Role of Inflammatory Diseases in Hypertension.
Chronic inflammatory diseases (CID) are characterized by an increased risk of cardiovascular (CV) morbidity and mortality. Several mechanisms, including early acceleration of subclinical atherosclerotic damage, inflammatory markers and immune system deregulation factors, have been demonstrated to strictly interplay for development and progression of atherosclerosis. Moreover, traditional CV risk factors are likely to explain at least some of the excess of CV risk in these patients. Among traditional CV risk factors, compelling evidence suggests a higher incidence and prevalence of hypertension in patients with CID in comparison to the general population. Moreover, hypertension represents an important predictor of CV events in these patients. Pathogenic mechanisms underlying the rise of blood pressure in CID are multifactorial and still poorly investigated. Indeed, multiple disease-related factors may affect blood pressure control in these patients and hypertension may affect disease prognosis and increase CV risk. Better knowledge of the complex interplay between hypertension and CID will be important to elucidate pathogenic mechanisms and to improve CV outcome in these patients. Aim of this review is to highlight available evidence on the relationship between hypertension and CID and to elucidate the multiple factors that may affect blood pressure control in these disorders.
['Bartoloni|E|E|', 'Alunno|A|A|', 'Valentini|V|V|', 'Luccioli|F|F|', 'Valentini|E|E|', 'La Paglia|G|G|', 'Bistoni|O|O|', 'Gerli|Roberto|R|']
D000328:Adult D000368:Aged D001794:Blood Pressure D002908:Chronic Disease D005260:Female D006801:Humans D006973:Hypertension D015994:Incidence D007249:Inflammation D018836:Inflammation Mediators D008297:Male D008875:Middle Aged D015995:Prevalence D011379:Prognosis D018570:Risk Assessment D012307:Risk Factors D015398:Signal Transduction
Hypertension Chronic inflammatory diseases Cardiovascular risk