Bajijiasu Ameliorates β-Amyloid-Triggered Endoplasmic Reticulum Stress and Related Pathologies in an Alzheimer's Disease Model.
BACKGROUND/AIMS
Alzheimer disease (AD) is a common neurodegenerative disease that is characterized by the deposition of beta-amyloid peptide and formation of intracellular neurofibrillary tangles. Due to the failure of various clinical trials of novel drugs for AD, effective drugs for AD treatment are urgently required.


METHODS
In this study, we used the classic APP/PS1 mouse model to explore the neuroprotective effects of a new compound, bajijiasu, and the mechanisms involved. Behavioral tests and western blotting were performed to assess the beneficial effects of bajijiasu in APP/PS1 mice.


RESULTS
Morris water maze and Y-maze test results showed that oral administration of bajijiasu (35 mg/kg/day and 70 mg/kg/day) improved learning and memory abilities in APP/PS1 mice. Bajijiasu reduced ROS and MDA levels in both the hippocampus and cortex. Moreover, western blotting results showed that bajijiasu protected neurons from apoptosis, elevated the expression levels of neurotrophic factors, and alleviated endoplasmic reticulum stress in both the hippocampus and cortex.


CONCLUSION
These results indicate that the mechanisms underlying the effects of bajijiasu on AD might be related to beta-amyloid-downstream pathologies, particularly endoplasmic reticulum stress.
['Xu|Ting-Ting|TT|', 'Zhang|Yang|Y|', 'He|Jia-Yang|JY|', 'Luo|Dan|D|', 'Luo|Yi|Y|', 'Wang|Yi-Jie|YJ|', 'Liu|Wei|W|', 'Wu|Jun|J|', 'Zhao|Wei|W|', 'Fang|Jiansong|J|', 'Guan|Li|L|', 'Huang|Shun|S|', 'Wang|Hong|H|', 'Lin|Li|L|', 'Zhang|Shi-Jie|SJ|', 'Wang|Qi|Q|']
D000284:Administration, Oral D000544:Alzheimer Disease D016564:Amyloid beta-Protein Precursor D000818:Animals D053148:Caspase 3 D002525:Cerebellar Cortex D004187:Disaccharides D004195:Disease Models, Animal D059865:Endoplasmic Reticulum Stress D006624:Hippocampus D008297:Male D008315:Malondialdehyde D018782:Maze Learning D051379:Mice D008822:Mice, Transgenic D009414:Nerve Growth Factors D018696:Neuroprotective Agents D053764:Presenilin-1 D019253:Proto-Oncogene Proteins c-bcl-2 D017382:Reactive Oxygen Species D051028:bcl-2-Associated X Protein
Bajijiasu Alzheimer Disease Aβ ER Stress