A new glucoside with a potent α-glucosidase inhibitory activity from Lycium schweinfurthii.
A new glucoside, 3-methoxy-4-O-β-D-glucopyranosyl-methyl benzoate, has been isolated from Lycium schweinfurthii along with five known compounds through bioactivity guided fractionation of the total plant methanolic extract towards α-glucosidase inhibitory activity. All the isolated compounds were tested for their inhibitory effect on α-glucosidase enzyme. As a result, four of them showed a potent inhibitory activity and thus constitute a therapeutic approach to decrease postprandial hyperglycemia in diabetic patients.
['Elbermawi|Ahmed|A|', 'Halim|Ahmed F|AF|', 'Mansour|El-Sayed S|ES|', 'Ahmad|Kadria F|KF|', 'Ashour|Ahmed|A|', 'Amen|Yhiya|Y|', 'Shimizu|Kuniyoshi|K|http://orcid.org/0000-0001-5960-1503']
D020001:1-Butanol D000085:Acetates D005591:Chemical Fractionation D003920:Diabetes Mellitus D005960:Glucosides D065089:Glycoside Hydrolase Inhibitors D006801:Humans D032305:Lycium D000432:Methanol D010936:Plant Extracts D000520:alpha-Glucosidases
α-glucosidase Lycium hyperglycemia