Towards precision medicine in severe asthma: Treatment algorithms based on treatable traits.
Asthma is a common disease, and although its clinical manifestations may be similar among patients, recent research discoveries have shown that it consists of several distinct clinical clusters or phenotypes, each with different underlying molecular pathways yielding different treatment responses. Based on these observations, an alternative approach - known as 'precision medicine' - has been proposed for the management of patients with severe asthma. Precision medicine advocates identification of treatable traits, linking them to therapeutic approaches targeting genetic, immunological, environmental, and/or lifestyle factors in individual patients. The main "goal" of this personalised approach is to enable choosing a treatment which will be more likely to produce a beneficial response in the individual patient rather than a 'one size fits all' approach. The aim of the present review is to discuss different ways of phenotyping asthma and to provide a rationale for treatment algorithms based on principles of precision medicine.
['Papaioannou|Andriana I|AI|', 'Diamant|Zuzana|Z|', 'Bakakos|Petros|P|', 'Loukides|Stelios|S|']
D000305:Adrenal Cortex Hormones D058666:Adrenergic beta-2 Receptor Agonists D000465:Algorithms D001249:Asthma D015415:Biomarkers D006801:Humans D020024:Leukotriene Antagonists D010641:Phenotype D057285:Precision Medicine D012720:Severity of Illness Index
Precision medicine Asthma Phenotype Biologics Biomarkers Endotype