Datasets:

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[ { "id": "NCT03066440_exc_text", "type": "exclusion", "text": [ "Age > 18 Years\nPhysician discretion\nSeptic or hypovolemic shock\nSigns of life-threatening cerebral edema or multi-organ failure upon presentation to the emergency room or pediatric intensive care unit\nEnrollment time more than 1 hr since arrival to emergency room or PICU\nPregnancy\n" ], "offsets": [ [ 0, 282 ] ] } ]

[ { "id": "NCT03066440_exc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T2", "type": "Value", "text": [ "> 18 Years" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T4", "type": "Condition", "text": [ "ptic o", "ock\nS" ], "offsets": [ [ 38, 44 ], [ 60, 65 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T5", "type": "Condition", "text": [ "hypovolemic shock" ], "offsets": [ [ 46, 63 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T6", "type": "Condition", "text": [ "cerebral edema" ], "offsets": [ [ 90, 104 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T7", "type": "Condition", "text": [ "multi-organ failure" ], "offsets": [ [ 108, 127 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T8", "type": "Mood", "text": [ "Signs of" ], "offsets": [ [ 64, 72 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T9", "type": "Qualifier", "text": [ "life-threatening" ], "offsets": [ [ 73, 89 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T10", "type": "Scope", "text": [ "cerebral edema or multi-organ failure" ], "offsets": [ [ 90, 127 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T11", "type": "Visit", "text": [ "emergency room" ], "offsets": [ [ 153, 167 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T12", "type": "Visit", "text": [ "pediatric intensive care unit" ], "offsets": [ [ 171, 200 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T13", "type": "Observation", "text": [ "Enrollment" ], "offsets": [ [ 201, 211 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T14", "type": "Temporal", "text": [ "more than 1 hr since arrival to emergency room or PICU" ], "offsets": [ [ 217, 271 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T15", "type": "Visit", "text": [ "emergency room" ], "offsets": [ [ 249, 263 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T16", "type": "Visit", "text": [ "PICU" ], "offsets": [ [ 267, 271 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T17", "type": "Temporal", "text": [ "upon presentation to the emergency room or pediatric intensive care unit" ], "offsets": [ [ 128, 200 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T18", "type": "Reference_point", "text": [ "presentation to the emergency room or pediatric intensive care unit" ], "offsets": [ [ 133, 200 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T19", "type": "Scope", "text": [ "emergency room or pediatric intensive care unit" ], "offsets": [ [ 153, 200 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T20", "type": "Scope", "text": [ "emergency room or PICU" ], "offsets": [ [ 249, 271 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T21", "type": "Reference_point", "text": [ "arrival to emergency room or PICU" ], "offsets": [ [ 238, 271 ] ], "normalized": [] }, { "id": "NCT03066440_exc_T22", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 272, 281 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03066440_exc_R1", "type": "Has_value", "arg1_id": "NCT03066440_exc_T1", "arg2_id": "NCT03066440_exc_T2", "normalized": [] }, { "id": "NCT03066440_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03066440_exc_T10", "arg2_id": "NCT03066440_exc_T9", "normalized": [] }, { "id": "NCT03066440_exc_R3", "type": "Has_mood", "arg1_id": "NCT03066440_exc_T10", "arg2_id": "NCT03066440_exc_T8", "normalized": [] }, { "id": "NCT03066440_exc_R5", "type": "Has_index", "arg1_id": "NCT03066440_exc_T17", "arg2_id": "NCT03066440_exc_T18", "normalized": [] }, { "id": "NCT03066440_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03066440_exc_T10", "arg2_id": "NCT03066440_exc_T17", "normalized": [] }, { "id": "NCT03066440_exc_R7", "type": "Has_index", "arg1_id": "NCT03066440_exc_T14", "arg2_id": "NCT03066440_exc_T21", "normalized": [] }, { "id": "NCT03066440_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03066440_exc_T13", "arg2_id": "NCT03066440_exc_T14", "normalized": [] } ]

[ { "id": "NCT03066440_inc_text", "type": "inclusion", "text": [ "Age between 0 and 18 years\nVenous pH less than 7.25\nKetonuria as confirmed on urine point-of-care testing or urinalysis\nHyperglycemia (Serum glucose > 200 mg/dl)\nSerum bicarbonate <15 mmol/L\nPICU admission\n" ], "offsets": [ [ 0, 206 ] ] } ]

[ { "id": "NCT03066440_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T2", "type": "Value", "text": [ "between 0 and 18 years" ], "offsets": [ [ 4, 26 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T3", "type": "Measurement", "text": [ "Venous pH" ], "offsets": [ [ 27, 36 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T4", "type": "Value", "text": [ "less than 7.25" ], "offsets": [ [ 37, 51 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T5", "type": "Condition", "text": [ "Ketonuria" ], "offsets": [ [ 52, 61 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T6", "type": "Measurement", "text": [ "urine point-of-care testing" ], "offsets": [ [ 78, 105 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T7", "type": "Measurement", "text": [ "urinalysis" ], "offsets": [ [ 109, 119 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T8", "type": "Scope", "text": [ "urine point-of-care testing or urinalysis" ], "offsets": [ [ 78, 119 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T9", "type": "Condition", "text": [ "Hyperglycemia" ], "offsets": [ [ 120, 133 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T10", "type": "Measurement", "text": [ "Serum glucose" ], "offsets": [ [ 135, 148 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T11", "type": "Value", "text": [ "> 200 mg/dl" ], "offsets": [ [ 149, 160 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T12", "type": "Scope", "text": [ "Serum glucose > 200 mg/dl" ], "offsets": [ [ 135, 160 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T13", "type": "Measurement", "text": [ "Serum bicarbonate" ], "offsets": [ [ 162, 179 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T14", "type": "Value", "text": [ "<15 mmol/L" ], "offsets": [ [ 180, 190 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T15", "type": "Visit", "text": [ "PICU" ], "offsets": [ [ 191, 195 ] ], "normalized": [] }, { "id": "NCT03066440_inc_T16", "type": "Procedure", "text": [ "admission" ], "offsets": [ [ 196, 205 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03066440_inc_R1", "type": "Has_value", "arg1_id": "NCT03066440_inc_T1", "arg2_id": "NCT03066440_inc_T2", "normalized": [] }, { "id": "NCT03066440_inc_R2", "type": "Has_value", "arg1_id": "NCT03066440_inc_T3", "arg2_id": "NCT03066440_inc_T4", "normalized": [] }, { "id": "NCT03066440_inc_R3", "type": "Has_scope", "arg1_id": "NCT03066440_inc_T5", "arg2_id": "NCT03066440_inc_T8", "normalized": [] }, { "id": "NCT03066440_inc_R4", "type": "Has_value", "arg1_id": "NCT03066440_inc_T10", "arg2_id": "NCT03066440_inc_T11", "normalized": [] }, { "id": "NCT03066440_inc_R5", "type": "Subsumes", "arg1_id": "NCT03066440_inc_T9", "arg2_id": "NCT03066440_inc_T12", "normalized": [] }, { "id": "NCT03066440_inc_R6", "type": "Has_value", "arg1_id": "NCT03066440_inc_T13", "arg2_id": "NCT03066440_inc_T14", "normalized": [] }, { "id": "NCT03066440_inc_R7", "type": "AND", "arg1_id": "NCT03066440_inc_T16", "arg2_id": "NCT03066440_inc_T15", "normalized": [] } ]

[ { "id": "NCT03067740_exc_text", "type": "exclusion", "text": [ "The diagnosis of developmental delay, attention deficit disorder, chronic pain, psychiatric illness, previous open abdominal surgery, the presence of a gastrostomy, ventricular-peritoneal shunt or other abdominal prosthesis, immunosuppression, and those allergic to any of the medications.\n" ], "offsets": [ [ 0, 290 ] ] } ]

[ { "id": "NCT03067740_exc_T1", "type": "Condition", "text": [ "developmental delay" ], "offsets": [ [ 17, 36 ] ], "normalized": [] }, { "id": "NCT03067740_exc_T2", "type": "Condition", "text": [ "attention deficit disorder" ], "offsets": [ [ 38, 64 ] ], "normalized": [] }, { "id": "NCT03067740_exc_T3", "type": "Condition", "text": [ "chronic pain" ], "offsets": [ [ 66, 78 ] ], "normalized": [] }, { "id": "NCT03067740_exc_T4", "type": "Condition", "text": [ "psychiatric illness" ], "offsets": [ [ 80, 99 ] ], "normalized": [] }, { "id": "NCT03067740_exc_T5", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 101, 109 ] ], "normalized": [] }, { "id": "NCT03067740_exc_T6", "type": "Procedure", "text": [ "open abdominal surgery" ], "offsets": [ [ 110, 132 ] ], "normalized": [] }, { "id": "NCT03067740_exc_T7", "type": "Device", "text": [ "gastrostomy" ], "offsets": [ [ 152, 163 ] ], "normalized": [] }, { "id": "NCT03067740_exc_T8", "type": "Device", "text": [ "ventricular-peritoneal shunt" ], "offsets": [ [ 165, 193 ] ], "normalized": [] }, { "id": "NCT03067740_exc_T9", "type": "Device", "text": [ "abdominal prosthesis" ], "offsets": [ [ 203, 223 ] ], "normalized": [] }, { "id": "NCT03067740_exc_T10", "type": "Condition", "text": [ "immunosuppression" ], "offsets": [ [ 225, 242 ] ], "normalized": [] }, { "id": "NCT03067740_exc_T11", "type": "Condition", "text": [ "allergic" ], "offsets": [ [ 254, 262 ] ], "normalized": [] }, { "id": "NCT03067740_exc_T12", "type": "Drug", "text": [ "any of the medications" ], "offsets": [ [ 266, 288 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03067740_exc_R1", "type": "AND", "arg1_id": "NCT03067740_exc_T11", "arg2_id": "NCT03067740_exc_T12", "normalized": [] }, { "id": "NCT03067740_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03067740_exc_T6", "arg2_id": "NCT03067740_exc_T5", "normalized": [] } ]

[ { "id": "NCT03067740_inc_text", "type": "inclusion", "text": [ "Patients are of American Society of Anesthesiologists (ASA) physical status I and II, aged 8-14 years old, of both gender, with suspected acute appendicitis scheduled for laparoscopic appendicectomy.\n" ], "offsets": [ [ 0, 200 ] ] } ]

[ { "id": "NCT03067740_inc_T1", "type": "Measurement", "text": [ "American Society of Anesthesiologists", "physical status" ], "offsets": [ [ 16, 53 ], [ 60, 75 ] ], "normalized": [] }, { "id": "NCT03067740_inc_T2", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 55, 58 ] ], "normalized": [] }, { "id": "NCT03067740_inc_T3", "type": "Value", "text": [ "I and II" ], "offsets": [ [ 76, 84 ] ], "normalized": [] }, { "id": "NCT03067740_inc_T4", "type": "Person", "text": [ "aged" ], "offsets": [ [ 86, 90 ] ], "normalized": [] }, { "id": "NCT03067740_inc_T5", "type": "Value", "text": [ "8-14 years old" ], "offsets": [ [ 91, 105 ] ], "normalized": [] }, { "id": "NCT03067740_inc_T6", "type": "Person", "text": [ "both gender" ], "offsets": [ [ 110, 121 ] ], "normalized": [] }, { "id": "NCT03067740_inc_T7", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 128, 137 ] ], "normalized": [] }, { "id": "NCT03067740_inc_T8", "type": "Condition", "text": [ "acute appendicitis" ], "offsets": [ [ 138, 156 ] ], "normalized": [] }, { "id": "NCT03067740_inc_T9", "type": "Mood", "text": [ "scheduled for" ], "offsets": [ [ 157, 170 ] ], "normalized": [] }, { "id": "NCT03067740_inc_T10", "type": "Procedure", "text": [ "laparoscopic appendicectomy" ], "offsets": [ [ 171, 198 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03067740_inc_R1", "type": "Has_value", "arg1_id": "NCT03067740_inc_T1", "arg2_id": "NCT03067740_inc_T3", "normalized": [] }, { "id": "NCT03067740_inc_R2", "type": "Has_value", "arg1_id": "NCT03067740_inc_T4", "arg2_id": "NCT03067740_inc_T5", "normalized": [] }, { "id": "NCT03067740_inc_R3", "type": "Has_mood", "arg1_id": "NCT03067740_inc_T10", "arg2_id": "NCT03067740_inc_T9", "normalized": [] }, { "id": "NCT03067740_inc_R4", "type": "Has_mood", "arg1_id": "NCT03067740_inc_T8", "arg2_id": "NCT03067740_inc_T7", "normalized": [] }, { "id": "NCT03067740_inc_R5", "type": "AND", "arg1_id": "NCT03067740_inc_T8", "arg2_id": "NCT03067740_inc_T10", "normalized": [] } ]

[ { "id": "NCT03068897_exc_text", "type": "exclusion", "text": [ "Not available for follow-up\nPregnant or breast-feeding\nChronic pain syndrome defined as use of any analgesic medication on a daily or near-daily basis\nAllergic to or intolerant of investigational medications\nContra-indications to non-steroidal anti-inflammatory drugs: 1) history of hypersensitivity to NSAIDs or aspirin 2) active or history of peptic ulcer disease, chronic dyspepsia, or active or history of gastrointestinal bleed 3) Severe heart failure (NYHA 2 or worse) 4) hypertension (JNC7 stage 2 or worse) 5) Chronic kidney disease 3 or worse 6) Current use of anti-coagulants 7) Hepatitis 8) Alcoholism\nContra-indications to muscle relaxants: 1) Concurrent use of centrally acting opioids; 2) Renal impairment; 3) Liver abnormality including cirrhosis or elevated enzymes 4) Use of any of the following medications: fluvoxamine, fluoroquinolones, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, acyclovir, ticlopidine, oral contraceptive pills\n" ], "offsets": [ [ 0, 978 ] ] } ]

[ { "id": "NCT03068897_exc_T2", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 28, 36 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T3", "type": "Condition", "text": [ "breast-feeding" ], "offsets": [ [ 40, 54 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T4", "type": "Condition", "text": [ "Chronic pain syndrome" ], "offsets": [ [ 55, 76 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T5", "type": "Drug", "text": [ "analgesic medication" ], "offsets": [ [ 99, 119 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T6", "type": "Qualifier", "text": [ "any" ], "offsets": [ [ 95, 98 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T7", "type": "Multiplier", "text": [ " a daily ", "sis\nA" ], "offsets": [ [ 122, 131 ], [ 147, 152 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T8", "type": "Multiplier", "text": [ " a ", "ar-daily basis\nA" ], "offsets": [ [ 122, 125 ], [ 136, 152 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T9", "type": "Scope", "text": [ "on a daily or near-daily basis" ], "offsets": [ [ 120, 150 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T10", "type": "Scope", "text": [ "any analgesic medication on a daily or near-daily basis" ], "offsets": [ [ 95, 150 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T11", "type": "Condition", "text": [ "Allergic" ], "offsets": [ [ 151, 159 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T12", "type": "Condition", "text": [ "intolerant" ], "offsets": [ [ 166, 176 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T13", "type": "Drug", "text": [ "investigational medications" ], "offsets": [ [ 180, 207 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T14", "type": "Scope", "text": [ "Allergic to or intolerant" ], "offsets": [ [ 151, 176 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T15", "type": "Condition", "text": [ "Contra-indications" ], "offsets": [ [ 208, 226 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T16", "type": "Drug", "text": [ "non-steroidal anti-inflammatory drugs" ], "offsets": [ [ 230, 267 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T17", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 283, 299 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T18", "type": "Drug", "text": [ "NSAIDs" ], "offsets": [ [ 303, 309 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T19", "type": "Drug", "text": [ "aspirin" ], "offsets": [ [ 313, 320 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T20", "type": "Scope", "text": [ "NSAIDs or aspirin" ], "offsets": [ [ 303, 320 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T21", "type": "Observation", "text": [ "history" ], "offsets": [ [ 272, 279 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T22", "type": "Temporal", "text": [ "active" ], "offsets": [ [ 324, 330 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T23", "type": "Observation", "text": [ "history" ], "offsets": [ [ 334, 341 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T24", "type": "Condition", "text": [ "peptic ulcer disease" ], "offsets": [ [ 345, 365 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T25", "type": "Condition", "text": [ "chronic dyspepsia" ], "offsets": [ [ 367, 384 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T26", "type": "Temporal", "text": [ "active" ], "offsets": [ [ 389, 395 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T27", "type": "Observation", "text": [ "history" ], "offsets": [ [ 399, 406 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T28", "type": "Condition", "text": [ "gastrointestinal bleed" ], "offsets": [ [ 410, 432 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T29", "type": "Scope", "text": [ "active or history" ], "offsets": [ [ 324, 341 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T30", "type": "Scope", "text": [ "peptic ulcer disease, chronic dyspepsia" ], "offsets": [ [ 345, 384 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T31", "type": "Scope", "text": [ "active or history" ], "offsets": [ [ 389, 406 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T32", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 436, 442 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T33", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 443, 456 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T34", "type": "Measurement", "text": [ "NYHA" ], "offsets": [ [ 458, 462 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T35", "type": "Value", "text": [ "2 or worse" ], "offsets": [ [ 463, 473 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T36", "type": "Scope", "text": [ "NYHA 2 or worse" ], "offsets": [ [ 458, 473 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T37", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 478, 490 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T38", "type": "Measurement", "text": [ "JNC7 stage" ], "offsets": [ [ 492, 502 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T39", "type": "Value", "text": [ "2 or worse" ], "offsets": [ [ 503, 513 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T40", "type": "Condition", "text": [ "Chronic kidney disease" ], "offsets": [ [ 518, 540 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T41", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 555, 562 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T42", "type": "Drug", "text": [ "anti-coagulants" ], "offsets": [ [ 570, 585 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T43", "type": "Condition", "text": [ "Hepatitis" ], "offsets": [ [ 589, 598 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T44", "type": "Condition", "text": [ "Alcoholism" ], "offsets": [ [ 602, 612 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T45", "type": "Scope", "text": [ "Contra-indications to non-steroidal anti-inflammatory drugs" ], "offsets": [ [ 208, 267 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T46", "type": "Scope", "text": [ "JNC7 stage 2 or worse" ], "offsets": [ [ 492, 513 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T47", "type": "Scope", "text": [ "history of hypersensitivity to NSAIDs or aspirin 2) active or history of peptic ulcer disease, chronic dyspepsia, or active or history of gastrointestinal bleed 3) Severe heart failure (NYHA 2 or worse) 4) hypertension (JNC7 stage 2 or worse) 5) Chronic kidney disease 3 or worse 6) Current use of anti-coagulants 7) Hepatitis 8) Alcoholism" ], "offsets": [ [ 272, 612 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T48", "type": "Condition", "text": [ "Contra-indications" ], "offsets": [ [ 613, 631 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T49", "type": "Drug", "text": [ "muscle relaxants" ], "offsets": [ [ 635, 651 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T50", "type": "Temporal", "text": [ "Concurrent" ], "offsets": [ [ 656, 666 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T51", "type": "Drug", "text": [ "centrally acting opioids" ], "offsets": [ [ 674, 698 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T52", "type": "Condition", "text": [ "Renal impairment" ], "offsets": [ [ 703, 719 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T53", "type": "Condition", "text": [ "Liver abnormality" ], "offsets": [ [ 724, 741 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T54", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 752, 761 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T55", "type": "Condition", "text": [ "elevated enzymes" ], "offsets": [ [ 765, 781 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T56", "type": "Scope", "text": [ "cirrhosis or elevated enzymes" ], "offsets": [ [ 752, 781 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T57", "type": "Drug", "text": [ "fluvoxamine" ], "offsets": [ [ 826, 837 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T58", "type": "Drug", "text": [ "fluoroquinolones" ], "offsets": [ [ 839, 855 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T59", "type": "Drug", "text": [ "amiodarone" ], "offsets": [ [ 857, 867 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T60", "type": "Drug", "text": [ "mexiletine" ], "offsets": [ [ 869, 879 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T61", "type": "Drug", "text": [ "propafenone" ], "offsets": [ [ 881, 892 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T62", "type": "Drug", "text": [ "verapamil" ], "offsets": [ [ 894, 903 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T63", "type": "Drug", "text": [ "cimetidine" ], "offsets": [ [ 905, 915 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T64", "type": "Drug", "text": [ "famotidine" ], "offsets": [ [ 917, 927 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T65", "type": "Drug", "text": [ "acyclovir" ], "offsets": [ [ 929, 938 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T66", "type": "Drug", "text": [ "ticlopidine" ], "offsets": [ [ 940, 951 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T67", "type": "Drug", "text": [ "oral contraceptive pills" ], "offsets": [ [ 953, 977 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T68", "type": "Scope", "text": [ "fluvoxamine, fluoroquinolones, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, acyclovir, ticlopidine, oral contraceptive pills" ], "offsets": [ [ 826, 977 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T69", "type": "Scope", "text": [ "Contra-indications to muscle relaxants" ], "offsets": [ [ 613, 651 ] ], "normalized": [] }, { "id": "NCT03068897_exc_T70", "type": "Scope", "text": [ "Concurrent use of centrally acting opioids; 2) Renal impairment; 3) Liver abnormality including cirrhosis or elevated enzymes 4) Use of any of the following medications: fluvoxamine, fluoroquinolones, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, acyclovir, ticlopidine, oral contraceptive pills" ], "offsets": [ [ 656, 977 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03068897_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03068897_exc_T5", "arg2_id": "NCT03068897_exc_T6", "normalized": [] }, { "id": "NCT03068897_exc_R2", "type": "Has_scope", "arg1_id": "NCT03068897_exc_T5", "arg2_id": "NCT03068897_exc_T9", "normalized": [] }, { "id": "NCT03068897_exc_R3", "type": "Subsumes", "arg1_id": "NCT03068897_exc_T4", "arg2_id": "NCT03068897_exc_T10", "normalized": [] }, { "id": "NCT03068897_exc_R4", "type": "AND", "arg1_id": "NCT03068897_exc_T14", "arg2_id": "NCT03068897_exc_T13", "normalized": [] }, { "id": "NCT03068897_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03068897_exc_T17", "arg2_id": "NCT03068897_exc_T21", "normalized": [] }, { "id": "NCT03068897_exc_R6", "type": "Has_scope", "arg1_id": "NCT03068897_exc_T17", "arg2_id": "NCT03068897_exc_T20", "normalized": [] }, { "id": "NCT03068897_exc_R7", "type": "Has_scope", "arg1_id": "NCT03068897_exc_T30", "arg2_id": "NCT03068897_exc_T29", "normalized": [] }, { "id": "NCT03068897_exc_R8", "type": "Has_scope", "arg1_id": "NCT03068897_exc_T28", "arg2_id": "NCT03068897_exc_T31", "normalized": [] }, { "id": "NCT03068897_exc_R9", "type": "Has_value", "arg1_id": "NCT03068897_exc_T34", "arg2_id": "NCT03068897_exc_T35", "normalized": [] }, { "id": "NCT03068897_exc_R10", "type": "Subsumes", "arg1_id": "NCT03068897_exc_T32", "arg2_id": "NCT03068897_exc_T36", "normalized": [] }, { "id": "NCT03068897_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT03068897_exc_T33", "arg2_id": "NCT03068897_exc_T32", "normalized": [] }, { "id": "NCT03068897_exc_R12", "type": "Has_value", "arg1_id": "NCT03068897_exc_T38", "arg2_id": "NCT03068897_exc_T39", "normalized": [] }, { "id": "NCT03068897_exc_R13", "type": "Has_temporal", "arg1_id": "NCT03068897_exc_T42", "arg2_id": "NCT03068897_exc_T41", "normalized": [] }, { "id": "NCT03068897_exc_R14", "type": "AND", "arg1_id": "NCT03068897_exc_T15", "arg2_id": "NCT03068897_exc_T16", "normalized": [] }, { "id": "NCT03068897_exc_R15", "type": "Has_scope", "arg1_id": "NCT03068897_exc_T37", "arg2_id": "NCT03068897_exc_T46", "normalized": [] }, { "id": "NCT03068897_exc_R16", "type": "Subsumes", "arg1_id": "NCT03068897_exc_T45", "arg2_id": "NCT03068897_exc_T47", "normalized": [] }, { "id": "NCT03068897_exc_R17", "type": "Has_temporal", "arg1_id": "NCT03068897_exc_T51", "arg2_id": "NCT03068897_exc_T50", "normalized": [] }, { "id": "NCT03068897_exc_R18", "type": "Subsumes", "arg1_id": "NCT03068897_exc_T53", "arg2_id": "NCT03068897_exc_T56", "normalized": [] }, { "id": "NCT03068897_exc_R19", "type": "AND", "arg1_id": "NCT03068897_exc_T48", "arg2_id": "NCT03068897_exc_T49", "normalized": [] }, { "id": "NCT03068897_exc_R20", "type": "Subsumes", "arg1_id": "NCT03068897_exc_T69", "arg2_id": "NCT03068897_exc_T70", "normalized": [] } ]

[ { "id": "NCT03068897_inc_text", "type": "inclusion", "text": [ "Present to ED primary for management of LBP, defined as pain originating between the lower border of the scapulae and the upper gluteal folds. Flank pain, that is pain originating from tissues lateral to the paraspinal muscles, will not be included.\nMusculoskeletal etiology of low back. Patients with non-musculoskeletal etiologies such as urinary tract infection, ovarian cysts, or influenza like illness will be excluded. The primary clinical diagnosis, at the conclusion of the ED visit, must be a diagnosis consistent with non-traumatic, non-radicular, musculoskeletal LBP.\nPatient is to be discharged home. Patients admitted to the hospital are more likely to be treated with parenteral medication and therefore are not appropriate for this study.\nAge 18-64 Enrollment will be limited to adults younger than 65 years because of the increased risk of adverse medication effects in the elderly.\nNon-radicular pain. Patients will be excluded if the pain radiates below the gluteal folds in a radicular pattern.\nPain duration <2 weeks (336 hours). Patients with more than two weeks of pain are at increased risk of poor pain and functional outcomes.(9)\nPrior to the acute attack of LBP, back pain cannot occur more frequently than once per month. Patients with more frequent back pain are at increased risk of poor pain and functional outcomes.(9)\nNon-traumatic LBP: no substantial and direct trauma to the back within the previous month\nFunctionally impairing back pain: A baseline score of > 5 on the Roland-Morris Disability Questionnaire\n" ], "offsets": [ [ 0, 1544 ] ] } ]

[ { "id": "NCT03068897_inc_T1", "type": "Visit", "text": [ "ED" ], "offsets": [ [ 11, 13 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T2", "type": "Condition", "text": [ "LBP" ], "offsets": [ [ 40, 43 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T3", "type": "Observation", "text": [ "Present" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T4", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 56, 60 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T5", "type": "Qualifier", "text": [ "between the lower border of the scapulae and the upper gluteal folds" ], "offsets": [ [ 73, 141 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T6", "type": "Scope", "text": [ "Present to ED primary for management of LBP" ], "offsets": [ [ 0, 43 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T7", "type": "Scope", "text": [ "pain originating between the lower border of the scapulae and the upper gluteal folds" ], "offsets": [ [ 56, 141 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T8", "type": "Condition", "text": [ "Flank pain" ], "offsets": [ [ 143, 153 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T9", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 163, 167 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T10", "type": "Qualifier", "text": [ "tissues lateral to the paraspinal muscles" ], "offsets": [ [ 185, 226 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T11", "type": "Negation", "text": [ "not" ], "offsets": [ [ 233, 236 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T12", "type": "Condition", "text": [ "urinary tract infection" ], "offsets": [ [ 341, 364 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T13", "type": "Condition", "text": [ "etiology" ], "offsets": [ [ 266, 274 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T14", "type": "Negation", "text": [ "non" ], "offsets": [ [ 302, 305 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T15", "type": "Condition", "text": [ "etiologies" ], "offsets": [ [ 322, 332 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T16", "type": "Qualifier", "text": [ "low back" ], "offsets": [ [ 278, 286 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T17", "type": "Condition", "text": [ "ovarian cysts" ], "offsets": [ [ 366, 379 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T18", "type": "Condition", "text": [ "influenza like illness" ], "offsets": [ [ 384, 406 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T19", "type": "Negation", "text": [ "excluded" ], "offsets": [ [ 415, 423 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T20", "type": "Scope", "text": [ "non-musculoskeletal etiologies" ], "offsets": [ [ 302, 332 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T21", "type": "Scope", "text": [ "urinary tract infection, ovarian cysts, or influenza like illness" ], "offsets": [ [ 341, 406 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T22", "type": "Condition", "text": [ "LBP" ], "offsets": [ [ 574, 577 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T23", "type": "Qualifier", "text": [ "non-radicular" ], "offsets": [ [ 543, 556 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T24", "type": "Qualifier", "text": [ "non-traumatic" ], "offsets": [ [ 528, 541 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T25", "type": "Qualifier", "text": [ "musculoskeletal" ], "offsets": [ [ 558, 573 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T26", "type": "Scope", "text": [ "Musculoskeletal etiology of low back" ], "offsets": [ [ 250, 286 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T27", "type": "Scope", "text": [ "non-traumatic, non-radicular, musculoskeletal LBP" ], "offsets": [ [ 528, 577 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T29", "type": "Person", "text": [ "Age" ], "offsets": [ [ 754, 757 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T30", "type": "Value", "text": [ "18-64" ], "offsets": [ [ 758, 763 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T31", "type": "Person", "text": [ "adults" ], "offsets": [ [ 794, 800 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T32", "type": "Value", "text": [ "younger than 65 years" ], "offsets": [ [ 801, 822 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T33", "type": "Condition", "text": [ "erse me", "ects in" ], "offsets": [ [ 859, 866 ], [ 878, 885 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T34", "type": "Drug", "text": [ "medication" ], "offsets": [ [ 864, 874 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T35", "type": "Person", "text": [ "elderly" ], "offsets": [ [ 890, 897 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T36", "type": "Mood", "text": [ "increased risk" ], "offsets": [ [ 838, 852 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T37", "type": "Negation", "text": [ "Non" ], "offsets": [ [ 899, 902 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T38", "type": "Qualifier", "text": [ "radicular" ], "offsets": [ [ 903, 912 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T39", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 913, 917 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T40", "type": "Qualifier", "text": [ "musculoskeletal" ], "offsets": [ [ 306, 321 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T41", "type": "Qualifier", "text": [ "Musculoskeletal" ], "offsets": [ [ 250, 265 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T42", "type": "Negation", "text": [ "excluded" ], "offsets": [ [ 936, 944 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T43", "type": "Condition", "text": [ "pain" ], "offsets": [ [ 952, 956 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T44", "type": "Qualifier", "text": [ "below the gluteal folds in a radicular pattern" ], "offsets": [ [ 966, 1012 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T45", "type": "Condition", "text": [ "Pain" ], "offsets": [ [ 1014, 1018 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T46", "type": "Temporal", "text": [ "duration <2 weeks" ], "offsets": [ [ 1019, 1036 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T47", "type": "Temporal", "text": [ "ion <2 w", "ours). Pa" ], "offsets": [ [ 1024, 1032 ], [ 1043, 1052 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T48", "type": "Scope", "text": [ "duration <2 weeks (336 hours)" ], "offsets": [ [ 1019, 1048 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T49", "type": "Temporal", "text": [ "acute" ], "offsets": [ [ 1168, 1173 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T50", "type": "Condition", "text": [ "attack of LBP" ], "offsets": [ [ 1174, 1187 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T52", "type": "Negation", "text": [ "cannot" ], "offsets": [ [ 1199, 1205 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T53", "type": "Condition", "text": [ "back pain" ], "offsets": [ [ 1189, 1198 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T54", "type": "Temporal", "text": [ "Prior to the acute attack of LBP" ], "offsets": [ [ 1155, 1187 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T55", "type": "Reference_point", "text": [ "acute attack of LBP" ], "offsets": [ [ 1168, 1187 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T51", "type": "Multiplier", "text": [ "more frequently than once per month" ], "offsets": [ [ 1212, 1247 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T56", "type": "Condition", "text": [ "LBP" ], "offsets": [ [ 1364, 1367 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T57", "type": "Qualifier", "text": [ "Non-traumatic" ], "offsets": [ [ 1350, 1363 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T58", "type": "Qualifier", "text": [ "direct" ], "offsets": [ [ 1388, 1394 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T59", "type": "Qualifier", "text": [ "substantial" ], "offsets": [ [ 1372, 1383 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T60", "type": "Condition", "text": [ "trauma" ], "offsets": [ [ 1395, 1401 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T61", "type": "Scope", "text": [ "substantial and direct" ], "offsets": [ [ 1372, 1394 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T62", "type": "Negation", "text": [ "no" ], "offsets": [ [ 1369, 1371 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T63", "type": "Qualifier", "text": [ "back" ], "offsets": [ [ 1409, 1413 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T64", "type": "Temporal", "text": [ "within the previous month" ], "offsets": [ [ 1414, 1439 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T65", "type": "Scope", "text": [ "no substantial and direct trauma to the back within the previous month" ], "offsets": [ [ 1369, 1439 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T66", "type": "Scope", "text": [ "Non-traumatic LBP" ], "offsets": [ [ 1350, 1367 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T67", "type": "Qualifier", "text": [ "Functionally impairing" ], "offsets": [ [ 1440, 1462 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T68", "type": "Condition", "text": [ "back pain" ], "offsets": [ [ 1463, 1472 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T69", "type": "Measurement", "text": [ "Roland-Morris Disability Questionnaire" ], "offsets": [ [ 1505, 1543 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T70", "type": "Temporal", "text": [ "baseline" ], "offsets": [ [ 1476, 1484 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T71", "type": "Value", "text": [ "score of > 5" ], "offsets": [ [ 1485, 1497 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T72", "type": "Scope", "text": [ "Functionally impairing back pain" ], "offsets": [ [ 1440, 1472 ] ], "normalized": [] }, { "id": "NCT03068897_inc_T73", "type": "Scope", "text": [ "baseline score of > 5 on the Roland-Morris Disability Questionnaire" ], "offsets": [ [ 1476, 1543 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03068897_inc_R1", "type": "AND", "arg1_id": "NCT03068897_inc_T3", "arg2_id": "NCT03068897_inc_T1", "normalized": [] }, { "id": "NCT03068897_inc_R2", "type": "AND", "arg1_id": "NCT03068897_inc_T1", "arg2_id": "NCT03068897_inc_T2", "normalized": [] }, { "id": "NCT03068897_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T4", "arg2_id": "NCT03068897_inc_T5", "normalized": [] }, { "id": "NCT03068897_inc_R4", "type": "Subsumes", "arg1_id": "NCT03068897_inc_T6", "arg2_id": "NCT03068897_inc_T7", "normalized": [] }, { "id": "NCT03068897_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T9", "arg2_id": "NCT03068897_inc_T10", "normalized": [] }, { "id": "NCT03068897_inc_R6", "type": "Subsumes", "arg1_id": "NCT03068897_inc_T8", "arg2_id": "NCT03068897_inc_T9", "normalized": [] }, { "id": "NCT03068897_inc_R7", "type": "Has_negation", "arg1_id": "NCT03068897_inc_T8", "arg2_id": "NCT03068897_inc_T11", "normalized": [] }, { "id": "NCT03068897_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T13", "arg2_id": "NCT03068897_inc_T16", "normalized": [] }, { "id": "NCT03068897_inc_R10", "type": "Subsumes", "arg1_id": "NCT03068897_inc_T20", "arg2_id": "NCT03068897_inc_T21", "normalized": [] }, { "id": "NCT03068897_inc_R11", "type": "Has_negation", "arg1_id": "NCT03068897_inc_T20", "arg2_id": "NCT03068897_inc_T19", "normalized": [] }, { "id": "NCT03068897_inc_R12", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T22", "arg2_id": "NCT03068897_inc_T25", "normalized": [] }, { "id": "NCT03068897_inc_R13", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T22", "arg2_id": "NCT03068897_inc_T23", "normalized": [] }, { "id": "NCT03068897_inc_R14", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T22", "arg2_id": "NCT03068897_inc_T24", "normalized": [] }, { "id": "NCT03068897_inc_R15", "type": "Subsumes", "arg1_id": "NCT03068897_inc_T26", "arg2_id": "NCT03068897_inc_T27", "normalized": [] }, { "id": "NCT03068897_inc_R16", "type": "Has_value", "arg1_id": "NCT03068897_inc_T29", "arg2_id": "NCT03068897_inc_T30", "normalized": [] }, { "id": "NCT03068897_inc_R17", "type": "Has_value", "arg1_id": "NCT03068897_inc_T31", "arg2_id": "NCT03068897_inc_T32", "normalized": [] }, { "id": "NCT03068897_inc_R18", "type": "AND", "arg1_id": "NCT03068897_inc_T33", "arg2_id": "NCT03068897_inc_T34", "normalized": [] }, { "id": "NCT03068897_inc_R19", "type": "Has_mood", "arg1_id": "NCT03068897_inc_T33", "arg2_id": "NCT03068897_inc_T36", "normalized": [] }, { "id": "NCT03068897_inc_R9", "type": "Has_negation", "arg1_id": "NCT03068897_inc_T40", "arg2_id": "NCT03068897_inc_T14", "normalized": [] }, { "id": "NCT03068897_inc_R20", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T15", "arg2_id": "NCT03068897_inc_T40", "normalized": [] }, { "id": "NCT03068897_inc_R21", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T13", "arg2_id": "NCT03068897_inc_T41", "normalized": [] }, { "id": "NCT03068897_inc_R22", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T39", "arg2_id": "NCT03068897_inc_T38", "normalized": [] }, { "id": "NCT03068897_inc_R23", "type": "Has_negation", "arg1_id": "NCT03068897_inc_T38", "arg2_id": "NCT03068897_inc_T37", "normalized": [] }, { "id": "NCT03068897_inc_R24", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T43", "arg2_id": "NCT03068897_inc_T44", "normalized": [] }, { "id": "NCT03068897_inc_R25", "type": "Has_negation", "arg1_id": "NCT03068897_inc_T43", "arg2_id": "NCT03068897_inc_T42", "normalized": [] }, { "id": "NCT03068897_inc_R26", "type": "Has_scope", "arg1_id": "NCT03068897_inc_T45", "arg2_id": "NCT03068897_inc_T48", "normalized": [] }, { "id": "NCT03068897_inc_R27", "type": "Has_temporal", "arg1_id": "NCT03068897_inc_T50", "arg2_id": "NCT03068897_inc_T49", "normalized": [] }, { "id": "NCT03068897_inc_R28", "type": "Has_index", "arg1_id": "NCT03068897_inc_T54", "arg2_id": "NCT03068897_inc_T55", "normalized": [] }, { "id": "NCT03068897_inc_R30", "type": "Has_negation", "arg1_id": "NCT03068897_inc_T51", "arg2_id": "NCT03068897_inc_T52", "normalized": [] }, { "id": "NCT03068897_inc_R31", "type": "Has_multiplier", "arg1_id": "NCT03068897_inc_T53", "arg2_id": "NCT03068897_inc_T51", "normalized": [] }, { "id": "NCT03068897_inc_R32", "type": "Has_temporal", "arg1_id": "NCT03068897_inc_T53", "arg2_id": "NCT03068897_inc_T54", "normalized": [] }, { "id": "NCT03068897_inc_R33", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T56", "arg2_id": "NCT03068897_inc_T57", "normalized": [] }, { "id": "NCT03068897_inc_R34", "type": "Has_scope", "arg1_id": "NCT03068897_inc_T60", "arg2_id": "NCT03068897_inc_T61", "normalized": [] }, { "id": "NCT03068897_inc_R35", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T60", "arg2_id": "NCT03068897_inc_T63", "normalized": [] }, { "id": "NCT03068897_inc_R36", "type": "Has_temporal", "arg1_id": "NCT03068897_inc_T60", "arg2_id": "NCT03068897_inc_T64", "normalized": [] }, { "id": "NCT03068897_inc_R37", "type": "Subsumes", "arg1_id": "NCT03068897_inc_T66", "arg2_id": "NCT03068897_inc_T65", "normalized": [] }, { "id": "NCT03068897_inc_R38", "type": "Has_value", "arg1_id": "NCT03068897_inc_T69", "arg2_id": "NCT03068897_inc_T71", "normalized": [] }, { "id": "NCT03068897_inc_R39", "type": "Has_temporal", "arg1_id": "NCT03068897_inc_T69", "arg2_id": "NCT03068897_inc_T70", "normalized": [] }, { "id": "NCT03068897_inc_R40", "type": "Has_qualifier", "arg1_id": "NCT03068897_inc_T68", "arg2_id": "NCT03068897_inc_T67", "normalized": [] }, { "id": "NCT03068897_inc_R41", "type": "Subsumes", "arg1_id": "NCT03068897_inc_T72", "arg2_id": "NCT03068897_inc_T73", "normalized": [] } ]

[ { "id": "NCT03070847_exc_text", "type": "exclusion", "text": [ "pregnancy\nknown allergies for tranexamic acid or any other substance in Exacyl\ndeep vein thrombosis\nHormone Replacement Therapy or oral contraceptive usage\nanticoagulants usage\nobesity - BMI (body mass index) >30 kg/m2\nrenal disease, as glomerular filtration rate (GFR) <60 ml/min/1,73 m*m\nseizures or epilepsy in the past\n" ], "offsets": [ [ 0, 323 ] ] } ]

[ { "id": "NCT03070847_exc_T1", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T2", "type": "Condition", "text": [ "allergies" ], "offsets": [ [ 16, 25 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T3", "type": "Drug", "text": [ "tranexamic acid" ], "offsets": [ [ 30, 45 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T4", "type": "Drug", "text": [ "Exacyl" ], "offsets": [ [ 72, 78 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T5", "type": "Scope", "text": [ "tranexamic acid or any other substance in Exacyl" ], "offsets": [ [ 30, 78 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T6", "type": "Condition", "text": [ "deep vein thrombosis" ], "offsets": [ [ 79, 99 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T7", "type": "Procedure", "text": [ "Hormone Replacement Therapy" ], "offsets": [ [ 100, 127 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T8", "type": "Drug", "text": [ "oral contraceptive" ], "offsets": [ [ 131, 149 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T9", "type": "Drug", "text": [ "anticoagulants" ], "offsets": [ [ 156, 170 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T10", "type": "Condition", "text": [ "obesity" ], "offsets": [ [ 177, 184 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T11", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 187, 190 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T12", "type": "Measurement", "text": [ "body mass index" ], "offsets": [ [ 192, 207 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T13", "type": "Value", "text": [ ">30 kg/m2" ], "offsets": [ [ 209, 218 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T14", "type": "Scope", "text": [ "BMI (body mass index) >30 kg/m2" ], "offsets": [ [ 187, 218 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T15", "type": "Condition", "text": [ "renal disease" ], "offsets": [ [ 219, 232 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T16", "type": "Measurement", "text": [ "glomerular filtration rate" ], "offsets": [ [ 237, 263 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T17", "type": "Measurement", "text": [ "GFR" ], "offsets": [ [ 265, 268 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T18", "type": "Value", "text": [ "<60 ml/min/1,73 m*m" ], "offsets": [ [ 270, 289 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T19", "type": "Value", "text": [ "seizures" ], "offsets": [ [ 290, 298 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T20", "type": "Value", "text": [ "epilepsy" ], "offsets": [ [ 302, 310 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T21", "type": "Temporal", "text": [ "in the past" ], "offsets": [ [ 311, 322 ] ], "normalized": [] }, { "id": "NCT03070847_exc_T22", "type": "Scope", "text": [ "seizures or epilepsy" ], "offsets": [ [ 290, 310 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03070847_exc_R1", "type": "Has_scope", "arg1_id": "NCT03070847_exc_T2", "arg2_id": "NCT03070847_exc_T5", "normalized": [] }, { "id": "NCT03070847_exc_R2", "type": "Subsumes", "arg1_id": "NCT03070847_exc_T11", "arg2_id": "NCT03070847_exc_T12", "normalized": [] }, { "id": "NCT03070847_exc_R3", "type": "Has_value", "arg1_id": "NCT03070847_exc_T11", "arg2_id": "NCT03070847_exc_T13", "normalized": [] }, { "id": "NCT03070847_exc_R4", "type": "Subsumes", "arg1_id": "NCT03070847_exc_T10", "arg2_id": "NCT03070847_exc_T14", "normalized": [] }, { "id": "NCT03070847_exc_R5", "type": "Subsumes", "arg1_id": "NCT03070847_exc_T16", "arg2_id": "NCT03070847_exc_T17", "normalized": [] }, { "id": "NCT03070847_exc_R6", "type": "Has_value", "arg1_id": "NCT03070847_exc_T16", "arg2_id": "NCT03070847_exc_T18", "normalized": [] }, { "id": "NCT03070847_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03070847_exc_T22", "arg2_id": "NCT03070847_exc_T21", "normalized": [] } ]

[ { "id": "NCT03070847_inc_text", "type": "inclusion", "text": [ "age > 18 y.o.\nAmerican Society of Anesthesiologists Physical Status Classification (ASA) 1-2\nsigned informed consent form after reading the information about the study and talking with one of the investigators\n" ], "offsets": [ [ 0, 210 ] ] } ]

[ { "id": "NCT03070847_inc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03070847_inc_T2", "type": "Value", "text": [ "> 18 y.o" ], "offsets": [ [ 4, 12 ] ], "normalized": [] }, { "id": "NCT03070847_inc_T3", "type": "Measurement", "text": [ "American Society of Anesthesiologists Physical Status Classification" ], "offsets": [ [ 14, 82 ] ], "normalized": [] }, { "id": "NCT03070847_inc_T4", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 84, 87 ] ], "normalized": [] }, { "id": "NCT03070847_inc_T5", "type": "Value", "text": [ "1-2" ], "offsets": [ [ 89, 92 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03070847_inc_R1", "type": "Has_value", "arg1_id": "NCT03070847_inc_T1", "arg2_id": "NCT03070847_inc_T2", "normalized": [] }, { "id": "NCT03070847_inc_R2", "type": "Subsumes", "arg1_id": "NCT03070847_inc_T3", "arg2_id": "NCT03070847_inc_T4", "normalized": [] }, { "id": "NCT03070847_inc_R3", "type": "Has_value", "arg1_id": "NCT03070847_inc_T3", "arg2_id": "NCT03070847_inc_T5", "normalized": [] } ]

[ { "id": "NCT03073603_exc_text", "type": "exclusion", "text": [ "Any MS relapse in the last five years, as determined at the screen visit by the PI\nAny new or definitely enlarging T2/FLAIR lesion or new gadolinium-enhancing lesion within the past three years (at least two scans separated by at least three years must be reviewed) on brain or spine MRI scan. Lesions must be 3mm or larger to be exclusionary.\nSignificant (as defined by the PI) intolerance of presently-used DMT\nUse of inhaled or topical steroids are not an exclusion criteria.\nUse of oral steroids for no greater than 14 days given for a non-MS condition is not exclusionary.\nalemtuzumab,\nmitoxantrone,\ncyclophosphamide,\nmethotrexate,\ncyclosporine, or\nrituximab\nPrior use of any experimental agent used as a DMT for MS in the last five years\nuncontrolled hypertension,\nuncontrolled diabetes,\nuncontrolled asthma, or\nuncontrolled depression\nCancers other than basal cell skin cancers within the last 5 years\nUnable to give informed consent or follow the protocol\nUnable to undergo brain MRI\nUnwilling to be randomized per this protocol\nHistory of other chronic neurological illnesses that might mimic MS with chronic or intermittent symptoms (i.e. ALS, myasthenia gravis, chronic neuropathy, etc.)\n" ], "offsets": [ [ 0, 1199 ] ] } ]

[ { "id": "NCT03073603_exc_T1", "type": "Condition", "text": [ "MS" ], "offsets": [ [ 4, 6 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T2", "type": "Condition", "text": [ "relapse" ], "offsets": [ [ 7, 14 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T3", "type": "Temporal", "text": [ "in the last five years" ], "offsets": [ [ 15, 37 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T4", "type": "Condition", "text": [ "T2/FLAIR lesion" ], "offsets": [ [ 115, 130 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T5", "type": "Drug", "text": [ "gadolinium" ], "offsets": [ [ 138, 148 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T6", "type": "Qualifier", "text": [ "gadolinium-enhancing" ], "offsets": [ [ 138, 158 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T7", "type": "Condition", "text": [ "lesion" ], "offsets": [ [ 159, 165 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T8", "type": "Temporal", "text": [ "within the past three years" ], "offsets": [ [ 166, 193 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T9", "type": "Multiplier", "text": [ "at least two" ], "offsets": [ [ 195, 207 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T10", "type": "Procedure", "text": [ "scans" ], "offsets": [ [ 208, 213 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T11", "type": "Temporal", "text": [ "separated by at least three years" ], "offsets": [ [ 214, 247 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T12", "type": "Procedure", "text": [ "spine MRI scan" ], "offsets": [ [ 278, 292 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T13", "type": "Procedure", "text": [ "rain", "RI scan." ], "offsets": [ [ 270, 274 ], [ 285, 293 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T14", "type": "Qualifier", "text": [ "3mm or larger" ], "offsets": [ [ 310, 323 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T15", "type": "Condition", "text": [ "Lesions" ], "offsets": [ [ 294, 301 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T16", "type": "Scope", "text": [ "T2/FLAIR lesion or new gadolinium-enhancing lesion" ], "offsets": [ [ 115, 165 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T17", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 344, 355 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T18", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 379, 390 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T19", "type": "Temporal", "text": [ "presently-used" ], "offsets": [ [ 394, 408 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T20", "type": "Drug", "text": [ "DMT" ], "offsets": [ [ 409, 412 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T21", "type": "Drug", "text": [ "aled or", "roids ar" ], "offsets": [ [ 423, 430 ], [ 442, 450 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T22", "type": "Drug", "text": [ "topical steroids" ], "offsets": [ [ 431, 447 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T23", "type": "Negation", "text": [ "not" ], "offsets": [ [ 452, 455 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T24", "type": "Scope", "text": [ "inhaled or topical steroids" ], "offsets": [ [ 420, 447 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T26", "type": "Drug", "text": [ "oral steroids" ], "offsets": [ [ 486, 499 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T27", "type": "Temporal", "text": [ "no greater than 14 days" ], "offsets": [ [ 504, 527 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T28", "type": "Condition", "text": [ "non-MS condition" ], "offsets": [ [ 540, 556 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T29", "type": "Negation", "text": [ "not" ], "offsets": [ [ 560, 563 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T31", "type": "Drug", "text": [ "alemtuzumab" ], "offsets": [ [ 578, 589 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T32", "type": "Drug", "text": [ "mitoxantrone" ], "offsets": [ [ 591, 603 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T33", "type": "Drug", "text": [ "cyclophosphamide" ], "offsets": [ [ 605, 621 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T34", "type": "Drug", "text": [ "methotrexate" ], "offsets": [ [ 623, 635 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T35", "type": "Drug", "text": [ "cyclosporine" ], "offsets": [ [ 637, 649 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T36", "type": "Drug", "text": [ "rituximab" ], "offsets": [ [ 654, 663 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T38", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 757, 769 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T39", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 784, 792 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T40", "type": "Condition", "text": [ "asthma" ], "offsets": [ [ 807, 813 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T41", "type": "Condition", "text": [ "depression" ], "offsets": [ [ 831, 841 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T42", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 744, 756 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T43", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 794, 806 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T44", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 818, 830 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T45", "type": "Qualifier", "text": [ "uncontrolled" ], "offsets": [ [ 818, 830 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T46", "type": "Condition", "text": [ "Cancers" ], "offsets": [ [ 842, 849 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T47", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 850, 860 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T48", "type": "Condition", "text": [ "basal cell skin cancers" ], "offsets": [ [ 861, 884 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T49", "type": "Temporal", "text": [ "within the last 5 years" ], "offsets": [ [ 885, 908 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T51", "type": "Procedure", "text": [ "brain MRI" ], "offsets": [ [ 982, 991 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T52", "type": "Mood", "text": [ "Unable to undergo" ], "offsets": [ [ 964, 981 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T54", "type": "Condition", "text": [ "chronic neurological illnesses" ], "offsets": [ [ 1054, 1084 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T55", "type": "Observation", "text": [ "History of" ], "offsets": [ [ 1037, 1047 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T56", "type": "Qualifier", "text": [ "mimic MS" ], "offsets": [ [ 1096, 1104 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T57", "type": "Condition", "text": [ "ALS" ], "offsets": [ [ 1149, 1152 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T58", "type": "Condition", "text": [ "myasthenia gravis" ], "offsets": [ [ 1154, 1171 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T59", "type": "Condition", "text": [ "chronic neuropathy" ], "offsets": [ [ 1173, 1191 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T60", "type": "Scope", "text": [ "ALS, myasthenia gravis, chronic neuropathy" ], "offsets": [ [ 1149, 1191 ] ], "normalized": [] }, { "id": "NCT03073603_exc_T61", "type": "Scope", "text": [ "chronic neurological illnesses that might mimic MS" ], "offsets": [ [ 1054, 1104 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03073603_exc_R1", "type": "AND", "arg1_id": "NCT03073603_exc_T2", "arg2_id": "NCT03073603_exc_T1", "normalized": [] }, { "id": "NCT03073603_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03073603_exc_T2", "arg2_id": "NCT03073603_exc_T3", "normalized": [] }, { "id": "NCT03073603_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03073603_exc_T7", "arg2_id": "NCT03073603_exc_T6", "normalized": [] }, { "id": "NCT03073603_exc_R4", "type": "Has_multiplier", "arg1_id": "NCT03073603_exc_T10", "arg2_id": "NCT03073603_exc_T9", "normalized": [] }, { "id": "NCT03073603_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03073603_exc_T10", "arg2_id": "NCT03073603_exc_T11", "normalized": [] }, { "id": "NCT03073603_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03073603_exc_T15", "arg2_id": "NCT03073603_exc_T14", "normalized": [] }, { "id": "NCT03073603_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03073603_exc_T16", "arg2_id": "NCT03073603_exc_T8", "normalized": [] }, { "id": "NCT03073603_exc_R10", "type": "AND", "arg1_id": "NCT03073603_exc_T16", "arg2_id": "NCT03073603_exc_T10", "normalized": [] }, { "id": "NCT03073603_exc_R7", "type": "Subsumes", "arg1_id": "NCT03073603_exc_T16", "arg2_id": "NCT03073603_exc_T15", "normalized": [] }, { "id": "NCT03073603_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03073603_exc_T16", "arg2_id": "NCT03073603_exc_T14", "normalized": [] }, { "id": "NCT03073603_exc_R11", "type": "Has_temporal", "arg1_id": "NCT03073603_exc_T20", "arg2_id": "NCT03073603_exc_T19", "normalized": [] }, { "id": "NCT03073603_exc_R12", "type": "AND", "arg1_id": "NCT03073603_exc_T18", "arg2_id": "NCT03073603_exc_T20", "normalized": [] }, { "id": "NCT03073603_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT03073603_exc_T18", "arg2_id": "NCT03073603_exc_T17", "normalized": [] }, { "id": "NCT03073603_exc_R14", "type": "Has_scope", "arg1_id": "NCT03073603_exc_T23", "arg2_id": "NCT03073603_exc_T24", "normalized": [] }, { "id": "NCT03073603_exc_R15", "type": "Has_temporal", "arg1_id": "NCT03073603_exc_T26", "arg2_id": "NCT03073603_exc_T27", "normalized": [] }, { "id": "NCT03073603_exc_R16", "type": "AND", "arg1_id": "NCT03073603_exc_T26", "arg2_id": "NCT03073603_exc_T28", "normalized": [] }, { "id": "NCT03073603_exc_R17", "type": "Has_negation", "arg1_id": "NCT03073603_exc_T26", "arg2_id": "NCT03073603_exc_T29", "normalized": [] }, { "id": "NCT03073603_exc_R18", "type": "Has_qualifier", "arg1_id": "NCT03073603_exc_T38", "arg2_id": "NCT03073603_exc_T42", "normalized": [] }, { "id": "NCT03073603_exc_R19", "type": "Has_qualifier", "arg1_id": "NCT03073603_exc_T39", "arg2_id": "NCT03073603_exc_T43", "normalized": [] }, { "id": "NCT03073603_exc_R20", "type": "Has_qualifier", "arg1_id": "NCT03073603_exc_T40", "arg2_id": "NCT03073603_exc_T44", "normalized": [] }, { "id": "NCT03073603_exc_R21", "type": "Has_qualifier", "arg1_id": "NCT03073603_exc_T41", "arg2_id": "NCT03073603_exc_T45", "normalized": [] }, { "id": "NCT03073603_exc_R22", "type": "Has_temporal", "arg1_id": "NCT03073603_exc_T48", "arg2_id": "NCT03073603_exc_T49", "normalized": [] }, { "id": "NCT03073603_exc_R23", "type": "Has_negation", "arg1_id": "NCT03073603_exc_T48", "arg2_id": "NCT03073603_exc_T47", "normalized": [] }, { "id": "NCT03073603_exc_R24", "type": "AND", "arg1_id": "NCT03073603_exc_T46", "arg2_id": "NCT03073603_exc_T48", "normalized": [] }, { "id": "NCT03073603_exc_R25", "type": "Has_mood", "arg1_id": "NCT03073603_exc_T51", "arg2_id": "NCT03073603_exc_T52", "normalized": [] }, { "id": "NCT03073603_exc_R26", "type": "Has_qualifier", "arg1_id": "NCT03073603_exc_T54", "arg2_id": "NCT03073603_exc_T56", "normalized": [] }, { "id": "NCT03073603_exc_R27", "type": "Subsumes", "arg1_id": "NCT03073603_exc_T61", "arg2_id": "NCT03073603_exc_T60", "normalized": [] }, { "id": "NCT03073603_exc_R28", "type": "Has_temporal", "arg1_id": "NCT03073603_exc_T61", "arg2_id": "NCT03073603_exc_T55", "normalized": [] } ]

[ { "id": "NCT03073603_inc_text", "type": "inclusion", "text": [ "Patients with either Relapsing-remitting MS (RRMS), Secondary progressive MS (SPMS), or Primary progressive MS (PPMS) by McDonald 2010 criteria.\nPatients defined by subtype based on 2013 updated phenotypic criteria.\nprospectively with an EDSS change of at least 1.0 points over the last two years, or\nretrospectively, with any significant change in motor function over at least one year, unrelated to relapse.\n55 years of age or older at time of randomization;\nNo evidence of recent new inflammatory disease activity (inactive by the Lublin criteria16) with no new relapse for at least five years and no new MRI lesion for at least three years\ninterferon ß-1a,\ninterferon ß-1b,\nglatiramer acetate,\nnatalizumab,\nfingolimod,\ndimethyl fumarate, or\nteriflunomide; continuously for no less than 5 years.\nTaking most recent DMT continuously* for no less than two years.\nWilling to be randomized per this protocol; each patient will be questioned as to their willingness to stay in the trial regardless of the group to which group they are randomized.\nWilling to follow the protocol\nContinuously will be defined as no less than 75% of all prescribed doses, with no time of greater than four weeks from last intended dose to have missed a dose (8 weeks for natalizumab, i.e. one missed dose).\n" ], "offsets": [ [ 0, 1285 ] ] } ]

[ { "id": "NCT03073603_inc_T1", "type": "Condition", "text": [ "Relapsing-remitting MS (RRMS)" ], "offsets": [ [ 21, 50 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T2", "type": "Condition", "text": [ "Secondary progressive MS (SPMS)" ], "offsets": [ [ 52, 83 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T3", "type": "Condition", "text": [ "Primary progressive MS (PPMS)" ], "offsets": [ [ 88, 117 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T5", "type": "Condition", "text": [ "EDSS change" ], "offsets": [ [ 238, 249 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T6", "type": "Value", "text": [ "at least 1.0 points" ], "offsets": [ [ 253, 272 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T7", "type": "Temporal", "text": [ "over the last two years" ], "offsets": [ [ 273, 296 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T8", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 327, 338 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T9", "type": "Condition", "text": [ "change in motor function" ], "offsets": [ [ 339, 363 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T10", "type": "Temporal", "text": [ "over at least one year" ], "offsets": [ [ 364, 386 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T11", "type": "Qualifier", "text": [ "unrelated to relapse" ], "offsets": [ [ 388, 408 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T12", "type": "Value", "text": [ "ears of", "lder at" ], "offsets": [ [ 414, 421 ], [ 430, 437 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T13", "type": "Person", "text": [ "age" ], "offsets": [ [ 422, 425 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T14", "type": "Temporal", "text": [ "at time of randomization" ], "offsets": [ [ 435, 459 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T15", "type": "Condition", "text": [ "inflammatory disease" ], "offsets": [ [ 487, 507 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T16", "type": "Measurement", "text": [ "Lublin criteria" ], "offsets": [ [ 534, 549 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T17", "type": "Value", "text": [ "inactive" ], "offsets": [ [ 518, 526 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T18", "type": "Qualifier", "text": [ "new" ], "offsets": [ [ 483, 486 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T19", "type": "Negation", "text": [ "No" ], "offsets": [ [ 461, 463 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T20", "type": "Condition", "text": [ "relapse" ], "offsets": [ [ 565, 572 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T21", "type": "Qualifier", "text": [ "new" ], "offsets": [ [ 561, 564 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T22", "type": "Negation", "text": [ "no" ], "offsets": [ [ 558, 560 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T23", "type": "Temporal", "text": [ "for at least five years" ], "offsets": [ [ 573, 596 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T24", "type": "Condition", "text": [ "lesion" ], "offsets": [ [ 612, 618 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T25", "type": "Procedure", "text": [ "MRI" ], "offsets": [ [ 608, 611 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T26", "type": "Temporal", "text": [ "for at least three years" ], "offsets": [ [ 619, 643 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T27", "type": "Negation", "text": [ "no" ], "offsets": [ [ 601, 603 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T28", "type": "Qualifier", "text": [ "new" ], "offsets": [ [ 604, 607 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T29", "type": "Drug", "text": [ "interferon ß-1a" ], "offsets": [ [ 644, 659 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T30", "type": "Drug", "text": [ "interferon ß-1b" ], "offsets": [ [ 661, 676 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T31", "type": "Drug", "text": [ "glatiramer acetate" ], "offsets": [ [ 678, 696 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T32", "type": "Drug", "text": [ "natalizumab" ], "offsets": [ [ 698, 709 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T33", "type": "Drug", "text": [ "fingolimod" ], "offsets": [ [ 711, 721 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T34", "type": "Drug", "text": [ "dimethyl fumarate" ], "offsets": [ [ 723, 740 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T35", "type": "Drug", "text": [ "teriflunomide" ], "offsets": [ [ 745, 758 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T36", "type": "Temporal", "text": [ "for no less than 5 years" ], "offsets": [ [ 773, 797 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T37", "type": "Multiplier", "text": [ "continuously" ], "offsets": [ [ 760, 772 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T38", "type": "Drug", "text": [ "DMT" ], "offsets": [ [ 818, 821 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T39", "type": "Multiplier", "text": [ "continuously" ], "offsets": [ [ 822, 834 ] ], "normalized": [] }, { "id": "NCT03073603_inc_T40", "type": "Temporal", "text": [ "for no less than two years" ], "offsets": [ [ 836, 862 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03073603_inc_R1", "type": "Has_value", "arg1_id": "NCT03073603_inc_T5", "arg2_id": "NCT03073603_inc_T6", "normalized": [] }, { "id": "NCT03073603_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03073603_inc_T5", "arg2_id": "NCT03073603_inc_T7", "normalized": [] }, { "id": "NCT03073603_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03073603_inc_T9", "arg2_id": "NCT03073603_inc_T8", "normalized": [] }, { "id": "NCT03073603_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03073603_inc_T9", "arg2_id": "NCT03073603_inc_T11", "normalized": [] }, { "id": "NCT03073603_inc_R5", "type": "Has_temporal", "arg1_id": "NCT03073603_inc_T9", "arg2_id": "NCT03073603_inc_T10", "normalized": [] }, { "id": "NCT03073603_inc_R6", "type": "Has_value", "arg1_id": "NCT03073603_inc_T13", "arg2_id": "NCT03073603_inc_T12", "normalized": [] }, { "id": "NCT03073603_inc_R7", "type": "Has_temporal", "arg1_id": "NCT03073603_inc_T13", "arg2_id": "NCT03073603_inc_T14", "normalized": [] }, { "id": "NCT03073603_inc_R8", "type": "Has_value", "arg1_id": "NCT03073603_inc_T16", "arg2_id": "NCT03073603_inc_T17", "normalized": [] }, { "id": "NCT03073603_inc_R9", "type": "AND", "arg1_id": "NCT03073603_inc_T15", "arg2_id": "NCT03073603_inc_T16", "normalized": [] }, { "id": "NCT03073603_inc_R10", "type": "Has_qualifier", "arg1_id": "NCT03073603_inc_T15", "arg2_id": "NCT03073603_inc_T18", "normalized": [] }, { "id": "NCT03073603_inc_R11", "type": "Has_negation", "arg1_id": "NCT03073603_inc_T15", "arg2_id": "NCT03073603_inc_T19", "normalized": [] }, { "id": "NCT03073603_inc_R12", "type": "Has_qualifier", "arg1_id": "NCT03073603_inc_T20", "arg2_id": "NCT03073603_inc_T21", "normalized": [] }, { "id": "NCT03073603_inc_R13", "type": "Has_negation", "arg1_id": "NCT03073603_inc_T20", "arg2_id": "NCT03073603_inc_T22", "normalized": [] }, { "id": "NCT03073603_inc_R14", "type": "Has_temporal", "arg1_id": "NCT03073603_inc_T24", "arg2_id": "NCT03073603_inc_T26", "normalized": [] }, { "id": "NCT03073603_inc_R15", "type": "AND", "arg1_id": "NCT03073603_inc_T25", "arg2_id": "NCT03073603_inc_T24", "normalized": [] }, { "id": "NCT03073603_inc_R16", "type": "Has_temporal", "arg1_id": "NCT03073603_inc_T20", "arg2_id": "NCT03073603_inc_T23", "normalized": [] }, { "id": "NCT03073603_inc_R17", "type": "Has_qualifier", "arg1_id": "NCT03073603_inc_T24", "arg2_id": "NCT03073603_inc_T28", "normalized": [] }, { "id": "NCT03073603_inc_R18", "type": "Has_negation", "arg1_id": "NCT03073603_inc_T24", "arg2_id": "NCT03073603_inc_T27", "normalized": [] }, { "id": "NCT03073603_inc_R19", "type": "Has_multiplier", "arg1_id": "NCT03073603_inc_T35", "arg2_id": "NCT03073603_inc_T37", "normalized": [] }, { "id": "NCT03073603_inc_R20", "type": "Has_temporal", "arg1_id": "NCT03073603_inc_T35", "arg2_id": "NCT03073603_inc_T36", "normalized": [] }, { "id": "NCT03073603_inc_R21", "type": "Has_temporal", "arg1_id": "NCT03073603_inc_T38", "arg2_id": "NCT03073603_inc_T40", "normalized": [] }, { "id": "NCT03073603_inc_R22", "type": "Has_multiplier", "arg1_id": "NCT03073603_inc_T38", "arg2_id": "NCT03073603_inc_T39", "normalized": [] } ]

[ { "id": "NCT03077204_exc_text", "type": "exclusion", "text": [ "NA\n" ], "offsets": [ [ 0, 3 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT03077204_inc_text", "type": "inclusion", "text": [ "Age>18 years\nScheduled 1 or 2-level ACDF spine surgery\nThe capacity to provide informed consent.\nDegenerative Disc Disease (as defined by neck pain of discogenic origin with degeneration of the disc confirmed by patient history and radiographic studies)\nTrauma (including fractures)\nTumors\nDeformities or curvatures (including kyphosis, lordosis, or scoliosis)\nPseudoarthrosis\nFailed previous fusion\nDecompression of the spinal cord following total or partial cervical vertebrectomy\nSpondylolisthesis\nSpinal stenosis\nPatients with current or recent history of malignancy or infectious disease.\nThe inability to provide informed consent.\nSubject has marked local inflammation\nSubject has any mental or neuromuscular disorder which would create an unacceptable risk of fixation failure or complications in postoperative care.\nSubject has a bone stock compromised by disease, infection or prior implantation which cannot provide adequate support and/or fixation to the devices.\nSubject has bone abnormalities preventing safe screw fixation.\nSubject has any open wounds.\nSubject has rapid joint disease, bone absorption, osteopenia, osteomalacia, and/or osteoporosis. Osteoporosis or osteopenia are relative contraindications, since this condition may limit the degree of obtainable correction and/or the amount of mechanical fixation.\nSubject has a documented or suspected metal sensitivity.\nSubject is pregnant.\nSubject has anatomical structures or physiological performance that would interfere with implant utilization.\nSubject has inadequate tissue coverage over the operative site.\nSubject has other medical or surgical conditions which would preclude the potential benefit of surgery, such as congenital abnormalities, immunosuppressive disease, elevation of sedimentation rate unexplained by other diseases, elevation of white blood count (WBC), or marked left shift in the WBC differential count.\nNote: The Aviator Anterior Cervical Plating System is not approved or intended for screw attachment to the posterior elements (pedicles) of the cervical, thoracic, or lumbar spine. The surgeon must consider the levels of implantation, patient weight, patient activity level, and other patient conditions which may impact on the performance of the system.\n" ], "offsets": [ [ 0, 2257 ] ] } ]

[ { "id": "NCT03077204_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T2", "type": "Value", "text": [ ">18 years" ], "offsets": [ [ 3, 12 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T3", "type": "Qualifier", "text": [ "2-level" ], "offsets": [ [ 28, 35 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T4", "type": "Qualifier", "text": [ "", "level" ], "offsets": [ [ 24, 24 ], [ 30, 35 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T5", "type": "Procedure", "text": [ "ACDF spine surgery" ], "offsets": [ [ 36, 54 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T6", "type": "Scope", "text": [ "1 or 2-level" ], "offsets": [ [ 23, 35 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T8", "type": "Condition", "text": [ "Degenerative Disc Disease" ], "offsets": [ [ 97, 122 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T9", "type": "Condition", "text": [ "neck pain" ], "offsets": [ [ 138, 147 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T10", "type": "Qualifier", "text": [ "discogenic origin" ], "offsets": [ [ 151, 168 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T11", "type": "Condition", "text": [ "degeneration of the disc" ], "offsets": [ [ 174, 198 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T12", "type": "Observation", "text": [ "patient history" ], "offsets": [ [ 212, 227 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T13", "type": "Procedure", "text": [ "radiographic studies" ], "offsets": [ [ 232, 252 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T14", "type": "Condition", "text": [ "Trauma" ], "offsets": [ [ 254, 260 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T15", "type": "Condition", "text": [ "fractures" ], "offsets": [ [ 272, 281 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T16", "type": "Condition", "text": [ "Tumors" ], "offsets": [ [ 283, 289 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T17", "type": "Condition", "text": [ "Deformities" ], "offsets": [ [ 290, 301 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T18", "type": "Condition", "text": [ "curvatures" ], "offsets": [ [ 305, 315 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T19", "type": "Condition", "text": [ "kyphosis" ], "offsets": [ [ 327, 335 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T20", "type": "Condition", "text": [ "lordosis" ], "offsets": [ [ 337, 345 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T21", "type": "Condition", "text": [ "scoliosis" ], "offsets": [ [ 350, 359 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T22", "type": "Scope", "text": [ "kyphosis, lordosis, or scoliosis" ], "offsets": [ [ 327, 359 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T23", "type": "Scope", "text": [ "Deformities or curvatures" ], "offsets": [ [ 290, 315 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T24", "type": "Condition", "text": [ "Pseudoarthrosis" ], "offsets": [ [ 361, 376 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T25", "type": "Procedure", "text": [ "fusion" ], "offsets": [ [ 393, 399 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T26", "type": "Qualifier", "text": [ "Failed" ], "offsets": [ [ 377, 383 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T27", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 384, 392 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T28", "type": "Procedure", "text": [ "Decompression of the spinal cord" ], "offsets": [ [ 400, 432 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T29", "type": "Procedure", "text": [ "partial cervical vertebrectomy" ], "offsets": [ [ 452, 482 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T30", "type": "Procedure", "text": [ "parti", "vertebrectomy\nSpondylo" ], "offsets": [ [ 452, 457 ], [ 469, 491 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T31", "type": "Scope", "text": [ "total or partial cervical vertebrectomy" ], "offsets": [ [ 443, 482 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T32", "type": "Condition", "text": [ "Spondylolisthesis" ], "offsets": [ [ 483, 500 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T34", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 542, 548 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T35", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 531, 538 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T36", "type": "Observation", "text": [ "history" ], "offsets": [ [ 549, 556 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T37", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 560, 570 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T38", "type": "Condition", "text": [ "infectious disease" ], "offsets": [ [ 574, 592 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T33", "type": "Condition", "text": [ "Spinal stenosis" ], "offsets": [ [ 501, 516 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T40", "type": "Condition", "text": [ "local inflammation" ], "offsets": [ [ 656, 674 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T41", "type": "Qualifier", "text": [ "marked" ], "offsets": [ [ 649, 655 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T42", "type": "Condition", "text": [ "muscul", "would cr" ], "offsets": [ [ 706, 712 ], [ 730, 738 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T43", "type": "Condition", "text": [ "neuromuscular disorder" ], "offsets": [ [ 701, 723 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T44", "type": "Condition", "text": [ "fixation failure" ], "offsets": [ [ 767, 783 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T45", "type": "Qualifier", "text": [ "unacceptable" ], "offsets": [ [ 746, 758 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T46", "type": "Condition", "text": [ "complications" ], "offsets": [ [ 787, 800 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T47", "type": "Mood", "text": [ "risk of" ], "offsets": [ [ 759, 766 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T48", "type": "Scope", "text": [ "fixation failure or complications" ], "offsets": [ [ 767, 800 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T49", "type": "Scope", "text": [ "mental or neuromuscular disorder" ], "offsets": [ [ 691, 723 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T50", "type": "Condition", "text": [ "bone stock compromised" ], "offsets": [ [ 838, 860 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T51", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 864, 871 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T52", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 873, 882 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T53", "type": "Procedure", "text": [ "implantation" ], "offsets": [ [ 892, 904 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T54", "type": "Temporal", "text": [ "prior" ], "offsets": [ [ 886, 891 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T55", "type": "Observation", "text": [ "adequate support" ], "offsets": [ [ 926, 942 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T56", "type": "Procedure", "text": [ "fixation to the devices" ], "offsets": [ [ 950, 973 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T57", "type": "Measurement", "text": [ "cannot" ], "offsets": [ [ 911, 917 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T58", "type": "Scope", "text": [ "adequate support and/or fixation to the devices" ], "offsets": [ [ 926, 973 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T59", "type": "Scope", "text": [ "disease, infection or prior implantation which cannot provide adequate support and/or fixation to the devices" ], "offsets": [ [ 864, 973 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T60", "type": "Condition", "text": [ "bone abnormalities" ], "offsets": [ [ 987, 1005 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T61", "type": "Procedure", "text": [ "screw fixation" ], "offsets": [ [ 1022, 1036 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T62", "type": "Negation", "text": [ "preventing" ], "offsets": [ [ 1006, 1016 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T63", "type": "Qualifier", "text": [ "safe" ], "offsets": [ [ 1017, 1021 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T64", "type": "Scope", "text": [ "preventing safe screw fixation" ], "offsets": [ [ 1006, 1036 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T65", "type": "Condition", "text": [ "rapid joint disease" ], "offsets": [ [ 1079, 1098 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T66", "type": "Condition", "text": [ "bone absorption" ], "offsets": [ [ 1100, 1115 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T67", "type": "Condition", "text": [ "osteopenia" ], "offsets": [ [ 1117, 1127 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T68", "type": "Condition", "text": [ "osteomalacia" ], "offsets": [ [ 1129, 1141 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T69", "type": "Condition", "text": [ "osteoporosis" ], "offsets": [ [ 1150, 1162 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T70", "type": "Condition", "text": [ "Osteoporosis" ], "offsets": [ [ 1164, 1176 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T71", "type": "Condition", "text": [ "osteopenia" ], "offsets": [ [ 1180, 1190 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T72", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 1204, 1221 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T73", "type": "Qualifier", "text": [ "relative" ], "offsets": [ [ 1195, 1203 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T74", "type": "Condition", "text": [ "sensitivity" ], "offsets": [ [ 1376, 1387 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T75", "type": "Device", "text": [ "metal" ], "offsets": [ [ 1370, 1375 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T76", "type": "Mood", "text": [ "documented" ], "offsets": [ [ 1346, 1356 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T77", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 1360, 1369 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T78", "type": "Scope", "text": [ "documented or suspected" ], "offsets": [ [ 1346, 1369 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T79", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 1400, 1408 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T80", "type": "Observation", "text": [ "anatomical structures" ], "offsets": [ [ 1422, 1443 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T81", "type": "Observation", "text": [ "physiological performance" ], "offsets": [ [ 1447, 1472 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T82", "type": "Observation", "text": [ " utilization", "as inadequa" ], "offsets": [ [ 1506, 1518 ], [ 1529, 1540 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T83", "type": "Device", "text": [ "implant" ], "offsets": [ [ 1499, 1506 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T84", "type": "Scope", "text": [ "anatomical structures or physiological performance" ], "offsets": [ [ 1422, 1472 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T85", "type": "Condition", "text": [ "inadequate tissue coverage" ], "offsets": [ [ 1532, 1558 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T86", "type": "Qualifier", "text": [ "operative site" ], "offsets": [ [ 1568, 1582 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T87", "type": "Condition", "text": [ "surgical conditions" ], "offsets": [ [ 1613, 1632 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T88", "type": "Condition", "text": [ "itions", "reclude th" ], "offsets": [ [ 1626, 1632 ], [ 1646, 1656 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T89", "type": "Negation", "text": [ "preclude" ], "offsets": [ [ 1645, 1653 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T90", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 1679, 1686 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T91", "type": "Condition", "text": [ "congenital abnormalities" ], "offsets": [ [ 1696, 1720 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T92", "type": "Condition", "text": [ "immunosuppressive disease" ], "offsets": [ [ 1722, 1747 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T93", "type": "Value", "text": [ "elevation" ], "offsets": [ [ 1749, 1758 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T94", "type": "Measurement", "text": [ "sedimentation rate" ], "offsets": [ [ 1762, 1780 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T95", "type": "Qualifier", "text": [ "unexplained by other diseases" ], "offsets": [ [ 1781, 1810 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T96", "type": "Value", "text": [ "elevation" ], "offsets": [ [ 1812, 1821 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T97", "type": "Measurement", "text": [ "white blood count (WBC)" ], "offsets": [ [ 1825, 1848 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T98", "type": "Value", "text": [ "left shift" ], "offsets": [ [ 1860, 1870 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T99", "type": "Measurement", "text": [ "WBC differential count" ], "offsets": [ [ 1878, 1900 ] ], "normalized": [] }, { "id": "NCT03077204_inc_T101", "type": "Condition", "text": [ "open wounds" ], "offsets": [ [ 1054, 1065 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03077204_inc_R1", "type": "Has_scope", "arg1_id": "NCT03077204_inc_T5", "arg2_id": "NCT03077204_inc_T6", "normalized": [] }, { "id": "NCT03077204_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03077204_inc_T9", "arg2_id": "NCT03077204_inc_T10", "normalized": [] }, { "id": "NCT03077204_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03077204_inc_T11", "arg2_id": "NCT03077204_inc_T12", "normalized": [] }, { "id": "NCT03077204_inc_R4", "type": "AND", "arg1_id": "NCT03077204_inc_T11", "arg2_id": "NCT03077204_inc_T13", "normalized": [] }, { "id": "NCT03077204_inc_R5", "type": "AND", "arg1_id": "NCT03077204_inc_T9", "arg2_id": "NCT03077204_inc_T11", "normalized": [] }, { "id": "NCT03077204_inc_R6", "type": "Subsumes", "arg1_id": "NCT03077204_inc_T14", "arg2_id": "NCT03077204_inc_T15", "normalized": [] }, { "id": "NCT03077204_inc_R7", "type": "Subsumes", "arg1_id": "NCT03077204_inc_T23", "arg2_id": "NCT03077204_inc_T22", "normalized": [] }, { "id": "NCT03077204_inc_R8", "type": "Has_temporal", "arg1_id": "NCT03077204_inc_T25", "arg2_id": "NCT03077204_inc_T27", "normalized": [] }, { "id": "NCT03077204_inc_R9", "type": "Has_qualifier", "arg1_id": "NCT03077204_inc_T25", "arg2_id": "NCT03077204_inc_T26", "normalized": [] }, { "id": "NCT03077204_inc_R10", "type": "AND", "arg1_id": "NCT03077204_inc_T31", "arg2_id": "NCT03077204_inc_T28", "normalized": [] }, { "id": "NCT03077204_inc_R11", "type": "Has_qualifier", "arg1_id": "NCT03077204_inc_T40", "arg2_id": "NCT03077204_inc_T41", "normalized": [] }, { "id": "NCT03077204_inc_R12", "type": "Has_mood", "arg1_id": "NCT03077204_inc_T48", "arg2_id": "NCT03077204_inc_T47", "normalized": [] }, { "id": "NCT03077204_inc_R13", "type": "Has_qualifier", "arg1_id": "NCT03077204_inc_T48", "arg2_id": "NCT03077204_inc_T45", "normalized": [] }, { "id": "NCT03077204_inc_R14", "type": "Has_scope", "arg1_id": "NCT03077204_inc_T49", "arg2_id": "NCT03077204_inc_T48", "normalized": [] }, { "id": "NCT03077204_inc_R15", "type": "AND", "arg1_id": "NCT03077204_inc_T58", "arg2_id": "NCT03077204_inc_T57", "normalized": [] }, { "id": "NCT03077204_inc_R16", "type": "Has_temporal", "arg1_id": "NCT03077204_inc_T53", "arg2_id": "NCT03077204_inc_T54", "normalized": [] }, { "id": "NCT03077204_inc_R17", "type": "Has_scope", "arg1_id": "NCT03077204_inc_T53", "arg2_id": "NCT03077204_inc_T58", "normalized": [] }, { "id": "NCT03077204_inc_R18", "type": "Has_scope", "arg1_id": "NCT03077204_inc_T50", "arg2_id": "NCT03077204_inc_T59", "normalized": [] }, { "id": "NCT03077204_inc_R19", "type": "Has_qualifier", "arg1_id": "NCT03077204_inc_T61", "arg2_id": "NCT03077204_inc_T63", "normalized": [] }, { "id": "NCT03077204_inc_R20", "type": "Has_negation", "arg1_id": "NCT03077204_inc_T61", "arg2_id": "NCT03077204_inc_T62", "normalized": [] }, { "id": "NCT03077204_inc_R21", "type": "Has_scope", "arg1_id": "NCT03077204_inc_T60", "arg2_id": "NCT03077204_inc_T64", "normalized": [] }, { "id": "NCT03077204_inc_R22", "type": "Has_qualifier", "arg1_id": "NCT03077204_inc_T72", "arg2_id": "NCT03077204_inc_T73", "normalized": [] }, { "id": "NCT03077204_inc_R23", "type": "Subsumes", "arg1_id": "NCT03077204_inc_T67", "arg2_id": "NCT03077204_inc_T71", "normalized": [] }, { "id": "NCT03077204_inc_R24", "type": "Subsumes", "arg1_id": "NCT03077204_inc_T69", "arg2_id": "NCT03077204_inc_T70", "normalized": [] }, { "id": "NCT03077204_inc_R25", "type": "AND", "arg1_id": "NCT03077204_inc_T71", "arg2_id": "NCT03077204_inc_T72", "normalized": [] }, { "id": "NCT03077204_inc_R26", "type": "AND", "arg1_id": "NCT03077204_inc_T70", "arg2_id": "NCT03077204_inc_T72", "normalized": [] }, { "id": "NCT03077204_inc_R27", "type": "AND", "arg1_id": "NCT03077204_inc_T74", "arg2_id": "NCT03077204_inc_T75", "normalized": [] }, { "id": "NCT03077204_inc_R28", "type": "Has_scope", "arg1_id": "NCT03077204_inc_T74", "arg2_id": "NCT03077204_inc_T78", "normalized": [] }, { "id": "NCT03077204_inc_R29", "type": "AND", "arg1_id": "NCT03077204_inc_T82", "arg2_id": "NCT03077204_inc_T83", "normalized": [] }, { "id": "NCT03077204_inc_R31", "type": "Has_qualifier", "arg1_id": "NCT03077204_inc_T85", "arg2_id": "NCT03077204_inc_T86", "normalized": [] }, { "id": "NCT03077204_inc_R32", "type": "Has_value", "arg1_id": "NCT03077204_inc_T94", "arg2_id": "NCT03077204_inc_T93", "normalized": [] }, { "id": "NCT03077204_inc_R33", "type": "Has_value", "arg1_id": "NCT03077204_inc_T97", "arg2_id": "NCT03077204_inc_T96", "normalized": [] }, { "id": "NCT03077204_inc_R34", "type": "Has_value", "arg1_id": "NCT03077204_inc_T99", "arg2_id": "NCT03077204_inc_T98", "normalized": [] }, { "id": "NCT03077204_inc_R35", "type": "Has_qualifier", "arg1_id": "NCT03077204_inc_T94", "arg2_id": "NCT03077204_inc_T95", "normalized": [] } ]

[ { "id": "NCT03079141_exc_text", "type": "exclusion", "text": [ "Any previous treatments for active CSC;\nPrevious prescription of mineralocorticoid receptor antagonists, for cCSC or for other diseases;\nCurrent treatment with corticosteroids (topical or systemic), corticosteroid use within 3 months before possible start of trial treatment, or anticipated start of corticosteroid treatment within the first 2 years from the start of the trial period;\nEvidence of another diagnosis that can explain serous SRF or visual loss;\nBest-corrected visual acuity < 20/200 (Snellen equivalent);\nProfound chorioretinal atrophy in central macular area on ophthalmoscopy and OCT;\nMyopia > 6D;\nVisual loss and/or serous detachment on OCT < 6 weeks;\nContinuous and/or progressive visual loss > 18 months or serous detachment on OCT > 18 months;\nNo hyperfluorescence on ICGA;\nIntraretinal edema on OCT;\n(relative) Contraindications for FA or ICGA;\n(relative) Contraindications for photodynamic treatment (pregnancy, porphyria, severely disturbed liver function). Pregnancy will not be routinely tested in female patients, but the possibility of pregnancy will be discussed during screening\n(relative) Known contraindications for initiation of eplerenone treatment (hyperkalemia, abnormal renal clearance, severe hepatic insufficiency (Child-Pugh C), type 2 diabetes mellitus with microalbuminuria, concomitant use of potassium supplements, potassium-sparing diuretics, strong CYP3A4 inhibitors, or the combination of an ACE-inhibitor and an angiotensin receptor blocking agent). Pregnancy will not be routinely tested in female patients, but the possibility of pregnancy will be discussed during screening;\nSoft drusen in treated eye or fellow eye, signs of choroidal neovascularization on ophthalmoscopy and/or FA/ICGA of the study eye.\n" ], "offsets": [ [ 0, 1757 ] ] } ]

[ { "id": "NCT03079141_exc_T1", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 28, 34 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T2", "type": "Condition", "text": [ "CSC" ], "offsets": [ [ 35, 38 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T3", "type": "Procedure", "text": [ "treatments" ], "offsets": [ [ 13, 23 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T4", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 4, 12 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T5", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 40, 48 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T6", "type": "Drug", "text": [ "mineralocorticoid receptor antagonists" ], "offsets": [ [ 65, 103 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T7", "type": "Condition", "text": [ "cCSC" ], "offsets": [ [ 109, 113 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T8", "type": "Condition", "text": [ "other diseases" ], "offsets": [ [ 121, 135 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T9", "type": "Scope", "text": [ "cCSC or for other diseases" ], "offsets": [ [ 109, 135 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T10", "type": "Drug", "text": [ "corticosteroids" ], "offsets": [ [ 160, 175 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T11", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 137, 144 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T12", "type": "Qualifier", "text": [ "topical" ], "offsets": [ [ 177, 184 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T13", "type": "Qualifier", "text": [ "systemic" ], "offsets": [ [ 188, 196 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T14", "type": "Scope", "text": [ "topical or systemic" ], "offsets": [ [ 177, 196 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T15", "type": "Procedure", "text": [ "corticosteroid use" ], "offsets": [ [ 199, 217 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T16", "type": "Temporal", "text": [ "within 3 months before possible start of trial treatment" ], "offsets": [ [ 218, 274 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T17", "type": "Reference_point", "text": [ "possible start of trial treatment" ], "offsets": [ [ 241, 274 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T18", "type": "Procedure", "text": [ "corticosteroid treatment" ], "offsets": [ [ 300, 324 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T19", "type": "Temporal", "text": [ "within the first 2 years from the start of the trial period" ], "offsets": [ [ 325, 384 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T20", "type": "Reference_point", "text": [ "the first 2 years from the start of the trial period" ], "offsets": [ [ 332, 384 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T21", "type": "Mood", "text": [ "anticipated" ], "offsets": [ [ 279, 290 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T23", "type": "Measurement", "text": [ "Best-corrected visual acuity" ], "offsets": [ [ 460, 488 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T24", "type": "Value", "text": [ "< 20/200" ], "offsets": [ [ 489, 497 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T25", "type": "Qualifier", "text": [ "Profound" ], "offsets": [ [ 520, 528 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T26", "type": "Condition", "text": [ "chorioretinal atrophy" ], "offsets": [ [ 529, 550 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T27", "type": "Qualifier", "text": [ "central macular area" ], "offsets": [ [ 554, 574 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T28", "type": "Procedure", "text": [ "ophthalmoscopy" ], "offsets": [ [ 578, 592 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T29", "type": "Procedure", "text": [ "OCT" ], "offsets": [ [ 597, 600 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T30", "type": "Scope", "text": [ "ophthalmoscopy and OCT" ], "offsets": [ [ 578, 600 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T31", "type": "Measurement", "text": [ "Myopia" ], "offsets": [ [ 602, 608 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T32", "type": "Value", "text": [ "> 6D" ], "offsets": [ [ 609, 613 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T33", "type": "Condition", "text": [ "Visual loss" ], "offsets": [ [ 615, 626 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T34", "type": "Condition", "text": [ "serous detachment" ], "offsets": [ [ 634, 651 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T35", "type": "Procedure", "text": [ "OCT" ], "offsets": [ [ 655, 658 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T36", "type": "Temporal", "text": [ "< 6 weeks" ], "offsets": [ [ 659, 668 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T37", "type": "Scope", "text": [ "Visual loss and/or serous detachment" ], "offsets": [ [ 615, 651 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T38", "type": "Qualifier", "text": [ "Continuous" ], "offsets": [ [ 670, 680 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T39", "type": "Qualifier", "text": [ "progressive" ], "offsets": [ [ 688, 699 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T40", "type": "Condition", "text": [ "visual loss" ], "offsets": [ [ 700, 711 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T41", "type": "Scope", "text": [ "Continuous and/or progressive" ], "offsets": [ [ 670, 699 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T42", "type": "Temporal", "text": [ "> 18 months" ], "offsets": [ [ 712, 723 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T43", "type": "Condition", "text": [ "serous detachment" ], "offsets": [ [ 727, 744 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T44", "type": "Procedure", "text": [ "OCT" ], "offsets": [ [ 748, 751 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T45", "type": "Temporal", "text": [ "> 18 months" ], "offsets": [ [ 752, 763 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T46", "type": "Measurement", "text": [ "ICGA" ], "offsets": [ [ 789, 793 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T47", "type": "Value", "text": [ "hyperfluorescence" ], "offsets": [ [ 768, 785 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T48", "type": "Negation", "text": [ "No" ], "offsets": [ [ 765, 767 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T49", "type": "Condition", "text": [ "Intraretinal edema" ], "offsets": [ [ 795, 813 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T50", "type": "Procedure", "text": [ "OCT" ], "offsets": [ [ 817, 820 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T51", "type": "Condition", "text": [ "Contraindications" ], "offsets": [ [ 833, 850 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T52", "type": "Procedure", "text": [ "FA" ], "offsets": [ [ 855, 857 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T53", "type": "Procedure", "text": [ "ICGA" ], "offsets": [ [ 861, 865 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T54", "type": "Scope", "text": [ "FA or ICGA" ], "offsets": [ [ 855, 865 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T55", "type": "Condition", "text": [ "Contraindications" ], "offsets": [ [ 878, 895 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T56", "type": "Procedure", "text": [ "photodynamic treatment" ], "offsets": [ [ 900, 922 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T57", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 924, 933 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T58", "type": "Condition", "text": [ "porphyria" ], "offsets": [ [ 935, 944 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T59", "type": "Qualifier", "text": [ "severely" ], "offsets": [ [ 946, 954 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T60", "type": "Condition", "text": [ "disturbed liver function" ], "offsets": [ [ 955, 979 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T61", "type": "Scope", "text": [ "pregnancy, porphyria, severely disturbed liver function" ], "offsets": [ [ 924, 979 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T62", "type": "Scope", "text": [ "Contraindications for photodynamic treatment" ], "offsets": [ [ 878, 922 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T64", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 1126, 1143 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T65", "type": "Drug", "text": [ "eplerenone" ], "offsets": [ [ 1162, 1172 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T66", "type": "Condition", "text": [ "hyperkalemia" ], "offsets": [ [ 1184, 1196 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T67", "type": "Condition", "text": [ "abnormal renal clearance" ], "offsets": [ [ 1198, 1222 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T68", "type": "Measurement", "text": [ "renal clearance" ], "offsets": [ [ 1207, 1222 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T69", "type": "Value", "text": [ "abnormal" ], "offsets": [ [ 1198, 1206 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T70", "type": "Condition", "text": [ "severe hepatic insufficiency" ], "offsets": [ [ 1224, 1252 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T71", "type": "Measurement", "text": [ "Child-Pugh" ], "offsets": [ [ 1254, 1264 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T72", "type": "Value", "text": [ "C" ], "offsets": [ [ 1265, 1266 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T73", "type": "Condition", "text": [ "type 2 diabetes mellitus" ], "offsets": [ [ 1269, 1293 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T74", "type": "Condition", "text": [ "microalbuminuria" ], "offsets": [ [ 1299, 1315 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T75", "type": "Scope", "text": [ "type 2 diabetes mellitus with microalbuminuria" ], "offsets": [ [ 1269, 1315 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T76", "type": "Temporal", "text": [ "concomitant" ], "offsets": [ [ 1317, 1328 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T77", "type": "Drug", "text": [ "potassium supplements" ], "offsets": [ [ 1336, 1357 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T78", "type": "Drug", "text": [ "potassium-sparing diuretics" ], "offsets": [ [ 1359, 1386 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T79", "type": "Drug", "text": [ "strong CYP3A4 inhibitors" ], "offsets": [ [ 1388, 1412 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T80", "type": "Drug", "text": [ "ACE-inhibitor" ], "offsets": [ [ 1439, 1452 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T81", "type": "Drug", "text": [ "angiotensin receptor blocking agent" ], "offsets": [ [ 1460, 1495 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T82", "type": "Scope", "text": [ "ACE-inhibitor and an angiotensin receptor blocking agent" ], "offsets": [ [ 1439, 1495 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T83", "type": "Scope", "text": [ "potassium supplements, potassium-sparing diuretics, strong CYP3A4 inhibitors, or the combination of an ACE-inhibitor and an angiotensin receptor blocking agent" ], "offsets": [ [ 1336, 1495 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T85", "type": "Condition", "text": [ "Soft drusen" ], "offsets": [ [ 1626, 1637 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T86", "type": "Qualifier", "text": [ "treated eye" ], "offsets": [ [ 1641, 1652 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T87", "type": "Qualifier", "text": [ "fellow eye" ], "offsets": [ [ 1656, 1666 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T88", "type": "Scope", "text": [ "treated eye or fellow eye" ], "offsets": [ [ 1641, 1666 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T89", "type": "Condition", "text": [ "choroidal neovascularization" ], "offsets": [ [ 1677, 1705 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T90", "type": "Procedure", "text": [ "ophthalmoscopy" ], "offsets": [ [ 1709, 1723 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T91", "type": "Procedure", "text": [ "FA" ], "offsets": [ [ 1731, 1733 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T92", "type": "Procedure", "text": [ "ICGA" ], "offsets": [ [ 1734, 1738 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T93", "type": "Qualifier", "text": [ "study eye" ], "offsets": [ [ 1746, 1755 ] ], "normalized": [] }, { "id": "NCT03079141_exc_T94", "type": "Scope", "text": [ "ophthalmoscopy and/or FA/ICGA" ], "offsets": [ [ 1709, 1738 ] ], "normalized": [] } ]

[]

[]

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"NCT03079141_exc_R8", "type": "Has_index", "arg1_id": "NCT03079141_exc_T16", "arg2_id": "NCT03079141_exc_T17", "normalized": [] }, { "id": "NCT03079141_exc_R9", "type": "Has_index", "arg1_id": "NCT03079141_exc_T19", "arg2_id": "NCT03079141_exc_T20", "normalized": [] }, { "id": "NCT03079141_exc_R10", "type": "Has_mood", "arg1_id": "NCT03079141_exc_T18", "arg2_id": "NCT03079141_exc_T21", "normalized": [] }, { "id": "NCT03079141_exc_R11", "type": "Has_temporal", "arg1_id": "NCT03079141_exc_T18", "arg2_id": "NCT03079141_exc_T19", "normalized": [] }, { "id": "NCT03079141_exc_R12", "type": "Has_temporal", "arg1_id": "NCT03079141_exc_T15", "arg2_id": "NCT03079141_exc_T16", "normalized": [] }, { "id": "NCT03079141_exc_R13", "type": "Has_value", "arg1_id": "NCT03079141_exc_T23", "arg2_id": "NCT03079141_exc_T24", "normalized": [] }, { "id": "NCT03079141_exc_R14", "type": "Has_qualifier", "arg1_id": "NCT03079141_exc_T26", "arg2_id": "NCT03079141_exc_T25", "normalized": [] }, { "id": "NCT03079141_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT03079141_exc_T26", "arg2_id": "NCT03079141_exc_T27", "normalized": [] }, { "id": "NCT03079141_exc_R16", "type": "AND", "arg1_id": "NCT03079141_exc_T30", "arg2_id": "NCT03079141_exc_T26", "normalized": [] }, { "id": "NCT03079141_exc_R17", "type": "Has_value", "arg1_id": "NCT03079141_exc_T31", "arg2_id": "NCT03079141_exc_T32", "normalized": [] }, { "id": "NCT03079141_exc_R18", "type": "Has_scope", "arg1_id": "NCT03079141_exc_T35", "arg2_id": "NCT03079141_exc_T37", "normalized": [] }, { "id": "NCT03079141_exc_R19", "type": "Has_temporal", "arg1_id": "NCT03079141_exc_T35", "arg2_id": "NCT03079141_exc_T36", "normalized": [] }, { "id": "NCT03079141_exc_R20", "type": "Has_scope", "arg1_id": "NCT03079141_exc_T40", "arg2_id": "NCT03079141_exc_T41", "normalized": [] }, { "id": "NCT03079141_exc_R21", "type": "Has_temporal", "arg1_id": "NCT03079141_exc_T44", "arg2_id": "NCT03079141_exc_T45", "normalized": [] }, { "id": "NCT03079141_exc_R22", "type": "Has_temporal", "arg1_id": "NCT03079141_exc_T40", "arg2_id": "NCT03079141_exc_T42", "normalized": [] }, { "id": "NCT03079141_exc_R23", "type": "AND", "arg1_id": "NCT03079141_exc_T44", "arg2_id": "NCT03079141_exc_T43", "normalized": [] }, { "id": "NCT03079141_exc_R24", "type": "Has_negation", "arg1_id": "NCT03079141_exc_T47", "arg2_id": "NCT03079141_exc_T48", "normalized": [] }, { "id": "NCT03079141_exc_R25", "type": "Has_value", "arg1_id": "NCT03079141_exc_T46", "arg2_id": "NCT03079141_exc_T47", "normalized": [] }, { "id": "NCT03079141_exc_R26", "type": "AND", "arg1_id": "NCT03079141_exc_T50", "arg2_id": "NCT03079141_exc_T49", "normalized": [] }, { "id": "NCT03079141_exc_R27", "type": "Has_scope", "arg1_id": "NCT03079141_exc_T51", "arg2_id": "NCT03079141_exc_T54", "normalized": [] }, { "id": "NCT03079141_exc_R28", "type": "Has_qualifier", "arg1_id": "NCT03079141_exc_T60", "arg2_id": "NCT03079141_exc_T59", "normalized": [] }, { "id": "NCT03079141_exc_R29", "type": "AND", "arg1_id": "NCT03079141_exc_T55", "arg2_id": "NCT03079141_exc_T56", "normalized": [] }, { "id": "NCT03079141_exc_R30", "type": "Subsumes", "arg1_id": "NCT03079141_exc_T62", "arg2_id": "NCT03079141_exc_T61", "normalized": [] }, { "id": "NCT03079141_exc_R31", "type": "Has_value", "arg1_id": "NCT03079141_exc_T68", "arg2_id": "NCT03079141_exc_T69", "normalized": [] }, { "id": "NCT03079141_exc_R32", "type": "Has_value", "arg1_id": "NCT03079141_exc_T71", "arg2_id": "NCT03079141_exc_T72", "normalized": [] }, { "id": "NCT03079141_exc_R33", "type": "AND", "arg1_id": "NCT03079141_exc_T64", "arg2_id": "NCT03079141_exc_T65", "normalized": [] }, { "id": "NCT03079141_exc_R35", "type": "Subsumes", "arg1_id": "NCT03079141_exc_T70", "arg2_id": "NCT03079141_exc_T71", "normalized": [] }, { "id": "NCT03079141_exc_R36", "type": "Has_temporal", "arg1_id": "NCT03079141_exc_T83", "arg2_id": "NCT03079141_exc_T76", "normalized": [] }, { "id": "NCT03079141_exc_R38", "type": "Has_scope", "arg1_id": "NCT03079141_exc_T85", "arg2_id": "NCT03079141_exc_T88", "normalized": [] }, { "id": "NCT03079141_exc_R37", "type": "AND", "arg1_id": "NCT03079141_exc_T94", "arg2_id": "NCT03079141_exc_T89", "normalized": [] }, { "id": "NCT03079141_exc_R39", "type": "Has_qualifier", "arg1_id": "NCT03079141_exc_T94", "arg2_id": "NCT03079141_exc_T93", "normalized": [] } ]

[ { "id": "NCT03079141_inc_text", "type": "inclusion", "text": [ "Age of = 18 years of age and able to give written informed consent;\nActive chronic central serous chorioretinopathy (cCSC);\nSubjective visual loss > 6 weeks, interpreted as onset of active disease;\nFoveal subretinal fluid (SRF), on optical coherence tomography (OCT), at Baseline Examination;\n=1 ill-defined hyperfluorescent leakage areas on fluorescein angiography (FA) with retinal pigment epithelial window defect(s) that are compatible with cCSC;\nHyperfluorescent areas on indocyanine green angiography (ICGA).\n" ], "offsets": [ [ 0, 515 ] ] } ]

[ { "id": "NCT03079141_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T2", "type": "Value", "text": [ "= 18 years" ], "offsets": [ [ 7, 17 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T3", "type": "Observation", "text": [ "able to give written informed consent" ], "offsets": [ [ 29, 66 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T4", "type": "Qualifier", "text": [ "Active" ], "offsets": [ [ 68, 74 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T5", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 75, 82 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T6", "type": "Condition", "text": [ "central serous chorioretinopathy (cCSC)" ], "offsets": [ [ 83, 122 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T7", "type": "Condition", "text": [ "Subjective visual loss" ], "offsets": [ [ 124, 146 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T8", "type": "Temporal", "text": [ "> 6 weeks" ], "offsets": [ [ 147, 156 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T10", "type": "Condition", "text": [ "Foveal subretinal fluid (SRF)" ], "offsets": [ [ 198, 227 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T11", "type": "Procedure", "text": [ "optical coherence tomography (OCT)" ], "offsets": [ [ 232, 266 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T12", "type": "Temporal", "text": [ "at Baseline Examination" ], "offsets": [ [ 268, 291 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T13", "type": "Reference_point", "text": [ "Baseline Examination" ], "offsets": [ [ 271, 291 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T14", "type": "Multiplier", "text": [ "=1" ], "offsets": [ [ 293, 295 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T15", "type": "Qualifier", "text": [ "ill-defined" ], "offsets": [ [ 296, 307 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T16", "type": "Condition", "text": [ "hyperfluorescent leakage areas" ], "offsets": [ [ 308, 338 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T17", "type": "Procedure", "text": [ "fluorescein angiography (FA)" ], "offsets": [ [ 342, 370 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T18", "type": "Condition", "text": [ "retinal pigment epithelial window defect(s)" ], "offsets": [ [ 376, 419 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T20", "type": "Condition", "text": [ "Hyperfluorescent areas" ], "offsets": [ [ 451, 473 ] ], "normalized": [] }, { "id": "NCT03079141_inc_T21", "type": "Procedure", "text": [ "indocyanine green angiography (ICGA)" ], "offsets": [ [ 477, 513 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03079141_inc_R1", "type": "Has_value", "arg1_id": "NCT03079141_inc_T1", "arg2_id": "NCT03079141_inc_T2", "normalized": [] }, { "id": "NCT03079141_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03079141_inc_T6", "arg2_id": "NCT03079141_inc_T5", "normalized": [] }, { "id": "NCT03079141_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03079141_inc_T6", "arg2_id": "NCT03079141_inc_T4", "normalized": [] }, { "id": "NCT03079141_inc_R4", "type": "Has_temporal", "arg1_id": "NCT03079141_inc_T7", "arg2_id": "NCT03079141_inc_T8", "normalized": [] }, { "id": "NCT03079141_inc_R5", "type": "AND", "arg1_id": "NCT03079141_inc_T11", "arg2_id": "NCT03079141_inc_T10", "normalized": [] }, { "id": "NCT03079141_inc_R6", "type": "Has_temporal", "arg1_id": "NCT03079141_inc_T11", "arg2_id": "NCT03079141_inc_T12", "normalized": [] }, { "id": "NCT03079141_inc_R7", "type": "Has_index", "arg1_id": "NCT03079141_inc_T12", "arg2_id": "NCT03079141_inc_T13", "normalized": [] }, { "id": "NCT03079141_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT03079141_inc_T16", "arg2_id": "NCT03079141_inc_T15", "normalized": [] }, { "id": "NCT03079141_inc_R9", "type": "Has_multiplier", "arg1_id": "NCT03079141_inc_T16", "arg2_id": "NCT03079141_inc_T14", "normalized": [] }, { "id": "NCT03079141_inc_R10", "type": "AND", "arg1_id": "NCT03079141_inc_T17", "arg2_id": "NCT03079141_inc_T16", "normalized": [] }, { "id": "NCT03079141_inc_R11", "type": "AND", "arg1_id": "NCT03079141_inc_T17", "arg2_id": "NCT03079141_inc_T18", "normalized": [] }, { "id": "NCT03079141_inc_R12", "type": "AND", "arg1_id": "NCT03079141_inc_T21", "arg2_id": "NCT03079141_inc_T20", "normalized": [] } ]

[ { "id": "NCT03080493_exc_text", "type": "exclusion", "text": [ "Current use of gabapentin or pregabalin\nAllergy to gabapentin, acetaminophen, codeine, or ibuprofen\nSelf reported renal disease (severe impaired renal function)\nSelf reported current or chronic narcotic use (typical daily use)\nWomen with any issue that, in the opinion of the investigator, would interfere with study participation or generating accurate study data\n" ], "offsets": [ [ 0, 365 ] ] } ]

[ { "id": "NCT03080493_exc_T1", "type": "Drug", "text": [ "gabapentin" ], "offsets": [ [ 15, 25 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T2", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T3", "type": "Drug", "text": [ "pregabalin" ], "offsets": [ [ 29, 39 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T4", "type": "Scope", "text": [ "gabapentin or pregabalin" ], "offsets": [ [ 15, 39 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T5", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 40, 47 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T6", "type": "Drug", "text": [ "gabapentin" ], "offsets": [ [ 51, 61 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T7", "type": "Drug", "text": [ "acetaminophen" ], "offsets": [ [ 63, 76 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T8", "type": "Drug", "text": [ "codeine" ], "offsets": [ [ 78, 85 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T9", "type": "Drug", "text": [ "ibuprofen" ], "offsets": [ [ 90, 99 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T10", "type": "Scope", "text": [ "gabapentin, acetaminophen, codeine, or ibuprofen" ], "offsets": [ [ 51, 99 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T11", "type": "Qualifier", "text": [ "Self reported" ], "offsets": [ [ 100, 113 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T12", "type": "Condition", "text": [ "renal disease" ], "offsets": [ [ 114, 127 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T13", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 129, 135 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T14", "type": "Condition", "text": [ "impaired renal function" ], "offsets": [ [ 136, 159 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T15", "type": "Scope", "text": [ "Self reported renal disease" ], "offsets": [ [ 100, 127 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T16", "type": "Scope", "text": [ "severe impaired renal function" ], "offsets": [ [ 129, 159 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T17", "type": "Qualifier", "text": [ "Self reported" ], "offsets": [ [ 161, 174 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T18", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 175, 182 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T19", "type": "Qualifier", "text": [ "chronic" ], "offsets": [ [ 186, 193 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T20", "type": "Condition", "text": [ "narcotic use" ], "offsets": [ [ 194, 206 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T21", "type": "Scope", "text": [ "current or chronic" ], "offsets": [ [ 175, 193 ] ], "normalized": [] }, { "id": "NCT03080493_exc_T22", "type": "Multiplier", "text": [ "daily use" ], "offsets": [ [ 216, 225 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03080493_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03080493_exc_T4", "arg2_id": "NCT03080493_exc_T2", "normalized": [] }, { "id": "NCT03080493_exc_R2", "type": "Has_scope", "arg1_id": "NCT03080493_exc_T5", "arg2_id": "NCT03080493_exc_T10", "normalized": [] }, { "id": "NCT03080493_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03080493_exc_T12", "arg2_id": "NCT03080493_exc_T11", "normalized": [] }, { "id": "NCT03080493_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03080493_exc_T14", "arg2_id": "NCT03080493_exc_T13", "normalized": [] }, { "id": "NCT03080493_exc_R5", "type": "Subsumes", "arg1_id": "NCT03080493_exc_T15", "arg2_id": "NCT03080493_exc_T16", "normalized": [] }, { "id": "NCT03080493_exc_R6", "type": "Has_scope", "arg1_id": "NCT03080493_exc_T20", "arg2_id": "NCT03080493_exc_T21", "normalized": [] }, { "id": "NCT03080493_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03080493_exc_T20", "arg2_id": "NCT03080493_exc_T17", "normalized": [] }, { "id": "NCT03080493_exc_R8", "type": "Has_multiplier", "arg1_id": "NCT03080493_exc_T20", "arg2_id": "NCT03080493_exc_T22", "normalized": [] } ]

[ { "id": "NCT03080493_inc_text", "type": "inclusion", "text": [ "15 weeks 0 days gestational age - 23 weeks 5 days gestational age at time of dilator insertion\nAble to read and write in English\nActive cell phone with text messaging capability\nRide home from dilator insertion clinic appointment\n" ], "offsets": [ [ 0, 230 ] ] } ]

[ { "id": "NCT03080493_inc_T1", "type": "Value", "text": [ "15 weeks 0 days", "- 23 weeks 5 days" ], "offsets": [ [ 0, 15 ], [ 32, 49 ] ], "normalized": [] }, { "id": "NCT03080493_inc_T2", "type": "Measurement", "text": [ "gestational age" ], "offsets": [ [ 16, 31 ] ], "normalized": [] }, { "id": "NCT03080493_inc_T3", "type": "Temporal", "text": [ "at time of dilator insertion" ], "offsets": [ [ 66, 94 ] ], "normalized": [] }, { "id": "NCT03080493_inc_T4", "type": "Reference_point", "text": [ "dilator insertion" ], "offsets": [ [ 77, 94 ] ], "normalized": [] }, { "id": "NCT03080493_inc_T5", "type": "Observation", "text": [ "Able to read and write in English" ], "offsets": [ [ 95, 128 ] ], "normalized": [] }, { "id": "NCT03080493_inc_T6", "type": "Observation", "text": [ "Active cell phone with text messaging capability" ], "offsets": [ [ 129, 177 ] ], "normalized": [] }, { "id": "NCT03080493_inc_T7", "type": "Observation", "text": [ "Ride home" ], "offsets": [ [ 178, 187 ] ], "normalized": [] }, { "id": "NCT03080493_inc_T8", "type": "Procedure", "text": [ "dilator insertion" ], "offsets": [ [ 193, 210 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03080493_inc_R1", "type": "Has_value", "arg1_id": "NCT03080493_inc_T2", "arg2_id": "NCT03080493_inc_T1", "normalized": [] }, { "id": "NCT03080493_inc_R2", "type": "Has_index", "arg1_id": "NCT03080493_inc_T3", "arg2_id": "NCT03080493_inc_T4", "normalized": [] }, { "id": "NCT03080493_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03080493_inc_T2", "arg2_id": "NCT03080493_inc_T3", "normalized": [] }, { "id": "NCT03080493_inc_R4", "type": "AND", "arg1_id": "NCT03080493_inc_T7", "arg2_id": "NCT03080493_inc_T8", "normalized": [] } ]

[ { "id": "NCT03082573_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT03082573_inc_text", "type": "inclusion", "text": [ "Fluent in reading and writing in English language.\n= 21 years of age at the time of participation.\n" ], "offsets": [ [ 0, 99 ] ] } ]

[ { "id": "NCT03082573_inc_T2", "type": "Person", "text": [ "age" ], "offsets": [ [ 65, 68 ] ], "normalized": [] }, { "id": "NCT03082573_inc_T3", "type": "Value", "text": [ "= 21 years" ], "offsets": [ [ 51, 61 ] ], "normalized": [] }, { "id": "NCT03082573_inc_T4", "type": "Temporal", "text": [ "at the time of participation" ], "offsets": [ [ 69, 97 ] ], "normalized": [] }, { "id": "NCT03082573_inc_T5", "type": "Reference_point", "text": [ "participation" ], "offsets": [ [ 84, 97 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03082573_inc_R1", "type": "Has_index", "arg1_id": "NCT03082573_inc_T4", "arg2_id": "NCT03082573_inc_T5", "normalized": [] }, { "id": "NCT03082573_inc_R2", "type": "Has_value", "arg1_id": "NCT03082573_inc_T2", "arg2_id": "NCT03082573_inc_T3", "normalized": [] }, { "id": "NCT03082573_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03082573_inc_T2", "arg2_id": "NCT03082573_inc_T4", "normalized": [] } ]

[ { "id": "NCT03083197_exc_text", "type": "exclusion", "text": [ "Known hypersensitivity to tetracycline, doxycycline or azithromycin\nAdministration of doxycycline, azithromycin, chloramphenicol, rifampicin, or tetracycline during the preceding 7 days\nPregnancy or breast-feeding\nPatients with myasthenia gravis or systemic lupus erythematosus\nPatients with an established infection (diagnostic test required) e.g. acute malaria, dengue, leptospirosis, typhoid, Japanese encephalitis etc.\nCurrent TB or TB treatment in = 6 months (contain active antibiotics against Orientia spp.)\nCurrent HAART use for HIV, long term use of immunosuppressants (e.g. steroids, chemotherapy, TNF-inhibitors and related agents)\nPatients with severe disease whom the clinical team feel their condition necessitates the need for additional scrub typhus treatment beyond the allocated antibiotic treatment assigned at randomization (e.g. IV chloramphenicol and/or PO/NG rifampicin)\n" ], "offsets": [ [ 0, 894 ] ] } ]

[ { "id": "NCT03083197_exc_T1", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 6, 22 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T2", "type": "Drug", "text": [ "tetracycline" ], "offsets": [ [ 26, 38 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T3", "type": "Drug", "text": [ "doxycycline" ], "offsets": [ [ 40, 51 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T4", "type": "Drug", "text": [ "azithromycin" ], "offsets": [ [ 55, 67 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T5", "type": "Scope", "text": [ "tetracycline, doxycycline or azithromycin" ], "offsets": [ [ 26, 67 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T6", "type": "Drug", "text": [ "doxycycline" ], "offsets": [ [ 86, 97 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T7", "type": "Drug", "text": [ "azithromycin" ], "offsets": [ [ 99, 111 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T8", "type": "Drug", "text": [ "chloramphenicol" ], "offsets": [ [ 113, 128 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T9", "type": "Drug", "text": [ "rifampicin" ], "offsets": [ [ 130, 140 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T10", "type": "Drug", "text": [ "tetracycline" ], "offsets": [ [ 145, 157 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T11", "type": "Temporal", "text": [ "during the preceding 7 days" ], "offsets": [ [ 158, 185 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T12", "type": "Scope", "text": [ "doxycycline, azithromycin, chloramphenicol, rifampicin, or tetracycline" ], "offsets": [ [ 86, 157 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T13", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 186, 195 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T14", "type": "Observation", "text": [ "breast-feeding" ], "offsets": [ [ 199, 213 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T15", "type": "Condition", "text": [ "myasthenia gravis" ], "offsets": [ [ 228, 245 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T16", "type": "Condition", "text": [ "systemic lupus erythematosus" ], "offsets": [ [ 249, 277 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T17", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 307, 316 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T18", "type": "Procedure", "text": [ "diagnostic test" ], "offsets": [ [ 318, 333 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T19", "type": "Condition", "text": [ "acute malaria" ], "offsets": [ [ 349, 362 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T20", "type": "Condition", "text": [ "dengue" ], "offsets": [ [ 364, 370 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T21", "type": "Condition", "text": [ "leptospirosis" ], "offsets": [ [ 372, 385 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T22", "type": "Condition", "text": [ "typhoid" ], "offsets": [ [ 387, 394 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T23", "type": "Condition", "text": [ "Japanese encephalitis" ], "offsets": [ [ 396, 417 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T24", "type": "Scope", "text": [ "acute malaria, dengue, leptospirosis, typhoid, Japanese encephalitis" ], "offsets": [ [ 349, 417 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T25", "type": "Condition", "text": [ "TB" ], "offsets": [ [ 437, 439 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T26", "type": "Procedure", "text": [ "TB treatment" ], "offsets": [ [ 437, 449 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T27", "type": "Temporal", "text": [ "in = 6 months" ], "offsets": [ [ 450, 463 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T28", "type": "Procedure", "text": [ "HAART" ], "offsets": [ [ 523, 528 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T29", "type": "Condition", "text": [ "HIV" ], "offsets": [ [ 537, 540 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T30", "type": "Multiplier", "text": [ "long term use" ], "offsets": [ [ 542, 555 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T31", "type": "Drug", "text": [ "immunosuppressants" ], "offsets": [ [ 559, 577 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T32", "type": "Drug", "text": [ "steroids" ], "offsets": [ [ 584, 592 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T33", "type": "Drug", "text": [ "chemotherapy" ], "offsets": [ [ 594, 606 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T34", "type": "Drug", "text": [ "TNF-inhibitors" ], "offsets": [ [ 608, 622 ] ], "normalized": [] }, { "id": "NCT03083197_exc_T35", "type": "Scope", "text": [ "steroids, chemotherapy, TNF-inhibitors" ], "offsets": [ [ 584, 622 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03083197_exc_R1", "type": "Has_scope", "arg1_id": "NCT03083197_exc_T1", "arg2_id": "NCT03083197_exc_T5", "normalized": [] }, { "id": "NCT03083197_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03083197_exc_T12", "arg2_id": "NCT03083197_exc_T11", "normalized": [] }, { "id": "NCT03083197_exc_R3", "type": "AND", "arg1_id": "NCT03083197_exc_T17", "arg2_id": "NCT03083197_exc_T18", "normalized": [] }, { "id": "NCT03083197_exc_R4", "type": "Subsumes", "arg1_id": "NCT03083197_exc_T17", "arg2_id": "NCT03083197_exc_T24", "normalized": [] }, { "id": "NCT03083197_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03083197_exc_T26", "arg2_id": "NCT03083197_exc_T27", "normalized": [] }, { "id": "NCT03083197_exc_R6", "type": "AND", "arg1_id": "NCT03083197_exc_T28", "arg2_id": "NCT03083197_exc_T29", "normalized": [] }, { "id": "NCT03083197_exc_R7", "type": "Has_multiplier", "arg1_id": "NCT03083197_exc_T31", "arg2_id": "NCT03083197_exc_T30", "normalized": [] }, { "id": "NCT03083197_exc_R8", "type": "Subsumes", "arg1_id": "NCT03083197_exc_T31", "arg2_id": "NCT03083197_exc_T35", "normalized": [] } ]

[ { "id": "NCT03083197_inc_text", "type": "inclusion", "text": [ "Age = 15 years old\nHospitalization with acute undifferentiated fever (temperature > 37.5 C, tympanic) =14 days or patients admitted to hospital with a history of fever = 14 days who subsequently develop fever within 24 hours of admission\nClinically suspected scrub typhus: defined as acute undifferentiated fever with no clear focus of infection and negative malaria blood smear and/or negative malaria RDT. Patients may have one, none, or a combination of other clinical findings such as eschar, rash, lymphadenopathy, headache, myalgia, cough, nausea and abdominal discomfort.\nA positive scrub typhus RDT (Scrub Typhus IgM RDT, InBios International, Seattle, WA, USA) and/or positive PCR-based detection of O. tsutsugamushi DNA from the admission blood sample\nWritten informed consent and/or, written informed assent as required\nAble to take oral medication\n" ], "offsets": [ [ 0, 860 ] ] } ]

[ { "id": "NCT03083197_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T3", "type": "Procedure", "text": [ "Hospitalization" ], "offsets": [ [ 19, 34 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T4", "type": "Condition", "text": [ "acute undifferentiated fever" ], "offsets": [ [ 40, 68 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T5", "type": "Measurement", "text": [ "temperature" ], "offsets": [ [ 70, 81 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T6", "type": "Value", "text": [ "> 37.5 C" ], "offsets": [ [ 82, 90 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T7", "type": "Condition", "text": [ "tympanic" ], "offsets": [ [ 92, 100 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T8", "type": "Scope", "text": [ "temperature > 37.5 C, tympanic" ], "offsets": [ [ 70, 100 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T9", "type": "Multiplier", "text": [ "=14 days" ], "offsets": [ [ 102, 110 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T10", "type": "Observation", "text": [ "history" ], "offsets": [ [ 151, 158 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T11", "type": "Condition", "text": [ "fever" ], "offsets": [ [ 162, 167 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T12", "type": "Multiplier", "text": [ "= 14 days" ], "offsets": [ [ 168, 177 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T13", "type": "Condition", "text": [ "fever" ], "offsets": [ [ 203, 208 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T14", "type": "Temporal", "text": [ "within 24 hours of admission" ], "offsets": [ [ 209, 237 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T15", "type": "Procedure", "text": [ "admitted to hospital" ], "offsets": [ [ 123, 143 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T16", "type": "Reference_point", "text": [ "admission" ], "offsets": [ [ 228, 237 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T2", "type": "Value", "text": [ "= 15 years old" ], "offsets": [ [ 4, 18 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T17", "type": "Scope", "text": [ "history of fever = 14 days who subsequently develop fever within 24 hours of admission" ], "offsets": [ [ 151, 237 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T18", "type": "Condition", "text": [ "scrub typhus" ], "offsets": [ [ 259, 271 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T19", "type": "Condition", "text": [ "acute undifferentiated fever" ], "offsets": [ [ 284, 312 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T20", "type": "Condition", "text": [ "focus of infection" ], "offsets": [ [ 327, 345 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T21", "type": "Negation", "text": [ "no clear" ], "offsets": [ [ 318, 326 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T22", "type": "Value", "text": [ "negative" ], "offsets": [ [ 350, 358 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T23", "type": "Measurement", "text": [ "malaria blood smear" ], "offsets": [ [ 359, 378 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T24", "type": "Value", "text": [ "negative" ], "offsets": [ [ 386, 394 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T25", "type": "Measurement", "text": [ "malaria RDT" ], "offsets": [ [ 395, 406 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T26", "type": "Multiplier", "text": [ "one" ], "offsets": [ [ 426, 429 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T27", "type": "Multiplier", "text": [ "none" ], "offsets": [ [ 431, 435 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T28", "type": "Multiplier", "text": [ "a combination of" ], "offsets": [ [ 440, 456 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T29", "type": "Scope", "text": [ "one, none, or a combination of" ], "offsets": [ [ 426, 456 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T30", "type": "Condition", "text": [ "eschar" ], "offsets": [ [ 489, 495 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T31", "type": "Condition", "text": [ "rash" ], "offsets": [ [ 497, 501 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T32", "type": "Condition", "text": [ "lymphadenopathy" ], "offsets": [ [ 503, 518 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T33", "type": "Condition", "text": [ "headache" ], "offsets": [ [ 520, 528 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T34", "type": "Condition", "text": [ "myalgia" ], "offsets": [ [ 530, 537 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T35", "type": "Condition", "text": [ "cough" ], "offsets": [ [ 539, 544 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T36", "type": "Condition", "text": [ "nausea" ], "offsets": [ [ 546, 552 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T37", "type": "Condition", "text": [ "abdominal discomfort" ], "offsets": [ [ 557, 577 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T38", "type": "Scope", "text": [ "eschar, rash, lymphadenopathy, headache, myalgia, cough, nausea and abdominal discomfort" ], "offsets": [ [ 489, 577 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T39", "type": "Scope", "text": [ "one, none, or a combination of other clinical findings such as eschar, rash, lymphadenopathy, headache, myalgia, cough, nausea and abdominal discomfort" ], "offsets": [ [ 426, 577 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T40", "type": "Scope", "text": [ "acute undifferentiated fever with no clear focus of infection and negative malaria blood smear and/or negative malaria RDT" ], "offsets": [ [ 284, 406 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T41", "type": "Measurement", "text": [ "scrub typhus RDT" ], "offsets": [ [ 590, 606 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T42", "type": "Value", "text": [ "positive" ], "offsets": [ [ 581, 589 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T43", "type": "Procedure", "text": [ "Scrub Typhus IgM RDT" ], "offsets": [ [ 608, 628 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T44", "type": "Value", "text": [ "positive" ], "offsets": [ [ 677, 685 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T45", "type": "Procedure", "text": [ "PCR" ], "offsets": [ [ 686, 689 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T46", "type": "Qualifier", "text": [ "O. tsutsugamushi DNA" ], "offsets": [ [ 709, 729 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T47", "type": "Qualifier", "text": [ "admission blood sample" ], "offsets": [ [ 739, 761 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T48", "type": "Observation", "text": [ "Written informed consent" ], "offsets": [ [ 762, 786 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T49", "type": "Observation", "text": [ "written informed assent" ], "offsets": [ [ 795, 818 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T50", "type": "Observation", "text": [ "Able to take oral medication" ], "offsets": [ [ 831, 859 ] ], "normalized": [] }, { "id": "NCT03083197_inc_T51", "type": "Drug", "text": [ "oral medication" ], "offsets": [ [ 844, 859 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03083197_inc_R2", "type": "Has_value", "arg1_id": "NCT03083197_inc_T5", "arg2_id": "NCT03083197_inc_T6", "normalized": [] }, { "id": "NCT03083197_inc_R3", "type": "Has_scope", "arg1_id": "NCT03083197_inc_T4", "arg2_id": "NCT03083197_inc_T8", "normalized": [] }, { "id": "NCT03083197_inc_R4", "type": "AND", "arg1_id": "NCT03083197_inc_T3", "arg2_id": "NCT03083197_inc_T4", "normalized": [] }, { "id": "NCT03083197_inc_R5", "type": "Has_multiplier", "arg1_id": "NCT03083197_inc_T3", "arg2_id": "NCT03083197_inc_T9", "normalized": [] }, { "id": "NCT03083197_inc_R6", "type": "Has_multiplier", "arg1_id": "NCT03083197_inc_T11", "arg2_id": "NCT03083197_inc_T12", "normalized": [] }, { "id": "NCT03083197_inc_R7", "type": "Has_temporal", "arg1_id": "NCT03083197_inc_T11", "arg2_id": "NCT03083197_inc_T10", "normalized": [] }, { "id": "NCT03083197_inc_R8", "type": "Has_temporal", "arg1_id": "NCT03083197_inc_T13", "arg2_id": "NCT03083197_inc_T14", "normalized": [] }, { "id": "NCT03083197_inc_R9", "type": "Has_index", "arg1_id": "NCT03083197_inc_T14", "arg2_id": "NCT03083197_inc_T16", "normalized": [] }, { "id": "NCT03083197_inc_R1", "type": "Has_value", "arg1_id": "NCT03083197_inc_T1", "arg2_id": "NCT03083197_inc_T2", "normalized": [] }, { "id": "NCT03083197_inc_R10", "type": "Has_scope", "arg1_id": "NCT03083197_inc_T15", "arg2_id": "NCT03083197_inc_T17", "normalized": [] }, { "id": "NCT03083197_inc_R11", "type": "Has_negation", "arg1_id": "NCT03083197_inc_T20", "arg2_id": "NCT03083197_inc_T21", "normalized": [] }, { "id": "NCT03083197_inc_R12", "type": "Has_value", "arg1_id": "NCT03083197_inc_T23", "arg2_id": "NCT03083197_inc_T22", "normalized": [] }, { "id": "NCT03083197_inc_R13", "type": "Has_value", "arg1_id": "NCT03083197_inc_T25", "arg2_id": "NCT03083197_inc_T24", "normalized": [] }, { "id": "NCT03083197_inc_R14", "type": "Has_scope", "arg1_id": "NCT03083197_inc_T38", "arg2_id": "NCT03083197_inc_T29", "normalized": [] }, { "id": "NCT03083197_inc_R15", "type": "Subsumes", "arg1_id": "NCT03083197_inc_T18", "arg2_id": "NCT03083197_inc_T40", "normalized": [] }, { "id": "NCT03083197_inc_R16", "type": "Has_value", "arg1_id": "NCT03083197_inc_T41", "arg2_id": "NCT03083197_inc_T42", "normalized": [] }, { "id": "NCT03083197_inc_R17", "type": "Subsumes", "arg1_id": "NCT03083197_inc_T41", "arg2_id": "NCT03083197_inc_T43", "normalized": [] }, { "id": "NCT03083197_inc_R18", "type": "Has_qualifier", "arg1_id": "NCT03083197_inc_T45", "arg2_id": "NCT03083197_inc_T46", "normalized": [] }, { "id": "NCT03083197_inc_R19", "type": "Has_qualifier", "arg1_id": "NCT03083197_inc_T45", "arg2_id": "NCT03083197_inc_T47", "normalized": [] }, { "id": "NCT03083197_inc_R20", "type": "Has_value", "arg1_id": "NCT03083197_inc_T45", "arg2_id": "NCT03083197_inc_T44", "normalized": [] } ]

[ { "id": "NCT03084588_exc_text", "type": "exclusion", "text": [ "Preoperative renal failure requiring dialysis\nPoorly controlled pulmonary disease (severe asthma or COPD) -Contraindication to regional anesthesia (recent anticoagulant use)\nSleep apnea or morbid obesity with possible sleep apnea\nAllergy to methadone\nSignificant preoperative pain requiring treatment with high doses of opioids (more than 6-8 Norco tablets or equivalence per day) or recent history of opioid abuse\n" ], "offsets": [ [ 0, 415 ] ] } ]

[ { "id": "NCT03084588_exc_T1", "type": "Temporal", "text": [ "Preoperative" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T2", "type": "Condition", "text": [ "renal failure" ], "offsets": [ [ 13, 26 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T3", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 27, 36 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T4", "type": "Procedure", "text": [ "dialysis" ], "offsets": [ [ 37, 45 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T5", "type": "Qualifier", "text": [ "Poorly controlled" ], "offsets": [ [ 46, 63 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T6", "type": "Condition", "text": [ "pulmonary disease" ], "offsets": [ [ 64, 81 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T7", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 83, 89 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T8", "type": "Condition", "text": [ "asthma" ], "offsets": [ [ 90, 96 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T9", "type": "Condition", "text": [ "COPD" ], "offsets": [ [ 100, 104 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T10", "type": "Scope", "text": [ "asthma or COPD" ], "offsets": [ [ 90, 104 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T11", "type": "Scope", "text": [ "severe asthma or COPD" ], "offsets": [ [ 83, 104 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T12", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 107, 123 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T13", "type": "Procedure", "text": [ "regional anesthesia" ], "offsets": [ [ 127, 146 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T14", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 148, 154 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T15", "type": "Drug", "text": [ "anticoagulant" ], "offsets": [ [ 155, 168 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T16", "type": "Scope", "text": [ "Contraindication to regional anesthesia" ], "offsets": [ [ 107, 146 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T17", "type": "Scope", "text": [ "recent anticoagulant" ], "offsets": [ [ 148, 168 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T18", "type": "Condition", "text": [ "Sleep apnea" ], "offsets": [ [ 174, 185 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T19", "type": "Condition", "text": [ "morbid obesity" ], "offsets": [ [ 189, 203 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T20", "type": "Mood", "text": [ "possible" ], "offsets": [ [ 209, 217 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T21", "type": "Condition", "text": [ "sleep apnea" ], "offsets": [ [ 218, 229 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T22", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 230, 237 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T23", "type": "Drug", "text": [ "methadone" ], "offsets": [ [ 241, 250 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T24", "type": "Condition", "text": [ "preoperative pain" ], "offsets": [ [ 263, 280 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T25", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 251, 262 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T26", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 281, 290 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T27", "type": "Multiplier", "text": [ "high doses" ], "offsets": [ [ 306, 316 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T28", "type": "Drug", "text": [ "opioids" ], "offsets": [ [ 320, 327 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T29", "type": "Multiplier", "text": [ " than 6-8 No", "day) or" ], "offsets": [ [ 333, 345 ], [ 376, 383 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T30", "type": "Drug", "text": [ "Norco tablets" ], "offsets": [ [ 343, 356 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T31", "type": "Drug", "text": [ "equivalence" ], "offsets": [ [ 360, 371 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T32", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 384, 390 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T33", "type": "Observation", "text": [ "history" ], "offsets": [ [ 391, 398 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T34", "type": "Condition", "text": [ "opioid abuse" ], "offsets": [ [ 402, 414 ] ], "normalized": [] }, { "id": "NCT03084588_exc_T35", "type": "Scope", "text": [ "more than 6-8 Norco tablets or equivalence per day" ], "offsets": [ [ 329, 379 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03084588_exc_R1", "type": "Has_mood", "arg1_id": "NCT03084588_exc_T4", "arg2_id": "NCT03084588_exc_T3", "normalized": [] }, { "id": "NCT03084588_exc_R2", "type": "AND", "arg1_id": "NCT03084588_exc_T2", "arg2_id": "NCT03084588_exc_T4", "normalized": [] }, { "id": "NCT03084588_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03084588_exc_T2", "arg2_id": "NCT03084588_exc_T1", "normalized": [] }, { "id": "NCT03084588_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03084588_exc_T10", "arg2_id": "NCT03084588_exc_T7", "normalized": [] }, { "id": "NCT03084588_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03084588_exc_T6", "arg2_id": "NCT03084588_exc_T5", "normalized": [] }, { "id": "NCT03084588_exc_R6", "type": "Subsumes", "arg1_id": "NCT03084588_exc_T6", "arg2_id": "NCT03084588_exc_T11", "normalized": [] }, { "id": "NCT03084588_exc_R7", "type": "AND", "arg1_id": "NCT03084588_exc_T12", "arg2_id": "NCT03084588_exc_T13", "normalized": [] }, { "id": "NCT03084588_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03084588_exc_T15", "arg2_id": "NCT03084588_exc_T14", "normalized": [] }, { "id": "NCT03084588_exc_R9", "type": "Subsumes", "arg1_id": "NCT03084588_exc_T16", "arg2_id": "NCT03084588_exc_T17", "normalized": [] }, { "id": "NCT03084588_exc_R10", "type": "Has_mood", "arg1_id": "NCT03084588_exc_T21", "arg2_id": "NCT03084588_exc_T20", "normalized": [] }, { "id": "NCT03084588_exc_R11", "type": "AND", "arg1_id": "NCT03084588_exc_T19", "arg2_id": "NCT03084588_exc_T21", "normalized": [] }, { "id": "NCT03084588_exc_R12", "type": "AND", "arg1_id": "NCT03084588_exc_T22", "arg2_id": "NCT03084588_exc_T23", "normalized": [] }, { "id": "NCT03084588_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT03084588_exc_T24", "arg2_id": "NCT03084588_exc_T25", "normalized": [] }, { "id": "NCT03084588_exc_R14", "type": "Has_multiplier", "arg1_id": "NCT03084588_exc_T28", "arg2_id": "NCT03084588_exc_T27", "normalized": [] }, { "id": "NCT03084588_exc_R15", "type": "Has_mood", "arg1_id": "NCT03084588_exc_T28", "arg2_id": "NCT03084588_exc_T26", "normalized": [] }, { "id": "NCT03084588_exc_R16", "type": "AND", "arg1_id": "NCT03084588_exc_T24", "arg2_id": "NCT03084588_exc_T28", "normalized": [] }, { "id": "NCT03084588_exc_R17", "type": "Subsumes", "arg1_id": "NCT03084588_exc_T30", "arg2_id": "NCT03084588_exc_T31", "normalized": [] }, { "id": "NCT03084588_exc_R18", "type": "Has_multiplier", "arg1_id": "NCT03084588_exc_T30", "arg2_id": "NCT03084588_exc_T29", "normalized": [] }, { "id": "NCT03084588_exc_R19", "type": "Has_temporal", "arg1_id": "NCT03084588_exc_T34", "arg2_id": "NCT03084588_exc_T33", "normalized": [] }, { "id": "NCT03084588_exc_R20", "type": "Has_temporal", "arg1_id": "NCT03084588_exc_T34", "arg2_id": "NCT03084588_exc_T32", "normalized": [] }, { "id": "NCT03084588_exc_R21", "type": "Subsumes", "arg1_id": "NCT03084588_exc_T27", "arg2_id": "NCT03084588_exc_T35", "normalized": [] } ]

[ { "id": "NCT03084588_inc_text", "type": "inclusion", "text": [ "All patients presenting for elective shoulder arthroscopic procedures will be eligible for enrollment.\n" ], "offsets": [ [ 0, 103 ] ] } ]

[ { "id": "NCT03084588_inc_T1", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 28, 36 ] ], "normalized": [] }, { "id": "NCT03084588_inc_T2", "type": "Procedure", "text": [ "shoulder arthroscopic procedures" ], "offsets": [ [ 37, 69 ] ], "normalized": [] } ]

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[ { "id": "NCT03084588_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03084588_inc_T2", "arg2_id": "NCT03084588_inc_T1", "normalized": [] } ]

[ { "id": "NCT03088280_exc_text", "type": "exclusion", "text": [ "PRA > 50%\nDSA > 1500 MFI\nRetransplantation\nPatients who are planning to receive mycophenolate instead of everolimus\nPatients who have planning for follow-up in another center\n" ], "offsets": [ [ 0, 175 ] ] } ]

[ { "id": "NCT03088280_exc_T1", "type": "Measurement", "text": [ "PRA" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03088280_exc_T2", "type": "Value", "text": [ "> 50%" ], "offsets": [ [ 4, 9 ] ], "normalized": [] }, { "id": "NCT03088280_exc_T3", "type": "Measurement", "text": [ "DSA" ], "offsets": [ [ 10, 13 ] ], "normalized": [] }, { "id": "NCT03088280_exc_T4", "type": "Value", "text": [ "> 1500 MFI" ], "offsets": [ [ 14, 24 ] ], "normalized": [] }, { "id": "NCT03088280_exc_T5", "type": "Condition", "text": [ "Retransplantation" ], "offsets": [ [ 25, 42 ] ], "normalized": [] }, { "id": "NCT03088280_exc_T6", "type": "Mood", "text": [ "planning to" ], "offsets": [ [ 60, 71 ] ], "normalized": [] }, { "id": "NCT03088280_exc_T7", "type": "Drug", "text": [ "mycophenolate" ], "offsets": [ [ 80, 93 ] ], "normalized": [] }, { "id": "NCT03088280_exc_T8", "type": "Negation", "text": [ "instead of" ], "offsets": [ [ 94, 104 ] ], "normalized": [] }, { "id": "NCT03088280_exc_T9", "type": "Drug", "text": [ "everolimus" ], "offsets": [ [ 105, 115 ] ], "normalized": [] }, { "id": "NCT03088280_exc_T10", "type": "Mood", "text": [ "planning for" ], "offsets": [ [ 134, 146 ] ], "normalized": [] }, { "id": "NCT03088280_exc_T11", "type": "Procedure", "text": [ "follow-up" ], "offsets": [ [ 147, 156 ] ], "normalized": [] }, { "id": "NCT03088280_exc_T12", "type": "Visit", "text": [ "another center" ], "offsets": [ [ 160, 174 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03088280_exc_R1", "type": "Has_value", "arg1_id": "NCT03088280_exc_T1", "arg2_id": "NCT03088280_exc_T2", "normalized": [] }, { "id": "NCT03088280_exc_R2", "type": "Has_value", "arg1_id": "NCT03088280_exc_T3", "arg2_id": "NCT03088280_exc_T4", "normalized": [] }, { "id": "NCT03088280_exc_R3", "type": "Has_negation", "arg1_id": "NCT03088280_exc_T9", "arg2_id": "NCT03088280_exc_T8", "normalized": [] }, { "id": "NCT03088280_exc_R4", "type": "AND", "arg1_id": "NCT03088280_exc_T7", "arg2_id": "NCT03088280_exc_T9", "normalized": [] }, { "id": "NCT03088280_exc_R5", "type": "Has_mood", "arg1_id": "NCT03088280_exc_T7", "arg2_id": "NCT03088280_exc_T6", "normalized": [] }, { "id": "NCT03088280_exc_R6", "type": "AND", "arg1_id": "NCT03088280_exc_T11", "arg2_id": "NCT03088280_exc_T12", "normalized": [] }, { "id": "NCT03088280_exc_R7", "type": "Has_mood", "arg1_id": "NCT03088280_exc_T11", "arg2_id": "NCT03088280_exc_T10", "normalized": [] } ]

[ { "id": "NCT03088280_inc_text", "type": "inclusion", "text": [ "Primary kidney transplant recipients, adults\n" ], "offsets": [ [ 0, 45 ] ] } ]

[ { "id": "NCT03088280_inc_T1", "type": "Procedure", "text": [ "kidney transplant" ], "offsets": [ [ 8, 25 ] ], "normalized": [] }, { "id": "NCT03088280_inc_T2", "type": "Qualifier", "text": [ "Primary" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03088280_inc_T3", "type": "Person", "text": [ "adults" ], "offsets": [ [ 38, 44 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03088280_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03088280_inc_T1", "arg2_id": "NCT03088280_inc_T2", "normalized": [] } ]

[ { "id": "NCT03088904_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT03088904_inc_text", "type": "inclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

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[ { "id": "NCT03089086_exc_text", "type": "exclusion", "text": [ "Previous anaphylaxis following any component of Bexsero vaccine\nPrevious receipt of meningococcal B vaccine (Bexsero)\nKnown pregnancy\n" ], "offsets": [ [ 0, 134 ] ] } ]

[ { "id": "NCT03089086_exc_T1", "type": "Condition", "text": [ "anaphylaxis" ], "offsets": [ [ 9, 20 ] ], "normalized": [] }, { "id": "NCT03089086_exc_T2", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03089086_exc_T3", "type": "Drug", "text": [ "Bexsero vaccine" ], "offsets": [ [ 48, 63 ] ], "normalized": [] }, { "id": "NCT03089086_exc_T4", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 64, 72 ] ], "normalized": [] }, { "id": "NCT03089086_exc_T5", "type": "Drug", "text": [ "meningococcal B vaccine" ], "offsets": [ [ 84, 107 ] ], "normalized": [] }, { "id": "NCT03089086_exc_T6", "type": "Drug", "text": [ "Bexsero" ], "offsets": [ [ 109, 116 ] ], "normalized": [] }, { "id": "NCT03089086_exc_T7", "type": "Condition", "text": [ "pregnancy" ], "offsets": [ [ 124, 133 ] ], "normalized": [] } ]

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[ { "id": "NCT03089086_exc_R1", "type": "AND", "arg1_id": "NCT03089086_exc_T1", "arg2_id": "NCT03089086_exc_T3", "normalized": [] }, { "id": "NCT03089086_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03089086_exc_T1", "arg2_id": "NCT03089086_exc_T2", "normalized": [] }, { "id": "NCT03089086_exc_R3", "type": "Subsumes", "arg1_id": "NCT03089086_exc_T5", "arg2_id": "NCT03089086_exc_T6", "normalized": [] }, { "id": "NCT03089086_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03089086_exc_T5", "arg2_id": "NCT03089086_exc_T4", "normalized": [] } ]

[ { "id": "NCT03089086_inc_text", "type": "inclusion", "text": [ "South Australian secondary school students in years 10, 11, and 12 in 2017\nWritten parental consent for those under the age of 18\nWritten student consent assent for those under the age of 18 (or if 18 years old and older consent for themselves)\nAvailable at school for at least the first pharyngeal swab and willing to comply with study procedures\n" ], "offsets": [ [ 0, 348 ] ] } ]

[ { "id": "NCT03089086_inc_T1", "type": "Observation", "text": [ "secondary school students" ], "offsets": [ [ 17, 42 ] ], "normalized": [] }, { "id": "NCT03089086_inc_T2", "type": "Qualifier", "text": [ "years 10" ], "offsets": [ [ 46, 54 ] ], "normalized": [] }, { "id": "NCT03089086_inc_T3", "type": "Qualifier", "text": [ "years", "11" ], "offsets": [ [ 46, 51 ], [ 56, 58 ] ], "normalized": [] }, { "id": "NCT03089086_inc_T4", "type": "Qualifier", "text": [ "years", "12" ], "offsets": [ [ 46, 51 ], [ 64, 66 ] ], "normalized": [] }, { "id": "NCT03089086_inc_T5", "type": "Temporal", "text": [ "in 2017" ], "offsets": [ [ 67, 74 ] ], "normalized": [] }, { "id": "NCT03089086_inc_T6", "type": "Scope", "text": [ "years 10, 11, and 12" ], "offsets": [ [ 46, 66 ] ], "normalized": [] }, { "id": "NCT03089086_inc_T7", "type": "Visit", "text": [ "South Australian" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT03089086_inc_T10", "type": "Multiplier", "text": [ "first" ], "offsets": [ [ 282, 287 ] ], "normalized": [] }, { "id": "NCT03089086_inc_T11", "type": "Procedure", "text": [ "pharyngeal swab" ], "offsets": [ [ 288, 303 ] ], "normalized": [] }, { "id": "NCT03089086_inc_T12", "type": "Mood", "text": [ "willing to" ], "offsets": [ [ 308, 318 ] ], "normalized": [] }, { "id": "NCT03089086_inc_T13", "type": "Observation", "text": [ "comply with study procedures" ], "offsets": [ [ 319, 347 ] ], "normalized": [] } ]

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[ { "id": "NCT03089086_inc_R1", "type": "Has_scope", "arg1_id": "NCT03089086_inc_T1", "arg2_id": "NCT03089086_inc_T6", "normalized": [] }, { "id": "NCT03089086_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03089086_inc_T1", "arg2_id": "NCT03089086_inc_T5", "normalized": [] }, { "id": "NCT03089086_inc_R3", "type": "Has_mood", "arg1_id": "NCT03089086_inc_T13", "arg2_id": "NCT03089086_inc_T12", "normalized": [] }, { "id": "NCT03089086_inc_R4", "type": "Has_multiplier", "arg1_id": "NCT03089086_inc_T11", "arg2_id": "NCT03089086_inc_T10", "normalized": [] } ]

[ { "id": "NCT03091881_exc_text", "type": "exclusion", "text": [ "Contraindications for spinal anesthesia (like bleeding diathesis or regional infection at site of neuroaxial block)\nKnown allergy to Granisetron or local anaesthetic (heavy bupivacaine, Marcaine Spinal 0.5% Heavy, 5mg/ml, AstraZeneca ampule)\nPregnancy induced hypertension\nCongenital or rheumatic heart diseases\nAntepartum haemorrhage\nFetal destress or gestational age < 36 week\n" ], "offsets": [ [ 0, 379 ] ] } ]

[ { "id": "NCT03091881_exc_T1", "type": "Condition", "text": [ "Contraindications" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T2", "type": "Procedure", "text": [ "spinal anesthesia" ], "offsets": [ [ 22, 39 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T3", "type": "Condition", "text": [ "bleeding diathesis" ], "offsets": [ [ 46, 64 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T4", "type": "Condition", "text": [ "regional infection" ], "offsets": [ [ 68, 86 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T5", "type": "Qualifier", "text": [ "site of neuroaxial block" ], "offsets": [ [ 90, 114 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T6", "type": "Scope", "text": [ "bleeding diathesis or regional infection" ], "offsets": [ [ 46, 86 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T7", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 122, 129 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T8", "type": "Drug", "text": [ "Granisetron" ], "offsets": [ [ 133, 144 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T9", "type": "Drug", "text": [ "local anaesthetic" ], "offsets": [ [ 148, 165 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T10", "type": "Drug", "text": [ "heavy bupivacaine" ], "offsets": [ [ 167, 184 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T11", "type": "Drug", "text": [ "Marcaine Spinal 0.5% Heavy" ], "offsets": [ [ 186, 212 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T12", "type": "Qualifier", "text": [ "5mg/ml" ], "offsets": [ [ 214, 220 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T13", "type": "Qualifier", "text": [ "AstraZeneca ampule" ], "offsets": [ [ 222, 240 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T14", "type": "Scope", "text": [ "heavy bupivacaine, Marcaine Spinal 0.5% Heavy, 5mg/ml, AstraZeneca ampule" ], "offsets": [ [ 167, 240 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T15", "type": "Scope", "text": [ "Granisetron or local anaesthetic (heavy bupivacaine, Marcaine Spinal 0.5% Heavy, 5mg/ml, AstraZeneca ampule)" ], "offsets": [ [ 133, 241 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T16", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 242, 251 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T17", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 260, 272 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T18", "type": "Qualifier", "text": [ "Pregnancy induced" ], "offsets": [ [ 242, 259 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T19", "type": "Qualifier", "text": [ "Congenital" ], "offsets": [ [ 273, 283 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T20", "type": "Qualifier", "text": [ "rheumatic" ], "offsets": [ [ 287, 296 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T21", "type": "Condition", "text": [ "heart diseases" ], "offsets": [ [ 297, 311 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T22", "type": "Scope", "text": [ "Congenital or rheumatic" ], "offsets": [ [ 273, 296 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T23", "type": "Condition", "text": [ "Antepartum haemorrhage" ], "offsets": [ [ 312, 334 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T24", "type": "Condition", "text": [ "Fetal destress" ], "offsets": [ [ 335, 349 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T25", "type": "Measurement", "text": [ "gestational age" ], "offsets": [ [ 353, 368 ] ], "normalized": [] }, { "id": "NCT03091881_exc_T26", "type": "Value", "text": [ "< 36 week" ], "offsets": [ [ 369, 378 ] ], "normalized": [] } ]

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[ { "id": "NCT03091881_exc_R1", "type": "AND", "arg1_id": "NCT03091881_exc_T1", "arg2_id": "NCT03091881_exc_T2", "normalized": [] }, { "id": "NCT03091881_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03091881_exc_T6", "arg2_id": "NCT03091881_exc_T5", "normalized": [] }, { "id": "NCT03091881_exc_R3", "type": "Subsumes", "arg1_id": "NCT03091881_exc_T10", "arg2_id": "NCT03091881_exc_T11", "normalized": [] }, { "id": "NCT03091881_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03091881_exc_T11", "arg2_id": "NCT03091881_exc_T12", "normalized": [] }, { "id": "NCT03091881_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03091881_exc_T11", "arg2_id": "NCT03091881_exc_T13", "normalized": [] }, { "id": "NCT03091881_exc_R6", "type": "Subsumes", "arg1_id": "NCT03091881_exc_T9", "arg2_id": "NCT03091881_exc_T14", "normalized": [] }, { "id": "NCT03091881_exc_R7", "type": "Has_scope", "arg1_id": "NCT03091881_exc_T7", "arg2_id": "NCT03091881_exc_T15", "normalized": [] }, { "id": "NCT03091881_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03091881_exc_T17", "arg2_id": "NCT03091881_exc_T18", "normalized": [] }, { "id": "NCT03091881_exc_R10", "type": "Has_scope", "arg1_id": "NCT03091881_exc_T21", "arg2_id": "NCT03091881_exc_T22", "normalized": [] }, { "id": "NCT03091881_exc_R11", "type": "Has_value", "arg1_id": "NCT03091881_exc_T25", "arg2_id": "NCT03091881_exc_T26", "normalized": [] } ]

[ { "id": "NCT03091881_inc_text", "type": "inclusion", "text": [ "Type I diabetic patients\nParturients presented for Cesarean section\n" ], "offsets": [ [ 0, 68 ] ] } ]

[ { "id": "NCT03091881_inc_T1", "type": "Condition", "text": [ "Type I diabetic" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT03091881_inc_T2", "type": "Condition", "text": [ "Parturients" ], "offsets": [ [ 25, 36 ] ], "normalized": [] }, { "id": "NCT03091881_inc_T3", "type": "Measurement", "text": [ "Cesarean section" ], "offsets": [ [ 51, 67 ] ], "normalized": [] } ]

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[ { "id": "NCT03096613_exc_text", "type": "exclusion", "text": [ "Acute heart failure or acute exacerbation of chronic heart failure within the past 2 weeks.\nScheduled cardiac resynchronization therapy or heart transplantation.\nHistory of malignant tumor or life expectancy under 12 months.\nAlready on medications that may affect thyroid function (L-T4, carbimazole, propylthiouracil, amiodarone, lithium).\nPregnancy and lactation period.\nParticipation in another clinical trial within the past 30 days.\nContraindication or intolerance to evidence-based therapy for CHF, such as beta-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker.\nKnown hypersensitivity to the trial treatment(s) or diluents (when applicable), including placebo or other comparator drug(s).\nUntreated adrenal insufficiency.\nUntreated pituitary insufficiency.\nUntreated thyrotoxicosis.\nTreatment with levothyroxine must not be initiated in patients with acute myocardial infarction, acute myocarditis, or acute pancarditis.\nSevere renal dysfunction (eGFR=30 ml/min/1.73m2).\nSignificant hepatic impairment (Serum GPT > 120 U/L).\nAny disorder which, in the opinion of the investigator, might jeopardise subject's safety or compliance with the protocol.\n" ], "offsets": [ [ 0, 1186 ] ] } ]

[ { "id": "NCT03096613_exc_T1", "type": "Condition", "text": [ "Acute heart failure" ], "offsets": [ [ 0, 19 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T2", "type": "Condition", "text": [ "exacerbation" ], "offsets": [ [ 29, 41 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T3", "type": "Qualifier", "text": [ "acute" ], "offsets": [ [ 23, 28 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T4", "type": "Condition", "text": [ "chronic heart failure" ], "offsets": [ [ 45, 66 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T5", "type": "Temporal", "text": [ "within the past 2 weeks" ], "offsets": [ [ 67, 90 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T6", "type": "Scope", "text": [ "Acute heart failure or acute exacerbation of chronic heart failure" ], "offsets": [ [ 0, 66 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T7", "type": "Procedure", "text": [ "cardiac resynchronization therapy" ], "offsets": [ [ 102, 135 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T8", "type": "Procedure", "text": [ "heart transplantation" ], "offsets": [ [ 139, 160 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T9", "type": "Condition", "text": [ "malignant tumor" ], "offsets": [ [ 173, 188 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T10", "type": "Person", "text": [ "life expectancy" ], "offsets": [ [ 192, 207 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T11", "type": "Value", "text": [ "under 12 months" ], "offsets": [ [ 208, 223 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T12", "type": "Drug", "text": [ "medications" ], "offsets": [ [ 236, 247 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T13", "type": "Measurement", "text": [ "thyroid function" ], "offsets": [ [ 264, 280 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T14", "type": "Value", "text": [ "affect" ], "offsets": [ [ 257, 263 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T15", "type": "Drug", "text": [ "L-T4" ], "offsets": [ [ 282, 286 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T16", "type": "Drug", "text": [ "carbimazole" ], "offsets": [ [ 288, 299 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T17", "type": "Drug", "text": [ "propylthiouracil" ], "offsets": [ [ 301, 317 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T18", "type": "Drug", "text": [ "amiodarone" ], "offsets": [ [ 319, 329 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T19", "type": "Drug", "text": [ "lithium" ], "offsets": [ [ 331, 338 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T20", "type": "Scope", "text": [ "L-T4, carbimazole, propylthiouracil, amiodarone, lithium" ], "offsets": [ [ 282, 338 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T21", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 341, 350 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T22", "type": "Condition", "text": [ "lactation period" ], "offsets": [ [ 355, 371 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T24", "type": "Condition", "text": [ "Contraindication" ], "offsets": [ [ 438, 454 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T25", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 458, 469 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T26", "type": "Procedure", "text": [ "evidence-based therapy" ], "offsets": [ [ 473, 495 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T27", "type": "Condition", "text": [ "CHF" ], "offsets": [ [ 500, 503 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T28", "type": "Drug", "text": [ "beta-blocker" ], "offsets": [ [ 513, 525 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T29", "type": "Drug", "text": [ "angiotensin-converting enzyme inhibitor" ], "offsets": [ [ 527, 566 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T30", "type": "Drug", "text": [ "angiotensin receptor blocker" ], "offsets": [ [ 570, 598 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T31", "type": "Scope", "text": [ "beta-blocker, angiotensin-converting enzyme inhibitor or angiotensin receptor blocker" ], "offsets": [ [ 513, 598 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T32", "type": "Scope", "text": [ "Contraindication or intolerance" ], "offsets": [ [ 438, 469 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T33", "type": "Scope", "text": [ "Contraindication or intolerance to evidence-based therapy for CHF" ], "offsets": [ [ 438, 503 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T34", "type": "Procedure", "text": [ "trial treatment(s)" ], "offsets": [ [ 630, 648 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T35", "type": "Drug", "text": [ "reatm", "s (when" ], "offsets": [ [ 637, 642 ], [ 659, 666 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T36", "type": "Scope", "text": [ "trial treatment(s) or diluents" ], "offsets": [ [ 630, 660 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T37", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 606, 622 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T38", "type": "Drug", "text": [ "placebo" ], "offsets": [ [ 690, 697 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T39", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 701, 706 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T40", "type": "Drug", "text": [ "comparator drug(s)" ], "offsets": [ [ 707, 725 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T41", "type": "Scope", "text": [ "placebo or other comparator drug(s)" ], "offsets": [ [ 690, 725 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T42", "type": "Scope", "text": [ "hypersensitivity to the trial treatment(s) or diluents" ], "offsets": [ [ 606, 660 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T43", "type": "Condition", "text": [ "adrenal insufficiency" ], "offsets": [ [ 737, 758 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T44", "type": "Qualifier", "text": [ "Untreated" ], "offsets": [ [ 727, 736 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T45", "type": "Condition", "text": [ "pituitary insufficiency" ], "offsets": [ [ 770, 793 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T46", "type": "Qualifier", "text": [ "Untreated" ], "offsets": [ [ 760, 769 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T47", "type": "Condition", "text": [ "thyrotoxicosis" ], "offsets": [ [ 805, 819 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T48", "type": "Qualifier", "text": [ "Untreated" ], "offsets": [ [ 795, 804 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T49", "type": "Drug", "text": [ "levothyroxine" ], "offsets": [ [ 836, 849 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T50", "type": "Condition", "text": [ "acute myocardial infarction" ], "offsets": [ [ 889, 916 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T51", "type": "Negation", "text": [ "not be initiated" ], "offsets": [ [ 855, 871 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T52", "type": "Procedure", "text": [ "Treatment" ], "offsets": [ [ 821, 830 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T53", "type": "Condition", "text": [ "acute myocarditis" ], "offsets": [ [ 918, 935 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T54", "type": "Condition", "text": [ "acute pancarditis" ], "offsets": [ [ 940, 957 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T55", "type": "Scope", "text": [ "acute myocardial infarction, acute myocarditis, or acute pancarditis" ], "offsets": [ [ 889, 957 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T56", "type": "Condition", "text": [ "renal dysfunction" ], "offsets": [ [ 966, 983 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T57", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 959, 965 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T58", "type": "Measurement", "text": [ "eGFR" ], "offsets": [ [ 985, 989 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T59", "type": "Value", "text": [ "=30 ml/min/1.73m2" ], "offsets": [ [ 989, 1006 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T60", "type": "Scope", "text": [ "eGFR=30 ml/min/1.73m2" ], "offsets": [ [ 985, 1006 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T61", "type": "Scope", "text": [ "Severe renal dysfunction" ], "offsets": [ [ 959, 983 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T62", "type": "Condition", "text": [ "hepatic impairment" ], "offsets": [ [ 1021, 1039 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T63", "type": "Qualifier", "text": [ "Significant" ], "offsets": [ [ 1009, 1020 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T64", "type": "Measurement", "text": [ "Serum GPT" ], "offsets": [ [ 1041, 1050 ] ], "normalized": [] }, { "id": "NCT03096613_exc_T65", "type": "Value", "text": [ "> 120 U/L" ], "offsets": [ [ 1051, 1060 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03096613_exc_R1", "type": "AND", "arg1_id": "NCT03096613_exc_T4", "arg2_id": "NCT03096613_exc_T2", "normalized": [] }, { "id": "NCT03096613_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03096613_exc_T2", "arg2_id": "NCT03096613_exc_T3", "normalized": [] }, { "id": "NCT03096613_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03096613_exc_T6", "arg2_id": "NCT03096613_exc_T5", "normalized": [] }, { "id": "NCT03096613_exc_R4", "type": "Has_value", "arg1_id": "NCT03096613_exc_T10", "arg2_id": "NCT03096613_exc_T11", "normalized": [] }, { "id": "NCT03096613_exc_R5", "type": "Has_value", "arg1_id": "NCT03096613_exc_T13", "arg2_id": "NCT03096613_exc_T14", "normalized": [] }, { "id": "NCT03096613_exc_R6", "type": "Subsumes", "arg1_id": "NCT03096613_exc_T12", "arg2_id": "NCT03096613_exc_T20", "normalized": [] }, { "id": "NCT03096613_exc_R7", "type": "AND", "arg1_id": "NCT03096613_exc_T12", "arg2_id": "NCT03096613_exc_T13", "normalized": [] }, { "id": "NCT03096613_exc_R8", "type": "AND", "arg1_id": "NCT03096613_exc_T21", "arg2_id": "NCT03096613_exc_T22", "normalized": [] }, { "id": "NCT03096613_exc_R9", "type": "AND", "arg1_id": "NCT03096613_exc_T26", "arg2_id": "NCT03096613_exc_T27", "normalized": [] }, { "id": "NCT03096613_exc_R10", "type": "AND", "arg1_id": "NCT03096613_exc_T32", "arg2_id": "NCT03096613_exc_T26", "normalized": [] }, { "id": "NCT03096613_exc_R11", "type": "Subsumes", "arg1_id": "NCT03096613_exc_T33", "arg2_id": "NCT03096613_exc_T31", "normalized": [] }, { "id": "NCT03096613_exc_R12", "type": "Has_scope", "arg1_id": "NCT03096613_exc_T37", "arg2_id": "NCT03096613_exc_T36", "normalized": [] }, { "id": "NCT03096613_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT03096613_exc_T40", "arg2_id": "NCT03096613_exc_T39", "normalized": [] }, { "id": "NCT03096613_exc_R14", "type": "Subsumes", "arg1_id": "NCT03096613_exc_T42", "arg2_id": "NCT03096613_exc_T41", "normalized": [] }, { "id": "NCT03096613_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT03096613_exc_T43", "arg2_id": "NCT03096613_exc_T44", "normalized": [] }, { "id": "NCT03096613_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT03096613_exc_T45", "arg2_id": "NCT03096613_exc_T46", "normalized": [] }, { "id": "NCT03096613_exc_R17", "type": "Has_qualifier", "arg1_id": "NCT03096613_exc_T47", "arg2_id": "NCT03096613_exc_T48", "normalized": [] }, { "id": "NCT03096613_exc_R18", "type": "AND", "arg1_id": "NCT03096613_exc_T52", "arg2_id": "NCT03096613_exc_T49", "normalized": [] }, { "id": "NCT03096613_exc_R19", "type": "Has_negation", "arg1_id": "NCT03096613_exc_T52", "arg2_id": "NCT03096613_exc_T51", "normalized": [] }, { "id": "NCT03096613_exc_R20", "type": "AND", "arg1_id": "NCT03096613_exc_T55", "arg2_id": "NCT03096613_exc_T52", "normalized": [] }, { "id": "NCT03096613_exc_R21", "type": "Has_qualifier", "arg1_id": "NCT03096613_exc_T56", "arg2_id": "NCT03096613_exc_T57", "normalized": [] }, { "id": "NCT03096613_exc_R22", "type": "Has_value", "arg1_id": "NCT03096613_exc_T58", "arg2_id": "NCT03096613_exc_T59", "normalized": [] }, { "id": "NCT03096613_exc_R23", "type": "Subsumes", "arg1_id": "NCT03096613_exc_T61", "arg2_id": "NCT03096613_exc_T60", "normalized": [] }, { "id": "NCT03096613_exc_R24", "type": "Has_qualifier", "arg1_id": "NCT03096613_exc_T62", "arg2_id": "NCT03096613_exc_T63", "normalized": [] } ]

[ { "id": "NCT03096613_inc_text", "type": "inclusion", "text": [ "Aged 18 years or older, male or female.\nSystolic heart failure with New York Heart Association (NYHA) class II-III.\nLeft ventricular ejection fraction (LVEF) less than 40% by echocardiography during screening and randomization.\nSCH (TSH: upper limits of normal (ULN) -10mIU/L, and FT4 level within reference range).\nHaving received standard HF therapy for at least 2 weeks, having reached target dose or max tolerable dose.\nProvided informed consent.\n" ], "offsets": [ [ 0, 451 ] ] } ]

[ { "id": "NCT03096613_inc_T1", "type": "Value", "text": [ "18 years or older" ], "offsets": [ [ 5, 22 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T2", "type": "Person", "text": [ "Aged" ], "offsets": [ [ 0, 4 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T3", "type": "Person", "text": [ "male" ], "offsets": [ [ 24, 28 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T4", "type": "Person", "text": [ "female" ], "offsets": [ [ 32, 38 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T5", "type": "Condition", "text": [ "Systolic heart failure" ], "offsets": [ [ 40, 62 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T6", "type": "Measurement", "text": [ "New York Heart Association (NYHA)" ], "offsets": [ [ 68, 101 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T7", "type": "Value", "text": [ "class II-III" ], "offsets": [ [ 102, 114 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T8", "type": "Measurement", "text": [ "Left ventricular ejection fraction (LVEF)" ], "offsets": [ [ 116, 157 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T9", "type": "Value", "text": [ "less than 40%" ], "offsets": [ [ 158, 171 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T10", "type": "Procedure", "text": [ "echocardiography" ], "offsets": [ [ 175, 191 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T11", "type": "Temporal", "text": [ "during screening and randomization" ], "offsets": [ [ 192, 226 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T12", "type": "Condition", "text": [ "SCH" ], "offsets": [ [ 228, 231 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T13", "type": "Measurement", "text": [ "TSH" ], "offsets": [ [ 233, 236 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T14", "type": "Value", "text": [ "upper limits of normal (ULN) -10mIU/L" ], "offsets": [ [ 238, 275 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T15", "type": "Measurement", "text": [ "FT4 level" ], "offsets": [ [ 281, 290 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T16", "type": "Value", "text": [ "within reference range" ], "offsets": [ [ 291, 313 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T17", "type": "Scope", "text": [ "TSH: upper limits of normal (ULN) -10mIU/L, and FT4 level within reference range" ], "offsets": [ [ 233, 313 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T18", "type": "Procedure", "text": [ "standard HF therapy" ], "offsets": [ [ 332, 351 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T19", "type": "Temporal", "text": [ "for at least 2 weeks" ], "offsets": [ [ 352, 372 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T20", "type": "Multiplier", "text": [ "target dose" ], "offsets": [ [ 389, 400 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T21", "type": "Multiplier", "text": [ "max tolerable dose" ], "offsets": [ [ 404, 422 ] ], "normalized": [] }, { "id": "NCT03096613_inc_T22", "type": "Scope", "text": [ "target dose or max tolerable dose" ], "offsets": [ [ 389, 422 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03096613_inc_R1", "type": "Has_value", "arg1_id": "NCT03096613_inc_T2", "arg2_id": "NCT03096613_inc_T1", "normalized": [] }, { "id": "NCT03096613_inc_R2", "type": "Has_value", "arg1_id": "NCT03096613_inc_T6", "arg2_id": "NCT03096613_inc_T7", "normalized": [] }, { "id": "NCT03096613_inc_R3", "type": "AND", "arg1_id": "NCT03096613_inc_T5", "arg2_id": "NCT03096613_inc_T6", "normalized": [] }, { "id": "NCT03096613_inc_R4", "type": "Has_temporal", "arg1_id": "NCT03096613_inc_T10", "arg2_id": "NCT03096613_inc_T11", "normalized": [] }, { "id": "NCT03096613_inc_R5", "type": "AND", "arg1_id": "NCT03096613_inc_T10", "arg2_id": "NCT03096613_inc_T8", "normalized": [] }, { "id": "NCT03096613_inc_R6", "type": "Has_value", "arg1_id": "NCT03096613_inc_T8", "arg2_id": "NCT03096613_inc_T9", "normalized": [] }, { "id": "NCT03096613_inc_R7", "type": "Has_value", "arg1_id": "NCT03096613_inc_T15", "arg2_id": "NCT03096613_inc_T16", "normalized": [] }, { "id": "NCT03096613_inc_R8", "type": "Has_value", "arg1_id": "NCT03096613_inc_T13", "arg2_id": "NCT03096613_inc_T14", "normalized": [] }, { "id": "NCT03096613_inc_R9", "type": "Subsumes", "arg1_id": "NCT03096613_inc_T12", "arg2_id": "NCT03096613_inc_T17", "normalized": [] }, { "id": "NCT03096613_inc_R10", "type": "Has_temporal", "arg1_id": "NCT03096613_inc_T18", "arg2_id": "NCT03096613_inc_T19", "normalized": [] }, { "id": "NCT03096613_inc_R11", "type": "Has_scope", "arg1_id": "NCT03096613_inc_T18", "arg2_id": "NCT03096613_inc_T22", "normalized": [] } ]

[ { "id": "NCT03097068_exc_text", "type": "exclusion", "text": [ "History of anti-vascular endothelial growth factor treatment in the past 12 months\nAny diabetic macular edema treatment in the past 4 months\nHeart attack, stroke, transient ischemic attack or acute congestive heart failure within 4 months\n" ], "offsets": [ [ 0, 239 ] ] } ]

[ { "id": "NCT03097068_exc_T1", "type": "Drug", "text": [ "anti-vascular endothelial growth factor" ], "offsets": [ [ 11, 50 ] ], "normalized": [] }, { "id": "NCT03097068_exc_T2", "type": "Temporal", "text": [ "in the past 12 months" ], "offsets": [ [ 61, 82 ] ], "normalized": [] }, { "id": "NCT03097068_exc_T3", "type": "Condition", "text": [ "diabetic macular edema" ], "offsets": [ [ 87, 109 ] ], "normalized": [] }, { "id": "NCT03097068_exc_T4", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 110, 119 ] ], "normalized": [] }, { "id": "NCT03097068_exc_T5", "type": "Temporal", "text": [ "in the past 4 months" ], "offsets": [ [ 120, 140 ] ], "normalized": [] }, { "id": "NCT03097068_exc_T6", "type": "Condition", "text": [ "Heart attack" ], "offsets": [ [ 141, 153 ] ], "normalized": [] }, { "id": "NCT03097068_exc_T7", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 155, 161 ] ], "normalized": [] }, { "id": "NCT03097068_exc_T8", "type": "Condition", "text": [ "transient ischemic attack" ], "offsets": [ [ 163, 188 ] ], "normalized": [] }, { "id": "NCT03097068_exc_T9", "type": "Condition", "text": [ "acute congestive heart failure" ], "offsets": [ [ 192, 222 ] ], "normalized": [] }, { "id": "NCT03097068_exc_T10", "type": "Temporal", "text": [ "within 4 months" ], "offsets": [ [ 223, 238 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03097068_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03097068_exc_T1", "arg2_id": "NCT03097068_exc_T2", "normalized": [] }, { "id": "NCT03097068_exc_R2", "type": "AND", "arg1_id": "NCT03097068_exc_T4", "arg2_id": "NCT03097068_exc_T3", "normalized": [] }, { "id": "NCT03097068_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03097068_exc_T4", "arg2_id": "NCT03097068_exc_T5", "normalized": [] }, { "id": "NCT03097068_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03097068_exc_T9", "arg2_id": "NCT03097068_exc_T10", "normalized": [] } ]

[ { "id": "NCT03097068_inc_text", "type": "inclusion", "text": [ "Diagnosis of diabetes mellitus\nBest corrected visual acuity 20/32 - 20/320\nDiabetic macular edema involving the center of the macula\nOptical coherence tomography central subfield thickness of at least 250 microns\n" ], "offsets": [ [ 0, 213 ] ] } ]

[ { "id": "NCT03097068_inc_T1", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 13, 30 ] ], "normalized": [] }, { "id": "NCT03097068_inc_T2", "type": "Measurement", "text": [ "Best corrected visual acuity" ], "offsets": [ [ 31, 59 ] ], "normalized": [] }, { "id": "NCT03097068_inc_T3", "type": "Value", "text": [ "20/32 - 20/320" ], "offsets": [ [ 60, 74 ] ], "normalized": [] }, { "id": "NCT03097068_inc_T4", "type": "Condition", "text": [ "Diabetic macular edema" ], "offsets": [ [ 75, 97 ] ], "normalized": [] }, { "id": "NCT03097068_inc_T5", "type": "Qualifier", "text": [ "center of the macula" ], "offsets": [ [ 112, 132 ] ], "normalized": [] }, { "id": "NCT03097068_inc_T6", "type": "Measurement", "text": [ "Optical coherence tomography central subfield thickness" ], "offsets": [ [ 133, 188 ] ], "normalized": [] }, { "id": "NCT03097068_inc_T7", "type": "Value", "text": [ "at least 250 microns" ], "offsets": [ [ 192, 212 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03097068_inc_R1", "type": "Has_value", "arg1_id": "NCT03097068_inc_T2", "arg2_id": "NCT03097068_inc_T3", "normalized": [] }, { "id": "NCT03097068_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03097068_inc_T4", "arg2_id": "NCT03097068_inc_T5", "normalized": [] }, { "id": "NCT03097068_inc_R3", "type": "Has_value", "arg1_id": "NCT03097068_inc_T6", "arg2_id": "NCT03097068_inc_T7", "normalized": [] } ]

[ { "id": "NCT03099408_exc_text", "type": "exclusion", "text": [ "Presence of another vaginal infection or STD\nAllergy to metronidazole\nPregnant or nursing\nUse of oral or intravaginal antibiotics within the past 2 weeks\nHIV or other chronic disease\nInability to keep return appointments\nContraindications for Lactobacillus Vaginal Suppositories(those without sexual history)\n" ], "offsets": [ [ 0, 309 ] ] } ]

[ { "id": "NCT03099408_exc_T1", "type": "Condition", "text": [ "vaginal infection" ], "offsets": [ [ 20, 37 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T2", "type": "Qualifier", "text": [ "another" ], "offsets": [ [ 12, 19 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T3", "type": "Condition", "text": [ "STD" ], "offsets": [ [ 41, 44 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T4", "type": "Scope", "text": [ "vaginal infection or STD" ], "offsets": [ [ 20, 44 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T5", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 45, 52 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T6", "type": "Drug", "text": [ "metronidazole" ], "offsets": [ [ 56, 69 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T7", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 70, 78 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T8", "type": "Condition", "text": [ "nursing" ], "offsets": [ [ 82, 89 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T9", "type": "Drug", "text": [ "intravaginal antibiotics" ], "offsets": [ [ 105, 129 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T10", "type": "Drug", "text": [ "l or", "ibiotics wi" ], "offsets": [ [ 100, 104 ], [ 121, 132 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T11", "type": "Temporal", "text": [ "within the past 2 weeks" ], "offsets": [ [ 130, 153 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T12", "type": "Scope", "text": [ "oral or intravaginal antibiotics" ], "offsets": [ [ 97, 129 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T13", "type": "Condition", "text": [ "HIV" ], "offsets": [ [ 154, 157 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T14", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 161, 166 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T15", "type": "Condition", "text": [ "chronic disease" ], "offsets": [ [ 167, 182 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T16", "type": "Observation", "text": [ "Inability to keep return appointments" ], "offsets": [ [ 183, 220 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T17", "type": "Condition", "text": [ "Contraindications" ], "offsets": [ [ 221, 238 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T18", "type": "Drug", "text": [ "Lactobacillus Vaginal Suppositories" ], "offsets": [ [ 243, 278 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T19", "type": "Negation", "text": [ "without" ], "offsets": [ [ 285, 292 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T20", "type": "Observation", "text": [ "sexual history" ], "offsets": [ [ 293, 307 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T21", "type": "Scope", "text": [ "without sexual history" ], "offsets": [ [ 285, 307 ] ], "normalized": [] }, { "id": "NCT03099408_exc_T22", "type": "Scope", "text": [ "Contraindications for Lactobacillus Vaginal Suppositories" ], "offsets": [ [ 221, 278 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03099408_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03099408_exc_T4", "arg2_id": "NCT03099408_exc_T2", "normalized": [] }, { "id": "NCT03099408_exc_R2", "type": "AND", "arg1_id": "NCT03099408_exc_T5", "arg2_id": "NCT03099408_exc_T6", "normalized": [] }, { "id": "NCT03099408_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03099408_exc_T12", "arg2_id": "NCT03099408_exc_T11", "normalized": [] }, { "id": "NCT03099408_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03099408_exc_T15", "arg2_id": "NCT03099408_exc_T14", "normalized": [] }, { "id": "NCT03099408_exc_R5", "type": "Has_negation", "arg1_id": "NCT03099408_exc_T20", "arg2_id": "NCT03099408_exc_T19", "normalized": [] }, { "id": "NCT03099408_exc_R6", "type": "AND", "arg1_id": "NCT03099408_exc_T17", "arg2_id": "NCT03099408_exc_T18", "normalized": [] }, { "id": "NCT03099408_exc_R7", "type": "Subsumes", "arg1_id": "NCT03099408_exc_T22", "arg2_id": "NCT03099408_exc_T21", "normalized": [] } ]

[ { "id": "NCT03099408_inc_text", "type": "inclusion", "text": [ "Women be at least 18 years of age\nHave symptoms of vaginal odor and or/discharge\nMeet the clinical (Amsel) criteria for BV\nWilling to participate in research\n" ], "offsets": [ [ 0, 158 ] ] } ]

[ { "id": "NCT03099408_inc_T1", "type": "Person", "text": [ "Women" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03099408_inc_T2", "type": "Value", "text": [ "at least 18 years" ], "offsets": [ [ 9, 26 ] ], "normalized": [] }, { "id": "NCT03099408_inc_T3", "type": "Person", "text": [ "age" ], "offsets": [ [ 30, 33 ] ], "normalized": [] }, { "id": "NCT03099408_inc_T4", "type": "Mood", "text": [ "symptoms of" ], "offsets": [ [ 39, 50 ] ], "normalized": [] }, { "id": "NCT03099408_inc_T5", "type": "Condition", "text": [ "vaginal odor" ], "offsets": [ [ 51, 63 ] ], "normalized": [] }, { "id": "NCT03099408_inc_T6", "type": "Condition", "text": [ "aginal", "ischarge" ], "offsets": [ [ 52, 58 ], [ 72, 80 ] ], "normalized": [] }, { "id": "NCT03099408_inc_T7", "type": "Scope", "text": [ "vaginal odor and or/discharge" ], "offsets": [ [ 51, 80 ] ], "normalized": [] }, { "id": "NCT03099408_inc_T8", "type": "Condition", "text": [ "BV" ], "offsets": [ [ 120, 122 ] ], "normalized": [] }, { "id": "NCT03099408_inc_T9", "type": "Qualifier", "text": [ "iteria f", "inical (" ], "offsets": [ [ 109, 117 ], [ 92, 100 ] ], "normalized": [] }, { "id": "NCT03099408_inc_T10", "type": "Qualifier", "text": [ "sel)", "iteria f" ], "offsets": [ [ 102, 106 ], [ 109, 117 ] ], "normalized": [] }, { "id": "NCT03099408_inc_T11", "type": "Scope", "text": [ "clinical (Amsel) criteria" ], "offsets": [ [ 90, 115 ] ], "normalized": [] }, { "id": "NCT03099408_inc_T12", "type": "Observation", "text": [ "participate in research" ], "offsets": [ [ 134, 157 ] ], "normalized": [] }, { "id": "NCT03099408_inc_T13", "type": "Mood", "text": [ "Willing to" ], "offsets": [ [ 123, 133 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03099408_inc_R1", "type": "Has_value", "arg1_id": "NCT03099408_inc_T3", "arg2_id": "NCT03099408_inc_T2", "normalized": [] }, { "id": "NCT03099408_inc_R2", "type": "Has_mood", "arg1_id": "NCT03099408_inc_T7", "arg2_id": "NCT03099408_inc_T4", "normalized": [] }, { "id": "NCT03099408_inc_R3", "type": "Subsumes", "arg1_id": "NCT03099408_inc_T9", "arg2_id": "NCT03099408_inc_T10", "normalized": [] }, { "id": "NCT03099408_inc_R4", "type": "Has_scope", "arg1_id": "NCT03099408_inc_T8", "arg2_id": "NCT03099408_inc_T11", "normalized": [] }, { "id": "NCT03099408_inc_R5", "type": "Has_mood", "arg1_id": "NCT03099408_inc_T12", "arg2_id": "NCT03099408_inc_T13", "normalized": [] } ]

[ { "id": "NCT03099863_exc_text", "type": "exclusion", "text": [ "Surgeries that include: intradetrusor Botox, vaginal mesh excision, and fistula repair\nPregnancy\nHistory of nephrolithiasis\nAllergy to study medications\nCongenital urogenital anomaly\nNeurogenic bladder\n" ], "offsets": [ [ 0, 202 ] ] } ]

[ { "id": "NCT03099863_exc_T1", "type": "Drug", "text": [ "Botox" ], "offsets": [ [ 38, 43 ] ], "normalized": [] }, { "id": "NCT03099863_exc_T2", "type": "Qualifier", "text": [ "intradetrusor" ], "offsets": [ [ 24, 37 ] ], "normalized": [] }, { "id": "NCT03099863_exc_T3", "type": "Procedure", "text": [ "vaginal mesh excision" ], "offsets": [ [ 45, 66 ] ], "normalized": [] }, { "id": "NCT03099863_exc_T4", "type": "Device", "text": [ "vaginal mesh" ], "offsets": [ [ 45, 57 ] ], "normalized": [] }, { "id": "NCT03099863_exc_T5", "type": "Procedure", "text": [ "fistula repair" ], "offsets": [ [ 72, 86 ] ], "normalized": [] }, { "id": "NCT03099863_exc_T6", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 87, 96 ] ], "normalized": [] }, { "id": "NCT03099863_exc_T7", "type": "Condition", "text": [ "nephrolithiasis" ], "offsets": [ [ 108, 123 ] ], "normalized": [] }, { "id": "NCT03099863_exc_T8", "type": "Observation", "text": [ "History" ], "offsets": [ [ 97, 104 ] ], "normalized": [] }, { "id": "NCT03099863_exc_T9", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 124, 131 ] ], "normalized": [] }, { "id": "NCT03099863_exc_T10", "type": "Drug", "text": [ "study medications" ], "offsets": [ [ 135, 152 ] ], "normalized": [] }, { "id": "NCT03099863_exc_T11", "type": "Qualifier", "text": [ "Congenital" ], "offsets": [ [ 153, 163 ] ], "normalized": [] }, { "id": "NCT03099863_exc_T12", "type": "Condition", "text": [ "urogenital anomaly" ], "offsets": [ [ 164, 182 ] ], "normalized": [] }, { "id": "NCT03099863_exc_T13", "type": "Condition", "text": [ "Neurogenic bladder" ], "offsets": [ [ 183, 201 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03099863_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03099863_exc_T1", "arg2_id": "NCT03099863_exc_T2", "normalized": [] }, { "id": "NCT03099863_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03099863_exc_T7", "arg2_id": "NCT03099863_exc_T8", "normalized": [] }, { "id": "NCT03099863_exc_R4", "type": "AND", "arg1_id": "NCT03099863_exc_T9", "arg2_id": "NCT03099863_exc_T10", "normalized": [] }, { "id": "NCT03099863_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03099863_exc_T12", "arg2_id": "NCT03099863_exc_T11", "normalized": [] } ]

[ { "id": "NCT03099863_inc_text", "type": "inclusion", "text": [ "Adult women at least 18 years of age\nElective Female Pelvic Medicine and Reconstructive Surgery or Gynecologic Minimally Invasive surgeries including hysterectomy, suburethral sling, and pelvic organ prolapse repair that require cystoscopy.\n" ], "offsets": [ [ 0, 241 ] ] } ]

[ { "id": "NCT03099863_inc_T1", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T2", "type": "Person", "text": [ "women" ], "offsets": [ [ 6, 11 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T3", "type": "Value", "text": [ "at least 18 years" ], "offsets": [ [ 12, 29 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T4", "type": "Person", "text": [ "age" ], "offsets": [ [ 33, 36 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T5", "type": "Qualifier", "text": [ "Elective" ], "offsets": [ [ 37, 45 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T6", "type": "Qualifier", "text": [ "Female Pelvic" ], "offsets": [ [ 46, 59 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T7", "type": "Procedure", "text": [ "Reconstructive Surgery" ], "offsets": [ [ 73, 95 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T8", "type": "Drug", "text": [ "Medicine" ], "offsets": [ [ 60, 68 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T9", "type": "Scope", "text": [ "Medicine and Reconstructive Surgery" ], "offsets": [ [ 60, 95 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T10", "type": "Qualifier", "text": [ "Gynecologic" ], "offsets": [ [ 99, 110 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T11", "type": "Qualifier", "text": [ "Minimally Invasive" ], "offsets": [ [ 111, 129 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T12", "type": "Procedure", "text": [ "surgeries" ], "offsets": [ [ 130, 139 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T13", "type": "Scope", "text": [ "Gynecologic Minimally Invasive surgeries" ], "offsets": [ [ 99, 139 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T14", "type": "Procedure", "text": [ "hysterectomy" ], "offsets": [ [ 150, 162 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T15", "type": "Procedure", "text": [ "suburethral sling" ], "offsets": [ [ 164, 181 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T16", "type": "Procedure", "text": [ "pelvic organ prolapse repair" ], "offsets": [ [ 187, 215 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T17", "type": "Procedure", "text": [ "cystoscopy" ], "offsets": [ [ 229, 239 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T18", "type": "Mood", "text": [ "require" ], "offsets": [ [ 221, 228 ] ], "normalized": [] }, { "id": "NCT03099863_inc_T19", "type": "Scope", "text": [ "Gynecologic Minimally Invasive surgeries including hysterectomy, suburethral sling, and pelvic organ prolapse repair" ], "offsets": [ [ 99, 215 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03099863_inc_R1", "type": "Has_value", "arg1_id": "NCT03099863_inc_T4", "arg2_id": "NCT03099863_inc_T3", "normalized": [] }, { "id": "NCT03099863_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03099863_inc_T9", "arg2_id": "NCT03099863_inc_T6", "normalized": [] }, { "id": "NCT03099863_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03099863_inc_T9", "arg2_id": "NCT03099863_inc_T5", "normalized": [] }, { "id": "NCT03099863_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03099863_inc_T12", "arg2_id": "NCT03099863_inc_T11", "normalized": [] }, { "id": "NCT03099863_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03099863_inc_T12", "arg2_id": "NCT03099863_inc_T10", "normalized": [] }, { "id": "NCT03099863_inc_R6", "type": "Has_mood", "arg1_id": "NCT03099863_inc_T17", "arg2_id": "NCT03099863_inc_T18", "normalized": [] }, { "id": "NCT03099863_inc_R7", "type": "AND", "arg1_id": "NCT03099863_inc_T19", "arg2_id": "NCT03099863_inc_T17", "normalized": [] } ]

[ { "id": "NCT03100513_exc_text", "type": "exclusion", "text": [ "Patients with active GIT bleeding.\nPatients with history of bowel obstruction, perforation.\nPatients with history of allergy to PEG.\nTreatment with rifaximin or neomycin in the previous 7 days.\nPatients with major psychiatric illness.\nPatients receiving benzodiazepines and narcotics.\nPatients with compromised renal.\nPatients receiving medications highly bound to plasma proteins eg. Warfarin.\nPregnant or lactating women.\nFulminant hepatic failure.\n" ], "offsets": [ [ 0, 451 ] ] } ]

[ { "id": "NCT03100513_exc_T1", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 14, 20 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T2", "type": "Condition", "text": [ "GIT bleeding" ], "offsets": [ [ 21, 33 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T3", "type": "Condition", "text": [ "bowel obstruction" ], "offsets": [ [ 60, 77 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T4", "type": "Condition", "text": [ "owel", "erforation." ], "offsets": [ [ 61, 65 ], [ 80, 91 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T5", "type": "Observation", "text": [ "history" ], "offsets": [ [ 49, 56 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T6", "type": "Scope", "text": [ "bowel obstruction, perforation" ], "offsets": [ [ 60, 90 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T7", "type": "Observation", "text": [ "history" ], "offsets": [ [ 106, 113 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T8", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 117, 124 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T9", "type": "Drug", "text": [ "PEG" ], "offsets": [ [ 128, 131 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T10", "type": "Drug", "text": [ "rifaximin" ], "offsets": [ [ 148, 157 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T11", "type": "Drug", "text": [ "neomycin" ], "offsets": [ [ 161, 169 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T12", "type": "Temporal", "text": [ "in the previous 7 days" ], "offsets": [ [ 170, 192 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T13", "type": "Scope", "text": [ "rifaximin or neomycin" ], "offsets": [ [ 148, 169 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T14", "type": "Condition", "text": [ "major psychiatric illness" ], "offsets": [ [ 208, 233 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T15", "type": "Drug", "text": [ "benzodiazepines" ], "offsets": [ [ 254, 269 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T16", "type": "Drug", "text": [ "narcotics" ], "offsets": [ [ 274, 283 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T17", "type": "Condition", "text": [ "compromised renal" ], "offsets": [ [ 299, 316 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T18", "type": "Drug", "text": [ "medications highly bound to plasma proteins" ], "offsets": [ [ 337, 380 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T19", "type": "Drug", "text": [ "Warfarin" ], "offsets": [ [ 385, 393 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T20", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 395, 403 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T21", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 407, 416 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T22", "type": "Person", "text": [ "women" ], "offsets": [ [ 417, 422 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T23", "type": "Condition", "text": [ "hepatic failure" ], "offsets": [ [ 434, 449 ] ], "normalized": [] }, { "id": "NCT03100513_exc_T24", "type": "Qualifier", "text": [ "Fulminant" ], "offsets": [ [ 424, 433 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03100513_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03100513_exc_T2", "arg2_id": "NCT03100513_exc_T1", "normalized": [] }, { "id": "NCT03100513_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03100513_exc_T6", "arg2_id": "NCT03100513_exc_T5", "normalized": [] }, { "id": "NCT03100513_exc_R3", "type": "AND", "arg1_id": "NCT03100513_exc_T8", "arg2_id": "NCT03100513_exc_T9", "normalized": [] }, { "id": "NCT03100513_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03100513_exc_T8", "arg2_id": "NCT03100513_exc_T7", "normalized": [] }, { "id": "NCT03100513_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03100513_exc_T13", "arg2_id": "NCT03100513_exc_T12", "normalized": [] }, { "id": "NCT03100513_exc_R6", "type": "Subsumes", "arg1_id": "NCT03100513_exc_T18", "arg2_id": "NCT03100513_exc_T19", "normalized": [] }, { "id": "NCT03100513_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03100513_exc_T23", "arg2_id": "NCT03100513_exc_T24", "normalized": [] } ]

[ { "id": "NCT03100513_inc_text", "type": "inclusion", "text": [ "Adult Patients with Overt Hepatic Encephalopathy.\n" ], "offsets": [ [ 0, 50 ] ] } ]

[ { "id": "NCT03100513_inc_T1", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03100513_inc_T2", "type": "Condition", "text": [ "Overt Hepatic Encephalopathy" ], "offsets": [ [ 20, 48 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03103204_exc_text", "type": "exclusion", "text": [ "Systemic diseases (diabetes, renal diseases, rheumatic diseases, osteoporosis and cardiovascular diseases)\nPregnant and lactating women\nHIV/ AIDS\nperiodontal treatment in the last year (before baseline appointment)\nMedication: Immunosuppressive drugs, antibiotics in the past three months (before baseline appointment) )\northodontic appliance\n" ], "offsets": [ [ 0, 343 ] ] } ]

[ { "id": "NCT03103204_exc_T1", "type": "Condition", "text": [ "HIV" ], "offsets": [ [ 136, 139 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T2", "type": "Condition", "text": [ "AIDS" ], "offsets": [ [ 141, 145 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T3", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 107, 115 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T4", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 120, 129 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T5", "type": "Person", "text": [ "women" ], "offsets": [ [ 130, 135 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T6", "type": "Condition", "text": [ "Systemic diseases" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T7", "type": "Procedure", "text": [ "periodontal treatment" ], "offsets": [ [ 146, 167 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T8", "type": "Temporal", "text": [ "in the last year" ], "offsets": [ [ 168, 184 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T9", "type": "Temporal", "text": [ "before baseline appointment" ], "offsets": [ [ 186, 213 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T10", "type": "Procedure", "text": [ "baseline appointment" ], "offsets": [ [ 193, 213 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T11", "type": "Reference_point", "text": [ "baseline appointment" ], "offsets": [ [ 193, 213 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T12", "type": "Drug", "text": [ "Immunosuppressive drugs" ], "offsets": [ [ 227, 250 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T13", "type": "Drug", "text": [ "antibiotics" ], "offsets": [ [ 252, 263 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T14", "type": "Temporal", "text": [ "in the past three months" ], "offsets": [ [ 264, 288 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T15", "type": "Scope", "text": [ "Immunosuppressive drugs, antibiotics" ], "offsets": [ [ 227, 263 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T16", "type": "Temporal", "text": [ "before baseline appointment" ], "offsets": [ [ 290, 317 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T17", "type": "Procedure", "text": [ "baseline appointment" ], "offsets": [ [ 297, 317 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T18", "type": "Reference_point", "text": [ "baseline appointment" ], "offsets": [ [ 297, 317 ] ], "normalized": [] }, { "id": "NCT03103204_exc_T19", "type": "Device", "text": [ "orthodontic appliance" ], "offsets": [ [ 321, 342 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03103204_exc_R1", "type": "Subsumes", "arg1_id": "NCT03103204_exc_T1", "arg2_id": "NCT03103204_exc_T2", "normalized": [] }, { "id": "NCT03103204_exc_R3", "type": "Has_index", "arg1_id": "NCT03103204_exc_T9", "arg2_id": "NCT03103204_exc_T11", "normalized": [] }, { "id": "NCT03103204_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03103204_exc_T7", "arg2_id": "NCT03103204_exc_T8", "normalized": [] }, { "id": "NCT03103204_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03103204_exc_T7", "arg2_id": "NCT03103204_exc_T9", "normalized": [] }, { "id": "NCT03103204_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03103204_exc_T15", "arg2_id": "NCT03103204_exc_T14", "normalized": [] }, { "id": "NCT03103204_exc_R7", "type": "Has_index", "arg1_id": "NCT03103204_exc_T16", "arg2_id": "NCT03103204_exc_T18", "normalized": [] }, { "id": "NCT03103204_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03103204_exc_T15", "arg2_id": "NCT03103204_exc_T16", "normalized": [] } ]

[ { "id": "NCT03103204_inc_text", "type": "inclusion", "text": [ "Moderate to advanced generalized chronic periodontitis\nBody mass index: > 18.5 kg/m2\nMinimum of 12 natural teeth\nSmokers, non-smokers or former-smokers\n" ], "offsets": [ [ 0, 152 ] ] } ]

[ { "id": "NCT03103204_inc_T1", "type": "Qualifier", "text": [ "Moderate to advanced" ], "offsets": [ [ 0, 20 ] ], "normalized": [] }, { "id": "NCT03103204_inc_T2", "type": "Condition", "text": [ "generalized chronic periodontitis" ], "offsets": [ [ 21, 54 ] ], "normalized": [] }, { "id": "NCT03103204_inc_T3", "type": "Measurement", "text": [ "Body mass index" ], "offsets": [ [ 55, 70 ] ], "normalized": [] }, { "id": "NCT03103204_inc_T4", "type": "Value", "text": [ "> 18.5 kg/m2" ], "offsets": [ [ 72, 84 ] ], "normalized": [] }, { "id": "NCT03103204_inc_T5", "type": "Multiplier", "text": [ "Minimum of 12" ], "offsets": [ [ 85, 98 ] ], "normalized": [] }, { "id": "NCT03103204_inc_T6", "type": "Observation", "text": [ "natural teeth" ], "offsets": [ [ 99, 112 ] ], "normalized": [] }, { "id": "NCT03103204_inc_T7", "type": "Condition", "text": [ "Smokers" ], "offsets": [ [ 113, 120 ] ], "normalized": [] }, { "id": "NCT03103204_inc_T8", "type": "Condition", "text": [ "non-smokers" ], "offsets": [ [ 122, 133 ] ], "normalized": [] }, { "id": "NCT03103204_inc_T9", "type": "Condition", "text": [ "former-smokers" ], "offsets": [ [ 137, 151 ] ], "normalized": [] } ]

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[ { "id": "NCT03103204_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03103204_inc_T2", "arg2_id": "NCT03103204_inc_T1", "normalized": [] }, { "id": "NCT03103204_inc_R2", "type": "Has_value", "arg1_id": "NCT03103204_inc_T3", "arg2_id": "NCT03103204_inc_T4", "normalized": [] }, { "id": "NCT03103204_inc_R3", "type": "Has_multiplier", "arg1_id": "NCT03103204_inc_T6", "arg2_id": "NCT03103204_inc_T5", "normalized": [] } ]

[ { "id": "NCT03104816_exc_text", "type": "exclusion", "text": [ "Patients requiring surgery for neoplastic processes\nAllergy to acetaminophen\nLiver dysfunction and elevated Liver Function Tests (LFTs)\nAlcohol or drug dependency\nMental retardation\nLess than 50 kg of weight\nregnant women\nPatients requiring long-acting opioid pain management (including fentanyl patch, oxycontin, etc) for over 3 weeks immediately prior to surgery\n" ], "offsets": [ [ 0, 365 ] ] } ]

[ { "id": "NCT03104816_exc_T1", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 19, 26 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T2", "type": "Condition", "text": [ "neoplastic processes" ], "offsets": [ [ 31, 51 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T3", "type": "Drug", "text": [ "acetaminophen" ], "offsets": [ [ 63, 76 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T4", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 52, 59 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T5", "type": "Condition", "text": [ "Liver dysfunction" ], "offsets": [ [ 77, 94 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T6", "type": "Value", "text": [ "elevated" ], "offsets": [ [ 99, 107 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T7", "type": "Measurement", "text": [ "Liver Function Tests" ], "offsets": [ [ 108, 128 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T8", "type": "Measurement", "text": [ "LFTs" ], "offsets": [ [ 130, 134 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T9", "type": "Condition", "text": [ "drug dependency" ], "offsets": [ [ 147, 162 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T10", "type": "Condition", "text": [ "ohol or", "endency\nMe" ], "offsets": [ [ 139, 146 ], [ 155, 165 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T11", "type": "Condition", "text": [ "Mental retardation" ], "offsets": [ [ 163, 181 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T12", "type": "Value", "text": [ "Less than 50 kg" ], "offsets": [ [ 182, 197 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T13", "type": "Measurement", "text": [ "weight" ], "offsets": [ [ 201, 207 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T14", "type": "Condition", "text": [ "regnant" ], "offsets": [ [ 208, 215 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T15", "type": "Person", "text": [ "women" ], "offsets": [ [ 216, 221 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T16", "type": "Drug", "text": [ "long-acting opioid" ], "offsets": [ [ 241, 259 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T17", "type": "Mood", "text": [ "requiring" ], "offsets": [ [ 231, 240 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T18", "type": "Drug", "text": [ "fentanyl patch" ], "offsets": [ [ 287, 301 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T19", "type": "Drug", "text": [ "oxycontin" ], "offsets": [ [ 303, 312 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T20", "type": "Multiplier", "text": [ "for over 3 weeks" ], "offsets": [ [ 319, 335 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T21", "type": "Temporal", "text": [ "immediately prior to surgery" ], "offsets": [ [ 336, 364 ] ], "normalized": [] }, { "id": "NCT03104816_exc_T22", "type": "Scope", "text": [ "fentanyl patch, oxycontin" ], "offsets": [ [ 287, 312 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03104816_exc_R1", "type": "AND", "arg1_id": "NCT03104816_exc_T1", "arg2_id": "NCT03104816_exc_T2", "normalized": [] }, { "id": "NCT03104816_exc_R2", "type": "AND", "arg1_id": "NCT03104816_exc_T4", "arg2_id": "NCT03104816_exc_T3", "normalized": [] }, { "id": "NCT03104816_exc_R3", "type": "Subsumes", "arg1_id": "NCT03104816_exc_T7", "arg2_id": "NCT03104816_exc_T8", "normalized": [] }, { "id": "NCT03104816_exc_R4", "type": "Has_value", "arg1_id": "NCT03104816_exc_T7", "arg2_id": "NCT03104816_exc_T6", "normalized": [] }, { "id": "NCT03104816_exc_R5", "type": "Has_value", "arg1_id": "NCT03104816_exc_T13", "arg2_id": "NCT03104816_exc_T12", "normalized": [] }, { "id": "NCT03104816_exc_R6", "type": "Has_mood", "arg1_id": "NCT03104816_exc_T16", "arg2_id": "NCT03104816_exc_T17", "normalized": [] }, { "id": "NCT03104816_exc_R7", "type": "Subsumes", "arg1_id": "NCT03104816_exc_T16", "arg2_id": "NCT03104816_exc_T22", "normalized": [] }, { "id": "NCT03104816_exc_R8", "type": "Has_multiplier", "arg1_id": "NCT03104816_exc_T16", "arg2_id": "NCT03104816_exc_T20", "normalized": [] }, { "id": "NCT03104816_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03104816_exc_T16", "arg2_id": "NCT03104816_exc_T21", "normalized": [] } ]

[ { "id": "NCT03104816_inc_text", "type": "inclusion", "text": [ "ASA I-III patients scheduled for elective one or two level minimally invasive lumbar fusions\n" ], "offsets": [ [ 0, 93 ] ] } ]

[ { "id": "NCT03104816_inc_T1", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03104816_inc_T2", "type": "Value", "text": [ "I-III" ], "offsets": [ [ 4, 9 ] ], "normalized": [] }, { "id": "NCT03104816_inc_T3", "type": "Mood", "text": [ "scheduled" ], "offsets": [ [ 19, 28 ] ], "normalized": [] }, { "id": "NCT03104816_inc_T4", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 33, 41 ] ], "normalized": [] }, { "id": "NCT03104816_inc_T5", "type": "Qualifier", "text": [ "two level" ], "offsets": [ [ 49, 58 ] ], "normalized": [] }, { "id": "NCT03104816_inc_T6", "type": "Qualifier", "text": [ "one", "level" ], "offsets": [ [ 42, 45 ], [ 53, 58 ] ], "normalized": [] }, { "id": "NCT03104816_inc_T7", "type": "Procedure", "text": [ "minimally invasive lumbar fusions" ], "offsets": [ [ 59, 92 ] ], "normalized": [] }, { "id": "NCT03104816_inc_T8", "type": "Scope", "text": [ "one or two level" ], "offsets": [ [ 42, 58 ] ], "normalized": [] } ]

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[ { "id": "NCT03104816_inc_R1", "type": "Has_value", "arg1_id": "NCT03104816_inc_T1", "arg2_id": "NCT03104816_inc_T2", "normalized": [] }, { "id": "NCT03104816_inc_R2", "type": "Has_scope", "arg1_id": "NCT03104816_inc_T7", "arg2_id": "NCT03104816_inc_T8", "normalized": [] }, { "id": "NCT03104816_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03104816_inc_T7", "arg2_id": "NCT03104816_inc_T4", "normalized": [] }, { "id": "NCT03104816_inc_R4", "type": "Has_mood", "arg1_id": "NCT03104816_inc_T7", "arg2_id": "NCT03104816_inc_T3", "normalized": [] } ]

[ { "id": "NCT03106389_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

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[]

[ { "id": "NCT03106389_inc_text", "type": "inclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

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[ { "id": "NCT03113253_exc_text", "type": "exclusion", "text": [ "Subjects with a history of hypercoagulopathy, deep vein thrombosis (DVT), pulmonary embolism\nRenal impairment\nSubjects with known hypersensitivity to tranexamic acid\nConsecutive fibrinolytic states to coagulopathy\nHistory of convulsions\n" ], "offsets": [ [ 0, 237 ] ] } ]

[ { "id": "NCT03113253_exc_T1", "type": "Condition", "text": [ "hypercoagulopathy" ], "offsets": [ [ 27, 44 ] ], "normalized": [] }, { "id": "NCT03113253_exc_T2", "type": "Condition", "text": [ "deep vein thrombosis" ], "offsets": [ [ 46, 66 ] ], "normalized": [] }, { "id": "NCT03113253_exc_T3", "type": "Condition", "text": [ "DVT" ], "offsets": [ [ 68, 71 ] ], "normalized": [] }, { "id": "NCT03113253_exc_T4", "type": "Condition", "text": [ "pulmonary embolism" ], "offsets": [ [ 74, 92 ] ], "normalized": [] }, { "id": "NCT03113253_exc_T5", "type": "Observation", "text": [ "history" ], "offsets": [ [ 16, 23 ] ], "normalized": [] }, { "id": "NCT03113253_exc_T6", "type": "Condition", "text": [ "Renal impairment" ], "offsets": [ [ 93, 109 ] ], "normalized": [] }, { "id": "NCT03113253_exc_T7", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 130, 146 ] ], "normalized": [] }, { "id": "NCT03113253_exc_T8", "type": "Drug", "text": [ "tranexamic acid" ], "offsets": [ [ 150, 165 ] ], "normalized": [] }, { "id": "NCT03113253_exc_T9", "type": "Condition", "text": [ "fibrinolytic states" ], "offsets": [ [ 178, 197 ] ], "normalized": [] }, { "id": "NCT03113253_exc_T10", "type": "Condition", "text": [ "coagulopathy" ], "offsets": [ [ 201, 213 ] ], "normalized": [] }, { "id": "NCT03113253_exc_T11", "type": "Observation", "text": [ "History" ], "offsets": [ [ 214, 221 ] ], "normalized": [] }, { "id": "NCT03113253_exc_T12", "type": "Condition", "text": [ "convulsions" ], "offsets": [ [ 225, 236 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03113253_exc_R1", "type": "Subsumes", "arg1_id": "NCT03113253_exc_T2", "arg2_id": "NCT03113253_exc_T3", "normalized": [] }, { "id": "NCT03113253_exc_R2", "type": "AND", "arg1_id": "NCT03113253_exc_T7", "arg2_id": "NCT03113253_exc_T8", "normalized": [] }, { "id": "NCT03113253_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03113253_exc_T12", "arg2_id": "NCT03113253_exc_T11", "normalized": [] } ]

[ { "id": "NCT03113253_inc_text", "type": "inclusion", "text": [ "Subjects undergoing burn excision surgery for standard of care purposes\nMale or female >= 18 years of age\nSubject or subject's medical decision maker agrees to participate in this study and provides informed consent\n" ], "offsets": [ [ 0, 216 ] ] } ]

[ { "id": "NCT03113253_inc_T1", "type": "Procedure", "text": [ "burn excision surgery" ], "offsets": [ [ 20, 41 ] ], "normalized": [] }, { "id": "NCT03113253_inc_T2", "type": "Temporal", "text": [ "undergoing" ], "offsets": [ [ 9, 19 ] ], "normalized": [] }, { "id": "NCT03113253_inc_T3", "type": "Person", "text": [ "Male" ], "offsets": [ [ 72, 76 ] ], "normalized": [] }, { "id": "NCT03113253_inc_T4", "type": "Person", "text": [ "female" ], "offsets": [ [ 80, 86 ] ], "normalized": [] }, { "id": "NCT03113253_inc_T5", "type": "Value", "text": [ ">= 18 years" ], "offsets": [ [ 87, 98 ] ], "normalized": [] }, { "id": "NCT03113253_inc_T6", "type": "Person", "text": [ "age" ], "offsets": [ [ 102, 105 ] ], "normalized": [] } ]

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[ { "id": "NCT03113253_inc_R1", "type": "Has_temporal", "arg1_id": "NCT03113253_inc_T1", "arg2_id": "NCT03113253_inc_T2", "normalized": [] }, { "id": "NCT03113253_inc_R2", "type": "Has_value", "arg1_id": "NCT03113253_inc_T6", "arg2_id": "NCT03113253_inc_T5", "normalized": [] } ]

[ { "id": "NCT03115151_exc_text", "type": "exclusion", "text": [ "Baseline cognitive deficits sufficient to make objective pain self-assessments unreliable in the estimation of the Study Investigators.\nImmunocompromised subject\nCoagulopathy\nSevere liver and renal dysfunction\nPreoperative neurological deficits\nThe dura damage during surgery\nInability to follow directions or comprehend the English language.\nFemales who are pregnant as determined by positive pregnancy test on or before the day of surgery.\nPrisoners.\nPatient refusal to provide informed consent.\nAllergy to amide local anesthetics (lidocaine, bupivacaine, ropivacaine) or opioid (fentanyl).\n" ], "offsets": [ [ 0, 593 ] ] } ]

[ { "id": "NCT03115151_exc_T2", "type": "Condition", "text": [ "Immunocompromised" ], "offsets": [ [ 136, 153 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T3", "type": "Condition", "text": [ "Coagulopathy" ], "offsets": [ [ 162, 174 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T4", "type": "Condition", "text": [ "er an", "function\nPr" ], "offsets": [ [ 185, 190 ], [ 201, 212 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T5", "type": "Condition", "text": [ "renal dysfunction" ], "offsets": [ [ 192, 209 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T6", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 175, 181 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T7", "type": "Scope", "text": [ "liver and renal dysfunction" ], "offsets": [ [ 182, 209 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T8", "type": "Condition", "text": [ "neurological deficits" ], "offsets": [ [ 223, 244 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T9", "type": "Qualifier", "text": [ "Preoperative" ], "offsets": [ [ 210, 222 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T10", "type": "Observation", "text": [ "dura damage" ], "offsets": [ [ 249, 260 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T11", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 268, 275 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T14", "type": "Person", "text": [ "Prisoners" ], "offsets": [ [ 442, 451 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T16", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 498, 505 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T17", "type": "Drug", "text": [ "amide local anesthetics" ], "offsets": [ [ 509, 532 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T18", "type": "Drug", "text": [ "lidocaine" ], "offsets": [ [ 534, 543 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T19", "type": "Drug", "text": [ "bupivacaine" ], "offsets": [ [ 545, 556 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T20", "type": "Drug", "text": [ "ropivacaine" ], "offsets": [ [ 558, 569 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T21", "type": "Drug", "text": [ "opioid" ], "offsets": [ [ 574, 580 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T22", "type": "Drug", "text": [ "fentanyl" ], "offsets": [ [ 582, 590 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T23", "type": "Scope", "text": [ "lidocaine, bupivacaine, ropivacaine" ], "offsets": [ [ 534, 569 ] ], "normalized": [] }, { "id": "NCT03115151_exc_T24", "type": "Scope", "text": [ "amide local anesthetics (lidocaine, bupivacaine, ropivacaine) or opioid (fentanyl)." ], "offsets": [ [ 509, 592 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03115151_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03115151_exc_T7", "arg2_id": "NCT03115151_exc_T6", "normalized": [] }, { "id": "NCT03115151_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03115151_exc_T8", "arg2_id": "NCT03115151_exc_T9", "normalized": [] }, { "id": "NCT03115151_exc_R4", "type": "Subsumes", "arg1_id": "NCT03115151_exc_T17", "arg2_id": "NCT03115151_exc_T23", "normalized": [] }, { "id": "NCT03115151_exc_R5", "type": "Subsumes", "arg1_id": "NCT03115151_exc_T21", "arg2_id": "NCT03115151_exc_T22", "normalized": [] }, { "id": "NCT03115151_exc_R6", "type": "Has_scope", "arg1_id": "NCT03115151_exc_T16", "arg2_id": "NCT03115151_exc_T24", "normalized": [] } ]

[ { "id": "NCT03115151_inc_text", "type": "inclusion", "text": [ "Adult subjects aged 18 years or older\nScheduled for elective posterior lumbar spinal fusion surgery between 1 and 3 levels\n" ], "offsets": [ [ 0, 123 ] ] } ]

[ { "id": "NCT03115151_inc_T1", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03115151_inc_T2", "type": "Person", "text": [ "aged" ], "offsets": [ [ 15, 19 ] ], "normalized": [] }, { "id": "NCT03115151_inc_T3", "type": "Value", "text": [ "18 years or older" ], "offsets": [ [ 20, 37 ] ], "normalized": [] }, { "id": "NCT03115151_inc_T4", "type": "Procedure", "text": [ "posterior lumbar spinal fusion surgery" ], "offsets": [ [ 61, 99 ] ], "normalized": [] }, { "id": "NCT03115151_inc_T5", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 52, 60 ] ], "normalized": [] }, { "id": "NCT03115151_inc_T6", "type": "Mood", "text": [ "Scheduled for" ], "offsets": [ [ 38, 51 ] ], "normalized": [] }, { "id": "NCT03115151_inc_T7", "type": "Qualifier", "text": [ "between 1 and 3 levels" ], "offsets": [ [ 100, 122 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03115151_inc_R1", "type": "Has_value", "arg1_id": "NCT03115151_inc_T2", "arg2_id": "NCT03115151_inc_T3", "normalized": [] }, { "id": "NCT03115151_inc_R2", "type": "AND", "arg1_id": "NCT03115151_inc_T1", "arg2_id": "NCT03115151_inc_T2", "normalized": [] }, { "id": "NCT03115151_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03115151_inc_T4", "arg2_id": "NCT03115151_inc_T5", "normalized": [] }, { "id": "NCT03115151_inc_R4", "type": "Has_mood", "arg1_id": "NCT03115151_inc_T4", "arg2_id": "NCT03115151_inc_T6", "normalized": [] }, { "id": "NCT03115151_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03115151_inc_T4", "arg2_id": "NCT03115151_inc_T7", "normalized": [] } ]

[ { "id": "NCT03115320_exc_text", "type": "exclusion", "text": [ "- Irregular menstrual cycle demanding preparing endometrium with hormones for frozen-thawed embryo\nNo frozen embryos after IVF cycle\nAllergy to Pregnyl® or some of its ingredients in the medication or other contraindications due to Pregnyl®\n" ], "offsets": [ [ 0, 241 ] ] } ]

[ { "id": "NCT03115320_exc_T1", "type": "Condition", "text": [ "Irregular menstrual cycle" ], "offsets": [ [ 2, 27 ] ], "normalized": [] }, { "id": "NCT03115320_exc_T2", "type": "Procedure", "text": [ "preparing endometrium with hormones for frozen-thawed embryo" ], "offsets": [ [ 38, 98 ] ], "normalized": [] }, { "id": "NCT03115320_exc_T3", "type": "Procedure", "text": [ "IVF cycle" ], "offsets": [ [ 123, 132 ] ], "normalized": [] }, { "id": "NCT03115320_exc_T5", "type": "Negation", "text": [ "No" ], "offsets": [ [ 99, 101 ] ], "normalized": [] }, { "id": "NCT03115320_exc_T6", "type": "Observation", "text": [ "frozen embryos" ], "offsets": [ [ 102, 116 ] ], "normalized": [] }, { "id": "NCT03115320_exc_T4", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 133, 140 ] ], "normalized": [] }, { "id": "NCT03115320_exc_T7", "type": "Drug", "text": [ "Pregnyl" ], "offsets": [ [ 144, 151 ] ], "normalized": [] }, { "id": "NCT03115320_exc_T8", "type": "Drug", "text": [ "some of its ingredients" ], "offsets": [ [ 156, 179 ] ], "normalized": [] }, { "id": "NCT03115320_exc_T9", "type": "Scope", "text": [ "Pregnyl® or some of its ingredients" ], "offsets": [ [ 144, 179 ] ], "normalized": [] }, { "id": "NCT03115320_exc_T10", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 207, 224 ] ], "normalized": [] }, { "id": "NCT03115320_exc_T11", "type": "Drug", "text": [ "Pregnyl" ], "offsets": [ [ 232, 239 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03115320_exc_R1", "type": "AND", "arg1_id": "NCT03115320_exc_T1", "arg2_id": "NCT03115320_exc_T2", "normalized": [] }, { "id": "NCT03115320_exc_R2", "type": "Has_negation", "arg1_id": "NCT03115320_exc_T6", "arg2_id": "NCT03115320_exc_T5", "normalized": [] }, { "id": "NCT03115320_exc_R4", "type": "AND", "arg1_id": "NCT03115320_exc_T9", "arg2_id": "NCT03115320_exc_T4", "normalized": [] }, { "id": "NCT03115320_exc_R5", "type": "AND", "arg1_id": "NCT03115320_exc_T10", "arg2_id": "NCT03115320_exc_T11", "normalized": [] } ]

[ { "id": "NCT03115320_inc_text", "type": "inclusion", "text": [ "- Patient with IVF cycle and therefore having frozen-thawed embryos\nRegular menstruation cycle\nPatient's willingness to participate in the study\n" ], "offsets": [ [ 0, 145 ] ] } ]

[ { "id": "NCT03115320_inc_T1", "type": "Procedure", "text": [ "IVF cycle" ], "offsets": [ [ 15, 24 ] ], "normalized": [] }, { "id": "NCT03115320_inc_T2", "type": "Device", "text": [ "frozen-thawed embryos" ], "offsets": [ [ 46, 67 ] ], "normalized": [] }, { "id": "NCT03115320_inc_T3", "type": "Condition", "text": [ "Regular menstruation cycle" ], "offsets": [ [ 68, 94 ] ], "normalized": [] } ]

[]

[]

[]

[ { "id": "NCT03117608_exc_text", "type": "exclusion", "text": [ "Patients incapable to understanding and will;\nPatients participating in previous, concurrent or not, trials (ongoing or completed within three months);\nPatients surgically treated for the same defect within one year;\nPatients affected by malignancy;\nPatients affected by metabolic or thyroid disorders;\nPatients used to alcohol or drug (medication) abuse;\nPatients affected by synovitis;\nVarus or valgus misalignment exceeding 15°;\nBody Mass Index > 40;\nPatients with trauma within 6 months pre-operative.\n" ], "offsets": [ [ 0, 506 ] ] } ]

[ { "id": "NCT03117608_exc_T1", "type": "Observation", "text": [ "incapable to understanding" ], "offsets": [ [ 9, 35 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T2", "type": "Observation", "text": [ "will", "incapable to" ], "offsets": [ [ 40, 44 ], [ 9, 21 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T3", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 72, 80 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T4", "type": "Observation", "text": [ "rials", "articipating in" ], "offsets": [ [ 102, 107 ], [ 56, 71 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T5", "type": "Qualifier", "text": [ "ongoing" ], "offsets": [ [ 109, 116 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T6", "type": "Qualifier", "text": [ "completed" ], "offsets": [ [ 120, 129 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T7", "type": "Temporal", "text": [ "within three months" ], "offsets": [ [ 130, 149 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T8", "type": "Scope", "text": [ "ongoing or completed within three months" ], "offsets": [ [ 109, 149 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T9", "type": "Procedure", "text": [ "surgically treated" ], "offsets": [ [ 161, 179 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T10", "type": "Condition", "text": [ "the same defect" ], "offsets": [ [ 184, 199 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T11", "type": "Temporal", "text": [ "within one year" ], "offsets": [ [ 200, 215 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T12", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 238, 248 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T13", "type": "Condition", "text": [ "bolic or", "rders;\nPa" ], "offsets": [ [ 275, 283 ], [ 296, 305 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T14", "type": "Condition", "text": [ "thyroid disorders" ], "offsets": [ [ 284, 301 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T15", "type": "Condition", "text": [ "ol or d", ";\nPat" ], "offsets": [ [ 325, 332 ], [ 354, 359 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T16", "type": "Condition", "text": [ "(med", ";\nPat" ], "offsets": [ [ 336, 340 ], [ 354, 359 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T17", "type": "Condition", "text": [ "ation) abu", ";\nPat" ], "offsets": [ [ 342, 352 ], [ 354, 359 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T18", "type": "Condition", "text": [ "synovitis" ], "offsets": [ [ 377, 386 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T19", "type": "Condition", "text": [ "valgus misalignment" ], "offsets": [ [ 397, 416 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T20", "type": "Condition", "text": [ "r val", "nment exceed" ], "offsets": [ [ 395, 400 ], [ 411, 423 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T21", "type": "Measurement", "text": [ "valgus misalignment" ], "offsets": [ [ 397, 416 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T22", "type": "Measurement", "text": [ "r val", "nment exceed" ], "offsets": [ [ 395, 400 ], [ 411, 423 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T23", "type": "Value", "text": [ "exceeding 15°" ], "offsets": [ [ 417, 430 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T24", "type": "Measurement", "text": [ "Body Mass Index" ], "offsets": [ [ 432, 447 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T25", "type": "Value", "text": [ "> 40" ], "offsets": [ [ 448, 452 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T26", "type": "Procedure", "text": [ "trauma" ], "offsets": [ [ 468, 474 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T27", "type": "Temporal", "text": [ "within 6 months pre-operative" ], "offsets": [ [ 475, 504 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T28", "type": "Reference_point", "text": [ "pre-operative" ], "offsets": [ [ 491, 504 ] ], "normalized": [] }, { "id": "NCT03117608_exc_T29", "type": "Procedure", "text": [ "operative" ], "offsets": [ [ 495, 504 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03117608_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03117608_exc_T4", "arg2_id": "NCT03117608_exc_T3", "normalized": [] }, { "id": "NCT03117608_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03117608_exc_T6", "arg2_id": "NCT03117608_exc_T7", "normalized": [] }, { "id": "NCT03117608_exc_R3", "type": "Has_scope", "arg1_id": "NCT03117608_exc_T4", "arg2_id": "NCT03117608_exc_T8", "normalized": [] }, { "id": "NCT03117608_exc_R4", "type": "AND", "arg1_id": "NCT03117608_exc_T9", "arg2_id": "NCT03117608_exc_T10", "normalized": [] }, { "id": "NCT03117608_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03117608_exc_T9", "arg2_id": "NCT03117608_exc_T11", "normalized": [] }, { "id": "NCT03117608_exc_R6", "type": "Subsumes", "arg1_id": "NCT03117608_exc_T16", "arg2_id": "NCT03117608_exc_T17", "normalized": [] }, { "id": "NCT03117608_exc_R9", "type": "Has_value", "arg1_id": "NCT03117608_exc_T22", "arg2_id": "NCT03117608_exc_T23", "normalized": [] }, { "id": "NCT03117608_exc_R10", "type": "Has_value", "arg1_id": "NCT03117608_exc_T21", "arg2_id": "NCT03117608_exc_T23", "normalized": [] }, { "id": "NCT03117608_exc_R11", "type": "Has_value", "arg1_id": "NCT03117608_exc_T24", "arg2_id": "NCT03117608_exc_T25", "normalized": [] }, { "id": "NCT03117608_exc_R13", "type": "Has_index", "arg1_id": "NCT03117608_exc_T27", "arg2_id": "NCT03117608_exc_T28", "normalized": [] }, { "id": "NCT03117608_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03117608_exc_T26", "arg2_id": "NCT03117608_exc_T27", "normalized": [] } ]

[ { "id": "NCT03117608_inc_text", "type": "inclusion", "text": [ "Patients provided written informed consent;\nPatients aged between 18 and 75 years;\nKnee symptomatic OA (Kellgren-Lawrence grade 1-4)\nFailure of conservative treatment for at least 3 months;\nPatients agreed to actively participate in the rehabilitation protocol and follow-up program;\nMale or female patients;\nWomen of childbearing age had to use a proven method to prevent pregnancy, before the surgical treatment.\n" ], "offsets": [ [ 0, 415 ] ] } ]

[ { "id": "NCT03117608_inc_T1", "type": "Observation", "text": [ "provided written informed consent" ], "offsets": [ [ 9, 42 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T2", "type": "Person", "text": [ "aged" ], "offsets": [ [ 53, 57 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T3", "type": "Value", "text": [ "between 18 and 75 years" ], "offsets": [ [ 58, 81 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T4", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 88, 99 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T5", "type": "Condition", "text": [ " ", "ee s" ], "offsets": [ [ 102, 103 ], [ 85, 89 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T6", "type": "Measurement", "text": [ "Kellgren-Lawrence grade" ], "offsets": [ [ 104, 127 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T7", "type": "Value", "text": [ "1-4" ], "offsets": [ [ 128, 131 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T8", "type": "Scope", "text": [ "Kellgren-Lawrence grade 1-4" ], "offsets": [ [ 104, 131 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T9", "type": "Observation", "text": [ "Failure" ], "offsets": [ [ 133, 140 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T10", "type": "Procedure", "text": [ "conservative treatment" ], "offsets": [ [ 144, 166 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T11", "type": "Temporal", "text": [ "for at least 3 months" ], "offsets": [ [ 167, 188 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T12", "type": "Observation", "text": [ "agreed to actively participate in the rehabilitation protocol" ], "offsets": [ [ 199, 260 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T13", "type": "Observation", "text": [ "ed to actively participate in the reh", "ow-up program;\nMa" ], "offsets": [ [ 203, 240 ], [ 269, 286 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T14", "type": "Person", "text": [ "Male" ], "offsets": [ [ 284, 288 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T15", "type": "Person", "text": [ "female" ], "offsets": [ [ 292, 298 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T16", "type": "Observation", "text": [ "childbearing age" ], "offsets": [ [ 318, 334 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T17", "type": "Person", "text": [ "Women" ], "offsets": [ [ 309, 314 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T18", "type": "Observation", "text": [ "method to prevent pregnancy" ], "offsets": [ [ 355, 382 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T19", "type": "Temporal", "text": [ "before the surgical treatment" ], "offsets": [ [ 384, 413 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T20", "type": "Reference_point", "text": [ "the surgical treatment" ], "offsets": [ [ 391, 413 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T21", "type": "Procedure", "text": [ "surgical treatment" ], "offsets": [ [ 395, 413 ] ], "normalized": [] }, { "id": "NCT03117608_inc_T22", "type": "Scope", "text": [ "Women of childbearing age" ], "offsets": [ [ 309, 334 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03117608_inc_R1", "type": "Has_value", "arg1_id": "NCT03117608_inc_T2", "arg2_id": "NCT03117608_inc_T3", "normalized": [] }, { "id": "NCT03117608_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03117608_inc_T5", "arg2_id": "NCT03117608_inc_T4", "normalized": [] }, { "id": "NCT03117608_inc_R3", "type": "Has_value", "arg1_id": "NCT03117608_inc_T6", "arg2_id": "NCT03117608_inc_T7", "normalized": [] }, { "id": "NCT03117608_inc_R4", "type": "Subsumes", "arg1_id": "NCT03117608_inc_T4", "arg2_id": "NCT03117608_inc_T8", "normalized": [] }, { "id": "NCT03117608_inc_R6", "type": "Has_temporal", "arg1_id": "NCT03117608_inc_T9", "arg2_id": "NCT03117608_inc_T11", "normalized": [] }, { "id": "NCT03117608_inc_R7", "type": "Has_index", "arg1_id": "NCT03117608_inc_T19", "arg2_id": "NCT03117608_inc_T20", "normalized": [] }, { "id": "NCT03117608_inc_R8", "type": "AND", "arg1_id": "NCT03117608_inc_T20", "arg2_id": "NCT03117608_inc_T21", "normalized": [] }, { "id": "NCT03117608_inc_R9", "type": "Has_temporal", "arg1_id": "NCT03117608_inc_T18", "arg2_id": "NCT03117608_inc_T19", "normalized": [] } ]

[ { "id": "NCT03118232_exc_text", "type": "exclusion", "text": [ "Nursing homes will not be eligible to participate if they meet the following criteria:\nFacilities routinely using decolonization\nDedicated psychiatric nursing homes\nFacilities with a resident population with >=20% combative patients\nPediatric facilities\n" ], "offsets": [ [ 0, 254 ] ] } ]

[ { "id": "NCT03118232_exc_T2", "type": "Visit", "text": [ "Nursing homes" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT03118232_exc_T3", "type": "Multiplier", "text": [ "routinely" ], "offsets": [ [ 98, 107 ] ], "normalized": [] }, { "id": "NCT03118232_exc_T4", "type": "Procedure", "text": [ "decolonization" ], "offsets": [ [ 114, 128 ] ], "normalized": [] }, { "id": "NCT03118232_exc_T5", "type": "Visit", "text": [ "psychiatric nursing homes" ], "offsets": [ [ 139, 164 ] ], "normalized": [] }, { "id": "NCT03118232_exc_T6", "type": "Measurement", "text": [ "resident population" ], "offsets": [ [ 183, 202 ] ], "normalized": [] }, { "id": "NCT03118232_exc_T7", "type": "Value", "text": [ ">=20%" ], "offsets": [ [ 208, 213 ] ], "normalized": [] }, { "id": "NCT03118232_exc_T8", "type": "Observation", "text": [ "combative patients" ], "offsets": [ [ 214, 232 ] ], "normalized": [] }, { "id": "NCT03118232_exc_T9", "type": "Visit", "text": [ "Pediatric facilities" ], "offsets": [ [ 233, 253 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03118232_exc_R1", "type": "Has_multiplier", "arg1_id": "NCT03118232_exc_T4", "arg2_id": "NCT03118232_exc_T3", "normalized": [] }, { "id": "NCT03118232_exc_R2", "type": "AND", "arg1_id": "NCT03118232_exc_T8", "arg2_id": "NCT03118232_exc_T6", "normalized": [] }, { "id": "NCT03118232_exc_R3", "type": "Has_value", "arg1_id": "NCT03118232_exc_T6", "arg2_id": "NCT03118232_exc_T7", "normalized": [] } ]

[ { "id": "NCT03118232_inc_text", "type": "inclusion", "text": [ "Nursing homes will be eligible to participate if they meet the following criteria:\nLicensed nursing home in Orange County or Southern Los Angeles County serving adults\nMinimal use of chlorhexidine bathing*\nMinimal use of nasal decolonization* *Minimal use defined as <15% of residents receiving at least one chlorhexidine bath or nasal decolonization treatment during their nursing home stay.\n" ], "offsets": [ [ 0, 393 ] ] } ]

[ { "id": "NCT03118232_inc_T1", "type": "Visit", "text": [ "Nursing homes" ], "offsets": [ [ 0, 13 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T2", "type": "Visit", "text": [ "Licensed nursing home" ], "offsets": [ [ 83, 104 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T3", "type": "Visit", "text": [ "Orange County" ], "offsets": [ [ 108, 121 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T4", "type": "Visit", "text": [ "Southern Los Angeles County" ], "offsets": [ [ 125, 152 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T5", "type": "Qualifier", "text": [ "serving adults" ], "offsets": [ [ 153, 167 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T6", "type": "Scope", "text": [ "Licensed nursing home in Orange County or Southern Los Angeles County" ], "offsets": [ [ 83, 152 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T7", "type": "Procedure", "text": [ "chlorhexidine bathing" ], "offsets": [ [ 183, 204 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T8", "type": "Drug", "text": [ "chlorhexidine" ], "offsets": [ [ 183, 196 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T9", "type": "Multiplier", "text": [ "Minimal use" ], "offsets": [ [ 168, 179 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T10", "type": "Multiplier", "text": [ "Minimal use" ], "offsets": [ [ 206, 217 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T11", "type": "Procedure", "text": [ "nasal decolonization" ], "offsets": [ [ 221, 241 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T12", "type": "Multiplier", "text": [ "Minimal use" ], "offsets": [ [ 244, 255 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T13", "type": "Value", "text": [ "<15%" ], "offsets": [ [ 267, 271 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T14", "type": "Measurement", "text": [ "residents receiving at least one chlorhexidine bath" ], "offsets": [ [ 275, 326 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T15", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 295, 307 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T16", "type": "Procedure", "text": [ "chlorhexidine bath" ], "offsets": [ [ 308, 326 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T17", "type": "Drug", "text": [ "chlorhexidine" ], "offsets": [ [ 308, 321 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T18", "type": "Scope", "text": [ "<15% of residents receiving at least one chlorhexidine bath" ], "offsets": [ [ 267, 326 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T19", "type": "Procedure", "text": [ "nasal decolonization treatment" ], "offsets": [ [ 330, 360 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T20", "type": "Temporal", "text": [ "during their nursing home stay" ], "offsets": [ [ 361, 391 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T21", "type": "Scope", "text": [ "nasal decolonization treatment during their nursing home stay" ], "offsets": [ [ 330, 391 ] ], "normalized": [] }, { "id": "NCT03118232_inc_T22", "type": "Scope", "text": [ "<15% of residents receiving at least one chlorhexidine bath or nasal decolonization treatment during their nursing home stay" ], "offsets": [ [ 267, 391 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03118232_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03118232_inc_T6", "arg2_id": "NCT03118232_inc_T5", "normalized": [] }, { "id": "NCT03118232_inc_R3", "type": "Has_multiplier", "arg1_id": "NCT03118232_inc_T7", "arg2_id": "NCT03118232_inc_T9", "normalized": [] }, { "id": "NCT03118232_inc_R4", "type": "Has_multiplier", "arg1_id": "NCT03118232_inc_T11", "arg2_id": "NCT03118232_inc_T10", "normalized": [] }, { "id": "NCT03118232_inc_R6", "type": "Has_multiplier", "arg1_id": "NCT03118232_inc_T16", "arg2_id": "NCT03118232_inc_T15", "normalized": [] }, { "id": "NCT03118232_inc_R8", "type": "Has_value", "arg1_id": "NCT03118232_inc_T14", "arg2_id": "NCT03118232_inc_T13", "normalized": [] }, { "id": "NCT03118232_inc_R9", "type": "Has_multiplier", "arg1_id": "NCT03118232_inc_T10", "arg2_id": "NCT03118232_inc_T12", "normalized": [] }, { "id": "NCT03118232_inc_R10", "type": "Has_temporal", "arg1_id": "NCT03118232_inc_T19", "arg2_id": "NCT03118232_inc_T20", "normalized": [] }, { "id": "NCT03118232_inc_R11", "type": "Subsumes", "arg1_id": "NCT03118232_inc_T12", "arg2_id": "NCT03118232_inc_T22", "normalized": [] } ]

[ { "id": "NCT03119766_exc_text", "type": "exclusion", "text": [ "Organic diseases of the digestive system (gastro-oesophageal reflux disease (GERD), ulcer, chronic pancreatitis, cholelithiasis, fatty liver disease, hepatitis, cirrhosis of liver, etc.) .\nDiagnosis of other functional diseases of the digestive system, such as dyskinesia of cystic duct or gallbladder, irritable bowel syndrome, etc.\nDiscontinuation of proton pump inhibitors, propulsives, antispasmodics, antacids, or bismuth preparations less than 7 days prior to randomization.\nH. Pylori eradication within 2 months before study entry.\nIntestinal infection within 2 months before study entry.\nKnown history of/suspected malignant neoplasm of various sites.\nPrior diagnosis of a class IV cardiovascular disease (according to the New York Heart Association, 1964), hypothyroidism, diabetes mellitus, chronic kidney disease (С3-5), or disease of liver with portal hypertension and/or severe decompensation (Child-Pugh score > 6).\nOther severe coexisting morbidity which, in the investigator's opinion, can prevent the patient from participating in the study.\nAllergy/intolerance to any of the components of medications used in the treatment.\nPregnancy, breast-feeding.\nPatients who, from investigator's point of view, will fail to comply with the observation requirements of the trial or with the dosing regimen of the investigational drugs.\nPlanned hospitalization during the study period, for any diagnostic or treatment procedures.\nDrug addiction, alcohol use in the amount over 2 units of alcohol a day, mental diseases.\nIntake of medicines listed in the section 'Prohibited concomitant treatment' for 1 month prior to the enrollment in the trial.\nParticipation in other clinical trials within 3 months to the enrollment in this study.\nPatient is related to the research staff of the clinical investigative site who are directly involved in the trial or is the immediate family member of the investigator. The immediate family members include husband/wife, parents, children or brothers (or sisters), regardless of whether they are natural or adopted.\nPatient works for OOO \"NPF \"MATERIA MEDICA HOLDING\" (i.e., is the company's employee, temporary contract worker or appointed official responsible for carrying out the research or their immediate family).\n" ], "offsets": [ [ 0, 2260 ] ] } ]

[ { "id": "NCT03119766_exc_T1", "type": "Condition", "text": [ "Organic diseases" ], "offsets": [ [ 0, 16 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T2", "type": "Qualifier", "text": [ "digestive system" ], "offsets": [ [ 24, 40 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T3", "type": "Condition", "text": [ "gastro-oesophageal reflux disease (GERD)" ], "offsets": [ [ 42, 82 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T4", "type": "Condition", "text": [ "ulcer" ], "offsets": [ [ 84, 89 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T5", "type": "Condition", "text": [ "chronic pancreatitis" ], "offsets": [ [ 91, 111 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T6", "type": "Condition", "text": [ "cholelithiasis" ], "offsets": [ [ 113, 127 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T7", "type": "Condition", "text": [ "fatty liver disease" ], "offsets": [ [ 129, 148 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T8", "type": "Condition", "text": [ "hepatitis" ], "offsets": [ [ 150, 159 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T9", "type": "Condition", "text": [ "cirrhosis of liver" ], "offsets": [ [ 161, 179 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T10", "type": "Scope", "text": [ "gastro-oesophageal reflux disease (GERD), ulcer, chronic pancreatitis, cholelithiasis, fatty liver disease, hepatitis, cirrhosis of liver" ], "offsets": [ [ 42, 179 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T11", "type": "Scope", "text": [ "Organic diseases of the digestive system" ], "offsets": [ [ 0, 40 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T12", "type": "Condition", "text": [ "functional diseases" ], "offsets": [ [ 208, 227 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T13", "type": "Qualifier", "text": [ "digestive system" ], "offsets": [ [ 235, 251 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T14", "type": "Scope", "text": [ "functional diseases of the digestive system" ], "offsets": [ [ 208, 251 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T15", "type": "Condition", "text": [ "dyskinesia of cystic duct" ], "offsets": [ [ 261, 286 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T16", "type": "Condition", "text": [ "yskinesia of", "allbladder," ], "offsets": [ [ 262, 274 ], [ 291, 302 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T17", "type": "Condition", "text": [ "irritable bowel syndrome" ], "offsets": [ [ 303, 327 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T18", "type": "Scope", "text": [ "dyskinesia of cystic duct or gallbladder, irritable bowel syndrome" ], "offsets": [ [ 261, 327 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T19", "type": "Drug", "text": [ "proton pump inhibitors" ], "offsets": [ [ 353, 375 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T20", "type": "Drug", "text": [ "propulsives" ], "offsets": [ [ 377, 388 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T21", "type": "Drug", "text": [ "antispasmodics" ], "offsets": [ [ 390, 404 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T22", "type": "Drug", "text": [ "antacids" ], "offsets": [ [ 406, 414 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T23", "type": "Drug", "text": [ "bismuth preparations" ], "offsets": [ [ 419, 439 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T24", "type": "Observation", "text": [ "Discontinuation" ], "offsets": [ [ 334, 349 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T25", "type": "Temporal", "text": [ "less than 7 days prior to randomization" ], "offsets": [ [ 440, 479 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T26", "type": "Scope", "text": [ "proton pump inhibitors, propulsives, antispasmodics, antacids, or bismuth preparations" ], "offsets": [ [ 353, 439 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T27", "type": "Procedure", "text": [ "H. Pylori eradication" ], "offsets": [ [ 481, 502 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T28", "type": "Temporal", "text": [ "within 2 months before study entry" ], "offsets": [ [ 503, 537 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T29", "type": "Reference_point", "text": [ "study entry" ], "offsets": [ [ 526, 537 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T30", "type": "Reference_point", "text": [ "randomization" ], "offsets": [ [ 466, 479 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T31", "type": "Condition", "text": [ "Intestinal infection" ], "offsets": [ [ 539, 559 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T32", "type": "Temporal", "text": [ "within 2 months before study entry" ], "offsets": [ [ 560, 594 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T33", "type": "Reference_point", "text": [ "study entry" ], "offsets": [ [ 583, 594 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T34", "type": "Observation", "text": [ "history of" ], "offsets": [ [ 602, 612 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T35", "type": "Mood", "text": [ "suspected" ], "offsets": [ [ 613, 622 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T36", "type": "Condition", "text": [ "malignant neoplasm" ], "offsets": [ [ 623, 641 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T37", "type": "Qualifier", "text": [ "various sites" ], "offsets": [ [ 645, 658 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T38", "type": "Scope", "text": [ "history of/suspected" ], "offsets": [ [ 602, 622 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T39", "type": "Condition", "text": [ "cardiovascular disease" ], "offsets": [ [ 690, 712 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T40", "type": "Measurement", "text": [ "New York Heart Association" ], "offsets": [ [ 731, 757 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T41", "type": "Value", "text": [ "class IV" ], "offsets": [ [ 681, 689 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T42", "type": "Condition", "text": [ "hypothyroidism" ], "offsets": [ [ 766, 780 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T43", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 782, 799 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T44", "type": "Condition", "text": [ "chronic kidney disease" ], "offsets": [ [ 801, 823 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T45", "type": "Measurement", "text": [ "С" ], "offsets": [ [ 825, 826 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T46", "type": "Value", "text": [ "3-5" ], "offsets": [ [ 826, 829 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T47", "type": "Condition", "text": [ "disease of liver" ], "offsets": [ [ 835, 851 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T48", "type": "Condition", "text": [ "portal hypertension" ], "offsets": [ [ 857, 876 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T49", "type": "Condition", "text": [ "severe decompensation" ], "offsets": [ [ 884, 905 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T50", "type": "Scope", "text": [ "disease of liver with portal hypertension" ], "offsets": [ [ 835, 876 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T51", "type": "Measurement", "text": [ "Child-Pugh score" ], "offsets": [ [ 907, 923 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T52", "type": "Value", "text": [ "> 6" ], "offsets": [ [ 924, 927 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T53", "type": "Scope", "text": [ "Child-Pugh score > 6" ], "offsets": [ [ 907, 927 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T54", "type": "Temporal", "text": [ "coexisting" ], "offsets": [ [ 943, 953 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T55", "type": "Condition", "text": [ "morbidity" ], "offsets": [ [ 954, 963 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T57", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 1059, 1066 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T58", "type": "Condition", "text": [ "intolerance" ], "offsets": [ [ 1067, 1078 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T59", "type": "Drug", "text": [ "components of medications used in the treatment" ], "offsets": [ [ 1093, 1140 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T60", "type": "Scope", "text": [ "Allergy/intolerance" ], "offsets": [ [ 1059, 1078 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T61", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 1142, 1151 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T62", "type": "Observation", "text": [ "breast-feeding" ], "offsets": [ [ 1153, 1167 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T64", "type": "Mood", "text": [ "Planned" ], "offsets": [ [ 1342, 1349 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T65", "type": "Procedure", "text": [ "hospitalization" ], "offsets": [ [ 1350, 1365 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T66", "type": "Temporal", "text": [ "during the study period" ], "offsets": [ [ 1366, 1389 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T67", "type": "Procedure", "text": [ "treatment procedures" ], "offsets": [ [ 1413, 1433 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T68", "type": "Procedure", "text": [ "or treatme", "\nDrug add" ], "offsets": [ [ 1410, 1420 ], [ 1434, 1443 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T69", "type": "Scope", "text": [ "diagnostic or treatment procedures" ], "offsets": [ [ 1399, 1433 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T70", "type": "Condition", "text": [ "Drug addiction" ], "offsets": [ [ 1435, 1449 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T71", "type": "Measurement", "text": [ "alcohol use" ], "offsets": [ [ 1451, 1462 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T72", "type": "Value", "text": [ "over 2 units of alcohol a day" ], "offsets": [ [ 1477, 1506 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T73", "type": "Condition", "text": [ "mental diseases" ], "offsets": [ [ 1508, 1523 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T74", "type": "Drug", "text": [ "medicines" ], "offsets": [ [ 1535, 1544 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T75", "type": "Qualifier", "text": [ "listed in the section 'Prohibited concomitant treatment'" ], "offsets": [ [ 1545, 1601 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T76", "type": "Temporal", "text": [ "1 month prior to the enrollment in the trial" ], "offsets": [ [ 1606, 1650 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T77", "type": "Reference_point", "text": [ "the enrollment in the trial" ], "offsets": [ [ 1623, 1650 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T80", "type": "Person", "text": [ "works for OOO \"NPF \"MATERIA MEDICA HOLDING\"" ], "offsets": [ [ 2064, 2107 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T81", "type": "Person", "text": [ "company's employee" ], "offsets": [ [ 2122, 2140 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T82", "type": "Person", "text": [ "temporary contract worker" ], "offsets": [ [ 2142, 2167 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T83", "type": "Person", "text": [ "appointed official" ], "offsets": [ [ 2171, 2189 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T84", "type": "Observation", "text": [ "responsible for carrying out the research or their immediate family" ], "offsets": [ [ 2190, 2257 ] ], "normalized": [] }, { "id": "NCT03119766_exc_T85", "type": "Scope", "text": [ "company's employee, temporary contract worker or appointed official responsible for carrying out the research or their immediate family" ], "offsets": [ [ 2122, 2257 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03119766_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03119766_exc_T1", "arg2_id": "NCT03119766_exc_T2", "normalized": [] }, { "id": "NCT03119766_exc_R2", "type": "Subsumes", "arg1_id": "NCT03119766_exc_T11", "arg2_id": "NCT03119766_exc_T10", "normalized": [] }, { "id": "NCT03119766_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03119766_exc_T12", "arg2_id": "NCT03119766_exc_T13", "normalized": [] }, { "id": "NCT03119766_exc_R4", "type": "Subsumes", "arg1_id": "NCT03119766_exc_T14", "arg2_id": "NCT03119766_exc_T18", "normalized": [] }, { "id": "NCT03119766_exc_R5", "type": "Has_scope", "arg1_id": "NCT03119766_exc_T24", "arg2_id": "NCT03119766_exc_T26", "normalized": [] }, { "id": "NCT03119766_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03119766_exc_T24", "arg2_id": "NCT03119766_exc_T25", "normalized": [] }, { "id": "NCT03119766_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03119766_exc_T27", "arg2_id": "NCT03119766_exc_T28", "normalized": [] }, { "id": "NCT03119766_exc_R8", "type": "Has_index", "arg1_id": "NCT03119766_exc_T28", "arg2_id": "NCT03119766_exc_T29", "normalized": [] }, { "id": "NCT03119766_exc_R9", "type": "Has_index", "arg1_id": "NCT03119766_exc_T25", "arg2_id": "NCT03119766_exc_T30", "normalized": [] }, { "id": "NCT03119766_exc_R10", "type": "Has_index", "arg1_id": "NCT03119766_exc_T32", "arg2_id": "NCT03119766_exc_T33", "normalized": [] }, { "id": "NCT03119766_exc_R11", "type": "Has_temporal", "arg1_id": "NCT03119766_exc_T31", "arg2_id": "NCT03119766_exc_T32", "normalized": [] }, { "id": "NCT03119766_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT03119766_exc_T36", "arg2_id": "NCT03119766_exc_T37", "normalized": [] }, { "id": "NCT03119766_exc_R13", "type": "Has_scope", "arg1_id": "NCT03119766_exc_T36", "arg2_id": "NCT03119766_exc_T38", "normalized": [] }, { "id": "NCT03119766_exc_R14", "type": "Has_value", "arg1_id": "NCT03119766_exc_T40", "arg2_id": "NCT03119766_exc_T41", "normalized": [] }, { "id": "NCT03119766_exc_R15", "type": "AND", "arg1_id": "NCT03119766_exc_T39", "arg2_id": "NCT03119766_exc_T40", "normalized": [] }, { "id": "NCT03119766_exc_R16", "type": "Has_value", "arg1_id": "NCT03119766_exc_T45", "arg2_id": "NCT03119766_exc_T46", "normalized": [] }, { "id": "NCT03119766_exc_R17", "type": "AND", "arg1_id": "NCT03119766_exc_T44", "arg2_id": "NCT03119766_exc_T45", "normalized": [] }, { "id": "NCT03119766_exc_R18", "type": "Has_value", "arg1_id": "NCT03119766_exc_T51", "arg2_id": "NCT03119766_exc_T52", "normalized": [] }, { "id": "NCT03119766_exc_R19", "type": "Has_scope", "arg1_id": "NCT03119766_exc_T49", "arg2_id": "NCT03119766_exc_T53", "normalized": [] }, { "id": "NCT03119766_exc_R20", "type": "Has_temporal", "arg1_id": "NCT03119766_exc_T55", "arg2_id": "NCT03119766_exc_T54", "normalized": [] }, { "id": "NCT03119766_exc_R22", "type": "AND", "arg1_id": "NCT03119766_exc_T60", "arg2_id": "NCT03119766_exc_T59", "normalized": [] }, { "id": "NCT03119766_exc_R23", "type": "Has_temporal", "arg1_id": "NCT03119766_exc_T65", "arg2_id": "NCT03119766_exc_T66", "normalized": [] }, { "id": "NCT03119766_exc_R24", "type": "Has_mood", "arg1_id": "NCT03119766_exc_T65", "arg2_id": "NCT03119766_exc_T64", "normalized": [] }, { "id": "NCT03119766_exc_R25", "type": "Has_scope", "arg1_id": "NCT03119766_exc_T65", "arg2_id": "NCT03119766_exc_T69", "normalized": [] }, { "id": "NCT03119766_exc_R26", "type": "Has_value", "arg1_id": "NCT03119766_exc_T71", "arg2_id": "NCT03119766_exc_T72", "normalized": [] }, { "id": "NCT03119766_exc_R27", "type": "Has_qualifier", "arg1_id": "NCT03119766_exc_T74", "arg2_id": "NCT03119766_exc_T75", "normalized": [] }, { "id": "NCT03119766_exc_R28", "type": "Has_index", "arg1_id": "NCT03119766_exc_T76", "arg2_id": "NCT03119766_exc_T77", "normalized": [] }, { "id": "NCT03119766_exc_R29", "type": "Has_temporal", "arg1_id": "NCT03119766_exc_T74", "arg2_id": "NCT03119766_exc_T76", "normalized": [] }, { "id": "NCT03119766_exc_R31", "type": "Subsumes", "arg1_id": "NCT03119766_exc_T80", "arg2_id": "NCT03119766_exc_T85", "normalized": [] } ]

[ { "id": "NCT03119766_inc_text", "type": "inclusion", "text": [ "Men and women aged 18-45 years.\nDiagnosis of functional dyspepsia, based on the Rome IV criteria (2016).\nGIS score of at least 6.\nNegative H. pylori test .\nAvailability of a signed patient information sheet (Informed Consent form) for participation in the clinical trial.\nPatients who agree to use an effective method of contraception throughout the clinical trial.\n" ], "offsets": [ [ 0, 366 ] ] } ]

[ { "id": "NCT03119766_inc_T1", "type": "Person", "text": [ "Men" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03119766_inc_T2", "type": "Person", "text": [ "women" ], "offsets": [ [ 8, 13 ] ], "normalized": [] }, { "id": "NCT03119766_inc_T3", "type": "Person", "text": [ "aged" ], "offsets": [ [ 14, 18 ] ], "normalized": [] }, { "id": "NCT03119766_inc_T4", "type": "Value", "text": [ "18-45 years" ], "offsets": [ [ 19, 30 ] ], "normalized": [] }, { "id": "NCT03119766_inc_T5", "type": "Condition", "text": [ "functional dyspepsia" ], "offsets": [ [ 45, 65 ] ], "normalized": [] }, { "id": "NCT03119766_inc_T6", "type": "Measurement", "text": [ "Rome IV criteria (2016)" ], "offsets": [ [ 80, 103 ] ], "normalized": [] }, { "id": "NCT03119766_inc_T7", "type": "Measurement", "text": [ "GIS score" ], "offsets": [ [ 105, 114 ] ], "normalized": [] }, { "id": "NCT03119766_inc_T8", "type": "Value", "text": [ "at least 6" ], "offsets": [ [ 118, 128 ] ], "normalized": [] }, { "id": "NCT03119766_inc_T9", "type": "Measurement", "text": [ "H. pylori test" ], "offsets": [ [ 139, 153 ] ], "normalized": [] }, { "id": "NCT03119766_inc_T10", "type": "Value", "text": [ "Negative" ], "offsets": [ [ 130, 138 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03119766_inc_R1", "type": "Has_value", "arg1_id": "NCT03119766_inc_T3", "arg2_id": "NCT03119766_inc_T4", "normalized": [] }, { "id": "NCT03119766_inc_R2", "type": "AND", "arg1_id": "NCT03119766_inc_T6", "arg2_id": "NCT03119766_inc_T5", "normalized": [] }, { "id": "NCT03119766_inc_R3", "type": "Has_value", "arg1_id": "NCT03119766_inc_T7", "arg2_id": "NCT03119766_inc_T8", "normalized": [] }, { "id": "NCT03119766_inc_R4", "type": "Has_value", "arg1_id": "NCT03119766_inc_T9", "arg2_id": "NCT03119766_inc_T10", "normalized": [] } ]

[ { "id": "NCT03120533_exc_text", "type": "exclusion", "text": [ "Healthy Volunteers \nTreprostinil contraindications: Known hypersensitivity to treprostinil or any of the excipients, Pulmonary arterial hypertension related to veno-occlusive disease, Congestive heart failure due to severe left ventricular dysfunction, Severe hepatic insufficiency (Child-Pugh stage C), Evolving gastrointestinal ulcer, intracranial hemorrhage, recent trauma or other clinical condition that may lead to bleeding, Congenital or acquired valvular abnormalities with cardiac repercussions, Severe ischemic heart disease or unstable angina; Myocardial infarction in the last six months; Decompensated cardiac insufficiency not medically controlled; Severe arrhythmias; Cerebrovascular lesions (such as transient ischemic attack, stroke) that occurred within the last three months. \nPersons referred to in Articles L1121-5 to L1121-8 of the French Public health Code: pregnant woman, parturient, nursing mother, person deprived of liberty by judicial or administrative decision, person subject to a legal protection measure, can not Be included in clinical trials. \nSubject in an exclusion period from another study, \nSubject who would receive more than 4500 euros of compensation due to his participation in other biomedical research in the 12 months preceding this study \nSystemic sclerosis patients: \nIloprost cure carried out in the previous month or planned in the following month. \nInitiation or change of dosage of bosentan, sildenafil or calcium channel blockers in the previous month or in the following month \nDigital Sympathectomy or botulinum toxin injection planned in the following month. \nClinically superinfected digital ulcers \nTreprostinil contraindications: Known hypersensitivity to treprostinil or any of the excipients, Pulmonary arterial hypertension related to veno-occlusive disease, Congestive heart failure due to severe left ventricular dysfunction, Severe hepatic insufficiency (Child-Pugh stage C), Evolving gastrointestinal ulcer, intracranial hemorrhage, recent trauma or other clinical condition that may lead to bleeding, Congenital or acquired valvular abnormalities with cardiac repercussions, Severe ischemic heart disease or unstable angina; Myocardial infarction in the last six months; Decompensated cardiac insufficiency not medically controlled; Severe arrhythmias; Cerebrovascular lesions (such as transient ischemic attack, stroke) that occurred within the last three months. \nPersons referred to in Articles L1121-5 to L1121-8 of the French Public health Code: pregnant woman, parturient, nursing mother, person deprived of liberty by judicial or administrative decision, person subject to a legal protection measure, can not Be included in clinical trials. \nSubject in an exclusion period from another study, \nSubject who would receive more than 4500 euros of compensation due to his participation in other biomedical research in the 12 months preceding this study \n \n" ], "offsets": [ [ 0, 2936 ] ] } ]

[ { "id": "NCT03120533_exc_T2", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 33, 50 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T3", "type": "Drug", "text": [ "Treprostinil" ], "offsets": [ [ 20, 32 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T4", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 58, 74 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T5", "type": "Drug", "text": [ "treprostinil" ], "offsets": [ [ 78, 90 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T6", "type": "Drug", "text": [ "any of the excipients" ], "offsets": [ [ 94, 115 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T7", "type": "Condition", "text": [ "Pulmonary arterial hypertension" ], "offsets": [ [ 117, 148 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T8", "type": "Condition", "text": [ "veno-occlusive disease" ], "offsets": [ [ 160, 182 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T9", "type": "Condition", "text": [ "Congestive heart failure" ], "offsets": [ [ 184, 208 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T10", "type": "Condition", "text": [ "left ventricular dysfunction" ], "offsets": [ [ 223, 251 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T11", "type": "Condition", "text": [ "hepatic insufficiency" ], "offsets": [ [ 260, 281 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T12", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 216, 222 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T13", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 253, 259 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T14", "type": "Measurement", "text": [ "Child-Pugh" ], "offsets": [ [ 283, 293 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T15", "type": "Value", "text": [ "stage C" ], "offsets": [ [ 294, 301 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T16", "type": "Condition", "text": [ "gastrointestinal ulcer" ], "offsets": [ [ 313, 335 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T17", "type": "Qualifier", "text": [ "Evolving" ], "offsets": [ [ 304, 312 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T18", "type": "Condition", "text": [ "intracranial hemorrhage" ], "offsets": [ [ 337, 360 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T19", "type": "Condition", "text": [ "trauma" ], "offsets": [ [ 369, 375 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T20", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 362, 368 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T21", "type": "Condition", "text": [ "clinical condition that may lead to bleeding" ], "offsets": [ [ 385, 429 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T23", "type": "Condition", "text": [ "Congenital", "valvular abnormalities" ], "offsets": [ [ 431, 441 ], [ 454, 476 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T24", "type": "Condition", "text": [ "acquired valvular abnormalities" ], "offsets": [ [ 445, 476 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T25", "type": "Qualifier", "text": [ "with cardiac repercussions" ], "offsets": [ [ 477, 503 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T26", "type": "Condition", "text": [ "ischemic heart disease" ], "offsets": [ [ 512, 534 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T27", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 505, 511 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T28", "type": "Condition", "text": [ "unstable angina" ], "offsets": [ [ 538, 553 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T29", "type": "Condition", "text": [ "Myocardial infarction" ], "offsets": [ [ 555, 576 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T30", "type": "Temporal", "text": [ "in the last six months" ], "offsets": [ [ 577, 599 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T31", "type": "Condition", "text": [ "Decompensated cardiac insufficiency" ], "offsets": [ [ 601, 636 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T32", "type": "Qualifier", "text": [ "not medically controlled" ], "offsets": [ [ 637, 661 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T33", "type": "Condition", "text": [ "arrhythmias" ], "offsets": [ [ 670, 681 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T34", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 663, 669 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T35", "type": "Condition", "text": [ "Cerebrovascular lesions" ], "offsets": [ [ 683, 706 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T36", "type": "Condition", "text": [ "transient ischemic attack" ], "offsets": [ [ 716, 741 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T37", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 743, 749 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T38", "type": "Scope", "text": [ "transient ischemic attack, stroke" ], "offsets": [ [ 716, 749 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T39", "type": "Temporal", "text": [ "within the last three months" ], "offsets": [ [ 765, 793 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T41", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 881, 889 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T42", "type": "Person", "text": [ "woman" ], "offsets": [ [ 890, 895 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T43", "type": "Condition", "text": [ "parturient" ], "offsets": [ [ 897, 907 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T44", "type": "Condition", "text": [ "nursing" ], "offsets": [ [ 909, 916 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T45", "type": "Observation", "text": [ "deprived of liberty" ], "offsets": [ [ 932, 951 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T46", "type": "Scope", "text": [ "pregnant woman, parturient, nursing mother, person deprived of liberty" ], "offsets": [ [ 881, 951 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T51", "type": "Condition", "text": [ "Systemic sclerosis" ], "offsets": [ [ 1287, 1305 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T52", "type": "Drug", "text": [ "Iloprost" ], "offsets": [ [ 1317, 1325 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T53", "type": "Temporal", "text": [ "in the previous month" ], "offsets": [ [ 1343, 1364 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T54", "type": "Temporal", "text": [ "in the following month" ], "offsets": [ [ 1376, 1398 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T55", "type": "Observation", "text": [ "planned" ], "offsets": [ [ 1368, 1375 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T56", "type": "Drug", "text": [ "Iloprost" ], "offsets": [ [ 1317, 1325 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T58", "type": "Drug", "text": [ "bosentan" ], "offsets": [ [ 1435, 1443 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T59", "type": "Drug", "text": [ "sildenafil" ], "offsets": [ [ 1445, 1455 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T60", "type": "Drug", "text": [ "calcium channel blockers" ], "offsets": [ [ 1459, 1483 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T61", "type": "Temporal", "text": [ "in the previous month" ], "offsets": [ [ 1484, 1505 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T62", "type": "Temporal", "text": [ "in the following month" ], "offsets": [ [ 1509, 1531 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T63", "type": "Scope", "text": [ "in the previous month or in the following month" ], "offsets": [ [ 1484, 1531 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T64", "type": "Scope", "text": [ "bosentan, sildenafil or calcium channel blockers" ], "offsets": [ [ 1435, 1483 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T65", "type": "Procedure", "text": [ "Digital Sympathectomy" ], "offsets": [ [ 1533, 1554 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T66", "type": "Procedure", "text": [ "botulinum toxin injection" ], "offsets": [ [ 1558, 1583 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T67", "type": "Observation", "text": [ "planned" ], "offsets": [ [ 1584, 1591 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T69", "type": "Temporal", "text": [ "in the following month" ], "offsets": [ [ 1592, 1614 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T70", "type": "Scope", "text": [ "Digital Sympathectomy or botulinum toxin injection" ], "offsets": [ [ 1533, 1583 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T71", "type": "Condition", "text": [ "digital ulcers" ], "offsets": [ [ 1642, 1656 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T72", "type": "Observation", "text": [ "superinfected" ], "offsets": [ [ 1628, 1641 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T73", "type": "Drug", "text": [ "Treprostinil" ], "offsets": [ [ 1658, 1670 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T74", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 1671, 1688 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T75", "type": "Condition", "text": [ "hypersensitivity" ], "offsets": [ [ 1696, 1712 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T76", "type": "Drug", "text": [ "treprostinil" ], "offsets": [ [ 1716, 1728 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T77", "type": "Drug", "text": [ "any of the excipients" ], "offsets": [ [ 1732, 1753 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T78", "type": "Scope", "text": [ "treprostinil or any of the excipients" ], "offsets": [ [ 1716, 1753 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T79", "type": "Condition", "text": [ "Pulmonary arterial hypertension" ], "offsets": [ [ 1755, 1786 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T80", "type": "Condition", "text": [ "veno-occlusive disease" ], "offsets": [ [ 1798, 1820 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T81", "type": "Condition", "text": [ "Congestive heart failure" ], "offsets": [ [ 1822, 1846 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T82", "type": "Condition", "text": [ "left ventricular dysfunction" ], "offsets": [ [ 1861, 1889 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T83", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 1854, 1860 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T84", "type": "Condition", "text": [ "hepatic insufficiency" ], "offsets": [ [ 1898, 1919 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T85", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 1891, 1897 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T86", "type": "Measurement", "text": [ "Child-Pugh" ], "offsets": [ [ 1921, 1931 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T87", "type": "Value", "text": [ "stage C" ], "offsets": [ [ 1932, 1939 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T88", "type": "Condition", "text": [ "gastrointestinal ulcer" ], "offsets": [ [ 1951, 1973 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T89", "type": "Condition", "text": [ "intracranial hemorrhage" ], "offsets": [ [ 1975, 1998 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T90", "type": "Condition", "text": [ "trauma" ], "offsets": [ [ 2007, 2013 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T91", "type": "Temporal", "text": [ "recent" ], "offsets": [ [ 2000, 2006 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T92", "type": "Condition", "text": [ "clinical condition that may lead to bleeding" ], "offsets": [ [ 2023, 2067 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T94", "type": "Condition", "text": [ "Congenital", "valvular abnormalities" ], "offsets": [ [ 2069, 2079 ], [ 2092, 2114 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T95", "type": "Condition", "text": [ "acquired valvular abnormalities" ], "offsets": [ [ 2083, 2114 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T96", "type": "Qualifier", "text": [ "with cardiac repercussions" ], "offsets": [ [ 2115, 2141 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T97", "type": "Condition", "text": [ "ischemic heart disease" ], "offsets": [ [ 2150, 2172 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T98", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 2143, 2149 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T99", "type": "Condition", "text": [ "unstable angina" ], "offsets": [ [ 2176, 2191 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T100", "type": "Condition", "text": [ "Myocardial infarction" ], "offsets": [ [ 2193, 2214 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T101", "type": "Temporal", "text": [ "in the last six months" ], "offsets": [ [ 2215, 2237 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T102", "type": "Condition", "text": [ "Decompensated cardiac insufficiency" ], "offsets": [ [ 2239, 2274 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T103", "type": "Condition", "text": [ "arrhythmias" ], "offsets": [ [ 2308, 2319 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T104", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 2301, 2307 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T105", "type": "Condition", "text": [ "Cerebrovascular lesions" ], "offsets": [ [ 2321, 2344 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T106", "type": "Condition", "text": [ "transient ischemic attack" ], "offsets": [ [ 2354, 2379 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T107", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 2381, 2387 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T108", "type": "Temporal", "text": [ "within the last three months" ], "offsets": [ [ 2403, 2431 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T109", "type": "Scope", "text": [ "transient ischemic attack, stroke" ], "offsets": [ [ 2354, 2387 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T110", "type": "Scope", "text": [ "recent trauma" ], "offsets": [ [ 2000, 2013 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T112", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 2519, 2527 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T113", "type": "Person", "text": [ "woman" ], "offsets": [ [ 2528, 2533 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T114", "type": "Condition", "text": [ "parturient" ], "offsets": [ [ 2535, 2545 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T115", "type": "Condition", "text": [ "nursing" ], "offsets": [ [ 2547, 2554 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T116", "type": "Observation", "text": [ "deprived of liberty" ], "offsets": [ [ 2570, 2589 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T117", "type": "Observation", "text": [ "subject to a legal protection" ], "offsets": [ [ 2637, 2666 ] ], "normalized": [] }, { "id": "NCT03120533_exc_T118", "type": "Scope", "text": [ "pregnant woman, parturient, nursing mother, person deprived of liberty by judicial or administrative decision, person subject to a legal protection" ], "offsets": [ [ 2519, 2666 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03120533_exc_R1", "type": "AND", "arg1_id": "NCT03120533_exc_T2", "arg2_id": "NCT03120533_exc_T3", "normalized": [] }, { "id": "NCT03120533_exc_R2", "type": "AND", "arg1_id": "NCT03120533_exc_T4", "arg2_id": "NCT03120533_exc_T5", "normalized": [] }, { "id": "NCT03120533_exc_R3", "type": "Subsumes", "arg1_id": "NCT03120533_exc_T5", "arg2_id": "NCT03120533_exc_T6", "normalized": [] }, { "id": "NCT03120533_exc_R4", "type": "AND", "arg1_id": "NCT03120533_exc_T7", "arg2_id": "NCT03120533_exc_T8", "normalized": [] }, { "id": "NCT03120533_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T10", "arg2_id": "NCT03120533_exc_T12", "normalized": [] }, { "id": "NCT03120533_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T11", "arg2_id": "NCT03120533_exc_T13", "normalized": [] }, { "id": "NCT03120533_exc_R7", "type": "Has_value", "arg1_id": "NCT03120533_exc_T14", "arg2_id": "NCT03120533_exc_T15", "normalized": [] }, { "id": "NCT03120533_exc_R8", "type": "Subsumes", "arg1_id": "NCT03120533_exc_T13", "arg2_id": "NCT03120533_exc_T14", "normalized": [] }, { "id": "NCT03120533_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T16", "arg2_id": "NCT03120533_exc_T17", "normalized": [] }, { "id": "NCT03120533_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03120533_exc_T19", "arg2_id": "NCT03120533_exc_T20", "normalized": [] }, { "id": "NCT03120533_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T23", "arg2_id": "NCT03120533_exc_T25", "normalized": [] }, { "id": "NCT03120533_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T24", "arg2_id": "NCT03120533_exc_T25", "normalized": [] }, { "id": "NCT03120533_exc_R13", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T26", "arg2_id": "NCT03120533_exc_T27", "normalized": [] }, { "id": "NCT03120533_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03120533_exc_T29", "arg2_id": "NCT03120533_exc_T30", "normalized": [] }, { "id": "NCT03120533_exc_R15", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T31", "arg2_id": "NCT03120533_exc_T32", "normalized": [] }, { "id": "NCT03120533_exc_R16", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T33", "arg2_id": "NCT03120533_exc_T34", "normalized": [] }, { "id": "NCT03120533_exc_R17", "type": "AND", "arg1_id": "NCT03120533_exc_T31", "arg2_id": "NCT03120533_exc_T33", "normalized": [] }, { "id": "NCT03120533_exc_R18", "type": "Subsumes", "arg1_id": "NCT03120533_exc_T35", "arg2_id": "NCT03120533_exc_T38", "normalized": [] }, { "id": "NCT03120533_exc_R19", "type": "Has_temporal", "arg1_id": "NCT03120533_exc_T35", "arg2_id": "NCT03120533_exc_T39", "normalized": [] }, { "id": "NCT03120533_exc_R20", "type": "AND", "arg1_id": "NCT03120533_exc_T42", "arg2_id": "NCT03120533_exc_T41", "normalized": [] }, { "id": "NCT03120533_exc_R22", "type": "Has_temporal", "arg1_id": "NCT03120533_exc_T52", "arg2_id": "NCT03120533_exc_T53", "normalized": [] }, { "id": "NCT03120533_exc_R23", "type": "Has_mood", "arg1_id": "NCT03120533_exc_T56", "arg2_id": "NCT03120533_exc_T55", "normalized": [] }, { "id": "NCT03120533_exc_R24", "type": "Has_temporal", "arg1_id": "NCT03120533_exc_T56", "arg2_id": "NCT03120533_exc_T54", "normalized": [] }, { "id": "NCT03120533_exc_R25", "type": "Has_scope", "arg1_id": "NCT03120533_exc_T64", "arg2_id": "NCT03120533_exc_T63", "normalized": [] }, { "id": "NCT03120533_exc_R26", "type": "Has_mood", "arg1_id": "NCT03120533_exc_T70", "arg2_id": "NCT03120533_exc_T67", "normalized": [] }, { "id": "NCT03120533_exc_R27", "type": "Has_temporal", "arg1_id": "NCT03120533_exc_T70", "arg2_id": "NCT03120533_exc_T69", "normalized": [] }, { "id": "NCT03120533_exc_R29", "type": "AND", "arg1_id": "NCT03120533_exc_T74", "arg2_id": "NCT03120533_exc_T73", "normalized": [] }, { "id": "NCT03120533_exc_R30", "type": "Has_scope", "arg1_id": "NCT03120533_exc_T75", "arg2_id": "NCT03120533_exc_T78", "normalized": [] }, { "id": "NCT03120533_exc_R31", "type": "AND", "arg1_id": "NCT03120533_exc_T79", "arg2_id": "NCT03120533_exc_T80", "normalized": [] }, { "id": "NCT03120533_exc_R32", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T82", "arg2_id": "NCT03120533_exc_T83", "normalized": [] }, { "id": "NCT03120533_exc_R33", "type": "Has_value", "arg1_id": "NCT03120533_exc_T86", "arg2_id": "NCT03120533_exc_T87", "normalized": [] }, { "id": "NCT03120533_exc_R34", "type": "Subsumes", "arg1_id": "NCT03120533_exc_T85", "arg2_id": "NCT03120533_exc_T86", "normalized": [] }, { "id": "NCT03120533_exc_R35", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T84", "arg2_id": "NCT03120533_exc_T85", "normalized": [] }, { "id": "NCT03120533_exc_R36", "type": "Has_temporal", "arg1_id": "NCT03120533_exc_T90", "arg2_id": "NCT03120533_exc_T91", "normalized": [] }, { "id": "NCT03120533_exc_R37", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T94", "arg2_id": "NCT03120533_exc_T96", "normalized": [] }, { "id": "NCT03120533_exc_R38", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T95", "arg2_id": "NCT03120533_exc_T96", "normalized": [] }, { "id": "NCT03120533_exc_R39", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T97", "arg2_id": "NCT03120533_exc_T98", "normalized": [] }, { "id": "NCT03120533_exc_R40", "type": "Has_temporal", "arg1_id": "NCT03120533_exc_T100", "arg2_id": "NCT03120533_exc_T101", "normalized": [] }, { "id": "NCT03120533_exc_R41", "type": "Has_qualifier", "arg1_id": "NCT03120533_exc_T103", "arg2_id": "NCT03120533_exc_T104", "normalized": [] }, { "id": "NCT03120533_exc_R42", "type": "Subsumes", "arg1_id": "NCT03120533_exc_T105", "arg2_id": "NCT03120533_exc_T109", "normalized": [] }, { "id": "NCT03120533_exc_R43", "type": "Has_temporal", "arg1_id": "NCT03120533_exc_T105", "arg2_id": "NCT03120533_exc_T108", "normalized": [] }, { "id": "NCT03120533_exc_R44", "type": "Has_scope", "arg1_id": "NCT03120533_exc_T89", "arg2_id": "NCT03120533_exc_T110", "normalized": [] }, { "id": "NCT03120533_exc_R45", "type": "Subsumes", "arg1_id": "NCT03120533_exc_T110", "arg2_id": "NCT03120533_exc_T92", "normalized": [] }, { "id": "NCT03120533_exc_R46", "type": "AND", "arg1_id": "NCT03120533_exc_T113", "arg2_id": "NCT03120533_exc_T112", "normalized": [] } ]

[ { "id": "NCT03120533_inc_text", "type": "inclusion", "text": [ "Healthy Volunteers: \nAge of at least 18 years \nExistence of a contraceptive method for women of child-bearing age \nPerson affiliated to social security or beneficiary of such a scheme \nSigned consent form \nSystemic sclerosis patients: \nSystemic sclerosis meeting the EULAR criteria. \nPresence of at least 2 ischemic digital cutaneous ulcerations on two different fingers, with digital ulcers classified as \"active ulcers\" according to the North American working group definition: epithelial denudation is clearly Visible at one place and the bed of de-epithelialized ulcer can be seen; Ulcerations distal to the proximal interphalangeal joint, not associated with calcinosis or bony relief. \nUlcers whose major axis measured with the electronic caliper is ≥ 2 mm \nAge greater than or equal to 18 years \nExistence of a contraceptive method for women of reproductive age \nA person who is or is a beneficiary of social security \nInformed and signed consent signed by the patient or his / her legal representative. \n" ], "offsets": [ [ 0, 1012 ] ] } ]

[ { "id": "NCT03120533_inc_T2", "type": "Value", "text": [ "at least 18 years" ], "offsets": [ [ 28, 45 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T3", "type": "Person", "text": [ "Age" ], "offsets": [ [ 21, 24 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T4", "type": "Device", "text": [ "contraceptive method" ], "offsets": [ [ 62, 82 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T5", "type": "Person", "text": [ "women" ], "offsets": [ [ 87, 92 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T6", "type": "Value", "text": [ "child-bearing" ], "offsets": [ [ 96, 109 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T7", "type": "Person", "text": [ "age" ], "offsets": [ [ 110, 113 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T8", "type": "Scope", "text": [ "women of child-bearing age" ], "offsets": [ [ 87, 113 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T12", "type": "Condition", "text": [ "Systemic sclerosis" ], "offsets": [ [ 236, 254 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T13", "type": "Measurement", "text": [ "EULAR criteria" ], "offsets": [ [ 267, 281 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T14", "type": "Value", "text": [ "meeting" ], "offsets": [ [ 255, 262 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T15", "type": "Multiplier", "text": [ "at least 2", "on two different fingers" ], "offsets": [ [ 296, 306 ], [ 346, 370 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T16", "type": "Condition", "text": [ "ischemic digital cutaneous ulcerations" ], "offsets": [ [ 307, 345 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T17", "type": "Condition", "text": [ "digital ulcers" ], "offsets": [ [ 377, 391 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T18", "type": "Qualifier", "text": [ "active" ], "offsets": [ [ 407, 413 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T19", "type": "Measurement", "text": [ "North American working group definition" ], "offsets": [ [ 439, 478 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T20", "type": "Qualifier", "text": [ "epithelial denudation is clearly Visible at one place and the bed of de-epithelialized ulcer can be seen; Ulcerations distal to the proximal interphalangeal joint, not associated with calcinosis or bony relief" ], "offsets": [ [ 480, 689 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T21", "type": "Condition", "text": [ "Ulcers" ], "offsets": [ [ 692, 698 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T22", "type": "Measurement", "text": [ "major axis" ], "offsets": [ [ 705, 715 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T23", "type": "Value", "text": [ "≥ 2 mm" ], "offsets": [ [ 756, 762 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T24", "type": "Qualifier", "text": [ "measured with the electronic caliper" ], "offsets": [ [ 716, 752 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T25", "type": "Person", "text": [ "Age" ], "offsets": [ [ 764, 767 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T26", "type": "Value", "text": [ "greater than or equal to 18 years" ], "offsets": [ [ 768, 801 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T27", "type": "Device", "text": [ "contraceptive" ], "offsets": [ [ 818, 831 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T28", "type": "Person", "text": [ "women" ], "offsets": [ [ 843, 848 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T29", "type": "Value", "text": [ "reproductive" ], "offsets": [ [ 852, 864 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T30", "type": "Person", "text": [ "age" ], "offsets": [ [ 865, 868 ] ], "normalized": [] }, { "id": "NCT03120533_inc_T31", "type": "Scope", "text": [ "women of reproductive age" ], "offsets": [ [ 843, 868 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03120533_inc_R1", "type": "Has_value", "arg1_id": "NCT03120533_inc_T3", "arg2_id": "NCT03120533_inc_T2", "normalized": [] }, { "id": "NCT03120533_inc_R2", "type": "AND", "arg1_id": "NCT03120533_inc_T5", "arg2_id": "NCT03120533_inc_T7", "normalized": [] }, { "id": "NCT03120533_inc_R3", "type": "Has_value", "arg1_id": "NCT03120533_inc_T7", "arg2_id": "NCT03120533_inc_T6", "normalized": [] }, { "id": "NCT03120533_inc_R4", "type": "AND", "arg1_id": "NCT03120533_inc_T8", "arg2_id": "NCT03120533_inc_T4", "normalized": [] }, { "id": "NCT03120533_inc_R5", "type": "Has_value", "arg1_id": "NCT03120533_inc_T13", "arg2_id": "NCT03120533_inc_T14", "normalized": [] }, { "id": "NCT03120533_inc_R6", "type": "AND", "arg1_id": "NCT03120533_inc_T12", "arg2_id": "NCT03120533_inc_T13", "normalized": [] }, { "id": "NCT03120533_inc_R7", "type": "Has_multiplier", "arg1_id": "NCT03120533_inc_T16", "arg2_id": "NCT03120533_inc_T15", "normalized": [] }, { "id": "NCT03120533_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT03120533_inc_T17", "arg2_id": "NCT03120533_inc_T18", "normalized": [] }, { "id": "NCT03120533_inc_R9", "type": "Subsumes", "arg1_id": "NCT03120533_inc_T19", "arg2_id": "NCT03120533_inc_T20", "normalized": [] }, { "id": "NCT03120533_inc_R10", "type": "Subsumes", "arg1_id": "NCT03120533_inc_T18", "arg2_id": "NCT03120533_inc_T19", "normalized": [] }, { "id": "NCT03120533_inc_R11", "type": "AND", "arg1_id": "NCT03120533_inc_T16", "arg2_id": "NCT03120533_inc_T17", "normalized": [] }, { "id": "NCT03120533_inc_R12", "type": "Has_qualifier", "arg1_id": "NCT03120533_inc_T22", "arg2_id": "NCT03120533_inc_T24", "normalized": [] }, { "id": "NCT03120533_inc_R13", "type": "Has_value", "arg1_id": "NCT03120533_inc_T22", "arg2_id": "NCT03120533_inc_T23", "normalized": [] }, { "id": "NCT03120533_inc_R14", "type": "AND", "arg1_id": "NCT03120533_inc_T21", "arg2_id": "NCT03120533_inc_T22", "normalized": [] }, { "id": "NCT03120533_inc_R15", "type": "Has_value", "arg1_id": "NCT03120533_inc_T25", "arg2_id": "NCT03120533_inc_T26", "normalized": [] }, { "id": "NCT03120533_inc_R16", "type": "Has_value", "arg1_id": "NCT03120533_inc_T30", "arg2_id": "NCT03120533_inc_T29", "normalized": [] }, { "id": "NCT03120533_inc_R17", "type": "AND", "arg1_id": "NCT03120533_inc_T28", "arg2_id": "NCT03120533_inc_T30", "normalized": [] }, { "id": "NCT03120533_inc_R18", "type": "AND", "arg1_id": "NCT03120533_inc_T31", "arg2_id": "NCT03120533_inc_T27", "normalized": [] } ]

[ { "id": "NCT03120728_exc_text", "type": "exclusion", "text": [ "Currently pregnant or breastfeeding\nSevere pelvic organ prolapse or prolapse to any degree that may prevent retention of the vaginal ring after insertion\nUse of oral contraceptive pills, patches, implants or hormonal intrauterine contraception in the month prior to screening\nUse of depo medroxyprogesterone within 6 months of screening\nUse of medications that interact with contraceptive steroid hormones: anti-epileptic medications, rifampin, rifabutin, fosamprenavir, etc\nMedical condition with safety deemed to be category 3 or 4 when using a combined hormonal contraceptive, as determined by the Center for Disease Control Medical Eligibility Criteria: current or past history of breast cancer, severe decompensated cirrhosis, history of deep vein thrombosis or pulmonary embolus, diabetes with nephropathy/retinopathy/neuropathy or other vascular disease diagnosed more than 20 years ago, current symptomatic gallbladder disease, hypertension, ischemic heart disease, known thrombogenic mutations, hepatocellular adenoma, malignant hepatoma, multiple risk factors for atherosclerotic cardiovascular disease, multiple sclerosis with prolonged immobility, history of peripartum cardiomyopathy, cigarette smoking and =35yo, history of complicated solid organ transplant, history of stroke, history of superficial venous thrombosis not associated with catheter, systemic lupus erythematosus with positive antiphospholipid antibodies, valvular heart disease complicated by pulmonary hypertension or atrial fibrillation or bacterial endocarditis, and acute viral hepatitis\n" ], "offsets": [ [ 0, 1573 ] ] } ]

[ { "id": "NCT03120728_exc_T1", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 10, 18 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T2", "type": "Temporal", "text": [ "Currently" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T3", "type": "Observation", "text": [ "breastfeeding" ], "offsets": [ [ 22, 35 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T4", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 36, 42 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T5", "type": "Condition", "text": [ "pelvic organ prolapse" ], "offsets": [ [ 43, 64 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T6", "type": "Condition", "text": [ "prolapse" ], "offsets": [ [ 68, 76 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T8", "type": "Qualifier", "text": [ "may prevent retention of the vaginal ring after insertion" ], "offsets": [ [ 96, 153 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T9", "type": "Scope", "text": [ "pelvic organ prolapse or prolapse" ], "offsets": [ [ 43, 76 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T7", "type": "Drug", "text": [ "oral contraceptive pills" ], "offsets": [ [ 161, 185 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T10", "type": "Device", "text": [ "patches" ], "offsets": [ [ 187, 194 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T11", "type": "Device", "text": [ "implants" ], "offsets": [ [ 196, 204 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T12", "type": "Procedure", "text": [ "hormonal intrauterine contraception" ], "offsets": [ [ 208, 243 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T13", "type": "Temporal", "text": [ "in the month prior to screening" ], "offsets": [ [ 244, 275 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T14", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 266, 275 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T15", "type": "Scope", "text": [ "oral contraceptive pills, patches, implants or hormonal intrauterine contraception" ], "offsets": [ [ 161, 243 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T16", "type": "Drug", "text": [ "depo medroxyprogesterone" ], "offsets": [ [ 283, 307 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T17", "type": "Temporal", "text": [ "within 6 months of screening" ], "offsets": [ [ 308, 336 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T18", "type": "Drug", "text": [ "medications" ], "offsets": [ [ 344, 355 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T19", "type": "Observation", "text": [ "interact with" ], "offsets": [ [ 361, 374 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T20", "type": "Drug", "text": [ "contraceptive steroid hormones" ], "offsets": [ [ 375, 405 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T21", "type": "Drug", "text": [ "anti-epileptic medications" ], "offsets": [ [ 407, 433 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T22", "type": "Drug", "text": [ "rifampin" ], "offsets": [ [ 435, 443 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T23", "type": "Drug", "text": [ "rifabutin" ], "offsets": [ [ 445, 454 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T24", "type": "Drug", "text": [ "fosamprenavir" ], "offsets": [ [ 456, 469 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T25", "type": "Scope", "text": [ "anti-epileptic medications, rifampin, rifabutin, fosamprenavir" ], "offsets": [ [ 407, 469 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T26", "type": "Scope", "text": [ "medications that interact with contraceptive steroid hormones" ], "offsets": [ [ 344, 405 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T27", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 658, 665 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T28", "type": "Temporal", "text": [ "past" ], "offsets": [ [ 669, 673 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T29", "type": "Observation", "text": [ "history" ], "offsets": [ [ 674, 681 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T30", "type": "Condition", "text": [ "breast cancer" ], "offsets": [ [ 685, 698 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T31", "type": "Scope", "text": [ "current or past" ], "offsets": [ [ 658, 673 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T32", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 700, 706 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T33", "type": "Qualifier", "text": [ "decompensated" ], "offsets": [ [ 707, 720 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T34", "type": "Condition", "text": [ "cirrhosis" ], "offsets": [ [ 721, 730 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T35", "type": "Observation", "text": [ "history" ], "offsets": [ [ 732, 739 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T36", "type": "Condition", "text": [ "deep vein thrombosis" ], "offsets": [ [ 743, 763 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T37", "type": "Condition", "text": [ "pulmonary embolus" ], "offsets": [ [ 767, 784 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T38", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 786, 794 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T39", "type": "Condition", "text": [ "nephropathy" ], "offsets": [ [ 800, 811 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T40", "type": "Condition", "text": [ "retinopathy" ], "offsets": [ [ 812, 823 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T41", "type": "Condition", "text": [ "neuropathy" ], "offsets": [ [ 824, 834 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T42", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 838, 843 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T43", "type": "Condition", "text": [ "vascular disease" ], "offsets": [ [ 844, 860 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T44", "type": "Temporal", "text": [ "more than 20 years ago" ], "offsets": [ [ 871, 893 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T45", "type": "Scope", "text": [ "nephropathy/retinopathy/neuropathy or other vascular disease" ], "offsets": [ [ 800, 860 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T46", "type": "Temporal", "text": [ "current" ], "offsets": [ [ 895, 902 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T47", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 903, 914 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T48", "type": "Condition", "text": [ "gallbladder disease" ], "offsets": [ [ 915, 934 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T49", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 936, 948 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T50", "type": "Condition", "text": [ "ischemic heart disease" ], "offsets": [ [ 950, 972 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T51", "type": "Condition", "text": [ "thrombogenic mutations" ], "offsets": [ [ 980, 1002 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T52", "type": "Condition", "text": [ "hepatocellular adenoma" ], "offsets": [ [ 1004, 1026 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T53", "type": "Condition", "text": [ "malignant hepatoma" ], "offsets": [ [ 1028, 1046 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T54", "type": "Drug", "text": [ "combined hormonal contraceptive" ], "offsets": [ [ 547, 578 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T55", "type": "Multiplier", "text": [ "multiple" ], "offsets": [ [ 1048, 1056 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T56", "type": "Mood", "text": [ "risk factors" ], "offsets": [ [ 1057, 1069 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T57", "type": "Condition", "text": [ "atherosclerotic cardiovascular disease" ], "offsets": [ [ 1074, 1112 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T58", "type": "Condition", "text": [ "multiple sclerosis" ], "offsets": [ [ 1114, 1132 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T59", "type": "Condition", "text": [ "prolonged immobility" ], "offsets": [ [ 1138, 1158 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T60", "type": "Observation", "text": [ "history" ], "offsets": [ [ 1160, 1167 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T61", "type": "Condition", "text": [ "peripartum cardiomyopathy" ], "offsets": [ [ 1171, 1196 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T62", "type": "Observation", "text": [ "cigarette smoking" ], "offsets": [ [ 1198, 1215 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T63", "type": "Value", "text": [ "=35yo" ], "offsets": [ [ 1220, 1225 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T64", "type": "Person", "text": [ "yo" ], "offsets": [ [ 1223, 1225 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T65", "type": "Scope", "text": [ "cigarette smoking and =35yo" ], "offsets": [ [ 1198, 1225 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T66", "type": "Procedure", "text": [ "complicated solid organ transplant" ], "offsets": [ [ 1238, 1272 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T67", "type": "Observation", "text": [ "history" ], "offsets": [ [ 1227, 1234 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T68", "type": "Observation", "text": [ "history" ], "offsets": [ [ 1274, 1281 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T69", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 1285, 1291 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T70", "type": "Observation", "text": [ "history" ], "offsets": [ [ 1293, 1300 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T71", "type": "Condition", "text": [ "superficial venous thrombosis" ], "offsets": [ [ 1304, 1333 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T72", "type": "Qualifier", "text": [ "not associated" ], "offsets": [ [ 1334, 1348 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T73", "type": "Device", "text": [ "catheter" ], "offsets": [ [ 1354, 1362 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T74", "type": "Condition", "text": [ "systemic lupus erythematosus" ], "offsets": [ [ 1364, 1392 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T75", "type": "Value", "text": [ "positive" ], "offsets": [ [ 1398, 1406 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T76", "type": "Measurement", "text": [ "antiphospholipid antibodies" ], "offsets": [ [ 1407, 1434 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T77", "type": "Condition", "text": [ "valvular heart disease" ], "offsets": [ [ 1436, 1458 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T78", "type": "Condition", "text": [ "pulmonary hypertension" ], "offsets": [ [ 1474, 1496 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T79", "type": "Condition", "text": [ "atrial fibrillation" ], "offsets": [ [ 1500, 1519 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T80", "type": "Condition", "text": [ "bacterial endocarditis" ], "offsets": [ [ 1523, 1545 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T81", "type": "Condition", "text": [ "acute viral hepatitis" ], "offsets": [ [ 1551, 1572 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T82", "type": "Scope", "text": [ "valvular heart disease complicated by pulmonary hypertension or atrial fibrillation or bacterial endocarditis" ], "offsets": [ [ 1436, 1545 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T83", "type": "Scope", "text": [ "gallbladder disease, hypertension, ischemic heart disease" ], "offsets": [ [ 915, 972 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T84", "type": "Condition", "text": [ "Medical condition" ], "offsets": [ [ 475, 492 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T86", "type": "Value", "text": [ "3 or 4" ], "offsets": [ [ 527, 533 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T87", "type": "Measurement", "text": [ "Center for Disease Control Medical Eligibility Criteria" ], "offsets": [ [ 601, 656 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T85", "type": "Measurement", "text": [ "y deem", "ory 3 or" ], "offsets": [ [ 503, 509 ], [ 523, 531 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T88", "type": "Scope", "text": [ "current or past history of breast cancer, severe decompensated cirrhosis, history of deep vein thrombosis or pulmonary embolus, diabetes with nephropathy/retinopathy/neuropathy or other vascular disease diagnosed more than 20 years ago, current symptomatic gallbladder disease, hypertension, ischemic heart disease, known thrombogenic mutations, hepatocellular adenoma, malignant hepatoma, multiple risk factors for atherosclerotic cardiovascular disease, multiple sclerosis with prolonged immobility, history of peripartum cardiomyopathy, cigarette smoking and =35yo, history of complicated solid organ transplant, history of stroke, history of superficial venous thrombosis not associated with catheter, systemic lupus erythematosus with positive antiphospholipid antibodies, valvular heart disease complicated by pulmonary hypertension or atrial fibrillation or bacterial endocarditis, and acute viral hepatitis" ], "offsets": [ [ 658, 1572 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T89", "type": "Scope", "text": [ "Medical condition with safety deemed to be category 3 or 4 when using a combined hormonal contraceptive, as determined by the Center for Disease Control Medical Eligibility Criteria" ], "offsets": [ [ 475, 656 ] ], "normalized": [] }, { "id": "NCT03120728_exc_T90", "type": "Scope", "text": [ "pregnant or breastfeeding" ], "offsets": [ [ 10, 35 ] ], "normalized": [] } ]

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[ { "id": "NCT03120728_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03120728_exc_T9", "arg2_id": "NCT03120728_exc_T4", "normalized": [] }, { "id": "NCT03120728_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03120728_exc_T9", "arg2_id": "NCT03120728_exc_T8", "normalized": [] }, { "id": "NCT03120728_exc_R3", "type": "Has_index", "arg1_id": "NCT03120728_exc_T13", "arg2_id": "NCT03120728_exc_T14", "normalized": [] }, { "id": "NCT03120728_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03120728_exc_T15", "arg2_id": "NCT03120728_exc_T13", "normalized": [] }, { "id": "NCT03120728_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03120728_exc_T16", "arg2_id": "NCT03120728_exc_T17", "normalized": [] }, { "id": "NCT03120728_exc_R7", "type": "AND", "arg1_id": "NCT03120728_exc_T19", "arg2_id": "NCT03120728_exc_T20", "normalized": [] }, { "id": "NCT03120728_exc_R8", "type": "Subsumes", "arg1_id": "NCT03120728_exc_T26", "arg2_id": "NCT03120728_exc_T25", "normalized": [] }, { "id": "NCT03120728_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03120728_exc_T30", "arg2_id": "NCT03120728_exc_T29", "normalized": [] }, { "id": "NCT03120728_exc_R10", "type": "Has_scope", "arg1_id": "NCT03120728_exc_T29", "arg2_id": "NCT03120728_exc_T31", "normalized": [] }, { "id": "NCT03120728_exc_R11", "type": "Has_qualifier", "arg1_id": "NCT03120728_exc_T34", "arg2_id": "NCT03120728_exc_T33", "normalized": [] }, { "id": "NCT03120728_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT03120728_exc_T34", "arg2_id": "NCT03120728_exc_T32", "normalized": [] }, { "id": "NCT03120728_exc_R13", "type": "Has_temporal", "arg1_id": "NCT03120728_exc_T45", "arg2_id": "NCT03120728_exc_T44", "normalized": [] }, { "id": "NCT03120728_exc_R14", "type": "Has_scope", "arg1_id": "NCT03120728_exc_T38", "arg2_id": "NCT03120728_exc_T45", "normalized": [] }, { "id": "NCT03120728_exc_R15", "type": "Has_mood", "arg1_id": "NCT03120728_exc_T57", "arg2_id": "NCT03120728_exc_T56", "normalized": [] }, { "id": "NCT03120728_exc_R16", "type": "Has_multiplier", "arg1_id": "NCT03120728_exc_T56", "arg2_id": "NCT03120728_exc_T55", "normalized": [] }, { "id": "NCT03120728_exc_R17", "type": "AND", "arg1_id": "NCT03120728_exc_T58", "arg2_id": "NCT03120728_exc_T59", "normalized": [] }, { "id": "NCT03120728_exc_R18", "type": "Has_value", "arg1_id": "NCT03120728_exc_T64", "arg2_id": "NCT03120728_exc_T63", "normalized": [] }, { "id": "NCT03120728_exc_R19", "type": "Has_temporal", "arg1_id": "NCT03120728_exc_T61", "arg2_id": "NCT03120728_exc_T60", "normalized": [] }, { "id": "NCT03120728_exc_R20", "type": "Has_value", "arg1_id": "NCT03120728_exc_T76", "arg2_id": "NCT03120728_exc_T75", "normalized": [] }, { "id": "NCT03120728_exc_R21", "type": "AND", "arg1_id": "NCT03120728_exc_T74", "arg2_id": "NCT03120728_exc_T76", "normalized": [] }, { "id": "NCT03120728_exc_R22", "type": "Has_qualifier", "arg1_id": "NCT03120728_exc_T71", "arg2_id": "NCT03120728_exc_T72", "normalized": [] }, { "id": "NCT03120728_exc_R23", "type": "AND", "arg1_id": "NCT03120728_exc_T72", "arg2_id": "NCT03120728_exc_T73", "normalized": [] }, { "id": "NCT03120728_exc_R24", "type": "Has_temporal", "arg1_id": "NCT03120728_exc_T71", "arg2_id": "NCT03120728_exc_T70", "normalized": [] }, { "id": "NCT03120728_exc_R25", "type": "Has_temporal", "arg1_id": "NCT03120728_exc_T69", "arg2_id": "NCT03120728_exc_T68", "normalized": [] }, { "id": "NCT03120728_exc_R26", "type": "Has_temporal", "arg1_id": "NCT03120728_exc_T66", "arg2_id": "NCT03120728_exc_T67", "normalized": [] }, { "id": "NCT03120728_exc_R27", "type": "Has_qualifier", "arg1_id": "NCT03120728_exc_T83", "arg2_id": "NCT03120728_exc_T47", "normalized": [] }, { "id": "NCT03120728_exc_R28", "type": "Has_temporal", "arg1_id": "NCT03120728_exc_T83", "arg2_id": "NCT03120728_exc_T46", "normalized": [] }, { "id": "NCT03120728_exc_R29", "type": "Subsumes", "arg1_id": "NCT03120728_exc_T85", "arg2_id": "NCT03120728_exc_T87", "normalized": [] }, { "id": "NCT03120728_exc_R30", "type": "Has_value", "arg1_id": "NCT03120728_exc_T85", "arg2_id": "NCT03120728_exc_T86", "normalized": [] }, { "id": "NCT03120728_exc_R31", "type": "AND", "arg1_id": "NCT03120728_exc_T85", "arg2_id": "NCT03120728_exc_T54", "normalized": [] }, { "id": "NCT03120728_exc_R32", "type": "AND", "arg1_id": "NCT03120728_exc_T84", "arg2_id": "NCT03120728_exc_T85", "normalized": [] }, { "id": "NCT03120728_exc_R33", "type": "Subsumes", "arg1_id": "NCT03120728_exc_T89", "arg2_id": "NCT03120728_exc_T88", "normalized": [] }, { "id": "NCT03120728_exc_R34", "type": "Has_temporal", "arg1_id": "NCT03120728_exc_T90", "arg2_id": "NCT03120728_exc_T2", "normalized": [] } ]

[ { "id": "NCT03120728_inc_text", "type": "inclusion", "text": [ "Healthy, women ages 18 to 39yo with BMI <30\nRegular menstrual cycles with duration between 24-35 days\nCompletion of screening visit where ovulation will be assessed with blood draw for progesterone level (must be 5ng/mL or greater)\nNot seeking pregnancy during the study period\nUse of a non-hormonal form of contraception, such as: sterilization (tubal ligation, Essure), copper IUD (intrauterine device), barrier methods or abstinence\nMust speak English or Spanish\n" ], "offsets": [ [ 0, 466 ] ] } ]

[ { "id": "NCT03120728_inc_T1", "type": "Condition", "text": [ "Healthy" ], "offsets": [ [ 0, 7 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T2", "type": "Person", "text": [ "women" ], "offsets": [ [ 9, 14 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T3", "type": "Person", "text": [ "ages" ], "offsets": [ [ 15, 19 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T4", "type": "Value", "text": [ "18 to 39yo" ], "offsets": [ [ 20, 30 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T5", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 36, 39 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T6", "type": "Value", "text": [ "<30" ], "offsets": [ [ 40, 43 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T7", "type": "Condition", "text": [ "Regular menstrual cycles" ], "offsets": [ [ 44, 68 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T8", "type": "Value", "text": [ "between 24-35 days" ], "offsets": [ [ 83, 101 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T9", "type": "Measurement", "text": [ "duration" ], "offsets": [ [ 74, 82 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T11", "type": "Measurement", "text": [ "progesterone level" ], "offsets": [ [ 185, 203 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T10", "type": "Value", "text": [ "5ng/mL or greater" ], "offsets": [ [ 213, 230 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T13", "type": "Procedure", "text": [ "non-hormonal form of contraception" ], "offsets": [ [ 287, 321 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T14", "type": "Procedure", "text": [ "sterilization" ], "offsets": [ [ 332, 345 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T15", "type": "Procedure", "text": [ "tubal ligation" ], "offsets": [ [ 347, 361 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T16", "type": "Procedure", "text": [ "Essure" ], "offsets": [ [ 363, 369 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T17", "type": "Scope", "text": [ "tubal ligation, Essure" ], "offsets": [ [ 347, 369 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T18", "type": "Procedure", "text": [ "copper IUD" ], "offsets": [ [ 372, 382 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T19", "type": "Procedure", "text": [ "intrauterine device" ], "offsets": [ [ 384, 403 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T20", "type": "Procedure", "text": [ "barrier methods" ], "offsets": [ [ 406, 421 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T21", "type": "Observation", "text": [ "abstinence" ], "offsets": [ [ 425, 435 ] ], "normalized": [] }, { "id": "NCT03120728_inc_T22", "type": "Scope", "text": [ "sterilization (tubal ligation, Essure), copper IUD (intrauterine device), barrier methods or abstinence" ], "offsets": [ [ 332, 435 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03120728_inc_R1", "type": "Has_value", "arg1_id": "NCT03120728_inc_T3", "arg2_id": "NCT03120728_inc_T4", "normalized": [] }, { "id": "NCT03120728_inc_R2", "type": "Has_value", "arg1_id": "NCT03120728_inc_T5", "arg2_id": "NCT03120728_inc_T6", "normalized": [] }, { "id": "NCT03120728_inc_R3", "type": "AND", "arg1_id": "NCT03120728_inc_T7", "arg2_id": "NCT03120728_inc_T9", "normalized": [] }, { "id": "NCT03120728_inc_R4", "type": "Has_value", "arg1_id": "NCT03120728_inc_T9", "arg2_id": "NCT03120728_inc_T8", "normalized": [] }, { "id": "NCT03120728_inc_R5", "type": "Has_value", "arg1_id": "NCT03120728_inc_T11", "arg2_id": "NCT03120728_inc_T10", "normalized": [] }, { "id": "NCT03120728_inc_R6", "type": "Subsumes", "arg1_id": "NCT03120728_inc_T14", "arg2_id": "NCT03120728_inc_T17", "normalized": [] }, { "id": "NCT03120728_inc_R7", "type": "Subsumes", "arg1_id": "NCT03120728_inc_T18", "arg2_id": "NCT03120728_inc_T19", "normalized": [] }, { "id": "NCT03120728_inc_R8", "type": "Subsumes", "arg1_id": "NCT03120728_inc_T13", "arg2_id": "NCT03120728_inc_T22", "normalized": [] } ]

[ { "id": "NCT03122119_exc_text", "type": "exclusion", "text": [ "Patients under the age of 18 (Subjects under the age of 18 will not be included in this study due to the continued growth and development of their joints and unstudied effects on children.)\nOver the age of 80\nMultiple pain sources and multifactorial pain sources that complicated or confound diagnosing the SI joint as the primary and predominant pain generator that may contribute to low back pain (including but not limited to: lumbar diagnosis, lumbar radiculopathy, intra or extra-articular hip pathology to include acetabulum and femoral head, lumbo-sacral joint pathology, intervertebral disk disease, spondylolisthesis/spondylosis/spondylolysis of lumbar vertebra)\nImmunosuppressed/immune compromised\nUnderlying comorbidities that contraindicate the procedure (including but not limited to polycythemia, coagulation disorder, or malignancy).\n" ], "offsets": [ [ 0, 849 ] ] } ]

[ { "id": "NCT03122119_exc_T1", "type": "Person", "text": [ "age" ], "offsets": [ [ 19, 22 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T2", "type": "Value", "text": [ "18", "under" ], "offsets": [ [ 26, 28 ], [ 9, 14 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T4", "type": "Value", "text": [ "ver", "0" ], "offsets": [ [ 191, 194 ], [ 207, 208 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T5", "type": "Person", "text": [ "age" ], "offsets": [ [ 199, 202 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T6", "type": "Condition", "text": [ "Multiple pain sources" ], "offsets": [ [ 209, 230 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T7", "type": "Condition", "text": [ "multifactorial pain sources" ], "offsets": [ [ 235, 262 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T9", "type": "Condition", "text": [ "lumbar diagnosis" ], "offsets": [ [ 430, 446 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T10", "type": "Condition", "text": [ "lumbar radiculopathy" ], "offsets": [ [ 448, 468 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T11", "type": "Condition", "text": [ "extra-articular hip pathology" ], "offsets": [ [ 479, 508 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T12", "type": "Condition", "text": [ "tra o", "rticular hip pathology t" ], "offsets": [ [ 472, 477 ], [ 486, 510 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T13", "type": "Condition", "text": [ "etabulum a", "thology," ], "offsets": [ [ 522, 532 ], [ 570, 578 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T14", "type": "Condition", "text": [ "moral head,", "thology," ], "offsets": [ [ 537, 548 ], [ 570, 578 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T16", "type": "Condition", "text": [ "lumbo-sacral joint pathology" ], "offsets": [ [ 549, 577 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T15", "type": "Condition", "text": [ "intervertebral disk disease" ], "offsets": [ [ 579, 606 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T17", "type": "Condition", "text": [ "spondylolisthesis" ], "offsets": [ [ 608, 625 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T18", "type": "Condition", "text": [ "spondylosis" ], "offsets": [ [ 626, 637 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T19", "type": "Condition", "text": [ "spondylolysis of lumbar vertebra" ], "offsets": [ [ 638, 670 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T20", "type": "Scope", "text": [ "intra or extra-articular hip pathology" ], "offsets": [ [ 470, 508 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T21", "type": "Scope", "text": [ "acetabulum and femoral head, lumbo-sacral joint pathology, intervertebral disk disease, spondylolisthesis/spondylosis/spondylolysis of lumbar vertebra" ], "offsets": [ [ 520, 670 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T22", "type": "Scope", "text": [ "Multiple pain sources and multifactorial pain sources" ], "offsets": [ [ 209, 262 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T23", "type": "Scope", "text": [ "lumbar diagnosis, lumbar radiculopathy, intra or extra-articular hip pathology to include acetabulum and femoral head, lumbo-sacral joint pathology, intervertebral disk disease, spondylolisthesis/spondylosis/spondylolysis of lumbar vertebra" ], "offsets": [ [ 430, 670 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T24", "type": "Condition", "text": [ "Immunosuppressed" ], "offsets": [ [ 672, 688 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T25", "type": "Condition", "text": [ "immune compromised" ], "offsets": [ [ 689, 707 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T26", "type": "Condition", "text": [ "Underlying comorbidities" ], "offsets": [ [ 708, 732 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T27", "type": "Qualifier", "text": [ "contraindicate the procedure" ], "offsets": [ [ 738, 766 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T28", "type": "Condition", "text": [ "contraindicate" ], "offsets": [ [ 738, 752 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T29", "type": "Procedure", "text": [ "procedure" ], "offsets": [ [ 757, 766 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T30", "type": "Condition", "text": [ "polycythemia" ], "offsets": [ [ 797, 809 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T31", "type": "Condition", "text": [ "coagulation disorder" ], "offsets": [ [ 811, 831 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T32", "type": "Condition", "text": [ "malignancy" ], "offsets": [ [ 836, 846 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T33", "type": "Scope", "text": [ "polycythemia, coagulation disorder, or malignancy" ], "offsets": [ [ 797, 846 ] ], "normalized": [] }, { "id": "NCT03122119_exc_T34", "type": "Scope", "text": [ "Underlying comorbidities that contraindicate the procedure" ], "offsets": [ [ 708, 766 ] ], "normalized": [] } ]

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[ { "id": "NCT03122119_exc_R1", "type": "Has_value", "arg1_id": "NCT03122119_exc_T1", "arg2_id": "NCT03122119_exc_T2", "normalized": [] }, { "id": "NCT03122119_exc_R2", "type": "Has_value", "arg1_id": "NCT03122119_exc_T5", "arg2_id": "NCT03122119_exc_T4", "normalized": [] }, { "id": "NCT03122119_exc_R3", "type": "Subsumes", "arg1_id": "NCT03122119_exc_T20", "arg2_id": "NCT03122119_exc_T21", "normalized": [] }, { "id": "NCT03122119_exc_R4", "type": "Subsumes", "arg1_id": "NCT03122119_exc_T22", "arg2_id": "NCT03122119_exc_T23", "normalized": [] }, { "id": "NCT03122119_exc_R5", "type": "AND", "arg1_id": "NCT03122119_exc_T28", "arg2_id": "NCT03122119_exc_T29", "normalized": [] }, { "id": "NCT03122119_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03122119_exc_T26", "arg2_id": "NCT03122119_exc_T27", "normalized": [] }, { "id": "NCT03122119_exc_R7", "type": "Subsumes", "arg1_id": "NCT03122119_exc_T34", "arg2_id": "NCT03122119_exc_T33", "normalized": [] } ]

[ { "id": "NCT03122119_inc_text", "type": "inclusion", "text": [ "Diagnosis of sacroiliitis\nAge 18 to 80 years old\nChronic low back pain\nSI joint pathology is the predominant source of pain\nPositive Fortin Finger Test (PMT)\nJoint anatomy is identifiable using ultrasonography\nPatient has no other comorbidities that contraindicate the procedure\nPatient has attempted physical therapy and corticosteroid injections with local anesthetic -Previous injections of lidocaine and corticosteroid provided at least minor immediate relief\nPatient must not have had a corticosteroid injection in the SI joint within the last three months\nPatient must consent to the procedure\n" ], "offsets": [ [ 0, 600 ] ] } ]

[ { "id": "NCT03122119_inc_T1", "type": "Condition", "text": [ "sacroiliitis" ], "offsets": [ [ 13, 25 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T2", "type": "Person", "text": [ "Age" ], "offsets": [ [ 26, 29 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T3", "type": "Value", "text": [ "18 to 80 years" ], "offsets": [ [ 30, 44 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T4", "type": "Condition", "text": [ "Chronic low back pain" ], "offsets": [ [ 49, 70 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T5", "type": "Condition", "text": [ "SI joint pathology" ], "offsets": [ [ 71, 89 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T7", "type": "Value", "text": [ "Positive" ], "offsets": [ [ 124, 132 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T8", "type": "Measurement", "text": [ "Fortin Finger Test (PMT)" ], "offsets": [ [ 133, 157 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T10", "type": "Negation", "text": [ "no" ], "offsets": [ [ 222, 224 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T11", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 225, 230 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T12", "type": "Condition", "text": [ "comorbidities that contraindicate the procedure" ], "offsets": [ [ 231, 278 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T13", "type": "Procedure", "text": [ "physical therapy" ], "offsets": [ [ 301, 317 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T15", "type": "Procedure", "text": [ "corticosteroid injections" ], "offsets": [ [ 322, 347 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T14", "type": "Drug", "text": [ "ocal anesthetic" ], "offsets": [ [ 354, 369 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T17", "type": "Negation", "text": [ "not" ], "offsets": [ [ 477, 480 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T18", "type": "Procedure", "text": [ "corticosteroid injection" ], "offsets": [ [ 492, 516 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T19", "type": "Qualifier", "text": [ "SI joint" ], "offsets": [ [ 524, 532 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T20", "type": "Temporal", "text": [ "within the last three months" ], "offsets": [ [ 533, 561 ] ], "normalized": [] }, { "id": "NCT03122119_inc_T21", "type": "Observation", "text": [ "consent to the procedure" ], "offsets": [ [ 575, 599 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03122119_inc_R1", "type": "Has_value", "arg1_id": "NCT03122119_inc_T2", "arg2_id": "NCT03122119_inc_T3", "normalized": [] }, { "id": "NCT03122119_inc_R2", "type": "Has_value", "arg1_id": "NCT03122119_inc_T8", "arg2_id": "NCT03122119_inc_T7", "normalized": [] }, { "id": "NCT03122119_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03122119_inc_T12", "arg2_id": "NCT03122119_inc_T11", "normalized": [] }, { "id": "NCT03122119_inc_R4", "type": "Has_negation", "arg1_id": "NCT03122119_inc_T12", "arg2_id": "NCT03122119_inc_T10", "normalized": [] }, { "id": "NCT03122119_inc_R5", "type": "Has_qualifier", "arg1_id": "NCT03122119_inc_T18", "arg2_id": "NCT03122119_inc_T19", "normalized": [] }, { "id": "NCT03122119_inc_R6", "type": "AND", "arg1_id": "NCT03122119_inc_T15", "arg2_id": "NCT03122119_inc_T14", "normalized": [] }, { "id": "NCT03122119_inc_R7", "type": "Has_temporal", "arg1_id": "NCT03122119_inc_T18", "arg2_id": "NCT03122119_inc_T20", "normalized": [] }, { "id": "NCT03122119_inc_R8", "type": "Has_negation", "arg1_id": "NCT03122119_inc_T18", "arg2_id": "NCT03122119_inc_T17", "normalized": [] } ]

[ { "id": "NCT03123562_exc_text", "type": "exclusion", "text": [ "Epilepsy \nHydrocephalus with ventricular drain \nCoagulation disorders \nAllergy to anesthetic agents \nSevere health conditions such as cancer, failure of heart, lung, liver or kidney \nActive infections \n \n" ], "offsets": [ [ 0, 213 ] ] } ]

[ { "id": "NCT03123562_exc_T1", "type": "Condition", "text": [ "Epilepsy" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T2", "type": "Condition", "text": [ "Hydrocephalus" ], "offsets": [ [ 10, 23 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T3", "type": "Device", "text": [ "ventricular drain" ], "offsets": [ [ 29, 46 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T4", "type": "Condition", "text": [ "Coagulation disorders" ], "offsets": [ [ 48, 69 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T5", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 71, 78 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T6", "type": "Drug", "text": [ "anesthetic agents" ], "offsets": [ [ 82, 99 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T7", "type": "Condition", "text": [ "Severe health conditions" ], "offsets": [ [ 101, 125 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T10", "type": "Condition", "text": [ "cancer" ], "offsets": [ [ 134, 140 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T11", "type": "Condition", "text": [ "failure of heart" ], "offsets": [ [ 142, 158 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T12", "type": "Condition", "text": [ "failure of", "lung" ], "offsets": [ [ 142, 152 ], [ 160, 164 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T13", "type": "Condition", "text": [ "failure of", "liver" ], "offsets": [ [ 142, 152 ], [ 166, 171 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T14", "type": "Condition", "text": [ "failure of", "kidney" ], "offsets": [ [ 142, 152 ], [ 175, 181 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T15", "type": "Scope", "text": [ "cancer, failure of heart, lung, liver or kidney" ], "offsets": [ [ 134, 181 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T16", "type": "Condition", "text": [ "infections" ], "offsets": [ [ 190, 200 ] ], "normalized": [] }, { "id": "NCT03123562_exc_T18", "type": "Temporal", "text": [ "Active" ], "offsets": [ [ 183, 189 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03123562_exc_R1", "type": "AND", "arg1_id": "NCT03123562_exc_T2", "arg2_id": "NCT03123562_exc_T3", "normalized": [] }, { "id": "NCT03123562_exc_R2", "type": "AND", "arg1_id": "NCT03123562_exc_T5", "arg2_id": "NCT03123562_exc_T6", "normalized": [] }, { "id": "NCT03123562_exc_R3", "type": "Has_scope", "arg1_id": "NCT03123562_exc_T7", "arg2_id": "NCT03123562_exc_T15", "normalized": [] }, { "id": "NCT03123562_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03123562_exc_T16", "arg2_id": "NCT03123562_exc_T18", "normalized": [] } ]

[ { "id": "NCT03123562_inc_text", "type": "inclusion", "text": [ "Cerebral palsy of any types caused by Neonatal Jaundice \n" ], "offsets": [ [ 0, 57 ] ] } ]

[ { "id": "NCT03123562_inc_T1", "type": "Condition", "text": [ "Neonatal Jaundice" ], "offsets": [ [ 38, 55 ] ], "normalized": [] }, { "id": "NCT03123562_inc_T2", "type": "Condition", "text": [ "Cerebral palsy" ], "offsets": [ [ 0, 14 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03123562_inc_R1", "type": "AND", "arg1_id": "NCT03123562_inc_T2", "arg2_id": "NCT03123562_inc_T1", "normalized": [] } ]

[ { "id": "NCT03124329_exc_text", "type": "exclusion", "text": [ "Molar teeth \nMilller Class 4 recession defects \nPregnancy (Self-reported) \nSmoking \nUncontrolled local or systemic diseases that affects wound healing (diabetes, autoimmune or inflammatory disorders) \nPast history of systemic steroid use over 2 weeks within the last 2 years \nPoor oral hygiene on a non-compliant individual \nIbuprofen Allergy/interlerance \nAnticoagulant therapy (e.g. Warfarin, Plavix, etc.), will not be automatic exclusion but patients will be required to have INR test performed and have values between 2.0 to 3. Physician consultation will be requested to determine whether anticoagulant therapy can be discontinued for 3 days prior to surgery. \nObjection to blood draw or application of blood products \nStudents and staff from USC Ostrow school of Dentistry will not be recruited for this study \n \n" ], "offsets": [ [ 0, 829 ] ] } ]

[ { "id": "NCT03124329_exc_T1", "type": "Condition", "text": [ "Molar teeth" ], "offsets": [ [ 0, 11 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T2", "type": "Measurement", "text": [ "Milller" ], "offsets": [ [ 13, 20 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T3", "type": "Value", "text": [ "Class 4" ], "offsets": [ [ 21, 28 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T4", "type": "Condition", "text": [ "recession defects" ], "offsets": [ [ 29, 46 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T5", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 48, 57 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T7", "type": "Condition", "text": [ "Smoking" ], "offsets": [ [ 75, 82 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T8", "type": "Condition", "text": [ "diseases", "local" ], "offsets": [ [ 115, 123 ], [ 97, 102 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T9", "type": "Condition", "text": [ "systemic diseases" ], "offsets": [ [ 106, 123 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T10", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 84, 96 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T11", "type": "Scope", "text": [ "local or systemic diseases" ], "offsets": [ [ 97, 123 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T12", "type": "Qualifier", "text": [ "that affects wound healing" ], "offsets": [ [ 124, 150 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T13", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 152, 160 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T14", "type": "Condition", "text": [ "autoimmune", "disorders" ], "offsets": [ [ 162, 172 ], [ 189, 198 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T15", "type": "Condition", "text": [ "inflammatory disorders" ], "offsets": [ [ 176, 198 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T16", "type": "Scope", "text": [ "diabetes, autoimmune or inflammatory disorders" ], "offsets": [ [ 152, 198 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T17", "type": "Scope", "text": [ "Uncontrolled local or systemic diseases that affects wound healing" ], "offsets": [ [ 84, 150 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T18", "type": "Observation", "text": [ "Past history" ], "offsets": [ [ 201, 213 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T19", "type": "Drug", "text": [ "systemic steroid" ], "offsets": [ [ 217, 233 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T20", "type": "Temporal", "text": [ "over 2 weeks" ], "offsets": [ [ 238, 250 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T21", "type": "Temporal", "text": [ "within the last 2 years" ], "offsets": [ [ 251, 274 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T22", "type": "Condition", "text": [ "Poor oral hygiene" ], "offsets": [ [ 276, 293 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T23", "type": "Observation", "text": [ "non-compliant" ], "offsets": [ [ 299, 312 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T25", "type": "Drug", "text": [ "Ibuprofen" ], "offsets": [ [ 325, 334 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T26", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 335, 342 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T27", "type": "Condition", "text": [ "interlerance" ], "offsets": [ [ 343, 355 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T28", "type": "Procedure", "text": [ "Anticoagulant therapy" ], "offsets": [ [ 357, 378 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T29", "type": "Drug", "text": [ "Warfarin" ], "offsets": [ [ 385, 393 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T30", "type": "Drug", "text": [ "Plavix" ], "offsets": [ [ 395, 401 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T31", "type": "Scope", "text": [ "Warfarin, Plavix" ], "offsets": [ [ 385, 401 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T33", "type": "Measurement", "text": [ "INR test" ], "offsets": [ [ 480, 488 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T34", "type": "Value", "text": [ "between 2.0 to 3" ], "offsets": [ [ 515, 531 ] ], "normalized": [] }, { "id": "NCT03124329_exc_T35", "type": "Procedure", "text": [ "anticoagulant therapy" ], "offsets": [ [ 595, 616 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03124329_exc_R1", "type": "Has_value", "arg1_id": "NCT03124329_exc_T2", "arg2_id": "NCT03124329_exc_T3", "normalized": [] }, { "id": "NCT03124329_exc_R2", "type": "AND", "arg1_id": "NCT03124329_exc_T4", "arg2_id": "NCT03124329_exc_T2", "normalized": [] }, { "id": "NCT03124329_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03124329_exc_T11", "arg2_id": "NCT03124329_exc_T10", "normalized": [] }, { "id": "NCT03124329_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03124329_exc_T11", "arg2_id": "NCT03124329_exc_T12", "normalized": [] }, { "id": "NCT03124329_exc_R6", "type": "Subsumes", "arg1_id": "NCT03124329_exc_T17", "arg2_id": "NCT03124329_exc_T16", "normalized": [] }, { "id": "NCT03124329_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03124329_exc_T19", "arg2_id": "NCT03124329_exc_T18", "normalized": [] }, { "id": "NCT03124329_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03124329_exc_T19", "arg2_id": "NCT03124329_exc_T20", "normalized": [] }, { "id": "NCT03124329_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03124329_exc_T19", "arg2_id": "NCT03124329_exc_T21", "normalized": [] }, { "id": "NCT03124329_exc_R10", "type": "AND", "arg1_id": "NCT03124329_exc_T26", "arg2_id": "NCT03124329_exc_T25", "normalized": [] }, { "id": "NCT03124329_exc_R11", "type": "AND", "arg1_id": "NCT03124329_exc_T27", "arg2_id": "NCT03124329_exc_T25", "normalized": [] }, { "id": "NCT03124329_exc_R12", "type": "Subsumes", "arg1_id": "NCT03124329_exc_T28", "arg2_id": "NCT03124329_exc_T31", "normalized": [] }, { "id": "NCT03124329_exc_R13", "type": "Has_value", "arg1_id": "NCT03124329_exc_T33", "arg2_id": "NCT03124329_exc_T34", "normalized": [] }, { "id": "NCT03124329_exc_R14", "type": "AND", "arg1_id": "NCT03124329_exc_T28", "arg2_id": "NCT03124329_exc_T33", "normalized": [] } ]

[ { "id": "NCT03124329_inc_text", "type": "inclusion", "text": [ "Male and female individuals between ages of 18 to 70 years old \nMultiple contiguous gingival recession defects on a minimum of two adjacent teeth, exhibiting 3mm or more recession on at least one of those teeth \nNo prior surgical treatment in the sites planned for therapy \nMinimum of 2 mm of keratinized gingiva \nAbsence of cervical restorations extending to the CEJ \nMiller class 1, 2 and 3 recession defects will be included \nAvailability to undergo treatment and return for follow up visits at specified post-operative intervals \n" ], "offsets": [ [ 0, 534 ] ] } ]

[ { "id": "NCT03124329_inc_T1", "type": "Person", "text": [ "ages" ], "offsets": [ [ 36, 40 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T2", "type": "Value", "text": [ "between", "18 to 70 years old" ], "offsets": [ [ 28, 35 ], [ 44, 62 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T3", "type": "Condition", "text": [ "gingival recession defects" ], "offsets": [ [ 84, 110 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T4", "type": "Multiplier", "text": [ "Multiple" ], "offsets": [ [ 64, 72 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T5", "type": "Multiplier", "text": [ "minimum of two" ], "offsets": [ [ 116, 130 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T6", "type": "Value", "text": [ "3mm or more" ], "offsets": [ [ 158, 169 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T7", "type": "Measurement", "text": [ "recession" ], "offsets": [ [ 170, 179 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T8", "type": "Multiplier", "text": [ "at least one" ], "offsets": [ [ 183, 195 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T9", "type": "Procedure", "text": [ "surgical treatment" ], "offsets": [ [ 221, 239 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T10", "type": "Negation", "text": [ "No" ], "offsets": [ [ 212, 214 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T12", "type": "Value", "text": [ "Minimum of 2 mm" ], "offsets": [ [ 274, 289 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T13", "type": "Measurement", "text": [ "keratinized gingiva" ], "offsets": [ [ 293, 312 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T14", "type": "Observation", "text": [ "cervical restorations extending to the CEJ" ], "offsets": [ [ 325, 367 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T15", "type": "Negation", "text": [ "Absence" ], "offsets": [ [ 314, 321 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T16", "type": "Measurement", "text": [ "Miller" ], "offsets": [ [ 369, 375 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T17", "type": "Condition", "text": [ "recession defects" ], "offsets": [ [ 393, 410 ] ], "normalized": [] }, { "id": "NCT03124329_inc_T18", "type": "Value", "text": [ "class 1, 2 and 3" ], "offsets": [ [ 376, 392 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03124329_inc_R1", "type": "Has_value", "arg1_id": "NCT03124329_inc_T1", "arg2_id": "NCT03124329_inc_T2", "normalized": [] }, { "id": "NCT03124329_inc_R2", "type": "Has_multiplier", "arg1_id": "NCT03124329_inc_T3", "arg2_id": "NCT03124329_inc_T4", "normalized": [] }, { "id": "NCT03124329_inc_R3", "type": "Has_multiplier", "arg1_id": "NCT03124329_inc_T3", "arg2_id": "NCT03124329_inc_T5", "normalized": [] }, { "id": "NCT03124329_inc_R4", "type": "Has_value", "arg1_id": "NCT03124329_inc_T7", "arg2_id": "NCT03124329_inc_T6", "normalized": [] }, { "id": "NCT03124329_inc_R5", "type": "Has_multiplier", "arg1_id": "NCT03124329_inc_T7", "arg2_id": "NCT03124329_inc_T8", "normalized": [] }, { "id": "NCT03124329_inc_R6", "type": "AND", "arg1_id": "NCT03124329_inc_T3", "arg2_id": "NCT03124329_inc_T7", "normalized": [] }, { "id": "NCT03124329_inc_R7", "type": "Has_negation", "arg1_id": "NCT03124329_inc_T9", "arg2_id": "NCT03124329_inc_T10", "normalized": [] }, { "id": "NCT03124329_inc_R8", "type": "Has_value", "arg1_id": "NCT03124329_inc_T13", "arg2_id": "NCT03124329_inc_T12", "normalized": [] }, { "id": "NCT03124329_inc_R9", "type": "Has_negation", "arg1_id": "NCT03124329_inc_T14", "arg2_id": "NCT03124329_inc_T15", "normalized": [] }, { "id": "NCT03124329_inc_R10", "type": "AND", "arg1_id": "NCT03124329_inc_T17", "arg2_id": "NCT03124329_inc_T16", "normalized": [] } ]

[ { "id": "NCT03125057_exc_text", "type": "exclusion", "text": [ "Therapy area located outside of head and neck;\nOther skin diseases that might interfere with the efficacy evaluation;\nTherapy area was previously received isotope or PDT or other treatment which might interfere with the efficacy evaluation;\nAllergy to porphyrins and analogues; Photosensitivity; Porphyria; Allergic constitution;\nScar diathesis;\nImmunocompromised conditions;\nElectrocardiographic abnormalities or organic heart diseases;\nCoagulation disorders;\nHepatic or renal functions abnormal (alanine aminotransferase or aspartate transaminase or total bilirubin > 1.5 upper limit of normal [ULN], or serum creatinine or blood urea nitrogen > 1.5 ULN);\nPsychiatric diseases; Severe endocrinopathies;\nPrevious therapy of PWS within the last 4 weeks;\nParticipation in any clinical studies within the last 4 weeks;\nBe judged not suitable to participate the study by the investigators\n" ], "offsets": [ [ 0, 886 ] ] } ]

[ { "id": "NCT03125057_exc_T2", "type": "Condition", "text": [ "skin diseases" ], "offsets": [ [ 53, 66 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T3", "type": "Qualifier", "text": [ "interfere with the efficacy evaluation" ], "offsets": [ [ 78, 116 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T4", "type": "Drug", "text": [ "isotope" ], "offsets": [ [ 155, 162 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T5", "type": "Drug", "text": [ "PDT" ], "offsets": [ [ 166, 169 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T6", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 179, 188 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T7", "type": "Qualifier", "text": [ "might interfere with the efficacy evaluation" ], "offsets": [ [ 195, 239 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T8", "type": "Scope", "text": [ "isotope or PDT" ], "offsets": [ [ 155, 169 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T9", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 241, 248 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T10", "type": "Drug", "text": [ "porphyrins" ], "offsets": [ [ 252, 262 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T11", "type": "Condition", "text": [ "Photosensitivity" ], "offsets": [ [ 278, 294 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T12", "type": "Drug", "text": [ "analogues" ], "offsets": [ [ 267, 276 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T13", "type": "Condition", "text": [ "Porphyria" ], "offsets": [ [ 296, 305 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T14", "type": "Condition", "text": [ "Allergic constitution" ], "offsets": [ [ 307, 328 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T15", "type": "Scope", "text": [ "porphyrins and analogues" ], "offsets": [ [ 252, 276 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T16", "type": "Condition", "text": [ "Scar diathesis" ], "offsets": [ [ 330, 344 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T17", "type": "Condition", "text": [ "Immunocompromised conditions" ], "offsets": [ [ 346, 374 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T18", "type": "Condition", "text": [ "Electrocardiographic abnormalities" ], "offsets": [ [ 376, 410 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T19", "type": "Qualifier", "text": [ "organic" ], "offsets": [ [ 414, 421 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T20", "type": "Condition", "text": [ "heart diseases" ], "offsets": [ [ 422, 436 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T21", "type": "Procedure", "text": [ "Electrocardiographic" ], "offsets": [ [ 376, 396 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T22", "type": "Condition", "text": [ "Coagulation disorders" ], "offsets": [ [ 438, 459 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T23", "type": "Measurement", "text": [ "or rena", "s abnorma" ], "offsets": [ [ 469, 476 ], [ 486, 495 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T24", "type": "Measurement", "text": [ "renal functions" ], "offsets": [ [ 472, 487 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T25", "type": "Value", "text": [ "abnormal" ], "offsets": [ [ 488, 496 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T26", "type": "Measurement", "text": [ "alanine aminotransferase" ], "offsets": [ [ 498, 522 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T27", "type": "Measurement", "text": [ "aspartate transaminase" ], "offsets": [ [ 526, 548 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T28", "type": "Measurement", "text": [ "total bilirubin" ], "offsets": [ [ 552, 567 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T29", "type": "Value", "text": [ "> 1.5 upper limit of normal [ULN]" ], "offsets": [ [ 568, 601 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T30", "type": "Scope", "text": [ "alanine aminotransferase or aspartate transaminase or total bilirubin" ], "offsets": [ [ 498, 567 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T31", "type": "Measurement", "text": [ "serum creatinine" ], "offsets": [ [ 606, 622 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T32", "type": "Measurement", "text": [ "blood urea nitrogen" ], "offsets": [ [ 626, 645 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T33", "type": "Value", "text": [ "> 1.5 ULN" ], "offsets": [ [ 646, 655 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T34", "type": "Scope", "text": [ "serum creatinine or blood urea nitrogen" ], "offsets": [ [ 606, 645 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T35", "type": "Scope", "text": [ "alanine aminotransferase or aspartate transaminase or total bilirubin > 1.5 upper limit of normal [ULN], or serum creatinine or blood urea nitrogen > 1.5 ULN" ], "offsets": [ [ 498, 655 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T36", "type": "Scope", "text": [ "Hepatic or renal functions abnormal" ], "offsets": [ [ 461, 496 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T37", "type": "Condition", "text": [ "Psychiatric diseases" ], "offsets": [ [ 658, 678 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T38", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 680, 686 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T39", "type": "Condition", "text": [ "endocrinopathies" ], "offsets": [ [ 687, 703 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T40", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 705, 713 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T41", "type": "Procedure", "text": [ "therapy" ], "offsets": [ [ 714, 721 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T42", "type": "Temporal", "text": [ "within the last 4 weeks" ], "offsets": [ [ 729, 752 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T43", "type": "Observation", "text": [ "Participation in any clinical studies" ], "offsets": [ [ 754, 791 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T44", "type": "Temporal", "text": [ "within the last 4 weeks" ], "offsets": [ [ 792, 815 ] ], "normalized": [] }, { "id": "NCT03125057_exc_T46", "type": "Condition", "text": [ "PWS" ], "offsets": [ [ 725, 728 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03125057_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03125057_exc_T2", "arg2_id": "NCT03125057_exc_T3", "normalized": [] }, { "id": "NCT03125057_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03125057_exc_T6", "arg2_id": "NCT03125057_exc_T7", "normalized": [] }, { "id": "NCT03125057_exc_R3", "type": "Has_scope", "arg1_id": "NCT03125057_exc_T6", "arg2_id": "NCT03125057_exc_T8", "normalized": [] }, { "id": "NCT03125057_exc_R4", "type": "Has_scope", "arg1_id": "NCT03125057_exc_T9", "arg2_id": "NCT03125057_exc_T15", "normalized": [] }, { "id": "NCT03125057_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03125057_exc_T20", "arg2_id": "NCT03125057_exc_T19", "normalized": [] }, { "id": "NCT03125057_exc_R7", "type": "Has_value", "arg1_id": "NCT03125057_exc_T23", "arg2_id": "NCT03125057_exc_T25", "normalized": [] }, { "id": "NCT03125057_exc_R8", "type": "Has_value", "arg1_id": "NCT03125057_exc_T24", "arg2_id": "NCT03125057_exc_T25", "normalized": [] }, { "id": "NCT03125057_exc_R9", "type": "Has_value", "arg1_id": "NCT03125057_exc_T30", "arg2_id": "NCT03125057_exc_T29", "normalized": [] }, { "id": "NCT03125057_exc_R10", "type": "Has_value", "arg1_id": "NCT03125057_exc_T34", "arg2_id": "NCT03125057_exc_T33", "normalized": [] }, { "id": "NCT03125057_exc_R11", "type": "Subsumes", "arg1_id": "NCT03125057_exc_T36", "arg2_id": "NCT03125057_exc_T35", "normalized": [] }, { "id": "NCT03125057_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT03125057_exc_T39", "arg2_id": "NCT03125057_exc_T38", "normalized": [] }, { "id": "NCT03125057_exc_R13", "type": "Has_temporal", "arg1_id": "NCT03125057_exc_T41", "arg2_id": "NCT03125057_exc_T40", "normalized": [] }, { "id": "NCT03125057_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03125057_exc_T41", "arg2_id": "NCT03125057_exc_T42", "normalized": [] }, { "id": "NCT03125057_exc_R15", "type": "Has_temporal", "arg1_id": "NCT03125057_exc_T43", "arg2_id": "NCT03125057_exc_T44", "normalized": [] }, { "id": "NCT03125057_exc_R16", "type": "AND", "arg1_id": "NCT03125057_exc_T41", "arg2_id": "NCT03125057_exc_T46", "normalized": [] } ]

[ { "id": "NCT03125057_inc_text", "type": "inclusion", "text": [ "Children with clinical diagnosis of PWS;\nAge range: 7 to 14 years-old;\nVoluntarily participated and Written informed consent signed\n" ], "offsets": [ [ 0, 132 ] ] } ]

[ { "id": "NCT03125057_inc_T1", "type": "Person", "text": [ "Children" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03125057_inc_T2", "type": "Qualifier", "text": [ "clinical diagnosis" ], "offsets": [ [ 14, 32 ] ], "normalized": [] }, { "id": "NCT03125057_inc_T3", "type": "Condition", "text": [ "PWS" ], "offsets": [ [ 36, 39 ] ], "normalized": [] }, { "id": "NCT03125057_inc_T4", "type": "Person", "text": [ "Age" ], "offsets": [ [ 41, 44 ] ], "normalized": [] }, { "id": "NCT03125057_inc_T5", "type": "Value", "text": [ "7 to 14 years-old" ], "offsets": [ [ 52, 69 ] ], "normalized": [] }, { "id": "NCT03125057_inc_T6", "type": "Observation", "text": [ "Written informed consent signed" ], "offsets": [ [ 100, 131 ] ], "normalized": [] }, { "id": "NCT03125057_inc_T7", "type": "Observation", "text": [ "Voluntarily participated" ], "offsets": [ [ 71, 95 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03125057_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03125057_inc_T3", "arg2_id": "NCT03125057_inc_T2", "normalized": [] }, { "id": "NCT03125057_inc_R2", "type": "Has_value", "arg1_id": "NCT03125057_inc_T4", "arg2_id": "NCT03125057_inc_T5", "normalized": [] } ]

[ { "id": "NCT03126214_exc_text", "type": "exclusion", "text": [ "Uncontrolled hypertension (defined as average SBP = 160 mmHg [2 readings taken at time of screening]).\nEnd stage renal disease (CrCl < 15 ml/min)\nValvular Heart Disease including those with prosthetic valve, mitral stenosis (moderate to severe) or valve repair.\nExcess alcohol intake (males: = 28 units/week, females: = 21 units/week. One unit of alcohol = 8 oz beer, 1 oz hard liquor or 4 oz wine).\nIntracranial bleed at any point.\nHistory of \"Major Bleeding\" at any point (defined as overt bleeding at a critical site including intracranial, intraspinal, intraocular, pericardial, or retroperitoneal; or bleed requiring hospitalization).\nForeshortened life-expectancy or severe comorbidities precluding study follow-up period\nUnable to read/understand English\nSevere cognitive impairment (defined as score = 5 on the Short Portable Mental Status Questionnaire)\n" ], "offsets": [ [ 0, 863 ] ] } ]

[ { "id": "NCT03126214_exc_T1", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 13, 25 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T2", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T3", "type": "Measurement", "text": [ "average SBP" ], "offsets": [ [ 38, 49 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T4", "type": "Value", "text": [ "= 160 mmHg" ], "offsets": [ [ 50, 60 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T5", "type": "Multiplier", "text": [ "2 readings" ], "offsets": [ [ 62, 72 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T6", "type": "Temporal", "text": [ "at time of screening" ], "offsets": [ [ 79, 99 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T7", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 90, 99 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T8", "type": "Scope", "text": [ "average SBP = 160 mmHg [2 readings taken at time of screening]" ], "offsets": [ [ 38, 100 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T9", "type": "Scope", "text": [ "Uncontrolled hypertension" ], "offsets": [ [ 0, 25 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T10", "type": "Condition", "text": [ "End stage renal disease" ], "offsets": [ [ 103, 126 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T11", "type": "Measurement", "text": [ "CrCl" ], "offsets": [ [ 128, 132 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T12", "type": "Value", "text": [ "< 15 ml/min" ], "offsets": [ [ 133, 144 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T13", "type": "Scope", "text": [ "CrCl < 15 ml/min" ], "offsets": [ [ 128, 144 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T14", "type": "Condition", "text": [ "Valvular Heart Disease" ], "offsets": [ [ 146, 168 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T15", "type": "Device", "text": [ "prosthetic valve" ], "offsets": [ [ 190, 206 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T16", "type": "Condition", "text": [ "mitral stenosis" ], "offsets": [ [ 208, 223 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T17", "type": "Qualifier", "text": [ "moderate" ], "offsets": [ [ 225, 233 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T18", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 237, 243 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T19", "type": "Procedure", "text": [ "valve repair" ], "offsets": [ [ 248, 260 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T20", "type": "Scope", "text": [ "moderate to severe" ], "offsets": [ [ 225, 243 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T21", "type": "Measurement", "text": [ "alcohol intake" ], "offsets": [ [ 269, 283 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T22", "type": "Person", "text": [ "males" ], "offsets": [ [ 285, 290 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T23", "type": "Value", "text": [ "= 28 units/week" ], "offsets": [ [ 292, 307 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T24", "type": "Value", "text": [ "Excess" ], "offsets": [ [ 262, 268 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T25", "type": "Person", "text": [ "females" ], "offsets": [ [ 309, 316 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T26", "type": "Value", "text": [ "= 21 units/week" ], "offsets": [ [ 318, 333 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T28", "type": "Scope", "text": [ "males: = 28 units/week, females: = 21 units/week" ], "offsets": [ [ 285, 333 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T29", "type": "Condition", "text": [ "Intracranial bleed" ], "offsets": [ [ 400, 418 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T30", "type": "Temporal", "text": [ "at any point" ], "offsets": [ [ 419, 431 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T31", "type": "Condition", "text": [ "Major Bleeding" ], "offsets": [ [ 445, 459 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T32", "type": "Temporal", "text": [ "at any point" ], "offsets": [ [ 461, 473 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T33", "type": "Observation", "text": [ "History" ], "offsets": [ [ 433, 440 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T34", "type": "Condition", "text": [ "overt bleeding" ], "offsets": [ [ 486, 500 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T35", "type": "Qualifier", "text": [ "critical site" ], "offsets": [ [ 506, 519 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T36", "type": "Qualifier", "text": [ "intracranial" ], "offsets": [ [ 530, 542 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T37", "type": "Qualifier", "text": [ "intraspinal" ], "offsets": [ [ 544, 555 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T38", "type": "Qualifier", "text": [ "intraocular" ], "offsets": [ [ 557, 568 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T39", "type": "Qualifier", "text": [ "pericardial" ], "offsets": [ [ 570, 581 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T40", "type": "Qualifier", "text": [ "retroperitoneal" ], "offsets": [ [ 586, 601 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T41", "type": "Condition", "text": [ "bleed" ], "offsets": [ [ 606, 611 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T42", "type": "Procedure", "text": [ "hospitalization" ], "offsets": [ [ 622, 637 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T43", "type": "Scope", "text": [ "intracranial, intraspinal, intraocular, pericardial, or retroperitoneal" ], "offsets": [ [ 530, 601 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T44", "type": "Scope", "text": [ "overt bleeding at a critical site including intracranial, intraspinal, intraocular, pericardial, or retroperitoneal; or bleed requiring hospitalization" ], "offsets": [ [ 486, 637 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T45", "type": "Observation", "text": [ "life-expectancy" ], "offsets": [ [ 654, 669 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T46", "type": "Value", "text": [ "Foreshortened" ], "offsets": [ [ 640, 653 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T47", "type": "Condition", "text": [ "severe comorbidities" ], "offsets": [ [ 673, 693 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T49", "type": "Qualifier", "text": [ "Severe" ], "offsets": [ [ 762, 768 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T50", "type": "Condition", "text": [ "cognitive impairment" ], "offsets": [ [ 769, 789 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T51", "type": "Measurement", "text": [ "Short Portable Mental Status Questionnaire" ], "offsets": [ [ 819, 861 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T52", "type": "Value", "text": [ "= 5" ], "offsets": [ [ 808, 811 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T53", "type": "Scope", "text": [ "Severe cognitive impairment" ], "offsets": [ [ 762, 789 ] ], "normalized": [] }, { "id": "NCT03126214_exc_T54", "type": "Scope", "text": [ "= 5 on the Short Portable Mental Status Questionnaire" ], "offsets": [ [ 808, 861 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03126214_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03126214_exc_T1", "arg2_id": "NCT03126214_exc_T2", "normalized": [] }, { "id": "NCT03126214_exc_R2", "type": "Has_index", "arg1_id": "NCT03126214_exc_T6", "arg2_id": "NCT03126214_exc_T7", "normalized": [] }, { "id": "NCT03126214_exc_R3", "type": "Has_value", "arg1_id": "NCT03126214_exc_T3", "arg2_id": "NCT03126214_exc_T4", "normalized": [] }, { "id": "NCT03126214_exc_R4", "type": "Has_multiplier", "arg1_id": "NCT03126214_exc_T3", "arg2_id": "NCT03126214_exc_T5", "normalized": [] }, { "id": "NCT03126214_exc_R5", "type": "Has_temporal", "arg1_id": "NCT03126214_exc_T3", "arg2_id": "NCT03126214_exc_T6", "normalized": [] }, { "id": "NCT03126214_exc_R6", "type": "Subsumes", "arg1_id": "NCT03126214_exc_T9", "arg2_id": "NCT03126214_exc_T8", "normalized": [] }, { "id": "NCT03126214_exc_R7", "type": "Has_value", "arg1_id": "NCT03126214_exc_T11", "arg2_id": "NCT03126214_exc_T12", "normalized": [] }, { "id": "NCT03126214_exc_R8", "type": "Subsumes", "arg1_id": "NCT03126214_exc_T10", "arg2_id": "NCT03126214_exc_T13", "normalized": [] }, { "id": "NCT03126214_exc_R9", "type": "Subsumes", "arg1_id": "NCT03126214_exc_T16", "arg2_id": "NCT03126214_exc_T20", "normalized": [] }, { "id": "NCT03126214_exc_R10", "type": "Has_value", "arg1_id": "NCT03126214_exc_T21", "arg2_id": "NCT03126214_exc_T24", "normalized": [] }, { "id": "NCT03126214_exc_R11", "type": "Has_value", "arg1_id": "NCT03126214_exc_T22", "arg2_id": "NCT03126214_exc_T23", "normalized": [] }, { "id": "NCT03126214_exc_R12", "type": "Has_value", "arg1_id": "NCT03126214_exc_T25", "arg2_id": "NCT03126214_exc_T26", "normalized": [] }, { "id": "NCT03126214_exc_R13", "type": "Subsumes", "arg1_id": "NCT03126214_exc_T24", "arg2_id": "NCT03126214_exc_T28", "normalized": [] }, { "id": "NCT03126214_exc_R14", "type": "Has_temporal", "arg1_id": "NCT03126214_exc_T29", "arg2_id": "NCT03126214_exc_T30", "normalized": [] }, { "id": "NCT03126214_exc_R15", "type": "Has_temporal", "arg1_id": "NCT03126214_exc_T31", "arg2_id": "NCT03126214_exc_T32", "normalized": [] }, { "id": "NCT03126214_exc_R16", "type": "Has_temporal", "arg1_id": "NCT03126214_exc_T31", "arg2_id": "NCT03126214_exc_T33", "normalized": [] }, { "id": "NCT03126214_exc_R17", "type": "Has_qualifier", "arg1_id": "NCT03126214_exc_T34", "arg2_id": "NCT03126214_exc_T35", "normalized": [] }, { "id": "NCT03126214_exc_R18", "type": "AND", "arg1_id": "NCT03126214_exc_T41", "arg2_id": "NCT03126214_exc_T42", "normalized": [] }, { "id": "NCT03126214_exc_R19", "type": "Subsumes", "arg1_id": "NCT03126214_exc_T35", "arg2_id": "NCT03126214_exc_T43", "normalized": [] }, { "id": "NCT03126214_exc_R20", "type": "Subsumes", "arg1_id": "NCT03126214_exc_T31", "arg2_id": "NCT03126214_exc_T44", "normalized": [] }, { "id": "NCT03126214_exc_R21", "type": "Has_value", "arg1_id": "NCT03126214_exc_T45", "arg2_id": "NCT03126214_exc_T46", "normalized": [] }, { "id": "NCT03126214_exc_R22", "type": "Has_qualifier", "arg1_id": "NCT03126214_exc_T50", "arg2_id": "NCT03126214_exc_T49", "normalized": [] }, { "id": "NCT03126214_exc_R23", "type": "Has_value", "arg1_id": "NCT03126214_exc_T51", "arg2_id": "NCT03126214_exc_T52", "normalized": [] }, { "id": "NCT03126214_exc_R24", "type": "Subsumes", "arg1_id": "NCT03126214_exc_T53", "arg2_id": "NCT03126214_exc_T54", "normalized": [] } ]

[ { "id": "NCT03126214_inc_text", "type": "inclusion", "text": [ "Age = 65 years with one additional stroke risk factor (hypertension, diabetes, heart failure history of or left ventricular ejection fraction <0.40), previous stroke or transient ischemic attack).\nAtrial fibrillation and not on oral anticoagulation (OAC) therapy but eligible\nAtrial fibrillation on sub-optimal OAC\n" ], "offsets": [ [ 0, 315 ] ] } ]

[ { "id": "NCT03126214_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T2", "type": "Value", "text": [ "= 65 years" ], "offsets": [ [ 4, 14 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T3", "type": "Multiplier", "text": [ "one additional" ], "offsets": [ [ 20, 34 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T4", "type": "Condition", "text": [ "risk factor" ], "offsets": [ [ 42, 53 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T5", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 35, 41 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T6", "type": "Condition", "text": [ "hypertension" ], "offsets": [ [ 55, 67 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T7", "type": "Condition", "text": [ "diabetes" ], "offsets": [ [ 69, 77 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T8", "type": "Condition", "text": [ "heart failure" ], "offsets": [ [ 79, 92 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T9", "type": "Measurement", "text": [ "left ventricular ejection fraction" ], "offsets": [ [ 107, 141 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T10", "type": "Value", "text": [ "<0.40" ], "offsets": [ [ 142, 147 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T11", "type": "Observation", "text": [ "history" ], "offsets": [ [ 93, 100 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T12", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 150, 158 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T13", "type": "Condition", "text": [ "stroke" ], "offsets": [ [ 159, 165 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T14", "type": "Condition", "text": [ "transient ischemic attack" ], "offsets": [ [ 169, 194 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T15", "type": "Scope", "text": [ "stroke or transient ischemic attack" ], "offsets": [ [ 159, 194 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T16", "type": "Scope", "text": [ "hypertension, diabetes, heart failure history of or left ventricular ejection fraction <0.40), previous stroke or transient ischemic attack" ], "offsets": [ [ 55, 194 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T17", "type": "Scope", "text": [ "stroke risk factor" ], "offsets": [ [ 35, 53 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T18", "type": "Condition", "text": [ "Atrial fibrillation" ], "offsets": [ [ 197, 216 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T19", "type": "Measurement", "text": [ "not" ], "offsets": [ [ 221, 224 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T20", "type": "Procedure", "text": [ "oral anticoagulation (OAC) therapy" ], "offsets": [ [ 228, 262 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T22", "type": "Condition", "text": [ "Atrial fibrillation" ], "offsets": [ [ 276, 295 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T23", "type": "Procedure", "text": [ "OAC" ], "offsets": [ [ 311, 314 ] ], "normalized": [] }, { "id": "NCT03126214_inc_T24", "type": "Qualifier", "text": [ "sub-optimal" ], "offsets": [ [ 299, 310 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03126214_inc_R1", "type": "Has_value", "arg1_id": "NCT03126214_inc_T1", "arg2_id": "NCT03126214_inc_T2", "normalized": [] }, { "id": "NCT03126214_inc_R2", "type": "AND", "arg1_id": "NCT03126214_inc_T4", "arg2_id": "NCT03126214_inc_T5", "normalized": [] }, { "id": "NCT03126214_inc_R3", "type": "Has_value", "arg1_id": "NCT03126214_inc_T9", "arg2_id": "NCT03126214_inc_T10", "normalized": [] }, { "id": "NCT03126214_inc_R4", "type": "Has_temporal", "arg1_id": "NCT03126214_inc_T9", "arg2_id": "NCT03126214_inc_T11", "normalized": [] }, { "id": "NCT03126214_inc_R5", "type": "Has_temporal", "arg1_id": "NCT03126214_inc_T15", "arg2_id": "NCT03126214_inc_T12", "normalized": [] }, { "id": "NCT03126214_inc_R6", "type": "Subsumes", "arg1_id": "NCT03126214_inc_T17", "arg2_id": "NCT03126214_inc_T16", "normalized": [] }, { "id": "NCT03126214_inc_R7", "type": "Has_multiplier", "arg1_id": "NCT03126214_inc_T17", "arg2_id": "NCT03126214_inc_T3", "normalized": [] }, { "id": "NCT03126214_inc_R8", "type": "AND", "arg1_id": "NCT03126214_inc_T20", "arg2_id": "NCT03126214_inc_T19", "normalized": [] }, { "id": "NCT03126214_inc_R9", "type": "Has_qualifier", "arg1_id": "NCT03126214_inc_T23", "arg2_id": "NCT03126214_inc_T24", "normalized": [] } ]

[ { "id": "NCT03129555_exc_text", "type": "exclusion", "text": [ "A prescription of a NOAC within 90 days prior to hospitalization or outpatient clinic visit for VTE.\nPatients with NOAC preference apart from preference consistent with current cluster randomized NOAC.\nOther contraindications mentioned in the \"Summary of Product Characteristics\" for the respective NOAC.\n" ], "offsets": [ [ 0, 305 ] ] } ]

[ { "id": "NCT03129555_exc_T1", "type": "Drug", "text": [ "NOAC" ], "offsets": [ [ 20, 24 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T2", "type": "Temporal", "text": [ "within 90 days prior to hospitalization or outpatient clinic visit for VTE" ], "offsets": [ [ 25, 99 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T5", "type": "Condition", "text": [ "VTE" ], "offsets": [ [ 96, 99 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T3", "type": "Reference_point", "text": [ "hospitalization or outpatient clinic visit for VTE" ], "offsets": [ [ 49, 99 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T4", "type": "Procedure", "text": [ "hospitalization" ], "offsets": [ [ 49, 64 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T6", "type": "Procedure", "text": [ "outpatient clinic visit" ], "offsets": [ [ 68, 91 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T7", "type": "Visit", "text": [ "outpatient clinic" ], "offsets": [ [ 68, 85 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T8", "type": "Visit", "text": [ "hospitalization" ], "offsets": [ [ 49, 64 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T9", "type": "Scope", "text": [ "hospitalization or outpatient clinic visit for VTE" ], "offsets": [ [ 49, 99 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T10", "type": "Drug", "text": [ "NOAC" ], "offsets": [ [ 115, 119 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T11", "type": "Observation", "text": [ "NOAC preference" ], "offsets": [ [ 115, 130 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T13", "type": "Condition", "text": [ "contraindications" ], "offsets": [ [ 208, 225 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T14", "type": "Qualifier", "text": [ "Other" ], "offsets": [ [ 202, 207 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T15", "type": "Qualifier", "text": [ "Summary of Product Characteristics" ], "offsets": [ [ 244, 278 ] ], "normalized": [] }, { "id": "NCT03129555_exc_T16", "type": "Drug", "text": [ "NOAC" ], "offsets": [ [ 299, 303 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03129555_exc_R1", "type": "AND", "arg1_id": "NCT03129555_exc_T6", "arg2_id": "NCT03129555_exc_T5", "normalized": [] }, { "id": "NCT03129555_exc_R4", "type": "Has_index", "arg1_id": "NCT03129555_exc_T2", "arg2_id": "NCT03129555_exc_T3", "normalized": [] }, { "id": "NCT03129555_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03129555_exc_T1", "arg2_id": "NCT03129555_exc_T2", "normalized": [] }, { "id": "NCT03129555_exc_R8", "type": "Has_qualifier", "arg1_id": "NCT03129555_exc_T13", "arg2_id": "NCT03129555_exc_T14", "normalized": [] }, { "id": "NCT03129555_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03129555_exc_T13", "arg2_id": "NCT03129555_exc_T15", "normalized": [] }, { "id": "NCT03129555_exc_R10", "type": "AND", "arg1_id": "NCT03129555_exc_T13", "arg2_id": "NCT03129555_exc_T16", "normalized": [] } ]

[ { "id": "NCT03129555_inc_text", "type": "inclusion", "text": [ "A diagnosis of VTE in outpatient clinic or as discharge diagnosis after hospitalization.\nA claimed prescription of a NOAC from a Danish pharmacy within 14 days of discharge or outpatient clinic visit.\n" ], "offsets": [ [ 0, 201 ] ] } ]

[ { "id": "NCT03129555_inc_T1", "type": "Condition", "text": [ "VTE" ], "offsets": [ [ 15, 18 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T2", "type": "Visit", "text": [ "outpatient clinic" ], "offsets": [ [ 22, 39 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T3", "type": "Qualifier", "text": [ "discharge diagnosis" ], "offsets": [ [ 46, 65 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T4", "type": "Temporal", "text": [ "after hospitalization" ], "offsets": [ [ 66, 87 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T5", "type": "Reference_point", "text": [ "hospitalization" ], "offsets": [ [ 72, 87 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T6", "type": "Procedure", "text": [ "hospitalization" ], "offsets": [ [ 72, 87 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T7", "type": "Scope", "text": [ "outpatient clinic or as discharge diagnosis after hospitalization" ], "offsets": [ [ 22, 87 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T8", "type": "Procedure", "text": [ "prescription" ], "offsets": [ [ 99, 111 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T9", "type": "Drug", "text": [ "NOAC" ], "offsets": [ [ 117, 121 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T10", "type": "Qualifier", "text": [ "Danish pharmacy" ], "offsets": [ [ 129, 144 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T11", "type": "Temporal", "text": [ "within 14 days of discharge or outpatient clinic visit" ], "offsets": [ [ 145, 199 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T12", "type": "Reference_point", "text": [ "discharge or outpatient clinic visit" ], "offsets": [ [ 163, 199 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T13", "type": "Procedure", "text": [ "discharge" ], "offsets": [ [ 163, 172 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T14", "type": "Procedure", "text": [ "outpatient clinic visit" ], "offsets": [ [ 176, 199 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T15", "type": "Visit", "text": [ "outpatient clinic" ], "offsets": [ [ 176, 193 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T16", "type": "Scope", "text": [ "discharge or outpatient clinic visit" ], "offsets": [ [ 163, 199 ] ], "normalized": [] }, { "id": "NCT03129555_inc_T17", "type": "Qualifier", "text": [ "claimed" ], "offsets": [ [ 91, 98 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03129555_inc_R1", "type": "Has_temporal", "arg1_id": "NCT03129555_inc_T3", "arg2_id": "NCT03129555_inc_T4", "normalized": [] }, { "id": "NCT03129555_inc_R3", "type": "Has_index", "arg1_id": "NCT03129555_inc_T4", "arg2_id": "NCT03129555_inc_T5", "normalized": [] }, { "id": "NCT03129555_inc_R4", "type": "Has_scope", "arg1_id": "NCT03129555_inc_T1", "arg2_id": "NCT03129555_inc_T7", "normalized": [] }, { "id": "NCT03129555_inc_R6", "type": "Has_index", "arg1_id": "NCT03129555_inc_T11", "arg2_id": "NCT03129555_inc_T12", "normalized": [] }, { "id": "NCT03129555_inc_R8", "type": "Has_qualifier", "arg1_id": "NCT03129555_inc_T9", "arg2_id": "NCT03129555_inc_T10", "normalized": [] }, { "id": "NCT03129555_inc_R9", "type": "Has_temporal", "arg1_id": "NCT03129555_inc_T9", "arg2_id": "NCT03129555_inc_T11", "normalized": [] }, { "id": "NCT03129555_inc_R10", "type": "AND", "arg1_id": "NCT03129555_inc_T8", "arg2_id": "NCT03129555_inc_T9", "normalized": [] }, { "id": "NCT03129555_inc_R11", "type": "Has_qualifier", "arg1_id": "NCT03129555_inc_T8", "arg2_id": "NCT03129555_inc_T17", "normalized": [] } ]

[ { "id": "NCT03131050_exc_text", "type": "exclusion", "text": [ "Currently enrolled in, or discontinued within the last 30 days from, a clinical trial involving an off-label use of an investigational drug.\nCurrent Axis I primary psychiatric diagnosis other than major depressive disorder.\nOrganic mental disease, including mental retardation.\nHistory of clinically significant disease, including any cardiovascular, hepatic, renal, respiratory, hematologic, endocrinologic, or neurologic disease, or clinically significant laboratory abnormality that is not stabilized or is anticipated to require treatment during the study.\nSubjects receiving an investigational agent (including different formulation and generic agents of investigational drug) in the previous 3 months prior to screening.\nWomen in pregnancy or lactation, or female of child bearing potential without appropriate birth control measures.\nUse of antipsychotics or mood stabilizers within 5 days prior to screening.\nHas received depot antipsychotic medication within one cycle prior to screening.\nKnown allergy or lack of response to mirtazapine.\nHas received ECT or MECT within 3 months prior to screening.\nHistory of anticholinergic drug allergy or complications (allergic reaction, skin rash, urticaria and other allergic reactions which caused by drugs).\nSmokers.\nSignificant risk of suicidal and/or self-harm behaviors\n" ], "offsets": [ [ 0, 1325 ] ] } ]

[ { "id": "NCT03131050_exc_T2", "type": "Condition", "text": [ "psychiatric diagnosis" ], "offsets": [ [ 164, 185 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T3", "type": "Qualifier", "text": [ "primary" ], "offsets": [ [ 156, 163 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T4", "type": "Qualifier", "text": [ "Axis I" ], "offsets": [ [ 149, 155 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T5", "type": "Negation", "text": [ "other than" ], "offsets": [ [ 186, 196 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T6", "type": "Condition", "text": [ "major depressive disorder" ], "offsets": [ [ 197, 222 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T7", "type": "Condition", "text": [ "Organic mental disease" ], "offsets": [ [ 224, 246 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T8", "type": "Condition", "text": [ "mental retardation" ], "offsets": [ [ 258, 276 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T9", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 289, 311 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T10", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 312, 319 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T11", "type": "Condition", "text": [ "diovascular, h", "ease, o" ], "offsets": [ [ 338, 352 ], [ 426, 433 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T12", "type": "Condition", "text": [ "ocrinologic, o", "ease, o" ], "offsets": [ [ 396, 410 ], [ 426, 433 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T13", "type": "Condition", "text": [ "atologic, e", "ease, o" ], "offsets": [ [ 383, 394 ], [ 426, 433 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T14", "type": "Condition", "text": [ "piratory, h", "ease, o" ], "offsets": [ [ 370, 381 ], [ 426, 433 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T15", "type": "Condition", "text": [ "al, r", "ease, o" ], "offsets": [ [ 363, 368 ], [ 426, 433 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T16", "type": "Condition", "text": [ "atic, r", "ease, o" ], "offsets": [ [ 354, 361 ], [ 426, 433 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T17", "type": "Condition", "text": [ "neurologic disease" ], "offsets": [ [ 412, 430 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T18", "type": "Qualifier", "text": [ "clinically significant" ], "offsets": [ [ 435, 457 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T19", "type": "Condition", "text": [ "laboratory abnormality" ], "offsets": [ [ 458, 480 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T20", "type": "Negation", "text": [ "not" ], "offsets": [ [ 489, 492 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T21", "type": "Qualifier", "text": [ "stabilized" ], "offsets": [ [ 493, 503 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T22", "type": "Mood", "text": [ "anticipated to require" ], "offsets": [ [ 510, 532 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T23", "type": "Procedure", "text": [ "treatment" ], "offsets": [ [ 533, 542 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T24", "type": "Temporal", "text": [ "during the study" ], "offsets": [ [ 543, 559 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T25", "type": "Scope", "text": [ "not stabilized or is anticipated to require treatment during the study" ], "offsets": [ [ 489, 559 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T28", "type": "Drug", "text": [ "antipsychotics" ], "offsets": [ [ 848, 862 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T29", "type": "Drug", "text": [ "mood stabilizers" ], "offsets": [ [ 866, 882 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T30", "type": "Temporal", "text": [ "within 5 days prior to screening" ], "offsets": [ [ 883, 915 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T31", "type": "Scope", "text": [ "antipsychotics or mood stabilizers" ], "offsets": [ [ 848, 882 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T32", "type": "Drug", "text": [ "depot antipsychotic medication" ], "offsets": [ [ 930, 960 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T33", "type": "Temporal", "text": [ "within one cycle prior to screening" ], "offsets": [ [ 961, 996 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T34", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 1004, 1011 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T35", "type": "Condition", "text": [ "lack of response" ], "offsets": [ [ 1015, 1031 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T36", "type": "Drug", "text": [ "mirtazapine" ], "offsets": [ [ 1035, 1046 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T37", "type": "Scope", "text": [ "allergy or lack of response" ], "offsets": [ [ 1004, 1031 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T38", "type": "Temporal", "text": [ "within 3 months prior to screening" ], "offsets": [ [ 1073, 1107 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T39", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 987, 996 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T40", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 906, 915 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T41", "type": "Reference_point", "text": [ "screening" ], "offsets": [ [ 1098, 1107 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T42", "type": "Procedure", "text": [ "ECT" ], "offsets": [ [ 1069, 1072 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T43", "type": "Procedure", "text": [ "MECT" ], "offsets": [ [ 1068, 1072 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T44", "type": "Scope", "text": [ "ECT or MECT" ], "offsets": [ [ 1061, 1072 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T45", "type": "Drug", "text": [ "anticholinergic drug" ], "offsets": [ [ 1120, 1140 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T46", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 1141, 1148 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T47", "type": "Condition", "text": [ "allergic reaction" ], "offsets": [ [ 1167, 1184 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T48", "type": "Condition", "text": [ "skin rash" ], "offsets": [ [ 1186, 1195 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T49", "type": "Condition", "text": [ "urticaria" ], "offsets": [ [ 1197, 1206 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T50", "type": "Condition", "text": [ "allergic reactions" ], "offsets": [ [ 1217, 1235 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T51", "type": "Drug", "text": [ "drugs" ], "offsets": [ [ 1252, 1257 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T52", "type": "Qualifier", "text": [ "other" ], "offsets": [ [ 1211, 1216 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T53", "type": "Scope", "text": [ "allergic reaction, skin rash, urticaria and other allergic reactions" ], "offsets": [ [ 1167, 1235 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T54", "type": "Scope", "text": [ "allergic reaction, skin rash, urticaria and other allergic reactions which caused by drugs" ], "offsets": [ [ 1167, 1257 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T55", "type": "Scope", "text": [ "anticholinergic drug allergy" ], "offsets": [ [ 1120, 1148 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T56", "type": "Observation", "text": [ "Smokers" ], "offsets": [ [ 1260, 1267 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T57", "type": "Mood", "text": [ "risk of" ], "offsets": [ [ 1281, 1288 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T58", "type": "Observation", "text": [ "/or self", "" ], "offsets": [ [ 1301, 1309 ], [ 1327, 1327 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T59", "type": "Observation", "text": [ "self-harm behaviors" ], "offsets": [ [ 1305, 1324 ] ], "normalized": [] }, { "id": "NCT03131050_exc_T60", "type": "Scope", "text": [ "suicidal and/or self-harm behaviors" ], "offsets": [ [ 1289, 1324 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03131050_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03131050_exc_T2", "arg2_id": "NCT03131050_exc_T3", "normalized": [] }, { "id": "NCT03131050_exc_R2", "type": "Has_qualifier", "arg1_id": "NCT03131050_exc_T2", "arg2_id": "NCT03131050_exc_T4", "normalized": [] }, { "id": "NCT03131050_exc_R3", "type": "Has_negation", "arg1_id": "NCT03131050_exc_T6", "arg2_id": "NCT03131050_exc_T5", "normalized": [] }, { "id": "NCT03131050_exc_R4", "type": "AND", "arg1_id": "NCT03131050_exc_T2", "arg2_id": "NCT03131050_exc_T6", "normalized": [] }, { "id": "NCT03131050_exc_R5", "type": "Subsumes", "arg1_id": "NCT03131050_exc_T7", "arg2_id": "NCT03131050_exc_T8", "normalized": [] }, { "id": "NCT03131050_exc_R6", "type": "Has_qualifier", "arg1_id": "NCT03131050_exc_T10", "arg2_id": "NCT03131050_exc_T9", "normalized": [] }, { "id": "NCT03131050_exc_R7", "type": "Has_negation", "arg1_id": "NCT03131050_exc_T21", "arg2_id": "NCT03131050_exc_T20", "normalized": [] }, { "id": "NCT03131050_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03131050_exc_T23", "arg2_id": "NCT03131050_exc_T24", "normalized": [] }, { "id": "NCT03131050_exc_R9", "type": "Has_mood", "arg1_id": "NCT03131050_exc_T23", "arg2_id": "NCT03131050_exc_T22", "normalized": [] }, { "id": "NCT03131050_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03131050_exc_T19", "arg2_id": "NCT03131050_exc_T18", "normalized": [] }, { "id": "NCT03131050_exc_R11", "type": "Has_scope", "arg1_id": "NCT03131050_exc_T19", "arg2_id": "NCT03131050_exc_T25", "normalized": [] }, { "id": "NCT03131050_exc_R12", "type": "Has_temporal", "arg1_id": "NCT03131050_exc_T31", "arg2_id": "NCT03131050_exc_T30", "normalized": [] }, { "id": "NCT03131050_exc_R13", "type": "Has_temporal", "arg1_id": "NCT03131050_exc_T32", "arg2_id": "NCT03131050_exc_T33", "normalized": [] }, { "id": "NCT03131050_exc_R14", "type": "AND", "arg1_id": "NCT03131050_exc_T37", "arg2_id": "NCT03131050_exc_T36", "normalized": [] }, { "id": "NCT03131050_exc_R15", "type": "Has_index", "arg1_id": "NCT03131050_exc_T30", "arg2_id": "NCT03131050_exc_T40", "normalized": [] }, { "id": "NCT03131050_exc_R16", "type": "Has_index", "arg1_id": "NCT03131050_exc_T33", "arg2_id": "NCT03131050_exc_T39", "normalized": [] }, { "id": "NCT03131050_exc_R17", "type": "Has_index", "arg1_id": "NCT03131050_exc_T38", "arg2_id": "NCT03131050_exc_T41", "normalized": [] }, { "id": "NCT03131050_exc_R18", "type": "Has_temporal", "arg1_id": "NCT03131050_exc_T44", "arg2_id": "NCT03131050_exc_T38", "normalized": [] }, { "id": "NCT03131050_exc_R19", "type": "Has_qualifier", "arg1_id": "NCT03131050_exc_T50", "arg2_id": "NCT03131050_exc_T52", "normalized": [] }, { "id": "NCT03131050_exc_R20", "type": "AND", "arg1_id": "NCT03131050_exc_T53", "arg2_id": "NCT03131050_exc_T51", "normalized": [] }, { "id": "NCT03131050_exc_R21", "type": "AND", "arg1_id": "NCT03131050_exc_T46", "arg2_id": "NCT03131050_exc_T45", "normalized": [] }, { "id": "NCT03131050_exc_R22", "type": "Subsumes", "arg1_id": "NCT03131050_exc_T55", "arg2_id": "NCT03131050_exc_T54", "normalized": [] }, { "id": "NCT03131050_exc_R23", "type": "Has_mood", "arg1_id": "NCT03131050_exc_T60", "arg2_id": "NCT03131050_exc_T57", "normalized": [] } ]

[ { "id": "NCT03131050_inc_text", "type": "inclusion", "text": [ "Has given written informed consent.\nMale or female outpatients aged at least 18 years and not more than 45 years.\nHas a diagnosis of major depressive disorder by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria.\nCurrent HAMD-17 score = 20 and the duration of the index episode is greater than or equal to four weeks.\n" ], "offsets": [ [ 0, 356 ] ] } ]

[ { "id": "NCT03131050_inc_T2", "type": "Person", "text": [ "Male" ], "offsets": [ [ 36, 40 ] ], "normalized": [] }, { "id": "NCT03131050_inc_T3", "type": "Person", "text": [ "female" ], "offsets": [ [ 44, 50 ] ], "normalized": [] }, { "id": "NCT03131050_inc_T4", "type": "Visit", "text": [ "outpatients" ], "offsets": [ [ 51, 62 ] ], "normalized": [] }, { "id": "NCT03131050_inc_T5", "type": "Value", "text": [ "at least 18 years and not more than 45 years" ], "offsets": [ [ 68, 112 ] ], "normalized": [] }, { "id": "NCT03131050_inc_T6", "type": "Person", "text": [ "aged" ], "offsets": [ [ 63, 67 ] ], "normalized": [] }, { "id": "NCT03131050_inc_T7", "type": "Condition", "text": [ "major depressive disorder" ], "offsets": [ [ 133, 158 ] ], "normalized": [] }, { "id": "NCT03131050_inc_T8", "type": "Qualifier", "text": [ "Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria" ], "offsets": [ [ 162, 249 ] ], "normalized": [] }, { "id": "NCT03131050_inc_T9", "type": "Measurement", "text": [ "HAMD-17" ], "offsets": [ [ 259, 266 ] ], "normalized": [] }, { "id": "NCT03131050_inc_T10", "type": "Temporal", "text": [ "Current" ], "offsets": [ [ 251, 258 ] ], "normalized": [] }, { "id": "NCT03131050_inc_T11", "type": "Value", "text": [ "score = 20" ], "offsets": [ [ 267, 277 ] ], "normalized": [] }, { "id": "NCT03131050_inc_T12", "type": "Condition", "text": [ "index episode" ], "offsets": [ [ 302, 315 ] ], "normalized": [] }, { "id": "NCT03131050_inc_T13", "type": "Temporal", "text": [ "greater than or equal to four weeks" ], "offsets": [ [ 319, 354 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03131050_inc_R1", "type": "Has_value", "arg1_id": "NCT03131050_inc_T6", "arg2_id": "NCT03131050_inc_T5", "normalized": [] }, { "id": "NCT03131050_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03131050_inc_T7", "arg2_id": "NCT03131050_inc_T8", "normalized": [] }, { "id": "NCT03131050_inc_R3", "type": "Has_value", "arg1_id": "NCT03131050_inc_T9", "arg2_id": "NCT03131050_inc_T11", "normalized": [] }, { "id": "NCT03131050_inc_R4", "type": "Has_temporal", "arg1_id": "NCT03131050_inc_T9", "arg2_id": "NCT03131050_inc_T10", "normalized": [] }, { "id": "NCT03131050_inc_R5", "type": "Has_temporal", "arg1_id": "NCT03131050_inc_T12", "arg2_id": "NCT03131050_inc_T13", "normalized": [] } ]

[ { "id": "NCT03132259_exc_text", "type": "exclusion", "text": [ "GCS less than 15\nPreoperative Heart Rate less than 50 beat/min\nNo Beta-Blockers\nPregnant patients\nTake any Alpha-Methyldopa, Clonodine, Other Alpha-2 Adrenergic Agonist\nHemodynamic unstable\nSystolic BP more than 160mmHg\nCAD\nRenal insuffuciency\nAllergy in dexmedethomidine and opioid\nBMI more than 30\nDenied consent\n" ], "offsets": [ [ 0, 315 ] ] } ]

[ { "id": "NCT03132259_exc_T1", "type": "Measurement", "text": [ "GCS" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T2", "type": "Value", "text": [ "less than 15" ], "offsets": [ [ 4, 16 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T3", "type": "Measurement", "text": [ "Preoperative Heart Rate" ], "offsets": [ [ 17, 40 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T4", "type": "Value", "text": [ "less than 50 beat/min" ], "offsets": [ [ 41, 62 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T5", "type": "Negation", "text": [ "No" ], "offsets": [ [ 63, 65 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T6", "type": "Drug", "text": [ "Beta-Blockers" ], "offsets": [ [ 66, 79 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T7", "type": "Condition", "text": [ "Pregnant" ], "offsets": [ [ 80, 88 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T8", "type": "Drug", "text": [ "Alpha-Methyldopa" ], "offsets": [ [ 107, 123 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T9", "type": "Drug", "text": [ "Clonodine" ], "offsets": [ [ 125, 134 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T10", "type": "Qualifier", "text": [ "Other" ], "offsets": [ [ 136, 141 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T11", "type": "Drug", "text": [ "Alpha-2 Adrenergic Agonist" ], "offsets": [ [ 142, 168 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T12", "type": "Condition", "text": [ "Hemodynamic unstable" ], "offsets": [ [ 169, 189 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T13", "type": "Measurement", "text": [ "Systolic BP" ], "offsets": [ [ 190, 201 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T14", "type": "Value", "text": [ "more than 160mmHg" ], "offsets": [ [ 202, 219 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T15", "type": "Condition", "text": [ "CAD" ], "offsets": [ [ 220, 223 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T16", "type": "Condition", "text": [ "Renal insuffuciency" ], "offsets": [ [ 224, 243 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T17", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 244, 251 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T18", "type": "Drug", "text": [ "dexmedethomidine" ], "offsets": [ [ 255, 271 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T19", "type": "Drug", "text": [ "opioid" ], "offsets": [ [ 276, 282 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T20", "type": "Scope", "text": [ "dexmedethomidine and opioid" ], "offsets": [ [ 255, 282 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T21", "type": "Measurement", "text": [ "BMI" ], "offsets": [ [ 283, 286 ] ], "normalized": [] }, { "id": "NCT03132259_exc_T22", "type": "Value", "text": [ "more than 30" ], "offsets": [ [ 287, 299 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03132259_exc_R1", "type": "Has_value", "arg1_id": "NCT03132259_exc_T1", "arg2_id": "NCT03132259_exc_T2", "normalized": [] }, { "id": "NCT03132259_exc_R2", "type": "Has_negation", "arg1_id": "NCT03132259_exc_T6", "arg2_id": "NCT03132259_exc_T5", "normalized": [] }, { "id": "NCT03132259_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03132259_exc_T11", "arg2_id": "NCT03132259_exc_T10", "normalized": [] }, { "id": "NCT03132259_exc_R4", "type": "Has_value", "arg1_id": "NCT03132259_exc_T13", "arg2_id": "NCT03132259_exc_T14", "normalized": [] }, { "id": "NCT03132259_exc_R5", "type": "Has_scope", "arg1_id": "NCT03132259_exc_T17", "arg2_id": "NCT03132259_exc_T20", "normalized": [] }, { "id": "NCT03132259_exc_R6", "type": "Has_value", "arg1_id": "NCT03132259_exc_T21", "arg2_id": "NCT03132259_exc_T22", "normalized": [] } ]

[ { "id": "NCT03132259_inc_text", "type": "inclusion", "text": [ "Age18-65\nASA 1-2\nElective TNTS resection of Pituitary Tumor\nNo narcotic before surgery as premedication\nAble to Extubate\n" ], "offsets": [ [ 0, 121 ] ] } ]

[ { "id": "NCT03132259_inc_T1", "type": "Person", "text": [ "Age" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T2", "type": "Value", "text": [ "18-65" ], "offsets": [ [ 3, 8 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T3", "type": "Measurement", "text": [ "ASA" ], "offsets": [ [ 9, 12 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T4", "type": "Value", "text": [ "1-2" ], "offsets": [ [ 13, 16 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T5", "type": "Procedure", "text": [ "TNTS resection" ], "offsets": [ [ 26, 40 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T6", "type": "Condition", "text": [ "Pituitary Tumor" ], "offsets": [ [ 44, 59 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T7", "type": "Qualifier", "text": [ "Elective" ], "offsets": [ [ 17, 25 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T8", "type": "Negation", "text": [ "No" ], "offsets": [ [ 60, 62 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T9", "type": "Drug", "text": [ "narcotic" ], "offsets": [ [ 63, 71 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T10", "type": "Temporal", "text": [ "before surgery" ], "offsets": [ [ 72, 86 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T11", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 79, 86 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T12", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 79, 86 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T13", "type": "Mood", "text": [ "Able to" ], "offsets": [ [ 104, 111 ] ], "normalized": [] }, { "id": "NCT03132259_inc_T14", "type": "Procedure", "text": [ "Extubate" ], "offsets": [ [ 112, 120 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03132259_inc_R1", "type": "Has_value", "arg1_id": "NCT03132259_inc_T1", "arg2_id": "NCT03132259_inc_T2", "normalized": [] }, { "id": "NCT03132259_inc_R2", "type": "Has_value", "arg1_id": "NCT03132259_inc_T3", "arg2_id": "NCT03132259_inc_T4", "normalized": [] }, { "id": "NCT03132259_inc_R3", "type": "AND", "arg1_id": "NCT03132259_inc_T5", "arg2_id": "NCT03132259_inc_T6", "normalized": [] }, { "id": "NCT03132259_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03132259_inc_T5", "arg2_id": "NCT03132259_inc_T7", "normalized": [] }, { "id": "NCT03132259_inc_R5", "type": "Has_temporal", "arg1_id": "NCT03132259_inc_T9", "arg2_id": "NCT03132259_inc_T10", "normalized": [] }, { "id": "NCT03132259_inc_R6", "type": "Has_index", "arg1_id": "NCT03132259_inc_T10", "arg2_id": "NCT03132259_inc_T11", "normalized": [] }, { "id": "NCT03132259_inc_R8", "type": "Has_negation", "arg1_id": "NCT03132259_inc_T9", "arg2_id": "NCT03132259_inc_T8", "normalized": [] }, { "id": "NCT03132259_inc_R9", "type": "Has_mood", "arg1_id": "NCT03132259_inc_T14", "arg2_id": "NCT03132259_inc_T13", "normalized": [] } ]

[ { "id": "NCT03134196_exc_text", "type": "exclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT03134196_inc_text", "type": "inclusion", "text": [ "NA\n\n" ], "offsets": [ [ 0, 4 ] ] } ]

[]

[]

[]

[]

[ { "id": "NCT03134378_exc_text", "type": "exclusion", "text": [ "Patients refuse to follow the research\nPatient has had previous eradication therapy of Helicobacter pylori infection.\nThe patient is pregnant or breastfeeding\nPatients have a history of allergy to one component of triple therapy regimen (proton pump inhibitor, penicillin, and / or macrolide) before.\nPatients are known to have impaired liver function, evidenced by ALT values within normal limits, and no previous liver disease.\nPatients were found to have arrhythmias or obtained QT wave elongation on electrocardiographic\n" ], "offsets": [ [ 0, 525 ] ] } ]

[ { "id": "NCT03134378_exc_T1", "type": "Observation", "text": [ "refuse to follow the research" ], "offsets": [ [ 9, 38 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T2", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 55, 63 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T3", "type": "Procedure", "text": [ "eradication therapy" ], "offsets": [ [ 64, 83 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T4", "type": "Condition", "text": [ "Helicobacter pylori infection" ], "offsets": [ [ 87, 116 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T5", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 133, 141 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T6", "type": "Observation", "text": [ "breastfeeding" ], "offsets": [ [ 145, 158 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T7", "type": "Observation", "text": [ "history" ], "offsets": [ [ 175, 182 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T8", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 186, 193 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T9", "type": "Drug", "text": [ "component of triple therapy regimen" ], "offsets": [ [ 201, 236 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T10", "type": "Drug", "text": [ "proton pump inhibitor" ], "offsets": [ [ 238, 259 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T11", "type": "Drug", "text": [ "penicillin" ], "offsets": [ [ 261, 271 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T12", "type": "Drug", "text": [ "macrolide" ], "offsets": [ [ 282, 291 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T13", "type": "Scope", "text": [ "proton pump inhibitor, penicillin, and / or macrolide)" ], "offsets": [ [ 238, 292 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T14", "type": "Value", "text": [ "impaired" ], "offsets": [ [ 328, 336 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T15", "type": "Measurement", "text": [ "liver function" ], "offsets": [ [ 337, 351 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T16", "type": "Measurement", "text": [ "ALT values" ], "offsets": [ [ 366, 376 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T17", "type": "Value", "text": [ "within normal limits" ], "offsets": [ [ 377, 397 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T18", "type": "Negation", "text": [ "no" ], "offsets": [ [ 403, 405 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T19", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 406, 414 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T20", "type": "Condition", "text": [ "liver disease" ], "offsets": [ [ 415, 428 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T21", "type": "Condition", "text": [ "arrhythmias" ], "offsets": [ [ 458, 469 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T22", "type": "Condition", "text": [ "QT wave elongation" ], "offsets": [ [ 482, 500 ] ], "normalized": [] }, { "id": "NCT03134378_exc_T23", "type": "Procedure", "text": [ "electrocardiographic" ], "offsets": [ [ 504, 524 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03134378_exc_R1", "type": "AND", "arg1_id": "NCT03134378_exc_T3", "arg2_id": "NCT03134378_exc_T4", "normalized": [] }, { "id": "NCT03134378_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03134378_exc_T3", "arg2_id": "NCT03134378_exc_T2", "normalized": [] }, { "id": "NCT03134378_exc_R3", "type": "AND", "arg1_id": "NCT03134378_exc_T8", "arg2_id": "NCT03134378_exc_T9", "normalized": [] }, { "id": "NCT03134378_exc_R4", "type": "Has_temporal", "arg1_id": "NCT03134378_exc_T8", "arg2_id": "NCT03134378_exc_T7", "normalized": [] }, { "id": "NCT03134378_exc_R5", "type": "Subsumes", "arg1_id": "NCT03134378_exc_T9", "arg2_id": "NCT03134378_exc_T13", "normalized": [] }, { "id": "NCT03134378_exc_R6", "type": "Has_value", "arg1_id": "NCT03134378_exc_T15", "arg2_id": "NCT03134378_exc_T14", "normalized": [] }, { "id": "NCT03134378_exc_R7", "type": "Has_value", "arg1_id": "NCT03134378_exc_T16", "arg2_id": "NCT03134378_exc_T17", "normalized": [] }, { "id": "NCT03134378_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03134378_exc_T20", "arg2_id": "NCT03134378_exc_T19", "normalized": [] }, { "id": "NCT03134378_exc_R9", "type": "Has_negation", "arg1_id": "NCT03134378_exc_T20", "arg2_id": "NCT03134378_exc_T18", "normalized": [] }, { "id": "NCT03134378_exc_R10", "type": "AND", "arg1_id": "NCT03134378_exc_T23", "arg2_id": "NCT03134378_exc_T22", "normalized": [] } ]

[ { "id": "NCT03134378_inc_text", "type": "inclusion", "text": [ "18 years or older patients who are proven to be infected by Helicobacter pylori based on positive in Urea Breath Test or positive in histopathologic examination of biopsy in antrum and corpus of gaster through esophagoduodenoscopy.\n" ], "offsets": [ [ 0, 232 ] ] } ]

[ { "id": "NCT03134378_inc_T1", "type": "Value", "text": [ "18 years or older" ], "offsets": [ [ 0, 17 ] ], "normalized": [] }, { "id": "NCT03134378_inc_T2", "type": "Condition", "text": [ "infected by Helicobacter pylori" ], "offsets": [ [ 48, 79 ] ], "normalized": [] }, { "id": "NCT03134378_inc_T3", "type": "Value", "text": [ "positive" ], "offsets": [ [ 89, 97 ] ], "normalized": [] }, { "id": "NCT03134378_inc_T4", "type": "Measurement", "text": [ "Urea Breath Test" ], "offsets": [ [ 101, 117 ] ], "normalized": [] }, { "id": "NCT03134378_inc_T5", "type": "Value", "text": [ "positive" ], "offsets": [ [ 121, 129 ] ], "normalized": [] }, { "id": "NCT03134378_inc_T6", "type": "Procedure", "text": [ "histopathologic examination of biopsy" ], "offsets": [ [ 133, 170 ] ], "normalized": [] }, { "id": "NCT03134378_inc_T7", "type": "Qualifier", "text": [ "antrum", "of gaster" ], "offsets": [ [ 174, 180 ], [ 192, 201 ] ], "normalized": [] }, { "id": "NCT03134378_inc_T8", "type": "Qualifier", "text": [ "corpus of gaster" ], "offsets": [ [ 185, 201 ] ], "normalized": [] }, { "id": "NCT03134378_inc_T9", "type": "Procedure", "text": [ "esophagoduodenoscopy" ], "offsets": [ [ 210, 230 ] ], "normalized": [] }, { "id": "NCT03134378_inc_T10", "type": "Person", "text": [ "old" ], "offsets": [ [ 12, 15 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03134378_inc_R1", "type": "Has_value", "arg1_id": "NCT03134378_inc_T4", "arg2_id": "NCT03134378_inc_T3", "normalized": [] }, { "id": "NCT03134378_inc_R2", "type": "Has_value", "arg1_id": "NCT03134378_inc_T6", "arg2_id": "NCT03134378_inc_T5", "normalized": [] }, { "id": "NCT03134378_inc_R3", "type": "Has_qualifier", "arg1_id": "NCT03134378_inc_T6", "arg2_id": "NCT03134378_inc_T7", "normalized": [] }, { "id": "NCT03134378_inc_R4", "type": "Has_qualifier", "arg1_id": "NCT03134378_inc_T6", "arg2_id": "NCT03134378_inc_T8", "normalized": [] }, { "id": "NCT03134378_inc_R5", "type": "AND", "arg1_id": "NCT03134378_inc_T9", "arg2_id": "NCT03134378_inc_T6", "normalized": [] }, { "id": "NCT03134378_inc_R6", "type": "Has_value", "arg1_id": "NCT03134378_inc_T10", "arg2_id": "NCT03134378_inc_T1", "normalized": [] } ]

[ { "id": "NCT03138577_exc_text", "type": "exclusion", "text": [ "Patient refusal for supraclavicular block\nInability to give informed consent\nAllergy to local anesthetics\nHemidiaphragmatic dysfunction, suspected or known PNP\nNeuromuscular disease\nObstructive or restrictive pulmonary disease\nMedical or anatomic contraindication to supraclavicular blockade as judged by clinician\nPregnancy\n" ], "offsets": [ [ 0, 325 ] ] } ]

[ { "id": "NCT03138577_exc_T1", "type": "Observation", "text": [ "Patient refusal" ], "offsets": [ [ 0, 15 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T2", "type": "Procedure", "text": [ "supraclavicular block" ], "offsets": [ [ 20, 41 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T3", "type": "Observation", "text": [ "Inability to give informed consent" ], "offsets": [ [ 42, 76 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T4", "type": "Condition", "text": [ "Allergy" ], "offsets": [ [ 77, 84 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T5", "type": "Drug", "text": [ "local anesthetics" ], "offsets": [ [ 88, 105 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T6", "type": "Condition", "text": [ "Hemidiaphragmatic dysfunction" ], "offsets": [ [ 106, 135 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T7", "type": "Condition", "text": [ "PNP" ], "offsets": [ [ 156, 159 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T8", "type": "Qualifier", "text": [ "known" ], "offsets": [ [ 150, 155 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T9", "type": "Qualifier", "text": [ "suspected" ], "offsets": [ [ 137, 146 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T10", "type": "Scope", "text": [ "suspected or known" ], "offsets": [ [ 137, 155 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T11", "type": "Condition", "text": [ "Neuromuscular disease" ], "offsets": [ [ 160, 181 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T12", "type": "Condition", "text": [ "restrictive pulmonary disease" ], "offsets": [ [ 197, 226 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T13", "type": "Condition", "text": [ "uctive or r", "nary disease\nMedi" ], "offsets": [ [ 187, 198 ], [ 214, 231 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T14", "type": "Qualifier", "text": [ "anatomic" ], "offsets": [ [ 238, 246 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T15", "type": "Qualifier", "text": [ "Medical" ], "offsets": [ [ 227, 234 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T16", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 247, 263 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T17", "type": "Procedure", "text": [ "supraclavicular blockade" ], "offsets": [ [ 267, 291 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T18", "type": "Scope", "text": [ "Medical or anatomic" ], "offsets": [ [ 227, 246 ] ], "normalized": [] }, { "id": "NCT03138577_exc_T20", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 315, 324 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03138577_exc_R1", "type": "AND", "arg1_id": "NCT03138577_exc_T1", "arg2_id": "NCT03138577_exc_T2", "normalized": [] }, { "id": "NCT03138577_exc_R2", "type": "AND", "arg1_id": "NCT03138577_exc_T4", "arg2_id": "NCT03138577_exc_T5", "normalized": [] }, { "id": "NCT03138577_exc_R3", "type": "Has_scope", "arg1_id": "NCT03138577_exc_T7", "arg2_id": "NCT03138577_exc_T10", "normalized": [] }, { "id": "NCT03138577_exc_R4", "type": "Has_scope", "arg1_id": "NCT03138577_exc_T16", "arg2_id": "NCT03138577_exc_T18", "normalized": [] }, { "id": "NCT03138577_exc_R5", "type": "AND", "arg1_id": "NCT03138577_exc_T16", "arg2_id": "NCT03138577_exc_T17", "normalized": [] } ]

[ { "id": "NCT03138577_inc_text", "type": "inclusion", "text": [ "Undergoing right upper extremity surgery with supraclavicular block as the primary anesthetic\nAge greater than or equal to 18 years of age\nAmerican Society of Anesthesiologists (ASA) physical status 1 to 3\nAble to give informed consent\n" ], "offsets": [ [ 0, 236 ] ] } ]

[ { "id": "NCT03138577_inc_T1", "type": "Temporal", "text": [ "Undergoing" ], "offsets": [ [ 0, 10 ] ], "normalized": [] }, { "id": "NCT03138577_inc_T2", "type": "Procedure", "text": [ "right upper extremity surgery" ], "offsets": [ [ 11, 40 ] ], "normalized": [] }, { "id": "NCT03138577_inc_T3", "type": "Procedure", "text": [ "supraclavicular block" ], "offsets": [ [ 46, 67 ] ], "normalized": [] }, { "id": "NCT03138577_inc_T4", "type": "Qualifier", "text": [ "primary anesthetic" ], "offsets": [ [ 75, 93 ] ], "normalized": [] }, { "id": "NCT03138577_inc_T5", "type": "Person", "text": [ "Age" ], "offsets": [ [ 94, 97 ] ], "normalized": [] }, { "id": "NCT03138577_inc_T6", "type": "Value", "text": [ "greater than or equal to 18 years" ], "offsets": [ [ 98, 131 ] ], "normalized": [] }, { "id": "NCT03138577_inc_T7", "type": "Measurement", "text": [ "American Society of Anesthesiologists (ASA) physical status" ], "offsets": [ [ 139, 198 ] ], "normalized": [] }, { "id": "NCT03138577_inc_T8", "type": "Value", "text": [ "1 to 3" ], "offsets": [ [ 199, 205 ] ], "normalized": [] }, { "id": "NCT03138577_inc_T9", "type": "Observation", "text": [ "Able to give informed consent" ], "offsets": [ [ 206, 235 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03138577_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03138577_inc_T3", "arg2_id": "NCT03138577_inc_T4", "normalized": [] }, { "id": "NCT03138577_inc_R2", "type": "AND", "arg1_id": "NCT03138577_inc_T2", "arg2_id": "NCT03138577_inc_T3", "normalized": [] }, { "id": "NCT03138577_inc_R3", "type": "Has_temporal", "arg1_id": "NCT03138577_inc_T2", "arg2_id": "NCT03138577_inc_T1", "normalized": [] }, { "id": "NCT03138577_inc_R4", "type": "Has_value", "arg1_id": "NCT03138577_inc_T5", "arg2_id": "NCT03138577_inc_T6", "normalized": [] } ]

[ { "id": "NCT03140423_exc_text", "type": "exclusion", "text": [ "Exclusion criteria includes ICUs with an average length of stay of less than 2 days;\nHCA hospitals that are not able to transfer or merge data into the centralized data warehouse for the baseline and intervention periods of the study are also excluded.\n" ], "offsets": [ [ 0, 253 ] ] } ]

[ { "id": "NCT03140423_exc_T1", "type": "Visit", "text": [ "ICUs" ], "offsets": [ [ 28, 32 ] ], "normalized": [] }, { "id": "NCT03140423_exc_T2", "type": "Measurement", "text": [ "average length of stay" ], "offsets": [ [ 41, 63 ] ], "normalized": [] }, { "id": "NCT03140423_exc_T3", "type": "Value", "text": [ "less than 2 days" ], "offsets": [ [ 67, 83 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03140423_exc_R1", "type": "Has_value", "arg1_id": "NCT03140423_exc_T2", "arg2_id": "NCT03140423_exc_T3", "normalized": [] }, { "id": "NCT03140423_exc_R2", "type": "AND", "arg1_id": "NCT03140423_exc_T1", "arg2_id": "NCT03140423_exc_T2", "normalized": [] } ]

[ { "id": "NCT03140423_inc_text", "type": "inclusion", "text": [ "Inclusion criteria includes all U.S. HCA hospitals with an adult ICU;\nNote: Unit of randomization is the hospital, but the participants are hospital adult ICUs\nAll patients within adult ICUs are included, including rare patients <18 years and >=12 years.\n" ], "offsets": [ [ 0, 255 ] ] } ]

[ { "id": "NCT03140423_inc_T1", "type": "Visit", "text": [ "U.S." ], "offsets": [ [ 32, 36 ] ], "normalized": [] }, { "id": "NCT03140423_inc_T2", "type": "Visit", "text": [ "HCA hospitals" ], "offsets": [ [ 37, 50 ] ], "normalized": [] }, { "id": "NCT03140423_inc_T3", "type": "Person", "text": [ "adult" ], "offsets": [ [ 59, 64 ] ], "normalized": [] }, { "id": "NCT03140423_inc_T4", "type": "Visit", "text": [ "adult ICU" ], "offsets": [ [ 59, 68 ] ], "normalized": [] }, { "id": "NCT03140423_inc_T6", "type": "Visit", "text": [ "adult ICUs" ], "offsets": [ [ 180, 190 ] ], "normalized": [] }, { "id": "NCT03140423_inc_T7", "type": "Person", "text": [ "adult" ], "offsets": [ [ 180, 185 ] ], "normalized": [] }, { "id": "NCT03140423_inc_T8", "type": "Person", "text": [ "rare patients" ], "offsets": [ [ 215, 228 ] ], "normalized": [] }, { "id": "NCT03140423_inc_T9", "type": "Value", "text": [ "<18 years and >=12 years" ], "offsets": [ [ 229, 253 ] ], "normalized": [] }, { "id": "NCT03140423_inc_T10", "type": "Person", "text": [ "year" ], "offsets": [ [ 233, 237 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03140423_inc_R2", "type": "AND", "arg1_id": "NCT03140423_inc_T2", "arg2_id": "NCT03140423_inc_T1", "normalized": [] }, { "id": "NCT03140423_inc_R3", "type": "AND", "arg1_id": "NCT03140423_inc_T2", "arg2_id": "NCT03140423_inc_T4", "normalized": [] }, { "id": "NCT03140423_inc_R5", "type": "Has_value", "arg1_id": "NCT03140423_inc_T10", "arg2_id": "NCT03140423_inc_T9", "normalized": [] } ]

[ { "id": "NCT03140488_exc_text", "type": "exclusion", "text": [ "Non-reassuring fetal assessment at the time of recruitment\nPrevious cervical ripening agents (cytotec, cervidil, cervical Foley Balloon)\n<18 years of age\nPrisoners\nAny patients contraindicated for vaginal delivery\nMultiple gestations\nHistory of previous cesarean delivery\nPatients with history of significant cardiac disease\nFetal demise\nEstimated fetal weight greater than 4500 grams in diabetic and 5000 grams in non-diabetic mother\nRuptured membranes\nSpontaneous labor (latent or active phase)\nAugmentation of labor (latent or active phase)\n" ], "offsets": [ [ 0, 544 ] ] } ]

[ { "id": "NCT03140488_exc_T1", "type": "Value", "text": [ "Non-reassuring" ], "offsets": [ [ 0, 14 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T2", "type": "Measurement", "text": [ "fetal assessment" ], "offsets": [ [ 15, 31 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T3", "type": "Temporal", "text": [ "at the time of recruitment" ], "offsets": [ [ 32, 58 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T4", "type": "Temporal", "text": [ "Previous" ], "offsets": [ [ 59, 67 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T5", "type": "Drug", "text": [ "cervical ripening agents" ], "offsets": [ [ 68, 92 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T6", "type": "Drug", "text": [ "cytotec" ], "offsets": [ [ 94, 101 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T7", "type": "Drug", "text": [ "cervidil" ], "offsets": [ [ 103, 111 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T8", "type": "Device", "text": [ "cervical Foley Balloon" ], "offsets": [ [ 113, 135 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T9", "type": "Scope", "text": [ "cytotec, cervidil, cervical Foley Balloon" ], "offsets": [ [ 94, 135 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T10", "type": "Person", "text": [ "age" ], "offsets": [ [ 150, 153 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T11", "type": "Value", "text": [ "<18 years" ], "offsets": [ [ 137, 146 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T12", "type": "Person", "text": [ "Prisoners" ], "offsets": [ [ 154, 163 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T13", "type": "Condition", "text": [ "contraindicated" ], "offsets": [ [ 177, 192 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T14", "type": "Procedure", "text": [ "vaginal delivery" ], "offsets": [ [ 197, 213 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T15", "type": "Observation", "text": [ "Multiple gestations" ], "offsets": [ [ 214, 233 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T16", "type": "Observation", "text": [ "History" ], "offsets": [ [ 234, 241 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T17", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 245, 253 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T18", "type": "Procedure", "text": [ "cesarean delivery" ], "offsets": [ [ 254, 271 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T19", "type": "Observation", "text": [ "history" ], "offsets": [ [ 286, 293 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T20", "type": "Qualifier", "text": [ "significant" ], "offsets": [ [ 297, 308 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T21", "type": "Condition", "text": [ "cardiac disease" ], "offsets": [ [ 309, 324 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T22", "type": "Condition", "text": [ "Fetal demise" ], "offsets": [ [ 325, 337 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T23", "type": "Measurement", "text": [ "Estimated fetal weight" ], "offsets": [ [ 338, 360 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T24", "type": "Value", "text": [ "greater than 4500 grams" ], "offsets": [ [ 361, 384 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T25", "type": "Condition", "text": [ "diabetic" ], "offsets": [ [ 388, 396 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T26", "type": "Value", "text": [ "5000 grams" ], "offsets": [ [ 401, 411 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T27", "type": "Negation", "text": [ "non-" ], "offsets": [ [ 415, 419 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T28", "type": "Condition", "text": [ "diabetic" ], "offsets": [ [ 419, 427 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T29", "type": "Scope", "text": [ "non-diabetic" ], "offsets": [ [ 415, 427 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T30", "type": "Scope", "text": [ "greater than 4500 grams in diabetic and 5000 grams in non-diabetic" ], "offsets": [ [ 361, 427 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T31", "type": "Condition", "text": [ "Ruptured membranes" ], "offsets": [ [ 435, 453 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T32", "type": "Condition", "text": [ "Spontaneous labor" ], "offsets": [ [ 454, 471 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T33", "type": "Qualifier", "text": [ "ctive", "entat" ], "offsets": [ [ 484, 489 ], [ 501, 506 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T34", "type": "Qualifier", "text": [ "active phase" ], "offsets": [ [ 483, 495 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T35", "type": "Scope", "text": [ "latent or active phase" ], "offsets": [ [ 473, 495 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T36", "type": "Condition", "text": [ "Augmentation of labor" ], "offsets": [ [ 497, 518 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T37", "type": "Qualifier", "text": [ "tive p", "" ], "offsets": [ [ 532, 538 ], [ 549, 549 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T38", "type": "Qualifier", "text": [ "active phase" ], "offsets": [ [ 530, 542 ] ], "normalized": [] }, { "id": "NCT03140488_exc_T39", "type": "Scope", "text": [ "latent or active phase" ], "offsets": [ [ 520, 542 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03140488_exc_R1", "type": "Has_value", "arg1_id": "NCT03140488_exc_T2", "arg2_id": "NCT03140488_exc_T1", "normalized": [] }, { "id": "NCT03140488_exc_R2", "type": "Has_temporal", "arg1_id": "NCT03140488_exc_T2", "arg2_id": "NCT03140488_exc_T3", "normalized": [] }, { "id": "NCT03140488_exc_R3", "type": "Has_temporal", "arg1_id": "NCT03140488_exc_T5", "arg2_id": "NCT03140488_exc_T4", "normalized": [] }, { "id": "NCT03140488_exc_R4", "type": "Subsumes", "arg1_id": "NCT03140488_exc_T5", "arg2_id": "NCT03140488_exc_T9", "normalized": [] }, { "id": "NCT03140488_exc_R5", "type": "Has_value", "arg1_id": "NCT03140488_exc_T10", "arg2_id": "NCT03140488_exc_T11", "normalized": [] }, { "id": "NCT03140488_exc_R6", "type": "AND", "arg1_id": "NCT03140488_exc_T13", "arg2_id": "NCT03140488_exc_T14", "normalized": [] }, { "id": "NCT03140488_exc_R7", "type": "Has_temporal", "arg1_id": "NCT03140488_exc_T18", "arg2_id": "NCT03140488_exc_T17", "normalized": [] }, { "id": "NCT03140488_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03140488_exc_T18", "arg2_id": "NCT03140488_exc_T16", "normalized": [] }, { "id": "NCT03140488_exc_R9", "type": "Has_qualifier", "arg1_id": "NCT03140488_exc_T21", "arg2_id": "NCT03140488_exc_T20", "normalized": [] }, { "id": "NCT03140488_exc_R10", "type": "Has_temporal", "arg1_id": "NCT03140488_exc_T21", "arg2_id": "NCT03140488_exc_T19", "normalized": [] }, { "id": "NCT03140488_exc_R11", "type": "Has_negation", "arg1_id": "NCT03140488_exc_T28", "arg2_id": "NCT03140488_exc_T27", "normalized": [] }, { "id": "NCT03140488_exc_R12", "type": "Has_value", "arg1_id": "NCT03140488_exc_T25", "arg2_id": "NCT03140488_exc_T24", "normalized": [] }, { "id": "NCT03140488_exc_R13", "type": "Has_value", "arg1_id": "NCT03140488_exc_T28", "arg2_id": "NCT03140488_exc_T26", "normalized": [] }, { "id": "NCT03140488_exc_R14", "type": "Has_scope", "arg1_id": "NCT03140488_exc_T23", "arg2_id": "NCT03140488_exc_T30", "normalized": [] }, { "id": "NCT03140488_exc_R15", "type": "Has_scope", "arg1_id": "NCT03140488_exc_T32", "arg2_id": "NCT03140488_exc_T35", "normalized": [] }, { "id": "NCT03140488_exc_R16", "type": "Has_scope", "arg1_id": "NCT03140488_exc_T36", "arg2_id": "NCT03140488_exc_T39", "normalized": [] } ]

[ { "id": "NCT03140488_inc_text", "type": "inclusion", "text": [ "Singleton pregnancy = 37 weeks gestation\nPatient presented for induction of labor who is determined to be a candidate for oxytocin\nCephalic presentation\nReassuring fetal health assessment (no abnormal findings in fetal assessment, see below)\nMeeting one of the following BMI category:\n" ], "offsets": [ [ 0, 285 ] ] } ]

[ { "id": "NCT03140488_inc_T1", "type": "Condition", "text": [ "Singleton pregnancy" ], "offsets": [ [ 0, 19 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T2", "type": "Value", "text": [ "= 37 weeks" ], "offsets": [ [ 20, 30 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T3", "type": "Measurement", "text": [ "gestation" ], "offsets": [ [ 31, 40 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T4", "type": "Procedure", "text": [ "induction of labor" ], "offsets": [ [ 63, 81 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T5", "type": "Mood", "text": [ "presented for" ], "offsets": [ [ 49, 62 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T6", "type": "Condition", "text": [ "candidate for oxytocin" ], "offsets": [ [ 108, 130 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T7", "type": "Drug", "text": [ "oxytocin" ], "offsets": [ [ 122, 130 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T8", "type": "Observation", "text": [ "Cephalic presentation" ], "offsets": [ [ 131, 152 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T9", "type": "Value", "text": [ "Reassuring" ], "offsets": [ [ 153, 163 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T10", "type": "Measurement", "text": [ "fetal health assessment" ], "offsets": [ [ 164, 187 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T11", "type": "Negation", "text": [ "no" ], "offsets": [ [ 194, 196 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T12", "type": "Condition", "text": [ "abnormal findings" ], "offsets": [ [ 192, 209 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T13", "type": "Procedure", "text": [ "fetal assessment" ], "offsets": [ [ 213, 229 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T14", "type": "Scope", "text": [ "no abnormal findings in fetal assessment" ], "offsets": [ [ 189, 229 ] ], "normalized": [] }, { "id": "NCT03140488_inc_T15", "type": "Scope", "text": [ "Reassuring fetal health assessment" ], "offsets": [ [ 153, 187 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03140488_inc_R1", "type": "Has_value", "arg1_id": "NCT03140488_inc_T3", "arg2_id": "NCT03140488_inc_T2", "normalized": [] }, { "id": "NCT03140488_inc_R2", "type": "Has_mood", "arg1_id": "NCT03140488_inc_T4", "arg2_id": "NCT03140488_inc_T5", "normalized": [] }, { "id": "NCT03140488_inc_R4", "type": "Has_value", "arg1_id": "NCT03140488_inc_T10", "arg2_id": "NCT03140488_inc_T9", "normalized": [] }, { "id": "NCT03140488_inc_R5", "type": "Has_negation", "arg1_id": "NCT03140488_inc_T12", "arg2_id": "NCT03140488_inc_T11", "normalized": [] }, { "id": "NCT03140488_inc_R6", "type": "AND", "arg1_id": "NCT03140488_inc_T13", "arg2_id": "NCT03140488_inc_T12", "normalized": [] }, { "id": "NCT03140488_inc_R7", "type": "Subsumes", "arg1_id": "NCT03140488_inc_T15", "arg2_id": "NCT03140488_inc_T14", "normalized": [] } ]

[ { "id": "NCT03146390_exc_text", "type": "exclusion", "text": [ "Smoker or former smoker.\nPresence of dental prostheses.\nPresence of orthodontic devices.\nAntibiotic treatment or routine use of oral antiseptics in the previous 3 months.\nPresence of any systemic disease that could alter the production or composition of saliva.\n" ], "offsets": [ [ 0, 262 ] ] } ]

[ { "id": "NCT03146390_exc_T1", "type": "Condition", "text": [ "Smoker" ], "offsets": [ [ 0, 6 ] ], "normalized": [] }, { "id": "NCT03146390_exc_T2", "type": "Condition", "text": [ "former smoker" ], "offsets": [ [ 10, 23 ] ], "normalized": [] }, { "id": "NCT03146390_exc_T3", "type": "Device", "text": [ "dental prostheses" ], "offsets": [ [ 37, 54 ] ], "normalized": [] }, { "id": "NCT03146390_exc_T4", "type": "Device", "text": [ "orthodontic devices" ], "offsets": [ [ 68, 87 ] ], "normalized": [] }, { "id": "NCT03146390_exc_T5", "type": "Drug", "text": [ "Antibiotic" ], "offsets": [ [ 89, 99 ] ], "normalized": [] }, { "id": "NCT03146390_exc_T6", "type": "Multiplier", "text": [ "routine use" ], "offsets": [ [ 113, 124 ] ], "normalized": [] }, { "id": "NCT03146390_exc_T7", "type": "Drug", "text": [ "oral antiseptics" ], "offsets": [ [ 128, 144 ] ], "normalized": [] }, { "id": "NCT03146390_exc_T8", "type": "Temporal", "text": [ "in the previous 3 months" ], "offsets": [ [ 145, 169 ] ], "normalized": [] }, { "id": "NCT03146390_exc_T9", "type": "Condition", "text": [ "systemic disease" ], "offsets": [ [ 187, 203 ] ], "normalized": [] }, { "id": "NCT03146390_exc_T10", "type": "Qualifier", "text": [ "could alter the production or composition of saliva" ], "offsets": [ [ 209, 260 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03146390_exc_R1", "type": "Has_temporal", "arg1_id": "NCT03146390_exc_T7", "arg2_id": "NCT03146390_exc_T8", "normalized": [] }, { "id": "NCT03146390_exc_R2", "type": "Has_multiplier", "arg1_id": "NCT03146390_exc_T7", "arg2_id": "NCT03146390_exc_T6", "normalized": [] }, { "id": "NCT03146390_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03146390_exc_T9", "arg2_id": "NCT03146390_exc_T10", "normalized": [] } ]

[ { "id": "NCT03146390_inc_text", "type": "inclusion", "text": [ "Systemically healthy adults.\nMinimum of 24 permanent teeth.\nNo gingivitis (Community Periodontal Index score = 0).\nNo periodontitis (Community Periodontal Index score = 0).\nAbsence of untreated caries.\n" ], "offsets": [ [ 0, 202 ] ] } ]

[ { "id": "NCT03146390_inc_T1", "type": "Qualifier", "text": [ "Systemically" ], "offsets": [ [ 0, 12 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T2", "type": "Condition", "text": [ "healthy" ], "offsets": [ [ 13, 20 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T3", "type": "Person", "text": [ "adults" ], "offsets": [ [ 21, 27 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T4", "type": "Multiplier", "text": [ "Minimum of 24" ], "offsets": [ [ 29, 42 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T5", "type": "Observation", "text": [ "permanent teeth" ], "offsets": [ [ 43, 58 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T6", "type": "Negation", "text": [ "No" ], "offsets": [ [ 60, 62 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T7", "type": "Condition", "text": [ "gingivitis" ], "offsets": [ [ 63, 73 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T8", "type": "Measurement", "text": [ "Community Periodontal Index score" ], "offsets": [ [ 75, 108 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T9", "type": "Value", "text": [ "= 0" ], "offsets": [ [ 109, 112 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T10", "type": "Scope", "text": [ "No gingivitis" ], "offsets": [ [ 60, 73 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T11", "type": "Scope", "text": [ "Community Periodontal Index score = 0" ], "offsets": [ [ 75, 112 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T12", "type": "Negation", "text": [ "No" ], "offsets": [ [ 115, 117 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T13", "type": "Condition", "text": [ "periodontitis" ], "offsets": [ [ 118, 131 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T14", "type": "Measurement", "text": [ "Community Periodontal Index score" ], "offsets": [ [ 133, 166 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T15", "type": "Value", "text": [ "= 0" ], "offsets": [ [ 167, 170 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T16", "type": "Scope", "text": [ "Community Periodontal Index score = 0" ], "offsets": [ [ 133, 170 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T17", "type": "Scope", "text": [ "No periodontitis" ], "offsets": [ [ 115, 131 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T18", "type": "Qualifier", "text": [ "untreated" ], "offsets": [ [ 184, 193 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T19", "type": "Condition", "text": [ "caries" ], "offsets": [ [ 194, 200 ] ], "normalized": [] }, { "id": "NCT03146390_inc_T20", "type": "Negation", "text": [ "Absence" ], "offsets": [ [ 173, 180 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03146390_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03146390_inc_T2", "arg2_id": "NCT03146390_inc_T1", "normalized": [] }, { "id": "NCT03146390_inc_R2", "type": "Has_multiplier", "arg1_id": "NCT03146390_inc_T5", "arg2_id": "NCT03146390_inc_T4", "normalized": [] }, { "id": "NCT03146390_inc_R3", "type": "Has_value", "arg1_id": "NCT03146390_inc_T8", "arg2_id": "NCT03146390_inc_T9", "normalized": [] }, { "id": "NCT03146390_inc_R4", "type": "Has_negation", "arg1_id": "NCT03146390_inc_T7", "arg2_id": "NCT03146390_inc_T6", "normalized": [] }, { "id": "NCT03146390_inc_R5", "type": "Subsumes", "arg1_id": "NCT03146390_inc_T10", "arg2_id": "NCT03146390_inc_T11", "normalized": [] }, { "id": "NCT03146390_inc_R6", "type": "Has_negation", "arg1_id": "NCT03146390_inc_T13", "arg2_id": "NCT03146390_inc_T12", "normalized": [] }, { "id": "NCT03146390_inc_R7", "type": "Has_value", "arg1_id": "NCT03146390_inc_T14", "arg2_id": "NCT03146390_inc_T15", "normalized": [] }, { "id": "NCT03146390_inc_R8", "type": "Subsumes", "arg1_id": "NCT03146390_inc_T17", "arg2_id": "NCT03146390_inc_T16", "normalized": [] }, { "id": "NCT03146390_inc_R9", "type": "Has_qualifier", "arg1_id": "NCT03146390_inc_T19", "arg2_id": "NCT03146390_inc_T18", "normalized": [] }, { "id": "NCT03146390_inc_R10", "type": "Has_negation", "arg1_id": "NCT03146390_inc_T19", "arg2_id": "NCT03146390_inc_T20", "normalized": [] } ]

[ { "id": "NCT03147599_exc_text", "type": "exclusion", "text": [ "Upper urinary tract deterioration\nUncontrolled diabetes mellitus\nEvident local or pelvic recurrence\nAdjuvant chemotherapy\nChronic retention\nPouch stones\nUrethral stricture or urethro-ileal maldirection\nSensitivity to Mebeverine\nUntreated chronic constipation\nActive symptomatic urinary infection\n" ], "offsets": [ [ 0, 296 ] ] } ]

[ { "id": "NCT03147599_exc_T1", "type": "Condition", "text": [ "Upper urinary tract deterioration" ], "offsets": [ [ 0, 33 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T2", "type": "Condition", "text": [ "diabetes mellitus" ], "offsets": [ [ 47, 64 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T3", "type": "Qualifier", "text": [ "Uncontrolled" ], "offsets": [ [ 34, 46 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T4", "type": "Condition", "text": [ "pelvic recurrence" ], "offsets": [ [ 82, 99 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T5", "type": "Condition", "text": [ "cal o", "currence\nA" ], "offsets": [ [ 75, 80 ], [ 91, 101 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T6", "type": "Procedure", "text": [ "Adjuvant chemotherapy" ], "offsets": [ [ 100, 121 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T7", "type": "Condition", "text": [ "Chronic retention" ], "offsets": [ [ 122, 139 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T8", "type": "Condition", "text": [ "Pouch stones" ], "offsets": [ [ 140, 152 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T9", "type": "Condition", "text": [ "Urethral stricture" ], "offsets": [ [ 153, 171 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T10", "type": "Condition", "text": [ "urethro-ileal maldirection" ], "offsets": [ [ 175, 201 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T11", "type": "Drug", "text": [ "Mebeverine" ], "offsets": [ [ 217, 227 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T12", "type": "Condition", "text": [ "Sensitivity" ], "offsets": [ [ 202, 213 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T13", "type": "Qualifier", "text": [ "Untreated" ], "offsets": [ [ 228, 237 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T14", "type": "Condition", "text": [ "chronic constipation" ], "offsets": [ [ 238, 258 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T15", "type": "Qualifier", "text": [ "symptomatic" ], "offsets": [ [ 266, 277 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T16", "type": "Qualifier", "text": [ "Active" ], "offsets": [ [ 259, 265 ] ], "normalized": [] }, { "id": "NCT03147599_exc_T17", "type": "Condition", "text": [ "urinary infection" ], "offsets": [ [ 278, 295 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03147599_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03147599_exc_T2", "arg2_id": "NCT03147599_exc_T3", "normalized": [] }, { "id": "NCT03147599_exc_R2", "type": "AND", "arg1_id": "NCT03147599_exc_T12", "arg2_id": "NCT03147599_exc_T11", "normalized": [] }, { "id": "NCT03147599_exc_R3", "type": "Has_qualifier", "arg1_id": "NCT03147599_exc_T14", "arg2_id": "NCT03147599_exc_T13", "normalized": [] }, { "id": "NCT03147599_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03147599_exc_T17", "arg2_id": "NCT03147599_exc_T15", "normalized": [] } ]

[ { "id": "NCT03147599_inc_text", "type": "inclusion", "text": [ "Men 18 years or older\nONB within 1 year post-surgery.\n" ], "offsets": [ [ 0, 54 ] ] } ]

[ { "id": "NCT03147599_inc_T1", "type": "Person", "text": [ "Men" ], "offsets": [ [ 0, 3 ] ], "normalized": [] }, { "id": "NCT03147599_inc_T2", "type": "Value", "text": [ "18 years or older" ], "offsets": [ [ 4, 21 ] ], "normalized": [] }, { "id": "NCT03147599_inc_T3", "type": "Person", "text": [ "18 years or older" ], "offsets": [ [ 4, 21 ] ], "normalized": [] }, { "id": "NCT03147599_inc_T4", "type": "Condition", "text": [ "ONB" ], "offsets": [ [ 22, 25 ] ], "normalized": [] }, { "id": "NCT03147599_inc_T5", "type": "Temporal", "text": [ "within 1 year post-surgery" ], "offsets": [ [ 26, 52 ] ], "normalized": [] }, { "id": "NCT03147599_inc_T6", "type": "Procedure", "text": [ "surgery" ], "offsets": [ [ 45, 52 ] ], "normalized": [] }, { "id": "NCT03147599_inc_T7", "type": "Reference_point", "text": [ "surgery" ], "offsets": [ [ 45, 52 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03147599_inc_R1", "type": "Has_value", "arg1_id": "NCT03147599_inc_T3", "arg2_id": "NCT03147599_inc_T2", "normalized": [] }, { "id": "NCT03147599_inc_R2", "type": "Has_index", "arg1_id": "NCT03147599_inc_T5", "arg2_id": "NCT03147599_inc_T7", "normalized": [] }, { "id": "NCT03147599_inc_R3", "type": "AND", "arg1_id": "NCT03147599_inc_T7", "arg2_id": "NCT03147599_inc_T6", "normalized": [] } ]

[ { "id": "NCT03149887_exc_text", "type": "exclusion", "text": [ "Pregnancy, coagulopathy, allergy to bupivacaine, renal failure, hepatic insufficiency, and/or inappropriate candidate for usual therapy (specifically, if unable to receive the usual preoperative interscalene nerve block: preexisting nerve injury on side of surgery, refusal of nerve block, infection at site of nerve block).\n" ], "offsets": [ [ 0, 325 ] ] } ]

[ { "id": "NCT03149887_exc_T1", "type": "Condition", "text": [ "Pregnancy" ], "offsets": [ [ 0, 9 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T2", "type": "Condition", "text": [ "coagulopathy" ], "offsets": [ [ 11, 23 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T3", "type": "Condition", "text": [ "allergy" ], "offsets": [ [ 25, 32 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T4", "type": "Drug", "text": [ "bupivacaine" ], "offsets": [ [ 36, 47 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T5", "type": "Condition", "text": [ "renal failure" ], "offsets": [ [ 49, 62 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T6", "type": "Condition", "text": [ "hepatic insufficiency" ], "offsets": [ [ 64, 85 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T7", "type": "Condition", "text": [ "inappropriate candidate" ], "offsets": [ [ 94, 117 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T8", "type": "Procedure", "text": [ "usual therapy" ], "offsets": [ [ 122, 135 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T9", "type": "Mood", "text": [ "unable to receive" ], "offsets": [ [ 154, 171 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T10", "type": "Procedure", "text": [ "preoperative interscalene nerve block" ], "offsets": [ [ 182, 219 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T12", "type": "Temporal", "text": [ "preexisting" ], "offsets": [ [ 221, 232 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T13", "type": "Condition", "text": [ "nerve injury" ], "offsets": [ [ 233, 245 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T14", "type": "Qualifier", "text": [ "side of surgery" ], "offsets": [ [ 249, 264 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T15", "type": "Condition", "text": [ "refusal of nerve block" ], "offsets": [ [ 266, 288 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T16", "type": "Condition", "text": [ "infection" ], "offsets": [ [ 290, 299 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T17", "type": "Qualifier", "text": [ "site of nerve block" ], "offsets": [ [ 303, 322 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T18", "type": "Scope", "text": [ "preexisting nerve injury on side of surgery, refusal of nerve block, infection at site of nerve block" ], "offsets": [ [ 221, 322 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T11", "type": "Scope", "text": [ "unable to receive the usual preoperative interscalene nerve block" ], "offsets": [ [ 154, 219 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T19", "type": "Scope", "text": [ "inappropriate candidate for usual therapy" ], "offsets": [ [ 94, 135 ] ], "normalized": [] }, { "id": "NCT03149887_exc_T20", "type": "Scope", "text": [ "unable to receive the usual preoperative interscalene nerve block: preexisting nerve injury on side of surgery, refusal of nerve block, infection at site of nerve block" ], "offsets": [ [ 154, 322 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03149887_exc_R1", "type": "AND", "arg1_id": "NCT03149887_exc_T3", "arg2_id": "NCT03149887_exc_T4", "normalized": [] }, { "id": "NCT03149887_exc_R2", "type": "AND", "arg1_id": "NCT03149887_exc_T7", "arg2_id": "NCT03149887_exc_T8", "normalized": [] }, { "id": "NCT03149887_exc_R3", "type": "Has_mood", "arg1_id": "NCT03149887_exc_T10", "arg2_id": "NCT03149887_exc_T9", "normalized": [] }, { "id": "NCT03149887_exc_R4", "type": "Has_qualifier", "arg1_id": "NCT03149887_exc_T16", "arg2_id": "NCT03149887_exc_T17", "normalized": [] }, { "id": "NCT03149887_exc_R5", "type": "Has_qualifier", "arg1_id": "NCT03149887_exc_T13", "arg2_id": "NCT03149887_exc_T14", "normalized": [] }, { "id": "NCT03149887_exc_R6", "type": "Has_temporal", "arg1_id": "NCT03149887_exc_T13", "arg2_id": "NCT03149887_exc_T12", "normalized": [] }, { "id": "NCT03149887_exc_R7", "type": "Has_scope", "arg1_id": "NCT03149887_exc_T11", "arg2_id": "NCT03149887_exc_T18", "normalized": [] }, { "id": "NCT03149887_exc_R8", "type": "Subsumes", "arg1_id": "NCT03149887_exc_T19", "arg2_id": "NCT03149887_exc_T18", "normalized": [] } ]

[ { "id": "NCT03149887_inc_text", "type": "inclusion", "text": [ "Adult patients up to age 75 years, undergoing elective, ambulatory, arthroscopic rotator cuff repair.\n" ], "offsets": [ [ 0, 102 ] ] } ]

[ { "id": "NCT03149887_inc_T1", "type": "Person", "text": [ "Adult" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03149887_inc_T2", "type": "Person", "text": [ "age" ], "offsets": [ [ 21, 24 ] ], "normalized": [] }, { "id": "NCT03149887_inc_T3", "type": "Value", "text": [ "up to", "75 years" ], "offsets": [ [ 15, 20 ], [ 25, 33 ] ], "normalized": [] }, { "id": "NCT03149887_inc_T4", "type": "Qualifier", "text": [ "elective" ], "offsets": [ [ 46, 54 ] ], "normalized": [] }, { "id": "NCT03149887_inc_T5", "type": "Visit", "text": [ "ambulatory" ], "offsets": [ [ 56, 66 ] ], "normalized": [] }, { "id": "NCT03149887_inc_T6", "type": "Procedure", "text": [ "arthroscopic rotator cuff repair" ], "offsets": [ [ 68, 100 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03149887_inc_R1", "type": "AND", "arg1_id": "NCT03149887_inc_T6", "arg2_id": "NCT03149887_inc_T5", "normalized": [] }, { "id": "NCT03149887_inc_R2", "type": "Has_qualifier", "arg1_id": "NCT03149887_inc_T6", "arg2_id": "NCT03149887_inc_T4", "normalized": [] }, { "id": "NCT03149887_inc_R3", "type": "Has_value", "arg1_id": "NCT03149887_inc_T2", "arg2_id": "NCT03149887_inc_T3", "normalized": [] } ]

[ { "id": "NCT03151603_exc_text", "type": "exclusion", "text": [ "signs of complicated UTI (e. g. temperature > 38°C, loin tenderness)\nconditions that may lead to complicated infections (i.e. renal diseases, patients with urinary catheter)\npregnancy/ breastfeeding\ncurrent self-medication with UU preparations e.g. z.B. Cystinol®, Uvalysat®, Arctuvan®\nantibiotic use in the last 7 days\nprevious UTI in the past 2 weeks\nhistory of pyelonephritis\ncontraindications for trial drugs\nserious diseases\ninability to understand trial Information\ncurrent participation in another clinical trial or participation in another clinical trial within the last 4 weeks\n" ], "offsets": [ [ 0, 587 ] ] } ]

[ { "id": "NCT03151603_exc_T1", "type": "Condition", "text": [ "complicated UTI" ], "offsets": [ [ 9, 24 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T2", "type": "Condition", "text": [ "loin tenderness" ], "offsets": [ [ 52, 67 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T3", "type": "Measurement", "text": [ "temperature" ], "offsets": [ [ 32, 43 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T4", "type": "Value", "text": [ "> 38°C" ], "offsets": [ [ 44, 50 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T5", "type": "Scope", "text": [ "temperature > 38°C, loin tenderness" ], "offsets": [ [ 32, 67 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T6", "type": "Condition", "text": [ "conditions" ], "offsets": [ [ 69, 79 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T7", "type": "Condition", "text": [ "complicated infections" ], "offsets": [ [ 97, 119 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T8", "type": "Condition", "text": [ "renal diseases" ], "offsets": [ [ 126, 140 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T9", "type": "Device", "text": [ "urinary catheter" ], "offsets": [ [ 156, 172 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T10", "type": "Person", "text": [ "patients" ], "offsets": [ [ 142, 150 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T11", "type": "Scope", "text": [ "renal diseases, patients with urinary catheter" ], "offsets": [ [ 126, 172 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T13", "type": "Drug", "text": [ "UU preparations" ], "offsets": [ [ 228, 243 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T14", "type": "Drug", "text": [ "z.B. Cystinol®" ], "offsets": [ [ 249, 263 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T15", "type": "Drug", "text": [ "Uvalysat®" ], "offsets": [ [ 265, 274 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T16", "type": "Drug", "text": [ "Arctuvan®" ], "offsets": [ [ 276, 285 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T17", "type": "Scope", "text": [ "z.B. Cystinol®, Uvalysat®, Arctuvan®" ], "offsets": [ [ 249, 285 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T18", "type": "Qualifier", "text": [ "self-medication" ], "offsets": [ [ 207, 222 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T19", "type": "Drug", "text": [ "antibiotic" ], "offsets": [ [ 286, 296 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T20", "type": "Temporal", "text": [ "last 7 days" ], "offsets": [ [ 308, 319 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T21", "type": "Condition", "text": [ "UTI" ], "offsets": [ [ 329, 332 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T22", "type": "Temporal", "text": [ "past 2 weeks" ], "offsets": [ [ 340, 352 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T23", "type": "Condition", "text": [ "pyelonephritis" ], "offsets": [ [ 364, 378 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T24", "type": "Mood", "text": [ "contraindications for" ], "offsets": [ [ 379, 400 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T25", "type": "Drug", "text": [ "drugs" ], "offsets": [ [ 407, 412 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T26", "type": "Qualifier", "text": [ "trial" ], "offsets": [ [ 401, 406 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T27", "type": "Condition", "text": [ "diseases" ], "offsets": [ [ 421, 429 ] ], "normalized": [] }, { "id": "NCT03151603_exc_T28", "type": "Qualifier", "text": [ "serious" ], "offsets": [ [ 413, 420 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03151603_exc_R1", "type": "Has_value", "arg1_id": "NCT03151603_exc_T3", "arg2_id": "NCT03151603_exc_T4", "normalized": [] }, { "id": "NCT03151603_exc_R2", "type": "Subsumes", "arg1_id": "NCT03151603_exc_T1", "arg2_id": "NCT03151603_exc_T5", "normalized": [] }, { "id": "NCT03151603_exc_R3", "type": "AND", "arg1_id": "NCT03151603_exc_T10", "arg2_id": "NCT03151603_exc_T9", "normalized": [] }, { "id": "NCT03151603_exc_R4", "type": "Subsumes", "arg1_id": "NCT03151603_exc_T6", "arg2_id": "NCT03151603_exc_T11", "normalized": [] }, { "id": "NCT03151603_exc_R5", "type": "AND", "arg1_id": "NCT03151603_exc_T6", "arg2_id": "NCT03151603_exc_T7", "normalized": [] }, { "id": "NCT03151603_exc_R6", "type": "Subsumes", "arg1_id": "NCT03151603_exc_T13", "arg2_id": "NCT03151603_exc_T17", "normalized": [] }, { "id": "NCT03151603_exc_R7", "type": "Has_qualifier", "arg1_id": "NCT03151603_exc_T13", "arg2_id": "NCT03151603_exc_T18", "normalized": [] }, { "id": "NCT03151603_exc_R8", "type": "Has_temporal", "arg1_id": "NCT03151603_exc_T19", "arg2_id": "NCT03151603_exc_T20", "normalized": [] }, { "id": "NCT03151603_exc_R9", "type": "Has_temporal", "arg1_id": "NCT03151603_exc_T21", "arg2_id": "NCT03151603_exc_T22", "normalized": [] }, { "id": "NCT03151603_exc_R10", "type": "Has_qualifier", "arg1_id": "NCT03151603_exc_T25", "arg2_id": "NCT03151603_exc_T26", "normalized": [] }, { "id": "NCT03151603_exc_R11", "type": "Has_mood", "arg1_id": "NCT03151603_exc_T25", "arg2_id": "NCT03151603_exc_T24", "normalized": [] }, { "id": "NCT03151603_exc_R12", "type": "Has_qualifier", "arg1_id": "NCT03151603_exc_T27", "arg2_id": "NCT03151603_exc_T28", "normalized": [] } ]

[ { "id": "NCT03151603_inc_text", "type": "inclusion", "text": [ "Women (18-75 years) with suspected UTI\nat least two symptoms of UTI (dysuria, urgency of micturition, frequency, lower abdominal pain)\nWritten informed consent\n" ], "offsets": [ [ 0, 160 ] ] } ]

[ { "id": "NCT03151603_inc_T1", "type": "Person", "text": [ "Women" ], "offsets": [ [ 0, 5 ] ], "normalized": [] }, { "id": "NCT03151603_inc_T2", "type": "Person", "text": [ "years" ], "offsets": [ [ 13, 18 ] ], "normalized": [] }, { "id": "NCT03151603_inc_T3", "type": "Value", "text": [ "18-75" ], "offsets": [ [ 7, 12 ] ], "normalized": [] }, { "id": "NCT03151603_inc_T4", "type": "Condition", "text": [ "UTI" ], "offsets": [ [ 35, 38 ] ], "normalized": [] }, { "id": "NCT03151603_inc_T5", "type": "Qualifier", "text": [ "suspected" ], "offsets": [ [ 25, 34 ] ], "normalized": [] }, { "id": "NCT03151603_inc_T6", "type": "Scope", "text": [ "Women (18-75 years)" ], "offsets": [ [ 0, 19 ] ], "normalized": [] }, { "id": "NCT03151603_inc_T7", "type": "Condition", "text": [ "symptoms of UTI" ], "offsets": [ [ 52, 67 ] ], "normalized": [] }, { "id": "NCT03151603_inc_T8", "type": "Multiplier", "text": [ "at least two" ], "offsets": [ [ 39, 51 ] ], "normalized": [] }, { "id": "NCT03151603_inc_T9", "type": "Condition", "text": [ "dysuria" ], "offsets": [ [ 69, 76 ] ], "normalized": [] }, { "id": "NCT03151603_inc_T10", "type": "Condition", "text": [ "urgency of micturition" ], "offsets": [ [ 78, 100 ] ], "normalized": [] }, { "id": "NCT03151603_inc_T11", "type": "Condition", "text": [ "frequency" ], "offsets": [ [ 102, 111 ] ], "normalized": [] }, { "id": "NCT03151603_inc_T12", "type": "Condition", "text": [ "lower abdominal pain" ], "offsets": [ [ 113, 133 ] ], "normalized": [] }, { "id": "NCT03151603_inc_T13", "type": "Scope", "text": [ "dysuria, urgency of micturition, frequency, lower abdominal pain" ], "offsets": [ [ 69, 133 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03151603_inc_R1", "type": "Has_qualifier", "arg1_id": "NCT03151603_inc_T4", "arg2_id": "NCT03151603_inc_T5", "normalized": [] }, { "id": "NCT03151603_inc_R2", "type": "Has_value", "arg1_id": "NCT03151603_inc_T2", "arg2_id": "NCT03151603_inc_T3", "normalized": [] }, { "id": "NCT03151603_inc_R3", "type": "AND", "arg1_id": "NCT03151603_inc_T6", "arg2_id": "NCT03151603_inc_T4", "normalized": [] }, { "id": "NCT03151603_inc_R4", "type": "Has_multiplier", "arg1_id": "NCT03151603_inc_T7", "arg2_id": "NCT03151603_inc_T8", "normalized": [] }, { "id": "NCT03151603_inc_R5", "type": "Subsumes", "arg1_id": "NCT03151603_inc_T7", "arg2_id": "NCT03151603_inc_T13", "normalized": [] } ]

[ { "id": "NCT03154931_exc_text", "type": "exclusion", "text": [ "Suicidal patients and/or severe automutilation behavior and/or psychotic symptoms and/or lack of event memory. \n \n" ], "offsets": [ [ 0, 123 ] ] } ]

[ { "id": "NCT03154931_exc_T1", "type": "Condition", "text": [ "Suicidal" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03154931_exc_T2", "type": "Condition", "text": [ "automutilation behavior" ], "offsets": [ [ 32, 55 ] ], "normalized": [] }, { "id": "NCT03154931_exc_T3", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 25, 31 ] ], "normalized": [] }, { "id": "NCT03154931_exc_T4", "type": "Condition", "text": [ "psychotic symptoms" ], "offsets": [ [ 63, 81 ] ], "normalized": [] }, { "id": "NCT03154931_exc_T5", "type": "Condition", "text": [ "lack of event memory" ], "offsets": [ [ 89, 109 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03154931_exc_R1", "type": "Has_qualifier", "arg1_id": "NCT03154931_exc_T2", "arg2_id": "NCT03154931_exc_T3", "normalized": [] } ]

[ { "id": "NCT03154931_inc_text", "type": "inclusion", "text": [ "Clinical Administered PTSD Scale 5 Monthly version Criteria A and >30 points \n" ], "offsets": [ [ 0, 78 ] ] } ]

[ { "id": "NCT03154931_inc_T1", "type": "Measurement", "text": [ "Clinical Administered PTSD Scale" ], "offsets": [ [ 0, 32 ] ], "normalized": [] }, { "id": "NCT03154931_inc_T2", "type": "Value", "text": [ ">30 points" ], "offsets": [ [ 66, 76 ] ], "normalized": [] }, { "id": "NCT03154931_inc_T3", "type": "Value", "text": [ "Criteria A" ], "offsets": [ [ 51, 61 ] ], "normalized": [] } ]

[]

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[ { "id": "NCT03154931_inc_R1", "type": "Has_value", "arg1_id": "NCT03154931_inc_T1", "arg2_id": "NCT03154931_inc_T2", "normalized": [] }, { "id": "NCT03154931_inc_R2", "type": "Has_value", "arg1_id": "NCT03154931_inc_T1", "arg2_id": "NCT03154931_inc_T3", "normalized": [] } ]

[ { "id": "NCT03156855_exc_text", "type": "exclusion", "text": [ "NA\n" ], "offsets": [ [ 0, 3 ] ] } ]

[]

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[]

[ { "id": "NCT03156855_inc_text", "type": "inclusion", "text": [ "children and teenagers aged less than 20 years,\nhistory of gastrectomy,\ngastric malignancy, including adenocarcinoma and lymphoma,\nprevious allergic reaction to antibiotics (bismuth, amoxicillin, metronidazole, clarithromycin, tetracycline) and PPI (esomeprazole),\ncontraindication to treatment drugs,\npregnant or lactating women,\nsevere concurrent disease,\nconcomitant use of clopidogrel, or (9) Unwilling to accept random assignment of subjects\n" ], "offsets": [ [ 0, 447 ] ] } ]

[ { "id": "NCT03156855_inc_T1", "type": "Person", "text": [ "children" ], "offsets": [ [ 0, 8 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T2", "type": "Person", "text": [ "teenagers" ], "offsets": [ [ 13, 22 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T3", "type": "Person", "text": [ "aged" ], "offsets": [ [ 23, 27 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T4", "type": "Value", "text": [ "less than 20 years" ], "offsets": [ [ 28, 46 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T5", "type": "Observation", "text": [ "history" ], "offsets": [ [ 48, 55 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T6", "type": "Procedure", "text": [ "gastrectomy" ], "offsets": [ [ 59, 70 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T7", "type": "Condition", "text": [ "gastric malignancy" ], "offsets": [ [ 72, 90 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T8", "type": "Condition", "text": [ "adenocarcinoma" ], "offsets": [ [ 102, 116 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T9", "type": "Condition", "text": [ "lymphoma" ], "offsets": [ [ 121, 129 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T10", "type": "Scope", "text": [ "adenocarcinoma and lymphoma" ], "offsets": [ [ 102, 129 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T11", "type": "Drug", "text": [ "bismuth" ], "offsets": [ [ 174, 181 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T12", "type": "Drug", "text": [ "amoxicillin" ], "offsets": [ [ 183, 194 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T13", "type": "Drug", "text": [ "metronidazole" ], "offsets": [ [ 196, 209 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T14", "type": "Drug", "text": [ "clarithromycin" ], "offsets": [ [ 211, 225 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T15", "type": "Drug", "text": [ "tetracycline" ], "offsets": [ [ 227, 239 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T16", "type": "Drug", "text": [ "PPI" ], "offsets": [ [ 245, 248 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T17", "type": "Drug", "text": [ "esomeprazole" ], "offsets": [ [ 250, 262 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T18", "type": "Drug", "text": [ "antibiotics" ], "offsets": [ [ 161, 172 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T19", "type": "Scope", "text": [ "bismuth, amoxicillin, metronidazole, clarithromycin, tetracycline" ], "offsets": [ [ 174, 239 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T20", "type": "Temporal", "text": [ "previous" ], "offsets": [ [ 131, 139 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T21", "type": "Condition", "text": [ "allergic reaction" ], "offsets": [ [ 140, 157 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T22", "type": "Scope", "text": [ "antibiotics (bismuth, amoxicillin, metronidazole, clarithromycin, tetracycline) and PPI (esomeprazole)" ], "offsets": [ [ 161, 263 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T23", "type": "Condition", "text": [ "contraindication" ], "offsets": [ [ 265, 281 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T24", "type": "Drug", "text": [ "treatment drugs" ], "offsets": [ [ 285, 300 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T25", "type": "Condition", "text": [ "pregnant" ], "offsets": [ [ 302, 310 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T26", "type": "Condition", "text": [ "lactating" ], "offsets": [ [ 314, 323 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T27", "type": "Person", "text": [ "women" ], "offsets": [ [ 324, 329 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T28", "type": "Qualifier", "text": [ "severe" ], "offsets": [ [ 331, 337 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T29", "type": "Temporal", "text": [ "concurrent" ], "offsets": [ [ 338, 348 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T30", "type": "Condition", "text": [ "disease" ], "offsets": [ [ 349, 356 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T31", "type": "Temporal", "text": [ "concomitant" ], "offsets": [ [ 358, 369 ] ], "normalized": [] }, { "id": "NCT03156855_inc_T32", "type": "Drug", "text": [ "clopidogrel" ], "offsets": [ [ 377, 388 ] ], "normalized": [] } ]

[]

[]

[ { "id": "NCT03156855_inc_R1", "type": "Has_value", "arg1_id": "NCT03156855_inc_T3", "arg2_id": "NCT03156855_inc_T4", "normalized": [] }, { "id": "NCT03156855_inc_R2", "type": "Has_temporal", "arg1_id": "NCT03156855_inc_T6", "arg2_id": "NCT03156855_inc_T5", "normalized": [] }, { "id": "NCT03156855_inc_R3", "type": "Subsumes", "arg1_id": "NCT03156855_inc_T7", "arg2_id": "NCT03156855_inc_T10", "normalized": [] }, { "id": "NCT03156855_inc_R4", "type": "Subsumes", "arg1_id": "NCT03156855_inc_T16", "arg2_id": "NCT03156855_inc_T17", "normalized": [] }, { "id": "NCT03156855_inc_R5", "type": "Subsumes", "arg1_id": "NCT03156855_inc_T18", "arg2_id": "NCT03156855_inc_T19", "normalized": [] }, { "id": "NCT03156855_inc_R6", "type": "Has_scope", "arg1_id": "NCT03156855_inc_T21", "arg2_id": "NCT03156855_inc_T22", "normalized": [] }, { "id": "NCT03156855_inc_R7", "type": "Has_temporal", "arg1_id": "NCT03156855_inc_T21", "arg2_id": "NCT03156855_inc_T20", "normalized": [] }, { "id": "NCT03156855_inc_R8", "type": "AND", "arg1_id": "NCT03156855_inc_T23", "arg2_id": "NCT03156855_inc_T24", "normalized": [] }, { "id": "NCT03156855_inc_R9", "type": "Has_temporal", "arg1_id": "NCT03156855_inc_T30", "arg2_id": "NCT03156855_inc_T29", "normalized": [] }, { "id": "NCT03156855_inc_R10", "type": "Has_qualifier", "arg1_id": "NCT03156855_inc_T30", "arg2_id": "NCT03156855_inc_T28", "normalized": [] }, { "id": "NCT03156855_inc_R11", "type": "Has_temporal", "arg1_id": "NCT03156855_inc_T32", "arg2_id": "NCT03156855_inc_T31", "normalized": [] } ]