Turning a water and oil insoluble cisplatin derivative into a nanoparticle formulation for cancer therapy.
The formulation of water insoluble organic compounds into nanoparticles has become a widely established method for enhancing the delivery and efficacy of cancer therapeutics. Therefore, a comparable approach when applied to water insoluble inorganic compounds should also promote similar advantages. Herein, we have successfully formulated insoluble iodinated cisplatin (CDDP-I) into an LPI NPs (lipid-coated iodinated CDDP nanoparticles). Two separate microemulsions were combined, each containing a precursor for the synthesis of CDDP-I. The resulting CDDP-I precipitate was then coated with an anionic lipid and dispersed in water with the help of an additional lipid. This method allows us to effectively encapsulate CDDP-I and was able to achieve a considerable drug loading of 82 wt%. Administered LPI NPs demonstrated high level accumulation in tumor tissues and exhibited an anti-cancer activity comparable to free CDDP in two melanoma xenograft models without inducing nephrotoxicity. The benefits offered through this delivery formulation are not unique to CDDP-I, as this versatile platform may be extended to the formulation of other inorganic compounds that are both water and oil insoluble into nanoparticles for superior anti-cancer efficacy.
['Guo|Shutao|S|', 'Wang|Yuhua|Y|', 'Miao|Lei|L|', 'Xu|Zhenghong|Z|', 'Lin|Ching-Hsuan M|CH|', 'Huang|Leaf|L|']
D000818:Animals D000970:Antineoplastic Agents D045744:Cell Line, Tumor D002945:Cisplatin D005260:Female D054879:Halogenation D006801:Humans D008055:Lipids D008081:Liposomes D008545:Melanoma D051379:Mice D008819:Mice, Nude D053758:Nanoparticles D012995:Solubility D014867:Water
Cisplatin Nanoparticle Inorganic drug Liposome