Oral Pharmacologic Management of Overactive Bladder Syndrome: Where Do We Stand?
Overactive bladder syndrome (OAB) is a prevalent disorder with a significant impact on quality of life. Despite this high prevalence, there is significant underdiagnosis and undertreatment due to several barriers, including embarrassment, poor communication and low patient adherence. Currently, various antimuscarinic are available in the treatment of OAB. The introduction of mirabegron has broadened the therapeutic approach and combination therapy of both agents can be valuable in clinical practice. Yet, patient adherence to most drugs for OAB is still relatively poor. Healthcare providers need to identify and utilise strategies to improve treatment adherence by defining clear treatment goals, implement educational methods and frequently communicate with patients to identify problems with adherence. The elderly population form need special attention as in these patients, anticholinergics should be prescribed with care and adequate knowledge regarding pharmacokinetics and drug interactions in essential. Furthermore, patient expectations should be clearly discussed. In this narrative review, the current advances in oral pharmacotherapy are evaluated and the most important factors involved in the management of OAB are discussed.
['Marcelissen|Tom|T|', 'Rashid|Tina|T|', 'Antunes Lopes|Tiago|T|', 'Delongchamps|Nicolas Barry|NB|', 'Geavlete|Bogdan|B|', 'Rieken|Malte|M|', 'Cornu|Jean-Nicolas|JN|', "Rahnama'i|Mohammad Sajjad|MS|", '|||']
D000083:Acetanilides D000284:Administration, Oral D058667:Adrenergic beta-3 Receptor Agonists D000368:Aged D016022:Case-Control Studies D018680:Cholinergic Antagonists D004359:Drug Therapy, Combination D005260:Female D006801:Humans D008297:Male D008333:Mandelic Acids D008875:Middle Aged D018727:Muscarinic Antagonists D010349:Patient Compliance D015995:Prevalence D011788:Quality of Life D013844:Thiazoles D053201:Urinary Bladder, Overactive
Pharmacology Overactive bladder syndrome Drug Incontinence Medication Urgency