Gene therapy with HSV encoding p55TNFR gene for HIV neuropathic pain: an evidence-based mini-review.
While effective antiretroviral treatment makes human immunodeficiency virus (HIV)-related death decreased dramatically, neuropathic pain becomes one of the most common complications in patients with HIV/acquired immunodeficiency syndrome (AIDS). The exact mechanisms of HIV-related neuropathic pain are not well understood yet, and no effective therapy is for HIV-pain. Evidence has shown that proinflammatory factors (e.g., tumor necrosis factor alpha (TNFα)) released from glia, are critical to contributing to chronic pain. Preclinical studies have demonstrated that non-replicating herpes simplex virus (HSV)-based vector expressing human enkephalin reduces inflammatory pain, neuropathic pain, or cancer pain in animal models. In this review, we describe recent advances in the use of HSV-based gene transfer for the treatment of HIV pain, with a special focus on the use of HSV-mediated soluble TNF receptor I (neutralizing TNFα in function) in HIV neuropathic pain model.
['Kanda|Hirotsugu|H|', 'Liu|Shue|S|', 'Kanao|Megumi|M|', 'Yi|Hyun|H|', 'Iida|Takafumi|T|', 'Huang|Wan|W|', 'Kunisawa|Takayuki|T|', 'Lubarsky|David A|DA|', 'Hao|Shuanglin|S|']
HIV neuropathic pain soluble TNF receptor and gene therapy