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Lantus Solostar (A-S Medication Solutions): FDA Package Insert, Page 6 Page 6: A-S Medication Solutions: LANTUS is indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus. LANTUS is a... Lantus Solostar (Page 6 of 8) 14.4 Additional Clinical Studies in Adults with Diabetes Type 1 and Type 2 Different Timing of LANTUS Administration in Diabetes Type 1 and Diabetes Type 2 The safety and efficacy of once daily LANTUS administered either at pre-breakfast, pre-dinner, or at bedtime were evaluated in a randomized, controlled clinical study in adult patients with type 1 diabetes (Study H, n=378). Patients were also treated with insulin lispro at mealtime. The average age was 41 years. All patients were White (100%) and 54% were male. The mean BMI was approximately 25.3 kg/m 2. The mean duration of diabetes was 17 years. LANTUS administered at pre-breakfast or at pre-dinner (both once daily) resulted in similar reductions in HbA1c compared to that with bedtime administration (see Table 12). In these patients, data are available from 8-point home glucose monitoring. The maximum mean blood glucose was observed just prior to LANTUS injection regardless of time of administration. In this study, 5% of patients in the LANTUS-breakfast group discontinued treatment because of lack of efficacy. No patients in the other two groups (pre-dinner, bedtime) discontinued for this reason. The safety and efficacy of once daily LANTUS administered pre-breakfast or at bedtime were also evaluated in a randomized, active-controlled clinical study (Study I, n=697) in patients with type 2 diabetes not adequately controlled on oral antidiabetic therapy. All patients in this study also received glimepiride 3 mg daily. The average age was 61 years. The majority of patients were White (97%) and 54% were male. The mean BMI was approximately 28.7 kg/m 2. The mean duration of diabetes was 10 years. LANTUS given before breakfast was at least as effective in lowering HbA1c as LANTUS given at bedtime or NPH insulin given at bedtime (see Table 12). Table 12: Study of Different Times of Once Daily LANTUS Dosing in Type 1 (Study H) and Type 2 (Study I) Diabetes Mellitus Treatment durationTreatment in combination with Study H24 weeksInsulin lispro Study I24 weeksGlimepiride LANTUSBefore Breakfast LANTUSBefore Dinner LANTUSBedtime LANTUSBefore Breakfast LANTUSBedtime NPHBedtime * Intent-to-treat † Not applicable Number of subjects treated * 112 124 128 234 226 227 HbA1c Baseline mean 7.6 7.5 7.6 9.1 9.1 9.1 Mean change from baseline -0.2 -0.1 0.0 -1.3 -1.0 -0.8 Basal insulin dose (Units) Baseline mean 22 23 21 19 20 19 Mean change from baseline 5 2 2 11 18 18 Total insulin dose (Units) – – – NA † NA † NA † Baseline mean 52 52 49 – – – Mean change from baseline 2 3 2 – – – Body weight (kg) Baseline mean 77.1 77.8 74.5 80.7 82 81 Mean change from baseline 0.7 0.1 0.4 3.9 3.7 2.9 Progression of Retinopathy Evaluation in Adults with Diabetes Type 1 and Diabetes Type 2 LANTUS was compared to NPH insulin in a 5-year randomized clinical study that evaluated the progression of retinopathy as assessed with fundus photography using a grading protocol derived from the Early Treatment Diabetic Retinopathy Scale (ETDRS). Patients had type 2 diabetes (mean age 55 years) with no (86%) or mild (14%) retinopathy at baseline. Mean baseline HbA1c was 8.4%. The primary outcome was progression by 3 or more steps on the ETDRS scale at study endpoint. Patients with prespecified postbaseline eye procedures (pan-retinal photocoagulation for proliferative or severe nonproliferative diabetic retinopathy, local photocoagulation for new vessels, and vitrectomy for diabetic retinopathy) were also considered as 3-step progressors regardless of actual change in ETDRS score from baseline. Retinopathy graders were blinded to treatment group assignment. The results for the primary endpoint are shown in Table 13 for both the per-protocol and intent-to-treat populations, and indicate similarity of LANTUS to NPH in the progression of diabetic retinopathy as assessed by this outcome. In this study, the numbers of retinal adverse events reported for LANTUS and NPH insulin treatment groups were similar for adult patients with type 1 and type 2 diabetes. Table 13: Number (%) of Patients with 3 or More Step Progression on ETDRS Scale at Endpoint LANTUS (%) NPH (%) Difference * , † (SE) 95% CI for difference * Difference = LANTUS – NPH † Using a generalized linear model (SAS GENMOD) with treatment and baseline HbA1c strata (cutoff 9.0%) as the classified independent variables, and with binomial distribution and identity link function Per-protocol 53/374 (14.2%) 57/363 (15.7%) -2.0% (2.6%) -7.0% to +3.1% Intent-to-Treat 63/502 (12.5%) 71/487 (14.6%) -2.1% (2.1%) -6.3% to +2.1% The ORIGIN Study of Major Cardiovascular Outcomes in Patients with Established CV Disease or CV Risk Factors The Outcome Reduction with Initial Glargine Intervention study (i.e., ORIGIN) was an open-label, randomized, 2-by-2, factorial design study. One intervention in ORIGIN compared the effect of LANTUS to standard care on major adverse cardiovascular (CV) outcomes in 12,537 adults ≥ 50 years of age with: Abnormal glucose levels (i.e., impaired fasting glucose [IFG] and/or impaired glucose tolerance [IGT]) or early type 2 diabetes mellitus and Established CV disease or CV risk factors at baseline. The first coprimary endpoint was the time to first occurrence of a major adverse CV event defined as the composite of CV death, nonfatal myocardial infarction, and nonfatal stroke. The second coprimary endpoint was the time to the first occurrence of CV death or nonfatal myocardial infarction or nonfatal stroke or revascularization procedure or hospitalization for heart failure. Patients were randomized to either LANTUS (N=6,264) titrated to a goal fasting plasma glucose of ≤95 mg/dL or to standard care (N=6,273). Anthropometric and disease characteristics were balanced at baseline. The mean age was 64 years and 8% of patients were 75 years of age or older. The majority of patients were male (65%). Fifty nine percent were Caucasian, 25% were Latin, 10% were Asian and 3% were Black. The median baseline BMI was 29 kg/m 2. Approximately 12% of patients had abnormal glucose levels (IGT and/or IFG) at baseline and 88% had type 2 diabetes. For patients with type 2 diabetes, 59% were treated with a single oral antidiabetic drug, 23% had known diabetes but were on no antidiabetic drug and 6% were newly diagnosed during the screening procedure. The mean HbA1c (SD) at baseline was 6.5% (1.0). Fifty-nine percent of the patients had had a prior CV event and 39% had documented coronary artery disease or other CV risk factors. Vital status was available for 99.9% and 99.8% of patients randomized to LANTUS and standard care respectively at end of study. The median duration of follow-up was 6.2 years (range: 8 days to 7.9 years). The mean HbA1c (SD) at the end of the study was 6.5% (1.1) and 6.8% (1.2) in the LANTUS and standard care group respectively. The median dose of LANTUS at end of study was 0.45 U/kg. Eighty-one percent of patients randomized to LANTUS were using LANTUS at end of the study. The mean change in body weight from baseline to the last treatment visit was 2.2 kg greater in the LANTUS group than in the standard care group. Overall, the incidence of major adverse CV outcomes was similar between groups (seeTable 14). All-cause mortality was also similar between groups. Table 14: Cardiovascular Outcomes in ORIGIN in Patients with Established CV Disease or CV Risk Factors – Time to First Event Analyses LANTUSN=6,264 Standard CareN=6,273 LANTUS vs Standard Care n(Events per 100 PY) n(Events per 100 PY) Hazard Ratio (95% CI) Coprimary endpoints CV death, nonfatal myocardial infarction, or nonfatal stroke 1041(2.9) 1013(2.9) 1.02 (0.94, 1.11) CV death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure or revascularization procedure 1792(5.5) 1727(5.3) 1.04 (0.97, 1.11) Components of coprimary endpoints CV death 580 576 1.00 (0.89, 1.13) Myocardial Infarction (fatal or nonfatal) 336 326 1.03 (0.88, 1.19) Stroke (fatal or nonfatal) 331 319 1.03 (0.89, 1.21) Revascularizations 908 860 1.06 (0.96, 1.16) Hospitalization for heart failure 310 343 0.90 (0.77, 1.05) In the ORIGIN study, the overall incidence of cancer (all types combined) or death from cancer (Table 15) was similar between treatment groups. Table 15: Cancer Outcomes in ORIGIN – Time to First Event Analyses LANTUSN=6,264 Standard CareN=6.273 LANTUS vs Standard Care n(Events per 100 PY) n(Events per 100 PY) Hazard Ratio (95% CI) Cancer endpoints Any cancer event (new or recurrent) 559(1.56) 561(1.56) 0.99 (0.88, 1.11) New cancer events 524(1.46) 535(1.49) 0.96 (0.85, 1.09) Death due to Cancer 189(0.51) 201(0.54) 0.94 (0.77, 1.15)
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(PDF) Nutritional status of children in India: Household socio-economic condition as the contextual determinant PDF | Despite recent achievement in economic progress in India, the fruit of development has failed to secure a better nutritional status among all... | Find, read and cite all the research you need on ResearchGate Nutritional status of children in India: Household socio-economic condition as the contextual determinant August 2010 International Journal for Equity in Health 9(1):19 DOI: 10.1186/1475-9276-9-19 License CC BY 2.0 Authors: Md. Hafizur Rahman Abstract and Figures Despite recent achievement in economic progress in India, the fruit of development has failed to secure a better nutritional status among all children of the country. Growing evidence suggest there exists a socio-economic gradient of childhood malnutrition in India. The present paper is an attempt to measure the extent of socio-economic inequality in chronic childhood malnutrition across major states of India and to realize the role of household socio-economic status (SES) as the contextual determinant of nutritional status of children. Using National Family Health Survey-3 data, an attempt is made to estimate socio-economic inequality in childhood stunting at the state level through Concentration Index (CI). Multi-level models; random-coefficient and random-slope are employed to study the impact of SES on long-term nutritional status among children, keeping in view the hierarchical nature of data. Across the states, a disproportionate burden of stunting is observed among the children from poor SES, more so in urban areas. The state having lower prevalence of chronic childhood malnutrition shows much higher burden among the poor. Though a negative correlation (r = -0.603, p < .001) is established between Net State Domestic Product (NSDP) and CI values for stunting; the development indicator is not always linearly correlated with intra-state inequality in malnutrition prevalence. Results from multi-level models however show children from highest SES quintile posses 50 percent better nutritional status than those from the poorest quintile. In spite of the declining trend of chronic childhood malnutrition in India, the concerns remain for its disproportionate burden on the poor. The socio-economic gradient of long-term nutritional status among children needs special focus, more so in the states where chronic malnutrition among children apparently demonstrates a lower prevalence. The paper calls for state specific policies which are designed and implemented on a priority basis, keeping in view the nature of inequality in childhood malnutrition in the country and its differential characteristics across the states. Prevalence of Malnutrition among children (0-59 months) across fifteen major states of India (NFHS-3) … Trend in Malnutrition in India among Children (0-35 months) … Scatter plot showing relationship between NSDP and CI for Stunting, across the states. … Conceptual Framework … Trend in Malnutrition in India among Children (0-35 months) … Figures - uploaded by Nutritional status of children in India: household socio-economic condition as the contextual determinant Barun Kanjilal 1 , Papiya Guha Mazumdar 2* , Moumita Mukherjee 2 , M Hafizur Rahman 3 Abstract Background: Despite recent achievement in economic progress in India, the fruit of development has failed to secure a better nutritional status among all children of the country. Growing evidence suggest there exis ts a socio- economic gradient of childhood malnutrition in India. The present paper is an attempt to measure the extent of socio-economic inequality in chronic childhood malnutrition across major states of India and to realize the role of household socio-economic status (SES) as the contextual determinant of nutritional status of children. Methods: Using National Family Health Survey-3 dat a, an attempt is made to estimate socio-economic inequality in childhood stunting at the state level throug h Concentration Index (CI). Multi-level models; random-coefficient and random-slope are employed to study the impact of SES on long-term nutrit ional status among children, keeping in view the hierarchical nature of data. Main findings: Across the states, a disproportionate burden of stunting is observed among the children from poor SES, more so in urban areas. The state having lower prevalence of chronic childhoo d malnutrition shows much higher burden among the poor. Though a negative correlation (r = -0.603, p < .001) is establ ished between Net State Domestic Product (NSDP) and CI values for stunting; the development indicator is no t always linearly correlated with intra-state inequality in malnutrition prevale nce. Results from multi-level models however show children from highest SES quintile posses 50 percent better nutritional status than those from the poorest quintile. Conclusion: In spite of the declining trend of chronic childhood malnutrition in India, the concerns remain for its disproportionate burden on the poor. The socio-economic gradi ent of long-term nutritional status among children needs special focus, more so in the states where chronic malnutrition among children apparently demons trates a lower prevalence. The paper calls for state specific policies which are designed and implemented on a priority basis, keeping in view the nature of inequality in childhood malnutrition in the country and its differential characteristics across the states. Introduction Despite recent achievement in economic progress in India [1], the frui t of development has failed to secu re a better nutritional stat us of children in the country [2-5]. India presents a typical scen ario of South-Asia, fitting the adage of ‘ Asian Enigma ’ [6]; where progress in child- hood malnutrit ion seems to have sunken into an appa r- ent undernutrition trap, lagging far behind the other Asian countries characterized by similar levels of eco- nomic development [7-10]. Exhibiting a sluggish declining trend over the past decade and a half, the recent estimate from the National Family Health Survey -3 (NFHS-3)- the unique source for tracking the status of ch ild malnutrition in India [11]- indicates about 46 percent of the children under 5 years of age are moderately to severely underweight (thin for age), 38 percent ar e moderately to severely stunted (short for age), and approximately 19 percent are moderatel y to severely wasted (th in for height) [12]. The decline in prevalence however becomes unimpres- sive with the average levels marked by wide inequality * Correspondence: [email protected] 2 Future Health Systems India, Institue of Health Management Research, Kolkata, India Full list of author information is available at the end of the article Kanjilal et al . International Journal for Equity in Health 2010, 9 :19 http://www.equityhealthj.com/content/9/1/19 © 2010 Kanjila l et al; licensee BioMed Ce ntral Ltd. This is an Open Ac cess article distribu ted under the terms of the Cr eative Commons Attribution L icense (http://creati vecommons.org/lice nses/by/2.0), which perm its unrestricted use, di stribution, and repro duction in any medium, p rovided the original wor k is properly cited. in childhood malnutrition across the states and various socio-economic groups [2,3,13,14]. Growing evidence suggests [13] that in India the gap in prevalence of underweight children among the rich and the poor households is inc reasing over the years with wide re gio- nal differentials. From this specific context, the paper is an attempt to study the specific interplay between household socio-economic conditions and the nutri- tional status for In dian children (particular in respe ct to stunting, whi ch is an indicator for long-t erm nutritional status), considering controls for various other estab- lished predi ctors of the chronic child m alnutrition lying at individual, maternal, household and community characteristics. Socio-economic inequality in childhood malnutrition: Contextualizing the extent in India Socio-economic differences in morbidity and mortality rates across the wo rld have received its due attent ion in the recent years [15-17 ]. Such differentials in health sta- tus in-fact ar e found pervasive across na tions cross-cut- ting stages of development [18-29]. Studies have identified poverty as the chief determinant of malnutri- tion in develop ing countries that perpet uates into inter- generational transfer of poor nutritional status among children and prevents social improvement and equity [30,31]. Nut ritional status of und er-five children in par - ticular is often co nsidered as one of the most important indicator of a household ’ s living standard and also an important determi nant of child survival [32]. The deter- ministic studies in India while exploring the impact of covariates o n the degree of childhood ma lnutrition sug- gests an important nexus shared with household socio- economic status [2,25,33-41]. The two-way causality of poverty and under nutrition seems to pose a ver y signif- icant pretext for malnutrition in India like other devel- oping nations, where poverty and economic insecurity, coupled by constrained access to economic resources permeate malnourishment am ong the children [42-46]. Thus, economi c inequality constitutes t he focal point of discussion while studying malnut rition and deserves sui- table analytical treatment to examine its interplay with other dimensions of malnutrition and to prioritize appropriate programme intervention. Such attempt to the best of our knowledge is still awaited, using recent nationwide survey data in India. In this backdrop, the p aper attempts to shed lights on two specific objectives: 1) to find out the extent of socio-economic inequality in chronic childhood malnu- trition, across the major states of India, separated for urban and rural locations, and 2) to understand the con- ditional impact of househol d socio-economic condition on nutritional status of children per se, controlling for various other important cov ariates. The conceptual framework (F igure 1) of the study is based o n review of existing literature on the topic and adapts from various existing framework on determinants of childhood mal- nutrition in general [47], adding a special emphasis on household soci o-economic status as the key exp lanatory variable. Methodology Data The paper uses the National Family Health Survey (NFHS) 3rd round data (2005-06) for study and analysis. Similar to NFHS-1 and NFHS-2, NFHS-3 was designed to provide estimates of important maternal and child health indicators including nutritional status for young children (under five years for NFHS-3), following stan- dard anthropometric components. The survey was con- ducted following stratified s ampling technique, details on the sampling procedure can be found at IIPS, 2007 [12]. Of the total 43,737 children for whom NFHS-3 provides height-for-age z-score (HAZ ), a subset of 24,896 child ren was considered; th ose were alive, hailed from fifteen major states and had the HAZ score within the range of -5 to +5 standard deviation from the WHO-NCHS reference population. We have also used secondary data from Handbook of Indian Economy 2004-05 [48], for the statistics on per capita Net State Domestic Product (NSDP), for the fif- teen major states. Methods used The study uses two analytical methods for studying the objectives. The first objective is catered through the measurement of co ncentration index and underst anding its linkage with the state level indicator of economic development. While for study ing the second objective, multi-level regression model have been employed. Further details on methodology are presented below. Concentration Index The widely used standard tool that examines the magni- tude of socio-economic inequality in any health out- come, i.e. Concentration Index (CI) [49] is employed to study the extent of inequity in chronic child malnutri- tion across the states of India. The tool has been univer- s a l l yu s e db yt h ee c o n o m i s t st om e a s u r et h ed e g r e eo f inequality in various health system indicators, such as health outcome, health care utilization and financing. The value of CI ranges between -1 to +1, hence, if there is no socio-ec onomic differential th e value returns zero. A negative value implies that the relevant health variable is concentrated among the poor or disadvantaged people while the opposite is true for its positive values, when poorest are assigned the lowest value of the wealth- index. A zero CI implies a s tate of horizontal equity Kanjilal et al . International Journal for Equity in Health 2010, 9 :19 http://www.equityhealthj.com/content/9/1/19 Page 2 of 13 which is defined as equal treatm ent for equal needs (For further readings on application of CI in malnutrition refer to Wagstaff & Watanab e 2000) [50]. CI values cal- culated for stunting help us fi nd the possible concentra- tion among rich and poor children below five years of age during NFHS-3. Multi-level regression Due to the stratified nature of data in NFHS [12], the children are naturally nested into mothers, mothers are nested into households, hou seholds are into Primary Sampling Units (PSUs) and PSUs into states. Hence keeping in view this hierarchically clustered nature, the paper uses multi-level regr ession model to estimate parameter for nutritional status among children to avoid the likely under-estimatio n of parameters from a single level model [51]. Since here siblings are expected to share certain common char acteristics of the mother and the household (mother ’ s education and household eco- nomic status for e.g.) and children from a particular community or village have in common community level factors such as availability of health facilities and out- comes, it can be reasonably asserted that unobserved heterogeneity in the outcome variable is also correlated at the cluster levels [52-54]. This amounts to an estima- tion problem employing conve ntional OLS estimators, which gives efficient estimates only when the commu- nity level covariates and the household level covariates are uncorrelated with the individual and maternal effects covariates. Researchers have ad opted fixed effects models to esti- mate nutrition models and control for unobservable variables at the cluster level, which leads to the diffi- culty that if the fixed effect is differenced away, then the effect of those variables that do not vary in a cluster will be lost in the estimation process [54]. Allowing the contextual effects in our analysis of the impact of household socio-economic status on child undernutri- tion, we adopt an al ternative approach of using multi le- vel models. Individual Characteristics of Child • Age • Sex • Birth Order • Size at birth • Child feeding practice Mother Specific • Education • Occupation • Nutritional Status (BMI) • Anemia status • Healthcare related autonomy Household Characteristics Household Specific • Ethnicity • Socio-economic status Health Service Uptake • Status of Institutional Delivery • Status of immunization Place of Residence • Urban • Rural State Distant Intermediate Proximate Chronic Malnutrition among Children Figure 1 Conceptual Framework Kanjilal et al . International Journal for Equity in Health 2010, 9 :19 Broadly, we test the two types of multilevel models following the practice in co ntemporary literature; the variance comp onents (or random interce pt) models and the random coefficients (or random slopes) models. As in above, STATA routines for hie rarchical linear models using maximum likelihood estimators for linear mixed models were used for both model forms. The variance-components model correct for the problem of correlated observations in a cluster, by introducing a random effect at each cluster. In other words, subjects within the same cluster are allowed to have a shared random intercept. We consider two clus- ters, i.e., community and household, since in most of the cases NFHS provides information on children of one mother chosen from a particular household. Thus, we have, zx ij ij i ij =′ + +     where z ij is the HAZ score for the child(re n) from the j th household in the i th community. b is a vector of regression coefficients corresponding to the effects of fixed covariates x ij , which are the observed characteris- tics of the child, the household and the community. Where, ‘ i ’ is a random community effect denoting the deviation of community i ’ s mean z-score from the grand mean, ‘ j ’ is a random household effect that represents deviation of household ij ’ s mean z-score from the i th community mean. The error terms δ i and μ ij are assumed to be normal ly distributed with zero mean and variances s 2 c and s 2, h respectively. As per our argu- ments above, these terms are non-zero and estimated by variance components models. To the extent that the greater homogeneity of within-cluster observations is not explained by the observed covariates, s 2 c ,a n d s 2, h will be larger [55]. To evaluate the appropriateness of the multilevel models, we test whether the variances of the random part are different from zero over households and com- munities. The resulting estimates from the models can be used to assess the Intra Class Correlation (ICC) i.e., the extent to which child undernutrition is correlated within households and communities, before and after we have accounted for the obs erved effects of covariates . A significantly different ICC from zero suggests appropriateness of random effect models [54]. The ICC coefficient describes the pro portion of variation that is attributable to the higher level source of variation. The correlations between the anthropometric outcomes of children in the same commu nity and in the same family are respectively:      cc c h 22 2 =+ /( ) Following this, the total variability in the individual HAZ scores can be divided into its two components; variance in children ’ s nutritional status among house- holds within communities, and variance among commu- nities. By including covariates at each le vel, the variance components models allow to examine the extent to which observed differences in the anthropometric scores are attributable to factors operating at each level. Thus, the variance components model described above intro- duces a random intercept at each level or cluster assum- ing a constant effect of each of the covariates (on the If additionally, we consider the effect of certain covari- ates to vary across the clusters (for e.g, differential impact of household socio-economic status or mother ’ s education across households and/or communities), we need to introduce a random effect for the slopes as well, leading to a random coefficients model. Under these assumptions, the covariance of the disturbances, and therefore the total variance at each level depend on the values of the predictors [55]. As mentioned earlier, a subse t of 24,896 children have been considered for the analysis from the hierarchically clustered NFHS-3 da taset. Hence, our multilevel model s are based on observations on 24,896 children from 18,078 households distributed in 2,440 communities/ clusters (PS Us). Inclusion of separ ate levels for children and mothers were considered not necessary since these were almost unitary to the number of households. The analysis is presented in the form of five models, apart from the conventional OLS model wit hout consid- ering the cluster random effects, primaril y as a compari- son: Model_Null is the null model, where the HAZ z scores is the dependant variable with no covariates and richest household asset quintile, other covariates are introduced in a phased manner. Such as, Model_Kids introduces ch ild specific predictors (be ing purely indivi- dual attributes); Model_Moms introduces the mother- specific cov ariates. Model_Full is t he full model with all the model covariates at respective levels. These models are three-level random intercept models with the two clusters: community, and households. In Model_Ran- dom_Slope, we introduce a random coefficient for socio-economic status at the household level. We settled for the random coefficient in the form of wealth quintile dummies. The covariates included as controls in our analytical models, with the primary aim of isolating the effect of income or socioeconomic status (SES) on chronic child undernutriti on are described below. In the multilevel framework most of these variables can be classified as individual-specific, household-specific or community-specific covariates. Kanjilal et al . International Journal for Equity in Health 2010, 9 :19 Variables in the regression model As mentioned earlier, the paper uses height for age (stunting) as the key outcome var iable, which is an indi- cator of chronic nutritional status capable of reflecting long-term deprivation of food [56] following the estab- lished practice o f anthropometric measures of malnu tri- tion. The measure is expressed in the form of z-scores standard deviation (SD) from the median of the 2006 WHO International Reference Populati on. This continu- ous standard deviation of HAZ score is capable of pro- viding expected change in the value of the response variable due to one unit change in the regressors regard- less of whether a child is stunted or not [57]. Hence, the present approach differs from the usual practice of employing a dichotomous variable on probability of a child being chronically malnourished (0 = otherwise, 1 = stunted). Since here the attempt is not to model prob- ability of stunting, but instead using a deterministic model the paper attempts to find out the influencing role of household asset o n childhood nutrition in fifteen major states of India. Explanatory variables Asset quintile as the proxy for household socio-economic status Following the standard approach of assessing economic status of the household [28], the paper uses household asset index provided by the NFHS-3. The survey pro- vides the household wealth index based on thirty-three household characteristics and ownership of household assets using a Principal Component analysis (for details on the methodology refer to IIPS 2007) [12]. In the paper we divided the household index into quintiles based on the asset scores adj usted by sample weights. Separate quintiles were developed for rural and urban areas of each state by using state-specific sample weights, to avoid questions on comparability [28]. Other explanatory variables used as controls Apart from the above mentioned asset index, other determinants of childhood malnutrition are chosen based on approaches in literature and presented in the conceptual framework (Figure 1) of the study [47]. We consider certain indi vidual characteristics of child as the proximate covar iate of chronic malnutrit ion. These pre- disposing factors include child ’ s characteristics similar to other studies, such as, child ’ s age in months, quadratic form of age to elimi nate the effect on z-score [38 ] since there exists non-linearity between age and HAZ, sex of the child, birth order, size of child at birth (as a proxy of birth weight) [57], incidence of recent illness, com- plete doses of immunization and recommended feeding practice; denoted by exclusive breast feeding for infants below six months of age, introduction of nutritional supplements along with or without breastmilk after six months. In view of information provided by NFHS on child feeding, we considered a child is introduced to supplementary food, where ver the child was reported having given any food-stuff irrespective of its breast feeding status, a day preceding the survey date. The controls on mother ’ s characteristics includes; years of in terms of education, body mass index (BMI), mothers status of anemia, autonomy for seeking medical help for self [58,59] and place of birth for the child of interest. On the household level, except for asset quin- tile, controls was incl uded for household ethnicity, since a large number of earlier st udies found a significant linkage between scheduled tribe/scheduled caste house- holds and childhood undernutrition [2,14]. Community characteristic is regarded as the distant covariate of child malnutrition in t he model and include rural-urban Figure 2 Trend in Malnutrition in India among Children (0-35 months) Kanjilal et al . International Journal for Equity in Health 2010, 9 :19 http://www.equityhealthj.com/content/9/1/19 place of residence and state. Keeping in mind the large scale variation in childhood mortality and morbidity, the states are consider ed for each of the models as contro ls, or as fixed effects in multilevel models. Results Extent of socio-economic inequity in childhood stunting As mentioned earlier, the successive waves of NFHS in India indicates a declining trend in the prevalence of child malnutrition among children aged below three years (Figure 2). Except for wasting, across the two different established anthropometric measures of malnutrition; stunting and underweight, a consistent decline is evident during 1992-2005 period (Figure 2). Overall, NFHS-3 reveals a different ial scenario of chil d malnutrition acros s the fif- teen major states of India (Table 1). To describe further, the state of Kerala showed the low- est prevalence of stunting among children (25 percent) across all the major states, where the rural-urban differ- ential is virt ually nonexistent. Whereas the opposit e side of the spectrum, more than half the children below five years were stunted in Uttar P radesh (57 percen t), Bihar (56 percent), Gujarat (52 percent) and Madhya Pradesh (50 percent) (Table 1). The rural-urban differentials are also considerably high in these states, along with West Bengal; which showed the highest (19 percent) d ifferen- tial between rural-urba n prevalence of child malnutrition which is unfavorable for rural areas, during NFHS-3. Overall, all the three indicators of malnourishment are found highly correlated with each other and hence it was worthwhile to explore their association with the incidence of poverty in the s tates, following the estab- lished line of argument. It c an be said that the optimal growth of the ch ildren (having standard height for thei r age and weight for their height) have been strongly associated with economic status of the population. Table 1 Prevalence of Malnutrition among children (0-59 months) across fifteen major states of India (NFHS-3) States/Country Underweight Stunting Wasting Rural Urban Total Rural Urban Total Rural Urban Total Haryana 41.3 34.6 39.6 48.1 38.3 45.7 19.7 17.3 19.1 Punjab 26.8 21.4 24.9 37.5 35.1 36.7 9.2 9.2 9.2 Rajasthan 42.5 30.1 39.9 46.3 33.9 43.7 20.3 20.8 20.4 Uttar Pradesh 44.1 34.8 42.4 58.4 50.1 56.8 15.2 12.9 14.8 Bihar 57 47.8 55.9 56.5 48.4 55.6 27.4 25.2 27.1 Orissa 42.3 29.7 40.7 46.5 34.9 45.0 20.5 13.4 19.5 West Bengal 42.2 24.7 38.7 48.4 29.3 44.6 17.8 13.5 16.9 Assam 37.7 26.1 36.4 47.8 35.6 46.5 13.6 14.2 13.7 Gujarat 47.9 39.2 44.6 54.8 46.6 51.7 19.9 16.7 18.7 Andhra Pradesh 34.8 28 32.5 45.8 36.7 42.7 13 10.7 12.2 Karnataka 41.1 30.7 37.6 47.7 36 43.7 18.2 16.5 17.6 Kerala 26.4 15.4 22.9 25.6 22.2 24.5 18.2 10.9 15.9 Tamilnadu 32.1 27.1 29.8 31.3 30.5 30.9 22.6 21.6 22.2 All 15 states 44.1 32.2 41.1 49.7 39.2 47.04 19.9 16.6 19.04 Source: Authors ’ Calculation from NFHS 3 unit data Table 2 Concentration Index Values for Stunting across States and Urban-Rural Locations, India, NFHS-3 States/Country Concentration Index (Stunting) Rural Urban Total Haryana -0.118** -0.257** -0.151** Punjab -0.211** -0.259** -0.212** Rajasthan -0.069** -0.182** -0.106** Madhya Pradesh -0.032 -0.133** -0.063** Bihar -0.082** -0.131** -0.094** Orissa -0.169** -0.267** -0.183** West Bengal -0.112** -0.3** -0.168** Assam -0.101** -0.253** -0.116** Gujarat -0.087** -0.132** -0.115** Maharashtra -0.12** -0.167** -0.146** Andhra Pradesh -0.104** -0.134** -0.14** Karnataka -0.076** -0.185** -0.127** Kerala -0.204** -0.061 -0.165** Tamil Nadu -0.075 -0.196** -0.131** All 15 states -0.092** -0.177** -0.121** ALL INDIA -0.098** -0.169** -0.126** Source: Authors ’ Calculation from NFHS 3 unit data Significant at ***p < 0.01, ** p < 0.05, and * p < 0.10. The CI values for chronic malnutrition in respect to fifteen major st ates and at the country level cons istently return negative values, reflecting a heavy burden of malnutrition among the poor in India (Table 2). The above table (Table 2) confirms the fact that across children from poorer households share the higher bur- den of sub-optimal gr owth due to undernourishment. It needs speci al mention that chroni c malnutrition among children is more concentrat ed among urban poor com- paring their count erpart living in rural areas. This trend is consistent across all thirt een states, except for Bihar and Kerala; wh ere concentration of stun ting is observed higher among poor children from rural areas. It is also seen in a similar vein that aggregate eco- nomic status of a population is associated with child nutritional status. CI values for stunting and Net State Domestic Product (NSDP; considered as the indicator for economic devel opment for the aggregate level of the state) share an inverse association (Figure 3), common for most of the states. Overall, the negative corre lation established between CI values for stunting and NSDP per capita stands at r = -0.603 (p < .001). The scatter plot of NSDP per capita and CI values for stunted children across the states (Figure 3) emerges few specific patterns. The states like, Bihar, Uttar Pradesh, Madhya Pradesh and Rajasthan exhibit a typical situation where per capita 0.134 (0.074) Kanjilal et al . International Journal for Equity in Health 2010, 9 :19 http://www.equityhealthj.com/content/9/1/19 Page 8 of 13 per-capita NSDP as compared to the national average, the state exhibits a noticeably higher burden of chronic malnourishment among the poor. Role of household socio-economic conditions determining long-term nutritional status among children The results shows (Table 3), significant association between househ old asset quintiles and nutri tional status of children. Given the form of the dependent variable in the sub- sequent models a higher coefficient indicates better nutritional status among children from better off socio- economic status quintiles (SES). It shows (Table 3) nearly 50 percent better nutritional status (0.31 - (-0.18)) among children from richest SES quintiles, com- pared to ones those from the poorest quintile. The variance component mo dels (i.e., Model_kids, Model_moms and Model_full) and the random slope model (Table 3) also support such finding. By introdu- cing covariates at each level, the variance component models allow to examine the extent to which observed differences in the HAZ scores are attributed to the fac- tors operating at each level. With the introduction of child ’ s individual characteristics in the Mode l_kids along with the state level fixed effect, the impact of richest & poorest SES quintiles become much stronger. The result s h o w so v e r8 0p e r c e n t( 0 . 5 4- (-0.29)) higher incidence of worse nutritional status among children in the poor- est quintile, than the ones hailing from richest SES group. However, such richest-poorest gap decreases with the phased introduction of covariates related to mother ’ s characteristics, household ethnicity and place of residence in the models (Table 3). Finally, similar to the initial estimate by OLS, the variance component models and random sl ope model indicates that the chil - dren with the most favorable SES background enjoy almost 50 percent better nutritional status than their counterpart from the poorest SES groups. The calculated ICC coefficient values presented in Table 4 differ from zero. This indicates that child nutri- tion is indeed correlated with households and commu- nities (PSUs ). The ICC for household lev el shows much higher correlation than the case of PSUs. The lower panel of the Table 4 shows how the resi- dual variance is distributed across PSUs and households. Estimates f rom model 1(null model) , which contains no observed covariates, indicate that the variation in height-for-age has substanti al group level components. The total variance 0. 548 (combined for PSU and house- holds estimates), of which 63 percent is attributed to household level variation i n anthropometric scores. Consistent wit h this observation on null model var iance decomposition, other model specifications show similar variance distribution pattern across state, PSU and household levels. Estimation of househo ld random effects (Table 4) indi- cates that h ousehold heterog eneity is accounte d for only partially by the covariates in our model (Model_Full & Model_random_slope). In other words the significantly different values of s 2 c and s 2 h indicates that the Table 3 Association ( b s) fro m Ordinary Least Squares and Multilevel Linea r Regression Models (Main Effects) between Child Stunting (Height for Age) and Household Socio-Economic Status, controlling for various other covariates; Fifteen Major States, India, NFHS-3 (Continued) Madhya Pradesh 0.025 (0.056) - 0.062 (0.071) 0.069 (0.067) 0.032 (0.067) 0.034 (0.067) Gujarat -0.307*** (0.063) - -0.281*** (0.079) -0.272*** (0.074) -0.314*** (0.075) -0.311*** homogeneity withi n cluster observations is not explai ned by the observed covariates s pecified in the model. The intra-household correlation remains as large as 0.242 suggesting that the height outcomes of two children belonging to the same family are more ho mogenous than those of two children chosen at random, even after adjusting for other observed covariates (Model_Full). household level denotes existence of higher homogeneity at the household level. These results further imply that choice of one-level model with the similar data set might yield underestimation of parameters. Discussion Successive waves of NFHS brings to the fore wid espread under nutrition among the Indian children, however it shows a declining trend duri ng the inter survey period. Though, the latest estimates as provided by the NFHS 3, highlights the cont inuance of high overall levels of child malnutrition in India. As we find here, prevalence of states and also across rural and urban areas. It needs special mention that chronic malnutrition among chil- dren is more concentrated among urban poor compared to their counterpart living in rural areas (Table 2) where inequalitie s are not as great but overall lev els of malnu- trition are higher. This trend is consistent across all thirteen states, except for Bihar and Kerala; where con- centration of stunting is observed higher among poor children from rural areas. The intra-stat e inequality in child m alnutrition is stark as we find through the divergent values of the Concentra- tion Index highlighting the disproportionate burden among the poor. The variance component models clearly show clustering o f observation at community and ho use- hold levels. In othe r words, for the fifteen major states in India, children in the households that shared similar communities do posses similar n utritional status. Intra- household corr elation is the most substantia l, comparing intra-PSU correlation. In other words, children from a cluster or community do not se em to share stronger cor- relation in terms of their nutritional status. But, at the household level the observations are not independent. It implies the fact that children belonging to a particular household do share certain common characteristics while growing up. The children who belong to households from the poorest SES quintile have higher prevalence of worse nutrit ional status. While, on t he contrary the chil- dren hailing from richest asset quintile households are associated with better nutrit ional status. The finding is supportive of many earlier observations made based on NFHS data [2]. Such association is consistent across the different models applied to the researc h (Table 4); recon- firming better nutritional status among children with favourable household socio -economic background, even after controlling for a range of individual, maternal and community characteristics. T his further emphasizes the impact of differential available resources to the families that act as a major determinant of malnutrition. The finding is supportive of studies conducted even in other countries [60]. Hence the gradient of household socio- economic status remains as a crucial determi nant of level of nutritional achievement among children. Betterment of such condition thus is exp ected to improve growth of children likely through better nutritional intake and reduced morbidity. Table 4 Random Coefficients, Intra-class correlation and Variance Decomposition estimates from comparative models Null_model Model_Kids Model_Mom Model_Full Model_Random_Slope Random Effects s 2 c (Community - PSU) 0.202 0.091 0.056 0.055 0.055 (S.E.) (0.014) (0.009) (0.008) (0.008) (0.008) Proportions of overall (null model) explained by the covariates of the model (in %) 55.189 72.149 72.850 72.875 s 2 h (Household) 0.346 0.462 0.436 0.431 0.366 (S.E.) (0.027) (0.025) (0.025) (0.025) (0.030) Proportions of overall (null model) explained by the covariates of the model (in %) -33.578 -26.086 -24.575 -5.683 Residual 2 1.877 1.516 1.514 1.518 1.516 (S.E.) (0.029) (0.024) (0.025) (0.025) (0.025) Intra-class correlation r (PSU) 0.083* 0.044* 0.028* 0.027* 0.028* r (household) 0.226* 0.267* 0.245* 0.242* 0.217* Variance Decomposition (in %) PSU 36.9 16.4 11.4 11.3 13.1 Household 63.1 83.6 88.6 88.7 86.9 Significance level: * p<0 5 Kanjilal et al . International Journal for Equity in Health 2010, 9 :19 However, at the more macro level i t is seen that abso- lute levels of malnutrition prevalence across th e states is not necessarily linearly correlated with the intra-state inequality in malnutrition prevalence. In other words, states that records higher prevalence of childhood mal- nutrition are not always reflective of the disproportion- ate burden shared by the poorest households. Mazumdar (fo rthcoming) [61], while exploring the link- age between povert y and inequality with child malnu tri- tion in India suggests a po ssible conformation of malnutrition inequality wi th overall socioeconomic inequality that exists in the states. We too identify a similar pattern; though with overall economic develop- ment measured throug h NSDP is found to be negatively correlated with the proportion of stunted children in the state, emphasizing the role of development that pro- motes equity in better nutritional outcome; the pattern cannot be generalized. In states like Punjab and Kerala with better develop- ment, a typical scenario emerges. Here, higher inequality in malnutrition pr evalence can be observed at the lower levels of percentage of stun ted children. On the other hand, states like Madhya Pradesh, Bihar, Gujarat and Rajasthan the states wit h less economic develop ment or at par with the national average, though have consider- ably high prevalence of malnutrition exhibited lower values of the concentration index suggesting lower levels of inequality. It is particularly since a higher average implies prevalence of malnutrition irrespective of SES with fewer differentials. Hence a clear gradient of mal- nutrition inequality, biased against the poor is more pro- nounced in states where absolute levels of malnutrition are low. This is largely due to the overall inequality in household ass et [50,62] among the states, wi th the poor accounting for a major share of the malnourished children. On the other hand, the states with higher levels of child malnutrition, generally tend to have a uniform dis- nomic distribution (Mazumdar forthcoming )[ 6 1 ] ,a n d the poor in states with lower observed levels sharing a higher disproportionate burden, vis-à-vis the poor in the former group of states. The situation in Orissa is however the worst and do es not confirm to any of the pattern discussed above. Here, with much lower per-capita NSDP as compared to the national average, the state exhibits a noticeably higher burden of chronic malnourishment among the poor. Hence, perhaps economic development cannot be con- sidered as the straightforward indicator for removing overall disparity in various input and outcome indicators among different income bracket, especially in a country like India. It is argued that reduction in child malnutri- tion does not seem to depend so much on economic growth of a state per se or even on the efforts at redu- cing income poverty at the state level [3]. Achieving bet- ter nutritional status among children is found sharing close nexus with the household socio-economic condi- tions, efforts to influence households ’ economic status thus might prove to be b eneficial. Alternatively, one can only think of successf ul targeted interventions to ensur e nutritiona l status among chil dren those belong to unfa- vorable asset bracket. Nevertheless, this issue of malnutrition and poverty deserves special treatment incorporating other para- meters reflecting the possible predictors of overall socio- economic inequality and its bearing on malnutrition inequality among the states, as future research in this area. Attempts can be worthwhile to know the reasons why the states with better economic development coupled with noticeable success in arresting the overall level of chronic child malnutrition, have failed to remove its disproportion ate prevalence across the socio- economic classes. It can be said that prevalence of worse nutritio nal status among children in Indi a cannot be addressed with utmost success unless, inequality in prevalence across soci o-economic classes ar e taken care of. A more state spec ific policy should be designed o n a priority basis, to arrest such unequal prevalence. Conclusions Regional hete rogeneity in malnutrit ion across the major states and rural-urban locations are observed to be widespread during NFHS-3. The concerns amplify with the disproportionate burden of malnutrition among malnutrition is seen to be at the lower level, but where they are experiencing better status of economic develop- ment. Multilevel analyses with introduction of controls on various covariates continue to indicate the household SES-undernutrition gradi ent. Hence, an appropriate pol- icy guideline that focuses on altering the nutritional intake among the poor children, especially in the states with apparent lower prevalence of childhood malnutri- tion is need of the hour. In the high prevalence states much stronger programme are awaited to reduce the overall level. More focused programme attention tar- geted at the poor to enhance the level of nutrition and behavior al changes, through i nterventions lik e the posi- tive deviance approach in a state like Orissa should be further expanded in the near future. Acknowledgements The authors acknowledge the scientific support extended by ‘ Future Health Systems: Innovations for equity ’ (http://www.futurehealthsystems.org) a research program consortium of researchers from Johns Hopkins University Bloomberg School of Public Health (JHSPH), USA; Institute of Development Studies (IDS), UK; Center for Health and Population Research (ICDDR, B), Bangladesh; Indian Institute of Health Management Research (IIHMR), India; Kanjilal et al . International Journal for Equity in Health 2010, 9 :19 59. Shroff M, Griffiths P, Adair L, Suchindran C, Bentley M: Maternal autonomy is inversely related to child stunting in Andhra Pradesh, India. Maternal and Child Nutrition 2009, 5 :64-74. 60. Beenstock M, Sturdy P: The determinants of infant mortality in regional India. World Development 1990, 18(3) :443-453. 61. Mazumdar S: Determinants of Inequality in Child Manutrition in India: The Poverty-Undernutrition Linkage. Asian Population Studies 2010. 62. Van De Poel E, Hosseinpoor AR, Speybroeck N, van Ourti T, Vega J: Socioeconomic Inequality in Malnutrition in Developing Countries. Bulletin of the World Health Organization 2008, 86 :282-291. doi:10.1186/1475-9276-9-19 Cite this article as: Kanjilal et al .: Nutritional status of children in India: household socio-economic condition as the contextual determinant. ... Nearly 165 million children, under the age of five, are malnourished in LMICs [4]. The proportion of undernourished children in 2017 accounted for 20.4% in Africa, 11 .4% in certain regions in Asia, and 6.1% in Latin America. Evidence indicates an increase in undernourishment and severe food insecurity in almost all the regions of Africa and South America, whereas, the undernourishment situation in Asia is observed to be stable [7]. ... ... A malnourished child is ten times more likely to die than a well-nourished child from a preventable cause [9]. The nutritional status of under-5 children in India, estimated using the anthropometric data on height and weight collected in the fifth round of the National Family Health Survey (NFHS-5;2019-20), indicates that 35·4% are stunted (height-for-age deficit), 32·08% are underweight Dialogues in Health 2 (2023) 100135 (weight-for-age deficit), and 19·35% are wasted (weight-for-height deficit) [10] India's progress in childhood nutrition status does not commensurate with its economic progress, and it is worse off than most Sub-Saharan nations [11] This paradoxical situation in India, as in most other South-Asian countries, is called the 'Asian Enigma'. ... ... Most studies treat tribal communities as an egalitarian group with a collective conscience, and, fail to capture and address the question of differentiation and inequality among them. Even though since Independence, various publicly financed initiatives have significantly improved the overall living conditions of the Tribal population across India, the inequality across all social classes and within ST communities continues [11, 22]. Such inequalities are also reflected in the health status of the ST population. ... Wealth inequalities in nutritional status among the tribal under-5 children in India: A temporal trend analysis using NFHS data of Jharkhand and Odisha states - 2006-21 Umakant Dash ... It is observed from NFHS-3 and NFHS-4 reports that the scenario of child malnutrition in West Bengal is lower than the national average, but the prevalence of malnutrition is not evenly distributed across the districts of the state (IIPS, 2017(IIPS, , 2021. Moreover, there are different studies done considering the role of bio-demographic factors in the prevalence of child malnutrition across the country (Kanjilal et al., 2010; Bisai et al., 2014;Panigrahi & Das, 2014;Amruth et al., 2015;Rengma et al., 2016;Ansuya et al., 2018; Aayog, 2021a), has been considered to study the prevalence of child malnutrition (Fig. 1). The proportion of rural populations in the district is 87.26%, which is quite high. ... ... But in this globalized world of the twenty-first century, the incidence of undernutrition is experienced by a wide range of pockets across the globe (UNICEF et al., 2019). Several studies observed that the bio-demographic and socioeconomic factors, such as BMI of mother, marriage age of mother, child birth weight, number of siblings, birth order, food intake, family income, education of parents, sanitation facility, source of drinking water, have a direct bearing in the prevalence of malnutrition of children (de Onis & Blossner, 1997;Cummins, 1998;Phillips, 2006; Kanjilal et al., 2010; Panigrahi & Das, 2014;Amruth et al., 2015;Rengma et al., 2016;Ansuya et al., 2018;De & Chattopadhyay, 2019;Islam & Biswas, 2020;Agarwal et al., 2021). In this present study, a total number of fifteen bio-demographic and socio-economic parameters are adopted as independent variables to find out the significant predictors of child malnutrition (Table 3). ... ... The prevalence of wasted children is observed in several works in different proportions across India, such as Arambag, West Bengal (2 to 6 years) 50% (Mandal et al., 2008); Paschim Medinipur, West Bengal (2 to 13 years) 22.70% (Bisai & Mallick, 2011); Paschim Medinipur, West Bengal (1 to 14 years) 19.40% (Bisai et al., 2008b); Darjeeling, West Bengal (5 to 12 years) 26.50% (Debnath et al., 2018); Odisha (1 to 6 years) 25% (Goswami, 2016); Assam (5 to 12 years) 17.15% ; Bhubaneswar, Orissa (3 to 9 years) 23.29% (Panigrahi & Das, 2014); Sullia, Karnataka (5 to 11 years) 26.50% (Amruth et al., 2015). It was documented in different studies that the variation in the prevalence of wasting mainly results from socio-economic-backgrounds and growth patterns of different age groups of children (Alemayehu et al., 2015;Amruth et al., 2015;Bisai et al., 2008aBisai et al., , 2008bDas & Bose, 2009;Debnath et al., 2018;Islam & Biswas, 2020; Kanjilal et al., 2010; Panigrahi & Das, 2014;Rengma et al., 2016;Singh, 2020;Stiller et al., 2020). The study does not observe any statistically significant difference in sex and age groups of children in the prevalence of wasting; it may be due to the low socio-economic profile of the households (Ghosh et al., 2021;Mandal, 2021;Mandal & Ghosh, 2019;Mandal et al., 2017). ... Rural child health in India: the persistent nature of deprivation, undernutrition and the 2030 Agenda ... A high-quality diet is typically comprised of regular consumption of fruits, vegetables, whole grains, lean sources of protein, and dairy products, and infrequent consumption of foods rich in sugar, salt, and fat that are low in nutritional density. On a shortterm basis, a high-quality diet in preschoolers is positively related to better cognitive development and a lower prevalence of childhood overweight and obesity [1] [2] [3][4][5] . Meanwhile, in the longer term, diet quality during preschool may act as a lifelong predictor for an individual's risk of having poor or good health during adolescence and beyond 1-3 . ... ... Meanwhile, in the longer term, diet quality during preschool may act as a lifelong predictor for an individual's risk of having poor or good health during adolescence and beyond 1-3 . In the era of economic achievement and the advancement of the health industrial revolution, it has not yet guaranteed a better diet quality and nutrition status among all preschool children in the country 2, 3 . must be studied because it is an indicator and predictor of their future wellbeing and health conditions in adulthood 4 . ... FAMILY FOOD CHOICES MOTIVE AMONG MALAYSIAN PRESCHOOL CHILDREN’S PARENTS It is important to determine the factors influencing the family, specifically the parent's food choice motives (FFCMs). These factors are perceived to relate to the nutritional status, eating habits of the children and, subsequently, their future well-being. This study aimed to determine the FFCMs factors (including health concerns, natural content, sensory appeal, convenience, weight control, price, mood, and familiarity) of the parents who had preschool children in Selangor, Malaysia. A cross-sectional study was conducted among seventy-six pairs of mothers and children aged 4 to 6 years in six selected preschools in the Klang Valley, Selangor. A set of self-administered questionnaires measuring demographic data, dietary records, and FFCMs of the parents were answered by the mother, and anthropometric measurements of the children were then taken. The mean FFCMs score found that "health" (mean 3.5 ± 0.53) was reported as the most important factor in parents' ’food choices than the "familiarity" factor (mean 2.78 ± 0.67). Compared to the ethnic groups, both Chinese and Indians mostly chose "natural content”, compared to Malay parents who chose "health" (3.55 ± 0.50) as an important factor to consider when choosing food. In conclusion, this study showed that by determining the most important factors influencing a family’s food choices, it is likely to improve the nutritional status and well-being of children and their family members. Thus, this study proposed the utilization of FFCMs as an instrument to design and develop food- and nutrition-related interventions for further studies. ... Reducing poverty and increasing access to services for those in need are crucial to improving childhood health and nutritional outcomes. Kanjilal, Mazumdar, Mukherjee and Rahman [5] found that stunting disproportionately affects children from poor socio-economic backgrounds across all Indian states, and that there is a negative correlation between Net State Domestic Product and stunting prevalence. Larrea and Kawachi, [6] investigated the effect of economic inequality on chronic child malnutrition while considering various household and individual determinants in Ecuador. ... A Study on Income Inequality and Nutritional Status of Children in Rural Areas of Jammu and Kashmir: Evidence from Jammu District, India Children nutritional status is a powerful indicator of nutrition security and well-being of individual and reflects the nutritional and poverty situation of household. Good nutritional status of children under five years of age is very crucial for the foundation of a healthy life. This study is a small attempt to highlight the extent of malnutrition in rural areas of Jammu district on the basis of households’ economic status. It empirically investigates the relationship between income inequality and nutritional status of children under age of five years of age (stunting) in the rural areas of Jammu district of Jammu and Kashmir. To determine the prevalence of undernutrition among different income groups of rural households, the study uses the data of a primary household survey. In order to measure the level of undernutrition (stunting), gender-specific anthropometric z-scores for height-for-age are calculated by using new child growth standards which are developed by the World Health Organisation (WHO). The study finds that children from households in the poorest quintile have significantly higher odds of stunting compared to those in the highest income quintile. The study revealed a negative association between income and the prevalence of stunting in the study area. It means the proportion of stunted children under five years of age decreases as the level of income increases among rural households. The study suggests that the government can help improve the nutritional status of children by taking important policy initiatives that addresses income inequality and poverty in rural areas. ... In spite of the implementation of Revamped Public Distribution System and Targeted Public Distribution System since the 1990s, and the enactment of the National Food Security Act, 2013, India is suffering from a serious and acute level of hunger and malnutrition. According to a report of the National Family Health Survey, approximately 38% of children under the age of 5 years are categorized within the range from moderate to severely stunted (based on height for age); overall, 46% of the children are categorized within the range from moderate to severely underweight (based on weight for age), and around 19% are categorized within the range from moderate to severely futile based on weight for height (Rajaram et al. 2007; ... Therefore, it is necessary to design region-specific public health policies (Yu et al., 2019) to find early intervention strategies and mitigate the human resource and economic burden of those regions and ultimately to India by investigating the nutritional status. Several studies are there in this regard in different regions (Swain et al., 2018; on different age groups Agarwalla et al., 2015;Padma et al., 2016) but most of the previous studies on nutritional status from Meghalaya, North-east India and Garos of East Garo Hills are conducted on children (Rao et al., 2005;Chyne et al., 2017;Singh et al., 2019;Meitei, 2020) and a very few on women (Chyne et al., 2017;Nongrum et al., 2021) while, research related to the prevalence of malnutrition among the adults (men and women) of North-eastern part of India, particularly from the Garo tribes of Meghalaya are meagre. ...
https://www.researchgate.net/publication/45628665_Nutritional_status_of_children_in_India_Household_socio-economic_condition_as_the_contextual_determinant
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