Endothelial cell activation in central nervous system inflammation.
Leukocyte migration across the endothelial barrier plays an essential role in CNS inflammation. The migration process requires complex endothelial adhesion molecules concentrated at the junctions of endothelial cells. Recent findings suggest that cerebral endothelial cells play an active role in the pathogenesis of CNS inflammatory diseases. This review describes our current understanding of the effects of various inflammatory mediators of leukocyte migration on cerebral endothelial cells, the mechanisms underlying the leukocyte-endothelial cell interactions, and the crosstalk between endothelial cells and glial cells or platelets. These emerging mechanisms may provide new therapeutic strategies for a variety of CNS inflammatory diseases.
['Wu|Fengjiao|F|', 'Liu|Lixin|L|', 'Zhou|Hong|H|']
D000818:Animals D001792:Blood Platelets D001812:Blood-Brain Barrier D001921:Brain D002450:Cell Communication D002465:Cell Movement D016207:Cytokines D042783:Endothelial Cells D004730:Endothelium, Vascular D005786:Gene Expression Regulation D006801:Humans D007249:Inflammation D016023:Integrins D007962:Leukocytes D009457:Neuroglia D019087:Selectins
endothelial cell central nervous system inflammation leukocyte migration adhesion molecules