TPL2 kinase action and control of inflammation.
Tumor progression locus 2 (TPL2, also known as COT or MAP3K8) is a mitogen-activated protein kinase kinase (MAP3K) activated downstream of TNFαR, IL1R, TLR, CD40, IL17R, and some GPCRs. TPL2 regulates the MEK1/2 and ERK1/2 pathways to regulate a cascade of inflammatory responses. In parallel to this, TPL2 also activates p38α and p38δ to drive the production of various inflammatory mediators in neutrophils. We discuss the implications of this finding in the context of various inflammatory diseases.
['Xu|Daqi|D|', 'Matsumoto|Marissa L|ML|', 'McKenzie|Brent S|BS|', 'Zarrin|Ali A|AA|']
D000818:Animals D015551:Autoimmunity D006801:Humans D007249:Inflammation D020930:MAP Kinase Kinase Kinases D011518:Proto-Oncogene Proteins
TPL2 Inflammation COT MAP3K8 TLRs Neutrophil Autoimmune disease COPD ERK IBD MAPK Macrophage Multiple sclerosis Phosphorylation Psoriasis Rheumatoid arthritis TNFα p38