Testosterone replacement therapy improves health-related quality of life for patients with late-onset hypogonadism: a meta-analysis of randomized controlled trials.
Although testosterone replacement therapy can restore serum testosterone concentrations to normal level in late-onset hypogonadism patients, whether it can improve patients' quality of life remains uncertain. Therefore, we perform a meta-analysis of randomized controlled trials on this issue. Five randomized controlled trials total 1,212 patients were included. Fixed-effect model was used to calculate the weighted mean difference of score of Aging Males' Symptom rating scale. Our result reveals that testosterone replacement therapy improves patients' health-related quality of life in terms of the decrease in the AMS total score [WMD = -2.96 (-4.21, -1.71), p < .00001] and the psychological [WMD = -0.89 (-1.41, -0.37), p = .0008], somatic [WMD = -0.89 (-1.41, -0.37), p = .0008] and sexual [WMD = -1.29 (-1.75, -0.83), p < .00001] subscale score.
['Nian|Y|Y|', 'Ding|M|M|', 'Hu|S|S|', 'He|H|H|', 'Cheng|S|S|', 'Yi|L|L|', 'Li|Y|Y|', 'Wang|Y|Y|']
D000368:Aged D000728:Androgens D020249:Hormone Replacement Therapy D006801:Humans D007006:Hypogonadism D000067562:Late Onset Disorders D008297:Male D015233:Models, Statistical D011788:Quality of Life D016032:Randomized Controlled Trials as Topic D013739:Testosterone
testosterone replacement therapy health-related quality of life late-onset hypogonadism Aging Males' Symptom rating scale testosterone deficiency