Molecular mimicry between Larrea divaricata Cav. plant and a reference strain of Pseudomonas aeruginosa.
Currently, the world health sector faces a big problem due to the increase of bacterial strains resistant to antibiotics. In 2017, the World Health Organization reported a list of resistant bacteria, among which Pseudomonas aeruginosa was present. This opportunistic pathogen is associated to nosocomial infections, and no effective vaccines against this bacterium have been found. Larrea divaricata Cav. (jarilla) is a shrub highly distributed in America and widely used in folk medicine. In our laboratory, cross-reactivity of antibodies obtained from the recognition of jarilla proteins against proteins from gram-negative bacteria has been demonstrated. The objective of this study was to study the cross-reactivity of anti-L. divaricata antibodies with P. aeruginosa extracellular proteins in order to find an innocuous prophylactic therapy against this nosocomial pathogen. We observed that antibodies generated by proteins from jarilla crude extract recognized antigenic determinants present in extracellular proteins of P. aeruginosa. However, further studies are needed to investigate the neutralizing capacity of these antibodies on the specific enzymatic proteins involved in the pathogenicity of this bacterium.
['Ferramola|Florencia Fátima|FF|', 'Dávila|Silvia Del Valle|SDV|', 'Sasso|Corina Verónica|CV|', 'Mattar Domínguez|María Aída|MA|']
D000818:Animals D000906:Antibodies D003429:Cross Reactions D004797:Enzyme-Linked Immunosorbent Assay D056724:Immunity, Humoral D007074:Immunoglobulin G D032442:Larrea D051379:Mice D018716:Molecular Mimicry D010936:Plant Extracts D010940:Plant Proteins D011550:Pseudomonas aeruginosa
Larrea divaricata Pseudomonas aeruginosa Cross-reactivity Aqueous extract Ismmunogenic proteins