Comparative Analysis of NF-κB in the MyD88-Mediated Pathway After Implantation of Titanium Alloy and Stainless Steel and the Role of Regulatory T Cells.
OBJECTIVE
Development of immunologically smart implants, integrated to biological systems, is a key aim to minimize the inflammatory response of the host to biomaterial implants.


METHODS
The aim of this study is to investigate the influence of titanium alloy and stainless steel implants on immunological responses in rats by comparative analysis of nuclear factor kappa B (NF-κB) profiles in the activation of inflammatory signaling pathways and the role of CD4+CD25+Foxp3+.


RESULTS
Both Ti alloy and stainless steel alloy group implantation affect Toll-like receptors-4 pathways and CD4+CD25+ regulatory T cells in different ways.


CONCLUSIONS
Results show that NF-κB/p65 and NF-κB1/p50 possess potential as a therapeutic target in the prevention of adverse reactions to metal, especially for controlling inflammation after the implantation.
['Akyol|Sibel|S|', 'Akgun|Mehmet Yigit|MY|', 'Yetmez|Mehmet|M|', 'Hanci|Murat|M|', 'Oktar|Faik Nuzhet|FN|', 'Ben-Nissan|Besim|B|']
D000497:Alloys D000818:Animals D015704:CD4 Antigens D051858:Forkhead Transcription Factors D007249:Inflammation D053645:Interleukin-2 Receptor alpha Subunit D008297:Male D053594:Myeloid Differentiation Factor 88 D016328:NF-kappa B D019736:Prostheses and Implants D051381:Rats D017208:Rats, Wistar D015398:Signal Transduction D013193:Stainless Steel D050378:T-Lymphocytes, Regulatory D014025:Titanium
Immunology Inflammatory signal Instrumentation Metal implant NF-κB profile Spinal surgery