Usefulness of the neutrophil-to-lymphocyte ratio to prediction of type 2 diabetes mellitus in morbid obesity.
BACKGROUND
There is growing consensus in the literature that inflammation plays a central role in the pathophysiology of obesity and type 2 diabetes mellitus (T2DM) and cardiovascular complications. Neutrophil-to-lymphocyte ratio (NLR) provides a simple method for assessment of inflammatory status and it is a new, inexpensive marker. The aim of the present study was to investigate the predictive value of preprocedural (before the OGTT) NLR on development of type 2 diabetes (T2DM) in morbid obesity patients (MOP).


METHODS
306 MOP (body mass index ≥ 40 kg/m(2)) and 95 normal weight patients with normal OGTT [fasting plasma glucose (FPG)<100mg/dL. Two-hour glucose during OGTT<140 mg/dL] were evaluated in this study.


RESULTS
The mean ± SD NLR of MOP was significantly higher than that of patients with normal weight healthy patients (3.67 ± 0.95 vs. 1.82 ± 1.02, P<0.001, respectively). In receiver operating characteristics curve analysis, NLR>3.12 had 79.2% sensitivity and 64.9% specificity in predicting T2DM. Logistic regression analysis showed that elevated NLR (OR: 2.577, 95% CI: 1.363-4.872, P=0.004) was an independent variable for predicting T2DM in MOP.


CONCLUSIONS
MOP have higher NLR than healthy controls. High NLR is a powerful and independent predictor of T2DM in MOP. Elevated NLR levels are usually considered as an inflammatory marker. The results of this study suggested that inflammation plays a role in the pathogenesis of T2DM with MOP.
['Yilmaz|H|H|', 'Ucan|B|B|', 'Sayki|M|M|', 'Unsal|I|I|', 'Sahin|M|M|', 'Ozbek|M|M|', 'Delibasi|T|T|']
D000328:Adult D015415:Biomarkers D016022:Case-Control Studies D003924:Diabetes Mellitus, Type 2 D005260:Female D005500:Follow-Up Studies D006801:Humans D008214:Lymphocytes D008297:Male D008875:Middle Aged D009504:Neutrophils D009767:Obesity, Morbid D011379:Prognosis D012372:ROC Curve D012189:Retrospective Studies D012307:Risk Factors
Neutrophil-to-lymphocyte ratio Type 2 diabetes mellitus Morbid obesity Inflammation marker