Effect of intracameral carbachol in phacoemulsification surgery on macular morphology and retinal vessel caliber.
OBJECTIVE
To investigate the effects of intracameral carbachol in phacoemulsification surgery on central macular thickness (CMT), total macular volume (TMV) and retinal vessel caliber (RVC).


MATERIALS AND METHODS
In this prospective consecutive case series, 82 patients underwent uneventful phacoemulsification and in-the-bag intraocular lens implantation. Unlike patients in the control group (43 eyes), patients in the study group (42 eyes) were injected with intracameral 0.01% carbachol during surgery. Spectral-domain optical coherence tomography (OCT) was used to analyze the parameters of CMT, TMV and RVC.


RESULTS
On the first postoperative day, mean CMT and TMV decreased markedly in the carbachol group, though these values did not change significantly in the control group. During follow-up visits, no statistically significant differences between the groups occurred regarding changes in mean CMT (p = 0.25, first day; p = 0.80, first week; p = 0.95, first month). However, change in mean TMV between groups on the first postoperative day was statistically significant (p = 0.01, first day; p = 0.96, first week; p = 0.68, first month). RVC values were similar on the preoperative and postoperative first days in both groups (p > 0.05).


DISCUSSION
Results suggest that the effect of intracameral carbachol on macular OCT is related to pharmacological effects, as well as optic events (e.g. miosis).


CONCLUSION
Intracameral carbachol given during cataract surgery decreases macular thickness and volume in the early postoperative period but does not exert any gross effect on RVC.
['Pekel|Gökhan|G|', 'Yagci|Ramazan|R|', 'Acer|Semra|S|', 'Cetin|Ebru Nevin|EN|', 'Cevik|Ali|A|', 'Kasikci|Alper|A|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D002217:Carbachol D005260:Female D006801:Humans D019654:Lens Implantation, Intraocular D008266:Macula Lutea D008297:Male D008875:Middle Aged D008916:Miotics D018918:Phacoemulsification D012161:Retinal Artery D012169:Retinal Vein D041623:Tomography, Optical Coherence
Carbachol phacoemulsification intracameral injection macula