Glucosamine protects against radiation-induced lung injury via inhibition of epithelial-mesenchymal transition.
Radiotherapy is one of the most important treatments for chest tumours. Although there are plenty of strategies to prevent damage to normal lung tissues, it cannot be avoided with the emergence of radiation-induced lung injury. The purpose of this study was to investigate the potential radioprotective effects of glucosamine, which exerted anti-inflammatory activity in joint inflammation. In this study, we found glucosamine relieved inflammatory response and structural damages in lung tissues after radiation via HE staining. Then, we detected the level of epithelial-mesenchymal transition marker in vitro and in vivo, which we could clearly observe that glucosamine treatment inhibited epithelial-mesenchymal transition. Besides, we found glucosamine could inhibit apoptosis and promote proliferation of normal lung epithelial cells in vitro caused by radiation. In conclusion, our data showed that glucosamine alleviated radiation-induced lung injury via inhibiting epithelial-mesenchymal transition, which indicated glucosamine could be a novel potential radioprotector for radiation-induced lung injury.
['Lei|Xiao|X|0000-0002-0428-1749', 'Ma|Na|N|', 'Liang|Yanjie|Y|', 'Liu|Junyan|J|', 'Zhang|Pei|P|0000-0002-3297-899X', 'Han|Yanan|Y|', 'Chen|Wei|W|', 'Du|Lehui|L|', 'Qu|Baolin|B|']
D056809:Alveolar Epithelial Cells D000818:Animals D000893:Anti-Inflammatory Agents D017209:Apoptosis D003114:Colony-Forming Units Assay D004353:Drug Evaluation, Preclinical D058750:Epithelial-Mesenchymal Transition D005260:Female D005720:Gamma Rays D005944:Glucosamine D008168:Lung D051379:Mice D008810:Mice, Inbred C57BL D011658:Pulmonary Fibrosis D011833:Radiation Injuries, Experimental D017564:Radiation Pneumonitis D011837:Radiation-Protective Agents D051381:Rats
glucosamine lung tissues radiation EMT