Iso-osmolar contrast media and adverse renal and cardiac events after percutaneous cardiovascular intervention.
AIM
To assess the relationship between type of contrast media (CM), iso-osmolar contrast media (IOCM) or low-osmolar contrast media (LOCM), and major adverse renal and cardiovascular events (MARCE).


MATERIALS & METHODS
Coronary or peripheral angioplasty visits were stratified into CM cohorts: IOCM or LOCM. Multivariable regression analysis used hospital fixed effects to assess the relationship between MARCE events and type of CM.


RESULTS
Among 333,533 visits (357 hospitals), the incidence of MARCE was 7.41%. After controlling for observable and unobservable time invariant within-hospital characteristics, administration of IOCM versus LOCM was associated with a 0.69% absolute and 9.32% relative risk reduction in MARCE rate.


CONCLUSION
Our study indicates that as compared with LOCM, IOCM may be associated with reduction of MARCE events in coronary or peripheral angioplasty patients.
['McCullough|Peter A|PA|', 'David|Guy|G|', 'Todoran|Thomas M|TM|', 'Brilakis|Emmanouil S|ES|', 'Ryan|Michael P|MP|', 'Gunnarsson|Candace|C|']
D000328:Adult D000368:Aged D002319:Cardiovascular System D015897:Comorbidity D003287:Contrast Media D016208:Databases, Factual D005260:Female D006801:Humans D015994:Incidence D007668:Kidney D008297:Male D008875:Middle Aged D015233:Models, Statistical D009994:Osmolar Concentration D012306:Risk D014283:Triiodobenzoic Acids
low-osmolar contrast media major adverse renal and cardiovascular events (MARCE) angioplasty relative risk