Ten-year experience of esophageal endoscopic submucosal dissection of superficial esophageal neoplasms in a single center.
BACKGROUND/AIMS
Endoscopic submucosal dissection (ESD) of a superficial esophageal neoplasm (SEN) is a technically difficult procedure. We investigated the clinical outcomes of ESD to determine its feasibility and effectiveness for the treatment of SEN.


METHODS
Patients who underwent ESD for SEN between August 2005 and June 2014 were eligible for this study. The clinical features of patients and tumors, histopathologic characteristics, adverse events, results of endoscopic resection, and survival were investigated.


RESULTS
ESD was performed in 225 patients with 261 lesions, including 70 cases (26.8%) of dysplasias and 191 cases (73.2%) of squamous cell carcinomas. The median age was 65 years (range, 44 to 86), and the male to female ratio was 21.5:1. Median tumor size was 37 mm (range, 5 to 85) and median procedure time was 45 minutes (range, 9 to 160). En bloc resection was performed in 245 of 261 lesions (93.9%), with complete resection in 234 lesions (89.7%) and curative resection in 201 lesions (77.0%). Adverse events occurred in 33 cases (12.6%), including bleeding (1.5%), perforation (4.6%), and stricture (6.5%). During a median follow-up period of 35.0 months (interquartile range, 18 to 62), none of the patients showed local recurrence. The 5-year overall and disease-specific survival rates were 89.7% and 100%, respectively.


CONCLUSIONS
ESD is a feasible and effective procedure for the treatment of SEN based on our 10-year experience, which showed favorable outcomes.
['Park|Hyung Chul|HC|', 'Kim|Do Hoon|DH|', 'Gong|Eun Jeong|EJ|', 'Na|Hee Kyong|HK|', 'Ahn|Ji Yong|JY|', 'Lee|Jeong Hoon|JH|', 'Jung|Kee Wook|KW|', 'Choi|Kee Don|KD|', 'Song|Ho June|HJ|', 'Lee|Gin Hyug|GH|', 'Jung|Hwoon-Yong|HY|', 'Kim|Jin-Ho|JH|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D002294:Carcinoma, Squamous Cell D018572:Disease-Free Survival D000069916:Endoscopic Mucosal Resection D004938:Esophageal Neoplasms D000077277:Esophageal Squamous Cell Carcinoma D016629:Esophagectomy D004945:Esophagoscopy D005240:Feasibility Studies D005260:Female D006801:Humans D053208:Kaplan-Meier Estimate D008297:Male D008875:Middle Aged D011183:Postoperative Complications D012189:Retrospective Studies D012307:Risk Factors D066106:Seoul D013997:Time Factors D016896:Treatment Outcome
Endoscopic submucosal dissection Esophageal neoplasms En bloc resection