ARTIST: A fully automated artifact rejection algorithm for single-pulse TMS-EEG data.
Concurrent single-pulse TMS-EEG (spTMS-EEG) is an emerging noninvasive tool for probing causal brain dynamics in humans. However, in addition to the common artifacts in standard EEG data, spTMS-EEG data suffer from enormous stimulation-induced artifacts, posing significant challenges to the extraction of neural information. Typically, neural signals are analyzed after a manual time-intensive and often subjective process of artifact rejection. Here we describe a fully automated algorithm for spTMS-EEG artifact rejection. A key step of this algorithm is to decompose the spTMS-EEG data into statistically independent components (ICs), and then train a pattern classifier to automatically identify artifact components based on knowledge of the spatio-temporal profile of both neural and artefactual activities. The autocleaned and hand-cleaned data yield qualitatively similar group evoked potential waveforms. The algorithm achieves a 95% IC classification accuracy referenced to expert artifact rejection performance, and does so across a large number of spTMS-EEG data sets (n = 90 stimulation sites), retains high accuracy across stimulation sites/subjects/populations/montages, and outperforms current automated algorithms. Moreover, the algorithm was superior to the artifact rejection performance of relatively novice individuals, who would be the likely users of spTMS-EEG as the technique becomes more broadly disseminated. In summary, our algorithm provides an automated, fast, objective, and accurate method for cleaning spTMS-EEG data, which can increase the utility of TMS-EEG in both clinical and basic neuroscience settings.
['Wu|Wei|W|0000-0003-1901-9134', 'Keller|Corey J|CJ|0000-0003-0529-3490', 'Rogasch|Nigel C|NC|', 'Longwell|Parker|P|', 'Shpigel|Emmanuel|E|', 'Rolle|Camarin E|CE|', 'Etkin|Amit|A|']
D000328:Adult D000465:Algorithms D016477:Artifacts D004569:Electroencephalography D005260:Female D006801:Humans D008297:Male D010363:Pattern Recognition, Automated D012815:Signal Processing, Computer-Assisted D050781:Transcranial Magnetic Stimulation
artifact rejection electroencephalogram transcranial magnetic stimulation