Prevalence of chronic kidney disease after preeclampsia.
BACKGROUND
Preeclampsia (PE), an endothelial disease that affects kidney function during pregnancy, is correlated to an increased future risk of cardiovascular and chronic kidney disease. The Kidney Disease Improving Global Outcomes (KDIGO) 2012 guideline emphasizes the combined role of glomerular filtration rate (GFR) and albuminuria in determining the frequency of monitoring of kidney function.


OBJECTIVES
In this study we evaluated the prevalence of CKD in women with a history of PE. We investigated how many seemingly healthy women required monitoring of kidney function according to the KDIGO guideline.


METHODS
We included 775 primiparous women with a history of PE. They were at least 4 months postpartum, and had no pre-existing hypertension, diabetes or kidney disease. We estimated GFR by the CKD-Epidemiology equation and urinary albumin loss by albumin creatinine ratio in a 24-h urine collection.


RESULTS
Most women, 669 (86.3 %), had a normal GFR and absent albuminuria. Based on the KDIGO guideline, 13.7 % would require at least yearly monitoring of kidney function. Only 1.4 % were classified to be at high risk for kidney function deterioration.


CONCLUSION
Monitoring of kidney function seems relevant for about one in seven women with a history of PE, mainly due to albuminuria. Albuminuria should be evaluated postpartum to identify those women that need further monitoring of kidney function.
['Lopes van Balen|Veronica Agatha|VA|http://orcid.org/0000-0002-8323-8596', 'Spaan|Julia Jeltje|JJ|', 'Cornelis|Tom|T|', 'Spaanderman|Marc Erich August|MEA|']
D000328:Adult D000419:Albuminuria D015415:Biomarkers D003404:Creatinine D005260:Female D005919:Glomerular Filtration Rate D006801:Humans D007668:Kidney D008954:Models, Biological D009426:Netherlands D011225:Pre-Eclampsia D011237:Predictive Value of Tests D011247:Pregnancy D015995:Prevalence D011379:Prognosis D051436:Renal Insufficiency, Chronic D018570:Risk Assessment D012307:Risk Factors D013997:Time Factors
Preeclampsia Kidney function Postpartum KDIGO criteria