Associations between persistent organic pollutants and risk of breast cancer metastasis.
BACKGROUND
Breast cancer (BC) is a major public health concern with over 2 million new cases diagnosed and over 600,000 deaths in 2018 in women worldwide. When distant metastases are present at diagnosis, the 5-year survival rate is only 26%. Recent studies have suggested that persistent organic pollutants (POPs) that accumulate in adipose tissue (AT) can influence tumor phenotype and stimulate cellular processes important for metastasis such as invasion. We, therefore, tested the hypothesis that POP exposure is associated with BC metastasis.


METHODS
We conducted an exploratory case-control study in which the concentrations of 49 POPs were measured in both AT and serum samples from BC patients, with or without lymph node metastasis, who underwent partial or total mastectomies, lymph node biopsies and sampling of the adipocytic tumor microenvironment. Adjusted, unconditional logistic models were used to study the associations between the POP concentrations and the risk of metastasis and other hallmarks of cancer aggressiveness.


RESULTS
2.3.7.8-TCDD concentrations in AT are positively associated with the risk of metastasis in 43 patients who have BMIs equal or higher than 25 kg/m2 (odds ratio: 4.48 (1.32-20.71)). Furthermore, the concentrations of 2.3.7.8-TCDD and two coplanar PCBs (77&169) in AT also were positively associated with the risk of lymph node metastasis and the tumor size.


CONCLUSION
Our study suggests that 2.3.7.8-TCDD and some PCBs contribute to the development of tumor metastasis and other hallmarks of cancer aggressiveness. While these results should be considered with caution, this is the first study to identify such potential risk factors. Larger longitudinal studies are necessary to confirm our results. Clinical Trial Protocol Record: 2013-A00663-42.
['Koual|Meriem|M|', 'Cano-Sancho|German|G|', 'Bats|Anne-Sophie|AS|', 'Tomkiewicz|Céline|C|', 'Kaddouch-Amar|Yael|Y|', 'Douay-Hauser|Nathalie|N|', 'Ngo|Charlotte|C|', 'Bonsang|Hélène|H|', 'Deloménie|Myriam|M|', 'Lecuru|Fabrice|F|', 'Le Bizec|Bruno|B|', 'Marchand|Philippe|P|', 'Botton|Jeremie|J|', 'Barouki|Robert|R|', 'Antignac|Jean-Philippe|JP|', 'Coumoul|Xavier|X|']
D000273:Adipose Tissue D000368:Aged D001943:Breast Neoplasms D016022:Case-Control Studies D015331:Cohort Studies D004785:Environmental Pollutants D005260:Female D006801:Humans D016015:Logistic Models D008875:Middle Aged D009362:Neoplasm Metastasis D016017:Odds Ratio D011078:Polychlorinated Biphenyls D012307:Risk Factors
Breast cancer Adipose tissue Serum Dioxins Endocrine disrupting chemicals Environmental exposure Organochlorine pesticides Perfluoroalkyl acid Polychlorinated biphenyls