Low expression of collagen type-1 in sacrouterine ligament as risk factor of stage III-IV uterine prolapse.
BACKGROUND
Despite being non-life threatening, uterine prolapse is a reproductive health problem that interferes psychosocial life, economical and sexual function. Uterine prolapse can be caused by direct trauma resulting in damaged and weakened levator ani muscle which in turn causing sacrouterine ligament to stretch in order to maintain uterus normal position. The main component of sacrouterine ligament is collagen. Types of collagen that was involved in the occurrence of uterine prolapse are which plays a role of risk of occurrence uterine prolapse is collagen type-1 and type-3. Collagen type-1 has a good resistance and flexible to strain. If there is a disruption in the expression of collagen in sacrouterine ligament, it will result in cause uterine prolapse.


OBJECTIVE
The aim of this study is to prove low expression of collagen type-1 in sacrouterine ligament is a risk factor for the occurrence of stage III-IV uterine prolapse.


STUDY DESIGN
This study was an observational study using case-control approach. A total of 22 cases of stage III-IV uterine prolapse and 22 cases of non-uterine prolapse as control group were selected by consecutive sampling. This study was carried out in Sanglah General Hospital and Pathobiology Laboratory of Veterinary Faculty of Udayana. Samples were taken from sacrouterine ligament of individual with stage III-IV uterine prolapse compared to non-prolapse uterine who had undergone total hysterectomy.


RESULTS
Chi-square analysis with 95 % confidence interval indicated that low expression of collagen type-1 was 6 times more likely to be the risk factor of stage III-IV uterine prolapse (OR = 5.95; 95 %CI = 1.59-22.33; p = 0.006).


CONCLUSION
Low collagen type-1 in sacrouterine ligament is a risk factor of stage III-IV uterine prolapse.
['Mega Putra|I Gede|IG|', 'Ngurah Warsita|I Gusti|IG|', 'Suwiyoga|Ketut|K|', 'Fajar Manuaba|I B Gede|IBG|', 'Budiana|I Nyoman Gede|ING|', 'Putra Wiradnyana|A A Gede|AAG|']
D000328:Adult D000368:Aged D016022:Case-Control Studies D016009:Chi-Square Distribution D024042:Collagen Type I D005260:Female D006801:Humans D007044:Hysterectomy D008022:Ligaments D008875:Middle Aged D017773:Pelvic Floor D012307:Risk Factors D012447:Sacrum D014596:Uterine Prolapse D014599:Uterus
Collagen type-1 Stage III–IV uterine prolapse