Vitamin D status and thyroid autoimmunity in Korean pregnant women.
OBJECTIVE
There is increasing interest in the role of vitamin D (vitD) during pregnancy. We prospectively evaluated the vitD status in Korean pregnant women and evaluated the levels of vitD according to thyroid-specific autoimmunity during pregnancy.


METHODS
We included pregnant 531 women who visited for prenatal care and 238 age-matched, non-pregnant women as a control population. The levels of thyrotropin, FT4, thyroid peroxidase (TPO), thyroglobulin (Tg) antibody (Ab) and 25-hydroxy vitamin D [25(OH)D] were measured by electrochemiluminescence immunoassays.


RESULTS
The mean levels of 25(OH)D at trimester 1, 2 and 3 were 13.6, 15.6 and 19.3 ng/mL, respectively; and the prevalence of vitD insufficiency was 83.6%, 75.1% and 55.9%, respectively. The mean 25(OH)D levels were not significantly different between Tg and TPO Ab-positive and negative pregnant women (14.9 versus 16.1, and 14.9 versus 16.1 ng/mL, respectively).


CONCLUSIONS
vitD insufficiency was exceptionally high, especially in the first trimester, in Korean pregnant women. The mean 25(OH)D levels were not significantly different according to autoimmunity. Further studies on this relationship could provide important information to assess the vitD status in patients with thyroid autoimmunity during pregnancy.
['Moon|Hee-Won|HW|', 'Chung|Hee-Jung|HJ|', 'Hur|Mina|M|', 'Yun|Yeo-Min|YM|']
D000328:Adult D015415:Biomarkers D016022:Case-Control Studies D005260:Female D006801:Humans D008875:Middle Aged D011247:Pregnancy D011248:Pregnancy Complications D015995:Prevalence D011446:Prospective Studies D056910:Republic of Korea D013967:Thyroiditis, Autoimmune D014808:Vitamin D Deficiency
vitamin D thyroid Autoimmunity pregnancy