HapMap-based study: CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non-smokers.
BACKGROUND
The aim of this study was to evaluate the association between CYP2A13 polymorphisms and lung cancer susceptibility using the HapMap database.


METHODS
A case-control analysis of 532 subjects with lung cancer and 614 controls with no personal history of the disease was performed. The tag SNPs rs1645690 and rs8192789 for CYP2A13 were selected, and the genetic polymorphisms were confirmed experimentally through real-time PCR, cloning, and sequencing assay.


RESULTS
SNP frequency in this study was consistent with the HapMap Project database of Han-Chinese and lung cancer risk was associated with CYP2A13 polymorphisms in non-smokers. CYP2A13 shares a 93.5% identity with CYP2A6 in the amino acid sequence and the homologous sequences may interfere with the study of SNPs of CYP2A13.


CONCLUSIONS
CYP2A13 may be a potential key metabolic enzyme gene in the carcinogenesis of lung cancer in non-smokers. The common polymorphisms of CYP2A13 may be candidate biomarkers for lung cancer susceptibility in Han-Chinese.
['Hua|Feng|F|', 'Guo|Yonglu|Y|', 'Sun|Qiang|Q|', 'Yang|Leizhou|L|', 'Gao|Fang|F|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D044466:Asians D014408:Biomarkers, Tumor D016022:Case-Control Studies D002681:China D065637:Cytochrome P-450 CYP2A6 D005260:Female D056726:Genetic Association Studies D020022:Genetic Predisposition to Disease D060148:HapMap Project D006801:Humans D008175:Lung Neoplasms D008297:Male D008875:Middle Aged D000078405:Non-Smokers D020641:Polymorphism, Single Nucleotide
CYP2A13 lung cancer susceptibility genetic polymorphism HapMap Project