Psychiatric comorbidities in opioid-dependent patients undergoing a replacement therapy programme in Spain: The PROTEUS study.
Opioid-dependent patients show a high rate of psychiatric comorbidities. The prevalence and characteristics of patients with dual diagnosis have not been well established in Spanish opioid agonist treatment (OAT) programmes. Thus, 621 opioid-dependent patients enrolled in OAT programmes were assessed, using the EuropASI questionnaire, for psychiatric comorbidities, which were detected in 67% of patients (anxiety 53%, mood disorders 48%, sleep disorders 41%, substance-related disorders 36%). In addition, compared with patients without a dual diagnosis, patients with dual pathology were significantly older, used benzodiazepines and cannabis in significantly greater percentages, and showed significantly more frequent infectious and non-infectious comorbidities, worse overall working status, a lower proportion of drivers and higher levels of severity regarding medical, employment, alcohol, legal, family and psychological issues. Therefore, the data showed a very high prevalence of psychiatric comorbidity in opioid-dependent patients receiving OAT in Spain and several problems frequently associated with patients with dual diagnosis. Physicians treating opioid-dependent patients should be aware of these facts to correctly identify and manage patients with a dual diagnosis.
['Roncero|Carlos|C|', 'Barral|Carmen|C|', 'Rodríguez-Cintas|Laia|L|', 'Pérez-Pazos|Jesús|J|', 'Martinez-Luna|Nieves|N|', 'Casas|Miguel|M|', 'Torrens|Marta|M|', 'Grau-López|Lara|L|']
D000328:Adult D015897:Comorbidity D017831:Diagnosis, Dual (Psychiatry) D005260:Female D006801:Humans D008297:Male D001523:Mental Disorders D008691:Methadone D008875:Middle Aged D058850:Opiate Substitution Treatment D009293:Opioid-Related Disorders D015995:Prevalence D013030:Spain D019966:Substance-Related Disorders D055815:Young Adult
Psychiatric Comorbidity Dual diagnosis Opioid agonist treatment EuropASI questionnaire Methadone Opioid dependence