When are the BET factors the most sensitive to bromodomain inhibitors?
The recent publication of two detailed studies of mouse spermatogenesis, either after chemical inhibition of the BET bromodomains, or in the context of genetic alterations of one specific BET member, Brdt, provides the unique opportunity to assess the functional impact of BET bromodomain inhibitors.
['Khochbin|Saadi|S|']
D000818:Animals D001381:Azepines D002868:Chromosomal Proteins, Non-Histone D005786:Gene Expression Regulation D008297:Male D051379:Mice D009419:Nerve Tissue Proteins D009687:Nuclear Proteins D017346:Protein Serine-Threonine Kinases D011956:Receptors, Cell Surface D013091:Spermatogenesis D014157:Transcription Factors D014230:Triazoles
spermatogenesis Brdt Brd2 Brd3 Brd4 acetylation cancer chromatin histone infertility pTEFb