The influence of mechanical bowel preparation on long-term survival in patients surgically treated for colorectal cancer.
BACKGROUND
In this study, we evaluated long-term survival in patients treated with and without mechanical bowel preparation (MBP) before colorectal surgery for cancer.


METHODS
Long-term outcome of patients of 2 main participating hospitals in a prior multicenter randomized trial comparing clinical outcome of MBP versus no MBP was reviewed. Primary endpoint was cancer-related mortality and secondary endpoint was all-cause mortality.


RESULTS
A total of 382 patients underwent potentially curative surgery for colorectal cancer. One hundred seventy-seven (46%) patients were treated with MBP and 205 (54%) were not before surgery. Median follow-up was 7.6 years (mean 6.6, range .01 to 12.73). There was no significant difference in both cancer-related mortality and all-cause mortality in patients treated with MBP and without MBP (P = .76 and P = .36, respectively). Multivariate analysis, taking account of age, sex, AJCC cancer stage, and ASA classification, also showed no survival difference.


CONCLUSIONS
Our results indicate that MBP does not seem to influence long-term survival in patients surgically treated for colorectal cancer.
["van't Sant|Hans Pieter|HP|", 'Kamman|Arnoud|A|', 'Hop|Wim C J|WC|', 'van der Heijden|Martijn|M|', 'Lange|Johan F|JF|', 'Contant|Caroline M E|CM|']
D000368:Aged D002400:Cathartics D015179:Colorectal Neoplasms D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D011300:Preoperative Care D012189:Retrospective Studies D015996:Survival Rate D013997:Time Factors
Survival Colorectal cancer Surgery