The impact of ABO blood group on COVID-19 infection risk and mortality: A systematic review and meta-analysis.
The 2019 coronavirus disease (COVID-19) has become a global pandemic. Several studies report that ABO blood group polymorphism may be related to COVID-19 susceptibility and clinical outcomes; however, the results are controversial. We conducted a systematic review and meta-analysis to investigate whether ABO blood groups are associated with increased COVID-19 morbidity and mortality. A total of 715 articles were retrieved from seven databases. Ten articles were selected for meta-analysis after removal of duplicates and two levels of screenings. Overall, individuals with blood group A [odds ratio (OR) = 1.33, 95% confidence interval (CI) 1.14 to 1.56] and B (OR = 1.06, 95% CI 1.00 to 1.13) had a substantially higher risk of COVID-19, whereas this was not the case for blood group AB (OR = 1.07, 95% CI 0.88 to 1.30). Individuals with blood group O was not prone to develop the disease (OR = 0.71, 95% CI 0.60 to 0.84). Moreover, the risk of COVID-19 was significantly associated with the Rh-positive blood group (OR = 1.22, 95% CI 0.99 to 1.50). A meta-analysis of 5 studies suggested that blood group A was associated with a significantly increased risk of COVID-19 mortality (OR = 1.25, 95% CI 1.02 to 1.52). Mild publication bias was found in the included studies. This systematic review and meta-analysis indicated that blood groups A and B may be risk factors for COVID-19, whereas the blood group O appears to be protective. Blood group A may be related to unfavourable outcomes. Further rigorous and high-quality research evidence is needed to confirm this association.
['Liu|Nanyang|N|', 'Zhang|Tingting|T|', 'Ma|Lina|L|', 'Zhang|Huiqing|H|', 'Wang|Huichan|H|', 'Wei|Wei|W|', 'Pei|Hui|H|', 'Li|Hao|H|']
D000017:ABO Blood-Group System D000086382:COVID-19 D016022:Case-Control Studies D020022:Genetic Predisposition to Disease D006801:Humans D016017:Odds Ratio D058873:Pandemics D012189:Retrospective Studies D012204:Rh-Hr Blood-Group System D012306:Risk D000086402:SARS-CoV-2 D016019:Survival Analysis
ABO blood group 2019 coronavirus disease Anti-A antibody Virus