Study of the Risk and Preventive Factors for Progress of Mild Cognitive Impairment to Dementia.
OBJECTIVE
To evaluate the risk factors for progress of mild cognitive impairment to dementia.


METHODS
This study was based on the epidemiological survey in 2011 (No. PKJ2010-Y26) and contained 441 MCI individuals. Cognitive function was measured by the Mini-Mental Status Examination, clinical dementia rating, and montreal cognitive assessment. The association between demographic characteristics and MCI outcomes were evaluated using single-and multifactor ordered logistic regression analysis models.


RESULTS
Of the 441 MCI, 77 progressed to dementia (MCIp: 17.5%, 95% CI: 14.4%-21.6%), 356 remained stable (MCIs: 80.7%, 95% CI: 77.0%-88.4%), and 8 reverted to normal cognition (MCIr: 1.8%, 95% CI: 0.6%-3.0%) at follow-up in 2017. Univariate ordinal regression analysis showed that diabetes (P = .052), marriage (P = .028), worker (P = .069), and manager (P = .075) may be the risk factor for the status of MCI. Multiple ordinal regression results showed that diabetes (P = .049) and marriage (P = .04) significantly affected the cognitive function changes in the MCI patients.


CONCLUSION
Nondiabetics and being married may prevent the progression from MCI to dementia.
['Hu|Chengping|C|', 'Wang|Ling|L|', 'Guo|Yi|Y|', 'Cao|Zhicheng|Z|', 'Lu|Ying|Y|', 'Qin|Hongyun|H|0000-0001-8751-0908']
D000368:Aged D000369:Aged, 80 and over D060825:Cognitive Dysfunction D003704:Dementia D018450:Disease Progression D005260:Female D006801:Humans D008297:Male D000073216:Mental Status and Dementia Tests D008875:Middle Aged D009483:Neuropsychological Tests D012307:Risk Factors
mild cognitive impairment dementia ordered logistic regression analysis diabetes education past occupation