Continental Origin for Q Haplogroup Patrilineages in Argentina and Paraguay.
Haplogroup Q originated in Eurasia around 30,000 years ago. It is present in Y-chromosomes from Asia and Europe at rather low frequencies. Since America is undoubtedly one of the continents where this haplogroup is highly represented, it has been defined as one of the founding haplogroups. Its M3 clade has been early described as the most frequent, with pan-American representation. However, it was also possible to find several other haplogroup Q clades at low frequencies. Numerous mutations have been described for haplogroup Q, allowing analysis of its variability and assignment of its geographic origin. We have analyzed 442 samples of unrelated men from Argentina and Paraguay belonging to haplogroup Q; here we report specifically on 27 Q (xM3) lineages. We tested 3 single-nucleotide polymorphisms (SNPs) by amplified product-length polymorphism (APLP) analysis, 3 SNPs for restriction fragment length polymorphism (RFLP) analysis, 15 SNPs by Sanger sequencing, and 17 short tandem repeats (STRs). Our approach allowed us to identify five subhaplogroups. Q-M3 and Q-CTS2730/Z780 are undoubtedly autochthonous lineages and represent the most frequent subhaplogroups, with significant representation in self-defined aboriginal populations, and their autochthonous status has been previously described. The aim of present work was to identify the continental origin of the remaining Q lineages. Thus, we analyzed the STR haplotypes for the samples and compared them with haplotypes described by other authors for the rest of the world. Even when haplogroup Q lineages have been extensively studied in America, some of them could have their origin in post-Columbian human migration from Europe and Middle East.
['Jurado Medina|Laura S|LS|', 'Paz Sepúlveda|Paula B|PB|', 'Ramallo|Virginia|V|', 'Sala|Camila|C|', 'Beltramo|Julieta|J|', 'Schwab|Marisol|M|', 'Motti|Josefina M B|JMB|', 'Santos|María Rita|MR|', 'Cuello|Mariela V|MV|', 'Salceda|Susana|S|', 'Dipierri|José E|JE|', 'Alfaro Gómez|Emma L|EL|', 'Muzzio|Marina|M|', 'Bravi|Claudio M|CM|', 'Bailliet|Graciela|G|']
D000569:Americas D001118:Argentina D001208:Asia D041322:Chromosomes, Human, Y D005060:Europe D005828:Genetics, Population D006239:Haplotypes D006801:Humans D008297:Male D018895:Microsatellite Repeats D008877:Middle East D010239:Paraguay D010802:Phylogeny D020641:Polymorphism, Single Nucleotide
HAPLOGROUPS SEQUENCING HAPLOTYPES SOUTH AMERICA Y CHROMOSOME