Non-alcoholic fatty liver and lipid profile status in patients with melasma: A case-control study.
BACKGROUND
There are pieces of evidence regarding the association between melasma and metabolic syndrome. To assess the prevalence and grade of nonalcoholic fatty liver and lipid profile status in patients with melasma, we designed this case-control study.


METHODS
This study was performed on 30 consecutive women with melasma who referred to the dermatology clinic of the hospital as the case group and 34 healthy women. For all participants, serum lipid profiles and liver enzymes were checked. Also, the existence of fatty liver was assessed by ultrasonography.


RESULTS
Except for serum level of LDL (low-density lipoprotein) that was significantly higher in the melasma group than in the healthy group (104.23 ± 25.00 mg/dl versus 89.85 ± 23.00 mg/dl, p = 0.020), the level of other parameters including other lipid profiles, blood sugar, or liver enzymes was similar in both groups. In ultrasonography, the overall prevalence of fatty liver was 23.3% in the melasma group and 20.6% in the control group, and no difference was found between the two groups in grade of fatty liver (p = 0.791).


CONCLUSION
The study showed a higher serum LDL level in patients with melasma compared to women without melasma, but there was no difference between the groups in prevalence or grade of fatty liver.
['Ghassemi|Mohammadreza|M|', 'Hosseinchi|Saba|S|', 'Seirafianpour|Farnoosh|F|', 'Dodangeh|Milad|M|', 'Goodarzi|Azadeh|A|https://orcid.org/0000-0002-1249-4429']
D016022:Case-Control Studies D005260:Female D006801:Humans D008055:Lipids D008548:Melanosis D065626:Non-alcoholic Fatty Liver Disease D014463:Ultrasonography
fatty liver lipid lipid profile melasma case-control study metabolic syndrome liver enzymes low-density lipoprotein hyperpigmented