Utility of QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent TB in HIV-Positive Patients in a Medium-TB Burden Country.
BACKGROUND
The authors aimed to compare TST with QuantiFERON-TB Gold In-Tube (QFT) for detecting latent tuberculosis infection (LTBI) in HIV-infected patients in Iran as a TB-medium endemic country.


METHODS
In a cross-sectional design,130 HIV-positive patients in HIV clinic of Tehran University were studied. Patients screened for LTBI with QFT and TST simultaneously. Concordance between 2 tests results and variables associated with tests discordance were assessed.


RESULTS
Positive results found in 24.6% for TST and 7.7% for QFT. Overall agreement between them was 73.85% (Kappa = 0.083). History of imprisonment was associated with more positive TST (P = 0.014) and QFT (P = 0.01). Patients with intravenous drug use (IDU) history had significant discordant results (0.018).


CONCLUSION
The authors recommend QFT for all negative cases of TST in HIV-positive patients especially who had history of IDU.
['Khazraiyan|Hamideh|H|', 'Liaei|Zahra Abdi|ZA|', 'Koochak|Hamid Emadi|HE|', 'Ardalan|Farid Azmoudeh|FA|', 'Ahmadinejad|Zahra|Z|', 'Soltani|Ahmad|A|']
D000328:Adult D000368:Aged D003430:Cross-Sectional Studies D005260:Female D015658:HIV Infections D006801:Humans D007492:Iran D055985:Latent Tuberculosis D008297:Male D008875:Middle Aged D009161:Mycobacterium D014374:Tuberculin Test D055815:Young Adult
diagnosis latent tuberculosis tuberculosis HIV QuantiFERON