Clinical Correlates and Prognostic Significance of IL-8, sIL-2R, and Immunoglobulin-Free Light Chain Levels in Patients with Myelofibrosis.
BACKGROUND
Chronic myeloproliferative neoplasms are characterized by clonal hematopoiesis and persistent inflammatory reaction. In this study, the clinical significance and prognostic impact of several inflammatory markers were evaluated in patients with BCR/ABL-negative myeloproliferative malignancies.


METHODS
Serum levels of interleukin-8 (IL-8) and lymphoid-associated activation markers - soluble interleukin-2 receptor (sIL-2R) and immunoglobulin-free light chains (FLC) - were evaluated in patients with primary myelofibrosis (MF), post-polycythemia vera MF, and post-essential thrombocythemia MF, and compared with the levels in healthy donors.


RESULTS
In 57 MF patients, sIL-2R excess correlated with transfusion-dependent anemia (p = 0.03) and splenomegaly (p = 0.02). There were no statistically significant correlations between sIL-2R and IL-8 levels, but the plasma concentration of κ-FLC positively correlated with the IL-8 level (p = 0.027). In univariate analysis, increased levels of IL-8 (p = 0.016) and sIL-2R (p = 0.010) significantly reduced 1-year overall survival. Only elevated sIL-2R rate retained significance (p = 0.02) in multivariate analysis when Dynamic International Prognostic Scoring System plus (DIPSSplus) risk stratification was added.


CONCLUSION
We observed an association between FLC and proinflammatory cytokine hyperexpression. Serum cytokine levels and FLC might be a promising approach to predicting and monitoring treatment response in MF patients.
['Barabanshikova|Maria V|MV|', 'Dubina|Irina A|IA|', 'Lapin|Sergey V|SV|', 'Morozova|Elena V|EV|', 'Vlasova|Julia J|JJ|', 'Ivanova|Maria O|MO|', 'Moiseev|Ivan S|IS|', 'Afanasyev|Boris V|BV|']
D000368:Aged D000740:Anemia D005260:Female D006801:Humans D007147:Immunoglobulin Light Chains D007145:Immunoglobulin kappa-Chains D018836:Inflammation Mediators D016209:Interleukin-8 D008297:Male D008875:Middle Aged D011087:Polycythemia Vera D055728:Primary Myelofibrosis D011379:Prognosis D015375:Receptors, Interleukin-2 D012016:Reference Values D013223:Statistics as Topic D016019:Survival Analysis D013920:Thrombocythemia, Essential
Immunoglobulin-free light chains Primary myelofibrosis Cytokines Post-essential thrombocythemia myelofibrosis Post-polycythemia vera myelofibrosis