Investigation of antitumor potential of Ni(II) complexes with tridentate PNO acylhydrazones of 2-(diphenylphosphino)benzaldehyde and monodentate pseudohalides.
Square-planar azido Ni(II) complex with condensation product of 2-(diphenylphosphino)benzaldehyde and Girard's T reagent was synthesized and its crystal structure was determined. Cytotoxic activity of the azido complex and previously synthesized isothiocyanato, cyanato and chlorido Ni(II) complexes with this ligand was examined on six tumor cell lines (HeLa, A549, K562, MDA-MB-453, MDA-MB-361 and LS-174) and two normal cell line (MRC-5 and BEAS-2B). All the investigated nickel(II) complexes were cytotoxic against all tumor cell lines. The newly synthesized azido complex showed selectivity to HeLa and A549 tumor cell lines compared to the normal cells (for A549 IC50 was similar to that of cisplatin). Azido complex interferes with cell cycle phase distribution of A549 and HeLa cells and possesses nuclease activity towards supercoiled DNA. The observed selectivity of the azido complex for some tumor cell lines can be connected with its strong DNA damaging activity.
['Čobeljić|Božidar|B|', 'Milenković|Milica|M|', 'Pevec|Andrej|A|', 'Turel|Iztok|I|', 'Vujčić|Miroslava|M|', 'Janović|Barbara|B|', 'Gligorijević|Nevenka|N|', 'Sladić|Dušan|D|', 'Radulović|Siniša|S|', 'Jovanović|Katarina|K|', 'Anđelković|Katarina|K|']
D000970:Antineoplastic Agents D001547:Benzaldehydes D018360:Crystallography, X-Ray D006219:Halogens D006367:HeLa Cells D006801:Humans D006835:Hydrazones D008856:Microscopy, Fluorescence D009532:Nickel D013050:Spectrometry, Fluorescence D013055:Spectrophotometry, Infrared D013056:Spectrophotometry, Ultraviolet
Cytotoxicity Nickel(II) complexes DNA interactions Girard’s T reagent Phosphine ligands