ADMET: ADipocyte METabolism mathematical model.
White fat cells have an important physiological role in maintaining triglyceride and free fatty acid levels due to their fundamental storage property, as well as determining insulin resistance. ADipocyte METabolism is a mathematical model that mimics the main metabolic pathways of human white fat cell, connecting inputs (composition of culture medium) to outputs (glycerol and free fatty acid release). It is based on a set of nonlinear differential equations, implemented in Simulink® and controlled by cellular energetic state. The validation of this model is based on a comparison between the simulation results and a set of experimental data collected from the literature.
['Micheloni|Alessio|A|', 'Orsi|Gianni|G|', 'De Maria|Carmelo|C|', 'Vozzi|Giovanni|G|']
D052438:Adipocytes, White D002384:Catalysis D003470:Culture Media D005230:Fatty Acids, Nonesterified D005990:Glycerol D006801:Humans D007328:Insulin D007333:Insulin Resistance D008954:Models, Biological D013997:Time Factors D014280:Triglycerides
adipocyte metabolism mathematical modelling biochemical pathways