Alterations in the plasma metabolite profile associated with improved hepatic function and glycemia in mice fed lingonberry supplemented high-fat diets.
SCOPE
Lingonberries have been shown to reduce the detrimental effects of high-fat diet (HFD) on weight gain, plasma glucose, and inflammation. However, the extent of effects was recently shown to vary between different batches of berries. Here, we examine the metabolic response to two independent batches of lingonberries.


METHODS AND RESULTS
Alterations in the phenotype and circulating metabolome elicited by three matched HFDs, two of which containing lingonberries (L1D and L2D) from different sources, were investigated. Glycemia was improved only in mice fed L1D, whereas liver function was improved and inflammation reduced in mice fed both L1D and L2D, compared to mice fed HFD. The unique improvement in glycemia elicited by L1D was associated with a 21% increase in circulating levels of fatty acids. Increased levels of phosphatidylcholines (62%) and lysophosphatidylcholines (28%) and decreased levels of serine (-13%) and sphingomyelins (-26%) were observed in mice fed L1D and L2D, as compared to HFD.


CONCLUSION
The unique improvement in glycemia in mice fed L1D was associated with a normal metabolic control with an altered set point. Moreover, the batch-independent reduction in liver steatosis and inflammation, was associated with an altered sphingomyelin metabolism.
['Al Hamimi|Said|S|', 'Heyman-Lindén|Lovisa|L|', 'Plaza|Merichel|M|', 'Turner|Charlotta|C|', 'Berger|Karin|K|', 'Spégel|Peter|P|']
D000818:Animals D001786:Blood Glucose D059305:Diet, High-Fat D019587:Dietary Supplements D005227:Fatty Acids D008099:Liver D008297:Male D008810:Mice, Inbred C57BL D065626:Non-alcoholic Fatty Liver Disease D010636:Phenols D029801:Vaccinium vitis-idaea
Berries C57BL/6J Mass spectrometry Obesity Orthogonal projections to latent structures