UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability.
Persistent virus infections can cause pathogenesis that is debilitating or lethal. During these infections, virus-specific T cells fail to protect due to weakened antiviral activity or failure to persist. These outcomes are governed by histone modifications, although it is unknown which enzymes contribute to T cell loss or impaired function over time. In this study, we show that T cell receptor-stimulated CD8+ T cells increase their expression of UTX (ubiquitously transcribed tetratricopeptide repeat, X chromosome) to enhance gene expression. During chronic lymphocytic choriomeningitis virus (LCMV) infection in mice, UTX binds to enhancers and transcription start sites of effector genes, allowing for improved cytotoxic T lymphocyte (CTL)-mediated protection, independent of its trimethylation of histone 3 lysine 27 (H3K27me3) demethylase activity. UTX also limits the frequency and durability of virus-specific CD8+ T cells, which correspond to increased expression of inhibitory receptors. Thus, UTX guides gene expression patterns in CD8+ T cells, advancing early antiviral defenses while reducing the longevity of CD8+ T cell responses.
['Mitchell|Joseph E|JE|', 'Lund|Makayla M|MM|', 'Starmer|Josh|J|', 'Ge|Kai|K|', 'Magnuson|Terry|T|', 'Shpargel|Karl B|KB|', 'Whitmire|Jason K|JK|']
antiviral defense LCMV CD8(+) T cell function epigenetics histone demethylation persistent infection