Association between metabolic syndrome and functional outcome in patients with acute ischaemic stroke.
BACKGROUND AND PURPOSE
There is a paucity of information on the role of metabolic syndrome (MetS) as a prognosticator after ischaemic stroke. We investigated the association between MetS and functional outcome in patients with acute ischaemic stroke.


METHODS
We evaluated 691 consecutive patients with acute stroke who were admitted to a tertiary medical center between January 2007 and June 2011. We defined MetS as having three or more of the five cardinal cardiovascular risk factors. Unfavorable functional outcome was determined using responder analysis, in which the outcome was adjusted by the initial severity of the stroke. Multivariable logistic regression analysis was used to evaluate the relationship between MetS and unfavorable outcomes (UnFO).


RESULTS
Among 691 patients, 277 patients were classified as having an UnFO. The association between MetS and UnFO remained significant after adjusting for possible confounders; the adjusted odds ratio (95% confidence interval) was 1.57 (1.13-2.19). The risk for UnFO was positively associated with the number of MetS components.


CONCLUSIONS
MetS may be a potent predictor of functional outcome after ischaemic stroke.
['Oh|M Y|MY|', 'Ko|S B|SB|', 'Lee|S H|SH|', 'Kim|C|C|', 'Ryu|W S|WS|', 'Kim|C H|CH|', 'Yoon|B W|BW|']
D000368:Aged D005260:Female D006801:Humans D008297:Male D024821:Metabolic Syndrome D016017:Odds Ratio D020127:Recovery of Function D012307:Risk Factors D020521:Stroke
metabolic syndrome stroke