Role of endoplasmic reticulum stress-induced apoptosis in rat thyroid toxicity caused by excess fluoride and/or iodide.
Excess fluoride and iodide coexist in drinking water in many regions, but few studies have investigated the single or interactive effects on thyroid in vivo. In our study, Wistar rats were exposed to excess fluoride and/or iodide through drinking water for 2 or 8 months. The structure and function of the thyroid, cells apoptosis and the expression of inositol-requiring enzyme 1 (IRE1) pathway-related factors were analyzed. Results demonstrated that excess fluoride and/or iodide could change thyroid follicular morphology and alter thyroid hormone levels in rats. After 8 months treatment, both single and co-exposure of the two microelements could raise the thyroid cells apoptosis. However, the expressions of IRE1-related factors were only increased in fluoride-alone and the combined groups. In conclusion, thyroid structure and thyroid function were both affected by excess fluoride and/or iodide. IRE1-induced apoptosis were involved in this cytotoxic process caused by fluoride or the combination of two microelements.
['Liu|Hongliang|H|', 'Hou|Changchun|C|', 'Zeng|Qiang|Q|', 'Zhao|Liang|L|', 'Cui|Yushan|Y|', 'Yu|Linyu|L|', 'Wang|Lingzhi|L|', 'Zhao|Yang|Y|', 'Nie|Junyan|J|', 'Zhang|Bin|B|', 'Wang|Aiguo|A|']
D000818:Animals D017209:Apoptosis D004357:Drug Synergism D059865:Endoplasmic Reticulum Stress D007452:Iodates D008565:Membrane Proteins D017680:Potassium Compounds D017346:Protein Serine-Threonine Kinases D017208:Rats, Wistar D012969:Sodium Fluoride D013960:Thyroid Function Tests D013961:Thyroid Gland
Rat Thyroid Fluoride Iodide Endoplasmic reticulum stress