α-Pyrone Polyketides from Streptomyces ambofaciens BI0048, an Endophytic Actinobacterial Strain Isolated from the Red Alga Laurencia glandulifera.
Four new (1-4) and six previously reported (5-10) α-pyrone polyketides, along with benzoic acid, hydrocinnamic acid, and (E)-cinnamic acid, were isolated from the organic extract resulting from the cultivation of the algicolous strain Streptomyces ambofaciens BI0048, which in turn was isolated from the inner tissues of the red alga Laurencia glandulifera. The structure elucidation of the isolated natural products was based on extensive analysis of their spectroscopic data (NMR, MS, UV, IR). Compounds 1-10 were evaluated for their antibacterial and cytotoxic activities against two multidrug-resistant strains of Staphylococcus aureus and one strain of Escherichia coli, as well as two human cancer cell lines.
['Rab|Enikő|E|', 'Kekos|Dimitrios|D|', 'Roussis|Vassilios|V|', 'Ioannou|Efstathia|E|']
D000900:Anti-Bacterial Agents D001688:Biological Products D045744:Cell Line, Tumor D024901:Drug Resistance, Multiple, Bacterial D060026:Endophytes D004926:Escherichia coli D006801:Humans D044722:Laurencia D008826:Microbial Sensitivity Tests D015394:Molecular Structure D061065:Polyketides D011753:Pyrones D013057:Spectrum Analysis D013211:Staphylococcus aureus D013302:Streptomyces
α-pyrone polyketides Streptomyces ambofaciens structure elucidation algicolous actinobacterium bioactivity evaluation endophytic strain