Increased risk of postoperative complications after total thyroidectomy with Graves' disease.
BACKGROUND
The effect of Graves' disease on the risk of postoperative complications in patients undergoing total thyroidectomy is unclear.


METHODS
The incidence of recurrent laryngeal nerve (RLN) injury and hypoparathyroidism were analyzed between 165 patients with Graves' disease (GD group) and 1:1 matched patients with euthyroid states (control group).


RESULTS
The matched cohorts did not differ in age, sex, body mass index, pathologic diagnosis, and extent of operation. Excised thyroid weight was higher in the Graves' disease than in the control group (60.1 g vs 22.6 g; P < .001). Multivariate analysis showed that Graves' disease significantly increased risks of transient RLN injury (odds ratio [OR] = 4.7, 95% confidence interval [CI] = 1.5-15.5; P = .010) and transient hypoparathyroidism (OR = 2.8, 95% CI = 1.3-5.8; P = .007). Rates of permanent complications were comparable in the Graves' disease and control groups.


CONCLUSIONS
Graves' disease can be a predictive factor for postoperative RLN injury and hypoparathyroidism after total thyroidectomy.
['Kwon|Hyungju|H|0000-0003-4979-8749', 'Kim|Jong-Kyu|JK|', 'Lim|Woosung|W|', 'Moon|Byung-In|BI|', 'Paik|Nam Sun|NS|']
D000293:Adolescent D000328:Adult D000368:Aged D016022:Case-Control Studies D005260:Female D006111:Graves Disease D006801:Humans D007011:Hypoparathyroidism D015994:Incidence D008297:Male D008875:Middle Aged D011183:Postoperative Complications D061226:Recurrent Laryngeal Nerve Injuries D013965:Thyroidectomy D055815:Young Adult
complications thyroidectomy Graves' disease hypoparathyroidism RLN injury