Development of forced normalisation psychosis with ethosuximide.
A 50-year-old man with known multidrug resistant coexistent focal and generalised epilepsy was commenced on ethosuximide, with normalisation of his electroencephalogram and cessation of absence seizures. Within 3 weeks, he developed a rapidly worsening paranoid psychosis with visual and olfactory hallucinations. A month after the cessation of ethosuximide and concurrent treatment with olanzapine, his psychosis resolved and permitted reinitiation of ethosuximide at a lower dose without recurrence of psychotic symptoms.
['Apap Mangion|Sean|S|', 'Rugg-Gunn|Fergus|F|']
D000927:Anticonvulsants D014150:Antipsychotic Agents D001569:Benzodiazepines D003937:Diagnosis, Differential D004569:Electroencephalography D004827:Epilepsy D005013:Ethosuximide D006212:Hallucinations D006801:Humans D008297:Male D008875:Middle Aged D000077152:Olanzapine D011618:Psychotic Disorders
clinical neurophysiology delusional disorder drugs: cns (not psychiatric) epilepsy and seizures