Nonpharmacologic Management of Hepatic Encephalopathy: An Update.
Research increasingly shows that the gut-liver-brain axis is a crucial component in the pathophysiology of hepatic encephalopathy (HE). Due to the limitations of current standard-of-care medications, non-pharmacological treatments that target gut dysbiosis, including probiotics, nutritional management, and fecal microbiota transplants, are being considered as alternative and adjunct therapies. Meta-analyses note that probiotics could offer benefits in HE treatment, but have not shown superiority over lactulose. Emerging literature suggests that fecal microbiota transplants could offer a novel strategy to treat gut dysbiosis and favorably impact HE. Finally, liver support devices and liver transplantation could offer a last-resort treatment option for persistent HE.
['Weir|Vanessa|V|', 'Reddy|K Rajender|KR|']
D000597:Amino Acids, Branched-Chain D004044:Dietary Proteins D002149:Energy Intake D000069467:Fecal Microbiota Transplantation D000069196:Gastrointestinal Microbiome D006501:Hepatic Encephalopathy D006801:Humans D016031:Liver Transplantation D019164:Liver, Artificial D056692:Prebiotics D019936:Probiotics D058616:Synbiotics
Nonpharmacologic Hepatic encephalopathy Probiotics Nutrition Fecal microbiota transplant Branched-chain amino acids Gut microbiome Prebiotics