Objectively measured sleep duration and plasma glucose values following an oral glucose tolerance test amongst pregnant women with obesity in the UK.
BACKGROUND/OBJECTIVES
Short sleep duration has been linked to maternal hyperglycaemia following a 1-h 50 g oral glucose tolerance test (OGTT) in observational studies conducted primarily in the USA. Our objective was to examine the relationship between objectively measured sleep duration and plasma glucose values following the 2-h 75 g OGTT routinely used in the UK amongst women with obesity.


METHODS
Sleep and OGTT data were available for 49 pregnant women who wore wrist actigraphs for at least two nights, and took a 2-h 75 g OGTT at the end of their second trimester. Multivariable regression was used to evaluate associations between sleep duration and OGTT results.


RESULTS
Higher 2-h plasma glucose values were significantly associated with shorter sleep duration and higher maternal age and BMI, with no association observed between wake after sleep onset (WASO) and 2-h plasma glucose values. No associations were observed between fasting plasma glucose values and any sleep parameters.


CONCLUSIONS
We found that shorter sleep duration, as measured using actigraphy, is associated with higher 2-h plasma glucose values following a 2-h 75 g OGTT in the UK. These findings are in keeping with those observed elsewhere in the world, employing alternative OGTT protocols. Future studies should investigate sleep extension as a potential candidate for inclusion in future RCTs aiming to improve glucose tolerance and prevent GDM amongst those at risk.
['Redfern|Kathy M|KM|', 'Hine|Rachel S|RS|', 'Hollands|Heidi J|HJ|', 'Welch|C Ross|CR|', 'Pinkney|Jonathan H|JH|', 'Rees|Gail A|GA|']
D056044:Actigraphy D000328:Adult D001786:Blood Glucose D016640:Diabetes, Gestational D005260:Female D000078064:Gestational Weight Gain D005951:Glucose Tolerance Test D006801:Humans D009765:Obesity D011247:Pregnancy D012890:Sleep
Sleep duration Glucose tolerance Obesity Actigraphy Pregnancy