Safety and effectiveness of propofol sedation during and after outpatient colonoscopy.
AIM
To study the safety and effectiveness of propofol sedation for outpatient colonoscopy.


METHODS
Propofol was given by bolus injection with an age-adjusted standard protocol consisting of 60 mg for patients < 70 years old, 40 mg for patients age 70-89 years, and 20 mg for those ≥ 90 years, and additional injections of 20 mg propofol were given up to a maximum of 200 mg. The principal parameters were the occurrence of adverse events within 24 h after colonoscopy and overall satisfaction for this procedure. Secondary parameters included successful procedure, respiratory depression, and other complications.


RESULTS
Consecutive patients were entered prospectively and all 2101 entered successfully completed outpatient colonoscopy. The mean dose of propofol used was 96.4 mg (range 40-200 mg). Younger patients required higher doses of propofol than older patients (20-40 years vs ≥ 61 years: 115.3 ± 32 mg vs 89.7 ± 21 mg, P < 0.001). Transient supplemental oxygen supply was needed by five patients (0.2%); no other complications occurred. The questionnaires were completed by 1820 (87%) of 2101 patients and most rated their overall satisfaction as excellent (80%) or good (17%). The majority (65%) of patients drove home or to their office after their colonoscopy. Most (99%) were willing to repeat the same procedure. No incidents occurred within 24 h after colonoscopy.


CONCLUSION
Propofol sedation using a dose < 200 mg proved both safe and practical for outpatient colonoscopy.
['Horiuchi|Akira|A|', 'Nakayama|Yoshiko|Y|', 'Kajiyama|Masashi|M|', 'Kato|Naoyuki|N|', 'Kamijima|Tetsuya|T|', 'Ichise|Yasuyuki|Y|', 'Tanaka|Naoki|N|']
D000328:Adult D000367:Age Factors D000368:Aged D000369:Aged, 80 and over D018686:Anesthetics, Intravenous D003113:Colonoscopy D016292:Conscious Sedation D004724:Endoscopy D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D010045:Outpatients D010100:Oxygen D015742:Propofol D011446:Prospective Studies
Propofol Colonoscopy Colorectal cancer