Immunotherapy in Acute Leukemias: Implications and Perspectives Using Wt1 Antigen.
The WT1 gene encodes a transcription factor involved in regulation of many cellular processes, including proliferation, differentiation, mRNA processing and apoptosis, besides acting as a transcription repressor of growth factors and their receptors' genes. This gene is expressed at high levels in several types of cancers, including acute leukemias. In this regard, many studies have identified WT1 protein as a tumor antigen, considered a target molecule for clinical application in human acute leukemias. Immunotherapy using WT1 antigen has been effective in stimulating immune responses against leukemic cells. Regarding adoptive immunotherapy, the use of dendritic cells (DCs) for the WT1-specific cytotoxic T cells generation proved to be efficient in the development and maintenance of immunologic cells. Therefore, these therapeutic methods, that provided enthusiasm for moving ahead, highlight several opportunities and challenges to be used in clinical practice for managing acute leukemias.
['Cebinelli|Guilherme Cesar Martelossi|GC|', 'DE Sousa Pereira|Nathália|N|', 'Sena|Michelle Mota|MM|', 'DE Oliveira|Carlos Eduardo Coral|CE|', 'Fujita|Thiago Cezar|TC|', 'DA Rocha|Sérgio Paulo Dejato|SP|', 'DE Abreu Oliveira|Francisco José|FJ|', 'Marinello|Poliana Camila|PC|', 'Watanabe|Maria Angelica Ehara|MA|']
D000951:Antigens, Neoplasm D017209:Apoptosis D002454:Cell Differentiation D049109:Cell Proliferation D003713:Dendritic Cells D006801:Humans D007167:Immunotherapy D007938:Leukemia D013602:T-Lymphocytes, Cytotoxic D025721:WT1 Proteins
acute leukemias WT1 antigens Adoptive immunotherapy review