Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis.
The involvement of serotonin in responses to negative feedback is well established. Acute serotonin reuptake inhibition has enhanced sensitivity to negative feedback (SNF), modelled by behaviour in probabilistic reversal learning (PRL) paradigms. Whilst experiments employing acute tryptophan depletion (ATD) in humans, to reduce serotonin synthesis, have shown no clear effect on SNF, sample sizes have been small. We studied a large sample of healthy volunteers, male and female, and found ATD had no effect on core behavioural measures in PRL. These results indicate that ATD effects can differ from other manipulations of serotonin expected to have a parallel or opposing action.
['Kanen|Jonathan W|JW|0000-0002-4095-5405', 'Arntz|Frederique E|FE|', 'Yellowlees|Robyn|R|', 'Cardinal|Rudolf N|RN|', 'Price|Annabel|A|', 'Christmas|David M|DM|', 'Sahakian|Barbara J|BJ|', 'Apergis-Schoute|Annemieke M|AM|', 'Robbins|Trevor W|TW|']
D005246:Feedback D005260:Female D006801:Humans D008297:Male D012193:Reversal Learning D018401:Sample Size D012701:Serotonin D014364:Tryptophan
probabilistic reversal learning tryptophan depletion Serotonin