Phage Display Technology and its Applications in Cancer Immunotherapy.
BACKGROUND
Phage display is an effective technology for generation and selection targeting protein for a variety of purpose, which is based on a direct linkage between the displayed protein and the DNA sequence encoding it and utilized in selecting peptides, improving peptides affinity and indicating protein-protein interactions. Phage particles displaying peptide have the potential to apply in the identification of cell-specific targeting molecules, identification of cancer cell surface biomarkers, identification anti-cancer peptide, and the design of peptide-based anticancer therapy.


METHOD/RESULTS
Literature searches, reviews and assessments about Phage were performed in this review from PubMed and Medline databases.


CONCLUSION
The phage display technology is an inexpensive method for expressing exogenous peptides, generating unique peptides that bind any given target and investigating protein-protein interactions. Due to the powerful ability to insert exogenous gene and display exogenous peptides on the surface, phages may represent a powerful peptide delivery system that can be utilized to develop rapid, efficient, safe and inexpensive cancer therapy methods.
['Wang|Yicun|Y|', 'Gao|Shuohui|S|', 'Lv|Jiayin|J|', 'Lin|Yang|Y|', 'Zhou|Li|L|', 'Han|Liying|L|']
D061505:Cell Surface Display Techniques D006801:Humans D007167:Immunotherapy D009369:Neoplasms D010455:Peptides
Phage cancer immunotherapy protein-protein interactions. anti-cancer protein targeting