Facile Total Synthesis of (+)-Spinoxazine B.
Herein we describe a short total synthesis of (+)-spinoxazine B, which inhibits nitric oxide (NO) production in BV-2 microgrial cells. Spinoxazine B is the first example of a natural alkaloid containing an oxazinone-pyrrolidone nucleus, and it is expected to serve as a novel drug lead compound as well as a drug discovery scaffold.
['Iwata|Mayuko|M|', 'Kuwabara|Motoi|M|', 'Matsuzawa|Akinobu|A|', 'Sugita|Kazuyuki|K|']
D000818:Animals D002461:Cell Line, Transformed D051379:Mice D008968:Molecular Conformation D009569:Nitric Oxide D010078:Oxazines D013237:Stereoisomerism
total synthesis spinoxazine B 1,3-oxazine-6-one salinazinone B