Molecular, biophysical, and pharmacological properties of calcium-activated chloride channels.
Calcium-activated chloride channels (CaCCs) are a family of anionic transmembrane ion channels. They are mainly responsible for the movement of Cl- and other anions across the biological membranes, and they are widely expressed in different tissues. Since the Cl- flow into or out of the cell plays a crucial role in hyperpolarizing or depolarizing the cells, respectively, the impact of intracellular Ca2+ concentration on these channels is attracting a lot of attentions. After summarizing the molecular, biophysical, and pharmacological properties of CaCCs, the role of CaCCs in normal cellular functions will be discussed, and I will emphasize how dysregulation of CaCCs in pathological conditions can account for different diseases. A better understanding of CaCCs and a pivotal regulatory role of Ca2+ can shed more light on the therapeutic strategies for different neurological disorders that arise from chloride dysregulation, such as asthma, cystic fibrosis, and neuropathic pain.
['Kamaleddin|Mohammad Amin|MA|http://orcid.org/0000-0002-1856-503X']
D000818:Animals D001249:Asthma D002118:Calcium D018118:Chloride Channels D002712:Chlorides D003550:Cystic Fibrosis D006801:Humans D015640:Ion Channel Gating D008564:Membrane Potentials D049990:Membrane Transport Modulators D009437:Neuralgia D011487:Protein Conformation D015398:Signal Transduction D013329:Structure-Activity Relationship
calcium-activated chloride channel cystic fibrosis anoctamin chloride dynamic chloride regulation