In utero exposure to triphenyltin disrupts rat fetal testis development.
Triphenyltin is an organotin that is widely used as an anti-fouling agent and may have endocrine-disrupting effects. The objective of the current study was to investigate effects of triphenyltin on the development of rat fetal testis. Female pregnant Sprague Dawley dams were gavaged daily with triphenyltin (0, 0.5, 1, and 2 mg/kg body weight/day) from gestational day 12 to day 21. Triphenyltin dose-dependently decreased serum testosterone levels (0.971 ± 0.072 and 0.972 ± 0.231 ng/ml at 1 and 2 mg/kg, respectively) from control level (2.099 ± 0.351 ng/ml). Triphenyltin at 1 and 2 mg/kg doses also induced fetal Leydig cell aggregation, decreased fetal Leydig cell size and cytoplasmic size. Triphenyltin decreased the expression levels of Lhcgr, Scarb1, Star, Cyp11a1, Cyp17a1, Insl3, Fshr, Pdgfa, and Sox9 by 0.5 mg/kg dose and above. However, triphenyltin did not affect Leydig and Sertoli cell numbers. In conclusion, the current study indicated that in utero exposure of triphenyltin disrupted fetal Leydig and Sertoli cell development.
['Ge|Fei|F|', 'Zheng|Wenwen|W|', 'Bao|Suhao|S|', 'Wu|Keyang|K|', 'Xiang|Saiqiong|S|', 'Chen|Wanwan|W|', 'Chen|Xiuxiu|X|', 'Mo|Jiaying|J|', 'Zhou|Songyi|S|', 'Wang|Yiyan|Y|', 'Lian|Qingquan|Q|', 'Ge|Ren-Shan|RS|']
D000818:Animals D005260:Female D047109:Fetal Development D007985:Leydig Cells D008297:Male D009947:Organotin Compounds D010575:Pesticides D011247:Pregnancy D011297:Prenatal Exposure Delayed Effects D051381:Rats D017207:Rats, Sprague-Dawley D012708:Sertoli Cells D013737:Testis D013739:Testosterone
Triphenyltin Testosterone Fetal Leydig cell Leydig cell aggregation Sertoli cell