The regulatory roles of ROCK and MRCK kinases in the plasticity of cancer cell migration.
Metastatic cancer cells show great plasticity in their migratory mechanisms. In this review we briefly describe the signal transduction pathways associated with the ROCK and MRCK kinases and their roles in cancer cell migration and in its plasticity. With respect to therapeutic strategies targeting metastatic cancers, selectively blocking a single target, such as ROCK or MRCK, can induce alternate modes of cancer cell migration (i.e. plasticity) making the treatment ineffective. To address the problem of plasticity, we will discuss the strategy of simultaneous targeting of both ROCK and MRCK as an effective anti-metastatic therapeutics.
['Kale|Vijay Pralhad|VP|', 'Hengst|Jeremy A|JA|', 'Desai|Dhimant H|DH|', 'Amin|Shantu G|SG|', 'Yun|Jong K|JK|']
D002465:Cell Movement D006801:Humans D009369:Neoplasms D017346:Protein Serine-Threonine Kinases D015398:Signal Transduction D054460:rho-Associated Kinases
MRCK Anticancer therapeutics Cell migration plasticity Polypharmacology ROCK and MRCK inhibitors Rho kinase