The potential function of endometrial-secreted factors for endometrium remodeling during the estrous cycle.
Uterine has a pivotal role in implantation and conceptus development. To prepare a conducive uterine condition for possibly new gestation during the estrous cycle, uterine endometrium undergoes dramatic remodeling. In addition, angiogenesis is an indispensable biological process of endometrium remodeling. Furthermore, essential protein expressions related to important biological processes of endometrium remodeling, which are vascular endothelial growth factor (VEGF), myoglobin (MYG), collagen type IV (COL4), fucosyltransferase IV (FUT4), and cysteine-rich protein 2 (CRP2), were detected in the endometrial tissue reported in many previous studies and recently discovered in histotroph substrates during the estrous cycle. Those proteins, which are liable for provoking new vessel development, cell proliferation, cell adhesion, and cell migration, were expressed higher in the histotroph during the luteal phase than follicular phase. Histotroph proteins considerably contribute to endometrium remodeling during the estrous cycle. To that end, the following review will discuss and highlight the relevant information and evidence of the uterine fluid proteins as endometrial-secreted factors that adequately indicate the potential role of the uterine secretions to be involved in the endometrial remodeling process.
['Billhaq|Dody Houston|DH|', 'Lee|Sang-Hee|SH|', 'Lee|Seunghyung|S|0000-0001-5862-3663']
D043925:Angiogenesis Inducing Agents D000818:Animals D002352:Carrier Proteins D002448:Cell Adhesion D002465:Cell Movement D049109:Cell Proliferation D024141:Collagen Type IV D004717:Endometrium D030762:Estrous Cycle D005260:Female D060588:LIM Domain Proteins D009211:Myoglobin D042461:Vascular Endothelial Growth Factor A
estrous cycle angiogenesis endometrial remodeling