MicroRNAs as Biomarkers for Germ Cell Tumors.
Two clusters of microRNAs have been discovered highly expressed by seminoma and nonseminoma germ cell tumors. They are secreted in blood of patients with testicular germ cell tumors and can be extracted from the serum or plasma and quantified by real-time-polymerase chain reaction. Results have confirmed the feasibility of the technique and demonstrated that sensitivity and specificity of those microRNAs in detecting viable germ cell tumors are higher than with current methods. If operation characteristics are confirmed in larger studies, those microRNAs will be valuable to manage equivocal clinical scenarios characterized by high uncertainty and high risk of over-treatment or under-treatment.
['Nappi|Lucia|L|', 'Nichols|Craig|C|']
D014408:Biomarkers, Tumor D006801:Humans D008297:Male D035683:MicroRNAs D009367:Neoplasm Staging D009373:Neoplasms, Germ Cell and Embryonal D012680:Sensitivity and Specificity D013736:Testicular Neoplasms
MicroRNAs Biomarkers Germ cell tumor Management of testis cancer Testicular cancer