Tissue distribution and elimination features of florfenicol in hybrid sturgeon cultured in cool water.
In order to understand pharmacokinetics in vivo and tissue residues of florfenicol in Hybrid sturgeon cultured in cold water, changes in concentration of florfenicol in plasma, muscle, liver and kidney of sturgeon after administration were measured by high performance liquid chromatography mass spectrometry. The results show that after 15.0 mg/kg dose administration, the concentration change in plasma and liver, kidney and muscle of sturgeon are suitable for the one compartment open model. Florfenicol pharmacokinetic parameters in plasma, liver, kidney and sturgeon muscle showed that the peak concentration (Cmax ) were 549.7, 551.8, 958.2 and 405.4 μg/kg, respectively. The peak time (Tmax ) was 17.5, 14.2, 14.0 and 20.8 hr, respectively. The elimination half-life (T1/2 ) was 75.1, 99.8, 68.8 and 75.5 hr, respectively. Area under the curve were 70,048.9, 63,850.6, 109,579.9 and 53,437.3 μg/kg hr, respectively. Mean residence time was 100.6, 96.4, 96.5 and 104.6 hr, respectively. The absorption speed and elimination of florfenicol in cold water cultured sturgeon is slow, and the peak concentration is low, but the florfenicol was widely distributed in the body of sturgeon. The results provide a theoretical basis for formulation of medication and withdrawal period of florfenicol used in sturgeon cultured in cold water.
['Yang|Yuanhao|Y|', 'Yang|Juanning|J|', 'Shang|Derong|D|', 'Li|Fengling|F|http://orcid.org/0000-0001-9530-2068', 'Wang|Lvzhou|L|', 'Li|Fenggang|F|', 'Li|Yi|Y|', 'Sun|Yuhang|Y|', 'He|Shuangheng|S|', 'Wu|Jinxing|J|']
D000818:Animals D000900:Anti-Bacterial Agents D019540:Area Under Curve D003080:Cold Temperature D005399:Fishes D006207:Half-Life D006824:Hybridization, Genetic D007668:Kidney D008099:Liver D018482:Muscle, Skeletal D015203:Reproducibility of Results D013839:Thiamphenicol
florfenicol sturgeon pharmacokinetics residues HPLC-MS