Mammalian nonmuscle myosin II comes in three flavors.
Nonmuscle myosin II is an actin-based motor that executes numerous mechanical tasks in cells including spatiotemporal organization of the actin cytoskeleton, adhesion, migration, cytokinesis, tissue remodeling, and membrane trafficking. Nonmuscle myosin II is ubiquitously expressed in mammalian cells as a tissue-specific combination of three paralogs. Recent studies reveal novel specific aspects of their kinetics, intracellular regulation and functions. On the other hand, the three paralogs also can copolymerize and cooperate in cells. Here we review the recent advances from the prospective of how distinct features of the three myosin II paralogs adapt them to perform specialized and joint tasks in the cell.
['Shutova|Maria S|MS|', 'Svitkina|Tatyana M|TM|']
D008841:Actin Cytoskeleton D000199:Actins D000818:Animals D001696:Biomechanical Phenomena D002448:Cell Adhesion D002465:Cell Movement D048749:Cytokinesis D005057:Eukaryotic Cells D005109:Extracellular Matrix D015870:Gene Expression D006801:Humans D008322:Mammals D018995:Myosin Heavy Chains D024462:Myosin Type II D024507:Nonmuscle Myosin Type IIA D024501:Nonmuscle Myosin Type IIB D055503:Protein Multimerization
Myosin II Actin Cytoskeleton Stress fibers