Simultaneous assessment of cognitive and affective functions in multiple system atrophy and cortical cerebellar atrophy in relation to computerized touch-panel screening tests.
Cognitive impairment and affective dysfunction of multiple system atrophy (MSA) and cortical cerebellar atrophy (CCA) have not been simultaneously examined comparing standard test batteries and a sensitive tool to detect subtle cognitive decline in patients. In the present study, we simultaneously examined cognitive and affective ability in MSA with predominant cerebellar ataxia (MSA-C, n=25), MSA with predominant parkinsonism (MSA-P, n=8), and CCA (n=14) patients using computerized touch panel screening tests. Mini-mental state examination (MMSE), Hasegawa dementia scale-revised (HDS-R), frontal assessment battery (FAB), and Montreal cognitive assessment (MoCA) scores were significantly lower in MSA-C patients than in age-and gender-matched normal controls. One MSA-C patient showed a decrease in the regional cerebral blood flow (rCBF) of the frontal lobe. MSA-P patients showed no such cognitive decline. Only FAB and MoCA scores were significantly lower in the CCA patients. MSA and CCA patients also showed a mild to moderate depressive state. Touch-panel screening tests demonstrated a significant decline of beating devils game in all three disease groups including MSA-P patients, and a significant extension of the flipping cards game only in MSA-C patients. The present study demonstrated different cognitive and affective functions among MSA-C, MSA-P, and CCA patients, and a sensitive screening method for cognitive assessment using touch-panel tests.
['Kawahara|Yuko|Y|', 'Ikeda|Yoshio|Y|', 'Deguchi|Kentaro|K|', 'Kurata|Tomoko|T|', 'Hishikawa|Nozomi|N|', 'Sato|Kota|K|', 'Kono|Syoichiro|S|', 'Yunoki|Taijun|T|', 'Omote|Yoshio|Y|', 'Yamashita|Toru|T|', 'Abe|Koji|K|']
D000368:Aged D001284:Atrophy D002525:Cerebellar Cortex D002526:Cerebellar Diseases D003072:Cognition Disorders D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D019964:Mood Disorders D019578:Multiple System Atrophy D009483:Neuropsychological Tests D014584:User-Computer Interface
Multiple system atrophy Cortical cerebellar atrophy Cognitive impairment Touch panel screening test Regional cerebral blood flow Affective disorder