Ventilator-induced Lung Injury.
Prevention of ventilator-induced lung injury (VILI) can attenuate multiorgan failure and improve survival in at-risk patients. Clinically significant VILI occurs from volutrauma, barotrauma, atelectrauma, biotrauma, and shear strain. Differences in regional mechanics are important in VILI pathogenesis. Several interventions are available to protect against VILI. However, most patients at risk of lung injury do not develop VILI. VILI occurs most readily in patients with concomitant physiologic insults. VILI prevention strategies must balance risk of lung injury with untoward side effects from the preventive effort, and may be most effective when targeted to subsets of patients at increased risk.
['Beitler|Jeremy R|JR|', 'Malhotra|Atul|A|', 'Thompson|B Taylor|BT|']
D006801:Humans D055370:Lung Injury D012128:Respiratory Distress Syndrome D015656:Respiratory Mechanics D055397:Ventilator-Induced Lung Injury
Ventilator-induced lung injury Acute lung injury Acute respiratory distress syndrome Mechanical ventilation Respiratory mechanics