Prevention of Tamoxifen-related Nonalcoholic Fatty Liver Disease in Breast Cancer Patients.
BACKGROUND
Tamoxifen is commonly used to prevent breast cancer recurrence. Studies have confirmed the association between tamoxifen and nonalcoholic fatty liver disease (NAFLD), with the results indicating the need for aggressive management of this side effect. We assessed the potential risk factors for and identified the possible protective factors of tamoxifen-related fatty liver.


MATERIALS AND METHODS
We enrolled patients with a history of breast cancer, aged 20 to 70 years, who had received with tamoxifen treatment within the past 5 years. We obtained the initial data and performed a follow-up blood test and ultrasound examination to compare the differences before and after tamoxifen treatment. The patients were divided into relatively normal and fatty liver groups.


RESULTS
Of the 266 enrolled tamoxifen-treated patients, 143 (53.8%) and 123 (46.2%) were in the relatively normal and fatty liver groups, respectively. The initial body weight (57.6 ± 9.3 kg vs. 60.9 ± 10.3 kg; P = .006) and body mass index (BMI; 23.4 ± 3.8 kg/m2 vs. 25.0 ± 4.2 kg/m2; P < .001) were lower in the relatively normal group. An initial BMI of ≥ 22 kg/m2 was a potential risk factor for tamoxifen-related NAFLD (hazard ratio [HR], 1.58; 95% confidence interval [CI], 1.00-2.48; P = .048). In contrast, a weekly exercise duration of ≥ 150 minutes reduced the risk (HR, 0.47; 95% CI, 0.31-0.69; P < .001).


CONCLUSION
The results from our study suggest that a BMI of ≥ 22 kg/m2 is a potential risk factor for tamoxifen-related fatty liver and exercise is a possible protective factor.
['Chang|Hong-Tai|HT|', 'Pan|Hsiang-Ju|HJ|', 'Lee|Chien-Hung|CH|']
D000328:Adult D000368:Aged D018931:Antineoplastic Agents, Hormonal D015992:Body Mass Index D001943:Breast Neoplasms D015444:Exercise D005260:Female D005500:Follow-Up Studies D006801:Humans D008875:Middle Aged D065626:Non-alcoholic Fatty Liver Disease D012307:Risk Factors D013629:Tamoxifen D055815:Young Adult
Nonalcoholic fatty liver Breast cancer Tamoxifen Exercise Lifestyle