Sex-specific differences in pulmonary embolism.
INTRODUCTION
Sex-specific differences regarding risk factors, symptoms and prognosis have been reported for several cardiovascular diseases. For patients with pulmonary embolism (PE), sex-specific data are limited and inconsistent. We aimed to investigate sex-specific differences in PE.


MATERIALS AND METHODS
Over a 10-year period (01/2003-09/2013), patients with confirmed PE were enrolled in a prospective single-centre cohort study.


RESULTS
We prospectively examined 569 PE patients (55.9% women). Men more often had cancer (20.7% vs. 13.5%, p = 0.024) and unprovoked PE (61.0% vs. 47.5%, p = 0.001) while women more frequently presented with risk factors for venous thromboembolism such as older age (median, 71 [IQR, 55-79] vs. 67 [53-75] years, p = 0.008), surgery/trauma/immobilisation (38.4% vs. 29.5%, p = 0.026) and sex-hormone therapy (14.8% vs. 0.8%, p < 0.001). Overall, 84 patients (14.8%) had an adverse 30-day outcome and 43 (7.6%) died within 30 days; outcomes did not differ between males and females and were not influenced by the patients' sex. Risk stratification markers and models such as right ventricular dysfunction on TTE/CT, cardiac troponin, sPESI, Bova score and 2014 ESC guidelines algorithm predicted adverse outcome in normotensive female patients only, while tachycardia, hypoxia, NT-proBNP and modified FAST score were able to predict an adverse outcome in both sexes. Using sex-specific biomarker cut-off values, the 2014 ESC guidelines algorithm was able to predict adverse outcome in both sexes.


CONCLUSIONS
The 30-day adverse outcomes did not differ between male and female PE patients and were not influenced by the patients' sex despite sex-specific differences in the prognostic performance of risk stratification markers/models.
['Keller|Karsten|K|', 'Rappold|Lisa|L|', 'Gerhold-Ay|Aslihan|A|', 'Hobohm|Lukas|L|', 'Hasenfuß|Gerd|G|', 'Konstantinides|Stavros V|SV|', 'Dellas|Claudia|C|', 'Lankeit|Mareike|M|']
D000368:Aged D015331:Cohort Studies D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D011446:Prospective Studies D011655:Pulmonary Embolism D012727:Sex Characteristics
Pulmonary embolism Prognosis Risk stratification Gender Mortality