The effect of acute alcohol intoxication on gut wall integrity in healthy male volunteers; a randomized controlled trial.
The aim of the study is to determine the effect of acute alcohol consumption on enterocytes. Chronic alcohol consumption has been known to induce a decrease in gut wall integrity in actively drinking alcoholics and patients with alcohol-induced liver disease. Data on the extent of the damage induced by acute alcohol consumption in healthy human beings is scarce. Studies show that heavy incidental alcohol consumption is a growing problem in modern society. Data on this matter may provide insights into the consequences of this behavior for healthy individuals. In a randomized clinical trial in crossover design, 15 healthy volunteers consumed water one day and alcohol the other. One blood sample was collected pre-consumption, five every hour post-consumption, and one after 24 h. Intestinal fatty acid binding protein (I-FABP) was used as a marker for enterocyte damage. Liver fatty acid binding protein (L-FABP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT) were used as markers for hepatocyte damage. Lipopolysaccharide binding protein (LBP) and soluble CD14 (sCD14) were used as a measure of translocation. Interleukin-6 (IL-6) was used to assess the acute inflammatory response to endotoxemia. Alcohol consumption caused a significant increase in serum I- and L-FABP levels, compared to water consumption. Levels increased directly post-consumption and decreased to normal levels within 4 h. LBP, sCD14, and IL-6 levels were not significantly higher in the alcohol group. Moderate acute alcohol consumption immediately damages the enterocyte but does not seem to cause endotoxemia.
['de Jong|W J|WJ|', 'Cleveringa|A M|AM|', 'Greijdanus|B|B|', 'Meyer|P|P|', 'Heineman|E|E|', 'Hulscher|J B|JB|']
D000293:Adolescent D000328:Adult D000435:Alcoholic Intoxication D018592:Cross-Over Studies D000431:Ethanol D050556:Fatty Acid-Binding Proteins D041981:Gastrointestinal Tract D064368:Healthy Volunteers D006801:Humans D008297:Male D016037:Single-Blind Method D013997:Time Factors D055815:Young Adult
Alcohol Gut wall integrity Fatty acid binding protein Endotoxemia