Fresh oocyte cycles yield improved embryo quality compared with frozen oocyte cycles in an egg-sharing donation programme.
The objective of this study was to investigate any effect of cryopreservation of donated eggs on laboratorial and clinical outcomes of intracytoplasmic sperm injection (ICSI) cycles. This retrospective cohort study included 320 oocyte recipients undergoing 307 vitrified and 119 fresh oocyte recipient ICSI cycles, participating in an egg-sharing donation programme, from 2015 to 2018, in a private university-affiliated in vitro fertilization (IVF) centre. A review of donor and recipient ICSI cycles was charted. A general mixed models fit by restricted maximum likelihood, followed by Bonferroni post hoc test was used to compare the means between fresh and warm oocyte donation groups and investigate the effect of cryopreservation on recipient ICSI outcome. The main outcome measure was blastocyst development rates. Fertilization rate, high-quality embryo rates on days 2 and 3, normal cleavage speed rates on days 2 and 3, and blastocyst development rate were significantly higher for the fresh oocyte donation cycles compared with warmed oocyte donation cycles. In the egg-sharing donation programme, fertilization and embryo developmental competence were reduced when vitrified oocytes from infertile couples were used for ICSI compared with fresh oocytes.
['Setti|Amanda Souza|AS|https://orcid.org/0000-0001-7869-5285', 'Braga|Daniela Paes de Almeida Ferreira|DPAF|', 'Iaconelli|Assumpto|A|', 'Borges|Edson|E|']
D015925:Cryopreservation D005260:Female D005307:Fertilization in Vitro D006801:Humans D018587:Oocyte Donation D009865:Oocytes D011247:Pregnancy D018873:Pregnancy Rate D012189:Retrospective Studies D058989:Vitrification
Oocyte Embryo Cryopreservation ICSI Vitrification