Successful thrombolytic treatment of neonatal arterial thromboses.
Compared to children of other age groups neonates show an increased thrombotic risk. The acute therapy depends on thrombus age, the localisation of vascular occlusion and the severity of the underlying disease. The treatment of choice is represented by the administration of unfractionated (UFH) or low molecular weight heparin (LMWH). If loss of limbs or organs is imminent, the application of thrombolytic treatment with recombinant tissue-type plasminogen activator (rt-PA) should be considered whilst taking into account the associated bleeding risk. We report on two patients in which thrombolytic therapy has been conducted successfully.
['Stächele|J|J|', 'Dinger|J|J|', 'Brenner|S|S|', 'Hofmann|S R|SR|', 'Ifflaender|S|S|', 'Knöfler|R|R|']
D000925:Anticoagulants D004359:Drug Therapy, Combination D005260:Female D006493:Heparin D006801:Humans D007231:Infant, Newborn D007232:Infant, Newborn, Diseases D007234:Infant, Premature D008297:Male D015912:Thrombolytic Therapy D013927:Thrombosis D010959:Tissue Plasminogen Activator D016896:Treatment Outcome
Neonates thrombolytic therapy thrombosis