Synthesis and evaluation of novel prenylated chalcone derivatives as anti-leishmanial and anti-trypanosomal compounds.
Chalcones form a class of compounds that belong to the flavonoid family and are widely distributed in plants. Their simple structure and the ease of preparation make chalcones attractive scaffolds for the synthesis of a large number of derivatives enabling the evaluation of the effects of different functional groups on biological activities. In this Letter, we report the successful synthesis of a series of novel prenylated chalcones via Claisen-Schmidt condensation and the evaluation of their effect on the viability of the Trypanosomatidae parasites Leishmania amazonensis, Leishmania infantum and Trypanosoma cruzi.
['Passalacqua|Thais Gaban|TG|', 'Dutra|Luiz Antonio|LA|', 'de Almeida|Letícia|L|', 'Velásquez|Angela Maria Arenas|AM|', 'Torres|Fabio Aurelio Esteves|FA|', 'Yamasaki|Paulo Renato|PR|', 'dos Santos|Mariana Bastos|MB|', 'Regasini|Luis Octavio|LO|', 'Michels|Paul A M|PA|', 'Bolzani|Vanderlan da Silva|Vda S|', 'Graminha|Marcia A S|MA|']
D002599:Chalcone D020128:Inhibitory Concentration 50 D018314:Leishmania infantum D054876:Prenylation D013329:Structure-Activity Relationship D014344:Trypanocidal Agents D014349:Trypanosoma cruzi
Prenylated chalcone Leishmania amazonensis Leishmania infantum Trypanosoma cruzi Drug discovery Leishmanicidal activity Trypanocidal activity