Quinolidene based monocarbonyl curcumin analogues as promising antimycobacterial agents: Synthesis and molecular docking study.
A series of quinoline incorporated monocarbonyl curcumin analogues was efficiently synthesized using [HDBU][HSO4] as catalyst via Knoevenagel type condensation and evaluated for their in vitro antitubercular activity against Mycobacterium tuberculosis H37Ra (MTB) and Mycobacterium bovis BCG in dormant state. The analogues 3e, 3h, 4a and 4e exhibited very good antitubercular activity. The antiproliferative activity of the analogues against MCF-7, A549 and HCT-116 cell lines was evaluated using modified MTT assay and these compounds were found to be non-cytotoxic. Molecular docking study has been carried out against M. tuberculosis pantothenate synthetase (MTB PS) enzyme in an effort to enhance the understanding of their action as antitubercular agents. The potency, low cytotoxicity and selectivity of these analogues support them as valid leads for further optimization.
['Subhedar|Dnyaneshwar D|DD|', 'Shaikh|Mubarak H|MH|', 'Nawale|Laxman|L|', 'Sarkar|Dhiman|D|', 'Khedkar|Vijay M|VM|', 'Shingate|Bapurao B|BB|']
D000995:Antitubercular Agents D045744:Cell Line, Tumor D003474:Curcumin D004354:Drug Screening Assays, Antitumor D006801:Humans D008826:Microbial Sensitivity Tests D062105:Molecular Docking Simulation D009163:Mycobacterium bovis D009169:Mycobacterium tuberculosis D011804:Quinolines
Molecular docking Antitubercular activity Cytotoxicity Green protocol Knoevenagel condensation