Down-regulated PLAC8 promotes hepatocellular carcinoma cell proliferation by enhancing PI3K/Akt/GSK3β/Wnt/β-catenin signaling.
Hepatocellular carcinoma (HCC) is a common, prevalent malignancy. Its poor prognosis is mainly related to high rate of diagnosis in non-curable stages, in which patients are suitable for palliative treatment. Placenta-specific 8 (PLAC8), also known as Onzin, is a small, highly conserved, cysteine-rich protein. In current study, we found that PLAC8 is prominently decreased in HCC tissues compared with adjacent tissues and patients with low level of PLAC8 suffered a poor prognosis. In addition, cellular function assays demonstrate that down-regulated PLAC8 promotes cell viability, proliferation and tumor formation both in vitro and in vivo. Furthermore, we validate that down-regulated PLAC8 enhances the activity of PI3K/Akt/GSK3β and Wnt/β-catenin signaling to promote cell proliferation. Moreover, we proved that highly expressed miR-185-5p targets PLAC8 in HCC tissues. In conclusion, our findings enlarged our knowledge about the roles of PLAC8 in HCC progression and miR-185-5p/PLAC8/β-catenin axis might be a novel pathway for HCC treatment.
['Zou|Lei|L|', 'Chai|Jie|J|', 'Gao|Yang|Y|', 'Guan|Jie|J|', 'Liu|Qi|Q|', 'Du|Jia-Jun|JJ|']
D000328:Adult D000368:Aged D006528:Carcinoma, Hepatocellular D049109:Cell Proliferation D015536:Down-Regulation D005260:Female D000071679:Glycogen Synthase Kinase 3 beta D056945:Hep G2 Cells D006801:Humans D008113:Liver Neoplasms D008297:Male D008875:Middle Aged D019869:Phosphatidylinositol 3-Kinases D011506:Proteins D051057:Proto-Oncogene Proteins c-akt D060449:Wnt Signaling Pathway D055815:Young Adult D051176:beta Catenin
PLAC8 Wnt/β-catenin signaling HCC miR-185-5p PI3K/Akt signaling