Simple nomogram based on initial laboratory data for predicting the probability of ICU transfer of COVID-19 patients: Multicenter retrospective study.
This retrospective, multicenter study investigated the risk factors associated with intensive care unit (ICU) admission and transfer in 461 adult patients with confirmed coronavirus disease 2019 (COVID-19) hospitalized from 22 January to 14 March 2020 in Hunan, China. Outcomes of ICU and non-ICU patients were compared, and a simple nomogram for predicting the probability of ICU transfer after hospital admission was developed based on initial laboratory data using a Cox proportional hazards regression model. Differences in laboratory indices were observed between patients admitted to the ICU and those who were not admitted. Several independent predictors of ICU transfer in COVID-19 patients were identified including older age (≥65 years) (hazard ratio [HR] = 4.02), hypertension (HR = 2.65), neutrophil count (HR = 1.11), procalcitonin level (HR = 3.67), prothrombin time (HR = 1.28), and D-dimer level (HR = 1.25). The lymphocyte count and albumin level were negatively associated with mortality (HR = 0.08 and 0.86, respectively). The developed model provides a means for identifying, at hospital admission, the subset of patients with COVID-19 who are at high risk of progression and would require transfer to the ICU within 3 and 7 days after hospitalization. This method of early patient triage allows a more effective allocation of limited medical resources.
['Zeng|Zihang|Z|', 'Ma|Yiming|Y|', 'Zeng|Huihui|H|', 'Huang|Peng|P|', 'Liu|Wenlong|W|', 'Jiang|Mingyan|M|', 'Xiang|Xudong|X|', 'Deng|Dingding|D|', 'Liao|Xin|X|', 'Chen|Ping|P|', 'Chen|Yan|Y|0000-0002-7713-6913']
D000328:Adult D000368:Aged D000086382:COVID-19 D002681:China D005260:Female D017052:Hospital Mortality D006760:Hospitalization D006801:Humans D007362:Intensive Care Units D007753:Laboratories D008297:Male D008875:Middle Aged D049451:Nomograms D012189:Retrospective Studies D012307:Risk Factors D000086402:SARS-CoV-2
nomogram ICU transfer COVID-19 laboratory examination