Proliferation and osteo/odontogenic differentiation of stem cells from apical papilla regulated by Zinc fingers and homeoboxes 2: An in vitro study.
In the process of tooth root development, stem cells from the apical papilla (SCAPs) can differentiate into odontoblasts and form root dentin, however, molecules regulating SCAPs differentiation have not been elucidated. Zinc fingers and homeoboxes 2 (ZHX2) is a novel transcriptional inhibitor. It is reported to modulate the development of nerve cells, liver cells, B cells, red blood cells, and so on. However, the role of ZHX2 in tooth root development remains unclear. In this study, we explored the potential role of ZHX2 in the process of SCAPs differentiation. The results showed that overexpression of ZHX2 upregulated the expression of osteo/odontogenic related genes and ALP activity, inhibited the proliferation of SCAPs. Consistently, ZHX2 knockdown reduced SCAPs mineralization and promoted SCAPs proliferation. These results indicated that ZHX2 plays a critical role in the proliferation and osteo/odontogenic differentiation of SCAPs.
['Wan|Fang|F|', 'Gao|Lifen|L|', 'Lu|Yating|Y|', 'Ma|Hongxin|H|', 'Wang|Hongxing|H|', 'Liang|Xiaohong|X|', 'Wang|Yan|Y|', 'Ma|Chunhong|C|']
D000293:Adolescent D049109:Cell Proliferation D002478:Cells, Cultured D005260:Female D018398:Homeodomain Proteins D006801:Humans D008297:Male D009805:Odontogenesis D010006:Osteoblasts D010012:Osteogenesis D010486:Periapical Tissue D013234:Stem Cells D014157:Transcription Factors
Proliferation Osteo/odontogenic differentiation SCAPs ZHX2