Influence of Cystic Fibrosis-Related Diabetes on Mental Health in Adults: A Single-Center Study.
PURPOSE
People with cystic fibrosis (CF) are predisposed to chronic conditions, such as CF-related diabetes (CFRD). Recent attention has been focused on the addition of screening for anxiety and depression in the CF population. Independently, CFRD and mental health conditions are associated with worse clinical outcomes; however, research assessing the impact of both conditions together is limited. We aimed to characterize the association between CFRD and selected diagnoses of anxiety or depressive disorders on clinical outcomes in adults with CF.


METHODS
A single-center, retrospective, cross-sectional study in adult patients with CF was performed. Group comparisons included selected diagnoses of depression, anxiety, and CFRD using two-sample t-tests or rank-sum tests for continuous variables, and Chi-square or Fisher's exact tests for categorical variables.


RESULTS
A total of 209 adults were enrolled (mean age of 31.4 ± 11.4 years). Those with a selected diagnoses of depression had a significantly higher proportion of CFRD than those without depression (48% vs. 28%, respectively, p = 0.005), and CFRD was associated with increased odds of depression [OR (CI) = 2.33 (1.28, 4.26), p = 0.006]. We did not see a higher proportion of adults with CFRD and selected diagnoses of anxiety than those without anxiety (41% vs. 31% respectively, p = 0.12), nor an increased odds of anxiety in those with CFRD [OR (CI) = 1.58 (0.88, 2.84), p = 0.12].


CONCLUSION
We show a significant association between CFRD and selected diagnoses of depression in a cohort of adult patients.
['Hjelm|Michelle|M|http://orcid.org/0000-0003-4474-8021', 'Tumin|Dmitry|D|', 'Nemastil|Christopher J|CJ|', 'Salvator|Ann E|AE|', 'Hayes|Don|D|']
D000293:Adolescent D000328:Adult D000368:Aged D001008:Anxiety Disorders D003430:Cross-Sectional Studies D003550:Cystic Fibrosis D003866:Depressive Disorder D048909:Diabetes Complications D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D012189:Retrospective Studies D055815:Young Adult
Cystic fibrosis-related diabetes Cystic fibrosis Anxiety depression