Effect of tooth loss and nutritional status on outcomes after ischemic stroke.
OBJECTIVES
Tooth loss, closely associated with malnutrition, increases the risk for cardiovascular disease. The aim of this study was to examine the link between tooth loss, nutritional status, and stroke outcomes.


METHODS
We retrospectively analyzed 195 consecutive patients with acute ischemic stroke who were evaluated for tooth loss. Tooth loss was classified as mild or severe. Nutritional status was evaluated using the Controlling Nutritional Status (CONUT) score. A poor neurologic outcome was defined as a score of 3 to 6 on the modified Rankin Scale at 3 mo post-stroke onset; a score of 0 to 2 was defined as a good outcome.


RESULTS
A significant correlation was observed between tooth loss and the CONUT score at admission (ρ = 0.156; P = 0.034). Patients with poor outcomes had higher CONUT scores (P < 0.001) and a greater frequency of severe tooth loss (P = 0.025). On multivariate analysis, severe tooth loss (odds ratio [OR], 3.93; 95% confidence interval [CI], 1.31-11.8) and the CONUT score (OR, 1.33; 95% CI, 1.02-1.74) were independently associated with poor stroke outcomes.


CONCLUSIONS
Nutritional status was associated with tooth loss among patients with acute ischemic stroke. Severe tooth loss and a higher CONUT score were independently associated with poor stroke outcomes.
['Shiga|Yuji|Y|', 'Nezu|Tomohisa|T|', 'Hosomi|Naohisa|N|', 'Aoki|Shiro|S|', 'Nishi|Hiromi|H|', 'Naito|Hiroyuki|H|', 'Kinoshita|Naoto|N|', 'Ueno|Hiroki|H|', 'Maruyama|Hirofumi|H|']
D000208:Acute Disease D000368:Aged D005260:Female D000082742:Heart Disease Risk Factors D006801:Humans D000083242:Ischemic Stroke D016015:Logistic Models D008297:Male D044342:Malnutrition D015999:Multivariate Analysis D015596:Nutrition Assessment D009752:Nutritional Status D011379:Prognosis D012189:Retrospective Studies D012720:Severity of Illness Index D016388:Tooth Loss
Tooth loss Nutritional status Ischemic stroke Controlling Nutritional Status (CONUT) score Poor outcome