FDG PET/CT imaging features and clinical utility in COVID-19.
PURPOSE
To determine the imaging findings and potential clinical utility of FDG PET/CT in patients with laboratory-confirmed COVID-19.


METHODS
We performed a single institution retrospective review of patients diagnosed with COVID-19 using real time reverse transcription-polymerase chain reaction (RT-PCR) who underwent FDG PET/CT for routine cancer care between March 1, 2020 to April 30, 2020, during the height of the pandemic in New York City, New York, United States. PET/CT scans were retrospectively reviewed for imaging findings suspicious for COVID-19. For positive scans, PET and CT findings were recorded, including location, FDG avidity (SUVmax) and CT morphology. Patient demographics and COVID-19 specific clinical data were collected and analyzed with respect to PET/CT scan positivity, lung SUVmax, and time interval between PET/CT and RT-PCR.


RESULTS
Thirty-one patients (21 males and 10 females, mean age 57 years ± 16) were evaluated. Thirteen of 31 patients had positive PET/CT scans, yielding a detection rate of 41.9%. Patients with positive scans had significantly higher rates of symptomatic COVID-19 infection (77% vs 28%, p = 0.01) and hospitalizations (46% vs. 0%, p = 0.002) compared to patients with negative scans. Eleven of 13 patients (84.6%) with positive scans had FDG-avid lung findings, with mean lung SUVmax of 5.36. Six of 13 patients (46.2%) had extrapulmonary findings of FDG-avid thoracic lymph nodes. The detection rate was significantly lower when the scan was performed before RT-PCR versus after RT-PCR (18.8% (n = 3/16) vs. 66.7% (n = 10/15), p = 0.009). Lung SUVmax was not associated with COVID-19 symptoms, severity, or disease course.


CONCLUSION
FDG PET/CT has limited sensitivity for detecting COVID-19 infection. However, a positive PET scan is associated with higher risk of symptomatic infection and hospitalizations, which may be helpful in predicting disease severity.
['Yeh|Randy|R|', 'Elsakka|Ahmed|A|', 'Wray|Rick|R|', 'Johnston|Rocio Perez|RP|', 'Gangai|Natalie C|NC|', 'Yarmohammadi|Hooman|H|', 'Schoder|Heiko|H|', 'Pandit-Taskar|Neeta|N|']
D000086382:COVID-19 D005260:Female D019788:Fluorodeoxyglucose F18 D006801:Humans D008297:Male D008875:Middle Aged D009519:New York City D000072078:Positron Emission Tomography Computed Tomography D049268:Positron-Emission Tomography D019275:Radiopharmaceuticals D012189:Retrospective Studies D000086402:SARS-CoV-2
FDG PET PET/CT Covid-19 Coronavirus disease 2019