N,N-dimethylhexadecyl carboxymethyl chitosan as a potential carrier agent for rotenone.
In this study, an amphiphilic chitosan derivative namely N,N-dimethylhexadecyl carboxymethyl chitosan (DCMC) was synthesised and applied for the first time as a carrier agent for rotenone. The physical and chemical properties of DCMC were characterised by using Fourier Transform Infrared Spectrometer (FTIR), Proton Nuclear Magnetic Resonance Spectrometer ((1)H NMR), CHN-O Elemental Analyser, Thermogravimetric Analyser (TGA) and Differential Scanning Calorimeter (DSC). DCMC was soluble in acidic (except pH 4), neutral and basic media with percent of transmittance (%T) values ranged from 67.2 to 99.4%. The critical micelle concentration (CMC) was determined as 0.095mg/mL. Transmission Electron Microscopy (TEM) analysis confirmed that DCMC has formed self-aggregates and exhibited spherical shape with the size of 65.5-137.0nm. The encapsulation efficiency (EE) and loading capacity (LC) of DCMC micelles with different weight ratios (DCMC:rotenone; 5:1, 50:1 and 100:1) were determined by using High Performance Liquid Chromatography (HPLC). The weight ratio of 100:1 gave the best EE with the value of more than 95.0%. DCMC micelles performed an excellent ability to control the release of rotenone, of which 99.0% of rotenone was released within 48h. Overall, DCMC has several key features to be an effective carrier agent for pesticide formulations.
['Kamari|A|A|', 'Aljafree|N F A|NF|', 'Yusoff|S N M|SN|']
D048271:Chitosan D004337:Drug Carriers D004339:Drug Compounding D065546:Drug Liberation D006863:Hydrogen-Ion Concentration D057927:Hydrophobic and Hydrophilic Interactions D007306:Insecticides D007700:Kinetics D008823:Micelles D010316:Particle Size D012402:Rotenone D014475:Uncoupling Agents
N,N-dimethylhexadecyl carboxymethyl chitosan Chitosan Carrier Rotenone Micelles