Acute severe Cushing's disease presenting as a hypercoagulable state.
Cushing's disease (CD) is the most common cause of endogenous cortisol excess. We discuss the case of a 60-year-old woman with recurrent venous thromboembolism, refractory hypokalemia, and lumbar vertebrae compression fractures with a rapidly progressive disease course. Ectopic hypercortisolism was suspected given the patient's age and rapid onset of disease. Investigations revealed cortisol excess from a pituitary microadenoma. This case demonstrates that CD can present with severe findings and highlights the increased risk of venous thromboembolism in hypercortisolism, especially in CD.
['Fariduddin|Maria Mohammed|MM|', 'Syed|Wajihuddin|W|', 'Divan|Vidita|V|', 'Nadkarni|Prashant|P|', 'Dhaliwal|Ruban|R|']
hypercoagulability Cortisol thromboembolism fracture Cushing’s disease