Confirmation of quinolone-induced formation of gyrase-DNA conjugates using AFM.
It was demonstrated in our studies that norfloxacin, a representative member of quinolone antibiotics, can indeed stabilize the gyrase-DNA complex formed during enzymatic cycle. In addition, the formation of the drug-induced complex has been firstly visualized through our atomic force microscopic examination.
['Zhang|Hao|H|', 'Guo|Juanjuan|J|', 'Li|Dawei|D|', 'Ng|Magdeline Tao Tao|MT|', 'Lee|Jasmine Yiqin|JY|', 'Lv|Bei|B|', 'Ng|Chee Wee|CW|', 'Lee|Selvi|S|', 'Shao|Fangwei|F|', 'Li|Tianhu|T|']
D000900:Anti-Bacterial Agents D027081:DNA Gyrase D004587:Electrophoresis, Agar Gel D004795:Enzyme Stability D018625:Microscopy, Atomic Force D015394:Molecular Structure D009643:Norfloxacin D011804:Quinolines
AFM Norfloxacin Quinolone Complexes Gyrase