Identification of a Unique Azaphilone Produced by Chaetomium globosum Isolated from Polygonatum sibiricum.
A new azaphilone, chaephilone E, eight azaphilone derivatives, and three chaetoglobosins were isolated from endophytic fungi Chaetomium globosum. The structures of the compounds were elucidated by 1D and 2D NMR as well as HR-ESI-MS data, and the absolute configuration of chaephilone E was established on the basis of electronic circular dichroism and NOESY spectrum. The activity of chaephilone E was evaluated via the cytotoxic assay (human hepatoma cell lines HepG-2) and brine shrimp (Artemia salina) bioassay.
['Song|Chenggang|C|', 'Ding|Gang|G|', 'Wu|Gang|G|', 'Yang|Jian|J|', 'Zhang|Mingzhe|M|', 'Wang|Haoyu|H|', 'Wei|Dongsheng|D|', 'Qin|Jianchun|J|http://orcid.org/0000-0002-5903-2272', 'Guo|Lanping|L|']
D000818:Animals D000972:Antineoplastic Agents, Phytogenic D001156:Artemia D001578:Benzopyrans D049109:Cell Proliferation D002597:Chaetomium D004305:Dose-Response Relationship, Drug D004354:Drug Screening Assays, Antitumor D056945:Hep G2 Cells D006801:Humans D015394:Molecular Structure D010860:Pigments, Biological D031384:Polygonatum D013329:Structure-Activity Relationship
azaphilone Chaetomium globosum Polygonatum sibiricum cytotoxicity structure identification