Parvovirus B19-Infected Tubulointerstitial Nephritis in Hereditary Spherocytosis.
Background
Human parvovirus B19 (B19V) causes glomerulopathy or microangiopathy, but not tubulopathy. We experienced an 11-year-old girl with spherocytosis who developed acute kidney injury on a primary infection of B19V. She presented with anuria, encephalopathy, thrombocytopenia, and coagulopathy, along with no apparent aplastic crisis.


Methods
Continuous hemodiafiltration, immunoglobulin, and intensive therapies led to a cure.


Results
A kidney biopsy resulted in a histopathological diagnosis of tubulointerstitial nephritis without immune deposits. The virus capsid protein was limitedly expressed in the tubular epithelial cells with infiltrating CD8-positive cells.


Conclusions
Viral and histopathological analyses first demonstrated B19-infected tubulointerstitial nephritis due to the aberrant viremia with hereditary spherocytosis.
['Nishiyama|Kei|K|0000-0002-2203-2156', 'Watanabe|Yuka|Y|', 'Ishimura|Masataka|M|', 'Tetsuhara|Kenichi|K|', 'Imai|Takashi|T|', 'Kanemasa|Hikaru|H|', 'Ueki|Kenji|K|', 'Motomura|Yoshitomo|Y|', 'Kaku|Noriyuki|N|', 'Sakai|Yasunari|Y|', 'Imadome|Ken-Ichi|KI|', 'Ohga|Shouichi|S|']
tubulointerstitial nephritis spherocytosis parvovirus B19