Relapsing-remitting multiple sclerosis: A profile of interleukine-1 gene cluster polymorphisms in Iraqi patients.
In this case-control study, 68 relapsing-remitting multiple sclerosis (RRMS) patients and 133 control were genotyped for IL1A-889 (rs1800587), IL1B-511 (rs16944), IL1B+3962 (rs1143634), IL1R1pst11970 (rs2234650) and IL1RNmspa1 11,100 (rs315952) variants. Sequence-specific-primer-polymerase-chain-reaction was the genotyping method. Logistic regression analysis demonstrated protective effects of IL1B-511, IL1R1pst11970 and IL1RNmspa1 11,100 against MS incidence, while no association was found with IL1A-889 and IL1B+3962 variants. Allele frequencies showed no significant gender, medication or expanded disability status scale-associated variation. Haplotype analysis suggested 4.31-fold increased odds for MS in subjects with C-T-C-C-T haplotype of the respective loci. In conclusion, IL-1 gene variants influence MS susceptibility in Iraqi population.
['Al-Naseri|Milad A S|MAS|', 'Salman|Ehab D|ED|', "Ad'hiah|Ali H|AH|"]
Relapsing-remitting multiple sclerosis Logistic regression analysis Haplotype Intrleukin-1 Single nucleotide polymorphisms