Prevalence and severity of depression and anxiety in patients with systemic lupus erythematosus: An epidemiologic study in Iranian patients.
OBJECTIVES
We aimed to evaluate the prevalence of depression and anxiety in patients with systemic lupus erythematosus (SLE) and explore their association with demographic and clinical features.


METHODS
In this cross-sectional study, 166 SLE patients in rheumatology center of Shariati hospital, Tehran University of Medical Sciences were enrolled. SLE disease activity index (SLEDAI) and Beck and Cattell inventories for evaluation of depression and anxiety were completed for each patient.


RESULTS
The mean age of patients was 33.1 ± 11.1 years and 92.2% of them were female. Two patients (1.2%) had only depression (without anxiety), while 36 patients (21.6%) had only anxiety (without depression). Meanwhile, 105 patients (63.3%) had mixed depression-anxiety and 23 patients (13.8%) did not have either depression or anxiety. Mean daily dose of prednisolone and number of administered drugs did not show significant difference between different subgroups of patients. In assessment of clinical and therapeutic items, no significant correlation between severity of depression (P = 0.65) and anxiety (P = 0.36) with daily dose of prednisolone in SLE patients was observed. There was no significant association between SLEDAI and severity of depression or anxiety. Occupational status had significant correlation with severity of depression and anxiety (P = 0.005).On the contrary, no significant correlation between number of administered drugs and severity of depression and anxiety was present.


CONCLUSION
This study indicated the high prevalence of depression and anxiety among SLE patients and reinforced the need of a comprehensive psychiatric work-up in SLE.
['Kheirandish|Masoumeh|M|', 'Faezi|Seyedeh Tahereh|ST|', 'Paragomi|Pedram|P|', 'Akhlaghi|Maassoumeh|M|', 'Gharibdoost|Farhad|F|', 'Shahali|Ashraf|A|', 'Fini|Mahboubeh Ebrahimpour|ME|', 'Akbarian|Mahmood|M|']
D000328:Adult D001007:Anxiety D003430:Cross-Sectional Studies D003863:Depression D005260:Female D006801:Humans D007492:Iran D008180:Lupus Erythematosus, Systemic D008297:Male D008875:Middle Aged D015995:Prevalence D011788:Quality of Life D012720:Severity of Illness Index D055815:Young Adult
Depression Anxiety Systemic lupus erythematosus