A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models.
Aim
In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against Cryptococcus spp. and Candida albicans.


Methods
The ability of CHT to act in biofilm and also to interfere with C. albicans adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models.


Results & conclusion
In the present work we verified that CHT is found to inhibit Cryptococcus and C. albicans affecting biofilm in both and inhibited adhesion of Candida to human buccal cells. When we evaluated in vivo, CHT prolonged survival of Galleria mellonella after infections with Cryptococcusgattii, Cryptococcusneoformans or C. albicans and promoted a reduction in the fungal burden to the organs in the murine models. These results demonstrate CHT therapeutic potential.
['Sá|Nívea P|NP|', 'Lima|Caroline M|CM|', 'A Dos Santos|Julliana R|JR|', 'Costa|Marliete C|MC|', 'de Barros|Patrícia P|PP|', 'Junqueira|Juliana C|JC|', 'Vaz|Jéssica A|JA|', 'Oliveira|Renata B|RB|', 'Fuchs|Beth B|BB|', 'Mylonakis|Eleftherios|E|', 'Rosa|Carlos A|CA|', 'Santos|Daniel A|DA|', 'Johann|Susana|S|']
Cryptococcus spp. Candida albicans Galleria mellonella antifungal mice thiazole virulence