Polydeoxyribonucleotide Injection in the Treatment of Chronic Supraspinatus Tendinopathy: A Case-Controlled, Retrospective, Comparative Study With 6-Month Follow-Up.
OBJECTIVE
To determine the efficacy of polydeoxyribonucleotide (PDRN) injection for rotator cuff disease (RCD).


DESIGN
Case-controlled, retrospective, comparative study.


SETTING
Outpatient clinic at a university-affiliated tertiary care hospital.


PARTICIPANTS
Patients (N=106) with chronic nontraumatic refractory RCD who were unresponsive to at least 1 month of conservative treatment: 55 patients received PDRN injection (PDRN group) and 51 continued conservative treatment (control group).


INTERVENTIONS
Not applicable.


MAIN OUTCOME MEASURES
Shoulder Pain and Disability Index, score on a visual analog scale of the average shoulder pain level, number of analgesic ingestions per day, isometric strength of shoulder abductor, active range of motion (flexion, abduction, internal rotation, external rotation), and maximal tear size of tendon on ultrasonography at pretreatment and 3 and 6 months postinjection.


RESULTS
There was no significant difference between the 2 groups in terms of age, sex, shoulder affected, duration of symptoms, and ultrasonographic findings at pretreatment. Compared with the control group, the treatment group showed a significant improvement in Shoulder Pain and Disability Index, visual analog scale score, and number of analgesic ingestions per day. However, there was no difference in isometric strength, active range of motion, and maximal tear size of tendon. No adverse events were reported.


CONCLUSIONS
To our knowledge, this is the first study to assess the efficacy of PDRN injection for patients with RCD. The PDRN injection group showed improvement in pain and subjective disability in patients with RCD and continued to show improvement for 3 months thereafter; the PDRN injection can be an optional treatment for patients with chronic RCD who show no response to other treatments.
['Yoon|Young Chun|YC|', 'Lee|Doo-Hyung|DH|', 'Lee|Michael Young|MY|', 'Yoon|Seung-Hyun|SH|']
D000328:Adult D000368:Aged D016022:Case-Control Studies D005260:Female D006785:Hospitals, University D006801:Humans D007270:Injections, Intra-Articular D007537:Isometric Contraction D008297:Male D008875:Middle Aged D053580:Muscle Strength D018482:Muscle, Skeletal D010147:Pain Measurement D011089:Polydeoxyribonucleotides D016059:Range of Motion, Articular D012189:Retrospective Studies D000070636:Rotator Cuff Injuries D020069:Shoulder Pain D018084:Ultrasonography, Interventional
Tendinopathy Rotator cuff Shoulder pain Rehabilitation