Serum and urinary levels of brain-derived neurotrophic factor (BDNF) in enuresis.
OBJECTIVES
Enuresis is one of the most frequently seen psycho-social problems in childhood, which causes anxiety and stress in the child, thus affecting his/her self-respect and quality of life. The aim of the study was to determine the role of bladder function or psychologic factors or both as factors causing enuresis.


METHODS
This study on pediatric patients with primary enuresis included 30 patients with monosymptomatic nocturnal enuresis (MonoNE), 30 patients with polysymptomatic nocturnal enuresis (PolyNE), and 30 healthy controls, making a total of 90 subjects with an age range of 8-18. In all subjects, the levels of serum and urinary Brain-Derived Neurotrophic Factor (BDNF) were measured, in addition to urinary creatinine levels and calculated as BDNF/Cr ng/mg creatinine (BDNF/ Cr).


RESULTS
The serum BDNF results of the PolyNE group (0.949±0.587) were significantly lower than those of the control group (1.158±0.587) (p=0.014). The urinary BDNF results of the PolyNE group (1.107±0.360) were significantly higher than those of both the MonoNE (0.657±0.272) and the control (0.670±0.271) groups (p<0.0001). The BDNF/Cr results of the PolyNE group (1.472±0.714) were significantly higher than those of the MonoNE group (0.956±1.017) and the control group (0.931±0.618) (p=0.044 and p=0.032, respectively).


CONCLUSIONS
In addition to bladder-specific problems, it is possible for anxiety and psychological stress-induced problems to occur in PolyNE. Therefore, in addition to the increasing number of studies on the bladder in enuresis, further studies on the neurogenic and psychogenic aspects of enuresis should be carried out.
['Kurku|Hüseyin|H|', 'Soran|Mustafa|M|', 'Yar|Ahmet|A|', 'Akdam|Neriman|N|', 'Arslan|Şükrü|Ş|', 'Gönen|Murat|M|']
D001007:Anxiety D019208:Brain-Derived Neurotrophic Factor D002648:Child D005260:Female D006801:Humans D008297:Male D053206:Nocturnal Enuresis D011788:Quality of Life D013315:Stress, Psychological D001743:Urinary Bladder D014549:Urinary Incontinence
BDNF Bladder Enuresis monosintomática Enuresis polisintomática FNDC Monosymptomatic
enuresis Neurotrophins Neurotropinas Polysymptomatic enuresis Vejiga