Correlation of radiomic features on dynamic contrast-enhanced magnetic resonance with microvessel density in hepatocellular carcinoma based on different models.
OBJECTIVE
To explore the correlations of radiomic features of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with microvessel density (MVD) in patients with hepatocellular carcinoma (HCC), based on single-input and dual-input two-compartment extended Tofts (SITET and DITET) models.


METHODS
We compared the quantitative parameters of SITET and DITET models for DCE-MRI in 30 patients with HCC using paired sample t-tests. The correlations of SITET and DITET model parameters with CD31-MVD and CD34-MVD were analyzed using Pearson's correlation analysis. A diagnostic model of CD34-MVD was established and the diagnostic abilities of models for MVD were analyzed using receiver operating characteristic curve (ROC) analysis.


RESULTS
There were significant differences between the quantitative parameters in the two kinds of models. Compared with SITET, DITET parameters showed better correlations with CD31-MVD and CD34-MVD. The Ktrans and Ve radiomics features of the DITET model showed high efficiency for predicting the level of CD34-MVD according to ROC analysis, with areas under curves of 0.83 and 0.94, respectively.


CONCLUSION
Compared with SITET, the DITET model provides a better indication of the microcirculation of HCC and is thus more suitable for examining patients with HCC.
['Liang|Hongwei|H|', 'Hu|Chunhong|C|https://orcid.org/0000-0002-9513-9341', 'Lu|Jian|J|', 'Zhang|Tao|T|', 'Jiang|Jifeng|J|', 'Ding|Ding|D|', 'Du|Sheng|S|', 'Duan|Shaofeng|S|']
D006528:Carcinoma, Hepatocellular D003287:Contrast Media D006801:Humans D008113:Liver Neoplasms D008279:Magnetic Resonance Imaging D009682:Magnetic Resonance Spectroscopy D000082644:Microvascular Density D009389:Neovascularization, Pathologic
microvessel density Hepatocellular carcinoma magnetic resonance imaging dual-input two-compartment extended Tofts model hepatic artery portal vein single-input two-compartment extended Tofts model