Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review.
BACKGROUND
There are accumulating studies reporting that vitamin E in general exhibits bone protective effects. This systematic review, however discusses the effects of a group of vitamin E isomers, tocotrienols in preventing bone loss through osteoclast differentiation and activity suppression.


OBJECTIVE
This review is aimed to discuss the literature reporting the effects of tocotrienols on osteoclasts, the cells specialized for resorbing bone.


RESULTS
Out of the total 22 studies from the literature search, only 11 of them were identified as relevant, which comprised of eight animal studies, two in vitro studies and only one combination of both. The in vivo studies indicated that tocotrienols improve the bone health and reduce bone loss via inhibition of osteoclast formation and resorption activity, which could be through regulation of RANKL and OPG expression as seen from their levels in the sera. This is well supported by data from the in vitro studies demonstrating the suppression of osteoclast formation and resorption activity following treatment with tocotrienol isomers.


CONCLUSION
Thus, tocotrienols are suggested to be potential antioxidants for prevention and treatment of bone-related diseases characterized by increased bone loss.
['Radzi|Nur Fathiah Mohd|NFM|', 'Ismail|Noor Akmal Shareela|NAS|', 'Alias|Ekram|E|']
D000818:Animals D000975:Antioxidants D001847:Bone Diseases D001862:Bone Resorption D001842:Bone and Bones D002454:Cell Differentiation D006801:Humans D010010:Osteoclasts D053245:RANK Ligand D024508:Tocotrienols
bone loss Osteoclast Osteoclast anti oxidants osteoblasts osteoclast tocotrienols.