Asian consensus on the relationship between obesity and gastrointestinal and liver diseases.
The incidence of obesity is increasing in Asia, with implications on gastrointestinal (GI) and liver diseases. The Gut and Obesity in Asia Workgroup comprises regional experts with the aim of studying relationship between obesity and the GI and liver diseases in Asia. Through literature review and the modified Delphi process, consensus statements examining the impact of obesity on esophageal, gastric, pancreatic, colorectal, and liver diseases, exploring relationship between gut microbiome and obesity, and assessing obesity therapies have been produced by the Gut and Obesity in Asia Workgroup. Sixteen experts participated with 9/15 statements having strong consensus (>80% agreement). The prevalence of obesity in Asia is increasing (100% percentage agreement in brackets), and this increased prevalence of obesity will result in a greater burden of obesity-related GI and liver diseases (93.8%). There was consensus that obesity increases the risk of gastric cancer (75%) and colorectal neoplasia (87.5%). Obesity was also associated with Barrett's esophagus and esophageal adenocarcinoma (66.7%) and pancreatic cancer (66.7%) in Asia. The prevalence of non-alcoholic fatty liver disease (NAFLD) in Asia is on the rise (100%), and the risk of NAFLD in Asia (100%) is increased by obesity. Obesity is a risk factor for the development of hepatocellular carcinoma (93.8%). Regarding therapy, it was agreed that bariatric surgery was an effective treatment modality for obesity (93.8%) but there was less agreement on its benefit for NAFLD (62.5%). These experts' consensus on obesity and GI diseases in Asia forms the basis for further research, and its translation into addressing this emerging issue.
['Koh|Jianyi Calvin|JC|', 'Loo|Wai Mun|WM|', 'Goh|Khean Lee|KL|', 'Sugano|Kentaro|K|', 'Chan|Wah Kheong|WK|', 'Chiu|Wai Yan Philip|WY|', 'Choi|Myung-Gyu|MG|', 'Gonlachanvit|Sutep|S|', 'Lee|Wei-Jei|WJ|http://orcid.org/0000-0002-6486-7717', 'Lee|Wei Jie Jonathan|WJ|', 'Lee|Yeong Yeh|YY|', 'Lesmana|Laurentius A|LA|', 'Li|You-Ming|YM|', 'Liu|Chun Jen|CJ|', 'Matsuura|Bunzo|B|', 'Nakajima|Atsushi|A|', 'Ng|Enders Kwok Wai|EK|', 'Sollano|Jose D|JD|', 'Wong|Simon Kin Hung|SK|', 'Wong|Vincent W S|VW|', 'Yang|Yunsheng|Y|', 'Ho|Khek Yu|KY|', 'Dan|Yock Young|YY|']
D001208:Asia D044466:Asians D032921:Consensus D003697:Delphi Technique D019317:Evidence-Based Medicine D005767:Gastrointestinal Diseases D000069196:Gastrointestinal Microbiome D041981:Gastrointestinal Tract D006801:Humans D015994:Incidence D008107:Liver Diseases D009765:Obesity D015995:Prevalence D011379:Prognosis D018570:Risk Assessment D012307:Risk Factors
Barrett's esophagus pancreatic cancer NAFLD hepatocellular carcinoma carcinogenesis and metastasis clinical esophageal neoplasms gastric cancer: epidemiology and surveillance microbial pathogenesis