Does bone marrow aspirate help enhance the integration of gamma irradiated allograft bone?
Bone allografts donated by other individuals offer a viable alternative to autograft. Risks of disease transmission are overcome by sterilizing the bone; unfortunately sterilization methods generally affect bone functional properties including osteogenic potential and biomechanical integrity. This study aimed to determine any enhancement effect when gamma sterilised allografts was impregnated with autologous bone marrow in improving the rate and quality of integration in metaphyseal-tibial defects of rabbits. Almost all subjects showed 50% of the defect being covered by new bones by the third week and smaller residual defect size in the treated group at the fifth week. Hounsfield units at the defect site showed increasing healing in all samples, with the treated group having an apparent advantage although insignificant (p > 0.05). In the histopathological score evaluating healing over cortical and cancellous bone at the fracture site showed only slight variations between the groups (p > 0.05). Therefore no enhanced healing by the autologous bone marrow was observed when added to the bone allografts in treating the unicortical defects.
['Thong|Fu Yuen|FY|', 'Mansor|Azura|A|', 'Ramalingam|Saravana|S|', 'Yusof|Norimah|N|']
D000818:Animals D016026:Bone Marrow Transplantation D016025:Bone Transplantation D017102:Fracture Healing D005720:Gamma Rays D008297:Male D010012:Osteogenesis D011817:Rabbits D013242:Sterilization D013977:Tibia D013978:Tibial Fractures D014182:Transplantation, Autologous D014184:Transplantation, Homologous
Bone marrow Allograft Enhancement effect Metaphyseal-tibial defects Radiation sterilization