Lab-on-a-Chip Platforms as Tools for Drug Screening in Neuropathologies Associated with Blood-Brain Barrier Alterations.
Lab-on-a-chip (LOC) and organ-on-a-chip (OOC) devices are highly versatile platforms that enable miniaturization and advanced controlled laboratory functions (i.e., microfluidics, advanced optical or electrical recordings, high-throughput screening). The manufacturing advancements of LOCs/OOCs for biomedical applications and their current limitations are briefly discussed. Multiple studies have exploited the advantages of mimicking organs or tissues on a chip. Among these, we focused our attention on the brain-on-a-chip, blood-brain barrier (BBB)-on-a-chip, and neurovascular unit (NVU)-on-a-chip applications. Mainly, we review the latest developments of brain-on-a-chip, BBB-on-a-chip, and NVU-on-a-chip devices and their use as testing platforms for high-throughput pharmacological screening. In particular, we analyze the most important contributions of these studies in the field of neurodegenerative diseases and their relevance in translational personalized medicine.
['Staicu|Cristina Elena|CE|', 'Jipa|Florin|F|', 'Axente|Emanuel|E|0000-0003-1946-5863', 'Radu|Mihai|M|0000-0003-1128-8153', 'Radu|Beatrice Mihaela|BM|0000-0003-4421-2163', 'Sima|Felix|F|0000-0001-5911-0288']
D001812:Blood-Brain Barrier D004353:Drug Evaluation, Preclinical D057166:High-Throughput Screening Assays D006801:Humans D056656:Lab-On-A-Chip Devices D019636:Neurodegenerative Diseases
lab-on-a-chip drug screening organ-on-a-chip neurovascular unit blood brain barrier microfluidic platforms neurodegenerative disorders