Spotlight on Accessory Proteins: RTK-RAS-MAPK Modulators as New Therapeutic Targets.
The RTK-RAS-MAPK axis is one of the most extensively studied signaling cascades and is related to the development of both cancers and RASopathies. In the last 30 years, many ideas and approaches have emerged for directly targeting constituent members of this cascade, predominantly in the context of cancer treatment. These approaches are still insufficient due to undesirable drug toxicity, resistance, and low efficacy. Significant advances have been made in understanding the spatiotemporal features of the constituent members of the RTK-RAS-MAPK axis, which are linked and modulated by many accessory proteins. Given that the majority of such modulators are now emerging as attractive therapeutic targets, a very small number of accessory inhibitors have yet to be discovered.
['Pudewell|Silke|S|', 'Ahmadian|Mohammad Reza|MR|']
D045744:Cell Line, Tumor D019008:Drug Resistance, Neoplasm D006801:Humans D020935:MAP Kinase Signaling System D020928:Mitogen-Activated Protein Kinases D047428:Protein Kinase Inhibitors D020794:Receptor Protein-Tyrosine Kinases D015398:Signal Transduction D018631:ras Proteins
ERK KRAS MEK RAF kinase RTK adaptor proteins anchoring proteins docking proteins scaffold proteins