Association between copeptin and declining glomerular filtration rate in people with newly diagnosed diabetes. The Skaraborg Diabetes Register.
AIMS
Copeptin has shown association with development of chronic kidney disease (CKD) in people with diabetes. Early detection of individuals having the highest risk could help avoid this complication. Therefore we decided to study copeptin concentrations and estimated glomerular filtration rate (eGFR) retrospectively in people with newly diagnosed diabetes.


METHODS
People with newly diagnosed type 2 diabetes in 1996-1998 from Skaraborg Diabetes Register (SDR) were reinvestigated in 2008-2010. Copeptin concentration at the time of diagnosis was determined. Creatinine and cystatin C were used for determination of eGFR at baseline and at reinvestigation (n=161). Data on cardiovascular complications were extracted from national registers. Analyzes were done with logistic regression.


RESULTS
From baseline to follow up eGFR decreased with 33ml. Twenty-nine individuals (18.1%) developed CKD stage 3. There was a significant association between elevated copeptin concentrations and development of CKD stage 3 (OR=1.78, 95% CI=1.01-3.16). When adjusting for GFR at baseline the association between copeptin and GFR decline was borderline significant (OR=1.79, 95% CI=0.99-3.25, p=0.055).


CONCLUSIONS
Determination of copeptin may early identify people with diabetes and high risk for CKD. To prevent complications for these individuals aggressive treatment should be discussed.
['Pikkemaat|M|M|', 'Melander|O|O|', 'Bengtsson Boström|K|K|']
D015415:Biomarkers D015331:Cohort Studies D003924:Diabetes Mellitus, Type 2 D003928:Diabetic Nephropathies D018450:Disease Progression D005260:Female D005500:Follow-Up Studies D005919:Glomerular Filtration Rate D006020:Glycopeptides D006801:Humans D007668:Kidney D008297:Male D008875:Middle Aged D011933:Reagent Kits, Diagnostic D051437:Renal Insufficiency D051436:Renal Insufficiency, Chronic D012189:Retrospective Studies D012306:Risk D013548:Sweden D015854:Up-Regulation
Copeptin Glomerular filtration rate Diabetes Chronic kidney disease Complications