Post-mastectomy radiation therapy in breast cancer with 1-3 involved lymph nodes: the Pros.
In 2014, the Early Breast Cancer Trialists' Collaborative Group (EBCTCG) reported that post-mastectomy radiation therapy (PMRT) for breast cancer patients with 1-3 cancer-positive lymph nodes is associated with a survival benefit. However, it is not known whether this applies to Japanese patients in daily clinical practice, because this conclusion was based on the results of older, western trials. Therefore, we studied the differences between PMRT results in western breast cancer patients and current practice in Japanese patients. Although we identified three differences, they do not appear to strongly impact the results of EBCTCG. We conclude that Japanese breast cancer patients with 1-3 positive lymph nodes should receive PMRT in daily clinical practice.
['Tada|Keiichiro|K|http://orcid.org/0000-0002-5395-986X', 'Nishioka|Kotoe|K|', 'Kikuchi|Yasuko|Y|', 'Niwa|Takayoshi|T|', 'Seto|Yasuyuki|Y|']
D001943:Breast Neoplasms D003131:Combined Modality Therapy D005260:Female D006801:Humans D008198:Lymph Nodes D008408:Mastectomy D015201:Meta-Analysis as Topic D009364:Neoplasm Recurrence, Local D011182:Postoperative Care D011379:Prognosis D018714:Radiotherapy, Adjuvant D021701:Sentinel Lymph Node Biopsy
Post-mastectomy radiation therapy Breast neoplasms Lymphatic Metastasis