Vitamin C Deficiency-Induced Pulmonary Arterial Hypertension.
We report a case of a man in his 60s who developed pulmonary arterial hypertension (PAH) in association with profound vitamin C deficiency. Decreased availability of endothelial nitric oxide and activation of the hypoxia-inducible family of transcription factors, both consequences of vitamin C deficiency, are believed to be mechanisms contributing to the pathogenesis of the pulmonary hypertension. The PAH resolved following vitamin C supplementation. The current case highlights the importance of testing for vitamin C deficiency in patients with PAH in the proper clinical setting.
['Gayen|Shameek K|SK|', 'Abdelrahman|Abd A|AA|', 'Preston|Ioana R|IR|', 'Petit|Raymond D|RD|', 'Hill|Nicholas S|NS|']
D000368:Aged D000740:Anemia D018771:Arthralgia D001205:Ascorbic Acid D001206:Ascorbic Acid Deficiency D006328:Cardiac Catheterization D004452:Echocardiography D004730:Endothelium, Vascular D005076:Exanthema D006801:Humans D000860:Hypoxia D008297:Male D009569:Nitric Oxide D000081029:Pulmonary Arterial Hypertension D014157:Transcription Factors D014815:Vitamins
pulmonary arterial hypertension case report respiratory failure