Triazole-based highly selective supramolecular sensor for the detection of diclofenac in real samples.
A triazole-based supramolecular chemosensor 6 for the selective spectrophotometric detection of diclofenac in human plasma and tap water was developed. The 6 was synthesized through click approach and characterized via UV-vis spectroscopy, FT-IR, Mass and NMR spectroscopy. The supramolecular interaction of compound 6 with commonly used drugs has been investigated with the help of UV-vis spectral titrations, FT-IR and (1)H, (13)C NMR spectroscopy. The UV-visible spectral changes upon addition of various commonly used drugs showed that compound 6 is highly selective for diclofenac over other drugs. The supramolecule 6 exhibited a selective enhancement in the absorbance intensity after mixing with diclofenac in human plasma and water samples in the presence of other drugs at pH 6-7, with a linear range of 0.938 (R(2)=0.938) and a limit of detection 10µM. The relative standard deviation (RSD) for 100µM diclofenac was found to be 0.462. The Job's plot analysis revealed that diclofenac bind to compound 6 in 1:1 stoichiometry.
['Ahmed|Farid|F|', 'Shah|Kiramat|K|', 'Awan|Iqra Zubair|IZ|', 'Shah|Muhammad Raza|MR|']
D000894:Anti-Inflammatory Agents, Non-Steroidal D004008:Diclofenac D057230:Limit of Detection D009682:Magnetic Resonance Spectroscopy D010949:Plasma D013056:Spectrophotometry, Ultraviolet D017550:Spectroscopy, Fourier Transform Infrared D014230:Triazoles D014867:Water
Diclofenac Chemosensors Tap water Human blood's plasma Supramolecular chemistry UV–visible spectrophotometery