A Novel Lid Hygiene Detergent Successfully Eliminated Demodex Mites, a Common Pathogen of Refractory Obstructive Meibomian Gland Dysfunction.
INTRODUCTION
Demodex mites are microscopic arthropods that have been shown to be responsible for chronic blepharitis. Although many reports have demonstrated positive effects of lid hygiene on demodicosis, some have produced conflicting results. We retrospectively evaluated the effect of lid margin cleansing with a novel lid hygiene detergent, Eye Shampoo, in patients with ocular demodicosis.


METHODS
Outpatient clinic notes recorded over a 24-month period between June 30, 2016, and June 29, 2018, at Keio University Hospital in Japan were reviewed to identify patients diagnosed with ocular demodicosis who started cleansing their lid margins with Eye Shampoo at least once daily as a lid hygiene therapy.


RESULTS
Five patients diagnosed with ocular demodicosis who started cleansing their lid margins using Eye Shampoo for lid hygiene were identified. In four cases, Demodex mites were successfully eliminated, and ocular conditions were ultimately improved with no recurrence. Active Demodex mites were still noted after 3 months of lid hygiene therapy in one case; further observation of this case was not available. There were no adverse effects of Eye Shampoo in any of these cases.


CONCLUSION
Lid hygiene therapy using Eye Shampoo successfully eliminated Demodex mites, a common pathogen of refractory obstructive meibomian gland dysfunction.
['Tanabe|Hirotaka|H|http://orcid.org/0000-0002-1948-7408', 'Nakamura|Shigeru|S|', 'Kawashima|Motoko|M|', 'Ishida|Reiko|R|', 'Kaido|Minako|M|', 'Mizuno|Miki|M|', 'Sato|Enrique A|EA|', 'Inoue|Sachiko|S|', 'Ayaki|Masahiko|M|', 'Tsubota|Kazuo|K|']
D000328:Adult D000368:Aged D000818:Animals D003902:Detergents D005260:Female D006801:Humans D006920:Hygiene D008297:Male D000080343:Meibomian Gland Dysfunction D008537:Meibomian Glands D008925:Mites
lid hygiene Demodex mites Eye Shampoo ocular demodicosis