Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer.
AIM
To evaluate the association between of the interleukin-10 (IL-10) promoter polymorphisms and survival of advanced gastric cancer (GC) patients.


METHODS
The IL-10 (-1082, rs1800896; -819, rs1800871; and-592, rs1800896) genotypes in 234 patients with advanced gastric cancer and in 243 healthy controls were determined by polymerase chain reaction-restriction fragment length polymorphism assay. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by unconditional logistic regression for the associations between IL-10 genotypes and the risk of GC. The Kaplan-Meier method with log-rank testing was used to evaluate the association between genotype and survival of the patients.


RESULTS
The IL-10 -1082 G allele and GCC (-1082, -819 and -592) haplotype were associated with increased gastric cancer risks (OR 1.2, 95% CI 0.6-3.2, P = 0.007, for -1082 G allele, OR = 2.3, 95% CI, 1.2-4.1, P = 0.005, for GCC haplotype, respectively). However, none of the three IL-10 gene polymorphisms (-1082, -819 and -592) was correlated with gastric cancer survival (P > 0.05), and none of the genotypes of the three IL-10 sites was found as independent prognostic risk factors in the multivariate test.


CONCLUSION
IL-10 gene promoter polymorphisms may not be associated with the prognosis of advanced gastric cancer.
['Liu|Jie|J|', 'Song|Bao|B|', 'Wang|Jia-Lin|JL|', 'Li|Zeng-Jun|ZJ|', 'Li|Wan-Hu|WH|', 'Wang|Zhe-Hai|ZH|']
D000328:Adult D000368:Aged D000483:Alleles D005260:Female D006239:Haplotypes D006801:Humans D016753:Interleukin-10 D008297:Male D008875:Middle Aged D015999:Multivariate Analysis D011110:Polymorphism, Genetic D011379:Prognosis D011401:Promoter Regions, Genetic D012044:Regression Analysis D012307:Risk Factors D013274:Stomach Neoplasms D016896:Treatment Outcome
Interleukin-10 Prognosis Gastric cancer Cytokine Genetic polymorphism