Immunocompetent nontransgenic mouse models for studying hepatitis B virus immune responses.
Although the chronicity of hepatitis B virus (HBV) infection is the result of impaired HBV-specific immune responses that cannot eliminate or clear the infected hepatocytes efficiently, many issues remained unsettled. It is thus crucial to have a suitable laboratory animal to study the immunopathogenesis of HBV infection and the mechanisms of HBV persistence. To meet the requirement of a mouse model resembling natural chronic HBV infection in human, there are several approaches in the development of mouse animal model by using hydrodynamic-based transfection of HBV DNA, delivery of adenovirus or adeno-associated viral vectors containing HBV DNA for studying HBV immune responses. These immunocompetent nontransgenic mouse animal models will provide new approaches to investigate the mechanisms of immune pathogenesis in HBV infection.
['Tzeng|Horng-Tay|HT|', 'Hsu|Ping-Ning|PN|', 'Chen|Pei-Jer|PJ|']
D000256:Adenoviridae D000818:Animals D004279:DNA, Viral D000229:Dependovirus D004195:Disease Models, Animal D005822:Genetic Vectors D016679:Genome, Viral D006515:Hepatitis B virus D019694:Hepatitis B, Chronic D022781:Hepatocytes D006801:Humans D007121:Immunocompetence D051379:Mice D008810:Mice, Inbred C57BL D014162:Transfection
hepatitis B virus immune response mouse animal model