Clinical characteristics and risk factors for mortality upon admission in patients with heart failure hospitalized due to COVID-19 in Spain.
BACKGROUND
There are few studies on patients with heart failure (HF) hospitalized for COVID-19. Our aim is to describe the clinical characteristics of patients with HF hospitalized for COVID-19 and identify risk factors for in-hospital mortality upon admission.


METHODS
We conducted a retrospective, multicenter study in patients with HF hospitalized for COVID-19 in 150 Spanish hospitals (SEMI-COVID-19 Registry). A multivariate logistic regression analysis was performed to identify admission factors associated with in-hospital mortality.


RESULTS
A total of 1718 patients were analyzed (56.5% men; median age 81.4 years). The overall case fatality rate was 47.6% (n = 819). The independent risk factors at admission for in-hospital mortality were: age (adjusted odds ratio [AOR]: 1.03; 95% confidence interval [95%CI]: 1.02-1.05; p < .001); severe dependence (AOR: 1.62; 95%CI: 1.19-2.20; p = .002); tachycardia (AOR: 1.01; 95%CI: 1.00-1.01; p = .004); and high C-reactive protein (AOR: 1.004; 95%CI:1.002-1.004; p < .001), LDH (AOR: 1.001; 95%CI: 1.001-1.002; p < .001), and serum creatinine levels (AOR: 1.35; 95%CI: 1.18-1.54; p < .001).


CONCLUSIONS
Patients with HF hospitalized for COVID-19 have a high in-hospital mortality rate. Some simple clinical and laboratory tests can help to identify patients with a worse prognosis.
['Salinas-Botrán|A|A|', 'Sanz-Cánovas|J|J|', 'Pérez-Somarriba|J|J|', 'Pérez-Belmonte|L M|LM|', 'Cobos-Palacios|L|L|', 'Rubio-Rivas|M|M|', 'de-Cossío-Tejido|S|S|', 'Ramos-Rincón|J M|JM|', 'Méndez-Bailón|M|M|', 'Gómez-Huelgas|R|R|', '|||']
Risk factor Mortality Heart failure Hospitalization Coronavirus disease-2019 Enfermedad por coronavirus-2019 Factor de riesgo Hospitalización Insuficiencia cardíaca Mortalidad