Preparation and evaluation of three mucoadhesive dosage forms using (99m)Tc-Ofloxacin.
Preparation of three mucoadhesive formulations was optimized and pharmaceutically evaluated. Ofloxacin was radiolabeled with (99m)Tc and radiolabeled complex was characterized by HPLC. (99m)Tc-Ofloxacin was added as a tracer to the formulations namely Oflox C934, Oflox C940 and Oflox HPMC and the formulations were fed orally to rats. Imaging studies were carried out to assess the prolonged gastric retention of the formulations. (99m)Tc-Ofloxacin served as a good tracer for studying the pharmacokinetics of three controlled release mucoadhesive dosage forms by gamma scintigraphy studies.
['Mukherjee|Archana|A|', 'Sahoo|Subhashree|S|', 'Sarma|Haladhar Dev|HD|', 'Chakraborti|Chandra Kanti|CK|', 'Samuel|Grace|G|']
D000179:Acrylates D000180:Acrylic Resins D000818:Animals D003692:Delayed-Action Preparations D065347:Hypromellose Derivatives D007553:Isotope Labeling D008855:Microscopy, Electron, Scanning D015242:Ofloxacin D015609:Organotechnetium Compounds D011877:Radionuclide Imaging D019275:Radiopharmaceuticals D051381:Rats D017550:Spectroscopy, Fourier Transform Infrared D014961:X-Ray Diffraction
(99m)Tc–Ofloxacin Carbopol 934 Carbopol 940 Hydroxypropyl methyl cellulose (HPMC) Mucoadhesive suspension