Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis.
Interneurons navigate along multiple tangential paths to settle into appropriate cortical layers. They undergo a saltatory migration paced by intermittent nuclear jumps whose regulation relies on interplay between extracellular cues and genetic-encoded information. It remains unclear how cycles of pause and movement are coordinated at the molecular level. Post-translational modification of proteins contributes to cell migration regulation. The present study uncovers that carboxypeptidase 1, which promotes post-translational protein deglutamylation, controls the pausing of migrating cortical interneurons. Moreover, we demonstrate that pausing during migration attenuates movement simultaneity at the population level, thereby controlling the flow of interneurons invading the cortex. Interfering with the regulation of pausing not only affects the size of the cortical interneuron cohort but also impairs the generation of age-matched projection neurons of the upper layers.
['Silva|Carla G|CG|', 'Peyre|Elise|E|', 'Adhikari|Mohit H|MH|', 'Tielens|Sylvia|S|', 'Tanco|Sebastian|S|', 'Van Damme|Petra|P|', 'Magno|Lorenza|L|', 'Krusy|Nathalie|N|', 'Agirman|Gulistan|G|', 'Magiera|Maria M|MM|', 'Kessaris|Nicoletta|N|', 'Malgrange|Brigitte|B|', 'Andrieux|Annie|A|', 'Janke|Carsten|C|', 'Nguyen|Laurent|L|']
D000205:Actomyosin D000818:Animals D002268:Carboxypeptidases D002453:Cell Cycle D002465:Cell Movement D002540:Cerebral Cortex D002630:Chemotactic Factors D004622:Embryo, Mammalian D005260:Female D017353:Gene Deletion D007395:Interneurons D051379:Mice D018345:Mice, Knockout D009024:Morphogenesis D009219:Myosin-Light-Chain Kinase D055495:Neurogenesis D010641:Phenotype
carboxypeptidase MLCK actomyosin corticogenesis cytoskeleton glutamylation neurogenesis