Etiological Observations in Seven Patients with Pancreatic Neuroendocrine Tumors (PNETs).
BACKGROUND/AIM
Pancreatic neuroendocrine tumors (PNETs) are uncommon malignancies of largely unknown pathogenesis. Observations on patients and their families can provide clues on etiology.


PATIENTS AND METHODS
In a medical oncology practice cohort of 2,087 patients 5 females and 2 males with PNETs have been identified.


RESULTS
Observations of etiologic interest have been made in 2 patients with PNETs. One female patient belongs to a kidney cancer family with a balanced translocation t(3;11)(q13;q21). A second female patient with PNET had a de novo translocation (t3;5)(q27;q14), its braking point could contain a tumor suppressor gene.


CONCLUSION
Chromosome studies in patients with PNETs point to an etiologic role of balanced translocations.
['Landin|Julia|J|', 'Weber|Walter|W|']
D000328:Adult D000368:Aged D005190:Family D005260:Female D005500:Follow-Up Studies D006801:Humans D008297:Male D018811:Maternal Exposure D008875:Middle Aged D018358:Neuroendocrine Tumors D010190:Pancreatic Neoplasms D011247:Pregnancy D011297:Prenatal Exposure Delayed Effects D014178:Translocation, Genetic D055815:Young Adult
Pancreatic neuroendocrine tumor PNET cancer etiology