Potent antimicrobial activity of bone cement encapsulating silver nanoparticles capped with oleic acid.
Bone cement is widely used in surgical treatments for the fixation for orthopaedic devices. Subsequently, 2-3% of patients undergoing these procedures develop infections that are both a major health risk for patients and a cost for the health service providers; this is also aggravated by the fact that antibiotics are losing efficacy because of the rising resistance of microorganisms to these substances. In this study, oleic acid capped silver nanoparticles (NP) were encapsulated into Poly(methyl methacrylate) (PMMA)-based bone cement samples at various ratios. Antimicrobial activity against Methicillin Resistant Staphylococcus aureus, S. aureus, Staphylococcus epidermidis, Acinetobacter baumannii was exhibited at NP concentrations as low as 0.05% (w/w). Furthermore, the mechanical properties and cytotoxicity of the bone cement containing these NP were assessed to guarantee that such material is safe to be used in orthopaedic surgical practice.
['Prokopovich|Polina|P|', 'Köbrick|Mathias|M|', 'Brousseau|Emmanuel|E|', 'Perni|Stefano|S|']
D000818:Animals D001843:Bone Cements D002460:Cell Line D004305:Dose-Response Relationship, Drug D006094:Gram-Positive Bacteria D053768:Metal Nanoparticles D051379:Mice D019301:Oleic Acid D013211:Staphylococcus aureus
antimicrobial bone cement silver nanoparticles PMMA nanoindentation