SOX11 and TP53 add prognostic information to MIPI in a homogenously treated cohort of mantle cell lymphoma--a Nordic Lymphoma Group study.
Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma, where survival has been remarkably improved by use of protocols including high dose cytarabine, rituximab and autologous stem cell transplantation, such as the Nordic MCL2/3 protocols. In 2008, a MCL international prognostic index (MIPI) was created to enable stratification of the clinical diverse MCL patients into three risk groups. So far, use of the MIPI in clinical routine has been limited, as it has been shown that it inadequately separates low and intermediate risk group patients. To improve outcome and minimize treatment-related morbidity, additional parameters need to be evaluated to enable risk-adapted treatment selection. We have investigated the individual prognostic role of the MIPI and molecular markers including SOX11, TP53 (p53), MKI67 (Ki-67) and CCND1 (cyclin D1). Furthermore, we explored the possibility of creating an improved prognostic tool by combining the MIPI with information on molecular markers. SOX11 was shown to significantly add prognostic information to the MIPI, but in multivariate analysis TP53 was the only significant independent molecular marker. Based on these findings, we propose that TP53 and SOX11 should routinely be assessed and that a combined TP53/MIPI score may be used to guide treatment decisions.
['Nordström|Lena|L|', 'Sernbo|Sandra|S|', 'Eden|Patrik|P|', 'Grønbaek|Kirsten|K|', 'Kolstad|Arne|A|', 'Räty|Riikka|R|', 'Karjalainen|Marja-Liisa|ML|', 'Geisler|Christian|C|', 'Ralfkiaer|Elisabeth|E|', 'Sundström|Christer|C|', 'Laurell|Anna|A|', 'Delabie|Jan|J|', 'Ehinger|Mats|M|', 'Jerkeman|Mats|M|', 'Ek|Sara|S|']
D000293:Adolescent D000328:Adult D000368:Aged D000971:Antineoplastic Combined Chemotherapy Protocols D014408:Biomarkers, Tumor D002648:Child D015331:Cohort Studies D019938:Cyclin D1 D005260:Female D006801:Humans D020522:Lymphoma, Mantle-Cell D008297:Male D009363:Neoplasm Proteins D009367:Neoplasm Staging D011379:Prognosis D055751:SOXC Transcription Factors D012720:Severity of Illness Index D016019:Survival Analysis D016896:Treatment Outcome D016159:Tumor Suppressor Protein p53
lymphoid malignancies molecular diagnostics prognostic factors