A Reactive Oxygen Species (ROS) Activated Hydrogen Sulfide (H2S) Donor with Self-Reporting Fluorescence.
Hydrogen sulfide (H2S) is an important cellular signaling molecule, and its physiological and pathophysiological properties have been under intensive investigation. In this study, a novel ratiometric fluorescent H2S donor (HSD-B) has been developed, which exhibited the following advantages: (i) scavenging ROS and producing H2S simultaneously; (ii) providing ratiometric fluorescence for visualization and quantification of H2S releasing; and (iii) targeting mitochondrion specifically. Moreover, it demonstrated protective effects on myocardial ischemia reperfusion injury in a cellular model. These attractive features promise this HSD-B as a fluorescent H2S donor for future research studies.
['Zhang|Ning|N|', 'Hu|Ping|P|', 'Wang|Yanfang|Y|', 'Tang|Qing|Q|', 'Zheng|Qiang|Q|', 'Wang|Zhanlong|Z|', 'He|Yun|Y|0000-0002-5322-7300']
D005453:Fluorescence D006801:Humans D006862:Hydrogen Sulfide D017382:Reactive Oxygen Species D014019:Tissue Donors
reactive oxygen species self-reporting fluorescence ratiometric fluorescence myocardial ischemia reperfusion injury hydrogen sulfide donor