Two new C21 steroidal glycosides isolated from Cynanchum komarovii.
The present study was designed to further investigate the C21 steroidal glycosides in Cynanchum plants. Two new steroidal glycosides based on a 13, 14:14, 15-disecopregnane-type aglycone, komaroside P (1) and komaroside Q (2), together with three known compounds (3-5) were isolated from the whole herbs of Cynanchum komarovii. The aglycones of compounds 1 and 2 were two new disecopregnane. Their structures were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. All the compounds (1-5) showed potent inhibitory activities against human leukemia cell lines (HL-60) with IC50 values ranging from 16.6 to 26.3 μmol·L-1, compared to the positive control 5-fluorouracil (6.4 μmol·L-1).
['Zhao|Dan|D|', 'Su|Shan-Shan|SS|', 'Chen|Shao-Fei|SF|', 'Lu|Xiao-Jie|XJ|', 'Chen|Gang|G|', 'Wang|Yu-Bo|YB|', 'Su|Guang-Yue|GY|', 'Pei|Yue-Hu|YH|']
D002470:Cell Survival D031105:Cynanchum D004365:Drugs, Chinese Herbal D006027:Glycosides D018922:HL-60 Cells D006801:Humans D009682:Magnetic Resonance Spectroscopy D015394:Molecular Structure D013256:Steroids
Cynanchum komarovii C(21) steroidal glycosides Cytotoxic activity