Combined effects of androgen anabolic steroids and physical activity on the hypothalamic-pituitary-gonadal axis.
Analysing effects of pharmaceutical substances and training on feedback mechanisms of the hypothalamic-pituitary-gonadal axis may be helpful to quantify the benefit of strategies preventing loss of muscle mass, and in the fight against doping. In this study we analysed combined effects of anabolic steroids and training on the hypothalamic-pituitary-gonadal axis. Therefore intact male Wistar rats were dose-dependently treated with metandienone, estradienedione and the selective androgen receptor modulator (SARM) S-1. In serum cortisol, testosterone, 17β-estradiol (E2), prolactin, inhibin B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), Insulin-like growth factor 1 (IGF-1), and thyroxine (T4) concentrations were determined. Six human volunteers were single treated with 1-androstenedione. In addition abusing and clean body builders were analysed. Serum concentrations of inhibin B, IGF-1, cortisol, prolactin, T4, thyroid-stimulating hormone (TSH), testosterone and LH were determined. In rats, administration of metandienone, estradienedione and S-1 resulted in an increase of muscle fiber diameter. Metandienone and estradienedione but not S-1 administration significantly decreases LH and inhibin B serum concentration. Administration of estradienedione resulted in an increase of E2 and S-1 in an increase of cortisol. Single administration of 1-androstenedione in humans decreased cortisol and inhibin B serum concentrations. LH was not affected. In abusing body builders a significantly decrease of LH, TSH and inhibin B and an increase of prolactin, IGF-1 and T4 was detected. In clean body builders only T4 and TSH were affected.
['Hengevoss|Jonas|J|', 'Piechotta|Marion|M|', 'Müller|Dennis|D|', 'Hanft|Fabian|F|', 'Parr|Maria Kristina|MK|', 'Schänzer|Wilhelm|W|', 'Diel|Patrick|P|']
D000577:Amides D045930:Anabolic Agents D000735:Androstenedione D000814:Aniline Compounds D000818:Animals D004958:Estradiol D004963:Estrenes D005640:Follicle Stimulating Hormone D007987:Gonadotropin-Releasing Hormone D006801:Humans D006854:Hydrocortisone D007030:Hypothalamo-Hypophyseal System D007265:Inhibins D007279:Injections, Subcutaneous D007334:Insulin-Like Growth Factor I D007986:Luteinizing Hormone D008297:Male D008696:Methandrostenolone D009043:Motor Activity D018485:Muscle Fibers, Skeletal D010913:Pituitary-Adrenal System D011388:Prolactin D051381:Rats D017208:Rats, Wistar D013737:Testis D013739:Testosterone D013974:Thyroxine
Anabolic steroids Training SARMs Hypothalamic–pituitary–gonadal axis