New streptophenazines from marine Streptomyces sp. 182SMLY.
Six phenazines including three new ones were isolated from the culture of a marine actinomycete Streptomyces sp. 182SMLY. Based on the analyses of NMR, HRESIMS, optical rotation value, and CD data, the structures of these isolated compounds were determined as new phenazines of (-)-streptophenazines M-O and known phenazines of 1-carbomethoxyphenazine and (-)-streptophenazines A and B. (-)-Streptophenazine B showed activity in suppressing the growth of methicillin-resistant Staphylococcus aureus with MIC value of 4.2 μg/mL.
['Liang|Ying|Y|', 'Chen|Lu|L|', 'Ye|Xuewei|X|', 'Anjum|Komal|K|', 'Lian|Xiao-Yuan|XY|', 'Zhang|Zhizhen|Z|']
D000900:Anti-Bacterial Agents D009682:Magnetic Resonance Spectroscopy D055624:Methicillin-Resistant Staphylococcus aureus D008826:Microbial Sensitivity Tests D010619:Phenazines D013302:Streptomyces D014871:Water Microbiology
Streptomyces sp. 182SMLY (-)-streptophenazine B (-)-streptophenazines M–O antibacterial activity