Suppressive effect of SATB1 on hepatic stellate cell activation and liver fibrosis in rats.
Liver fibrosis is a worldwide clinical issue. Activation of hepatic stellate cells (HSCs) is the central event during liver fibrosis. We investigated the role of SATB1 in HSC activation and liver fibrogenesis. The results show that SATB1 expression is reduced during HSC activation. Additionally, SATB1 inhibits HSC activation, proliferation, migration, and collagen synthesis. Furthermore, CTGF, a pro-fibrotic agent, is also significantly inhibited by SATB1 through the Ras/Raf-1/MEK/ERK/Ets-1 pathway. In vivo, SATB1 deactivates HSCs and attenuates fibrosis in TAA-induced fibrotic rat livers. These data indicate that SATB1 plays an important role in HSC activation and liver fibrosis.
['He|Jiayi|J|', 'Gong|Jin|J|', 'Ding|Qiang|Q|', 'Tan|Qinghai|Q|', 'Han|Ping|P|', 'Liu|Jingmei|J|', 'Zhou|Zhenzhen|Z|', 'Tu|Wei|W|', 'Xia|Yujia|Y|', 'Yan|Wei|W|', 'Tian|Dean|D|']
D000199:Actins D000818:Animals D002460:Cell Line D002465:Cell Movement D049109:Cell Proliferation D002478:Cells, Cultured D003094:Collagen D055513:Connective Tissue Growth Factor D004195:Disease Models, Animal D005786:Gene Expression Regulation D020868:Gene Silencing D055166:Hepatic Stellate Cells D018398:Homeodomain Proteins D006801:Humans D008103:Liver Cirrhosis D020935:MAP Kinase Signaling System D008297:Male D036961:Matrix Attachment Region Binding Proteins D011897:Random Allocation D017207:Rats, Sprague-Dawley D011994:Recombinant Proteins
SATB1 Hepatic stellate cell Liver fibrosis Ras/Raf-1/MEK/ERK/Ets-1