Treatment of atrophic acne scars using autologous platelet-rich plasma vs combined subcision and autologous platelet-rich plasma: A split-face comparative study.
BACKGROUND
Multiple therapeutic approaches are usually required when treating atrophic acne scars. Subcision was reported to be of value in improving rolling scars. Autologous platelet-rich plasma (PRP) has recently been proposed as an adjuvant treatment option for atrophic acne scars with few reports evaluating its efficacy.


OBJECTIVE
Our objective was to compare the effect of intradermal injection of PRP vs combined PRP and subcision in the treatment of atrophic acne scars.


METHODS
Thirty patients with bilateral atrophic acne scars were enrolled. Each patient received three monthly sessions. Each side of the face was randomly treated either with intradermal PRP alone or with combined treatment with subcision followed by PRP injection. Patients were assessed at 3 and 6 months following the last treatment session. Evaluation of serial photographs was performed by two blinded investigators.


RESULTS
Platelet-rich plasma alone showed a better response, fewer side effects, and shorter downtime compared to combined subcision and PRP.


CONCLUSION
Autologous PRP injection can be a therapeutic option in the treatment of atrophic acne scars, with fewer complications and better tolerability than combined subcision and autologous PRP.
['Hassan|Akmal Saad|AS|https://orcid.org/0000-0001-6880-7474', 'El-Hawary|Marwa Safwat|MS|', 'Abdel Raheem|Heba Mohammed|HM|https://orcid.org/0000-0001-5564-9366', 'Abdallah|Samar Hassan|SH|', 'El-Komy|Mohamed Medhat|MM|']
D000152:Acne Vulgaris D000293:Adolescent D000328:Adult D001284:Atrophy D001804:Blood Transfusion, Autologous D002921:Cicatrix D003131:Combined Modality Therapy D003357:Cosmetic Techniques D005260:Female D005500:Follow-Up Studies D006801:Humans D007271:Injections, Intradermal D008297:Male D009339:Needles D017060:Patient Satisfaction D053657:Platelet-Rich Plasma D016896:Treatment Outcome D055815:Young Adult
atrophic acne scars platelet-rich plasma subcision