(C6 F5 )3 B Catalyzed Chemoselective and ortho-Selective Substitution of Phenols with α-Aryl α-Diazoesters.
The development of an efficient method for the site-selective substitution of unprotected phenols has long been considered as an attractive but challenging task. Herein, we describe a highly chemo- and ortho-selective substitution reaction of phenols with α-aryl α-diazoacetates with commercially available (C6 F5 )3 B as the catalyst. This reaction proceeds under simple and mild conditions with high efficiency, it features a wide substrate scope and can be easily scaled up.
['Yu|Zhunzhun|Z|', 'Li|Yongfeng|Y|', 'Shi|Jiameng|J|', 'Ma|Ben|B|', 'Liu|Lu|L|', 'Zhang|Junliang|J|']
chemoselectivity phenols C−H functionalization boron catalysis diazo compounds