id
stringlengths 15
15
| document_id
stringlengths 11
11
| passages
list | entities
list | events
list | coreferences
list | relations
list |
|---|---|---|---|---|---|---|
NCT03159507_exc | NCT03159507 | [
{
"id": "NCT03159507_exc_text",
"type": "exclusion",
"text": [
"Allergy known to fish\nPregnant women who breast-feed or test positive for pregnancy\n"
],
"offsets": [
[
0,
84
]
]
}
] | [
{
"id": "NCT03159507_exc_T1",
"type": "Condition",
"text": [
"Allergy"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "NCT03159507_exc_T2",
"type": "Drug",
"text": [
"fish"
],
"offsets": [
[
17,
21
]
],
"normalized": []
},
{
"id": "NCT03159507_exc_T3",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
22,
30
]
],
"normalized": []
},
{
"id": "NCT03159507_exc_T4",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
31,
36
]
],
"normalized": []
},
{
"id": "NCT03159507_exc_T5",
"type": "Condition",
"text": [
"breast-feed"
],
"offsets": [
[
41,
52
]
],
"normalized": []
},
{
"id": "NCT03159507_exc_T7",
"type": "Measurement",
"text": [
"est",
"or pregnancy"
],
"offsets": [
[
57,
60
],
[
71,
83
]
],
"normalized": []
},
{
"id": "NCT03159507_exc_T8",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
61,
69
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03159507_exc_R1",
"type": "AND",
"arg1_id": "NCT03159507_exc_T1",
"arg2_id": "NCT03159507_exc_T2",
"normalized": []
},
{
"id": "NCT03159507_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03159507_exc_T7",
"arg2_id": "NCT03159507_exc_T8",
"normalized": []
}
] |
NCT03159507_inc | NCT03159507 | [
{
"id": "NCT03159507_inc_text",
"type": "inclusion",
"text": [
"Participant aged 19 or over\nAvailable for the entire duration of the study and willing to participate on the basis of the information provided in the FIU duly read and signed.\n"
],
"offsets": [
[
0,
176
]
]
}
] | [
{
"id": "NCT03159507_inc_T1",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
12,
16
]
],
"normalized": []
},
{
"id": "NCT03159507_inc_T2",
"type": "Value",
"text": [
"19 or over"
],
"offsets": [
[
17,
27
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03159507_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03159507_inc_T1",
"arg2_id": "NCT03159507_inc_T2",
"normalized": []
}
] |
NCT03164096_exc | NCT03164096 | [
{
"id": "NCT03164096_exc_text",
"type": "exclusion",
"text": [
"Patients with coagulopathy or under anti-coagulation therapy.\nGastrointestinal disease,\nmotion sickness.\ndiabetes mellitus.\nPatients with preeclampsia,\n"
],
"offsets": [
[
0,
152
]
]
}
] | [
{
"id": "NCT03164096_exc_T1",
"type": "Condition",
"text": [
"coagulopathy"
],
"offsets": [
[
14,
26
]
],
"normalized": []
},
{
"id": "NCT03164096_exc_T2",
"type": "Procedure",
"text": [
"anti-coagulation therapy"
],
"offsets": [
[
36,
60
]
],
"normalized": []
},
{
"id": "NCT03164096_exc_T3",
"type": "Condition",
"text": [
"Gastrointestinal disease"
],
"offsets": [
[
62,
86
]
],
"normalized": []
},
{
"id": "NCT03164096_exc_T4",
"type": "Condition",
"text": [
"motion sickness"
],
"offsets": [
[
88,
103
]
],
"normalized": []
},
{
"id": "NCT03164096_exc_T5",
"type": "Condition",
"text": [
"diabetes mellitus"
],
"offsets": [
[
105,
122
]
],
"normalized": []
},
{
"id": "NCT03164096_exc_T6",
"type": "Condition",
"text": [
"preeclampsia"
],
"offsets": [
[
138,
150
]
],
"normalized": []
}
] | [] | [] | [] |
NCT03164096_inc | NCT03164096 | [
{
"id": "NCT03164096_inc_text",
"type": "inclusion",
"text": [
"adult female partner\naged 18 to 40 years.\nscheduled for elective cesarean section.\n"
],
"offsets": [
[
0,
83
]
]
}
] | [
{
"id": "NCT03164096_inc_T1",
"type": "Person",
"text": [
"adult"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT03164096_inc_T2",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
6,
12
]
],
"normalized": []
},
{
"id": "NCT03164096_inc_T3",
"type": "Observation",
"text": [
"female partner"
],
"offsets": [
[
6,
20
]
],
"normalized": []
},
{
"id": "NCT03164096_inc_T4",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
21,
25
]
],
"normalized": []
},
{
"id": "NCT03164096_inc_T5",
"type": "Value",
"text": [
"18 to 40 years"
],
"offsets": [
[
26,
40
]
],
"normalized": []
},
{
"id": "NCT03164096_inc_T6",
"type": "Procedure",
"text": [
"cesarean section"
],
"offsets": [
[
65,
81
]
],
"normalized": []
},
{
"id": "NCT03164096_inc_T7",
"type": "Qualifier",
"text": [
"elective"
],
"offsets": [
[
56,
64
]
],
"normalized": []
},
{
"id": "NCT03164096_inc_T8",
"type": "Mood",
"text": [
"scheduled for"
],
"offsets": [
[
42,
55
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03164096_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03164096_inc_T4",
"arg2_id": "NCT03164096_inc_T5",
"normalized": []
},
{
"id": "NCT03164096_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT03164096_inc_T6",
"arg2_id": "NCT03164096_inc_T7",
"normalized": []
},
{
"id": "NCT03164096_inc_R4",
"type": "Has_mood",
"arg1_id": "NCT03164096_inc_T6",
"arg2_id": "NCT03164096_inc_T8",
"normalized": []
}
] |
NCT03164304_exc | NCT03164304 | [
{
"id": "NCT03164304_exc_text",
"type": "exclusion",
"text": [
"Women with Non-proteinuric hypertension\nsevere renal impairment\nMyasthenia gravis\nHigh amount of magnesium in blood\nLow or high amount of calcium in blood\nMyocardial damage, diabetic coma, heart block\n"
],
"offsets": [
[
0,
201
]
]
}
] | [
{
"id": "NCT03164304_exc_T1",
"type": "Condition",
"text": [
"Non-proteinuric hypertension"
],
"offsets": [
[
11,
39
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T2",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T3",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
40,
46
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T4",
"type": "Condition",
"text": [
"renal impairment"
],
"offsets": [
[
47,
63
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T5",
"type": "Condition",
"text": [
"Myasthenia gravis"
],
"offsets": [
[
64,
81
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T6",
"type": "Value",
"text": [
"High amount"
],
"offsets": [
[
82,
93
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T7",
"type": "Measurement",
"text": [
"magnesium in blood"
],
"offsets": [
[
97,
115
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T8",
"type": "Value",
"text": [
"or",
"nt of"
],
"offsets": [
[
120,
122
],
[
132,
137
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T9",
"type": "Value",
"text": [
"high amount"
],
"offsets": [
[
123,
134
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T10",
"type": "Measurement",
"text": [
"calcium in blood"
],
"offsets": [
[
138,
154
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T11",
"type": "Scope",
"text": [
"Low or high amount"
],
"offsets": [
[
116,
134
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T12",
"type": "Condition",
"text": [
"Myocardial damage"
],
"offsets": [
[
155,
172
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T13",
"type": "Condition",
"text": [
"diabetic coma"
],
"offsets": [
[
174,
187
]
],
"normalized": []
},
{
"id": "NCT03164304_exc_T14",
"type": "Condition",
"text": [
"heart block"
],
"offsets": [
[
189,
200
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03164304_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03164304_exc_T4",
"arg2_id": "NCT03164304_exc_T3",
"normalized": []
},
{
"id": "NCT03164304_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03164304_exc_T7",
"arg2_id": "NCT03164304_exc_T6",
"normalized": []
},
{
"id": "NCT03164304_exc_R3",
"type": "Has_scope",
"arg1_id": "NCT03164304_exc_T10",
"arg2_id": "NCT03164304_exc_T11",
"normalized": []
}
] |
NCT03164304_inc | NCT03164304 | [
{
"id": "NCT03164304_inc_text",
"type": "inclusion",
"text": [
"Pregnant women admitted to Women health hospital with a diagnosis of severe pre-eclampsia\n"
],
"offsets": [
[
0,
90
]
]
}
] | [
{
"id": "NCT03164304_inc_T1",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT03164304_inc_T2",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
9,
14
]
],
"normalized": []
},
{
"id": "NCT03164304_inc_T3",
"type": "Procedure",
"text": [
"admitted to"
],
"offsets": [
[
15,
26
]
],
"normalized": []
},
{
"id": "NCT03164304_inc_T4",
"type": "Visit",
"text": [
"Women health hospital"
],
"offsets": [
[
27,
48
]
],
"normalized": []
},
{
"id": "NCT03164304_inc_T5",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
69,
75
]
],
"normalized": []
},
{
"id": "NCT03164304_inc_T6",
"type": "Condition",
"text": [
"pre-eclampsia"
],
"offsets": [
[
76,
89
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03164304_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03164304_inc_T6",
"arg2_id": "NCT03164304_inc_T5",
"normalized": []
},
{
"id": "NCT03164304_inc_R2",
"type": "AND",
"arg1_id": "NCT03164304_inc_T3",
"arg2_id": "NCT03164304_inc_T4",
"normalized": []
}
] |
NCT03168178_exc | NCT03168178 | [
{
"id": "NCT03168178_exc_text",
"type": "exclusion",
"text": [
"Known fetal anomaly\nOther indication for intrapartum antibiotics (endocarditis prophylaxis, other known maternal infection)\n"
],
"offsets": [
[
0,
124
]
]
}
] | [
{
"id": "NCT03168178_exc_T1",
"type": "Condition",
"text": [
"fetal anomaly"
],
"offsets": [
[
6,
19
]
],
"normalized": []
},
{
"id": "NCT03168178_exc_T2",
"type": "Condition",
"text": [
"indication"
],
"offsets": [
[
26,
36
]
],
"normalized": []
},
{
"id": "NCT03168178_exc_T3",
"type": "Drug",
"text": [
"intrapartum antibiotics"
],
"offsets": [
[
41,
64
]
],
"normalized": []
},
{
"id": "NCT03168178_exc_T4",
"type": "Condition",
"text": [
"endocarditis prophylaxis"
],
"offsets": [
[
66,
90
]
],
"normalized": []
},
{
"id": "NCT03168178_exc_T5",
"type": "Condition",
"text": [
"maternal infection"
],
"offsets": [
[
104,
122
]
],
"normalized": []
},
{
"id": "NCT03168178_exc_T6",
"type": "Scope",
"text": [
"indication for intrapartum antibiotics"
],
"offsets": [
[
26,
64
]
],
"normalized": []
},
{
"id": "NCT03168178_exc_T7",
"type": "Scope",
"text": [
"endocarditis prophylaxis, other known maternal infection"
],
"offsets": [
[
66,
122
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03168178_exc_R1",
"type": "AND",
"arg1_id": "NCT03168178_exc_T2",
"arg2_id": "NCT03168178_exc_T3",
"normalized": []
},
{
"id": "NCT03168178_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT03168178_exc_T6",
"arg2_id": "NCT03168178_exc_T7",
"normalized": []
}
] |
NCT03168178_inc | NCT03168178 | [
{
"id": "NCT03168178_inc_text",
"type": "inclusion",
"text": [
"Pregnant women between 34-42 weeks gestation\nSingleton fetus\nAdmitted for labor management & develops a fever of 100.4 F or greater\n"
],
"offsets": [
[
0,
132
]
]
}
] | [
{
"id": "NCT03168178_inc_T1",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT03168178_inc_T2",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
9,
14
]
],
"normalized": []
},
{
"id": "NCT03168178_inc_T3",
"type": "Value",
"text": [
"between 34-42 weeks"
],
"offsets": [
[
15,
34
]
],
"normalized": []
},
{
"id": "NCT03168178_inc_T4",
"type": "Measurement",
"text": [
"gestation"
],
"offsets": [
[
35,
44
]
],
"normalized": []
},
{
"id": "NCT03168178_inc_T5",
"type": "Condition",
"text": [
"Singleton fetus"
],
"offsets": [
[
45,
60
]
],
"normalized": []
},
{
"id": "NCT03168178_inc_T6",
"type": "Procedure",
"text": [
"labor management"
],
"offsets": [
[
74,
90
]
],
"normalized": []
},
{
"id": "NCT03168178_inc_T7",
"type": "Mood",
"text": [
"Admitted for"
],
"offsets": [
[
61,
73
]
],
"normalized": []
},
{
"id": "NCT03168178_inc_T8",
"type": "Measurement",
"text": [
"fever"
],
"offsets": [
[
104,
109
]
],
"normalized": []
},
{
"id": "NCT03168178_inc_T9",
"type": "Value",
"text": [
"100.4 F or greater"
],
"offsets": [
[
113,
131
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03168178_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03168178_inc_T4",
"arg2_id": "NCT03168178_inc_T3",
"normalized": []
},
{
"id": "NCT03168178_inc_R2",
"type": "Has_mood",
"arg1_id": "NCT03168178_inc_T6",
"arg2_id": "NCT03168178_inc_T7",
"normalized": []
},
{
"id": "NCT03168178_inc_R3",
"type": "Has_value",
"arg1_id": "NCT03168178_inc_T8",
"arg2_id": "NCT03168178_inc_T9",
"normalized": []
}
] |
NCT03168555_exc | NCT03168555 | [
{
"id": "NCT03168555_exc_text",
"type": "exclusion",
"text": [
"small bowel resection\nright sided hemicolectomy\nknown chronic diarrheal disease (celiac disease, lactose malabsorption, Inflammatory bowel diseases, incl microscopic colitis)\npregnancy\nwish for pregnancy within next three months\nallergy to eggs\nallergy to constituents in Xenbilox (capsules with chenodeoxycholic acid)\nacute cholecystitis within two months\nchronic cholecystitis\ncirrhosis of the liver\nsuspected obstructive choledocholithiasis\nicterus\n"
],
"offsets": [
[
0,
452
]
]
}
] | [
{
"id": "NCT03168555_exc_T1",
"type": "Procedure",
"text": [
"small bowel resection"
],
"offsets": [
[
0,
21
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T2",
"type": "Procedure",
"text": [
"right sided hemicolectomy"
],
"offsets": [
[
22,
47
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T3",
"type": "Condition",
"text": [
"chronic diarrheal disease"
],
"offsets": [
[
54,
79
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T4",
"type": "Condition",
"text": [
"celiac disease"
],
"offsets": [
[
81,
95
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T5",
"type": "Condition",
"text": [
"lactose malabsorption"
],
"offsets": [
[
97,
118
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T6",
"type": "Condition",
"text": [
"Inflammatory bowel diseases"
],
"offsets": [
[
120,
147
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T7",
"type": "Condition",
"text": [
"microscopic colitis"
],
"offsets": [
[
154,
173
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T8",
"type": "Scope",
"text": [
"celiac disease, lactose malabsorption, Inflammatory bowel diseases, incl microscopic colitis"
],
"offsets": [
[
81,
173
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T9",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
175,
184
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T10",
"type": "Temporal",
"text": [
"within next three months"
],
"offsets": [
[
204,
228
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T11",
"type": "Condition",
"text": [
"pregnancy"
],
"offsets": [
[
194,
203
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T12",
"type": "Mood",
"text": [
"wish for"
],
"offsets": [
[
185,
193
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T13",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
229,
236
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T14",
"type": "Drug",
"text": [
"eggs"
],
"offsets": [
[
240,
244
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T15",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
245,
252
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T16",
"type": "Drug",
"text": [
"constituents in Xenbilox"
],
"offsets": [
[
256,
280
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T17",
"type": "Drug",
"text": [
"chenodeoxycholic acid"
],
"offsets": [
[
296,
317
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T18",
"type": "Condition",
"text": [
"acute cholecystitis"
],
"offsets": [
[
319,
338
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T19",
"type": "Temporal",
"text": [
"within two months"
],
"offsets": [
[
339,
356
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T20",
"type": "Condition",
"text": [
"chronic cholecystitis"
],
"offsets": [
[
357,
378
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T21",
"type": "Condition",
"text": [
"cirrhosis of the liver"
],
"offsets": [
[
379,
401
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T22",
"type": "Mood",
"text": [
"suspected"
],
"offsets": [
[
402,
411
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T23",
"type": "Condition",
"text": [
"obstructive choledocholithiasis"
],
"offsets": [
[
412,
443
]
],
"normalized": []
},
{
"id": "NCT03168555_exc_T24",
"type": "Condition",
"text": [
"icterus"
],
"offsets": [
[
444,
451
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03168555_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT03168555_exc_T3",
"arg2_id": "NCT03168555_exc_T8",
"normalized": []
},
{
"id": "NCT03168555_exc_R2",
"type": "Has_mood",
"arg1_id": "NCT03168555_exc_T11",
"arg2_id": "NCT03168555_exc_T12",
"normalized": []
},
{
"id": "NCT03168555_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT03168555_exc_T11",
"arg2_id": "NCT03168555_exc_T10",
"normalized": []
},
{
"id": "NCT03168555_exc_R4",
"type": "AND",
"arg1_id": "NCT03168555_exc_T13",
"arg2_id": "NCT03168555_exc_T14",
"normalized": []
},
{
"id": "NCT03168555_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT03168555_exc_T16",
"arg2_id": "NCT03168555_exc_T17",
"normalized": []
},
{
"id": "NCT03168555_exc_R6",
"type": "AND",
"arg1_id": "NCT03168555_exc_T15",
"arg2_id": "NCT03168555_exc_T16",
"normalized": []
},
{
"id": "NCT03168555_exc_R7",
"type": "Has_temporal",
"arg1_id": "NCT03168555_exc_T18",
"arg2_id": "NCT03168555_exc_T19",
"normalized": []
},
{
"id": "NCT03168555_exc_R8",
"type": "Has_mood",
"arg1_id": "NCT03168555_exc_T23",
"arg2_id": "NCT03168555_exc_T22",
"normalized": []
}
] |
NCT03168555_inc | NCT03168555 | [
{
"id": "NCT03168555_inc_text",
"type": "inclusion",
"text": [
"planned elective cholecystectomy\n"
],
"offsets": [
[
0,
33
]
]
}
] | [
{
"id": "NCT03168555_inc_T1",
"type": "Mood",
"text": [
"planned"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "NCT03168555_inc_T2",
"type": "Qualifier",
"text": [
"elective"
],
"offsets": [
[
8,
16
]
],
"normalized": []
},
{
"id": "NCT03168555_inc_T3",
"type": "Condition",
"text": [
"cholecystectomy"
],
"offsets": [
[
17,
32
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03168555_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03168555_inc_T3",
"arg2_id": "NCT03168555_inc_T2",
"normalized": []
},
{
"id": "NCT03168555_inc_R2",
"type": "Has_mood",
"arg1_id": "NCT03168555_inc_T3",
"arg2_id": "NCT03168555_inc_T1",
"normalized": []
}
] |
NCT03169127_exc | NCT03169127 | [
{
"id": "NCT03169127_exc_text",
"type": "exclusion",
"text": [
"Presence of systemic diseases;\nPresence of local inflammation and/or infection;\nAny history of allergic reaction to local anesthetics, gastrointestinal bleeding or ulceration;\nCardiovascular, kidney or hepatic diseases;\nPatients who are making use of antidepressants, diuretics or anticoagulants;\nAsthma and allergy to aspirin, ibuprofen or any other nonsteroidal antiinflammatory drug;\nRegular use of any nonsteroidal antiinflammatory drug,\nPregnancy or breast feeding.\n"
],
"offsets": [
[
0,
471
]
]
}
] | [
{
"id": "NCT03169127_exc_T1",
"type": "Condition",
"text": [
"systemic diseases"
],
"offsets": [
[
12,
29
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T2",
"type": "Condition",
"text": [
"local inflammation"
],
"offsets": [
[
43,
61
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T3",
"type": "Condition",
"text": [
"ocal",
"nfection;"
],
"offsets": [
[
44,
48
],
[
70,
79
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T4",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
84,
91
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T5",
"type": "Condition",
"text": [
"allergic reaction"
],
"offsets": [
[
95,
112
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T6",
"type": "Drug",
"text": [
"local anesthetics"
],
"offsets": [
[
116,
133
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T7",
"type": "Condition",
"text": [
"gastrointestinal bleeding"
],
"offsets": [
[
135,
160
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T8",
"type": "Condition",
"text": [
"strointestinal b",
"ceration;"
],
"offsets": [
[
137,
153
],
[
166,
175
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T9",
"type": "Scope",
"text": [
"allergic reaction to local anesthetics, gastrointestinal bleeding or ulceration"
],
"offsets": [
[
95,
174
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T10",
"type": "Condition",
"text": [
"diovascular, k",
"eases;\nP"
],
"offsets": [
[
179,
193
],
[
213,
221
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T11",
"type": "Condition",
"text": [
"ney or",
"eases;\nP"
],
"offsets": [
[
195,
201
],
[
213,
221
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T12",
"type": "Condition",
"text": [
"hepatic diseases"
],
"offsets": [
[
202,
218
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T13",
"type": "Drug",
"text": [
"antidepressants"
],
"offsets": [
[
251,
266
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T14",
"type": "Drug",
"text": [
"diuretics"
],
"offsets": [
[
268,
277
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T15",
"type": "Drug",
"text": [
"anticoagulants"
],
"offsets": [
[
281,
295
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T16",
"type": "Condition",
"text": [
"Asthma"
],
"offsets": [
[
297,
303
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T17",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
308,
315
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T18",
"type": "Drug",
"text": [
"aspirin"
],
"offsets": [
[
319,
326
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T19",
"type": "Drug",
"text": [
"ibuprofen"
],
"offsets": [
[
328,
337
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T20",
"type": "Drug",
"text": [
"nonsteroidal antiinflammatory drug"
],
"offsets": [
[
351,
385
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T21",
"type": "Qualifier",
"text": [
"any other"
],
"offsets": [
[
341,
350
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T22",
"type": "Scope",
"text": [
"aspirin, ibuprofen or any other nonsteroidal antiinflammatory drug"
],
"offsets": [
[
319,
385
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T23",
"type": "Multiplier",
"text": [
"Regular use"
],
"offsets": [
[
387,
398
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T24",
"type": "Condition",
"text": [
"nonsteroidal antiinflammatory drug"
],
"offsets": [
[
406,
440
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T25",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
442,
451
]
],
"normalized": []
},
{
"id": "NCT03169127_exc_T26",
"type": "Observation",
"text": [
"breast feeding"
],
"offsets": [
[
455,
469
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03169127_exc_R1",
"type": "AND",
"arg1_id": "NCT03169127_exc_T5",
"arg2_id": "NCT03169127_exc_T6",
"normalized": []
},
{
"id": "NCT03169127_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT03169127_exc_T9",
"arg2_id": "NCT03169127_exc_T4",
"normalized": []
},
{
"id": "NCT03169127_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT03169127_exc_T20",
"arg2_id": "NCT03169127_exc_T21",
"normalized": []
},
{
"id": "NCT03169127_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT03169127_exc_T17",
"arg2_id": "NCT03169127_exc_T22",
"normalized": []
},
{
"id": "NCT03169127_exc_R5",
"type": "Has_multiplier",
"arg1_id": "NCT03169127_exc_T24",
"arg2_id": "NCT03169127_exc_T23",
"normalized": []
}
] |
NCT03169127_inc | NCT03169127 | [
{
"id": "NCT03169127_inc_text",
"type": "inclusion",
"text": [
"Need of lower third molar surgeries\n"
],
"offsets": [
[
0,
36
]
]
}
] | [
{
"id": "NCT03169127_inc_T1",
"type": "Procedure",
"text": [
"surgeries"
],
"offsets": [
[
26,
35
]
],
"normalized": []
},
{
"id": "NCT03169127_inc_T2",
"type": "Qualifier",
"text": [
"lower third molar"
],
"offsets": [
[
8,
25
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03169127_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03169127_inc_T1",
"arg2_id": "NCT03169127_inc_T2",
"normalized": []
}
] |
NCT03171987_exc | NCT03171987 | [
{
"id": "NCT03171987_exc_text",
"type": "exclusion",
"text": [
"Known or suspected serious spinal pathology and spinal implants\nLumbar spinal surgery within the preceding six months\nSerious comorbidities preventing prescription of paracetamol\nAlternative treatment for low back pain in previous two weeks\nChronic neurological lesion\nChronic musculoskeletal lesion\nActive cancer\nPregnancy\nUse of pain medication (except paracetamol) within 3 days\nTreatment site has active skin lesion or inflammation\nKnown allergy to skin patch\n"
],
"offsets": [
[
0,
464
]
]
}
] | [
{
"id": "NCT03171987_exc_T1",
"type": "Condition",
"text": [
"spinal pathology"
],
"offsets": [
[
27,
43
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T2",
"type": "Device",
"text": [
"spinal implants"
],
"offsets": [
[
48,
63
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T3",
"type": "Qualifier",
"text": [
"serious"
],
"offsets": [
[
19,
26
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T4",
"type": "Mood",
"text": [
"suspected"
],
"offsets": [
[
9,
18
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T5",
"type": "Mood",
"text": [
"Known"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T6",
"type": "Scope",
"text": [
"serious spinal pathology and spinal implants"
],
"offsets": [
[
19,
63
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T7",
"type": "Mood",
"text": [
"Known or suspected"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T8",
"type": "Procedure",
"text": [
"Lumbar spinal surgery"
],
"offsets": [
[
64,
85
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T9",
"type": "Temporal",
"text": [
"within the preceding six months"
],
"offsets": [
[
86,
117
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T10",
"type": "Qualifier",
"text": [
"Serious"
],
"offsets": [
[
118,
125
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T11",
"type": "Condition",
"text": [
"comorbidities"
],
"offsets": [
[
126,
139
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T12",
"type": "Condition",
"text": [
"preventing"
],
"offsets": [
[
140,
150
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T13",
"type": "Drug",
"text": [
"paracetamol"
],
"offsets": [
[
167,
178
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T14",
"type": "Qualifier",
"text": [
"Alternative"
],
"offsets": [
[
179,
190
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T15",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
191,
200
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T16",
"type": "Condition",
"text": [
"low back pain"
],
"offsets": [
[
205,
218
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T17",
"type": "Temporal",
"text": [
"in previous two weeks"
],
"offsets": [
[
219,
240
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T18",
"type": "Condition",
"text": [
"Chronic neurological lesion"
],
"offsets": [
[
241,
268
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T19",
"type": "Condition",
"text": [
"Chronic musculoskeletal lesion"
],
"offsets": [
[
269,
299
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T20",
"type": "Condition",
"text": [
"cancer"
],
"offsets": [
[
307,
313
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T21",
"type": "Qualifier",
"text": [
"Active"
],
"offsets": [
[
300,
306
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T22",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
314,
323
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T23",
"type": "Drug",
"text": [
"pain medication"
],
"offsets": [
[
331,
346
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T24",
"type": "Negation",
"text": [
"except"
],
"offsets": [
[
348,
354
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T25",
"type": "Drug",
"text": [
"paracetamol"
],
"offsets": [
[
355,
366
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T26",
"type": "Temporal",
"text": [
"within 3 days"
],
"offsets": [
[
368,
381
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T27",
"type": "Condition",
"text": [
"skin lesion"
],
"offsets": [
[
408,
419
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T28",
"type": "Condition",
"text": [
"inflammation"
],
"offsets": [
[
423,
435
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T29",
"type": "Qualifier",
"text": [
"active"
],
"offsets": [
[
401,
407
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T30",
"type": "Scope",
"text": [
"skin lesion or inflammation"
],
"offsets": [
[
408,
435
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T31",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
442,
449
]
],
"normalized": []
},
{
"id": "NCT03171987_exc_T32",
"type": "Device",
"text": [
"skin patch"
],
"offsets": [
[
453,
463
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03171987_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03171987_exc_T1",
"arg2_id": "NCT03171987_exc_T3",
"normalized": []
},
{
"id": "NCT03171987_exc_R2",
"type": "Has_mood",
"arg1_id": "NCT03171987_exc_T6",
"arg2_id": "NCT03171987_exc_T7",
"normalized": []
},
{
"id": "NCT03171987_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT03171987_exc_T8",
"arg2_id": "NCT03171987_exc_T9",
"normalized": []
},
{
"id": "NCT03171987_exc_R4",
"type": "AND",
"arg1_id": "NCT03171987_exc_T12",
"arg2_id": "NCT03171987_exc_T13",
"normalized": []
},
{
"id": "NCT03171987_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT03171987_exc_T11",
"arg2_id": "NCT03171987_exc_T10",
"normalized": []
},
{
"id": "NCT03171987_exc_R6",
"type": "AND",
"arg1_id": "NCT03171987_exc_T11",
"arg2_id": "NCT03171987_exc_T12",
"normalized": []
},
{
"id": "NCT03171987_exc_R7",
"type": "Has_temporal",
"arg1_id": "NCT03171987_exc_T16",
"arg2_id": "NCT03171987_exc_T17",
"normalized": []
},
{
"id": "NCT03171987_exc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT03171987_exc_T15",
"arg2_id": "NCT03171987_exc_T14",
"normalized": []
},
{
"id": "NCT03171987_exc_R9",
"type": "AND",
"arg1_id": "NCT03171987_exc_T15",
"arg2_id": "NCT03171987_exc_T16",
"normalized": []
},
{
"id": "NCT03171987_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT03171987_exc_T20",
"arg2_id": "NCT03171987_exc_T21",
"normalized": []
},
{
"id": "NCT03171987_exc_R11",
"type": "Has_negation",
"arg1_id": "NCT03171987_exc_T25",
"arg2_id": "NCT03171987_exc_T24",
"normalized": []
},
{
"id": "NCT03171987_exc_R12",
"type": "AND",
"arg1_id": "NCT03171987_exc_T23",
"arg2_id": "NCT03171987_exc_T25",
"normalized": []
},
{
"id": "NCT03171987_exc_R13",
"type": "Has_temporal",
"arg1_id": "NCT03171987_exc_T23",
"arg2_id": "NCT03171987_exc_T26",
"normalized": []
},
{
"id": "NCT03171987_exc_R14",
"type": "Has_qualifier",
"arg1_id": "NCT03171987_exc_T30",
"arg2_id": "NCT03171987_exc_T29",
"normalized": []
},
{
"id": "NCT03171987_exc_R15",
"type": "AND",
"arg1_id": "NCT03171987_exc_T31",
"arg2_id": "NCT03171987_exc_T32",
"normalized": []
}
] |
NCT03171987_inc | NCT03171987 | [
{
"id": "NCT03171987_inc_text",
"type": "inclusion",
"text": [
"All subjects underwent a detailed history and systemic physical examination including neurologic and musculoskeletal evaluations. To rule out any confounding etiologies, basic diagnostic laboratory tests including complete blood count and acute phase reactants (erythrocyte sedimentation rate and C-reactive protein) were performed. The patients diagnosed as having acute non-specific low back pain according to history and physical examinations were invited to participate and will be informed about the purpose and course of the study.\nA primary complaint of pain in the area between the 12th rib and buttock crease without leg pain\nFemale or male, 20 - 80 years of age\nLow back pain of less than six weeks' duration; and at least moderate pain intensity (NRS<U+2267>4)\n"
],
"offsets": [
[
0,
772
]
]
}
] | [
{
"id": "NCT03171987_inc_T1",
"type": "Qualifier",
"text": [
"acute"
],
"offsets": [
[
366,
371
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T2",
"type": "Condition",
"text": [
"non-specific low back pain"
],
"offsets": [
[
372,
398
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T3",
"type": "Procedure",
"text": [
"physical examinations"
],
"offsets": [
[
424,
445
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T4",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
412,
419
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T5",
"type": "Scope",
"text": [
"history and physical examinations"
],
"offsets": [
[
412,
445
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T7",
"type": "Procedure",
"text": [
"complete blood count"
],
"offsets": [
[
214,
234
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T8",
"type": "Procedure",
"text": [
"acute phase reactants"
],
"offsets": [
[
239,
260
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T9",
"type": "Procedure",
"text": [
"erythrocyte sedimentation rate"
],
"offsets": [
[
262,
292
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T10",
"type": "Procedure",
"text": [
"C-reactive protein"
],
"offsets": [
[
297,
315
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T11",
"type": "Scope",
"text": [
"erythrocyte sedimentation rate and C-reactive protein"
],
"offsets": [
[
262,
315
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T12",
"type": "Procedure",
"text": [
"diagnostic laboratory tests"
],
"offsets": [
[
176,
203
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T13",
"type": "Condition",
"text": [
"pain"
],
"offsets": [
[
561,
565
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T14",
"type": "Qualifier",
"text": [
"area between the 12th rib and buttock crease"
],
"offsets": [
[
573,
617
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T15",
"type": "Condition",
"text": [
"leg pain"
],
"offsets": [
[
626,
634
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T16",
"type": "Negation",
"text": [
"without"
],
"offsets": [
[
618,
625
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T17",
"type": "Person",
"text": [
"Female"
],
"offsets": [
[
635,
641
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T18",
"type": "Person",
"text": [
"male"
],
"offsets": [
[
645,
649
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T19",
"type": "Value",
"text": [
"20 - 80 years"
],
"offsets": [
[
651,
664
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T20",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
668,
671
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T21",
"type": "Condition",
"text": [
"Low back pain"
],
"offsets": [
[
672,
685
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T22",
"type": "Temporal",
"text": [
"less than six weeks' duration"
],
"offsets": [
[
689,
718
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T23",
"type": "Value",
"text": [
"at least moderate"
],
"offsets": [
[
724,
741
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T24",
"type": "Measurement",
"text": [
"pain intensity"
],
"offsets": [
[
742,
756
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T25",
"type": "Measurement",
"text": [
"NRS"
],
"offsets": [
[
758,
761
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T26",
"type": "Value",
"text": [
"4"
],
"offsets": [
[
769,
770
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T27",
"type": "Scope",
"text": [
"at least moderate pain intensity"
],
"offsets": [
[
724,
756
]
],
"normalized": []
},
{
"id": "NCT03171987_inc_T28",
"type": "Scope",
"text": [
"NRS<U+2267>4"
],
"offsets": [
[
758,
770
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03171987_inc_R1",
"type": "Has_scope",
"arg1_id": "NCT03171987_inc_T2",
"arg2_id": "NCT03171987_inc_T5",
"normalized": []
},
{
"id": "NCT03171987_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03171987_inc_T2",
"arg2_id": "NCT03171987_inc_T1",
"normalized": []
},
{
"id": "NCT03171987_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT03171987_inc_T8",
"arg2_id": "NCT03171987_inc_T11",
"normalized": []
},
{
"id": "NCT03171987_inc_R4",
"type": "Has_negation",
"arg1_id": "NCT03171987_inc_T15",
"arg2_id": "NCT03171987_inc_T16",
"normalized": []
},
{
"id": "NCT03171987_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT03171987_inc_T13",
"arg2_id": "NCT03171987_inc_T14",
"normalized": []
},
{
"id": "NCT03171987_inc_R6",
"type": "AND",
"arg1_id": "NCT03171987_inc_T13",
"arg2_id": "NCT03171987_inc_T15",
"normalized": []
},
{
"id": "NCT03171987_inc_R7",
"type": "Has_value",
"arg1_id": "NCT03171987_inc_T20",
"arg2_id": "NCT03171987_inc_T19",
"normalized": []
},
{
"id": "NCT03171987_inc_R8",
"type": "Has_temporal",
"arg1_id": "NCT03171987_inc_T21",
"arg2_id": "NCT03171987_inc_T22",
"normalized": []
},
{
"id": "NCT03171987_inc_R9",
"type": "Has_value",
"arg1_id": "NCT03171987_inc_T25",
"arg2_id": "NCT03171987_inc_T26",
"normalized": []
},
{
"id": "NCT03171987_inc_R10",
"type": "Has_value",
"arg1_id": "NCT03171987_inc_T24",
"arg2_id": "NCT03171987_inc_T23",
"normalized": []
},
{
"id": "NCT03171987_inc_R11",
"type": "Subsumes",
"arg1_id": "NCT03171987_inc_T27",
"arg2_id": "NCT03171987_inc_T28",
"normalized": []
}
] |
NCT03173092_exc | NCT03173092 | [
{
"id": "NCT03173092_exc_text",
"type": "exclusion",
"text": [
"Failure to have fully recovered (that is, less than or equal to [<=] Grade 1 toxicity) from the reversible effects of prior chemotherapy.\nMajor surgery within 14 days before enrollment.\nRadiotherapy within 14 days before enrollment (if the involved field is small, 7 days will be considered a sufficient interval between treatment and administration of the ixazomib.)\nCentral nervous system involvement.\nInfection requiring systemic antibiotic therapy or other serious infection within 14 days before study enrollment.\nEvidence of current uncontrolled cardiovascular conditions, including uncontrolled hypertension, uncontrolled cardiac arrhythmias, symptomatic congestive heart failure, unstable angina, or myocardial infarction within the past 6 months.\nSystemic treatment, within 14 days before the first dose of ixazomib, with strong cytochrome P450 3A (CYP3A) inducers (rifampin, rifapentine, rifabutin, carbamazepine, phenytoin, phenobarbital), or use of Ginkgo biloba or St. John's wort.\nOngoing or active systemic infection, active hepatitis B or C virus infection, or known human immunodeficiency virus positive.\nDiagnosed or treated for another malignancy within 2 years before study enrollment or previously diagnosed with another malignancy and have any evidence of residual disease. Participants with non-melanoma skin cancer or carcinoma in situ of any type are not excluded if they have undergone complete resection.\nHas greater than or equal to (>=) Grade 2 peripheral neuropathy, or Grade 1 with pain on clinical examination during the screening period.\nPD on first-line therapy.\nParticipation in other interventional clinical trials, including those with other investigational agents not included in this trial, within 30 days of the start of this trial and throughout the duration of this trial. Non-interventional trials (that is, observational trials) are permitted at any time point.\n"
],
"offsets": [
[
0,
1906
]
]
}
] | [
{
"id": "NCT03173092_exc_T1",
"type": "Negation",
"text": [
"Failure"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T2",
"type": "Condition",
"text": [
"fully recovered"
],
"offsets": [
[
16,
31
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T3",
"type": "Value",
"text": [
"less than or equal to [<=] Grade 1"
],
"offsets": [
[
42,
76
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T4",
"type": "Measurement",
"text": [
"toxicity"
],
"offsets": [
[
77,
85
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T5",
"type": "Procedure",
"text": [
"chemotherapy"
],
"offsets": [
[
124,
136
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T6",
"type": "Scope",
"text": [
"Failure to have fully recovered"
],
"offsets": [
[
0,
31
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T7",
"type": "Scope",
"text": [
"less than or equal to [<=] Grade 1 toxicity"
],
"offsets": [
[
42,
85
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T8",
"type": "Procedure",
"text": [
"Major surgery"
],
"offsets": [
[
138,
151
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T9",
"type": "Temporal",
"text": [
"within 14 days before enrollment"
],
"offsets": [
[
152,
184
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T10",
"type": "Procedure",
"text": [
"Radiotherapy"
],
"offsets": [
[
186,
198
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T11",
"type": "Temporal",
"text": [
"within 14 days before enrollment"
],
"offsets": [
[
199,
231
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T12",
"type": "Observation",
"text": [
"involved field is small"
],
"offsets": [
[
240,
263
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T13",
"type": "Temporal",
"text": [
"7 days"
],
"offsets": [
[
265,
271
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T14",
"type": "Scope",
"text": [
"thin 14 days before enrollment (",
"volved field is small, 7 days w"
],
"offsets": [
[
201,
233
],
[
242,
273
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T15",
"type": "Condition",
"text": [
"Central nervous system involvement"
],
"offsets": [
[
368,
402
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T16",
"type": "Condition",
"text": [
"Infection"
],
"offsets": [
[
404,
413
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T17",
"type": "Procedure",
"text": [
"systemic antibiotic therapy"
],
"offsets": [
[
424,
451
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T18",
"type": "Qualifier",
"text": [
"other"
],
"offsets": [
[
455,
460
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T19",
"type": "Qualifier",
"text": [
"serious"
],
"offsets": [
[
461,
468
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T20",
"type": "Condition",
"text": [
"infection"
],
"offsets": [
[
469,
478
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T21",
"type": "Temporal",
"text": [
"within 14 days before study enrollment"
],
"offsets": [
[
479,
517
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T22",
"type": "Condition",
"text": [
"cardiovascular conditions"
],
"offsets": [
[
552,
577
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T23",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
589,
601
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T24",
"type": "Condition",
"text": [
"hypertension"
],
"offsets": [
[
602,
614
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T25",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
616,
628
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T26",
"type": "Condition",
"text": [
"cardiac arrhythmias"
],
"offsets": [
[
629,
648
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T27",
"type": "Qualifier",
"text": [
"symptomatic"
],
"offsets": [
[
650,
661
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T28",
"type": "Condition",
"text": [
"congestive heart failure"
],
"offsets": [
[
662,
686
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T29",
"type": "Condition",
"text": [
"unstable angina"
],
"offsets": [
[
688,
703
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T30",
"type": "Condition",
"text": [
"myocardial infarction"
],
"offsets": [
[
708,
729
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T31",
"type": "Temporal",
"text": [
"within the past 6 months"
],
"offsets": [
[
730,
754
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T32",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
539,
551
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T33",
"type": "Temporal",
"text": [
"current"
],
"offsets": [
[
531,
538
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T34",
"type": "Scope",
"text": [
"uncontrolled hypertension, uncontrolled cardiac arrhythmias, symptomatic congestive heart failure, unstable angina, or myocardial infarction within the past 6 months"
],
"offsets": [
[
589,
754
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T35",
"type": "Scope",
"text": [
"current uncontrolled cardiovascular conditions"
],
"offsets": [
[
531,
577
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T36",
"type": "Procedure",
"text": [
"Systemic treatment"
],
"offsets": [
[
756,
774
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T37",
"type": "Temporal",
"text": [
"within 14 days before the first dose of ixazomib"
],
"offsets": [
[
776,
824
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T38",
"type": "Reference_point",
"text": [
"the first dose of ixazomib"
],
"offsets": [
[
798,
824
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T39",
"type": "Drug",
"text": [
"ixazomib"
],
"offsets": [
[
816,
824
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T40",
"type": "Drug",
"text": [
"strong cytochrome P450 3A (CYP3A) inducers"
],
"offsets": [
[
831,
873
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T41",
"type": "Drug",
"text": [
"rifampin"
],
"offsets": [
[
875,
883
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T42",
"type": "Drug",
"text": [
"rifapentine"
],
"offsets": [
[
885,
896
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T43",
"type": "Drug",
"text": [
"rifabutin"
],
"offsets": [
[
898,
907
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T44",
"type": "Drug",
"text": [
"carbamazepine"
],
"offsets": [
[
909,
922
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T45",
"type": "Drug",
"text": [
"phenytoin"
],
"offsets": [
[
924,
933
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T46",
"type": "Drug",
"text": [
"phenobarbital"
],
"offsets": [
[
935,
948
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T47",
"type": "Scope",
"text": [
"rifampin, rifapentine, rifabutin, carbamazepine, phenytoin, phenobarbital"
],
"offsets": [
[
875,
948
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T48",
"type": "Drug",
"text": [
"Ginkgo biloba"
],
"offsets": [
[
961,
974
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T49",
"type": "Drug",
"text": [
"St. John's wort"
],
"offsets": [
[
978,
993
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T50",
"type": "Scope",
"text": [
"strong cytochrome P450 3A (CYP3A) inducers (rifampin, rifapentine, rifabutin, carbamazepine, phenytoin, phenobarbital), or use of Ginkgo biloba or St. John's wort"
],
"offsets": [
[
831,
993
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T51",
"type": "Qualifier",
"text": [
"active"
],
"offsets": [
[
1006,
1012
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T52",
"type": "Temporal",
"text": [
"Ongoing"
],
"offsets": [
[
995,
1002
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T53",
"type": "Condition",
"text": [
"systemic infection"
],
"offsets": [
[
1013,
1031
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T54",
"type": "Qualifier",
"text": [
"active"
],
"offsets": [
[
1033,
1039
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T55",
"type": "Condition",
"text": [
"is B or C v",
"nfection, or kn"
],
"offsets": [
[
1047,
1058
],
[
1064,
1079
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T56",
"type": "Condition",
"text": [
"C virus infection"
],
"offsets": [
[
1055,
1072
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T57",
"type": "Scope",
"text": [
"hepatitis B or C virus infection"
],
"offsets": [
[
1040,
1072
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T58",
"type": "Scope",
"text": [
"Ongoing or active"
],
"offsets": [
[
995,
1012
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T59",
"type": "Measurement",
"text": [
"human immunodeficiency virus"
],
"offsets": [
[
1083,
1111
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T60",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
1112,
1120
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T61",
"type": "Condition",
"text": [
"malignancy"
],
"offsets": [
[
1155,
1165
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T62",
"type": "Temporal",
"text": [
"within 2 years before study enrollment"
],
"offsets": [
[
1166,
1204
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T63",
"type": "Temporal",
"text": [
"previously"
],
"offsets": [
[
1208,
1218
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T64",
"type": "Qualifier",
"text": [
"another"
],
"offsets": [
[
1234,
1241
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T65",
"type": "Condition",
"text": [
"malignancy"
],
"offsets": [
[
1242,
1252
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T66",
"type": "Condition",
"text": [
"residual disease"
],
"offsets": [
[
1278,
1294
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T67",
"type": "Mood",
"text": [
"any evidence of"
],
"offsets": [
[
1262,
1277
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T68",
"type": "Condition",
"text": [
"non-melanoma skin cancer"
],
"offsets": [
[
1314,
1338
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T69",
"type": "Condition",
"text": [
"carcinoma in situ"
],
"offsets": [
[
1342,
1359
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T70",
"type": "Qualifier",
"text": [
"any type"
],
"offsets": [
[
1363,
1371
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T71",
"type": "Negation",
"text": [
"not excluded"
],
"offsets": [
[
1376,
1388
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T72",
"type": "Procedure",
"text": [
"complete resection"
],
"offsets": [
[
1412,
1430
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T73",
"type": "Scope",
"text": [
"non-melanoma skin cancer or carcinoma in situ of any type"
],
"offsets": [
[
1314,
1371
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T74",
"type": "Qualifier",
"text": [
"greater than or equal to (>=) Grade 2"
],
"offsets": [
[
1436,
1473
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T75",
"type": "Condition",
"text": [
"peripheral neuropathy"
],
"offsets": [
[
1474,
1495
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T76",
"type": "Qualifier",
"text": [
"Grade 1"
],
"offsets": [
[
1500,
1507
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T77",
"type": "Condition",
"text": [
"pain"
],
"offsets": [
[
1513,
1517
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T78",
"type": "Scope",
"text": [
"Grade 1 with pain"
],
"offsets": [
[
1500,
1517
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T79",
"type": "Scope",
"text": [
"greater than or equal to (>=) Grade 2 peripheral neuropathy"
],
"offsets": [
[
1436,
1495
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T80",
"type": "Drug",
"text": [
"PD"
],
"offsets": [
[
1571,
1573
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T81",
"type": "Qualifier",
"text": [
"first-line therapy"
],
"offsets": [
[
1577,
1595
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T83",
"type": "Temporal",
"text": [
"within 30 days of the start of this trial"
],
"offsets": [
[
1730,
1771
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T84",
"type": "Temporal",
"text": [
"throughout the duration of this trial"
],
"offsets": [
[
1776,
1813
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T85",
"type": "Reference_point",
"text": [
"the start of this trial"
],
"offsets": [
[
1748,
1771
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T86",
"type": "Reference_point",
"text": [
"the duration of this trial"
],
"offsets": [
[
1787,
1813
]
],
"normalized": []
},
{
"id": "NCT03173092_exc_T87",
"type": "Scope",
"text": [
"within 30 days of the start of this trial and throughout the duration of this trial"
],
"offsets": [
[
1730,
1813
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03173092_exc_R1",
"type": "Has_negation",
"arg1_id": "NCT03173092_exc_T2",
"arg2_id": "NCT03173092_exc_T1",
"normalized": []
},
{
"id": "NCT03173092_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03173092_exc_T4",
"arg2_id": "NCT03173092_exc_T3",
"normalized": []
},
{
"id": "NCT03173092_exc_R3",
"type": "Subsumes",
"arg1_id": "NCT03173092_exc_T6",
"arg2_id": "NCT03173092_exc_T7",
"normalized": []
},
{
"id": "NCT03173092_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT03173092_exc_T5",
"arg2_id": "NCT03173092_exc_T6",
"normalized": []
},
{
"id": "NCT03173092_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT03173092_exc_T8",
"arg2_id": "NCT03173092_exc_T9",
"normalized": []
},
{
"id": "NCT03173092_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT03173092_exc_T12",
"arg2_id": "NCT03173092_exc_T13",
"normalized": []
},
{
"id": "NCT03173092_exc_R7",
"type": "Has_scope",
"arg1_id": "NCT03173092_exc_T10",
"arg2_id": "NCT03173092_exc_T14",
"normalized": []
},
{
"id": "NCT03173092_exc_R8",
"type": "Has_temporal",
"arg1_id": "NCT03173092_exc_T20",
"arg2_id": "NCT03173092_exc_T21",
"normalized": []
},
{
"id": "NCT03173092_exc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT03173092_exc_T20",
"arg2_id": "NCT03173092_exc_T19",
"normalized": []
},
{
"id": "NCT03173092_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT03173092_exc_T20",
"arg2_id": "NCT03173092_exc_T18",
"normalized": []
},
{
"id": "NCT03173092_exc_R11",
"type": "AND",
"arg1_id": "NCT03173092_exc_T16",
"arg2_id": "NCT03173092_exc_T17",
"normalized": []
},
{
"id": "NCT03173092_exc_R12",
"type": "Has_temporal",
"arg1_id": "NCT03173092_exc_T30",
"arg2_id": "NCT03173092_exc_T31",
"normalized": []
},
{
"id": "NCT03173092_exc_R13",
"type": "Has_qualifier",
"arg1_id": "NCT03173092_exc_T24",
"arg2_id": "NCT03173092_exc_T23",
"normalized": []
},
{
"id": "NCT03173092_exc_R14",
"type": "Has_qualifier",
"arg1_id": "NCT03173092_exc_T26",
"arg2_id": "NCT03173092_exc_T25",
"normalized": []
},
{
"id": "NCT03173092_exc_R15",
"type": "Has_qualifier",
"arg1_id": "NCT03173092_exc_T28",
"arg2_id": "NCT03173092_exc_T27",
"normalized": []
},
{
"id": "NCT03173092_exc_R16",
"type": "Has_qualifier",
"arg1_id": "NCT03173092_exc_T22",
"arg2_id": "NCT03173092_exc_T32",
"normalized": []
},
{
"id": "NCT03173092_exc_R17",
"type": "Has_temporal",
"arg1_id": "NCT03173092_exc_T22",
"arg2_id": "NCT03173092_exc_T33",
"normalized": []
},
{
"id": "NCT03173092_exc_R18",
"type": "Subsumes",
"arg1_id": "NCT03173092_exc_T35",
"arg2_id": "NCT03173092_exc_T34",
"normalized": []
},
{
"id": "NCT03173092_exc_R19",
"type": "Has_index",
"arg1_id": "NCT03173092_exc_T37",
"arg2_id": "NCT03173092_exc_T38",
"normalized": []
},
{
"id": "NCT03173092_exc_R21",
"type": "Has_temporal",
"arg1_id": "NCT03173092_exc_T36",
"arg2_id": "NCT03173092_exc_T37",
"normalized": []
},
{
"id": "NCT03173092_exc_R22",
"type": "Subsumes",
"arg1_id": "NCT03173092_exc_T40",
"arg2_id": "NCT03173092_exc_T47",
"normalized": []
},
{
"id": "NCT03173092_exc_R23",
"type": "Has_scope",
"arg1_id": "NCT03173092_exc_T36",
"arg2_id": "NCT03173092_exc_T50",
"normalized": []
},
{
"id": "NCT03173092_exc_R24",
"type": "Has_qualifier",
"arg1_id": "NCT03173092_exc_T57",
"arg2_id": "NCT03173092_exc_T54",
"normalized": []
},
{
"id": "NCT03173092_exc_R25",
"type": "Has_scope",
"arg1_id": "NCT03173092_exc_T53",
"arg2_id": "NCT03173092_exc_T58",
"normalized": []
},
{
"id": "NCT03173092_exc_R26",
"type": "Has_value",
"arg1_id": "NCT03173092_exc_T59",
"arg2_id": "NCT03173092_exc_T60",
"normalized": []
},
{
"id": "NCT03173092_exc_R27",
"type": "Has_qualifier",
"arg1_id": "NCT03173092_exc_T65",
"arg2_id": "NCT03173092_exc_T64",
"normalized": []
},
{
"id": "NCT03173092_exc_R28",
"type": "Has_temporal",
"arg1_id": "NCT03173092_exc_T61",
"arg2_id": "NCT03173092_exc_T62",
"normalized": []
},
{
"id": "NCT03173092_exc_R29",
"type": "Has_temporal",
"arg1_id": "NCT03173092_exc_T65",
"arg2_id": "NCT03173092_exc_T63",
"normalized": []
},
{
"id": "NCT03173092_exc_R30",
"type": "Has_mood",
"arg1_id": "NCT03173092_exc_T66",
"arg2_id": "NCT03173092_exc_T67",
"normalized": []
},
{
"id": "NCT03173092_exc_R31",
"type": "Has_qualifier",
"arg1_id": "NCT03173092_exc_T69",
"arg2_id": "NCT03173092_exc_T70",
"normalized": []
},
{
"id": "NCT03173092_exc_R32",
"type": "Has_negation",
"arg1_id": "NCT03173092_exc_T72",
"arg2_id": "NCT03173092_exc_T71",
"normalized": []
},
{
"id": "NCT03173092_exc_R33",
"type": "AND",
"arg1_id": "NCT03173092_exc_T73",
"arg2_id": "NCT03173092_exc_T72",
"normalized": []
},
{
"id": "NCT03173092_exc_R34",
"type": "Has_qualifier",
"arg1_id": "NCT03173092_exc_T75",
"arg2_id": "NCT03173092_exc_T74",
"normalized": []
},
{
"id": "NCT03173092_exc_R35",
"type": "Has_qualifier",
"arg1_id": "NCT03173092_exc_T80",
"arg2_id": "NCT03173092_exc_T81",
"normalized": []
},
{
"id": "NCT03173092_exc_R36",
"type": "Has_index",
"arg1_id": "NCT03173092_exc_T83",
"arg2_id": "NCT03173092_exc_T85",
"normalized": []
},
{
"id": "NCT03173092_exc_R37",
"type": "Has_index",
"arg1_id": "NCT03173092_exc_T84",
"arg2_id": "NCT03173092_exc_T86",
"normalized": []
}
] |
NCT03173092_inc | NCT03173092 | [
{
"id": "NCT03173092_inc_text",
"type": "inclusion",
"text": [
"Participants must have completed 3 cycles of a bortezomib-based induction regimen (as defined by current NCCN guidelines) and have no evidence of disease progression as defined by IMWG criteria.\nParticipants with light chain and free light chain (FLC) only may be enrolled if they meet all the criteria for a diagnosis of MM.\nParticipants must be considered by their physician eligible to receiving the IRD regimen.\nEastern Cooperative Oncology Group (ECOG) performance status and/or other performance status 0, 1, or 2 at time of enrollment.\n"
],
"offsets": [
[
0,
543
]
]
}
] | [
{
"id": "NCT03173092_inc_T1",
"type": "Multiplier",
"text": [
"3 cycles"
],
"offsets": [
[
33,
41
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T2",
"type": "Drug",
"text": [
"bortezomib"
],
"offsets": [
[
47,
57
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T3",
"type": "Procedure",
"text": [
"induction regimen"
],
"offsets": [
[
64,
81
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T4",
"type": "Qualifier",
"text": [
"NCCN guidelines"
],
"offsets": [
[
105,
120
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T5",
"type": "Value",
"text": [
"no evidence of disease progression"
],
"offsets": [
[
131,
165
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T6",
"type": "Measurement",
"text": [
"IMWG criteria"
],
"offsets": [
[
180,
193
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T7",
"type": "Measurement",
"text": [
"criteria for a diagnosis of MM"
],
"offsets": [
[
294,
324
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T8",
"type": "Value",
"text": [
"all"
],
"offsets": [
[
286,
289
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T9",
"type": "Condition",
"text": [
"light chain and free light chain (FLC)"
],
"offsets": [
[
213,
251
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T10",
"type": "Mood",
"text": [
"eligible to"
],
"offsets": [
[
377,
388
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T11",
"type": "Procedure",
"text": [
"IRD regimen"
],
"offsets": [
[
403,
414
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T12",
"type": "Measurement",
"text": [
"Eastern Cooperative Oncology Group (ECOG) performance status"
],
"offsets": [
[
416,
476
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T13",
"type": "Value",
"text": [
"0, 1, or 2"
],
"offsets": [
[
509,
519
]
],
"normalized": []
},
{
"id": "NCT03173092_inc_T14",
"type": "Temporal",
"text": [
"at time of enrollment"
],
"offsets": [
[
520,
541
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03173092_inc_R1",
"type": "AND",
"arg1_id": "NCT03173092_inc_T3",
"arg2_id": "NCT03173092_inc_T2",
"normalized": []
},
{
"id": "NCT03173092_inc_R2",
"type": "Has_multiplier",
"arg1_id": "NCT03173092_inc_T3",
"arg2_id": "NCT03173092_inc_T1",
"normalized": []
},
{
"id": "NCT03173092_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT03173092_inc_T3",
"arg2_id": "NCT03173092_inc_T4",
"normalized": []
},
{
"id": "NCT03173092_inc_R4",
"type": "Has_value",
"arg1_id": "NCT03173092_inc_T6",
"arg2_id": "NCT03173092_inc_T5",
"normalized": []
},
{
"id": "NCT03173092_inc_R5",
"type": "Has_value",
"arg1_id": "NCT03173092_inc_T7",
"arg2_id": "NCT03173092_inc_T8",
"normalized": []
},
{
"id": "NCT03173092_inc_R6",
"type": "AND",
"arg1_id": "NCT03173092_inc_T9",
"arg2_id": "NCT03173092_inc_T7",
"normalized": []
},
{
"id": "NCT03173092_inc_R7",
"type": "Has_mood",
"arg1_id": "NCT03173092_inc_T11",
"arg2_id": "NCT03173092_inc_T10",
"normalized": []
},
{
"id": "NCT03173092_inc_R8",
"type": "Has_value",
"arg1_id": "NCT03173092_inc_T12",
"arg2_id": "NCT03173092_inc_T13",
"normalized": []
},
{
"id": "NCT03173092_inc_R9",
"type": "Has_temporal",
"arg1_id": "NCT03173092_inc_T12",
"arg2_id": "NCT03173092_inc_T14",
"normalized": []
}
] |
NCT03176316_exc | NCT03176316 | [
{
"id": "NCT03176316_exc_text",
"type": "exclusion",
"text": [
"Pregnancy, age < 18, nursing, or documented allergy to naloxone\n"
],
"offsets": [
[
0,
64
]
]
}
] | [
{
"id": "NCT03176316_exc_T1",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT03176316_exc_T2",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
11,
14
]
],
"normalized": []
},
{
"id": "NCT03176316_exc_T3",
"type": "Value",
"text": [
"< 18"
],
"offsets": [
[
15,
19
]
],
"normalized": []
},
{
"id": "NCT03176316_exc_T4",
"type": "Condition",
"text": [
"nursing"
],
"offsets": [
[
21,
28
]
],
"normalized": []
},
{
"id": "NCT03176316_exc_T5",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
44,
51
]
],
"normalized": []
},
{
"id": "NCT03176316_exc_T6",
"type": "Drug",
"text": [
"naloxone"
],
"offsets": [
[
55,
63
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03176316_exc_R1",
"type": "AND",
"arg1_id": "NCT03176316_exc_T5",
"arg2_id": "NCT03176316_exc_T6",
"normalized": []
},
{
"id": "NCT03176316_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03176316_exc_T2",
"arg2_id": "NCT03176316_exc_T3",
"normalized": []
}
] |
NCT03176316_inc | NCT03176316 | [
{
"id": "NCT03176316_inc_text",
"type": "inclusion",
"text": [
"Patients will be included if they are having an in-patient spinal fusion procedure, are 18 years or older, post and post-operative pain control plan includes opioid medications.\n"
],
"offsets": [
[
0,
178
]
]
}
] | [
{
"id": "NCT03176316_inc_T1",
"type": "Visit",
"text": [
"in-patient"
],
"offsets": [
[
48,
58
]
],
"normalized": []
},
{
"id": "NCT03176316_inc_T2",
"type": "Procedure",
"text": [
"spinal fusion procedure"
],
"offsets": [
[
59,
82
]
],
"normalized": []
},
{
"id": "NCT03176316_inc_T3",
"type": "Value",
"text": [
"18 years or older"
],
"offsets": [
[
88,
105
]
],
"normalized": []
},
{
"id": "NCT03176316_inc_T4",
"type": "Person",
"text": [
"years"
],
"offsets": [
[
91,
96
]
],
"normalized": []
},
{
"id": "NCT03176316_inc_T5",
"type": "Temporal",
"text": [
"post-operative"
],
"offsets": [
[
116,
130
]
],
"normalized": []
},
{
"id": "NCT03176316_inc_T6",
"type": "Procedure",
"text": [
"pain control plan"
],
"offsets": [
[
131,
148
]
],
"normalized": []
},
{
"id": "NCT03176316_inc_T7",
"type": "Drug",
"text": [
"opioid"
],
"offsets": [
[
158,
164
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03176316_inc_R1",
"type": "AND",
"arg1_id": "NCT03176316_inc_T2",
"arg2_id": "NCT03176316_inc_T1",
"normalized": []
},
{
"id": "NCT03176316_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03176316_inc_T4",
"arg2_id": "NCT03176316_inc_T3",
"normalized": []
},
{
"id": "NCT03176316_inc_R3",
"type": "AND",
"arg1_id": "NCT03176316_inc_T6",
"arg2_id": "NCT03176316_inc_T7",
"normalized": []
},
{
"id": "NCT03176316_inc_R4",
"type": "Has_temporal",
"arg1_id": "NCT03176316_inc_T6",
"arg2_id": "NCT03176316_inc_T5",
"normalized": []
}
] |
NCT03177811_exc | NCT03177811 | [
{
"id": "NCT03177811_exc_text",
"type": "exclusion",
"text": [
"COPD exacerbation, very severe COPD with hypoxemia at low altitude (FEV1/FVC <0.7, FEV1 <40% predicted, oxygen saturation on room air <92% at 750 m).\nComorbidities such as uncontrolled cardiovascular disease, i.e., unstable systemic arterial hypertension, coronary artery disease; previous stroke; OSA; pneumothorax in the last 2 months.\nInternal, neurologic, rheumatologic or psychiatric disease including current heavy smoking (>20 cigarettes per day)\nKnown renal failure or allergy to acetazolamide and other sulfonamides\n"
],
"offsets": [
[
0,
525
]
]
}
] | [
{
"id": "NCT03177811_exc_T1",
"type": "Condition",
"text": [
"COPD exacerbation"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T2",
"type": "Condition",
"text": [
"COPD"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T3",
"type": "Qualifier",
"text": [
"very severe"
],
"offsets": [
[
19,
30
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T4",
"type": "Condition",
"text": [
"hypoxemia"
],
"offsets": [
[
41,
50
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T5",
"type": "Qualifier",
"text": [
"low altitude"
],
"offsets": [
[
54,
66
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T6",
"type": "Measurement",
"text": [
"FEV1/FVC"
],
"offsets": [
[
68,
76
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T7",
"type": "Value",
"text": [
"<0.7"
],
"offsets": [
[
77,
81
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T8",
"type": "Measurement",
"text": [
"FEV1"
],
"offsets": [
[
83,
87
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T9",
"type": "Value",
"text": [
"<40% predicted"
],
"offsets": [
[
88,
102
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T10",
"type": "Measurement",
"text": [
"oxygen saturation"
],
"offsets": [
[
104,
121
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T11",
"type": "Qualifier",
"text": [
"room air"
],
"offsets": [
[
125,
133
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T12",
"type": "Value",
"text": [
"<92% at 750 m"
],
"offsets": [
[
134,
147
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T13",
"type": "Scope",
"text": [
"FEV1/FVC <0.7, FEV1 <40% predicted, oxygen saturation on room air <92% at 750 m"
],
"offsets": [
[
68,
147
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T14",
"type": "Condition",
"text": [
"Comorbidities"
],
"offsets": [
[
150,
163
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T15",
"type": "Condition",
"text": [
"cardiovascular disease"
],
"offsets": [
[
185,
207
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T16",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
172,
184
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T17",
"type": "Condition",
"text": [
"systemic arterial hypertension"
],
"offsets": [
[
224,
254
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T18",
"type": "Qualifier",
"text": [
"unstable"
],
"offsets": [
[
215,
223
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T19",
"type": "Condition",
"text": [
"coronary artery disease"
],
"offsets": [
[
256,
279
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T20",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
290,
296
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T21",
"type": "Qualifier",
"text": [
"previous"
],
"offsets": [
[
281,
289
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T22",
"type": "Condition",
"text": [
"OSA"
],
"offsets": [
[
298,
301
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T23",
"type": "Condition",
"text": [
"pneumothorax"
],
"offsets": [
[
303,
315
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T24",
"type": "Temporal",
"text": [
"in the last 2 months"
],
"offsets": [
[
316,
336
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T25",
"type": "Scope",
"text": [
"unstable systemic arterial hypertension, coronary artery disease"
],
"offsets": [
[
215,
279
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T26",
"type": "Scope",
"text": [
"uncontrolled cardiovascular disease, i.e., unstable systemic arterial hypertension, coronary artery disease; previous stroke; OSA; pneumothorax in the last 2 months"
],
"offsets": [
[
172,
336
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T27",
"type": "Condition",
"text": [
"psychiatric disease"
],
"offsets": [
[
377,
396
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T28",
"type": "Condition",
"text": [
"eumatologic o",
"sease i"
],
"offsets": [
[
362,
375
],
[
391,
398
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T29",
"type": "Condition",
"text": [
"urologic,",
"sease i"
],
"offsets": [
[
350,
359
],
[
391,
398
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T30",
"type": "Condition",
"text": [
"ternal,",
"sease i"
],
"offsets": [
[
340,
347
],
[
391,
398
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T31",
"type": "Observation",
"text": [
"heavy smoking"
],
"offsets": [
[
415,
428
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T32",
"type": "Multiplier",
"text": [
">20 cigarettes per day"
],
"offsets": [
[
430,
452
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T33",
"type": "Condition",
"text": [
"renal failure"
],
"offsets": [
[
460,
473
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T34",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
477,
484
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T35",
"type": "Drug",
"text": [
"acetazolamide"
],
"offsets": [
[
488,
501
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T36",
"type": "Drug",
"text": [
"sulfonamides"
],
"offsets": [
[
512,
524
]
],
"normalized": []
},
{
"id": "NCT03177811_exc_T37",
"type": "Scope",
"text": [
"acetazolamide and other sulfonamides"
],
"offsets": [
[
488,
524
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03177811_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03177811_exc_T2",
"arg2_id": "NCT03177811_exc_T3",
"normalized": []
},
{
"id": "NCT03177811_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03177811_exc_T4",
"arg2_id": "NCT03177811_exc_T5",
"normalized": []
},
{
"id": "NCT03177811_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT03177811_exc_T10",
"arg2_id": "NCT03177811_exc_T11",
"normalized": []
},
{
"id": "NCT03177811_exc_R4",
"type": "Has_value",
"arg1_id": "NCT03177811_exc_T10",
"arg2_id": "NCT03177811_exc_T12",
"normalized": []
},
{
"id": "NCT03177811_exc_R5",
"type": "Has_value",
"arg1_id": "NCT03177811_exc_T8",
"arg2_id": "NCT03177811_exc_T9",
"normalized": []
},
{
"id": "NCT03177811_exc_R6",
"type": "Has_value",
"arg1_id": "NCT03177811_exc_T6",
"arg2_id": "NCT03177811_exc_T7",
"normalized": []
},
{
"id": "NCT03177811_exc_R7",
"type": "Has_scope",
"arg1_id": "NCT03177811_exc_T4",
"arg2_id": "NCT03177811_exc_T13",
"normalized": []
},
{
"id": "NCT03177811_exc_R8",
"type": "AND",
"arg1_id": "NCT03177811_exc_T2",
"arg2_id": "NCT03177811_exc_T4",
"normalized": []
},
{
"id": "NCT03177811_exc_R9",
"type": "AND",
"arg1_id": "NCT03177811_exc_T1",
"arg2_id": "NCT03177811_exc_T2",
"normalized": []
},
{
"id": "NCT03177811_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT03177811_exc_T15",
"arg2_id": "NCT03177811_exc_T16",
"normalized": []
},
{
"id": "NCT03177811_exc_R11",
"type": "Has_qualifier",
"arg1_id": "NCT03177811_exc_T20",
"arg2_id": "NCT03177811_exc_T21",
"normalized": []
},
{
"id": "NCT03177811_exc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT03177811_exc_T17",
"arg2_id": "NCT03177811_exc_T18",
"normalized": []
},
{
"id": "NCT03177811_exc_R13",
"type": "Has_scope",
"arg1_id": "NCT03177811_exc_T15",
"arg2_id": "NCT03177811_exc_T25",
"normalized": []
},
{
"id": "NCT03177811_exc_R14",
"type": "Has_temporal",
"arg1_id": "NCT03177811_exc_T23",
"arg2_id": "NCT03177811_exc_T24",
"normalized": []
},
{
"id": "NCT03177811_exc_R15",
"type": "Subsumes",
"arg1_id": "NCT03177811_exc_T14",
"arg2_id": "NCT03177811_exc_T26",
"normalized": []
},
{
"id": "NCT03177811_exc_R16",
"type": "Has_multiplier",
"arg1_id": "NCT03177811_exc_T31",
"arg2_id": "NCT03177811_exc_T32",
"normalized": []
},
{
"id": "NCT03177811_exc_R17",
"type": "Has_scope",
"arg1_id": "NCT03177811_exc_T34",
"arg2_id": "NCT03177811_exc_T37",
"normalized": []
}
] |
NCT03177811_inc | NCT03177811 | [
{
"id": "NCT03177811_inc_text",
"type": "inclusion",
"text": [
"Male and female patients, age 18-75 yrs.\nCOPD diagnosed according to GOLD, FEV1 40-80% predicted, SpO2 =92% at 750 m.\nBorn, raised and currently living at low altitude (<800m).\nWritten informed consent.\n"
],
"offsets": [
[
0,
203
]
]
}
] | [
{
"id": "NCT03177811_inc_T1",
"type": "Person",
"text": [
"Male"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT03177811_inc_T2",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
9,
15
]
],
"normalized": []
},
{
"id": "NCT03177811_inc_T3",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
26,
29
]
],
"normalized": []
},
{
"id": "NCT03177811_inc_T4",
"type": "Value",
"text": [
"18-75 yrs"
],
"offsets": [
[
30,
39
]
],
"normalized": []
},
{
"id": "NCT03177811_inc_T5",
"type": "Condition",
"text": [
"COPD"
],
"offsets": [
[
41,
45
]
],
"normalized": []
},
{
"id": "NCT03177811_inc_T6",
"type": "Measurement",
"text": [
"GOLD"
],
"offsets": [
[
69,
73
]
],
"normalized": []
},
{
"id": "NCT03177811_inc_T7",
"type": "Measurement",
"text": [
"FEV1"
],
"offsets": [
[
75,
79
]
],
"normalized": []
},
{
"id": "NCT03177811_inc_T8",
"type": "Value",
"text": [
"40-80% predicted"
],
"offsets": [
[
80,
96
]
],
"normalized": []
},
{
"id": "NCT03177811_inc_T9",
"type": "Measurement",
"text": [
"SpO2"
],
"offsets": [
[
98,
102
]
],
"normalized": []
},
{
"id": "NCT03177811_inc_T10",
"type": "Value",
"text": [
"=92% at 750 m"
],
"offsets": [
[
103,
116
]
],
"normalized": []
},
{
"id": "NCT03177811_inc_T11",
"type": "Scope",
"text": [
"FEV1 40-80% predicted, SpO2 =92% at 750 m"
],
"offsets": [
[
75,
116
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03177811_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03177811_inc_T3",
"arg2_id": "NCT03177811_inc_T4",
"normalized": []
},
{
"id": "NCT03177811_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03177811_inc_T7",
"arg2_id": "NCT03177811_inc_T8",
"normalized": []
},
{
"id": "NCT03177811_inc_R3",
"type": "Has_value",
"arg1_id": "NCT03177811_inc_T9",
"arg2_id": "NCT03177811_inc_T10",
"normalized": []
},
{
"id": "NCT03177811_inc_R4",
"type": "Has_scope",
"arg1_id": "NCT03177811_inc_T6",
"arg2_id": "NCT03177811_inc_T11",
"normalized": []
},
{
"id": "NCT03177811_inc_R5",
"type": "AND",
"arg1_id": "NCT03177811_inc_T6",
"arg2_id": "NCT03177811_inc_T5",
"normalized": []
}
] |
NCT03177837_exc | NCT03177837 | [
{
"id": "NCT03177837_exc_text",
"type": "exclusion",
"text": [
"COPD exacerbation, very severe COPD with hypoxemia at low altitude (FEV1/FVC <0.7, FEV1 <40% predicted, oxygen saturation on room air <92% at 750 m).\nComorbidities such as uncontrolled cardiovascular disease, i.e., unstable systemic arterial hypertension, coronary artery disease; previous stroke; OSA; pneumothorax in the last 2 months.\nInternal, neurologic, rheumatologic or psychiatric disease including current heavy smoking (>20 cigarettes per day)\nKnown renal failure or allergy to acetazolamide and other sulfonamides\n"
],
"offsets": [
[
0,
525
]
]
}
] | [
{
"id": "NCT03177837_exc_T1",
"type": "Condition",
"text": [
"COPD exacerbation"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T2",
"type": "Qualifier",
"text": [
"very severe"
],
"offsets": [
[
19,
30
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T3",
"type": "Condition",
"text": [
"COPD"
],
"offsets": [
[
31,
35
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T4",
"type": "Condition",
"text": [
"hypoxemia"
],
"offsets": [
[
41,
50
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T5",
"type": "Qualifier",
"text": [
"low altitude"
],
"offsets": [
[
54,
66
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T6",
"type": "Measurement",
"text": [
"FEV1/FVC"
],
"offsets": [
[
68,
76
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T7",
"type": "Value",
"text": [
"<0.7"
],
"offsets": [
[
77,
81
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T8",
"type": "Measurement",
"text": [
"FEV1"
],
"offsets": [
[
83,
87
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T9",
"type": "Value",
"text": [
"<40% predicted"
],
"offsets": [
[
88,
102
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T10",
"type": "Measurement",
"text": [
"oxygen saturation"
],
"offsets": [
[
104,
121
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T11",
"type": "Qualifier",
"text": [
"room air"
],
"offsets": [
[
125,
133
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T12",
"type": "Value",
"text": [
"<92%"
],
"offsets": [
[
134,
138
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T13",
"type": "Qualifier",
"text": [
"750 m"
],
"offsets": [
[
142,
147
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T14",
"type": "Condition",
"text": [
"cardiovascular disease"
],
"offsets": [
[
185,
207
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T15",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
172,
184
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T16",
"type": "Condition",
"text": [
"Comorbidities"
],
"offsets": [
[
150,
163
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T17",
"type": "Qualifier",
"text": [
"unstable"
],
"offsets": [
[
215,
223
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T18",
"type": "Condition",
"text": [
"systemic arterial hypertension"
],
"offsets": [
[
224,
254
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T19",
"type": "Condition",
"text": [
"coronary artery disease"
],
"offsets": [
[
256,
279
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T20",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
281,
289
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T21",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
290,
296
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T22",
"type": "Condition",
"text": [
"OSA"
],
"offsets": [
[
298,
301
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T23",
"type": "Condition",
"text": [
"pneumothorax"
],
"offsets": [
[
303,
315
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T24",
"type": "Temporal",
"text": [
"in the last 2 months"
],
"offsets": [
[
316,
336
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T25",
"type": "Scope",
"text": [
"uncontrolled cardiovascular disease, i.e., unstable systemic arterial hypertension, coronary artery disease; previous stroke; OSA; pneumothorax in the last 2 months"
],
"offsets": [
[
172,
336
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T26",
"type": "Qualifier",
"text": [
"Internal"
],
"offsets": [
[
338,
346
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T27",
"type": "Qualifier",
"text": [
"neurologic"
],
"offsets": [
[
348,
358
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T28",
"type": "Qualifier",
"text": [
"rheumatologic"
],
"offsets": [
[
360,
373
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T29",
"type": "Qualifier",
"text": [
"psychiatric"
],
"offsets": [
[
377,
388
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T30",
"type": "Condition",
"text": [
"disease"
],
"offsets": [
[
389,
396
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T31",
"type": "Temporal",
"text": [
"current"
],
"offsets": [
[
407,
414
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T32",
"type": "Observation",
"text": [
"smoking"
],
"offsets": [
[
421,
428
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T33",
"type": "Qualifier",
"text": [
"heavy"
],
"offsets": [
[
415,
420
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T34",
"type": "Value",
"text": [
">20"
],
"offsets": [
[
430,
433
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T35",
"type": "Measurement",
"text": [
"cigarettes per day"
],
"offsets": [
[
434,
452
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T36",
"type": "Scope",
"text": [
">20 cigarettes per day"
],
"offsets": [
[
430,
452
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T37",
"type": "Scope",
"text": [
"heavy smoking"
],
"offsets": [
[
415,
428
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T38",
"type": "Scope",
"text": [
"heavy smoking (>20 cigarettes per day)"
],
"offsets": [
[
415,
453
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T39",
"type": "Scope",
"text": [
"Internal, neurologic, rheumatologic or psychiatric"
],
"offsets": [
[
338,
388
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T40",
"type": "Condition",
"text": [
"renal failure"
],
"offsets": [
[
460,
473
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T41",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
477,
484
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T42",
"type": "Drug",
"text": [
"acetazolamide"
],
"offsets": [
[
488,
501
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T43",
"type": "Drug",
"text": [
"sulfonamides"
],
"offsets": [
[
512,
524
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T44",
"type": "Qualifier",
"text": [
"other"
],
"offsets": [
[
506,
511
]
],
"normalized": []
},
{
"id": "NCT03177837_exc_T45",
"type": "Scope",
"text": [
"acetazolamide and other sulfonamides"
],
"offsets": [
[
488,
524
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03177837_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03177837_exc_T4",
"arg2_id": "NCT03177837_exc_T5",
"normalized": []
},
{
"id": "NCT03177837_exc_R2",
"type": "AND",
"arg1_id": "NCT03177837_exc_T3",
"arg2_id": "NCT03177837_exc_T4",
"normalized": []
},
{
"id": "NCT03177837_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT03177837_exc_T3",
"arg2_id": "NCT03177837_exc_T2",
"normalized": []
},
{
"id": "NCT03177837_exc_R4",
"type": "Has_value",
"arg1_id": "NCT03177837_exc_T8",
"arg2_id": "NCT03177837_exc_T9",
"normalized": []
},
{
"id": "NCT03177837_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT03177837_exc_T10",
"arg2_id": "NCT03177837_exc_T11",
"normalized": []
},
{
"id": "NCT03177837_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT03177837_exc_T10",
"arg2_id": "NCT03177837_exc_T13",
"normalized": []
},
{
"id": "NCT03177837_exc_R7",
"type": "Has_value",
"arg1_id": "NCT03177837_exc_T10",
"arg2_id": "NCT03177837_exc_T12",
"normalized": []
},
{
"id": "NCT03177837_exc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT03177837_exc_T18",
"arg2_id": "NCT03177837_exc_T17",
"normalized": []
},
{
"id": "NCT03177837_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT03177837_exc_T23",
"arg2_id": "NCT03177837_exc_T24",
"normalized": []
},
{
"id": "NCT03177837_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT03177837_exc_T14",
"arg2_id": "NCT03177837_exc_T15",
"normalized": []
},
{
"id": "NCT03177837_exc_R11",
"type": "Has_temporal",
"arg1_id": "NCT03177837_exc_T21",
"arg2_id": "NCT03177837_exc_T20",
"normalized": []
},
{
"id": "NCT03177837_exc_R12",
"type": "Subsumes",
"arg1_id": "NCT03177837_exc_T16",
"arg2_id": "NCT03177837_exc_T25",
"normalized": []
},
{
"id": "NCT03177837_exc_R13",
"type": "Has_value",
"arg1_id": "NCT03177837_exc_T35",
"arg2_id": "NCT03177837_exc_T34",
"normalized": []
},
{
"id": "NCT03177837_exc_R14",
"type": "Has_qualifier",
"arg1_id": "NCT03177837_exc_T32",
"arg2_id": "NCT03177837_exc_T33",
"normalized": []
},
{
"id": "NCT03177837_exc_R15",
"type": "Subsumes",
"arg1_id": "NCT03177837_exc_T37",
"arg2_id": "NCT03177837_exc_T36",
"normalized": []
},
{
"id": "NCT03177837_exc_R16",
"type": "Has_temporal",
"arg1_id": "NCT03177837_exc_T38",
"arg2_id": "NCT03177837_exc_T31",
"normalized": []
},
{
"id": "NCT03177837_exc_R17",
"type": "Has_scope",
"arg1_id": "NCT03177837_exc_T30",
"arg2_id": "NCT03177837_exc_T39",
"normalized": []
},
{
"id": "NCT03177837_exc_R18",
"type": "Has_scope",
"arg1_id": "NCT03177837_exc_T39",
"arg2_id": "NCT03177837_exc_T37",
"normalized": []
},
{
"id": "NCT03177837_exc_R19",
"type": "Has_scope",
"arg1_id": "NCT03177837_exc_T41",
"arg2_id": "NCT03177837_exc_T45",
"normalized": []
}
] |
NCT03177837_inc | NCT03177837 | [
{
"id": "NCT03177837_inc_text",
"type": "inclusion",
"text": [
"Male and female patients, age 18-75 yrs.\nCOPD diagnosed according to GOLD, FEV1 40-80% predicted, SpO2 =92% at 750 m.\nBorn, raised and currently living at low altitude (<800m).\nWritten informed consent.\n"
],
"offsets": [
[
0,
203
]
]
}
] | [
{
"id": "NCT03177837_inc_T1",
"type": "Person",
"text": [
"Male"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT03177837_inc_T2",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
9,
15
]
],
"normalized": []
},
{
"id": "NCT03177837_inc_T3",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
26,
29
]
],
"normalized": []
},
{
"id": "NCT03177837_inc_T4",
"type": "Value",
"text": [
"18-75 yrs"
],
"offsets": [
[
30,
39
]
],
"normalized": []
},
{
"id": "NCT03177837_inc_T5",
"type": "Condition",
"text": [
"COPD"
],
"offsets": [
[
41,
45
]
],
"normalized": []
},
{
"id": "NCT03177837_inc_T6",
"type": "Qualifier",
"text": [
"GOLD"
],
"offsets": [
[
69,
73
]
],
"normalized": []
},
{
"id": "NCT03177837_inc_T7",
"type": "Measurement",
"text": [
"FEV1"
],
"offsets": [
[
75,
79
]
],
"normalized": []
},
{
"id": "NCT03177837_inc_T8",
"type": "Value",
"text": [
"40-80% predicted"
],
"offsets": [
[
80,
96
]
],
"normalized": []
},
{
"id": "NCT03177837_inc_T9",
"type": "Measurement",
"text": [
"SpO2"
],
"offsets": [
[
98,
102
]
],
"normalized": []
},
{
"id": "NCT03177837_inc_T10",
"type": "Value",
"text": [
"=92%"
],
"offsets": [
[
103,
107
]
],
"normalized": []
},
{
"id": "NCT03177837_inc_T11",
"type": "Qualifier",
"text": [
"750 m"
],
"offsets": [
[
111,
116
]
],
"normalized": []
},
{
"id": "NCT03177837_inc_T12",
"type": "Observation",
"text": [
"living at low altitude"
],
"offsets": [
[
145,
167
]
],
"normalized": []
},
{
"id": "NCT03177837_inc_T13",
"type": "Value",
"text": [
"<800m"
],
"offsets": [
[
169,
174
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03177837_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03177837_inc_T3",
"arg2_id": "NCT03177837_inc_T4",
"normalized": []
},
{
"id": "NCT03177837_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03177837_inc_T7",
"arg2_id": "NCT03177837_inc_T8",
"normalized": []
},
{
"id": "NCT03177837_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT03177837_inc_T9",
"arg2_id": "NCT03177837_inc_T11",
"normalized": []
},
{
"id": "NCT03177837_inc_R4",
"type": "Has_value",
"arg1_id": "NCT03177837_inc_T9",
"arg2_id": "NCT03177837_inc_T10",
"normalized": []
},
{
"id": "NCT03177837_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT03177837_inc_T5",
"arg2_id": "NCT03177837_inc_T6",
"normalized": []
},
{
"id": "NCT03177837_inc_R6",
"type": "Has_value",
"arg1_id": "NCT03177837_inc_T12",
"arg2_id": "NCT03177837_inc_T13",
"normalized": []
}
] |
NCT03181984_exc | NCT03181984 | [
{
"id": "NCT03181984_exc_text",
"type": "exclusion",
"text": [
"Allergy to porphyrins and analogues; Photosensitivity; Porphyria; Allergic constitution;\nScar diathesis;\nPregnancy or unwilling to adopt reliable contraceptive measures during the month after drug application;\nBe judged not suitable to participate the study by the investigators\n"
],
"offsets": [
[
0,
279
]
]
}
] | [
{
"id": "NCT03181984_exc_T1",
"type": "Condition",
"text": [
"Allergy"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "NCT03181984_exc_T2",
"type": "Drug",
"text": [
"porphyrins"
],
"offsets": [
[
11,
21
]
],
"normalized": []
},
{
"id": "NCT03181984_exc_T3",
"type": "Drug",
"text": [
"porphyrins",
"analogues"
],
"offsets": [
[
11,
21
],
[
26,
35
]
],
"normalized": []
},
{
"id": "NCT03181984_exc_T4",
"type": "Condition",
"text": [
"Photosensitivity"
],
"offsets": [
[
37,
53
]
],
"normalized": []
},
{
"id": "NCT03181984_exc_T5",
"type": "Condition",
"text": [
"Porphyria"
],
"offsets": [
[
55,
64
]
],
"normalized": []
},
{
"id": "NCT03181984_exc_T6",
"type": "Condition",
"text": [
"Allergic constitution"
],
"offsets": [
[
66,
87
]
],
"normalized": []
},
{
"id": "NCT03181984_exc_T7",
"type": "Scope",
"text": [
"porphyrins and analogues"
],
"offsets": [
[
11,
35
]
],
"normalized": []
},
{
"id": "NCT03181984_exc_T8",
"type": "Condition",
"text": [
"Scar diathesis"
],
"offsets": [
[
89,
103
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03181984_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT03181984_exc_T1",
"arg2_id": "NCT03181984_exc_T7",
"normalized": []
}
] |
NCT03181984_inc | NCT03181984 | [
{
"id": "NCT03181984_inc_text",
"type": "inclusion",
"text": [
"Age range: 14 to 65 years-old;\nClinically diagnosed of Port-wine Stain;\nPatients receiving hemoporfin based upon the clinical judgment of the investigator;\nWritten informed consent signed and agreed to receive periodic follow-up\n"
],
"offsets": [
[
0,
229
]
]
}
] | [
{
"id": "NCT03181984_inc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT03181984_inc_T2",
"type": "Value",
"text": [
"14 to 65 years-old"
],
"offsets": [
[
11,
29
]
],
"normalized": []
},
{
"id": "NCT03181984_inc_T3",
"type": "Condition",
"text": [
"Port-wine Stain"
],
"offsets": [
[
55,
70
]
],
"normalized": []
},
{
"id": "NCT03181984_inc_T4",
"type": "Drug",
"text": [
"hemoporfin"
],
"offsets": [
[
91,
101
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03181984_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03181984_inc_T1",
"arg2_id": "NCT03181984_inc_T2",
"normalized": []
}
] |
NCT03182114_exc | NCT03182114 | [
{
"id": "NCT03182114_exc_text",
"type": "exclusion",
"text": [
"Cardiac morbidities\nhypertensive disorders of pregnancy\nperipartum bleeding\nbaseline systolic blood pressure (SBP) < 100 mmHg\nbody mass index > 35\n"
],
"offsets": [
[
0,
147
]
]
}
] | [
{
"id": "NCT03182114_exc_T1",
"type": "Condition",
"text": [
"Cardiac morbidities"
],
"offsets": [
[
0,
19
]
],
"normalized": []
},
{
"id": "NCT03182114_exc_T2",
"type": "Condition",
"text": [
"hypertensive disorders of pregnancy"
],
"offsets": [
[
20,
55
]
],
"normalized": []
},
{
"id": "NCT03182114_exc_T3",
"type": "Condition",
"text": [
"peripartum bleeding"
],
"offsets": [
[
56,
75
]
],
"normalized": []
},
{
"id": "NCT03182114_exc_T4",
"type": "Temporal",
"text": [
"baseline"
],
"offsets": [
[
76,
84
]
],
"normalized": []
},
{
"id": "NCT03182114_exc_T5",
"type": "Measurement",
"text": [
"systolic blood pressure"
],
"offsets": [
[
85,
108
]
],
"normalized": []
},
{
"id": "NCT03182114_exc_T6",
"type": "Measurement",
"text": [
"SBP"
],
"offsets": [
[
110,
113
]
],
"normalized": []
},
{
"id": "NCT03182114_exc_T7",
"type": "Value",
"text": [
"< 100 mmHg"
],
"offsets": [
[
115,
125
]
],
"normalized": []
},
{
"id": "NCT03182114_exc_T8",
"type": "Measurement",
"text": [
"body mass index"
],
"offsets": [
[
126,
141
]
],
"normalized": []
},
{
"id": "NCT03182114_exc_T9",
"type": "Value",
"text": [
"> 35"
],
"offsets": [
[
142,
146
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03182114_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT03182114_exc_T5",
"arg2_id": "NCT03182114_exc_T6",
"normalized": []
},
{
"id": "NCT03182114_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03182114_exc_T5",
"arg2_id": "NCT03182114_exc_T7",
"normalized": []
},
{
"id": "NCT03182114_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT03182114_exc_T5",
"arg2_id": "NCT03182114_exc_T4",
"normalized": []
},
{
"id": "NCT03182114_exc_R4",
"type": "Has_value",
"arg1_id": "NCT03182114_exc_T8",
"arg2_id": "NCT03182114_exc_T9",
"normalized": []
}
] |
NCT03182114_inc | NCT03182114 | [
{
"id": "NCT03182114_inc_text",
"type": "inclusion",
"text": [
"full term\nsingleton pregnant women\nscheduled for elective cesarean delivery\n"
],
"offsets": [
[
0,
76
]
]
}
] | [
{
"id": "NCT03182114_inc_T1",
"type": "Condition",
"text": [
"full term"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT03182114_inc_T2",
"type": "Qualifier",
"text": [
"singleton"
],
"offsets": [
[
10,
19
]
],
"normalized": []
},
{
"id": "NCT03182114_inc_T3",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
20,
28
]
],
"normalized": []
},
{
"id": "NCT03182114_inc_T4",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
29,
34
]
],
"normalized": []
},
{
"id": "NCT03182114_inc_T5",
"type": "Qualifier",
"text": [
"elective"
],
"offsets": [
[
49,
57
]
],
"normalized": []
},
{
"id": "NCT03182114_inc_T6",
"type": "Procedure",
"text": [
"cesarean delivery"
],
"offsets": [
[
58,
75
]
],
"normalized": []
},
{
"id": "NCT03182114_inc_T7",
"type": "Mood",
"text": [
"scheduled for"
],
"offsets": [
[
35,
48
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03182114_inc_R1",
"type": "Has_mood",
"arg1_id": "NCT03182114_inc_T6",
"arg2_id": "NCT03182114_inc_T7",
"normalized": []
},
{
"id": "NCT03182114_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03182114_inc_T6",
"arg2_id": "NCT03182114_inc_T5",
"normalized": []
}
] |
NCT03185130_exc | NCT03185130 | [
{
"id": "NCT03185130_exc_text",
"type": "exclusion",
"text": [
"Pregnant\nMeningeal signs are present\nAcute angle closure glaucoma is suspected\nHead trauma within the previous two weeks\nLumbar puncture within the previous two weeks\nThunderclap onset of the headache\nKnown allergy to one of the study drugs\nHistory of intracranial hypertension\nIs a prisoner\nPatient declined informed consent\nNon-English speaking patient or parent/guardian for pediatric patients\nAttending provider excludes patient\nSevere Dehydration\n"
],
"offsets": [
[
0,
452
]
]
}
] | [
{
"id": "NCT03185130_exc_T1",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T2",
"type": "Condition",
"text": [
"Meningeal signs"
],
"offsets": [
[
9,
24
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T3",
"type": "Condition",
"text": [
"Acute angle closure glaucoma"
],
"offsets": [
[
37,
65
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T4",
"type": "Mood",
"text": [
"suspected"
],
"offsets": [
[
69,
78
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T5",
"type": "Condition",
"text": [
"Head trauma"
],
"offsets": [
[
79,
90
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T6",
"type": "Temporal",
"text": [
"within the previous two weeks"
],
"offsets": [
[
91,
120
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T7",
"type": "Procedure",
"text": [
"Lumbar puncture"
],
"offsets": [
[
121,
136
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T8",
"type": "Temporal",
"text": [
"within the previous two weeks"
],
"offsets": [
[
137,
166
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T9",
"type": "Condition",
"text": [
"Thunderclap onset"
],
"offsets": [
[
167,
184
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T10",
"type": "Condition",
"text": [
"headache"
],
"offsets": [
[
192,
200
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T11",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
207,
214
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T12",
"type": "Drug",
"text": [
"study drugs"
],
"offsets": [
[
229,
240
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T13",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
241,
248
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T14",
"type": "Condition",
"text": [
"intracranial hypertension"
],
"offsets": [
[
252,
277
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T15",
"type": "Person",
"text": [
"prisoner"
],
"offsets": [
[
283,
291
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T17",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
433,
439
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T18",
"type": "Condition",
"text": [
"Dehydration"
],
"offsets": [
[
440,
451
]
],
"normalized": []
},
{
"id": "NCT03185130_exc_T16",
"type": "Negation",
"text": [
"declined"
],
"offsets": [
[
300,
308
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03185130_exc_R1",
"type": "Has_mood",
"arg1_id": "NCT03185130_exc_T3",
"arg2_id": "NCT03185130_exc_T4",
"normalized": []
},
{
"id": "NCT03185130_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT03185130_exc_T5",
"arg2_id": "NCT03185130_exc_T6",
"normalized": []
},
{
"id": "NCT03185130_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT03185130_exc_T7",
"arg2_id": "NCT03185130_exc_T8",
"normalized": []
},
{
"id": "NCT03185130_exc_R4",
"type": "AND",
"arg1_id": "NCT03185130_exc_T10",
"arg2_id": "NCT03185130_exc_T9",
"normalized": []
},
{
"id": "NCT03185130_exc_R5",
"type": "AND",
"arg1_id": "NCT03185130_exc_T11",
"arg2_id": "NCT03185130_exc_T12",
"normalized": []
},
{
"id": "NCT03185130_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT03185130_exc_T14",
"arg2_id": "NCT03185130_exc_T13",
"normalized": []
},
{
"id": "NCT03185130_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT03185130_exc_T18",
"arg2_id": "NCT03185130_exc_T17",
"normalized": []
}
] |
NCT03185130_inc | NCT03185130 | [
{
"id": "NCT03185130_inc_text",
"type": "inclusion",
"text": [
"Age 10 to 65 years\nTemperature less than 100.4 F\nNormal neurologic exam and normal mental status\n"
],
"offsets": [
[
0,
97
]
]
}
] | [
{
"id": "NCT03185130_inc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT03185130_inc_T2",
"type": "Value",
"text": [
"10 to 65 years"
],
"offsets": [
[
4,
18
]
],
"normalized": []
},
{
"id": "NCT03185130_inc_T3",
"type": "Measurement",
"text": [
"Temperature"
],
"offsets": [
[
19,
30
]
],
"normalized": []
},
{
"id": "NCT03185130_inc_T4",
"type": "Value",
"text": [
"less than 100.4 F"
],
"offsets": [
[
31,
48
]
],
"normalized": []
},
{
"id": "NCT03185130_inc_T5",
"type": "Procedure",
"text": [
"neurologic exam"
],
"offsets": [
[
56,
71
]
],
"normalized": []
},
{
"id": "NCT03185130_inc_T6",
"type": "Value",
"text": [
"Normal"
],
"offsets": [
[
49,
55
]
],
"normalized": []
},
{
"id": "NCT03185130_inc_T7",
"type": "Value",
"text": [
"normal"
],
"offsets": [
[
76,
82
]
],
"normalized": []
},
{
"id": "NCT03185130_inc_T8",
"type": "Measurement",
"text": [
"mental status"
],
"offsets": [
[
83,
96
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03185130_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03185130_inc_T1",
"arg2_id": "NCT03185130_inc_T2",
"normalized": []
},
{
"id": "NCT03185130_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03185130_inc_T3",
"arg2_id": "NCT03185130_inc_T4",
"normalized": []
},
{
"id": "NCT03185130_inc_R3",
"type": "Has_value",
"arg1_id": "NCT03185130_inc_T5",
"arg2_id": "NCT03185130_inc_T6",
"normalized": []
}
] |
NCT03187379_exc | NCT03187379 | [
{
"id": "NCT03187379_exc_text",
"type": "exclusion",
"text": [
"age <18 years\nprevious history of roux-en-y gastric bypass\npatients undergoing other bariatric procedures\npre-operative opioid analgesics\n"
],
"offsets": [
[
0,
138
]
]
}
] | [
{
"id": "NCT03187379_exc_T1",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT03187379_exc_T2",
"type": "Value",
"text": [
"<18 years"
],
"offsets": [
[
4,
13
]
],
"normalized": []
},
{
"id": "NCT03187379_exc_T3",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
23,
30
]
],
"normalized": []
},
{
"id": "NCT03187379_exc_T4",
"type": "Procedure",
"text": [
"roux-en-y gastric bypass"
],
"offsets": [
[
34,
58
]
],
"normalized": []
},
{
"id": "NCT03187379_exc_T5",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
14,
22
]
],
"normalized": []
},
{
"id": "NCT03187379_exc_T6",
"type": "Procedure",
"text": [
"bariatric procedures"
],
"offsets": [
[
85,
105
]
],
"normalized": []
},
{
"id": "NCT03187379_exc_T7",
"type": "Qualifier",
"text": [
"other"
],
"offsets": [
[
79,
84
]
],
"normalized": []
},
{
"id": "NCT03187379_exc_T8",
"type": "Temporal",
"text": [
"undergoing"
],
"offsets": [
[
68,
78
]
],
"normalized": []
},
{
"id": "NCT03187379_exc_T9",
"type": "Temporal",
"text": [
"pre-operative"
],
"offsets": [
[
106,
119
]
],
"normalized": []
},
{
"id": "NCT03187379_exc_T10",
"type": "Drug",
"text": [
"opioid analgesics"
],
"offsets": [
[
120,
137
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03187379_exc_R1",
"type": "Has_value",
"arg1_id": "NCT03187379_exc_T1",
"arg2_id": "NCT03187379_exc_T2",
"normalized": []
},
{
"id": "NCT03187379_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT03187379_exc_T4",
"arg2_id": "NCT03187379_exc_T3",
"normalized": []
},
{
"id": "NCT03187379_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT03187379_exc_T4",
"arg2_id": "NCT03187379_exc_T5",
"normalized": []
},
{
"id": "NCT03187379_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT03187379_exc_T6",
"arg2_id": "NCT03187379_exc_T7",
"normalized": []
},
{
"id": "NCT03187379_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT03187379_exc_T6",
"arg2_id": "NCT03187379_exc_T8",
"normalized": []
},
{
"id": "NCT03187379_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT03187379_exc_T10",
"arg2_id": "NCT03187379_exc_T9",
"normalized": []
}
] |
NCT03187379_inc | NCT03187379 | [
{
"id": "NCT03187379_inc_text",
"type": "inclusion",
"text": [
"bariatric surgery patients\nlaparoscopic roux-en-y gastric bypass\nuse of EEA stapler anastomosis\n"
],
"offsets": [
[
0,
96
]
]
}
] | [
{
"id": "NCT03187379_inc_T1",
"type": "Procedure",
"text": [
"bariatric surgery"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "NCT03187379_inc_T2",
"type": "Procedure",
"text": [
"roux-en-y gastric bypass"
],
"offsets": [
[
40,
64
]
],
"normalized": []
},
{
"id": "NCT03187379_inc_T3",
"type": "Qualifier",
"text": [
"laparoscopic"
],
"offsets": [
[
27,
39
]
],
"normalized": []
},
{
"id": "NCT03187379_inc_T4",
"type": "Device",
"text": [
"EEA stapler anastomosis"
],
"offsets": [
[
72,
95
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03187379_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03187379_inc_T2",
"arg2_id": "NCT03187379_inc_T3",
"normalized": []
}
] |
NCT03187639_exc | NCT03187639 | [
{
"id": "NCT03187639_exc_text",
"type": "exclusion",
"text": [
"Atrial fibrillation of new onset or when rate control has been difficult\nKnown bigemini/trigeminy\nPrior CABG surgery\nAllergic to contrast\nAdvanced renal impairment\nSignificant valve disease (severe aortic stenosis or regurgitation; severe mitral regurgitation)\nLife expectancy <12 months\nInclusion in another trial without prior agreement with CI\n"
],
"offsets": [
[
0,
347
]
]
}
] | [
{
"id": "NCT03187639_exc_T1",
"type": "Condition",
"text": [
"Atrial fibrillation"
],
"offsets": [
[
0,
19
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T2",
"type": "Temporal",
"text": [
"new onset"
],
"offsets": [
[
23,
32
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T3",
"type": "Condition",
"text": [
"rate control has been difficult"
],
"offsets": [
[
41,
72
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T4",
"type": "Condition",
"text": [
"bigemini"
],
"offsets": [
[
79,
87
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T5",
"type": "Condition",
"text": [
"trigeminy"
],
"offsets": [
[
88,
97
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T6",
"type": "Temporal",
"text": [
"Prior"
],
"offsets": [
[
98,
103
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T7",
"type": "Procedure",
"text": [
"CABG surgery"
],
"offsets": [
[
104,
116
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T8",
"type": "Condition",
"text": [
"Allergic"
],
"offsets": [
[
117,
125
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T9",
"type": "Drug",
"text": [
"contrast"
],
"offsets": [
[
129,
137
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T10",
"type": "Condition",
"text": [
"Advanced renal impairment"
],
"offsets": [
[
138,
163
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T11",
"type": "Condition",
"text": [
"valve disease"
],
"offsets": [
[
176,
189
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T12",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
191,
197
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T13",
"type": "Condition",
"text": [
"aortic stenosis"
],
"offsets": [
[
198,
213
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T14",
"type": "Condition",
"text": [
"regurgitation"
],
"offsets": [
[
217,
230
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T15",
"type": "Scope",
"text": [
"aortic stenosis or regurgitation"
],
"offsets": [
[
198,
230
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T16",
"type": "Condition",
"text": [
"mitral regurgitation"
],
"offsets": [
[
239,
259
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T17",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
232,
238
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T18",
"type": "Observation",
"text": [
"Life expectancy"
],
"offsets": [
[
261,
276
]
],
"normalized": []
},
{
"id": "NCT03187639_exc_T19",
"type": "Value",
"text": [
"<12 months"
],
"offsets": [
[
277,
287
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03187639_exc_R1",
"type": "Has_temporal",
"arg1_id": "NCT03187639_exc_T1",
"arg2_id": "NCT03187639_exc_T2",
"normalized": []
},
{
"id": "NCT03187639_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT03187639_exc_T7",
"arg2_id": "NCT03187639_exc_T6",
"normalized": []
},
{
"id": "NCT03187639_exc_R3",
"type": "AND",
"arg1_id": "NCT03187639_exc_T8",
"arg2_id": "NCT03187639_exc_T9",
"normalized": []
},
{
"id": "NCT03187639_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT03187639_exc_T15",
"arg2_id": "NCT03187639_exc_T12",
"normalized": []
},
{
"id": "NCT03187639_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT03187639_exc_T16",
"arg2_id": "NCT03187639_exc_T17",
"normalized": []
},
{
"id": "NCT03187639_exc_R6",
"type": "Has_value",
"arg1_id": "NCT03187639_exc_T18",
"arg2_id": "NCT03187639_exc_T19",
"normalized": []
}
] |
NCT03187639_inc | NCT03187639 | [
{
"id": "NCT03187639_inc_text",
"type": "inclusion",
"text": [
"Aged over 18\nPrimary symptom of chest pain\nNo contraindication to CTA\nWilling and able to provide written informed consent\n"
],
"offsets": [
[
0,
123
]
]
}
] | [
{
"id": "NCT03187639_inc_T1",
"type": "Person",
"text": [
"Aged"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT03187639_inc_T2",
"type": "Value",
"text": [
"over 18"
],
"offsets": [
[
5,
12
]
],
"normalized": []
},
{
"id": "NCT03187639_inc_T3",
"type": "Condition",
"text": [
"chest pain"
],
"offsets": [
[
32,
42
]
],
"normalized": []
},
{
"id": "NCT03187639_inc_T4",
"type": "Qualifier",
"text": [
"Primary symptom"
],
"offsets": [
[
13,
28
]
],
"normalized": []
},
{
"id": "NCT03187639_inc_T5",
"type": "Procedure",
"text": [
"CTA"
],
"offsets": [
[
66,
69
]
],
"normalized": []
},
{
"id": "NCT03187639_inc_T6",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
46,
62
]
],
"normalized": []
},
{
"id": "NCT03187639_inc_T7",
"type": "Negation",
"text": [
"No"
],
"offsets": [
[
43,
45
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03187639_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03187639_inc_T1",
"arg2_id": "NCT03187639_inc_T2",
"normalized": []
},
{
"id": "NCT03187639_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03187639_inc_T3",
"arg2_id": "NCT03187639_inc_T4",
"normalized": []
},
{
"id": "NCT03187639_inc_R3",
"type": "AND",
"arg1_id": "NCT03187639_inc_T6",
"arg2_id": "NCT03187639_inc_T5",
"normalized": []
},
{
"id": "NCT03187639_inc_R4",
"type": "Has_negation",
"arg1_id": "NCT03187639_inc_T6",
"arg2_id": "NCT03187639_inc_T7",
"normalized": []
}
] |
NCT03190304_exc | NCT03190304 | [
{
"id": "NCT03190304_exc_text",
"type": "exclusion",
"text": [
"History of hypersensitivity or allergy to any of the study drugs, drugs of similar chemical classes, ACE inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), or neprilysin inhibitors, as well as known or suspected contraindications to the study drugs.\nPrevious history of intolerance to recommended target doses of ACEIs or ARBs.\nKnown history of angioedema.\nRequirement for treatment with both ACEIs and ARBs.\nCurrent acute decompensated heart failure (exacerbation of chronic heart failure manifested by signs and symptoms that may require intravenous therapy).\nSymptomatic hypotension.\nEstimated glomerular filtration rate (eGFR) <30%.\nSerum potassium >5.4 mmol/L.\nAcute coronary syndrome, stroke, transient ischaemic attack, cardiac, carotid, or other major cardiovascular surgery, percutaneous coronary intervention, or carotid angioplasty within the 3 months.\nCoronary or carotid artery disease likely to require surgical or percutaneous intervention within the 6 months.\nImplantation of a cardiac resynchronization therapy (CRT) device within 3 months or intent to implant a CRT.\nHistory of heart transplant or on a transplant list or with left ventricular (LV) assistance device.\nHistory of severe pulmonary disease.\nDiagnosis of peripartum- or chemotherapy-induced cardiomyopathy within the 12 months.\nDocumented untreated ventricular arrhythmia with syncopal episodes within the 3 months.\nSymptomatic bradycardia or second- or third-degree atrioventricular block without a pacemaker.\nPresence of haemodynamically significant mitral and/or aortic valve disease, except mitral regurgitation secondary to LV dilatation.\nPresence of other haemodynamically significant obstructive lesions of the LV outflow tract, including aortic and subaortic stenosis.\nAny surgical or medical condition which might significantly alter the absorption, distribution, metabolism, or excretion of study drugs, including, but not limited to, any of the following: History of active inflammatory bowel disease during the 12 months. Active duodenal or gastric ulcers during the 3 months. Evidence of hepatic disease as determined by any one of the following: aspartate aminotransferase or alanine aminotransferase values exceeding 2x upper limit of normal, history of hepatic encephalopathy, history of oesophageal varices, or history of porto-caval shunt. Current treatment with cholestyramine or colestipol resins.\nPresence of any other disease with a life expectancy of <5 years.\n"
],
"offsets": [
[
0,
2475
]
]
}
] | [
{
"id": "NCT03190304_exc_T1",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
11,
27
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T2",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
31,
38
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T3",
"type": "Drug",
"text": [
"study drugs"
],
"offsets": [
[
53,
64
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T5",
"type": "Drug",
"text": [
"ACE inhibitors (ACEIs)"
],
"offsets": [
[
101,
123
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T6",
"type": "Drug",
"text": [
"angiotensin II receptor blockers (ARBs)"
],
"offsets": [
[
125,
164
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T7",
"type": "Drug",
"text": [
"neprilysin inhibitors"
],
"offsets": [
[
169,
190
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T8",
"type": "Condition",
"text": [
"contraindications"
],
"offsets": [
[
222,
239
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T9",
"type": "Mood",
"text": [
"known"
],
"offsets": [
[
203,
208
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T10",
"type": "Mood",
"text": [
"suspected"
],
"offsets": [
[
212,
221
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T11",
"type": "Scope",
"text": [
"known or suspected"
],
"offsets": [
[
203,
221
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T12",
"type": "Drug",
"text": [
"study drugs"
],
"offsets": [
[
247,
258
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T13",
"type": "Scope",
"text": [
"study drugs, drugs of similar chemical classes, ACE inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), or neprilysin inhibitors"
],
"offsets": [
[
53,
190
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T14",
"type": "Scope",
"text": [
"hypersensitivity or allergy"
],
"offsets": [
[
11,
38
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T15",
"type": "Drug",
"text": [
"ACEIs"
],
"offsets": [
[
323,
328
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T16",
"type": "Drug",
"text": [
"ARBs"
],
"offsets": [
[
332,
336
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T17",
"type": "Condition",
"text": [
"intolerance"
],
"offsets": [
[
280,
291
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T18",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
269,
276
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T19",
"type": "Temporal",
"text": [
"Previous"
],
"offsets": [
[
260,
268
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T20",
"type": "Scope",
"text": [
"ACEIs or ARBs"
],
"offsets": [
[
323,
336
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T21",
"type": "Condition",
"text": [
"angioedema"
],
"offsets": [
[
355,
365
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T22",
"type": "Drug",
"text": [
"ACEIs"
],
"offsets": [
[
403,
408
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T23",
"type": "Drug",
"text": [
"ARBs"
],
"offsets": [
[
413,
417
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T24",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
383,
392
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T25",
"type": "Mood",
"text": [
"Requirement for"
],
"offsets": [
[
367,
382
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T26",
"type": "Scope",
"text": [
"ACEIs and ARBs"
],
"offsets": [
[
403,
417
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T27",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
344,
351
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T28",
"type": "Qualifier",
"text": [
"acute"
],
"offsets": [
[
427,
432
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T29",
"type": "Qualifier",
"text": [
"decompensated"
],
"offsets": [
[
433,
446
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T30",
"type": "Condition",
"text": [
"heart failure"
],
"offsets": [
[
447,
460
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T31",
"type": "Condition",
"text": [
"exacerbation"
],
"offsets": [
[
462,
474
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T32",
"type": "Condition",
"text": [
"chronic heart failure"
],
"offsets": [
[
478,
499
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T33",
"type": "Procedure",
"text": [
"intravenous therapy"
],
"offsets": [
[
550,
569
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T34",
"type": "Condition",
"text": [
"signs"
],
"offsets": [
[
514,
519
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T35",
"type": "Condition",
"text": [
"symptoms"
],
"offsets": [
[
524,
532
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T36",
"type": "Scope",
"text": [
"signs and symptoms"
],
"offsets": [
[
514,
532
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T37",
"type": "Scope",
"text": [
"exacerbation of chronic heart failure"
],
"offsets": [
[
462,
499
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T38",
"type": "Qualifier",
"text": [
"Symptomatic"
],
"offsets": [
[
572,
583
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T39",
"type": "Condition",
"text": [
"hypotension"
],
"offsets": [
[
584,
595
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T40",
"type": "Measurement",
"text": [
"Estimated glomerular filtration rate (eGFR)"
],
"offsets": [
[
597,
640
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T41",
"type": "Value",
"text": [
"<30%"
],
"offsets": [
[
641,
645
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T42",
"type": "Measurement",
"text": [
"Serum potassium"
],
"offsets": [
[
647,
662
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T43",
"type": "Value",
"text": [
">5.4 mmol/L"
],
"offsets": [
[
663,
674
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T44",
"type": "Condition",
"text": [
"Acute coronary syndrome"
],
"offsets": [
[
676,
699
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T45",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
701,
707
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T46",
"type": "Condition",
"text": [
"transient ischaemic attack"
],
"offsets": [
[
709,
735
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T47",
"type": "Condition",
"text": [
"cardiac"
],
"offsets": [
[
737,
744
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T48",
"type": "Condition",
"text": [
"carotid"
],
"offsets": [
[
746,
753
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T49",
"type": "Procedure",
"text": [
"major cardiovascular surgery"
],
"offsets": [
[
764,
792
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T50",
"type": "Procedure",
"text": [
"percutaneous coronary intervention"
],
"offsets": [
[
794,
828
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T51",
"type": "Procedure",
"text": [
"carotid angioplasty"
],
"offsets": [
[
833,
852
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T52",
"type": "Temporal",
"text": [
"within the 3 months"
],
"offsets": [
[
853,
872
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T53",
"type": "Scope",
"text": [
"major cardiovascular surgery, percutaneous coronary intervention, or carotid angioplasty"
],
"offsets": [
[
764,
852
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T54",
"type": "Condition",
"text": [
"carotid artery disease"
],
"offsets": [
[
886,
908
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T55",
"type": "Condition",
"text": [
"or carot",
"sease likely t"
],
"offsets": [
[
883,
891
],
[
903,
917
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T56",
"type": "Procedure",
"text": [
"or percu",
"ion within t"
],
"offsets": [
[
936,
944
],
[
961,
973
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T57",
"type": "Mood",
"text": [
"likely"
],
"offsets": [
[
909,
915
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T58",
"type": "Procedure",
"text": [
"percutaneous intervention"
],
"offsets": [
[
939,
964
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T59",
"type": "Temporal",
"text": [
"within the 6 months"
],
"offsets": [
[
965,
984
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T60",
"type": "Scope",
"text": [
"surgical or percutaneous intervention"
],
"offsets": [
[
927,
964
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T61",
"type": "Scope",
"text": [
"Coronary or carotid artery disease"
],
"offsets": [
[
874,
908
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T62",
"type": "Device",
"text": [
"cardiac resynchronization therapy (CRT) device"
],
"offsets": [
[
1004,
1050
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T63",
"type": "Procedure",
"text": [
"Implantation"
],
"offsets": [
[
986,
998
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T64",
"type": "Temporal",
"text": [
"within 3 months"
],
"offsets": [
[
1051,
1066
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T65",
"type": "Mood",
"text": [
"intent"
],
"offsets": [
[
1070,
1076
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T66",
"type": "Procedure",
"text": [
"implant"
],
"offsets": [
[
1080,
1087
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T67",
"type": "Device",
"text": [
"CRT"
],
"offsets": [
[
1090,
1093
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T68",
"type": "Procedure",
"text": [
"heart transplant"
],
"offsets": [
[
1106,
1122
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T69",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
1095,
1102
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T70",
"type": "Observation",
"text": [
"on a transplant list"
],
"offsets": [
[
1126,
1146
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T71",
"type": "Device",
"text": [
"left ventricular (LV) assistance device"
],
"offsets": [
[
1155,
1194
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T72",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
1196,
1203
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T73",
"type": "Condition",
"text": [
"severe pulmonary disease"
],
"offsets": [
[
1207,
1231
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T74",
"type": "Condition",
"text": [
"cardiomyopathy"
],
"offsets": [
[
1282,
1296
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T75",
"type": "Procedure",
"text": [
"chemotherapy"
],
"offsets": [
[
1261,
1273
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T76",
"type": "Qualifier",
"text": [
"chemotherapy-induced"
],
"offsets": [
[
1261,
1281
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T77",
"type": "Condition",
"text": [
"peripartum"
],
"offsets": [
[
1246,
1256
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T78",
"type": "Qualifier",
"text": [
"r chemother",
"omyopat"
],
"offsets": [
[
1259,
1270
],
[
1287,
1294
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T79",
"type": "Scope",
"text": [
"peripartum- or chemotherapy-induced"
],
"offsets": [
[
1246,
1281
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T80",
"type": "Temporal",
"text": [
"within the 12 months"
],
"offsets": [
[
1297,
1317
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T81",
"type": "Condition",
"text": [
"ventricular arrhythmia"
],
"offsets": [
[
1340,
1362
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T82",
"type": "Qualifier",
"text": [
"untreated"
],
"offsets": [
[
1330,
1339
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T83",
"type": "Condition",
"text": [
"syncopal episodes"
],
"offsets": [
[
1368,
1385
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T84",
"type": "Temporal",
"text": [
"within the 3 months"
],
"offsets": [
[
1386,
1405
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T85",
"type": "Condition",
"text": [
"bradycardia"
],
"offsets": [
[
1419,
1430
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T86",
"type": "Condition",
"text": [
"atrioventricular block"
],
"offsets": [
[
1458,
1480
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T87",
"type": "Qualifier",
"text": [
"third-degree"
],
"offsets": [
[
1445,
1457
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T88",
"type": "Qualifier",
"text": [
"d-degre",
"tricul"
],
"offsets": [
[
1449,
1456
],
[
1466,
1472
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T89",
"type": "Negation",
"text": [
"without"
],
"offsets": [
[
1481,
1488
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T90",
"type": "Device",
"text": [
"pacemaker"
],
"offsets": [
[
1491,
1500
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T91",
"type": "Scope",
"text": [
"second- or third-degree"
],
"offsets": [
[
1434,
1457
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T92",
"type": "Qualifier",
"text": [
"haemodynamically significant"
],
"offsets": [
[
1514,
1542
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T93",
"type": "Condition",
"text": [
"aortic valve disease"
],
"offsets": [
[
1557,
1577
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T94",
"type": "Condition",
"text": [
"rtic v",
"xcept mitral"
],
"offsets": [
[
1559,
1565
],
[
1580,
1592
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T95",
"type": "Scope",
"text": [
"mitral and/or aortic valve disease"
],
"offsets": [
[
1543,
1577
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T96",
"type": "Condition",
"text": [
"mitral regurgitation"
],
"offsets": [
[
1586,
1606
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T97",
"type": "Qualifier",
"text": [
"secondary to LV dilatation"
],
"offsets": [
[
1607,
1633
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T98",
"type": "Condition",
"text": [
"LV dilatation"
],
"offsets": [
[
1620,
1633
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T99",
"type": "Negation",
"text": [
"except"
],
"offsets": [
[
1579,
1585
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T100",
"type": "Qualifier",
"text": [
"haemodynamically significant"
],
"offsets": [
[
1653,
1681
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T101",
"type": "Condition",
"text": [
"obstructive lesions"
],
"offsets": [
[
1682,
1701
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T102",
"type": "Qualifier",
"text": [
"LV outflow tract"
],
"offsets": [
[
1709,
1725
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T103",
"type": "Condition",
"text": [
"subaortic stenosis"
],
"offsets": [
[
1748,
1766
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T104",
"type": "Condition",
"text": [
"tic st",
"gical or"
],
"offsets": [
[
1754,
1760
],
[
1775,
1783
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T105",
"type": "Scope",
"text": [
"haemodynamically significant obstructive lesions of the LV outflow tract"
],
"offsets": [
[
1653,
1725
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T106",
"type": "Scope",
"text": [
"aortic and subaortic stenosis"
],
"offsets": [
[
1737,
1766
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T107",
"type": "Condition",
"text": [
"l condit",
"ght signi"
],
"offsets": [
[
1790,
1798
],
[
1810,
1819
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T108",
"type": "Condition",
"text": [
"medical condition"
],
"offsets": [
[
1784,
1801
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T109",
"type": "Condition",
"text": [
"alter the absorption, distribution, metabolism, or excretion"
],
"offsets": [
[
1828,
1888
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T110",
"type": "Drug",
"text": [
"study drugs"
],
"offsets": [
[
1892,
1903
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T111",
"type": "Condition",
"text": [
"inflammatory bowel disease"
],
"offsets": [
[
1976,
2002
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T112",
"type": "Scope",
"text": [
"surgical or medical condition"
],
"offsets": [
[
1772,
1801
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T113",
"type": "Scope",
"text": [
"surgical or medical condition which might significantly alter the absorption, distribution, metabolism, or excretion of study drugs"
],
"offsets": [
[
1772,
1903
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T114",
"type": "Temporal",
"text": [
"during the 12 months"
],
"offsets": [
[
2003,
2023
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T115",
"type": "Qualifier",
"text": [
"active"
],
"offsets": [
[
1969,
1975
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T116",
"type": "Qualifier",
"text": [
"Active"
],
"offsets": [
[
2025,
2031
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T117",
"type": "Condition",
"text": [
"c ulcers",
"3 mont"
],
"offsets": [
[
2050,
2058
],
[
2070,
2076
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T118",
"type": "Condition",
"text": [
"gastric ulcers"
],
"offsets": [
[
2044,
2058
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T119",
"type": "Scope",
"text": [
"duodenal or gastric ulcers"
],
"offsets": [
[
2032,
2058
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T120",
"type": "Temporal",
"text": [
"during the 3 months"
],
"offsets": [
[
2059,
2078
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T121",
"type": "Condition",
"text": [
"hepatic disease"
],
"offsets": [
[
2092,
2107
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T122",
"type": "Measurement",
"text": [
"aspartate aminotransferase"
],
"offsets": [
[
2151,
2177
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T123",
"type": "Measurement",
"text": [
"alanine aminotransferase"
],
"offsets": [
[
2181,
2205
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T124",
"type": "Value",
"text": [
"exceeding 2x upper limit of normal"
],
"offsets": [
[
2213,
2247
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T125",
"type": "Scope",
"text": [
"aspartate aminotransferase or alanine aminotransferase"
],
"offsets": [
[
2151,
2205
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T126",
"type": "Condition",
"text": [
"hepatic encephalopathy"
],
"offsets": [
[
2260,
2282
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T127",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
2284,
2291
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T128",
"type": "Condition",
"text": [
"oesophageal varices"
],
"offsets": [
[
2295,
2314
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T129",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
2319,
2326
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T130",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
2319,
2326
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T131",
"type": "Condition",
"text": [
"porto-caval shunt"
],
"offsets": [
[
2330,
2347
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T132",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
2357,
2366
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T133",
"type": "Temporal",
"text": [
"Current"
],
"offsets": [
[
2349,
2356
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T134",
"type": "Drug",
"text": [
"colestipol res",
"f any"
],
"offsets": [
[
2390,
2404
],
[
2419,
2424
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T135",
"type": "Drug",
"text": [
"colestipol resins"
],
"offsets": [
[
2390,
2407
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T136",
"type": "Scope",
"text": [
"cholestyramine or colestipol resins"
],
"offsets": [
[
2372,
2407
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T137",
"type": "Mood",
"text": [
"Evidence"
],
"offsets": [
[
2080,
2088
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T138",
"type": "Scope",
"text": [
"Evidence of hepatic disease"
],
"offsets": [
[
2080,
2107
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T139",
"type": "Scope",
"text": [
"aspartate aminotransferase or alanine aminotransferase values exceeding 2x upper limit of normal, history of hepatic encephalopathy, history of oesophageal varices, or history of porto-caval shunt. Current treatment with cholestyramine or colestipol resins"
],
"offsets": [
[
2151,
2407
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T140",
"type": "Scope",
"text": [
"active inflammatory bowel disease during the 12 months. Active duodenal or gastric ulcers during the 3 months. Evidence of hepatic disease as determined by any one of the following: aspartate aminotransferase or alanine aminotransferase values exceeding 2x upper limit of normal, history of hepatic encephalopathy, history of oesophageal varices, or history of porto-caval shunt. Current treatment with cholestyramine or colestipol resins"
],
"offsets": [
[
1969,
2407
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T141",
"type": "Observation",
"text": [
"life expectancy"
],
"offsets": [
[
2446,
2461
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T142",
"type": "Value",
"text": [
"<5 years"
],
"offsets": [
[
2465,
2473
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T143",
"type": "Condition",
"text": [
"disease"
],
"offsets": [
[
2431,
2438
]
],
"normalized": []
},
{
"id": "NCT03190304_exc_T144",
"type": "Qualifier",
"text": [
"any other"
],
"offsets": [
[
2421,
2430
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03190304_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT03190304_exc_T8",
"arg2_id": "NCT03190304_exc_T11",
"normalized": []
},
{
"id": "NCT03190304_exc_R2",
"type": "AND",
"arg1_id": "NCT03190304_exc_T8",
"arg2_id": "NCT03190304_exc_T12",
"normalized": []
},
{
"id": "NCT03190304_exc_R3",
"type": "Has_scope",
"arg1_id": "NCT03190304_exc_T14",
"arg2_id": "NCT03190304_exc_T13",
"normalized": []
},
{
"id": "NCT03190304_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T17",
"arg2_id": "NCT03190304_exc_T18",
"normalized": []
},
{
"id": "NCT03190304_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T17",
"arg2_id": "NCT03190304_exc_T19",
"normalized": []
},
{
"id": "NCT03190304_exc_R6",
"type": "Has_scope",
"arg1_id": "NCT03190304_exc_T17",
"arg2_id": "NCT03190304_exc_T20",
"normalized": []
},
{
"id": "NCT03190304_exc_R7",
"type": "Has_mood",
"arg1_id": "NCT03190304_exc_T24",
"arg2_id": "NCT03190304_exc_T25",
"normalized": []
},
{
"id": "NCT03190304_exc_R8",
"type": "Has_scope",
"arg1_id": "NCT03190304_exc_T24",
"arg2_id": "NCT03190304_exc_T26",
"normalized": []
},
{
"id": "NCT03190304_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T21",
"arg2_id": "NCT03190304_exc_T27",
"normalized": []
},
{
"id": "NCT03190304_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT03190304_exc_T30",
"arg2_id": "NCT03190304_exc_T29",
"normalized": []
},
{
"id": "NCT03190304_exc_R11",
"type": "Has_qualifier",
"arg1_id": "NCT03190304_exc_T30",
"arg2_id": "NCT03190304_exc_T28",
"normalized": []
},
{
"id": "NCT03190304_exc_R12",
"type": "AND",
"arg1_id": "NCT03190304_exc_T31",
"arg2_id": "NCT03190304_exc_T32",
"normalized": []
},
{
"id": "NCT03190304_exc_R13",
"type": "Has_scope",
"arg1_id": "NCT03190304_exc_T37",
"arg2_id": "NCT03190304_exc_T36",
"normalized": []
},
{
"id": "NCT03190304_exc_R14",
"type": "AND",
"arg1_id": "NCT03190304_exc_T36",
"arg2_id": "NCT03190304_exc_T33",
"normalized": []
},
{
"id": "NCT03190304_exc_R15",
"type": "Has_qualifier",
"arg1_id": "NCT03190304_exc_T39",
"arg2_id": "NCT03190304_exc_T38",
"normalized": []
},
{
"id": "NCT03190304_exc_R16",
"type": "Has_value",
"arg1_id": "NCT03190304_exc_T42",
"arg2_id": "NCT03190304_exc_T43",
"normalized": []
},
{
"id": "NCT03190304_exc_R17",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T53",
"arg2_id": "NCT03190304_exc_T52",
"normalized": []
},
{
"id": "NCT03190304_exc_R18",
"type": "Has_mood",
"arg1_id": "NCT03190304_exc_T60",
"arg2_id": "NCT03190304_exc_T57",
"normalized": []
},
{
"id": "NCT03190304_exc_R19",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T60",
"arg2_id": "NCT03190304_exc_T59",
"normalized": []
},
{
"id": "NCT03190304_exc_R20",
"type": "Has_scope",
"arg1_id": "NCT03190304_exc_T61",
"arg2_id": "NCT03190304_exc_T60",
"normalized": []
},
{
"id": "NCT03190304_exc_R21",
"type": "AND",
"arg1_id": "NCT03190304_exc_T63",
"arg2_id": "NCT03190304_exc_T62",
"normalized": []
},
{
"id": "NCT03190304_exc_R22",
"type": "AND",
"arg1_id": "NCT03190304_exc_T66",
"arg2_id": "NCT03190304_exc_T67",
"normalized": []
},
{
"id": "NCT03190304_exc_R23",
"type": "Has_mood",
"arg1_id": "NCT03190304_exc_T66",
"arg2_id": "NCT03190304_exc_T65",
"normalized": []
},
{
"id": "NCT03190304_exc_R24",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T63",
"arg2_id": "NCT03190304_exc_T64",
"normalized": []
},
{
"id": "NCT03190304_exc_R25",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T68",
"arg2_id": "NCT03190304_exc_T69",
"normalized": []
},
{
"id": "NCT03190304_exc_R26",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T73",
"arg2_id": "NCT03190304_exc_T72",
"normalized": []
},
{
"id": "NCT03190304_exc_R27",
"type": "Has_scope",
"arg1_id": "NCT03190304_exc_T74",
"arg2_id": "NCT03190304_exc_T79",
"normalized": []
},
{
"id": "NCT03190304_exc_R28",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T74",
"arg2_id": "NCT03190304_exc_T80",
"normalized": []
},
{
"id": "NCT03190304_exc_R29",
"type": "Has_qualifier",
"arg1_id": "NCT03190304_exc_T81",
"arg2_id": "NCT03190304_exc_T82",
"normalized": []
},
{
"id": "NCT03190304_exc_R30",
"type": "AND",
"arg1_id": "NCT03190304_exc_T81",
"arg2_id": "NCT03190304_exc_T83",
"normalized": []
},
{
"id": "NCT03190304_exc_R31",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T83",
"arg2_id": "NCT03190304_exc_T84",
"normalized": []
},
{
"id": "NCT03190304_exc_R32",
"type": "Has_negation",
"arg1_id": "NCT03190304_exc_T90",
"arg2_id": "NCT03190304_exc_T89",
"normalized": []
},
{
"id": "NCT03190304_exc_R33",
"type": "Has_scope",
"arg1_id": "NCT03190304_exc_T86",
"arg2_id": "NCT03190304_exc_T91",
"normalized": []
},
{
"id": "NCT03190304_exc_R34",
"type": "AND",
"arg1_id": "NCT03190304_exc_T86",
"arg2_id": "NCT03190304_exc_T90",
"normalized": []
},
{
"id": "NCT03190304_exc_R35",
"type": "Has_qualifier",
"arg1_id": "NCT03190304_exc_T95",
"arg2_id": "NCT03190304_exc_T92",
"normalized": []
},
{
"id": "NCT03190304_exc_R39",
"type": "Has_qualifier",
"arg1_id": "NCT03190304_exc_T96",
"arg2_id": "NCT03190304_exc_T97",
"normalized": []
},
{
"id": "NCT03190304_exc_R40",
"type": "Has_negation",
"arg1_id": "NCT03190304_exc_T96",
"arg2_id": "NCT03190304_exc_T99",
"normalized": []
},
{
"id": "NCT03190304_exc_R41",
"type": "AND",
"arg1_id": "NCT03190304_exc_T95",
"arg2_id": "NCT03190304_exc_T96",
"normalized": []
},
{
"id": "NCT03190304_exc_R42",
"type": "Has_qualifier",
"arg1_id": "NCT03190304_exc_T101",
"arg2_id": "NCT03190304_exc_T102",
"normalized": []
},
{
"id": "NCT03190304_exc_R43",
"type": "Subsumes",
"arg1_id": "NCT03190304_exc_T105",
"arg2_id": "NCT03190304_exc_T106",
"normalized": []
},
{
"id": "NCT03190304_exc_R44",
"type": "AND",
"arg1_id": "NCT03190304_exc_T109",
"arg2_id": "NCT03190304_exc_T110",
"normalized": []
},
{
"id": "NCT03190304_exc_R45",
"type": "AND",
"arg1_id": "NCT03190304_exc_T112",
"arg2_id": "NCT03190304_exc_T109",
"normalized": []
},
{
"id": "NCT03190304_exc_R46",
"type": "Has_qualifier",
"arg1_id": "NCT03190304_exc_T111",
"arg2_id": "NCT03190304_exc_T115",
"normalized": []
},
{
"id": "NCT03190304_exc_R47",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T111",
"arg2_id": "NCT03190304_exc_T114",
"normalized": []
},
{
"id": "NCT03190304_exc_R48",
"type": "Has_qualifier",
"arg1_id": "NCT03190304_exc_T119",
"arg2_id": "NCT03190304_exc_T116",
"normalized": []
},
{
"id": "NCT03190304_exc_R49",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T119",
"arg2_id": "NCT03190304_exc_T120",
"normalized": []
},
{
"id": "NCT03190304_exc_R50",
"type": "Has_value",
"arg1_id": "NCT03190304_exc_T125",
"arg2_id": "NCT03190304_exc_T124",
"normalized": []
},
{
"id": "NCT03190304_exc_R51",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T126",
"arg2_id": "NCT03190304_exc_T127",
"normalized": []
},
{
"id": "NCT03190304_exc_R52",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T128",
"arg2_id": "NCT03190304_exc_T129",
"normalized": []
},
{
"id": "NCT03190304_exc_R53",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T131",
"arg2_id": "NCT03190304_exc_T130",
"normalized": []
},
{
"id": "NCT03190304_exc_R54",
"type": "Has_temporal",
"arg1_id": "NCT03190304_exc_T132",
"arg2_id": "NCT03190304_exc_T133",
"normalized": []
},
{
"id": "NCT03190304_exc_R55",
"type": "Has_scope",
"arg1_id": "NCT03190304_exc_T132",
"arg2_id": "NCT03190304_exc_T136",
"normalized": []
},
{
"id": "NCT03190304_exc_R56",
"type": "Has_mood",
"arg1_id": "NCT03190304_exc_T121",
"arg2_id": "NCT03190304_exc_T137",
"normalized": []
},
{
"id": "NCT03190304_exc_R57",
"type": "Subsumes",
"arg1_id": "NCT03190304_exc_T138",
"arg2_id": "NCT03190304_exc_T139",
"normalized": []
},
{
"id": "NCT03190304_exc_R58",
"type": "Subsumes",
"arg1_id": "NCT03190304_exc_T113",
"arg2_id": "NCT03190304_exc_T140",
"normalized": []
},
{
"id": "NCT03190304_exc_R59",
"type": "Has_value",
"arg1_id": "NCT03190304_exc_T141",
"arg2_id": "NCT03190304_exc_T142",
"normalized": []
},
{
"id": "NCT03190304_exc_R60",
"type": "Has_qualifier",
"arg1_id": "NCT03190304_exc_T143",
"arg2_id": "NCT03190304_exc_T144",
"normalized": []
}
] |
NCT03190304_inc | NCT03190304 | [
{
"id": "NCT03190304_inc_text",
"type": "inclusion",
"text": [
"Symptomatic patients with heart failure (men and women) aged >18 years,\nFunctional class II, III or IV by the New York Heart Association (NYHA)\nLeft ventricular ejection fraction <35%\nIschemic and nonischemic etiology\nType B natriuretic peptide (BNP) >150 pg/ml (or pro-BNP [N-terminal-proBNP] = 600 pg / ml) or if the patient was hospitalized for cardiac decompensation within the preceding 12 months, BNP >100 pg/ml (or N-terminal-proBNP = 400 pg / ml)\n"
],
"offsets": [
[
0,
455
]
]
}
] | [
{
"id": "NCT03190304_inc_T1",
"type": "Condition",
"text": [
"heart failure"
],
"offsets": [
[
26,
39
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T2",
"type": "Person",
"text": [
"men"
],
"offsets": [
[
41,
44
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T3",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
49,
54
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T4",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
56,
60
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T5",
"type": "Value",
"text": [
">18 years"
],
"offsets": [
[
61,
70
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T7",
"type": "Condition",
"text": [
"Symptomatic"
],
"offsets": [
[
0,
11
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T6",
"type": "Measurement",
"text": [
"New York Heart Association (NYHA)"
],
"offsets": [
[
110,
143
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T8",
"type": "Value",
"text": [
"Functional class II, III or IV"
],
"offsets": [
[
72,
102
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T9",
"type": "Measurement",
"text": [
"Left ventricular ejection fraction"
],
"offsets": [
[
144,
178
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T10",
"type": "Value",
"text": [
"<35%"
],
"offsets": [
[
179,
183
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T11",
"type": "Condition",
"text": [
"hemic an",
"ology\nTy"
],
"offsets": [
[
187,
195
],
[
212,
220
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T12",
"type": "Condition",
"text": [
"nonischemic etiology"
],
"offsets": [
[
197,
217
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T13",
"type": "Measurement",
"text": [
"Type B natriuretic peptide (BNP)"
],
"offsets": [
[
218,
250
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T14",
"type": "Value",
"text": [
">150 pg/ml"
],
"offsets": [
[
251,
261
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T15",
"type": "Measurement",
"text": [
"pro-BNP [N-terminal-proBNP]"
],
"offsets": [
[
266,
293
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T16",
"type": "Value",
"text": [
"= 600 pg / ml"
],
"offsets": [
[
294,
307
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T17",
"type": "Procedure",
"text": [
"hospitalized"
],
"offsets": [
[
331,
343
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T18",
"type": "Condition",
"text": [
"cardiac decompensation"
],
"offsets": [
[
348,
370
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T19",
"type": "Temporal",
"text": [
"within the preceding 12 months"
],
"offsets": [
[
371,
401
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T20",
"type": "Scope",
"text": [
"hospitalized for cardiac decompensation within the preceding 12 months"
],
"offsets": [
[
331,
401
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T21",
"type": "Measurement",
"text": [
"BNP"
],
"offsets": [
[
403,
406
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T22",
"type": "Value",
"text": [
">100 pg/ml"
],
"offsets": [
[
407,
417
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T23",
"type": "Measurement",
"text": [
"N-terminal-proBNP"
],
"offsets": [
[
422,
439
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T24",
"type": "Value",
"text": [
"= 400 pg / ml"
],
"offsets": [
[
440,
453
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T25",
"type": "Scope",
"text": [
"BNP >100 pg/ml (or N-terminal-proBNP = 400 pg / ml)"
],
"offsets": [
[
403,
454
]
],
"normalized": []
},
{
"id": "NCT03190304_inc_T26",
"type": "Scope",
"text": [
"Type B natriuretic peptide (BNP) >150 pg/ml (or pro-BNP [N-terminal-proBNP] = 600 pg / ml)"
],
"offsets": [
[
218,
308
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03190304_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03190304_inc_T4",
"arg2_id": "NCT03190304_inc_T5",
"normalized": []
},
{
"id": "NCT03190304_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03190304_inc_T6",
"arg2_id": "NCT03190304_inc_T8",
"normalized": []
},
{
"id": "NCT03190304_inc_R3",
"type": "Has_value",
"arg1_id": "NCT03190304_inc_T9",
"arg2_id": "NCT03190304_inc_T10",
"normalized": []
},
{
"id": "NCT03190304_inc_R4",
"type": "Has_value",
"arg1_id": "NCT03190304_inc_T15",
"arg2_id": "NCT03190304_inc_T16",
"normalized": []
},
{
"id": "NCT03190304_inc_R5",
"type": "Has_value",
"arg1_id": "NCT03190304_inc_T13",
"arg2_id": "NCT03190304_inc_T14",
"normalized": []
},
{
"id": "NCT03190304_inc_R6",
"type": "AND",
"arg1_id": "NCT03190304_inc_T17",
"arg2_id": "NCT03190304_inc_T18",
"normalized": []
},
{
"id": "NCT03190304_inc_R7",
"type": "Has_temporal",
"arg1_id": "NCT03190304_inc_T17",
"arg2_id": "NCT03190304_inc_T19",
"normalized": []
},
{
"id": "NCT03190304_inc_R8",
"type": "Has_value",
"arg1_id": "NCT03190304_inc_T21",
"arg2_id": "NCT03190304_inc_T22",
"normalized": []
},
{
"id": "NCT03190304_inc_R9",
"type": "Has_value",
"arg1_id": "NCT03190304_inc_T23",
"arg2_id": "NCT03190304_inc_T24",
"normalized": []
},
{
"id": "NCT03190304_inc_R10",
"type": "Has_scope",
"arg1_id": "NCT03190304_inc_T20",
"arg2_id": "NCT03190304_inc_T25",
"normalized": []
}
] |
NCT03192020_exc | NCT03192020 | [
{
"id": "NCT03192020_exc_text",
"type": "exclusion",
"text": [
"recurrent contracture in the finger to be treated\nneurologic condition causing the loss of function of the finger to be treated\ncontraindication for collagenase clostridium histolyticym (Xiapex/Xiaflex ®)\npregnant or breast feeding\nTPED > 135° (Tubiana stage 4) in finger to be treated\nrheumatoid arthritis\nprevious fracture in finger to be treated, which affects range of motion of MP or PIP joint\nage > 80 years\n"
],
"offsets": [
[
0,
414
]
]
}
] | [
{
"id": "NCT03192020_exc_T1",
"type": "Condition",
"text": [
"contracture"
],
"offsets": [
[
10,
21
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T2",
"type": "Qualifier",
"text": [
"finger to be treated"
],
"offsets": [
[
29,
49
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T3",
"type": "Qualifier",
"text": [
"recurrent"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T4",
"type": "Condition",
"text": [
"neurologic condition"
],
"offsets": [
[
50,
70
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T5",
"type": "Condition",
"text": [
"loss of function"
],
"offsets": [
[
83,
99
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T6",
"type": "Qualifier",
"text": [
"finger to be treated"
],
"offsets": [
[
107,
127
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T7",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
128,
144
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T8",
"type": "Drug",
"text": [
"collagenase clostridium histolyticym"
],
"offsets": [
[
149,
185
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T9",
"type": "Drug",
"text": [
"Xiapex"
],
"offsets": [
[
187,
193
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T10",
"type": "Drug",
"text": [
"Xiaflex"
],
"offsets": [
[
194,
201
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T11",
"type": "Scope",
"text": [
"Xiapex/Xiaflex"
],
"offsets": [
[
187,
201
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T12",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
205,
213
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T13",
"type": "Observation",
"text": [
"breast feeding"
],
"offsets": [
[
217,
231
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T14",
"type": "Measurement",
"text": [
"TPED"
],
"offsets": [
[
232,
236
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T15",
"type": "Value",
"text": [
"> 135°"
],
"offsets": [
[
237,
243
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T16",
"type": "Measurement",
"text": [
"Tubiana"
],
"offsets": [
[
245,
252
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T17",
"type": "Value",
"text": [
"stage 4"
],
"offsets": [
[
253,
260
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T18",
"type": "Scope",
"text": [
"TPED > 135°"
],
"offsets": [
[
232,
243
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T19",
"type": "Scope",
"text": [
"Tubiana stage 4"
],
"offsets": [
[
245,
260
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T20",
"type": "Qualifier",
"text": [
"finger to be treated"
],
"offsets": [
[
265,
285
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T21",
"type": "Condition",
"text": [
"rheumatoid arthritis"
],
"offsets": [
[
286,
306
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T22",
"type": "Qualifier",
"text": [
"finger to be treated"
],
"offsets": [
[
328,
348
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T23",
"type": "Condition",
"text": [
"fracture"
],
"offsets": [
[
316,
324
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T24",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
307,
315
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T25",
"type": "Condition",
"text": [
"affects range of motion"
],
"offsets": [
[
356,
379
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T26",
"type": "Qualifier",
"text": [
"PI",
"age >"
],
"offsets": [
[
389,
391
],
[
399,
404
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T27",
"type": "Qualifier",
"text": [
"PIP joint"
],
"offsets": [
[
389,
398
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T28",
"type": "Scope",
"text": [
"MP or PIP joint"
],
"offsets": [
[
383,
398
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T29",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
399,
402
]
],
"normalized": []
},
{
"id": "NCT03192020_exc_T30",
"type": "Value",
"text": [
"> 80 years"
],
"offsets": [
[
403,
413
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03192020_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03192020_exc_T1",
"arg2_id": "NCT03192020_exc_T2",
"normalized": []
},
{
"id": "NCT03192020_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03192020_exc_T1",
"arg2_id": "NCT03192020_exc_T3",
"normalized": []
},
{
"id": "NCT03192020_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT03192020_exc_T5",
"arg2_id": "NCT03192020_exc_T6",
"normalized": []
},
{
"id": "NCT03192020_exc_R4",
"type": "AND",
"arg1_id": "NCT03192020_exc_T4",
"arg2_id": "NCT03192020_exc_T5",
"normalized": []
},
{
"id": "NCT03192020_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT03192020_exc_T8",
"arg2_id": "NCT03192020_exc_T11",
"normalized": []
},
{
"id": "NCT03192020_exc_R6",
"type": "AND",
"arg1_id": "NCT03192020_exc_T7",
"arg2_id": "NCT03192020_exc_T8",
"normalized": []
},
{
"id": "NCT03192020_exc_R7",
"type": "Has_value",
"arg1_id": "NCT03192020_exc_T14",
"arg2_id": "NCT03192020_exc_T15",
"normalized": []
},
{
"id": "NCT03192020_exc_R8",
"type": "Has_value",
"arg1_id": "NCT03192020_exc_T16",
"arg2_id": "NCT03192020_exc_T17",
"normalized": []
},
{
"id": "NCT03192020_exc_R9",
"type": "Subsumes",
"arg1_id": "NCT03192020_exc_T18",
"arg2_id": "NCT03192020_exc_T19",
"normalized": []
},
{
"id": "NCT03192020_exc_R10",
"type": "Has_qualifier",
"arg1_id": "NCT03192020_exc_T18",
"arg2_id": "NCT03192020_exc_T20",
"normalized": []
},
{
"id": "NCT03192020_exc_R11",
"type": "Has_temporal",
"arg1_id": "NCT03192020_exc_T23",
"arg2_id": "NCT03192020_exc_T24",
"normalized": []
},
{
"id": "NCT03192020_exc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT03192020_exc_T23",
"arg2_id": "NCT03192020_exc_T22",
"normalized": []
},
{
"id": "NCT03192020_exc_R13",
"type": "Has_scope",
"arg1_id": "NCT03192020_exc_T25",
"arg2_id": "NCT03192020_exc_T28",
"normalized": []
},
{
"id": "NCT03192020_exc_R14",
"type": "AND",
"arg1_id": "NCT03192020_exc_T23",
"arg2_id": "NCT03192020_exc_T25",
"normalized": []
},
{
"id": "NCT03192020_exc_R15",
"type": "Has_value",
"arg1_id": "NCT03192020_exc_T29",
"arg2_id": "NCT03192020_exc_T30",
"normalized": []
}
] |
NCT03192020_inc | NCT03192020 | [
{
"id": "NCT03192020_inc_text",
"type": "inclusion",
"text": [
"patients with =20° passive extension deficit (PED) in metacarpophalangeal (MP) or proximal interphalangeal (PIP) joint, or TPED of =30° in MP and PIP joints of finger/fingers II-V\nage > 18 years\npalpable cord\nprovision of informed consent\nability to fill the Finnish versions of questionnaires.\n"
],
"offsets": [
[
0,
295
]
]
}
] | [
{
"id": "NCT03192020_inc_T1",
"type": "Condition",
"text": [
"passive extension deficit (PED)"
],
"offsets": [
[
19,
50
]
],
"normalized": []
},
{
"id": "NCT03192020_inc_T2",
"type": "Qualifier",
"text": [
"=20°"
],
"offsets": [
[
14,
18
]
],
"normalized": []
},
{
"id": "NCT03192020_inc_T3",
"type": "Qualifier",
"text": [
"joint",
"metacarpophalangeal (MP)"
],
"offsets": [
[
113,
118
],
[
54,
78
]
],
"normalized": []
},
{
"id": "NCT03192020_inc_T4",
"type": "Qualifier",
"text": [
"proximal interphalangeal (PIP) joint"
],
"offsets": [
[
82,
118
]
],
"normalized": []
},
{
"id": "NCT03192020_inc_T5",
"type": "Scope",
"text": [
"metacarpophalangeal (MP) or proximal interphalangeal (PIP) joint"
],
"offsets": [
[
54,
118
]
],
"normalized": []
},
{
"id": "NCT03192020_inc_T6",
"type": "Condition",
"text": [
"TPED"
],
"offsets": [
[
123,
127
]
],
"normalized": []
},
{
"id": "NCT03192020_inc_T7",
"type": "Qualifier",
"text": [
"=30°"
],
"offsets": [
[
131,
135
]
],
"normalized": []
},
{
"id": "NCT03192020_inc_T8",
"type": "Qualifier",
"text": [
"MP"
],
"offsets": [
[
139,
141
]
],
"normalized": []
},
{
"id": "NCT03192020_inc_T9",
"type": "Qualifier",
"text": [
"PIP joints"
],
"offsets": [
[
146,
156
]
],
"normalized": []
},
{
"id": "NCT03192020_inc_T10",
"type": "Qualifier",
"text": [
"finger/fingers II-V"
],
"offsets": [
[
160,
179
]
],
"normalized": []
},
{
"id": "NCT03192020_inc_T11",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
180,
183
]
],
"normalized": []
},
{
"id": "NCT03192020_inc_T12",
"type": "Value",
"text": [
"> 18 years"
],
"offsets": [
[
184,
194
]
],
"normalized": []
},
{
"id": "NCT03192020_inc_T13",
"type": "Condition",
"text": [
"palpable cord"
],
"offsets": [
[
195,
208
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03192020_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03192020_inc_T1",
"arg2_id": "NCT03192020_inc_T2",
"normalized": []
},
{
"id": "NCT03192020_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT03192020_inc_T1",
"arg2_id": "NCT03192020_inc_T5",
"normalized": []
},
{
"id": "NCT03192020_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT03192020_inc_T6",
"arg2_id": "NCT03192020_inc_T7",
"normalized": []
},
{
"id": "NCT03192020_inc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT03192020_inc_T6",
"arg2_id": "NCT03192020_inc_T8",
"normalized": []
},
{
"id": "NCT03192020_inc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT03192020_inc_T6",
"arg2_id": "NCT03192020_inc_T9",
"normalized": []
},
{
"id": "NCT03192020_inc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT03192020_inc_T6",
"arg2_id": "NCT03192020_inc_T10",
"normalized": []
},
{
"id": "NCT03192020_inc_R7",
"type": "Has_value",
"arg1_id": "NCT03192020_inc_T11",
"arg2_id": "NCT03192020_inc_T12",
"normalized": []
}
] |
NCT03193684_exc | NCT03193684 | [
{
"id": "NCT03193684_exc_text",
"type": "exclusion",
"text": [
"eGFR <60 T2DM patients on insulin, GLP-1 RA or SGLT2 treatment Major organ disease type 1 diabetes\n"
],
"offsets": [
[
0,
99
]
]
}
] | [
{
"id": "NCT03193684_exc_T1",
"type": "Measurement",
"text": [
"eGFR"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT03193684_exc_T2",
"type": "Value",
"text": [
"<60"
],
"offsets": [
[
5,
8
]
],
"normalized": []
},
{
"id": "NCT03193684_exc_T3",
"type": "Condition",
"text": [
"T2DM"
],
"offsets": [
[
9,
13
]
],
"normalized": []
},
{
"id": "NCT03193684_exc_T4",
"type": "Drug",
"text": [
"insulin"
],
"offsets": [
[
26,
33
]
],
"normalized": []
},
{
"id": "NCT03193684_exc_T5",
"type": "Drug",
"text": [
"GLP-1"
],
"offsets": [
[
35,
40
]
],
"normalized": []
},
{
"id": "NCT03193684_exc_T6",
"type": "Drug",
"text": [
"RA"
],
"offsets": [
[
41,
43
]
],
"normalized": []
},
{
"id": "NCT03193684_exc_T7",
"type": "Drug",
"text": [
"SGLT2"
],
"offsets": [
[
47,
52
]
],
"normalized": []
},
{
"id": "NCT03193684_exc_T8",
"type": "Condition",
"text": [
"Major organ disease"
],
"offsets": [
[
63,
82
]
],
"normalized": []
},
{
"id": "NCT03193684_exc_T9",
"type": "Condition",
"text": [
"type 1 diabetes"
],
"offsets": [
[
83,
98
]
],
"normalized": []
},
{
"id": "NCT03193684_exc_T10",
"type": "Scope",
"text": [
"insulin, GLP-1 RA or SGLT2"
],
"offsets": [
[
26,
52
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03193684_exc_R1",
"type": "Has_value",
"arg1_id": "NCT03193684_exc_T1",
"arg2_id": "NCT03193684_exc_T2",
"normalized": []
}
] |
NCT03193684_inc | NCT03193684 | [
{
"id": "NCT03193684_inc_text",
"type": "inclusion",
"text": [
"eGFR>60 ml/min healthy volunteers type 2 diabetes patients who otherwise healthy\n"
],
"offsets": [
[
0,
81
]
]
}
] | [
{
"id": "NCT03193684_inc_T1",
"type": "Measurement",
"text": [
"eGFR"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT03193684_inc_T2",
"type": "Value",
"text": [
">60 ml/min"
],
"offsets": [
[
4,
14
]
],
"normalized": []
},
{
"id": "NCT03193684_inc_T3",
"type": "Condition",
"text": [
"healthy"
],
"offsets": [
[
15,
22
]
],
"normalized": []
},
{
"id": "NCT03193684_inc_T4",
"type": "Condition",
"text": [
"type 2 diabetes"
],
"offsets": [
[
34,
49
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03193684_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03193684_inc_T1",
"arg2_id": "NCT03193684_inc_T2",
"normalized": []
}
] |
NCT03194074_exc | NCT03194074 | [
{
"id": "NCT03194074_exc_text",
"type": "exclusion",
"text": [
"Patients with cardiac, pulmonary, hepatic, or renal dysfunction, epilepsy, or uncontrolled hypertension, or those taking medications that influence the central nervous system, are excluded from the study. Patients who show obvious alteration of mental status, or refuse to participate, are also excluded from the study.\n"
],
"offsets": [
[
0,
320
]
]
}
] | [
{
"id": "NCT03194074_exc_T1",
"type": "Condition",
"text": [
"renal dysfunction"
],
"offsets": [
[
46,
63
]
],
"normalized": []
},
{
"id": "NCT03194074_exc_T2",
"type": "Condition",
"text": [
"hepatic",
"dysfunction"
],
"offsets": [
[
34,
41
],
[
52,
63
]
],
"normalized": []
},
{
"id": "NCT03194074_exc_T3",
"type": "Condition",
"text": [
"pulmonary",
"dysfunction"
],
"offsets": [
[
23,
32
],
[
52,
63
]
],
"normalized": []
},
{
"id": "NCT03194074_exc_T4",
"type": "Condition",
"text": [
"cardiac",
"dysfunction"
],
"offsets": [
[
14,
21
],
[
52,
63
]
],
"normalized": []
},
{
"id": "NCT03194074_exc_T5",
"type": "Condition",
"text": [
"epilepsy"
],
"offsets": [
[
65,
73
]
],
"normalized": []
},
{
"id": "NCT03194074_exc_T6",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
78,
90
]
],
"normalized": []
},
{
"id": "NCT03194074_exc_T7",
"type": "Condition",
"text": [
"hypertension"
],
"offsets": [
[
91,
103
]
],
"normalized": []
},
{
"id": "NCT03194074_exc_T8",
"type": "Drug",
"text": [
"medications that influence the central nervous system"
],
"offsets": [
[
121,
174
]
],
"normalized": []
},
{
"id": "NCT03194074_exc_T9",
"type": "Condition",
"text": [
"alteration of mental status"
],
"offsets": [
[
231,
258
]
],
"normalized": []
},
{
"id": "NCT03194074_exc_T10",
"type": "Observation",
"text": [
"refuse to participate"
],
"offsets": [
[
263,
284
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03194074_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03194074_exc_T7",
"arg2_id": "NCT03194074_exc_T6",
"normalized": []
}
] |
NCT03194074_inc | NCT03194074 | [
{
"id": "NCT03194074_inc_text",
"type": "inclusion",
"text": [
"Patients scheduled for laser laryngeal surgery under general anesthesia with either Propofol or desflurane based technique.\n"
],
"offsets": [
[
0,
124
]
]
}
] | [
{
"id": "NCT03194074_inc_T1",
"type": "Mood",
"text": [
"scheduled"
],
"offsets": [
[
9,
18
]
],
"normalized": []
},
{
"id": "NCT03194074_inc_T2",
"type": "Procedure",
"text": [
"laser laryngeal surgery"
],
"offsets": [
[
23,
46
]
],
"normalized": []
},
{
"id": "NCT03194074_inc_T3",
"type": "Procedure",
"text": [
"general anesthesia"
],
"offsets": [
[
53,
71
]
],
"normalized": []
},
{
"id": "NCT03194074_inc_T4",
"type": "Drug",
"text": [
"Propofol"
],
"offsets": [
[
84,
92
]
],
"normalized": []
},
{
"id": "NCT03194074_inc_T5",
"type": "Drug",
"text": [
"desflurane"
],
"offsets": [
[
96,
106
]
],
"normalized": []
},
{
"id": "NCT03194074_inc_T6",
"type": "Scope",
"text": [
"Propofol or desflurane"
],
"offsets": [
[
84,
106
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03194074_inc_R1",
"type": "AND",
"arg1_id": "NCT03194074_inc_T2",
"arg2_id": "NCT03194074_inc_T3",
"normalized": []
},
{
"id": "NCT03194074_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT03194074_inc_T3",
"arg2_id": "NCT03194074_inc_T6",
"normalized": []
},
{
"id": "NCT03194074_inc_R3",
"type": "Has_mood",
"arg1_id": "NCT03194074_inc_T2",
"arg2_id": "NCT03194074_inc_T1",
"normalized": []
}
] |
NCT03195153_exc | NCT03195153 | [
{
"id": "NCT03195153_exc_text",
"type": "exclusion",
"text": [
"not diabetic patient;\npatients in dual antiplatelet therapy;\npatient with severe renal failure;\npatient poor responders\n"
],
"offsets": [
[
0,
120
]
]
}
] | [
{
"id": "NCT03195153_exc_T1",
"type": "Condition",
"text": [
"diabetic"
],
"offsets": [
[
4,
12
]
],
"normalized": []
},
{
"id": "NCT03195153_exc_T2",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT03195153_exc_T3",
"type": "Procedure",
"text": [
"dual antiplatelet therapy"
],
"offsets": [
[
34,
59
]
],
"normalized": []
},
{
"id": "NCT03195153_exc_T4",
"type": "Condition",
"text": [
"renal failure"
],
"offsets": [
[
81,
94
]
],
"normalized": []
},
{
"id": "NCT03195153_exc_T5",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
74,
80
]
],
"normalized": []
},
{
"id": "NCT03195153_exc_T6",
"type": "Condition",
"text": [
"poor responders"
],
"offsets": [
[
104,
119
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03195153_exc_R1",
"type": "Has_negation",
"arg1_id": "NCT03195153_exc_T1",
"arg2_id": "NCT03195153_exc_T2",
"normalized": []
},
{
"id": "NCT03195153_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03195153_exc_T4",
"arg2_id": "NCT03195153_exc_T5",
"normalized": []
}
] |
NCT03195153_inc | NCT03195153 | [
{
"id": "NCT03195153_inc_text",
"type": "inclusion",
"text": [
"diabetic patient;\ntherapy with aspirin and insulin;\npatient well responders\n"
],
"offsets": [
[
0,
76
]
]
}
] | [
{
"id": "NCT03195153_inc_T1",
"type": "Condition",
"text": [
"diabetic"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT03195153_inc_T2",
"type": "Drug",
"text": [
"aspirin"
],
"offsets": [
[
31,
38
]
],
"normalized": []
},
{
"id": "NCT03195153_inc_T3",
"type": "Drug",
"text": [
"insulin"
],
"offsets": [
[
43,
50
]
],
"normalized": []
},
{
"id": "NCT03195153_inc_T4",
"type": "Condition",
"text": [
"well responders"
],
"offsets": [
[
60,
75
]
],
"normalized": []
}
] | [] | [] | [] |
NCT03196843_exc | NCT03196843 | [
{
"id": "NCT03196843_exc_text",
"type": "exclusion",
"text": [
"Patients with a history of any other malignancy.\nConcomitant treatment with any other anticancer therapy.\nPatient have contraindication to chemotherapy(eg.uncontrolled coronarism and heart failure; History of myocardial infarction within the past 6 months, Chronic obstructive pulmonary, uncontrolled epileptic attack and other disease that investigator consider it unsuitable for the chemotherapy)\n"
],
"offsets": [
[
0,
399
]
]
}
] | [
{
"id": "NCT03196843_exc_T1",
"type": "Condition",
"text": [
"malignancy"
],
"offsets": [
[
37,
47
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T2",
"type": "Qualifier",
"text": [
"any other"
],
"offsets": [
[
27,
36
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T3",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
16,
23
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T4",
"type": "Temporal",
"text": [
"Concomitant"
],
"offsets": [
[
49,
60
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T5",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
61,
70
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T6",
"type": "Qualifier",
"text": [
"any other"
],
"offsets": [
[
76,
85
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T7",
"type": "Procedure",
"text": [
"anticancer therapy"
],
"offsets": [
[
86,
104
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T8",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
119,
135
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T9",
"type": "Procedure",
"text": [
"chemotherapy"
],
"offsets": [
[
139,
151
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T10",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
155,
167
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T11",
"type": "Condition",
"text": [
"coronarism"
],
"offsets": [
[
168,
178
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T12",
"type": "Condition",
"text": [
"heart failure"
],
"offsets": [
[
183,
196
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T13",
"type": "Scope",
"text": [
"coronarism and heart failure"
],
"offsets": [
[
168,
196
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T14",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
198,
205
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T15",
"type": "Condition",
"text": [
"myocardial infarction"
],
"offsets": [
[
209,
230
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T16",
"type": "Temporal",
"text": [
"within the past 6 months"
],
"offsets": [
[
231,
255
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T17",
"type": "Condition",
"text": [
"Chronic obstructive pulmonary"
],
"offsets": [
[
257,
286
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T18",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
288,
300
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T19",
"type": "Condition",
"text": [
"epileptic attack"
],
"offsets": [
[
301,
317
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T20",
"type": "Qualifier",
"text": [
"other"
],
"offsets": [
[
322,
327
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T21",
"type": "Condition",
"text": [
"disease"
],
"offsets": [
[
328,
335
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T22",
"type": "Condition",
"text": [
"unsuitable for the chemotherapy"
],
"offsets": [
[
366,
397
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T23",
"type": "Procedure",
"text": [
"chemotherapy"
],
"offsets": [
[
385,
397
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T24",
"type": "Scope",
"text": [
"uncontrolled coronarism and heart failure; History of myocardial infarction within the past 6 months, Chronic obstructive pulmonary, uncontrolled epileptic attack and other disease that investigator consider it unsuitable for the chemotherapy"
],
"offsets": [
[
155,
397
]
],
"normalized": []
},
{
"id": "NCT03196843_exc_T25",
"type": "Scope",
"text": [
"contraindication to chemotherapy"
],
"offsets": [
[
119,
151
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03196843_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03196843_exc_T1",
"arg2_id": "NCT03196843_exc_T2",
"normalized": []
},
{
"id": "NCT03196843_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT03196843_exc_T1",
"arg2_id": "NCT03196843_exc_T3",
"normalized": []
},
{
"id": "NCT03196843_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT03196843_exc_T7",
"arg2_id": "NCT03196843_exc_T6",
"normalized": []
},
{
"id": "NCT03196843_exc_R4",
"type": "AND",
"arg1_id": "NCT03196843_exc_T5",
"arg2_id": "NCT03196843_exc_T7",
"normalized": []
},
{
"id": "NCT03196843_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT03196843_exc_T5",
"arg2_id": "NCT03196843_exc_T4",
"normalized": []
},
{
"id": "NCT03196843_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT03196843_exc_T13",
"arg2_id": "NCT03196843_exc_T10",
"normalized": []
},
{
"id": "NCT03196843_exc_R7",
"type": "AND",
"arg1_id": "NCT03196843_exc_T8",
"arg2_id": "NCT03196843_exc_T9",
"normalized": []
},
{
"id": "NCT03196843_exc_R8",
"type": "Has_temporal",
"arg1_id": "NCT03196843_exc_T15",
"arg2_id": "NCT03196843_exc_T16",
"normalized": []
},
{
"id": "NCT03196843_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT03196843_exc_T15",
"arg2_id": "NCT03196843_exc_T14",
"normalized": []
},
{
"id": "NCT03196843_exc_R10",
"type": "AND",
"arg1_id": "NCT03196843_exc_T22",
"arg2_id": "NCT03196843_exc_T23",
"normalized": []
},
{
"id": "NCT03196843_exc_R11",
"type": "Has_qualifier",
"arg1_id": "NCT03196843_exc_T21",
"arg2_id": "NCT03196843_exc_T20",
"normalized": []
},
{
"id": "NCT03196843_exc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT03196843_exc_T19",
"arg2_id": "NCT03196843_exc_T18",
"normalized": []
},
{
"id": "NCT03196843_exc_R13",
"type": "AND",
"arg1_id": "NCT03196843_exc_T21",
"arg2_id": "NCT03196843_exc_T22",
"normalized": []
},
{
"id": "NCT03196843_exc_R14",
"type": "Subsumes",
"arg1_id": "NCT03196843_exc_T25",
"arg2_id": "NCT03196843_exc_T24",
"normalized": []
}
] |
NCT03196843_inc | NCT03196843 | [
{
"id": "NCT03196843_inc_text",
"type": "inclusion",
"text": [
"Before participate in the study, patients must understand the treatment plan and willing to participate in the study. Patients must have signed an approved informed consent.\nHistopathologic confirmed squamous cell carcinoma of head and neck ,including oral cavity, oropharynx, larynx, or hypopharynx.\nAges=65 years,Not limited to gender.\nECOG performance status =2.\nPatients with surgical contraindication or reject to surgery.\nPostoperative TNM(primary tumor,regional nodes,metastasis) staging III~IV, positive surgical margin.\nwithout evidence of distant metastases.\nNo contraindication to chemoradiotherapy.\nLife expectancy > 3 months.\nAvailable Organ function: white blood cell=3.5×109/L, Neutrophils =1.5×109/L, Hemoglobin =80g/L, Blood platelet>100×109/L; Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST)= 2.5 upper limit of normal(ULN); Total bilirubin (TBIL) <1.5 ULN;serum creatinine=1.5 ULN; creatinine clearance of = 50ml/min\n"
],
"offsets": [
[
0,
956
]
]
}
] | [
{
"id": "NCT03196843_inc_T2",
"type": "Procedure",
"text": [
"Histopathologic"
],
"offsets": [
[
174,
189
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T3",
"type": "Condition",
"text": [
"squamous cell carcinoma"
],
"offsets": [
[
200,
223
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T4",
"type": "Qualifier",
"text": [
"Histopathologic confirmed"
],
"offsets": [
[
174,
199
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T5",
"type": "Qualifier",
"text": [
"head and neck"
],
"offsets": [
[
227,
240
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T6",
"type": "Qualifier",
"text": [
"oral cavity"
],
"offsets": [
[
252,
263
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T7",
"type": "Qualifier",
"text": [
"oropharynx"
],
"offsets": [
[
265,
275
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T8",
"type": "Qualifier",
"text": [
"larynx"
],
"offsets": [
[
277,
283
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T9",
"type": "Qualifier",
"text": [
"hypopharynx"
],
"offsets": [
[
288,
299
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T10",
"type": "Scope",
"text": [
"oral cavity, oropharynx, larynx, or hypopharynx"
],
"offsets": [
[
252,
299
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T11",
"type": "Person",
"text": [
"Ages"
],
"offsets": [
[
301,
305
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T12",
"type": "Value",
"text": [
"=65 years"
],
"offsets": [
[
305,
314
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T13",
"type": "Measurement",
"text": [
"ECOG performance status"
],
"offsets": [
[
338,
361
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T14",
"type": "Value",
"text": [
"=2"
],
"offsets": [
[
362,
364
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T15",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
389,
405
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T16",
"type": "Procedure",
"text": [
"surgical"
],
"offsets": [
[
380,
388
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T17",
"type": "Observation",
"text": [
"reject"
],
"offsets": [
[
409,
415
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T18",
"type": "Procedure",
"text": [
"surgery"
],
"offsets": [
[
419,
426
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T19",
"type": "Measurement",
"text": [
"rim",
"ng III~"
],
"offsets": [
[
447,
450
],
[
492,
499
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T20",
"type": "Qualifier",
"text": [
"Postoperative"
],
"offsets": [
[
428,
441
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T21",
"type": "Value",
"text": [
"III~IV,"
],
"offsets": [
[
495,
502
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T22",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
503,
511
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T23",
"type": "Measurement",
"text": [
"surgical margin"
],
"offsets": [
[
512,
527
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T24",
"type": "Condition",
"text": [
"distant metastases"
],
"offsets": [
[
549,
567
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T25",
"type": "Negation",
"text": [
"without"
],
"offsets": [
[
529,
536
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T26",
"type": "Mood",
"text": [
"evidence"
],
"offsets": [
[
537,
545
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T27",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
572,
588
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T28",
"type": "Procedure",
"text": [
"chemoradiotherapy"
],
"offsets": [
[
592,
609
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T29",
"type": "Negation",
"text": [
"No"
],
"offsets": [
[
569,
571
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T30",
"type": "Observation",
"text": [
"Life expectancy"
],
"offsets": [
[
611,
626
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T31",
"type": "Value",
"text": [
"> 3 months"
],
"offsets": [
[
627,
637
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T32",
"type": "Measurement",
"text": [
"white blood cell"
],
"offsets": [
[
665,
681
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T33",
"type": "Value",
"text": [
"=3.5×109/L"
],
"offsets": [
[
681,
691
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T34",
"type": "Measurement",
"text": [
"Neutrophils"
],
"offsets": [
[
693,
704
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T35",
"type": "Value",
"text": [
"=1.5×109/L"
],
"offsets": [
[
705,
715
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T36",
"type": "Measurement",
"text": [
"Hemoglobin"
],
"offsets": [
[
717,
727
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T37",
"type": "Value",
"text": [
"=80g/L"
],
"offsets": [
[
728,
734
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T38",
"type": "Measurement",
"text": [
"Blood platelet"
],
"offsets": [
[
736,
750
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T39",
"type": "Value",
"text": [
">100×109/L"
],
"offsets": [
[
750,
760
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T40",
"type": "Measurement",
"text": [
"Alanine aminotransferase (ALT)"
],
"offsets": [
[
762,
792
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T41",
"type": "Measurement",
"text": [
"Aspartate aminotransferase (AST)"
],
"offsets": [
[
797,
829
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T42",
"type": "Value",
"text": [
"= 2.5 upper limit of normal(ULN)"
],
"offsets": [
[
829,
861
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T43",
"type": "Measurement",
"text": [
"Total bilirubin (TBIL)"
],
"offsets": [
[
863,
885
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T44",
"type": "Value",
"text": [
"<1.5 ULN"
],
"offsets": [
[
886,
894
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T45",
"type": "Measurement",
"text": [
"serum creatinine"
],
"offsets": [
[
895,
911
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T46",
"type": "Value",
"text": [
"=1.5 ULN"
],
"offsets": [
[
911,
919
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T47",
"type": "Measurement",
"text": [
"creatinine clearance"
],
"offsets": [
[
921,
941
]
],
"normalized": []
},
{
"id": "NCT03196843_inc_T48",
"type": "Value",
"text": [
"= 50ml/min"
],
"offsets": [
[
945,
955
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03196843_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03196843_inc_T3",
"arg2_id": "NCT03196843_inc_T4",
"normalized": []
},
{
"id": "NCT03196843_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03196843_inc_T3",
"arg2_id": "NCT03196843_inc_T5",
"normalized": []
},
{
"id": "NCT03196843_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT03196843_inc_T5",
"arg2_id": "NCT03196843_inc_T10",
"normalized": []
},
{
"id": "NCT03196843_inc_R4",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T11",
"arg2_id": "NCT03196843_inc_T12",
"normalized": []
},
{
"id": "NCT03196843_inc_R5",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T13",
"arg2_id": "NCT03196843_inc_T14",
"normalized": []
},
{
"id": "NCT03196843_inc_R6",
"type": "AND",
"arg1_id": "NCT03196843_inc_T15",
"arg2_id": "NCT03196843_inc_T16",
"normalized": []
},
{
"id": "NCT03196843_inc_R7",
"type": "AND",
"arg1_id": "NCT03196843_inc_T17",
"arg2_id": "NCT03196843_inc_T18",
"normalized": []
},
{
"id": "NCT03196843_inc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT03196843_inc_T19",
"arg2_id": "NCT03196843_inc_T20",
"normalized": []
},
{
"id": "NCT03196843_inc_R9",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T23",
"arg2_id": "NCT03196843_inc_T22",
"normalized": []
},
{
"id": "NCT03196843_inc_R10",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T19",
"arg2_id": "NCT03196843_inc_T21",
"normalized": []
},
{
"id": "NCT03196843_inc_R11",
"type": "Has_negation",
"arg1_id": "NCT03196843_inc_T24",
"arg2_id": "NCT03196843_inc_T25",
"normalized": []
},
{
"id": "NCT03196843_inc_R12",
"type": "Has_mood",
"arg1_id": "NCT03196843_inc_T24",
"arg2_id": "NCT03196843_inc_T26",
"normalized": []
},
{
"id": "NCT03196843_inc_R13",
"type": "Has_negation",
"arg1_id": "NCT03196843_inc_T27",
"arg2_id": "NCT03196843_inc_T29",
"normalized": []
},
{
"id": "NCT03196843_inc_R14",
"type": "AND",
"arg1_id": "NCT03196843_inc_T27",
"arg2_id": "NCT03196843_inc_T28",
"normalized": []
},
{
"id": "NCT03196843_inc_R15",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T30",
"arg2_id": "NCT03196843_inc_T31",
"normalized": []
},
{
"id": "NCT03196843_inc_R16",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T38",
"arg2_id": "NCT03196843_inc_T39",
"normalized": []
},
{
"id": "NCT03196843_inc_R17",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T36",
"arg2_id": "NCT03196843_inc_T37",
"normalized": []
},
{
"id": "NCT03196843_inc_R18",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T34",
"arg2_id": "NCT03196843_inc_T35",
"normalized": []
},
{
"id": "NCT03196843_inc_R19",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T32",
"arg2_id": "NCT03196843_inc_T33",
"normalized": []
},
{
"id": "NCT03196843_inc_R20",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T41",
"arg2_id": "NCT03196843_inc_T42",
"normalized": []
},
{
"id": "NCT03196843_inc_R21",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T40",
"arg2_id": "NCT03196843_inc_T42",
"normalized": []
},
{
"id": "NCT03196843_inc_R22",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T43",
"arg2_id": "NCT03196843_inc_T44",
"normalized": []
},
{
"id": "NCT03196843_inc_R23",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T45",
"arg2_id": "NCT03196843_inc_T46",
"normalized": []
},
{
"id": "NCT03196843_inc_R24",
"type": "Has_value",
"arg1_id": "NCT03196843_inc_T47",
"arg2_id": "NCT03196843_inc_T48",
"normalized": []
}
] |
NCT03198910_exc | NCT03198910 | [
{
"id": "NCT03198910_exc_text",
"type": "exclusion",
"text": [
" \n"
],
"offsets": [
[
0,
5
]
]
}
] | [] | [] | [] | [] |
NCT03198910_inc | NCT03198910 | [
{
"id": "NCT03198910_inc_text",
"type": "inclusion",
"text": [
"Patients with pulmonary arterial hypertension (PAH) \nPatients with chronic thromboembolic pulmonary hypertension (CTEPH) \nAll prevalent patients (diagnosed >12 month ago) with PAH or distal CTEPH who had a consultation at the PH centre in Zurich between November 2015 and November 2016) \n"
],
"offsets": [
[
0,
288
]
]
}
] | [
{
"id": "NCT03198910_inc_T1",
"type": "Condition",
"text": [
"pulmonary arterial hypertension (PAH)"
],
"offsets": [
[
14,
51
]
],
"normalized": []
},
{
"id": "NCT03198910_inc_T2",
"type": "Condition",
"text": [
"chronic thromboembolic pulmonary hypertension (CTEPH)"
],
"offsets": [
[
67,
120
]
],
"normalized": []
},
{
"id": "NCT03198910_inc_T3",
"type": "Temporal",
"text": [
">12 month ago"
],
"offsets": [
[
156,
169
]
],
"normalized": []
},
{
"id": "NCT03198910_inc_T4",
"type": "Condition",
"text": [
"PAH"
],
"offsets": [
[
176,
179
]
],
"normalized": []
},
{
"id": "NCT03198910_inc_T5",
"type": "Condition",
"text": [
"CTEPH"
],
"offsets": [
[
190,
195
]
],
"normalized": []
},
{
"id": "NCT03198910_inc_T6",
"type": "Qualifier",
"text": [
"distal"
],
"offsets": [
[
183,
189
]
],
"normalized": []
},
{
"id": "NCT03198910_inc_T8",
"type": "Visit",
"text": [
"Zurich"
],
"offsets": [
[
239,
245
]
],
"normalized": []
},
{
"id": "NCT03198910_inc_T9",
"type": "Temporal",
"text": [
"between November 2015 and November 2016"
],
"offsets": [
[
246,
285
]
],
"normalized": []
},
{
"id": "NCT03198910_inc_T10",
"type": "Visit",
"text": [
"consultation at the PH centre"
],
"offsets": [
[
206,
235
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03198910_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03198910_inc_T5",
"arg2_id": "NCT03198910_inc_T6",
"normalized": []
}
] |
NCT03199560_exc | NCT03199560 | [
{
"id": "NCT03199560_exc_text",
"type": "exclusion",
"text": [
"Women under the age of 18,\nClinically positive axillary nodes\nNeoadjuvant therapy for current breast cancer diagnosis\nWomen with previous SLNBx or axillary node dissection\nPregnant women\nWomen with previous radiation above the diaphragm, and below the neck\n"
],
"offsets": [
[
0,
257
]
]
}
] | [
{
"id": "NCT03199560_exc_T1",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T2",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
16,
19
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T3",
"type": "Value",
"text": [
"18",
"under"
],
"offsets": [
[
23,
25
],
[
6,
11
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T4",
"type": "Condition",
"text": [
"axillary nodes"
],
"offsets": [
[
47,
61
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T5",
"type": "Qualifier",
"text": [
"positive"
],
"offsets": [
[
38,
46
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T6",
"type": "Procedure",
"text": [
"Neoadjuvant therapy"
],
"offsets": [
[
62,
81
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T7",
"type": "Condition",
"text": [
"breast cancer"
],
"offsets": [
[
94,
107
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T8",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
118,
123
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T9",
"type": "Procedure",
"text": [
"SLNBx"
],
"offsets": [
[
138,
143
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T10",
"type": "Procedure",
"text": [
"axillary node dissection"
],
"offsets": [
[
147,
171
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T11",
"type": "Qualifier",
"text": [
"previous"
],
"offsets": [
[
129,
137
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T12",
"type": "Scope",
"text": [
"SLNBx or axillary node dissection"
],
"offsets": [
[
138,
171
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T14",
"type": "Procedure",
"text": [
"radiation"
],
"offsets": [
[
207,
216
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T15",
"type": "Qualifier",
"text": [
"above the diaphragm"
],
"offsets": [
[
217,
236
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T16",
"type": "Qualifier",
"text": [
"below the neck"
],
"offsets": [
[
242,
256
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T17",
"type": "Qualifier",
"text": [
"previous"
],
"offsets": [
[
198,
206
]
],
"normalized": []
},
{
"id": "NCT03199560_exc_T18",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
187,
192
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03199560_exc_R1",
"type": "Has_value",
"arg1_id": "NCT03199560_exc_T2",
"arg2_id": "NCT03199560_exc_T3",
"normalized": []
},
{
"id": "NCT03199560_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03199560_exc_T4",
"arg2_id": "NCT03199560_exc_T5",
"normalized": []
},
{
"id": "NCT03199560_exc_R3",
"type": "AND",
"arg1_id": "NCT03199560_exc_T6",
"arg2_id": "NCT03199560_exc_T7",
"normalized": []
},
{
"id": "NCT03199560_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT03199560_exc_T12",
"arg2_id": "NCT03199560_exc_T11",
"normalized": []
},
{
"id": "NCT03199560_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT03199560_exc_T14",
"arg2_id": "NCT03199560_exc_T15",
"normalized": []
},
{
"id": "NCT03199560_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT03199560_exc_T14",
"arg2_id": "NCT03199560_exc_T16",
"normalized": []
},
{
"id": "NCT03199560_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT03199560_exc_T14",
"arg2_id": "NCT03199560_exc_T17",
"normalized": []
}
] |
NCT03199560_inc | NCT03199560 | [
{
"id": "NCT03199560_inc_text",
"type": "inclusion",
"text": [
"Women above 18 years of age with biopsy proven, clinically stage 1 or 2 breast cancer who will be undergoing partial mastectomy with SLNBx at Memorial Health\n"
],
"offsets": [
[
0,
158
]
]
}
] | [
{
"id": "NCT03199560_inc_T1",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT03199560_inc_T2",
"type": "Value",
"text": [
"above 18 years"
],
"offsets": [
[
6,
20
]
],
"normalized": []
},
{
"id": "NCT03199560_inc_T3",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
24,
27
]
],
"normalized": []
},
{
"id": "NCT03199560_inc_T4",
"type": "Condition",
"text": [
"breast cancer"
],
"offsets": [
[
72,
85
]
],
"normalized": []
},
{
"id": "NCT03199560_inc_T5",
"type": "Qualifier",
"text": [
"stage 1"
],
"offsets": [
[
59,
66
]
],
"normalized": []
},
{
"id": "NCT03199560_inc_T6",
"type": "Qualifier",
"text": [
"stage",
"2"
],
"offsets": [
[
59,
64
],
[
70,
71
]
],
"normalized": []
},
{
"id": "NCT03199560_inc_T7",
"type": "Procedure",
"text": [
"biopsy"
],
"offsets": [
[
33,
39
]
],
"normalized": []
},
{
"id": "NCT03199560_inc_T8",
"type": "Scope",
"text": [
"stage 1 or 2"
],
"offsets": [
[
59,
71
]
],
"normalized": []
},
{
"id": "NCT03199560_inc_T9",
"type": "Procedure",
"text": [
"partial mastectomy"
],
"offsets": [
[
109,
127
]
],
"normalized": []
},
{
"id": "NCT03199560_inc_T10",
"type": "Procedure",
"text": [
"SLNBx"
],
"offsets": [
[
133,
138
]
],
"normalized": []
},
{
"id": "NCT03199560_inc_T11",
"type": "Visit",
"text": [
"at Memorial Health"
],
"offsets": [
[
139,
157
]
],
"normalized": []
},
{
"id": "NCT03199560_inc_T12",
"type": "Mood",
"text": [
"will be undergoing"
],
"offsets": [
[
90,
108
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03199560_inc_R1",
"type": "AND",
"arg1_id": "NCT03199560_inc_T2",
"arg2_id": "NCT03199560_inc_T3",
"normalized": []
},
{
"id": "NCT03199560_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT03199560_inc_T4",
"arg2_id": "NCT03199560_inc_T8",
"normalized": []
},
{
"id": "NCT03199560_inc_R3",
"type": "AND",
"arg1_id": "NCT03199560_inc_T7",
"arg2_id": "NCT03199560_inc_T4",
"normalized": []
},
{
"id": "NCT03199560_inc_R4",
"type": "AND",
"arg1_id": "NCT03199560_inc_T9",
"arg2_id": "NCT03199560_inc_T10",
"normalized": []
},
{
"id": "NCT03199560_inc_R5",
"type": "Has_mood",
"arg1_id": "NCT03199560_inc_T9",
"arg2_id": "NCT03199560_inc_T12",
"normalized": []
},
{
"id": "NCT03199560_inc_R6",
"type": "AND",
"arg1_id": "NCT03199560_inc_T4",
"arg2_id": "NCT03199560_inc_T9",
"normalized": []
}
] |
NCT03208127_exc | NCT03208127 | [
{
"id": "NCT03208127_exc_text",
"type": "exclusion",
"text": [
"Pregnant or nursing (lactating) women\nHIV positivity\nNeed for dual organ transplant\nAny contra-indication to liver transplantation per center protocol\n"
],
"offsets": [
[
0,
151
]
]
}
] | [
{
"id": "NCT03208127_exc_T1",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
0,
8
]
],
"normalized": []
},
{
"id": "NCT03208127_exc_T2",
"type": "Observation",
"text": [
"nursing"
],
"offsets": [
[
12,
19
]
],
"normalized": []
},
{
"id": "NCT03208127_exc_T3",
"type": "Observation",
"text": [
"lactating"
],
"offsets": [
[
21,
30
]
],
"normalized": []
},
{
"id": "NCT03208127_exc_T4",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
32,
37
]
],
"normalized": []
},
{
"id": "NCT03208127_exc_T5",
"type": "Condition",
"text": [
"HIV positivity"
],
"offsets": [
[
38,
52
]
],
"normalized": []
},
{
"id": "NCT03208127_exc_T6",
"type": "Measurement",
"text": [
"HIV"
],
"offsets": [
[
38,
41
]
],
"normalized": []
},
{
"id": "NCT03208127_exc_T7",
"type": "Value",
"text": [
"positivity"
],
"offsets": [
[
42,
52
]
],
"normalized": []
},
{
"id": "NCT03208127_exc_T8",
"type": "Procedure",
"text": [
"dual organ transplant"
],
"offsets": [
[
62,
83
]
],
"normalized": []
},
{
"id": "NCT03208127_exc_T9",
"type": "Mood",
"text": [
"Need for"
],
"offsets": [
[
53,
61
]
],
"normalized": []
},
{
"id": "NCT03208127_exc_T10",
"type": "Condition",
"text": [
"contra-indication"
],
"offsets": [
[
88,
105
]
],
"normalized": []
},
{
"id": "NCT03208127_exc_T11",
"type": "Procedure",
"text": [
"liver transplantation"
],
"offsets": [
[
109,
130
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03208127_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT03208127_exc_T2",
"arg2_id": "NCT03208127_exc_T3",
"normalized": []
},
{
"id": "NCT03208127_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03208127_exc_T6",
"arg2_id": "NCT03208127_exc_T7",
"normalized": []
},
{
"id": "NCT03208127_exc_R4",
"type": "Has_mood",
"arg1_id": "NCT03208127_exc_T8",
"arg2_id": "NCT03208127_exc_T9",
"normalized": []
},
{
"id": "NCT03208127_exc_R5",
"type": "AND",
"arg1_id": "NCT03208127_exc_T10",
"arg2_id": "NCT03208127_exc_T11",
"normalized": []
}
] |
NCT03208127_inc | NCT03208127 | [
{
"id": "NCT03208127_inc_text",
"type": "inclusion",
"text": [
"Recipient is Age = 18 years\nMet MGH transplant center criteria, listed for liver transplant\nHCV naive\nAble to sign informed consent\n"
],
"offsets": [
[
0,
132
]
]
}
] | [
{
"id": "NCT03208127_inc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
13,
16
]
],
"normalized": []
},
{
"id": "NCT03208127_inc_T2",
"type": "Value",
"text": [
"= 18 years"
],
"offsets": [
[
17,
27
]
],
"normalized": []
},
{
"id": "NCT03208127_inc_T3",
"type": "Qualifier",
"text": [
"MGH transplant center criteria"
],
"offsets": [
[
32,
62
]
],
"normalized": []
},
{
"id": "NCT03208127_inc_T4",
"type": "Procedure",
"text": [
"liver transplant"
],
"offsets": [
[
75,
91
]
],
"normalized": []
},
{
"id": "NCT03208127_inc_T5",
"type": "Measurement",
"text": [
"HCV"
],
"offsets": [
[
92,
95
]
],
"normalized": []
},
{
"id": "NCT03208127_inc_T6",
"type": "Value",
"text": [
"naive"
],
"offsets": [
[
96,
101
]
],
"normalized": []
},
{
"id": "NCT03208127_inc_T7",
"type": "Condition",
"text": [
"HCV naive"
],
"offsets": [
[
92,
101
]
],
"normalized": []
},
{
"id": "NCT03208127_inc_T8",
"type": "Observation",
"text": [
"Able to sign informed consent"
],
"offsets": [
[
102,
131
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03208127_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03208127_inc_T1",
"arg2_id": "NCT03208127_inc_T2",
"normalized": []
},
{
"id": "NCT03208127_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03208127_inc_T4",
"arg2_id": "NCT03208127_inc_T3",
"normalized": []
},
{
"id": "NCT03208127_inc_R3",
"type": "Has_value",
"arg1_id": "NCT03208127_inc_T5",
"arg2_id": "NCT03208127_inc_T6",
"normalized": []
}
] |
NCT03208244_exc | NCT03208244 | [
{
"id": "NCT03208244_exc_text",
"type": "exclusion",
"text": [
"Sensitization (i.e. PRA >20%)\nAny liver disease in recipient\nAlbumin < 3g/dl or platelet count < 75 x 103/mL\nNeed for dual organ transplant\n"
],
"offsets": [
[
0,
140
]
]
}
] | [
{
"id": "NCT03208244_exc_T1",
"type": "Condition",
"text": [
"Sensitization"
],
"offsets": [
[
0,
13
]
],
"normalized": []
},
{
"id": "NCT03208244_exc_T2",
"type": "Measurement",
"text": [
"PRA"
],
"offsets": [
[
20,
23
]
],
"normalized": []
},
{
"id": "NCT03208244_exc_T3",
"type": "Value",
"text": [
">20%"
],
"offsets": [
[
24,
28
]
],
"normalized": []
},
{
"id": "NCT03208244_exc_T4",
"type": "Scope",
"text": [
"PRA >20%"
],
"offsets": [
[
20,
28
]
],
"normalized": []
},
{
"id": "NCT03208244_exc_T5",
"type": "Condition",
"text": [
"liver disease"
],
"offsets": [
[
34,
47
]
],
"normalized": []
},
{
"id": "NCT03208244_exc_T6",
"type": "Measurement",
"text": [
"Albumin"
],
"offsets": [
[
61,
68
]
],
"normalized": []
},
{
"id": "NCT03208244_exc_T7",
"type": "Value",
"text": [
"< 3g/dl"
],
"offsets": [
[
69,
76
]
],
"normalized": []
},
{
"id": "NCT03208244_exc_T8",
"type": "Measurement",
"text": [
"platelet count"
],
"offsets": [
[
80,
94
]
],
"normalized": []
},
{
"id": "NCT03208244_exc_T9",
"type": "Value",
"text": [
"< 75 x 103/mL"
],
"offsets": [
[
95,
108
]
],
"normalized": []
},
{
"id": "NCT03208244_exc_T10",
"type": "Measurement",
"text": [
"dual organ transplant"
],
"offsets": [
[
118,
139
]
],
"normalized": []
},
{
"id": "NCT03208244_exc_T11",
"type": "Mood",
"text": [
"Need for"
],
"offsets": [
[
109,
117
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03208244_exc_R1",
"type": "Has_value",
"arg1_id": "NCT03208244_exc_T2",
"arg2_id": "NCT03208244_exc_T3",
"normalized": []
},
{
"id": "NCT03208244_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT03208244_exc_T1",
"arg2_id": "NCT03208244_exc_T4",
"normalized": []
},
{
"id": "NCT03208244_exc_R3",
"type": "Has_value",
"arg1_id": "NCT03208244_exc_T8",
"arg2_id": "NCT03208244_exc_T9",
"normalized": []
},
{
"id": "NCT03208244_exc_R4",
"type": "Has_value",
"arg1_id": "NCT03208244_exc_T6",
"arg2_id": "NCT03208244_exc_T7",
"normalized": []
},
{
"id": "NCT03208244_exc_R5",
"type": "Has_mood",
"arg1_id": "NCT03208244_exc_T10",
"arg2_id": "NCT03208244_exc_T11",
"normalized": []
}
] |
NCT03208244_inc | NCT03208244 | [
{
"id": "NCT03208244_inc_text",
"type": "inclusion",
"text": [
"Recipient is Age = 18 years\nSerum ALT within normal limits with no history of liver disease\nLack of sensitization (i.e. PRA < 20%) that would be expected to result in a high likelihood of needing aggressive immunosuppression to treat rejection\n"
],
"offsets": [
[
0,
244
]
]
}
] | [
{
"id": "NCT03208244_inc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
13,
16
]
],
"normalized": []
},
{
"id": "NCT03208244_inc_T2",
"type": "Value",
"text": [
"= 18 years"
],
"offsets": [
[
17,
27
]
],
"normalized": []
},
{
"id": "NCT03208244_inc_T3",
"type": "Measurement",
"text": [
"Serum ALT"
],
"offsets": [
[
28,
37
]
],
"normalized": []
},
{
"id": "NCT03208244_inc_T4",
"type": "Value",
"text": [
"within normal limits"
],
"offsets": [
[
38,
58
]
],
"normalized": []
},
{
"id": "NCT03208244_inc_T5",
"type": "Negation",
"text": [
"no"
],
"offsets": [
[
64,
66
]
],
"normalized": []
},
{
"id": "NCT03208244_inc_T6",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
67,
74
]
],
"normalized": []
},
{
"id": "NCT03208244_inc_T7",
"type": "Condition",
"text": [
"liver disease"
],
"offsets": [
[
78,
91
]
],
"normalized": []
},
{
"id": "NCT03208244_inc_T8",
"type": "Negation",
"text": [
"Lack of"
],
"offsets": [
[
92,
99
]
],
"normalized": []
},
{
"id": "NCT03208244_inc_T9",
"type": "Condition",
"text": [
"sensitization"
],
"offsets": [
[
100,
113
]
],
"normalized": []
},
{
"id": "NCT03208244_inc_T10",
"type": "Measurement",
"text": [
"PRA"
],
"offsets": [
[
120,
123
]
],
"normalized": []
},
{
"id": "NCT03208244_inc_T11",
"type": "Value",
"text": [
"< 20%"
],
"offsets": [
[
124,
129
]
],
"normalized": []
},
{
"id": "NCT03208244_inc_T12",
"type": "Scope",
"text": [
"PRA < 20%"
],
"offsets": [
[
120,
129
]
],
"normalized": []
},
{
"id": "NCT03208244_inc_T13",
"type": "Scope",
"text": [
"sensitization (i.e. PRA < 20%)"
],
"offsets": [
[
100,
130
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03208244_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03208244_inc_T1",
"arg2_id": "NCT03208244_inc_T2",
"normalized": []
},
{
"id": "NCT03208244_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03208244_inc_T3",
"arg2_id": "NCT03208244_inc_T4",
"normalized": []
},
{
"id": "NCT03208244_inc_R3",
"type": "Has_negation",
"arg1_id": "NCT03208244_inc_T7",
"arg2_id": "NCT03208244_inc_T5",
"normalized": []
},
{
"id": "NCT03208244_inc_R4",
"type": "Has_temporal",
"arg1_id": "NCT03208244_inc_T7",
"arg2_id": "NCT03208244_inc_T6",
"normalized": []
},
{
"id": "NCT03208244_inc_R5",
"type": "Has_value",
"arg1_id": "NCT03208244_inc_T10",
"arg2_id": "NCT03208244_inc_T11",
"normalized": []
},
{
"id": "NCT03208244_inc_R6",
"type": "Has_scope",
"arg1_id": "NCT03208244_inc_T9",
"arg2_id": "NCT03208244_inc_T12",
"normalized": []
},
{
"id": "NCT03208244_inc_R7",
"type": "Has_negation",
"arg1_id": "NCT03208244_inc_T13",
"arg2_id": "NCT03208244_inc_T8",
"normalized": []
}
] |
NCT03208465_exc | NCT03208465 | [
{
"id": "NCT03208465_exc_text",
"type": "exclusion",
"text": [
"Contraindications to empagliflozin, Sitagliptin\nDPP4 inhibitors or Sodium-glucose cotransporter-2(SGLT2) inhibitors within the previous 4 weeks\nInsulin requiring diabetes\nPoor glucose control (HbA1C>10 %)\nAcute coronary syndrome\nStent placement within the previous 6 months\nPrevious coronary artery bypass graft surgery within the previous 6 months\nPlanned revascularization within 6 months\nHeart failure requiring loop diuretics\nSevere left ventricular hypertrophy (left ventricular septal wall thickness > 13mm)\nSignificant renal disease manifested by creatinine clearance of < 30 ml/min)\nHepatic disease or biliary tract obstruction, or significant hepatic enzyme elevation (alanine transaminase or Aspartate Aminotransferase > 3 times upper limit of normal)\nRadiopaque material implanted in the chest wall (metal, silicone, etc.)\nContraindication to adenosine stress test\nAny clinically significant abnormality identified at the screening visit, physical examination, laboratory tests, or electrocardiogram which, in the judgment of the Investigator, would preclude safe completion of the study.\nPatient's pregnant or breast-feeding or child-bearing potential\nExpected life expectancy < 1 year\nUnwillingness or inability to comply with the procedures described in this protocol\n"
],
"offsets": [
[
0,
1282
]
]
}
] | [
{
"id": "NCT03208465_exc_T1",
"type": "Condition",
"text": [
"Contraindications"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T2",
"type": "Drug",
"text": [
"empagliflozin"
],
"offsets": [
[
21,
34
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T3",
"type": "Drug",
"text": [
"Sitagliptin"
],
"offsets": [
[
36,
47
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T4",
"type": "Scope",
"text": [
"empagliflozin, Sitagliptin"
],
"offsets": [
[
21,
47
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T5",
"type": "Drug",
"text": [
"DPP4 inhibitors"
],
"offsets": [
[
48,
63
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T6",
"type": "Drug",
"text": [
"Sodium-glucose cotransporter-2(SGLT2) inhibitors"
],
"offsets": [
[
67,
115
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T7",
"type": "Temporal",
"text": [
"within the previous 4 weeks"
],
"offsets": [
[
116,
143
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T8",
"type": "Scope",
"text": [
"DPP4 inhibitors or Sodium-glucose cotransporter-2(SGLT2) inhibitors"
],
"offsets": [
[
48,
115
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T9",
"type": "Drug",
"text": [
"Insulin"
],
"offsets": [
[
144,
151
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T10",
"type": "Procedure",
"text": [
"diabetes"
],
"offsets": [
[
162,
170
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T11",
"type": "Condition",
"text": [
"Poor glucose control"
],
"offsets": [
[
171,
191
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T12",
"type": "Measurement",
"text": [
"HbA1C"
],
"offsets": [
[
193,
198
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T13",
"type": "Value",
"text": [
">10 %"
],
"offsets": [
[
198,
203
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T14",
"type": "Scope",
"text": [
"HbA1C>10 %"
],
"offsets": [
[
193,
203
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T15",
"type": "Condition",
"text": [
"Acute coronary syndrome"
],
"offsets": [
[
205,
228
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T16",
"type": "Device",
"text": [
"Stent"
],
"offsets": [
[
229,
234
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T17",
"type": "Procedure",
"text": [
"placement"
],
"offsets": [
[
235,
244
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T18",
"type": "Temporal",
"text": [
"within the previous 6 months"
],
"offsets": [
[
245,
273
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T19",
"type": "Temporal",
"text": [
"within the previous 6 months"
],
"offsets": [
[
320,
348
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T20",
"type": "Procedure",
"text": [
"coronary artery bypass graft surgery"
],
"offsets": [
[
283,
319
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T21",
"type": "Temporal",
"text": [
"Previous"
],
"offsets": [
[
274,
282
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T22",
"type": "Procedure",
"text": [
"revascularization"
],
"offsets": [
[
357,
374
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T23",
"type": "Temporal",
"text": [
"within 6 months"
],
"offsets": [
[
375,
390
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T24",
"type": "Mood",
"text": [
"Planned"
],
"offsets": [
[
349,
356
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T25",
"type": "Condition",
"text": [
"Heart failure"
],
"offsets": [
[
391,
404
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T26",
"type": "Drug",
"text": [
"loop diuretics"
],
"offsets": [
[
415,
429
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T27",
"type": "Condition",
"text": [
"left ventricular hypertrophy"
],
"offsets": [
[
437,
465
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T28",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
430,
436
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T29",
"type": "Measurement",
"text": [
"left ventricular septal wall thickness"
],
"offsets": [
[
467,
505
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T30",
"type": "Value",
"text": [
"> 13mm"
],
"offsets": [
[
506,
512
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T31",
"type": "Scope",
"text": [
"Severe left ventricular hypertrophy"
],
"offsets": [
[
430,
465
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T32",
"type": "Scope",
"text": [
"left ventricular septal wall thickness > 13mm"
],
"offsets": [
[
467,
512
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T33",
"type": "Qualifier",
"text": [
"Significant"
],
"offsets": [
[
514,
525
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T34",
"type": "Condition",
"text": [
"renal disease"
],
"offsets": [
[
526,
539
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T35",
"type": "Measurement",
"text": [
"creatinine clearance"
],
"offsets": [
[
554,
574
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T36",
"type": "Value",
"text": [
"< 30 ml/min"
],
"offsets": [
[
578,
589
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T37",
"type": "Scope",
"text": [
"Significant renal disease"
],
"offsets": [
[
514,
539
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T38",
"type": "Scope",
"text": [
"creatinine clearance of < 30 ml/min"
],
"offsets": [
[
554,
589
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T39",
"type": "Condition",
"text": [
"Hepatic disease"
],
"offsets": [
[
591,
606
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T40",
"type": "Condition",
"text": [
"biliary tract obstruction"
],
"offsets": [
[
610,
635
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T41",
"type": "Condition",
"text": [
"hepatic enzyme elevation"
],
"offsets": [
[
652,
676
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T42",
"type": "Qualifier",
"text": [
"significant"
],
"offsets": [
[
640,
651
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T43",
"type": "Measurement",
"text": [
"alanine transaminase"
],
"offsets": [
[
678,
698
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T44",
"type": "Measurement",
"text": [
"Aspartate Aminotransferase"
],
"offsets": [
[
702,
728
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T45",
"type": "Value",
"text": [
"> 3 times upper limit of normal"
],
"offsets": [
[
729,
760
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T46",
"type": "Scope",
"text": [
"alanine transaminase or Aspartate Aminotransferase"
],
"offsets": [
[
678,
728
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T47",
"type": "Scope",
"text": [
"alanine transaminase or Aspartate Aminotransferase > 3 times upper limit of normal"
],
"offsets": [
[
678,
760
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T48",
"type": "Device",
"text": [
"Radiopaque material"
],
"offsets": [
[
762,
781
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T49",
"type": "Qualifier",
"text": [
"chest wall"
],
"offsets": [
[
799,
809
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T50",
"type": "Procedure",
"text": [
"adenosine stress test"
],
"offsets": [
[
854,
875
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T51",
"type": "Condition",
"text": [
"Contraindication"
],
"offsets": [
[
834,
850
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T53",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
1110,
1118
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T54",
"type": "Condition",
"text": [
"breast-feeding"
],
"offsets": [
[
1122,
1136
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T55",
"type": "Condition",
"text": [
"child-bearing potential"
],
"offsets": [
[
1140,
1163
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T56",
"type": "Observation",
"text": [
"Expected life expectancy"
],
"offsets": [
[
1164,
1188
]
],
"normalized": []
},
{
"id": "NCT03208465_exc_T57",
"type": "Value",
"text": [
"< 1 year"
],
"offsets": [
[
1189,
1197
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03208465_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT03208465_exc_T1",
"arg2_id": "NCT03208465_exc_T4",
"normalized": []
},
{
"id": "NCT03208465_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT03208465_exc_T8",
"arg2_id": "NCT03208465_exc_T7",
"normalized": []
},
{
"id": "NCT03208465_exc_R3",
"type": "AND",
"arg1_id": "NCT03208465_exc_T10",
"arg2_id": "NCT03208465_exc_T9",
"normalized": []
},
{
"id": "NCT03208465_exc_R4",
"type": "Has_value",
"arg1_id": "NCT03208465_exc_T12",
"arg2_id": "NCT03208465_exc_T13",
"normalized": []
},
{
"id": "NCT03208465_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT03208465_exc_T11",
"arg2_id": "NCT03208465_exc_T14",
"normalized": []
},
{
"id": "NCT03208465_exc_R6",
"type": "AND",
"arg1_id": "NCT03208465_exc_T17",
"arg2_id": "NCT03208465_exc_T16",
"normalized": []
},
{
"id": "NCT03208465_exc_R7",
"type": "Has_temporal",
"arg1_id": "NCT03208465_exc_T17",
"arg2_id": "NCT03208465_exc_T18",
"normalized": []
},
{
"id": "NCT03208465_exc_R8",
"type": "Has_temporal",
"arg1_id": "NCT03208465_exc_T20",
"arg2_id": "NCT03208465_exc_T19",
"normalized": []
},
{
"id": "NCT03208465_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT03208465_exc_T20",
"arg2_id": "NCT03208465_exc_T21",
"normalized": []
},
{
"id": "NCT03208465_exc_R10",
"type": "Has_temporal",
"arg1_id": "NCT03208465_exc_T22",
"arg2_id": "NCT03208465_exc_T23",
"normalized": []
},
{
"id": "NCT03208465_exc_R11",
"type": "Has_mood",
"arg1_id": "NCT03208465_exc_T22",
"arg2_id": "NCT03208465_exc_T24",
"normalized": []
},
{
"id": "NCT03208465_exc_R12",
"type": "AND",
"arg1_id": "NCT03208465_exc_T25",
"arg2_id": "NCT03208465_exc_T26",
"normalized": []
},
{
"id": "NCT03208465_exc_R13",
"type": "Has_qualifier",
"arg1_id": "NCT03208465_exc_T27",
"arg2_id": "NCT03208465_exc_T28",
"normalized": []
},
{
"id": "NCT03208465_exc_R14",
"type": "Subsumes",
"arg1_id": "NCT03208465_exc_T31",
"arg2_id": "NCT03208465_exc_T32",
"normalized": []
},
{
"id": "NCT03208465_exc_R15",
"type": "Has_value",
"arg1_id": "NCT03208465_exc_T35",
"arg2_id": "NCT03208465_exc_T36",
"normalized": []
},
{
"id": "NCT03208465_exc_R16",
"type": "Has_qualifier",
"arg1_id": "NCT03208465_exc_T34",
"arg2_id": "NCT03208465_exc_T33",
"normalized": []
},
{
"id": "NCT03208465_exc_R17",
"type": "Subsumes",
"arg1_id": "NCT03208465_exc_T37",
"arg2_id": "NCT03208465_exc_T38",
"normalized": []
},
{
"id": "NCT03208465_exc_R18",
"type": "Has_qualifier",
"arg1_id": "NCT03208465_exc_T41",
"arg2_id": "NCT03208465_exc_T42",
"normalized": []
},
{
"id": "NCT03208465_exc_R19",
"type": "Has_value",
"arg1_id": "NCT03208465_exc_T46",
"arg2_id": "NCT03208465_exc_T45",
"normalized": []
},
{
"id": "NCT03208465_exc_R20",
"type": "Has_qualifier",
"arg1_id": "NCT03208465_exc_T48",
"arg2_id": "NCT03208465_exc_T49",
"normalized": []
},
{
"id": "NCT03208465_exc_R21",
"type": "AND",
"arg1_id": "NCT03208465_exc_T51",
"arg2_id": "NCT03208465_exc_T50",
"normalized": []
},
{
"id": "NCT03208465_exc_R22",
"type": "Has_value",
"arg1_id": "NCT03208465_exc_T56",
"arg2_id": "NCT03208465_exc_T57",
"normalized": []
}
] |
NCT03208465_inc | NCT03208465 | [
{
"id": "NCT03208465_inc_text",
"type": "inclusion",
"text": [
"Men or women at least 19 years of age\nType 2 diabetes mellitus\nStable coronary artery disease\nGlobal myocardial perfusion reserve (MPR) index < 2.5\nThe patient or guardian agrees to the study protocol and the schedule of clinical and dynamic SPECT follow-up, and provides informed, written consent, as approved by the appropriate Institutional Review Board/Ethical Committee of the respective clinical site.\n"
],
"offsets": [
[
0,
408
]
]
}
] | [
{
"id": "NCT03208465_inc_T1",
"type": "Person",
"text": [
"Men"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT03208465_inc_T2",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
7,
12
]
],
"normalized": []
},
{
"id": "NCT03208465_inc_T3",
"type": "Value",
"text": [
"at least 19 years"
],
"offsets": [
[
13,
30
]
],
"normalized": []
},
{
"id": "NCT03208465_inc_T4",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
34,
37
]
],
"normalized": []
},
{
"id": "NCT03208465_inc_T5",
"type": "Condition",
"text": [
"Type 2 diabetes mellitus"
],
"offsets": [
[
38,
62
]
],
"normalized": []
},
{
"id": "NCT03208465_inc_T6",
"type": "Condition",
"text": [
"coronary artery disease"
],
"offsets": [
[
70,
93
]
],
"normalized": []
},
{
"id": "NCT03208465_inc_T7",
"type": "Qualifier",
"text": [
"Stable"
],
"offsets": [
[
63,
69
]
],
"normalized": []
},
{
"id": "NCT03208465_inc_T8",
"type": "Measurement",
"text": [
"Global myocardial perfusion reserve (MPR) index"
],
"offsets": [
[
94,
141
]
],
"normalized": []
},
{
"id": "NCT03208465_inc_T10",
"type": "Value",
"text": [
"< 2.5"
],
"offsets": [
[
142,
147
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03208465_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03208465_inc_T4",
"arg2_id": "NCT03208465_inc_T3",
"normalized": []
},
{
"id": "NCT03208465_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03208465_inc_T6",
"arg2_id": "NCT03208465_inc_T7",
"normalized": []
},
{
"id": "NCT03208465_inc_R3",
"type": "Has_value",
"arg1_id": "NCT03208465_inc_T8",
"arg2_id": "NCT03208465_inc_T10",
"normalized": []
}
] |
NCT03208998_exc | NCT03208998 | [
{
"id": "NCT03208998_exc_text",
"type": "exclusion",
"text": [
"Active consumption of alcohol and/or drugs\nCo-infection with human immunodeficiency virus, hepatitis C virus, or hepatitis D virus\nHistory of autoimmune hepatitis\nPsychiatric disease\nEvidence of neoplastic diseases of the liver\n"
],
"offsets": [
[
0,
228
]
]
}
] | [
{
"id": "NCT03208998_exc_T1",
"type": "Condition",
"text": [
"consumption of alcohol"
],
"offsets": [
[
7,
29
]
],
"normalized": []
},
{
"id": "NCT03208998_exc_T2",
"type": "Condition",
"text": [
"drugs",
"consumption of"
],
"offsets": [
[
37,
42
],
[
7,
21
]
],
"normalized": []
},
{
"id": "NCT03208998_exc_T3",
"type": "Qualifier",
"text": [
"Active"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "NCT03208998_exc_T4",
"type": "Scope",
"text": [
"consumption of alcohol and/or drugs"
],
"offsets": [
[
7,
42
]
],
"normalized": []
},
{
"id": "NCT03208998_exc_T5",
"type": "Condition",
"text": [
"human immunodeficiency virus"
],
"offsets": [
[
61,
89
]
],
"normalized": []
},
{
"id": "NCT03208998_exc_T6",
"type": "Condition",
"text": [
"hepatitis C virus"
],
"offsets": [
[
91,
108
]
],
"normalized": []
},
{
"id": "NCT03208998_exc_T7",
"type": "Condition",
"text": [
"hepatitis D virus"
],
"offsets": [
[
113,
130
]
],
"normalized": []
},
{
"id": "NCT03208998_exc_T8",
"type": "Condition",
"text": [
"autoimmune hepatitis"
],
"offsets": [
[
142,
162
]
],
"normalized": []
},
{
"id": "NCT03208998_exc_T9",
"type": "Condition",
"text": [
"Psychiatric disease"
],
"offsets": [
[
163,
182
]
],
"normalized": []
},
{
"id": "NCT03208998_exc_T10",
"type": "Condition",
"text": [
"neoplastic diseases"
],
"offsets": [
[
195,
214
]
],
"normalized": []
},
{
"id": "NCT03208998_exc_T11",
"type": "Qualifier",
"text": [
"liver"
],
"offsets": [
[
222,
227
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03208998_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03208998_exc_T4",
"arg2_id": "NCT03208998_exc_T3",
"normalized": []
},
{
"id": "NCT03208998_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03208998_exc_T10",
"arg2_id": "NCT03208998_exc_T11",
"normalized": []
}
] |
NCT03208998_inc | NCT03208998 | [
{
"id": "NCT03208998_inc_text",
"type": "inclusion",
"text": [
"HBsAg and HBeAg positive for more than 6 months, HBV DNA detectable with ALT level abnormal lasted for three months and at least time190 IU/L or liver puncture biopsy demonstrated apparent inflammation, never treated before enrolled.\n"
],
"offsets": [
[
0,
234
]
]
}
] | [
{
"id": "NCT03208998_inc_T1",
"type": "Condition",
"text": [
"HBeAg positive"
],
"offsets": [
[
10,
24
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T2",
"type": "Condition",
"text": [
"HBsAg",
"positive"
],
"offsets": [
[
0,
5
],
[
16,
24
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T3",
"type": "Temporal",
"text": [
"for more than 6 months"
],
"offsets": [
[
25,
47
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T4",
"type": "Scope",
"text": [
"HBsAg and HBeAg positive"
],
"offsets": [
[
0,
24
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T5",
"type": "Condition",
"text": [
"HBV DNA detectable"
],
"offsets": [
[
49,
67
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T6",
"type": "Measurement",
"text": [
"ALT level"
],
"offsets": [
[
73,
82
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T7",
"type": "Value",
"text": [
"abnormal"
],
"offsets": [
[
83,
91
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T8",
"type": "Temporal",
"text": [
"lasted for three months"
],
"offsets": [
[
92,
115
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T9",
"type": "Temporal",
"text": [
"at least time"
],
"offsets": [
[
120,
133
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T10",
"type": "Value",
"text": [
"190 IU/L"
],
"offsets": [
[
133,
141
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T11",
"type": "Procedure",
"text": [
"liver puncture biopsy"
],
"offsets": [
[
145,
166
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T12",
"type": "Condition",
"text": [
"inflammation"
],
"offsets": [
[
189,
201
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T13",
"type": "Negation",
"text": [
"never"
],
"offsets": [
[
203,
208
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T14",
"type": "Procedure",
"text": [
"treated"
],
"offsets": [
[
209,
216
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T15",
"type": "Temporal",
"text": [
"before enrolled"
],
"offsets": [
[
217,
232
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T16",
"type": "Reference_point",
"text": [
"enrolled"
],
"offsets": [
[
224,
232
]
],
"normalized": []
},
{
"id": "NCT03208998_inc_T17",
"type": "Procedure",
"text": [
"enrolled"
],
"offsets": [
[
224,
232
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03208998_inc_R1",
"type": "Has_temporal",
"arg1_id": "NCT03208998_inc_T4",
"arg2_id": "NCT03208998_inc_T3",
"normalized": []
},
{
"id": "NCT03208998_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03208998_inc_T6",
"arg2_id": "NCT03208998_inc_T7",
"normalized": []
},
{
"id": "NCT03208998_inc_R3",
"type": "Has_temporal",
"arg1_id": "NCT03208998_inc_T7",
"arg2_id": "NCT03208998_inc_T8",
"normalized": []
},
{
"id": "NCT03208998_inc_R4",
"type": "Has_value",
"arg1_id": "NCT03208998_inc_T6",
"arg2_id": "NCT03208998_inc_T10",
"normalized": []
},
{
"id": "NCT03208998_inc_R5",
"type": "Has_temporal",
"arg1_id": "NCT03208998_inc_T10",
"arg2_id": "NCT03208998_inc_T9",
"normalized": []
},
{
"id": "NCT03208998_inc_R6",
"type": "Has_temporal",
"arg1_id": "NCT03208998_inc_T14",
"arg2_id": "NCT03208998_inc_T15",
"normalized": []
},
{
"id": "NCT03208998_inc_R8",
"type": "Has_index",
"arg1_id": "NCT03208998_inc_T15",
"arg2_id": "NCT03208998_inc_T16",
"normalized": []
},
{
"id": "NCT03208998_inc_R9",
"type": "Has_negation",
"arg1_id": "NCT03208998_inc_T14",
"arg2_id": "NCT03208998_inc_T13",
"normalized": []
},
{
"id": "NCT03208998_inc_R10",
"type": "AND",
"arg1_id": "NCT03208998_inc_T11",
"arg2_id": "NCT03208998_inc_T12",
"normalized": []
},
{
"id": "NCT03208998_inc_R11",
"type": "AND",
"arg1_id": "NCT03208998_inc_T5",
"arg2_id": "NCT03208998_inc_T6",
"normalized": []
},
{
"id": "NCT03208998_inc_R12",
"type": "AND",
"arg1_id": "NCT03208998_inc_T12",
"arg2_id": "NCT03208998_inc_T14",
"normalized": []
}
] |
NCT03209011_exc | NCT03209011 | [
{
"id": "NCT03209011_exc_text",
"type": "exclusion",
"text": [
"Active consumption of alcohol and/or drugs\nCo-infection with human immunodeficiency virus, hepatitis C virus, or hepatitis D virus\nHistory of autoimmune hepatitis\nPsychiatric disease\nEvidence of neoplastic diseases of the liver\n"
],
"offsets": [
[
0,
228
]
]
}
] | [
{
"id": "NCT03209011_exc_T1",
"type": "Condition",
"text": [
"consumption of alcohol"
],
"offsets": [
[
7,
29
]
],
"normalized": []
},
{
"id": "NCT03209011_exc_T2",
"type": "Condition",
"text": [
"drugs",
"consumption of"
],
"offsets": [
[
37,
42
],
[
7,
21
]
],
"normalized": []
},
{
"id": "NCT03209011_exc_T3",
"type": "Condition",
"text": [
"human immunodeficiency virus"
],
"offsets": [
[
61,
89
]
],
"normalized": []
},
{
"id": "NCT03209011_exc_T4",
"type": "Condition",
"text": [
"hepatitis C virus"
],
"offsets": [
[
91,
108
]
],
"normalized": []
},
{
"id": "NCT03209011_exc_T5",
"type": "Condition",
"text": [
"hepatitis D virus"
],
"offsets": [
[
113,
130
]
],
"normalized": []
},
{
"id": "NCT03209011_exc_T6",
"type": "Condition",
"text": [
"autoimmune hepatitis"
],
"offsets": [
[
142,
162
]
],
"normalized": []
},
{
"id": "NCT03209011_exc_T7",
"type": "Qualifier",
"text": [
"Active"
],
"offsets": [
[
0,
6
]
],
"normalized": []
},
{
"id": "NCT03209011_exc_T8",
"type": "Scope",
"text": [
"consumption of alcohol and/or drugs"
],
"offsets": [
[
7,
42
]
],
"normalized": []
},
{
"id": "NCT03209011_exc_T9",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
131,
138
]
],
"normalized": []
},
{
"id": "NCT03209011_exc_T10",
"type": "Condition",
"text": [
"Psychiatric disease"
],
"offsets": [
[
163,
182
]
],
"normalized": []
},
{
"id": "NCT03209011_exc_T11",
"type": "Condition",
"text": [
"neoplastic diseases"
],
"offsets": [
[
195,
214
]
],
"normalized": []
},
{
"id": "NCT03209011_exc_T12",
"type": "Mood",
"text": [
"Evidence of"
],
"offsets": [
[
183,
194
]
],
"normalized": []
},
{
"id": "NCT03209011_exc_T13",
"type": "Qualifier",
"text": [
"liver"
],
"offsets": [
[
222,
227
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03209011_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03209011_exc_T8",
"arg2_id": "NCT03209011_exc_T7",
"normalized": []
},
{
"id": "NCT03209011_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT03209011_exc_T6",
"arg2_id": "NCT03209011_exc_T9",
"normalized": []
},
{
"id": "NCT03209011_exc_R3",
"type": "Has_mood",
"arg1_id": "NCT03209011_exc_T11",
"arg2_id": "NCT03209011_exc_T12",
"normalized": []
},
{
"id": "NCT03209011_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT03209011_exc_T11",
"arg2_id": "NCT03209011_exc_T13",
"normalized": []
}
] |
NCT03209011_inc | NCT03209011 | [
{
"id": "NCT03209011_inc_text",
"type": "inclusion",
"text": [
"HBsAg and HBeAg positive for more than 6 months, HBV DNA detectable with ALT level abnormal lasted for three months and at least time190 IU/L or liver puncture biopsy demonstrated apparent inflammation, never treated before enrolled.\n"
],
"offsets": [
[
0,
234
]
]
}
] | [
{
"id": "NCT03209011_inc_T1",
"type": "Condition",
"text": [
"HBeAg positive"
],
"offsets": [
[
10,
24
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T2",
"type": "Condition",
"text": [
"HBsAg",
"positive"
],
"offsets": [
[
0,
5
],
[
16,
24
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T3",
"type": "Temporal",
"text": [
"for more than 6 months"
],
"offsets": [
[
25,
47
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T4",
"type": "Scope",
"text": [
"HBsAg and HBeAg positive"
],
"offsets": [
[
0,
24
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T5",
"type": "Condition",
"text": [
"HBV DNA detectable"
],
"offsets": [
[
49,
67
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T6",
"type": "Measurement",
"text": [
"ALT level"
],
"offsets": [
[
73,
82
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T7",
"type": "Value",
"text": [
"abnormal"
],
"offsets": [
[
83,
91
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T8",
"type": "Temporal",
"text": [
"lasted for three months"
],
"offsets": [
[
92,
115
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T9",
"type": "Temporal",
"text": [
"at least time"
],
"offsets": [
[
120,
133
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T10",
"type": "Value",
"text": [
"190 IU/L"
],
"offsets": [
[
133,
141
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T11",
"type": "Procedure",
"text": [
"liver puncture biopsy"
],
"offsets": [
[
145,
166
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T12",
"type": "Condition",
"text": [
"inflammation"
],
"offsets": [
[
189,
201
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T13",
"type": "Negation",
"text": [
"never"
],
"offsets": [
[
203,
208
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T14",
"type": "Procedure",
"text": [
"treated"
],
"offsets": [
[
209,
216
]
],
"normalized": []
},
{
"id": "NCT03209011_inc_T15",
"type": "Temporal",
"text": [
"before enrolled"
],
"offsets": [
[
217,
232
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03209011_inc_R1",
"type": "Has_temporal",
"arg1_id": "NCT03209011_inc_T4",
"arg2_id": "NCT03209011_inc_T3",
"normalized": []
},
{
"id": "NCT03209011_inc_R2",
"type": "Has_temporal",
"arg1_id": "NCT03209011_inc_T7",
"arg2_id": "NCT03209011_inc_T8",
"normalized": []
},
{
"id": "NCT03209011_inc_R3",
"type": "Has_temporal",
"arg1_id": "NCT03209011_inc_T10",
"arg2_id": "NCT03209011_inc_T9",
"normalized": []
},
{
"id": "NCT03209011_inc_R4",
"type": "Has_value",
"arg1_id": "NCT03209011_inc_T6",
"arg2_id": "NCT03209011_inc_T7",
"normalized": []
},
{
"id": "NCT03209011_inc_R5",
"type": "Has_value",
"arg1_id": "NCT03209011_inc_T6",
"arg2_id": "NCT03209011_inc_T10",
"normalized": []
},
{
"id": "NCT03209011_inc_R6",
"type": "Has_temporal",
"arg1_id": "NCT03209011_inc_T14",
"arg2_id": "NCT03209011_inc_T15",
"normalized": []
},
{
"id": "NCT03209011_inc_R7",
"type": "Has_negation",
"arg1_id": "NCT03209011_inc_T14",
"arg2_id": "NCT03209011_inc_T13",
"normalized": []
},
{
"id": "NCT03209011_inc_R8",
"type": "AND",
"arg1_id": "NCT03209011_inc_T11",
"arg2_id": "NCT03209011_inc_T12",
"normalized": []
},
{
"id": "NCT03209011_inc_R9",
"type": "AND",
"arg1_id": "NCT03209011_inc_T12",
"arg2_id": "NCT03209011_inc_T14",
"normalized": []
},
{
"id": "NCT03209011_inc_R10",
"type": "AND",
"arg1_id": "NCT03209011_inc_T5",
"arg2_id": "NCT03209011_inc_T6",
"normalized": []
}
] |
NCT03209687_exc | NCT03209687 | [
{
"id": "NCT03209687_exc_text",
"type": "exclusion",
"text": [
"Females who have high response (estradiol at time of ovulation trigger is > 5000 pg/ml or more than 15 oocytes are retrieved)\n"
],
"offsets": [
[
0,
126
]
]
}
] | [
{
"id": "NCT03209687_exc_T1",
"type": "Condition",
"text": [
"high response"
],
"offsets": [
[
17,
30
]
],
"normalized": []
},
{
"id": "NCT03209687_exc_T2",
"type": "Person",
"text": [
"Females"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "NCT03209687_exc_T3",
"type": "Measurement",
"text": [
"estradiol"
],
"offsets": [
[
32,
41
]
],
"normalized": []
},
{
"id": "NCT03209687_exc_T4",
"type": "Temporal",
"text": [
"at time of ovulation trigger"
],
"offsets": [
[
42,
70
]
],
"normalized": []
},
{
"id": "NCT03209687_exc_T5",
"type": "Reference_point",
"text": [
"ovulation trigger"
],
"offsets": [
[
53,
70
]
],
"normalized": []
},
{
"id": "NCT03209687_exc_T6",
"type": "Value",
"text": [
"> 5000 pg/ml"
],
"offsets": [
[
74,
86
]
],
"normalized": []
},
{
"id": "NCT03209687_exc_T7",
"type": "Value",
"text": [
"more than 15"
],
"offsets": [
[
90,
102
]
],
"normalized": []
},
{
"id": "NCT03209687_exc_T8",
"type": "Measurement",
"text": [
"oocytes",
"retrieved"
],
"offsets": [
[
103,
110
],
[
115,
124
]
],
"normalized": []
},
{
"id": "NCT03209687_exc_T9",
"type": "Scope",
"text": [
"estradiol at time of ovulation trigger is > 5000 pg/ml or more than 15 oocytes are retrieved"
],
"offsets": [
[
32,
124
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03209687_exc_R1",
"type": "Has_index",
"arg1_id": "NCT03209687_exc_T4",
"arg2_id": "NCT03209687_exc_T5",
"normalized": []
},
{
"id": "NCT03209687_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03209687_exc_T3",
"arg2_id": "NCT03209687_exc_T6",
"normalized": []
},
{
"id": "NCT03209687_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT03209687_exc_T3",
"arg2_id": "NCT03209687_exc_T4",
"normalized": []
},
{
"id": "NCT03209687_exc_R4",
"type": "Has_value",
"arg1_id": "NCT03209687_exc_T8",
"arg2_id": "NCT03209687_exc_T7",
"normalized": []
},
{
"id": "NCT03209687_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT03209687_exc_T1",
"arg2_id": "NCT03209687_exc_T9",
"normalized": []
}
] |
NCT03209687_inc | NCT03209687 | [
{
"id": "NCT03209687_inc_text",
"type": "inclusion",
"text": [
"Females undergoing Intra-Cytoplasmic Sperm Injection (ICSI) cycles\nAge between 20 and 40 years\n"
],
"offsets": [
[
0,
95
]
]
}
] | [
{
"id": "NCT03209687_inc_T1",
"type": "Procedure",
"text": [
"Intra-Cytoplasmic Sperm Injection (ICSI) cycles"
],
"offsets": [
[
19,
66
]
],
"normalized": []
},
{
"id": "NCT03209687_inc_T2",
"type": "Temporal",
"text": [
"undergoing"
],
"offsets": [
[
8,
18
]
],
"normalized": []
},
{
"id": "NCT03209687_inc_T3",
"type": "Person",
"text": [
"Females"
],
"offsets": [
[
0,
7
]
],
"normalized": []
},
{
"id": "NCT03209687_inc_T4",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
67,
70
]
],
"normalized": []
},
{
"id": "NCT03209687_inc_T5",
"type": "Value",
"text": [
"between 20 and 40 years"
],
"offsets": [
[
71,
94
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03209687_inc_R1",
"type": "Has_temporal",
"arg1_id": "NCT03209687_inc_T1",
"arg2_id": "NCT03209687_inc_T2",
"normalized": []
},
{
"id": "NCT03209687_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03209687_inc_T4",
"arg2_id": "NCT03209687_inc_T5",
"normalized": []
}
] |
NCT03211741_exc | NCT03211741 | [
{
"id": "NCT03211741_exc_text",
"type": "exclusion",
"text": [
"Women who are pregnant or breastfeeding (pregnancy defined as the state of a female after conception until the termination of gestation, confirmed by a positive human chorionic gonadotropin laboratory test (> 5mIU/mL)\nWomen of child bearing potential must be practicing effective contraception implemented during the trial and for at least 28 days following the last dose of study medication\nTromboembolic event (CVA or transient ischemic attack, AMI) less than 3 months prior to the intravitreal injection of bevacizumab\nHistory of hypersensitivity for bevacizumab.\n"
],
"offsets": [
[
0,
567
]
]
}
] | [
{
"id": "NCT03211741_exc_T1",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
14,
22
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T2",
"type": "Observation",
"text": [
"breastfeeding"
],
"offsets": [
[
26,
39
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T3",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T4",
"type": "Measurement",
"text": [
"human chorionic gonadotropin"
],
"offsets": [
[
161,
189
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T5",
"type": "Procedure",
"text": [
"human chorionic gonadotropin laboratory test"
],
"offsets": [
[
161,
205
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T6",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
152,
160
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T7",
"type": "Value",
"text": [
"> 5mIU/mL"
],
"offsets": [
[
207,
216
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T9",
"type": "Condition",
"text": [
"Tromboembolic event"
],
"offsets": [
[
392,
411
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T10",
"type": "Condition",
"text": [
"CVA"
],
"offsets": [
[
413,
416
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T11",
"type": "Condition",
"text": [
"transient ischemic attack"
],
"offsets": [
[
420,
445
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T12",
"type": "Condition",
"text": [
"AMI"
],
"offsets": [
[
447,
450
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T13",
"type": "Scope",
"text": [
"CVA or transient ischemic attack, AMI"
],
"offsets": [
[
413,
450
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T14",
"type": "Temporal",
"text": [
"less than 3 months prior to the intravitreal injection of bevacizumab"
],
"offsets": [
[
452,
521
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T15",
"type": "Procedure",
"text": [
"intravitreal injection"
],
"offsets": [
[
484,
506
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T16",
"type": "Drug",
"text": [
"bevacizumab"
],
"offsets": [
[
510,
521
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T17",
"type": "Reference_point",
"text": [
"the intravitreal injection of bevacizumab"
],
"offsets": [
[
480,
521
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T18",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
533,
549
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T19",
"type": "Drug",
"text": [
"bevacizumab"
],
"offsets": [
[
554,
565
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T20",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
522,
529
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T8",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
218,
223
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T21",
"type": "Condition",
"text": [
"child bearing potential"
],
"offsets": [
[
227,
250
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T22",
"type": "Qualifier",
"text": [
"effective"
],
"offsets": [
[
270,
279
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T23",
"type": "Procedure",
"text": [
"contraception"
],
"offsets": [
[
280,
293
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T24",
"type": "Scope",
"text": [
"Women of child bearing potential"
],
"offsets": [
[
218,
250
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T25",
"type": "Temporal",
"text": [
"during the trial"
],
"offsets": [
[
306,
322
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T26",
"type": "Temporal",
"text": [
"for at least 28 days following the last dose of study medication"
],
"offsets": [
[
327,
391
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T27",
"type": "Multiplier",
"text": [
"last dose"
],
"offsets": [
[
362,
371
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T28",
"type": "Drug",
"text": [
"study medication"
],
"offsets": [
[
375,
391
]
],
"normalized": []
},
{
"id": "NCT03211741_exc_T29",
"type": "Reference_point",
"text": [
"the last dose of study medication"
],
"offsets": [
[
358,
391
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03211741_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT03211741_exc_T6",
"arg2_id": "NCT03211741_exc_T7",
"normalized": []
},
{
"id": "NCT03211741_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03211741_exc_T4",
"arg2_id": "NCT03211741_exc_T6",
"normalized": []
},
{
"id": "NCT03211741_exc_R4",
"type": "AND",
"arg1_id": "NCT03211741_exc_T1",
"arg2_id": "NCT03211741_exc_T5",
"normalized": []
},
{
"id": "NCT03211741_exc_R5",
"type": "Subsumes",
"arg1_id": "NCT03211741_exc_T9",
"arg2_id": "NCT03211741_exc_T13",
"normalized": []
},
{
"id": "NCT03211741_exc_R6",
"type": "AND",
"arg1_id": "NCT03211741_exc_T15",
"arg2_id": "NCT03211741_exc_T16",
"normalized": []
},
{
"id": "NCT03211741_exc_R7",
"type": "Has_index",
"arg1_id": "NCT03211741_exc_T14",
"arg2_id": "NCT03211741_exc_T17",
"normalized": []
},
{
"id": "NCT03211741_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT03211741_exc_T9",
"arg2_id": "NCT03211741_exc_T14",
"normalized": []
},
{
"id": "NCT03211741_exc_R10",
"type": "AND",
"arg1_id": "NCT03211741_exc_T18",
"arg2_id": "NCT03211741_exc_T19",
"normalized": []
},
{
"id": "NCT03211741_exc_R11",
"type": "Has_temporal",
"arg1_id": "NCT03211741_exc_T18",
"arg2_id": "NCT03211741_exc_T20",
"normalized": []
},
{
"id": "NCT03211741_exc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT03211741_exc_T23",
"arg2_id": "NCT03211741_exc_T22",
"normalized": []
},
{
"id": "NCT03211741_exc_R13",
"type": "AND",
"arg1_id": "NCT03211741_exc_T24",
"arg2_id": "NCT03211741_exc_T23",
"normalized": []
},
{
"id": "NCT03211741_exc_R14",
"type": "Has_multiplier",
"arg1_id": "NCT03211741_exc_T28",
"arg2_id": "NCT03211741_exc_T27",
"normalized": []
},
{
"id": "NCT03211741_exc_R16",
"type": "Has_index",
"arg1_id": "NCT03211741_exc_T26",
"arg2_id": "NCT03211741_exc_T29",
"normalized": []
},
{
"id": "NCT03211741_exc_R17",
"type": "Has_temporal",
"arg1_id": "NCT03211741_exc_T23",
"arg2_id": "NCT03211741_exc_T25",
"normalized": []
},
{
"id": "NCT03211741_exc_R18",
"type": "Has_temporal",
"arg1_id": "NCT03211741_exc_T23",
"arg2_id": "NCT03211741_exc_T26",
"normalized": []
}
] |
NCT03211741_inc | NCT03211741 | [
{
"id": "NCT03211741_inc_text",
"type": "inclusion",
"text": [
"Age = 18 years of either gender\nWritten informed consent must be obtained before any intravitreal injection of bevacizumab is performed\nVisual impairment predominantly due to abnormal new vessel ingrowth and/or macular edema. The presence of fluid (intraretinal, subretinal or sub-RPE) detected clinically or on the ocular coherence tomography.\n"
],
"offsets": [
[
0,
345
]
]
}
] | [
{
"id": "NCT03211741_inc_T1",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT03211741_inc_T2",
"type": "Value",
"text": [
"= 18 years"
],
"offsets": [
[
4,
14
]
],
"normalized": []
},
{
"id": "NCT03211741_inc_T3",
"type": "Person",
"text": [
"either gender"
],
"offsets": [
[
18,
31
]
],
"normalized": []
},
{
"id": "NCT03211741_inc_T5",
"type": "Condition",
"text": [
"Visual impairment"
],
"offsets": [
[
136,
153
]
],
"normalized": []
},
{
"id": "NCT03211741_inc_T6",
"type": "Condition",
"text": [
"abnormal new vessel ingrowth"
],
"offsets": [
[
175,
203
]
],
"normalized": []
},
{
"id": "NCT03211741_inc_T7",
"type": "Condition",
"text": [
"macular edema"
],
"offsets": [
[
211,
224
]
],
"normalized": []
},
{
"id": "NCT03211741_inc_T8",
"type": "Qualifier",
"text": [
"intraretinal"
],
"offsets": [
[
249,
261
]
],
"normalized": []
},
{
"id": "NCT03211741_inc_T9",
"type": "Qualifier",
"text": [
"subretinal"
],
"offsets": [
[
263,
273
]
],
"normalized": []
},
{
"id": "NCT03211741_inc_T10",
"type": "Qualifier",
"text": [
"sub-RPE"
],
"offsets": [
[
277,
284
]
],
"normalized": []
},
{
"id": "NCT03211741_inc_T11",
"type": "Procedure",
"text": [
"ocular coherence tomography"
],
"offsets": [
[
316,
343
]
],
"normalized": []
},
{
"id": "NCT03211741_inc_T12",
"type": "Condition",
"text": [
"fluid"
],
"offsets": [
[
242,
247
]
],
"normalized": []
},
{
"id": "NCT03211741_inc_T13",
"type": "Scope",
"text": [
"intraretinal, subretinal or sub-RPE"
],
"offsets": [
[
249,
284
]
],
"normalized": []
},
{
"id": "NCT03211741_inc_T14",
"type": "Scope",
"text": [
"abnormal new vessel ingrowth and/or macular edema"
],
"offsets": [
[
175,
224
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03211741_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03211741_inc_T1",
"arg2_id": "NCT03211741_inc_T2",
"normalized": []
},
{
"id": "NCT03211741_inc_R2",
"type": "Subsumes",
"arg1_id": "NCT03211741_inc_T12",
"arg2_id": "NCT03211741_inc_T13",
"normalized": []
},
{
"id": "NCT03211741_inc_R3",
"type": "AND",
"arg1_id": "NCT03211741_inc_T11",
"arg2_id": "NCT03211741_inc_T12",
"normalized": []
},
{
"id": "NCT03211741_inc_R4",
"type": "Has_scope",
"arg1_id": "NCT03211741_inc_T5",
"arg2_id": "NCT03211741_inc_T14",
"normalized": []
}
] |
NCT03212352_exc | NCT03212352 | [
{
"id": "NCT03212352_exc_text",
"type": "exclusion",
"text": [
"Patient does not meet inclusion criteria, discovered after randomization\nInability to give informed consent\nKnown clotting disorder or use of anticoagulants\nKnown risk factors for, or presence of, a cardiovascular disease\nLanguage barrier\n"
],
"offsets": [
[
0,
239
]
]
}
] | [
{
"id": "NCT03212352_exc_T3",
"type": "Condition",
"text": [
"clotting disorder"
],
"offsets": [
[
114,
131
]
],
"normalized": []
},
{
"id": "NCT03212352_exc_T4",
"type": "Drug",
"text": [
"anticoagulants"
],
"offsets": [
[
142,
156
]
],
"normalized": []
},
{
"id": "NCT03212352_exc_T5",
"type": "Condition",
"text": [
"cardiovascular disease"
],
"offsets": [
[
199,
221
]
],
"normalized": []
},
{
"id": "NCT03212352_exc_T6",
"type": "Observation",
"text": [
"k factors fo",
"diovascular disease\nLa"
],
"offsets": [
[
166,
178
],
[
202,
224
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03212352_exc_R1",
"type": "AND",
"arg1_id": "NCT03212352_exc_T3",
"arg2_id": "NCT03212352_exc_T4",
"normalized": []
}
] |
NCT03212352_inc | NCT03212352 | [
{
"id": "NCT03212352_inc_text",
"type": "inclusion",
"text": [
"a crown-rump length = 6mm and no cardiac activity OR\na crown-rump length <6mm and no fetal growth at least one week later OR\nAt least one week after diagnosis OR a discrepancy of at least one week between crown-rump length and calendar gestational age\nIntra-uterine pregnancy\nWomen aged above 16 years\nHemodynamic stable patient\nNo signs of infection\nNo signs of incomplete abortion\nNo contraindications for mifepristone or misoprostol\n"
],
"offsets": [
[
0,
436
]
]
}
] | [
{
"id": "NCT03212352_inc_T1",
"type": "Measurement",
"text": [
"crown-rump length"
],
"offsets": [
[
2,
19
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T2",
"type": "Value",
"text": [
"= 6mm"
],
"offsets": [
[
20,
25
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T3",
"type": "Negation",
"text": [
"no"
],
"offsets": [
[
30,
32
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T4",
"type": "Observation",
"text": [
"cardiac activity"
],
"offsets": [
[
33,
49
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T5",
"type": "Measurement",
"text": [
"crown-rump length"
],
"offsets": [
[
55,
72
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T6",
"type": "Value",
"text": [
"<6mm"
],
"offsets": [
[
73,
77
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T7",
"type": "Negation",
"text": [
"no"
],
"offsets": [
[
82,
84
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T8",
"type": "Observation",
"text": [
"fetal growth"
],
"offsets": [
[
85,
97
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T9",
"type": "Temporal",
"text": [
"at least one week later"
],
"offsets": [
[
98,
121
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T10",
"type": "Scope",
"text": [
"crown-rump length <6mm and no fetal growth"
],
"offsets": [
[
55,
97
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T11",
"type": "Temporal",
"text": [
"At least one week after diagnosis"
],
"offsets": [
[
125,
158
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T12",
"type": "Reference_point",
"text": [
"diagnosis"
],
"offsets": [
[
149,
158
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T13",
"type": "Condition",
"text": [
"discrepancy"
],
"offsets": [
[
164,
175
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T14",
"type": "Temporal",
"text": [
"at least one week between crown-rump length and calendar gestational age"
],
"offsets": [
[
179,
251
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T15",
"type": "Reference_point",
"text": [
"crown-rump length"
],
"offsets": [
[
205,
222
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T16",
"type": "Reference_point",
"text": [
"calendar gestational age"
],
"offsets": [
[
227,
251
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T17",
"type": "Scope",
"text": [
"t least one week later OR\nA",
" least one week after diagnosis "
],
"offsets": [
[
99,
126
],
[
127,
159
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T18",
"type": "Condition",
"text": [
"Intra-uterine pregnancy"
],
"offsets": [
[
252,
275
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T19",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
276,
281
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T20",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
282,
286
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T21",
"type": "Value",
"text": [
"above 16 years"
],
"offsets": [
[
287,
301
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T22",
"type": "Condition",
"text": [
"Hemodynamic stable"
],
"offsets": [
[
302,
320
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T23",
"type": "Negation",
"text": [
"No"
],
"offsets": [
[
329,
331
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T24",
"type": "Negation",
"text": [
"No"
],
"offsets": [
[
351,
353
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T25",
"type": "Negation",
"text": [
"No"
],
"offsets": [
[
383,
385
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T26",
"type": "Condition",
"text": [
"signs of infection"
],
"offsets": [
[
332,
350
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T27",
"type": "Condition",
"text": [
"signs of incomplete abortion"
],
"offsets": [
[
354,
382
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T28",
"type": "Drug",
"text": [
"mifepristone"
],
"offsets": [
[
408,
420
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T29",
"type": "Drug",
"text": [
"misoprostol"
],
"offsets": [
[
424,
435
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T30",
"type": "Mood",
"text": [
"contraindications for"
],
"offsets": [
[
386,
407
]
],
"normalized": []
},
{
"id": "NCT03212352_inc_T31",
"type": "Scope",
"text": [
"mifepristone or misoprostol"
],
"offsets": [
[
408,
435
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03212352_inc_R1",
"type": "Has_negation",
"arg1_id": "NCT03212352_inc_T4",
"arg2_id": "NCT03212352_inc_T3",
"normalized": []
},
{
"id": "NCT03212352_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03212352_inc_T1",
"arg2_id": "NCT03212352_inc_T2",
"normalized": []
},
{
"id": "NCT03212352_inc_R3",
"type": "Has_negation",
"arg1_id": "NCT03212352_inc_T8",
"arg2_id": "NCT03212352_inc_T7",
"normalized": []
},
{
"id": "NCT03212352_inc_R4",
"type": "Has_value",
"arg1_id": "NCT03212352_inc_T5",
"arg2_id": "NCT03212352_inc_T6",
"normalized": []
},
{
"id": "NCT03212352_inc_R5",
"type": "Has_index",
"arg1_id": "NCT03212352_inc_T11",
"arg2_id": "NCT03212352_inc_T12",
"normalized": []
},
{
"id": "NCT03212352_inc_R6",
"type": "Has_temporal",
"arg1_id": "NCT03212352_inc_T13",
"arg2_id": "NCT03212352_inc_T14",
"normalized": []
},
{
"id": "NCT03212352_inc_R7",
"type": "Has_index",
"arg1_id": "NCT03212352_inc_T14",
"arg2_id": "NCT03212352_inc_T15",
"normalized": []
},
{
"id": "NCT03212352_inc_R8",
"type": "Has_index",
"arg1_id": "NCT03212352_inc_T14",
"arg2_id": "NCT03212352_inc_T16",
"normalized": []
},
{
"id": "NCT03212352_inc_R9",
"type": "Has_temporal",
"arg1_id": "NCT03212352_inc_T10",
"arg2_id": "NCT03212352_inc_T9",
"normalized": []
},
{
"id": "NCT03212352_inc_R10",
"type": "Has_temporal",
"arg1_id": "NCT03212352_inc_T10",
"arg2_id": "NCT03212352_inc_T11",
"normalized": []
},
{
"id": "NCT03212352_inc_R11",
"type": "Has_value",
"arg1_id": "NCT03212352_inc_T20",
"arg2_id": "NCT03212352_inc_T21",
"normalized": []
},
{
"id": "NCT03212352_inc_R12",
"type": "Has_negation",
"arg1_id": "NCT03212352_inc_T26",
"arg2_id": "NCT03212352_inc_T23",
"normalized": []
},
{
"id": "NCT03212352_inc_R13",
"type": "Has_negation",
"arg1_id": "NCT03212352_inc_T27",
"arg2_id": "NCT03212352_inc_T24",
"normalized": []
},
{
"id": "NCT03212352_inc_R14",
"type": "Has_mood",
"arg1_id": "NCT03212352_inc_T31",
"arg2_id": "NCT03212352_inc_T30",
"normalized": []
},
{
"id": "NCT03212352_inc_R15",
"type": "Has_negation",
"arg1_id": "NCT03212352_inc_T30",
"arg2_id": "NCT03212352_inc_T25",
"normalized": []
}
] |
NCT03213834_exc | NCT03213834 | [
{
"id": "NCT03213834_exc_text",
"type": "exclusion",
"text": [
"age <18 years;\nPregnancy\ninability to give informed written consent;\nprevious thoracic surgery or thrombolytic therapy for pleural infection;\nmedical thoracoscopy cannot be performed within 48 hours;\ninability to tolerate procedure due to hemodynamic instability or severe hypoxemia;\ninability to correct coagulopathy;\npresence of a homogeneously echogenic effusion on pleural US27 -\n"
],
"offsets": [
[
0,
384
]
]
}
] | [
{
"id": "NCT03213834_exc_T1",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T2",
"type": "Value",
"text": [
"<18 years"
],
"offsets": [
[
4,
13
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T3",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
15,
24
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T5",
"type": "Procedure",
"text": [
"thoracic surgery"
],
"offsets": [
[
78,
94
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T6",
"type": "Procedure",
"text": [
"thrombolytic therapy"
],
"offsets": [
[
98,
118
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T7",
"type": "Condition",
"text": [
"pleural infection"
],
"offsets": [
[
123,
140
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T8",
"type": "Scope",
"text": [
"thoracic surgery or thrombolytic therapy"
],
"offsets": [
[
78,
118
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T9",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
69,
77
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T10",
"type": "Procedure",
"text": [
"medical thoracoscopy"
],
"offsets": [
[
142,
162
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T11",
"type": "Mood",
"text": [
"cannot be performed"
],
"offsets": [
[
163,
182
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T12",
"type": "Temporal",
"text": [
"within 48 hours"
],
"offsets": [
[
183,
198
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T13",
"type": "Negation",
"text": [
"cannot"
],
"offsets": [
[
163,
169
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T14",
"type": "Condition",
"text": [
"inability to tolerate"
],
"offsets": [
[
200,
221
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T15",
"type": "Procedure",
"text": [
"procedure"
],
"offsets": [
[
222,
231
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T16",
"type": "Condition",
"text": [
"hemodynamic instability"
],
"offsets": [
[
239,
262
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T17",
"type": "Condition",
"text": [
"hypoxemia"
],
"offsets": [
[
273,
282
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T18",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
266,
272
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T19",
"type": "Scope",
"text": [
"hemodynamic instability or severe hypoxemia"
],
"offsets": [
[
239,
282
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T20",
"type": "Scope",
"text": [
"inability to tolerate procedure"
],
"offsets": [
[
200,
231
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T21",
"type": "Condition",
"text": [
"coagulopathy"
],
"offsets": [
[
305,
317
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T22",
"type": "Procedure",
"text": [
"correct"
],
"offsets": [
[
297,
304
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T23",
"type": "Mood",
"text": [
"inability to"
],
"offsets": [
[
284,
296
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T24",
"type": "Condition",
"text": [
"homogeneously echogenic effusion"
],
"offsets": [
[
333,
365
]
],
"normalized": []
},
{
"id": "NCT03213834_exc_T25",
"type": "Procedure",
"text": [
"pleural US"
],
"offsets": [
[
369,
379
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03213834_exc_R1",
"type": "Has_value",
"arg1_id": "NCT03213834_exc_T1",
"arg2_id": "NCT03213834_exc_T2",
"normalized": []
},
{
"id": "NCT03213834_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT03213834_exc_T8",
"arg2_id": "NCT03213834_exc_T9",
"normalized": []
},
{
"id": "NCT03213834_exc_R3",
"type": "AND",
"arg1_id": "NCT03213834_exc_T8",
"arg2_id": "NCT03213834_exc_T7",
"normalized": []
},
{
"id": "NCT03213834_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT03213834_exc_T10",
"arg2_id": "NCT03213834_exc_T12",
"normalized": []
},
{
"id": "NCT03213834_exc_R5",
"type": "Has_mood",
"arg1_id": "NCT03213834_exc_T10",
"arg2_id": "NCT03213834_exc_T11",
"normalized": []
},
{
"id": "NCT03213834_exc_R7",
"type": "AND",
"arg1_id": "NCT03213834_exc_T14",
"arg2_id": "NCT03213834_exc_T15",
"normalized": []
},
{
"id": "NCT03213834_exc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT03213834_exc_T17",
"arg2_id": "NCT03213834_exc_T18",
"normalized": []
},
{
"id": "NCT03213834_exc_R9",
"type": "Has_scope",
"arg1_id": "NCT03213834_exc_T20",
"arg2_id": "NCT03213834_exc_T19",
"normalized": []
},
{
"id": "NCT03213834_exc_R10",
"type": "AND",
"arg1_id": "NCT03213834_exc_T22",
"arg2_id": "NCT03213834_exc_T21",
"normalized": []
},
{
"id": "NCT03213834_exc_R11",
"type": "Has_mood",
"arg1_id": "NCT03213834_exc_T22",
"arg2_id": "NCT03213834_exc_T23",
"normalized": []
},
{
"id": "NCT03213834_exc_R12",
"type": "AND",
"arg1_id": "NCT03213834_exc_T24",
"arg2_id": "NCT03213834_exc_T25",
"normalized": []
}
] |
NCT03213834_inc | NCT03213834 | [
{
"id": "NCT03213834_inc_text",
"type": "inclusion",
"text": [
"CPPE along with evidence of septated pleural effusion on pleural ultrasonography and/or chest CT scan\nempyema.\n"
],
"offsets": [
[
0,
111
]
]
}
] | [
{
"id": "NCT03213834_inc_T1",
"type": "Condition",
"text": [
"septated pleural effusion"
],
"offsets": [
[
28,
53
]
],
"normalized": []
},
{
"id": "NCT03213834_inc_T2",
"type": "Procedure",
"text": [
"pleural ultrasonography"
],
"offsets": [
[
57,
80
]
],
"normalized": []
},
{
"id": "NCT03213834_inc_T3",
"type": "Procedure",
"text": [
"chest CT scan"
],
"offsets": [
[
88,
101
]
],
"normalized": []
},
{
"id": "NCT03213834_inc_T4",
"type": "Condition",
"text": [
"CPPE"
],
"offsets": [
[
0,
4
]
],
"normalized": []
},
{
"id": "NCT03213834_inc_T5",
"type": "Scope",
"text": [
"CPPE along with evidence of septated pleural effusion"
],
"offsets": [
[
0,
53
]
],
"normalized": []
},
{
"id": "NCT03213834_inc_T6",
"type": "Mood",
"text": [
"evidence of"
],
"offsets": [
[
16,
27
]
],
"normalized": []
},
{
"id": "NCT03213834_inc_T7",
"type": "Scope",
"text": [
"pleural ultrasonography and/or chest CT scan"
],
"offsets": [
[
57,
101
]
],
"normalized": []
},
{
"id": "NCT03213834_inc_T8",
"type": "Condition",
"text": [
"empyema"
],
"offsets": [
[
102,
109
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03213834_inc_R1",
"type": "Has_mood",
"arg1_id": "NCT03213834_inc_T1",
"arg2_id": "NCT03213834_inc_T6",
"normalized": []
},
{
"id": "NCT03213834_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT03213834_inc_T5",
"arg2_id": "NCT03213834_inc_T7",
"normalized": []
}
] |
NCT03216447_exc | NCT03216447 | [
{
"id": "NCT03216447_exc_text",
"type": "exclusion",
"text": [
"Patient has previously received or is receiving an organ transplant other than a liver.\nPatient currently requires dialysis\nRecipient or donor is known to be seropositive for human immunodeficiency virus (HIV)\nPatient has received a liver transplant from a non-heart beating donor\nPatient who is HCV negative has received an HCV positive (HCV RNA by PCR or HCV antibody) donor liver\nPatient who is HbsAg negative has received an HbsAg positive (HBV DNA by PCR or HBV antibody) donor liver\nPatient has received a liver transplant from a decrease donor > 70 years of age\nPatient has a current malignancy or a history of malignancy (within the past 5 years), except hepatocellular carcinoma within UCSF Criteria and basal or non-metastatic squamous cell carcinoma of skin that has been treated successfully.\nPatient is hemodynamically unstable on POD 15\n"
],
"offsets": [
[
0,
851
]
]
}
] | [
{
"id": "NCT03216447_exc_T1",
"type": "Procedure",
"text": [
"organ transplant"
],
"offsets": [
[
51,
67
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T2",
"type": "Negation",
"text": [
"other than"
],
"offsets": [
[
68,
78
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T3",
"type": "Qualifier",
"text": [
"liver"
],
"offsets": [
[
81,
86
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T4",
"type": "Procedure",
"text": [
"dialysis"
],
"offsets": [
[
115,
123
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T5",
"type": "Measurement",
"text": [
"human immunodeficiency virus"
],
"offsets": [
[
175,
203
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T6",
"type": "Value",
"text": [
"seropositive"
],
"offsets": [
[
158,
170
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T7",
"type": "Measurement",
"text": [
"HIV"
],
"offsets": [
[
205,
208
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T8",
"type": "Person",
"text": [
"Recipient"
],
"offsets": [
[
124,
133
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T9",
"type": "Person",
"text": [
"donor"
],
"offsets": [
[
137,
142
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T10",
"type": "Scope",
"text": [
"Recipient or donor"
],
"offsets": [
[
124,
142
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T11",
"type": "Procedure",
"text": [
"liver transplant"
],
"offsets": [
[
233,
249
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T12",
"type": "Person",
"text": [
"donor"
],
"offsets": [
[
275,
280
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T13",
"type": "Qualifier",
"text": [
"heart beating"
],
"offsets": [
[
261,
274
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T14",
"type": "Negation",
"text": [
"non"
],
"offsets": [
[
257,
260
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T15",
"type": "Measurement",
"text": [
"HCV"
],
"offsets": [
[
296,
299
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T16",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
300,
308
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T17",
"type": "Qualifier",
"text": [
"liver"
],
"offsets": [
[
377,
382
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T18",
"type": "Measurement",
"text": [
"HCV"
],
"offsets": [
[
325,
328
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T19",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
329,
337
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T20",
"type": "Person",
"text": [
"donor"
],
"offsets": [
[
371,
376
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T21",
"type": "Measurement",
"text": [
"HCV RNA"
],
"offsets": [
[
339,
346
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T22",
"type": "Measurement",
"text": [
"HCV antibody"
],
"offsets": [
[
357,
369
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T23",
"type": "Measurement",
"text": [
"PCR"
],
"offsets": [
[
350,
353
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T24",
"type": "Scope",
"text": [
"HCV RNA by PCR or HCV antibody"
],
"offsets": [
[
339,
369
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T25",
"type": "Measurement",
"text": [
"HbsAg"
],
"offsets": [
[
398,
403
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T26",
"type": "Value",
"text": [
"negative"
],
"offsets": [
[
404,
412
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T27",
"type": "Measurement",
"text": [
"HbsAg"
],
"offsets": [
[
429,
434
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T28",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
435,
443
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T29",
"type": "Measurement",
"text": [
"PCR"
],
"offsets": [
[
456,
459
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T30",
"type": "Measurement",
"text": [
"HBV DNA"
],
"offsets": [
[
445,
452
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T31",
"type": "Measurement",
"text": [
"HBV antibody"
],
"offsets": [
[
463,
475
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T32",
"type": "Scope",
"text": [
"HBV DNA by PCR or HBV antibody"
],
"offsets": [
[
445,
475
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T33",
"type": "Person",
"text": [
"donor"
],
"offsets": [
[
477,
482
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T34",
"type": "Qualifier",
"text": [
"liver"
],
"offsets": [
[
483,
488
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T35",
"type": "Procedure",
"text": [
"liver transplant"
],
"offsets": [
[
512,
528
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T36",
"type": "Person",
"text": [
"donor"
],
"offsets": [
[
545,
550
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T37",
"type": "Value",
"text": [
"> 70 years"
],
"offsets": [
[
551,
561
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T38",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
565,
568
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T39",
"type": "Condition",
"text": [
"malignancy"
],
"offsets": [
[
591,
601
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T40",
"type": "Condition",
"text": [
"history of malignancy"
],
"offsets": [
[
607,
628
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T41",
"type": "Temporal",
"text": [
"within the past 5 years"
],
"offsets": [
[
630,
653
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T42",
"type": "Condition",
"text": [
"hepatocellular carcinoma"
],
"offsets": [
[
663,
687
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T43",
"type": "Negation",
"text": [
"except"
],
"offsets": [
[
656,
662
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T44",
"type": "Measurement",
"text": [
"UCSF Criteria"
],
"offsets": [
[
695,
708
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T45",
"type": "Condition",
"text": [
"r non",
"rcinoma of skin that h"
],
"offsets": [
[
720,
725
],
[
753,
775
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T46",
"type": "Condition",
"text": [
"squamous cell carcinoma of skin"
],
"offsets": [
[
737,
768
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T47",
"type": "Qualifier",
"text": [
"non-metastatic"
],
"offsets": [
[
722,
736
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T48",
"type": "Mood",
"text": [
"treated successfully"
],
"offsets": [
[
783,
803
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T49",
"type": "Scope",
"text": [
"hepatocellular carcinoma within UCSF Criteria and basal or non-metastatic squamous cell carcinoma of skin"
],
"offsets": [
[
663,
768
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T50",
"type": "Condition",
"text": [
"hemodynamically unstable"
],
"offsets": [
[
816,
840
]
],
"normalized": []
},
{
"id": "NCT03216447_exc_T51",
"type": "Measurement",
"text": [
"POD 15"
],
"offsets": [
[
844,
850
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03216447_exc_R1",
"type": "Has_negation",
"arg1_id": "NCT03216447_exc_T3",
"arg2_id": "NCT03216447_exc_T2",
"normalized": []
},
{
"id": "NCT03216447_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03216447_exc_T1",
"arg2_id": "NCT03216447_exc_T3",
"normalized": []
},
{
"id": "NCT03216447_exc_R3",
"type": "Has_value",
"arg1_id": "NCT03216447_exc_T5",
"arg2_id": "NCT03216447_exc_T6",
"normalized": []
},
{
"id": "NCT03216447_exc_R4",
"type": "Subsumes",
"arg1_id": "NCT03216447_exc_T5",
"arg2_id": "NCT03216447_exc_T7",
"normalized": []
},
{
"id": "NCT03216447_exc_R5",
"type": "AND",
"arg1_id": "NCT03216447_exc_T10",
"arg2_id": "NCT03216447_exc_T5",
"normalized": []
},
{
"id": "NCT03216447_exc_R6",
"type": "Has_negation",
"arg1_id": "NCT03216447_exc_T13",
"arg2_id": "NCT03216447_exc_T14",
"normalized": []
},
{
"id": "NCT03216447_exc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT03216447_exc_T12",
"arg2_id": "NCT03216447_exc_T13",
"normalized": []
},
{
"id": "NCT03216447_exc_R8",
"type": "Has_value",
"arg1_id": "NCT03216447_exc_T15",
"arg2_id": "NCT03216447_exc_T16",
"normalized": []
},
{
"id": "NCT03216447_exc_R9",
"type": "Has_value",
"arg1_id": "NCT03216447_exc_T18",
"arg2_id": "NCT03216447_exc_T19",
"normalized": []
},
{
"id": "NCT03216447_exc_R10",
"type": "AND",
"arg1_id": "NCT03216447_exc_T20",
"arg2_id": "NCT03216447_exc_T18",
"normalized": []
},
{
"id": "NCT03216447_exc_R11",
"type": "AND",
"arg1_id": "NCT03216447_exc_T21",
"arg2_id": "NCT03216447_exc_T23",
"normalized": []
},
{
"id": "NCT03216447_exc_R12",
"type": "Subsumes",
"arg1_id": "NCT03216447_exc_T18",
"arg2_id": "NCT03216447_exc_T24",
"normalized": []
},
{
"id": "NCT03216447_exc_R13",
"type": "Has_qualifier",
"arg1_id": "NCT03216447_exc_T20",
"arg2_id": "NCT03216447_exc_T17",
"normalized": []
},
{
"id": "NCT03216447_exc_R14",
"type": "Has_value",
"arg1_id": "NCT03216447_exc_T25",
"arg2_id": "NCT03216447_exc_T26",
"normalized": []
},
{
"id": "NCT03216447_exc_R15",
"type": "AND",
"arg1_id": "NCT03216447_exc_T29",
"arg2_id": "NCT03216447_exc_T30",
"normalized": []
},
{
"id": "NCT03216447_exc_R16",
"type": "Has_qualifier",
"arg1_id": "NCT03216447_exc_T33",
"arg2_id": "NCT03216447_exc_T34",
"normalized": []
},
{
"id": "NCT03216447_exc_R17",
"type": "Has_value",
"arg1_id": "NCT03216447_exc_T27",
"arg2_id": "NCT03216447_exc_T28",
"normalized": []
},
{
"id": "NCT03216447_exc_R18",
"type": "Subsumes",
"arg1_id": "NCT03216447_exc_T27",
"arg2_id": "NCT03216447_exc_T32",
"normalized": []
},
{
"id": "NCT03216447_exc_R19",
"type": "Has_value",
"arg1_id": "NCT03216447_exc_T38",
"arg2_id": "NCT03216447_exc_T37",
"normalized": []
},
{
"id": "NCT03216447_exc_R20",
"type": "Has_temporal",
"arg1_id": "NCT03216447_exc_T40",
"arg2_id": "NCT03216447_exc_T41",
"normalized": []
},
{
"id": "NCT03216447_exc_R22",
"type": "Has_qualifier",
"arg1_id": "NCT03216447_exc_T46",
"arg2_id": "NCT03216447_exc_T47",
"normalized": []
},
{
"id": "NCT03216447_exc_R23",
"type": "AND",
"arg1_id": "NCT03216447_exc_T44",
"arg2_id": "NCT03216447_exc_T42",
"normalized": []
},
{
"id": "NCT03216447_exc_R21",
"type": "Has_mood",
"arg1_id": "NCT03216447_exc_T49",
"arg2_id": "NCT03216447_exc_T48",
"normalized": []
},
{
"id": "NCT03216447_exc_R24",
"type": "Has_negation",
"arg1_id": "NCT03216447_exc_T49",
"arg2_id": "NCT03216447_exc_T43",
"normalized": []
},
{
"id": "NCT03216447_exc_R25",
"type": "AND",
"arg1_id": "NCT03216447_exc_T51",
"arg2_id": "NCT03216447_exc_T50",
"normalized": []
}
] |
NCT03216447_inc | NCT03216447 | [
{
"id": "NCT03216447_inc_text",
"type": "inclusion",
"text": [
"Patient has been fully informed and has signed an IRB approved informed consent form within 7 days (Day 7-13) prior to POD 15 and is willing and able to follow study procedure\nPatient is a primary liver transplant recipient\nPatient is 20 to 70 years of age\nPatient should be clearly conscious, fully understand and able to answer questionnaire\n"
],
"offsets": [
[
0,
344
]
]
}
] | [
{
"id": "NCT03216447_inc_T2",
"type": "Condition",
"text": [
"primary liver transplant"
],
"offsets": [
[
189,
213
]
],
"normalized": []
},
{
"id": "NCT03216447_inc_T3",
"type": "Person",
"text": [
"recipient"
],
"offsets": [
[
214,
223
]
],
"normalized": []
},
{
"id": "NCT03216447_inc_T4",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
253,
256
]
],
"normalized": []
},
{
"id": "NCT03216447_inc_T5",
"type": "Value",
"text": [
"20 to 70 years"
],
"offsets": [
[
235,
249
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03216447_inc_R1",
"type": "AND",
"arg1_id": "NCT03216447_inc_T3",
"arg2_id": "NCT03216447_inc_T2",
"normalized": []
},
{
"id": "NCT03216447_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03216447_inc_T4",
"arg2_id": "NCT03216447_inc_T5",
"normalized": []
}
] |
NCT03216967_exc | NCT03216967 | [
{
"id": "NCT03216967_exc_text",
"type": "exclusion",
"text": [
"Known proved BKV nephropathy\nHypersensitivity to everolimus, sirolimus or excipient\nConcomitant treatment by leflunomide, cidofovir, sirolimus, Millepertuis (Hypericum Perforatum)\nPregnant or lactating women\nWomen of child bearing potential unless they are using a birth control method\n"
],
"offsets": [
[
0,
286
]
]
}
] | [
{
"id": "NCT03216967_exc_T1",
"type": "Qualifier",
"text": [
"proved"
],
"offsets": [
[
6,
12
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T2",
"type": "Condition",
"text": [
"BKV nephropathy"
],
"offsets": [
[
13,
28
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T3",
"type": "Condition",
"text": [
"Hypersensitivity"
],
"offsets": [
[
29,
45
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T4",
"type": "Drug",
"text": [
"everolimus"
],
"offsets": [
[
49,
59
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T5",
"type": "Drug",
"text": [
"sirolimus"
],
"offsets": [
[
61,
70
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T6",
"type": "Drug",
"text": [
"excipient"
],
"offsets": [
[
74,
83
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T7",
"type": "Scope",
"text": [
"everolimus, sirolimus or excipient"
],
"offsets": [
[
49,
83
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T8",
"type": "Temporal",
"text": [
"Concomitant"
],
"offsets": [
[
84,
95
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T10",
"type": "Drug",
"text": [
"leflunomide"
],
"offsets": [
[
109,
120
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T11",
"type": "Drug",
"text": [
"cidofovir"
],
"offsets": [
[
122,
131
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T12",
"type": "Drug",
"text": [
"sirolimus"
],
"offsets": [
[
133,
142
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T13",
"type": "Drug",
"text": [
"Millepertuis"
],
"offsets": [
[
144,
156
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T9",
"type": "Drug",
"text": [
"Hypericum Perforatum"
],
"offsets": [
[
158,
178
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T14",
"type": "Scope",
"text": [
"leflunomide, cidofovir, sirolimus, Millepertuis (Hypericum Perforatum)"
],
"offsets": [
[
109,
179
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T15",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
180,
188
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T16",
"type": "Condition",
"text": [
"lactating"
],
"offsets": [
[
192,
201
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T17",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
202,
207
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T18",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
208,
213
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T19",
"type": "Condition",
"text": [
"child bearing potential"
],
"offsets": [
[
217,
240
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T20",
"type": "Negation",
"text": [
"unless"
],
"offsets": [
[
241,
247
]
],
"normalized": []
},
{
"id": "NCT03216967_exc_T21",
"type": "Procedure",
"text": [
"birth control method"
],
"offsets": [
[
265,
285
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03216967_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03216967_exc_T2",
"arg2_id": "NCT03216967_exc_T1",
"normalized": []
},
{
"id": "NCT03216967_exc_R2",
"type": "Has_scope",
"arg1_id": "NCT03216967_exc_T3",
"arg2_id": "NCT03216967_exc_T7",
"normalized": []
},
{
"id": "NCT03216967_exc_R3",
"type": "Subsumes",
"arg1_id": "NCT03216967_exc_T13",
"arg2_id": "NCT03216967_exc_T9",
"normalized": []
},
{
"id": "NCT03216967_exc_R4",
"type": "Has_temporal",
"arg1_id": "NCT03216967_exc_T14",
"arg2_id": "NCT03216967_exc_T8",
"normalized": []
},
{
"id": "NCT03216967_exc_R5",
"type": "Has_negation",
"arg1_id": "NCT03216967_exc_T21",
"arg2_id": "NCT03216967_exc_T20",
"normalized": []
}
] |
NCT03216967_inc | NCT03216967 | [
{
"id": "NCT03216967_inc_text",
"type": "inclusion",
"text": [
"Adult patients\nKidney transplant recipients\nPatients treated by a calcineurin inhibitor and mycophenolic acid\nViremia >= 3 log UI/ml\nPatients who have given written informed consent\nNegative pregnancy test (blood ß-HCG dosage)\n"
],
"offsets": [
[
0,
227
]
]
}
] | [
{
"id": "NCT03216967_inc_T1",
"type": "Person",
"text": [
"Adult"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT03216967_inc_T2",
"type": "Procedure",
"text": [
"Kidney transplant"
],
"offsets": [
[
15,
32
]
],
"normalized": []
},
{
"id": "NCT03216967_inc_T3",
"type": "Drug",
"text": [
"calcineurin inhibitor"
],
"offsets": [
[
66,
87
]
],
"normalized": []
},
{
"id": "NCT03216967_inc_T4",
"type": "Drug",
"text": [
"mycophenolic acid"
],
"offsets": [
[
92,
109
]
],
"normalized": []
},
{
"id": "NCT03216967_inc_T5",
"type": "Measurement",
"text": [
"Viremia"
],
"offsets": [
[
110,
117
]
],
"normalized": []
},
{
"id": "NCT03216967_inc_T6",
"type": "Value",
"text": [
">= 3 log UI/ml"
],
"offsets": [
[
118,
132
]
],
"normalized": []
},
{
"id": "NCT03216967_inc_T8",
"type": "Measurement",
"text": [
"pregnancy test"
],
"offsets": [
[
191,
205
]
],
"normalized": []
},
{
"id": "NCT03216967_inc_T9",
"type": "Value",
"text": [
"Negative"
],
"offsets": [
[
182,
190
]
],
"normalized": []
},
{
"id": "NCT03216967_inc_T10",
"type": "Measurement",
"text": [
"blood ß-HCG dosage"
],
"offsets": [
[
207,
225
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03216967_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03216967_inc_T5",
"arg2_id": "NCT03216967_inc_T6",
"normalized": []
},
{
"id": "NCT03216967_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03216967_inc_T8",
"arg2_id": "NCT03216967_inc_T9",
"normalized": []
},
{
"id": "NCT03216967_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT03216967_inc_T8",
"arg2_id": "NCT03216967_inc_T10",
"normalized": []
}
] |
NCT03217409_exc | NCT03217409 | [
{
"id": "NCT03217409_exc_text",
"type": "exclusion",
"text": [
"Subjects with hypersensitivity reaction to Statin and Ezetimibe\nSubjects with severe kidney disease\nSubjects with HIV positive result at the screening\nPregnant or breast-feeding subjects\nSubjects with taking any medication affecting level of LDL (Fenofibrate, Omega 3 fatty aicd etc.)\nInsulin-treated Subjects\nOther exclusions applied\n"
],
"offsets": [
[
0,
335
]
]
}
] | [
{
"id": "NCT03217409_exc_T1",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
14,
30
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T2",
"type": "Drug",
"text": [
"Statin"
],
"offsets": [
[
43,
49
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T3",
"type": "Drug",
"text": [
"Ezetimibe"
],
"offsets": [
[
54,
63
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T4",
"type": "Scope",
"text": [
"Statin and Ezetimibe"
],
"offsets": [
[
43,
63
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T5",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
78,
84
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T6",
"type": "Condition",
"text": [
"kidney disease"
],
"offsets": [
[
85,
99
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T7",
"type": "Condition",
"text": [
"HIV positive"
],
"offsets": [
[
114,
126
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T8",
"type": "Temporal",
"text": [
"at the screening"
],
"offsets": [
[
134,
150
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T9",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
151,
159
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T10",
"type": "Condition",
"text": [
"breast-feeding"
],
"offsets": [
[
163,
177
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T11",
"type": "Procedure",
"text": [
"LDL"
],
"offsets": [
[
242,
245
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T12",
"type": "Drug",
"text": [
"Fenofibrate"
],
"offsets": [
[
247,
258
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T13",
"type": "Drug",
"text": [
"medication"
],
"offsets": [
[
212,
222
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T14",
"type": "Condition",
"text": [
"affecting"
],
"offsets": [
[
223,
232
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T15",
"type": "Drug",
"text": [
"Omega 3 fatty aicd"
],
"offsets": [
[
260,
278
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T16",
"type": "Scope",
"text": [
"Fenofibrate, Omega 3 fatty aicd"
],
"offsets": [
[
247,
278
]
],
"normalized": []
},
{
"id": "NCT03217409_exc_T17",
"type": "Drug",
"text": [
"Insulin"
],
"offsets": [
[
285,
292
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03217409_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT03217409_exc_T1",
"arg2_id": "NCT03217409_exc_T4",
"normalized": []
},
{
"id": "NCT03217409_exc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03217409_exc_T6",
"arg2_id": "NCT03217409_exc_T5",
"normalized": []
},
{
"id": "NCT03217409_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT03217409_exc_T7",
"arg2_id": "NCT03217409_exc_T8",
"normalized": []
},
{
"id": "NCT03217409_exc_R4",
"type": "AND",
"arg1_id": "NCT03217409_exc_T14",
"arg2_id": "NCT03217409_exc_T11",
"normalized": []
},
{
"id": "NCT03217409_exc_R5",
"type": "AND",
"arg1_id": "NCT03217409_exc_T13",
"arg2_id": "NCT03217409_exc_T14",
"normalized": []
},
{
"id": "NCT03217409_exc_R6",
"type": "Subsumes",
"arg1_id": "NCT03217409_exc_T13",
"arg2_id": "NCT03217409_exc_T16",
"normalized": []
}
] |
NCT03217409_inc | NCT03217409 | [
{
"id": "NCT03217409_inc_text",
"type": "inclusion",
"text": [
"Subjects = 19 or = 75 years of age\nSubjects undergoing treatment for type 2 diabetes\nSubjects undergoing treatment of statin for hypercholesterolemia\nFasting LDL-C = 250mg/dL at the screening visit\nFasting LDL-C =70mg/dL or = 160mg/dL at the randomization visit\nFasting TG<500mg/dL\n"
],
"offsets": [
[
0,
282
]
]
}
] | [
{
"id": "NCT03217409_inc_T1",
"type": "Value",
"text": [
"= 19 or = 75 years"
],
"offsets": [
[
9,
27
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T2",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
31,
34
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T3",
"type": "Condition",
"text": [
"type 2 diabetes"
],
"offsets": [
[
69,
84
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T4",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
55,
64
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T5",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
105,
114
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T6",
"type": "Condition",
"text": [
"hypercholesterolemia"
],
"offsets": [
[
129,
149
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T7",
"type": "Drug",
"text": [
"statin"
],
"offsets": [
[
118,
124
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T8",
"type": "Scope",
"text": [
"treatment of statin"
],
"offsets": [
[
105,
124
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T9",
"type": "Measurement",
"text": [
"Fasting LDL-C"
],
"offsets": [
[
150,
163
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T10",
"type": "Measurement",
"text": [
"Fasting LDL-C"
],
"offsets": [
[
198,
211
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T11",
"type": "Value",
"text": [
"= 250mg/dL"
],
"offsets": [
[
164,
174
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T12",
"type": "Temporal",
"text": [
"at the screening visit"
],
"offsets": [
[
175,
197
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T13",
"type": "Value",
"text": [
"=70mg/dL"
],
"offsets": [
[
212,
220
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T14",
"type": "Value",
"text": [
"= 160mg/dL"
],
"offsets": [
[
224,
234
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T15",
"type": "Scope",
"text": [
"=70mg/dL or = 160mg/d"
],
"offsets": [
[
212,
233
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T16",
"type": "Temporal",
"text": [
"at the randomization visit"
],
"offsets": [
[
235,
261
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T17",
"type": "Measurement",
"text": [
"Fasting TG"
],
"offsets": [
[
262,
272
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T18",
"type": "Value",
"text": [
"<500mg/dL"
],
"offsets": [
[
272,
281
]
],
"normalized": []
},
{
"id": "NCT03217409_inc_T19",
"type": "Temporal",
"text": [
"at the randomization visit"
],
"offsets": [
[
235,
261
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03217409_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03217409_inc_T2",
"arg2_id": "NCT03217409_inc_T1",
"normalized": []
},
{
"id": "NCT03217409_inc_R2",
"type": "AND",
"arg1_id": "NCT03217409_inc_T4",
"arg2_id": "NCT03217409_inc_T3",
"normalized": []
},
{
"id": "NCT03217409_inc_R3",
"type": "AND",
"arg1_id": "NCT03217409_inc_T5",
"arg2_id": "NCT03217409_inc_T7",
"normalized": []
},
{
"id": "NCT03217409_inc_R4",
"type": "AND",
"arg1_id": "NCT03217409_inc_T8",
"arg2_id": "NCT03217409_inc_T6",
"normalized": []
},
{
"id": "NCT03217409_inc_R5",
"type": "Has_value",
"arg1_id": "NCT03217409_inc_T9",
"arg2_id": "NCT03217409_inc_T11",
"normalized": []
},
{
"id": "NCT03217409_inc_R6",
"type": "Has_temporal",
"arg1_id": "NCT03217409_inc_T9",
"arg2_id": "NCT03217409_inc_T12",
"normalized": []
},
{
"id": "NCT03217409_inc_R7",
"type": "Has_scope",
"arg1_id": "NCT03217409_inc_T10",
"arg2_id": "NCT03217409_inc_T15",
"normalized": []
},
{
"id": "NCT03217409_inc_R8",
"type": "Has_temporal",
"arg1_id": "NCT03217409_inc_T10",
"arg2_id": "NCT03217409_inc_T16",
"normalized": []
},
{
"id": "NCT03217409_inc_R9",
"type": "Has_value",
"arg1_id": "NCT03217409_inc_T17",
"arg2_id": "NCT03217409_inc_T18",
"normalized": []
},
{
"id": "NCT03217409_inc_R10",
"type": "Has_temporal",
"arg1_id": "NCT03217409_inc_T10",
"arg2_id": "NCT03217409_inc_T19",
"normalized": []
}
] |
NCT03221231_exc | NCT03221231 | [
{
"id": "NCT03221231_exc_text",
"type": "exclusion",
"text": [
"Currently dependent on any substance other than cannabis, alcohol or nicotine;\nHistory of any major internal disease (including diabetes, cardiovascular disease, lung disease, liver or kidney disease);\nAn active or any history of neurological disorder, including but not limited to seizure disorder, epilepsy, stroke, neurological disease, cognitive impairment, head trauma with prolonged loss of consciousness (>10 minutes), or migraine headaches;\nAn active or a history of a psychiatric disorder including, but not limited to, depression, schizophrenia, bipolar disorder, anxiety, or other psychiatric disorders;\nAsthma;\nKnown hypersensitivity or allergy to n-acetylcysteine, or receiving chronic therapy with medication that could interact adversely with n-acetylcysteine within 30 days prior to randomization (i.e., nitroglycerin, ACE inhibitors or antihypertensive drugs, anti-coagulants);\nExclusion criteria for MRI: having metal in the body and/or having claustrophobia\n"
],
"offsets": [
[
0,
977
]
]
}
] | [
{
"id": "NCT03221231_exc_T1",
"type": "Condition",
"text": [
"dependent"
],
"offsets": [
[
10,
19
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T2",
"type": "Drug",
"text": [
"substance"
],
"offsets": [
[
27,
36
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T3",
"type": "Negation",
"text": [
"other than"
],
"offsets": [
[
37,
47
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T4",
"type": "Drug",
"text": [
"cannabis"
],
"offsets": [
[
48,
56
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T5",
"type": "Drug",
"text": [
"alcohol"
],
"offsets": [
[
58,
65
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T6",
"type": "Drug",
"text": [
"nicotine"
],
"offsets": [
[
69,
77
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T7",
"type": "Scope",
"text": [
"cannabis, alcohol or nicotine"
],
"offsets": [
[
48,
77
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T8",
"type": "Condition",
"text": [
"major internal disease"
],
"offsets": [
[
94,
116
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T9",
"type": "Condition",
"text": [
"diabetes"
],
"offsets": [
[
128,
136
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T10",
"type": "Condition",
"text": [
"cardiovascular disease"
],
"offsets": [
[
138,
160
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T11",
"type": "Condition",
"text": [
"lung disease"
],
"offsets": [
[
162,
174
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T12",
"type": "Condition",
"text": [
"kidney disease"
],
"offsets": [
[
185,
199
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T13",
"type": "Condition",
"text": [
"iver",
"isease)"
],
"offsets": [
[
177,
181
],
[
193,
200
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T14",
"type": "Scope",
"text": [
"diabetes, cardiovascular disease, lung disease, liver or kidney disease"
],
"offsets": [
[
128,
199
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T15",
"type": "Condition",
"text": [
"neurological disorder"
],
"offsets": [
[
230,
251
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T16",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
219,
226
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T17",
"type": "Qualifier",
"text": [
"active"
],
"offsets": [
[
205,
211
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T18",
"type": "Scope",
"text": [
"active or any history"
],
"offsets": [
[
205,
226
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T19",
"type": "Condition",
"text": [
"seizure disorder"
],
"offsets": [
[
282,
298
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T20",
"type": "Condition",
"text": [
"epilepsy"
],
"offsets": [
[
300,
308
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T21",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
310,
316
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T22",
"type": "Condition",
"text": [
"neurological disease"
],
"offsets": [
[
318,
338
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T23",
"type": "Condition",
"text": [
"cognitive impairment"
],
"offsets": [
[
340,
360
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T24",
"type": "Condition",
"text": [
"head trauma"
],
"offsets": [
[
362,
373
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T25",
"type": "Condition",
"text": [
"prolonged loss of consciousness"
],
"offsets": [
[
379,
410
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T26",
"type": "Qualifier",
"text": [
">10 minutes"
],
"offsets": [
[
412,
423
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T27",
"type": "Condition",
"text": [
"migraine headaches"
],
"offsets": [
[
429,
447
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T28",
"type": "Scope",
"text": [
"seizure disorder, epilepsy, stroke, neurological disease, cognitive impairment, head trauma with prolonged loss of consciousness (>10 minutes), or migraine headaches"
],
"offsets": [
[
282,
447
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T29",
"type": "Qualifier",
"text": [
"active"
],
"offsets": [
[
452,
458
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T30",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
464,
471
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T31",
"type": "Condition",
"text": [
"psychiatric disorder"
],
"offsets": [
[
477,
497
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T32",
"type": "Condition",
"text": [
"depression"
],
"offsets": [
[
529,
539
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T33",
"type": "Condition",
"text": [
"schizophrenia"
],
"offsets": [
[
541,
554
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T34",
"type": "Condition",
"text": [
"bipolar disorder"
],
"offsets": [
[
556,
572
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T35",
"type": "Condition",
"text": [
"anxiety"
],
"offsets": [
[
574,
581
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T36",
"type": "Condition",
"text": [
"psychiatric disorders"
],
"offsets": [
[
592,
613
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T37",
"type": "Qualifier",
"text": [
"other"
],
"offsets": [
[
586,
591
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T38",
"type": "Scope",
"text": [
"depression, schizophrenia, bipolar disorder, anxiety, or other psychiatric disorders"
],
"offsets": [
[
529,
613
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T39",
"type": "Scope",
"text": [
"active or a history"
],
"offsets": [
[
452,
471
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T40",
"type": "Condition",
"text": [
"Asthma"
],
"offsets": [
[
615,
621
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T41",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
629,
645
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T42",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
649,
656
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T43",
"type": "Drug",
"text": [
"n-acetylcysteine"
],
"offsets": [
[
660,
676
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T44",
"type": "Scope",
"text": [
"hypersensitivity or allergy"
],
"offsets": [
[
629,
656
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T45",
"type": "Procedure",
"text": [
"chronic therapy"
],
"offsets": [
[
691,
706
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T46",
"type": "Drug",
"text": [
"n-acetylcysteine"
],
"offsets": [
[
758,
774
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T47",
"type": "Temporal",
"text": [
"within 30 days prior to randomization"
],
"offsets": [
[
775,
812
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T48",
"type": "Drug",
"text": [
"nitroglycerin"
],
"offsets": [
[
820,
833
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T49",
"type": "Drug",
"text": [
"ACE inhibitors"
],
"offsets": [
[
835,
849
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T50",
"type": "Drug",
"text": [
"antihypertensive drugs"
],
"offsets": [
[
853,
875
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T51",
"type": "Drug",
"text": [
"anti-coagulants"
],
"offsets": [
[
877,
892
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T52",
"type": "Scope",
"text": [
"nitroglycerin, ACE inhibitors or antihypertensive drugs, anti-coagulants"
],
"offsets": [
[
820,
892
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T53",
"type": "Condition",
"text": [
"Exclusion criteria for MRI"
],
"offsets": [
[
895,
921
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T54",
"type": "Device",
"text": [
"metal in the body"
],
"offsets": [
[
930,
947
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T55",
"type": "Condition",
"text": [
"claustrophobia"
],
"offsets": [
[
962,
976
]
],
"normalized": []
},
{
"id": "NCT03221231_exc_T56",
"type": "Scope",
"text": [
"metal in the body and/or having claustrophobia"
],
"offsets": [
[
930,
976
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03221231_exc_R1",
"type": "Has_negation",
"arg1_id": "NCT03221231_exc_T7",
"arg2_id": "NCT03221231_exc_T3",
"normalized": []
},
{
"id": "NCT03221231_exc_R2",
"type": "Has_scope",
"arg1_id": "NCT03221231_exc_T2",
"arg2_id": "NCT03221231_exc_T7",
"normalized": []
},
{
"id": "NCT03221231_exc_R3",
"type": "AND",
"arg1_id": "NCT03221231_exc_T1",
"arg2_id": "NCT03221231_exc_T2",
"normalized": []
},
{
"id": "NCT03221231_exc_R4",
"type": "Subsumes",
"arg1_id": "NCT03221231_exc_T8",
"arg2_id": "NCT03221231_exc_T14",
"normalized": []
},
{
"id": "NCT03221231_exc_R5",
"type": "Has_scope",
"arg1_id": "NCT03221231_exc_T15",
"arg2_id": "NCT03221231_exc_T18",
"normalized": []
},
{
"id": "NCT03221231_exc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT03221231_exc_T25",
"arg2_id": "NCT03221231_exc_T26",
"normalized": []
},
{
"id": "NCT03221231_exc_R7",
"type": "AND",
"arg1_id": "NCT03221231_exc_T24",
"arg2_id": "NCT03221231_exc_T25",
"normalized": []
},
{
"id": "NCT03221231_exc_R8",
"type": "Subsumes",
"arg1_id": "NCT03221231_exc_T15",
"arg2_id": "NCT03221231_exc_T28",
"normalized": []
},
{
"id": "NCT03221231_exc_R9",
"type": "Has_qualifier",
"arg1_id": "NCT03221231_exc_T36",
"arg2_id": "NCT03221231_exc_T37",
"normalized": []
},
{
"id": "NCT03221231_exc_R10",
"type": "Subsumes",
"arg1_id": "NCT03221231_exc_T31",
"arg2_id": "NCT03221231_exc_T38",
"normalized": []
},
{
"id": "NCT03221231_exc_R11",
"type": "Has_scope",
"arg1_id": "NCT03221231_exc_T31",
"arg2_id": "NCT03221231_exc_T39",
"normalized": []
},
{
"id": "NCT03221231_exc_R12",
"type": "AND",
"arg1_id": "NCT03221231_exc_T44",
"arg2_id": "NCT03221231_exc_T43",
"normalized": []
},
{
"id": "NCT03221231_exc_R13",
"type": "AND",
"arg1_id": "NCT03221231_exc_T45",
"arg2_id": "NCT03221231_exc_T46",
"normalized": []
},
{
"id": "NCT03221231_exc_R14",
"type": "Has_temporal",
"arg1_id": "NCT03221231_exc_T45",
"arg2_id": "NCT03221231_exc_T47",
"normalized": []
},
{
"id": "NCT03221231_exc_R15",
"type": "Subsumes",
"arg1_id": "NCT03221231_exc_T45",
"arg2_id": "NCT03221231_exc_T52",
"normalized": []
},
{
"id": "NCT03221231_exc_R16",
"type": "Subsumes",
"arg1_id": "NCT03221231_exc_T53",
"arg2_id": "NCT03221231_exc_T56",
"normalized": []
}
] |
NCT03221231_inc | NCT03221231 | [
{
"id": "NCT03221231_inc_text",
"type": "inclusion",
"text": [
"Current DSM-IV diagnosis of cannabis dependence, >1 week detoxified and abstinent;\nAble to provide written informed consent and to comply with study procedures.\nDutch speaking (Dutch as primary language).\n"
],
"offsets": [
[
0,
205
]
]
}
] | [
{
"id": "NCT03221231_inc_T1",
"type": "Qualifier",
"text": [
"DSM-IV"
],
"offsets": [
[
8,
14
]
],
"normalized": []
},
{
"id": "NCT03221231_inc_T2",
"type": "Condition",
"text": [
"cannabis dependence"
],
"offsets": [
[
28,
47
]
],
"normalized": []
},
{
"id": "NCT03221231_inc_T3",
"type": "Multiplier",
"text": [
">1 week"
],
"offsets": [
[
49,
56
]
],
"normalized": []
},
{
"id": "NCT03221231_inc_T4",
"type": "Condition",
"text": [
"detoxified"
],
"offsets": [
[
57,
67
]
],
"normalized": []
},
{
"id": "NCT03221231_inc_T5",
"type": "Condition",
"text": [
"abstinent"
],
"offsets": [
[
72,
81
]
],
"normalized": []
},
{
"id": "NCT03221231_inc_T6",
"type": "Scope",
"text": [
"detoxified and abstinent"
],
"offsets": [
[
57,
81
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03221231_inc_R1",
"type": "Has_multiplier",
"arg1_id": "NCT03221231_inc_T6",
"arg2_id": "NCT03221231_inc_T3",
"normalized": []
},
{
"id": "NCT03221231_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03221231_inc_T2",
"arg2_id": "NCT03221231_inc_T1",
"normalized": []
}
] |
NCT03223909_exc | NCT03223909 | [
{
"id": "NCT03223909_exc_text",
"type": "exclusion",
"text": [
"Subjects with topical and/or systemic medication or mechanical devices that interfere determinedly on the results of the study (such as topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses).\nSubjects (females) with active sexual life that do not use a contraceptive method.\nFemale subjects who are pregnant or lactating\nFemale subjects with a positive urine pregnancy test\nPositive drug addictions* (verbal interrogatory)\nSubjects who have participated on any other research clinical trials on the last 40 days\nSubjects legal or mentally disabled to give an informed consent for participating on this study\nSubjects who can't comply with the appointments or with every protocol requirement.\nSerious tear film dysfunction syndrome TBUT < 5 s Schirmer: < 4 mm OSDI > 30 pints Corneal staining > grade III on the Oxford scale\nNon perforated corneal ulcer\nPerforated corneal ulcer\nAutoimmune corneal ulcer\nOcular surface scarring diseases\nOcular surface or annexes metaplastic lesions\nFibro vascular proliferation lesions on the conjunctival and/or corneal surface (i.e.: pterygium)\nConcomitant chronic inflammatory diseases on any ocular structure\nAcute or infectious inflammatory disease\nCorneal disease potentially requiring a treatment during the following 3 months\nUse of topical or systemic drug products classified as forbidden\nOcular surgical procedures 3 months before the protocol inclusion\nTreatments or procedures indicated on the tear film dysfunction treatment, as punctal silicone plugs.\nPosterior segment diseases requiring a treatment or threatening the visual prognosis\nRetinal diseases potentially requiring treatment during the following 3 months\nHistory of penetrating keratoplasty.\nSoft or hard contact lenses use during the last month from inclusion day\n"
],
"offsets": [
[
0,
1824
]
]
}
] | [
{
"id": "NCT03223909_exc_T1",
"type": "Drug",
"text": [
"systemic medication"
],
"offsets": [
[
29,
48
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T2",
"type": "Drug",
"text": [
"topical",
"medication"
],
"offsets": [
[
14,
21
],
[
38,
48
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T3",
"type": "Device",
"text": [
"mechanical devices"
],
"offsets": [
[
52,
70
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T4",
"type": "Drug",
"text": [
"topical immunomodulators"
],
"offsets": [
[
136,
160
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T5",
"type": "Device",
"text": [
"punctal plugs"
],
"offsets": [
[
162,
175
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T6",
"type": "Drug",
"text": [
"corticosteroids"
],
"offsets": [
[
177,
192
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T7",
"type": "Drug",
"text": [
"preservative artificial tears"
],
"offsets": [
[
194,
223
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T8",
"type": "Device",
"text": [
"contact lenses"
],
"offsets": [
[
225,
239
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T9",
"type": "Scope",
"text": [
"topical immunomodulators, punctal plugs, corticosteroids, preservative artificial tears, contact lenses"
],
"offsets": [
[
136,
239
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T10",
"type": "Scope",
"text": [
"topical and/or systemic medication or mechanical devices"
],
"offsets": [
[
14,
70
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T11",
"type": "Person",
"text": [
"females"
],
"offsets": [
[
252,
259
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T12",
"type": "Observation",
"text": [
"active sexual life"
],
"offsets": [
[
266,
284
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T13",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
293,
296
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T14",
"type": "Procedure",
"text": [
"contraceptive method"
],
"offsets": [
[
303,
323
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T15",
"type": "Person",
"text": [
"Female"
],
"offsets": [
[
325,
331
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T16",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
349,
357
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T17",
"type": "Condition",
"text": [
"lactating"
],
"offsets": [
[
361,
370
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T18",
"type": "Person",
"text": [
"Female"
],
"offsets": [
[
371,
377
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T19",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
394,
402
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T20",
"type": "Measurement",
"text": [
"urine pregnancy test"
],
"offsets": [
[
403,
423
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T21",
"type": "Condition",
"text": [
"Positive drug addictions"
],
"offsets": [
[
424,
448
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T22",
"type": "Procedure",
"text": [
"verbal interrogatory"
],
"offsets": [
[
451,
471
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T24",
"type": "Condition",
"text": [
"mentally disabled"
],
"offsets": [
[
580,
597
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T25",
"type": "Condition",
"text": [
"or me",
"ed to gi"
],
"offsets": [
[
577,
582
],
[
595,
603
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T28",
"type": "Condition",
"text": [
"Serious tear film dysfunction syndrome"
],
"offsets": [
[
742,
780
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T29",
"type": "Measurement",
"text": [
"TBUT"
],
"offsets": [
[
781,
785
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T31",
"type": "Value",
"text": [
"< 5 s"
],
"offsets": [
[
786,
791
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T32",
"type": "Measurement",
"text": [
"Schirmer"
],
"offsets": [
[
792,
800
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T33",
"type": "Value",
"text": [
"< 4 mm"
],
"offsets": [
[
802,
808
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T34",
"type": "Measurement",
"text": [
"OSDI"
],
"offsets": [
[
809,
813
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T35",
"type": "Value",
"text": [
"> 30 pints"
],
"offsets": [
[
814,
824
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T36",
"type": "Measurement",
"text": [
"Corneal staining"
],
"offsets": [
[
825,
841
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T37",
"type": "Value",
"text": [
"> grade III"
],
"offsets": [
[
842,
853
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T38",
"type": "Qualifier",
"text": [
"Oxford scale"
],
"offsets": [
[
861,
873
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T43",
"type": "Qualifier",
"text": [
"Non perforated"
],
"offsets": [
[
874,
888
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T44",
"type": "Condition",
"text": [
"corneal ulcer"
],
"offsets": [
[
889,
902
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T45",
"type": "Condition",
"text": [
"corneal ulcer"
],
"offsets": [
[
914,
927
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T46",
"type": "Qualifier",
"text": [
"Perforated"
],
"offsets": [
[
903,
913
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T47",
"type": "Condition",
"text": [
"corneal ulcer"
],
"offsets": [
[
939,
952
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T48",
"type": "Qualifier",
"text": [
"Autoimmune"
],
"offsets": [
[
928,
938
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T49",
"type": "Condition",
"text": [
"Ocular surface scarring diseases"
],
"offsets": [
[
953,
985
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T50",
"type": "Condition",
"text": [
" vascu",
"e or annexes m"
],
"offsets": [
[
1037,
1043
],
[
999,
1013
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T51",
"type": "Condition",
"text": [
"lastic lesions\nFibro vascul",
"e or a"
],
"offsets": [
[
1017,
1044
],
[
999,
1005
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T52",
"type": "Condition",
"text": [
"Fibro vascular proliferation lesions"
],
"offsets": [
[
1032,
1068
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T53",
"type": "Qualifier",
"text": [
"corneal surface"
],
"offsets": [
[
1096,
1111
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T54",
"type": "Qualifier",
"text": [
"conjunctival"
],
"offsets": [
[
1076,
1088
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T55",
"type": "Qualifier",
"text": [
"pterygium"
],
"offsets": [
[
1119,
1128
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T56",
"type": "Scope",
"text": [
"conjunctival and/or corneal surface"
],
"offsets": [
[
1076,
1111
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T57",
"type": "Temporal",
"text": [
"Concomitant"
],
"offsets": [
[
1130,
1141
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T58",
"type": "Condition",
"text": [
"chronic inflammatory diseases"
],
"offsets": [
[
1142,
1171
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T59",
"type": "Qualifier",
"text": [
"ocular structure"
],
"offsets": [
[
1179,
1195
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T60",
"type": "Condition",
"text": [
"inflammatory disease"
],
"offsets": [
[
1216,
1236
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T61",
"type": "Qualifier",
"text": [
"Acute"
],
"offsets": [
[
1196,
1201
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T62",
"type": "Qualifier",
"text": [
"infectious"
],
"offsets": [
[
1205,
1215
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T63",
"type": "Scope",
"text": [
"Acute or infectious"
],
"offsets": [
[
1196,
1215
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T64",
"type": "Condition",
"text": [
"Corneal disease"
],
"offsets": [
[
1237,
1252
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T65",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
1277,
1286
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T66",
"type": "Mood",
"text": [
"potentially requiring"
],
"offsets": [
[
1253,
1274
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T67",
"type": "Temporal",
"text": [
"during the following 3 months"
],
"offsets": [
[
1287,
1316
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T69",
"type": "Procedure",
"text": [
"Ocular surgical procedures"
],
"offsets": [
[
1382,
1408
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T70",
"type": "Temporal",
"text": [
"3 months before the protocol inclusion"
],
"offsets": [
[
1409,
1447
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T71",
"type": "Reference_point",
"text": [
"protocol inclusion"
],
"offsets": [
[
1429,
1447
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T72",
"type": "Temporal",
"text": [
"3 months before the protocol inclusion"
],
"offsets": [
[
1409,
1447
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T73",
"type": "Procedure",
"text": [
"Treatments"
],
"offsets": [
[
1448,
1458
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T74",
"type": "Procedure",
"text": [
"procedures"
],
"offsets": [
[
1462,
1472
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T75",
"type": "Procedure",
"text": [
"tear film dysfunction treatment"
],
"offsets": [
[
1490,
1521
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T76",
"type": "Device",
"text": [
"punctal silicone plugs"
],
"offsets": [
[
1526,
1548
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T77",
"type": "Scope",
"text": [
"Treatments or procedures"
],
"offsets": [
[
1448,
1472
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T78",
"type": "Condition",
"text": [
"Posterior segment diseases"
],
"offsets": [
[
1550,
1576
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T79",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
1589,
1598
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T80",
"type": "Condition",
"text": [
"threatening the visual prognosis"
],
"offsets": [
[
1602,
1634
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T81",
"type": "Mood",
"text": [
"requiring"
],
"offsets": [
[
1577,
1586
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T82",
"type": "Scope",
"text": [
"requiring a treatment or threatening the visual prognosis"
],
"offsets": [
[
1577,
1634
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T83",
"type": "Device",
"text": [
"hard contact lenses"
],
"offsets": [
[
1759,
1778
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T84",
"type": "Procedure",
"text": [
"penetrating keratoplasty"
],
"offsets": [
[
1725,
1749
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T85",
"type": "Temporal",
"text": [
"during the following 3 months"
],
"offsets": [
[
1684,
1713
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T86",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
1674,
1683
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T87",
"type": "Mood",
"text": [
"requiring"
],
"offsets": [
[
1664,
1673
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T88",
"type": "Condition",
"text": [
"Retinal diseases"
],
"offsets": [
[
1635,
1651
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T89",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
1714,
1721
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T90",
"type": "Device",
"text": [
"ses",
"g the last mon"
],
"offsets": [
[
1775,
1778
],
[
1788,
1802
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T91",
"type": "Temporal",
"text": [
"during the last month from inclusion day"
],
"offsets": [
[
1783,
1823
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T92",
"type": "Reference_point",
"text": [
"inclusion day"
],
"offsets": [
[
1810,
1823
]
],
"normalized": []
},
{
"id": "NCT03223909_exc_T93",
"type": "Scope",
"text": [
"Soft or hard contact lenses"
],
"offsets": [
[
1751,
1778
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03223909_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT03223909_exc_T10",
"arg2_id": "NCT03223909_exc_T9",
"normalized": []
},
{
"id": "NCT03223909_exc_R2",
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"arg2_id": "NCT03223909_exc_T13",
"normalized": []
},
{
"id": "NCT03223909_exc_R3",
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"normalized": []
},
{
"id": "NCT03223909_exc_R4",
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"normalized": []
},
{
"id": "NCT03223909_exc_R5",
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"normalized": []
},
{
"id": "NCT03223909_exc_R6",
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"arg2_id": "NCT03223909_exc_T33",
"normalized": []
},
{
"id": "NCT03223909_exc_R7",
"type": "Has_qualifier",
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"arg2_id": "NCT03223909_exc_T38",
"normalized": []
},
{
"id": "NCT03223909_exc_R8",
"type": "Has_value",
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"arg2_id": "NCT03223909_exc_T37",
"normalized": []
},
{
"id": "NCT03223909_exc_R9",
"type": "Has_value",
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"arg2_id": "NCT03223909_exc_T35",
"normalized": []
},
{
"id": "NCT03223909_exc_R10",
"type": "Has_qualifier",
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"arg2_id": "NCT03223909_exc_T43",
"normalized": []
},
{
"id": "NCT03223909_exc_R11",
"type": "Has_qualifier",
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"arg2_id": "NCT03223909_exc_T46",
"normalized": []
},
{
"id": "NCT03223909_exc_R12",
"type": "Has_qualifier",
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"arg2_id": "NCT03223909_exc_T48",
"normalized": []
},
{
"id": "NCT03223909_exc_R13",
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"arg2_id": "NCT03223909_exc_T55",
"normalized": []
},
{
"id": "NCT03223909_exc_R14",
"type": "Has_scope",
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"arg2_id": "NCT03223909_exc_T56",
"normalized": []
},
{
"id": "NCT03223909_exc_R15",
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"arg2_id": "NCT03223909_exc_T59",
"normalized": []
},
{
"id": "NCT03223909_exc_R16",
"type": "Has_temporal",
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"normalized": []
},
{
"id": "NCT03223909_exc_R17",
"type": "Has_scope",
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"normalized": []
},
{
"id": "NCT03223909_exc_R18",
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"arg2_id": "NCT03223909_exc_T66",
"normalized": []
},
{
"id": "NCT03223909_exc_R19",
"type": "AND",
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"normalized": []
},
{
"id": "NCT03223909_exc_R20",
"type": "Has_temporal",
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"arg2_id": "NCT03223909_exc_T67",
"normalized": []
},
{
"id": "NCT03223909_exc_R21",
"type": "Has_index",
"arg1_id": "NCT03223909_exc_T72",
"arg2_id": "NCT03223909_exc_T71",
"normalized": []
},
{
"id": "NCT03223909_exc_R22",
"type": "Has_temporal",
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"arg2_id": "NCT03223909_exc_T72",
"normalized": []
},
{
"id": "NCT03223909_exc_R23",
"type": "Has_scope",
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"arg2_id": "NCT03223909_exc_T77",
"normalized": []
},
{
"id": "NCT03223909_exc_R24",
"type": "AND",
"arg1_id": "NCT03223909_exc_T75",
"arg2_id": "NCT03223909_exc_T76",
"normalized": []
},
{
"id": "NCT03223909_exc_R25",
"type": "Has_mood",
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"arg2_id": "NCT03223909_exc_T81",
"normalized": []
},
{
"id": "NCT03223909_exc_R26",
"type": "Has_scope",
"arg1_id": "NCT03223909_exc_T78",
"arg2_id": "NCT03223909_exc_T82",
"normalized": []
},
{
"id": "NCT03223909_exc_R27",
"type": "Has_mood",
"arg1_id": "NCT03223909_exc_T86",
"arg2_id": "NCT03223909_exc_T87",
"normalized": []
},
{
"id": "NCT03223909_exc_R28",
"type": "Has_temporal",
"arg1_id": "NCT03223909_exc_T86",
"arg2_id": "NCT03223909_exc_T85",
"normalized": []
},
{
"id": "NCT03223909_exc_R29",
"type": "AND",
"arg1_id": "NCT03223909_exc_T88",
"arg2_id": "NCT03223909_exc_T86",
"normalized": []
},
{
"id": "NCT03223909_exc_R30",
"type": "Has_temporal",
"arg1_id": "NCT03223909_exc_T84",
"arg2_id": "NCT03223909_exc_T89",
"normalized": []
},
{
"id": "NCT03223909_exc_R31",
"type": "Has_index",
"arg1_id": "NCT03223909_exc_T91",
"arg2_id": "NCT03223909_exc_T92",
"normalized": []
},
{
"id": "NCT03223909_exc_R32",
"type": "Has_temporal",
"arg1_id": "NCT03223909_exc_T93",
"arg2_id": "NCT03223909_exc_T91",
"normalized": []
}
] |
NCT03223909_inc | NCT03223909 | [
{
"id": "NCT03223909_inc_text",
"type": "inclusion",
"text": [
">18 to < 90 years old\nBoth sexes\nMild to moderate tear film dysfunction clinical diagnose\nTBUT > 5 sec. and < 10 sec.\nSchirmer: > 4 mm and < 14 mm\nOSDI < 30 points\nCorneal staining < grade III on the Oxford scale\nAvailability to go to each revision when indicated.\n"
],
"offsets": [
[
0,
265
]
]
}
] | [
{
"id": "NCT03223909_inc_T1",
"type": "Person",
"text": [
"old"
],
"offsets": [
[
18,
21
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T2",
"type": "Value",
"text": [
">18 to < 90 years"
],
"offsets": [
[
0,
17
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T3",
"type": "Person",
"text": [
"Both sexes"
],
"offsets": [
[
22,
32
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T4",
"type": "Qualifier",
"text": [
"moderate"
],
"offsets": [
[
41,
49
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T5",
"type": "Qualifier",
"text": [
"Mild"
],
"offsets": [
[
33,
37
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T6",
"type": "Condition",
"text": [
"tear film dysfunction"
],
"offsets": [
[
50,
71
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T7",
"type": "Scope",
"text": [
"Mild to moderate"
],
"offsets": [
[
33,
49
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T8",
"type": "Measurement",
"text": [
"TBUT"
],
"offsets": [
[
90,
94
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T9",
"type": "Value",
"text": [
"> 5 sec. and < 10 sec"
],
"offsets": [
[
95,
116
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T10",
"type": "Measurement",
"text": [
"Schirmer"
],
"offsets": [
[
118,
126
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T11",
"type": "Value",
"text": [
"> 4 mm and < 14 mm"
],
"offsets": [
[
128,
146
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T12",
"type": "Measurement",
"text": [
"OSDI"
],
"offsets": [
[
147,
151
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T13",
"type": "Value",
"text": [
"< 30 points"
],
"offsets": [
[
152,
163
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T14",
"type": "Condition",
"text": [
"Corneal staining"
],
"offsets": [
[
164,
180
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T15",
"type": "Qualifier",
"text": [
"< grade III"
],
"offsets": [
[
181,
192
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T16",
"type": "Qualifier",
"text": [
"Oxford scale"
],
"offsets": [
[
200,
212
]
],
"normalized": []
},
{
"id": "NCT03223909_inc_T17",
"type": "Qualifier",
"text": [
"Oxford scale"
],
"offsets": [
[
200,
212
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03223909_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03223909_inc_T1",
"arg2_id": "NCT03223909_inc_T2",
"normalized": []
},
{
"id": "NCT03223909_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT03223909_inc_T6",
"arg2_id": "NCT03223909_inc_T7",
"normalized": []
},
{
"id": "NCT03223909_inc_R3",
"type": "Has_value",
"arg1_id": "NCT03223909_inc_T8",
"arg2_id": "NCT03223909_inc_T9",
"normalized": []
},
{
"id": "NCT03223909_inc_R4",
"type": "Has_value",
"arg1_id": "NCT03223909_inc_T10",
"arg2_id": "NCT03223909_inc_T11",
"normalized": []
},
{
"id": "NCT03223909_inc_R5",
"type": "Has_value",
"arg1_id": "NCT03223909_inc_T12",
"arg2_id": "NCT03223909_inc_T13",
"normalized": []
},
{
"id": "NCT03223909_inc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT03223909_inc_T15",
"arg2_id": "NCT03223909_inc_T16",
"normalized": []
},
{
"id": "NCT03223909_inc_R7",
"type": "Has_qualifier",
"arg1_id": "NCT03223909_inc_T14",
"arg2_id": "NCT03223909_inc_T15",
"normalized": []
},
{
"id": "NCT03223909_inc_R8",
"type": "Has_qualifier",
"arg1_id": "NCT03223909_inc_T15",
"arg2_id": "NCT03223909_inc_T17",
"normalized": []
}
] |
NCT03225469_exc | NCT03225469 | [
{
"id": "NCT03225469_exc_text",
"type": "exclusion",
"text": [
"1. History of colorectal surgery \n2. Suspected or known digestive tract obstruction, stricture, or perforation \n3. Serious status of illness, such as severe renal failure whose creatinine clearance<30 ml/min, New York Heart Association grade III or grade IV congestive heart failure, or hemodynamic instability, etc. \n4. Incapable of completing bowel preparation，such as dysphagia, allergy to purgatives, or impaired mental status, etc. \n5. Pregnancy or breastfeeding \n6. Incomplete colonoscopy due to causes except poor bowel preparation \n7. Unable to give informed consent \n8. Have participated in the study before. \n \n"
],
"offsets": [
[
0,
630
]
]
}
] | [
{
"id": "NCT03225469_exc_T1",
"type": "Procedure",
"text": [
"colorectal surgery"
],
"offsets": [
[
14,
32
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T2",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
3,
10
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T3",
"type": "Condition",
"text": [
"digestive tract obstruction"
],
"offsets": [
[
56,
83
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T4",
"type": "Condition",
"text": [
"digestive tract",
"stricture"
],
"offsets": [
[
56,
71
],
[
85,
94
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T5",
"type": "Condition",
"text": [
"digestive tract",
"perforation"
],
"offsets": [
[
56,
71
],
[
99,
110
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T9",
"type": "Condition",
"text": [
"renal failure"
],
"offsets": [
[
157,
170
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T10",
"type": "Measurement",
"text": [
"creatinine clearance"
],
"offsets": [
[
177,
197
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T11",
"type": "Value",
"text": [
"<30 ml/min"
],
"offsets": [
[
197,
207
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T12",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
150,
156
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T13",
"type": "Measurement",
"text": [
"New York Heart Association"
],
"offsets": [
[
209,
235
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T14",
"type": "Value",
"text": [
"grade III or grade IV"
],
"offsets": [
[
236,
257
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T15",
"type": "Condition",
"text": [
"congestive heart failure"
],
"offsets": [
[
258,
282
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T16",
"type": "Condition",
"text": [
"hemodynamic instability"
],
"offsets": [
[
287,
310
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T19",
"type": "Scope",
"text": [
"severe renal failure whose creatinine clearance<30 ml/min, New York Heart Association grade III or grade IV congestive heart failure, or hemodynamic instability"
],
"offsets": [
[
150,
310
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T20",
"type": "Condition",
"text": [
"Serious status of illness"
],
"offsets": [
[
115,
140
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T22",
"type": "Condition",
"text": [
"Incapable of completing bowel preparation"
],
"offsets": [
[
321,
362
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T23",
"type": "Condition",
"text": [
"dysphagia"
],
"offsets": [
[
371,
380
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T24",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
382,
389
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T25",
"type": "Drug",
"text": [
"purgatives"
],
"offsets": [
[
393,
403
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T26",
"type": "Condition",
"text": [
"impaired mental status"
],
"offsets": [
[
408,
430
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T27",
"type": "Scope",
"text": [
"dysphagia, allergy to purgatives, or impaired mental status"
],
"offsets": [
[
371,
430
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T29",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
441,
450
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T30",
"type": "Observation",
"text": [
"breastfeeding"
],
"offsets": [
[
454,
467
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T32",
"type": "Procedure",
"text": [
"colonoscopy"
],
"offsets": [
[
483,
494
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T33",
"type": "Condition",
"text": [
"poor bowel preparation"
],
"offsets": [
[
516,
538
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T34",
"type": "Negation",
"text": [
"except"
],
"offsets": [
[
509,
515
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T35",
"type": "Qualifier",
"text": [
"Incomplete"
],
"offsets": [
[
472,
482
]
],
"normalized": []
},
{
"id": "NCT03225469_exc_T40",
"type": "Observation",
"text": [
"informed consent"
],
"offsets": [
[
558,
574
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03225469_exc_R1",
"type": "Has_temporal",
"arg1_id": "NCT03225469_exc_T1",
"arg2_id": "NCT03225469_exc_T2",
"normalized": []
},
{
"id": "NCT03225469_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03225469_exc_T10",
"arg2_id": "NCT03225469_exc_T11",
"normalized": []
},
{
"id": "NCT03225469_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT03225469_exc_T9",
"arg2_id": "NCT03225469_exc_T12",
"normalized": []
},
{
"id": "NCT03225469_exc_R4",
"type": "Has_value",
"arg1_id": "NCT03225469_exc_T13",
"arg2_id": "NCT03225469_exc_T14",
"normalized": []
},
{
"id": "NCT03225469_exc_R5",
"type": "AND",
"arg1_id": "NCT03225469_exc_T15",
"arg2_id": "NCT03225469_exc_T13",
"normalized": []
},
{
"id": "NCT03225469_exc_R6",
"type": "Subsumes",
"arg1_id": "NCT03225469_exc_T12",
"arg2_id": "NCT03225469_exc_T10",
"normalized": []
},
{
"id": "NCT03225469_exc_R7",
"type": "Subsumes",
"arg1_id": "NCT03225469_exc_T20",
"arg2_id": "NCT03225469_exc_T19",
"normalized": []
},
{
"id": "NCT03225469_exc_R8",
"type": "AND",
"arg1_id": "NCT03225469_exc_T24",
"arg2_id": "NCT03225469_exc_T25",
"normalized": []
},
{
"id": "NCT03225469_exc_R9",
"type": "Has_scope",
"arg1_id": "NCT03225469_exc_T22",
"arg2_id": "NCT03225469_exc_T27",
"normalized": []
},
{
"id": "NCT03225469_exc_R10",
"type": "Has_negation",
"arg1_id": "NCT03225469_exc_T33",
"arg2_id": "NCT03225469_exc_T34",
"normalized": []
},
{
"id": "NCT03225469_exc_R11",
"type": "Has_qualifier",
"arg1_id": "NCT03225469_exc_T32",
"arg2_id": "NCT03225469_exc_T35",
"normalized": []
},
{
"id": "NCT03225469_exc_R12",
"type": "AND",
"arg1_id": "NCT03225469_exc_T32",
"arg2_id": "NCT03225469_exc_T33",
"normalized": []
}
] |
NCT03225469_inc | NCT03225469 | [
{
"id": "NCT03225469_inc_text",
"type": "inclusion",
"text": [
"1. Individuals scheduled for undergoing colonoscopy at the Endoscopy Center of Wuxi people's Hospital in China \n2. Greater than the age of 18 \n3. Individuals living with other family members \n4. Outpatients \n"
],
"offsets": [
[
0,
208
]
]
}
] | [
{
"id": "NCT03225469_inc_T1",
"type": "Visit",
"text": [
"Endoscopy Center of Wuxi people's Hospital in China"
],
"offsets": [
[
59,
110
]
],
"normalized": []
},
{
"id": "NCT03225469_inc_T2",
"type": "Procedure",
"text": [
"colonoscopy"
],
"offsets": [
[
40,
51
]
],
"normalized": []
},
{
"id": "NCT03225469_inc_T6",
"type": "Value",
"text": [
"Greater than",
"18"
],
"offsets": [
[
115,
127
],
[
139,
141
]
],
"normalized": []
},
{
"id": "NCT03225469_inc_T7",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
132,
135
]
],
"normalized": []
},
{
"id": "NCT03225469_inc_T11",
"type": "Visit",
"text": [
"Outpatients"
],
"offsets": [
[
195,
206
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03225469_inc_R2",
"type": "AND",
"arg1_id": "NCT03225469_inc_T2",
"arg2_id": "NCT03225469_inc_T1",
"normalized": []
},
{
"id": "NCT03225469_inc_R3",
"type": "Has_value",
"arg1_id": "NCT03225469_inc_T7",
"arg2_id": "NCT03225469_inc_T6",
"normalized": []
}
] |
NCT03226080_exc | NCT03226080 | [
{
"id": "NCT03226080_exc_text",
"type": "exclusion",
"text": [
"Inability to consent/refusal Allergy to any of the study medications Multiple traumatic injuries Contraindication to neuraxial or general anesthesia Pregnancy\n"
],
"offsets": [
[
0,
159
]
]
}
] | [
{
"id": "NCT03226080_exc_T1",
"type": "Observation",
"text": [
"Inability to consent"
],
"offsets": [
[
0,
20
]
],
"normalized": []
},
{
"id": "NCT03226080_exc_T2",
"type": "Observation",
"text": [
"refusal"
],
"offsets": [
[
21,
28
]
],
"normalized": []
},
{
"id": "NCT03226080_exc_T8",
"type": "Condition",
"text": [
"Allergy"
],
"offsets": [
[
29,
36
]
],
"normalized": []
},
{
"id": "NCT03226080_exc_T9",
"type": "Drug",
"text": [
"study medications"
],
"offsets": [
[
51,
68
]
],
"normalized": []
},
{
"id": "NCT03226080_exc_T10",
"type": "Condition",
"text": [
"Multiple traumatic injuries"
],
"offsets": [
[
69,
96
]
],
"normalized": []
},
{
"id": "NCT03226080_exc_T11",
"type": "Condition",
"text": [
"Contraindication"
],
"offsets": [
[
97,
113
]
],
"normalized": []
},
{
"id": "NCT03226080_exc_T12",
"type": "Procedure",
"text": [
"neuraxial",
"anesthesia"
],
"offsets": [
[
117,
126
],
[
138,
148
]
],
"normalized": []
},
{
"id": "NCT03226080_exc_T13",
"type": "Procedure",
"text": [
"general anesthesia"
],
"offsets": [
[
130,
148
]
],
"normalized": []
},
{
"id": "NCT03226080_exc_T14",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
149,
158
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03226080_exc_R1",
"type": "AND",
"arg1_id": "NCT03226080_exc_T8",
"arg2_id": "NCT03226080_exc_T9",
"normalized": []
}
] |
NCT03226080_inc | NCT03226080 | [
{
"id": "NCT03226080_inc_text",
"type": "inclusion",
"text": [
"ASA I-IV Age 55 or older Scheduled for operative repair of isolated intertrochanteric hip fracture\n"
],
"offsets": [
[
0,
99
]
]
}
] | [
{
"id": "NCT03226080_inc_T1",
"type": "Measurement",
"text": [
"ASA"
],
"offsets": [
[
0,
3
]
],
"normalized": []
},
{
"id": "NCT03226080_inc_T2",
"type": "Value",
"text": [
"I-IV"
],
"offsets": [
[
4,
8
]
],
"normalized": []
},
{
"id": "NCT03226080_inc_T3",
"type": "Person",
"text": [
"Age"
],
"offsets": [
[
9,
12
]
],
"normalized": []
},
{
"id": "NCT03226080_inc_T4",
"type": "Value",
"text": [
"55 or older"
],
"offsets": [
[
13,
24
]
],
"normalized": []
},
{
"id": "NCT03226080_inc_T5",
"type": "Mood",
"text": [
"Scheduled for"
],
"offsets": [
[
25,
38
]
],
"normalized": []
},
{
"id": "NCT03226080_inc_T6",
"type": "Procedure",
"text": [
"operative repair"
],
"offsets": [
[
39,
55
]
],
"normalized": []
},
{
"id": "NCT03226080_inc_T7",
"type": "Qualifier",
"text": [
"isolated"
],
"offsets": [
[
59,
67
]
],
"normalized": []
},
{
"id": "NCT03226080_inc_T8",
"type": "Condition",
"text": [
"intertrochanteric hip fracture"
],
"offsets": [
[
68,
98
]
],
"normalized": []
},
{
"id": "NCT03226080_inc_T9",
"type": "Multiplier",
"text": [
"isolated"
],
"offsets": [
[
59,
67
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03226080_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03226080_inc_T3",
"arg2_id": "NCT03226080_inc_T4",
"normalized": []
},
{
"id": "NCT03226080_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03226080_inc_T8",
"arg2_id": "NCT03226080_inc_T7",
"normalized": []
},
{
"id": "NCT03226080_inc_R3",
"type": "AND",
"arg1_id": "NCT03226080_inc_T6",
"arg2_id": "NCT03226080_inc_T8",
"normalized": []
},
{
"id": "NCT03226080_inc_R5",
"type": "Has_mood",
"arg1_id": "NCT03226080_inc_T6",
"arg2_id": "NCT03226080_inc_T5",
"normalized": []
},
{
"id": "NCT03226080_inc_R6",
"type": "Has_value",
"arg1_id": "NCT03226080_inc_T1",
"arg2_id": "NCT03226080_inc_T2",
"normalized": []
}
] |
NCT03228017_exc | NCT03228017 | [
{
"id": "NCT03228017_exc_text",
"type": "exclusion",
"text": [
"Unable to speak Spanish or English\nActive smoking (within the past year)\nAutoimmune, rheumatologic or inflammatory disease which are not psoriasis or psoriatic arthritis\nKnown active cancer receiving treatment\nPregnancy\nAnemia (hemoglobin < 9 mg/dl) or thrombocytopenia (Platelet count <75), or thrombocytosis (Platelet count >600)\nA history of severe bleeding or bleeding disorders\nCurrent medication use which interact with either aspirin or atorvastatin\nChronic kidney disease (CrCl < 30ml/min)\nCongestive heart failure\nCurrently taking aspirin or a statin.\nNSAID use within the past 48 hours\n"
],
"offsets": [
[
0,
596
]
]
}
] | [
{
"id": "NCT03228017_exc_T2",
"type": "Qualifier",
"text": [
"Active"
],
"offsets": [
[
35,
41
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T3",
"type": "Observation",
"text": [
"smoking"
],
"offsets": [
[
42,
49
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T4",
"type": "Value",
"text": [
"within the past year"
],
"offsets": [
[
51,
71
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T5",
"type": "Condition",
"text": [
"sease w",
"toimmune,"
],
"offsets": [
[
117,
124
],
[
75,
84
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T6",
"type": "Condition",
"text": [
"inflammatory disease"
],
"offsets": [
[
102,
122
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T7",
"type": "Condition",
"text": [
"sease w",
"eumatologic o"
],
"offsets": [
[
117,
124
],
[
87,
100
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T8",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
133,
136
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T9",
"type": "Condition",
"text": [
"psoriasis"
],
"offsets": [
[
137,
146
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T10",
"type": "Condition",
"text": [
"psoriatic arthritis"
],
"offsets": [
[
150,
169
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T11",
"type": "Scope",
"text": [
"psoriasis or psoriatic arthritis"
],
"offsets": [
[
137,
169
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T12",
"type": "Scope",
"text": [
"Autoimmune, rheumatologic or inflammatory disease"
],
"offsets": [
[
73,
122
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T13",
"type": "Condition",
"text": [
"cancer"
],
"offsets": [
[
183,
189
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T14",
"type": "Qualifier",
"text": [
"active"
],
"offsets": [
[
176,
182
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T15",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
200,
209
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T16",
"type": "Condition",
"text": [
"Pregnancy"
],
"offsets": [
[
210,
219
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T17",
"type": "Condition",
"text": [
"Anemia"
],
"offsets": [
[
220,
226
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T18",
"type": "Measurement",
"text": [
"hemoglobin"
],
"offsets": [
[
228,
238
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T19",
"type": "Value",
"text": [
"< 9 mg/dl"
],
"offsets": [
[
239,
248
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T20",
"type": "Condition",
"text": [
"thrombocytopenia"
],
"offsets": [
[
253,
269
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T21",
"type": "Measurement",
"text": [
"Platelet count"
],
"offsets": [
[
271,
285
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T22",
"type": "Value",
"text": [
"<75"
],
"offsets": [
[
286,
289
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T23",
"type": "Condition",
"text": [
"thrombocytosis"
],
"offsets": [
[
295,
309
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T24",
"type": "Measurement",
"text": [
"Platelet count"
],
"offsets": [
[
311,
325
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T25",
"type": "Value",
"text": [
">600"
],
"offsets": [
[
326,
330
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T26",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
334,
341
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T27",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
345,
351
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T28",
"type": "Condition",
"text": [
"bleeding"
],
"offsets": [
[
352,
360
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T29",
"type": "Condition",
"text": [
"bleeding disorders"
],
"offsets": [
[
364,
382
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T30",
"type": "Scope",
"text": [
"severe bleeding or bleeding disorders"
],
"offsets": [
[
345,
382
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T31",
"type": "Temporal",
"text": [
"Current"
],
"offsets": [
[
383,
390
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T32",
"type": "Drug",
"text": [
"medication"
],
"offsets": [
[
391,
401
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T33",
"type": "Drug",
"text": [
"aspirin"
],
"offsets": [
[
433,
440
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T34",
"type": "Drug",
"text": [
"atorvastatin"
],
"offsets": [
[
444,
456
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T35",
"type": "Condition",
"text": [
"interact"
],
"offsets": [
[
412,
420
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T36",
"type": "Scope",
"text": [
"aspirin or atorvastatin"
],
"offsets": [
[
433,
456
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T37",
"type": "Condition",
"text": [
"Chronic kidney disease"
],
"offsets": [
[
457,
479
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T38",
"type": "Measurement",
"text": [
"CrCl"
],
"offsets": [
[
481,
485
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T39",
"type": "Value",
"text": [
"< 30ml/min"
],
"offsets": [
[
486,
496
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T40",
"type": "Condition",
"text": [
"Congestive heart failure"
],
"offsets": [
[
498,
522
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T41",
"type": "Drug",
"text": [
"aspirin"
],
"offsets": [
[
540,
547
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T42",
"type": "Drug",
"text": [
"statin"
],
"offsets": [
[
553,
559
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T43",
"type": "Drug",
"text": [
"NSAID"
],
"offsets": [
[
561,
566
]
],
"normalized": []
},
{
"id": "NCT03228017_exc_T44",
"type": "Temporal",
"text": [
"within the past 48 hours"
],
"offsets": [
[
571,
595
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03228017_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03228017_exc_T3",
"arg2_id": "NCT03228017_exc_T2",
"normalized": []
},
{
"id": "NCT03228017_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03228017_exc_T3",
"arg2_id": "NCT03228017_exc_T4",
"normalized": []
},
{
"id": "NCT03228017_exc_R3",
"type": "Has_negation",
"arg1_id": "NCT03228017_exc_T11",
"arg2_id": "NCT03228017_exc_T8",
"normalized": []
},
{
"id": "NCT03228017_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT03228017_exc_T12",
"arg2_id": "NCT03228017_exc_T11",
"normalized": []
},
{
"id": "NCT03228017_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT03228017_exc_T13",
"arg2_id": "NCT03228017_exc_T14",
"normalized": []
},
{
"id": "NCT03228017_exc_R6",
"type": "AND",
"arg1_id": "NCT03228017_exc_T13",
"arg2_id": "NCT03228017_exc_T15",
"normalized": []
},
{
"id": "NCT03228017_exc_R7",
"type": "Has_value",
"arg1_id": "NCT03228017_exc_T18",
"arg2_id": "NCT03228017_exc_T19",
"normalized": []
},
{
"id": "NCT03228017_exc_R8",
"type": "Has_value",
"arg1_id": "NCT03228017_exc_T21",
"arg2_id": "NCT03228017_exc_T22",
"normalized": []
},
{
"id": "NCT03228017_exc_R9",
"type": "Has_value",
"arg1_id": "NCT03228017_exc_T24",
"arg2_id": "NCT03228017_exc_T25",
"normalized": []
},
{
"id": "NCT03228017_exc_R10",
"type": "Subsumes",
"arg1_id": "NCT03228017_exc_T23",
"arg2_id": "NCT03228017_exc_T24",
"normalized": []
},
{
"id": "NCT03228017_exc_R11",
"type": "Subsumes",
"arg1_id": "NCT03228017_exc_T20",
"arg2_id": "NCT03228017_exc_T21",
"normalized": []
},
{
"id": "NCT03228017_exc_R12",
"type": "Subsumes",
"arg1_id": "NCT03228017_exc_T17",
"arg2_id": "NCT03228017_exc_T18",
"normalized": []
},
{
"id": "NCT03228017_exc_R13",
"type": "Has_qualifier",
"arg1_id": "NCT03228017_exc_T28",
"arg2_id": "NCT03228017_exc_T27",
"normalized": []
},
{
"id": "NCT03228017_exc_R14",
"type": "Has_temporal",
"arg1_id": "NCT03228017_exc_T30",
"arg2_id": "NCT03228017_exc_T26",
"normalized": []
},
{
"id": "NCT03228017_exc_R15",
"type": "Subsumes",
"arg1_id": "NCT03228017_exc_T35",
"arg2_id": "NCT03228017_exc_T36",
"normalized": []
},
{
"id": "NCT03228017_exc_R16",
"type": "AND",
"arg1_id": "NCT03228017_exc_T32",
"arg2_id": "NCT03228017_exc_T35",
"normalized": []
},
{
"id": "NCT03228017_exc_R17",
"type": "Has_temporal",
"arg1_id": "NCT03228017_exc_T32",
"arg2_id": "NCT03228017_exc_T31",
"normalized": []
},
{
"id": "NCT03228017_exc_R18",
"type": "Has_value",
"arg1_id": "NCT03228017_exc_T38",
"arg2_id": "NCT03228017_exc_T39",
"normalized": []
},
{
"id": "NCT03228017_exc_R19",
"type": "Subsumes",
"arg1_id": "NCT03228017_exc_T37",
"arg2_id": "NCT03228017_exc_T38",
"normalized": []
},
{
"id": "NCT03228017_exc_R20",
"type": "Has_temporal",
"arg1_id": "NCT03228017_exc_T43",
"arg2_id": "NCT03228017_exc_T44",
"normalized": []
}
] |
NCT03228017_inc | NCT03228017 | [
{
"id": "NCT03228017_inc_text",
"type": "inclusion",
"text": [
"Subjects with a history of moderate to severe psoriatic disease\nGroup 2: Healthy subjects without known psoriatic disease or cardiovascular disease\n"
],
"offsets": [
[
0,
148
]
]
}
] | [
{
"id": "NCT03228017_inc_T1",
"type": "Qualifier",
"text": [
"moderate"
],
"offsets": [
[
27,
35
]
],
"normalized": []
},
{
"id": "NCT03228017_inc_T2",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
39,
45
]
],
"normalized": []
},
{
"id": "NCT03228017_inc_T3",
"type": "Condition",
"text": [
"psoriatic disease"
],
"offsets": [
[
46,
63
]
],
"normalized": []
},
{
"id": "NCT03228017_inc_T4",
"type": "Scope",
"text": [
"moderate to severe"
],
"offsets": [
[
27,
45
]
],
"normalized": []
},
{
"id": "NCT03228017_inc_T5",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
16,
23
]
],
"normalized": []
},
{
"id": "NCT03228017_inc_T6",
"type": "Condition",
"text": [
"Healthy"
],
"offsets": [
[
73,
80
]
],
"normalized": []
},
{
"id": "NCT03228017_inc_T7",
"type": "Condition",
"text": [
"psoriatic disease"
],
"offsets": [
[
104,
121
]
],
"normalized": []
},
{
"id": "NCT03228017_inc_T8",
"type": "Condition",
"text": [
"cardiovascular disease"
],
"offsets": [
[
125,
147
]
],
"normalized": []
},
{
"id": "NCT03228017_inc_T9",
"type": "Negation",
"text": [
"without"
],
"offsets": [
[
90,
97
]
],
"normalized": []
},
{
"id": "NCT03228017_inc_T10",
"type": "Scope",
"text": [
"psoriatic disease or cardiovascular disease"
],
"offsets": [
[
104,
147
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03228017_inc_R1",
"type": "Has_scope",
"arg1_id": "NCT03228017_inc_T3",
"arg2_id": "NCT03228017_inc_T4",
"normalized": []
},
{
"id": "NCT03228017_inc_R2",
"type": "Has_temporal",
"arg1_id": "NCT03228017_inc_T3",
"arg2_id": "NCT03228017_inc_T5",
"normalized": []
},
{
"id": "NCT03228017_inc_R3",
"type": "Has_negation",
"arg1_id": "NCT03228017_inc_T10",
"arg2_id": "NCT03228017_inc_T9",
"normalized": []
}
] |
NCT03228238_exc | NCT03228238 | [
{
"id": "NCT03228238_exc_text",
"type": "exclusion",
"text": [
"NA\n\n"
],
"offsets": [
[
0,
4
]
]
}
] | [] | [] | [] | [] |
NCT03228238_inc | NCT03228238 | [
{
"id": "NCT03228238_inc_text",
"type": "inclusion",
"text": [
"Subject must be at least 30 years of age.\nSubject is able to verbally confirm understandings of risks, benefits and treatment alternatives of receiving the Vitamin C+E or Statin or Dual, and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure.\nSubject must have symptoms that are consistent with vasospastic angina with planned Coronary angiography and Provocation test.\n"
],
"offsets": [
[
0,
442
]
]
}
] | [
{
"id": "NCT03228238_inc_T1",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
37,
40
]
],
"normalized": []
},
{
"id": "NCT03228238_inc_T2",
"type": "Value",
"text": [
"at least 30 years"
],
"offsets": [
[
16,
33
]
],
"normalized": []
},
{
"id": "NCT03228238_inc_T4",
"type": "Condition",
"text": [
"symptoms"
],
"offsets": [
[
333,
341
]
],
"normalized": []
},
{
"id": "NCT03228238_inc_T5",
"type": "Condition",
"text": [
"vasospastic angina"
],
"offsets": [
[
367,
385
]
],
"normalized": []
},
{
"id": "NCT03228238_inc_T6",
"type": "Mood",
"text": [
"planned"
],
"offsets": [
[
391,
398
]
],
"normalized": []
},
{
"id": "NCT03228238_inc_T7",
"type": "Procedure",
"text": [
"Coronary angiography"
],
"offsets": [
[
399,
419
]
],
"normalized": []
},
{
"id": "NCT03228238_inc_T8",
"type": "Procedure",
"text": [
"Provocation test"
],
"offsets": [
[
424,
440
]
],
"normalized": []
},
{
"id": "NCT03228238_inc_T9",
"type": "Scope",
"text": [
"Coronary angiography and Provocation test"
],
"offsets": [
[
399,
440
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03228238_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03228238_inc_T1",
"arg2_id": "NCT03228238_inc_T2",
"normalized": []
},
{
"id": "NCT03228238_inc_R2",
"type": "Has_mood",
"arg1_id": "NCT03228238_inc_T9",
"arg2_id": "NCT03228238_inc_T6",
"normalized": []
},
{
"id": "NCT03228238_inc_R3",
"type": "Has_scope",
"arg1_id": "NCT03228238_inc_T5",
"arg2_id": "NCT03228238_inc_T9",
"normalized": []
},
{
"id": "NCT03228238_inc_R4",
"type": "AND",
"arg1_id": "NCT03228238_inc_T5",
"arg2_id": "NCT03228238_inc_T4",
"normalized": []
}
] |
NCT03228498_exc | NCT03228498 | [
{
"id": "NCT03228498_exc_text",
"type": "exclusion",
"text": [
"1. Absence of objectionable cognitive impairment or presence of dementia of severe degree defined by CDR score > 2.0. \n2. Unavailability of brain MRI (in case of absolute contraindications, the use of cranial CT is allowed). \n3. Expected poor compliance with the study protocol. \n4. Past diagnosis of major depression, schizophrenia, major anxiety syndrome, or manic- depressive illness. \n5. Diagnosis of degenerative cognitive impairment based on clinical and/or neuroradiological findings (i.e., patients with prevailing memory impairment, or with medial temporal atrophy on brain MRI in absence of evident vascular abnormalities; i.e., Alzheimer disease as defined using the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association criteria, Parkinson disease, Huntington disease, frontotemporal dementia). \n6. Diagnosis of cognitive impairment from other causes (i.e., vitamine B12 and folic acid deficiency, thyroid disorders, metabolic diseases, head trauma, tumor or infections of the central nervous system, normal pressure hydrocephalus). \n7. Medical conditions expected to progress, recur, or change to such a degree to interfere with the assessment of the clinical and mental status. \n8. Clinically relevant cardiac or pulmonary insufficiency. \n9. Relevant electrocardiograph abnormalities; bradycardia (50 bpm) or tachycardia (120 bpm) under resting conditions. \n10. Myocardial infarction within the past 6 months. \n11. Stroke still requiring neurological rehabilitation. \n12. Severe/untreated blood pressure (systolic 180 mm Hg, diastolic 95 mm Hg). \n13. Clinically relevant liver function impairment. \n14. Insulin-dependent diabetes mellitus. \n15. Idiopathic epilepsy and anti-epileptic treatment. \n16. Severe anemia (Hb <10 mg/dL). \n17. Severe gastrointestinal disease. \n18. Cancer. \n19. Known intolerance to study drugs. \n20. Coexistent serious illnesses that would imply a drop-out before the end of the trial. \n \n"
],
"offsets": [
[
0,
2011
]
]
}
] | [
{
"id": "NCT03228498_exc_T22",
"type": "Condition",
"text": [
"cognitive impairment"
],
"offsets": [
[
28,
48
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T23",
"type": "Qualifier",
"text": [
"objectionable"
],
"offsets": [
[
14,
27
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T24",
"type": "Negation",
"text": [
"Absence"
],
"offsets": [
[
3,
10
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T25",
"type": "Condition",
"text": [
"dementia"
],
"offsets": [
[
64,
72
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T26",
"type": "Qualifier",
"text": [
"severe degree"
],
"offsets": [
[
76,
89
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T27",
"type": "Measurement",
"text": [
"CDR score"
],
"offsets": [
[
101,
110
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T28",
"type": "Value",
"text": [
"> 2.0"
],
"offsets": [
[
111,
116
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T29",
"type": "Scope",
"text": [
"objectionable cognitive impairment or presence of dementia of severe degree defined by CDR score > 2.0"
],
"offsets": [
[
14,
116
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T30",
"type": "Procedure",
"text": [
"brain MRI"
],
"offsets": [
[
140,
149
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T31",
"type": "Negation",
"text": [
"Unavailability"
],
"offsets": [
[
122,
136
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T32",
"type": "Observation",
"text": [
"Unavailability"
],
"offsets": [
[
122,
136
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T34",
"type": "Procedure",
"text": [
"cranial CT"
],
"offsets": [
[
201,
211
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T35",
"type": "Condition",
"text": [
"absolute contraindications"
],
"offsets": [
[
162,
188
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T38",
"type": "Condition",
"text": [
"major depression"
],
"offsets": [
[
301,
317
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T39",
"type": "Condition",
"text": [
"schizophrenia"
],
"offsets": [
[
319,
332
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T40",
"type": "Condition",
"text": [
"major anxiety syndrome"
],
"offsets": [
[
334,
356
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T41",
"type": "Condition",
"text": [
"manic- depressive illness"
],
"offsets": [
[
361,
386
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T42",
"type": "Observation",
"text": [
"Past diagnosis"
],
"offsets": [
[
283,
297
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T43",
"type": "Scope",
"text": [
"major depression, schizophrenia, major anxiety syndrome, or manic- depressive illness"
],
"offsets": [
[
301,
386
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T44",
"type": "Condition",
"text": [
"degenerative cognitive impairment"
],
"offsets": [
[
405,
438
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T46",
"type": "Condition",
"text": [
"clinical and/or neuroradiological findings"
],
"offsets": [
[
448,
490
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T48",
"type": "Condition",
"text": [
"memory impairment"
],
"offsets": [
[
523,
540
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T49",
"type": "Condition",
"text": [
"medial temporal atrophy"
],
"offsets": [
[
550,
573
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T50",
"type": "Procedure",
"text": [
"brain MRI"
],
"offsets": [
[
577,
586
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T51",
"type": "Negation",
"text": [
"absence"
],
"offsets": [
[
590,
597
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T52",
"type": "Condition",
"text": [
"vascular abnormalities"
],
"offsets": [
[
609,
631
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T54",
"type": "Condition",
"text": [
"Alzheimer disease"
],
"offsets": [
[
639,
656
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T55",
"type": "Measurement",
"text": [
"National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association criteria"
],
"offsets": [
[
678,
814
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T56",
"type": "Condition",
"text": [
"Parkinson disease"
],
"offsets": [
[
816,
833
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T57",
"type": "Condition",
"text": [
"Huntington disease"
],
"offsets": [
[
835,
853
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T58",
"type": "Condition",
"text": [
"frontotemporal dementia"
],
"offsets": [
[
855,
878
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T59",
"type": "Scope",
"text": [
"memory impairment, or with medial temporal atrophy on brain MRI"
],
"offsets": [
[
523,
586
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T60",
"type": "Scope",
"text": [
"memory impairment, or with medial temporal atrophy on brain MRI in absence of evident vascular abnormalities"
],
"offsets": [
[
523,
631
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T61",
"type": "Scope",
"text": [
"Alzheimer disease as defined using the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association criteria, Parkinson disease, Huntington disease, frontotemporal dementia"
],
"offsets": [
[
639,
878
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T62",
"type": "Scope",
"text": [
"memory impairment, or with medial temporal atrophy on brain MRI in absence of evident vascular abnormalities; i.e., Alzheimer disease as defined using the National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association criteria, Parkinson disease, Huntington disease, frontotemporal dementia"
],
"offsets": [
[
523,
878
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T63",
"type": "Condition",
"text": [
"cognitive impairment"
],
"offsets": [
[
898,
918
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T64",
"type": "Qualifier",
"text": [
"other causes"
],
"offsets": [
[
924,
936
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T65",
"type": "Condition",
"text": [
"vitamine B12",
"deficiency"
],
"offsets": [
[
944,
956
],
[
972,
982
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T66",
"type": "Condition",
"text": [
"folic acid deficiency"
],
"offsets": [
[
961,
982
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T67",
"type": "Condition",
"text": [
"thyroid disorders"
],
"offsets": [
[
984,
1001
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T68",
"type": "Condition",
"text": [
"metabolic diseases"
],
"offsets": [
[
1003,
1021
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T69",
"type": "Condition",
"text": [
"head trauma"
],
"offsets": [
[
1023,
1034
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T70",
"type": "Condition",
"text": [
"tumor",
"of the central nervous system"
],
"offsets": [
[
1036,
1041
],
[
1056,
1085
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T71",
"type": "Condition",
"text": [
"infections of the central nervous system"
],
"offsets": [
[
1045,
1085
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T72",
"type": "Condition",
"text": [
"normal pressure hydrocephalus"
],
"offsets": [
[
1087,
1116
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T73",
"type": "Scope",
"text": [
"vitamine B12 and folic acid deficiency, thyroid disorders, metabolic diseases, head trauma, tumor or infections of the central nervous system, normal pressure hydrocephalus"
],
"offsets": [
[
944,
1116
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T78",
"type": "Condition",
"text": [
"cardiac",
"insufficiency"
],
"offsets": [
[
1290,
1297
],
[
1311,
1324
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T79",
"type": "Condition",
"text": [
"pulmonary insufficiency"
],
"offsets": [
[
1301,
1324
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T80",
"type": "Qualifier",
"text": [
"Clinically relevant"
],
"offsets": [
[
1270,
1289
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T81",
"type": "Scope",
"text": [
"cardiac or pulmonary insufficiency"
],
"offsets": [
[
1290,
1324
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T82",
"type": "Condition",
"text": [
"abnormalities"
],
"offsets": [
[
1358,
1371
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T83",
"type": "Procedure",
"text": [
"electrocardiograph"
],
"offsets": [
[
1339,
1357
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T84",
"type": "Condition",
"text": [
"bradycardia"
],
"offsets": [
[
1373,
1384
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T85",
"type": "Measurement",
"text": [
"50 bpm"
],
"offsets": [
[
1386,
1392
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T86",
"type": "Condition",
"text": [
"tachycardia"
],
"offsets": [
[
1397,
1408
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T87",
"type": "Measurement",
"text": [
"120 bpm"
],
"offsets": [
[
1410,
1417
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T88",
"type": "Qualifier",
"text": [
"under resting conditions"
],
"offsets": [
[
1419,
1443
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T89",
"type": "Scope",
"text": [
"bradycardia (50 bpm) or tachycardia (120 bpm)"
],
"offsets": [
[
1373,
1418
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T90",
"type": "Scope",
"text": [
"bradycardia (50 bpm) or tachycardia (120 bpm) under resting conditions"
],
"offsets": [
[
1373,
1443
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T91",
"type": "Qualifier",
"text": [
"Relevant"
],
"offsets": [
[
1330,
1338
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T93",
"type": "Condition",
"text": [
"Myocardial infarction"
],
"offsets": [
[
1450,
1471
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T94",
"type": "Temporal",
"text": [
"within the past 6 months"
],
"offsets": [
[
1472,
1496
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T95",
"type": "Procedure",
"text": [
"neurological rehabilitation"
],
"offsets": [
[
1526,
1553
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T96",
"type": "Condition",
"text": [
"Stroke"
],
"offsets": [
[
1503,
1509
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T99",
"type": "Qualifier",
"text": [
"requiring"
],
"offsets": [
[
1516,
1525
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T101",
"type": "Measurement",
"text": [
"systolic"
],
"offsets": [
[
1593,
1601
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T102",
"type": "Measurement",
"text": [
"diastolic"
],
"offsets": [
[
1613,
1622
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T103",
"type": "Value",
"text": [
"180 mm Hg"
],
"offsets": [
[
1602,
1611
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T104",
"type": "Value",
"text": [
"95 mm Hg"
],
"offsets": [
[
1623,
1631
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T105",
"type": "Scope",
"text": [
"systolic 180 mm Hg, diastolic 95 mm Hg"
],
"offsets": [
[
1593,
1631
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T106",
"type": "Measurement",
"text": [
"blood pressure"
],
"offsets": [
[
1577,
1591
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T107",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
1560,
1566
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T108",
"type": "Qualifier",
"text": [
"untreated"
],
"offsets": [
[
1567,
1576
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T109",
"type": "Scope",
"text": [
"Severe/untreated"
],
"offsets": [
[
1560,
1576
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T110",
"type": "Condition",
"text": [
"liver function impairment"
],
"offsets": [
[
1659,
1684
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T113",
"type": "Qualifier",
"text": [
"Clinically relevant"
],
"offsets": [
[
1639,
1658
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T114",
"type": "Condition",
"text": [
"Insulin-dependent diabetes mellitus"
],
"offsets": [
[
1691,
1726
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T115",
"type": "Condition",
"text": [
"Idiopathic epilepsy"
],
"offsets": [
[
1733,
1752
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T116",
"type": "Condition",
"text": [
"anti-epileptic treatment"
],
"offsets": [
[
1757,
1781
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T117",
"type": "Condition",
"text": [
"anemia"
],
"offsets": [
[
1795,
1801
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T118",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
1788,
1794
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T119",
"type": "Measurement",
"text": [
"Hb"
],
"offsets": [
[
1803,
1805
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T120",
"type": "Value",
"text": [
"<10 mg/dL"
],
"offsets": [
[
1806,
1815
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T121",
"type": "Condition",
"text": [
"gastrointestinal disease"
],
"offsets": [
[
1830,
1854
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T122",
"type": "Qualifier",
"text": [
"Severe"
],
"offsets": [
[
1823,
1829
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T125",
"type": "Condition",
"text": [
"Cancer"
],
"offsets": [
[
1861,
1867
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T126",
"type": "Condition",
"text": [
"intolerance"
],
"offsets": [
[
1880,
1891
]
],
"normalized": []
},
{
"id": "NCT03228498_exc_T127",
"type": "Drug",
"text": [
"study drugs"
],
"offsets": [
[
1895,
1906
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03228498_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03228498_exc_T22",
"arg2_id": "NCT03228498_exc_T23",
"normalized": []
},
{
"id": "NCT03228498_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03228498_exc_T27",
"arg2_id": "NCT03228498_exc_T28",
"normalized": []
},
{
"id": "NCT03228498_exc_R3",
"type": "AND",
"arg1_id": "NCT03228498_exc_T25",
"arg2_id": "NCT03228498_exc_T27",
"normalized": []
},
{
"id": "NCT03228498_exc_R4",
"type": "Subsumes",
"arg1_id": "NCT03228498_exc_T27",
"arg2_id": "NCT03228498_exc_T26",
"normalized": []
},
{
"id": "NCT03228498_exc_R5",
"type": "Has_negation",
"arg1_id": "NCT03228498_exc_T29",
"arg2_id": "NCT03228498_exc_T24",
"normalized": []
},
{
"id": "NCT03228498_exc_R6",
"type": "Has_negation",
"arg1_id": "NCT03228498_exc_T30",
"arg2_id": "NCT03228498_exc_T31",
"normalized": []
},
{
"id": "NCT03228498_exc_R7",
"type": "AND",
"arg1_id": "NCT03228498_exc_T35",
"arg2_id": "NCT03228498_exc_T34",
"normalized": []
},
{
"id": "NCT03228498_exc_R8",
"type": "Has_scope",
"arg1_id": "NCT03228498_exc_T42",
"arg2_id": "NCT03228498_exc_T43",
"normalized": []
},
{
"id": "NCT03228498_exc_R9",
"type": "AND",
"arg1_id": "NCT03228498_exc_T49",
"arg2_id": "NCT03228498_exc_T50",
"normalized": []
},
{
"id": "NCT03228498_exc_R11",
"type": "Has_negation",
"arg1_id": "NCT03228498_exc_T52",
"arg2_id": "NCT03228498_exc_T51",
"normalized": []
},
{
"id": "NCT03228498_exc_R13",
"type": "AND",
"arg1_id": "NCT03228498_exc_T54",
"arg2_id": "NCT03228498_exc_T55",
"normalized": []
},
{
"id": "NCT03228498_exc_R10",
"type": "AND",
"arg1_id": "NCT03228498_exc_T59",
"arg2_id": "NCT03228498_exc_T52",
"normalized": []
},
{
"id": "NCT03228498_exc_R14",
"type": "Has_scope",
"arg1_id": "NCT03228498_exc_T60",
"arg2_id": "NCT03228498_exc_T61",
"normalized": []
},
{
"id": "NCT03228498_exc_R15",
"type": "AND",
"arg1_id": "NCT03228498_exc_T44",
"arg2_id": "NCT03228498_exc_T46",
"normalized": []
},
{
"id": "NCT03228498_exc_R16",
"type": "Subsumes",
"arg1_id": "NCT03228498_exc_T46",
"arg2_id": "NCT03228498_exc_T62",
"normalized": []
},
{
"id": "NCT03228498_exc_R17",
"type": "Subsumes",
"arg1_id": "NCT03228498_exc_T64",
"arg2_id": "NCT03228498_exc_T73",
"normalized": []
},
{
"id": "NCT03228498_exc_R18",
"type": "Has_qualifier",
"arg1_id": "NCT03228498_exc_T63",
"arg2_id": "NCT03228498_exc_T64",
"normalized": []
},
{
"id": "NCT03228498_exc_R19",
"type": "Has_qualifier",
"arg1_id": "NCT03228498_exc_T81",
"arg2_id": "NCT03228498_exc_T80",
"normalized": []
},
{
"id": "NCT03228498_exc_R20",
"type": "AND",
"arg1_id": "NCT03228498_exc_T83",
"arg2_id": "NCT03228498_exc_T82",
"normalized": []
},
{
"id": "NCT03228498_exc_R21",
"type": "Subsumes",
"arg1_id": "NCT03228498_exc_T84",
"arg2_id": "NCT03228498_exc_T85",
"normalized": []
},
{
"id": "NCT03228498_exc_R22",
"type": "Subsumes",
"arg1_id": "NCT03228498_exc_T86",
"arg2_id": "NCT03228498_exc_T87",
"normalized": []
},
{
"id": "NCT03228498_exc_R23",
"type": "Has_qualifier",
"arg1_id": "NCT03228498_exc_T89",
"arg2_id": "NCT03228498_exc_T88",
"normalized": []
},
{
"id": "NCT03228498_exc_R24",
"type": "Has_scope",
"arg1_id": "NCT03228498_exc_T82",
"arg2_id": "NCT03228498_exc_T90",
"normalized": []
},
{
"id": "NCT03228498_exc_R25",
"type": "Has_qualifier",
"arg1_id": "NCT03228498_exc_T82",
"arg2_id": "NCT03228498_exc_T91",
"normalized": []
},
{
"id": "NCT03228498_exc_R26",
"type": "Has_temporal",
"arg1_id": "NCT03228498_exc_T93",
"arg2_id": "NCT03228498_exc_T94",
"normalized": []
},
{
"id": "NCT03228498_exc_R27",
"type": "Has_qualifier",
"arg1_id": "NCT03228498_exc_T95",
"arg2_id": "NCT03228498_exc_T99",
"normalized": []
},
{
"id": "NCT03228498_exc_R28",
"type": "Has_value",
"arg1_id": "NCT03228498_exc_T101",
"arg2_id": "NCT03228498_exc_T103",
"normalized": []
},
{
"id": "NCT03228498_exc_R29",
"type": "Has_value",
"arg1_id": "NCT03228498_exc_T102",
"arg2_id": "NCT03228498_exc_T104",
"normalized": []
},
{
"id": "NCT03228498_exc_R30",
"type": "Has_scope",
"arg1_id": "NCT03228498_exc_T106",
"arg2_id": "NCT03228498_exc_T109",
"normalized": []
},
{
"id": "NCT03228498_exc_R31",
"type": "Subsumes",
"arg1_id": "NCT03228498_exc_T109",
"arg2_id": "NCT03228498_exc_T105",
"normalized": []
},
{
"id": "NCT03228498_exc_R32",
"type": "Has_qualifier",
"arg1_id": "NCT03228498_exc_T110",
"arg2_id": "NCT03228498_exc_T113",
"normalized": []
},
{
"id": "NCT03228498_exc_R33",
"type": "Has_value",
"arg1_id": "NCT03228498_exc_T119",
"arg2_id": "NCT03228498_exc_T120",
"normalized": []
},
{
"id": "NCT03228498_exc_R34",
"type": "Has_qualifier",
"arg1_id": "NCT03228498_exc_T117",
"arg2_id": "NCT03228498_exc_T118",
"normalized": []
},
{
"id": "NCT03228498_exc_R35",
"type": "Subsumes",
"arg1_id": "NCT03228498_exc_T118",
"arg2_id": "NCT03228498_exc_T119",
"normalized": []
},
{
"id": "NCT03228498_exc_R36",
"type": "Has_qualifier",
"arg1_id": "NCT03228498_exc_T121",
"arg2_id": "NCT03228498_exc_T122",
"normalized": []
},
{
"id": "NCT03228498_exc_R37",
"type": "AND",
"arg1_id": "NCT03228498_exc_T126",
"arg2_id": "NCT03228498_exc_T127",
"normalized": []
}
] |
NCT03228498_inc | NCT03228498 | [
{
"id": "NCT03228498_inc_text",
"type": "inclusion",
"text": [
"1. Cognitive impairment from mild to moderate degree defined by a Clinical Deterioration Rating (CDR) score range between 0.5 and 2.0. \n2. Evidence on brain MRI of white matter hyperintensities (leukoaraiosis of moderate or severe degree according to the modified Fazekas visual scale and/or presence of lacunar infarcts). \n3. Consent to participation in the study. \n"
],
"offsets": [
[
0,
367
]
]
}
] | [
{
"id": "NCT03228498_inc_T1",
"type": "Condition",
"text": [
"Cognitive impairment"
],
"offsets": [
[
3,
23
]
],
"normalized": []
},
{
"id": "NCT03228498_inc_T3",
"type": "Qualifier",
"text": [
"mild to moderate"
],
"offsets": [
[
29,
45
]
],
"normalized": []
},
{
"id": "NCT03228498_inc_T2",
"type": "Measurement",
"text": [
"Clinical Deterioration Rating (CDR) score"
],
"offsets": [
[
66,
107
]
],
"normalized": []
},
{
"id": "NCT03228498_inc_T4",
"type": "Value",
"text": [
"range between 0.5 and 2.0"
],
"offsets": [
[
108,
133
]
],
"normalized": []
},
{
"id": "NCT03228498_inc_T5",
"type": "Procedure",
"text": [
"brain MRI"
],
"offsets": [
[
151,
160
]
],
"normalized": []
},
{
"id": "NCT03228498_inc_T6",
"type": "Observation",
"text": [
"white matter hyperintensities"
],
"offsets": [
[
164,
193
]
],
"normalized": []
},
{
"id": "NCT03228498_inc_T7",
"type": "Condition",
"text": [
"leukoaraiosis"
],
"offsets": [
[
195,
208
]
],
"normalized": []
},
{
"id": "NCT03228498_inc_T8",
"type": "Value",
"text": [
"moderate or severe degree"
],
"offsets": [
[
212,
237
]
],
"normalized": []
},
{
"id": "NCT03228498_inc_T9",
"type": "Measurement",
"text": [
"modified Fazekas visual scale"
],
"offsets": [
[
255,
284
]
],
"normalized": []
},
{
"id": "NCT03228498_inc_T10",
"type": "Condition",
"text": [
"lacunar infarcts"
],
"offsets": [
[
304,
320
]
],
"normalized": []
},
{
"id": "NCT03228498_inc_T11",
"type": "Scope",
"text": [
"leukoaraiosis of moderate or severe degree according to the modified Fazekas visual scale and/or presence of lacunar infarcts"
],
"offsets": [
[
195,
320
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03228498_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03228498_inc_T2",
"arg2_id": "NCT03228498_inc_T4",
"normalized": []
},
{
"id": "NCT03228498_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03228498_inc_T1",
"arg2_id": "NCT03228498_inc_T3",
"normalized": []
},
{
"id": "NCT03228498_inc_R3",
"type": "Has_value",
"arg1_id": "NCT03228498_inc_T9",
"arg2_id": "NCT03228498_inc_T8",
"normalized": []
},
{
"id": "NCT03228498_inc_R4",
"type": "AND",
"arg1_id": "NCT03228498_inc_T7",
"arg2_id": "NCT03228498_inc_T9",
"normalized": []
},
{
"id": "NCT03228498_inc_R6",
"type": "Subsumes",
"arg1_id": "NCT03228498_inc_T6",
"arg2_id": "NCT03228498_inc_T11",
"normalized": []
}
] |
NCT03228654_exc | NCT03228654 | [
{
"id": "NCT03228654_exc_text",
"type": "exclusion",
"text": [
"Suspected or known gynecological malignancy.\nuterine size >12 weeks.\nEndometriosis\nPresence of adnexal mass.\ncervix flushed with the vagina.\npresence of significant scarring in the pelvic area from previous surgery.\n"
],
"offsets": [
[
0,
216
]
]
}
] | [
{
"id": "NCT03228654_exc_T1",
"type": "Condition",
"text": [
"gynecological malignancy"
],
"offsets": [
[
19,
43
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T2",
"type": "Mood",
"text": [
"Suspected"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T3",
"type": "Mood",
"text": [
"known"
],
"offsets": [
[
13,
18
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T4",
"type": "Scope",
"text": [
"Suspected or known"
],
"offsets": [
[
0,
18
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T5",
"type": "Measurement",
"text": [
"uterine size"
],
"offsets": [
[
45,
57
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T6",
"type": "Value",
"text": [
">12 weeks"
],
"offsets": [
[
58,
67
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T7",
"type": "Condition",
"text": [
"Endometriosis"
],
"offsets": [
[
69,
82
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T8",
"type": "Condition",
"text": [
"adnexal mass"
],
"offsets": [
[
95,
107
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T9",
"type": "Condition",
"text": [
"cervix flushed with the vagina"
],
"offsets": [
[
109,
139
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T10",
"type": "Condition",
"text": [
"significant scarring"
],
"offsets": [
[
153,
173
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T11",
"type": "Qualifier",
"text": [
"pelvic area"
],
"offsets": [
[
181,
192
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T12",
"type": "Procedure",
"text": [
"surgery"
],
"offsets": [
[
207,
214
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T13",
"type": "Qualifier",
"text": [
"from previous surgery"
],
"offsets": [
[
193,
214
]
],
"normalized": []
},
{
"id": "NCT03228654_exc_T14",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
198,
206
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03228654_exc_R1",
"type": "Has_scope",
"arg1_id": "NCT03228654_exc_T1",
"arg2_id": "NCT03228654_exc_T4",
"normalized": []
},
{
"id": "NCT03228654_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03228654_exc_T5",
"arg2_id": "NCT03228654_exc_T6",
"normalized": []
},
{
"id": "NCT03228654_exc_R4",
"type": "Has_qualifier",
"arg1_id": "NCT03228654_exc_T10",
"arg2_id": "NCT03228654_exc_T11",
"normalized": []
},
{
"id": "NCT03228654_exc_R5",
"type": "Has_qualifier",
"arg1_id": "NCT03228654_exc_T10",
"arg2_id": "NCT03228654_exc_T13",
"normalized": []
},
{
"id": "NCT03228654_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT03228654_exc_T12",
"arg2_id": "NCT03228654_exc_T14",
"normalized": []
}
] |
NCT03228654_inc | NCT03228654 | [
{
"id": "NCT03228654_inc_text",
"type": "inclusion",
"text": [
"uterine size <12 weeks.\npresence of benign cause for the hysterectomy e.g. fibroid uterus, perimenopausal beeding not responding to medical treatment or complex endometrial hyperplasia without atypia.\nAbsence of significant scarring in the pelvis from previous surgeries.\n"
],
"offsets": [
[
0,
272
]
]
}
] | [
{
"id": "NCT03228654_inc_T1",
"type": "Measurement",
"text": [
"uterine size"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T2",
"type": "Value",
"text": [
"<12 weeks"
],
"offsets": [
[
13,
22
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T3",
"type": "Condition",
"text": [
"benign cause"
],
"offsets": [
[
36,
48
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T4",
"type": "Procedure",
"text": [
"hysterectomy"
],
"offsets": [
[
57,
69
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T5",
"type": "Condition",
"text": [
"fibroid uterus"
],
"offsets": [
[
75,
89
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T6",
"type": "Condition",
"text": [
"perimenopausal beeding"
],
"offsets": [
[
91,
113
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T7",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
114,
117
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T8",
"type": "Qualifier",
"text": [
"responding to medical treatment"
],
"offsets": [
[
118,
149
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T9",
"type": "Procedure",
"text": [
"medical treatment"
],
"offsets": [
[
132,
149
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T10",
"type": "Condition",
"text": [
"complex endometrial hyperplasia"
],
"offsets": [
[
153,
184
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T11",
"type": "Negation",
"text": [
"without"
],
"offsets": [
[
185,
192
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T12",
"type": "Condition",
"text": [
"atypia"
],
"offsets": [
[
193,
199
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T13",
"type": "Scope",
"text": [
"benign cause for the hysterectomy"
],
"offsets": [
[
36,
69
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T14",
"type": "Scope",
"text": [
"fibroid uterus, perimenopausal beeding not responding to medical treatment or complex endometrial hyperplasia without atypia"
],
"offsets": [
[
75,
199
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T15",
"type": "Negation",
"text": [
"Absence"
],
"offsets": [
[
201,
208
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T16",
"type": "Condition",
"text": [
"significant scarring"
],
"offsets": [
[
212,
232
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T17",
"type": "Qualifier",
"text": [
"pelvis"
],
"offsets": [
[
240,
246
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T18",
"type": "Qualifier",
"text": [
"from previous surgeries"
],
"offsets": [
[
247,
270
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T19",
"type": "Temporal",
"text": [
"previous"
],
"offsets": [
[
252,
260
]
],
"normalized": []
},
{
"id": "NCT03228654_inc_T20",
"type": "Procedure",
"text": [
"surgeries"
],
"offsets": [
[
261,
270
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03228654_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03228654_inc_T1",
"arg2_id": "NCT03228654_inc_T2",
"normalized": []
},
{
"id": "NCT03228654_inc_R3",
"type": "Has_negation",
"arg1_id": "NCT03228654_inc_T12",
"arg2_id": "NCT03228654_inc_T11",
"normalized": []
},
{
"id": "NCT03228654_inc_R4",
"type": "AND",
"arg1_id": "NCT03228654_inc_T10",
"arg2_id": "NCT03228654_inc_T12",
"normalized": []
},
{
"id": "NCT03228654_inc_R5",
"type": "AND",
"arg1_id": "NCT03228654_inc_T3",
"arg2_id": "NCT03228654_inc_T4",
"normalized": []
},
{
"id": "NCT03228654_inc_R6",
"type": "Has_qualifier",
"arg1_id": "NCT03228654_inc_T6",
"arg2_id": "NCT03228654_inc_T8",
"normalized": []
},
{
"id": "NCT03228654_inc_R7",
"type": "Has_negation",
"arg1_id": "NCT03228654_inc_T8",
"arg2_id": "NCT03228654_inc_T7",
"normalized": []
},
{
"id": "NCT03228654_inc_R8",
"type": "Subsumes",
"arg1_id": "NCT03228654_inc_T13",
"arg2_id": "NCT03228654_inc_T14",
"normalized": []
},
{
"id": "NCT03228654_inc_R9",
"type": "Has_temporal",
"arg1_id": "NCT03228654_inc_T20",
"arg2_id": "NCT03228654_inc_T19",
"normalized": []
},
{
"id": "NCT03228654_inc_R11",
"type": "Has_qualifier",
"arg1_id": "NCT03228654_inc_T16",
"arg2_id": "NCT03228654_inc_T17",
"normalized": []
},
{
"id": "NCT03228654_inc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT03228654_inc_T16",
"arg2_id": "NCT03228654_inc_T18",
"normalized": []
},
{
"id": "NCT03228654_inc_R13",
"type": "Has_negation",
"arg1_id": "NCT03228654_inc_T16",
"arg2_id": "NCT03228654_inc_T15",
"normalized": []
}
] |
NCT03231982_exc | NCT03231982 | [
{
"id": "NCT03231982_exc_text",
"type": "exclusion",
"text": [
"The difference in blood pressure between the selected arm versus non-selected arm is = 20 mmHg for siSBP and = 10 mmHg for siDBP at Visit 1 (screening).\nBlood pressure taken at screening and randomization is = 180 mmHg for siSBP or = 110 mmHg for siDBP.\nDiagnosed with secondary hypertension or suspected of secondary hypertension [e.g., renovascular disease, adrenal medullary and cortical hyperfunction, coarctation of the aorta, hyperaldosteronism, unilateral or bilateral renal artery stenosis, Cushing's syndrome, pheochromocytoma, polycystic kidney disease, etc.]\nPatients with symptomatic orthostatic hypertension (the difference in the blood pressures between measured at supine position and measured at standing position is = 20 mmHg for siSBP and = 10 mmHg for siDBP)\nDiagnosis of type 1 diabetes mellitus (DM) or uncontrolled DM (patients on insulin therapy or with HbA1c > 9%)\nPatients with severe cardiac conditions: heart failure (NYHA Class 3 or 4), history of ischemic cardiac disease (unstable angina, myocardial infarction), peripheral vascular diseases, percutaneous transluminal angioplasty or coronary artery bypass graft within recent 6 months.\nPatients with clinically significant ventricular tachycardia, atrial fibrillation, atrial flutter or other clinically significant arrhythmia at the discretion of the investigator\nPatients with hypertrophic occlusive myocardiopathy, severe occlusive coronary artery disease, aortic stenosis, hemodynamically significant aortic valve or mitral valve stenosis\nHistory of cardiogenic shock\nPresence of severe cerebrovascular disorders (diagnosis of stroke, cerebral infarction or cerebral hemorrhage within recent 6 months)\nHistory or current evidence of wasting, autoimmune (such as rheumatoid arthritis and systemic lupus erythematosus) or connective tissue diseases\nKnown diagnosis of moderate or malignant retinopathy (including retinal hemorrhage, visual disturbance and retinal microaneurysm within 6 months)\nPatients with surgical or medical intestinal diseases or having received surgeries that could interfere with drug absorption distribution, metabolism and elimination\nHistory of malignancy including leukemia and lymphoma within recent 5 years except for localized basal cell carcinoma of the skin)\nPatients with any inflammatory diseases requiring chronic anti-inflammatory therapy\nRenal failure on dialysis\nAST or ALT >2 x upper limit of normal (ULN)\nSerum creatinine > 1.5 x ULN\nSerum potassium < 3.5 mmol/L or >5.5 mmol/L\nNeeds for co-administration of non-study antihypertensive agents or contraindicated medications during the study\nHistory of hypersensitivity to ARBs or dihydropyridines\nHistory of angioedema to treatment with ACE inhibitors or ARBs\nPregnant or lactating women and female volunteers of childbearing potential (except for women who are surgically sterile) who are not willing to use an adequate method of contraception (oral contraceptives, intrauterine device, condom, etc.) during the study. Women of childbearing potential who are not surgically sterile will be allowed to participate in the study only if they have negative pregnancy test at Visit 1 (screening) and should continue to use medically acceptable method of contraception (basic body temperature method and rhythm method will not be allowed). Women with no menses for = 12 months will be considered as postmenopausal state and method of contraception using hormonal contraception such as oral contraceptive should be initiated from or prior to the screening.\nHistory of drug or alcohol abuse within recent 1 year\nPatients having received any other investigational product within recent 12 weeks\nConditions which render a subject ineligible for the study at the discretion of the investigator\n"
],
"offsets": [
[
0,
3758
]
]
}
] | [
{
"id": "NCT03231982_exc_T1",
"type": "Measurement",
"text": [
"difference in blood pressure"
],
"offsets": [
[
4,
32
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T2",
"type": "Qualifier",
"text": [
"selected arm versus non-selected arm"
],
"offsets": [
[
45,
81
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T3",
"type": "Value",
"text": [
"= 20 mmHg"
],
"offsets": [
[
85,
94
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T4",
"type": "Value",
"text": [
"= 10 mmHg"
],
"offsets": [
[
109,
118
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T5",
"type": "Measurement",
"text": [
"siDBP"
],
"offsets": [
[
123,
128
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T6",
"type": "Measurement",
"text": [
"siSBP"
],
"offsets": [
[
99,
104
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T7",
"type": "Temporal",
"text": [
"at Visit 1"
],
"offsets": [
[
129,
139
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T8",
"type": "Measurement",
"text": [
"Blood pressure"
],
"offsets": [
[
153,
167
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T9",
"type": "Temporal",
"text": [
"at screening"
],
"offsets": [
[
174,
186
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T10",
"type": "Temporal",
"text": [
"t",
"andomization"
],
"offsets": [
[
175,
176
],
[
192,
204
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T11",
"type": "Value",
"text": [
"= 180 mmHg"
],
"offsets": [
[
208,
218
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T12",
"type": "Value",
"text": [
"= 110 mmHg"
],
"offsets": [
[
232,
242
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T13",
"type": "Measurement",
"text": [
"siDBP"
],
"offsets": [
[
247,
252
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T14",
"type": "Measurement",
"text": [
"siSBP"
],
"offsets": [
[
223,
228
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T15",
"type": "Scope",
"text": [
"= 180 mmHg for siSBP or = 110 mmHg for siDBP"
],
"offsets": [
[
208,
252
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T16",
"type": "Condition",
"text": [
"hypertension"
],
"offsets": [
[
279,
291
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T17",
"type": "Qualifier",
"text": [
"secondary"
],
"offsets": [
[
269,
278
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T18",
"type": "Mood",
"text": [
"suspected"
],
"offsets": [
[
295,
304
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T19",
"type": "Qualifier",
"text": [
"secondary"
],
"offsets": [
[
308,
317
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T20",
"type": "Condition",
"text": [
"hypertension"
],
"offsets": [
[
318,
330
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T21",
"type": "Condition",
"text": [
"renovascular disease"
],
"offsets": [
[
338,
358
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T22",
"type": "Condition",
"text": [
"renal medullary a",
"perfunction,"
],
"offsets": [
[
362,
379
],
[
393,
405
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T23",
"type": "Condition",
"text": [
"cortical hyperfunction"
],
"offsets": [
[
382,
404
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T24",
"type": "Condition",
"text": [
"coarctation of the aorta"
],
"offsets": [
[
406,
430
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T25",
"type": "Condition",
"text": [
"hyperaldosteronism"
],
"offsets": [
[
432,
450
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T26",
"type": "Qualifier",
"text": [
"unilateral"
],
"offsets": [
[
452,
462
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T27",
"type": "Qualifier",
"text": [
"bilateral"
],
"offsets": [
[
466,
475
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T28",
"type": "Condition",
"text": [
"renal artery stenosis"
],
"offsets": [
[
476,
497
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T29",
"type": "Scope",
"text": [
"unilateral or bilateral"
],
"offsets": [
[
452,
475
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T30",
"type": "Condition",
"text": [
"Cushing's syndrome"
],
"offsets": [
[
499,
517
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T31",
"type": "Condition",
"text": [
"pheochromocytoma"
],
"offsets": [
[
519,
535
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T32",
"type": "Condition",
"text": [
"polycystic kidney disease"
],
"offsets": [
[
537,
562
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T33",
"type": "Scope",
"text": [
"renovascular disease, adrenal medullary and cortical hyperfunction, coarctation of the aorta, hyperaldosteronism, unilateral or bilateral renal artery stenosis, Cushing's syndrome, pheochromocytoma, polycystic kidney disease"
],
"offsets": [
[
338,
562
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T34",
"type": "Scope",
"text": [
"secondary hypertension or suspected of secondary hypertension"
],
"offsets": [
[
269,
330
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T35",
"type": "Condition",
"text": [
"orthostatic hypertension"
],
"offsets": [
[
596,
620
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T36",
"type": "Qualifier",
"text": [
"symptomatic"
],
"offsets": [
[
584,
595
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T37",
"type": "Measurement",
"text": [
"difference in the blood pressures"
],
"offsets": [
[
626,
659
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T38",
"type": "Qualifier",
"text": [
"measured at supine position and measured at standing position"
],
"offsets": [
[
668,
729
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T39",
"type": "Value",
"text": [
"= 20 mmHg"
],
"offsets": [
[
733,
742
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T40",
"type": "Value",
"text": [
"= 10 mmHg"
],
"offsets": [
[
757,
766
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T41",
"type": "Measurement",
"text": [
"siDBP"
],
"offsets": [
[
771,
776
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T42",
"type": "Measurement",
"text": [
"siSBP"
],
"offsets": [
[
747,
752
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T43",
"type": "Scope",
"text": [
"difference in the blood pressures between measured at supine position and measured at standing position is = 20 mmHg for siSBP and = 10 mmHg for siDBP"
],
"offsets": [
[
626,
776
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T44",
"type": "Scope",
"text": [
"symptomatic orthostatic hypertension"
],
"offsets": [
[
584,
620
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T45",
"type": "Condition",
"text": [
"type 1 diabetes mellitus (DM)"
],
"offsets": [
[
791,
820
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T46",
"type": "Qualifier",
"text": [
"uncontrolled"
],
"offsets": [
[
824,
836
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T47",
"type": "Condition",
"text": [
"DM"
],
"offsets": [
[
837,
839
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T48",
"type": "Procedure",
"text": [
"insulin therapy"
],
"offsets": [
[
853,
868
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T49",
"type": "Measurement",
"text": [
"HbA1c"
],
"offsets": [
[
877,
882
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T50",
"type": "Value",
"text": [
"> 9%"
],
"offsets": [
[
883,
887
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T51",
"type": "Scope",
"text": [
"insulin therapy or with HbA1c > 9%"
],
"offsets": [
[
853,
887
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T52",
"type": "Scope",
"text": [
"type 1 diabetes mellitus (DM) or uncontrolled DM"
],
"offsets": [
[
791,
839
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T53",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
903,
909
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T54",
"type": "Condition",
"text": [
"cardiac conditions"
],
"offsets": [
[
910,
928
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T55",
"type": "Condition",
"text": [
"heart failure"
],
"offsets": [
[
930,
943
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T56",
"type": "Measurement",
"text": [
"NYHA"
],
"offsets": [
[
945,
949
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T57",
"type": "Value",
"text": [
"Class 3 or 4"
],
"offsets": [
[
950,
962
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T58",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
965,
972
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T59",
"type": "Condition",
"text": [
"ischemic cardiac disease"
],
"offsets": [
[
976,
1000
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T60",
"type": "Condition",
"text": [
"unstable angina"
],
"offsets": [
[
1002,
1017
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T61",
"type": "Condition",
"text": [
"myocardial infarction"
],
"offsets": [
[
1019,
1040
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T62",
"type": "Condition",
"text": [
"peripheral vascular diseases"
],
"offsets": [
[
1043,
1071
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T63",
"type": "Procedure",
"text": [
"percutaneous transluminal angioplasty"
],
"offsets": [
[
1073,
1110
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T64",
"type": "Procedure",
"text": [
"coronary artery bypass graft"
],
"offsets": [
[
1114,
1142
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T65",
"type": "Temporal",
"text": [
"within recent 6 months"
],
"offsets": [
[
1143,
1165
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T66",
"type": "Scope",
"text": [
"percutaneous transluminal angioplasty or coronary artery bypass graft"
],
"offsets": [
[
1073,
1142
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T67",
"type": "Scope",
"text": [
"unstable angina, myocardial infarction), peripheral vascular diseases, percutaneous transluminal angioplasty or coronary artery bypass graft within recent 6 months"
],
"offsets": [
[
1002,
1165
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T68",
"type": "Scope",
"text": [
"heart failure (NYHA Class 3 or 4), history of ischemic cardiac disease (unstable angina, myocardial infarction), peripheral vascular diseases, percutaneous transluminal angioplasty or coronary artery bypass graft within recent 6 months"
],
"offsets": [
[
930,
1165
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T69",
"type": "Qualifier",
"text": [
"clinically significant"
],
"offsets": [
[
1181,
1203
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T70",
"type": "Condition",
"text": [
"ventricular tachycardia"
],
"offsets": [
[
1204,
1227
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T71",
"type": "Condition",
"text": [
"atrial fibrillation"
],
"offsets": [
[
1229,
1248
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T72",
"type": "Condition",
"text": [
"atrial flutter"
],
"offsets": [
[
1250,
1264
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T73",
"type": "Qualifier",
"text": [
"clinically significant"
],
"offsets": [
[
1274,
1296
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T74",
"type": "Condition",
"text": [
"arrhythmia"
],
"offsets": [
[
1297,
1307
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T75",
"type": "Scope",
"text": [
"ventricular tachycardia, atrial fibrillation, atrial flutter"
],
"offsets": [
[
1204,
1264
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T76",
"type": "Condition",
"text": [
"hypertrophic occlusive myocardiopathy"
],
"offsets": [
[
1360,
1397
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T77",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
1399,
1405
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T78",
"type": "Condition",
"text": [
"occlusive coronary artery disease"
],
"offsets": [
[
1406,
1439
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T79",
"type": "Condition",
"text": [
"aortic stenosis"
],
"offsets": [
[
1441,
1456
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T80",
"type": "Qualifier",
"text": [
"hemodynamically significant"
],
"offsets": [
[
1458,
1485
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T85",
"type": "Condition",
"text": [
"mitral valve stenosis"
],
"offsets": [
[
1502,
1523
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T87",
"type": "Condition",
"text": [
"cardiogenic shock"
],
"offsets": [
[
1535,
1552
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T88",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
1524,
1531
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T82",
"type": "Qualifier",
"text": [
"severe"
],
"offsets": [
[
1565,
1571
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T81",
"type": "Condition",
"text": [
"valve or mit",
"s\nHistor"
],
"offsets": [
[
1493,
1505
],
[
1522,
1530
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T83",
"type": "Scope",
"text": [
"aortic valve or mitral valve stenosis"
],
"offsets": [
[
1486,
1523
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T84",
"type": "Condition",
"text": [
"cerebrovascular disorders"
],
"offsets": [
[
1572,
1597
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T86",
"type": "Condition",
"text": [
"stroke"
],
"offsets": [
[
1612,
1618
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T89",
"type": "Condition",
"text": [
"cerebral infarction"
],
"offsets": [
[
1620,
1639
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T90",
"type": "Condition",
"text": [
"cerebral hemorrhage"
],
"offsets": [
[
1643,
1662
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T91",
"type": "Temporal",
"text": [
"within recent 6 months"
],
"offsets": [
[
1663,
1685
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T92",
"type": "Scope",
"text": [
"stroke, cerebral infarction or cerebral hemorrhage"
],
"offsets": [
[
1612,
1662
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T93",
"type": "Scope",
"text": [
"severe cerebrovascular disorders"
],
"offsets": [
[
1565,
1597
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T94",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
1687,
1694
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T95",
"type": "Temporal",
"text": [
"current"
],
"offsets": [
[
1698,
1705
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T96",
"type": "Observation",
"text": [
"wasting"
],
"offsets": [
[
1718,
1725
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T97",
"type": "Condition",
"text": [
" (such a",
"nown dia"
],
"offsets": [
[
1737,
1745
],
[
1833,
1841
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T98",
"type": "Condition",
"text": [
"rheumatoid arthritis"
],
"offsets": [
[
1747,
1767
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T99",
"type": "Condition",
"text": [
"systemic lupus erythematosus"
],
"offsets": [
[
1772,
1800
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T100",
"type": "Condition",
"text": [
"connective tissue diseases"
],
"offsets": [
[
1805,
1831
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T102",
"type": "Scope",
"text": [
"rheumatoid arthritis and systemic lupus erythematosus"
],
"offsets": [
[
1747,
1800
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T101",
"type": "Scope",
"text": [
"History or current"
],
"offsets": [
[
1687,
1705
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T103",
"type": "Scope",
"text": [
"wasting, autoimmune (such as rheumatoid arthritis and systemic lupus erythematosus) or connective tissue diseases"
],
"offsets": [
[
1718,
1831
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T104",
"type": "Qualifier",
"text": [
"malignant"
],
"offsets": [
[
1863,
1872
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T105",
"type": "Qualifier",
"text": [
"moderate"
],
"offsets": [
[
1851,
1859
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T106",
"type": "Condition",
"text": [
"retinopathy"
],
"offsets": [
[
1873,
1884
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T107",
"type": "Condition",
"text": [
"retinal hemorrhage"
],
"offsets": [
[
1896,
1914
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T108",
"type": "Condition",
"text": [
"visual disturbance"
],
"offsets": [
[
1916,
1934
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T109",
"type": "Condition",
"text": [
"retinal microaneurysm"
],
"offsets": [
[
1939,
1960
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T110",
"type": "Temporal",
"text": [
"within 6 months"
],
"offsets": [
[
1961,
1976
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T111",
"type": "Scope",
"text": [
"moderate or malignant"
],
"offsets": [
[
1851,
1872
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T112",
"type": "Scope",
"text": [
"retinal hemorrhage, visual disturbance and retinal microaneurysm"
],
"offsets": [
[
1896,
1960
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T113",
"type": "Condition",
"text": [
"intestinal diseases"
],
"offsets": [
[
2012,
2031
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T114",
"type": "Qualifier",
"text": [
"surgical"
],
"offsets": [
[
1992,
2000
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T115",
"type": "Qualifier",
"text": [
"medical"
],
"offsets": [
[
2004,
2011
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T116",
"type": "Scope",
"text": [
"surgical or medical"
],
"offsets": [
[
1992,
2011
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T117",
"type": "Procedure",
"text": [
"surgeries"
],
"offsets": [
[
2051,
2060
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T118",
"type": "Qualifier",
"text": [
"could interfere with drug absorption distribution"
],
"offsets": [
[
2066,
2115
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T119",
"type": "Qualifier",
"text": [
"ere with drug absorption",
"nd elimina"
],
"offsets": [
[
2078,
2102
],
[
2129,
2139
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T120",
"type": "Qualifier",
"text": [
"ere with drug absorption",
"History of"
],
"offsets": [
[
2078,
2102
],
[
2144,
2154
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T121",
"type": "Scope",
"text": [
"could interfere with drug absorption distribution, metabolism and elimination"
],
"offsets": [
[
2066,
2143
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T122",
"type": "Scope",
"text": [
"surgical or medical intestinal diseases or having received surgeries"
],
"offsets": [
[
1992,
2060
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T123",
"type": "Condition",
"text": [
"malignancy"
],
"offsets": [
[
2155,
2165
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T124",
"type": "Observation",
"text": [
"History of"
],
"offsets": [
[
2144,
2154
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T125",
"type": "Condition",
"text": [
"leukemia"
],
"offsets": [
[
2176,
2184
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T126",
"type": "Condition",
"text": [
"lymphoma"
],
"offsets": [
[
2189,
2197
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T127",
"type": "Temporal",
"text": [
"within recent 5 years"
],
"offsets": [
[
2198,
2219
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T128",
"type": "Condition",
"text": [
"localized basal cell carcinoma of the skin"
],
"offsets": [
[
2231,
2273
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T129",
"type": "Negation",
"text": [
"except for"
],
"offsets": [
[
2220,
2230
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T130",
"type": "Scope",
"text": [
"leukemia and lymphoma"
],
"offsets": [
[
2176,
2197
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T131",
"type": "Condition",
"text": [
"inflammatory diseases"
],
"offsets": [
[
2293,
2314
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T132",
"type": "Qualifier",
"text": [
"chronic"
],
"offsets": [
[
2325,
2332
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T133",
"type": "Procedure",
"text": [
"anti-inflammatory therapy"
],
"offsets": [
[
2333,
2358
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T134",
"type": "Drug",
"text": [
"anti-inflammatory therapy"
],
"offsets": [
[
2333,
2358
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T135",
"type": "Condition",
"text": [
"Renal failure"
],
"offsets": [
[
2359,
2372
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T136",
"type": "Procedure",
"text": [
"dialysis"
],
"offsets": [
[
2376,
2384
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T137",
"type": "Measurement",
"text": [
"AST"
],
"offsets": [
[
2385,
2388
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T138",
"type": "Measurement",
"text": [
"ALT"
],
"offsets": [
[
2392,
2395
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T139",
"type": "Value",
"text": [
">2 x upper limit of normal (ULN)"
],
"offsets": [
[
2396,
2428
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T140",
"type": "Scope",
"text": [
"AST or ALT"
],
"offsets": [
[
2385,
2395
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T141",
"type": "Measurement",
"text": [
"Serum creatinine"
],
"offsets": [
[
2429,
2445
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T142",
"type": "Value",
"text": [
"> 1.5 x ULN"
],
"offsets": [
[
2446,
2457
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T143",
"type": "Measurement",
"text": [
"Serum potassium"
],
"offsets": [
[
2458,
2473
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T144",
"type": "Value",
"text": [
"< 3.5 mmol/L"
],
"offsets": [
[
2474,
2486
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T145",
"type": "Value",
"text": [
">5.5 mmol/L"
],
"offsets": [
[
2490,
2501
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T146",
"type": "Scope",
"text": [
"< 3.5 mmol/L or >5.5 mmol/L"
],
"offsets": [
[
2474,
2501
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T147",
"type": "Temporal",
"text": [
"f non-study antih",
"story of hyperse"
],
"offsets": [
[
2531,
2548
],
[
2617,
2633
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T148",
"type": "Qualifier",
"text": [
"non-study"
],
"offsets": [
[
2533,
2542
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T149",
"type": "Drug",
"text": [
"antihypertensive agents"
],
"offsets": [
[
2543,
2566
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T150",
"type": "Drug",
"text": [
"contraindicated medications"
],
"offsets": [
[
2570,
2597
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T151",
"type": "Condition",
"text": [
"hypersensitivity"
],
"offsets": [
[
2626,
2642
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T152",
"type": "Drug",
"text": [
"ARBs"
],
"offsets": [
[
2646,
2650
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T153",
"type": "Drug",
"text": [
"dihydropyridines"
],
"offsets": [
[
2654,
2670
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T154",
"type": "Scope",
"text": [
"ARBs or dihydropyridines"
],
"offsets": [
[
2646,
2670
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T155",
"type": "Condition",
"text": [
"angioedema"
],
"offsets": [
[
2682,
2692
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T156",
"type": "Procedure",
"text": [
"treatment"
],
"offsets": [
[
2696,
2705
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T157",
"type": "Drug",
"text": [
"ACE inhibitors"
],
"offsets": [
[
2711,
2725
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T158",
"type": "Drug",
"text": [
"ARBs"
],
"offsets": [
[
2729,
2733
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T159",
"type": "Scope",
"text": [
"ACE inhibitors or ARBs"
],
"offsets": [
[
2711,
2733
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T160",
"type": "Observation",
"text": [
"History of"
],
"offsets": [
[
2671,
2681
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T161",
"type": "Observation",
"text": [
"History of"
],
"offsets": [
[
2615,
2625
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T162",
"type": "Condition",
"text": [
"Pregnant"
],
"offsets": [
[
2734,
2742
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T163",
"type": "Condition",
"text": [
"lactating"
],
"offsets": [
[
2746,
2755
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T164",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
2756,
2761
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T165",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
2766,
2772
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T166",
"type": "Observation",
"text": [
"childbearing potential"
],
"offsets": [
[
2787,
2809
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T167",
"type": "Scope",
"text": [
"Pregnant or lactating women and female volunteers of childbearing potential"
],
"offsets": [
[
2734,
2809
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T168",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
2864,
2867
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T169",
"type": "Mood",
"text": [
"willing to"
],
"offsets": [
[
2868,
2878
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T170",
"type": "Procedure",
"text": [
"adequate method of contraception"
],
"offsets": [
[
2886,
2918
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T172",
"type": "Observation",
"text": [
"History"
],
"offsets": [
[
3525,
3532
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T173",
"type": "Condition",
"text": [
"ithi",
"ear\nP"
],
"offsets": [
[
3559,
3563
],
[
3575,
3580
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T174",
"type": "Condition",
"text": [
"alcohol abuse"
],
"offsets": [
[
3544,
3557
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T175",
"type": "Temporal",
"text": [
"within recent 1 year"
],
"offsets": [
[
3558,
3578
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T176",
"type": "Scope",
"text": [
"drug or alcohol abuse"
],
"offsets": [
[
3536,
3557
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T177",
"type": "Drug",
"text": [
"other investigational product"
],
"offsets": [
[
3608,
3637
]
],
"normalized": []
},
{
"id": "NCT03231982_exc_T178",
"type": "Temporal",
"text": [
"within recent 12 weeks"
],
"offsets": [
[
3638,
3660
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03231982_exc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T1",
"arg2_id": "NCT03231982_exc_T2",
"normalized": []
},
{
"id": "NCT03231982_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03231982_exc_T6",
"arg2_id": "NCT03231982_exc_T3",
"normalized": []
},
{
"id": "NCT03231982_exc_R3",
"type": "Has_value",
"arg1_id": "NCT03231982_exc_T5",
"arg2_id": "NCT03231982_exc_T4",
"normalized": []
},
{
"id": "NCT03231982_exc_R4",
"type": "AND",
"arg1_id": "NCT03231982_exc_T1",
"arg2_id": "NCT03231982_exc_T6",
"normalized": []
},
{
"id": "NCT03231982_exc_R5",
"type": "AND",
"arg1_id": "NCT03231982_exc_T1",
"arg2_id": "NCT03231982_exc_T5",
"normalized": []
},
{
"id": "NCT03231982_exc_R6",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T1",
"arg2_id": "NCT03231982_exc_T7",
"normalized": []
},
{
"id": "NCT03231982_exc_R7",
"type": "Has_value",
"arg1_id": "NCT03231982_exc_T14",
"arg2_id": "NCT03231982_exc_T11",
"normalized": []
},
{
"id": "NCT03231982_exc_R8",
"type": "Has_value",
"arg1_id": "NCT03231982_exc_T13",
"arg2_id": "NCT03231982_exc_T12",
"normalized": []
},
{
"id": "NCT03231982_exc_R9",
"type": "Has_scope",
"arg1_id": "NCT03231982_exc_T8",
"arg2_id": "NCT03231982_exc_T15",
"normalized": []
},
{
"id": "NCT03231982_exc_R10",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T8",
"arg2_id": "NCT03231982_exc_T10",
"normalized": []
},
{
"id": "NCT03231982_exc_R11",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T8",
"arg2_id": "NCT03231982_exc_T9",
"normalized": []
},
{
"id": "NCT03231982_exc_R12",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T16",
"arg2_id": "NCT03231982_exc_T17",
"normalized": []
},
{
"id": "NCT03231982_exc_R13",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T20",
"arg2_id": "NCT03231982_exc_T19",
"normalized": []
},
{
"id": "NCT03231982_exc_R14",
"type": "Has_mood",
"arg1_id": "NCT03231982_exc_T20",
"arg2_id": "NCT03231982_exc_T18",
"normalized": []
},
{
"id": "NCT03231982_exc_R15",
"type": "Has_scope",
"arg1_id": "NCT03231982_exc_T28",
"arg2_id": "NCT03231982_exc_T29",
"normalized": []
},
{
"id": "NCT03231982_exc_R16",
"type": "Subsumes",
"arg1_id": "NCT03231982_exc_T34",
"arg2_id": "NCT03231982_exc_T33",
"normalized": []
},
{
"id": "NCT03231982_exc_R17",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T35",
"arg2_id": "NCT03231982_exc_T36",
"normalized": []
},
{
"id": "NCT03231982_exc_R18",
"type": "Has_value",
"arg1_id": "NCT03231982_exc_T42",
"arg2_id": "NCT03231982_exc_T39",
"normalized": []
},
{
"id": "NCT03231982_exc_R19",
"type": "Has_value",
"arg1_id": "NCT03231982_exc_T41",
"arg2_id": "NCT03231982_exc_T40",
"normalized": []
},
{
"id": "NCT03231982_exc_R20",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T37",
"arg2_id": "NCT03231982_exc_T38",
"normalized": []
},
{
"id": "NCT03231982_exc_R21",
"type": "AND",
"arg1_id": "NCT03231982_exc_T37",
"arg2_id": "NCT03231982_exc_T42",
"normalized": []
},
{
"id": "NCT03231982_exc_R22",
"type": "AND",
"arg1_id": "NCT03231982_exc_T37",
"arg2_id": "NCT03231982_exc_T41",
"normalized": []
},
{
"id": "NCT03231982_exc_R23",
"type": "Subsumes",
"arg1_id": "NCT03231982_exc_T44",
"arg2_id": "NCT03231982_exc_T43",
"normalized": []
},
{
"id": "NCT03231982_exc_R24",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T47",
"arg2_id": "NCT03231982_exc_T46",
"normalized": []
},
{
"id": "NCT03231982_exc_R25",
"type": "Has_value",
"arg1_id": "NCT03231982_exc_T49",
"arg2_id": "NCT03231982_exc_T50",
"normalized": []
},
{
"id": "NCT03231982_exc_R26",
"type": "Subsumes",
"arg1_id": "NCT03231982_exc_T52",
"arg2_id": "NCT03231982_exc_T51",
"normalized": []
},
{
"id": "NCT03231982_exc_R27",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T54",
"arg2_id": "NCT03231982_exc_T53",
"normalized": []
},
{
"id": "NCT03231982_exc_R28",
"type": "Has_value",
"arg1_id": "NCT03231982_exc_T56",
"arg2_id": "NCT03231982_exc_T57",
"normalized": []
},
{
"id": "NCT03231982_exc_R29",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T59",
"arg2_id": "NCT03231982_exc_T58",
"normalized": []
},
{
"id": "NCT03231982_exc_R30",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T66",
"arg2_id": "NCT03231982_exc_T65",
"normalized": []
},
{
"id": "NCT03231982_exc_R31",
"type": "Subsumes",
"arg1_id": "NCT03231982_exc_T59",
"arg2_id": "NCT03231982_exc_T66",
"normalized": []
},
{
"id": "NCT03231982_exc_R32",
"type": "AND",
"arg1_id": "NCT03231982_exc_T55",
"arg2_id": "NCT03231982_exc_T56",
"normalized": []
},
{
"id": "NCT03231982_exc_R33",
"type": "Subsumes",
"arg1_id": "NCT03231982_exc_T54",
"arg2_id": "NCT03231982_exc_T68",
"normalized": []
},
{
"id": "NCT03231982_exc_R34",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T74",
"arg2_id": "NCT03231982_exc_T73",
"normalized": []
},
{
"id": "NCT03231982_exc_R35",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T75",
"arg2_id": "NCT03231982_exc_T69",
"normalized": []
},
{
"id": "NCT03231982_exc_R36",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T78",
"arg2_id": "NCT03231982_exc_T77",
"normalized": []
},
{
"id": "NCT03231982_exc_R37",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T83",
"arg2_id": "NCT03231982_exc_T80",
"normalized": []
},
{
"id": "NCT03231982_exc_R38",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T87",
"arg2_id": "NCT03231982_exc_T88",
"normalized": []
},
{
"id": "NCT03231982_exc_R39",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T84",
"arg2_id": "NCT03231982_exc_T82",
"normalized": []
},
{
"id": "NCT03231982_exc_R40",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T92",
"arg2_id": "NCT03231982_exc_T91",
"normalized": []
},
{
"id": "NCT03231982_exc_R41",
"type": "Subsumes",
"arg1_id": "NCT03231982_exc_T93",
"arg2_id": "NCT03231982_exc_T92",
"normalized": []
},
{
"id": "NCT03231982_exc_R42",
"type": "Subsumes",
"arg1_id": "NCT03231982_exc_T97",
"arg2_id": "NCT03231982_exc_T102",
"normalized": []
},
{
"id": "NCT03231982_exc_R43",
"type": "Subsumes",
"arg1_id": "NCT03231982_exc_T103",
"arg2_id": "NCT03231982_exc_T101",
"normalized": []
},
{
"id": "NCT03231982_exc_R44",
"type": "Has_scope",
"arg1_id": "NCT03231982_exc_T106",
"arg2_id": "NCT03231982_exc_T111",
"normalized": []
},
{
"id": "NCT03231982_exc_R45",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T112",
"arg2_id": "NCT03231982_exc_T110",
"normalized": []
},
{
"id": "NCT03231982_exc_R46",
"type": "Subsumes",
"arg1_id": "NCT03231982_exc_T106",
"arg2_id": "NCT03231982_exc_T112",
"normalized": []
},
{
"id": "NCT03231982_exc_R47",
"type": "Has_scope",
"arg1_id": "NCT03231982_exc_T113",
"arg2_id": "NCT03231982_exc_T116",
"normalized": []
},
{
"id": "NCT03231982_exc_R48",
"type": "Has_scope",
"arg1_id": "NCT03231982_exc_T122",
"arg2_id": "NCT03231982_exc_T121",
"normalized": []
},
{
"id": "NCT03231982_exc_R49",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T123",
"arg2_id": "NCT03231982_exc_T124",
"normalized": []
},
{
"id": "NCT03231982_exc_R50",
"type": "Has_negation",
"arg1_id": "NCT03231982_exc_T128",
"arg2_id": "NCT03231982_exc_T129",
"normalized": []
},
{
"id": "NCT03231982_exc_R51",
"type": "Subsumes",
"arg1_id": "NCT03231982_exc_T123",
"arg2_id": "NCT03231982_exc_T130",
"normalized": []
},
{
"id": "NCT03231982_exc_R52",
"type": "AND",
"arg1_id": "NCT03231982_exc_T123",
"arg2_id": "NCT03231982_exc_T128",
"normalized": []
},
{
"id": "NCT03231982_exc_R53",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T123",
"arg2_id": "NCT03231982_exc_T127",
"normalized": []
},
{
"id": "NCT03231982_exc_R55",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T133",
"arg2_id": "NCT03231982_exc_T132",
"normalized": []
},
{
"id": "NCT03231982_exc_R56",
"type": "AND",
"arg1_id": "NCT03231982_exc_T131",
"arg2_id": "NCT03231982_exc_T133",
"normalized": []
},
{
"id": "NCT03231982_exc_R57",
"type": "AND",
"arg1_id": "NCT03231982_exc_T135",
"arg2_id": "NCT03231982_exc_T136",
"normalized": []
},
{
"id": "NCT03231982_exc_R58",
"type": "Has_value",
"arg1_id": "NCT03231982_exc_T140",
"arg2_id": "NCT03231982_exc_T139",
"normalized": []
},
{
"id": "NCT03231982_exc_R59",
"type": "Has_value",
"arg1_id": "NCT03231982_exc_T141",
"arg2_id": "NCT03231982_exc_T142",
"normalized": []
},
{
"id": "NCT03231982_exc_R60",
"type": "Has_scope",
"arg1_id": "NCT03231982_exc_T143",
"arg2_id": "NCT03231982_exc_T146",
"normalized": []
},
{
"id": "NCT03231982_exc_R61",
"type": "Has_qualifier",
"arg1_id": "NCT03231982_exc_T149",
"arg2_id": "NCT03231982_exc_T148",
"normalized": []
},
{
"id": "NCT03231982_exc_R62",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T149",
"arg2_id": "NCT03231982_exc_T147",
"normalized": []
},
{
"id": "NCT03231982_exc_R63",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T150",
"arg2_id": "NCT03231982_exc_T147",
"normalized": []
},
{
"id": "NCT03231982_exc_R64",
"type": "Has_scope",
"arg1_id": "NCT03231982_exc_T151",
"arg2_id": "NCT03231982_exc_T154",
"normalized": []
},
{
"id": "NCT03231982_exc_R65",
"type": "Has_scope",
"arg1_id": "NCT03231982_exc_T156",
"arg2_id": "NCT03231982_exc_T159",
"normalized": []
},
{
"id": "NCT03231982_exc_R66",
"type": "AND",
"arg1_id": "NCT03231982_exc_T155",
"arg2_id": "NCT03231982_exc_T156",
"normalized": []
},
{
"id": "NCT03231982_exc_R67",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T155",
"arg2_id": "NCT03231982_exc_T160",
"normalized": []
},
{
"id": "NCT03231982_exc_R68",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T151",
"arg2_id": "NCT03231982_exc_T161",
"normalized": []
},
{
"id": "NCT03231982_exc_R69",
"type": "Has_negation",
"arg1_id": "NCT03231982_exc_T169",
"arg2_id": "NCT03231982_exc_T168",
"normalized": []
},
{
"id": "NCT03231982_exc_R70",
"type": "Has_mood",
"arg1_id": "NCT03231982_exc_T170",
"arg2_id": "NCT03231982_exc_T169",
"normalized": []
},
{
"id": "NCT03231982_exc_R71",
"type": "AND",
"arg1_id": "NCT03231982_exc_T167",
"arg2_id": "NCT03231982_exc_T170",
"normalized": []
},
{
"id": "NCT03231982_exc_R72",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T176",
"arg2_id": "NCT03231982_exc_T175",
"normalized": []
},
{
"id": "NCT03231982_exc_R73",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T176",
"arg2_id": "NCT03231982_exc_T172",
"normalized": []
},
{
"id": "NCT03231982_exc_R74",
"type": "Has_temporal",
"arg1_id": "NCT03231982_exc_T177",
"arg2_id": "NCT03231982_exc_T178",
"normalized": []
}
] |
NCT03231982_inc | NCT03231982 | [
{
"id": "NCT03231982_inc_text",
"type": "inclusion",
"text": [
"Adult male and female aged 19 to 75 years\nVoluntarily consented to participate in the study and signed the informed consent form after receiving the explanation of the objectives, methods and effects of the study.\n"
],
"offsets": [
[
0,
214
]
]
}
] | [
{
"id": "NCT03231982_inc_T1",
"type": "Person",
"text": [
"male"
],
"offsets": [
[
6,
10
]
],
"normalized": []
},
{
"id": "NCT03231982_inc_T2",
"type": "Person",
"text": [
"female"
],
"offsets": [
[
15,
21
]
],
"normalized": []
},
{
"id": "NCT03231982_inc_T3",
"type": "Person",
"text": [
"aged"
],
"offsets": [
[
22,
26
]
],
"normalized": []
},
{
"id": "NCT03231982_inc_T4",
"type": "Value",
"text": [
"19 to 75 years"
],
"offsets": [
[
27,
41
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03231982_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03231982_inc_T3",
"arg2_id": "NCT03231982_inc_T4",
"normalized": []
}
] |
NCT03233880_exc | NCT03233880 | [
{
"id": "NCT03233880_exc_text",
"type": "exclusion",
"text": [
"Women with multi-fetal pregnancy, diabetes mellitus, chronic hypertension, or chronic renal disease\n"
],
"offsets": [
[
0,
100
]
]
}
] | [
{
"id": "NCT03233880_exc_T1",
"type": "Person",
"text": [
"Women"
],
"offsets": [
[
0,
5
]
],
"normalized": []
},
{
"id": "NCT03233880_exc_T2",
"type": "Condition",
"text": [
"multi-fetal pregnancy"
],
"offsets": [
[
11,
32
]
],
"normalized": []
},
{
"id": "NCT03233880_exc_T3",
"type": "Condition",
"text": [
"diabetes mellitus"
],
"offsets": [
[
34,
51
]
],
"normalized": []
},
{
"id": "NCT03233880_exc_T4",
"type": "Condition",
"text": [
"chronic hypertension"
],
"offsets": [
[
53,
73
]
],
"normalized": []
},
{
"id": "NCT03233880_exc_T5",
"type": "Condition",
"text": [
"chronic renal disease"
],
"offsets": [
[
78,
99
]
],
"normalized": []
}
] | [] | [] | [] |
NCT03233880_inc | NCT03233880 | [
{
"id": "NCT03233880_inc_text",
"type": "inclusion",
"text": [
"primigravida, singleton pregnancy, maternal age 18-35 years, and pregnancy duration 16-20 weeks at the time of study inclusion.\n"
],
"offsets": [
[
0,
128
]
]
}
] | [
{
"id": "NCT03233880_inc_T1",
"type": "Condition",
"text": [
"primigravida"
],
"offsets": [
[
0,
12
]
],
"normalized": []
},
{
"id": "NCT03233880_inc_T2",
"type": "Condition",
"text": [
"singleton pregnancy"
],
"offsets": [
[
14,
33
]
],
"normalized": []
},
{
"id": "NCT03233880_inc_T3",
"type": "Person",
"text": [
"maternal age"
],
"offsets": [
[
35,
47
]
],
"normalized": []
},
{
"id": "NCT03233880_inc_T4",
"type": "Value",
"text": [
"18-35 years"
],
"offsets": [
[
48,
59
]
],
"normalized": []
},
{
"id": "NCT03233880_inc_T6",
"type": "Measurement",
"text": [
"pregnancy duration"
],
"offsets": [
[
65,
83
]
],
"normalized": []
},
{
"id": "NCT03233880_inc_T7",
"type": "Value",
"text": [
"16-20 weeks"
],
"offsets": [
[
84,
95
]
],
"normalized": []
},
{
"id": "NCT03233880_inc_T5",
"type": "Temporal",
"text": [
"at the time of study inclusion"
],
"offsets": [
[
96,
126
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03233880_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03233880_inc_T3",
"arg2_id": "NCT03233880_inc_T4",
"normalized": []
},
{
"id": "NCT03233880_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03233880_inc_T6",
"arg2_id": "NCT03233880_inc_T7",
"normalized": []
},
{
"id": "NCT03233880_inc_R3",
"type": "Has_temporal",
"arg1_id": "NCT03233880_inc_T6",
"arg2_id": "NCT03233880_inc_T5",
"normalized": []
}
] |
NCT03234816_exc | NCT03234816 | [
{
"id": "NCT03234816_exc_text",
"type": "exclusion",
"text": [
"Cardiac morbidities\nHypertensive disorders of pregnancy,\nPeripartum bleeding\nBaseline systolic blood pressure (SBP) < 100 mmHg\nBody mass index > 35\n"
],
"offsets": [
[
0,
148
]
]
}
] | [
{
"id": "NCT03234816_exc_T1",
"type": "Condition",
"text": [
"Cardiac morbidities"
],
"offsets": [
[
0,
19
]
],
"normalized": []
},
{
"id": "NCT03234816_exc_T2",
"type": "Condition",
"text": [
"Hypertensive disorders of pregnancy"
],
"offsets": [
[
20,
55
]
],
"normalized": []
},
{
"id": "NCT03234816_exc_T3",
"type": "Condition",
"text": [
"Peripartum bleeding"
],
"offsets": [
[
57,
76
]
],
"normalized": []
},
{
"id": "NCT03234816_exc_T4",
"type": "Temporal",
"text": [
"Baseline"
],
"offsets": [
[
77,
85
]
],
"normalized": []
},
{
"id": "NCT03234816_exc_T5",
"type": "Measurement",
"text": [
"systolic blood pressure"
],
"offsets": [
[
86,
109
]
],
"normalized": []
},
{
"id": "NCT03234816_exc_T6",
"type": "Measurement",
"text": [
"SBP"
],
"offsets": [
[
111,
114
]
],
"normalized": []
},
{
"id": "NCT03234816_exc_T7",
"type": "Value",
"text": [
"< 100 mmHg"
],
"offsets": [
[
116,
126
]
],
"normalized": []
},
{
"id": "NCT03234816_exc_T8",
"type": "Measurement",
"text": [
"Body mass index"
],
"offsets": [
[
127,
142
]
],
"normalized": []
},
{
"id": "NCT03234816_exc_T9",
"type": "Value",
"text": [
"> 35"
],
"offsets": [
[
143,
147
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03234816_exc_R1",
"type": "Subsumes",
"arg1_id": "NCT03234816_exc_T5",
"arg2_id": "NCT03234816_exc_T6",
"normalized": []
},
{
"id": "NCT03234816_exc_R2",
"type": "Has_value",
"arg1_id": "NCT03234816_exc_T5",
"arg2_id": "NCT03234816_exc_T7",
"normalized": []
},
{
"id": "NCT03234816_exc_R3",
"type": "Has_temporal",
"arg1_id": "NCT03234816_exc_T5",
"arg2_id": "NCT03234816_exc_T4",
"normalized": []
},
{
"id": "NCT03234816_exc_R4",
"type": "Has_value",
"arg1_id": "NCT03234816_exc_T8",
"arg2_id": "NCT03234816_exc_T9",
"normalized": []
}
] |
NCT03234816_inc | NCT03234816 | [
{
"id": "NCT03234816_inc_text",
"type": "inclusion",
"text": [
"full term singleton pregnant women\nScheduled for elective Cesarean Delivery\nAged between 18 and 40 years\n"
],
"offsets": [
[
0,
105
]
]
}
] | [
{
"id": "NCT03234816_inc_T1",
"type": "Qualifier",
"text": [
"singleton"
],
"offsets": [
[
10,
19
]
],
"normalized": []
},
{
"id": "NCT03234816_inc_T2",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
20,
28
]
],
"normalized": []
},
{
"id": "NCT03234816_inc_T3",
"type": "Qualifier",
"text": [
"full term"
],
"offsets": [
[
0,
9
]
],
"normalized": []
},
{
"id": "NCT03234816_inc_T4",
"type": "Person",
"text": [
"women"
],
"offsets": [
[
29,
34
]
],
"normalized": []
},
{
"id": "NCT03234816_inc_T5",
"type": "Mood",
"text": [
"Scheduled for"
],
"offsets": [
[
35,
48
]
],
"normalized": []
},
{
"id": "NCT03234816_inc_T6",
"type": "Qualifier",
"text": [
"elective"
],
"offsets": [
[
49,
57
]
],
"normalized": []
},
{
"id": "NCT03234816_inc_T7",
"type": "Procedure",
"text": [
"Cesarean Delivery"
],
"offsets": [
[
58,
75
]
],
"normalized": []
},
{
"id": "NCT03234816_inc_T8",
"type": "Person",
"text": [
"Aged"
],
"offsets": [
[
76,
80
]
],
"normalized": []
},
{
"id": "NCT03234816_inc_T9",
"type": "Value",
"text": [
"between 18 and 40 years"
],
"offsets": [
[
81,
104
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03234816_inc_R1",
"type": "Has_qualifier",
"arg1_id": "NCT03234816_inc_T2",
"arg2_id": "NCT03234816_inc_T1",
"normalized": []
},
{
"id": "NCT03234816_inc_R2",
"type": "Has_qualifier",
"arg1_id": "NCT03234816_inc_T2",
"arg2_id": "NCT03234816_inc_T3",
"normalized": []
},
{
"id": "NCT03234816_inc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT03234816_inc_T7",
"arg2_id": "NCT03234816_inc_T6",
"normalized": []
},
{
"id": "NCT03234816_inc_R4",
"type": "Has_mood",
"arg1_id": "NCT03234816_inc_T7",
"arg2_id": "NCT03234816_inc_T5",
"normalized": []
},
{
"id": "NCT03234816_inc_R5",
"type": "Has_value",
"arg1_id": "NCT03234816_inc_T8",
"arg2_id": "NCT03234816_inc_T9",
"normalized": []
}
] |
NCT03236246_exc | NCT03236246 | [
{
"id": "NCT03236246_exc_text",
"type": "exclusion",
"text": [
"Serum phosphate <3.0 mg/dL\nIntravenous (IV) iron administered within 4 weeks prior to Screening\nErythropoiesis-stimulating agents (ESA) administered within 4 weeks prior to Screening\nBlood transfusion within 4 weeks prior to Screening\n"
],
"offsets": [
[
0,
235
]
]
}
] | [
{
"id": "NCT03236246_exc_T1",
"type": "Measurement",
"text": [
"Serum phosphate"
],
"offsets": [
[
0,
15
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T2",
"type": "Value",
"text": [
"<3.0 mg/dL"
],
"offsets": [
[
16,
26
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T3",
"type": "Drug",
"text": [
"iron"
],
"offsets": [
[
44,
48
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T4",
"type": "Qualifier",
"text": [
"IV"
],
"offsets": [
[
40,
42
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T5",
"type": "Qualifier",
"text": [
"Intravenous"
],
"offsets": [
[
27,
38
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T6",
"type": "Temporal",
"text": [
"within 4 weeks prior to Screening"
],
"offsets": [
[
62,
95
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T7",
"type": "Reference_point",
"text": [
"Screening"
],
"offsets": [
[
86,
95
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T8",
"type": "Drug",
"text": [
"Erythropoiesis-stimulating agents"
],
"offsets": [
[
96,
129
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T9",
"type": "Drug",
"text": [
"ESA"
],
"offsets": [
[
131,
134
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T10",
"type": "Temporal",
"text": [
"within 4 weeks prior to Screening"
],
"offsets": [
[
149,
182
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T11",
"type": "Reference_point",
"text": [
"Screening"
],
"offsets": [
[
173,
182
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T12",
"type": "Procedure",
"text": [
"Blood transfusion"
],
"offsets": [
[
183,
200
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T13",
"type": "Temporal",
"text": [
"within 4 weeks prior to Screening"
],
"offsets": [
[
201,
234
]
],
"normalized": []
},
{
"id": "NCT03236246_exc_T14",
"type": "Reference_point",
"text": [
"Screening"
],
"offsets": [
[
225,
234
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03236246_exc_R1",
"type": "Has_value",
"arg1_id": "NCT03236246_exc_T1",
"arg2_id": "NCT03236246_exc_T2",
"normalized": []
},
{
"id": "NCT03236246_exc_R2",
"type": "Subsumes",
"arg1_id": "NCT03236246_exc_T5",
"arg2_id": "NCT03236246_exc_T4",
"normalized": []
},
{
"id": "NCT03236246_exc_R3",
"type": "Has_qualifier",
"arg1_id": "NCT03236246_exc_T3",
"arg2_id": "NCT03236246_exc_T5",
"normalized": []
},
{
"id": "NCT03236246_exc_R4",
"type": "Has_index",
"arg1_id": "NCT03236246_exc_T6",
"arg2_id": "NCT03236246_exc_T7",
"normalized": []
},
{
"id": "NCT03236246_exc_R5",
"type": "Has_temporal",
"arg1_id": "NCT03236246_exc_T3",
"arg2_id": "NCT03236246_exc_T6",
"normalized": []
},
{
"id": "NCT03236246_exc_R6",
"type": "Subsumes",
"arg1_id": "NCT03236246_exc_T8",
"arg2_id": "NCT03236246_exc_T9",
"normalized": []
},
{
"id": "NCT03236246_exc_R7",
"type": "Has_index",
"arg1_id": "NCT03236246_exc_T10",
"arg2_id": "NCT03236246_exc_T11",
"normalized": []
},
{
"id": "NCT03236246_exc_R8",
"type": "Has_index",
"arg1_id": "NCT03236246_exc_T13",
"arg2_id": "NCT03236246_exc_T14",
"normalized": []
},
{
"id": "NCT03236246_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT03236246_exc_T12",
"arg2_id": "NCT03236246_exc_T13",
"normalized": []
}
] |
NCT03236246_inc | NCT03236246 | [
{
"id": "NCT03236246_inc_text",
"type": "inclusion",
"text": [
"Estimated glomerular filtration rate =20 mL/min and <60 mL/min\nHgb =8.5 g/dL and =11.5 g/dL\nSerum ferritin =500 ng/mL and transferrin saturation (TSAT) =25%\nSerum intact parathyroid hormone =600 pg/mL\n"
],
"offsets": [
[
0,
201
]
]
}
] | [
{
"id": "NCT03236246_inc_T1",
"type": "Measurement",
"text": [
"Estimated glomerular filtration rate"
],
"offsets": [
[
0,
36
]
],
"normalized": []
},
{
"id": "NCT03236246_inc_T2",
"type": "Value",
"text": [
"=20 mL/min and <60 mL/min"
],
"offsets": [
[
37,
62
]
],
"normalized": []
},
{
"id": "NCT03236246_inc_T3",
"type": "Measurement",
"text": [
"Hgb"
],
"offsets": [
[
63,
66
]
],
"normalized": []
},
{
"id": "NCT03236246_inc_T4",
"type": "Value",
"text": [
"=8.5 g/dL and =11.5 g/dL"
],
"offsets": [
[
67,
91
]
],
"normalized": []
},
{
"id": "NCT03236246_inc_T5",
"type": "Measurement",
"text": [
"Serum ferritin"
],
"offsets": [
[
92,
106
]
],
"normalized": []
},
{
"id": "NCT03236246_inc_T6",
"type": "Value",
"text": [
"=500 ng/mL"
],
"offsets": [
[
107,
117
]
],
"normalized": []
},
{
"id": "NCT03236246_inc_T7",
"type": "Measurement",
"text": [
"transferrin saturation"
],
"offsets": [
[
122,
144
]
],
"normalized": []
},
{
"id": "NCT03236246_inc_T8",
"type": "Measurement",
"text": [
"TSAT"
],
"offsets": [
[
146,
150
]
],
"normalized": []
},
{
"id": "NCT03236246_inc_T9",
"type": "Value",
"text": [
"=25%"
],
"offsets": [
[
152,
156
]
],
"normalized": []
},
{
"id": "NCT03236246_inc_T10",
"type": "Measurement",
"text": [
"Serum intact parathyroid hormone"
],
"offsets": [
[
157,
189
]
],
"normalized": []
},
{
"id": "NCT03236246_inc_T11",
"type": "Value",
"text": [
"=600 pg/mL"
],
"offsets": [
[
190,
200
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03236246_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03236246_inc_T1",
"arg2_id": "NCT03236246_inc_T2",
"normalized": []
},
{
"id": "NCT03236246_inc_R2",
"type": "Has_value",
"arg1_id": "NCT03236246_inc_T3",
"arg2_id": "NCT03236246_inc_T4",
"normalized": []
},
{
"id": "NCT03236246_inc_R3",
"type": "Subsumes",
"arg1_id": "NCT03236246_inc_T7",
"arg2_id": "NCT03236246_inc_T8",
"normalized": []
},
{
"id": "NCT03236246_inc_R4",
"type": "Has_value",
"arg1_id": "NCT03236246_inc_T7",
"arg2_id": "NCT03236246_inc_T9",
"normalized": []
},
{
"id": "NCT03236246_inc_R5",
"type": "Has_value",
"arg1_id": "NCT03236246_inc_T5",
"arg2_id": "NCT03236246_inc_T6",
"normalized": []
},
{
"id": "NCT03236246_inc_R6",
"type": "Has_value",
"arg1_id": "NCT03236246_inc_T10",
"arg2_id": "NCT03236246_inc_T11",
"normalized": []
}
] |
NCT03241368_exc | NCT03241368 | [
{
"id": "NCT03241368_exc_text",
"type": "exclusion",
"text": [
"Subject has indeterminate, ulcerative, antibiotic-associated colitis. \nSubject has stool positive for ova and parasite and for Clostridium difficule toxins within 3 months prior to enrollment. \nSubject with other known infectious cause of abdominal symptoms. \nSubject with clinical evidence of renal disease with the past 6 months, defined as estimated glomerular filtration rate (GFR) outside the normal reference range. \nSubject with known history of intestinal obstruction or current obstructive symptoms, such as severe abdominal pain with accompanying nausea or vomiting, based on investigator judgment. \nSubject with a diagnosis of gastroparesis or small bowel or large bowel dysmotility. \nSubjects with a history of small bowel or colonic resection. \nSubject with any current condition believed to have an increased risk of capsule retention such as suspected or known bowel obstruction, stricture, or fistula. \nSubject has used non-steroidal anti-inflammatory drugs including aspirin, two times per week, during the 4 weeks preceding enrollment. Low dose aspirin regimens (< 100 mg daily) are acceptable and not exclusionary. \nSubject suffers from any condition, such as swallowing problems, that precludes compliance with study and/or device instructions. \nSubject with cardiac pacemaker or other implanted electromedical device. \nSubject has an allergy or other known contraindication to the medications used in the study. \nSubject is pregnant (documented by a positive pregnancy test) or is actively breast-feeding. \nSubject is considered to be a part of a vulnerable population (eg. prisoners or those without sufficient mental capacity). \nSubject has a known contraindication to MRE or IC. \nSubject has participated in a drug or device research study within 30 days of enrollment that may interfere with the subject's safety or ability to participate in the study. \nSubject has any medical condition that would make it unsafe for them to participate, per Investigator's descretion \n \n"
],
"offsets": [
[
0,
2006
]
]
}
] | [
{
"id": "NCT03241368_exc_T1",
"type": "Condition",
"text": [
"colitis"
],
"offsets": [
[
61,
68
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T2",
"type": "Observation",
"text": [
"antibiotic-associated"
],
"offsets": [
[
39,
60
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T3",
"type": "Observation",
"text": [
"ulcerative"
],
"offsets": [
[
27,
37
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T4",
"type": "Observation",
"text": [
"indeterminate"
],
"offsets": [
[
12,
25
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T5",
"type": "Measurement",
"text": [
"stool"
],
"offsets": [
[
83,
88
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T6",
"type": "Value",
"text": [
"positive for ova"
],
"offsets": [
[
89,
105
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T7",
"type": "Value",
"text": [
"parasite",
"positive for"
],
"offsets": [
[
110,
118
],
[
89,
101
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T8",
"type": "Value",
"text": [
"Clostridium difficule toxins",
"positive for"
],
"offsets": [
[
127,
155
],
[
89,
101
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T9",
"type": "Temporal",
"text": [
"within 3 months prior"
],
"offsets": [
[
156,
177
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T10",
"type": "Reference_point",
"text": [
"enrollment"
],
"offsets": [
[
181,
191
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T12",
"type": "Condition",
"text": [
"renal disease"
],
"offsets": [
[
294,
307
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T13",
"type": "Temporal",
"text": [
"with the past 6 months"
],
"offsets": [
[
308,
330
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T14",
"type": "Measurement",
"text": [
"estimated glomerular filtration rate (GFR)"
],
"offsets": [
[
343,
385
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T15",
"type": "Value",
"text": [
"outside"
],
"offsets": [
[
386,
393
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T16",
"type": "Reference_point",
"text": [
"normal reference range"
],
"offsets": [
[
398,
420
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T17",
"type": "Condition",
"text": [
"intestinal obstruction"
],
"offsets": [
[
453,
475
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T18",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
442,
449
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T19",
"type": "Condition",
"text": [
"obstructive symptoms"
],
"offsets": [
[
487,
507
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T20",
"type": "Temporal",
"text": [
"current"
],
"offsets": [
[
479,
486
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T21",
"type": "Condition",
"text": [
"severe abdominal pain"
],
"offsets": [
[
517,
538
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T22",
"type": "Condition",
"text": [
"nausea"
],
"offsets": [
[
557,
563
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T23",
"type": "Condition",
"text": [
"vomiting"
],
"offsets": [
[
567,
575
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T24",
"type": "Condition",
"text": [
"gastroparesis"
],
"offsets": [
[
638,
651
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T25",
"type": "Condition",
"text": [
"small bowel"
],
"offsets": [
[
655,
666
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T26",
"type": "Condition",
"text": [
"large bowel dysmotility"
],
"offsets": [
[
670,
693
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T27",
"type": "Condition",
"text": [
"small bowel",
"resection"
],
"offsets": [
[
723,
734
],
[
746,
755
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T28",
"type": "Condition",
"text": [
"colonic resection"
],
"offsets": [
[
738,
755
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T29",
"type": "Observation",
"text": [
"history"
],
"offsets": [
[
712,
719
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T31",
"type": "Drug",
"text": [
"non-steroidal anti-inflammatory drugs"
],
"offsets": [
[
936,
973
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T32",
"type": "Drug",
"text": [
"aspirin"
],
"offsets": [
[
984,
991
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T33",
"type": "Multiplier",
"text": [
"two times per week"
],
"offsets": [
[
993,
1011
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T34",
"type": "Temporal",
"text": [
"during the 4 weeks preceding"
],
"offsets": [
[
1013,
1041
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T35",
"type": "Reference_point",
"text": [
"enrollment"
],
"offsets": [
[
1042,
1052
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T36",
"type": "Drug",
"text": [
"aspirin"
],
"offsets": [
[
1063,
1070
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T37",
"type": "Multiplier",
"text": [
"< 100 mg daily"
],
"offsets": [
[
1081,
1095
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T38",
"type": "Qualifier",
"text": [
"Low dose"
],
"offsets": [
[
1054,
1062
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T40",
"type": "Condition",
"text": [
"condition"
],
"offsets": [
[
1160,
1169
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T41",
"type": "Condition",
"text": [
"swallowing problems"
],
"offsets": [
[
1179,
1198
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T42",
"type": "Negation",
"text": [
"precludes"
],
"offsets": [
[
1205,
1214
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T45",
"type": "Scope",
"text": [
"compliance with study and/or device instructions"
],
"offsets": [
[
1215,
1263
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T46",
"type": "Scope",
"text": [
"condition, such as swallowing problems"
],
"offsets": [
[
1160,
1198
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T47",
"type": "Device",
"text": [
"cardiac pacemaker"
],
"offsets": [
[
1279,
1296
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T48",
"type": "Device",
"text": [
"implanted electromedical device"
],
"offsets": [
[
1306,
1337
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T49",
"type": "Condition",
"text": [
"allergy"
],
"offsets": [
[
1355,
1362
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T50",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
1378,
1394
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T51",
"type": "Drug",
"text": [
"medications used in the study"
],
"offsets": [
[
1402,
1431
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T52",
"type": "Scope",
"text": [
"allergy or other known contraindication"
],
"offsets": [
[
1355,
1394
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T53",
"type": "Condition",
"text": [
"pregnant"
],
"offsets": [
[
1445,
1453
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T54",
"type": "Value",
"text": [
"positive"
],
"offsets": [
[
1471,
1479
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T55",
"type": "Measurement",
"text": [
"pregnancy test"
],
"offsets": [
[
1480,
1494
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T56",
"type": "Qualifier",
"text": [
"actively"
],
"offsets": [
[
1502,
1510
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T57",
"type": "Temporal",
"text": [
"actively"
],
"offsets": [
[
1502,
1510
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T58",
"type": "Observation",
"text": [
"breast-feeding"
],
"offsets": [
[
1511,
1525
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T59",
"type": "Person",
"text": [
"part of a vulnerable population"
],
"offsets": [
[
1558,
1589
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T60",
"type": "Person",
"text": [
"prisoners"
],
"offsets": [
[
1595,
1604
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T61",
"type": "Condition",
"text": [
"without sufficient mental capacity"
],
"offsets": [
[
1614,
1648
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T62",
"type": "Scope",
"text": [
"prisoners or those without sufficient mental capacity"
],
"offsets": [
[
1595,
1648
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T63",
"type": "Condition",
"text": [
"contraindication"
],
"offsets": [
[
1672,
1688
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T64",
"type": "Procedure",
"text": [
"MRE"
],
"offsets": [
[
1692,
1695
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T65",
"type": "Procedure",
"text": [
"IC"
],
"offsets": [
[
1699,
1701
]
],
"normalized": []
},
{
"id": "NCT03241368_exc_T66",
"type": "Scope",
"text": [
"MRE or IC"
],
"offsets": [
[
1692,
1701
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03241368_exc_R4",
"type": "Has_value",
"arg1_id": "NCT03241368_exc_T5",
"arg2_id": "NCT03241368_exc_T6",
"normalized": []
},
{
"id": "NCT03241368_exc_R5",
"type": "Has_value",
"arg1_id": "NCT03241368_exc_T5",
"arg2_id": "NCT03241368_exc_T7",
"normalized": []
},
{
"id": "NCT03241368_exc_R6",
"type": "Has_value",
"arg1_id": "NCT03241368_exc_T5",
"arg2_id": "NCT03241368_exc_T8",
"normalized": []
},
{
"id": "NCT03241368_exc_R7",
"type": "Has_index",
"arg1_id": "NCT03241368_exc_T9",
"arg2_id": "NCT03241368_exc_T10",
"normalized": []
},
{
"id": "NCT03241368_exc_R8",
"type": "Has_temporal",
"arg1_id": "NCT03241368_exc_T5",
"arg2_id": "NCT03241368_exc_T9",
"normalized": []
},
{
"id": "NCT03241368_exc_R9",
"type": "Has_temporal",
"arg1_id": "NCT03241368_exc_T12",
"arg2_id": "NCT03241368_exc_T13",
"normalized": []
},
{
"id": "NCT03241368_exc_R10",
"type": "Has_index",
"arg1_id": "NCT03241368_exc_T15",
"arg2_id": "NCT03241368_exc_T16",
"normalized": []
},
{
"id": "NCT03241368_exc_R11",
"type": "Has_value",
"arg1_id": "NCT03241368_exc_T14",
"arg2_id": "NCT03241368_exc_T15",
"normalized": []
},
{
"id": "NCT03241368_exc_R12",
"type": "Has_temporal",
"arg1_id": "NCT03241368_exc_T17",
"arg2_id": "NCT03241368_exc_T18",
"normalized": []
},
{
"id": "NCT03241368_exc_R13",
"type": "Has_temporal",
"arg1_id": "NCT03241368_exc_T19",
"arg2_id": "NCT03241368_exc_T20",
"normalized": []
},
{
"id": "NCT03241368_exc_R14",
"type": "Subsumes",
"arg1_id": "NCT03241368_exc_T19",
"arg2_id": "NCT03241368_exc_T21",
"normalized": []
},
{
"id": "NCT03241368_exc_R15",
"type": "Subsumes",
"arg1_id": "NCT03241368_exc_T19",
"arg2_id": "NCT03241368_exc_T22",
"normalized": []
},
{
"id": "NCT03241368_exc_R16",
"type": "Subsumes",
"arg1_id": "NCT03241368_exc_T19",
"arg2_id": "NCT03241368_exc_T23",
"normalized": []
},
{
"id": "NCT03241368_exc_R17",
"type": "Has_index",
"arg1_id": "NCT03241368_exc_T34",
"arg2_id": "NCT03241368_exc_T35",
"normalized": []
},
{
"id": "NCT03241368_exc_R19",
"type": "Subsumes",
"arg1_id": "NCT03241368_exc_T31",
"arg2_id": "NCT03241368_exc_T32",
"normalized": []
},
{
"id": "NCT03241368_exc_R18",
"type": "Has_multiplier",
"arg1_id": "NCT03241368_exc_T31",
"arg2_id": "NCT03241368_exc_T33",
"normalized": []
},
{
"id": "NCT03241368_exc_R20",
"type": "Has_temporal",
"arg1_id": "NCT03241368_exc_T31",
"arg2_id": "NCT03241368_exc_T34",
"normalized": []
},
{
"id": "NCT03241368_exc_R21",
"type": "Has_qualifier",
"arg1_id": "NCT03241368_exc_T36",
"arg2_id": "NCT03241368_exc_T38",
"normalized": []
},
{
"id": "NCT03241368_exc_R22",
"type": "Has_multiplier",
"arg1_id": "NCT03241368_exc_T38",
"arg2_id": "NCT03241368_exc_T37",
"normalized": []
},
{
"id": "NCT03241368_exc_R23",
"type": "Subsumes",
"arg1_id": "NCT03241368_exc_T40",
"arg2_id": "NCT03241368_exc_T41",
"normalized": []
},
{
"id": "NCT03241368_exc_R24",
"type": "Has_negation",
"arg1_id": "NCT03241368_exc_T45",
"arg2_id": "NCT03241368_exc_T42",
"normalized": []
},
{
"id": "NCT03241368_exc_R25",
"type": "Subsumes",
"arg1_id": "NCT03241368_exc_T46",
"arg2_id": "NCT03241368_exc_T45",
"normalized": []
},
{
"id": "NCT03241368_exc_R26",
"type": "AND",
"arg1_id": "NCT03241368_exc_T52",
"arg2_id": "NCT03241368_exc_T51",
"normalized": []
},
{
"id": "NCT03241368_exc_R27",
"type": "Has_value",
"arg1_id": "NCT03241368_exc_T55",
"arg2_id": "NCT03241368_exc_T54",
"normalized": []
},
{
"id": "NCT03241368_exc_R28",
"type": "Has_qualifier",
"arg1_id": "NCT03241368_exc_T58",
"arg2_id": "NCT03241368_exc_T56",
"normalized": []
},
{
"id": "NCT03241368_exc_R30",
"type": "AND",
"arg1_id": "NCT03241368_exc_T53",
"arg2_id": "NCT03241368_exc_T55",
"normalized": []
},
{
"id": "NCT03241368_exc_R31",
"type": "Subsumes",
"arg1_id": "NCT03241368_exc_T59",
"arg2_id": "NCT03241368_exc_T62",
"normalized": []
},
{
"id": "NCT03241368_exc_R32",
"type": "Has_scope",
"arg1_id": "NCT03241368_exc_T63",
"arg2_id": "NCT03241368_exc_T66",
"normalized": []
}
] |
NCT03241368_inc | NCT03241368 | [
{
"id": "NCT03241368_inc_text",
"type": "inclusion",
"text": [
"Subject has provided informed consent. \nSubject is ≥ 18 years of age \nSubject is willing and able to comply with all aspects of treatment and evaluation schedule. \nSubject has known CD and a recent history (within last 2 years) of mucosal disease (diagnosis based on radiologic, endoscopic, or histological evidence). \n"
],
"offsets": [
[
0,
319
]
]
}
] | [
{
"id": "NCT03241368_inc_T1",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
65,
68
]
],
"normalized": []
},
{
"id": "NCT03241368_inc_T2",
"type": "Value",
"text": [
"≥ 18 years"
],
"offsets": [
[
51,
61
]
],
"normalized": []
},
{
"id": "NCT03241368_inc_T5",
"type": "Condition",
"text": [
"mucosal disease"
],
"offsets": [
[
231,
246
]
],
"normalized": []
},
{
"id": "NCT03241368_inc_T6",
"type": "Observation",
"text": [
"radiologic",
"evidence"
],
"offsets": [
[
267,
277
],
[
307,
315
]
],
"normalized": []
},
{
"id": "NCT03241368_inc_T7",
"type": "Observation",
"text": [
"endoscopic",
"evidence"
],
"offsets": [
[
279,
289
],
[
307,
315
]
],
"normalized": []
},
{
"id": "NCT03241368_inc_T8",
"type": "Observation",
"text": [
"histological evidence"
],
"offsets": [
[
294,
315
]
],
"normalized": []
},
{
"id": "NCT03241368_inc_T9",
"type": "Scope",
"text": [
"diagnosis based on radiologic, endoscopic, or histological evidence"
],
"offsets": [
[
248,
315
]
],
"normalized": []
},
{
"id": "NCT03241368_inc_T10",
"type": "Temporal",
"text": [
"within last 2 years"
],
"offsets": [
[
207,
226
]
],
"normalized": []
},
{
"id": "NCT03241368_inc_T11",
"type": "Temporal",
"text": [
"recent history"
],
"offsets": [
[
191,
205
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03241368_inc_R1",
"type": "Has_value",
"arg1_id": "NCT03241368_inc_T1",
"arg2_id": "NCT03241368_inc_T2",
"normalized": []
},
{
"id": "NCT03241368_inc_R2",
"type": "Has_scope",
"arg1_id": "NCT03241368_inc_T5",
"arg2_id": "NCT03241368_inc_T9",
"normalized": []
},
{
"id": "NCT03241368_inc_R3",
"type": "Has_temporal",
"arg1_id": "NCT03241368_inc_T5",
"arg2_id": "NCT03241368_inc_T11",
"normalized": []
},
{
"id": "NCT03241368_inc_R4",
"type": "Has_temporal",
"arg1_id": "NCT03241368_inc_T11",
"arg2_id": "NCT03241368_inc_T10",
"normalized": []
}
] |
NCT03247413_exc | NCT03247413 | [
{
"id": "NCT03247413_exc_text",
"type": "exclusion",
"text": [
"patient not previously scheduled for radiofrequency ablation of the cervical, thoracic, or lumbar facets, or sacroiliac joints\non anticoagulation\nhave a pacemaker\nage less than 18 years old\nnon-English speaking\n"
],
"offsets": [
[
0,
211
]
]
}
] | [
{
"id": "NCT03247413_exc_T1",
"type": "Negation",
"text": [
"not"
],
"offsets": [
[
8,
11
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T2",
"type": "Temporal",
"text": [
"previously"
],
"offsets": [
[
12,
22
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T3",
"type": "Mood",
"text": [
"scheduled for"
],
"offsets": [
[
23,
36
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T4",
"type": "Procedure",
"text": [
"radiofrequency ablation"
],
"offsets": [
[
37,
60
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T5",
"type": "Qualifier",
"text": [
"cervical",
"facets"
],
"offsets": [
[
68,
76
],
[
98,
104
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T6",
"type": "Qualifier",
"text": [
"thoracic",
"facets"
],
"offsets": [
[
78,
86
],
[
98,
104
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T7",
"type": "Qualifier",
"text": [
"lumbar facets"
],
"offsets": [
[
91,
104
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T8",
"type": "Qualifier",
"text": [
"sacroiliac joints"
],
"offsets": [
[
109,
126
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T9",
"type": "Scope",
"text": [
"cervical, thoracic, or lumbar facets, or sacroiliac joints"
],
"offsets": [
[
68,
126
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T10",
"type": "Procedure",
"text": [
"anticoagulation"
],
"offsets": [
[
130,
145
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T11",
"type": "Device",
"text": [
"pacemaker"
],
"offsets": [
[
153,
162
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T12",
"type": "Drug",
"text": [
"anticoagulation"
],
"offsets": [
[
130,
145
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T13",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
163,
166
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T14",
"type": "Value",
"text": [
"less than 18 years old"
],
"offsets": [
[
167,
189
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T15",
"type": "Observation",
"text": [
"English speaking"
],
"offsets": [
[
194,
210
]
],
"normalized": []
},
{
"id": "NCT03247413_exc_T16",
"type": "Negation",
"text": [
"non"
],
"offsets": [
[
190,
193
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03247413_exc_R1",
"type": "Has_mood",
"arg1_id": "NCT03247413_exc_T4",
"arg2_id": "NCT03247413_exc_T3",
"normalized": []
},
{
"id": "NCT03247413_exc_R2",
"type": "Has_temporal",
"arg1_id": "NCT03247413_exc_T4",
"arg2_id": "NCT03247413_exc_T2",
"normalized": []
},
{
"id": "NCT03247413_exc_R3",
"type": "Has_negation",
"arg1_id": "NCT03247413_exc_T4",
"arg2_id": "NCT03247413_exc_T1",
"normalized": []
},
{
"id": "NCT03247413_exc_R4",
"type": "Has_scope",
"arg1_id": "NCT03247413_exc_T4",
"arg2_id": "NCT03247413_exc_T9",
"normalized": []
},
{
"id": "NCT03247413_exc_R6",
"type": "Has_value",
"arg1_id": "NCT03247413_exc_T13",
"arg2_id": "NCT03247413_exc_T14",
"normalized": []
},
{
"id": "NCT03247413_exc_R7",
"type": "Has_negation",
"arg1_id": "NCT03247413_exc_T15",
"arg2_id": "NCT03247413_exc_T16",
"normalized": []
}
] |
NCT03247413_inc | NCT03247413 | [
{
"id": "NCT03247413_inc_text",
"type": "inclusion",
"text": [
"patients with a diagnosis of either cervical, thoracic, or lumbar facet or sacroiliac joint pain who have responded to medial branch blocks and are already scheduled for bilateral radiofrequency ablations\nage greater than 18 years old\nEnglish speaking\n"
],
"offsets": [
[
0,
252
]
]
}
] | [
{
"id": "NCT03247413_inc_T1",
"type": "Condition",
"text": [
"cervical",
"joint pain"
],
"offsets": [
[
36,
44
],
[
86,
96
]
],
"normalized": []
},
{
"id": "NCT03247413_inc_T2",
"type": "Condition",
"text": [
"thoracic",
"joint pain"
],
"offsets": [
[
46,
54
],
[
86,
96
]
],
"normalized": []
},
{
"id": "NCT03247413_inc_T3",
"type": "Condition",
"text": [
"lumbar facet",
"joint pain"
],
"offsets": [
[
59,
71
],
[
86,
96
]
],
"normalized": []
},
{
"id": "NCT03247413_inc_T4",
"type": "Condition",
"text": [
"sacroiliac joint pain"
],
"offsets": [
[
75,
96
]
],
"normalized": []
},
{
"id": "NCT03247413_inc_T5",
"type": "Procedure",
"text": [
"medial branch blocks"
],
"offsets": [
[
119,
139
]
],
"normalized": []
},
{
"id": "NCT03247413_inc_T6",
"type": "Observation",
"text": [
"responded"
],
"offsets": [
[
106,
115
]
],
"normalized": []
},
{
"id": "NCT03247413_inc_T7",
"type": "Mood",
"text": [
"scheduled for"
],
"offsets": [
[
156,
169
]
],
"normalized": []
},
{
"id": "NCT03247413_inc_T8",
"type": "Procedure",
"text": [
"bilateral radiofrequency ablations"
],
"offsets": [
[
170,
204
]
],
"normalized": []
},
{
"id": "NCT03247413_inc_T9",
"type": "Person",
"text": [
"age"
],
"offsets": [
[
205,
208
]
],
"normalized": []
},
{
"id": "NCT03247413_inc_T10",
"type": "Value",
"text": [
"greater than 18 years old"
],
"offsets": [
[
209,
234
]
],
"normalized": []
},
{
"id": "NCT03247413_inc_T11",
"type": "Observation",
"text": [
"English speaking"
],
"offsets": [
[
235,
251
]
],
"normalized": []
},
{
"id": "NCT03247413_inc_T12",
"type": "Scope",
"text": [
"cervical, thoracic, or lumbar facet or sacroiliac joint pain"
],
"offsets": [
[
36,
96
]
],
"normalized": []
}
] | [] | [] | [
{
"id": "NCT03247413_inc_R1",
"type": "AND",
"arg1_id": "NCT03247413_inc_T6",
"arg2_id": "NCT03247413_inc_T5",
"normalized": []
},
{
"id": "NCT03247413_inc_R2",
"type": "Has_mood",
"arg1_id": "NCT03247413_inc_T8",
"arg2_id": "NCT03247413_inc_T7",
"normalized": []
},
{
"id": "NCT03247413_inc_R3",
"type": "Has_value",
"arg1_id": "NCT03247413_inc_T9",
"arg2_id": "NCT03247413_inc_T10",
"normalized": []
}
] |