Biomechanics of small intestine during distraction enterogenesis with an intraluminal spring.
During recent years, distraction enterogenesis has been extensively studied as a treatment for short bowel syndrome, which is the most common cause of intestinal failure. Although different strategies such as parenteral nutrition and surgical lengthening have been used to manage the difficulties that patients with SBS deal with, these treatments are associated with high complication rates. Distraction enterogenesis uses mechanical force to increase the length and stimulate growth of the small intestine. In this study we combine in vivo experiments with computational modeling to explore the biomechanics of spring dependent distraction enterogenesis. We hypothesize that the self-expanding spring provides mechanical force for elastic tissue lengthening and triggers cellular proliferation. The additional growth of the intestine suggests signaling between mechanical stress and tissue response. We developed a computational modeling platform to test the correlation of applied mechanical force and tissue growth. We further validated our computational models with experimental measurements using spring-mediated distraction enterogenesis in a porcine model. This modeling platform can incorporate patient biometrics to estimate an individual's tissue response to spring mediated distraction enterogenesis.
['Hosseini|Hadi S|HS|', 'Taylor|Jordan S|JS|', 'Wood|Lauren S Y|LSY|', 'Dunn|James C Y|JCY|']
D000818:Animals D001696:Biomechanical Phenomena D049109:Cell Proliferation D004548:Elasticity D007421:Intestine, Small D055595:Mechanical Phenomena D013552:Swine D015626:Tissue Expansion
Biomechanics of small intestine Distraction enterogenesis Short bowel syndrome Computational mechanics of soft tissue Finite element modeling