The relationship between AASI and arterial atherosclerosis in ESRD patients.
OBJECTIVE
To explore the relationship between ambulatory blood pressure and arterial atherosclerosis and provide simple and easy reference indicators for the prediction, prevention and prognosis of cardiovascular events in end-stage renal disease (ESRD) patients.


METHOD
This prospective study consecutively collected clinical data of 114 ESRD hospitalized patients in the Department of Nephrology, the First Affiliated Hospital of Nanjing Medical University during August 2012 to December 2012. The data included laboratory data, the ambulatory blood pressure monitoring (ABPM), carotid ultrasound, two-dimensional echocardiography and the prognosis scores of the death risk.


RESULTS
(1) A series of ABPM parameters were closely associated with atherosclerosis (p ≤ 0.05). Ambulatory Arterial Stiffness Index (AASI) was the most representative parameter of ABPM and also the best indicator for atherosclerosis (logistic regression analysis, p = 0.005). (2) AASI was a comprehensive index of atherosclerosis (p < 0.001), which was associated with the increase of left ventricular diameter (p = 0.028) and the risk of death (p < 0.001). The independent risk factors of AASI were the growth of the age (p < 0.001), elevated serum fibrinogen (p = 0.009) and reduced serum albumin (p = 0.022).


CONCLUSION
AASI, as the representative of ABPM parameters, related well to atherosclerosis, which implied a broader application of ABPM in ESRD patients.
['Zhang|Shu|S|', 'Mao|Hui-Juan|HJ|', 'Sun|Bing|B|', 'Wang|Ning-Ning|NN|', 'Zhang|Bo|B|', 'Zeng|Ming|M|', 'Xu|Lin|L|', 'Yu|Xiang-Bao|XB|', 'Liu|Jia|J|', 'Xing|Chang-Ying|CY|']
D000328:Adult D000368:Aged D050197:Atherosclerosis D018660:Blood Pressure Monitoring, Ambulatory D002339:Carotid Arteries D002681:China D004452:Echocardiography D005260:Female D006801:Humans D006973:Hypertension D007676:Kidney Failure, Chronic D008297:Male D008875:Middle Aged D011379:Prognosis D011446:Prospective Studies D012307:Risk Factors D059289:Vascular Stiffness
AASI atherosclerosis ESRD ABPM