Numerical investigation of thermal response of laser-irradiated biological tissue phantoms embedded with gold nanoshells.
The work presented in this paper focuses on numerically investigating the thermal response of gold nanoshells-embedded biological tissue phantoms with potential applications into photo-thermal therapy wherein the interest is in destroying the cancerous cells with minimum damage to the surrounding healthy cells. The tissue phantom has been irradiated with a pico-second laser. Radiative transfer equation (RTE) has been employed to model the light-tissue interaction using discrete ordinate method (DOM). For determining the temperature distribution inside the tissue phantom, the RTE has been solved in combination with a generalized non-Fourier heat conduction model namely the dual phase lag bio-heat transfer model. The numerical code comprising the coupled RTE-bio-heat transfer equation, developed as a part of the current work, has been benchmarked against the experimental as well as the numerical results available in the literature. It has been demonstrated that the temperature of the optical inhomogeneity inside the biological tissue phantom embedded with gold nanoshells is relatively higher than that of the baseline case (no nanoshells) for the same laser power and operation time. The study clearly underlines the impact of nanoshell concentration and its size on the thermal response of the biological tissue sample. The comparative study concerned with the size and concentration of nanoshells showed that 60nm nanoshells with concentration of 5×1015mm-3 result into the temperature levels that are optimum for the irreversible destruction of cancer infected cells in the context of photo-thermal therapy. To the best of the knowledge of the authors, the present study is one of the first attempts to quantify the influence of gold nanoshells on the temperature distributions inside the biological tissue phantoms upon laser irradiation using the dual phase lag heat conduction model.
['Phadnis|Akshay|A|', 'Kumar|Sumit|S|', 'Srivastava|Atul|A|']
D000465:Algorithms D003198:Computer Simulation D003287:Contrast Media D006046:Gold D006358:Hot Temperature D006801:Humans D006979:Hyperthermia, Induced D053685:Laser Therapy D007834:Lasers D008954:Models, Biological D057145:Nanoshells D009369:Neoplasms D010789:Phototherapy D013814:Thermal Conductivity
Gold nanoshells Photo-thermal therapy Radiative transfer equation Non-Fourier heat conduction Bio-heat transfer Optical inhomogeneity