Simultaneous measurement of nicotinamide and its catabolites, nicotinamide N-oxide, N(1)-methyl-2-pyridone-5-carboxamide, and N(1)-methyl-4-pyridone-3-carboxamide, in mice urine.
Nicotinamide N-oxide is a major nicotinamide catabolite in mice but not in humans and rats. A high-performance liquid chromatographic method for the simultaneous measurement of nicotinamide, nicotinamide N-oxide, N(1)-methyl-2-pyridone-5-carboxamide, and N(1)-methyl-4-pyridone-3-carboxamide in mice urine was developed by modifying the mobile phase of a reported method for measurement of nicotinamide N-oxide.
['Maeta|Akihiro|A|', 'Sano|Mitsue|M|', 'Fukuwatari|Tsutomu|T|', 'Shibata|Katsumi|K|']
D000818:Animals D051379:Mice D009536:Niacinamide D011728:Pyridones D013997:Time Factors D016482:Urinalysis
nicotinamide N-oxide urine HPLC mouse vitamin