Decreased serum level of lipoprotein cholesterol is a poor prognostic factor for patients with severe community-acquired pneumonia that required intensive care unit admission.
PURPOSE
The purpose of this study is to investigate the prognostic values of the serum levels of lipids in patients with severe community-acquired pneumonia (CAP) that required intensive care unit (ICU) admission.


MATERIALS AND METHODS
Patients who had severe CAP that required ICU admission were included. Serum lipid level was collected on the days 1 and 7 of ICU stay. Clinical outcome, including length of ICU stay, hospital stay, and death, were monitored prospectively.


RESULTS
A total of 40 patients were enrolled in this study. Lower high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were found in nonsurvival group on ICU admission day 7 (survivors vs nonsurvivors; mean HDL, 41.8 vs 13.0 mg/dL, P = .002; LDL, 62.3 vs 30.3 mg/dL, P = 0.006, respectively). High-density lipoprotein cholesterol level of less than or equal to 17 mg/dL on day 7 (odds ratio, 1.23) and LDL cholesterol level of less than or equal to 21 mg/dL on day 7 (odds ratio, 1.10) could be a predictor of hospital mortality. The mean change in levels of HDL cholesterol in nonsurvivors decreased significantly than those in survivors from days 1 to 7 (8.5 vs -17.4 mg/dL, P = .04) but not LDL cholesterol.


CONCLUSIONS
Decreased serum HDL cholesterol level from days 1 to 7 may be of prognostic value.
['Chien|Yu-Fen|YF|', 'Chen|Chung-Yu|CY|', 'Hsu|Chia-Lin|CL|', 'Chen|Kuan-Yu|KY|', 'Yu|Chong-Jen|CJ|']
D000368:Aged D000369:Aged, 80 and over D008076:Cholesterol, HDL D008078:Cholesterol, LDL D015331:Cohort Studies D017714:Community-Acquired Infections D018450:Disease Progression D005260:Female D017052:Hospital Mortality D006801:Humans D007362:Intensive Care Units D007902:Length of Stay D008297:Male D008875:Middle Aged D011014:Pneumonia D011379:Prognosis D011446:Prospective Studies
Lipoprotein Cholesterol Pneumonia Critical care