Concise Review: Biomimetic Functionalization of Biomaterials to Stimulate the Endogenous Healing Process of Cartilage and Bone Tissue.
Musculoskeletal reconstruction is an ongoing challenge for surgeons as it is required for one out of five patients undergoing surgery. In the past three decades, through the close collaboration between clinicians and basic scientists, several regenerative strategies have been proposed. These have emerged from interdisciplinary approaches that bridge tissue engineering with material science, physiology, and cell biology. The paradigm behind tissue engineering is to achieve regeneration and functional recovery using stem cells, bioactive molecules, or supporting materials. Although plenty of preclinical solutions for bone and cartilage have been presented, only a few platforms have been able to move from the bench to the bedside. In this review, we highlight the limitations of musculoskeletal regeneration and summarize the most relevant acellular tissue engineering approaches. We focus on the strategies that could be most effectively translate in clinical practice and reflect on contemporary and cutting-edge regenerative strategies in surgery. Stem Cells Translational Medicine 2017;6:2186-2196.
['Taraballi|Francesca|F|0000-0002-4959-1169', 'Bauza|Guillermo|G|', 'McCulloch|Patrick|P|', 'Harris|Josh|J|', 'Tasciotti|Ennio|E|']
D000818:Animals D001861:Bone Regeneration D018786:Bone Substitutes D002356:Cartilage D006801:Humans D044968:Regenerative Medicine D055153:Stem Cell Niche D023822:Tissue Engineering
Tissue engineering Mesenchymal stem cells Stem cell-microenvironment interactions Tissue regeneration