The relationship between the number of examined lymph nodes and the efficacy of chemotherapy for gastric cancer.
BACKGROUND
The purpose of this research was to investigate the relationship between the number of examined lymph nodes (eLNs) and the prognosis.


METHODS
A retrospective examination of reports and studies carried out at two institutions was conducted. According to TNM stages, the relationship between the number of eLNs and the prognosis was analyzed.


RESULTS
The 5-year disease-specific survival (DSS) of all enrolled patients was 66.3%. A multivariate analysis showed the type of gastrectomy, histologic type, perineural invasion, pT stage, pN stage, chemotherapy and eLNs to be independent prognostic markers. Additionally, with the exception of patients with stage I disease, the 5-year DSS of patients who had < 25 eLNs removed had a higher risk of having a worst prognosis compared to patients who had ≥ 25 eLNs removed. Through this study, a hypothetical TNM staging system was obtained for predicting the prognosis according to the number of eLNs. Chemotherapy was able to improve the prognosis of patients with stage III and < 25 eLNs in stage II.


CONCLUSIONS
Extended lymphadenectomy with a new goal of dissecting 25 LNs for the evaluation of stage II-III cancer cases is recommended. Our hypothetical TNM staging system may be able to stratify the risk more accurately compared to the current AJCC 8th system. Chemotherapy can improve the prognosis in advanced gastric cancer, but its benefit may be affected by the surgical quality.
['Gu|Lihu|L|', 'Chen|Bangsheng|B|', 'Shen|Zefeng|Z|', 'Khadaroo|Parikshit Asutosh|PA|', 'Wang|Xianfa|X|', 'Zhu|Hepan|H|', 'Pan|Junhai|J|', 'Zhong|Xin|X|', 'Mao|Feiyan|F|', 'Chen|Ping|P|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D005260:Female D006801:Humans D008197:Lymph Node Excision D008198:Lymph Nodes D008297:Male D008875:Middle Aged D009367:Neoplasm Staging D011379:Prognosis D012189:Retrospective Studies D012306:Risk D013274:Stomach Neoplasms D055815:Young Adult
Chemotherapy Gastric cancer Prognostic marker Lymph node examination