A case presentation of a fatal dengue myocarditis showing evidence for dengue virus-induced lesion.
Dengue is a prevalent arthropod-borne viral disease in tropical and subtropical areas of the globe. Dengue clinical manifestations include asymptomatic infections; undifferentiated fever; dengue fever, which is characterized by fever, headache, retroorbital pain, myalgia, and arthralgia; and a severe form of the disease denominated dengue haemorrhagic fever/dengue shock syndrome, characterized by haemoconcentration, thrombocytopenia, and bleeding tendency. However, atypical manifestations, such as liver, central nervous system, and cardiac involvement, have been increasingly reported. We report an atypical and rare presentation of dengue disease marked by a dramatic and fatal cardiogenic shock due to acute myocarditis. Histopathological analysis of heart tissue showed several multifocal areas of muscle necrosis and intense interstitial oedema associated with clusters of virus particles inside the cardiomyocytes and in the interstitial space, providing evidence of a possible direct action of dengue virus on myocardium.
['Miranda|Carlos Henrique|CH|', 'Borges|Marcos de Carvalho|Mde C|', 'Schmidt|André|A|', 'Pazin-Filho|Antônio|A|', 'Rossi|Marcos Antônio|MA|', 'Ramos|Simone Gusmão|SG|', 'Lopes da Fonseca|Benedito Antônio|BA|']
D000328:Adult D017809:Fatal Outcome D005260:Female D006801:Humans D009205:Myocarditis D019595:Severe Dengue D012770:Shock, Cardiogenic
dengue fever cardiogenic shock acute myocarditis Acute heart failure