Adjuvant chemotherapy for resected colorectal cancer metastases: Literature review and meta-analysis.
Surgical resection is the only option of cure for patients with metastatic colorectal cancer (CRC). However, the risk of recurrence within 18 mo after metastasectomy is around 75% and the liver is the most frequent site of relapse. The current international guidelines recommend an adjuvant therapy after surgical resection of CRC metastases despite the lower level of evidence (based on the quality of studies in this setting). However, there is still no standard treatment and the effective role of an adjuvant therapy remains controversial. The aim of this review is to report the state-of-art of systemic chemotherapy and regional chemotherapy with hepatic arterial infusion in the management of patients after resection of metastases from CRC, with a literature review and meta-analysis of the relevant randomized controlled trials.
['Brandi|Giovanni|G|', 'De Lorenzo|Stefania|S|', 'Nannini|Margherita|M|', 'Curti|Stefania|S|', 'Ottone|Marta|M|', "Dall'Olio|Filippo Gustavo|FG|", 'Barbera|Maria Aurelia|MA|', 'Pantaleo|Maria Abbondanza|MA|', 'Biasco|Guido|G|']
D000970:Antineoplastic Agents D017024:Chemotherapy, Adjuvant D015179:Colorectal Neoplasms D006498:Hepatectomy D006499:Hepatic Artery D006801:Humans D007261:Infusions, Intra-Arterial D008113:Liver Neoplasms D059146:Metastasectomy D012307:Risk Factors D016896:Treatment Outcome
Adjuvant chemotherapy Colorectal cancer Metastasectomy Adjuvant hepatic artery infusion Liver metastases