Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy.
Mesoporous carbon nanospheres containing porphyrin-like metal centers (denoted as "PMCS") are successfully synthesized by the pyrolysis of an imidazolate framework using a mesoporous-silica protection strategy. The PMCS allow infrared and photoacoustic imaging and synergetic photothermal therapy/photodynamic therapy derived from the porphyrin-like moieties, offering the possibility of real-time monitoring of therapeutic processes and image-guided precise conformal phototherapy. PMCS thus represent a novel multifunctional theranostic platform for improved treatment efficiencies.
['Wang|Shunhao|S|', 'Shang|Lu|L|', 'Li|Linlin|L|', 'Yu|Yingjie|Y|', 'Chi|Chongwei|C|', 'Wang|Kun|K|', 'Zhang|Jie|J|', 'Shi|Run|R|', 'Shen|Heyun|H|', 'Waterhouse|Geoffrey I N|GI|', 'Liu|Sijin|S|', 'Tian|Jie|J|', 'Zhang|Tierui|T|', 'Liu|Huiyu|H|']
D002244:Carbon D008670:Metals D054118:Nanospheres D010789:Phototherapy D011166:Porphyrins
porphyrin-like metal centers photothermal therapy photodynamic therapy mesoporous carbon nanoframes reactive oxygen species