Seizure response to perampanel in drug-resistant epilepsy with gliomas: early observations.
Drug-resistant epilepsy (DRE) occurs commonly in gliomas, possibly due to a shared mechanism of AMPA-activation involving both seizure activity and tumor growth. We tested the AMPA-receptor blocker perampanel (PER) in patients with DRE in low- and high-grade gliomas. Seizure response was defined as 50% drop in seizure frequency or as seizure-freedom. Cognitive function was examined by computerized test on cognitive speed (CTCS), which is sensitive to the type of cognitive dysfunction associated with epilepsy and use of anticonvulsants. Treatment policy included reduction of dose or discontinuation of one or more concurrent AEDs, once a seizure-free response was observed. Twelve patients were included patients, median age 41 years, 9 men versus 3 women and 6 months median duration of follow-up. An objective seizure response (75%) was observed in 9 (75%) out of 12 patients: 50%-seizure response in 3, seizure-freedom in 6, which is plainly more than seen with other types of DRE. Side-effects occurred in six patients. Cognitive function as examined by CTCS improved in six out of eight associated withlowering of concurrent AEDs. The final median dose of PER was 8 mg (varying between 2 and 12 mg). These results of an objective seizure response in 9 (75%) out of 12 patients treated by PER in DRE may be interpreted as a surrogate-marker of tumor response secondary to AMPA blockade, advancing confirmation by MR imaging. These results warrant further study of PER on tumor activity in gliomas.
['Vecht|Charles|C|', 'Duran-Peña|Alberto|A|', 'Houillier|Caroline|C|', 'Durand|Thomas|T|', 'Capelle|Laurent|L|', 'Huberfeld|Gilles|G|']
D000328:Adult D000368:Aged D000927:Anticonvulsants D060825:Cognitive Dysfunction D004305:Dose-Response Relationship, Drug D000069279:Drug Resistant Epilepsy D005260:Female D005500:Follow-Up Studies D005910:Glioma D006801:Humans D008297:Male D008875:Middle Aged D009570:Nitriles D011728:Pyridones D012640:Seizures D016896:Treatment Outcome
Seizures Perampanel Drug-resistant epilepsy Glioma AMPA-receptor Glioblastoma Glutamate