Increased food allergy and vitamin D: randomized, double-blind, placebo-controlled trial.
BACKGROUND
To elucidate whether maternal vitamin D supplementation during lactation improves infantile eczema and other subsequent allergic disorders, a randomized, double-blind, placebo-controlled trial was performed.


METHODS
Mothers (n = 164) of infants with facial eczema at 1 month check-up were randomly assigned to receive vitamin D3 supplements (n = 82; 800 IU/day) or placebo (n = 82) for 6 weeks from May 2009 to January 2011. The primary outcome was infantile eczema quantified on Scoring Atopic Dermatitis (SCORAD) index at 3 month check-up, and the secondary outcomes were atopic dermatitis, food allergy, and wheeze diagnosed by doctors up to 2 years of age.


RESULTS
There was no significant difference in SCORAD at 3 month check-up between the two groups. Doctor-diagnosed food allergy was significantly more common up to age 2 years in the vitamin D group (10/39, 25.7%) than in the placebo group (3/40, 7.5%; risk ratio (RR), 3.42; 95% confidence interval [CI]: 1.02-11.77; P = 0.030). Moreover, at least one secondary outcome was also significantly more common in the vitamin D group (17/39, 43.6%) than in the placebo group (7/40, 17.5%; RR, 2.49; 95%CI: 1.16-5.34; P = 0.012).


CONCLUSIONS
Vitamin D supplementation may not decrease the severity of infantile eczema at 3 months of age, but may rather increase the risk of later food allergy up to 2 years of age. Because a large number of subjects was lost to follow up, further study is needed to confirm the findings.
['Norizoe|Chihiro|C|', 'Akiyama|Naoe|N|', 'Segawa|Takaaki|T|', 'Tachimoto|Hiroshi|H|', 'Mezawa|Hidetoshi|H|', 'Ida|Hiroyuki|H|', 'Urashima|Mitsuyoshi|M|']
D000284:Administration, Oral D000328:Adult D001942:Breast Feeding D019587:Dietary Supplements D004305:Dose-Response Relationship, Drug D004311:Double-Blind Method D005260:Female D005500:Follow-Up Studies D005512:Food Hypersensitivity D006801:Humans D015994:Incidence D007223:Infant D007231:Infant, Newborn D007564:Japan D008297:Male D012189:Retrospective Studies D014807:Vitamin D D014815:Vitamins
food allergy vitamin D infantile eczema prevention randomized controlled trial