Positive Association between Basal Total Testosterone Circulating Levels and Tumor Grade Groups at the Time of Diagnosis of Prostate Cancer.
INTRODUCTION
To test the hypothesis that basal total testosterone (TT) levels are associated with International Society of Urologic Pathology (ISUP) tumor grade groups at the time of diagnosis of prostate cancer (PCA).


METHODS
From November 2014 to March 2018, preoperative TT and PSA were measured in 601 consecutive patients who were not under androgen deprivation and undergoing surgery for PCA. Patients were classified into low (ISUP 1; reference group), intermediate (ISUP 2/3), and high (ISUP 4/5) tumor grade groups. The association of TT and other clinical factors with tumor groups was evaluated by multinomial multivariate regression analysis.


RESULTS
218 patients (36.3%) were biopsy low grade (ISUP 1), 297 (49.4%) intermediate grade (ISUP 2/3), and 86 (14.3) high grade (ISUP 4/5). Median basal circulating TT levels progressively increased as tumor grade groups increased. On multivariate models, TT, among other clinical factors, was positively associated with the risk of intermediate (OR 1.001; p = 0.023) and high tumor grades (OR 1.002, p = 0.022) compared to low-grade cancers.


CONCLUSIONS
Increased endogenous circulating basal TT levels were positively associated with ISUP tumor grade groups at the time of diagnosis indicating a close association with tumor biology. Basal TT levels may reflect the heterogeneity of the cancer population.
['Porcaro|Antonio B|AB|', 'Tafuri|Alessandro|A|', 'Sebben|Marco|M|', 'Pirozzi|Marco|M|', 'Processali|Tania|T|', 'Rizzetto|Riccardo|R|', 'Amigoni|Nelia|N|', 'Shakir|Aliasger|A|', 'Tiso|Leone|L|', 'Cerrato|Clara|C|', 'Panunzio|Andrea|A|', 'De Michele|Mario|M|', 'Cerruto|Maria Angela|MA|', 'Brunelli|Matteo|M|', 'Migliorini|Filippo|F|', 'Siracusano|Salvatore|S|', 'Artibani|Walter|W|']
D000368:Aged D006801:Humans D008297:Male D008875:Middle Aged D060787:Neoplasm Grading D011471:Prostatic Neoplasms D012189:Retrospective Studies D013739:Testosterone
Total testosterone Tumor grade Tumor grade group Prostate cancer