Association of Metabolic Syndrome and Its Components with Decreased Estimated Glomerular Filtration Rate in Adults.
BACKGROUND/AIMS
Metabolic syndrome (MetS) and its metabolic components, the common risk factors, may be involved in the development and progression of decreased estimated glomerular filtration rate (eGFR). The aim of this study was to examine the association of MetS and its metabolic components with eGFR status and severity among Chinese adults.


METHODS
The population-based, cross-sectional study recruited a total of 33,300 Chinese adults (aged ≥18 years) from 4 study community sites in Songjiang District, Shanghai, between June 2016 and December 2017. Decreased eGFR was defined as a value of eGFR below 60 mL/min/1.73 m2. Weighted multiple logistic regression models were used to examine the association of MetS and its components with eGFR status and severity.


RESULTS
After adjusting for potential confounders, subjects with MetS had an increased risk of decreased eGFR with an adjusted OR of 1.76 (95% CI 1.53-2.01), and subjects with increasing numbers of MetS components had a gradually increased risk for decreased eGFR (p trend <0.001). The multivariable-adjusted ORs (95% CI) of decreased eGFR were 1.66 (1.44-1.93) for abdominal obesity, 1.37 (1.18-1.60) for elevated triglycerides, 1.13 (0.96-1.33) for reduced high-density lipoprotein cholesterol, 0.84 (0.72-0.98) for elevated fasting glucose, and 1.92 (1.57-2.35) for elevated blood pressure (BP). Furthermore, these associations remained in most of the subgroups analyses. Significant associations between elevated BP and the risks of mildly, moderately, and severely decreased eGFR were also found.


CONCLUSIONS
MetS was independently associated with an increased risk of decreased eGFR, and individual components of MetS each play a different role in decreased eGFR. Elevated BP may be an important risk factor for the progression of renal dysfunction or even chronic kidney disease.
['Qiu|Yun|Y|', 'Zhao|Qi|Q|', 'Gu|Yian|Y|', 'Wang|Na|N|', 'Yu|Yuting|Y|', 'Wang|Ruiping|R|', 'Zhang|Yue|Y|', 'Zhu|Meiying|M|', 'Liu|Xing|X|', 'Jiang|Yonggen|Y|', 'Zhao|Genming|G|']
D000328:Adult D000368:Aged D044466:Asians D001786:Blood Glucose D002681:China D008076:Cholesterol, HDL D003430:Cross-Sectional Studies D057286:Electronic Health Records D005260:Female D005919:Glomerular Filtration Rate D006801:Humans D006973:Hypertension D016015:Logistic Models D008297:Male D024821:Metabolic Syndrome D008875:Middle Aged D056128:Obesity, Abdominal D012307:Risk Factors D014280:Triglycerides
Metabolic syndrome Estimated glomerular filtration rate Chronic kidney disease Renal function decline