Interstitial lung abnormalities: erecting fences in the path towards advanced pulmonary fibrosis.
Interstitial lung abnormalities, when present in members of undiagnosed family members recruited on the basis of familial interstitial pneumonia, or in undiagnosed research participants, have been associated with a syndrome that includes distinct sets of imaging abnormalities, restrictive physiological and exercise impairments, and an increased prevalence of histopathological findings, and genetic predictors, that have been noted in patients with idiopathic pulmonary fibrosis. Recent longitudinal studies have demonstrated that qualitative and quantitative assessments of interstitial abnormalities are associated with accelerated lung function decline, an increased rate of clinical diagnoses of interstitial lung disease and an increased rate of mortality. In this perspective, in addition to reviewing the prior information, four major efforts that could help the field of early pulmonary fibrosis detection move forward are discussed. These efforts include: (1) developing standards for characterising and reporting imaging findings from patients with existing CTs; (2) developing consensus statements on when undiagnosed and asymptomatic imaging abnormalities should be considered a disease; (3) identifying populations for which screening efforts might be beneficial; and (4) considering approaches to developing effective secondary prevention trials.
['Hunninghake|Gary M|GM|']
D001706:Biopsy D003937:Diagnosis, Differential D014943:Global Health D006801:Humans D054990:Idiopathic Pulmonary Fibrosis D008168:Lung D017563:Lung Diseases, Interstitial D015995:Prevalence D014057:Tomography, X-Ray Computed
idiopathic pulmonary fibrosis ARDS clinical epidemiology imaging/CT MRI etc interstitial fibrosis