Sesquiterpene coumarins from Ferula samarkandica Korovin and their bioactivity.
Phytochemical study on the ethanolic extract of the dried roots of Ferula samarkandica Korovin led to the isolation of nine undiscribed sesquiterpene coumarins, samarcandicins A-I, along with thirteen known sesquiterpene coumarins. Their structures were characterized by detailed spectroscopic analysis including NMR and HR-ESI-MS. Mogoltacin and nevskin exhibited high inhibitory activity against MV-4-11 cell with IC50 values of 3.94 ± 0.06 μM and 3.87 ± 0.10 μM, respectively, and nevskin and feshurin showed high inhibitory activity against mino cell with IC50 values of 1.48 ± 0.06 μM and 7.88 ± 0.60 μM, respectively.
['Kamoldinov|Khamidulla|K|', 'Li|Jun|J|', 'Eshbakova|Komila|K|', 'Sagdullaev|Shamansur|S|', 'Xu|Gaoya|G|', 'Zhou|Yubo|Y|', 'Li|Jia|J|', 'Aisa|Haji Akber|HA|']
D003374:Coumarins D005309:Ferula D015394:Molecular Structure D018517:Plant Roots D012717:Sesquiterpenes
Sesquiterpene coumarin Ferula samarkandica Korovin MV-4-11 cell Mino cell Apiaceae Cytotoxity Samarcandicins A−I