BiVO4/Fe3O4@polydopamine superparticles for tumor multimodal imaging and synergistic therapy.
BACKGROUND
Despite tremendous progress has been achieved in tumor theranostic over the past decade, accurate identification and complete eradication of tumor cells remain a great challenge owing to the limitation of single imaging modality and therapeutic strategy.


RESULTS
Herein, we successfully design and construct BiVO4/Fe3O4@polydopamine (PDA) superparticles (SPs) for computed tomography (CT)/photoacoustic (PA)/magnetic resonance (MR) multimodal imaging and radiotherapy (RT)/photothermal therapy (PTT) synergistic therapy toward oral epithelial carcinoma. On the one hand, BiVO4 NPs endow BiVO4/Fe3O4@PDA SPs with impressive X-ray absorption capability due to the high X-ray attenuation coefficient of Bi, which is beneficial for their utilization as radiosensitizers for CT imaging and RT. On the other hand, Fe3O4 NPs impart BiVO4/Fe3O4@PDA SPs with the superparamagnetic property as a T2-weighted contrast agent for MR imaging. Importantly, the aggregation of Fe3O4 NPs in SPs and the presence of PDA shell greatly improve the photothermal conversion capability of SPs, making BiVO4/Fe3O4@PDA SPs as an ideal photothermal transducer for PA imaging and PTT. By integrating advantages of various imaging modalities (CT/PA/MR) and therapeutic strategies (RT/PTT), our BiVO4/Fe3O4@PDA SPs exhibit the sensitive multimodal imaging feature and superior synergistic therapeutic efficacy on tumors.


CONCLUSIONS
Since there are many kinds of building blocks with unique properties appropriating for self-assembly, our work may largely enrich the library of nanomateirals for tumor diagnosis and treatment.
['Wang|Ze|Z|', 'Wang|Guan|G|', 'Kang|Tingting|T|', 'Liu|Shuwei|S|', 'Wang|Lu|L|', 'Zou|Haoyang|H|', 'Chong|Yu|Y|', 'Liu|Yi|Y|http://orcid.org/0000-0003-0548-6073']
D000818:Animals D001729:Bismuth D003287:Contrast Media D005290:Ferric Compounds D006801:Humans D007211:Indoles D008279:Magnetic Resonance Imaging D009682:Magnetic Resonance Spectroscopy D064847:Multimodal Imaging D053758:Nanoparticles D010789:Phototherapy D011108:Polymers D014057:Tomography, X-Ray Computed D014638:Vanadates
Superparticles Multimodal imaging BiVO4 nanoparticles Fe3O4 nanoparticles Synergy therapy