Ruxolitinib for the treatment of graft-versus-host disease.
Introduction: Ruxolitinib is an oral selective JAK1/JAK2 inhibitor, initially approved by the FDA for the treatment of intermediate-2 or high-risk myelofibrosis and patients with polycythemia vera who have had an inadequate response or are intolerant to hydroxyurea.Areas covered: Accumulating evidence supports the role of JAK1/JAK2 pathways in the pathogenesis of graft-versus-host disease (GVHD), and preclinical studies have demonstrated promising efficacy of ruxolitinib in treatment/prevention of GVHD. Early clinical observations that ruxolitinib was effective in treatment of steroid-refractory (SR) acute and chronic GVHD led to the development of prospective clinical trials; Phase II REACH1 (NCT02953678), Phase III REACH2 (NCT02913261), and REACH3 (NCT03112603). Based on the data from the REACH1 trial, ruxolitinib was approved by the FDA in May 2019 for SR acute GVHD in adult and pediatric patients 12 years and older.Expert opinion: Ruxolitinib and other JAK1/JAK2 inhibitors hold promise in other treatment settings such as GVHD prevention and/or first-line therapy.
['Ali|Haris|H|', 'Salhotra|Amandeep|A|', 'Modi|Badri|B|', 'Nakamura|Ryotaro|R|']
D000818:Animals D002986:Clinical Trials as Topic D006086:Graft vs Host Disease D006801:Humans D053613:Janus Kinase 1 D053614:Janus Kinase 2 D009570:Nitriles D011720:Pyrazoles D011743:Pyrimidines D015398:Signal Transduction D014481:United States D014486:United States Food and Drug Administration
ruxolitinib graft-versus-host disease (GVHD) Allogeneic hematopoietic stem cell transplantation JAK inhibitor