CD30 expression and prognostic significance in R-EPOCH-treated patients with diffuse large B-cell lymphoma.
A few recent studies investigated the prognostic impact of CD30 expression in diffuse large B-cell lymphoma (DLBCL) patients treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. No study has evaluated the significance of CD30 expression in DLBCL patients treated with rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (R-EPOCH). In a group of 97 patients with DLBCL and high-risk features who received R-EPOCH induction therapy, we studied CD30 expression by immunohistochemistry using different cutoff values (>0% and ≥20% of lymphoma cells, respectively) and correlated with prognosis. CD30 expression was detected in 24 (25%) cases using a cutoff greater than 0% and in 12 (12%) cases using a cutoff of 20% or greater. The clinicopathological features were similar between CD30+ and CD30-negative groups. A major difference was that MYC rearrangement was infrequent in the CD30+ group: 2 (9%) of 23 in CD30+ versus 25 (35%) of 72 in CD30-negative group (P=.02). CD30 expression was not associated with germinal center B-cell-like (GCB) or non-GCB type. Overall survival (OS) was not significantly different between patients with CD30+ and patients with CD30-negative DLBCL, either for all patients or for the subset of patients without MYC rearrangement, regardless of cutoff (P>.05). CD30 expression was not associated with OS in either GCB or non-GCB subtype (P>.05, > 0% cutoff). In conclusion, CD30 expression was detected in up to 25% of cases of DLBCL and was more frequent in tumors without MYC rearrangement. CD30 expression was not associated with OS in R-EPOCH-treated de novo DLBCL patients.
['Xu|Jie|J|', 'Oki|Yasuhiro|Y|', 'Saksena|Annapurna|A|', 'Desai|Parth|P|', 'Lin|Pei|P|', 'Tang|Guilin|G|', 'Yin|C Cameron|CC|', 'You|M James|MJ|', 'Thakral|Beenu|B|', 'Medeiros|L Jeffrey|LJ|', 'Li|Shaoying|S|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D000971:Antineoplastic Combined Chemotherapy Protocols D014408:Biomarkers, Tumor D003520:Cyclophosphamide D004317:Doxorubicin D005047:Etoposide D005260:Female D015321:Gene Rearrangement D006801:Humans D007150:Immunohistochemistry D053208:Kaplan-Meier Estimate D017730:Ki-1 Antigen D016403:Lymphoma, Large B-Cell, Diffuse D008297:Male D008875:Middle Aged D011237:Predictive Value of Tests D011241:Prednisone D016271:Proto-Oncogene Proteins c-myc D015203:Reproducibility of Results D000069283:Rituximab D013997:Time Factors D016896:Treatment Outcome D014750:Vincristine D055815:Young Adult
CD30 DLBCL R-EPOCH Prognosis MYC rearrangement