POPs' effect on cardiometabolic and inflammatory profile in a sample of women with obesity and hypertension.
Persistent organic pollutants (POPs) are man-made compounds with metabolic disruption impact. We investigated the effect of POP exposure in the cardiometabolic and inflammatory profile in a population of women with obesity and hypertension. In 43 premenopausal women (22 treated vs. 21 nontreated) undergoing bariatric surgery, blood and adipose tissue samples (visceral (vAT) and abdominal subcutaneous (scAT)) were collected. Median concentrations of ∑HCH and ∑POPs in vAT were significantly higher in treated women. VAT ∑HCH and scAT ∑HCH and ∑POPs concentrations were positively correlated with systolic blood pressure in the non-treated group. Our findings suggest that exposure to POPs and its accumulation in vAT and circulating in plasma may be associated to a higher cardiovascular risk in women with obesity and hypertension, with or without antihypertensive treatment.
['Ferro|Ana|A|', 'Teixeira|Diana|D|0000-0002-2162-1450', 'Pestana|Diogo|D|', 'Monteiro|Rosário|R|', 'Santos|Cristina C|CC|0000-0002-7109-1101', 'Domingues|Valentina F|VF|0000-0003-3472-849X', 'Polónia|Jorge|J|', 'Calhau|Conceição|C|']
D000273:Adipose Tissue D000328:Adult D000393:Air Pollutants D004781:Environmental Exposure D005260:Female D006801:Humans D006973:Hypertension D024821:Metabolic Syndrome D008875:Middle Aged D009765:Obesity D009930:Organic Chemicals D018570:Risk Assessment D055815:Young Adult
obesity hypertension persistent organic pollutants Cardiometabolic risk inflammation