Prognostic Factors on the Positivity for Metastases of the Axillary Lymph Nodes from Primary Breast Cancer.
AIM
The aim of the study was to identify the impact of T stage, the presence of estrogen, progesterone, HER2neu receptors and the values of the Ki67 on the positivity for metastases of the axillary lymph nodes, from primary breast cancer.


MATERIAL AND METHODS
290 surgically treated patients for breast cancer were included in the study. All cases have been analyzed by standard histological analysis including microscopic analysis on standard H&E staining. For determining the molecular receptors - HER2neu, ER, PR, p53 and Ki67, immunostaining by PT LINK immunoperoxidase has been done.


RESULTS
Patients age was ranged between 18-90 years, average of 57.6+11.9. The mean size of the primary tumor in the surgically treated patient was 30.27 + 18.3 mm. On dissection from the axillary pits 8 to 39 lymph nodes were taken out, an average of 13.81+5.56. Metastases have been found in 1 to 23 lymph nodes, an average 3.14+4.71. In 59% of the patients there have been found metastases in the axillary lymph nodes. The univariate regression analysis showed that the location, size of tumor, differentiation of the tumor, stage, the value of the Ki67 and presence of lymphovascular invasion influence on the positivity of the axillary lymph nodes. The presence of the estrogen receptors, progesterone receptors and HER2neu receptors showed that they do not have influence on the positivity for metastatic deposits in axillary lymph nodes. The multivariate model and the logistic regression analysis as independent significant factors or predictors of positivity of the axillary lymph nodes are influenced by the tumor size and the positive lymphovascular invasion.


CONCLUSION
Our study showed that the involving of the axillary lymph nodes is mainly influenced by the size of the tumor and the presence of lymphovascular invasion in the tumor. Ki67 determined proliferative index in the univariate analysis points the important influence of positivity in the axillary lymph nodes, but not in the multivariate regressive analysis.
['Kondov|Borislav|B|', 'Kondov|Goran|G|', 'Spirovski|Zoran|Z|', 'Milenkovikj|Zvonko|Z|', 'Colanceski|Risto|R|', 'Petrusevska|Gordana|G|', 'Pesevska|Meri|M|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D014408:Biomarkers, Tumor D001943:Breast Neoplasms D049109:Cell Proliferation D005260:Female D006801:Humans D007150:Immunohistochemistry D019394:Ki-67 Antigen D008197:Lymph Node Excision D008198:Lymph Nodes D008207:Lymphatic Metastasis D008875:Middle Aged D009361:Neoplasm Invasiveness D009367:Neoplasm Staging D011237:Predictive Value of Tests D018719:Receptor, ErbB-2 D011960:Receptors, Estrogen D011980:Receptors, Progesterone D047368:Tumor Burden D016159:Tumor Suppressor Protein p53 D055815:Young Adult
breast cancer T stage HER2neu receptors Ki67 lymphovascular invasion estrogen receptors progesterone receptors tumor size axillar status