The impact of antecedent primary malignancy in soft tissue sarcoma patients.
BACKGROUND
It is unclear whether antecedent primary malignancies (APMs) have any negative impact on the prognosis of soft tissue sarcoma (STS). We retrospectively reviewed STS patients with APMs (STS-APM) and compared their survival to those of STS only (STS-O).


METHODS
Twenty-one cases of STS-APM from 2008 to 2017 in our institution were analyzed. One hundred and seventy cases of STS-O at the same period were compared as a control group. Overall survival was estimated using Kaplan-Meier survival curves and prognostic factors were analyzed using logistic regression analyses and contingency table analyses.


RESULTS
As the final status of STS-APM patients, 12 patients were in disease-free survival, 5 were alive with disease, 3 have died of disease, and 1 has died of another disease. There was no case that died of APM. The 5-year overall survival rates were 88% in STS-APM and 78% in STS-O, showing no statistical significant ( p = 0.65). The 5-year overall survival rates in each stage of STS-APM and STS-O were 100/100% in stage I, 100/85% in stage II, 86/72% in stage III, and the 3-year overall survival rates were 67/51% in stage IV, with no statistical significance. With regard to prognostic factor, histological grade of STS was the only significant factor. Although antecedent radiotherapy tended to show a high odds ratio, the association was not statistically significant. Antecedent chemotherapy did not show any estimated prognostic risk.


CONCLUSIONS
Our study suggested that APM in STS patient would not be a negative prognostic factor.
['Torigoe|Tomoaki|T|', 'Imanishi|Jungo|J|', 'Yazawa|Yasuo|Y|', 'Kadono|Yuho|Y|', 'Oda|Hiromi|H|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D018572:Disease-Free Survival D005260:Female D006801:Humans D053208:Kaplan-Meier Estimate D008297:Male D008875:Middle Aged D011379:Prognosis D012189:Retrospective Studies D012509:Sarcoma D012983:Soft Tissue Neoplasms D015996:Survival Rate D055815:Young Adult
antecedent primary malignancy soft tissue sarcoma prognosis multiple primary malignancy