microRNA-30a attenuates TGF-β1-induced activation of pulmonary fibroblast cell by targeting FAP-α.
Idiopathic interstitial pulmonary fibrosis is a common diffuse interstitial lung disease and has poor prognosis. And one of the pathological features of it is persistent fibroblast activation. It was reported that microRNA-30a was down-regulated in bronchoalveolar lavage fluid from idiopathic pulmonary fibrosis patients. But whether miR-30a is involved in fibroblast activation and its specific mechanism is unclear. In this study, we aimed to investigate the role of miR-30a in fibroblast activation induced by TGF-β1. We found miR-30a could targetedly suppress FAP-α expression. In MRC5 cells, miR-30a was not only involved in regulating the expression of FAP-α, col1a and α-SMA induced by TGF-β1 but also had a role in cell proliferation with or without TGF-β1 treatment via regulating FAP-α expression. Thus, the results indicated that miR-30a alleviated fibroblast activation by regulating the expression of FAP-α.
['Wu|Geting|G|', 'Xie|Bin|B|', 'Lu|Can|C|', 'Chen|Chen|C|', 'Zhou|Jianhua|J|', 'Deng|Zhenghao|Z|0000-0002-2325-1246']
D001483:Base Sequence D002460:Cell Line D010450:Endopeptidases D005347:Fibroblasts D006801:Humans D008168:Lung D008565:Membrane Proteins D035683:MicroRNAs D053773:Transforming Growth Factor beta1
FAP-α pulmonary fibrosis miR-30a TGF-β1 MRC5