Clinical features of patients with nodal marginal zone lymphoma compared to follicular lymphoma: similar presentation, but differences in prognostic factors and rate of transformation.
Nodal marginal zone lymphoma (NMZL) is a rare type of B-cell non-Hodgkin lymphoma. This study assessed the clinical features of 56 patients with NMZL in comparison to 46 patients with follicular lymphoma (FL). Patients with NMZL and FL had a largely similar clinical presentation, but patients with FL had a higher disease stage at presentation, more frequent abdominal lymphadenopathy and bone marrow involvement, and showed more common transformation into diffuse large B-cell lymphoma (DLBCL) during the course of disease. Overall survival and event-free survival were similar for patients with NMZL and FL, but factors associated with worse prognosis differed between the two groups. Transformation into DLBCL was associated with a significantly poorer outcome in both groups, but the phenotypes were different: DLBCL arising in FL was mainly of germinal center B-cell phenotype, whereas DLBCL arising in NMZL was mainly of non-germinal center B-cell phenotype.
['van den Brand|Michiel|M|', 'van der Velden|Walter J F M|WJ|', 'Diets|Illja J|IJ|', 'Ector|Geneviève I C G|GI|', 'de Haan|Anton F J|AF|', 'Stevens|Wendy B C|WB|', 'Hebeda|Konnie M|KM|', 'Groenen|Patricia J T A|PJ|', 'van Krieken|Han J M|HJ|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D002471:Cell Transformation, Neoplastic D005260:Female D006801:Humans D018442:Lymphoma, B-Cell, Marginal Zone D008224:Lymphoma, Follicular D008297:Male D008875:Middle Aged D060787:Neoplasm Grading D009362:Neoplasm Metastasis D009367:Neoplasm Staging D010641:Phenotype D011379:Prognosis D016019:Survival Analysis D063189:Symptom Assessment D055815:Young Adult
nodal marginal zone lymphoma follicular lymphoma transformation clinical presentation prognosis