Are targeted prostate biopsies ready to replace systematic prostate biopsies?
OBJECTIVES
To evaluate the efficacy and efficiency of systematic prostatic biopsy (SPB) and cognitive fusion PB (CFPB) to diagnose prostate cancer (PCa) and significant PCa (SPCa), and to analyse if CFPB could safely replace SPB.


MATERIAL AND METHODS
A cohort of 314 consecutive men having PI-RADS ≥2 in a pre-biopsy 3T mp-MRI were prospectively subjected to trans-rectal ultrasound CFPB (two cores per suspicious area until a maximum of three areas) and a 12 peripheral core SPB. SPCa was considered when the WHO grade was higher than 2 (Gleason 4+3 or higher).


RESULTS
PCa was diagnosed in 133 patients (42.4%), being 83 (62.4%) SPCa. SPB detected PCa in 114 men (85.7%) while CFPB in 103 (77.4%), P<.001. SPB detected SPCa in 64 men (77.1%) while CFPB in 71 (85.5%), P<.001. In 52 of the 81 men (64.2%) SPCa was detected in SPB and CFPB. In 19 men SPCa was only detected in CFPB (23.5%) while in 10, it was only detected in SPB (12.3%). 33.1 cores were needed to diagnose one PCa in SPB while 8.5 in CFPB, P<.001. 58.9 cores were needed to diagnose one SPCa in SPB, while 12.4 in CFPB, P<.001.


CONCLUSIONS
CFPB are more effective and also more efficient than SPBs in detecting SPCa. However, CFPBs still can't safely replace SPBs because they are not able to detect up to 15% of SPCa.
['Celma|A|A|', 'López|R|R|', 'Roche|S|S|', 'Planas|J|J|', 'Regis|L|L|', 'Placer|J|J|', 'Borque|A|A|', 'Esteban|L M|LM|', 'de Torres|I|I|', 'Morote|J|J|']
D000368:Aged D001706:Biopsy D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration D006801:Humans D061705:Image-Guided Biopsy D007610:Kallikreins D053783:Magnetic Resonance Imaging, Interventional D008297:Male D008875:Middle Aged D060787:Neoplasm Grading D011446:Prospective Studies D011467:Prostate D017430:Prostate-Specific Antigen D011471:Prostatic Neoplasms
Targeted prostate biopsies Prostate cancer Biopsias de próstata dirigidas Biopsias dirigidas a fusión cognitiva Cognitive fusion targeted biopsies Cáncer de próstata Multi-parametric MRI Resonancia magnética multiparamétrica