Pentraxins and Collectins: Friend or Foe during Pathogen Invasion?
Innate immunity serves as the frontline defence against invading pathogens. Despite decades of research, new insights are constantly challenging our understanding of host-elicited immunity during microbial infections. Recently, two families of humoral innate immune proteins, pentraxins and collectins, have become a major focus of research in the field of innate immunity. Pentraxins and collectins are key players in activating the humoral arm of innate immunity, taking centre stage in immunoregulation and disease modulation. However, increasing evidence suggests that pentraxins and collectins can also mediate pathogenic effects during some infections. Herein, we discuss the protective and pathogenic effects of pentraxins and collectins, as well as their therapeutic significance.
['Foo|Suan-Sin|SS|', 'Reading|Patrick C|PC|', 'Jaillon|Sébastien|S|', 'Mantovani|Alberto|A|', 'Mahalingam|Suresh|S|']
D001424:Bacterial Infections D002097:C-Reactive Protein D037222:Collectins D054884:Host-Pathogen Interactions D006801:Humans D056724:Immunity, Humoral D007113:Immunity, Innate D007249:Inflammation D037102:Lectins D037601:Mannose-Binding Lectin D008954:Models, Biological D037662:Pulmonary Surfactant-Associated Protein A D037663:Pulmonary Surfactant-Associated Protein D D000683:Serum Amyloid P-Component
pentraxins collectins pathogens humoral innate immunity mannose-binding lectin pentraxin 3