Sesamin Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibition of TLR4 Signaling Pathways.
Recent studies suggested that TLR4 signaling pathways played an important role in the development of LPS-induced acute lung injury (ALI). Sesamin, a sesame lignan exacted from sesame seeds, has been shown to exhibit significant anti-inflammatory activity. The purpose of this study was to investigate the anti-inflammatory effects of sesamin on LPS-induced ALI in mice. Mice ALI model was induced by intratracheal instillation of LPS. Sesamin was given 1 h after LPS challenge. Our results showed that sesamin inhibited LPS-induced lung pathological change, edema, and myeloperoxidase (MPO) activity. Sesamin suppressed LPS-induced inflammatory cytokines TNF-α, IL-6, and IL-1β production. Furthermore, sesamin inhibited LPS-induced TLR4 expression and NF-κB activation. In conclusion, the results of this study indicated that sesamin protected against LPS-induced ALI by inhibition of TLR4 signaling pathways.
['Qiang|Li|L|', 'Yuan|Jiang|J|', 'Shouyin|Jiang|J|', 'Yulin|Li|L|', 'Libing|Jiang|J|', 'Jian-An|Wang|W|']
D055371:Acute Lung Injury D000818:Animals D000893:Anti-Inflammatory Agents D004149:Dioxoles D004487:Edema D004789:Enzyme Activation D053583:Interleukin-1beta D015850:Interleukin-6 D017705:Lignans D008070:Lipopolysaccharides D008168:Lung D008297:Male D051379:Mice D008807:Mice, Inbred BALB C D016328:NF-kappa B D009195:Peroxidase D015398:Signal Transduction D051197:Toll-Like Receptor 4 D014409:Tumor Necrosis Factor-alpha
sesamin acute lung injury TLR4 LPS NF-κB