Influence of chest conformation on myocardial strain parameters in healthy subjects with mitral valve prolapse.
Chest shape might affect myocardial strain parameters. However, the relationship between myocardial strain parameters and chest conformation has not been previously investigated in subjects with mitral valve prolapse (MVP). Between April 2019 and May 2020, 60 healthy subjects (50.1 ± 8.6 year/old, 46.6% females) with MVP and mild-to-moderate mitral regurgitation, and 60 controls matched by age, sex, and cardiovascular risk factors were consecutively studied. Participants underwent modified Haller index (MHI) assessment (ratio of chest transverse diameter over the distance between sternum and spine), and transthoracic echocardiography implemented with 2D-speckle tracking analysis. MHI was significantly greater in MVP group than controls (2.6 ± 0.35 vs 2.1 ± 0.23, p < 0.0001). Left ventricular (LV) ejection fraction was similar in MVP and controls (63.5 ± 3.7% vs 64.3 ± 3.9%, p = 0.25). LV regional and global longitudinal (GLS), circumferential (GCS) and radial strain (GRS) parameters and LV peak twist were all significantly lower in MVP compared to controls (all p < 0.0001). MVP subjects with a tight chest (MHI > 2.5, n = 30), and those with MHI ≤ 2.5 (n = 30) were then separately analyzed. A significant impairment in myocardial strain parameters and LV peak twist was documented in MVP subjects with MHI > 2.5, but not in those with MHI ≤ 2.5. MHI showed a strong inverse correlation with LV-GLS (r = - 0.85), GCS (r = - 0.84), GRS (r = - 0.84) and LV peak twist (r = - 0.94). In MVP subjects, impairment of myocardial strain parameters is not due to intrinsic reduction of cardiac contractility function, but it appears to be related to the degree of chest deformity.
['Sonaglioni|Andrea|A|', 'Nicolosi|Gian Luigi|GL|', 'Lombardo|Michele|M|', 'Gensini|Gian Franco|GF|', 'Ambrosio|Giuseppe|G|']
D000328:Adult D059925:Anatomic Landmarks D000886:Anthropometry D001696:Biomechanical Phenomena D016022:Case-Control Studies D015150:Echocardiography, Doppler D005260:Female D006304:Health Status D006801:Humans D008297:Male D008875:Middle Aged D008943:Mitral Valve D008944:Mitral Valve Insufficiency D008945:Mitral Valve Prolapse D009200:Myocardial Contraction D011237:Predictive Value of Tests D011446:Prospective Studies D013318:Stroke Volume D013909:Thorax D016277:Ventricular Function, Left
Myocardial strain Mitral valve prolapse Haller index