Cross-Protective IgG and IgA Antibodies against Oncogenic and Non-Oncogenic HPV Genotypes.
OBJECTIVE
The aim of the study was to describe the course of IgG/IgA immune response in women immunized with bivalent vaccine and in women non-vaccinated with HPV infection, as well as evaluating the cross-protection against non-vaccine HPV types.


METHODS
Serum and cervical mucus samples were collected from infected and vaccinated women for HPV detection/genotyping and for detection of IgG/IgA anti-HPV/VLP (Virus-like Particles) by ELISA.


RESULTS
The median absorbance detected in serum samples for anti-HPV-IgG antibodies was higher in vaccinated women when compared to HPV infected women (p <0.01), however, the median absorbance in cervical mucus samples for anti-HPV-IgA was higher in infected women when compared to vaccinated women (p <0.01). Additionally, our analyses also provided additional evidence for cross-protective efficacy of the HPV-16/18 vaccine against HPV-82, -6, -11, -13, -61, -72 and -74.


CONCLUSION
The IgG antibodies were significantly more detected in the serum of vaccinated women, while the IgA was found in greater quantities in cervical samples from those infected by the virus. In addition, there is evidence that the bivalent vaccine provides cross-protection against other non-oncogenic viral subtypes.<br />.
['Costa|Ana Paula|AP|', 'Giraldo|Paulo César|PC|', 'Cobucci|Ricardo Ney|RN|', 'Consolaro|Márcia Lopes|ML|', 'Souza|Raquel Pantarotto|RP|', 'Canário|Luanda Barbara|LB|', 'Machado|Paula Renata|PR|', 'Randall Martins|Rand|R|', 'Vieira Baptista|Pedro|P|', 'Jr|José Eleutério|JE|', 'Gonçalves|Ana Katherine|AK|0000-0002-8351-5119']
D000914:Antibodies, Viral D016022:Case-Control Studies D018290:Cervical Intraepithelial Neoplasia D002584:Cervix Uteri D005260:Female D005500:Follow-Up Studies D005838:Genotype D006801:Humans D007070:Immunoglobulin A D007074:Immunoglobulin G D027383:Papillomaviridae D030361:Papillomavirus Infections D011379:Prognosis D011446:Prospective Studies D002583:Uterine Cervical Neoplasms D014611:Vaccination
HPV Vaccine Cross Protection Immunoglobulin G immunoglobulin A