Data on amyloid precursor protein accumulation, spontaneous physical activity, and motor learning after traumatic brain injury in the triple-transgenic mouse model of Alzheimer׳s disease.
This data article contains supporting information regarding the research article entitled "Traumatic brain injury accelerates amyloid-β deposition and impairs spatial learning in the triple-transgenic mouse model of Alzheimer׳s disease" (H. Shishido, Y. Kishimoto, N. Kawai, Y. Toyota, M. Ueno, T. Kubota, Y. Kirino, T. Tamiya, 2016) [1]. Triple-transgenic (3×Tg)-Alzheimer׳s disease (AD) model mice exhibited significantly poorer spatial learning than sham-treated 3×Tg-AD mice 28 days after traumatic brain injury (TBI). Correspondingly, amyloid-β (Aβ) deposition within the hippocampus was significantly greater in 3×Tg-AD mice 28 days after TBI. However, data regarding the short-term and long-term influences of TBI on amyloid precursor protein (APP) accumulation in AD model mice remain limited. Furthermore, there is little data showing whether physical activity and motor learning are affected by TBI in AD model mice. Here, we provide immunocytochemistry data confirming that TBI induces significant increases in APP accumulation in 3×Tg-AD mice at both 7 days and 28 days after TBI. Furthermore, 3×Tg-AD model mice exhibit a reduced ability to acquire conditioned responses (CRs) during delay eyeblink conditioning compared to sham-treated 3×Tg-AD model mice 28 days after TBI. However, physical activity and motor performance are not significantly changed in TBI-treated 3×Tg-AD model mice.
['Kishimoto|Yasushi|Y|', 'Shishido|Hajime|H|', 'Sawanishi|Mayumi|M|', 'Toyota|Yasunori|Y|', 'Ueno|Masaki|M|', 'Kubota|Takashi|T|', 'Kirino|Yutaka|Y|', 'Tamiya|Takashi|T|', 'Kawai|Nobuyuki|N|']
Amyloid precursor protein Spontaneous physical activity Traumatic brain injury Eyeblink conditioning AD, Alzheimer׳s disease ANOVA, analysis of variance APP, amyloid precursor protein CR, conditioned response CS, conditioned stimulus Rotarod test TBI, traumatic brain injury US, unconditioned stimulus