Activated Ductal Proliferation Induced by N-Nitrosobis (2-oxopropyl)amine in Fat-infiltrated Pancreas of KK-A Mice.
BACKGROUND/AIM
Our aim was to investigate whether tissue with fatty infiltration within the lobes of the pancreas (scattered FI) is sensitive to carcinogen-induced pancreatic ductal proliferation.


MATERIALS AND METHODS
Seven-week-old female C57BL/6J, C57BL/6J-Ay, KK-Ay, and ICR mice were subcutaneously treated with N-nitrosobis(2-oxopropyl) amine at a dose of 80 mg/kg body weight, and the differences in damage-induced cell proliferation and their biochemical data were compared 2 days after.


RESULTS
Scattered FI in the pancreas was obvious only in KK-Ay mice, which have high serum lipid, leptin and insulin levels, and cell proliferation both in pancreatic and common bile ducts was enhanced only in KK-Ay mice by the carcinogen treatment.


CONCLUSION
Scattered FI in the pancreas per se can be an important factor for carcinogenesis. The genetic background causing scattered FI of the pancreas should be further investigated.
['Hori|Mika|M|', 'Mutoh|Michihiro|M|', 'Ishigamori|Rikako|R|', 'Imai|Toshio|T|', 'Takahashi|Mami|M|']
D000818:Animals D015415:Biomarkers D002273:Carcinogens D049109:Cell Proliferation D002471:Cell Transformation, Neoplastic D006224:Cricetinae D004195:Disease Models, Animal D005260:Female D007150:Immunohistochemistry D051379:Mice D009602:Nitrosamines D010179:Pancreas D010183:Pancreatic Ducts D010190:Pancreatic Neoplasms
proliferation Fatty infiltration mouse pancreatic cancer type 2 diabetes mellitus