Preparation, Characterization, and Properties of Inclusion Complexes of Balofloxacin with Cyclodextrins.
The study mainly aimed to improve the aqueous solubility of Balofloxacin (BLFX) by preparing the inclusion complexes (ICs) of BLFX with cyclodextrins (CDs). In this study, ICs in solid state were obtained by using beta-CD (β-CD), 2-hydroxypropyl-β-CD (HP-β-CD), 2, 6-dimethyl-β-CD (DM-β-CD) through a freeze-drying technique. The formation of ICs was confirmed through Fourier-transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffraction, nuclear magnetic resonance, and scanning electron microscopy. Results demonstrated that the water solubility and dissolution rates of three ICs were distinctly improved than that of parent BLFX. Bacteriostatic experiment manifested that the antibacterial effect of BLFX was not inhibited after encapsulation in CDs. The damage of BLFX to kidney and liver cells was reduced. Consequently, successful preparation of the ICs of BLFX with CDs provided possibility for devising new dosage form of BLFX, which held great promise for further applications in clinical fields.
['Ren|Xiuyun|X|', 'Qian|Hongyun|H|', 'Tang|Peixiao|P|', 'Tang|Yuling|Y|', 'Liu|Yuanyuan|Y|', 'Pu|Hongyu|H|', 'Zhang|Man|M|', 'Zhao|Ludan|L|', 'Li|Hui|H|']
D002152:Calorimetry, Differential Scanning D004339:Drug Compounding D024841:Fluoroquinolones D005612:Freeze Drying D009682:Magnetic Resonance Spectroscopy D008855:Microscopy, Electron, Scanning D011208:Powders D017550:Spectroscopy, Fourier Transform Infrared D014961:X-Ray Diffraction D047392:beta-Cyclodextrins
inclusion complex balofloxacin cyclodextrin solubility cytotoxicity