Identification of chronic kidney disease risk in relatively lean Southern Chinese: the hypertriglyceridemic waist phenotype vs. anthropometric indexes.
PURPOSE
Assessing and comparing the ability of the hypertriglyceridemic waist (HW) phenotype and anthropometric obesity indexes to identify subjects at high risk of chronic kidney disease (CKD) in a relatively lean population in South China.


METHODS
Using data from a community-based, cross-sectional study conducted in Zhuhai City, Southern China, we examined associations between the HW phenotype, anthropometric obesity indexes, and incident CKD risk in a relatively lean population. Multiple logistic regression analyses were used to evaluate the associations.


RESULTS
The HW phenotype associated with CKD significantly in the unadjusted analysis (OR 3.53, 95% CI 1.65-7.52, P = 0.001). Further adjustment for gender, age, and other potential confounding variables had an impact on the odd ratios (OR); the OR decreased but still existed (OR 2.91, 95% 1.23-6.87, P = 0.016). The association of the HW phenotype with CKD remained significant after further adjustment for hypertension and diabetes. No significant association between the anthropometric indexes and incident CKD was found.


CONCLUSION
The HW phenotype, but not the anthropometric indexes, is associated with an elevated risk of CKD in relatively lean subjects. The HW phenotype appears to be a better predictor of CKD than the anthropometric indexes.


LEVEL OF EVIDENCE
Level V, descriptive study.
['Zhou|Chaomin|C|http://orcid.org/0000-0002-0817-4078', 'Li|Yongqiang|Y|', 'Shao|Xiaofei|X|', 'Zou|Hequn|H|']
D000328:Adult D000368:Aged D000886:Anthropometry D002681:China D003430:Cross-Sectional Studies D005260:Female D006801:Humans D064250:Hypertriglyceridemic Waist D008297:Male D008875:Middle Aged D010641:Phenotype D051436:Renal Insufficiency, Chronic D012307:Risk Factors D055105:Waist Circumference
Chronic kidney disease Hypertriglyceridemic waist phenotype Anthropometric indexes Visceral adiposity