Cardiolipin at the heart of stress response across kingdoms.
Cardiolipin is a key phospholipid most specifically found in the membrane of mitochondria in yeasts, plants, and animals. Cardiolipins are essential for the maintenance, the integrity, and the dynamics of mitochondria. In most eukaryotes mitochondria play a central role in the response and adaptation to stress conditions especially through their importance in the control of programmed cell death. To assess the impact of the absence of cardiolipin, knock-down of the expression of cardiolipin synthase, the last enzyme of cardiolipin synthesis pathway in eukaryotes has been performed in yeasts, animals, and plants. These studies showed that cardiolipin is not only important for mitochondrial ultrastructure and for the stability of respiratory complexes, but it is also a key player in the response to stress, the formation of reactive oxygen species, and the execution of programmed cell death.
['de Paepe|Rosine|R|', 'Lemaire|Stéphane D|SD|', 'Danon|Antoine|A|']
D000818:Animals D017209:Apoptosis D002308:Cardiolipins D045304:Cytochromes c D055785:Gene Knockdown Techniques D008565:Membrane Proteins D008928:Mitochondria D009154:Mutation D010944:Plants D017382:Reactive Oxygen Species D015398:Signal Transduction D013312:Stress, Physiological D017855:Transferases (Other Substituted Phosphate Groups) D015003:Yeasts
cardiolipin stress mitochondria programmed cell death reactive oxygen species