Rnf43.
RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation. Loss of function of RNF43 results in decrease/lack of degradation of Frizzled with enhancement of Wnt/β-catenin signaling pathway. Mutations of RNF43 have been reported in different cancers. We describe the structure of RNF43, its function and most frequent mutations in different cancers.
['Serra|Stefano|S|', 'Chetty|Runjan|R|']
D000818:Animals D004268:DNA-Binding Proteins D051157:Frizzled Receptors D006801:Humans D008247:Lysosomes D008954:Models, Biological D009154:Mutation D009369:Neoplasms D015513:Oncogene Proteins D009928:Organ Specificity D025521:Tumor Suppressor Proteins D044767:Ubiquitin-Protein Ligases D054875:Ubiquitination D060449:Wnt Signaling Pathway
cancer colorectal cancer gi neoplasms pancreatic