Correlation between the expression of Id-1 and hyperthermia-associated molecules in oral squamous cell carcinoma.
OBJECTIVE
To investigate the expression of inhibitor of differentiation/DNA binding (Id-1), phosphatidylinositol-3-kinase/protein kinase B pathway proteins and hyperthermia-associated protein and their association with various clinicopathological factors in oral squamous cell cancer (OSCC), and explore the relationship among them in OSCC.


METHODS
Id-1, phosphorylated protein kinase B (p-Akt), phosphorylated glycogen synthase kinase 3β (p-GSK3β) and phosphorylated heat shock factor 1 (p-HSF1) expression were assessed immunohistochemically in 76 OSCC.


RESULTS
Id-1 (73.8%), p-Akt (65.8%), p-GSK3β (60.5%) and p-HSF1 (75%) were found to be overexpressed in most of the oral cancer samples tested, and the expressions of them are correlated with advanced clinical stage, metastasis and recurrence (p<0.01), but there is no apparent relationship with gender, age, differentiation and habits (p>0.05). Survival curves show that the survival of patients with high Id-1, p-Akt, p-GSK3β and p-HSF1 expression was significantly worse than those with low Id-1, p-Akt, p-GSK3β and p-HSF1 expression (p=0.000). Id-1 expression was significantly higher in cases with high expression of p-Akt, p-GSK3β and p-HSF1 than in those with low expression (p=0.002, p=0.003, p=0.001).


CONCLUSIONS
This study revealed that there was a positive correlation between Id-1 expression and the expression of p-Akt, p-GSK3β and p-HSF1. The inhibition of Id-1 expression can improve the efficacy of hyperthermia in OSCC.
['Zhao|Jun|J|', 'Wang|Shengzhi|S|', 'Liu|Na|N|', 'Tang|Xiufa|X|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D002294:Carcinoma, Squamous Cell D002454:Cell Differentiation D004268:DNA-Binding Proteins D005260:Female D038362:Glycogen Synthase Kinase 3 D000076249:Heat Shock Transcription Factors D006801:Humans D051798:Inhibitor of Differentiation Protein 1 D008297:Male D008875:Middle Aged D009062:Mouth Neoplasms D019869:Phosphatidylinositol 3-Kinases D010766:Phosphorylation D051057:Proto-Oncogene Proteins c-akt D015398:Signal Transduction D014157:Transcription Factors
Id-1 inhibitor of differentiation/DNA binding Cancer cancer research head and neck cancer immunohistochemistry phosphorylated Akt phosphorylated GSK3β phosphorylated HSF1