Calcium and vitamin D supplementation do not influence menopause-related symptoms: Results of the Women's Health Initiative Trial.
BACKGROUND
It is unknown whether supplementation with calcium and vitamin D has an impact on menopause-related symptoms.


METHODS
As part of the Women's Health Initiative Calcium/Vitamin D Supplementation Trial (CaD), women were randomized at 40 clinical sites to elemental calcium carbonate 1000 mg with vitamin D 400 IU daily or placebo. At the CaD baseline visit (year 1 or year 2) and during a mean follow-up of 5.7 years, participants provided data on menopause-related symptoms via questionnaires. Generalized linear mixed effects techniques were used to address research questions.


RESULTS
After excluding participants with missing data (N=2125), we compared menopause-related symptoms at follow-up visits of 17,101 women randomized to CaD with those of 17,056 women given the placebo. Women in the CaD arm did not have a different number of symptoms at follow-up compared to women taking the placebo (p=0.702). Similarly, there was no difference between sleep disturbance, emotional well-being, or energy/fatigue at follow-up in those who were randomized to CaD supplementation compared to those taking the placebo.


CONCLUSIONS
Our data suggest that supplementation with 1000 mg of calcium plus 400 IU of vitamin D does not influence menopause-related symptoms over an average of 5.7 years of follow-up among postmenopausal women with an average age of 64 at the WHI baseline visit.
['LeBlanc|Erin S|ES|', 'Hedlin|Haley|H|', 'Qin|FeiFei|F|', 'Desai|Manisha|M|', 'Wactawski-Wende|Jean|J|', 'Perrin|Nancy|N|', 'Manson|JoAnn E|JE|', 'Johnson|Karen C|KC|', 'Masaki|Kamal|K|', 'Tylavsky|Frances A|FA|', 'Stefanick|Marcia L|ML|']
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Calcium Vitamin D Sleep Hot flashes Menopause Mood