Risk of travel-related cases of Zika virus infection is predicted by transmission intensity in outbreak-affected countries.
BACKGROUND
Zika virus (ZIKV) infection is emerging globally, currently causing outbreaks in the Caribbean, and Central and South America, and putting travellers to affected countries at risk. Model-based estimates for the basic reproduction number (R 0 ) of ZIKV in affected Caribbean and Central and South American countries, obtained from 2015 to 2016 human case surveillance data, were compared by logistic regression and Receiver-Operating Characteristic (ROC), with the prevalence of ZIKV-positive test results in Canadians who travelled to them.


RESULTS
Estimates of R 0 for each country were a good predictor of the ZIKV test result (ROC area under the curve = 0.83) and the odds of testing positive was 11-fold greater for travellers visiting countries with estimated R 0  ≥ 2.76, compared to those visiting countries with R 0  < 2.76.


CONCLUSIONS
Risk to travellers varies widely amongst countries affected by ZIKV outbreaks. Estimates of R 0 from surveillance data can assist in assessing levels of risk for travellers and may help improve travel advice. They may also allow better prediction of spread of ZIKV from affected countries by travellers.
['Ogden|Nicholas H|NH|', 'Fazil|Aamir|A|', 'Safronetz|David|D|', 'Drebot|Michael A|MA|', 'Wallace|Justine|J|', 'Rees|Erin E|EE|', 'Decock|Kristina|K|', 'Ng|Victoria|V|']
D000569:Americas D050936:Basic Reproduction Number D004196:Disease Outbreaks D018562:Disease Transmission, Infectious D006801:Humans D018570:Risk Assessment D014195:Travel D000076082:Travel-Related Illness D000071243:Zika Virus Infection
Risk Zika virus Travellers Basic reproduction number