Evolving pharmacology of orphan GPCRs: IUPHAR Commentary.
The award of the 2012 Nobel Prize in Chemistry to Robert Lefkowitz and Brian Kobilka for their work on the structure and function of GPCRs, spanning a period of more than 20 years from the cloning of the human β2 -adrenoceptor to determining the crystal structure of the same protein, has earned both researchers a much deserved place in the pantheon of major scientific discoveries. GPCRs comprise one of the largest families of proteins, controlling many major physiological processes and have been a major focus of the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) since its inception in 1987. We report here recent efforts by the British Pharmacological Society and NC-IUPHAR to define the endogenous ligands of 'orphan' GPCRs and to place authoritative and accessible information about these crucial therapeutic targets online.
['Davenport|Anthony P|AP|', 'Harmar|Anthony J|AJ|']
D022126:Access to Information D000818:Animals D003299:Cooperative Behavior D057166:High-Throughput Screening Assays D006801:Humans D007391:International Cooperation D008024:Ligands D057093:Orphan Nuclear Receptors D010600:Pharmacology D015398:Signal Transduction D012958:Societies, Scientific D009626:Terminology as Topic
chemerin receptor chemokine receptors free fatty acid receptors hydroxycarboxylic acid receptors lysophosphatidic acid receptors oxoglutarate receptor succinate receptor