Amides and Heparin-Like Polymer Co-Functionalized Graphene Oxide Based Core @ Polyethersulfone Based Shell Beads for Bilirubin Adsorption.
Excessive bilirubin in the body of patient with liver dysfunction or metabolic obstruction may cause jaundice with irreversible brain damage, and new type of adsorbent for bilirubin is under frequent investigation. Herein, graphene oxide based core @ polyethersulfone-based shell beads are fabricated by phase inversion method, amides and heparin-like polymer are introduced to functionalize the core-shell beads. The beads are successfully prepared with obvious core-shell structure, adequate thermostability and porous shell. Clotting times and protein adsorption are investigated to inspect the hemocompatibility property of the beads. The adsorption of bilirubin is systematically investigated by evaluating the effects of contacting time, initial concentration and temperature on the adsorption, which exhibits improved bilirubin adsorption amount for the beads with amides contained cores or/and shells. It is worth believing that the amides and heparin-like polymer co-functionalized core-shell beads may be utilized in the field of hemoperfusion for bilirubin adsorption.
['He|Chao|C|', 'Li|Mingyuan|M|', 'Zhang|Jue|J|', 'Yan|Bingqing|B|', 'Zhao|Weifeng|W|', 'Sun|Shudong|S|', 'Zhao|Changsheng|C|0000-0002-4619-3499']
D000327:Adsorption D000577:Amides D001663:Bilirubin D006108:Graphite D006493:Heparin D006801:Humans D007700:Kinetics D011108:Polymers D017550:Spectroscopy, Fourier Transform Infrared D013450:Sulfones D013696:Temperature D013818:Thermogravimetry
graphene oxide polyethersulfone bilirubin core-shell beads