Imidazole-pyrazole hybrids: Synthesis, characterization and in-vitro bioevaluation against α-glucosidase enzyme with molecular docking studies.
Herein, substituted imidazole-pyrazole hybrids (2a-2n) were prepared via a multi component reaction employing pyrazole-4-carbaldehydes (1a-1d), ammonium acetate, benzil and arylamines as reactants. All the new compounds were characterized through their spectral and elemental analyses. Further these compounds were tested against α-glucosidase enzyme. The compounds 2k, 2l and 2n possessed good inhibition potencies, however, compounds 2f (IC50 value: 25.19 ± 0.004 μM) and 2m (IC50 value: 33.62 ± 0.03 μM) were the most effective compounds of the series. Furthermore, molecular docking helped to understand the binding interactions of 2f and 2m with the understudy yeast's α-glucosidase enzyme.
['Chaudhry|Faryal|F|', 'Naureen|Sadia|S|', 'Ashraf|Muhammad|M|', 'Al-Rashida|Mariya|M|', 'Jahan|Bakhat|B|', 'Munawar|Munawar Ali|MA|', 'Khan|Misbahul Ain|MA|']
D001665:Binding Sites D057075:Enzyme Assays D065089:Glycoside Hydrolase Inhibitors D007093:Imidazoles D062105:Molecular Docking Simulation D015394:Molecular Structure D011720:Pyrazoles D012441:Saccharomyces cerevisiae D000520:alpha-Glucosidases
Molecular modeling Multicomponent reactions Tetrasubstituted imidazoles α-Glucosidase inhibitors