Protective effects of protocatechuic acid against cognitive impairment in an amyloid beta-induced Alzheimer's disease mouse model.
In this study, we investigated the protective effects of protocatechuic acid (PA) against cognitive impairment in an amyloid-beta (Aβ)-induced Alzheimer's disease (AD) mouse model. PA was administered orally for 14 days at 100 and 200 mg/kg/day. To examine effects on cognition, we conducted behavior tests including the T-maze test, novel object recognition, and the Morris water maze test. In addition, we measured lipid peroxidation, nitric oxide (NO) production, and inflammation-related protein expression in mice tissues. The PA-administered group showed more use of novel routes, better novel object recognition, and learning and memory ability compared to the Aβ25-35-injected mice in the behavior tests. The results indicated that the administration of higher PA protected against cognitive impairment. In addition, the PA-administered groups showed significantly decreased lipid peroxidation and NO production in the brain, kidney, and liver tissues. Furthermore, the PA-administered groups showed attenuated Aβ25-35-induced neuroinflammation by downregulating inflammatory mediators, inducible nitric oxide synthase and cyclooxygenase-2 in the brain. The results of the present study suggest that PA may be a protective agent against AD.
['Choi|Jung Ran|JR|', 'Kim|Ji Hyun|JH|', 'Lee|Sanghyun|S|', 'Cho|Eun Ju|EJ|', 'Kim|Hyun Young|HY|']
D000544:Alzheimer Disease D016229:Amyloid beta-Peptides D000818:Animals D003072:Cognition Disorders D004195:Disease Models, Animal D006801:Humans D062385:Hydroxybenzoates D018836:Inflammation Mediators D015227:Lipid Peroxidation D008297:Male D018782:Maze Learning D051379:Mice D008813:Mice, Inbred ICR D009569:Nitric Oxide D018384:Oxidative Stress
Protocatechuic acid Alzheimer's disease Amyloid-beta Neuroinflammation Oxidative stress