Coronary artery calcification: pathogenesis and prognostic implications.
Coronary artery calcification (CAC) is a risk factor for adverse outcomes in the general population and in patients with coronary artery disease. The pathogenesis of CAC and bone formation share common pathways, and risk factors have been identified that contribute to the initiation and progression of CAC. Efforts to control CAC with medical therapy have not been successful. Event-free survival is also reduced in patients with coronary calcification after both percutaneous coronary intervention (PCI) and bypass graft surgery. Although drug-eluting stents and devices for plaque modification have modestly improved outcomes in calcified vessels, adverse event rates are still high. Innovative pharmacologic and device-based approaches are needed to improve the poor prognosis of patients with CAC.
['Madhavan|Mahesh V|MV|', 'Tarigopula|Madhusudhan|M|', 'Mintz|Gary S|GS|', 'Maehara|Akiko|A|', 'Stone|Gregg W|GW|', 'Généreux|Philippe|P|']
D002114:Calcinosis D017023:Coronary Angiography D003324:Coronary Artery Disease D003937:Diagnosis, Differential D054855:Drug-Eluting Stents D014943:Global Health D006801:Humans D015994:Incidence D062645:Percutaneous Coronary Intervention D011379:Prognosis D014057:Tomography, X-Ray Computed
coronary artery calcification coronary artery disease PCI