Thermal Magnetic Field Activated Propolis Release From Liquid Crystalline System Based on Magnetic Nanoparticles.
Intra-periodontal pocket drug delivery systems, such as liquid crystalline systems, are widely utilized improving the drug release control and the therapy. Propolis is used in the treatment of periodontal diseases, reducing the inflammatory and infectious conditions. Iron oxide magnetic nanoparticles (MNPs) can improve the treatment when an alternating external magnetic field (AEMF) is applied, increasing the local temperature. The aim of this study was to develop a liquid crystalline system containing MNPs for intra-periodontal pocket propolis release. MNPs were prepared using iron salts and the morphological, size, thermal, x-ray diffraction, magnetometry, and Mössbauer spectroscopy analyses were performed. Cytotoxicity studies using Artemia salina and fibroblasts were also accomplished. The systems were prepared using polyoxyethylene (10) oleyl ether, isopropyl myristate, purified water, and characterized by polarized optical microscopy, rheometry, and in vitro drug release profile using a periodontal pocket simulator apparatus. The antifungal activity of the systems was investigated against Candida spp. using an AEMF. MNPs displayed nanometric size, were monodisperse, and they displayed very low cytotoxicity. Microscopically homogeneous formulations were obtained displaying important physicochemical and biological properties. The system displayed prolonged release of propolis and important in vitro fungicide activity, which was increased when the AEMF was applied, indicating a potentially alternative therapy for the treatment of the periodontal disease.
['de Alcântara Sica de Toledo|Lucas|L|', 'Rosseto|Hélen Cássia|HC|', 'Dos Santos|Rafaela Said|RS|', 'Spizzo|Federico|F|', 'Del Bianco|Lucia|L|', 'Montanha|Maiara Camotti|MC|', 'Esposito|Elisabetta|E|', 'Kimura|Elza|E|', 'Bonfim-Mendonça|Patricia de Souza|PS|', 'Svidzinski|Terezinha Inez Estivalet|TIE|', 'Cortesi|Rita|R|', 'Bruschi|Marcos Luciano|ML|']
D000818:Animals D000935:Antifungal Agents D001156:Artemia D016503:Drug Delivery Systems D065546:Drug Liberation D005347:Fibroblasts D050866:Liquid Crystals D060526:Magnetic Fields D058185:Magnetite Nanoparticles D011429:Propolis D013696:Temperature D014961:X-Ray Diffraction
magnetic nanoparticles drug delivery periodontal disease buccal natural products