Microfluidic chip-based liquid chromatography coupled to mass spectrometry for determination of small molecules in bioanalytical applications: an update.
Many microfluidic chip-based LC-MS systems have been utilized for high-throughput analysis in various fields of bioanalytical applications such as proteomic, glycomic, pharmaceutical, and clinical research. This review is an update of a previous review article (Electrophoresis 2012, 33, 635-643) to mainly cover the most recent advancements in chip-based LC-MS for determining small molecules in bioanalysis. First, the different types of microfluidic chip devices for chip-based LC-MS analysis will be discussed. Following the discussion of the recent developments in the chip-based instrumentation, the applications of chip-based LC-MS for determining small molecules, such as glycans, pharmaceutical drugs, drugs of abuse, drug metabolites, and biomarkers in various biological sample matrixes will also be included in this review.
['Lin|Shu-Ling|SL|', 'Lin|Tzuen-Yeuan|TY|', 'Fuh|Ming-Ren|MR|']
D015415:Biomarkers D045744:Cell Line, Tumor D002853:Chromatography, Liquid D006801:Humans D013058:Mass Spectrometry D046210:Microfluidic Analytical Techniques D004364:Pharmaceutical Preparations D011134:Polysaccharides
Bioanalytical applications Chip-based LC-MS MS/MS