Correlation of Plasma Level of Insulin-Like Growth Factor-1 (IGF-1) with Bacterial Index on Leprosy Patients in Bali.
Background
Leprosy is an infection by Mycobacterium leprae, which influenced by cellular immunity. Leprosy tends to occur in low socio-economic and nutrition groups. Researchers try to prove the role of nutrition in the pathogenesis of leprosy. Insulin-like growth factor-1 (IGF-1) as a marker of nutritional status shown to play a role in cellular immunity.


Objective
To evaluate the correlation between IGF-1 with bacterial index (BI) on leprosy patients in Bali.


Methods
Cross-sectional study in Sanglah Public General Hospital, Denpasar of patients with paucibacillary (PB) and multibacillary (MB) leprosy were assessed for BI using slit-skin smear. All patients were tested for plasma IGF-1 using chemiluminescent immunometric assay Immulite. All data were analyzed using IBM SPSS ver. 24.0. The study has been approved by local Institutional Review Board with ethical clearance number 2017.02.1.0356.


Results
Our study involved 44 MB and 2 PB leprosy. The common age group affected was between 31~40 years old (23.9%), male (60.9%), and normal body mass index (BMI) (65.2%). Mean plasma IGF-1 level in PB leprosy was higher (91.07±0.74 ng/ml) than MB (82.74±6.44 ng/ml). The mean IGF-1 level decreases as BI increases in both groups (CI 95%=81.16~85.04; p<0.001). Pearson correlation test shows strong negative correlation (Pearson r=-0.976; p<0.001) with determinant coefficient (R2) showing 95.2% (p<0.001).


Conclusion
In Balinese leprosy patients, severity of disease status measured by BI were found to be strongly correlated with the plasma IGF-1 level which may help preventing transmission in household contacts by improving nutritional status.
['Santosa|Calvin|C|https://orcid.org/0000-0002-0979-6522', 'Rusyati|Luh Made Mas|LMM|https://orcid.org/0000-0002-6986-5438', 'Adiguna|Made Swastika|MS|https://orcid.org/0000-0003-4097-8989', 'Praharsini|Igaa|I|https://orcid.org/0000-0003-0600-3029', 'Wiraguna|Aagp|A|https://orcid.org/0000-0002-7459-9103', 'Wardhana|Made|M|https://orcid.org/0000-0003-1161-0421']
Bacterial index Leprosy Insulin like growth factor 1