Glucagon Control on Food Intake and Energy Balance.
Glucagon exerts pleiotropic actions on energy balance and has emerged as an attractive target for the treatment of diabetes and obesity in the last few years. Glucagon reduces body weight and adiposity by suppression of appetite and by modulation of lipid metabolism. Moreover, this hormone promotes weight loss by activation of energy expenditure and thermogenesis. In this review, we cover these metabolic actions elicited by glucagon beyond its canonical regulation of glucose metabolism. In addition, we discuss recent developments of therapeutic approaches in the treatment of obesity and diabetes by dual- and tri-agonist molecules based on combinations of glucagon with other peptides. New strategies using these unimolecular polyagonists targeting the glucagon receptor (GCGR), have become successful approaches to evaluate the multifaceted nature of glucagon signaling in energy balance and metabolic syndrome.
['Al-Massadi|Omar|O|0000-0003-0645-6159', 'Fernø|Johan|J|', 'Diéguez|Carlos|C|', 'Nogueiras|Ruben|R|', 'Quiñones|Mar|M|0000-0003-0180-2147']
D000818:Animals D019440:Anti-Obesity Agents D001069:Appetite Regulation D001835:Body Weight D003920:Diabetes Mellitus D004734:Energy Metabolism D005934:Glucagon D005947:Glucose D006801:Humans D007004:Hypoglycemic Agents D050356:Lipid Metabolism D058990:Molecular Targeted Therapy D009765:Obesity D010455:Peptides D018027:Receptors, Glucagon D022722:Thermogenesis
glucagon food intake energy balance obesity body weight lipid metabolism energy expenditure thermogenesis