Health-Related Quality of Life in Adult Patients with Common Variable Immunodeficiency Disorders and Impact of Treatment.
PURPOSE
Common variable immunodeficiency disorder (CVID) is a primary immunodeficiency disease (PIDD) often associated with severe and chronic infections. Patients commonly receive immunoglobulin (Ig) treatment to reduce the cycle of recurrent infection and improve physical functioning. However, how Ig treatment in CVID affects quality of life (QOL) has not been thoroughly evaluated. The purpose of a recent Immune Deficiency Foundation (IDF) mail survey was to assess the factors that are associated with QOL in patients with CVID receiving Ig treatment.


METHODS
A 75-question survey developed by the IDF and a 12-item Short Form Health Survey (SF-12) to assess QOL were mailed to adults with CVID. Mean SF-12 scores were compared between patients with CVID and the general US adult population normative sample.


RESULTS
Overall, 945 patients with CVID completed the surveys. More than half of the patients (54.9%) received intravenous Ig and 44.9% received subcutaneous Ig treatment. Patients with CVID had significantly lower SF-12 scores compared with the general US population regardless of sex or age (p < 0.05). Route of IgG replacement did not dramatically improve QOL. SF-12 scores were highest in patients with CVID who have well-controlled PIDD, lacked physical impairments, were not bothered by treatment, and received Ig infusions at home.


CONCLUSION
These data provide insight into what factors are most associated with physical and mental health, which can serve to improve QOL in patients in this population. Improvements in QOL can result from early detection of disease, limiting digestive system disease, attention to fatigue, and implementation of an individual treatment plan for the patient.
['Rider|Nicholas L|NL|http://orcid.org/0000-0003-2549-0678', 'Kutac|Carleigh|C|', 'Hajjar|Joud|J|', 'Scalchunes|Chris|C|', 'Seeborg|Filiz O|FO|', 'Boyle|Marcia|M|', 'Orange|Jordan S|JS|']
D000293:Adolescent D000328:Adult D000367:Age Factors D017668:Age of Onset D000368:Aged D002648:Child D002675:Child, Preschool D000066491:Clinical Decision-Making D017074:Common Variable Immunodeficiency D016208:Databases, Factual D019468:Disease Management D005260:Female D006306:Health Surveys D006801:Humans D016756:Immunoglobulins, Intravenous D007223:Infant D007231:Infant, Newborn D008297:Male D008875:Middle Aged D000071066:Patient Reported Outcome Measures D011788:Quality of Life D012720:Severity of Illness Index D018434:Sickness Impact Profile D014481:United States D055815:Young Adult
quality of life common variable immunodeficiency Primary immunodeficiency diseases mental health physical health reported health