Identification of a novel fusion gene, TRIM52-RACK1, in oral squamous cell carcinoma.
Gene fusion is caused by the linkage of previously separate genes or sequences. Recently, an increasing number of novel fusion genes have been identified and associated with tumor progression, and several of them have been suggested as promising targets for tumor therapy. However, there are hardly any studies reporting the association of fusion genes with the progression of oral squamous cell carcinoma (OSCC). In this study, we identified a total of 11 fused genes in OSCC cells. We further analyzed the structure of one fused gene, TRIM52-RACK1, and detected its function in tumor progression in vitro. We found that TRIM52-RACK1 was caused by a deletion of 181,257,187-181,247,386 at 5q35.3 and it promoted OSCC cell proliferation, migration, and invasion. Therefore, TRIM52-RACK1 can be a promising target for tumor therapy in OSCC.
['Pan|Tao|T|', 'Li|Yong-Guo|YG|', 'Li|Ke-Yi|KY|', 'Chen|Cheng|C|', 'Xu|Kai|K|', 'Yuan|Dao-Ying|DY|', 'Zou|Bo|B|', 'Meng|Zhen|Z|']
D002294:Carcinoma, Squamous Cell D045744:Cell Line, Tumor D002465:Cell Movement D049109:Cell Proliferation D006801:Humans D009062:Mouth Neoplasms D009361:Neoplasm Invasiveness D015514:Oncogene Proteins, Fusion
TRIM52-RACK1 Oral squamous cell carcinoma Fused gene RACK1 TRIM52