Risk factors for coronary artery lesions in children with Kawasaki disease.
Introduction
Kawasaki disease (KD) is a nonspecific systemic vasculitic disease that frequently occurs among children, and coronary artery lesion (CAL) is the most serious complication.


Objectives
We aimed to study the risk factors for CAL in children with KD.


Materials and methods
KD children in accordance with diagnostic criteria, who were hospitalized from January 2014 to December 2017, were selected as subjects. Univariate and multivariate logistic regression analyses were conducted to explore the relationships between CAL and gender, age, clinical diagnosis, erythrocyte sedimentation rate (ESR), platelet count, hemoglobin level, C reactive protein level, white blood cell count, initiation time of IVIG administration and duration of fever.


Results
The enrolled 982 KD children were divided into a CAL group (n = 104) and an NCAL group (n = 878) according to cardiac color Doppler ultrasonography. The incidence rate of CAL was 10.6 % (104/982). Univariate analysis showed that the two groups had significantly different gender, ESR, platelet count, initiation time of IVIG administration and duration of fever (P &#60; 0.05). Multivariate logistic regression analysis revealed that male gender, elevated ESR and delayed use of IVIG were independent risk factors for KD complicated with CAL.


Conclusions
Male gender, increased ESR and delayed use of IVIG were independent risk factors for KD complicated with CAL.
['Duan|Junyan|J|', 'Jiang|Huanhuan|H|', 'Lu|Ming|M|']
D001799:Blood Sedimentation D002648:Child D002675:Child, Preschool D003324:Coronary Artery Disease D003331:Coronary Vessels D005260:Female D005334:Fever D006760:Hospitalization D006801:Humans D016756:Immunoglobulins, Intravenous D007223:Infant D008297:Male D009080:Mucocutaneous Lymph Node Syndrome D010976:Platelet Count D012307:Risk Factors D012737:Sex Factors
risk factors coronary artery Kawasaki disease logistic regression