Guided Cell Attachment via Aligned Electrospinning of Glycopolymers.
The creation of biomaterials with aligned fibers offers broad applications in tissue regeneration, guiding cell organization and physiological cues, and providing appropriate mechanical properties for many biomedical applications. Herein, for the first time, highly aligned electrospun membranes are designed and developed using glycopolymers. The membranes retain the strong mechanical properties of polycaprolactone, and fiber alignment facilitates the creation of anisotropic mechanical properties, enabling failure stress to be manipulated by an order of magnitude relative to randomly ordered fibers. Biocompatibility and cell attachment in these materials are characterized using tenocytes as a cell model. Both random and aligned fiber glycopolymers show promising biocompatibility, but aligned glycopolymer fibers additionally offer patterning to guide cell organization. These materials potentially provide a novel platform for tissue regeneration studies, demonstrating that the sugar-lectin interaction can produce materials capable of managing cell guidance.
['Liu|Renjie|R|0000-0002-3885-244X', 'Becer|Caglar Remzi|CR|0000-0003-0968-6662', 'Screen|Hazel R C|HRC|0000-0002-9077-0732']
D000818:Animals D001672:Biocompatible Materials D002417:Cattle D002448:Cell Adhesion D002470:Cell Survival D055664:Electrochemical Techniques D006801:Humans D008422:Materials Testing D008567:Membranes, Artificial D011091:Polyesters D011137:Polystyrenes D061251:Primary Cell Culture D000070916:Tenocytes D013718:Tensile Strength D023822:Tissue Engineering D054457:Tissue Scaffolds
electrospinning glycopolymer cell alignment para-fluoro thiol click reaction tendon repair