Dengue infection in pregnancy and transplacental transfer of anti-dengue antibodies in Northeast, Brazil.
BACKGROUND
Dengue affects nearly 400 million people annually worldwide and considered one of the most serious health threats in tropical and subtropical countries.


OBJECTIVE
To analyze the occurrence of dengue infection among the parturient who have formed the baseline of an ongoing birth cohort study in the city of Recife, Northeast of Brazil.


STUDY DESIGN
From March 2011 to May 2012, we recruited 417 parturients with low-risk pregnancies at maternity ward who agreed to a follow-up of their babies. Dengue infection was accessed through DENV RT-PCR and anti-dengue antibodies (IgM and IgG). The prevalence of IgG antibodies in the parturients and their concepts were determined. The concordance among the pairs was tested using Kappa. The association of recent infection (IgM and/or DENV RT-PCR positive) with the maternal characteristics and clinical features of the neonates was analyzed through logistic regression.


RESULTS
The prevalence of IgG antibodies in the maternal and cord blood samples was 95.1% (95% CI: 92.6-96.9%) and 95.8% (95% CI: 93.4-97.5%), respectively, with high agreement between maternal-cord pairs (Kappa=0.93). The prevalence of recent infection was 10.6% (95% CI: 7.9-14.2%) in the parturients. Reported fever during pregnancy was associated to recent infection (p=0.023).


CONCLUSION
The data draw attention for the high frequency of anti-dengue antibodies in the women studied and for the high occurrence of infection during pregnancy in this region of Brazil. There is a need for further studies to better characterize dengue infection in pregnant women.
['Leite|Rachel C|RC|', 'Souza|Ariani I|AI|', 'Castanha|Priscila M S|PM|', 'Cordeiro|Marli T|MT|', 'Martelli|Celina T|CT|', 'Ferreira|Ana Laura G|AL|', 'Katz|Leila|L|', 'Braga|Cynthia|C|']
D000293:Adolescent D000328:Adult D000914:Antibodies, Viral D001938:Brazil D002648:Child D003715:Dengue D005260:Female D005312:Fetal Blood D006801:Humans D007074:Immunoglobulin G D007075:Immunoglobulin M D007231:Infant, Newborn D008297:Male D008431:Maternal-Fetal Exchange D011247:Pregnancy D011251:Pregnancy Complications, Infectious D055815:Young Adult
Pregnancy Prevalence Dengue virus Epidemiology Vertical infectious