Protective potentials of far-infrared ray against neuropsychotoxic conditions.
Compelling evidence suggests that far-infrared ray (FIR) possesses beneficial effects on emotional disorders. However, the underlying mechanism conveyed by FIR remains unclear. Recently, we demonstrated that exposure to FIR induces antioxidant potentials via up-regulation of glutathione peroxidase (GPx)-1 gene. The antioxidant potentials might be important for the modulation on the neuropsychotoxic conditions. Exposure to FIR protects from methamphetamine (MA)-induced memory impairments via phosphorylation of ERK 1/2 signaling by positive modulation of protein kinase C δ (PKCδ), M1 muscarinic acetylcholine receptor (M1 mAChR), and nuclear factor E2-related factor 2 (Nrf2) transcription factor. In addition, exposure to FIR positively modulates MA-induced behavioral sensitization via attenuating mitochondrial dysfunction by down-regulation of dopamine D1 receptor. In this mini-review, we have discussed with the protective potentials mediated by FIR against MA-induced psychotoxic burdens.
['Sharma|Naveen|N|', 'Shin|Eun-Joo|EJ|', 'Kim|Nam Hun|NH|', 'Cho|Eun-Hee|EH|', 'Jeong|Ji Hoon|JH|', 'Jang|Choon-Gon|CG|', 'Nah|Seung-Yeol|SY|', 'Nabeshima|Toshitaka|T|', 'Yoneda|Yukio|Y|', 'Cadet|Jean Lud|JL|', 'Kim|Hyoung-Chun|HC|']
D000818:Animals D000975:Antioxidants D006801:Humans D007259:Infrared Rays D008694:Methamphetamine D008928:Mitochondria D051745:Protein Kinase C-delta D017447:Receptors, Dopamine D1
Far-infrared ray Methamphetamine Memory impairments Behavioral sensitization Glutathione peroxidase-1 gene