Temperament and character profiles associated with depression and treatment response in patients with or without comorbid substance abuse.
There is limited knowledge on the relationship between temperament and character profiles and substance abuse comorbidity in depressed patients. We recruited 127 depressed patients without alcohol use problems (non-AUP) and 89 depressed patients with alcohol use problems (AUP). We assessed all patients using the Temperament and Character Inventory (TCI-R) at baseline and after 6 weeks of treatment. Using univariate general linear models (GLMs), we analyzed differences in TCI-R between AUP and non-AUP. GLMs were also used in analyzing the associations between TCI-R changes and antidepressive treatment responses measured with changes in Montgomery Åsberg Depression Rating Scale score (ΔMADRS). Alcohol use explained independently significant proportions of the variation in Novelty Seeking, Self-Directedness, and Persistence. Reward Dependence score change explained 14.1% of the ΔMADRS in AUP, but was non-significant in non-AUP. Character score changes in Self-Directedness and Self-Transcendence explained together 14.1% of ΔMADRS in non-AUP, whereas they were all non-significant in AUP. AUP compared with non-AUP patients had lower Self-Directedness and Persistence and higher Novelty Seeking scores. Detected changes in Reward Dependence and lower Self-Directedness in AUP patients could be reflective of different biological mechanisms associated with depressive symptomatology in alcohol abuse. Changes in character are associated with acute treatment response in non-AUP.
['Paavonen|Vesa|V|', 'Luoto|Kaisa|K|', 'Koivukangas|Antti|A|', 'Lassila|Antero|A|', 'Leinonen|Esa|E|', 'Kampman|Olli|O|']
D000293:Adolescent D000328:Adult D000928:Antidepressive Agents D002605:Character D003863:Depression D003866:Depressive Disorder D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D010555:Personality Inventory D012307:Risk Factors D019966:Substance-Related Disorders D013694:Temperament D055815:Young Adult
Temperament Character Treatment response Substance abuse Alcohol abuse Major depressive disorder Personality