Subjective quality of life in first-episode psychosis. A ten year follow-up study.
UNLABELLED
Subjective quality of life (S-QoL) is an important outcome measure in first episode psychosis (FEP). The aims of this study were to describe S-QoL-development the first 10-years in FEP patients and to identify predictors of this development.


METHODS
A representative sample of 272 patients with a first episode psychotic disorder was included from 1997 through 2000. At 10 year follow-up 186 patients participated. QoL was measured by the Lehman's Quality of Life Interview. Linear mixed model analyses were performed to investigate longitudinal effects of baseline psychiatric symptoms and socio-economic variables and the effects of changes in the same variables on S-QoL-development.


RESULTS
S-QoL improved significantly over the follow-up period. More contact with family and a better financial situation at baseline had a positive and longstanding effect on S-QoL-development, but changes in these variables were not associated with S-QoL-development. Higher depressive symptoms and less daily activities at baseline both had a negative independent effect, but a positive interaction effect with time on S-QoL-development indicating that the independent negative effect diminished over time. In the change analysis, increased daily activities and a decrease in depressive symptoms were associated with a positive S-QoL-development.


CONCLUSIONS
Treatment of depressive symptoms and measures aimed at increasing daily activities seem important to improve S-QoL in patients with psychosis. More contact with family and a better financial situation at baseline have a long-standing effect on S-QoL-development in FEP patients.
['Gardsjord|Erlend Strand|ES|', 'Romm|Kristin Lie|KL|', 'Friis|Svein|S|', 'Barder|Helene Eidsmo|HE|', 'Evensen|Julie|J|', 'Haahr|Ulrik|U|', 'ten Velden Hegelstad|Wenche|W|', 'Joa|Inge|I|', 'Johannessen|Jan Olav|JO|', 'Langeveld|Johannes|J|', 'Larsen|Tor Ketil|TK|', 'Opjordsmoen|Stein|S|', 'Rund|Bjørn Rishovd|BR|', 'Simonsen|Erik|E|', 'Vaglum|Per|P|', 'McGlashan|Thomas|T|', 'Melle|Ingrid|I|', 'Røssberg|Jan Ivar|JI|']
D000208:Acute Disease D000328:Adult D003863:Depression D005260:Female D005500:Follow-Up Studies D006801:Humans D016014:Linear Models D008137:Longitudinal Studies D008297:Male D011446:Prospective Studies D011569:Psychiatric Status Rating Scales D011618:Psychotic Disorders D011788:Quality of Life D012559:Schizophrenia D012565:Schizophrenic Psychology
Quality of life First-episode psychosis Follow-up Affective psychosis Schizophrenia