Major affective disorders in chronic obstructive pulmonary disease compared with other chronic respiratory diseases.
BACKGROUND
Chronic obstructive pulmonary disease (COPD) and other chronic respiratory diseases (CRDs) have significant impacts on quality of life including psychomotor domain.


PURPOSE
To evaluate three major affective disorders in subjects with COPD compared with other CRDs and nonill population.


MATERIALS AND METHODS
The Thai version of Mini International Neuropsychiatric Interview (MINI) was used as a diagnostic instrument for three major affective disorders (generalized anxiety disorder, major depressive disorder, and panic disorder) by face-to-face interview in assessing patients with CRDs [COPD, asthma, rhinasthma, all asthma (asthma and rhinasthma), and chronic rhinitis], and nonill subjects. Logistic regression analyses were used to determine the relation between major affective disorders and CRDs adjusting for age, sex, and disease severity.


RESULTS
Major affective disorders were more prevalent in CRDs than nonill groups (adjusted OR =2.6 [95% CI, 1.8-3.9], P<0.001). COPD patients had significantly more generalized anxiety and panic disorder (adjusted OR =4.0 [95% CI, 1.4-11.9], P=0.011, and 4.4 [95% CI, 1.1-18.1], P=0.038, respectively) but not major depressive disorder (adjusted OR =2.7 [95% CI, 0.8-9.0, P=0.105]) than nonill group. Comparing with all asthma, COPD patients had lower occurrence of major depressive and panic disorders (adjusted OR =0.1 [95% CI, 0.0-0.4], P=0.002, and 0.1 [95% CI, 0.0-0.9], P=0.043, respectively). There was no difference in major mood disorders in COPD, rhinasthma, and chronic rhinitis patients. Major affective disorders were not increased by disease severity in COPD.


CONCLUSION
Major affective disorders were significantly higher in CRDs than nonill population. Generalized anxiety and panic disorders were significantly high in COPD patients. Moreover, major depressive and panic disorders in COPD were significantly lower than all asthma. The prevalence of major affective disorders may not be related to severity of COPD.
['Pothirat|Chaicharn|C|', 'Chaiwong|Warawut|W|', 'Phetsuk|Nittaya|N|', 'Pisalthanapuna|Sangnual|S|', 'Chetsadaphan|Nonglak|N|', 'Inchai|Juthamas|J|']
D000328:Adult D000339:Affect D000368:Aged D001008:Anxiety Disorders D001249:Asthma D016022:Case-Control Studies D015897:Comorbidity D003430:Cross-Sectional Studies D003865:Depressive Disorder, Major D005260:Female D006306:Health Surveys D006801:Humans D007407:Interviews as Topic D016015:Logistic Models D008297:Male D008875:Middle Aged D016017:Odds Ratio D016584:Panic Disorder D015995:Prevalence D011569:Psychiatric Status Rating Scales D029424:Pulmonary Disease, Chronic Obstructive D012307:Risk Factors D012720:Severity of Illness Index D011795:Surveys and Questionnaires D013785:Thailand
asthma rhinitis mood disorders airway obstruction respiration disorders