Hypertension, lipoprotein subclasses and lipid transfer proteins in obese children and adolescents.
BACKGROUND
Obesity-related childhood hypertension is associated with disturbances of serum lipids, but less is known about distribution of lipoprotein subclasses and activities of proteins involved in reverse cholesterol transport in hypertensive obese children. Our objective was to determine low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subclasses distribution and activities of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer protein (CETP) in hypertensive and non-hypertensive obese children.


METHODS
A total of 40 hypertensive and 25 non-hypertensive obese children were enrolled. Lipoprotein subclasses were assessed by polyacrylamide gradient gel electrophoresis. LCAT and CETP activities were determined as a rate of formation and a rate of transfer of cholesteryl esters.


RESULTS
Despite of comparable values of serum lipid parameters, a shift toward smaller LDL and HDL subclasses was observed in hypertensive compared to normotensive obese children. Activities of LCAT were similar, but proatherogenic CETP activities were significantly higher in the hypertensive group (p = 0.036). LCAT/net CETP ratio inversely correlated with relative proportion of small, dense LDL particles (ρ = -0.423; p = 0.025) in the group with hypertension.


CONCLUSIONS
The results of our study demonstrated a tendency toward altered distribution of lipoprotein subclasses in favor of more proatherogenic particles in childhood hypertension. Also, hypertensive obese children had increased proatherogenic CETP activity.
['Bekhet|Osama H|OH|', 'Zeljkovic|Aleksandra|A|', 'Vekic|Jelena|J|', 'Paripovic|Dusan|D|', 'Janac|Jelena|J|', 'Joksic|Jelena|J|', 'Gojkovic|Tamara|T|', 'Spasojevic-Kalimanovska|Vesna|V|', 'Peco-Antic|Amira|A|', 'Milosevski-Lomic|Gordana|G|', 'Jelic-Ivanovic|Zorana|Z|']
D000293:Adolescent D015415:Biomarkers D002648:Child D053480:Cholesterol Ester Transfer Proteins D005260:Female D006801:Humans D006973:Hypertension D008075:Lipoproteins, HDL D008077:Lipoproteins, LDL D008297:Male D063766:Pediatric Obesity D007862:Phosphatidylcholine-Sterol O-Acyltransferase D055815:Young Adult
hypertension LCAT CETP LDL and HDL subclasses childhood obesity