Stopped in its tracks: negative regulation of the dynein motor by the yeast protein She1.
How do cells direct the microtubule motor protein dynein to move cellular components to the right place at the right time? Recent studies in budding yeast shed light on a new mechanism for directing dynein, involving the protein She1. She1 restricts where and when dynein moves the nucleus and mitotic spindle. Experiments with purified proteins show that She1 binds to microtubules and inhibits dynein by stalling the motor on its track. Here I describe what we have learned so far about She1, based on a combination of genetic, cell biology, and biophysical approaches. These findings set the stage for further interrogation of the She1 mechanism, and raise the question of whether similar mechanisms exist in other species.
['Moore|Jeffrey K|JK|']
D002467:Cell Nucleus D003593:Cytoplasm D004398:Dyneins D005656:Fungal Proteins D015966:Gene Expression Regulation, Fungal D016681:Genome, Fungal D008870:Microtubules D018995:Myosin Heavy Chains D024701:Myosin Type V D012441:Saccharomyces cerevisiae D029701:Saccharomyces cerevisiae Proteins D008941:Spindle Apparatus D013997:Time Factors
dynein microtubules motor proteins cell division