Changes of Cerebral and/or Peripheral Adenosine A₁ Receptor and IGF-I Concentrations under Extended Sleep Duration in Rats.
Extended sleep improves sustained attention and reduces sleep pressure in humans. Downregulation of adenosine A₁ receptor (A₁R) and modulation of the neurotrophic factor insulin growth factor-1 (IGF-I) in brain structures controlling attentional capacities could be involved. In the frontal cortex and hippocampus of rats, we measured adenosine A₁R and IGF-I protein concentrations after photoperiod-induced sleep extension. Two groups of twelve rats were adapted over 14 days to a habitual (CON) 12:12 light-dark (LD) schedule and an extended (EXT) 16:8 LD schedule. IGF-I content was also measured in plasma, liver, and skeletal muscle. In EXT, compared to CON rats, A₁R content in the frontal cortex was significantly lower (p < 0.05), while IGF-I content was higher (p < 0.001), and no significant change was observed in the hippocampus. IGF-I content in plasma and muscle was higher (p < 0.001 and p < 0.01), while it was lower in liver (p < 0.001). The absolute weight and weight gain were higher in EXT rats (p < 0.01). These data suggest that 14 days under a 16:8 LD photoperiod respectively down- and upregulated cortical A₁R and IGF-I levels. This photoperiod induced an anabolic profile with increased weight gain and circulating and muscular IGF-I levels. An extension of sleep duration might favor cerebral and peripheral anabolism, which may help attentional and physical capacities.
['Chennaoui|Mounir|M|0000-0002-4409-813X', 'Arnal|Pierrick J|PJ|', 'Dorey|Rodolphe|R|', 'Sauvet|Fabien|F|0000-0002-4298-2319', 'Ciret|Sylvain|S|', 'Gallopin|Thierry|T|0000-0002-9741-3738', 'Leger|Damien|D|', 'Drogou|Catherine|C|', 'Gomez-Merino|Danielle|D|']
D000818:Animals D001835:Body Weight D005625:Frontal Lobe D006624:Hippocampus D006728:Hormones D006801:Humans D007334:Insulin-Like Growth Factor I D008099:Liver D008297:Male D018482:Muscle, Skeletal D017440:Photoperiod D051381:Rats D017208:Rats, Wistar D043682:Receptor, Adenosine A1 D012890:Sleep D013997:Time Factors D015430:Weight Gain
IGF-I sleep extension A1 receptor hormones peripheral and brain tissues