Arterial hemodynamics are impaired at rest and following acute exercise in overweight young men.
Higher body mass index (BMI) is associated with greater cardiovascular disease (CVD) risk, in part due to aortic stiffening assessed by carotid-femoral pulse wave velocity (cfPWV). Importantly, greater cardiorespiratory fitness (CRF; VO2peak) decreases CVD risk, and is associated with reductions in aortic stiffness. We tested the hypothesis that young adult overweight (OW, n=17) compared with healthy-weight (HW, n=17) men will have greater resting aortic stiffness, reduced CRF and an impaired post-exercise hemodynamic response. Resting cfPWV was greater in OW versus HW individuals (5.81 ± 0.13 vs 4.81 ± 0.12 m/sec, p<0.05). Relative CRF (VO2peak; mL/kg/min) was lower in OW compared with HW individuals (49.4 ± 1.3 vs 57.6 ± 1.0 mL/kg/min, p<0.05), and was inversely related with cfPWV (p<0.05). However, CRF as absolute VO2peak (L/min) was not different between groups and there was no relation between cfPWV and absolute VO2peak (L/min), indicating reduced relative CRF in OW men is due to greater body mass. Following the maximal treadmill exercise test, cfPWV was greater in OW compared with HW subjects from rest to 60 minutes post-exercise (p<0.05). Compared with HW, OW individuals had higher systolic blood pressure (main effect, p<0.05) and diastolic blood pressure was selectively increased for up to 60 minutes following exercise (p<0.05). Overweight individuals had an attenuated post-exercise decrease in mean arterial pressure (p<0.05). Collectively, these results indicate that young, apparently healthy, OW men have greater resting aortic stiffening and an impaired post-exercise hemodynamic response.
['Moore|Stephanie M|SM|', 'Berrones|Adam J|AJ|', 'Clasey|Jody L|JL|', 'Abel|Mark G|MG|', 'Fleenor|Bradley S|BS|']
D000293:Adolescent D000328:Adult D062186:Arterial Pressure D015992:Body Mass Index D000072599:Cardiorespiratory Fitness D002318:Cardiovascular Diseases D015444:Exercise D005080:Exercise Test D006439:Hemodynamics D006801:Humans D008297:Male D050177:Overweight D010101:Oxygen Consumption D063177:Pulse Wave Analysis D012146:Rest D013997:Time Factors D059289:Vascular Stiffness D055815:Young Adult
exercise overweight pulse wave velocity aortic stiffness