The relationship between ANT1 and NFL with autophagy and mitophagy markers in patients with multiple sclerosis.
Multiple sclerosis (MS) is the most common inflammatory neurodegenerative disease. Neurofilament light chain (NFL) is a novel adverting biomarker of axonal damage that suggested as a useful assistant in the monitoring of MS patients. It has been shown that the auto/mitophagy associated with MS pathogenesis. In this study, we aimed to study correlation between ATG5 and Parkin, as markers of autophagy and mitophagy respectively, with NFL and ANT1 in serum and cerebrospinal fluid (CSF) in MS subjects. ATG5, Parkin, NFL, and ANT1 levels were measured in a cross-sectional study of 40 MS patients compared with gender, age and BMI matching healthy volunteers. Based on our results, levels of ATG5, Parkin, and NFL significantly were elevated in both serum and CSF of MS patients comparing control individuals (p < 0.0001) but ANT1 levels significantly was decreased in both serum and CSF of MS patients comparing control individuals (p < 0.0001). The correlation indices between NFL, ANTI1, ATG5 and Parkin in both case and control groups showed a direct and moderate the correlation between ANTI1 and ATG5 in the CSF level of the control group (r = 0.554, P = 0.011). Our data support the feasibility of quantifying of NFL as a sensitive and clinically meaningful serum/CSF biomarker to follow-up nerve tissue injury in MS condition.
['Hassanpour|Mehdi|M|', 'Cheraghi|Omid|O|', 'Laghusi|Delara|D|', 'Nouri|Mohammad|M|', 'Panahi|Yunes|Y|']
D033741:Adenine Nucleotide Translocator 1 D000328:Adult D001343:Autophagy D000071187:Autophagy-Related Protein 5 D015415:Biomarkers D016022:Case-Control Studies D003430:Cross-Sectional Studies D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D063306:Mitophagy D009103:Multiple Sclerosis D016900:Neurofilament Proteins D044767:Ubiquitin-Protein Ligases
Autophagy Mitophagy Multiple sclerosis Neurofilament light chain Novel biomarkers