Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG® KO Mice.
Mice with humanized chimeric liver are promising in vivo tools to evaluate the efficacy of novel compounds or vaccine induced antibodies directed against pathogens that infect the human liver. In addition they can be used to study the human-type metabolism of medicinal compounds and hepatotoxicity.
['Foquet|Lander|L|', 'Wilson|Elizabeth M|EM|', 'Verhoye|Lieven|L|', 'Grompe|Markus|M|', 'Leroux-Roels|Geert|G|', 'Bial|John|J|', 'Meuleman|Philip|P|']
D000090:Acetoacetates D000818:Animals D017690:Cell Transplantation D056486:Chemical and Drug Induced Liver Injury D004195:Disease Models, Animal D022781:Hepatocytes D006801:Humans D006867:Hydrolases D008099:Liver D051379:Mice D018345:Mice, Knockout D016513:Mice, SCID D018183:Transplantation Chimera D014568:Urokinase-Type Plasminogen Activator
Liver In vivo Metabolism Humanized mouse model Malaria Plasmodium falciparum Viral hepatitis