Anastomosing hemangioma: report of two renal cases and analysis of the literature.
BACKGROUND
Anastomosing hemangioma (AH) is a very rare vascular tumor mimicking angiosarcoma, predominately observed in kidney and less frequently in other organs. We present two new renal cases of AH at opposite ends of the clinical presentation spectrum, provide review of the literature and compare the epidemiological, clinical and pathological profiles of renal and non-renal cases.


CASE PRESENTATION
The first occurred in a 64-year-old woman presented with back pain and the second, a multifocal lesion, in a 47-year-old man with end stage renal disease (ESRD). Histology disclosed a vascular tumor with striking anastomosing pattern, minimal nuclear atypia and locally infiltrative pattern, mimicking superficially angiosarcoma. Extramedullary hematopoiesis, extensive perirenal fat entrapment and increased number of mast cells were additional features in the second lesion. Both patients are well, without disease, 25 and 14 months after diagnosis.


CONCLUSION
Comprehensive review and analysis of the published literature show that the growing number of non-renal AHs exhibits similar epidemiologic, clinical, biologic and histologic characteristics with renal AHs and most mild differences vanish after exclusion of cases associated with ESRD. Better understanding of AH pathogenesis will contribute to optimal treatment choices.
['Perdiki|Marina|M|', 'Datseri|Galateia|G|', 'Liapis|George|G|', 'Chondros|Nikolaos|N|', 'Anastasiou|Ioannis|I|', 'Tzardi|Maria|M|', 'Delladetsima|Johanna K|JK|', 'Drakos|Elias|E|']
D014408:Biomarkers, Tumor D005260:Female D006391:Hemangioma D006801:Humans D007150:Immunohistochemistry D007680:Kidney Neoplasms D008297:Male D008875:Middle Aged
Anastomosing Hemangioma Renal Review Non-renal