Prevalence of restless legs syndrome in patients with irritable bowel syndrome.
AIM
To determine the prevalence of restless legs syndrome (RLS) in patients with irritable bowel syndrome (IBS).


METHODS
Patients with diarrhea-predominant IBS (n = 30), constipation-predominant IBS (n = 30), or mixed-symptom IBS (n = 30) were recruited from the community between March 2008 and February 2009. Rifaximin 200 mg three times daily was administered empirically to alleviate small intestinal bowel overgrowth in all patients. The presence of RLS was assessed via an RLS questionnaire and polysomnography.


RESULTS
Twenty-six patients with IBS (29%) were diagnosed with RLS using the RLS questionnaire. Twenty-four of the 26 patients (92%) underwent polysomnography, and all had confirmation of RLS. A greater percentage of patients with RLS had diarrhea-predominant IBS (62%) compared with patients with constipation-predominant IBS (4%) or mixed-symptom IBS (33%).


CONCLUSION
Restless legs syndrome is prevalent in patients with IBS, especially those with diarrheal symptoms. Assessment of concomitant disorders may improve diagnosis and expand relevant treatment options for patients.
['Basu|P Patrick|PP|', 'Shah|N James|NJ|', 'Krishnaswamy|Nithya|N|', 'Pacana|Tommy|T|']
D000328:Adult D015897:Comorbidity D003967:Diarrhea D005260:Female D006801:Humans D043183:Irritable Bowel Syndrome D008297:Male D008875:Middle Aged D017286:Polysomnography D012148:Restless Legs Syndrome D011795:Surveys and Questionnaires D055815:Young Adult
Prevalence Restless legs syndrome Irritable bowel syndrome Small intestinal bacterial overgrowth