Nickel carcinogenesis mechanism: cell cycle dysregulation.
Nickel (Ni) is a widely distributed metal in the environment and an important pollutant due to its widespread industrial applications. Ni has various toxicity in humans and experimental animals, including carcinogenicity. However, the carcinogenic effects of Ni remain troublesome. Cell cycle dysregulation may be an important carcinogenic mechanism and is also a potential molecular mechanism for Ni complexes anti-cancerous effects. Therefore, we conducted a literature review to summarize the effects of Ni on cell cycle. Up to now, there were three different reports on Ni-induced cell cycle arrest: (i) Ni can induce cell cycle arrest in G0/G1 phase, phosphorylation and degradation of IkappaB kinase-alpha (IKKα)-dependent cyclin D1 and phosphoinositide-3-kinase (PI3K)/serine-threonine kinase (Akt) pathway-mediated down-regulation of expressions of cyclin-dependent kinases 4 (CDK4) play important role in it; (ii) Ni can induce cell cycle arrest in S phase, but the molecular mechanism is not known; (iii) G2/M phase is the target of Ni toxicity, and Ni compounds cause G2/M cell cycle phase arrest by reducing cyclinB1/Cdc2 interaction through the activation of the ataxia telangiectasia mutated (ATM)-p53-p21 and ATM-checkpoint kinase inhibitor 1 (Chk1)/Chk2-cell division cycle 25 (Cdc25) pathways. Revealing the mechanisms of cell cycle dysregulation associated with Ni exposure may help in the prevention and treatment of Ni-related carcinogenicity and toxicology.
['Guo|Hongrui|H|', 'Deng|Huidan|H|', 'Liu|Huan|H|', 'Jian|Zhijie|Z|', 'Cui|Hengmin|H|', 'Fang|Jing|J|', 'Zuo|Zhicai|Z|', 'Deng|Junliang|J|', 'Li|Yinglun|Y|', 'Wang|Xun|X|', 'Zhao|Ling|L|']
D000818:Animals D064007:Ataxia Telangiectasia Mutated Proteins D063646:Carcinogenesis D002453:Cell Cycle D018797:Cell Cycle Proteins D002455:Cell Division D006801:Humans D009532:Nickel D015398:Signal Transduction D016159:Tumor Suppressor Protein p53
Nickel Cell cycle Carcinogenic mechanism G2/M