Spectroscopic and computational insights into theophylline/β-cyclodextrin complexation: inclusion accomplished by diverse methods.
Current scenario in asthmatic prevalence worldwide calls for a facile, cost-effective, and energy efficient methodology to formulate the potent bronchodilator, theophylline (THP), into an effective dosage forms. Since the uses of THP are severely impeded by its poor aqueous solubility and low bioavailability, solid inclusion complexes (ICs) of THP in β-cyclodextrin (β-CD) were prepared to overcome the limitations. The ICs were developed by conventional methods and also by microwave irradiation method, which is environmentally more benign and requires lesser reaction time. The complexation phenomenon was effectual by the co-precipitation, freeze-drying, and microwave methods as affirmed from various spectroscopic analyses. 1H NMR and molecular docking studies illustrated the total inclusion of THP into β-CD cavity. Better efficacy of the microwaved product was witnessed in terms of drug content, dissolution, and anti-biofilm activities. Thus microwave irradiation can be utilised as a naive and economical methodology to design β-CD-THP dosage formulations.
['Das|Subhraseema|S|', 'Maharana|Jitendra|J|', 'Mohanty|Subhrajit|S|', 'Subuddhi|Usharani|U|']
D001993:Bronchodilator Agents D011232:Chemical Precipitation D004337:Drug Carriers D005612:Freeze Drying D008872:Microwaves D062105:Molecular Docking Simulation D012995:Solubility D013050:Spectrometry, Fluorescence D013056:Spectrophotometry, Ultraviolet D017550:Spectroscopy, Fourier Transform Infrared D013806:Theophylline D013816:Thermodynamics D014961:X-Ray Diffraction D047392:beta-Cyclodextrins
Theophylline β-cyclodextrin solid inclusion complexes microwave irradiation dissolution