Manganese neurotoxicity and the role of reactive oxygen species.
Manganese (Mn) is an essential dietary nutrient, but an excess or accumulation can be toxic. Disease states, such as manganism, are associated with overexposure or accumulation of Mn and are due to the production of reactive oxygen species, free radicals, and toxic metabolites; alteration of mitochondrial function and ATP production; and depletion of cellular antioxidant defense mechanisms. This review focuses on all of the preceding mechanisms and the scientific studies that support them as well as providing an overview of the absorption, distribution, and excretion of Mn and the stability and transport of Mn compounds in the body.
['Martinez-Finley|Ebany J|EJ|', 'Gavin|Claire E|CE|', 'Aschner|Michael|M|', 'Gunter|Thomas E|TE|']
D000255:Adenosine Triphosphate D000975:Antioxidants D005609:Free Radicals D006801:Humans D008345:Manganese D020149:Manganese Poisoning D008928:Mitochondria D009474:Neurons D018384:Oxidative Stress D017382:Reactive Oxygen Species
Manganese Reactive oxygen species Manganism Free radicals DA autoxidation Mitochondrial dysfunction