Hypertonic saline-hydroxyethyl starch solution attenuates fluid accumulation in cardiac surgery patients: a randomized controlled double-blind trial.
BACKGROUND
Significant fluid retention is common after cardiac surgery with the use of cardiopulmonary bypass (CPB). The aim of the study was to evaluate the effects of hypertonic saline-hydroxyethyl starch (HS-HES) solution on fluid accumulation in patients undergoing coronary artery bypass grafting surgery (CABG).


METHODS
Fifty adult male patients undergoing coronary bypass surgery were enrolled in this interventional, randomized, double-blinded study to compare HS-HES with saline solution. The study fluid (250 mL) was given into the venous reservoir of the CPB circuit at the time of aortic declamping.


RESULTS
Body mass change from the baseline to the first postoperative morning was significantly less in the HS-HES group compared with the control group (3.3 ± 1.5 kg vs. 4.4 ± 1.5 kg, P = 0.022). In the extracellular water (ECW) or ECW-balance, there were no significant differences between the groups. The need for fluids and diuretic medication did not differ between the groups during the perioperative period.


CONCLUSIONS
Our study shows that 250 mL of HS-HES solution can reduce perioperative fluid accumulation to some degree in patients undergoing CABG surgery with CPB.
['Järvelä|Kati|K|', 'Rantanen|Markku|M|', 'Kööbi|Tiit|T|', 'Huhtala|Heini|H|', 'Sisto|Tero|T|']
D000368:Aged D000369:Aged, 80 and over D001834:Body Water D001835:Body Weight D006348:Cardiac Surgical Procedures D001026:Coronary Artery Bypass D004232:Diuretics D004311:Double-Blind Method D005110:Extracellular Space D005440:Fluid Therapy D006801:Humans D006895:Hydroxyethyl Starch Derivatives D008297:Male D008875:Middle Aged D012462:Saline Solution, Hypertonic D016896:Treatment Outcome D014882:Water-Electrolyte Balance
hypertonic cardiopulmonary bypass coronary artery bypass saline solution water