In Vitro and In Vivo Evaluations of Mesoporous Iron Particles for Iron Bioavailability.
Chronic renal failure involving hemodialysis results in blood loss during filtration. Iron deficiency and iron deficiency anemia can result. A compensatory increase in iron dosage has many side effects including discomfort. Elemental iron is a highly-pure iron source, which reduces the frequency of dosages; the solubility decreases with increased particle size or pore size. In this study, synthesized mesoporous iron particles (MIPs) were used to relieve iron deficiency anemia. Their bioavailability was measured in vitro by a Caco-2 cell model and in vivo in iron-deficient rats. In vitro bioavailability of MIPs was examined by measuring ferritin content in the Caco-2 cell model. Iron uptake of MIPs was significantly higher than commercial iron particles, which were less porous. In vivo bioavailability of MIPs was examined by measuring body weight gain and red blood cell-related parameters, compared with the bioavailability of standard drug ferrous sulfate in iron-deficient anemic rats. Finally, average hemoglobin content and hemoglobin regeneration efficiency were significantly higher in anemic rats supplemented with commercial iron particles, compared to anemic controls. In the 28-day oral toxicity test, MIPs were not significantly toxic to rat physiology or tissue histopathology. Thus, MIPs may allow effective recovery of hemoglobin in iron deficiency anemia.
['Lin|Jung-Feng|JF|', 'Wu|Chau-Chung|CC|', 'Liao|Yu-Jiun|YJ|', 'Jakfar|Subhaini|S|', 'Tang|Zi-Biao|ZB|', 'Chen|Jhewn-Kuang|JK|', 'Lin|Feng-Huei|FH|']
D000284:Administration, Oral D018798:Anemia, Iron-Deficiency D000818:Animals D001672:Biocompatible Materials D001835:Body Weight D018938:Caco-2 Cells D002470:Cell Survival D004195:Disease Models, Animal D005293:Ferritins D005296:Ferrous Compounds D006454:Hemoglobins D006801:Humans D007501:Iron D008297:Male D053758:Nanoparticles D010316:Particle Size D016062:Porosity D051381:Rats D017208:Rats, Wistar D062826:Zonula Occludens-1 Protein
mesoporous iron particle hemodialysis iron deficiency anemia hemoglobin