CD30 expression in extranodal natural killer/T-cell lymphoma, nasal type among 622 cases of mature T-cell and natural killer-cell lymphoma at a single institution in South China.
BACKGROUND
Mature T-cell and natural killer (NK)-cell lymphomas compose a heterogeneous group of non-Hodgkin lymphomas, and extranodal NK/T-cell lymphoma, nasal type (ENKTL) is an aggressive subtype with sporadic CD30 expression. However, the significance of CD30 expression in ENKTL is controversial. We aimed to classify a large cohort of patients with mature T-cell and NK-cell lymphomas according to the 2016 World Health Organization (WHO) classification guidelines and to study the association between CD30 expression and prognosis of patients with ENKTL.


METHODS
We selected consecutive patients with mature T-cell and NK-cell lymphomas who attended our institution between September 1, 2009 and August 31, 2013. We classified the lymphomas according to the 2016 revision of the WHO classification of lymphoid neoplasms, analyzed the associations between CD30 expression and clinicopathologic features of ENKTL patients, and evaluated the prognostic implications of CD30 expression.


RESULTS
We identified 622 consecutive patients with mature T-cell and NK-cell lymphomas, including 317 (51.0%) patients with ENKTL. In addition, CD30 expression was detected in 43 (47.3%) of a subset of 91 patients with ENKTL. No clinicopathologic features were associated with CD30 expression, and CD30 positivity showed no prognostic significance in patients with ENKTL.


CONCLUSIONS
ENKTL is the most common type of mature T-cell and NK-cell lymphoma diagnosed at our institution. CD30 is frequently expressed in ENKTL and represents a therapeutic target; however, it may not be a prognostic marker.
['Feng|Yanfen|Y|', 'Rao|Huilan|H|', 'Lei|Yiyan|Y|', 'Huang|Yuhua|Y|', 'Wang|Fang|F|', 'Zhang|Yu|Y|', 'Xi|Shaoyan|S|', 'Wu|Qiuliang|Q|', 'Shao|Jianyong|J|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D014408:Biomarkers, Tumor D053285:CD30 Ligand D002648:Child D002675:Child, Preschool D002681:China D005260:Female D015972:Gene Expression Regulation, Neoplastic D004854:Herpesvirus 4, Human D006801:Humans D007694:Killer Cells, Natural D054391:Lymphoma, Extranodal NK-T-Cell D008297:Male D008875:Middle Aged D011379:Prognosis D013601:T-Lymphocytes
CD30 Lymphoma Epstein-Barr virus Natural killer cell T cell