The noncanonical role of EZH2 in cancer.
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of polycomb repressive complex 2 (PRC2). Dysregulation of EZH2 causes alteration of gene expression and functions, thereby promoting cancer development. The regulatory function of EZH2 varies across different tumor types. The canonical role of EZH2 is gene silencing through catalyzing the trimethylation of lysine 27 of histone H3 (H3K27me3) in a PRC2-dependent manner. Accumulating evidence indicates that EZH2 has an H3K27me3-independent function as a transcriptional coactivator and plays a critical role in cancer initiation, development, and progression. In this review, we summarize the regulation and function of EZH2 and focus on the current understanding of the noncanonical role of EZH2 in cancer.
['Huang|Jinhua|J|', 'Gou|Hongwei|H|', 'Yao|Jia|J|', 'Yi|Kaining|K|', 'Jin|Zhigang|Z|', 'Matsuoka|Masao|M|https://orcid.org/0000-0002-0473-754X', 'Zhao|Tiejun|T|https://orcid.org/0000-0002-8266-8076']
D000818:Animals D000071221:Enhancer of Zeste Homolog 2 Protein D015870:Gene Expression D020868:Gene Silencing D006657:Histones D006801:Humans D009369:Neoplasms D063151:Polycomb Repressive Complex 2
EZH2 cancer PRC2 H3K27me3 carcinogenesis