Formation and functions of the corneocyte lipid envelope (CLE).
Corneocytes in mammalian stratum corneum are surrounded by a monolayer of covalently bound ω-OH-ceramides that form the corneocyte (-bound) lipid envelope (CLE). We review here the structure, composition, and possible functions of this structure, with insights provided by inherited and acquired disorders of lipid metabolism. This article is part of a Special Issue entitled The Important Role of Lipids in the Epidermis and their Role in the Formation and Maintenance of the Cutaneous Barrier. Guest Editors: Kenneth R. Feingold and Peter Elias.
['Elias|Peter M|PM|', 'Gruber|Robert|R|', 'Crumrine|Debra|D|', 'Menon|Gopinathan|G|', 'Williams|Mary L|ML|', 'Wakefield|Joan S|JS|', 'Holleran|Walter M|WM|', 'Uchida|Yoshikazu|Y|']
D000818:Animals D000078404:Epidermal Cells D004817:Epidermis D006801:Humans D050356:Lipid Metabolism D008055:Lipids
Corneocyte lipid envelope Acylceramide Essential fatty acid deficiency Gaucher's disease Neutral lipid storage disease Refsum disease