Dietary supplementation with essence of chicken enhances daily oscillations in plasma glucocorticoid levels and behavioral adaptation to the phase-shifted environmental light-dark cycle in mice.
Maintenance of circadian rhythms is essential to many aspects of human health, including metabolism and neurological and psychiatric well-being. Chronic disruption of circadian clock function is implicated in increasing the risk of metabolic syndrome, cardiovascular events and development of cancers. However, there are little approaches to reinforce the function of circadian clock for prevention of these diseases. Essence of Chicken (EC) is a nutritional supplement that is traditionally made by extracting water soluble substances derived from cooking the whole chicken. In this study, we found that dietary supplementation with EC enhanced circadian oscillation of glucocorticoid secretion in mice, and this was accompanied by enhancement of circadian oscillation in the adrenal expression of steroidogenic acute regulatory (StAR) protein that mediates the rate-limiting step of glucocorticoid synthesis. Furthermore, EC facilitated re-entrainment of behavioral rhythm in mice when phase of the light-dark cycle was suddenly advanced. These results suggest that intake of EC has enhancement effect on circadian clock function in mice, which may contribute to sustain health and also offer new preventive strategies against circadian-related diseases.
['Dilixiati|Adila|A|', 'Koyanagi|Satoru|S|', 'Kusunose|Naoki|N|', 'Matsunaga|Naoya|N|', 'Ohdo|Shigehiro|S|']
D000311:Adrenal Glands D000818:Animals D001683:Biological Clocks D002645:Chickens D021081:Chronobiology Disorders D002940:Circadian Rhythm D019587:Dietary Supplements D004777:Environment D005938:Glucocorticoids D006801:Humans D008297:Male D008461:Meat Products D008810:Mice, Inbred C57BL D008813:Mice, Inbred ICR D010750:Phosphoproteins D017440:Photoperiod
Glucocorticoids Circadian rhythm EC StAR Aging Jet lag