A new C-glycosyl flavone and a new neolignan glycoside from Passiflora edulis Sims peel.
A new C-glycosyl flavone, Chrysin-8-C-(2″-O-β-6-deoxy-glucopyranosyl)-β-D-glucopyranoside (1), a new neolignan glycoside, citrusin G (2), as well as 15 known compounds (3-17) were isolated from the peel of Passiflora edulis Sims. The structure determinations were primarily based on comprehensive spectroscopic analyses, and the absolute configuration of 2 were unequivocally determined by the CD experiment and chemical transformation. Compound 1 represents the rare examples of the flavonoid featuring a deoxy glucose sugar moiety. Compounds 5, 7 and 9 exhibited moderate inhibitory effects on nitric oxide (NO) production stimulated by lipopolysaccharide (LPS) in RAW 264.7 cells, with IC50 values of 34.92, 16.12 and 26.67 μM, respectively.
['Hu|Yue|Y|', 'Jiao|Lin|L|', 'Jiang|Min-Hong|MH|', 'Yin|Sheng|S|', 'Dong|Pan|P|', 'Zhao|Zhi-Min|ZM|', 'Yang|De-Po|DP|', 'Ho|Pei-Tsai|PT|', 'Wang|Dong-Mei|DM|']
D000818:Animals D047309:Flavones D006027:Glycosides D008070:Lipopolysaccharides D051379:Mice D015394:Molecular Structure D009569:Nitric Oxide D029598:Passiflora D010936:Plant Extracts D000067996:RAW 264.7 Cells D013057:Spectrum Analysis
C-glycosyl flavone neolignan glycoside Passiflora edulis Sims peel