The blood mSEPT9 is capable of assessing the surgical therapeutic effect and the prognosis of colorectal cancer.
AIM
To investigate the performance of methylated SEPT9 (mSEPT9) in assessing the surgical therapeutic effect and prognosis of colorectal cancer (CRC).


METHODS
Blood samples before surgery and 1 and 7 days after surgery were obtained from 120 CRC patients, and mSEPT9 and carcinoembryonic antigen (CEA) assays were performed.


RESULTS
The mean plasma mSEPT9 level showed 57.6-times and 131.1-times decrease 1 day and 7 days after surgery, respectively. In contrast, mean CEA levels showed 2.51-and 2.70-times decrease 1 and 7 days after surgery. 86.7% of patients can be assessed by mSEPT9 while 44.2% can be assessed by CEA. Positive mSEPT9 detection before surgery correlated with higher risk of death after surgery.


CONCLUSION
mSEPT9 is effective for CRC postsurgical assessment and prognosis prediction.
['Song|Lele|L|', 'Guo|Shaohua|S|', 'Wang|Jiayu|J|', 'Peng|Xiumei|X|', 'Jia|Jia|J|', 'Gong|Yuan|Y|', 'Yang|Bo|B|', 'Xiao|Wenhua|W|', 'Dong|Cheng|C|', 'Liu|Hongyi|H|', 'Li|Yuemin|Y|']
D000368:Aged D002272:Carcinoembryonic Antigen D015179:Colorectal Neoplasms D005260:Female D006801:Humans D008297:Male D008745:Methylation D008875:Middle Aged D009363:Neoplasm Proteins D011379:Prognosis D058112:Septins
prognosis colorectal cancer methylation SEPT9 surgery CEA ctDNA qPCR septin 9