Persistent HIV Type 1 Seronegative Status Is Associated With Lower CD8+ T-Cell Activation.
We leveraged data from the Preexposure Prophylaxis Initiative (iPrEx), a global trial of preexposure chemoprophylaxis against human immunodeficiency virus type 1 (HIV-1) infection, to compare T-cell activation between those who remained negative for HIV-1 and those who became infected during the trial. The frequency of CD38(+)HLA-DR(+) CD8(+) T cells was greater in those who seroconverted, relative to the frequency in those who remained uninfected (1.30% vs 0.82%, respectively; P = .005). This translated to an odds ratio of 4.26 (95% confidence interval, 1.54-11.78) for the association between CD8(+) T-cell activation and infection with HIV-1. T-cell activation may be a biomarker for elevated HIV-1 infection risk.
['Kuebler|Peter J|PJ|', 'Mehrotra|Megha L|ML|', 'Shaw|Brian I|BI|', 'Leadabrand|Kaitlyn S|KS|', 'Milush|Jeffrey M|JM|', 'York|Vanessa A|VA|', 'Defechereux|Patricia|P|', 'Grant|Robert M|RM|', 'Kallás|Esper G|EG|', 'Nixon|Douglas F|DF|']
D051997:ADP-ribosyl Cyclase 1 D000293:Adolescent D000328:Adult D018414:CD8-Positive T-Lymphocytes D015658:HIV Infections D015497:HIV-1 D006684:HLA-DR Antigens D006801:Humans D008213:Lymphocyte Activation D008297:Male D008562:Membrane Glycoproteins D016176:T-Lymphocyte Subsets D055815:Young Adult
T-cell activation HIV-1 infection risk HESN