Association of rs780094 polymorphism of glucokinase regulatory protein with non-alcoholic fatty liver disease.
OBJECTIVE
GCK rs780094 polymorphism is a single nucleotide polymorphism that has been associated with obesity, type II diabetes and dyslipidemia in some populations, conditions that highly related to NAFL etiology. The present study aimed to evaluate the relationship between NAFLD and rs780094 polymorphism in patients with NAFLD in Tabriz city, northwest of Iran. The rs780094 polymorphism was determined in 74 patients with NAFLD by PCR-RFLP technique. Demographic information was collected using a questionnaire and biochemical analysis was performed using standard laboratory methods.


RESULTS
There was a significant difference between case and control subjects for alanine aminotransferase, aspartate aminotransferase, HDL-C and triglycerides (P < 0.05). Analysis by PCR-RFLP method revealed that there were no significant differences between NAFLD and healthy subjects for rs780094 polymorphism in the study population. The results of this study indicated that rs780094 polymorphism is not associated with NAFLD in subjects from Tabriz city.
['Mohammadi|Saba|S|', 'Farajnia|Safar|S|http://orcid.org/0000-0002-6087-9147', 'Shadmand|Masoud|M|', 'Mohseni|Fatemeh|F|', 'Baghban|Roghayyeh|R|']
D000328:Adult D000483:Alleles D002352:Carrier Proteins D005260:Female D005787:Gene Frequency D020022:Genetic Predisposition to Disease D006801:Humans D008297:Male D008875:Middle Aged D065626:Non-alcoholic Fatty Liver Disease D020641:Polymorphism, Single Nucleotide D055815:Young Adult
rs780094 polymorphism NAFLD Biochemical parameters Demographic parameters