Mucosal CD30-Positive T-Cell Lymphoproliferative Disorder Arising in the Oral Cavity Following Dental Implants: Report of the First Case.
Mucosal CD30-positive T-cell lymphoproliferative disorder (CD30+ T-cell LPD) is a novel entity with unique clinicopathological features and an indolent behavior. Here we report the first case of mucosal CD30+ T-cell LPD arising in the oral cavity following dental implant. A 70-year-old woman presented with swelling and redness of the oral mucosa of right maxilla and left mandible surrounding dental implants that had been placed 8 years previously. Radiological examination revealed enhancing oral lesions and multiple cervical lymph nodes. Microscopic examination showed diffuse infiltration of large anaplastic cells with characteristic morphology of hallmark cells described in anaplastic large cell lymphoma. These cells were diffusely positive for CD30, CD3, CD4, CD2, CD5, CD7, TIA-1, and TCRβF1, but negative for CD20, CD8, CD45, EMA, ALK, and Epstein-Barr virus. T-cell monoclonality was detected in a TCRγ gene rearrangement study. This a unique case of mucosal CD30+ T-cell LPD with unusual presentation following dental implant.
['Yoon|Hye-Jung|HJ|', 'Choe|Ji-Young|JY|', 'Jeon|Yoon Kyung|YK|']
D000368:Aged D015921:Dental Implants D005260:Female D006801:Humans D007150:Immunohistochemistry D016130:Immunophenotyping D017730:Ki-1 Antigen D008232:Lymphoproliferative Disorders D009059:Mouth Diseases D013601:T-Lymphocytes
mucosal CD30-positive T-cell lymphoproliferative disorder dental implant anaplastic large cell lymphoma breast implant–associated lymphoma