Influence of surgical site infection on oncological prognosis after curative resection for colorectal cancer: An observational single-institution study.
BACKGROUND
An exacerbated inflammatory response to post-operative infection could favor an environment in which residual viable tumor cells present in the surgical bed, bloodstream, or occult micrometastases can survive and progress to produce local or distant recurrence. In this regard, a surgical site infection (SSI) could be an important risk factor for disease progression. This study aimed to investigate the impact of SSI on long-term survival and recurrence of colorectal cancer.


METHODS
Patients who underwent curative-intent resection for colorectal carcinoma between 2011 and 2013 were retrospectively analyzed. Overall and disease-free survival (DFS) and local recurrence rate for patients with and without SSI were analyzed.


RESULTS
One hundred and thirty-eight patients were included in the study. Fifty-one (37%) patients showed SSI but revealed no differences in recurrence rate and overall survival compared with non-infected patients. However, the stratified analysis revealed that patients with an intra-abdominal abscess or an organ-space-infection showed a higher recurrence rate and a decreased 5-year overall and DFS.


CONCLUSIONS
SSI may have an influence on the oncological prognosis and, therefore, could be considered a recurrence factor. Further multi-institutional studies are necessary to conclude a causal association.
['Lorente-Herce|José M|JM|', 'Parra-Membrives|Pablo|P|', 'Martínez-Baena|Darío|D|', 'Cañete-Gómez|Jesús|J|', 'Segura-Sampedro|Juan J|JJ|']
D015179:Colorectal Neoplasms D018572:Disease-Free Survival D006801:Humans D009364:Neoplasm Recurrence, Local D011379:Prognosis D012189:Retrospective Studies D013530:Surgical Wound Infection
Surgical site infection Oncological prognosis Colorectal cancer Cáncer colorrectal Infección de sitio quirúrgico Pronóstico oncológico