Stability of Cefazolin in Polyisoprene Elastomeric Infusion Devices.
PURPOSE
The aim was to investigate the stability of cefazolin in elastomeric infusion devices.


METHODS
Elastomeric devices (Infusor LV) that contain cefazolin (3 g/240 mL and 6 g/240 mL) were prepared and stored at 4°C for 72 hours and then at 35°C for 12 hours, followed by 25°C for 12 hours. An aliquot was withdrawn at predefined time points and analyzed for the concentration of cefazolin. Samples were also assessed for changes in pH, solution color, and particle content.


FINDINGS
Cefazolin retained acceptable chemical and physical stability over the studied storage period and conditions.


IMPLICATIONS
These findings will allow the administration of cefazolin by the Infusor LV elastomeric device in the outpatient and remote settings.
['Patel|Rahul P|RP|', 'Jacob|Jilson|J|', 'Sedeeq|Mohammed|M|', 'Ming|Long Chiau|LC|', 'Wanandy|Troy|T|', 'Zaidi|Syed Tabish R|STR|', 'Peterson|Gregory M|GM|']
D002437:Cefazolin D004355:Drug Stability D020724:Elastomers D007260:Infusion Pumps
stability cefazolin elastomeric device continuous infusion high-performance liquid chromatography infective endocarditis