Comparisons of predictive values of sarcopenia with different muscle mass indices in Korean rural older adults: a longitudinal analysis of the Aging Study of PyeongChang Rural Area.
Purpose
It is important to define lean muscle mass when diagnosing sarcopenia, but there is still controversy on the clinical implication of sarcopenia derived by height, weight, and body mass index (BMI) adjusted muscle mass indices. We aimed to evaluate the longitudinal clinical relevance of 3 sarcopenia definitions in the Korean population.


Patients and methods
We conducted comprehensive geriatric assessments for 1,379 community-dwelling older participants in the Aging Study of PyeongChang Rural Area (ASPRA) cohort and followed them up prospectively for death, institutionalization, and disability every 3 months. Sarcopenia was defined using the Asian Working Group consensus algorithm, combining grip strength, gait speed, and muscle mass.


Results
Among 1,343 participants (mean age: 76 years, 741 women) analyzed, there were 29 deaths and 89 institutionalizations during 22.0 ± 8.3 months follow-up (mean ± SD). All three muscle indices correlated to age and sex. All sarcopenia criteria with muscle mass indices of height, weight, and body mass index (BMI) adjustment significantly predicted death or institutionalization. However, when adjusted for age and sex, only the sarcopenia criteria with muscle mass index of height adjustment were significantly associated with major adverse health outcomes.


Conclusion
Adjusting age and gender, the sarcopenia definition from the quintile-based muscle index of height adjustment could predict death or institutionalization in Korean community-dwelling older adults.
['Jang|Il-Young|IY|', 'Jung|Hee-Won|HW|', 'Lee|Chang Ki|CK|', 'Yu|Sang Soo|SS|', 'Lee|Young Soo|YS|', 'Lee|Eunju|E|']
D000367:Age Factors D000368:Aged D000369:Aged, 80 and over D044466:Asians D015992:Body Mass Index D001837:Body Weights and Measures D005260:Female D015577:Geriatric Assessment D006801:Humans D057187:Independent Living D008297:Male D018482:Muscle, Skeletal D011446:Prospective Studies D056910:Republic of Korea D055948:Sarcopenia D012737:Sex Factors
sarcopenia muscle mass muscles geriatric assessment muscle index cohort studies frailty