Inferring Functional Relationships from Conservation of Gene Order.
Predicting functional associations using the Gene Neighbor Method depends on the simple idea that if genes are conserved next to each other in evolutionarily distant prokaryotes they might belong to a polycistronic transcription unit. The procedure presented in this chapter starts with the organization of the genes within genomes into pairs of adjacent genes. Then, the pairs of adjacent genes in a genome of interest are mapped to their corresponding orthologs in other, informative, genomes. The final step is to verify if the mapped orthologs are also pairs of adjacent genes in the informative genomes.
['Moreno-Hagelsieb|Gabriel|G|']
D019295:Computational Biology D017124:Conserved Sequence D019143:Evolution, Molecular D023061:Gene Order D020745:Genome, Archaeal D016680:Genome, Bacterial
Conservation of gene order Gene neighbor method Functional inference Genomic context Operon