Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response.
mRNA vaccine platforms present numerous advantages, such as versatility, rapid production, and induction of cellular and humoral responses. Moreover, mRNAs have inherent adjuvant properties due to their complex interaction with pattern recognition receptors (PRRs). This recognition can be either beneficial in activating antigen-presenting cells (APCs) or detrimental by indirectly blocking mRNA translation. To decipher this Janus effect, we describe the different innate response mechanisms triggered by mRNA molecules and how each element from the 5' cap to the poly-A tail interferes with innate/adaptive immune responses. Then, we emphasize the importance of some critical steps such as production, purification, and formulation as key events to further improve the quality of immune responses and balance innate and adaptive immunity.
['Linares-Fernández|Sergio|S|', 'Lacroix|Céline|C|', 'Exposito|Jean-Yves|JY|', 'Verrier|Bernard|B|']
D056704:Adaptive Immunity D000818:Animals D006801:Humans D007113:Immunity, Innate D012333:RNA, Messenger D051192:Receptors, Pattern Recognition D014614:Vaccines, Synthetic
mRNA vaccines adaptive immunity innate immunity mRNA design