Myocardial Performance Index Determined by Tissue Doppler Imaging in Patients With Systolic Heart Failure Predicts Poor Long-Term Prognosis: An Observational Cohort Study.
BACKGROUND
Myocardial performance index (MPI) is an echocardiographic parameter that reflects left ventricular (LV) function. MPI determined by means of tissue Doppler imaging (TDI) at different LV sites (global MPI) and its long-term prognostic implications in congestive heart failure (HF) have not been evaluated.


METHODS AND RESULTS
A total of 110 patients with HF during acute hospitalization were followed for a mean of 5.0 years for survivors. The myocardial velocities at 4 different LV sites near the mitral annulus from apical views were recorded with the use of pulsed-wave TDI. From myocardial velocity profiles, the MPI at each LV site was calculated: MPI = (isovolumetric contraction time + isovolumetric relaxation time)/ejection time. The global MPI was calculated as the mean from the 4 LV sites. Mean ejection fraction was 25%. A total of 61 patients died during the study period. On multivariate analysis, only MPI emerged as an independent predictor of mortality. With a cutoff value of 0.67, the hazard ratio for cardiovascular mortality during the follow-up period was 13 (95% confidence interval 5.03-34.44; P < .001). A cutoff MPI value of ≥0.67 identified patient mortality during the study period with a sensitivity of 86% and a specificity of 79%.


CONCLUSION
Global TDI-derived MPI in patients with HF is a powerful predictor of cardiovascular mortality in patients with systolic HF.
['Olson|Jens M|JM|', 'Samad|Bassem A|BA|', 'Alam|Mahbubul|M|']
D000368:Aged D015150:Echocardiography, Doppler D005260:Female D005500:Follow-Up Studies D054143:Heart Failure, Systolic D006352:Heart Ventricles D006801:Humans D008297:Male D011379:Prognosis D012307:Risk Factors D013318:Stroke Volume D015996:Survival Rate D013997:Time Factors D016277:Ventricular Function, Left
Myocardial performance index prognosis congestive heart failure