Fabrication, multi-scale characterization and in-vitro evaluation of porous hybrid bioactive glass polymer-coated scaffolds for bone tissue engineering.
Bioactive glass-based scaffolds are commonly used in bone tissue engineering due to their biocompatibility, mechanical strength and adequate porous structure. However, their hydrophobicity and brittleness limits their practical application. In this study, to improve nanomechanical properties of such scaffolds, pure bioactive hybrid glass and two bioactive hybrid glass-polymer coated composites were fabricated. A complementary micro and nanoscale characterization techniques (SEM, AFM, μCT, FTIR, compressive test, goniometer) were implemented for detailed description of architecture and physicochemical properties of hybrid bioactive glass-based scaffolds with emphasis on nano-mechanics. The final step was in-vitro evaluation of three dimensional macroporous structures. Our findings show that after polymer addition, architecture, topography and surface properties of the scaffolds were changed and promoted favoured behaviour of the cells.
['Chlanda|Adrian|A|', 'Oberbek|Przemysław|P|', 'Heljak|Marcin|M|', 'Kijeńska-Gawrońska|Ewa|E|', 'Bolek|Tomasz|T|', 'Gloc|Michał|M|', 'John|Łukasz|Ł|', 'Janeta|Mateusz|M|', 'Woźniak|Michał J|MJ|']
D001842:Bone and Bones D045744:Cell Line, Tumor D002470:Cell Survival D002516:Ceramics D020099:Coated Materials, Biocompatible D055119:Elastic Modulus D006801:Humans D053758:Nanoparticles D011108:Polymers D016062:Porosity D017550:Spectroscopy, Fourier Transform Infrared D013314:Stress, Mechanical D023822:Tissue Engineering D054457:Tissue Scaffolds D055114:X-Ray Microtomography
Bioactive glass Scaffold Tissue engineering Mechanical properties