Extraprostatic Uptake of 18F-Fluciclovine: Differentiation of Nonprostatic Neoplasms From Metastatic Prostate Cancer.
OBJECTIVE. Fluciclovine is a synthetic radiolabeled amino acid analog used for imaging of biochemical recurrent prostate cancer. Uptake of fluciclovine is mediated by several amino acid transporters, including alanine-serine-cysteine transporter 2 and large neutral amino acid transporters, which are known to be overexpressed in other malignancies. CONCLUSION. Knowledge of the common patterns of prostate cancer recurrence, in addition to what other neoplasms can show uptake, is critical for accurate study interpretation.
['Robertson|Matthew S|MS|', 'Sakellis|Christopher G|CG|', 'Hyun|Hyewon|H|', 'Jacene|Heather A|HA|']
D002264:Carboxylic Acids D003503:Cyclobutanes D003937:Diagnosis, Differential D006801:Humans D008297:Male D009362:Neoplasm Metastasis D009364:Neoplasm Recurrence, Local D000072078:Positron Emission Tomography Computed Tomography D011471:Prostatic Neoplasms D019275:Radiopharmaceuticals
fluciclovine amino acid transporter Axumin PET/CT molecular imaging