Synthesis of novel β-carboline based chalcones with high cytotoxic activity against breast cancer cells.
A series of novel β-carboline based chalcones was synthesized and evaluated for their cytotoxic activity against a panel of human cancer cell lines. Among them we found that two of the compounds 7c and 7d, showed marked anti-proliferative activity in a panel of solid tumor cell lines with highest effect in breast cancer. The compounds 7c and 7d showed an IC50 of 2.25 and 3.29 μM, respectively against human breast cancer MCF-7 cell line. Further, the compound 7c markedly induced DNA fragmentation and apoptosis in breast cancer cells.
['Chauhan|Shikha S|SS|', 'Singh|Anup K|AK|', 'Meena|Sanjeev|S|', 'Lohani|Minaxi|M|', 'Singh|Akhilesh|A|', 'Arya|Rakesh K|RK|', 'Cheruvu|Srikanth H|SH|', 'Sarkar|Jayanta|J|', 'Gayen|Jiaur R|JR|', 'Datta|Dipak|D|', 'Chauhan|Prem M S|PM|']
D000818:Animals D000970:Antineoplastic Agents D017209:Apoptosis D002243:Carbolines D045744:Cell Line, Tumor D049109:Cell Proliferation D047188:Chalcones D002522:Chlorocebus aethiops D053938:DNA Fragmentation D004305:Dose-Response Relationship, Drug D004354:Drug Screening Assays, Antitumor D006801:Humans D061986:MCF-7 Cells D051379:Mice D015394:Molecular Structure D013329:Structure-Activity Relationship D014709:Vero Cells
β-Carboline Chalcone Cytotoxic Anticancer