Association of serum levels of perfluoroalkyl substances with gestational diabetes mellitus and postpartum blood glucose.
This study was conducted to examine the association of perfluoroalkyl substance (PFAS) exposure with gestational diabetes mellitus (GDM) risk and postpartum fasting blood glucose. We used a 1:2 matched case-control study with 84 GDM subjects and 168 healthy pregnant women from Beijing, China. The maternal blood was collected at 1-2days before delivery, and eight linear isomers and fourteen branched isomers were determined in maternal serum. Logistic regression analyses were performed to evaluate the associations after adjusting for potential confounders. The median of the sum of levels of total PFASs was 4.24ng/mL with a interquartile range (IQR) of 2.82-6.54ng/mL. Although maternal PFAS exposure was not associated with risk of GDM, significant positive associations were observed between evaluated exposure to specific PFAS congeners and increasing blood glucose. The odds ratio (ORs) of the highest category of postpartum fasting blood glucose for perfluoro-1-metylheptylsulfonat (1m-PFOS), perfluoro-3/4-metylheptylsulfonat (3m+4m-PFOS), perfluoro-5-metylheptylsulfonat (5m-PFOS), and perfluorohexane sulfonate (PFHxS) were 2.03 (95% CI: 1.09-3.77), 1.93 (95% CI: 1.04-3.58), 2.48 (95% CI: 1.33-4.65), and 2.26 (95% CI: 1.21-4.21), respectively, suggesting negative effects of maternal exposure to specific PFAS compounds on glucose metabolism.
['Wang|Yuxin|Y|', 'Zhang|Lei|L|', 'Teng|Yue|Y|', 'Zhang|Jiayu|J|', 'Yang|Lin|L|', 'Li|Jingguang|J|', 'Lai|Jianqiang|J|', 'Zhao|Yunfeng|Y|', 'Wu|Yongning|Y|']
D000328:Adult D017738:Alkanesulfonic Acids D000068476:Beijing D001786:Blood Glucose D016022:Case-Control Studies D016640:Diabetes, Gestational D004785:Environmental Pollutants D005260:Female D005466:Fluorocarbons D006801:Humans D018811:Maternal Exposure D049590:Postpartum Period D011247:Pregnancy
Perfluoroalkyl substances Gestational diabetes mellitus Blood glucose