The effects of microduplication 1q21.1 and in-utero isotretinoin exposure.
The impact of in-utero isotretinoin exposure has been widely reported, with many affected pregnancies failing to reach term.1 2 Due to the low numbers of in-utero isotretinoin exposed pregnancies, the interactions between this drug and rare genetic defects such as microduplication 1q21.1 are unclear, particularly how they might manifest phenotypically. We present this case of in-utero isotretinoin exposure occurring in a child with microduplication 1q21.1. The child was born with congenital abnormalities which did not fit into a single syndrome. Regrettably in-utero exposure to isotretinoin continues to occur. We hope this case will trigger further discussion on the dangers of dispensing Isotretinoin without ensuring stringent pregnancy testing and its potential interaction with genetic abnormalities, in particular with microduplication 1q21.1.
['Taylor|Sarah Kirsten|SK|', 'Toko|Remy|R|']
D000014:Abnormalities, Drug-Induced D002971:Cleft Lip D002972:Cleft Palate D003937:Diagnosis, Differential D005260:Female D005385:Fingers D006801:Humans D007223:Infant D015474:Isotretinoin D008279:Magnetic Resonance Imaging D011247:Pregnancy D011297:Prenatal Exposure Delayed Effects D013576:Syndactyly D013723:Teratogens D014034:Toes
Contraindications And Precautions Drugs: Obstetrics And Gynaecology Paediatrics