Long-term survival outcomes of repeat lumpectomy for ipsilateral breast tumor recurrence: a propensity score-matched analysis.
PURPOSE
This study aimed to compare long-term survival outcomes of repeat lumpectomy with total mastectomy after ipsilateral breast tumor recurrence (IBTR) using propensity score matching (PSM).


METHODS
We retrospectively analyzed patients with IBTR who had undergone initial breast-conserving surgery for breast cancer at our institution between January 1990 and December 2013. The Kaplan-Meier method and Cox proportional hazards model were used to compare survival rates between the two groups. PSM was performed using the following covariates: age at initial operation, initial T stage, N stage, hormone receptor status, human epidermal growth factor receptor 2 status, chemotherapy, radiotherapy, and IBTR tumor size.


RESULTS
We enrolled 335 IBTR patients with a median follow-up of 126.6 months. No significant differences were observed in the 5-year overall survival (OS), breast cancer-specific survival (BCSS), OS after IBTR, and BCSS after IBTR and 10-year survival probability between the two groups in a multivariate analysis. After PSM, patients who had undergone repeat lumpectomy and total mastectomy (n = 90 in both groups) were included. No significant differences were observed in the 10-year OS (hazard ratio [HR] 1.08, 95% confidence interval [CI] 0.49-2.39), BCSS (HR 0.83, 95% CI 0.35-1.95), OS after IBTR (HR 0.83, 95% CI 0.38-1.83), and BCSS after IBTR (HR 0.64, 95% CI 0.28-1.47) between the two groups.


CONCLUSIONS
No significant differences were observed in survival outcomes between patients with IBTR who underwent repeat lumpectomy or total mastectomy. Our results can be helpful in selecting the appropriate surgical method for IBTR.
['Baek|Soo Yeon|SY|', 'Kim|Jisun|J|', 'Chung|Il Yong|IY|', 'Ko|Beom Seok|BS|', 'Kim|Hee Jeong|HJ|', 'Lee|Jong Won|JW|', 'Son|Byung Ho|BH|', 'Ahn|Sei-Hyun|SH|', 'Lee|Sae Byul|SB|http://orcid.org/0000-0002-3370-6937']
D001943:Breast Neoplasms D005260:Female D006801:Humans D008408:Mastectomy D015412:Mastectomy, Segmental D009364:Neoplasm Recurrence, Local D057216:Propensity Score D012189:Retrospective Studies
Repeat lumpectomy Ipsilateral breast tumor recurrence Breast-conserving surgery Breast cancer