The potentiated checkpoint blockade immunotherapy by ROS-responsive nanocarrier-mediated cascade chemo-photodynamic therapy.
Checkpoint inhibitors, such as anti-PD-1/PD-L1 antibodies, have been proven as a promising type of immunotherapy in a number of cancers, but the relatively low response rates limit their scope of clinical application. Here, we report the use of cascade chemo-photodynamic therapy (chemo-PDT) with reactive oxygen species (ROS)-sensitive lipid-polymer hybrid nanoparticles TKHNP-C/D to potentiate the antitumor efficacy of anti-PD-L1 antibody (aPD-L1). Under light irradiation, TKHNP-C/D not only induced photodynamic therapy (PDT) but also boosted intracellular DOX release via the rapid degradation of its hydrophobic core, promoting an efficient cascade of chemo-PDT to inhibit tumor growth by a single treatment. More importantly, the cascade chemo-PDT could evoke anticancer immune responses and efficiently synergize with aPD-L1 to generate an abscopal effect, which could simultaneously inhibit primary and distant tumor growth.
['Hu|Liqin|L|', 'Cao|Ziyang|Z|', 'Ma|Leilei|L|', 'Liu|Zhongqiu|Z|', 'Liao|Guochao|G|', 'Wang|Junxia|J|', 'Shen|Song|S|', 'Li|Dongdong|D|', 'Yang|Xianzhu|X|']
D000818:Animals D037282:Calreticulin D045744:Cell Line, Tumor D018920:Coculture Techniques D003102:Colloids D004337:Drug Carriers D007167:Immunotherapy D008055:Lipids D051379:Mice D050997:Nanomedicine D009368:Neoplasm Transplantation D009369:Neoplasms D010778:Photochemotherapy D017319:Photosensitizing Agents D011108:Polymers D017382:Reactive Oxygen Species
Checkpoint blockade immunotherapy Cascade chemo-PDT Cancer immunotherapy Cascade ICD-Inducing modalities ROS-Sensitive hybrid nanoparticle