Guanidinoacetic Acid and Creatine are Associated with Cardiometabolic Risk Factors in Healthy Men and Women: A Cross-Sectional Study.
Guanidinoacetic acid (GAA) conversion to creatine is thought to be involved in cardiometabolic disturbances through its role in biological methylation and insulin secretion. We evaluated the association of serum GAA and creatine with cardiometabolic risk factors in a cohort of 151 apparently healthy adults (82 women and 69 men) aged 18-63 years. Serum levels of GAA and creatine were measured with liquid chromatography-tandem mass spectrometry. A multiple linear regression model adjusted for age and sex was employed to examine the relationship of serum GAA and creatine with cardiometabolic risk factors. Higher GAA levels were associated with an unfavorable cardiometabolic risk profile (higher insulin, higher total homocysteine, and higher body fat percentage), while having elevated serum creatine levels (≥31.1 µmol/L) was associated with being overweight (body mass index ≥ 25.0 kg/m). The results from our study suggest a possible role of the GAA-creatine axis in the pathogenesis of cardiovascular and metabolic diseases.
['Ostojic|Sergej M|SM|0000-0002-7270-2541', 'Vranes|Milan|M|', 'Loncar|Davor|D|', 'Zenic|Natasa|N|', 'Sekulic|Damir|D|0000-0001-8022-7886']
D000293:Adolescent D000328:Adult D015992:Body Mass Index D002097:C-Reactive Protein D002318:Cardiovascular Diseases D002784:Cholesterol D002853:Chromatography, Liquid D015331:Cohort Studies D003401:Creatine D003430:Cross-Sectional Studies D005260:Female D005998:Glycine D006801:Humans D007328:Insulin D000078790:Insulin Secretion D008297:Male D008659:Metabolic Diseases D008875:Middle Aged D050177:Overweight D012307:Risk Factors D053719:Tandem Mass Spectrometry D014280:Triglycerides D055815:Young Adult
guanidinoacetic acid creatine cardiometabolic risk homocysteine overweight