Spectroscopy analysis of chitosan-glibenclamide hydrogels.
The structure of glibenclamide, 5-chloro-N-(2-{4-[(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)-2-methoxybenzamide, an important antidiabetic drug, has been studied both chitosan using theoretical calculations like Gibbs free energy, electrostatic potential, FTIR and NMR spectroscopy. Fourier transform infrared (FT-IR) spectroscopy reveals information about the molecular interactions of chemical components and is useful to characterization of hydrogel. Nucleophilic and electrophilic regions were calculated using the electrostatic potential.
['Delgadillo-Armendariz|Nancy-Liliana|NL|', 'Rangel-Vázquez|Norma-Aurea|NA|', 'García-Castañón|Alejandra-Ibeth|AI|']
D048271:Chitosan D003432:Cross-Linking Reagents D005905:Glyburide D020100:Hydrogels D007004:Hypoglycemic Agents D009682:Magnetic Resonance Spectroscopy D008958:Models, Molecular D017550:Spectroscopy, Fourier Transform Infrared D055672:Static Electricity D013816:Thermodynamics
Glibenclamide Chitosan FTIR NMR