Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury.
Curcumin is a naturally occurring polyphenol that is isolated from the rhizome of Curcuma longa (turmeric). This medicinal compound has different biological activities, including antioxidant, antibacterial, antineoplastic, and anti-inflammatory. It also has therapeutic effects on neurodegenerative disorders, renal disorders, and diabetes mellitus. Curcumin is safe and well-tolerated at high concentrations without inducing toxicity. It seems that curcumin is capable of targeting the Nrf2 signaling pathway in protecting the cells against oxidative damage. Besides, this strategy is advantageous in cancer therapy. Accumulating data demonstrates that curcumin applies four distinct ways to stimulate the Nrf2 signaling pathway, including inhibition of Keap1, affecting the upstream mediators of Nrf2, influencing the expression of Nrf2 and target genes, and finally, improving the nuclear translocation of Nrf2. In the present review, the effects of curcumin on the Nrf2 signaling pathway to exert its therapeutic and biological activities has been discussed.
['Ashrafizadeh|Milad|M|', 'Ahmadi|Zahra|Z|', 'Mohammadinejad|Reza|R|', 'Farkhondeh|Tahereh|T|', 'Samarghandian|Saeed|S|']
D000818:Animals D000893:Anti-Inflammatory Agents D000972:Antineoplastic Agents, Phytogenic D000975:Antioxidants D017209:Apoptosis D001682:Biological Availability D002316:Cardiotonic Agents D018899:CpG Islands D003474:Curcumin D019175:DNA Methylation D006801:Humans D007004:Hypoglycemic Agents D000072019:Kelch-Like ECH-Associated Protein 1 D007668:Kidney D008099:Liver D008168:Lung D051379:Mice D015394:Molecular Structure D018482:Muscle, Skeletal D051267:NF-E2-Related Factor 2 D018696:Neuroprotective Agents D018384:Oxidative Stress D008517:Phytotherapy D011837:Radiation-Protective Agents D055213:Retinal Pigment Epithelium D015398:Signal Transduction
Curcumin cancer nuclear factor erythroid 2-related factor 2 oxidative stress therapeutic effects.