Coxfa4l3, a novel mitochondrial electron transport chain Complex 4 subunit protein, switches from Coxfa4 during spermatogenesis.
We identified Coxfa4l3, previously called C15orf48 or Nmes1, as a novel accessory protein of Complex IV of the mitochondrial electron transport chain (ETC). Amino acid sequence comparison, the intracellular localization and the protein expression data showed that the protein is the third isoform of Coxfa4 and the expression of Coxfa4 and Coxfa4l3 proteins during spermatogenesis showed a mutually exclusive pattern, implying that Coxfa4 replaces Coxfa4l3 in Complex IV after meiosis. These results may provide some insight into the unique mechanism of ATP production in late spermatogenesis.
['Endou|Masahiro|M|', 'Yoshida|Kaito|K|', 'Hirota|Makoto|M|', 'Nakajima|Chika|C|', 'Sakaguchi|Atsumi|A|', 'Komatsubara|Naoto|N|', 'Kurihara|Yasuyuki|Y|']
D000818:Animals D002460:Cell Line D003576:Electron Transport Complex IV D057809:HEK293 Cells D006367:HeLa Cells D006801:Humans D008297:Male D051379:Mice D009687:Nuclear Proteins D009928:Organ Specificity D040901:Proteomics D013091:Spermatogenesis
Electron transport chain Spermatogenesis Hypoxia