Downregulation of miR-377 Promotes Oral Squamous Cell Carcinoma Growth and Migration by Targeting HDAC9.
microRNAs are the post-transcriptional regulators implicated in the initiation and progression of various cancer types, including oral squamous cell carcinoma (OSCC). Here, we investigated the role of miR-377 in OSCC tumorigenesis. miR-377 expression was reduced in OSCC samples and cell line (UPCI-SCC-116), and was associated with patient survival. In vitro restoration of miR-377 repressed cell growth, induced apoptosis, and reduced cell migration. We identified HDAC9 as a target of miR-377 and found miR-377 to regulate HDAC9 and its pro-apoptotic target, NR4A1/Nur77. Our findings show that miR-377 targets HDAC9 pathway in OSCC, suggesting that miR-377-HDAC9 axis may provide a novel therapeutic target for OSCC therapy.
['Rastogi|Bhawna|B|', 'Kumar|Amit|A|', 'Raut|Satish K|SK|', 'Panda|Naresh K|NK|', 'Rattan|Vidya|V|', 'Joshi|Nainesh|N|', 'Khullar|Madhu|M|']
D020413:3' Untranslated Regions D017209:Apoptosis D001483:Base Sequence D001665:Binding Sites D002294:Carcinoma, Squamous Cell D045744:Cell Line, Tumor D002465:Cell Movement D049109:Cell Proliferation D015536:Down-Regulation D004794:Enzyme Repression D015972:Gene Expression Regulation, Neoplastic D006655:Histone Deacetylases D006801:Humans D053208:Kaplan-Meier Estimate D035683:MicroRNAs D009062:Mouth Neoplasms D057105:Nuclear Receptor Subfamily 4, Group A, Member 1 D034622:RNA Interference D012097:Repressor Proteins
Oral squamous cell carcinoma Histone deacetylase 9 microRNA-377