Rheumatic complications in cancer patients treated with immune checkpoint inhibitors.
Immune checkpoint inhibitors (ICIs) have revolutionized anticancer therapy due to their long-term clinical benefits and immune boosting mechanisms. However, despite their consistent therapeutic effects, the use of ICIs is associated with a spectrum of adverse events due to their autoimmune and auto-inflammatory actions. These adverse events can affect any organ system, including the endocrine, neurologic, gastrointestinal, cardiac, skin, pulmonary, and musculoskeletal systems. Of the immune-related adverse events (irAEs), rheumatic complications are common and appear to be distinct from irAEs in other organs in terms of variability of onset time, capacity for persistence, and relationship with pre-existing autoimmune rheumatologic diseases. In this article, we review the mechanisms of the anti-cancer effects of ICIs, the irAEs of immuno-oncology drugs, and the general recommendations for managing irAEs. In particular, we focus on rheumatologic irAEs and discuss their prevalence, clinical characteristics, and management.
['Lee|Kyung-Ann|KA|', 'Kim|Hae-Rim|HR|', 'Yoon|So Young|SY|']
D000074322:Antineoplastic Agents, Immunological D006801:Humans D009369:Neoplasms D015995:Prevalence D012216:Rheumatic Diseases D012307:Risk Factors D016896:Treatment Outcome D019139:Tumor Escape D059016:Tumor Microenvironment
Adverse effects Arthritis Immunotherapy Myositis Neoplasms