Direct correlation of electrochemical behaviors with anti-thrombogenicity of semiconducting titanium oxide films.
Biomaterials-associated thrombosis is dependent critically upon electrochemical response of fibrinogen on material surface. The relationship between the response and anti-thrombogenicity of biomaterials is not well-established. Titanium oxide appears to have good anti-thrombogenicity and little is known about its underlying essential chemistry. We correlate their anti-thrombogenicity directly to electrochemical behaviors in fibrinogen containing buffer solution. High degree of inherent n-type doping was noted to contribute the impedance preventing charge transfer from fibrinogen into film (namely its activation) and consequently reduced degree of anti-thrombogenicity. The impedance was the result of high donor carrier density as well as negative flat band potential.
['Wan|Guojiang|G|', 'Lv|Bo|B|', 'Jin|Guoshou|G|', 'Maitz|Manfred F|MF|', 'Zhou|Jianzhang|J|', 'Huang|Nan|N|']
D001792:Blood Platelets D002448:Cell Adhesion D058266:Dielectric Spectroscopy D004563:Electrochemistry D005340:Fibrinogen D006801:Humans D007770:L-Lactate Dehydrogenase D010314:Partial Thromboplastin Time D056951:Photoelectron Spectroscopy D012666:Semiconductors D013918:Thrombin Time D014025:Titanium D014961:X-Ray Diffraction
electrochemical behavior Anti-thrombogenicity titanium oxide film biomaterials-associated thrombosis blood compatibility interfacial charge transfer