Leptin enhances the invasive ability of glioma stem-like cells depending on leptin receptor expression.
Glioma stem-like cells have been demonstrated to have highly invasive activity, which is the major cause of glioma recurrence after therapy. Leptin plays a role in glioma invasion, however, whether and how leptin contributes to the biological properties of glioma stem-like cells, such as invasion, remains to be explored. In the current study, we aimed to explore the role of leptin during glioma stem-like cells invasion as well as the signaling pathway. We found that glioma stem-like cells exhibited high invasive potential, especially in the presence of leptin, Ob-R coexpressed with CD133 in glioma stem-like cells was showed to be responsible for leptin mediated invasion of glioma stem-like cells. Our results indicated that leptin served as a key intermediary linking the accumulation of excess adipokine to the invasion of glioma stem-like cells, which may be a novel therapeutic target for suppressing tumor invasion and recurrence.
['Han|Guosheng|G|', 'Zhao|Wenyuan|W|', 'Wang|Laixing|L|', 'Yue|Zhijian|Z|', 'Zhao|Rui|R|', 'Li|Yanan|Y|', 'Zhou|Xiaoping|X|', 'Hu|Xiaowu|X|', 'Liu|Jianmin|J|']
D000071916:AC133 Antigen D015703:Antigens, CD D001932:Brain Neoplasms D002465:Cell Movement D002867:Chromones D003114:Colony-Forming Units Assay D004791:Enzyme Inhibitors D015972:Gene Expression Regulation, Neoplastic D005910:Glioma D006023:Glycoproteins D006801:Humans D020738:Leptin D020780:Matrix Metalloproteinase 9 D009025:Morpholines D009361:Neoplasm Invasiveness D014411:Neoplastic Stem Cells D009930:Organic Chemicals D010455:Peptides D034741:RNA, Small Interfering D054411:Receptors, Leptin D050796:STAT3 Transcription Factor D015398:Signal Transduction D014407:Tumor Cells, Cultured
Leptin Invasion Glioma stem-like cells Leptin receptor