Long-term management of a cat with nasopharyngeal lymphoma by chlorambucil.
Background
Lymphoma in the nasal cavity is the most common tumor of cats' upper respiratory tract. However, the effect of single-agent chlorambucil on nasal or nasopharyngeal lymphoma has not been evaluated in cats.


Case Description
An 8-year-old, castrated male Scottish Fold weighing 3.5 kg presented with an 8-month history of nasal discharge, sneezing, and mild epistaxis. CT and rhinoscopy revealed nasal discharge and slight swelling of the nasopharyngeal mucosa, but no masses and local invasions were detected. Histopathological and immunohistochemical analyses of the nasopharyngeal mucosa demonstrated B-cell lymphoma in the cat. The treatment with chlorambucil led to long-term management of the cat without any side effects. No recurrences of clinical signs have been observed for 754 days.


Conclusion
The present case report suggests that chlorambucil can be a therapeutic option for feline localized nasopharyngeal B-cell lymphoma without masses and local invasions.
['Takahashi|Kaho|K|', 'Baba|Takashi|T|', 'Hirokawa|Marin|M|', 'Miyajima|Masaki|M|', 'Kishimoto|Miori|M|', 'Kimura|Junpei|J|', 'Kondo|Hirotaka|H|', 'Ohmori|Keitaro|K|']
D000818:Animals D002415:Cats D002699:Chlorambucil D008223:Lymphoma D008297:Male D009296:Nasal Cavity D009305:Nasopharynx D009364:Neoplasm Recurrence, Local
Cat Lymphoma Chlorambucil Nasal cavity Nasopharynx