T cell-lymphoma in the eyelid of a 9-year-old English Setter.
BACKGROUND
Eyelid tumours are frequently found in dogs, most of these being benign. In case of an ulcerating eyelid tumour, malignancy must be considered. We report a unique case of a low-grade peripheral T-cell lymphoma in the eyelid of a 9-year-old English Setter.


CASE PRESENTATION
A 9-year-old Setter presented with a 6-month history of an eyelid ulcer. A malignant eyelid neoplasm was suspected, and the lesion was surgically excised. No other treatment was applied, and 19 months after excision the dog was still well. Histopathology revealed a diffuse lymphocytic infiltrate in the eyelid skin. Ulceration of the epithelium was seen, and the underlying tumour was composed of round and poorly demarcated pleomorphic tumour cells. The cytoplasm was pale and the nuclei heterogeneous. Numerous mitoses were present. The tumour cells stained strongly for CD3. The final diagnosis was a peripheral T-cell lymphoma not otherwise specified (NOS).


CONCLUSIONS
This is the first described case of a solitary T-cell lymphoma NOS in the haired eyelid skin in a dog. Lymphoma should be considered in case of a persistent eyelid ulcer and a biopsy should be performed. T-cell lymphoma is generally an aggressive disease; however, indolent cases are well known, and as this case shows, complete excision of a solitary T-cell lymphoma can be curable. Canine cutaneous epitheliotropic T-cell lymphoma is an important differential diagnosis, which must be recognized as the prognosis is very poor and systemic treatment is mandatory. The sub-classification of canine lymphoma is not complete, and further studies are needed to identify lymphoma subgroups and provide treatment guidelines.
['Mikkelsen|Lauge Hjorth|LH|http://orcid.org/0000-0002-4110-6739', 'Holm|Frederik|F|', 'Clasen-Linde|Erik|E|', 'Engraff|Pernille|P|', 'Heegaard|Steffen|S|']
D000818:Animals D004283:Dog Diseases D004285:Dogs D005142:Eyelid Neoplasms D005143:Eyelids D016410:Lymphoma, T-Cell, Cutaneous D008297:Male D012878:Skin Neoplasms
Eyelid Dog T-cell Lymphoma Neoplasm Canine