Protective effect of naringenin against gentamicin-induced nephrotoxicity in rats.
The protective effect of naringenin, a flavonoid compound isolated from citrus fruits, was investigated against nephrotoxicity induced by gentamicin (80mgkg(-1)/day, i.p., for eight days) in rats. Naringenin treatment (50mgkg(-1)/day, p.o.) was administered for eight days, starting on the same day of gentamicin administration. Gentamicin caused significant elevations of serum creatinine, and kidney tissue levels of malondialdehyde, nitric oxide, and interleukin-8, and a significant decrease in renal glutathione peroxidase activity. Naringenin treatment significantly ameliorated the changes in the measured biochemical parameters resulted from gentamicin administration. Also, naringenin markedly attenuated the histopathological renal tissue injury observed with gentamicin. Immunohistochemical examinations showed that naringenin significantly reduced the gentamicin-induced expression of kidney injury molecule-1, vascular endothelial growth factor, inducible nitric oxide synthase, and caspase-9, and increased survivin expression in the kidney tissue. It was concluded that naringenin, through its antioxidant and anti-inflammatory effects, may represent a therapeutic option to protect against gentamicin nephrotoxicity.
['Fouad|Amr A|AA|', 'Albuali|Waleed H|WH|', 'Zahran|Ahmed|A|', 'Gomaa|Wafaey|W|']
D000818:Animals D000900:Anti-Bacterial Agents D004336:Drug Antagonism D044950:Flavanones D005786:Gene Expression Regulation D005839:Gentamicins D007668:Kidney D007677:Kidney Function Tests D008297:Male D018384:Oxidative Stress D020011:Protective Agents D051381:Rats D017207:Rats, Sprague-Dawley D051437:Renal Insufficiency
Naringenin Rats Gentamicin Acute kidney injury