Effect of Differently Fed Farmed Gilthead Sea Bream Consumption on Platelet Aggregation and Circulating Haemostatic Markers among Apparently Healthy Adults: A Double-Blind Randomized Crossover Trial.
Fish consumption beneficially affects coagulation markers. Few dietary intervention studies have investigated differently fed farmed fish against these cardio-metabolic risk factors in humans. This double-blind randomized crossover trial evaluated differently fed farmed gilthead sea bream consumption against platelet aggregation and circulating haemostatic markers among apparently healthy adults. Subjects aged 30-65 years, with a body mass index 24.0-31.0 kg/m2, consuming less than 150 g cooked fish per week, were recruited in Attica, Greece. Participants were randomized (n = 38, 1:1) to one of two sequences; consumption of fish fed with fish oil diet (conventional fish, CF)/fish fed with olive pomace-enriched diet (enriched fish, EF) versus EF/CF. The primary outcomes were ex vivo human platelet aggregation and circulating plasminogen activator inhibitor-1 (PAI-1) and P-selectin (sP-selectin) concentrations. EF consumption had no significant effect on platelet sensitivity or haemostatic markers compared to CF. Platelet sensitivity to platelet-activating factor (PAF) decreased after CF consumption during the second period (p < 0.01). Plasma PAI-1 and sP-selectin concentrations increased after CF consumption during both periods (p < 0.01 for both). Based on current findings, consumption of enriched farmed gilthead sea bream had no greater effect on coagulation markers in adults compared to the conventionally fed fish.
['Ntzouvani|Agathi|A|', 'Antonopoulou|Smaragdi|S|0000-0002-7071-5920', 'Fragopoulou|Elizabeth|E|', 'Kontogianni|Meropi D|MD|0000-0003-3168-8867', 'Nomikos|Tzortzis|T|0000-0003-0536-6397', 'Mikellidi|Anastasia|A|', 'Xanthopoulou|Μarianna|Μ|', 'Kalogeropoulos|Nick|N|0000-0002-9346-4933', 'Panagiotakos|Demosthenes|D|0000-0001-8583-153X']
D000328:Adult D000368:Aged D000821:Animal Feed D000818:Animals D015415:Biomarkers D001777:Blood Coagulation D018592:Cross-Over Studies D004032:Diet D004311:Double-Blind Method D005395:Fish Oils D005398:Fisheries D006487:Hemostasis D006801:Humans D008875:Middle Aged D010974:Platelet Aggregation D021541:Sea Bream D017747:Seafood
fish human platelet aggregation PAI-1 sP-selectin PAF ADP olive pomace thrombin