Burn-associated bloodstream infections in pediatric burn patients: Time distribution of etiologic agents.
BACKGROUND
Infections are the leading cause of morbidity and mortality in patients with burns in burn units. Bloodstream infections (BSIs) in patients with burns may result from burn wound infection, use of invasive devices such as central venous catheters, and translocation of the gastrointestinal flora.


OBJECTIVE
In this study, we investigated the distribution and antimicrobial drug resistance of causative pathogens in children with burns and the durational changes of microorganisms in the distribution of BSIs in children.


METHODS
This study was conducted at the Pediatric Burn Unit (PBU) of Dr. Behçet Uz Children Research and Training Hospital during the period of November 2008-April 2015. The study subjects were all the patients admitted to the PBU, in whom microorganisms were isolated at least from one of the cultures, including blood and catheter cultures.


RESULTS
Gram-positive bacteria were the most common causative agents of BSI in patients with burns (66.4%), followed by gram-negative bacteria (22.1%) and fungi (11.5%). The median duration of development of BSIs caused by gram-positive bacteria from the time of burn was 5 days (ranging from 2 to 54 days of burn), which was significantly shorter than that of BSIs caused by gram-negative bacteria (12 days) and fungal pathogens (13 days).


CONCLUSION
The etiologic agents of BSIs in children may differ from those in adults. Gram-negative drug-resistant bacteria such as multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii were important agents of BSI in patients with burns, especially in the long term; however, gram-positive bacteria should also be considered while deciding the antimicrobial therapy, especially in the early periods of burn.
['Devrim|İlker|İ|', 'Kara|Ahu|A|', 'Düzgöl|Mine|M|', 'Karkıner|Aytaç|A|', 'Bayram|Nuri|N|', 'Temir|Günyüz|G|', 'Şencan|Arzu|A|', 'Sorguç|Yelda|Y|', 'Gülfidan|Gamze|G|', 'Hoşgör|Münevver|M|']
D000151:Acinetobacter Infections D000293:Adolescent D000890:Anti-Infective Agents D016470:Bacteremia D002056:Burns D002177:Candidiasis D055499:Catheter-Related Infections D002405:Catheterization, Central Venous D062905:Central Venous Catheters D002648:Child D002675:Child, Preschool D004352:Drug Resistance, Microbial D004927:Escherichia coli Infections D005260:Female D016469:Fungemia D016905:Gram-Negative Bacterial Infections D016908:Gram-Positive Bacterial Infections D006801:Humans D007223:Infant D007710:Klebsiella Infections D008297:Male D008826:Microbial Sensitivity Tests D011552:Pseudomonas Infections D012307:Risk Factors D013203:Staphylococcal Infections D013997:Time Factors D014421:Turkey
Burn-associated bloodstream infections Pediatric burn patients Burn Children