Symptomatic lower-limb giant-cell arteritis: Characteristics, management and long-term outcome.
OBJECTIVE
To describe characteristics and long-term outcomes of the rare symptomatic lower-limb giant-cell arteritis (LL-GCA).


METHODS
Retrospective analysis of 8 patients (6 women; mean±SD age, 63.6±10.9 years; follow-up, 137.3±57.3 months).


RESULTS
Four patients satisfied≥3 American College of Rheumatology (ACR) GCA-classification criteria; 4 had<3 criteria and histological LL-GCA proof or associated typical upper-limb involvement. Patients had 2.1±1.1 vascular risk factors. Bilateral and rapidly progressive arterial claudication was the first LL sign; 2 had rest ischemia. Imaging-visualized most-to-least frequent inflammatory lesion localizations were: superficial femoral, popliteal, tibiofibular trunk, posterior tibial arteries. All received corticosteroids for 132±76.2 months; 2 required immunosuppressive agent adjunction. Only 3 required 1-6 revascularizations: twice during the first month post-diagnosis and twice later. Thromboendarterectomy and endovascular procedures did not work while bypasses were successful. LL-claudication regressed for 7 (10.5±12.1 months) and disappeared for 5 (16.8±9.8 months). Three patients stopped corticosteroids (26-90 months), 1 restarted 45 months later. Every patient relapsed once (23.9±26.7 months, mean corticosteroid dose: 0.28±0.30mg/kg/day). LL-GCA caused only 1 of the 4 deaths.


CONCLUSION
Symptomatic LL-GCA attributable long-term mortality seems to be low despite frequent relapses and corticosteroid-dependence.
['Le Hello|C|C|', 'Auboire|L|L|', 'Berger|L|L|', 'Gouicem|D|D|', 'Barrellier|M T|MT|', 'Duthois|S|S|']
D000328:Adult D000368:Aged D005260:Female D013700:Giant Cell Arteritis D006801:Humans D035002:Lower Extremity D008297:Male D008875:Middle Aged D012189:Retrospective Studies D013997:Time Factors D016896:Treatment Outcome
Giant-cell arteritis Outcome Revascularization Artérite des membres inférieurs Maladie de Horton Medical management Peripheral arterial disease Revascularisation Résultats Traitement médical