Exposure to chlorinated solvents and lung cancer: results of the ICARE study.
OBJECTIVE
To investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology.


METHODS
ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers) is a French, multicentre, population-based, case-control study. Information on the lifelong work history of 2926 cases and 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents. Solvents were studied separately and in combinations. ORs were computed using unconditional logistic regression models adjusted for classic risk factors, including a history of cigarette smoking and exposure to asbestos. Adjustment for socioeconomic status (SES) was also made.


RESULTS
After adjustment for exposure to asbestos, we observed a positive, statistically significant association with lung cancer for men and women exposed to a combination of perchloroethylene (PCE), trichloroethylene and dichloromethane (DCM). Further adjustment for SES slightly decreased this association. In contrast, no statistically significant associations were found for other solvent combinations.


CONCLUSIONS
These results suggest that exposure to PCE may constitute a risk factor for lung cancer, especially among women, who seem to have a higher prevalence of exposure than men.
['Mattei|Francesca|F|', 'Guida|Florence|F|', 'Matrat|Mireille|M|', 'Cenée|Sylvie|S|', 'Cyr|Diane|D|', 'Sanchez|Marie|M|', 'Radoi|Loredana|L|', 'Menvielle|Gwenn|G|', 'Jellouli|Fatima|F|', 'Carton|Matthieu|M|', 'Bara|Simona|S|', 'Marrer|Emilie|E|', 'Luce|Danièle|D|', 'Stücker|Isabelle|I|']
D000368:Aged D002273:Carcinogens D016022:Case-Control Studies D005260:Female D005602:France D006801:Humans D016015:Logistic Models D008175:Lung Neoplasms D008297:Male D008752:Methylene Chloride D008875:Middle Aged D016273:Occupational Exposure D016017:Odds Ratio D012307:Risk Factors D012737:Sex Factors D012997:Solvents D013750:Tetrachloroethylene D014241:Trichloroethylene
Chlorinated Solvents Lung Cancer Occupational Exposure Case-Control Study