Gene Expression Profiling Studies Using Microarray in Osteoarthritis: Genes in Common and Different Conditions.
Osteoarthritis (OA), which is characterized mainly by cartilage degradation, is the most prevalent joint disorder worldwide. Although OA is identified as a major cause of joint pain, disability, and socioeconomic burden, the etiology of OA is still not clearly known. Recently, gene microarray analysis has become an efficient method for the research of complex diseases and has been employed to determine what genes and pathways are involved in the pathological process of OA. In this review, OA study results over the last decade are summarized for gene expression profiling of various tissues, such as cartilage, subchondral bone, and synovium in human OA and mouse OA models. Many differentially expressed genes, which mainly involve matrix metabolism, bone turnover, and inflammation pathways, were identified in diseased compared with "normal" tissues. Nevertheless, rare common genes were reported from studies using different tissue sources, microarray chips, and research designs. Thus, future novel and carefully designed microarray studies are required to elucidate underlying genetic mechanisms in the pathogenesis of OA as well as new directions for potential OA-targeted pharmaceutical therapies.
['Liu|Weidong|W|', 'Jiao|Yan|Y|', 'Tian|Cheng|C|', 'Hasty|Karen|K|', 'Song|Lijie|L|', 'Kelly|Derek M|DM|', 'Li|Jianwei|J|', 'Chen|Hong|H|', 'Gu|Weikuan|W|http://orcid.org/0000-0003-1112-8088', 'Liu|Songjiang|S|']
D000818:Animals D001842:Bone and Bones D002358:Cartilage, Articular D004195:Disease Models, Animal D020869:Gene Expression Profiling D006801:Humans D007249:Inflammation D007596:Joints D046228:Microarray Analysis D010003:Osteoarthritis D000081246:RNA-Seq D013583:Synovial Membrane
Gene expression profiles Osteoarthritis Subchondral bone Synovium Articular cartilage