Particulate matter exposure and biomarkers associated with blood coagulation: A meta-analysis.
OBJECTIVE
Find the correlation between particulate matter (PM) and biomarkers related to blood coagulation, offer medical evidence to sensitive indicators and carry out early diagnosis of cardiovascular diseases.


METHOD
A combination of computer and manual retrieval was used to search for the keywords in PubMed (584 records), Cochrane Library (28 records), Web of Science (162 records) and Embase (163 records). Finally, a total of 25 articles were included in this meta-analysis. Stata 13.0 was applied to examine the heterogeneity among the studies and to calculate the combined effect estimates, percent variation (%) and 95% CI by selecting corresponding models. Additionally, sensitivity analysis and publication bias test were also conducted.


RESULTS
Meta-analysis indicated that there was an association between PM2.5 exposure (per 10 µg/m3 increase) and fibrinogen. With the increase of PM2.5 exposure (per 10 µg/m3 increase), the content of fibrinogen revealed a high level (2.26%; 95% CI: 1.08-3.44%); and the increase of UFPs exposure (per 5000/cm3 increase) was correlated with some biomarkers such as cell surface antigen and protein ligand including ICAM-1, sCD40L, P-selectin, E-selectin and PAI-1 that indirectly related to blood coagulation, yielding a percent variation of 10.83% (95% CI: 3.49%-18.17%).


CONCLUSION
This meta-analysis expounded that PM-related biomarkers were associated with blood coagulation, and the relationship with fibrinogen was much stronger.
['Sun|Mengqi|M|', 'Liang|Qingqing|Q|', 'Ma|Yuexiao|Y|', 'Wang|Fenghong|F|', 'Lin|Lisen|L|', 'Li|Tianyu|T|', 'Sun|Zhiwei|Z|', 'Duan|Junchao|J|']
D000393:Air Pollutants D015415:Biomarkers D001777:Blood Coagulation D005340:Fibrinogen D006801:Humans D019570:Inhalation Exposure D010316:Particle Size D052638:Particulate Matter
Particulate matter Biomarker Blood coagulation Fibrinogen Air pollution