Interkingdom Genetic Mix-and-Match To Produce Novel Sunscreens.
Sunscreen-containing skincare products protect the skin from damage caused by sun exposure. However, many of them contain oxybenzone and/or octinoxate, which have been reported to be toxic to juvenile coral and to cause coral bleaching. Thus, there is a growing need for new sunscreen compounds that are less harmful to the environment. Here, we report an engineered biosynthetic pathway employing genes from a vertebrate and two Gram-(+) bacteria that forms novel sunscreen compounds with hybrid structures of gadusol and mycosporine-like amino acids, both of which are found in marine environments. These compounds, named gadusporines, have unique UV absorbance at 340 nm, expanding the range of mycosporine- and gadusol-based sunscreen products. The synthesis of gadusporines in Streptomyces coelicolor establishes a platform for the design and production of novel sunscreens.
['Osborn|Andrew R|AR|0000-0001-9823-4929', 'Mahmud|Taifo|T|0000-0001-9639-526X']
D000596:Amino Acids D000818:Animals D037421:Anthozoa D001577:Benzophenones D002934:Cinnamates D003511:Cyclohexanols D060847:Metabolic Engineering D010957:Plasmids D012240:Rhodococcus D063465:Skin Cream D013302:Streptomyces D048372:Streptomyces coelicolor D013473:Sunscreening Agents D014466:Ultraviolet Rays D015027:Zebrafish
sunscreen gadusol mycosporine-like amino acid gadusporine Streptomyces Rhodococcus zebra fish