Immunotoxic role of organophosphates: An unseen risk escalating SARS-CoV-2 pathogenicity.
Consistent gathering of immunotoxic substances on earth is a serious global issue affecting people under pathogenic stress. Organophosphates are among such hazardous compounds that are ubiquitous in nature. They fuel oxidative stress to impair antiviral immune response in living entities. Aside, organophosphates promote cytokine burst and pyroptosis in broncho-alveolar chambers leading to severe respiratory ailments. At present, we witness COVID-19 outbreak caused by SARS-CoV-2. Infection triggers cytokine storm coupled with inflammatory manifestations and pulmonary disorders in patients. Since organophosphate-exposure promotes necroinflammation and respiratory troubles hence during current pandemic situation, additional exposure to such chemicals can exacerbate inflammatory outcome and pulmonary maladies in patients, or pre-exposure to organophosphates might turn-out to be a risk factor for compromised immunity. Fortunately, antioxidants alleviate organophosphate-induced immunosuppression and hence under co-exposure circumstances, dietary intake of antioxidants would be beneficial to boost immunity against SARS-CoV-2 infection.
['Rajak|Prem|P|', 'Ganguly|Abhratanu|A|', 'Sarkar|Saurabh|S|', 'Mandi|Moutushi|M|', 'Dutta|Moumita|M|', 'Podder|Sayanti|S|', 'Khatun|Salma|S|', 'Roy|Sumedha|S|']
D000818:Animals D000975:Antioxidants D000086382:COVID-19 D000080424:Cytokine Release Syndrome D016207:Cytokines D004781:Environmental Exposure D006801:Humans D007109:Immunity D007249:Inflammation D010755:Organophosphates D018384:Oxidative Stress D058873:Pandemics D010575:Pesticides D000069292:Pyroptosis D012140:Respiratory Tract Diseases D000086402:SARS-CoV-2 D014774:Virulence
Organophosphate SARS-CoV-2 Oxidative stress COVID-19 Antioxidants