Patterned high-frequency stimulation induces a form of long-term depression dependent on GABAA and mACh receptors in the hippocampus.
Certain patterns of neural activity can induce N-methyl-D-aspartic acid receptor (NMDAR)-dependent synaptic plasticity, one of the important foundations of memory. Here, we report that a patterned high-frequency stimulation (PHS) induces rat hippocampal long-term depression (LTD) in an NMDAR-independent manner that requires coactivation of GABA(A)Rs and muscarinic acetylcholine receptors (mAChRs), and endocytosis of AMPARs. Thus, we disclose that a patterned high-frequency stimulation triggers GABAAR and mAChR-dependent LTD in the hippocampus.
['Zhu|Y-Y|YY|', 'Jing|L|L|', 'Duan|T-T|TT|', 'Yuan|Q|Q|', 'Cao|J|J|', 'Zhou|Q-X|QX|', 'Xu|L|L|']
D015763:2-Amino-5-phosphonovalerate D000818:Animals D000841:Anisomycin D001565:Benzoates D056547:CA1 Region, Hippocampal D004558:Electric Stimulation D055724:Electrophysiological Phenomena D018691:Excitatory Amino Acid Antagonists D019706:Excitatory Postsynaptic Potentials D018756:GABA Antagonists D005998:Glycine D006624:Hippocampus D017774:Long-Term Potentiation D008297:Male D009473:Neuronal Plasticity D011500:Protein Synthesis Inhibitors D051381:Rats D017207:Rats, Sprague-Dawley D011950:Receptors, Cholinergic D011963:Receptors, GABA-A
patterned high-frequency stimulation high-frequency stimulation stimulation long-term depression mACh receptors N-methyl-d-aspartic acid receptor PHS LTD muscarinic acetylcholine receptor acetylcholine mAChR (RS)-α-methyl-4-carboxyphenylglycine ACSF ACh Atrp BIC D-AP5 DMSO GABA(A) receptors HFS IBI LFS LTP MCPG NMDAR PTX Scopo Sti TBS artificial cerebrospinal fluid atropine bicuculline d-(−)-2-amino-5-phosphonopentanoic acid dimethyl sulfoxide fEPSPs field excitatory postsynaptic potentials hippocampal CA1 inter-burst interval long-term potentiation low-frequency stimulation mGluR metabotropic glutamate receptor picrotoxin scopolamine theta burst stimulation