Remineralizing potential of CPP-ACP applied for 1 min in vitro.
AIM
To evaluate (1) the remineralizing potential of Tooth Mousse(®) (TM) on artificial carious lesions, when applied for 1 min, and (2) the benefit of a fluoridated dentifrice prior to TM application.


METHODS
Demineralisation caries-like lesions 120-200 μm deep were produced by placing molars in demineralizing solution for 96 h, sections 100-150 μm thick were then randomly assigned to four groups. Specimens were treated thrice daily with a non-fluoridated (Group A), or fluoridated dentifrice (1000 ppm) (Group B), or TM (Group C), or a fluoridated dentifrice followed by TM (Group D) then subjected to a 10-day pH cycling model. Lesion evaluation involved polarizing light microscopy and microradiography.


RESULTS
Application of TM in isolation (Group C) for 1 min resulted in significant increase in lesion depth (LD), however, an increase in mineral content deposition (V max) was not significant. Post treatment LD increases were greatest in Group A, then Group C and Group B respectively. A decrease in LD (by 19.9 %) was noted only after fluoridated dentifrice and TM (Group D) were applied consecutively for 1 min each (p < 0.05). Mineral content deposition was also greatest in this group (Group D) and both V max and LD changes were statistically significant when compared to other groups.


CONCLUSIONS
TM alone failed to remineralize carious lesions when applied for 1 min. However, remineralization occurred after a prior application of a fluoridated dentifrice.
['Gopalakrishnan|V|V|', 'Anthonappa|R P|RP|', 'King|N M|NM|', 'Itthagarun|A|A|']
D002327:Cariostatic Agents D002364:Caseins D003731:Dental Caries D003743:Dental Enamel D005459:Fluorides D006801:Humans D006863:Hydrogen-Ion Concentration D066298:In Vitro Techniques D011897:Random Allocation D014089:Tooth Remineralization
Remineralization CPP-ACP Fluoride Dentifrice Demineralization Dental caries