Current status and perspectives on protein-based pneumococcal vaccines.
Despite the efforts to expand the availability of conjugate vaccines, pneumococcal diseases still pose an enormous burden worldwide. Therefore, several proteins have been investigated as alternative vaccines, alone or in combination with other antigens. With an increasing array of techniques, many of which arose from the publication of the bacterial genome, several proteins have been identified as potential vaccine candidates, and some have even progressed to clinical trials. Also, whole cell vaccines are being studied for the induction of broad ranging protective responses. Here, we briefly summarize the current knowledge on pneumococcal proteins that are being investigated as potential vaccine candidates against pneumococcal infections, and provide an insight on the future generation of protein-based vaccines against Streptococcus pneumoniae.
['Darrieux|Michelle|M|', 'Goulart|Cibelly|C|', 'Briles|David|D|', 'Leite|Luciana Cezar de Cerqueira|LC|']
D000942:Antigens, Bacterial D001426:Bacterial Proteins D055808:Drug Discovery D006801:Humans D011008:Pneumococcal Infections D022242:Pneumococcal Vaccines D013296:Streptococcus pneumoniae D014614:Vaccines, Synthetic
vaccine Pneumococcal proteins Streptococcus pneumoniae