A brief review: adipose-derived stem cells and their therapeutic potential in cardiovascular diseases.
Adipose-derived stem cells (ADSCs) are easily obtained and expanded, and have emerged as a novel source of adult stem cells for the treatment of cardiovascular diseases. These cells have been shown to have the capability of differentiating into cardiomyocytes, vascular smooth muscle cells, and endothelial cells. Furthermore, ADSCs secrete a series of paracrine factors to promote neovascularization, reduce apoptosis, and inhibit fibrosis, which contributes to cardiac regeneration. As a novel therapy in the regenerative field, ADSCs still face various limitations, such as low survival and engraftment. Thus, engineering and pharmacological studies have been conducted to solve these problems. Investigations have moved into phase I and II clinical trials examining the safety and efficacy of ADSCs in the setting of myocardial infarction. In this review, we discuss the differentiation and paracrine functions of ADSCs, the strategies promoting their therapeutic efficacy, and their clinical usage.
['Ma|Teng|T|', 'Sun|Jiacheng|J|', 'Zhao|Zhenao|Z|', 'Lei|Wei|W|', 'Chen|Yueqiu|Y|', 'Wang|Xu|X|', 'Yang|Junjie|J|', 'Shen|Zhenya|Z|']
D000273:Adipose Tissue D000818:Animals D017209:Apoptosis D002454:Cell Differentiation D060846:Cell Engineering D002986:Clinical Trials as Topic D006801:Humans D051379:Mice D009203:Myocardial Infarction D032383:Myocytes, Cardiac D018919:Neovascularization, Physiologic D019899:Paracrine Communication D051381:Rats D033581:Stem Cell Transplantation D013234:Stem Cells D066253:Vascular Remodeling
Adipose-derived stem cells Cardiovascular diseases Differentiation Paracrine effect Stem cell transplantation