Increased Levels of Serum Protein Complexes Are Associated with Type 2 Diabetes.
Objective: To screen novel biomarkers in the levels of protein complexes for type 2 diabetes mellitus (T2DM). Methods: Serum immunoinflammation-related protein complexes (IIRPCs) and diabetes-related protein complexes (DRPCs) in 1537 serum samples including 504 healthy controls, 320 patients with prediabetes, and 713 patients with T2DM were analyzed using an optimized native polyacrylamide gel electrophoresis (native-PAGE). Results: Seven patterns of serum IIRPCs and four patterns of serum DRPCs were observed in the study population, respectively. Significant increase in the levels of serum IIRPCs in T2DM was detected relative to healthy controls. Change trends of serum DRPCs are as below: patients with T2DM>patients with prediabetes> healthy controls. Conclusion: Our findings suggest that increased levels of serum IIRPCs and DRPCs were associated with T2DM.
['Liu|Yujie|Y|', 'Wu|Yunpeng|Y|', 'Wang|Yanmin|Y|', 'Zhang|Mo|M|', 'Li|Zhili|Z|']
D000328:Adult D015415:Biomarkers D001798:Blood Proteins D003924:Diabetes Mellitus, Type 2 D005260:Female D006801:Humans D007249:Inflammation D008297:Male D008875:Middle Aged D046912:Multiprotein Complexes D011236:Prediabetic State
protein complex type 2 diabetes diabetes-related protein complex