Factors Associated with Increased Alpha-Tocopherol Content in Milk in Response to Maternal Supplementation with 800 IU of Vitamin E.
BACKGROUND
Vitamin E supplementation might represent an efficient strategy to increase the vitamin E content in milk. The present study aimed to evaluate the impact of supplementation with 800 IU RRR-alpha-tocopherol on the alpha-tocopherol content of milk and the factors associated with the increase in vitamin E.


METHODS
Randomized clinical trial with 79 lactating women from Brazil, who were assigned to the control group, or to the supplemented group (800 IU of RRR-alpha-tocopherol). Milk and serum were collected between 30 and 90 days after delivery (collection 1), and on the next day (collection 2). Alpha-tocopherol was analyzed using high-performance liquid chromatography.


RESULTS
In the supplemented group, the alpha-tocopherol content in serum and milk increased after supplementation (p < 0.001). In the multivariate analysis, only alpha-tocopherol in milk (collection 1) was associated with the level of this vitamin in milk after supplementation (β = 0.927, p < 0.001), and binary logistic regression showed that the dietary intake was the only determinant for the greater effect of supplementation in milk.


CONCLUSION
The pre-existing vitamin level in milk and diet are determinants for the efficacy of supplementation in milk, suggesting that in populations with vitamin E deficiency, high-dose supplementation can be used to restore its level in milk.
['de Sousa Rebouças|Amanda|A|0000-0002-4222-4761', 'Costa Lemos da Silva|Ana Gabriella|AG|0000-0001-7761-2708', 'Freitas de Oliveira|Amanda|A|', 'Thalia Pereira da Silva|Lorena|L|0000-0001-6730-5536', 'de Freitas Felgueiras|Vanessa|V|0000-0003-0983-0011', 'Cruz|Marina Sampaio|MS|', 'Silbiger|Vivian Nogueira|VN|0000-0002-9252-0278', 'da Silva Ribeiro|Karla Danielly|KD|0000-0002-2251-5967', 'Dimenstein|Roberto|R|']
D000328:Adult D001942:Breast Feeding D019587:Dietary Supplements D005260:Female D006801:Humans D016015:Logistic Models D039382:Maternal Nutritional Physiological Phenomena D008895:Milk, Human D014810:Vitamin E D055815:Young Adult D024502:alpha-Tocopherol
clinical trial lactating women lactation breastfeeding infants