Extended spectrum of antibiotic susceptibility for tuberculosis, Djibouti.
In the Horn of Africa, there is a high prevalence of tuberculosis that is reported to be partly driven by multidrug-resistant (MDR) Mycobacterium tuberculosis strictu sensu strains. We conducted a prospective study to investigate M. tuberculosis complex species causing tuberculosis in Djibouti, and their in vitro susceptibility to standard anti-tuberculous antibiotics in addition to clofazimine, minocycline, chloramphenicol and sulfadiazine. Among the 118 mycobacteria isolates from 118 successive patients with suspected pulmonary tuberculosis, 111 strains of M. tuberculosis, five Mycobacterium canettii, one 'Mycobacterium simulans' and one Mycobacterium kansasii were identified. Drug-susceptibility tests performed on the first 78 isolates yielded nine MDR M. tuberculosis isolates. All isolates were fully susceptible to clofazimine, minocycline and chloramphenicol, and 75 of 78 isolates were susceptible to sulfadiazine. In the Horn of Africa, patients with confirmed pulmonary tuberculosis caused by an in vitro susceptible strain may benefit from anti-leprosy drugs, sulfamides and phenicol antibiotics.
['Bouzid|Fériel|F|', 'Astier|Hélène|H|', 'Osman|Djaltou Aboubaker|DA|', 'Javelle|Emilie|E|', 'Hassan|Mohamed Osman|MO|', 'Simon|Fabrice|F|', 'Garnotel|Eric|E|', 'Drancourt|Michel|M|']
D000328:Adult D000995:Antitubercular Agents D002701:Chloramphenicol D002991:Clofazimine D015730:Djibouti D005260:Female D006801:Humans D008297:Male D008826:Microbial Sensitivity Tests D008875:Middle Aged D008911:Minocycline D019909:Mycobacterium kansasii D009169:Mycobacterium tuberculosis D011446:Prospective Studies D013411:Sulfadiazine D018088:Tuberculosis, Multidrug-Resistant D014397:Tuberculosis, Pulmonary
Horn of Africa Mycobacterium tuberculosis Mycobacterium canettii Mycobacterium kansasii ‘Mycobacterium simulans’