Direct Cardiac Cellular Reprogramming for Cardiac Regeneration.
Direct cardiac cellular reprogramming of endogenous cardiac fibroblasts directly into induced cardiomyocytes is a highly feasible, promising therapeutic option for patients with advanced heart failure. The most successful cardiac reprogramming strategy will likely be a multimodal approach involving an optimal combination of cardio-differentiating factors, suppression of fibroblast gene expression, and induction of angiogenic factors.
['Patel|Vivekkumar|V|', 'Mathison|Megumi|M|', 'Singh|Vivek P|VP|', 'Yang|Jianchang|J|', 'Rosengart|Todd K|TK|']
Reprogramming Cardiomyocyte Heart failure GMT Gene therapy Transdifferentiation