Testing Albendazole Resistance in Fasciola hepatica.
The egg development test is a useful in vitro tool to detect albendazole (ABZ) resistance in Fasciola hepatica. ABZ is the only flukicidal compound with ovicidal activity. The described test is based on the ABZ capacity to affect parasite egg development and hatching in susceptible parasites, while this effect is lost in ABZ-resistant liver fluke isolates. Among many advantages, it is noted that the diagnostic test can be performed on eggs isolated from fecal samples (sheep and cattle), avoiding the sacrifice of animals necessary in controlled efficacy trials. The egg development test described here is a simple, inexpensive, and accessible method, previously employed for diagnosis of ABZ resistance in F. hepatica.
['Alvarez|Luis I|LI|', 'Valladares|María Martinez|MM|', 'Canton|Candela|C|', 'Lanusse|Carlos E|CE|', 'Ceballos|Laura|L|']
D015766:Albendazole D000818:Animals D002417:Cattle D004351:Drug Resistance D004531:Eggs D005210:Fasciola hepatica D005211:Fascioliasis D005243:Feces D012756:Sheep D012757:Sheep Diseases
Albendazole Resistance Fasciola hepatica Egg development test Ovicidal activity Diagnostic