Hyalinizing clear cell carcinoma of the parotid gland: report of a recurrent case with aggressive cytomorphology and behavior diagnosed on fine-needle cytology sample.
A case of recurrent hyalinizing clear cell carcinoma (HCCC) of the parotid gland in a 46-year-old female is here introduced. The patient had undergone a left superficial parotidectomy 6 months ago in another institution for an alleged benign, circumscribed mass 2.4 cm in diameter of the left parotid gland. Histopathological examination revealed a poorly differentiated HCCC bearing a EWSR-1 translocation on FISH examination. Fine Needle Cytology (FNC) was performed on three separate soft tissue masses in the pre-masseterine area and a cytological diagnosis of recurrent, poorly differentiated, possibly aggressive variant of HCCC, was rendered. FISH performed on a destained Diff Quik stained smear demonstrated an ESWR-1 translocation, which supported the cytopathological diagnosis. The cytomorphologic features and the differential diagnosis of this aggressive variant of HCCC are briefly discussed.
['Fulciniti|Franco|F|', 'Pia Curcio|Maria|M|', 'Liguori|Giuseppina|G|', 'Aquino|Gabriella|G|', 'Botti|Gerardo|G|', 'Campanile|Anna Cipolletta|AC|', 'De Cecio|Rossella|R|', 'Pavone|Ettore|E|', 'Aversa|Corrado|C|', 'Perri|Francesco|F|', 'Caponigro|Francesco|F|', 'Ionna|Franco|F|']
D018262:Adenocarcinoma, Clear Cell D014408:Biomarkers, Tumor D044963:Biopsy, Fine-Needle D005260:Female D006801:Humans D007633:Keratins D008875:Middle Aged D009364:Neoplasm Recurrence, Local D010307:Parotid Neoplasms D035583:Rare Diseases D014463:Ultrasonography
hyalinizing clear cell carcinoma of the parotid gland Fine needle cytology aggressive tumors of salivary glands rare salivary gland tumors salivary gland tumors