The Role of IL-9 Polymorphisms and Serum IL-9 Levels in Carcinogenesis and Survival Rate for Laryngeal Squamous Cell Carcinoma.
Recent studies have described the dichotomous function of IL-9 in various cancer diseases. However, its function has still not been analysed in laryngeal squamous cell carcinoma (LSCC). In the present study, we evaluated five single nucleotide polymorphisms (SNPs) of IL-9 (rs1859430, rs2069870, rs11741137, rs2069885, and rs2069884) and determined their associations with the patients' five-year survival rate. Additionally, we analysed serum IL-9 levels using an enzyme-linked immunosorbent assay. Three hundred LSCC patients and 533 control subjects were included in this study. A significant association between the patients' survival rate and distribution of IL-9 rs1859430 variants was revealed: patients carrying AA genotype had a higher risk of dying (p = 0.005). Haplotypes A-G-C-G-G of IL-9 (rs1859430, rs2069870, rs11741137, rs2069885, and rs2069884) were associated with 47% lower odds of LSCC occurrence (p = 0.035). Serum IL-9 levels were found detectable in three control group subjects (8.99 ± 12.03 pg/mL). In summary, these findings indicate that the genotypic distribution of IL-9 rs1859430 negatively influences the five-year survival rate of LSCC patients. The haplotypes A-G-C-G-G of IL-9 (rs1859430, rs2069870, rs11741137, rs2069885, and rs2069884) are associated with the lower odds of LSCC development.
['Pasvenskaite|Agne|A|', 'Liutkeviciene|Rasa|R|', 'Gedvilaite|Greta|G|', 'Vilkeviciute|Alvita|A|0000-0002-0427-5568', 'Liutkevicius|Vykintas|V|', 'Uloza|Virgilijus|V|']
D002294:Carcinoma, Squamous Cell D016022:Case-Control Studies D005260:Female D005787:Gene Frequency D020022:Genetic Predisposition to Disease D006239:Haplotypes D006801:Humans D016906:Interleukin-9 D007822:Laryngeal Neoplasms D015810:Linkage Disequilibrium D008297:Male D008875:Middle Aged D015999:Multivariate Analysis D020641:Polymorphism, Single Nucleotide D016016:Proportional Hazards Models D015996:Survival Rate
IL-9 survival rate laryngeal squamous cell carcinoma rs1859430 rs2069870 rs11741137 rs2069885 rs2069884 serum levels