Therapeutic approaches in the treatment of gout.
Gout is a disease in which the metabolic condition hyperuricemia leads to the formation of monosodium urate crystals, which provoke acute and chronic inflammatory responses through activation of the innate immune system. Recent advances in our knowledge of gout pathogenesis have emphasized the role of the kidneys in urate handling, the evolutionary loss of uricase as a necessary precondition for hyperuricemia, and the central role of IL-1ß in the pathogenesis of gouty inflammation. These, and other advances, have shaped our current strategies for managing gout. Here, we review the most current, evidence-based gout management approaches, including treating acute flares, addressing gout through the long-term regulation of serum urate, and prophylaxis against gouty flares during urate lowering.
['Pillinger|Michael H|MH|', 'Mandell|Brian F|BF|']
D000894:Anti-Inflammatory Agents, Non-Steroidal D005260:Female D006073:Gout D006074:Gout Suppressants D006801:Humans D033461:Hyperuricemia D008297:Male D000067251:Symptom Flare Up D014527:Uric Acid
Treatment Gout Allopurinol Colchicine Pegloticase