Hydrophilic surface modification of acrylate-based biomaterials.
Acrylic polymers have proved to be excellent with regard to cell adhesion, colonization and survival, in vitro and in vivo. Highly ordered and regular pore structures thereof can be produced with the help of polyamide templates, which are removed with nitric acid. This treatment converts a fraction of the ethyl acrylate side groups into acrylic acid, turning poly(ethyl acrylate) scaffolds into a more hydrophilic and pH-sensitive substrate, while its good biological performance remains intact. To quantify the extent of such a modification, and be able to characterize the degree of hydrophilicity of poly(ethyl acrylate), poly(ethyl acrylate) was treated with acid for different times (four, nine and 17 days), and compared with poly(acrylic acid) and a 90/10%wt. EA/AAc copolymer (P(EA-co-AAc)). The biological performance was also assessed for samples immersed in acid up to four days and the copolymer, and it was found that the incorporation of acidic units on the material surface was not prejudicial for cells. This surface modification of 3D porous hydrophobic scaffolds makes easier the wetting with culture medium and aqueous solutions in general, and thus represents an advantage in the manageability of the scaffolds.
['Arnal-Pastor|M|M|', 'Comín-Cebrián|S|S|', 'Martínez-Ramos|C|C|', 'Monleón Pradas|M|M|', 'Vallés-Lluch|A|A|']
D000179:Acrylates D000180:Acrylic Resins D000818:Animals D001672:Biocompatible Materials D002460:Cell Line D002470:Cell Survival D005347:Fibroblasts D006863:Hydrogen-Ion Concentration D057927:Hydrophobic and Hydrophilic Interactions D051379:Mice D017942:Nitric Acid D016062:Porosity D013499:Surface Properties D054457:Tissue Scaffolds D017155:Wettability
surface modification nitric acid ethyl acrylate acrylic acid Scaffold