Specific frequency band of amplitude low-frequency ﬂuctuation predicts Parkinson's disease.
Resting-state functional magnetic resonance imaging (RS-fMRI) has been considered for development as a biomarker and analytical tool for evaluation of Parkinson's disease (PD). Here we utilized analysis of the amplitude low-frequency ﬂuctuations (ALFF) to determine changes in intrinsic neural oscillations in 72 patients with PD. Two different frequency bands (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz) were analyzed. In the slow-5 band, PD patients compared with controls had increased ALFF values mainly in the caudate and several temporal regions, as well as decreased ALFF values in the cerebellum and the parieto-temporo-occipital cortex. Additionally, in the slow-4 band, PD patients relative to controls exhibited reduced ALFF value in the thalamus, cerebellum, and several occipital regions. Together, our data demonstrate that PD patients have widespread abnormal intrinsic neural oscillations in the corticostriatal network in line with the pathophysiology of PD, and further suggest that the abnormalities are dependent on speciﬁc frequency bands. Thus, frequency domain analyses of resting state BOLD signals may provide a useful means to study the pathophysiology of PD and the physiology of the brain's dopaminergic pathways.
['Zhang|Jiuquan|J|', 'Wei|Luqing|L|', 'Hu|Xiaofei|X|', 'Zhang|Yanling|Y|', 'Zhou|Daiquan|D|', 'Li|Chuan|C|', 'Wang|Xin|X|', 'Feng|Hua|H|', 'Yin|Xuntao|X|', 'Xie|Bin|B|', 'Wang|Jian|J|']
D000368:Aged D001921:Brain D001931:Brain Mapping D005260:Female D007839:Functional Laterality D019416:Head Movements D006801:Humans D007091:Image Processing, Computer-Assisted D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D010100:Oxygen D010300:Parkinson Disease D011237:Predictive Value of Tests
Amplitude low-frequency ﬂuctuation Parkinson's disease Resting-state functional magnetic resonance imaging Corticostriatal network