CdS nanoparticles of different lengths induce differential responses in some of the liver functions of mice.
Cadmium sulfide nanoparticles (CdS NPs) are one of important nanoparticle materials which are widely used in photoelectric production, but their potential health hazard to the liver is not clear. This study is aimed at exploring the possible mechanisms of liver injury induced by CdS NPs. Male mice were treated with nanoparticles of 110-130 nm and 80-100 nm cadmium sulfide. The main methods were based on detecting the vigor of superoxide dismutase (SOD) and glutathione (GSH), and content of malondialdehyde (MDA) in both blood and liver tissues as well as on observing the pathological changes in liver tissue. CdS NPs suppressed the activity of SOD and GSH, and increased the serum MDA content (p < 0.05); both effects were observed together in liver tissues of 80-100 nm group (p < 0.05) and were accompanied by an obviously inflammatory response. CdS NPs induced oxidative damage and inflammatory response in liver tissue, which may be an underlying mechanism for its pulmonary toxicity. Additionally, the toxicity of CdS NPs was closely related to the size of nanoparticles. Pathological results showed that the hepatotoxicity of shorter CdS NPs is greater than that of longer CdS NPs (Tab. 6, Fig. 3, Ref. 20).
['Li|Q Z|QZ|', 'Sun|J|J|', 'Shen|H T|HT|', 'Jia|S F|SF|', 'Bai|D S|DS|', 'Ma|D|D|']
D000818:Animals D019187:Cadmium Compounds D056486:Chemical and Drug Induced Liver Injury D005978:Glutathione D008099:Liver D008297:Male D008315:Malondialdehyde D051379:Mice D053758:Nanoparticles D013440:Sulfides D013482:Superoxide Dismutase
cadmium sulfide nanoparticles oxidative damage inflammation.