A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics.
BACKGROUND
The coronary risk in diabetes (CoRDia) trial (n = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including genetics), on clinical and behavioural outcomes. Here we present an assessment of randomisation, the cardiac risk genotyping assay, and the genetic characteristics of the recruits.


METHODS
Ten-year coronary heart disease (CHD) risk was calculated using the UKPDS score. Genetic CHD risk was determined by genotyping 19 single nucleotide polymorphisms (SNPs) using Randox's Cardiac Risk Prediction Array and calculating a gene score (GS). Accuracy of the array was assessed by genotyping a subset of pre-genotyped samples (n = 185).


RESULTS
Overall, 10-year CHD risk ranged from 2-72 % but did not differ between the randomisation groups (p = 0.13). The array results were 99.8 % concordant with the pre-determined genotypes. The GS did not differ between the Caucasian participants in the CoRDia SMI plus risk group (n = 66) (p = 0.80) and a sample of UK healthy men (n = 1360). The GS was also associated with LDL-cholesterol (p = 0.05) and family history (p = 0.03) in a sample of UK healthy men (n = 1360).


CONCLUSIONS
CHD risk is high in this group of T2D subjects. The risk array is an accurate genotyping assay, and is suitable for estimating an individual's genetic CHD risk. Trial registration This study has been registered at ClinicalTrials.gov; registration identifier NCT01891786.
['Beaney|Katherine E|KE|', 'Ward|Claire E|CE|', 'Bappa|Dauda A S|DA|', 'McGale|Nadine|N|', 'Davies|Anna K|AK|', 'Hirani|Shashivadan P|SP|', 'Li|KaWah|K|', 'Howard|Philip|P|', 'Vance|Dwaine R|DR|', 'Crockard|Martin A|MA|', 'Lamont|John V|JV|', 'Newman|Stanton|S|', 'Humphries|Steve E|SE|']
D000328:Adult D000368:Aged D016022:Case-Control Studies D003324:Coronary Artery Disease D003924:Diabetes Mellitus, Type 2 D003925:Diabetic Angiopathies D005260:Female D020869:Gene Expression Profiling D056726:Genetic Association Studies D005819:Genetic Markers D020022:Genetic Predisposition to Disease D006801:Humans D008297:Male D008875:Middle Aged D020411:Oligonucleotide Array Sequence Analysis D010641:Phenotype D020641:Polymorphism, Single Nucleotide D057285:Precision Medicine D011237:Predictive Value of Tests D011247:Pregnancy D018570:Risk Assessment D012307:Risk Factors D013997:Time Factors D006113:United Kingdom
Coronary heart disease Gene score Type 2 diabetes UKPDS score Risk prediction