GFRα2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer.
Nerve growth factors and their receptors have received an increasing attention in certain cancers since they play an important role in regulating tumorigenesis, biological process and metastasis. Here we aimed at characterizing a new function of one of the subtypes of growth factor receptors (GFR), GFRα2, in pancreatic cancer. In this study, we showed that GFRα2 was up-regulated in pancreatic adenocarcinoma and was positively correlated with tumor size and perineural invasion, which indicated that it may be associated with cell growth and apoptosis. Mechanically, we discovered that high GFRα2 expression level leads to PTEN inactivation via enhancing Mir-17-5p level.
['Gu|Jiangning|J|', 'Wang|Di|D|', 'Zhang|Jiaqiang|J|', 'Zhu|Yi|Y|', 'Li|Ying|Y|', 'Chen|Hao|H|', 'Shi|Minmin|M|', 'Wang|Xuelong|X|', 'Shen|Baiyong|B|', 'Deng|Xiaxing|X|', 'Zhan|Qian|Q|', 'Wei|Gang|G|', 'Peng|Chenghong|C|']
D000818:Animals D021441:Carcinoma, Pancreatic Ductal D045744:Cell Line, Tumor D049109:Cell Proliferation D003841:Deoxycytidine D019008:Drug Resistance, Neoplasm D005260:Female D015971:Gene Expression Regulation, Enzymologic D015972:Gene Expression Regulation, Neoplastic D051097:Glial Cell Line-Derived Neurotrophic Factor Receptors D006801:Humans D053208:Kaplan-Meier Estimate D008297:Male D008819:Mice, Nude D035683:MicroRNAs D009361:Neoplasm Invasiveness D051059:PTEN Phosphohydrolase D010190:Pancreatic Neoplasms D034622:RNA Interference D015398:Signal Transduction D013997:Time Factors D014162:Transfection D047368:Tumor Burden
GFRα2 Chemoresistance PTEN Mir-17-5p Pancreatic cancer