COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes.
(1) This study aimed to evaluate characteristics, perinatal outcomes, and placental pathology of pregnant women with or without SARS-CoV-2 infection in the context of maternal PCR cycle threshold (CT) values. (2) This was a retrospective case-control study in a third-level health center in Mexico City with universal screening by RT-qPCR. The association of COVID-19 manifestations, preeclampsia, and preterm birth with maternal variables and CT values were assessed by logistic regression models and decision trees. (3) Accordingly, 828 and 298 women had a negative and positive test, respectively. Of those positive, only 2.6% of them presented mild to moderate symptoms. Clinical characteristics between both groups of women were similar. No associations between CT values were found for maternal features, such as pre-gestational BMI, age, and symptomatology. A significantly higher percentage of placental fibrinoid was seen with women with low CTs (<25; p < 0.01). Regarding perinatal outcomes, preeclampsia was found to be significantly associated with symptomatology but not with risk factors or CT values (p < 0.01, aOR = 14.72). Moreover, 88.9% of women diagnosed with COVID-19 at <35 gestational weeks and symptomatic developed preeclampsia. (4) The data support strong guidance for pregnancies with SARS-CoV-2 infection, in particular preeclampsia and placental pathology, which need further investigation.
['Laresgoiti-Servitje|Estibalitz|E|', 'Cardona-Pérez|Jorge Arturo|JA|', 'Hernández-Cruz|Rosa Gabriela|RG|', 'Helguera-Repetto|Addy Cecilia|AC|0000-0001-6715-9671', 'Valdespino-Vázquez|María Yolotzin|MY|', 'Moreno-Verduzco|Elsa Romelia|ER|', 'Villegas-Mota|Isabel|I|', 'Acevedo-Gallegos|Sandra|S|0000-0002-8037-2036', 'Rodríguez-Bosch|Mario|M|', 'León-Juárez|Moisés|M|0000-0002-5726-5953', 'Aguinaga-Ríos|Mónica|M|0000-0003-0590-3623', 'Coronado-Zarco|Irma|I|', 'Ortiz-Calvillo|Alejandro|A|0000-0001-6437-0500', 'Rivera-Rueda|María Antonieta|MA|', 'Valencia-Contreras|Carolina|C|', 'Gómez-Sousa|María de Lourdes|ML|', 'Solis-Paredes|Mario|M|0000-0003-4529-8296', 'Rodriguez-Aldama|Juan Carlos|JC|', 'Galván-Contreras|Rafael|R|', 'Figueroa-Damián|Ricardo|R|0000-0002-7749-2985', 'Cortés-Bonilla|Manuel|M|', 'Estrada-Gutierrez|Guadalupe|G|0000-0001-9551-9021', 'Espino-Y-Sosa|Salvador|S|0000-0001-7276-8463', 'Irles|Claudine|C|0000-0003-3952-4007']
D000328:Adult D001706:Biopsy D000086382:COVID-19 D005260:Female D006801:Humans D007150:Immunohistochemistry D018445:Infectious Disease Transmission, Vertical D010920:Placenta D016133:Polymerase Chain Reaction D011247:Pregnancy D011251:Pregnancy Complications, Infectious D011256:Pregnancy Outcome D012189:Retrospective Studies D000086402:SARS-CoV-2 D055815:Young Adult
pregnancy SARS-CoV-2 hypertensive disorder placenta