Ni-Catalyzed Synthesis of Fluoroarenes via [2+2+2] Cycloaddition Involving α-Fluorine Elimination.
A method for direct synthesis of tetrasubstituted fluoroarenes via nickel-catalyzed [2+2+2] cycloaddition is presented. The reaction combines one molecule of 1,1-difluoroethylene with two molecules of alkynes and involves sequential cleavage of the C-F and C-H bonds in difluoroethylene. The catalytic cycle is established by reduction of the intermediary Ni(II) fluoride with a triethylborane-based borate.
['Fujita|Takeshi|T|', 'Watabe|Yota|Y|', 'Ichitsuka|Tomohiro|T|', 'Ichikawa|Junji|J|']
fluoroarenes alkynes CF bond activation fluoroalkenes nickel