4-Hydroxy-pyran-2-one and 3-hydroxy-N-methyl-2-oxindole derivatives of Salinispora arenicola from Brazilian marine sediments.
Three new 3-hydroxy-N-methyl-2-oxindole (1 and 2) and 4-hydroxy-pyran-2-one (3) derivatives, along with the known 3-hydroxy-N-methyl-2-oxindole (4) and 6-methoxy-N-methylisatin (5) were isolated from a marine Salinispora arenicola strain from sediments of the St. Peter and St. Paul Archipelago, Brazil. The structures of the new compounds were elucidated by a combination of spectroscopic (1D and 2D NMR and HR-ESIMS) data, including single-crystal X-ray diffraction analysis for 2 and 3. Compounds 1 to 5 were assayed for their antimicrobial properties, but only 4 and 5 were active against Enterococcus faecalis with MIC value of 15.6 μg/mL.
['da Silva|Alison B|AB|', 'Pinto|Francisco C L|FCL|', 'Silveira|Edilberto R|ER|', 'Costa-Lotufo|Leticia V|LV|', 'Costa|Wendell S|WS|', 'Ayala|Alejandro Pedro|AP|', 'Canuto|Kirley M|KM|', 'Barros|Ayslan B|AB|', 'Araújo|Ana Jérsia|AJ|', 'Marinho Filho|José Delano B|JDB|', 'Pessoa|Otilia Deusdenia L|ODL|']
D000900:Anti-Bacterial Agents D001938:Brazil D013293:Enterococcus faecalis D019015:Geologic Sediments D008826:Microbial Sensitivity Tests D008848:Micromonosporaceae D015394:Molecular Structure D000078183:Oxindoles D012623:Seawater
4-Hydroxy-pyran-2-one 3-Hydroxy-N-methyl-2-oxindole Salinispora arenicola Antimicrobial activity Marine actinomycete X-ray structure analysis