Emperor's new clothes: Is particle disease really infected particle disease?
Aseptic loosening remains the most significant long-term complication of total hip replacement. The current paradigm points to an inflammatory response to wear particles as its main trigger. Recently, there have been increasing numbers of positive bacterial isolates reported among patients with clinically absent infection. This paper reviews existing evidence on possible involvement of bacteria and microbial-associated molecular patterns in the pathology of so-called "aseptic loosening." © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:1497-1504, 2016.
['Wasko|Marcin K|MK|', 'Goodman|Stuart B|SB|']
D000900:Anti-Bacterial Agents D019644:Arthroplasty, Replacement, Hip D001424:Bacterial Infections D005188:False Negative Reactions D006801:Humans D011475:Prosthesis Failure
infection aseptic loosening total hip replacement microbial-associated molecular patterns osteolysis