Membrane potential resonance in non-oscillatory neurons interacts with synaptic connectivity to produce network oscillations.
Several neuron types have been shown to exhibit (subthreshold) membrane potential resonance (MPR), defined as the occurrence of a peak in their voltage amplitude response to oscillatory input currents at a preferred (resonant) frequency. MPR has been investigated both experimentally and theoretically. However, whether MPR is simply an epiphenomenon or it plays a functional role for the generation of neuronal network oscillations and how the latent time scales present in individual, non-oscillatory cells affect the properties of the oscillatory networks in which they are embedded are open questions. We address these issues by investigating a minimal network model consisting of (i) a non-oscillatory linear resonator (band-pass filter) with 2D dynamics, (ii) a passive cell (low-pass filter) with 1D linear dynamics, and (iii) nonlinear graded synaptic connections (excitatory or inhibitory) with instantaneous dynamics. We demonstrate that (i) the network oscillations crucially depend on the presence of MPR in the resonator, (ii) they are amplified by the network connectivity, (iii) they develop relaxation oscillations for high enough levels of mutual inhibition/excitation, and (iv) the network frequency monotonically depends on the resonators resonant frequency. We explain these phenomena using a reduced adapted version of the classical phase-plane analysis that helps uncovering the type of effective network nonlinearities that contribute to the generation of network oscillations. We extend our results to networks having cells with 2D dynamics. Our results have direct implications for network models of firing rate type and other biological oscillatory networks (e.g, biochemical, genetic).
['Bel|Andrea|A|', 'Rotstein|Horacio G|HG|0000-0002-4387-5160']
D000465:Algorithms D001683:Biological Clocks D006801:Humans D016014:Linear Models D008564:Membrane Potentials D008959:Models, Neurological D016571:Neural Networks, Computer D009434:Neural Pathways D009474:Neurons D017711:Nonlinear Dynamics D013569:Synapses
Latent time scales Inhibitory networks Neuronal filters Preferred frequency response