Differential mechanisms of synaptic plasticity for susceptibility and resilience to chronic social defeat stress in male mice.
Mood dysregulation refers to the inability of a person to control their negative emotions, and it is linked to various stressful experiences. Dysregulated neural synaptic plasticity and actin-filament dynamics are important regulators of stress response in animal models. However, until now, there is no evidence to differential the mechanisms of synaptic plasticity and actin-filament dynamics in stress susceptibility and stress-resistant. Here we found that depression-like behaviour was observed in the susceptible group following chronic social defeat stress (CSDS) exposure, but not in stress-resistant mice. High-frequency stimulation-induced long-term potentiation (LTP) was impaired in the CSDS-induced depression-susceptible group. Further, the levels of pro-brain derived neurotrophic factor (BDNF), mature BDNF, PSD-95, phosphorylated CaMKII, and phosphorylated Cofilin, an actin-filament dynamics regulator, were reduced in CSDS-induced depression-susceptible mice unlike in stress-resistant mice. These results demonstrate that synaptic plasticity-related molecules, such as BDNF and phosphorylated Cofilin, are important for maintaining synaptic functions and structure in mice that experience more stress.
['Lee|Chi-Wei|CW|', 'Fang|Yen-Po|YP|', 'Chu|Ming-Chia|MC|', 'Chung|Yueh-Jung|YJ|', 'Chi|Hsiang|H|', 'Tang|Chih-Wei|CW|', 'So|Edmund Cheung|EC|', 'Lin|Hsin-Chuan|HC|', 'Lin|Hui-Ching|HC|']
D000818:Animals D001007:Anxiety D001522:Behavior, Animal D019208:Brain-Derived Neurotrophic Factor D002908:Chronic Disease D004198:Disease Susceptibility D017774:Long-Term Potentiation D008297:Male D008810:Mice, Inbred C57BL D009419:Nerve Tissue Proteins D009473:Neuronal Plasticity D010766:Phosphorylation D012919:Social Behavior D013315:Stress, Psychological D013569:Synapses
Chronic social defeat Stress Long-term potentiation Cofilin Brain derived neurotrophic factor