De novo aneurysms in long-term follow-up computed tomographic angiography of patients with clipped intracranial aneurysms.
OBJECTIVE
This study was undertaken to evaluate de novo aneurysm formation in the long-term follow-up of patients with clipped aneurysms.


METHODS
Of 459 patients who underwent clipping of ruptured cerebral aneurysms at our institution between 1997 and 2008, 119 patients were available in good condition and agreed to undergo 64-detector row computed tomographic (CT) angiography. In addition, eight patients underwent CT angiography for new subarachnoid hemorrhage.


RESULTS
The mean ± standard deviation interval from surgery was 7.2 ± 2.3 years for CT angiography controlled patients. De novo aneurysms were detected in 5 of 119 (4.5%) patients and 4 of 8 patients with new subarachnoid hemorrhage. A history of multiple aneurysms was associated with de novo aneurysm formation (P < 0.001).


CONCLUSION
The risk of de novo aneurysm formation in patients with clipped aneurysms is significant in long-term follow-up. CT angiography can be used as a noninvasive method for detection of de novo aneurysms in these patients.
['Zali|Alireza|A|', 'Khoshnood|Reza Jalili|RJ|', 'Zarghi|Afsaneh|A|']
D000293:Adolescent D000328:Adult D000368:Aged D017542:Aneurysm, Ruptured D002533:Cerebral Angiography D005260:Female D005500:Follow-Up Studies D006801:Humans D002532:Intracranial Aneurysm D008297:Male D008875:Middle Aged D019635:Neurosurgical Procedures D011183:Postoperative Complications D012008:Recurrence D013345:Subarachnoid Hemorrhage D013525:Surgical Instruments D013997:Time Factors D014057:Tomography, X-Ray Computed D055815:Young Adult
De novo aneurysm Cerebral aneurysm CT angiography Surgical clipping