Changes in secondary hyperparathyroidism-related biochemical parameters and medication use following parathyroidectomy.
BACKGROUND
Little is known about changes in parathyroid hormone (PTH), calcium and phosphorous levels after parathyroidectomy in hemodialysis patients. We studied the effects of parathyroidectomy on these biochemical values in a large cohort of patients receiving maintenance hemodialysis.


METHODS
This retrospective cohort study included patients identified in both the United States Renal Data System and the database of a large dialysis organization who underwent parathyroidectomy in 2007-09, were aged ≥ 18 years, had Medicare Parts A and B as primary payer and had received hemodialysis for ≥ 1 year pre-parathyroidectomy. Descriptive statistics were calculated for continuous variables; categorical variables were used to characterize the population and evaluate monthly laboratory and medication use; median values were calculated for laboratory measures.


RESULTS
Among 1402 parathyroidectomy patients, mean age was 48.9 years, 52.4% were males, 58.8% were African American and mean dialysis duration was 7.5 years. Median PTH levels increased over the year before parathyroidectomy from 1039 to 1661 pg/mL and decreased afterward to 98 pg/mL at 1 month; levels remained ≥ 897 pg/mL for 10% of patients. Median calcium levels fell from 9.6 mg/dL before to 7.9 mg/dL 1 month after parathyroidectomy; levels were ≤ 7.1 mg/dL for 25% and remained ≤ 7.2 mg/dL for the lowest 25% at 3 months. Median phosphorous level was 6.8 mg/dL immediately before parathyroidectomy, decreased to 3.8 mg/dL immediately after and reached 5.8 mg/dL at 1 year.


CONCLUSIONS
While PTH levels dropped after parathyroidectomy for most patients, surgery was sometimes ineffective in reducing levels and sometimes led to over-suppression. Hypocalcemia could be profound and long lasting, suggesting the need for prolonged vigilance.
['Wetmore|James B|JB|', 'Liu|Jiannong|J|', 'Do|Thy P|TP|', 'Lowe|Kimberly A|KA|', 'Ishani|Areef|A|', 'Bradbury|Brian D|BD|', 'Block|Geoffrey A|GA|', 'Collins|Allan J|AJ|']
D000328:Adult D000368:Aged D002118:Calcium D003131:Combined Modality Therapy D005260:Female D006801:Humans D006962:Hyperparathyroidism, Secondary D007676:Kidney Failure, Chronic D008297:Male D008875:Middle Aged D010281:Parathyroid Hormone D016105:Parathyroidectomy D010758:Phosphorus D006435:Renal Dialysis D012189:Retrospective Studies D055815:Young Adult
parathyroidectomy dialysis end-stage renal disease mineral metabolism secondary hyperparathyroidism