Immunoglobulin E-mediated hypersensitivity reaction after intraperitoneal administration of vancomycin.
Intraperitoneal (IP) vancomycin is widely used to treat Gram-positive peritonitis associated with peritoneal dialysis. There have been two cases of red man syndrome (RMS), a vancomycin-specific nonimmunologic reaction, associated with IP vancomycin. However, immune-mediated hypersensitivity reaction to IP vancomycin has not yet been reported. A 49 year old woman on continuous ambulatory peritoneal dialysis developed her first peritonitis episode. The patient was treated with IP vancomycin once/wk for 4 weeks. She experienced mild itching and flushing throughout her body for 1 day after the second treatment. Whenever vancomycin was administered, generalized urticaria and a prickling sensation developed, and the intensity increased gradually; however, these symptoms improved after vancomycin was discontinued. An allergic skin test was performed 6 weeks after the previous urticarial episode, and an intradermal skin test revealed a positive response to vancomycin. To our knowledge, this is the first case report of immunoglobulin E-mediated hypersensitivity reaction to IP vancomycin administration.
['Hwang|Mun-Ju|MJ|', 'Do|Jun-Young|JY|', 'Choi|Eun-Woo|EW|', 'Seo|Joon-Hyuk|JH|', 'Nam|Yoon-Jung|YJ|', 'Yoon|Kyung-Woo|KW|', 'Park|Jong-Won|JW|', 'Cho|Kyu-Hyang|KH|', 'Kang|Seok-Hui|SH|', 'Jin|Hyun-Jung|HJ|']
Hypersensitivity Intraperitoneal administration Vancomycin Peritoneal dialysis