Relation of intrathecal oligoclonal band production to inflammatory mediator and immunotherapy response in 208 children with OMS.
In 208 children with opsoclonus-myoclonus syndrome (OMS), CSF IgG oligoclonal bands (OCB) and 22 immunomarkers in CSF and 21 in serum/blood were measured. In 36 untreated OMS, 58% were OCB(+), whereas 55% of treated OMS were OCB(-). OCB positivity or negativity did not alter concentrations or frequencies of immunomarkers. The phenotypes of OCB(+) and OCB(-) patients were not distinctive. CSF B cells were expanded in untreated OMS regardless of OCB positivity. These data reveal a much higher frequency of OCB positivity in untreated OMS than previously realized and a disconnect between intrathecal OCB and inflammatory mediator production.
['Pranzatelli|Michael R|MR|', 'McGee|Nathan R|NR|', 'Tate|Elizabeth D|ED|']
D015415:Biomarkers D016022:Case-Control Studies D002648:Child D002675:Child, Preschool D015331:Cohort Studies D005260:Female D006801:Humans D007155:Immunologic Factors D007167:Immunotherapy D018836:Inflammation Mediators D008297:Male D043025:Oligoclonal Bands D053578:Opsoclonus-Myoclonus Syndrome D012189:Retrospective Studies D016896:Treatment Outcome
Opsoclonus-myoclonus syndrome CSF B cells CSF chemokines Neuroblastoma Neuroinflammation Paraneoplastic disorders Pediatric neuroinflammatory disorders