The Importance of Cellular Senescence in Frailty and Cardiovascular Diseases.
Frailty is a complex clinical syndrome, progressively described in the last thirty years, resulting from multiple impairments across many organs and systems and characterized by a reduction in physiological reserves and increased vulnerability to stressors, as well. Cardiovascular diseases (CVDs) are a common health problem in very old populations. Age-related changes occur throughout the body and in all organs, including the cardiovascular system. Cellular senescence links age-related CVDs and frailty by many mechanisms of particular interest in the aging biology and geriatric syndromes. Cellular senescence may represent the pivotal factor with its senescence-associated secretory phenotype (SASP) leading to systemic inflammation. In this context, SASP may represent the key element in the association between aging, frailty and the development of age-related CVDs.
['Boccardi|Virginia|V|', 'Mecocci|Patrizia|P|']
D000368:Aged D000375:Aging D002318:Cardiovascular Diseases D016922:Cellular Senescence D016330:Frail Elderly D000073496:Frailty D006801:Humans D007249:Inflammation
Senescence Frailty Cardiovascular Aging Inflammation Comorbidities