Landscape of Noncoding RNA in Prostate Cancer.
The transcriptome of prostate cancer is highly heterogeneous, with noncoding transcripts being essential players. Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are two unique classes of noncoding RNA drawing increasing attention. Biologically, they have intriguing properties with important regulatory functions. Clinically, they present as promising biomarkers and therapeutic targets. Recent advancements in technologies have opened up new directions for noncoding RNA research, which include RNA-protein interaction, RNA secondary structure, and spatial transcriptomics. Furthermore, recent work has also evaluated the clinical applications of these noncoding RNAs in noninvasive liquid biopsy and RNA-based therapies. In this review, we summarize recent findings on lncRNAs and circRNAs in prostate cancer, discuss their clinical utilities, and highlight these exciting areas of research.
['Hua|Junjie T|JT|', 'Chen|Sujun|S|', 'He|Housheng H|HH|']
D014408:Biomarkers, Tumor D015972:Gene Expression Regulation, Neoplastic D020022:Genetic Predisposition to Disease D006801:Humans D008297:Male D011471:Prostatic Neoplasms D000079962:RNA, Circular D062085:RNA, Long Noncoding D016601:RNA-Binding Proteins D013329:Structure-Activity Relationship
noncoding RNA prostate cancer long noncoding RNA circular RNA biomarkers therapeutics