Prognostic role of baseline 18F-FDG PET/CT metabolic parameters in Burkitt lymphoma.
PURPOSE
Burkitt's lymphoma (BL) is an aggressive lymphoma subtype with high 18F-FDG avidity at 18F-FDG-PET/CT, but no validated criteria for PET/CT in treatment evaluation or prediction of outcome in BL are available. The aim of our study was to investigate whether the metabolic baseline PET/CT parameters can predict treatment response and prognosis in BL.


MATERIALS AND METHODS
We retrospectively enrolled 65 patients who underwent baseline 18F-FDG-PET/CT, interim and end of treatment PET/CT. The PET images were analyzed visually and semi-quantitatively by measuring the maximum standardized uptake value body weight (SUVbw), the maximum standardized uptake value lean body mass (SUVlbm), the maximum standardized uptake value body surface area (SUVbsa), lesion to liver SUVmax ratio (L-L SUV R), lesion to blood-pool SUVmax ratio (L-BP SUV R), total metabolic tumor volume (tMTV) and total lesion glycolysis (TLG). Survival curves were plotted according to the Kaplan-Meier method.


RESULTS
At a median follow-up of 40 months, the median PFS and OS were 34 and 39 months. MTV and TLG were significantly higher in patients with partial response compared to complete response group at end of treatment, while no significant differences were found at interim. Other metabolic PET/CT parameters were not related to treatment response. MTV and TLG were demonstrated to be independent prognostic factors for both PFS and OS; instead SUVbw, SUVlbm, SUVbsa, L-L SUV R and L-BP SUV R were not related to outcome survival.


CONCLUSIONS
Metabolic tumour features (MTV and TLG) were significantly correlated with response to treatment and long-term outcome.
['Albano|Domenico|D|http://orcid.org/0000-0003-0810-6494', 'Bosio|Giovanni|G|', 'Pagani|Chiara|C|', 'Re|Alessandro|A|', 'Tucci|Alessandra|A|', 'Giubbini|Raffaele|R|', 'Bertagna|Francesco|F|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D002051:Burkitt Lymphoma D005260:Female D019788:Fluorodeoxyglucose F18 D006019:Glycolysis D006801:Humans D008297:Male D008875:Middle Aged D000072078:Positron Emission Tomography Computed Tomography D011237:Predictive Value of Tests D011379:Prognosis D019275:Radiopharmaceuticals
18F-FDG PET/CT Burkitt lymphoma Prognosis TLG MTV