The role of IL-17 in vitiligo: A review.
IL-17 is involved in the pathogenesis of several autoimmune diseases; however its role in vitiligo has not been well defined. Emerging human and mouse studies have demonstrated that systemic, tissue, and cellular levels of IL-17 are elevated in vitiligo. Many studies have also shown significant positive correlations between these levels and disease activity, extent, and severity. Treatments that improve vitiligo, such as ultraviolet B phototherapy, also modulate IL-17 levels. This review synthesizes our current understanding of how IL-17 may influence the pathogenesis of autoimmune vitiligo at the molecular level. This has implications for defining new vitiligo biomarkers and treatments.
['Singh|Rasnik K|RK|', 'Lee|Kristina M|KM|', 'Vujkovic-Cvijin|Ivan|I|', 'Ucmak|Derya|D|', 'Farahnik|Benjamin|B|', 'Abrouk|Michael|M|', 'Nakamura|Mio|M|', 'Zhu|Tian Hao|TH|', 'Bhutani|Tina|T|', 'Wei|Maria|M|', 'Liao|Wilson|W|']
D000818:Animals D001327:Autoimmune Diseases D006801:Humans D020381:Interleukin-17 D008544:Melanocytes D058504:Th17 Cells D014467:Ultraviolet Therapy D014820:Vitiligo
IL-17 Vitiligo Interleukin-17