Human Semen Quality, Sperm DNA Damage, and the Level of Urinary Concentrations of 1N and TCPY, the Biomarkers of Nonpersistent Insecticides.
The aim of the study was to evaluate the association between environmental exposure to nonpersistent insecticides and semen quality (concentration, motility, morphology, computer-aided semen analysis [CASA] parameters, and sperm DNA damage). Urine samples ( n = 315) collected from men who attended the infertility clinic with normal semen concentration of 15 to 300 mln/ml and age under 45 years were analyzed for two metabolites (1-naphthol [1N] and 3,5,6-trichloro-2-pyridinol [TCPY]) of nonpersistent insecticides. Participants provided semen, blood, and saliva samples; additionally, men filled a detailed questionnaire. The results identified that urinary TCPY concentration was significantly associated with a decrease in motility; also there was a positive association between TCPY and DNA fragmentation index (DFI). 1N concentration was negatively associated with a percentage of sperm with normal morphology and positively with one of the CASA parameters (curvilinear velocity [VCL]). The results suggest that environmental exposure to nonpersistent insecticides may have an impact on semen quality parameters and sperm DNA damage.
['Dziewirska|Emila|E|0000-0002-1939-2812', 'Radwan|Michał|M|', 'Wielgomas|Bartosz|B|', 'Klimowska|Anna|A|0000-0002-7519-006X', 'Radwan|Paweł|P|', 'Kałużny|Paweł|P|', 'Hanke|Wojciech|W|', 'Słodki|Maciej|M|', 'Jurewicz|Joanna|J|']
D000328:Adult D015331:Cohort Studies D004249:DNA Damage D004781:Environmental Exposure D006801:Humans D007306:Insecticides D008297:Male D008875:Middle Aged D015999:Multivariate Analysis D009284:Naphthols D011044:Poland D012044:Regression Analysis D012189:Retrospective Studies D055101:Semen Analysis D013094:Spermatozoa
semen quality DNA damage carbaryl chlorpyrifos