Narrow SAR in odorant sensing Orco receptor agonists.
The systematic exploration of a series of triazole-based agonists of the cation channel insect odorant receptor is reported. The structure-activity relationships of independent sections of the molecules are examined. Very small changes to the compound structure were found to exert a large impact on compound activity. Optimal substitutions were combined using a 'mix-and-match' strategy to produce best-in-class compounds that are capable of potently agonizing odorant receptor activity and may form the basis for the identification of a new mode of insect behavior modification.
['Romaine|Ian M|IM|', 'Taylor|Robert W|RW|', 'Saidu|Samsudeen P|SP|', 'Kim|Kwangho|K|', 'Sulikowski|Gary A|GA|', 'Zwiebel|Laurence J|LJ|', 'Waterson|Alex G|AG|']
D000818:Animals D004331:Drosophila melanogaster D007211:Indoles D015394:Molecular Structure D018035:Receptors, Odorant D013329:Structure-Activity Relationship D014230:Triazoles
Odorant receptor Drosophila melanogaster Structure activity relationship VUAA1