Contrast-enhanced ultrasound and computerized tomography perfusion imaging of a liver fibrosis-early cirrhosis in dogs.
BACKGROUND AND AIM
To assess liver fibrosis stages in a liver fibrosis-early cirrhosis model in dogs, the clinical efficiency of contrast-enhanced ultrasound (CEUS) and computed tomography (CT) perfusion imaging were compared.


METHODS
Hepatic vein arriving time (HVAT), hepatic artery arriving time, and hepatic artery to vein transit time (HA-VTT) were measured on CEUS. Total liver perfusion (TLP), portal vein perfusion (PVP), hepatic artery perfusion, and hepatic perfusion index (HPI) were measured on CT perfusion imaging. Histologic examination of liver specimens of the animals was performed to assess the fibrosis stage.


RESULTS
For assessment of liver fibrosis, the area under the receiver operating characteristic curve of CEUS indexes HVAT and HA-VTT were 0.865 and 0.930, respectively; the perfusion CT indexes TLP, PVP, and HPI were 0.797, 0.800, and 0.220, respectively; the serological index hyaluronic acid was 0.793. While for assessment of early cirrhosis, the area under the receiver operating characteristic curve of CEUS indexes HVAT and HA-VTT were 0.915 and 0.948, respectively; the perfusion CT indexes TLP, PVP, and HPI were 0.737, 0.765, and 0.218, respectively; the serological index hyaluronic acid was 0.627.


CONCLUSIONS
This study showed that both CEUS and CT perfusion imaging have the potential to be complementary imaging tools in the evaluation of liver fibrosis. While CEUS is the better choice and the index HA-VTT can be considered as non-invasive semi-quantitative indexes for diagnosing liver fibrosis and early cirrhosis.
['Liu|Huanghui|H|', 'Liu|Jun|J|', 'Zhang|Yaqin|Y|', 'Liao|Jian|J|', 'Tong|Qiongjuan|Q|', 'Gao|Feng|F|', 'Hu|Yuequn|Y|', 'Wang|Wei|W|']
D000818:Animals D003287:Contrast Media D004195:Disease Models, Animal D018450:Disease Progression D004285:Dogs D005260:Female D006499:Hepatic Artery D006503:Hepatic Veins D061705:Image-Guided Biopsy D008099:Liver D008103:Liver Cirrhosis D008297:Male D012720:Severity of Illness Index D014057:Tomography, X-Ray Computed D014463:Ultrasonography
perfusion liver fibrosis contrast-enhanced ultrasound (CEUS) computer tomography (CT)