Selective serotonin reuptake inhibitors and dental implant failure-A significant concern in elders?
OBJECTIVE
Depression is a significantly prevalent health concern in geriatric populations. Selective serotonin reuptake inhibitor drugs (SSRI) are the most commonly prescribed antidepressant agents, with increasing rates of prescription. The present report aimed to present a concise review of the current understanding regarding SSRI effects on bone and dental implant outcomes.


MATERIALS AND METHODS
A broad-based review and summary of literature pertaining to the effects of SSRI on bone metabolism and on dental implant survival was performed.


RESULTS
The available literature indicates that serotonin plays a significant role in bone metabolism and experimental reports demonstrate adverse impacts of SSRI on multiple pathways of bone metabolism. Early clinical reports suggest detrimental effects of SSRI on dental implant survival. The type of SSRI drug, dosage and host-related genetic and metabolic factors could be potential modulating factors. There is a paucity of data regarding SSRI usage and dental implant survival specific to geriatric cohorts.


CONCLUSION
As older individuals comprise a high-risk group for both high oral rehabilitation and SSRI use, clinicians should be aware the potential association between SSRI and dental implant failures. Well-designed investigations specific to geriatric cohorts are essential to understand the implications of SSRI use on dental implant prognosis.
['Gupta|Bhumija|B|', 'Acharya|Aneesha|A|http://orcid.org/0000-0002-9319-6780', 'Pelekos|Georgios|G|', 'Gopalakrishnan|Dharmarajan|D|', 'Kolokythas|Antonia|A|']
D000368:Aged D000928:Antidepressive Agents D001842:Bone and Bones D015921:Dental Implants D019232:Dental Restoration Failure D006801:Humans D017367:Serotonin Uptake Inhibitors
dental implants selective serotonin reuptake inhibitor drugs bone ageing