Long-term use of ipragliflozin improved cardiac sympathetic nerve activity in a patient with heart failure: A case report.
Ipragliflozin is the first SGLT2 inhibitor approved in Japan. Reported here is a case where long-term administration of ipragliflozin decreased the rate of re-hospitalization due to heart failure (HF). An 83-year-old man with chronic HF and diabetes mellitus (DM) was hospitalized four times in the last five years. He was discharged six months after his last hospitalization, but he continued to have class III HF according to the New York Heart Association classification (NYHA), and his DM was also not properly managed. Therefore, he received ipragliflozin. One year after initiation of ipragliflozin, he lost weight (body weight (BW): 79.0 to 76.2 kg), his levels of brain natriuretic peptide (BNP) decreased (191.4 to 122.5 mg/dL), and the class of his HF improved (class III to class II). The management of DM also improved (fasting blood glucose: 100 to 110 mg/dL; hemoglobin A1C: 6.8 to 6.6%). In addition, cardiac sympathetic nerve function evaluated with 123I-metaiodobenzylguanidine cardiac-scintigraphy (123I-MIBG) also improved (the average of the heart-to-mediastinum ratio in early and delayed phases; 1.44 to 2.17 in the early phase, 1.41 to 1.92 in the delayed phase, washout rate; 43.3 to 35.6). The patient was not re-hospitalized due to HF two years after administration of ipragliflozin started. A reduction in cardiac sympathetic nerve hyperactivity by an SGLT2 inhibitor might be one of the mechanisms of its cardio-protective effect, but clinical studies need to be conducted to verify this finding.
['Kiuchi|Shunsuke|S|', 'Hisatake|Shinji|S|', 'Kabuki|Takayuki|T|', 'Fujii|Takahiro|T|', 'Oka|Takashi|T|', 'Dobashi|Shintaro|S|', 'Hashimoto|Hidenobu|H|', 'Ikeda|Takanori|T|']
D000369:Aged, 80 and over D001835:Body Weight D005960:Glucosides D006333:Heart Failure D006760:Hospitalization D006801:Humans D008297:Male D055414:Myocardial Perfusion Imaging D013564:Sympathetic Nervous System D013876:Thiophenes D016896:Treatment Outcome
Ipragliflozin cardiac sympathetic nerve activity heart failure diabetes mellitus