Does ovarian reserve predict egg quality in unstimulated therapeutic donor insemination cycles?
OBJECTIVE
To compare reproductive outcomes of patients with very low, low, normal, and high antral follicle counts undergoing unstimulated therapeutic donor insemination (TDI) cycles.


DESIGN
Retrospective cohort study.


SETTING
University-affiliated regional fertility clinic.


PATIENT(S)
Four hundred fifty-nine patients who had 1,107 TDI treatment cycles from January 2006 to December 2013.


INTERVENTION(S)
Unstimulated therapeutic donor insemination.


MAIN OUTCOME MEASURE(S)
Clinical pregnancy rates and miscarriage rates as surrogate markers for oocyte quality.


RESULT(S)
The overall pregnancy rate per cycle start was 12.46% in the study population. There was no difference in per-cycle or cumulative pregnancy rates among patients with very low, low, average, or high antral follicle counts within each patient age group of ≤35, 36-39, and ≥40 years. The overall miscarriage rate per pregnancy was 13.61%. When stratified by patient age, there was no correlation between miscarriage rate and antral follicle count.


CONCLUSION(S)
AFC is not a predictor of pregnancy or miscarriage rates in patients undergoing unstimulated TDI.
['Ripley|Mike|M|', 'Lanes|Andrea|A|', 'Léveillé|Marie-Claude|MC|', 'Shmorgun|Doron|D|']
D000022:Abortion, Spontaneous D000328:Adult D053713:Azoospermia D005260:Female D006801:Humans D007316:Insemination, Artificial, Heterologous D008297:Male D008423:Maternal Age D009864:Ontario D006080:Ovarian Follicle D010050:Ovarian Function Tests D065851:Ovarian Reserve D011237:Predictive Value of Tests D011247:Pregnancy D018873:Pregnancy Rate D012189:Retrospective Studies D012307:Risk Factors D016896:Treatment Outcome D014463:Ultrasonography
therapeutic donor insemination antral follicle count pregnancy rate miscarriage rate Diminished ovarian reserve