Inorganic arsenic causes apoptosis cell death and immunotoxicity on European sea bass (Dicentrarchus labrax).
Inorganic arsenic (As) is one of the most toxic pollutants in the water. We have studied their effects on the marine teleost European sea bass (Dicentrarchus labrax) at 2 and 10 days of 5 μM of As2O3 (sub-lethal doses) waterborne exposure. Arsenic accumulates in liver and gill tissues. The expression profile of five genes (bax, blc2, casp3, casp8 and casp9) involved in apoptosis cell death confirmed apoptotic effects in liver, slight changes in gill and no effects in skin according with the histopathology findings. Total IgM level and peroxidase activities were increased at 2 and 10 days, respectively. The bactericidal activity was decreased at 2 days after As exposure. A general decrease of cellular immune activities with significant differences in the case of respiratory burst activity was observed after 2 and 10 days of exposure. This work describes for the first time the effects of As exposure on European sea bass.
['Cordero|Héctor|H|', 'Morcillo|Patricia|P|', 'Martínez|Salvadora|S|', 'Meseguer|José|J|', 'Pérez-Sirvent|Carmen|C|', 'Chaves-Pozo|Elena|E|', 'Martínez-Sanchez|María José|MJ|', 'Cuesta|Alberto|A|', 'Ángeles Esteban|M|M|']
D000818:Animals D017209:Apoptosis D000077237:Arsenic Trioxide D001152:Arsenicals D001492:Bass D015870:Gene Expression D005880:Gills D007111:Immunity, Cellular D007075:Immunoglobulin M D008099:Liver D010087:Oxides D010587:Phagocytosis D014874:Water Pollutants, Chemical
Arsenic Apoptosis European sea bass (Dicentrarchus labrax) Immunotoxicology