Potential applications of image-guided radiotherapy for radiation dose escalation in patients with early stage high-risk prostate cancer.
Patients with early stage high-risk prostate cancer (prostate specific antigen > 20, Gleason score > 7) are at high risk of recurrence following prostate cancer irradiation. Radiation dose escalation to the prostate may improve biochemical-free survival for these patients. However, high rectal and bladder dose with conventional three-dimensional conformal radiotherapy may lead to excessive gastrointestinal and genitourinary toxicity. Image-guided radiotherapy (IGRT), by virtue of combining the steep dose gradient of intensity-modulated radiotherapy and daily pretreatment imaging, may allow for radiation dose escalation and decreased treatment morbidity. Reduced treatment time is feasible with hypo-fractionated IGRT and it may improve patient quality of life.
['Nguyen|Nam P|NP|', 'Davis|Rick|R|', 'Bose|Satya R|SR|', 'Dutta|Suresh|S|', 'Vinh-Hung|Vincent|V|', 'Chi|Alexander|A|', 'Godinez|Juan|J|', 'Desai|Anand|A|', 'Woods|William|W|', 'Altdorfer|Gabor|G|', "D'Andrea|Mark|M|", 'Karlsson|Ulf|U|', 'Vo|Richard A|RA|', 'Sroka|Thomas|T|', '|||']
image-guided radiotherapy high-risk prostate cancer hypofractionation