Polysomnographic abnormalities in patients with vascular cognitive impairment-no dementia.
OBJECTIVES
We aimed to investigate subjective sleep quality and polysomnographic sleep structure features in patients with vascular cognitive impairment-no dementia (VCIND).


METHODS
Fifty-six patients with VCIND, 48 patients with simple stroke (without cognitive impairment), and 48 control subjects were included. The Pittsburgh Sleep Quality Index (PSQI) and polysomnography (PSG) were used to analyze their sleep characteristics. The Montreal Cognitive Assessment (MoCA) was conducted to assess mental state.


RESULTS
Patients with VCIND had higher PSQI scores compared with control subjects and simple stroke patients (P<.01). PSG revealed that patients with VCIND or stroke were more likely to experience prolonged sleep latency (SL), decreased sleep efficiency (SE), increased arousal, and reduced deep sleep and rapid eye movement (REM) sleep than controls. Patients with VCIND had significantly longer SL, increased periodic leg movements in sleep (PLMS), decreased SE, and increased arousal and sleep fragmentation compared to patients with simple stroke (P<.05). In VCIND patients, a significant positive correlation was found between SE and MoCA scores (r=0.632; P<.001), though PSQI, SL, and arousal index were significantly negatively associated with MoCA scores (r=-0.787, -0.740, -0.772, respectively; P<.001 for all).


CONCLUSIONS
VCIND patients had different abnormal sleep features, including decreased SE, increased PLMS, and prolonged SL and sleep fragmentation. Abnormal sleep in VCIND may be associated with cognitive impairment.
['Jiang|Bo|B|', 'Ding|Chengyun|C|', 'Yao|Guoen|G|', 'Yao|Cunshan|C|', 'Zhang|Yunyan|Y|', 'Ge|Junling|J|', 'Qiu|Enchao|E|', 'Elia|Maurizio|M|', 'Ferri|Raffaele|R|']
D000328:Adult D002561:Cerebrovascular Disorders D003071:Cognition D003072:Cognition Disorders D003704:Dementia D056344:Executive Function D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D017286:Polysomnography D012894:Sleep Stages D012893:Sleep Wake Disorders D020521:Stroke
Vascular cognitive impairment-no dementia Dementia Sleep quality Sleep structure Polysomnography Sleep disorder