Effects of PMS50 supplementation on psychological symptoms of students with premenstrual syndrome.
OBJECTIVE
To evaluate the effects of PMS50 supplementation on psychological symptoms in university students in Iran.


METHODS
This double-blind clinical trial was conducted at Ahvaz Jundishapur University of Medical Sciences, between December 2018 and March 2019. Fifty female students with moderate to severe premenstrual syndrome (PMS) randomly received either 550 mg/day of PMS50 (n = 25) or placebo (n = 25), starting from 1 week before till the end of menstruation for three consecutive menstrual cycles. Anthropometric indices, dietary intake, physical activity level, and severity of PMS were assessed at baseline and post-intervention. Data were analyzed by SPSS (version 22). Independent t test was used to compare the results between groups. Paired t test was used to compare the results within groups before and after study.


RESULTS
There was a significant improvement in psychological symptoms including depression, anger, feeling of hopelessness, desire to be alone, mood swings, irritability, anxiety, and poor concentration observed in the intervention group compared with the control group post-intervention. Restlessness was significantly reduced in both groups post-intervention. The mean scores of low self-esteem, change in appetite, and food cravings were decreased in both groups, but not significant between groups.


CONCLUSION
PMS50 supplementation may be effective in improvement of psychological symptoms in PMS. Clinical Trial Registration No.: IRCT20181218042038 N1.
['Sadeghi|Fatemeh|F|', 'Javid|Ahmad Zare|AZ|https://orcid.org/0000-0001-7119-7582', 'Nazarinasab|Masoumeh|M|', 'Haghighi-Zadeh|Mohammad Hosein|MH|']
PMS50 supplement psychological symptoms premenstrual syndrome