Endoscopic treatment of symptomatic VUR disease after the renal transplantation: analysis of 49 cases.
BACKGROUND
To evaluate the outcome of endoscopic treatment for symptomatic vesicoureteral reflux (VUR) disease in renal transplantation patients and to determine the factors that were associated with the success rate of the treatment.


METHODS
A total of 121 symptomatic VUR diseases diagnosed between 2014 and 2018 in 3560 renal transplant patients. The results of 49 VUR cases that presented with febrile urinary tract infection (UTI) and were hospitalized for antibiotic treatment were included in the study. Reflux was detected by voiding cystourethrogram and treatment was performed by endoscopic Deflux® injection. The result of endoscopic treatment was evaluated clinically by 3 months periods.


RESULTS
The mean time between transplantation and endoscopic treatment was 59.6 (5-132) months, and the mean follow-up period after the endoscopic treatment was 14 (6-48) months, respectively. The success rate after the first injection was 59.1% (n = 29) and 67.3% (n = 33) after the second injection. One patient developed anuria, one patient febrile UTI and four patients developed minimal macroscopic hematuria after the procedure.


CONCLUSIONS
Endoscopic treatment of symptomatic VUR in transplanted kidney is a safe and feasible procedure. The amount of bulking agent or duration between the transplantation and diagnosis of VUR does not have any impact on the success of the treatment. However, the younger age of the patients and the female gender seem to have a positive effect on the outcome of the procedure.
['Balaban|Muhsin|M|', 'Ozkaptan|Orkunt|O|', 'Cubuk|Alkan|A|http://orcid.org/0000-0001-9322-9717', 'Sahan|Ahmet|A|', 'Duzenli|Mustafa|M|', 'Tuncer|Murat|M|']
D000328:Adult D000367:Age Factors D000368:Aged D001002:Anuria D003558:Cystoscopy D003911:Dextrans D005260:Female D006417:Hematuria D006801:Humans D006820:Hyaluronic Acid D016030:Kidney Transplantation D008297:Male D008875:Middle Aged D019233:Retreatment D012737:Sex Factors D016896:Treatment Outcome D014552:Urinary Tract Infections D064804:Urological Agents D014718:Vesico-Ureteral Reflux
Endoscopic treatment Renal transplantation Vesicoureteral reflux