Prevalence and mortality of patients with multiple sclerosis in France in 2012: a study based on French health insurance data.
Data on the prevalence of multiple sclerosis (MS) in France are scarce. National and regional updated estimates are needed to better plan health policies. In this nationwide study, we provided estimates of the prevalence of MS in France in 2012 and mortality rate in 2013. MS cases were identified in the French national health insurance database (SNIIRAM-PMSI) using reimbursement data for disease-modifying treatment, long-term disease status for MS, disability pension for MS, and hospitalisation for MS (MS ICD-10 code: G35). We identified 99,123 MS cases, corresponding to an overall crude prevalence rate of 151.2 per 100,000 inhabitants [95% confidence interval (CI) 150.3-152.2]: 210.0 per 100,000 in women (95% CI 208.4-211.5) and 88.7 per 100,000 in men (95% CI 87.6-89.7). The overall prevalence rate was 155.6 per 100,000 inhabitants (95% CI 154.7-156.6) after standardization on the 2013-European population. We observed a prevalence gradient with a higher prevalence (190-200 per 100,000) in North-Eastern France and a lower prevalence in Southern and Western France (126-140). The crude mortality rate in 2013 was 13.7 per 1,000 MS cases (11.4 in women and 20.3 in men). The standardized mortality ratio was 2.56 (95% CI 2.41-2.72). Our results revise upwards the estimation of MS prevalence in France and confirm the excess mortality of MS patients compared to the general population.
['Foulon|Stéphanie|S|', 'Maura|Géric|G|', 'Dalichampt|Marie|M|', 'Alla|François|F|', 'Debouverie|Marc|M|', 'Moreau|Thibault|T|', 'Weill|Alain|A|']
D000293:Adolescent D000328:Adult D017677:Age Distribution D000368:Aged D000369:Aged, 80 and over D000465:Algorithms D016208:Databases, Factual D005260:Female D005602:France D006760:Hospitalization D006801:Humans D007348:Insurance, Health D038801:International Classification of Diseases D008297:Male D008875:Middle Aged D009103:Multiple Sclerosis D015995:Prevalence D012189:Retrospective Studies D055815:Young Adult
Prevalence Mortality Multiple sclerosis Epidemiology