Maternal virus infections in pregnancy and type 1 diabetes in their offspring: Systematic review and meta-analysis of observational studies.
Virus infections are implicated in the development of type 1 diabetes based on epidemiological, clinical, in vitro cell-based and molecular studies, and animal models. We reviewed the association between virus infections in pregnant women and development of islet autoimmunity or type 1 diabetes in their offspring. We performed a systematic review and meta-analysis, analysed using random effects models, of human studies from Medline and EMBASE without language restriction. Inclusion criteria were as follows: cohort and case-control studies measuring viral nucleic acid in blood, stool, urine, or tissue, or serological tests for viruses, in pregnant women whose offspring developed islet autoimmunity and/or type 1 diabetes. All studies required sufficient data to calculate odds ratios and 95% confidence intervals. The 10 studies (4 case control, 6 nested-case control) that met the eligibility criteria included 2992 participants (953 offspring, 2039 mothers), with varying study design. The 2 outcomes examined were islet autoimmunity (n = 466) and type 1 diabetes (n = 2526). Meta-analysis showed a significant association between virus infection during pregnancy and clinical type 1 diabetes during childhood (odds ratio 2·16, 95% CI 1·22-3·80; P = 0·008; heterogeneity X2  = 1·65, I2  = 40%), but no association with islet autoimmunity (1·45, 0·63-3·31; P = 0·38; X2  = 1·34, I2  = 25%). The increased risk of type 1 diabetes following maternal virus infection is consistent with viraemia involving the fetus during pregnancy and suggests a potential causative link between antenatal infection and type 1 diabetes. Larger prospective birth studies with more frequent sampling, and pathogenesis studies, are required to more clearly establish an aetiological link.
['Allen|Digby W|DW|0000-0003-0243-4948', 'Kim|Ki Wook|KW|0000-0001-9579-6408', 'Rawlinson|William D|WD|0000-0003-0988-7827', 'Craig|Maria E|ME|0000-0001-6004-576X']
D000328:Adult D015551:Autoimmunity D003922:Diabetes Mellitus, Type 1 D005260:Female D006801:Humans D016017:Odds Ratio D011247:Pregnancy D011251:Pregnancy Complications, Infectious D011254:Pregnancy in Diabetics D011297:Prenatal Exposure Delayed Effects D014777:Virus Diseases
type 1 diabetes islet autoimmunity congenital rubella coxsackievirus cytomegalovirus enterovirus