Hypertension, Left Ventricular Hypertrophy, and Myocardial Ischemia.
The risks associated with hypertension emerge through a series of complex interactions. Myocardial ischemia is the major contributor to this risk. The mechanisms driving ischemia reflect many of the key factors in hypertension, including endothelial and neurohumoral factors, fibrosis, and hemodynamics. Left ventricular hypertrophy and fibrosis are of fundamental importance and together with hemodynamics provide an optimal template for myocardial ischemia. Understanding the pathophysiology has aided a more rational management approach but challenges remain which, if surmounted, will have an impact on the morbidity and mortality caused by myocardial ischemia in patients with hypertension.
['Stanton|Tony|T|', 'Dunn|Francis G|FG|']
D000222:Adaptation, Physiological D000959:Antihypertensive Agents D003327:Coronary Disease D006801:Humans D006973:Hypertension D017379:Hypertrophy, Left Ventricular D017202:Myocardial Ischemia
Hypertension Ischemia Mechanisms Management Perfusion