Number of colony-forming unit-Hill colonies among children and teenagers with obesity, dyslipidemia and breastfeeding history.
BACKGROUND AND AIMS
The number of colony-forming unit (CFU)-Hill colonies has been proposed as a biomarker of vascular function and cardiovascular risk in adults but information about its role in children is scarce. This study evaluates the associations between obesity, cardiovascular risk factors and breastfeeding history with the numbers of CFU-Hill colonies in a sample of young people.


METHODS AND RESULTS
We selected 49 children and teenagers between ages 10 and 17 (65.3% boys) from Mexican Health Care system. Physical activity and Anthropometric measures data were registered. CFU-Hill colonies were cultured from mononuclear cells obtained from venous blood. We detected inverse associations between the formation of CFU-Hill colonies and body mass index (BMI; β = -1.53; 95% confidence interval [CI], -1.92, -1.13), triglycerides (β = -0.26; 95%CI = -0.34, -0.18), total cholesterol (β = -0.13; 95%CI = -0.17, -0.08), Low Density Lipoprotein (LDL) (β = -0.20; 95%CI = -0.31, -0.09) and glucose (β = -0.37; 95%CI = -0.55, -0.18) using multivariate models. Breastfeeding duration showed a 1.46-colony increase for each month of breastfeeding (95%CI = 0.73, 2.18).


CONCLUSIONS
CFU-Hill colony-forming capacity in children and teenagers was inversely associated with obesity, dyslipidemia and high blood levels of glucose. In contrast a longer breastfeeding duration was directly associated with an increased number of CFU-Hill colonies. However these results must be confirmed with further studies. Our findings support the importance of promoting breastfeeding and monitoring nutritional and metabolic status at an early age to prevent chronic disease development.
['Salazar-Martinez|E|E|', 'Rodriguez-Valentin|R|R|', 'Albavera-Hernandez|C|C|', 'Carreon-Rodriguez|A|A|', 'Lazcano-Ponce|E|E|']
D000293:Adolescent D000367:Age Factors D015415:Biomarkers D001786:Blood Glucose D001942:Breast Feeding D002478:Cells, Cultured D002648:Child D002664:Child Nutritional Physiological Phenomena D003114:Colony-Forming Units Assay D003430:Cross-Sectional Studies D050171:Dyslipidemias D066026:Endothelial Progenitor Cells D005260:Female D000070497:Healthy Lifestyle D006801:Humans D008055:Lipids D008297:Male D008800:Mexico D009752:Nutritional Status D063766:Pediatric Obesity D010641:Phenotype
Obesity Dyslipidemia Breastfeeding Colony forming unit-Hill