Correlation between survival and tumour characteristics in patients with chondrosarcoma.
PURPOSE
To evaluate the correlation between survival and tumour characteristics in 23 patients with chondrosarcoma.


METHODS
Records of 15 men and 8 women aged 14 to 66 (mean, 37) years who were diagnosed with primary (n=19) or secondary (n=4) chondrosarcoma of the axial skeleton (n=8), proximal extremity (n=9), or distal extremity (n=6) were reviewed. The tumour diameter was <10 cm in 4 patients, 10-19 cm in 12, and 20-30 cm in 7. The tumour involved the intramedullary in 17 and the periosteum in 6 patients; tumour extension was intracompartmental in 5 and extracompartmental in 18 patients. The Evans histological grade for the tumours was grade 1 in 6 patients, grade 2 in 10, and grade 3 in 7. The mean tumour size was 12.3 cm for grade 1 tumours, 18.2 cm for grade 2 tumours, and 18.3 cm for grade 3 tumours. 13 patients had no metastasis and 3 of 10 patients with grade 2 tumours and all 7 patients with grade 3 tumours had metastasis to the lung at presentation. 17 patients underwent surgery, one underwent adjuvant treatment only, and 5 declined treatment.


RESULTS
The mean follow-up period for the 23 patients was 3.1 years (range, 3 weeks to 9 years). The 5-year survival rate was 43% overall, 83.3% for grade 1 tumours, 50% for grade 2 tumours, and 0% for grade 3 tumours. The median survival duration was 20 (95% confidence interval, 11-29) months. Two patients had local recurrence and 16 did not, and the 5 patients who declined treatment died. Survival correlated with Evans histological grading (p=0.004), the presence of metastasis at presentation (p=0.026) and local recurrence (p=0.004).


CONCLUSION
The survival rate was lower in patients with higher Evan grading, metastasis, or local recurrence.
['Kamal|Achmad Fauzi|AF|', 'Husodo|Kurniadi|K|', 'Prabowo|Yogi|Y|', 'Hutagalung|Errol Untung|EU|']
D000293:Adolescent D000328:Adult D000368:Aged D001859:Bone Neoplasms D002813:Chondrosarcoma D005260:Female D005500:Follow-Up Studies D006801:Humans D007214:Indonesia D008297:Male D008875:Middle Aged D015996:Survival Rate D013997:Time Factors D055815:Young Adult
chondrosarcoma survival analysis