Evodiamine alleviates kidney ischemia reperfusion injury in rats: A biochemical and histopathological study.
Renal ischemia/reperfusion (I/R) injury resulting in acute renal failure, is a major clinical problem due to its high mortality rate. Renal I/R increases the reactive oxygen species, secretion of inflammatory cytokines, chemokines and other factors. This suggests that initiating the apoptosis process in the presence of oxidative stress may play a role in life-threatening conditions, such as ischemia. Ischemia reperfusion-induced renal damage can result in renal failure and death. Although many treatment procedures have been carried out to reduce or destroy renal I/R damage in experimental models, so far, a routine method of treatment has not yet been found. For this reason, the current study was planned to investigate the possible protective effects of evodiamine on tissue damage caused by ischemia-reperfusion in kidney tissue in rats and an experimental renal I/R model was used for this purpose. Four groups were formed in the study: the control, sham control, ischemia reperfusion (I/R), and evodiamine (10 mg/kg) + I/R groups. The effects of evodiamine against kidney I/R injury were investigated. TAS (total oxidant status), TOS (total oxidant status), interleukin-1β (IL-1β), IL-6, IL-10 and tumor necrosis factor-α levels were determined by enzyme-linked immunosorbent assay. The oxidative stress index was calculated from TAS and TOS levels. In addition, the renal ischemia reperfusion injury was examined histopathologically. The IL-10 and TAS levels in the I/R group decreased when compared with the control and Sham groups, while these levels increased in the evodiamine group. Histopathologic examination revealed that caspase 3 and nuclear factor-κB levels decreased in the evodiamine group compared with the I/R group. The application of evodiamine significantly reduced ischemia reperfusion-induced kidney damage due to its antioxidant, anti-inflammatory and antiapoptotic properties.
['Eraslan|Ersen|E|0000-0003-2424-2269', 'Tanyeli|Ayhan|A|', 'Polat|Elif|E|', 'Yetim|Zeliha|Z|']
D058186:Acute Kidney Injury D000818:Animals D000893:Anti-Inflammatory Agents D000975:Antioxidants D017209:Apoptosis D053148:Caspase 3 D005786:Gene Expression Regulation D007249:Inflammation D016753:Interleukin-10 D053583:Interleukin-1beta D015850:Interleukin-6 D007668:Kidney D008297:Male D016328:NF-kappa B D018384:Oxidative Stress D011799:Quinazolines D051381:Rats D017208:Rats, Wistar D017382:Reactive Oxygen Species D012077:Renal Artery D015427:Reperfusion Injury D013525:Surgical Instruments D016896:Treatment Outcome D014409:Tumor Necrosis Factor-alpha
evodiamine kidney ischemia reperfusion cytokines apoptosis oxidative stress nucler factor-κB