FS-7 inhibits MGC-803 cells growth in vitro and in vivo via down-regulating glycolysis.
In this study, we investigated the anticancer effects of FS-7, a flavonoid salicylate derivative, in human gastric carcinoma MGC-803 cell line and studied its preliminary anticancer effects. FS-7 displayed greater in vitro cytotoxicity against MGC-803 cell line compared with 5-Fu and had a certain extent of selectivity to cancer cells. The flow cytometry analysis revealed that FS-7 induced apoptosis MGC-803 cells and mainly caused cells arrest in the G2/M phase in a concentration-dependent manner. Additionally, FS-7 inhibited the colony formation and cell migration in a concentration-dependent manner. Notably, FS-7 noticeably down-regulated glycolysis-related protein HIF-1α, HK-II and PFKP expression in a concentration-dependent manner, possibly causing glycolysis inhibition. Importantly, compared with 5-Fu, FS-7 showed better anticancer activity in the MGC-803 xenograft murine tumor models. Collectively, the present study provided a promising anticancer drug candidate for gastric cancer therapy.
['Deng|Xiangping|X|', 'Li|Zhongli|Z|', 'Xiong|Runde|R|', 'Liu|Juan|J|', 'Liu|Renbo|R|', 'Peng|Junmei|J|', 'Chen|Yanming|Y|', 'Lei|Xiaoyong|X|', 'Cao|Xuan|X|', 'Zheng|Xing|X|', 'Xie|Zhizhong|Z|', 'Tang|Guotao|G|']
D000818:Animals D000970:Antineoplastic Agents D045744:Cell Line, Tumor D002470:Cell Survival D004305:Dose-Response Relationship, Drug D015536:Down-Regulation D005419:Flavonoids D006019:Glycolysis D006131:Growth Inhibitors D006801:Humans D051379:Mice D008807:Mice, Inbred BALB C D008819:Mice, Nude D011897:Random Allocation D013274:Stomach Neoplasms D023041:Xenograft Model Antitumor Assays
FS-7 MGC-803 Glycolysis Anticancer HIF-1α