TRIM23 overexpression is a poor prognostic factor and contributes to carcinogenesis in colorectal cancer.
The tripartite motif (TRIM) family proteins play a great role in carcinogenesis. However, the expression pattern, prognostic value and biological functions of tripartite motif containing 23 (TRIM23) in colorectal cancer (CRC) are poorly understood. Here, we found that TRIM23 is up-regulated and associated with tumour size, lymph node metastasis, American Joint Committee on Cancer (AJCC) stage and poor prognosis in CRC. Multivariate Cox regression analyses revealed that TRIM23 overexpression could be identified as an independent prognostic factor for CRC. TRIM23 could promote the proliferation of CRC cell in vitro and in vivo; additionally, TRIM23 depletion induced G1-phase arrest. Gene set enrichment analysis (GSEA) revealed that P53 and cell cycle signalling pathway-related genes were enriched in patients with high TRIM23 expression levels. We show in this study that TRIM23 physically binds to P53 and enhances the ubiquitination of P53, thereby promoting tumour proliferation. Thus, our data indicated that TRIM23 acts as an oncogene in colorectal carcinogenesis and may provide a novel therapeutic target for CRC management.
['Han|Yudong|Y|', 'Tan|Ye|Y|', 'Zhao|Yuanyuan|Y|', 'Zhang|Yongchun|Y|', 'He|Xinjia|X|', 'Yu|Li|L|', 'Jiang|Haiping|H|', 'Lu|Haijun|H|', 'Tian|Haiying|H|0000-0002-4538-981X']
D000368:Aged D000818:Animals D014408:Biomarkers, Tumor D045744:Cell Line, Tumor D002465:Cell Movement D002470:Cell Survival D002471:Cell Transformation, Neoplastic D015179:Colorectal Neoplasms D004195:Disease Models, Animal D004198:Disease Susceptibility D005260:Female D059585:G1 Phase Cell Cycle Checkpoints D019204:GTP-Binding Proteins D015870:Gene Expression D015972:Gene Expression Regulation, Neoplastic D064593:Heterografts D006801:Humans D007150:Immunohistochemistry D008297:Male D051379:Mice D008875:Middle Aged D009362:Neoplasm Metastasis D009367:Neoplasm Staging D011379:Prognosis D015398:Signal Transduction D016159:Tumor Suppressor Protein p53
TRIM23 colorectal cancer proliferation P53 cell cycle