Regulation of the Development and Function of B Cells by ZBTB Transcription Factors.
The large ZBTB family comprises a diverse group of transcriptional factors. Several ZBTB proteins have emerged as critical factors that regulate the lineage commitment, differentiation, and function of lymphoid cells as well as many other developmental events. For instance, dysfunctions of ZBTB20 or ZBTB24 have been linked to multisystem failures in humans. Within the B-cell lineage, BCL6, ZBTB7A, ZBTB17, and ZBTB1 regulate the development/differentiation of B cells in both bone marrow and peripheral lymphoid organs, while ZBTB20 and ZBTB32 seem to mainly impact the maintenance of terminal plasma cells. Given the importance of B cells in the prevention and treatment of infectious or autoimmune disorders, we herein summarize the roles of seven ZBTB family members (BCL6, ZBTB7A, ZBTB17, ZBTB20, ZBTB32, ZBTB1, and ZBTB24) in the development, differentiation, and function of B cells as well as the underlying molecular mechanisms.
['Zhu|Can|C|', 'Chen|Ge|G|', 'Zhao|Ying|Y|', 'Gao|Xiao-Ming|XM|', 'Wang|Jun|J|']
D000818:Animals D001402:B-Lymphocytes D015415:Biomarkers D002454:Cell Differentiation D004268:DNA-Binding Proteins D005786:Gene Expression Regulation D006801:Humans D005810:Multigene Family D014157:Transcription Factors D016335:Zinc Fingers
B cells ZBTB20 ZBTB24 BCL6 ZBTB7A ZBTB17 ZBTB1 ZBTB32