Schisandrin B improves cerebral ischemia and reduces reperfusion injury in rats through TLR4/NF-κB signaling pathway inhibition.
It has been established that poor outcomes in ischemic stroke patients are associated with the post-reperfusion inflammatory response and up-regulation of TLR4. Therefore, suppression of the TLR4 signaling pathway constitutes a potential neuroprotective therapeutic strategy. Schisandrin B, a compound extracted from Schisandra chinensis, has been shown to possess anti-inflammatory and neuroprotective properties. However, the mechanism remains unclear. In the present study, the therapeutic effect of schisandrin B was assessed following cerebral ischemia and reperfusion (I/R) injury in a model of middle cerebral artery occlusion and reperfusion (MCAO/R) in rats. The effects of schisandrin B were investigated with particular emphasis on TLR4 signal transduction and on the inflammatory response. Schisandrin B treatment conferred significant protection against MCAO/R injury, as evidenced by decreases in infarct volume, neurological score, and the number of apoptotic neurons and inflammatory signaling molecules.


ABBREVIATIONS
I/R: schemia/reperfusion; IL: interleukin; MCAO/R: middle cerebral artery occlusion and reperfusion; NF-κB: nuclear; TLR4: Toll-like receptor 4; TNF-α: tumor necrosis factor-α.
['Fan|Xingjuan|X|', 'Elkin|Kenneth|K|', 'Shi|Yunwei|Y|', 'Zhang|Zhihong|Z|', 'Cheng|Yaqin|Y|', 'Gu|Jingxiao|J|', 'Liang|Jiale|J|', 'Wang|Caiping|C|', 'Ji|Xunming|X|']
D000818:Animals D000893:Anti-Inflammatory Agents D002545:Brain Ischemia D034242:Cyclooctanes D017705:Lignans D008297:Male D016328:NF-kappa B D011083:Polycyclic Compounds D017207:Rats, Sprague-Dawley D015427:Reperfusion Injury D015398:Signal Transduction D051197:Toll-Like Receptor 4
Schisandrin B neuroprotection apoptosis inflammation ischemia/reperfusion injury