Curcumin protects cortical neurons against oxygen and glucose deprivation/reoxygenation injury through flotillin-1 and extracellular signal-regulated kinase1/2 pathway.
In this study, we provided evidence that curcumin could be a promising therapeutic agent for ischemic stroke by activating neuroprotective signaling pathways. Post oxygen and glucose deprivation/reoxygenation (OGD/R), primary mouse cortical neurons treated with curcumin exhibited a significant decrease in cell death, LDH release and enzyme caspase-3 activity under OGD/R circumstances, which were abolished by flotillin-1 downregulation or extracellular signal-regulated kinase (ERK) inhibitor. Moreover, flotillin-1 knockdown led to suppression of curcumin-mediated ERK phosphorylation under OGD/R condition. Based on these findings, we concluded that curcumin could confer neuroprotection against OGD/R injury through a novel flotillin-1 and ERK1/2 pathway.
['Lu|Zhengyu|Z|', 'Liu|Yanping|Y|', 'Shi|Yang|Y|', 'Shi|Xinjie|X|', 'Wang|Xin|X|', 'Xu|Chuan|C|', 'Zhao|Hong|H|', 'Dong|Qiang|Q|']
D000818:Animals D002545:Brain Ischemia D002478:Cells, Cultured D002525:Cerebellar Cortex D003474:Curcumin D005260:Female D005947:Glucose D020935:MAP Kinase Signaling System D008297:Male D008565:Membrane Proteins D008807:Mice, Inbred BALB C D009474:Neurons D018696:Neuroprotective Agents D010100:Oxygen D015427:Reperfusion Injury
Curcumin Cortical neurons Oxygen and glucose deprivation/reoxygenation Flotillin-1 Mitogen-activated protein kinase