Sequential use of Foley catheter with misoprostol for second trimester pregnancy termination in women with and without caesarean scars: a prospective cohort study.
PURPOSE
The aim of this study is to evaluate the effectiveness and safety of misoprostol and Foley catheter in second trimester termination in women with and without caesarean section (CS) scars.


MATERIALS AND METHODS
Women with an indication for pregnancy termination between 14 and 22 completed weeks of gestation were included to the study. Enrolled women were allocated into three groups: (1) women with no history of CS, (2) women with one CS and (3) women with ≥2 CS. Study consisted 337 patients (233 group 1, 88 group 2 and 16 group 3). Misoprostol and Foley catheter were used sequentially. The primary outcome was the induction to abortion interval. Secondary outcomes were the successful vaginal abortion rate, the percentage of abortions in 24 h and the rates of surgical removal of the placenta, Foley catheter use and major maternal complications (transfusions, thromboembolic events, uterine rupture and death).


RESULTS
Demographic characteristics were comparable. All study outcomes were statistically similar among groups. There was no major maternal complication among all patients.


CONCLUSIONS
Sequential use of misoprostol and Foley catheter is safe and effective in second trimester pregnancy termination for patients with and without CS scars.
['Velipasaoglu|Melih|M|', 'Ozdemir|Cem Yagmur|CY|', 'Ozek|Burcu|B|', 'Ayaz|Reyhan|R|', 'Tanir|Huseyin Mete|HM|']
D000020:Abortifacient Agents, Nonsteroidal D000028:Abortion, Induced D000328:Adult D002404:Catheterization D057785:Catheters D002585:Cesarean Section D002921:Cicatrix D005260:Female D005500:Follow-Up Studies D006801:Humans D016595:Misoprostol D011183:Postoperative Complications D011247:Pregnancy D011262:Pregnancy Trimester, Second D011446:Prospective Studies
Foley catheter misoprostol uterine rupture Medical abortion uterine scar