Clinical and transcriptional signatures of human CD204 reveal an applicable marker for the protumor phenotype of tumor-associated macrophages in breast cancer.
BACKGROUND
Tumor-associated macrophages in human breast cancer are poorly understood. Specific tumor-associated macrophage-related molecular mechanisms among different intrinsic molecular subtypes remain unclear. Here, we have identified and explored the roles of the tumor-associated macrophages novel marker: CD204 in different subtypes of breast cancer.


RESULTS
CD204 was upregulated in four subtypes of breast cancer, and this was associated with poor survival outcomes. CD204 could promote tumor cell proliferation, migration, and invasion and was involved in immune system-related pathways among all subtypes. Special pathways in each subtype were also found. High CD204 mRNA expressions were associated with high proportions of protumor immune cell populations, and most immunoinhibitors positive correlated with CD204 expression in all subtypes.


CONCLUSIONS
These findings contribute to a better understanding and managing the protumor phenotype of tumor-associated macrophages in different subtypes of breast cancer.


METHODS
The expression of CD204 and its clinical outcome were analyzed. The roles of CD204 in the regulation of tumor cell proliferation, migration, and invasion were studied. Potential pathways influenced by CD204 were displayed. Immune cell infiltration in different CD204 mRNA expression status and correlations between CD204 and immunoinhibitors were also analyzed.
['He|Yunjie|Y|', 'Zhou|Siying|S|', 'Deng|Fei|F|', 'Zhao|Shujie|S|', 'Chen|Wenquan|W|', 'Wang|Dandan|D|', 'Chen|Xiu|X|', 'Hou|Juncheng|J|', 'Zhang|Jian|J|', 'Zhang|Wei|W|', 'Ding|Li|L|', 'Tang|Jinhai|J|', 'Zhou|Zuomin|Z|']
D014408:Biomarkers, Tumor D001943:Breast Neoplasms D045744:Cell Line, Tumor D005260:Female D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008264:Macrophages D012333:RNA, Messenger D051117:Scavenger Receptors, Class A D059467:Transcriptome D059016:Tumor Microenvironment
CD204 tumor-associated macrophage breast cancer subtypes of breast cancer tumor immune microenvironment