SMARCB1 (INI-1)-Deficient Adenocarcinoma of the Sinonasal Tract: A Potentially Under-Recognized form of Sinonasal Adenocarcinoma with Occasional Yolk Sac Tumor-Like Features.
The classification of sinonasal adenocarcinoma (SNAC) is complex. The high-grade, non-intestinal SNAC group is particularly heterogeneous, with tumors showing widely variable morphology. SMARCB1 (INI-1)-deficient sinonasal carcinoma is a newly described, aggressive tumor that usually resembles sinonasal undifferentiated carcinoma (SNUC) or non-keratinizing squamous cell carcinoma; however, glandular differentiation has been rarely reported and this feature may be under-recognized. We present a dedicated series of 12 SMARCB1-deficient SNACs. All tumors had an oncocytoid/plasmacytoid cytomorphology with variable degrees of glandular differentiation consisting of tubules and cribriform structures with foci of intracellular or intraluminal mucin. Three of 12 tumors exhibited foci of yolk sac tumor-like histologic features. The tumors were uniformly high-grade, with nuclear pleomorphism, elevated mitotic rates and frequent necrosis. By immunohistochemistry, all tumors were entirely SMARCB1-deficient, and 10 of 12 were CK7-positive. Occasional expression of CDX2 (4 of 12), CK20 (3 of 12), and p40 (3 of 10) was seen. Expression of yolk sac markers was variably present in tumors that harbored yolk sac-like areas but also tumors that did not: glypican-3 (10 of 11), SALL4 (6 of 11), HepPar-1 (4 of 11), PLAP (1 of 10), and AFP (1 of 11). SMARCB1-deficient sinonasal carcinoma, particularly the oncocytoid/plasmacytoid form, can demonstrate variable degrees of glandular differentiation. This unexpected morphology combined with variable immunohistochemical results may lead to misdiagnoses of high-grade intestinal or non-intestinal SNAC, myoepithelial carcinoma, or even yolk sac tumor or metastatic hepatocellular carcinoma.
['Shah|Akeesha A|AA|', 'Jain|Deepali|D|', 'Ababneh|Emad|E|', 'Agaimy|Abbas|A|', 'Hoschar|Aaron P|AP|', 'Griffith|Christopher C|CC|', 'Magliocca|Kelly R|KR|', 'Wenig|Bruce M|BM|', 'Rooper|Lisa M|LM|', 'Bishop|Justin A|JA|http://orcid.org/0000-0002-9743-4360']
D000230:Adenocarcinoma D000328:Adult D000368:Aged D000369:Aged, 80 and over D014408:Biomarkers, Tumor D018240:Endodermal Sinus Tumor D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D010255:Paranasal Sinus Neoplasms D010256:Paranasal Sinuses D000071796:SMARCB1 Protein D055815:Young Adult
SMARCB1 Adenocarcinoma Sinonasal SMARCB1-deficient sinonasal carcinoma Yolk sac tumor INI-1