Revised McDonald criteria for multiple sclerosis diagnostics in central Russia: sensitivity and specificity.
BACKGROUND
The 2010 revised McDonald criteria were developed with data gathered from Caucasian European and North American populations, and their applicability has been questioned for the Russian population.


OBJECTIVE
The objective of this report is to compare the specificity, accuracy, sensitivity and predictive value of MRI criteria incorporated to the new (2010) and old (2005) McDonald criteria for early multiple sclerosis (MS) diagnostics in the Nyzhnyi Novgorod (Russia) population.


METHODS
A total of 103 patients with symptoms suggestive of MS were recruited from 2008 to 2011 retrospectively. Patients were followed up until MS was confirmed or other proved diagnoses were determined. Their baseline and follow-up brain and spinal cord MRIs were retrospectively evaluated. Sixty-two patients (60%) converted to MS during the follow-up period (mean in 11±4.2 months).


RESULTS
In 41 cases (38%) diagnoses another than MS were established. The sensitivity, specificity, accuracy, PPV and NPV of the revised MRI criteria were 74%, 93%, 82%, 94%, 70%, respectively.


CONCLUSIONS
Despite the limitations of our study, we conclude that the ability of the revised MRI criteria for early MS diagnostics in the Russian population is approximately similar to that determined by the international panel in Europe.
['Belova|A N|AN|', 'Shalenkov|I V|IV|', 'Shakurova|D N|DN|', 'Boyko|A N|AN|']
D000328:Adult D001921:Brain D015331:Cohort Studies D042241:Early Diagnosis D005260:Female D006801:Humans D008279:Magnetic Resonance Imaging D008297:Male D009103:Multiple Sclerosis D011237:Predictive Value of Tests D012189:Retrospective Studies D012426:Russia D012680:Sensitivity and Specificity D013116:Spinal Cord D055815:Young Adult
Multiple sclerosis MRI