Micafungin alone and in combination therapy with deferasirox against Pythium insidiosum.
This study evaluated the in vitro and in vivo activity of micafungin alone and in combination with the iron chelator deferasirox against Pythium insidiosum. Micafungin showed a poor in vitro activity when it was used alone, but synergistic interactions were observed for 88.2% of the strains when the drug was combined with deferasirox. Smaller lesions were observed in infected rabbits receiving the combination therapy, although it favored disease dissemination to the lungs. The present results show that micafungin alone is ineffective against P. insidiosum, and the combination micafungin-deferasirox might have deleterious effects for the host.
['Zanette|R A|RA|', 'Jesus|F P K|FP|', 'Pilotto|M B|MB|', 'Weiblen|C|C|', 'Pötter|L|L|', 'Ferreiro|L|L|', 'Alves|S H|SH|', 'Santurio|J M|JM|']
D000818:Animals D000935:Antifungal Agents D001565:Benzoates D000077588:Deferasirox D004195:Disease Models, Animal D004359:Drug Therapy, Combination D054714:Echinocandins D005260:Female D006734:Horse Diseases D006736:Horses D055666:Lipopeptides D000077551:Micafungin D008826:Microbial Sensitivity Tests D058968:Pythiosis D011775:Pythium D011817:Rabbits D014230:Triazoles
Iron chelator Chélateur du fer Echinocandin Oomycete Oomycète Sensibilité Susceptibility Échinocandine