S-Adenosyl-l-Methionine Overcomes uL3-Mediated Drug Resistance in p53 Deleted Colon Cancer Cells.
PURPOSE
In order to study novel therapeutic approaches taking advantage of natural compounds showing anticancer and anti-proliferative effects, we focused our interest on S-adenosyl-l-methionine, a naturally occurring sulfur-containing nucleoside synthesized from adenosine triphosphate and methionine by methionine adenosyltransferase, and its potential in overcoming drug resistance in colon cancer cells devoid of p53.


RESULTS
In the present study, we demonstrated that S-adenosyl-l-methionine overcomes uL3-mediated drug resistance in p53 deleted colon cancer cells. In particular, we demonstrated that S-adenosyl-l-methionine causes cell cycle arrest at the S phase; inhibits autophagy; augments reactive oxygen species; and induces apoptosis in these cancer cells.


CONCLUSIONS
Results reported in this paper led us to propose S-adenosyl-l-methionine as a potential promising agent for cancer therapy by examining p53 and uL3 profiles in tumors to yield a better clinical outcomes.
['Mosca|Laura|L|', 'Pagano|Martina|M|', 'Pecoraro|Annalisa|A|', 'Borzacchiello|Luigi|L|', 'Mele|Luigi|L|', 'Cacciapuoti|Giovanna|G|', 'Porcelli|Marina|M|0000-0003-0192-1728', 'Russo|Giulia|G|', 'Russo|Annapina|A|0000-0002-7509-3702']
D003110:Colonic Neoplasms D019008:Drug Resistance, Neoplasm D017353:Gene Deletion D045325:HCT116 Cells D006801:Humans D000090822:Ribosomal Protein L3 D012269:Ribosomal Proteins D012436:S-Adenosylmethionine D016159:Tumor Suppressor Protein p53
drug resistance colon cancer autophagy apoptosis uL3 AdoMet