Memory-related process in physiological status and alzheimer's disease.
Rejecting central dogma around static status of adult mammalian brain, CNS has the nascent neurons generated in subgranular zone of dentate gyrus in hippocampus which develop to novel glutamatergic granule cells, with the innate feature of transmuting to memory disks. Structural plasticity proceeds with synaptic plasticity to process all the developing stages required to successful maturation and functional integration, whereby the memory context is ready to leave the hippocampus toward cortex network through consolidation process, for being installed and run the memory disk forever. However, in Alzheimer's disease, brain deal with subtle deadly progressive loss of synapsis, neuronal dysfunction and ultimately network failure, resulting in memory decay and cognitive decline-concluding that AD destroys memory formation related-pathways.
['Fotuhi|Seyedeh Nahid|SN|https://orcid.org/0000-0003-4287-7233', 'Khalaj-Kondori|Mohammad|M|', 'Feizi|Mohammad Ali Hoseinpour|MAH|', 'Talebi|Mahnaz|M|https://orcid.org/0000-0002-7613-3913']
D000544:Alzheimer Disease D000818:Animals D001921:Brain D004195:Disease Models, Animal D006624:Hippocampus D006801:Humans D008568:Memory D009415:Nerve Net D009473:Neuronal Plasticity D009474:Neurons
Hippocampus Memory formation Alzheimer’s disease Aβ peptide Neurogenesis