Time trends analysis of statin prescription prevalence, therapy initiation, dose intensity, and utilization from the hospital information system of Jinshan Hospital, Shanghai (2012-2018).
BACKGROUND
Statin remains a mainstay in the prevention and treatment of cardiovascular diseases. Statin utilization has evolved over time in many countries, but data on this topic from China are quite limited. This study aimed to investigate the changing trends of statins prescription, as well as detail the statin utilization through a successive longitudinal study.


METHODS
The prescription database was established based on electronic health records retrieved from the hospital information system of Jinshan Hospital, Fudan University from January 2012 to December 2018 in Shanghai, China. The prescription rates and proportions of different statin types and doses among all patients were examined. Sub-analyses were performed when stratifying the patients by age, gender, dose intensity, and preventative intervention.


RESULTS
During the study period, a total of 51,083 patients, who were prescribed for statins, were included in this study (mean [SD] age, 59.78 [±13.16] years; 53.60% male, n = 27, 378). The overall statins prescription rate in which patients increased from 2012 (1.24, 95% CI: 1.21-1.27%) to 2018 (3.16, 95% CI: 3.11-3.20%), P < 0.001. Over 90% of patients were given a moderate dose of statins. Patients with a history of coronary and cerebrovascular events (over 32%) were more likely to be prescribed with statins for preventative intervention. Furthermore, our study has witnessed a significant rise in statin therapy in primary and secondary prevention.


CONCLUSIONS
In conclusion, statins were frequently prescribed and steadily increased over time in our study period. There were also changes in statin drug choices and dosages. A coordinated effort among the patient, clinical pharmacist, stakeholders and health system is still needed to improve statin utilization in clinical practice in the future.
['Liu|Yujuan|Y|0000-0002-1172-4886', 'Lv|Xiaoqun|X|', 'Xie|Ning|N|', 'Fang|Zhonghong|Z|', 'Ren|Weifang|W|', 'Gong|Yuan|Y|', 'Jin|Yan|Y|', 'Zhang|Jun|J|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D015415:Biomarkers D002318:Cardiovascular Diseases D002681:China D003430:Cross-Sectional Studies D011307:Drug Prescriptions D004363:Drug Utilization D050171:Dyslipidemias D005260:Female D006751:Hospital Information Systems D006801:Humans D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors D008055:Lipids D008297:Male D008875:Middle Aged D010607:Pharmacy Service, Hospital D010818:Practice Patterns, Physicians' D011322:Primary Prevention D055502:Secondary Prevention D013997:Time Factors D016896:Treatment Outcome D055815:Young Adult
Statins Prevalence Initiation Cardiovascular disease Preventative intervention