Suppression of the Peripheral Immune System Limits the Central Immune Response Following Cuprizone-Feeding: Relevance to Modelling Multiple Sclerosis.
Cuprizone (CPZ) preferentially affects oligodendrocytes (OLG), resulting in demyelination. To investigate whether central oligodendrocytosis and gliosis triggered an adaptive immune response, the impact of combining a standard (0.2%) or low (0.1%) dose of ingested CPZ with disruption of the blood brain barrier (BBB), using pertussis toxin (PT), was assessed in mice. 0.2% CPZ(±PT) for 5 weeks produced oligodendrocytosis, demyelination and gliosis plus marked splenic atrophy (37%) and reduced levels of
['Sen|Monokesh K|MK|', 'Almuslehi|Mohammed S M|MSM|', 'Gyengesi|Erika|E|', 'Myers|Simon J|SJ|', 'Shortland|Peter J|PJ|', 'Mahns|David A|DA|', 'Coorssen|Jens R|JR|']
D056704:Adaptive Immunity D000818:Animals D001921:Brain D019295:Computational Biology D003471:Cuprizone D016207:Cytokines D003711:Demyelinating Diseases D004195:Disease Models, Animal D005911:Gliosis D007107:Immune System D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D017628:Microglia D008928:Mitochondria D009103:Multiple Sclerosis D009836:Oligodendroglia
demyelination oligodendrocytosis gliosis bioinformatics histology inside-out mitochondria outside-in top-down proteomics