Efficacy and safety of fecal microbiota transplantation for the treatment of diseases other than Clostridium difficile infection: a systematic review and meta-analysis.
The intestinal microbiome has been identified as a key modifier for a variety of health conditions. Fecal Microbiota Transplantation (FMT) has emerged as a fast, safe, and effective means by which to modify the intestinal microbiome and potentially treat a variety of health conditions. Despite extensive research of FMT for CDI, there is a lack of clarity informed by systematic synthesis of data regarding the safety and efficacy of FMT for other health conditions. This systematic review used PRISMA guidelines and was prospectively registered with PROSPERO (CRD42018104243). In March 2020, a search of MEDLINE, EMBASE, and PsycINFO was conducted. We identified 26 eligible studies. A meta-analysis of FMT for active Ulcerative Colitis (UC) showed that FMT significantly improved rates of clinical remission (OR = 3.634, 95% CI = 1.940 to 6.808, I2 = 0%, p < .001), clinical response (OR = 2.634, 95% CI = 1.441 to 4.815, I2 = 33%, p = .002) and endoscopic remission (OR = 4.431, 95% CI = 1.901 to 10.324, I2 = 0%, p = .001). With respect to Irritable Bowel Syndrome, a meta-analysis showed no significant change in symptoms following FMT (p = .739). Hepatic disorders, metabolic syndrome, and antibiotic-resistant organisms were conditions with emerging data on FMT. Serious adverse events (AE) were more often reported in control group participants (n = 43) compared with FMT group participants (n = 26). There were similar rates of mild to moderate AE in both groups. Preliminary data suggest that FMT is a potentially safe, well-tolerated and efficacious treatment for certain conditions other than CDI, with evidence for active UC being the most compelling.
['Green|Jessica Emily|JE|', 'Davis|Jessica A|JA|', 'Berk|Michael|M|0000-0002-5554-6946', 'Hair|Christopher|C|', 'Loughman|Amy|A|0000-0002-0257-1443', 'Castle|David|D|0000-0002-3075-1580', 'Athan|Eugene|E|', 'Nierenberg|Andrew A|AA|', 'Cryan|John F|JF|0000-0001-5887-2723', 'Jacka|Felice|F|0000-0002-9825-0328', 'Marx|Wolfgang|W|']
D003093:Colitis, Ulcerative D024881:Drug Resistance, Bacterial D000069467:Fecal Microbiota Transplantation D000069196:Gastrointestinal Microbiome D006801:Humans D043183:Irritable Bowel Syndrome D008107:Liver Diseases D024821:Metabolic Syndrome D009765:Obesity D016896:Treatment Outcome
systematic review meta-analysis microbiome ulcerative colitis irritable bowel syndrome Fecal microbiota transplantation clostridium difficile RCT depression mental disorder neuroscience psychiatry