Biconcave Carbon Nanodisks for Enhanced Drug Accumulation and Chemo-Photothermal Tumor Therapy.
It is considered a significant challenge to construct nanocarriers that have high drug loading capacity and can overcome physiological barriers to deliver efficacious amounts of drugs to solid tumors. Here, the development of a safe, biconcave carbon nanodisk to address this challenge for treating breast cancer is reported. The nanodisk demonstrates fluorescent imaging capability, an exceedingly high loading capacity (947.8 mg g-1 , 94.78 wt%) for doxorubicin (DOX), and pH-responsive drug release. It exhibits a higher uptake rate by tumor cells and greater accumulation in tumors in a mouse model than its carbon nanosphere counterpart. In addition, the nanodisk absorbs and transforms near-infrared (NIR) light to heat, which enables simultaneous NIR-responsive drug release for chemotherapy and generation of thermal energy for tumor cell destruction. Notably, this NIR-activated dual therapy demonstrates a near complete suppression of tumor growth in a mouse model of triple-negative breast cancer when DOX-loaded nanodisks are administered systemically.
['Mu|Qingxin|Q|', 'Wang|Hui|H|', 'Gu|Xinyu|X|', 'Stephen|Zachary R|ZR|', 'Yen|Charles|C|', 'Chang|Fei-Chien|FC|', 'Dayringer|Christopher J|CJ|', 'Zhang|Miqin|M|0000-0001-8974-1494']
D000818:Animals D000903:Antibiotics, Antineoplastic D002244:Carbon D045744:Cell Line, Tumor D002470:Cell Survival D003131:Combined Modality Therapy D004317:Doxorubicin D016503:Drug Delivery Systems D005260:Female D006979:Hyperthermia, Induced D007259:Infrared Rays D051379:Mice D008807:Mice, Inbred BALB C D049329:Nanostructures D010778:Photochemotherapy D014018:Tissue Distribution
carbon nanodisks combination therapy drug carriers enhanced tumor accumulation photothermal conversion