Hippocampal volume in subjects at clinical high-risk for psychosis: A systematic review and meta-analysis.
Several magnetic resonance imaging studies have reported reductions in hippocampal volume in patients with psychosis. It is unclear whether structural abnormalities predate illness onset. We conducted a detailed, systematic literature search for studies reporting hippocampal volume in subjects with clinical high-risk, compared to healthy controls. The overall sample size comprised 1429 subjects. Meta-analysis revealed no difference for left, but a small, albeit significant, difference for right hippocampal volume, such that clinical high-risk patients had slightly smaller hippocampal volume than healthy controls (g=0.24, p=0.0418). Meta-regression indicated a moderating effect of manual tracing approach, due to one outlying site. The small difference on the right side did not remain significant (g=0.14, 95%CI=[-0.03-0.32], p=0.11) after removal of this outlier. This meta-analysis suggests that there is no reduction in hippocampal volume before transition to psychosis and hippocampal volume cannot be used as a biomarker in clinical high-risk individuals.
['Walter|Anna|A|', 'Suenderhauf|Claudia|C|', 'Harrisberger|Fabienne|F|', 'Lenz|Claudia|C|', 'Smieskova|Renata|R|', 'Chung|Yoonho|Y|', 'Cannon|Tyrone D|TD|', 'Bearden|Carrie E|CE|', 'Rapp|Charlotte|C|', 'Bendfeldt|Kerstin|K|', 'Borgwardt|Stefan|S|', 'Vogel|Tobias|T|']
D007839:Functional Laterality D006624:Hippocampus D006801:Humans D008279:Magnetic Resonance Imaging D011618:Psychotic Disorders D012559:Schizophrenia
Clinical high-risk Psychosis Magnetic resonance imaging Biomarker At-risk mental state Early detection Hippocampus Ultra high-risk