Increased Expression of Oct4, Nanog and CD24 Predicts Poor Response to Chemo-Radiotherapy and Unfavourable Prognosis in Locally Advanced Oral Squamous Cell Carcinoma.
BACKGROUND
Current study investigates the role of Oct4, Nanog and CD24 in locally-advanced oral squamous cell carcinoma (OSCC), to evaluate whether the expression of these markers can predict efficacy of neoadjuvant-chemo-radiotherapy and survival of patients.


METHODS
Biomarker expression was evaluated in 50 homogenously treated patients of locally-advanced OSCC.


RESULTS
Clinical response was complete in 30% (n=15), partial response in 46% (n=23), no response in 24% (n=12). Pathologically, 74% patents (n=37) were responders and 26% were non-responders (n=13). Biomarker-overexpression was seen in 46% cases for Oct4, 54% cases for Nanog and 58% cases for CD24. Oct4, Nanog and CD24 expression showed significant correlation with clinical and pathological response (p <0.05). Three year recurrence-free survival was 71%, overall survival was 66%. Post-treatment advanced pathological N (ypN), post treatment advanced pathological TNM (ypTNM) stage, clinical non-response, pathologic non-response, positive/high expression of all three biomarkers had a significant negative impact on recurrence-free and overall survival.


CONCLUSIONS
Expressions of Oct4, Nanog and CD24 have significant association with treatment response and survival in patients with locally advanced OSCC treated with neoadjuvant chemo-radiation. Survival of these patients is significantly affected by ypN stage, ypTNM stage, expression of all three biomarkers, clinical and pathological response to neoadjuvant therapy.<br />.
['Mishra|Sridhar|S|', 'Tiwari|Vandna|V|', 'Arora|Aditi|A|', 'Gupta|Seema|S|', 'Anand|Nidhi|N|', 'Husain|Nuzhat|N|0000-0003-1831-9063']
D000328:Adult D000368:Aged D014408:Biomarkers, Tumor D051927:CD24 Antigen D002294:Carcinoma, Squamous Cell D059248:Chemoradiotherapy D005260:Female D005500:Follow-Up Studies D006801:Humans D008297:Male D008875:Middle Aged D009062:Mouth Neoplasms D000071317:Nanog Homeobox Protein D050814:Octamer Transcription Factor-3 D011379:Prognosis D012189:Retrospective Studies D015996:Survival Rate
Oct4 Nanog CD24 oral squamous cell carcinoma Cancer stem cells