Conditioning adhesive contacts between the neutrophils and the endotheliocytes by Staphylococcus aureus.
We have developed a model for evaluating the integral intercellular interactions in the "endotheliocyte-neutrophil" system and have shown the high variability of adhesion contacts in different donors associated with different expression profiles of neutrophils. Two methods (forсe spectroscopy-spectroscopy and scanning ion-conductance microscopy) showed a decrease in the rigidity of the membrane-cytoskeletal complex of neutrophils under the influence of Staphylococcus aureus 2879 M. Adding this strain to the "endotheliocyte-neutrophil" system caused a statistically significant decrease in the adhesion force and adhesion work, which indicates a change in the expression profile and physicochemical properties of membranes of both types of interacting cells (neutrophils and endotheliocytes).
['Pleskova|Svetlana N|SN|0000-0002-3415-0758', 'Kriukov|Ruslan N|RN|', 'Bobyk|Sergey Z|SZ|', 'Boryakov|Alexey V|AV|', 'Gorelkin|Peter V|PV|', 'Erofeev|Alexander S|AS|']
D000328:Adult D002448:Cell Adhesion D002450:Cell Communication D002460:Cell Line D042783:Endothelial Cells D006801:Humans D008853:Microscopy D009504:Neutrophils D013211:Staphylococcus aureus D055815:Young Adult
neutrophil endotheliocyte Staphylococcus aureus expression profile scanning ion-conducting microscopy adhesion force adhesion work FS-spectroscopy atomic-force microscopy intercellular contacts