sex" ], "offsets": [ [ 198, 206 ], [ 215, 218 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T12", "type": "Measurement", "text": [ "body weight" ], "offsets": [ [ 226, 237 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T13", "type": "Value", "text": [ "greater than 60 kilograms (kg)" ], "offsets": [ [ 238, 268 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T14", "type": "Value", "text": [ "greater than or equal to", "the 95th percentile" ], "offsets": [ [ 118, 142 ], [ 178, 197 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T15", "type": "Scope", "text": [ "based on age and sex" ], "offsets": [ [ 198, 218 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T17", "type": "Measurement", "text": [ "HbA1c" ], "offsets": [ [ 370, 375 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T18", "type": "Value", "text": [ "=6.5%" ], "offsets": [ [ 376, 381 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T19", "type": "Measurement", "text": [ "fasting plasma glucose (FPG)" ], "offsets": [ [ 382, 410 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T20", "type": "Value", "text": [ "=126 mg/dL" ], "offsets": [ [ 411, 421 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T21", "type": "Value", "text": [ "7.0 mmol/L" ], "offsets": [ [ 423, 433 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T22", "type": "Negation", "text": [ "not" ], "offsets": [ [ 467, 470 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T23", "type": "Observation", "text": [ "planning to move away" ], "offsets": [ [ 471, 492 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T24", "type": "Temporal", "text": [ "for the duration of the study" ], "offsets": [ [ 507, 536 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T25", "type": "Reference_point", "text": [ "the study" ], "offsets": [ [ 527, 536 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T26", "type": "Observation", "text": [ "willing to comply" ], "offsets": [ [ 559, 576 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T27", "type": "Observation", "text": [ " an", "omply wit" ], "offsets": [ [ 554, 557 ], [ 571, 580 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T28", "type": "Observation", "text": [ "reduced calorie diet" ], "offsets": [ [ 634, 654 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T29", "type": "Qualifier", "text": [ "standardized" ], "offsets": [ [ 620, 632 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T30", "type": "Observation", "text": [ "increased physical activity program" ], "offsets": [ [ 679, 714 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T31", "type": "Scope", "text": [ "standardized, reduced calorie diet and an age appropriate, increased physical activity program" ], "offsets": [ [ 620, 714 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T32", "type": "Qualifier", "text": [ "age appropriate" ], "offsets": [ [ 662, 677 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T33", "type": "Scope", "text": [ "able and willing to comply" ], "offsets": [ [ 550, 576 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T34", "type": "Observation", "text": [ "stable health" ], "offsets": [ [ 742, 755 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T37", "type": "Observation", "text": [ "willing to personally comply" ], "offsets": [ [ 1020, 1048 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T38", "type": "Observation", "text": [ "d wi", "onally comply with a" ], "offsets": [ [ 1018, 1022 ], [ 1035, 1055 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T39", "type": "Person", "text": [ "caregivers" ], "offsets": [ [ 1112, 1122 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T40", "type": "Person", "text": [ "guardians" ], "offsets": [ [ 1126, 1135 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T41", "type": "Scope", "text": [ "caregivers or guardians" ], "offsets": [ [ 1112, 1135 ] ], "normalized": [] }, { "id": "NCT03338296_inc_T42", "type": "Scope", "text": [ "Able and willing to personally comply" ], "offsets": [ [ 1011, 1048 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03338296_inc_R1", "type": "Has_value", "arg1_id": "NCT03338296_inc_T5", "arg2_id": "NCT03338296_inc_T6", "normalized": [] }, { "id": "NCT03338296_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03338296_inc_T5", "arg2_id": "NCT03338296_inc_T7", "normalized": [] }, { "id": "NCT03338296_inc_R4", "type": "Has_value", "arg1_id": "NCT03338296_inc_T8", "arg2_id": "NCT03338296_inc_T9", "normalized": [] }, { "id": "NCT03338296_inc_R5", "type": "Has_scope", "arg1_id": "NCT03338296_inc_T8", "arg2_id": "NCT03338296_inc_T15", "normalized": [] }, { "id": "NCT03338296_inc_R6", "type": "Has_value", "arg1_id": "NCT03338296_inc_T12", "arg2_id": "NCT03338296_inc_T13", "normalized": [] }, { "id": "NCT03338296_inc_R7", "type": "Has_value", "arg1_id": "NCT03338296_inc_T17", "arg2_id": "NCT03338296_inc_T18", "normalized": [] }, { "id": "NCT03338296_inc_R8", "type": "Subsumes", "arg1_id": "NCT03338296_inc_T20", "arg2_id": "NCT03338296_inc_T21", "normalized": [] }, { "id": "NCT03338296_inc_R9", "type": "Has_value", "arg1_id": "NCT03338296_inc_T19", "arg2_id": "NCT03338296_inc_T20", "normalized": [] }, { "id": "NCT03338296_inc_R10", "type": "Has_index", "arg1_id": "NCT03338296_inc_T24", "arg2_id": "NCT03338296_inc_T25", "normalized": [] }, { "id": "NCT03338296_inc_R11", "type": "Has_negation", "arg1_id": "NCT03338296_inc_T23", "arg2_id": "NCT03338296_inc_T22", "normalized": [] }, { "id": "NCT03338296_inc_R12", "type": "Has_temporal", "arg1_id": "NCT03338296_inc_T23", "arg2_id": "NCT03338296_inc_T24", "normalized": [] }, { "id": "NCT03338296_inc_R13", "type": "Has_qualifier", "arg1_id": "NCT03338296_inc_T28", "arg2_id": "NCT03338296_inc_T29", "normalized": [] }, { "id": "NCT03338296_inc_R14", "type": "Has_qualifier", "arg1_id": "NCT03338296_inc_T30", "arg2_id": "NCT03338296_inc_T32", "normalized": [] }, { "id": "NCT03338296_inc_R15", "type": "Has_scope", "arg1_id": "NCT03338296_inc_T33", "arg2_id": "NCT03338296_inc_T31", "normalized": [] }, { "id": "NCT03338296_inc_R16", "type": "Has_scope", "arg1_id": "NCT03338296_inc_T42", "arg2_id": "NCT03338296_inc_T41", "normalized": [] } ]

[ { "id": "NCT03338855_exc_text", "type": "exclusion", "text": [ "Involvement in the planning and conduct of the study (applies to both AstraZeneca staff and staff at third party vendor or at the investigational sites).\nPrevious enrolment in the present study or participation in another clinical study with an investigational product during the last 3 months or as judged by the Investigator.\nHistory of or presence of any clinically significant disease or disorder including a recent (< 3 months) cardiovascular event which, in the opinion of the Investigator, may either put the patient at risk because of participation in the study or influence the results or the patient's ability to participate in the study.\nClinical diagnosis of Type 1 diabetes, maturity onset diabetes of the young, secondary diabetes or diabetes insipidus.\nUnstable/rapidly progressing renal disease or estimated Glomerular Filtration Rate < 60 mL/min (Cockcroft-Gault formula).\nClinically significant out of range values of serum levels of either alanine aminotransferase (ALT), aspartate aminotransferase (AST) or alkaline phosphatase (ALP) in the Investigator's opinion.\nContraindications to dapagliflozin according to the local label.\nUse of antidiabetic drugs other than metformin within 3 months prior to screening.\nWeight gain or loss > 5 kg in the last 3 months, ongoing weight-loss diet (hypocaloric diet) or use of weight loss agents.\nHistory of drug abuse or alcohol abuse in the past 12 months.\nAny clinically significant abnormalities in clinical chemistry, hematology or urinalysis or other condition the Investigator believes would interfere with the patient's ability to provide informed consent, comply with study instructions, or which might confound the interpretation of the study results or put the patient at undue risk.\nPlasma donation within one month of screening or any blood donation/blood loss > 500 mL within 3 months prior to screening or during the study.\nAnemia defined as Hemoglobin (Hb) < 115 g/L (7.1 mM) in women and < 120 g/L (7.5 mM) in men.\nUse of anti-coagulant treatment such as heparin, warfarin, platelet inhibitors, thrombin and factor X inhibitors.\nUse of medication such as oral glucocorticoids, anti-estrogens or other medications that are known to markedly influence insulin sensitivity.\nUse of loop diuretics.\nRegular smoking and other regular nicotine use.\nCentral nervous system aneurysm clip\nImplanted neural stimulator\nImplanted cardiac pacemaker of defibrillator\nCochlear implant\nMetal containing corpora aliena in the eye or brain.\nPatients, who do not want to be informed about unexpected medical findings, or do not wish that their physician be informed about coincidental findings, cannot participate in the study.\n" ], "offsets": [ [ 0, 2684 ] ] } ]

[ { "id": "NCT03338855_exc_T3", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 358, 380 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T4", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 381, 388 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T5", "type": "Condition", "text": [ "disorder" ], "offsets": [ [ 392, 400 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T6", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 413, 419 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T7", "type": "Temporal", "text": [ "< 3 months" ], "offsets": [ [ 421, 431 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T8", "type": "Condition", "text": [ "cardiovascular event" ], "offsets": [ [ 433, 453 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T10", "type": "Condition", "text": [ "Type 1 diabetes" ], "offsets": [ [ 671, 686 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T11", "type": "Condition", "text": [ "maturity onset diabetes of the young" ], "offsets": [ [ 688, 724 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T12", "type": "Condition", "text": [ "secondary diabetes" ], "offsets": [ [ 726, 744 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T13", "type": "Condition", "text": [ "diabetes insipidus" ], "offsets": [ [ 748, 766 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T14", "type": "Qualifier", "text": [ "rapidly progressing" ], "offsets": [ [ 777, 796 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T15", "type": "Qualifier", "text": [ "Unstable" ], "offsets": [ [ 768, 776 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T16", "type": "Condition", "text": [ "renal disease" ], "offsets": [ [ 797, 810 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T17", "type": "Measurement", "text": [ "estimated Glomerular Filtration Rate" ], "offsets": [ [ 814, 850 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T18", "type": "Value", "text": [ "< 60 mL/min" ], "offsets": [ [ 851, 862 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T19", "type": "Qualifier", "text": [ "Cockcroft-Gault formula" ], "offsets": [ [ 864, 887 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T20", "type": "Scope", "text": [ "Unstable/rapidly progressing" ], "offsets": [ [ 768, 796 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T21", "type": "Qualifier", "text": [ "Clinically significant" ], "offsets": [ [ 890, 912 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T22", "type": "Value", "text": [ "out of range values" ], "offsets": [ [ 913, 932 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T23", "type": "Measurement", "text": [ "alanine aminotransferase (ALT)" ], "offsets": [ [ 959, 989 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T24", "type": "Measurement", "text": [ "aspartate aminotransferase (AST)" ], "offsets": [ [ 991, 1023 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T25", "type": "Measurement", "text": [ "alkaline phosphatase (ALP)" ], "offsets": [ [ 1027, 1053 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T26", "type": "Scope", "text": [ "alanine aminotransferase (ALT), aspartate aminotransferase (AST) or alkaline phosphatase (ALP)" ], "offsets": [ [ 959, 1053 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T27", "type": "Drug", "text": [ "dapagliflozin" ], "offsets": [ [ 1106, 1119 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T28", "type": "Condition", "text": [ "Contraindications" ], "offsets": [ [ 1085, 1102 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T29", "type": "Drug", "text": [ "antidiabetic drugs" ], "offsets": [ [ 1157, 1175 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T30", "type": "Drug", "text": [ "metformin" ], "offsets": [ [ 1187, 1196 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T31", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 1176, 1186 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T32", "type": "Temporal", "text": [ "within 3 months prior to screening" ], "offsets": [ [ 1197, 1231 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T33", "type": "Measurement", "text": [ "Weight gain" ], "offsets": [ [ 1233, 1244 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T34", "type": "Measurement", "text": [ "ain or", " k" ], "offsets": [ [ 1241, 1247 ], [ 1256, 1258 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T35", "type": "Value", "text": [ "> 5 kg" ], "offsets": [ [ 1253, 1259 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T36", "type": "Temporal", "text": [ "in the last 3 months" ], "offsets": [ [ 1260, 1280 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T37", "type": "Observation", "text": [ "weight-loss diet" ], "offsets": [ [ 1290, 1306 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T38", "type": "Temporal", "text": [ "ongoing" ], "offsets": [ [ 1282, 1289 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T39", "type": "Observation", "text": [ "hypocaloric diet" ], "offsets": [ [ 1308, 1324 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T40", "type": "Drug", "text": [ "weight loss agents" ], "offsets": [ [ 1336, 1354 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T41", "type": "Scope", "text": [ "Weight gain or loss" ], "offsets": [ [ 1233, 1252 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T42", "type": "Observation", "text": [ "alcohol abuse" ], "offsets": [ [ 1381, 1394 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T43", "type": "Observation", "text": [ "drug abuse" ], "offsets": [ [ 1367, 1377 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T44", "type": "Temporal", "text": [ "in the past 12 months" ], "offsets": [ [ 1395, 1416 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T45", "type": "Scope", "text": [ "drug abuse or alcohol abuse" ], "offsets": [ [ 1367, 1394 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T46", "type": "Observation", "text": [ "History" ], "offsets": [ [ 1356, 1363 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T48", "type": "Procedure", "text": [ "Plasma donation" ], "offsets": [ [ 1754, 1769 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T49", "type": "Temporal", "text": [ "within one month of screening" ], "offsets": [ [ 1770, 1799 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T50", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 1790, 1799 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T51", "type": "Procedure", "text": [ "blood donation" ], "offsets": [ [ 1807, 1821 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T52", "type": "Measurement", "text": [ "blood loss" ], "offsets": [ [ 1822, 1832 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T53", "type": "Value", "text": [ "> 500 mL" ], "offsets": [ [ 1833, 1841 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T54", "type": "Scope", "text": [ "blood donation/blood loss > 500 mL" ], "offsets": [ [ 1807, 1841 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T55", "type": "Temporal", "text": [ "within 3 months prior to screening" ], "offsets": [ [ 1842, 1876 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T56", "type": "Temporal", "text": [ "during the study" ], "offsets": [ [ 1880, 1896 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T57", "type": "Scope", "text": [ "within 3 months prior to screening or during the study" ], "offsets": [ [ 1842, 1896 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T58", "type": "Condition", "text": [ "Anemia" ], "offsets": [ [ 1898, 1904 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T59", "type": "Measurement", "text": [ "Hemoglobin (Hb)" ], "offsets": [ [ 1916, 1931 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T60", "type": "Value", "text": [ "< 115 g/L" ], "offsets": [ [ 1932, 1941 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T61", "type": "Value", "text": [ "7.1 mM" ], "offsets": [ [ 1943, 1949 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T62", "type": "Person", "text": [ "women" ], "offsets": [ [ 1954, 1959 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T63", "type": "Value", "text": [ "< 120 g/L" ], "offsets": [ [ 1964, 1973 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T64", "type": "Value", "text": [ "7.5 mM" ], "offsets": [ [ 1975, 1981 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T65", "type": "Person", "text": [ "men" ], "offsets": [ [ 1986, 1989 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T66", "type": "Scope", "text": [ "< 115 g/L (7.1 mM) in women and < 120 g/L (7.5 mM) in men" ], "offsets": [ [ 1932, 1989 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T67", "type": "Scope", "text": [ "Hemoglobin (Hb) < 115 g/L (7.1 mM) in women and < 120 g/L (7.5 mM) in men" ], "offsets": [ [ 1916, 1989 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T68", "type": "Procedure", "text": [ "anti-coagulant treatment" ], "offsets": [ [ 1998, 2022 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T69", "type": "Drug", "text": [ "heparin" ], "offsets": [ [ 2031, 2038 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T70", "type": "Drug", "text": [ "warfarin" ], "offsets": [ [ 2040, 2048 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T71", "type": "Drug", "text": [ "platelet inhibitors" ], "offsets": [ [ 2050, 2069 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T72", "type": "Drug", "text": [ "thrombin" ], "offsets": [ [ 2071, 2079 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T73", "type": "Drug", "text": [ "factor X inhibitors" ], "offsets": [ [ 2084, 2103 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T74", "type": "Scope", "text": [ "heparin, warfarin, platelet inhibitors, thrombin and factor X inhibitor" ], "offsets": [ [ 2031, 2102 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T75", "type": "Drug", "text": [ "oral glucocorticoids" ], "offsets": [ [ 2131, 2151 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T76", "type": "Drug", "text": [ "anti-estrogens" ], "offsets": [ [ 2153, 2167 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T77", "type": "Drug", "text": [ "medications" ], "offsets": [ [ 2177, 2188 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T78", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 2171, 2176 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T79", "type": "Qualifier", "text": [ "markedly influence insulin sensitivity" ], "offsets": [ [ 2207, 2245 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T80", "type": "Scope", "text": [ "oral glucocorticoids, anti-estrogens or other medications" ], "offsets": [ [ 2131, 2188 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T81", "type": "Drug", "text": [ "loop diuretics" ], "offsets": [ [ 2254, 2268 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T82", "type": "Observation", "text": [ "smoking" ], "offsets": [ [ 2278, 2285 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T83", "type": "Multiplier", "text": [ "Regular" ], "offsets": [ [ 2270, 2277 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T84", "type": "Drug", "text": [ "nicotine" ], "offsets": [ [ 2304, 2312 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T85", "type": "Multiplier", "text": [ "regular" ], "offsets": [ [ 2296, 2303 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T86", "type": "Device", "text": [ "Central nervous system aneurysm clip" ], "offsets": [ [ 2318, 2354 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T87", "type": "Device", "text": [ "Implanted neural stimulator" ], "offsets": [ [ 2355, 2382 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T88", "type": "Device", "text": [ "cardiac pacemaker" ], "offsets": [ [ 2393, 2410 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T89", "type": "Device", "text": [ "defibrillator" ], "offsets": [ [ 2414, 2427 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T90", "type": "Device", "text": [ "Cochlear implant" ], "offsets": [ [ 2428, 2444 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T91", "type": "Device", "text": [ "corpora aliena in the eye" ], "offsets": [ [ 2462, 2487 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T92", "type": "Device", "text": [ " eye or brain.\nPatie", "do no" ], "offsets": [ [ 2483, 2503 ], [ 2512, 2517 ] ], "normalized": [] }, { "id": "NCT03338855_exc_T93", "type": "Qualifier", "text": [ "Metal containing" ], "offsets": [ [ 2445, 2461 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03338855_exc_R1", "type": "Subsumes", "arg1_id": "NCT03338855_exc_T6", "arg2_id": "NCT03338855_exc_T7", "normalized": [] }, { "id": "NCT03338855_exc_R2", "type": "Has_value", "arg1_id": "NCT03338855_exc_T17", "arg2_id": "NCT03338855_exc_T18", "normalized": [] }, { "id": "NCT03338855_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03338855_exc_T17", "arg2_id": "NCT03338855_exc_T19", "normalized": [] }, { "id": "NCT03338855_exc_R4", "type": "Has_scope", "arg1_id": "NCT03338855_exc_T16", "arg2_id": "NCT03338855_exc_T20", "normalized": [] }, { "id": "NCT03338855_exc_R5", "type": "Has_value", "arg1_id": "NCT03338855_exc_T26", "arg2_id": "NCT03338855_exc_T22", "normalized": [] }, { "id": "NCT03338855_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03338855_exc_T22", "arg2_id": "NCT03338855_exc_T21", "normalized": [] }, { "id": "NCT03338855_exc_R7", "type": "AND", "arg1_id": "NCT03338855_exc_T28", "arg2_id": "NCT03338855_exc_T27", "normalized": [] }, { "id": "NCT03338855_exc_R8", "type": "Has_negation", "arg1_id": "NCT03338855_exc_T30", "arg2_id": "NCT03338855_exc_T31", "normalized": [] }, { "id": "NCT03338855_exc_R9", "type": "AND", "arg1_id": "NCT03338855_exc_T29", "arg2_id": "NCT03338855_exc_T30", "normalized": [] }, { "id": "NCT03338855_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03338855_exc_T29", "arg2_id": "NCT03338855_exc_T32", "normalized": [] }, { "id": "NCT03338855_exc_R11", "type": "Has_temporal", "arg1_id": "NCT03338855_exc_T37", "arg2_id": "NCT03338855_exc_T38", "normalized": [] }, { "id": "NCT03338855_exc_R12", "type": "Subsumes", "arg1_id": "NCT03338855_exc_T37", "arg2_id": "NCT03338855_exc_T39", "normalized": [] }, { "id": "NCT03338855_exc_R13", "type": "Has_value", "arg1_id": "NCT03338855_exc_T41", "arg2_id": "NCT03338855_exc_T35", "normalized": [] }, { "id": "NCT03338855_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03338855_exc_T41", "arg2_id": "NCT03338855_exc_T36", "normalized": [] }, { "id": "NCT03338855_exc_R15", "type": "Has_temporal", "arg1_id": "NCT03338855_exc_T45", "arg2_id": "NCT03338855_exc_T44", "normalized": [] }, { "id": "NCT03338855_exc_R16", "type": "Has_temporal", "arg1_id": "NCT03338855_exc_T45", "arg2_id": "NCT03338855_exc_T46", "normalized": [] }, { "id": "NCT03338855_exc_R17", "type": "Has_temporal", "arg1_id": "NCT03338855_exc_T48", "arg2_id": "NCT03338855_exc_T49", "normalized": [] }, { "id": "NCT03338855_exc_R18", "type": "Has_index", "arg1_id": "NCT03338855_exc_T49", "arg2_id": "NCT03338855_exc_T50", "normalized": [] }, { "id": "NCT03338855_exc_R19", "type": "Has_value", "arg1_id": "NCT03338855_exc_T52", "arg2_id": "NCT03338855_exc_T53", "normalized": [] }, { "id": "NCT03338855_exc_R20", "type": "Has_scope", "arg1_id": "NCT03338855_exc_T54", "arg2_id": "NCT03338855_exc_T57", "normalized": [] }, { "id": "NCT03338855_exc_R21", "type": "Subsumes", "arg1_id": "NCT03338855_exc_T60", "arg2_id": "NCT03338855_exc_T61", "normalized": [] }, { "id": "NCT03338855_exc_R23", "type": "Subsumes", "arg1_id": "NCT03338855_exc_T63", "arg2_id": "NCT03338855_exc_T64", "normalized": [] }, { "id": "NCT03338855_exc_R24", "type": "Has_value", "arg1_id": "NCT03338855_exc_T65", "arg2_id": "NCT03338855_exc_T63", "normalized": [] }, { "id": "NCT03338855_exc_R22", "type": "Has_value", "arg1_id": "NCT03338855_exc_T62", "arg2_id": "NCT03338855_exc_T60", "normalized": [] }, { "id": "NCT03338855_exc_R25", "type": "AND", "arg1_id": "NCT03338855_exc_T66", "arg2_id": "NCT03338855_exc_T59", "normalized": [] }, { "id": "NCT03338855_exc_R26", "type": "Subsumes", "arg1_id": "NCT03338855_exc_T58", "arg2_id": "NCT03338855_exc_T67", "normalized": [] }, { "id": "NCT03338855_exc_R27", "type": "Subsumes", "arg1_id": "NCT03338855_exc_T68", "arg2_id": "NCT03338855_exc_T74", "normalized": [] }, { "id": "NCT03338855_exc_R28", "type": "Has_qualifier", "arg1_id": "NCT03338855_exc_T77", "arg2_id": "NCT03338855_exc_T78", "normalized": [] }, { "id": "NCT03338855_exc_R29", "type": "Has_qualifier", "arg1_id": "NCT03338855_exc_T80", "arg2_id": "NCT03338855_exc_T79", "normalized": [] }, { "id": "NCT03338855_exc_R30", "type": "Has_multiplier", "arg1_id": "NCT03338855_exc_T82", "arg2_id": "NCT03338855_exc_T83", "normalized": [] }, { "id": "NCT03338855_exc_R31", "type": "Has_multiplier", "arg1_id": "NCT03338855_exc_T84", "arg2_id": "NCT03338855_exc_T85", "normalized": [] }, { "id": "NCT03338855_exc_R32", "type": "Has_qualifier", "arg1_id": "NCT03338855_exc_T92", "arg2_id": "NCT03338855_exc_T93", "normalized": [] }, { "id": "NCT03338855_exc_R33", "type": "Has_qualifier", "arg1_id": "NCT03338855_exc_T91", "arg2_id": "NCT03338855_exc_T93", "normalized": [] } ]

[ { "id": "NCT03338855_inc_text", "type": "inclusion", "text": [ "Patients are able to provide signed and dated written informed consent prior to any study specific procedures.\nWomen are post-menopausal (defined as at least 1 year post cessation of menses) and aged = 45 and = 70 years. Males are aged = 40 years and = 70 years. Patients should have suitable veins for cannulation or repeated venipuncture.\nPatients are diagnosed with T2DM for at least the last 6 months.\nPatients are on no other anti-diabetic drug treatment, or on stable maximum 3000 mg daily dose metformin treatment and/or on stable dose of a DPPIV inhibitor treatment for at least the last 3 months5. HbA1c levels =6.0% (=42 mmol/mol) and =9.0% (75 mmol/mol).\nHave a body mass index (BMI) = 35 kg/m2.\n" ], "offsets": [ [ 0, 707 ] ] } ]

[ { "id": "NCT03338855_inc_T2", "type": "Person", "text": [ "Women" ], "offsets": [ [ 111, 116 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T3", "type": "Condition", "text": [ "post-menopausal" ], "offsets": [ [ 121, 136 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T4", "type": "Condition", "text": [ "T2DM" ], "offsets": [ [ 369, 373 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T5", "type": "Temporal", "text": [ "as at least 1 year post cessation of menses" ], "offsets": [ [ 146, 189 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T6", "type": "Reference_point", "text": [ "cessation of menses" ], "offsets": [ [ 170, 189 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T7", "type": "Person", "text": [ "aged" ], "offsets": [ [ 195, 199 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T8", "type": "Value", "text": [ "= 45 and = 70 years" ], "offsets": [ [ 200, 219 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T9", "type": "Person", "text": [ "Males" ], "offsets": [ [ 221, 226 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T10", "type": "Person", "text": [ "aged" ], "offsets": [ [ 231, 235 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T11", "type": "Value", "text": [ "= 40 years and = 70 years" ], "offsets": [ [ 236, 261 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T13", "type": "Scope", "text": [ "post-menopausal (defined as at least 1 year post cessation of menses) and aged = 45 and = 70 years" ], "offsets": [ [ 121, 219 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T14", "type": "Scope", "text": [ "aged = 40 years and = 70 years" ], "offsets": [ [ 231, 261 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T15", "type": "Temporal", "text": [ "for at least the last 6 months" ], "offsets": [ [ 374, 404 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T16", "type": "Procedure", "text": [ "anti-diabetic drug treatment" ], "offsets": [ [ 431, 459 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T17", "type": "Negation", "text": [ "no" ], "offsets": [ [ 422, 424 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T18", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 425, 430 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T19", "type": "Qualifier", "text": [ "stable" ], "offsets": [ [ 467, 473 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T20", "type": "Multiplier", "text": [ "maximum 3000 mg daily dose" ], "offsets": [ [ 474, 500 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T21", "type": "Drug", "text": [ "metformin" ], "offsets": [ [ 501, 510 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T22", "type": "Qualifier", "text": [ "stable dose" ], "offsets": [ [ 531, 542 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T23", "type": "Drug", "text": [ "DPPIV inhibitor" ], "offsets": [ [ 548, 563 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T24", "type": "Temporal", "text": [ "for at least the last 3 months" ], "offsets": [ [ 574, 604 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T25", "type": "Measurement", "text": [ "HbA1c levels" ], "offsets": [ [ 607, 619 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T26", "type": "Value", "text": [ "=6.0%" ], "offsets": [ [ 620, 625 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T27", "type": "Value", "text": [ "=42 mmol/mol" ], "offsets": [ [ 627, 639 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T28", "type": "Value", "text": [ "=9.0%" ], "offsets": [ [ 645, 650 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T29", "type": "Value", "text": [ "75 mmol/mol" ], "offsets": [ [ 652, 663 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T30", "type": "Scope", "text": [ "=6.0% (=42 mmol/mol) and =9.0% (75 mmol/mol)" ], "offsets": [ [ 620, 664 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T31", "type": "Measurement", "text": [ "body mass index (BMI)" ], "offsets": [ [ 673, 694 ] ], "normalized": [] }, { "id": "NCT03338855_inc_T32", "type": "Value", "text": [ "= 35 kg/m2" ], "offsets": [ [ 695, 705 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03338855_inc_R1", "type": "Has_value", "arg1_id": "NCT03338855_inc_T7", "arg2_id": "NCT03338855_inc_T8", "normalized": [] }, { "id": "NCT03338855_inc_R2", "type": "Has_value", "arg1_id": "NCT03338855_inc_T10", "arg2_id": "NCT03338855_inc_T11", "normalized": [] }, { "id": "NCT03338855_inc_R3", "type": "Has_scope", "arg1_id": "NCT03338855_inc_T9", "arg2_id": "NCT03338855_inc_T14", "normalized": [] }, { "id": "NCT03338855_inc_R4", "type": "Has_scope", "arg1_id": "NCT03338855_inc_T2", "arg2_id": "NCT03338855_inc_T13", "normalized": [] }, { "id": "NCT03338855_inc_R5", "type": "Has_temporal", "arg1_id": "NCT03338855_inc_T4", "arg2_id": "NCT03338855_inc_T15", "normalized": [] }, { "id": "NCT03338855_inc_R6", "type": "Has_qualifier", "arg1_id": "NCT03338855_inc_T16", "arg2_id": "NCT03338855_inc_T18", "normalized": [] }, { "id": "NCT03338855_inc_R7", "type": "Has_negation", "arg1_id": "NCT03338855_inc_T16", "arg2_id": "NCT03338855_inc_T17", "normalized": [] }, { "id": "NCT03338855_inc_R8", "type": "Subsumes", "arg1_id": "NCT03338855_inc_T28", "arg2_id": "NCT03338855_inc_T29", "normalized": [] }, { "id": "NCT03338855_inc_R9", "type": "Subsumes", "arg1_id": "NCT03338855_inc_T26", "arg2_id": "NCT03338855_inc_T27", "normalized": [] }, { "id": "NCT03338855_inc_R10", "type": "Has_multiplier", "arg1_id": "NCT03338855_inc_T21", "arg2_id": "NCT03338855_inc_T20", "normalized": [] }, { "id": "NCT03338855_inc_R11", "type": "Has_qualifier", "arg1_id": "NCT03338855_inc_T20", "arg2_id": "NCT03338855_inc_T19", "normalized": [] }, { "id": "NCT03338855_inc_R12", "type": "Has_qualifier", "arg1_id": "NCT03338855_inc_T23", "arg2_id": "NCT03338855_inc_T22", "normalized": [] }, { "id": "NCT03338855_inc_R13", "type": "Has_temporal", "arg1_id": "NCT03338855_inc_T23", "arg2_id": "NCT03338855_inc_T24", "normalized": [] }, { "id": "NCT03338855_inc_R14", "type": "Has_scope", "arg1_id": "NCT03338855_inc_T25", "arg2_id": "NCT03338855_inc_T30", "normalized": [] }, { "id": "NCT03338855_inc_R15", "type": "Has_value", "arg1_id": "NCT03338855_inc_T31", "arg2_id": "NCT03338855_inc_T32", "normalized": [] } ]

[ { "id": "NCT03339284_exc_text", "type": "exclusion", "text": [ "age under 18y or over 85y\ndiabetes type 1 with complications\nno co-operation or inadequate finnish language skills\npersistent pain for other reason\nsevere hepatic insufficiency or paracetamol (acetaminophen) is contraindicated for other reason\nany type of steroid in regular use\noxycodone contraindicated\nmedications changing notably paracetamol (acetaminophen) and/or ropivacaine metabolism in regular use\n" ], "offsets": [ [ 0, 407 ] ] } ]

[ { "id": "NCT03339284_exc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T2", "type": "Value", "text": [ "under 18y or over 85y" ], "offsets": [ [ 4, 25 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T3", "type": "Condition", "text": [ "diabetes type 1" ], "offsets": [ [ 26, 41 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T4", "type": "Condition", "text": [ "complications" ], "offsets": [ [ 47, 60 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T5", "type": "Observation", "text": [ "co-operation" ], "offsets": [ [ 64, 76 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T6", "type": "Negation", "text": [ "no" ], "offsets": [ [ 61, 63 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T7", "type": "Observation", "text": [ "inadequate finnish language skills" ], "offsets": [ [ 80, 114 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T8", "type": "Condition", "text": [ "persistent pain" ], "offsets": [ [ 115, 130 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T9", "type": "Qualifier", "text": [ "other reason" ], "offsets": [ [ 135, 147 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T10", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 148, 154 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T11", "type": "Condition", "text": [ "hepatic insufficiency" ], "offsets": [ [ 155, 176 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T12", "type": "Drug", "text": [ "paracetamol" ], "offsets": [ [ 180, 191 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T13", "type": "Drug", "text": [ "acetaminophen" ], "offsets": [ [ 193, 206 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T14", "type": "Condition", "text": [ "contraindicated" ], "offsets": [ [ 211, 226 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T15", "type": "Drug", "text": [ "steroid" ], "offsets": [ [ 256, 263 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T16", "type": "Multiplier", "text": [ "regular use" ], "offsets": [ [ 267, 278 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T17", "type": "Drug", "text": [ "oxycodone" ], "offsets": [ [ 279, 288 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T18", "type": "Condition", "text": [ "contraindicated" ], "offsets": [ [ 289, 304 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T19", "type": "Drug", "text": [ "paracetamol" ], "offsets": [ [ 334, 345 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T20", "type": "Drug", "text": [ "acetaminophen" ], "offsets": [ [ 347, 360 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T21", "type": "Drug", "text": [ "ropivacaine" ], "offsets": [ [ 369, 380 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T23", "type": "Multiplier", "text": [ "regular use" ], "offsets": [ [ 395, 406 ] ], "normalized": [] }, { "id": "NCT03339284_exc_T22", "type": "Scope", "text": [ "paracetamol (acetaminophen) and/or ropivacaine" ], "offsets": [ [ 334, 380 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03339284_exc_R1", "type": "Has_value", "arg1_id": "NCT03339284_exc_T1", "arg2_id": "NCT03339284_exc_T2", "normalized": [] }, { "id": "NCT03339284_exc_R2", "type": "AND", "arg1_id": "NCT03339284_exc_T3", "arg2_id": "NCT03339284_exc_T4", "normalized": [] }, { "id": "NCT03339284_exc_R3", "type": "Has_negation", "arg1_id": "NCT03339284_exc_T5", "arg2_id": "NCT03339284_exc_T6", "normalized": [] }, { "id": "NCT03339284_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03339284_exc_T8", "arg2_id": "NCT03339284_exc_T9", "normalized": [] }, { "id": "NCT03339284_exc_R5", "type": "Subsumes", "arg1_id": "NCT03339284_exc_T12", "arg2_id": "NCT03339284_exc_T13", "normalized": [] }, { "id": "NCT03339284_exc_R6", "type": "AND", "arg1_id": "NCT03339284_exc_T14", "arg2_id": "NCT03339284_exc_T12", "normalized": [] }, { "id": "NCT03339284_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03339284_exc_T11", "arg2_id": "NCT03339284_exc_T10", "normalized": [] }, { "id": "NCT03339284_exc_R8", "type": "Has_multiplier", "arg1_id": "NCT03339284_exc_T15", "arg2_id": "NCT03339284_exc_T16", "normalized": [] }, { "id": "NCT03339284_exc_R9", "type": "AND", "arg1_id": "NCT03339284_exc_T18", "arg2_id": "NCT03339284_exc_T17", "normalized": [] }, { "id": "NCT03339284_exc_R10", "type": "Subsumes", "arg1_id": "NCT03339284_exc_T19", "arg2_id": "NCT03339284_exc_T20", "normalized": [] }, { "id": "NCT03339284_exc_R11", "type": "Has_multiplier", "arg1_id": "NCT03339284_exc_T22", "arg2_id": "NCT03339284_exc_T23", "normalized": [] } ]

[ { "id": "NCT03339284_inc_text", "type": "inclusion", "text": [ "patients with renal cancer coming to the laparoscopic radical nephrectomy\n" ], "offsets": [ [ 0, 74 ] ] } ]

[ { "id": "NCT03339284_inc_T1", "type": "Condition", "text": [ "renal cancer" ], "offsets": [ [ 14, 26 ] ], "normalized": [] }, { "id": "NCT03339284_inc_T2", "type": "Qualifier", "text": [ "laparoscopic" ], "offsets": [ [ 41, 53 ] ], "normalized": [] }, { "id": "NCT03339284_inc_T3", "type": "Procedure", "text": [ "radical nephrectomy" ], "offsets": [ [ 54, 73 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03339284_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03339284_inc_T3", "arg2_id": "NCT03339284_inc_T2", "normalized": [] } ]

[ { "id": "NCT03340740_exc_text", "type": "exclusion", "text": [ "Use of antihistamine within the past 72 hours\nChronic Pulmonary Condition other than asthma\nOther contraindication to cetirizine\nSevere asthma exacerbation requiring resuscitation\n" ], "offsets": [ [ 0, 180 ] ] } ]

[ { "id": "NCT03340740_exc_T1", "type": "Drug", "text": [ "antihistamine" ], "offsets": [ [ 7, 20 ] ], "normalized": [] }, { "id": "NCT03340740_exc_T2", "type": "Temporal", "text": [ "within the past 72 hours" ], "offsets": [ [ 21, 45 ] ], "normalized": [] }, { "id": "NCT03340740_exc_T3", "type": "Condition", "text": [ "Chronic Pulmonary Condition" ], "offsets": [ [ 46, 73 ] ], "normalized": [] }, { "id": "NCT03340740_exc_T4", "type": "Condition", "text": [ "asthma" ], "offsets": [ [ 85, 91 ] ], "normalized": [] }, { "id": "NCT03340740_exc_T5", "type": "Negation", "text": [ "other" ], "offsets": [ [ 74, 79 ] ], "normalized": [] }, { "id": "NCT03340740_exc_T6", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 98, 114 ] ], "normalized": [] }, { "id": "NCT03340740_exc_T7", "type": "Drug", "text": [ "cetirizine" ], "offsets": [ [ 118, 128 ] ], "normalized": [] }, { "id": "NCT03340740_exc_T8", "type": "Condition", "text": [ "asthma exacerbation" ], "offsets": [ [ 136, 155 ] ], "normalized": [] }, { "id": "NCT03340740_exc_T9", "type": "Procedure", "text": [ "resuscitation" ], "offsets": [ [ 166, 179 ] ], "normalized": [] }, { "id": "NCT03340740_exc_T10", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 129, 135 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03340740_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03340740_exc_T1", "arg2_id": "NCT03340740_exc_T2", "normalized": [] }, { "id": "NCT03340740_exc_R2", "type": "Has_negation", "arg1_id": "NCT03340740_exc_T4", "arg2_id": "NCT03340740_exc_T5", "normalized": [] }, { "id": "NCT03340740_exc_R3", "type": "AND", "arg1_id": "NCT03340740_exc_T6", "arg2_id": "NCT03340740_exc_T7", "normalized": [] }, { "id": "NCT03340740_exc_R4", "type": "AND", "arg1_id": "NCT03340740_exc_T8", "arg2_id": "NCT03340740_exc_T9", "normalized": [] }, { "id": "NCT03340740_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03340740_exc_T8", "arg2_id": "NCT03340740_exc_T10", "normalized": [] } ]

[ { "id": "NCT03340740_inc_text", "type": "inclusion", "text": [ "History of allergic rhinitis\nWheezing\n" ], "offsets": [ [ 0, 38 ] ] } ]

[ { "id": "NCT03340740_inc_T1", "type": "Condition", "text": [ "allergic rhinitis" ], "offsets": [ [ 11, 28 ] ], "normalized": [] }, { "id": "NCT03340740_inc_T2", "type": "Condition", "text": [ "Wheezing" ], "offsets": [ [ 29, 37 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03344042_exc_text", "type": "exclusion", "text": [ "no consent\nknown allergy to administered opioid\ncontraindications to epidural analgesia\ncoagulopathies including platelet count of less than 100,000\nspine surgery in past\n" ], "offsets": [ [ 0, 171 ] ] } ]

[ { "id": "NCT03344042_exc_T2", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 17, 24 ] ], "normalized": [] }, { "id": "NCT03344042_exc_T3", "type": "Drug", "text": [ "opioid" ], "offsets": [ [ 41, 47 ] ], "normalized": [] }, { "id": "NCT03344042_exc_T4", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 48, 65 ] ], "normalized": [] }, { "id": "NCT03344042_exc_T5", "type": "Procedure", "text": [ "epidural analgesia" ], "offsets": [ [ 69, 87 ] ], "normalized": [] }, { "id": "NCT03344042_exc_T6", "type": "Condition", "text": [ "coagulopathies" ], "offsets": [ [ 88, 102 ] ], "normalized": [] }, { "id": "NCT03344042_exc_T7", "type": "Measurement", "text": [ "platelet count" ], "offsets": [ [ 113, 127 ] ], "normalized": [] }, { "id": "NCT03344042_exc_T8", "type": "Value", "text": [ "less than 100,000" ], "offsets": [ [ 131, 148 ] ], "normalized": [] }, { "id": "NCT03344042_exc_T9", "type": "Scope", "text": [ "platelet count of less than 100,000" ], "offsets": [ [ 113, 148 ] ], "normalized": [] }, { "id": "NCT03344042_exc_T10", "type": "Procedure", "text": [ "spine surgery" ], "offsets": [ [ 149, 162 ] ], "normalized": [] }, { "id": "NCT03344042_exc_T11", "type": "Temporal", "text": [ "in past" ], "offsets": [ [ 163, 170 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03344042_exc_R1", "type": "AND", "arg1_id": "NCT03344042_exc_T2", "arg2_id": "NCT03344042_exc_T3", "normalized": [] }, { "id": "NCT03344042_exc_R2", "type": "AND", "arg1_id": "NCT03344042_exc_T4", "arg2_id": "NCT03344042_exc_T5", "normalized": [] }, { "id": "NCT03344042_exc_R3", "type": "Has_value", "arg1_id": "NCT03344042_exc_T7", "arg2_id": "NCT03344042_exc_T8", "normalized": [] }, { "id": "NCT03344042_exc_R4", "type": "Has_scope", "arg1_id": "NCT03344042_exc_T6", "arg2_id": "NCT03344042_exc_T9", "normalized": [] }, { "id": "NCT03344042_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03344042_exc_T10", "arg2_id": "NCT03344042_exc_T11", "normalized": [] } ]

[ { "id": "NCT03344042_inc_text", "type": "inclusion", "text": [ "parturient in labour without cervical dilation and regular uterine contractions\n" ], "offsets": [ [ 0, 80 ] ] } ]

[ { "id": "NCT03344042_inc_T1", "type": "Procedure", "text": [ "labour" ], "offsets": [ [ 14, 20 ] ], "normalized": [] }, { "id": "NCT03344042_inc_T2", "type": "Person", "text": [ "parturient" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT03344042_inc_T3", "type": "Negation", "text": [ "without" ], "offsets": [ [ 21, 28 ] ], "normalized": [] }, { "id": "NCT03344042_inc_T4", "type": "Procedure", "text": [ "cervical dilation" ], "offsets": [ [ 29, 46 ] ], "normalized": [] }, { "id": "NCT03344042_inc_T5", "type": "Condition", "text": [ "regular uterine contractions" ], "offsets": [ [ 51, 79 ] ], "normalized": [] }, { "id": "NCT03344042_inc_T6", "type": "Scope", "text": [ "cervical dilation and regular uterine contractions" ], "offsets": [ [ 29, 79 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03344042_inc_R1", "type": "Has_negation", "arg1_id": "NCT03344042_inc_T6", "arg2_id": "NCT03344042_inc_T3", "normalized": [] } ]

[ { "id": "NCT03344887_exc_text", "type": "exclusion", "text": [ "Patients that do not have a valid Ontario Health Insurance Plan (OHIP) number at time of first transfusion\nPatients that require emergent release of a RBC transfusion and in whom emergency randomization could not be completed\nPatients with complex antibody profile in which it is impossible to match RBC units\n" ], "offsets": [ [ 0, 310 ] ] } ]

[ { "id": "NCT03344887_exc_T1", "type": "Observation", "text": [ "have a valid Ontario Health Insurance Plan (OHIP) number" ], "offsets": [ [ 21, 77 ] ], "normalized": [] }, { "id": "NCT03344887_exc_T2", "type": "Negation", "text": [ "not" ], "offsets": [ [ 17, 20 ] ], "normalized": [] }, { "id": "NCT03344887_exc_T3", "type": "Temporal", "text": [ "at time of first transfusion" ], "offsets": [ [ 78, 106 ] ], "normalized": [] }, { "id": "NCT03344887_exc_T4", "type": "Reference_point", "text": [ "first transfusion" ], "offsets": [ [ 89, 106 ] ], "normalized": [] }, { "id": "NCT03344887_exc_T5", "type": "Procedure", "text": [ "transfusion" ], "offsets": [ [ 95, 106 ] ], "normalized": [] }, { "id": "NCT03344887_exc_T6", "type": "Multiplier", "text": [ "first" ], "offsets": [ [ 89, 94 ] ], "normalized": [] }, { "id": "NCT03344887_exc_T7", "type": "Procedure", "text": [ "RBC transfusion" ], "offsets": [ [ 151, 166 ] ], "normalized": [] }, { "id": "NCT03344887_exc_T8", "type": "Procedure", "text": [ "emergency randomization" ], "offsets": [ [ 179, 202 ] ], "normalized": [] }, { "id": "NCT03344887_exc_T9", "type": "Qualifier", "text": [ "emergent release" ], "offsets": [ [ 129, 145 ] ], "normalized": [] }, { "id": "NCT03344887_exc_T10", "type": "Mood", "text": [ "require" ], "offsets": [ [ 121, 128 ] ], "normalized": [] }, { "id": "NCT03344887_exc_T11", "type": "Negation", "text": [ "could not be completed" ], "offsets": [ [ 203, 225 ] ], "normalized": [] }, { "id": "NCT03344887_exc_T12", "type": "Condition", "text": [ "complex antibody profile" ], "offsets": [ [ 240, 264 ] ], "normalized": [] }, { "id": "NCT03344887_exc_T13", "type": "Observation", "text": [ "impossible to match RBC units" ], "offsets": [ [ 280, 309 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03344887_exc_R1", "type": "Has_negation", "arg1_id": "NCT03344887_exc_T1", "arg2_id": "NCT03344887_exc_T2", "normalized": [] }, { "id": "NCT03344887_exc_R2", "type": "Has_index", "arg1_id": "NCT03344887_exc_T3", "arg2_id": "NCT03344887_exc_T4", "normalized": [] }, { "id": "NCT03344887_exc_R3", "type": "Has_multiplier", "arg1_id": "NCT03344887_exc_T5", "arg2_id": "NCT03344887_exc_T6", "normalized": [] }, { "id": "NCT03344887_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03344887_exc_T1", "arg2_id": "NCT03344887_exc_T3", "normalized": [] }, { "id": "NCT03344887_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03344887_exc_T7", "arg2_id": "NCT03344887_exc_T9", "normalized": [] }, { "id": "NCT03344887_exc_R7", "type": "Has_mood", "arg1_id": "NCT03344887_exc_T7", "arg2_id": "NCT03344887_exc_T10", "normalized": [] }, { "id": "NCT03344887_exc_R8", "type": "Has_negation", "arg1_id": "NCT03344887_exc_T8", "arg2_id": "NCT03344887_exc_T11", "normalized": [] } ]

[ { "id": "NCT03344887_inc_text", "type": "inclusion", "text": [ "All patients (excluding neonates) requiring one or more allogeneic RBC transfusions for the treatment of anemia will be included.\n" ], "offsets": [ [ 0, 130 ] ] } ]

[ { "id": "NCT03344887_inc_T1", "type": "Person", "text": [ "neonates" ], "offsets": [ [ 24, 32 ] ], "normalized": [] }, { "id": "NCT03344887_inc_T2", "type": "Negation", "text": [ "excluding" ], "offsets": [ [ 14, 23 ] ], "normalized": [] }, { "id": "NCT03344887_inc_T3", "type": "Multiplier", "text": [ "one or more" ], "offsets": [ [ 44, 55 ] ], "normalized": [] }, { "id": "NCT03344887_inc_T4", "type": "Procedure", "text": [ "RBC transfusions" ], "offsets": [ [ 67, 83 ] ], "normalized": [] }, { "id": "NCT03344887_inc_T5", "type": "Qualifier", "text": [ "allogeneic" ], "offsets": [ [ 56, 66 ] ], "normalized": [] }, { "id": "NCT03344887_inc_T6", "type": "Condition", "text": [ "anemia" ], "offsets": [ [ 105, 111 ] ], "normalized": [] }, { "id": "NCT03344887_inc_T7", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 92, 101 ] ], "normalized": [] }, { "id": "NCT03344887_inc_T8", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 34, 43 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03344887_inc_R1", "type": "Has_negation", "arg1_id": "NCT03344887_inc_T1", "arg2_id": "NCT03344887_inc_T2", "normalized": [] }, { "id": "NCT03344887_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03344887_inc_T4", "arg2_id": "NCT03344887_inc_T5", "normalized": [] }, { "id": "NCT03344887_inc_R3", "type": "AND", "arg1_id": "NCT03344887_inc_T7", "arg2_id": "NCT03344887_inc_T6", "normalized": [] }, { "id": "NCT03344887_inc_R4", "type": "AND", "arg1_id": "NCT03344887_inc_T4", "arg2_id": "NCT03344887_inc_T7", "normalized": [] }, { "id": "NCT03344887_inc_R5", "type": "Has_multiplier", "arg1_id": "NCT03344887_inc_T4", "arg2_id": "NCT03344887_inc_T3", "normalized": [] }, { "id": "NCT03344887_inc_R6", "type": "Has_mood", "arg1_id": "NCT03344887_inc_T4", "arg2_id": "NCT03344887_inc_T8", "normalized": [] } ]

[ { "id": "NCT03345589_exc_text", "type": "exclusion", "text": [ "Autoimmune hepatitis\nPrimary sclerosing cholangitis\n" ], "offsets": [ [ 0, 52 ] ] } ]

[ { "id": "NCT03345589_exc_T1", "type": "Condition", "text": [ "Autoimmune hepatitis" ], "offsets": [ [ 0, 20 ] ], "normalized": [] }, { "id": "NCT03345589_exc_T2", "type": "Condition", "text": [ "Primary sclerosing cholangitis" ], "offsets": [ [ 21, 51 ] ], "normalized": [] } ]

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[ { "id": "NCT03345589_inc_text", "type": "inclusion", "text": [ "Patients diagnosed with primary biliary cholangitis\nTreated with Ursodeoxycholic Acid in West China Hospital for at least 6 month and suboptimal response to Ursodeoxycholic Acid\n" ], "offsets": [ [ 0, 178 ] ] } ]

[ { "id": "NCT03345589_inc_T1", "type": "Condition", "text": [ "primary biliary cholangitis" ], "offsets": [ [ 24, 51 ] ], "normalized": [] }, { "id": "NCT03345589_inc_T2", "type": "Drug", "text": [ "Ursodeoxycholic Acid" ], "offsets": [ [ 65, 85 ] ], "normalized": [] }, { "id": "NCT03345589_inc_T3", "type": "Visit", "text": [ "West China Hospital" ], "offsets": [ [ 89, 108 ] ], "normalized": [] }, { "id": "NCT03345589_inc_T4", "type": "Temporal", "text": [ "for at least 6 month" ], "offsets": [ [ 109, 129 ] ], "normalized": [] }, { "id": "NCT03345589_inc_T5", "type": "Condition", "text": [ "suboptimal response" ], "offsets": [ [ 134, 153 ] ], "normalized": [] }, { "id": "NCT03345589_inc_T6", "type": "Drug", "text": [ "Ursodeoxycholic Acid" ], "offsets": [ [ 157, 177 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03345589_inc_R1", "type": "AND", "arg1_id": "NCT03345589_inc_T5", "arg2_id": "NCT03345589_inc_T6", "normalized": [] }, { "id": "NCT03345589_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03345589_inc_T2", "arg2_id": "NCT03345589_inc_T4", "normalized": [] }, { "id": "NCT03345589_inc_R3", "type": "AND", "arg1_id": "NCT03345589_inc_T2", "arg2_id": "NCT03345589_inc_T3", "normalized": [] } ]

[ { "id": "NCT03347513_exc_text", "type": "exclusion", "text": [ "Severe Iron deficiency anemia (hemoglobin < 8.0 g/dL).\nParasitic worm infection e.g. schistosomiasis, and hook worm by stool analysis.\nAny cases giving clinical symptoms of gastritis e.g. nausea, vomiting, dull aching pain or soreness in the epigastrium.\nCases with history of gastric ulcer diagnosed by upper endoscopy.\nCases complaining of hematemesis.\n" ], "offsets": [ [ 0, 355 ] ] } ]

[ { "id": "NCT03347513_exc_T1", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T2", "type": "Condition", "text": [ "Iron deficiency anemia" ], "offsets": [ [ 7, 29 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T3", "type": "Measurement", "text": [ "hemoglobin" ], "offsets": [ [ 31, 41 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T4", "type": "Value", "text": [ "< 8.0 g/dL" ], "offsets": [ [ 42, 52 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T5", "type": "Scope", "text": [ "hemoglobin < 8.0 g/dL" ], "offsets": [ [ 31, 52 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T6", "type": "Scope", "text": [ "Severe Iron deficiency anemia" ], "offsets": [ [ 0, 29 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T7", "type": "Condition", "text": [ "Parasitic worm infection" ], "offsets": [ [ 55, 79 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T8", "type": "Condition", "text": [ "schistosomiasis" ], "offsets": [ [ 85, 100 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T9", "type": "Condition", "text": [ "hook worm" ], "offsets": [ [ 106, 115 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T10", "type": "Procedure", "text": [ "stool analysis" ], "offsets": [ [ 119, 133 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T11", "type": "Scope", "text": [ "schistosomiasis, and hook worm" ], "offsets": [ [ 85, 115 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T12", "type": "Mood", "text": [ "clinical symptoms" ], "offsets": [ [ 152, 169 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T13", "type": "Condition", "text": [ "gastritis" ], "offsets": [ [ 173, 182 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T14", "type": "Condition", "text": [ "nausea" ], "offsets": [ [ 188, 194 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T15", "type": "Condition", "text": [ "vomiting" ], "offsets": [ [ 196, 204 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T16", "type": "Condition", "text": [ "dull aching pain" ], "offsets": [ [ 206, 222 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T17", "type": "Condition", "text": [ "soreness in the epigastrium" ], "offsets": [ [ 226, 253 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T18", "type": "Scope", "text": [ "nausea, vomiting, dull aching pain or soreness in the epigastrium" ], "offsets": [ [ 188, 253 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T19", "type": "Scope", "text": [ "clinical symptoms of gastritis" ], "offsets": [ [ 152, 182 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T20", "type": "Condition", "text": [ "gastric ulcer" ], "offsets": [ [ 277, 290 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T21", "type": "Observation", "text": [ "history" ], "offsets": [ [ 266, 273 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T22", "type": "Procedure", "text": [ "upper endoscopy" ], "offsets": [ [ 304, 319 ] ], "normalized": [] }, { "id": "NCT03347513_exc_T23", "type": "Condition", "text": [ "hematemesis" ], "offsets": [ [ 342, 353 ] ], "normalized": [] } ]

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[ { "id": "NCT03347513_exc_R1", "type": "Has_value", "arg1_id": "NCT03347513_exc_T3", "arg2_id": "NCT03347513_exc_T4", "normalized": [] }, { "id": "NCT03347513_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03347513_exc_T2", "arg2_id": "NCT03347513_exc_T1", "normalized": [] }, { "id": "NCT03347513_exc_R3", "type": "Subsumes", "arg1_id": "NCT03347513_exc_T6", "arg2_id": "NCT03347513_exc_T5", "normalized": [] }, { "id": "NCT03347513_exc_R4", "type": "Subsumes", "arg1_id": "NCT03347513_exc_T7", "arg2_id": "NCT03347513_exc_T11", "normalized": [] }, { "id": "NCT03347513_exc_R5", "type": "AND", "arg1_id": "NCT03347513_exc_T10", "arg2_id": "NCT03347513_exc_T7", "normalized": [] }, { "id": "NCT03347513_exc_R6", "type": "Has_mood", "arg1_id": "NCT03347513_exc_T13", "arg2_id": "NCT03347513_exc_T12", "normalized": [] }, { "id": "NCT03347513_exc_R7", "type": "Subsumes", "arg1_id": "NCT03347513_exc_T19", "arg2_id": "NCT03347513_exc_T18", "normalized": [] }, { "id": "NCT03347513_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03347513_exc_T20", "arg2_id": "NCT03347513_exc_T21", "normalized": [] }, { "id": "NCT03347513_exc_R9", "type": "AND", "arg1_id": "NCT03347513_exc_T20", "arg2_id": "NCT03347513_exc_T22", "normalized": [] } ]

[ { "id": "NCT03347513_inc_text", "type": "inclusion", "text": [ "Diagnosed Iron deficiency anemia.\nH-pylori positive cases.\nSecond trimester pregnancy.\n" ], "offsets": [ [ 0, 87 ] ] } ]

[ { "id": "NCT03347513_inc_T1", "type": "Condition", "text": [ "Iron deficiency anemia" ], "offsets": [ [ 10, 32 ] ], "normalized": [] }, { "id": "NCT03347513_inc_T2", "type": "Condition", "text": [ "H-pylori positive" ], "offsets": [ [ 34, 51 ] ], "normalized": [] }, { "id": "NCT03347513_inc_T3", "type": "Qualifier", "text": [ "Second trimester" ], "offsets": [ [ 59, 75 ] ], "normalized": [] }, { "id": "NCT03347513_inc_T4", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 76, 85 ] ], "normalized": [] }, { "id": "NCT03347513_inc_T5", "type": "Temporal", "text": [ "Second trimester" ], "offsets": [ [ 59, 75 ] ], "normalized": [] } ]

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[ { "id": "NCT03347513_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03347513_inc_T4", "arg2_id": "NCT03347513_inc_T3", "normalized": [] } ]