Carbon nanotubes as vaccine scaffolds.
Carbon nanotubes display characteristics that are potentially useful in their development as scaffolds for vaccine compositions. These features include stability in vivo, lack of intrinsic immunogenicity, low toxicity, and the ability to be appended with multiple copies of antigens. In addition, the particulate nature of carbon nanotubes and their unusual properties of rapid entry into antigen-presenting cells, such as dendritic cells, make them especially useful as carriers of antigens. Early attempts demonstrating carbon nanotube-based vaccines can be used in both infectious disease settings and cancer are promising.
['Scheinberg|David A|DA|', 'McDevitt|Michael R|MR|', 'Dao|Tao|T|', 'Mulvey|J Justin|JJ|', 'Feinberg|Evan|E|', 'Alidori|Simone|S|']
D000818:Animals D000938:Antigen-Presenting Cells D000941:Antigens D003141:Communicable Diseases D003713:Dendritic Cells D006801:Humans D037742:Nanotubes, Carbon D009369:Neoplasms D014612:Vaccines
Carbon nanotubes vaccines adjuvants antigen presenting cells