Salvia plebeia suppresses atopic dermatitis-like skin lesions.
Salvia plebeia R. Br. (Lamiaceae) has been used for folk medicines in Asian countries, including Korea and China, to treat skin inflammatory diseases and asthma. In this study, we investigated the effects of S. plebeia extract (SPE) on atopic dermatitis (AD)-like skin lesions and defined underlying mechanisms of action. We established an AD model in BALB/c mice by repeated local exposure of house dust mite extract (Dermatophagoides farinae extract, DFE) and 2,4-dinitrochlorobenzene (DNCB) to the ears. Repeated alternative treatment of DFE/DNCB caused AD-like skin lesions. The oral administration of SPE decreased AD symptoms based on ear thickness and histopathological analysis, in addition to serum IgE and IgG2a levels. SPE suppressed mast cell infiltration into the ear and serum histamine level. SPE inhibited Th1/Th2/Th17 phenotype CD4(+) T lymphocytes expansion in the lymph node and the expression of Th1/Th2/Th17 cytokines in the ear tissue. To define the underlying mechanisms of action, the tumor necrosis factor (TNF)-α and interferon (IFN)-γ activated human keratinocytes (HaCaT) model was used. SPE significantly suppressed the expression of cytokines and chemokines through the down-regulation of mitogen-activated protein kinases, nuclear factor-κB, and STAT1 in HaCaT cells. Taken together, our results suggest that SPE might be a candidate for the treatment of AD.
['Choi|Jin Kyeong|JK|', 'Oh|Hyun-Mee|HM|', 'Lee|Soyoung|S|', 'Kwon|Taeg Kyu|TK|', 'Shin|Tae-Yong|TY|', 'Rho|Mun-Chual|MC|', 'Kim|Sang-Hyun|SH|']
D000284:Administration, Oral D000818:Animals D001892:Camphanes D002478:Cells, Cultured D016207:Cytokines D003876:Dermatitis, Atopic D004195:Disease Models, Animal D004365:Drugs, Chinese Herbal D004431:Ear, External D005260:Female D006632:Histamine D006801:Humans D007073:Immunoglobulin E D007074:Immunoglobulin G D018836:Inflammation Mediators D015603:Keratinocytes D008198:Lymph Nodes D008407:Mast Cells D008807:Mice, Inbred BALB C D020928:Mitogen-Activated Protein Kinases D016328:NF-kappa B D053723:Panax notoginseng D008517:Phytotherapy D027544:Salvia D027561:Salvia miltiorrhiza D012867:Skin D013601:T-Lymphocytes
Salvia plebeia Atopic Dermatitis Keratinocytes