Large pore mesoporous silica induced weight loss in obese mice.
BACKGROUND
There is a need for medical treatments to curb the rising rate of obesity. Weight reduction is correlated with a decrease in associated risk factors and cholesterol levels in humans. Amorphous silica particles have been found to exert a hypocholesterolemic effect in humans, making them popular dietary additives.


AIM
To investigate the effect of mesoporous silica, which possess sharp pore size distributions, on: weight loss, cholesterol, triglycerides and glucose blood levels in obese mice.


MATERIALS & METHODS
Mesoporous silicas with differing pore size were mixed in the high-fat diet of obese mice.


RESULTS
Animals receiving large pore mesoporous silica with a high-fat diet show a significant reduction in body weight and fat composition, with no observable negative effects.


CONCLUSION
Pore size is an important parameter for reduction of body weight and body fat composition by mesoporous silica, demonstrating promising signs for the treatment of obesity.
['Kupferschmidt|Natalia|N|', 'Csikasz|Robert I|RI|', 'Ballell|Lluís|L|', 'Bengtsson|Tore|T|', 'Garcia-Bennett|Alfonso E|AE|']
D000273:Adipose Tissue D000818:Animals D000924:Anticholesteremic Agents D001786:Blood Glucose D002784:Cholesterol D059305:Diet, High-Fat D004195:Disease Models, Animal D005260:Female D005503:Food Additives D006801:Humans D051379:Mice D008810:Mice, Inbred C57BL D050997:Nanomedicine D053758:Nanoparticles D009765:Obesity D016062:Porosity D012822:Silicon Dioxide D014280:Triglycerides D015431:Weight Loss
mesoporous silica obesity cholesterol high-fat diet body weight body fat