Effectiveness of Internet- and Mobile-Based Cognitive Behavioral Therapy to Reduce Suicidal Ideation and Behaviors: Protocol for a Systematic Review and Meta-Analysis of Individual Participant Data.
Internet- and mobile-based cognitive behavioral therapy (iCBT) might reduce suicidal ideation. However, recent meta-analyses found small effect sizes, and it remains unclear whether specific subgroups of participants experience beneficial or harmful effects. This is the study protocol for an individual participant meta-analysis (IPD-MA) aiming to determine the effectiveness of iCBT on suicidal ideation and identify moderators. We will systematically search CENTRAL, PsycINFO, Embase, and Pubmed for randomized controlled trials examining guided or self-guided iCBT for suicidality. All types of control conditions are eligible. Participants experiencing suicidal ideation will be included irrespective of age, diagnoses, or co-interventions. We will conduct a one-stage IPD-MA with suicidal ideation as the primary outcome, using a continuous measure, reliable improvement and deterioration, and response rate. Moderator analyses will be performed on participant-, study-, and intervention-level. Two independent reviewers will assess risk of bias and the quality of evidence using Cochrane's Risk of Bias Tool 2 and GRADE. This review was registered with OSF and is currently in progress. The IPD-MA will provide effect estimates while considering covariates and will offer novel insights into differential effects on a participant level. This will help to develop more effective, safe, and tailored digital treatment options for suicidal individuals.
['Büscher|Rebekka|R|0000-0001-8931-0942', 'Beisemann|Marie|M|0000-0001-6977-167X', 'Doebler|Philipp|P|0000-0002-2946-8526', 'Steubl|Lena|L|0000-0002-8508-5271', 'Domhardt|Matthias|M|', 'Cuijpers|Pim|P|0000-0001-5497-2743', 'Kerkhof|Ad|A|', 'Sander|Lasse B|LB|']
D015928:Cognitive Behavioral Therapy D006801:Humans D020407:Internet D015201:Meta-Analysis as Topic D059020:Suicidal Ideation D000078202:Systematic Reviews as Topic
mobile-based cognitive behavioral therapy suicidal ideation suicide review iCBT individual participant data meta-analysis internet-based online