Synthesis of L-Lys-Aminoxy-Goralatide.
Natural tetrapeptide Goralatide inhibits primitive hematopoietic cell proliferation but reported to be rather unstable in solution (half-life 4.5 min). In this work, we report the synthesis of an aminoxy analog of Goralatide. Aminoxy moiety is expected to provide increased stability and bioavailability of the Goralatide analog.
['Li|Zhiliang|Z|', 'Lebedyeva|Iryna|I|', 'Zhao|Deqian|D|', 'Myers|Lauren|L|', 'Pillai|Girinath G|GG|', 'Hall|Charles Dennis|CD|', 'Katritzky|Alan R|AR|']
D009682:Magnetic Resonance Spectroscopy D009842:Oligopeptides D010455:Peptides
Goralatide acylation coupling peptides peptidomimetics