Pre-Hematopoietic Stem Cell Transplantation Lung Computed Tomography as an Alternative to the Pulmonary Function Test during the COVID-19 Pandemic.
The pulmonary function test (PFT) is an important test for risk stratification before allogeneic transplantation (allo-HCT). However, it might be preferable to avoid PFT as much as possible in the recent era of coronavirus disease 2019 (COVID-19), because PFT requires forced expirations and might produce aerosols, increasing the risk of COVID-19 transmission. Therefore, we tried to predict normal PFT results before allo-HCT based on computed tomography (CT) findings. This study included 390 allo-HCT recipients at our center for whom lung CT images and PFT results before allo-HCT were available. Abnormal CT findings were less likely to be observed in the normal PFT group (47.0% versus 67.4%, P = .015), with a high negative predictive value of 92.9%. In a multivariate analysis, normal CT was significantly associated with normal PFT (odds ratio, 2.47; 95% confidence interval, 1.22 to 4.97; P = .012). A model for predicting normal PFT was constructed based on the results of a multivariate analysis, and the area under the curve of the receiver operating characteristic analysis was 0.656, which gave a sensitivity of 45.5% and a specificity of 86.0%. The relatively high specificity of the model suggested that PFT can be omitted in patients with normal CT findings before allo-HCT.
['Tamaki|Masaharu|M|', 'Nakasone|Hideki|H|', 'Aikawa|Tadao|T|', 'Nakamura|Yuhei|Y|', 'Kawamura|Masakatsu|M|', 'Kawamura|Shunto|S|', 'Takeshita|Junko|J|', 'Yoshino|Nozomu|N|', 'Misaki|Yukiko|Y|', 'Yoshimura|Kazuki|K|', 'Matsumi|Shinpei|S|', 'Gomyo|Ayumi|A|', 'Tanihara|Aki|A|', 'Kusuda|Machiko|M|', 'Akahoshi|Yu|Y|', 'Kimura|Shun-Ichi|SI|', 'Kako|Shinichi|S|', 'Oyama-Manabe|Noriko|N|', 'Kanda|Yoshinobu|Y|']
D000293:Adolescent D000328:Adult D000368:Aged D000086382:COVID-19 D005260:Female D018380:Hematopoietic Stem Cell Transplantation D006801:Humans D008168:Lung D008297:Male D008875:Middle Aged D058873:Pandemics D012129:Respiratory Function Tests D012189:Retrospective Studies D000086402:SARS-CoV-2 D014057:Tomography, X-Ray Computed
Computed tomography Pulmonary function test COVID-19