A study of IgG antibodies to the ApoB protein in non-ST segment elevation acute coronary syndrome.
OBJECTIVES
It has long been noted that there is an association of antibodies against oxidized low-density lipoprotein (oxLDL) with cardiovascular disease, but the anti-oxLDL antibody has not been confirmed as a biomarker for prediction of acute coronary syndrome (ACS). Apolipoprotein B (ApoB) may carry the epitopes for the immune response to oxLDL. The present work was thus undertaken to detect circulating antibodies to ApoB in non-ST segment elevation ACS (NSTE-ACS).


DESIGN
A total of 130 patients with NSTE-ACS and 201 control subjects were recruited. Six ApoB-derived peptipe antigens (Ag1-Ag6) were used to develop an in-house enzyme-linked immunosorbent assay to examine circulating anti-ApoB IgG levels.


RESULTS
The anti-Ag1 IgG level was significantly higher in the patient group than the control group (P < 0.001) and the non-ST segment elevation myocardial infarction appeared to be the main form of NSTE-ACS contributing to the increased levels of anti-Ag1 IgG (P < 0.001); there was no significant alteration in the levels of IgG to the other 5 antigens in NSTE-ACS.


CONCLUSIONS
Circulating anti-ApoB IgG test may be useful for prediction of NSTE-ACS although further confirmation is needed in large-scale clinical studies.
['Zhang|Xueying|X|', 'Yu|Bo|B|', 'Jin|Yuanzhe|Y|', 'Lei|Mingming|M|', 'Zhang|Xiaohong|X|', 'Duan|Zhiying|Z|', 'Lin|Yingzi|Y|', 'Megson|Ian L|IL|', 'Wei|Jun|J|']
D054058:Acute Coronary Syndrome D000368:Aged D001055:Apolipoproteins B D004562:Electrocardiography D004797:Enzyme-Linked Immunosorbent Assay D005260:Female D006801:Humans D007074:Immunoglobulin G D008077:Lipoproteins, LDL D008297:Male D008875:Middle Aged D009203:Myocardial Infarction D011237:Predictive Value of Tests
antibody ApoB Non-ST segment elevation acute coronary syndrome atherosclerosis