Protective Effect of Sciadopitysin against Isoproternol-Induced Myocardial Infarction in Rats.
The current study enumerates the beneficial role of sciadopitysin (SDN) against isoproternol (ISO)-induced myocardial infarction (MI) in rats. The MI was experimentally induced via subcutaneous injection of ISO in experimental rats. SDN showed to prevent myocardial necrosis via reducing the levels of creatine kinase-MB and lactate dehydrogenase activities. It also showed to improve myocardial ability and decrease infarct volume. The level of cardiac-specific troponin-T (Tn-T), tumor necrosis factor-α and interleukin-6 were showed to be declined in SDN-treated group as determined by ELISA analysis. At the tested dose, SDN causes reduction in oxidative stress via enhancing the levels of glutathione peroxidase and superoxide dismutase, while reducing the level of myeloperoxidase and malondialdehyde. Cardiac histological changes were observed via hematoxylin and eosin staining along with cardiac function after pre- and post administration of SDN. In western blot analysis, SDN showed significant downregulation of cleaved caspase-3 and Bax, whereas Bcl-2 expression was found to be significantly elevated in dose-dependent manner.
['Cai|Yuhua|Y|', 'Li|Yunpeng|Y|']
D000818:Animals D044946:Biflavonoids D002316:Cardiotonic Agents D006321:Heart D007545:Isoproterenol D008297:Male D009203:Myocardial Infarction D009206:Myocardium D009336:Necrosis D018384:Oxidative Stress D019253:Proto-Oncogene Proteins c-bcl-2 D051381:Rats D017207:Rats, Sprague-Dawley
Myocardial infarction Necrosis Oxidative stress Bcl-2 Inflammation