Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein expression predicts disease severity in chronic hepatitis C patients.
Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) has recently been developed as a promising liver fibrosis glyco biomarker. We assessed its efficacy in evaluating liver disease severity in chronic hepatitis C (CHC) in Taiwan. The association between WFA+-M2BP and histological features was evaluated among those CHC patients underwent liver biopsy. We also aimed to clarify the factors determining the performance of WFA+-M2BP in CHC. A total of 229 CHC patients were consecutively recruited. The mean value of WFA+-M2BP in patients from F0 to F4 was 1.68, 2.23, 3.45, 3.48, 3.77 respectively (linear trend P = 0.008). Linear regression analysis revealed that alanine aminotransferase (odds ratio [OR]: 0.03, 95% confidence intervals [CI]: 0.02-0.05, P < 0.001), AST (OR: -0.1, 95% CI: -0.02 to -0.01, P < 0.001), and liver fibrosis (OR: 0.30, 95% CI: 0.01-0.59, P = 0.043) were the independent factors correlated to serum WFA+-M2BP level. The optimal cutoff values of WFA+-M2BP for fibrosis stages F1, F2, F3, and F4 were 1.42, 1.61, 1.42, and 2.67, respectively. Multivariate analysis revealed that the platelet count (OR/CI: -0.009/0.986-0.996, P = <0.001), r-glutamyl transferase (OR/CI: 0.007/1.000-1.013, P = 0.036), and WFA+-M2BP (OR/CI: 0.187/1.057-1.374, P = 0.005). We concluded that WFA+-M2BP is a competent noninvasive marker for liver fibrosis assessment in CHC patients.
['Huang|Ching-I|CI|', 'Huang|Chung-Feng|CF|', 'Yeh|Ming-Lun|ML|', 'Lin|Yi-Hung|YH|', 'Liang|Po-Cheng|PC|', 'Hsieh|Meng-Hsuan|MH|', 'Dai|Chia-Yen|CY|', 'Hsieh|Ming-Yen|MY|', 'Lin|Zu-Yau|ZY|', 'Chen|Shinn-Cherng|SC|', 'Huang|Jee-Fu|JF|', 'Yu|Ming-Lung|ML|', 'Chuang|Wan-Long|WL|']
D000293:Adolescent D000328:Adult D000368:Aged D000410:Alanine Transaminase D000951:Antigens, Neoplasm D015415:Biomarkers D005260:Female D015870:Gene Expression D016174:Hepacivirus D019698:Hepatitis C, Chronic D006801:Humans D016014:Linear Models D008099:Liver D008103:Liver Cirrhosis D008297:Male D008562:Membrane Glycoproteins D008875:Middle Aged D037121:Plant Lectins D010976:Platelet Count D011379:Prognosis D011485:Protein Binding D034781:Receptors, N-Acetylglucosamine D012680:Sensitivity and Specificity D012720:Severity of Illness Index D005722:gamma-Glutamylcyclotransferase
Liver fibrosis Hepatitis C virus M2BP