Early Events in Coccidioidomycosis.
Since its description nearly 130 years ago, hundreds of studies have deepened our understanding of coccidioidomycosis, also known as valley fever (VF), and provided useful diagnostic tests and treatments for the disease caused by the dimorphic fungi Coccidioides spp. In general, most of the literature has addressed well-established infections and has described patients who have experienced major complications. In contrast, little attention has been given to the earliest consequences of the pathogen-host interaction and its implications for disease manifestation, progression, and resolution. The purpose of this review is to highlight published studies on early coccidioidomycosis, identify gaps in our knowledge, and suggest new or former research areas that might be or remain fertile ground for insight into the early stages of this invasive fungal disease.
['Donovan|Fariba M|FM|', 'Shubitz|Lisa|L|', 'Powell|Daniel|D|', 'Orbach|Marc|M|', 'Frelinger|Jeffrey|J|', 'Galgiani|John N|JN|']
D003045:Coccidioides D003047:Coccidioidomycosis D019468:Disease Management D004198:Disease Susceptibility D054884:Host-Pathogen Interactions D006801:Humans D007109:Immunity D008018:Life Cycle Stages
coccidioidomycosis early coccidioidomycosis Coccidioides research early events in valley fever