Systematic review and meta-analysis on the proportion of patients with breast cancer who develop bone metastases.
A systematic literature review was conducted to quantify populations of patients with primary breast cancer in whom bone metastases were detected at study start or during follow-up. Searches were performed in PubMed and EMBASE using terms related to breast cancer and bone metastases. Articles had to have been published 01/01/99-31/12/13, and to report data on the proportion of patients with bone metastases among patients with breast cancer. In total, 156 articles were included in the meta-analysis. A median of 12% of patients with stage I-III breast cancer developed bone metastases during a median follow-up of 60 months. Of patients who developed metastatic disease during follow-up, 55% (median) had bone metastases. Of those with metastatic breast cancer at study start, 58% (median) had bone metastases. These data help to inform on the global burden of bone metastases by defining patient populations that are at risk of developing bone metastases.
['Body|Jean-Jacques|JJ|', 'Quinn|Geoffrey|G|', 'Talbot|Susan|S|', 'Booth|Emma|E|', 'Demonty|Gaston|G|', 'Taylor|Aliki|A|', 'Amelio|Justyna|J|']
D001859:Bone Neoplasms D001943:Breast Neoplasms D005260:Female D006801:Humans D009367:Neoplasm Staging
Breast cancer Bone metastases Bone metastasis Incidence Prevalence