Multiresponsive Nanogels for Targeted Anticancer Drug Delivery.
Nanogels with a biomolecular coating (biocoating) were shown to be capable of triggered delivery of anticancer drug Doxorubicin. The biocoating was formed utilizing binding between glycogen and the tetra-functional lectin Concanavalin A, which can be triggered to disassemble (and release) upon exposure to glucose and changes in solution pH. We also show the nanogel's thermoresponsivity can be used to accelerate Doxorubicin release. Moreover, we showed that transferrin immobilized on the nanogel surface could accelerate nanogel uptake by cancer cells. In these experiments, we showed that Doxorubicin was able to be released to the nucleus of human liver cancer cell line (HepG2) within 3 h. Doxorubicin-loaded nanogels exhibit a strong growth inhibition ability toward HepG2. This investigation showcases how nanogel design and chemistry can be tuned to achieve useful biomedical applications.
['Zhang|Qiang|Q|', 'Colazo|Juan|J|', 'Berg|Darren|D|', 'Mugo|Samuel M|SM|', 'Serpe|Michael J|MJ|0000-0002-0161-1087']
D000970:Antineoplastic Agents D002470:Cell Survival D003208:Concanavalin A D004317:Doxorubicin D004337:Drug Carriers D056945:Hep G2 Cells D006801:Humans D006863:Hydrogen-Ion Concentration D000080385:Nanogels D053758:Nanoparticles D011092:Polyethylene Glycols D011094:Polyethyleneimine D011108:Polymers
nanogels drug delivery biomolecular coatings stimuli-responsive polymers