Cerebrolysin reduces mechanical allodynia in a rodent model of peripheral inflammation.
Cerebrolysin (Cbl) is a neuropeptide preparation of cerebroproteins that crosses the blood brain barrier displaying neuroprotective properties and promoting neurogenesis. Limited evidence exists on the efficacy of Cbl for the treatment of pain, with many studies focusing on neuropathic pain associated to diabetes. Therefore, we designed a study to test the hypothesis that Cbl would reduce mechanical allodynia in a rat model of peripheral inflammation induced by administration of complete Freund's adjuvant (CFA) in the hind paw. We found that acute administration of Cbl was effective in reducing mechanical allodynia but not peripheral inflammation in the CFA model of inflammatory pain. Our investigation supports further investigation into the therapeutic applications and mechanisms underlying the anti-allodynic effects of Cbl in inflammatory pain.
['Morales-Medina|Julio Cesar|JC|', 'Griffiths|Natalie H|NH|', 'Flores|Gonzalo|G|', 'Mastranzo|Virginia M|VM|', 'Iannitti|Tommaso|T|']
D000596:Amino Acids D000818:Animals D004195:Disease Models, Animal D006930:Hyperalgesia D007249:Inflammation D008297:Male D009474:Neurons D018696:Neuroprotective Agents D017288:Pain Threshold D051381:Rats D017208:Rats, Wistar
Cerebrolysin Allodynia Peripheral inflammation Complete Freund’s adjuvant