Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease.
Atherosclerosis, cancer, and various chronic fibrotic conditions are characterized by an increase in the migratory behavior of resident cells and the enhanced invasion of assorted exogenous cells across a stiffened extracellular matrix (ECM). This stiffened scaffold aberrantly engages cellular mechanosignaling networks in cells, which promotes the assembly of invadosomes and lamellae for cell invasion and migration. Accordingly, deciphering the conserved molecular mechanisms whereby matrix stiffness fosters invadosome and lamella formation could identify therapeutic targets to treat fibrotic conditions, and reducing ECM stiffness could ameliorate disease progression.
['Kai|FuiBoon|F|', 'Laklai|Hanane|H|', 'Weaver|Valerie M|VM|']
D000818:Animals D001696:Biomechanical Phenomena D002465:Cell Movement D004194:Disease D005109:Extracellular Matrix D006801:Humans D009361:Neoplasm Invasiveness D000069261:Podosomes
invasion migration cancer cardiovascular disease extracellular matrix stiffness fibrosis