Cerebrospinal fluid levels of orexin-A and histamine, and sleep profile within the Alzheimer process.
To better understand how sleep/wake dysregulation affects Alzheimer's disease (AD), we compared the cerebrospinal fluid (CSF) orexin and histamine/tele-methylhistamine (HA/t-MHA) levels of 82 patients (41 probable-AD-high level of evidence, 41 mild cognitive impairment MCI-due-to-AD), 24 other neurologic disorders (OND) and 24 controls. We determined the relationships between these biomarkers, the CSF AD biomarkers concentrations, and the clinical sleep profile. CSF orexin-A but not HA/t-MHA levels were higher in MCI and AD than OND and controls. CSF orexin-A is correlated to CSF amyloid-β42in MCI and AD, independently of age, gender, MMSE, total-tau/phosphorylated-tau, HA or sleep parameters. Nighttime sleep duration was longer in MCI and AD patients than controls. In MCI, nighttime sleep duration negatively correlated with CSF amyloid-β42 and MMSE. To conclude, CSF orexin-A but not HA/t-HMA was upregulated in AD and correlated with amyloid-β42 level. Our data suggested a change in the sleep-wake pattern at an early stage of the disease that needs further investigation to deeply explain the mechanistic interplay between sleep and Alzheimer.
['Gabelle|Audrey|A|', 'Jaussent|Isabelle|I|', 'Hirtz|Christophe|C|', 'Vialaret|Jérôme|J|', 'Navucet|Sophie|S|', 'Grasselli|Caroline|C|', 'Robert|Philippe|P|', 'Lehmann|Sylvain|S|', 'Dauvilliers|Yves|Y|']
D000368:Aged D000369:Aged, 80 and over D000544:Alzheimer Disease D016229:Amyloid beta-Peptides D015415:Biomarkers D060825:Cognitive Dysfunction D005260:Female D006632:Histamine D006801:Humans D008297:Male D008761:Methylhistamines D008875:Middle Aged D000068797:Orexins D010446:Peptide Fragments D012890:Sleep D014851:Wakefulness
Histamine Sleep Alzheimer Orexin Amyloid