PDGF-C: a new performer in the neurovascular interplay.
The importance of neurovascular crosstalk in development, normal physiology, and pathologies is increasingly being recognized. Although vascular endothelial growth factor (VEGF), a prototypic regulator of neurovascular interaction, has been studied intensively, defining other important regulators in this process is warranted. Recent studies have shown that platelet-derived growth factor C (PDGF-C) is both angiogenic and a neuronal survival factor, and it appears to be an important component of neurovascular crosstalk. Importantly, the expression pattern and functional properties of PDGF-C and its receptors differ from those of VEGF, and thus the PDGF-C-mediated neurovascular interaction may represent a new paradigm of neurovascular crosstalk.
['Lee|Chunsik|C|', 'Zhang|Fan|F|', 'Tang|Zhongshu|Z|', 'Liu|Yizhi|Y|', 'Li|Xuri|X|']
D000818:Animals D001808:Blood Vessels D006801:Humans D008222:Lymphokines D009420:Nervous System D010982:Platelet-Derived Growth Factor D020239:Receptor Cross-Talk D017479:Receptors, Platelet-Derived Growth Factor D015398:Signal Transduction
PDGF-C neurovascular crosstalk survival angiogenesis neuroprotection