Identification of the Risk Factors for Recurrence of Stage III Colorectal Cancer.
BACKGROUND/AIM
This study aimed to identify risk factors for recurrence of patients with stage III colorectal cancer by assessing clinicopathological features.


PATIENTS AND METHODS
The study included 231 patients with stage III colorectal cancer who underwent curative resection between 2006 and 2012 at the Department of Surgery of the Jikei University Hospital, Tokyo, Japan. Clinicopathological data of the patients were retrospectively evaluated.


RESULTS
The recurrence rate was 27.7% (64/231) in the study group. The univariate analysis for recurrence identified five risk factors: site of primary tumor (rectal cancer), surgical procedure (open surgery), preoperative serum CEA level (>5 ng/ml), preoperative serum CA19-9 level (>37 U/ml), and number of metastatic lymph nodes (over three metastases). The multivariate analysis for recurrence identified three risk factors: rectal cancer, preoperative serum CEA level >5.0 ng/ml 95%, and more than three metastatic lymph nodes.


CONCLUSION
The risk factors for stage III colorectal cancer recurrence seem to be rectal cancer, preoperative serum CEA level >5.0 ng/ml, and more than three metastatic lymph nodes.
['Neki|Kai|K|', 'Eto|Ken|K|', 'Kosuge|Makoto|M|', 'Ohkuma|Masahisa|M|', 'Ito|Daisuke|D|', 'Takeda|Yasuhiro|Y|', 'Yatabe|Saori|S|', 'Sugano|Hiroshi|H|', 'Yanaga|Katsuhiko|K|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D014408:Biomarkers, Tumor D018395:CA-19-9 Antigen D002272:Carcinoembryonic Antigen D015179:Colorectal Neoplasms D005260:Female D006801:Humans D007564:Japan D008198:Lymph Nodes D008207:Lymphatic Metastasis D008297:Male D009364:Neoplasm Recurrence, Local D009367:Neoplasm Staging D011379:Prognosis D012189:Retrospective Studies D012307:Risk Factors
Risk factors stage III colorectal cancer