Human Oral Stem Cells, Biomaterials and Extracellular Vesicles: A Promising Tool in Bone Tissue Repair.
Tissue engineering and/or regenerative medicine are fields of life science exploiting both engineering and biological fundamentals to originate new tissues and organs and to induce the regeneration of damaged or diseased tissues and organs. In particular, de novo bone tissue regeneration requires a mechanically competent osteo-conductive/inductive 3D biomaterial scaffold that guarantees the cell adhesion, proliferation, angiogenesis and differentiation into osteogenic lineage. Cellular components represent a key factor in tissue engineering and bone growth strategies take advantage from employment of mesenchymal stem cells (MSCs), an ideal cell source for tissue repair. Recently, the application of extracellular vesicles (EVs), isolated from stem cells, as cell-free therapy has emerged as a promising therapeutic strategy. This review aims at summarizing the recent and representative research on the bone tissue engineering field using a 3D scaffold enriched with human oral stem cells and their derivatives, EVs, as a promising therapeutic potential in the reconstructing of bone tissue defects.
['Trubiani|Oriana|O|0000-0002-7459-4898', 'Marconi|Guya D|GD|', 'Pierdomenico|Sante D|SD|', 'Piattelli|Adriano|A|', 'Diomede|Francesca|F|0000-0002-0384-6509', 'Pizzicannella|Jacopo|J|']
D000818:Animals D001672:Biocompatible Materials D015415:Biomarkers D001861:Bone Regeneration D003094:Collagen D000067128:Extracellular Vesicles D006801:Humans D010641:Phenotype D044968:Regenerative Medicine D013234:Stem Cells D023822:Tissue Engineering
oral stem cells biomaterials extracellular vesicles regenerative medicine bone regeneration