Poly (lactic acid)-based biomaterials for orthopaedic regenerative engineering.
Regenerative engineering converges tissue engineering, advanced materials science, stem cell science, and developmental biology to regenerate complex tissues such as whole limbs. Regenerative engineering scaffolds provide mechanical support and nanoscale control over architecture, topography, and biochemical cues to influence cellular outcome. In this regard, poly (lactic acid) (PLA)-based biomaterials may be considered as a gold standard for many orthopaedic regenerative engineering applications because of their versatility in fabrication, biodegradability, and compatibility with biomolecules and cells. Here we discuss recent developments in PLA-based biomaterials with respect to processability and current applications in the clinical and research settings for bone, ligament, meniscus, and cartilage regeneration.
['Narayanan|Ganesh|G|', 'Vernekar|Varadraj N|VN|', 'Kuyinu|Emmanuel L|EL|', 'Laurencin|Cato T|CT|']
D001672:Biocompatible Materials D006801:Humans D009985:Orthopedics D011091:Polyesters D012038:Regeneration D044968:Regenerative Medicine D023822:Tissue Engineering D054457:Tissue Scaffolds
Regenerative Engineering Poly (lactic acid) Bone Ligament Cartillage Growth factors Meniscus regeneration Small molecules