Intestinal Flora Dysbiosis Aggravates Cognitive Dysfunction Associated With Neuroinflammation in Heart Failure.
BACKGROUND
Cognitive dysfunction after heart failure (HF) is characterized by neuroinflammation, which plays an important role in the occurrence and development of cognitive dysfunction. Recent studies have shown that an intestinal flora imbalance may also trigger neuroinflammation in Alzheimer's disease. The present study was designed to reveal that intestinal flora dysbiosis caused by HF aggravates neuroinflammation-associated cognitive impairment.


METHODS AND RESULTS
Adult male Sprague-Dawley rats were fed daily for 2 weeks with probiotics or placebo until the day of surgery. HF was then triggered by 8 weeks of sustained coronary artery occlusion. 16S rDNA sequencing was used to confirm intestinal flora dysbiosis after HF and demonstrate that the changes paralleled intestinal pathology scores. The permeability of the blood-brain barrier was increased after HF, and such an increase in permeability may increase the levels of inflammatory cytokines caused by intestinal flora disorders. The changes in the intestinal flora caused by probiotics significantly reduced the level of neuroinflammation. In addition, probiotic administration considerably improved the impaired spatial memory in HF rats.


CONCLUSIONS
We conclude that intestinal flora dysbiosis plays a potential role in aggravating the impaired cognition associated with neuroinflammation and that these effects may be attenuated by probiotics.
['Yu|Wei|W|', 'Gao|Dapeng|D|', 'Jin|Wen|W|', 'Wang|Zijian|Z|', 'Li|Yan|Y|', 'Peng|Xiaowei|X|', 'Cong|Yushuang|Y|', 'Li|Chenglong|C|', 'Zhao|Ayang|A|', 'Liu|Shuai|S|', 'Qi|Sihua|S|']
D000818:Animals D060825:Cognitive Dysfunction D064806:Dysbiosis D000069196:Gastrointestinal Microbiome D006333:Heart Failure D008297:Male D019936:Probiotics D051381:Rats D017207:Rats, Sprague-Dawley
cognition neuroinflammation Heart failure microbiome