Cross-protection between experimental anti-leptospirosis bacterins.
We investigated the existence of cross-protection between two anti-leptospirosis monovalent experimental bacterins produced with two strains of Leptospira serogroup Pomona: Fromm strain of serovar Kennewicky, isolated from pigs in the United States, and strain GR6 of serovar Pomona isolated from pigs in Brazil. Both were added of aluminum hydroxide as an adjuvant. Experimental bacterins were tested with the hamster potency test in order to assess protection provided against the disease and against the establishment of kidney infection. Controls were polyvalent commercial vaccine produced with Leptospira strains isolated outside Brazil, which included a representative of Pomona serovar, or Sorensen solution added of aluminum hydroxide adjuvant. The challenge was performed with cross-strains of serogroup Pomona tested in accordance with international standards established for the potency test. After 21 days of the challenge, survivors were killed to evaluate the condition of Leptospira renal carrier. Experimental bacterins protected hamsters against homologous and heterologous strains, demonstrating the existence of cross-protection. The commercial vaccine protected the hamsters challenged with both strains, but there was a high proportion of animals diagnosed as renal carriers when the challenge was performed with strain GR6, isolated from pigs in Brazil.
['Dib|Cristina Corsi|CC|', 'Gonçales|Amane Paldês|AP|', 'de Morais|Zenaide Maria|ZM|', 'de Souza|Gisele Oliveira|GO|', 'Miraglia|Fabiana|F|', 'Abreu|Patricia Antonia Estima|PA|', 'Vasconcellos|Silvio Arruda|SA|']
D000276:Adjuvants, Immunologic D000536:Aluminum Hydroxide D000818:Animals D001428:Bacterial Vaccines D002353:Carrier State D006224:Cricetinae D056738:Cross Protection D007668:Kidney D007919:Leptospira D007922:Leptospirosis D016896:Treatment Outcome
cross-protection bacterin Pomona hamsters