Retrospective review of genomic testing in breast cancer: Does it improve outcome?
PURPOSE
Tumor genomic testing has become widely available in many clinical settings. However, we do not yet understand how to best harness the information yielded from this testing. We retrospectively investigated the clinical courses of 24 patients who underwent tumor genomic testing to determine whether targeted therapy is associated with improved progression free survival (PFS) compared to standard therapy.


METHODS
The patient population comprised metastatic breast cancer patients who underwent tumor genomic testing (testing biopsy specimens of primary or metastatic lesions for 50 commonly mutated genes) at our institution between September 1, 2010 and June 1, 2015. Through retrospective chart review, we compared PFS for those patients who received targeted therapy based on their genomic testing results, and those who did not.


RESULTS
The median PFS was 5.7 months for those who received targeted therapy versus 5.4 months for those who did not (p = 0.6). There was no statistically significant difference in PFS between the two groups.


CONCLUSIONS
In this relatively small group, the PFS was markedly similar between the targeted therapy and standard therapy groups. Currently, there is no clear evidence to incorporate tumor genomic testing into routine clinical practice.
['Gastelum|Grady M|GM|', 'Iqbal|Cyrus|C|', 'Hilsenbeck|Susan G|SG|', 'Rimawi|Mothaffar F|MF|', 'Niravath|Polly|P|']
D000328:Adult D000368:Aged D001943:Breast Neoplasms D018572:Disease-Free Survival D005260:Female D005820:Genetic Testing D023281:Genomics D006801:Humans D053208:Kaplan-Meier Estimate D008875:Middle Aged D058990:Molecular Targeted Therapy D009154:Mutation D012189:Retrospective Studies D016896:Treatment Outcome
Genomic testing Breast cancer Targeted therapy Progression-free survival