CCN2 in Skin Fibrosis.
CCN2, formerly known as connective tissue growth factor, was discovered in 1991. Soon after its discovery, CCN2 was shown to be upregulated in response to the profibrotic cytokine transforming growth factor (TGF) β and to be constitutively overexpressed in fibrotic conditions. These early observations led to the hypothesis that CCN2 was a key regulator of fibrosis. However, only recently have data been generated that directly demonstrate this hypothesis. This review summarizes these observations and suggests a mechanism of action for CCN2.
['Leask|Andrew|A|']
D002454:Cell Differentiation D002465:Cell Movement D055513:Connective Tissue Growth Factor D005355:Fibrosis D015870:Gene Expression D006801:Humans D058628:Myofibroblasts D012871:Skin Diseases D013234:Stem Cells
CCN2 Adhesion CCN family CTGF Conditional knockout Contraction Type I collagen