Comparative genome analysis and molecular epidemiology of the reemerging porcine epidemic diarrhea virus strains isolated in Korea.
Porcine epidemic diarrhea virus (PEDV), a member of the Coronaviridae family, is an enveloped, positive-sense, single-stranded RNA virus, which causes severe diarrhea and dehydration in suckling pigs. We detected three PEDV strains from ten small intestine samples from piglets with acute diarrhea and we determined the complete genome sequences of the reemerging Korean PEDV field isolates, except for the noncoding regions from both ends. The complete genome sequences of the strains were identical or almost identical (one synonymous single-nucleotide polymorphism (SNP) in the ORF1a/1b genomic sequence). Interestingly, comparative genome analysis of recent Korean PEDV isolates and other strains revealed that the complete genome sequences of recent Korean strains were almost identical (99.9%) to those of the US PEDV strains isolated in 2013. These results suggest that the three reemerging Korean strains are distinct from previous endemic Korean PEDV strains and has been recently introduced into Korea from oversea with high likelihood.
['Choi|Jong-Chul|JC|', 'Lee|Kun-Kyu|KK|', 'Pi|Jae Ho|JH|', 'Park|Seung-Yong|SY|', 'Song|Chang-Seon|CS|', 'Choi|In-Soo|IS|', 'Lee|Joong-Bok|JB|', 'Lee|Dong-Hun|DH|', 'Lee|Sang-Won|SW|']
D000818:Animals D021821:Communicable Diseases, Emerging D018352:Coronavirus Infections D016679:Genome, Viral D023281:Genomics D010802:Phylogeny D053485:Porcine epidemic diarrhea virus D012367:RNA, Viral D056910:Republic of Korea D017422:Sequence Analysis, DNA D013552:Swine D013553:Swine Diseases
Porcine epidemic diarrhea virus Complete genome Animal virus Coronavirus Phylogenetic analysis