Prognostic factors associated with survival in patients with primary duodenal adenocarcinoma.
BACKGROUND/AIMS
The prognostic factors in primary duodenal adenocarcinoma remain controversial. This study evaluated the prognostic factors associated with survival in patients with primary duodenal adenocarcinoma.


METHODS
From March 1996 to June 2008, the medical records of 30 patients with a final diagnosis of primary duodenal epithelial malignancy seen at two referral centers were reviewed retrospectively. The prognostic factors for survival were evaluated 6 months and 1, 2, and 5 years after the diagnosis.


RESULTS
The median survival was 5.7 months. The survival rate was 46.7% (14/30), 16.7% (5/30), 10% (3/30), and 6.7% (2/30) at 6 months and 1, 2, and 5 years, respectively. Multivariate analysis showed that cancer-directed treatment, including curative surgery or chemotherapy, was a common independent risk factor at all follow-up times. Total bilirubin, cytology, and TNM stage were independent risk factors for survival at 1, 2, and 5 years. The white blood cell count was an independent risk factor at 1 year only. The actuarial probability of survival in patients undergoing cancer-directed treatment was significantly higher than in those without treatment at 6 months (71.4 vs. 25.0%, p < 0.01), 1 year (28.6 vs. 6.3%, p < 0.01), 2 years (21.4 vs. 0%, p < 0.01), and 5 years (14.3 vs. 0%, p < 0.01).


CONCLUSIONS
The prognostic factors in patients with primary duodenal adenocarcinoma were total bilirubin, TNM stage, cytology, and cancer-directed treatments until the 5-year follow-up. Especially, cancer-directed treatments improved patient survival.
['Chung|Woo Chul|WC|', 'Paik|Chang Nyol|CN|', 'Jung|Sung Hoon|SH|', 'Lee|Kang-Moon|KM|', 'Kim|Sang Woo|SW|', 'Chang|U-Im|UI|', 'Yang|Jin Mo|JM|']
D000230:Adenocarcinoma D000328:Adult D000368:Aged D000369:Aged, 80 and over D004379:Duodenal Neoplasms D005260:Female D017051:Hospice Care D006801:Humans D008297:Male D008875:Middle Aged D009367:Neoplasm Staging D011379:Prognosis
Cancer-directed treatment Duodenal cacner Prognosis