Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients
Background/aim
The aim of our study was to compare Tc-99m MDP bone scan and Ga-68 PSMA PET/CT in terms of detection of bone metastasis in prostate cancer patients.


Materials  and  methods
A  total  of  28  prostate  cancer  patients  with  bone  scan  and  PSMA  PET/CT  performed  within  90  days  were  retrospectively included in our analysis. All bone lesions were scored as negative (score-0), positive (score-1), or suspicious (score-2) for metastasis by two experienced nuclear medicine physicians. Both patient-based and region-based analyses were made for all osseous lesions.


Results
On per-patient analysis; sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were  72.7%,  52.9%,  50%,  75%,  and  60.7%,  respectively,  for  bone  scan  and  90.9%,  100%,  100%,  94.4%,  and  96.4%,  respectively,  for  PSMA PET/CT. On per-region analysis; sensitivity, specificity, PPV, NPV, and accuracy were 76.2%, 80.9%, 57.1%, 91.1%, and 79.8%, respectively, for bone scan and 85.7%, 100%, 100%, 95.5%, and 95.4%, respectively, for PSMA PET/CT.


Conclusion
Ga-68 PSMA PET/CT has higher sensitivity, specificity, and accuracy compared to bone scan in terms of bone metastasis detection in prostate cancer patients. Therefore, it might be the modality of choice for patients with suspicion for metastatic disease, despite negative bone scan and conventional imaging results
['Uslu-Beşli|Lebriz|L|0000-0003-1868-3957', 'Sağer|Sait|S|0000-0003-2013-5845', 'Akgün|Elife|E|0000-0001-5625-9749', 'Asa|Sertaç|S|0000-0003-4060-9331', 'Şahin|Onur Erdem|OE|0000-0003-2330-8078', 'Demirdağ|Çetin|Ç|0000-0002-8912-9155', 'Güner|Ekrem|E|0000-0002-4770-7535', 'Khosroshahi|Baresh Razavi|BR|0000-0002-6272-4384', 'Karayel|Emre|E|0000-0001-8114-2315', 'Pehlivanoğlu|Hüseyin|H|0000-0003-4833-0976', 'Aygün|Aslan|A|0000-0001-7094-1699', 'Uslu|İlhami|İ|0000-0002-5981-5760', 'Talat|Zübeyr|Z|0000-0002-0507-6552', 'Sönmezoğlu|Kerim|K|0000-0003-1215-5184']
D000368:Aged D001859:Bone Neoplasms D001842:Bone and Bones D005710:Gallium Radioisotopes D006801:Humans D008297:Male D008875:Middle Aged D000072078:Positron Emission Tomography Computed Tomography D011237:Predictive Value of Tests D011471:Prostatic Neoplasms D019275:Radiopharmaceuticals D012189:Retrospective Studies D012680:Sensitivity and Specificity D013669:Technetium Tc 99m Medronate
Ga-68 PSMA prostate cancer PET/CT bone metastasis bone scintigraphy