Novel codons in rat Pdx-1 complementary DNA.
OBJECTIVES
Pancreatic and duodenal homeobox-1 (Pdx-1) is a homeodomain-containing transcription factor essential for pancreatic development, beta-cell differentiation and the maintenance of mature beta cell function. To transfect the expression vectors of Pdx-1 in the mammalian cells, the complementary DNA (cDNA) of Pdx-1 was conducted.


RESULTS
Novel codons and amino acids sequences were detected in rat Pdx-1 cDNA. Comparing the previous reports regarding rat Pdx-1 cDNA, 3 novel codons (ACA141CCA, AAG720CCG, GTT742GCT) were detected. The amino acids sequences based on the detected cDNA sequences confirmed those, which were already available in public databases. The present study described novel codons in rat Pdx-1 cDNA. The results may be useful for an effective research against pancreatic development, regeneration or carcinogenesis regarding Pdx-1 expressions.
['Kiba|Takayoshi|T|']
D000818:Animals D003062:Codon D018076:DNA, Complementary D005260:Female D018398:Homeodomain Proteins D051381:Rats D017208:Rats, Wistar D015534:Trans-Activators
Rat Pdx-1 cDNA