Airborne polycyclic aromatic hydrocarbons trigger human skin cells aging through aryl hydrocarbon receptor.
Accumulating evidence suggests that polycyclic aromatic hydrocarbons (PAH) which adsorbed on the surface of ambient air particulate matters (PM), are the major toxic compound to cause cardiovascular and respiratory diseases, even cancer. However, its detrimental effects on human skin cell remain unclear. Here, we demonstrated that SRM1649b, a reference urban dust material of PAH, triggers human skin cells aging through cell cycle arrest, cell growth inhibition and apoptosis. Principally, SRM1649b facilitated Aryl hydrocarbon receptor (AhR) translocated into nucleus, subsequently activated ERK/MAPK signaling pathway, and upregulated aging-related genes expression. Most important, we found that AhR antagonist efficiently revert the aging of skin cells. Thus our novel findings firstly revealed the mechanism of skin aging under PAH contamination and provided potential strategy for clinical application.
['Qiao|Yuan|Y|', 'Li|Qiang|Q|', 'Du|Hong-Yang|HY|', 'Wang|Qiao-Wei|QW|', 'Huang|Ye|Y|', 'Liu|Wei|W|']
D017209:Apoptosis D059447:Cell Cycle Checkpoints D049109:Cell Proliferation D002478:Cells, Cultured D004305:Dose-Response Relationship, Drug D006801:Humans D015603:Keratinocytes D011084:Polycyclic Aromatic Hydrocarbons D018336:Receptors, Aryl Hydrocarbon D015595:Skin Aging D013329:Structure-Activity Relationship
Polycyclic aromatic hydrocarbons Skin cell aging Aryl hydrocarbon receptor MAPK signaling pathway Aging-related genes Clinical applications