Clinical Characteristics and Therapeutic Outcomes of Metastatic Peritoneal Carcinomatosis in Non-Small-Cell Lung Cancer.
Background
Metastatic peritoneal carcinomatosis (MPC) is not common in patients with non-small cell lung cancer (NSCLC), and the clinical characteristics and treatment outcomes are still unclear.


Patients and Methods
We recruited 46 NSCLC patients with MPC at Keio University and affiliated hospitals (Keio Lung Oncology Group) between January 2011 and December 2017, then retrospectively investigated their clinical characteristics and the impact of treatment interventions on their survival.


Results
The profile of histological subtype was predominantly adenocarcinoma and 15 patients harbored driver oncogenes. Univariate and multivariate analysis demonstrated that performance status and the presence of a driver oncogene were significantly associated with the prolonged overall survival (OS). Regarding treatment, the median OS in the treatment group (9.3 months) was significantly longer than in the best supportive care group (1.3 months) (P < 0.0001).


Conclusion
The prognosis of MPC in NSCLC patients who receive only the best supportive care is poor, but therapeutic intervention may improve prognosis.
['Tani|Tetsuo|T|0000-0001-5719-2697', 'Nakachi|Ichiro|I|0000-0002-3930-9318', 'Ikemura|Shinnosuke|S|', 'Nukaga|Shigenari|S|', 'Ohgino|Keiko|K|', 'Kuroda|Aoi|A|', 'Terai|Hideki|H|', 'Masuzawa|Keita|K|', 'Shinozaki|Taro|T|', 'Ishioka|Kota|K|', 'Funatsu|Yohei|Y|', 'Koh|Hidefumi|H|', 'Fukunaga|Koichi|K|0000-0001-7460-1990', 'Soejima|Kenzo|K|', '|||']
metastatic peritoneal carcinomatosis NSCLC EGFR intraperitoneal dissemination malignant ascites peritoneal nodule