Designing peptide nanoparticles for efficient brain delivery.
The targeted delivery of therapeutic compounds to the brain is arguably the most significant open problem in drug delivery today. Nanoparticles (NPs) based on peptides and designed using the emerging principles of molecular engineering show enormous promise in overcoming many of the barriers to brain delivery faced by NPs made of more traditional materials. However, shortcomings in our understanding of peptide self-assembly and blood-brain barrier (BBB) transport mechanisms pose significant obstacles to progress in this area. In this review, we discuss recent work in engineering peptide nanocarriers for the delivery of therapeutic compounds to the brain: from synthesis, to self-assembly, to in vivo studies, as well as discussing in detail the biological hurdles that a nanoparticle must overcome to reach the brain.
['Duro-Castano|Aroa|A|', 'Moreira Leite|Diana|D|', 'Forth|Joe|J|', 'Deng|Yangwei|Y|', 'Matias|Diana|D|', 'Noble Jesus|Carlos|C|', 'Battaglia|Giuseppe|G|']
D000281:Administration, Intranasal D000818:Animals D001692:Biological Transport D001812:Blood-Brain Barrier D001921:Brain D016503:Drug Delivery Systems D004343:Drug Implants D006801:Humans D053758:Nanoparticles D010455:Peptides D011994:Recombinant Proteins
Peptides Drug delivery Self-assembly Alzheimer’s disease Blood–brain barrier Glioma Parkinson’s disease Transcytosis