HIV-associated Non-small-cell Lung Cancer with Rearrangement of the Anaplastic Lymphoma Kinase Gene: A Report of Two Patients.
Non-small-cell lung cancer (NSCLC) is the most common non-AIDS defining cancer in patients infected with HIV and has the highest mortality rate among all cancers in this patient population. Treatment of NSCLC in HIV-positive patients is similar to that in HIV-negative patients, but less is known about the molecular characteristics of NSCLC in HIV-positive patients. This report describes two patients with HIV-associated NSCLC and rearrangements of the anaplastic lymphoma kinase (ALK) gene. The disease followed an indolent course in both patients.
['Pichardo|Rayli|R|', 'Go|Rafael Francisco|RF|', 'Qu|Lang|L|', 'Hussein|Lily|L|', 'Gupta|Shweta|S|']
alk-positive adenocarcinoma hiv infection non-small cell lung cancer