Expanding the chemotherapeutic potential of an established nucleoside analog with selective targeting of telomerase.
The identification of telomerase-mediated telomeric misincorporation of 5-fluoro-2'-deoxyuridine (5-FdU) uncovered a unique approach to telomeric-based therapeutics. Additionally, identification of such a mechanism supports the utility of telomere maintenance mechanisms in guiding therapeutic decisions. Presented here is a unique perspective of 5-FdU and its clinical implications as a telomeric-based therapeutic.
['Whited|Tawna L|TL|0000-0002-6553-5052', 'Taylor|Derek J|DJ|0000-0001-9932-1856']
nucleoside analog telomerase telomere 5-fluoro-2ʹ-deoxyuridine alternative lengthening of telomeres floxuridine