Profiles of psychosocial and clinical functioning in adolescence and risk for later depression and other outcomes.
BACKGROUND
Most studies examining predictors of the onset of depression focus on variable centered regression methods that focus on the effects of multiple predictors. In contrast, person-centered approaches develop profiles of factors and these profiles can be examined as predictors of onset. Here, we developed profiles of adolescent psychosocial and clinical functioning among adolescents without a history of major depression.


METHODS
Data come from a subsample of participants from the Oregon Adolescent Depression Project who completed self-report measures of functioning in adolescence and completed diagnostic and self-report measures at follow-up assessments up to approximately 15 years after baseline.


RESULTS
We identified four profiles of psychosocial and clinical functioning: Thriving; Average Functioning; Externalizing Vulnerability and Family Stress and Internalizing Vulnerability at the baseline assessment of participants without a history of depression at the initial assessment in mid-adolescence. Classes differed in the likelihood of onset and course of depressive disorders, experience of later anxiety and substance use disorders, and psychosocial functioning in adulthood. Moreover, the predictive utility of these classes was maintained when controlling for multiple other established risk factors for depressive disorders.


CONCLUSIONS
This work highlights the utility of examining multiple factors simultaneously to understand risk for depression.
['Olino|Thomas M|TM|0000-0001-5139-8571', 'Klein|Daniel N|DN|', 'Seeley|John R|JR|']
D000293:Adolescent D000294:Adolescent Behavior D000328:Adult D001008:Anxiety Disorders D003865:Depressive Disorder, Major D005260:Female D006801:Humans D000077272:Latent Class Analysis D008137:Longitudinal Studies D008297:Male D009922:Oregon D000083623:Psychosocial Functioning D018570:Risk Assessment D012307:Risk Factors D057566:Self Report D019966:Substance-Related Disorders D055815:Young Adult
psychosocial functioning Depression risk latent profiles