Predictive factors of mortality in pediatric patients with acute renal injury associated with sepsis.
OBJECTIVE
To evaluate the prognosis factors of children with sepsis and acute kidney injury.


METHODS
This was a retrospective study of children with sepsis and acute kidney injury that were admitted to the pediatric intensive care unit (PICU) of a tertiary hospital. A multivariate analysis was performed to compare risk factors for mortality.


RESULTS
Seventy-seven children (47 males) were retrospectively studied, median age of 4 months. Mean length of hospital stay was 7.33±0.16 days, 68.9% of patients received mechanical ventilation, 25.9% had oligo-anuria, and peritoneal dialysis was performed in 42.8%. The pRIFLE criteria were: injury (5.2%) and failure (94.8%), and the staging system criteria were: stage 1 (14.3%), stage 2 (29.9%), and stage 3 (55.8%). The mortality rate was 33.7%. In the multivariate analysis, the risk factors for mortality were PICU length of stay (OR=0.615, SE=0.1377, 95% CI=0.469-0.805, p=0.0004); invasive mechanical ventilation (OR=14.599, SE=1.1178, 95% CI=1.673-133.7564, p=0.0155); need for dialysis (OR=9.714, SE=0.8088, 95% CI=1.990-47.410, p=0.0049), and hypoalbuminemia (OR=10.484, SE=1.1147, 95% CI=1.179-93.200, p=0.035).


CONCLUSIONS
The risk factors for mortality in children with acute kidney injury were associated with sepsis severity.
['Riyuzo|Marcia C|MC|', 'Silveira|Liciana V de A|LV|', 'Macedo|Célia S|CS|', 'Fioretto|José R|JR|']
D058186:Acute Kidney Injury D001938:Brazil D005260:Female D006801:Humans D007223:Infant D015278:Intensive Care Units, Pediatric D007902:Length of Stay D008297:Male D015999:Multivariate Analysis D011379:Prognosis D012189:Retrospective Studies D012307:Risk Factors D018805:Sepsis D016019:Survival Analysis
Predictive factors Mortality Sepsis Acute kidney injury Fatores preditivos Lesão renal aguda Mortalidade Sepse