Chronic pain in Gaucher disease: skeletal or neuropathic origin?
BACKGOUND
Pain is one of the most disabling symptoms of Gaucher disease. It is referred by the majority of Gaucher patients and often persists despite long-term enzyme replacement treatment. It has been mainly considered as nociceptive pain secondary to skeletal involvement but it is described even in the absence of bone disease without a clear explanation. In the last years an increasing number of reports have described the presence of neurological manifestation in Gaucher type 1 patients, including subclinical large fibre neuropathy. In our Gaucher clinic we have observed the recurrence of painful symptoms in a group of type 1 Gaucher patients even after a long-term enzyme replacement therapy.


METHODS
A cross-sectional study was designed to investigate the pathophysiology of pain in a cohort of 25 Gaucher patients (13 females, 12 males). Twenty-two patients received enzyme replacement therapy for a period of time ranging from 10 to >20 years, while three were new diagnosis. Pain was classified as bone or neurologic related on the basis of anamnestic data, clinical and electrophysilogical examinations. Intensity and quality of pain were recorded by Douleur Neuropathique en 4 questionnaire and Neuropathic Pain Symptom Inventory. Neuroalgological evaluation, quantitative sensory testing, nerve conduction studies and evaluation of epidermal nerve fibres density were performed. Comorbidities for peripheral neuropathy were excluded.


RESULTS
Thirteen patients complained of pain suggestive of neuropathic origin with proximal patchy distribution, six manifested severe pain paroxysmal, nine pinprick hypoesthesia and 17 thermal hypoesthesia. At quantitative sensory testing, all of them showed high cold thresholds with errata sensation (burning instead of cold), paradoxical heat sensation and mechanic hypoesthesia; three patients showed pressure pain hyperalgesia. Epidermal denervation was present in 19 patients, 12 of them with non-length dependent pattern.


CONCLUSIONS
These results confirm the role of peripheral neuropathy in Gaucher pain and demonstrate that skin denervation is as a constitutive feature of the disorder. In addition, they further confirm the existence of a continuum Gaucher phenotype, and provide a new interpretation of pain origin that should be considered for an appropriate disease management and to avoid unnecessary dose escalations of enzyme therapy.
['Devigili|Grazia|G|', 'De Filippo|Michele|M|', 'Ciana|Giovanni|G|', 'Dardis|Andrea|A|', 'Lettieri|Christian|C|', 'Rinaldo|Sara|S|', 'Macor|Daniela|D|', 'Moro|Alessandro|A|', 'Eleopra|Roberto|R|', 'Bembi|Bruno|B|0000-0003-0486-1329']
D000293:Adolescent D000328:Adult D002648:Child D002675:Child, Preschool D059350:Chronic Pain D003430:Cross-Sectional Studies D005260:Female D005776:Gaucher Disease D006801:Humans D008297:Male D008875:Middle Aged D009437:Neuralgia D012867:Skin D011795:Surveys and Questionnaires D055815:Young Adult
Neuropathic pain Peripheral neuropathy Bone pain Gaucher type 1 disease Small fibre neuropathy