Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008.
Two new isomeric modified tripeptides, aspergillamides C and D (compounds 1 and 2), together with fifteen known compounds (compounds 3-17), were obtained from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008. The structures of the new compounds, including absolute configurations, were determined by extensive analyses of spectroscopic data (NMR, MS, UV, and IR) and comparisons between the calculated and experimental electronic circular dichroism (ECD) spectra. Butyrolactone I (compound 11) exhibited strong inhibitory effects against Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) with the IC50 being 5.11 ± 0.53 μmol·L-1, and acted as a noncompetitive inhibitor based on kinetic analysis.
['Luo|Xiao-Wei|XW|', 'Lin|Yun|Y|', 'Lu|Yong-Jun|YJ|', 'Zhou|Xue-Feng|XF|', 'Liu|Yong-Hong|YH|']
D015107:4-Butyrolactone D000818:Animals D001230:Aspergillus D002623:Chemistry Techniques, Analytical D004151:Dipeptides D004791:Enzyme Inhibitors D007211:Indoles D015394:Molecular Structure D009169:Mycobacterium tuberculosis D010455:Peptides D061065:Polyketides D011161:Porifera D017027:Protein Tyrosine Phosphatases
Polyketides Aspergillus terreus Aspergillamides MptpB inhibitor