E-cadherin roles in animal biology: A perspective on thyroid hormone-influence.
The establishment, remodeling and maintenance of tissular architecture during animal development, and even across juvenile to adult life, are deeply regulated by a delicate interplay of extracellular signals, cell membrane receptors and intracellular signal messengers. It is well known that cell adhesion molecules (cell-cell and cell-extracellular matrix) play a critical role in these processes. Particularly, adherens junctions (AJs) mediated by E-cadherin and catenins determine cell-cell contact survival and epithelia function. Consequently, this review seeks to encompass the complex and prolific knowledge about E-cadherin roles during physiological and pathological states, particularly focusing on the influence exerted by the thyroid hormone (TH).
['Izaguirre|María Fernanda|MF|', 'Casco|Victor Hugo|VH|']
D022005:Adherens Junctions D000818:Animals D015820:Cadherins D051177:Catenins D004847:Epithelial Cells D019143:Evolution, Molecular D015398:Signal Transduction D013963:Thyroid Hormones
E-cadherin Development Adherens junction Epithelia Thyroid hormones Evolution