Trafficking of Mycobacterium tuberculosis Envelope Components and Release Within Extracellular Vesicles: Host-Pathogen Interactions Beyond the Wall.
Components of Mycobacterium tuberculosis (Mtb) envelope such as lipoproteins, lypoglycans, lipids, and glycolipids act as Pathogen Associated Molecular Patterns and/or antigens, hence contributing in different ways to the bacillus recognition, phagocytosis, and to immune responses modulation. However, Mtb envelope components are not only encountered at the bacillus-host direct contact but can act remotely from the bacillus envelope. Indeed, they are also released from the bacillus envelope and are detected in different compartments such as the infected cells endosomal compartments or in extracellular vesicles produced by the bacillus itself or by infected cells. Characterizing their trafficking is of main importance for our understanding of their role in host-pathogen interactions and consequently for their potential use as vaccine components. This review aims at providing an overview of the current knowledge of the nature of Mtb envelope components shuttled within extracellular vesicles, the interaction of these vesicles with host immune cells and the remaining black holes.
['Layre|Emilie|E|']
D056704:Adaptive Immunity D000818:Animals D017209:Apoptosis D015415:Biomarkers D002473:Cell Wall D000067128:Extracellular Vesicles D006017:Glycolipids D054884:Host-Pathogen Interactions D006801:Humans D007113:Immunity, Innate D056747:Immunomodulation D008070:Lipopolysaccharides D008074:Lipoproteins D009169:Mycobacterium tuberculosis D021381:Protein Transport D014376:Tuberculosis
tuberculosis vesicles host-pathogen interactions lipids exosomes