Modulation of nesfatin-1-induced cardiovascular effects by the central cholinergic system.
Nesfatin-1, a peptide whose receptor is yet to be identified, has been shown to be involved in the modulation of feeding, stress, and metabolic responses. Recently, increasing evidence has supported a modulatory role of nesfatin-1 in cardiovascular activity. We have previously reported that nesfatin-1 causes an increase in blood pressure in normotensive and hypotensive rats by increasing plasma catecholamine, vasopressin, and renin levels. Recent reports suggest that nesfatin-1 may activate the central cholinergic system. However, there is no evidence showing an interaction between central nesfatin-1 and the cholinergic system. Therefore, this study aimed to determine whether the central cholinergic system may have a functional role in the nesfatin-1-induced cardiovascular effect observed in normotensive rats. Intracerebroventricular injection of nesfatin-1 caused short-term increases in mean arterial pressure and heart rate responses including bradycardic/tachycardic phases in normotensive animals. Central injection of nesfatin-1 increased the acetylcholine and choline levels in the posterior hypothalamus, as shown in microdialysis studies. Central pretreatment with the cholinergic muscarinic receptor antagonist atropine and/or nicotinic receptor antagonist mecamylamine blocked nesfatin-1-induced cardiovascular effects. In conclusion, the results show that centrally administered nesfatin-1 produces a pressor effect on blood pressure and heart rate responses including bradycardic/tachycardic phases in normotensive rats. Moreover, according to our findings, the central cholinergic system can modulate nesfatin-1-evoked cardiovascular activity.
['Aydin|Begum|B|', 'Guvenc|Gokcen|G|', 'Altinbas|Burcin|B|', 'Niaz|Nasir|N|', 'Yalcin|Murat|M|']
D000109:Acetylcholine D000818:Animals D001794:Blood Pressure D001921:Brain D002135:Calcium-Binding Proteins D002395:Catecholamines D018678:Cholinergic Agents D004268:DNA-Binding Proteins D006339:Heart Rate D007022:Hypotension D008297:Male D008464:Mecamylamine D009419:Nerve Tissue Proteins D000080866:Nucleobindins D017207:Rats, Sprague-Dawley D014662:Vasoconstrictor Agents D014667:Vasopressins
Nesfatin-1 Blood pressure Heart rate Cholinergic muscarinic and nicotinic receptors Posterior hypothalamic choline/acetylcholine