Acute responses of cytokines and adipokines to aerobic exercise in relapsing vs. remitting women with multiple sclerosis.
OBJECTIVE
To examine the acute effect of exercise on cytokines and adipokines during relapse and the remitting phase of multiple sclerosis (MS).


METHODS
Thirty women with MS in the relapsing or remitting phase were matched with fifteen healthy controls. Participants performed a single-bout of aerobic exercise at 60-70% maximal heart rate. Furthermore, five women in the relapsing phase were enrolled (control relapse) and did not receive any intervention. Blood samples were taken before, immediately after, 1-h and 6-h after the exercise.


RESULTS
Levels of IL-10 and TNF-α in response to exercise were similar in healthy and MS remitting subjects. Compared to baseline, TNF-α levels in relapsing subjects were significantly decreased immediately after exercise. Immediately following exercise, leptin levels significantly decreased in relapsing subjects. Adiponectin and IL-6 showed no significant difference between groups.


CONCLUSION
After relapse, exercise does not induce inflammatory cytokine response and temporarily improves both cytokine and adipokine balance.
['Majdinasab|Nastaran|N|', 'Motl|Robert W|RW|', 'Mokhtarzade|Motahare|M|', 'Zimmer|Philipp|P|', 'Ranjbar|Rouholah|R|', 'Keytsman|Charly|C|', 'Cullen|Tom|T|', 'Negaresh|Raoof|R|', 'Baker|Julien S|JS|']
D054392:Adipokines D000328:Adult D016022:Case-Control Studies D016207:Cytokines D015444:Exercise D005260:Female D006801:Humans D016753:Interleukin-10 D020529:Multiple Sclerosis, Relapsing-Remitting D014409:Tumor Necrosis Factor-alpha D055815:Young Adult
Cytokines Adipokines Multiple sclerosis Aerobic interval exercise Inflammation