Histologic changes in diabetic gastroparesis.
The cellular abnormalities that lead to diabetic gastroparesis are increasingly being understood. Several key cell types are affected by diabetes, leading to gastroparesis. These changes include abnormalities in the extrinsic innervation to the stomach, loss of key neurotransmitters at the level of the enteric nervous system, smooth muscle abnormalities, loss of interstitial cells of Cajal, and changes in the macrophage population resident in the muscle wall. This article reviews the current understanding with a focus on data from human studies when available.
['Farrugia|Gianrico|G|']
D003922:Diabetes Mellitus, Type 1 D003924:Diabetes Mellitus, Type 2 D003929:Diabetic Neuropathies D005746:Gastric Emptying D018589:Gastroparesis D006801:Humans D056885:Interstitial Cells of Cajal D008264:Macrophages D009130:Muscle, Smooth D013270:Stomach
Smooth muscle Interstitial cells of Cajal Macrophages Enteric nerves Gastric emptying Vagus