Evaluation of store lesion in platelet obtained by apheresis compared to platelet derived from whole blood and its impact on the in vitro functionality.
Platelet units for transfusion purposes are obtained manually from whole blood or by apheresis, in an automated process. In both methods, platelets during storage present a characteristics grouped under the name "storage lesion" that are associated with adverse effects on platelet units. Oxidative stress has been claimed to be one of major causes, leading to activation and apoptosis processes affecting their post transfusion functionality. In this work, we observed an association between apheresis and a reduced presence of oxidative stress and better results in functional markers in stored platelets, compared to manually obtained platelets. Then, apheresis which would ensure a greater number of functional platelets during the 5 days of storage, compared to concentrates obtained from whole blood.
['Quintero|M|M|', 'Núñez|M|M|', 'Mellado|S|S|', 'Maldonado|M|M|', 'Wehinger|S|S|']
D000328:Adult D001792:Blood Platelets D001793:Blood Preservation D005260:Female D006801:Humans D008297:Male D018384:Oxidative Stress D015539:Platelet Activation D017713:Platelet Transfusion D010983:Plateletpheresis D013997:Time Factors
Platelet Storage lesion Oxidative stress Platelet activation Platelet apheresis