'High vault-age': non-coding RNA control of autophagy.
RNA-binding proteins typically change the fate of RNA, such as stability, translation or processing. Conversely, we recently uncovered that the small non-coding vault RNA 1-1 (vtRNA1-1) directly binds to the autophagic receptor p62/SQSTM1 and changes the protein's function. We refer to this process as 'riboregulation'. Here, we discuss this newly uncovered vault RNA function against the background of three decades of vault RNA research. We highlight the vtRNA1-1-p62 interaction as an example of riboregulation of a key cellular process.
['Büscher|Magdalena|M|', 'Horos|Rastislav|R|', 'Hentze|Matthias W|MW|']
D000818:Animals D001343:Autophagy D005786:Gene Expression Regulation D006801:Humans D020871:RNA Stability D022661:RNA, Untranslated D000071456:Sequestosome-1 Protein
vault RNA 1-1 p62 riboregulation