Heterozygosity Ratio, a Robust Global Genomic Measure of Autozygosity and Its Association with Height and Disease Risk.
Greater genetic variability in an individual is protective against recessive disease. However, existing quantifications of autozygosity, such as runs of homozygosity (ROH), have proved highly sensitive to genotyping density and have yielded inconclusive results about the relationship of diversity and disease risk. Using genotyping data from three data sets with >43,000 subjects, we demonstrated that an alternative approach to quantifying genetic variability, the heterozygosity ratio, is a robust measure of diversity and is positively associated with the nondisease trait height and several disease phenotypes in subjects of European ancestry. The heterozygosity ratio is the number of heterozygous sites in an individual divided by the number of nonreference homozygous sites and is strongly affected by the degree of genetic admixture of the population and varies across human populations. Unlike quantifications of ROH, the heterozygosity ratio is not sensitive to the density of genotyping performed. Our results establish the heterozygosity ratio as a powerful new statistic for exploring the patterns and phenotypic effects of different levels of genetic variation in populations.
['Samuels|David C|DC|', 'Wang|Jing|J|', 'Ye|Fei|F|', 'He|Jing|J|', 'Levinson|Rebecca T|RT|', 'Sheng|Quanhu|Q|', 'Zhao|Shilin|S|', 'Capra|John A|JA|', 'Shyr|Yu|Y|', 'Zheng|Wei|W|', 'Guo|Yan|Y|']
D001827:Body Height D005787:Gene Frequency D020022:Genetic Predisposition to Disease D015894:Genome, Human D006579:Heterozygote D006801:Humans D011110:Polymorphism, Genetic
heterozygosity ratio height runs of homozygosity PheWAS