Thiol/disulphide homeostasis as a novel indicator of oxidative stress in sudden sensorineural hearing loss.
OBJECTIVES
To investigate a novel oxidative stress marker, thiol/disulphide literature homeostasis, in patients with idiopathic sudden sensorineural hearing loss, and to compare the results with healthy controls for the first time.


METHODS
Thirty-two patients with idiopathic sudden sensorineural hearing loss and 30 healthy individuals were included in the study. Serum native thiol, total thiol and disulphide levels were measured, and disulphide/native thiol and disulphide/total thiol ratios were determined in all subjects.


RESULTS
Serum native thiol and total thiol levels were significantly lower in patients with sudden sensorineural hearing loss compared with controls (p < 0.05). Of the 32 patients, 25 had lower native thiol levels than controls (333.2 ± 73.9 vs 381.8 ± 35.6 μmol/l, p = 0.002) and 24 had lower total thiol levels (375.1 ± 74.3 vs 426.1 ± 39.3 μmol/l, p = 0.002).


CONCLUSION
The changes in oxidative markers evident in a significant number of patients may be associated with oxidative stress, which may, in turn, have caused sudden sensorineural hearing loss in those patients.
['Dinc|M E|ME|', 'Ulusoy|S|S|', 'Is|A|A|', 'Ayan|N N|NN|', 'Avincsal|M O|MO|', 'Bicer|C|C|', 'Erel|O|O|']
D000328:Adult D001301:Audiometry, Pure-Tone D016022:Case-Control Studies D004220:Disulfides D005260:Female D003639:Hearing Loss, Sudden D006706:Homeostasis D006801:Humans D008297:Male D008875:Middle Aged D018384:Oxidative Stress D011446:Prospective Studies D013438:Sulfhydryl Compounds
Thiols Oxidative Stress Sudden Hearing Loss Disulfides Reactive Oxygen Species