Sonication-assisted drug encapsulation in layer-by-layer self-assembled gelatin-poly (styrenesulfonate) polyelectrolyte nanocapsules: process optimization.
We report the development of Layer-by-Layer (LbL) polyelectrolyte self-assembled nanocrystalline drug-delivery platform using two experimental factors, namely the number of coatings and temperature during deposition with three varying levels. The optimized formulation (Fopt) was assessed for zeta potential and particle size using Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), and Scanning Electron Microscopy (SEM). Charge reversal along with an increase in particle size confirmed coating of polyelectrolyte on drug nanocrystals. The FT-IR study revealed no signs of incompatibility or change in formulation property during preformulation and stability study. This fact was further supported by DSC results.
['Pandey|Abhijeet P|AP|', 'Singh|Saurabh S|SS|', 'Patil|Ganesh B|GB|', 'Patil|Pravin O|PO|', 'Bhavsar|Chetan J|CJ|', 'Deshmukh|Prashant K|PK|']
D000894:Anti-Inflammatory Agents, Non-Steroidal D002152:Calorimetry, Differential Scanning D004337:Drug Carriers D004339:Drug Compounding D065546:Drug Liberation D004355:Drug Stability D004573:Electrolytes D005780:Gelatin D007700:Kinetics D053769:Nanocapsules D053758:Nanoparticles D010316:Particle Size D010894:Piroxicam D011137:Polystyrenes D013010:Sonication D017550:Spectroscopy, Fourier Transform Infrared D055672:Static Electricity D013696:Temperature
nanocrystals Design of experiments Lornoxicam probe sonication