Guidewire fracture during orbital atherectomy for peripheral artery disease: Insights from the Manufacturer and User Facility Device Experience database.
BACKGROUND/OBJECTIVES
Orbital atherectomy (OA) is routinely being used for plaque modification to facilitate percutaneous revascularization in patients with peripheral arterial disease (PAD) and arterial calcification. Guidewire fracture (GWF) during OA, though anecdotally described, has not been studied in a systematic manner. We conducted a review of the Manufacturer and User Facility Device Experience (MAUDE) database to study the reports of wire fracture and its management and consequences.


METHODS
We queried the MAUDE database for all events involving the current generation of the OA device: "Diamondback 360 Peripheral Orbital Atherectomy System", and "Stealth 360° Orbital PAD System".


RESULTS
We identified 62 reports of GWF during OA for PAD. The superficial femoral artery was the most commonly involved atherectomy site. The wire fractured at the soft tip in a majority of cases (68%). Embolized wire fragments were left in the patient in 36 cases (58%), retrieved percutaneously in 10 cases (16%), and trapped by a stent against the arterial wall in eight cases (13%). Lastly, eight patients (13%) underwent surgery for removal of the wire fragment.


CONCLUSIONS
This is the first published report to study the complication of GWF during peripheral OA. GWF is an uncommon but has significant procedural and clinical consequences. It results in a high rate of ancillary rescue procedures (including surgery) and is associated with a higher risk of arterial thrombosis and complications from wire retrieval attempts. The risk of wire fracture may be avoided with carefully adherence to the IFU.
['Isom|Nicholas|N|0000-0003-3251-2054', 'Masoomi|Reza|R|', 'Thors|Axel|A|', 'Bunte|Matthew|M|0000-0002-8768-1376', 'Prasad|Anand|A|', 'Hance|Kirk|K|', 'Gupta|Kamal|K|0000-0002-2440-9033']
D017073:Atherectomy D002406:Catheterization, Peripheral D016208:Databases, Factual D020878:Device Removal D004868:Equipment Failure D005548:Foreign-Body Migration D019981:Health Care Sector D006801:Humans D058729:Peripheral Arterial Disease D012307:Risk Factors D016896:Treatment Outcome D062666:Vascular Access Devices
peripheral arterial disease complications appropriate use atherosclerosis endovascular intervention