Fatal human eosinophilic meningo-encephalitis caused by CNS co-infection with Halicephalobus gingivalis and West Nile virus.
The saprophytic nematode Halicephalobus is a rare cause of fatal human meningo-encephalitis, and West Nile virus is neurotropic flavivirus implicated in a variety of clinical neurologic syndromes. Here we report a case of rapidly progressive CNS encephalopathy and death. Serologic, immuno-histochemical, histopathologic and nucleic acid studies demonstrate the presence of active Halicephalobus and West Nile virus in the CNS tissue. This is the first reported case of co-infection with these neurotropic pathogens.
['Anwar|M A|MA|', 'Gokozan|H N|HN|', 'Ball|M K|MK|', 'Otero|J|J|', 'McGwire|B S|BS|']
D000818:Animals D020809:Central Nervous System Helminthiasis D060085:Coinfection D017809:Fatal Outcome D005260:Female D006801:Humans D008875:Middle Aged D009348:Nematoda D009349:Nematode Infections D014901:West Nile Fever D014902:West Nile virus
Halicephalobus West Nile virus Eosinophilic encephalitis Granuloma