Increased intestinal permeability as a risk factor for type 2 diabetes.
AIM
Relationships between the intestinal microbiota, intestinal permeability and inflammation in the context of risk for obesity-associated disease continue to be of interest. The aim of the study was to examine the associations between intestinal permeability and type 2 diabetes (T2D).


METHODS
A total of 130 individuals with T2D (age: 57.5±6.2 years (mean±SD); BMI: 30.4±3.2; 45% female) and 161 individuals without T2D (age: 37.4±12.5 years; BMI: 25.1±3.9; 65% female) were included in the study. Assessment of intestinal permeability included measurement of circulating lipopolysaccharide (LPS), LPS-binding protein (LBP) and intestinal fatty acid binding protein (iFABP) concentrations, which were used for calculation of a derived permeability risk score (PRS). Associations between permeability measures and T2D status were assessed using logistic regression models.


RESULTS
LBP (∼34%, P<0.001), iFABP (∼46%, P<0.001) and the PRS (∼24% P<0.001) were all significantly higher in the T2D affected individuals. Individuals with a PRS in the upper tertile were 5.07 times more likely (CI: 1.72-14.95; P=0.003) to have T2D when models were adjusted for age, sex and BMI. There was a trend towards improved prediction when including the PRS in models containing age, sex and BMI (AUC: 0.954 versus 0.962; P=0.06).


CONCLUSION
These data demonstrate differences in measures of intestinal permeability between individuals with and without T2D. The utility of using intestinal permeability measures as a tool for predicting T2D risk in at risk individuals should be further investigated.
['Cox|A J|AJ|', 'Zhang|P|P|', 'Bowden|D W|DW|', 'Devereaux|B|B|', 'Davoren|P M|PM|', 'Cripps|A W|AW|', 'West|N P|NP|']
D000209:Acute-Phase Proteins D000293:Adolescent D000328:Adult D000368:Aged D001794:Blood Pressure D002352:Carrier Proteins D003924:Diabetes Mellitus, Type 2 D050556:Fatty Acid-Binding Proteins D005260:Female D006801:Humans D007413:Intestinal Mucosa D008070:Lipopolysaccharides D008297:Male D008562:Membrane Glycoproteins D008875:Middle Aged D010539:Permeability D012307:Risk Factors D055815:Young Adult
Intestinal permeability Diabetes Inflammation Prediction