Significance of surgical management for cystic prolactinoma.
PURPOSE
It is generally accepted that dopamine agonists (DA) represent the first-line treatment for most patients with prolactinoma, and patients become candidates for surgical intervention when DA is contraindicated. Surgical indication for cystic prolactinoma remains controversial. This study was performed to investigate the significance of surgery for cystic prolactinoma.


METHODS
A total of 28 patients that underwent transsphenoidal resection of prolactinoma between February 2004 and May 2016 were reviewed. Five consecutive patients with cystic prolactinoma were included in this study. Our surgical strategy for cystic prolactinoma was categorized as follows: first, when the purpose of surgical resection was normalization of the prolactin level, aggressive resection was performed; second, when volume reduction was essential to relieve the visual symptoms and headache, internal decompression was performed followed by DA therapy. The clinical outcomes were analyzed accordingly.


RESULTS
All cystic prolactinoma were resected via the transsphenoidal approach without any complications, and all symptoms including visual impairment and hypogonadal activity were finally relieved combined with medication.


CONCLUSIONS
Surgery for cystic prolactinoma could be a better option. Transsphenoidal surgery is relatively safe to remove the cystic prolactinoma, additionally it can normalize the prolactine level and achieve adequate and rapid decompression of optic chiasm. The risk of transsphenoidal surgery is highly dependent on the skill of the surgeon and treatment decision for cystic prolactinoma needs to be individualized for each patient.
['Ogiwara|Toshihiro|T|', 'Horiuchi|Tetsuyoshi|T|', 'Nagm|Alhusain|A|', 'Goto|Tetsuya|T|', 'Hongo|Kazuhiro|K|']
D000328:Adult D018491:Dopamine Agonists D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D010911:Pituitary Neoplasms D015175:Prolactinoma D016896:Treatment Outcome
Prolactinoma Dopamine agonists Treatment Transsphenoidal surgery Cystic adenoma