The FinO family of bacterial RNA chaperones.
Antisense RNAs have long been known to regulate diverse aspects of plasmid biology. Here we review the FinOP system that modulates F plasmid gene expression through regulation of the F plasmid transcription factor, TraJ. FinOP is a two component system composed of an antisense RNA, FinP, which represses TraJ translation, and a protein, FinO, which is required to stabilize FinP and facilitate its interactions with its traJ mRNA target. We review the evidence that FinO acts as an RNA chaperone to bind and destabilize internal stem-loop structures within the individual RNAs that would otherwise block intermolecular RNA duplexing. Recent structural studies have provided mechanistic insights into how FinO may facilitate interactions between FinP and traJ mRNA. We also review recent findings that two other proteins, Escherichia coli ProQ and Neisseria meningitidis NMB1681, may represent FinO-like RNA chaperones.
['Mark Glover|J N|JN|', 'Chaulk|Steven G|SG|', 'Edwards|Ross A|RA|', 'Arthur|David|D|', 'Lu|Jun|J|', 'Frost|Laura S|LS|']
D001425:Bacterial Outer Membrane Proteins D029968:Escherichia coli Proteins D005144:F Factor D005786:Gene Expression Regulation D026901:Membrane Transport Proteins D018832:Molecular Chaperones D009345:Neisseria meningitidis D009690:Nucleic Acid Conformation D016372:RNA, Antisense D012329:RNA, Bacterial D012333:RNA, Messenger D016601:RNA-Binding Proteins D012097:Repressor Proteins
FinO RNA chaperone Antisense RNA FinP Plasmid conjugation