Immunohistochemical differentiation between spindle cell lipoma and neurofibroma of oral cavity using CD34 and SOX10.
Spindle cell lipoma (SCL), also called as pleomorphic adenoma, is a rare variant of lipoma histopathologically characterized by an admixture of mature fat cells with spindle cells and occasionally mast cells with myxoid connective tissue stroma and thick bends of birefringent collagen. Although buccal mucosa is the most common location for oral lipomas, for SCL, it is an exceedingly rare location. We report a case of an asymptomatic swelling of buccal mucosa that simulated the features of neurofibroma on histopathological examination, and the final diagnosis of SCL was made on the basis of immunohistochemical features. This is the first documentation of oral SCL using SOX10 to achieve the final diagnosis.
['Bajpai|Manas|M|', 'Pardhe|Nilesh|N|', 'Kumar|Manish|M|']
D000328:Adult D018952:Antigens, CD34 D003937:Diagnosis, Differential D006801:Humans D007150:Immunohistochemistry D008067:Lipoma D008297:Male D009062:Mouth Neoplasms D009455:Neurofibroma D055757:SOXE Transcription Factors
spindle cell lipoma neurofibroma CD34 SOX10 connective tissue tumor soft-tissue tumor