Relating Phage Genomes to Helicobacter pylori Population Structure: General Steps Using Whole-Genome Sequencing Data.
The review uses the Helicobacter pylori, the gastric bacterium that colonizes the human stomach, to address how to obtain information from bacterial genomes about prophage biology. In a time of continuous growing number of genomes available, this review provides tools to explore genomes for prophage presence, or other mobile genetic elements and virulence factors. The review starts by covering the genetic diversity of H. pylori and then moves to the biologic basis and the bioinformatics approaches used for studding the H. pylori phage biology from their genomes and how this is related with the bacterial population structure. Aspects concerning H. pylori prophage biology, evolution and phylogeography are discussed.
['Vale|Filipa F|FF|', 'Lehours|Philippe|P|0000-0001-6704-8699']
D000349:Africa D001208:Asia D001499:Bayes Theorem D000073930:Biological Coevolution D005060:Europe D020043:Genes, Essential D016680:Genome, Bacterial D016679:Genome, Viral D016481:Helicobacter Infections D016480:Helicobacter pylori D049690:History, Ancient D063426:Human Migration D006801:Humans D020071:Interspersed Repetitive Sequences D010802:Phylogeny D058974:Phylogeography D039002:Prophages D037521:Virulence Factors D000073336:Whole Genome Sequencing
phage genome Helicobacter pylori evolution phylogeography