Low eicosapentaenoic acid and gamma-linolenic acid levels in breast adipose tissue are associated with inflammatory breast cancer.
OBJECTIVE
Since it is thought that breast adipose tissue could influence breast cancer clinical presentation, we wanted to characterize specifically the relationship between breast adipose tissue fatty acid profile and Inflammatory Breast cancer (IBC).


METHODS
Two hundred thirty-four women presenting with breast cancer were managed in our centre between January 2009 and December 2011. Breast adipose tissue specimens were collected during breast surgery. We established the biochemical profile of adipose tissue fatty acids (FA) by gas chromatography and assessed whether there were differences in function of the presence of breast inflammation or not.


RESULTS
We found that IBC was associated with decreased levels in breast adipose tissue of eicosapentaenoic acid (EPA), one of the two main polyunsaturated n-3 fatty acids (n-3 PUFA) of marine origin, but also with decreased levels of Gamma Linolenic acid (GLA). Inversely, an increase in palmitic acid levels was associated with IBC.


CONCLUSION
These differences in lipid content may contribute to the occurrence of breast cancer inflammation.
['Chas|Marie|M|', 'Goupille|Caroline|C|', 'Arbion|Flavie|F|', 'Bougnoux|Philippe|P|', 'Pinault|Michelle|M|', 'Jourdan|Marie Lise|ML|', 'Chevalier|Stephan|S|', 'Ouldamer|Lobna|L|']
D000273:Adipose Tissue D000328:Adult D000368:Aged D000369:Aged, 80 and over D001940:Breast D001943:Breast Neoplasms D002849:Chromatography, Gas D015118:Eicosapentaenoic Acid D005260:Female D006801:Humans D058922:Inflammatory Breast Neoplasms D008875:Middle Aged D012189:Retrospective Studies D017965:gamma-Linolenic Acid
Eicosapentaenoic acid Breast cancer Inflammation Adipose samples