Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan.
BACKGROUND/AIM
Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among Taiwanese.


MATERIALS AND METHODS
One hundred and ninety-eight asthma patients and 453 non-asthmatic subjects were determined with respect to their MMP2 -1306 (rs243845) and -735 (rs2285053) genotypes.


RESULTS
CT and TT at MMP2 rs243845 are 17.7% and 1.5% among asthma cases, whereas their presence in healthy subjects is at 28.1% and 2.4%, respectively (p for trend=0.0118). In detail, the CT genotype in MMP2 rs243845 was associated with a decreased asthma risk [adjusted odds ratio (OR)=0.57, 95% confidence interval (CI)=0.37-0.78, p=0.0040], and the T allele conferred a significantly lower asthma risk compared to the wild-type C allele (adjusted OR=0.55, 95%CI=0.43-0.77, p=0.0042). No significance was found for MMP2 rs2285053.


CONCLUSION
The genotype of CT in MMP2 rs243845 may serve as a novel biomarker in determining susceptibility to asthma in Taiwan.
['Chen|Li-Hsiou|LH|', 'Chiu|Kuo-Liang|KL|', 'Hsia|Te-Chun|TC|', 'Lee|Yen-Hsien|YH|', 'Shen|Te-Chun|TC|', 'Li|Chia-Hsiang|CH|', 'Shen|Yi-Cheng|YC|', 'Chang|Wen-Shin|WS|', 'Tsai|Chia-Wen|CW|', 'Bau|DA-Tian|DT|']
D001249:Asthma D016022:Case-Control Studies D005787:Gene Frequency D020022:Genetic Predisposition to Disease D005838:Genotype D006801:Humans D020778:Matrix Metalloproteinase 2 D020641:Polymorphism, Single Nucleotide D011401:Promoter Regions, Genetic D013624:Taiwan
MMP2 promoter genotype Asthma Taiwan polymorphism