Pleiotropic Role of Notch Signaling in Human Skin Diseases.
Notch signaling orchestrates the regulation of cell proliferation, differentiation, migration and apoptosis of epidermal cells by strictly interacting with other cellular pathways. Any disruption of Notch signaling, either due to direct mutations or to an aberrant regulation of genes involved in the signaling route, might lead to both hyper- or hypo-activation of Notch signaling molecules and of target genes, ultimately inducing the onset of skin diseases. The mechanisms through which Notch contributes to the pathogenesis of skin diseases are multiple and still not fully understood. So far, Notch signaling alterations have been reported for five human skin diseases, suggesting the involvement of Notch in their pathogenesis: Hidradenitis Suppurativa, Dowling Degos Disease, Adams-Oliver Syndrome, Psoriasis and Atopic Dermatitis. In this review, we aim at describing the role of Notch signaling in the skin, particularly focusing on the principal consequences associated with its alterations in these five human skin diseases, in order to reorganize the current knowledge and to identify potential cellular mechanisms in common between these pathologies.
['Gratton|Rossella|R|', 'Tricarico|Paola Maura|PM|0000-0002-1954-4126', 'Moltrasio|Chiara|C|', 'Lima Estevão de Oliveira|Ana Sofia|AS|0000-0001-9540-6756', 'Brandão|Lucas|L|', 'Marzano|Angelo Valerio|AV|0000-0002-8160-4169', 'Zupin|Luisa|L|0000-0001-5886-9129', 'Crovella|Sergio|S|0000-0001-8493-1168']
D005786:Gene Expression Regulation D006801:Humans D009154:Mutation D051880:Receptors, Notch D015398:Signal Transduction D012871:Skin Diseases
proliferation differentiation Notch pathway skin disorder