Comparative clinical study on microwave ablation combined with gemcitabine and cisplatin or combined with pemetrexed and cisplatin in treatment of advanced NSCLC.
OBJECTIVE
Solving the limitations of single chemotherapy in the treatment of non-small cell lung cancer (NSCLC).


METHODS
About 100 patients with NSCLC treated in First Hospital of Jiaxing, Zhejiang from June 2016 to June 2018 were selected and randomly divided into MPC group and MGC group, with 50 cases in each group. The patients in MPC group were treated with microwave ablation (MWA) combined with PC while patients in MGC group were given MWA combined with gemcitabine plus cisplatin (GC). The therapeutic effects of the two groups as well as the complications and adverse reactions (ADRs) were observed and recorded.


RESULTS
There was no significant difference in disease response rate (MPC group 33.3% vs MGC group 32.0%), disease control rate (MPC group 86.4% vs MGC group 78.0%) and overall survival (1-, 2- and 3-year survival, MPC group 65%, 59%, 32.7% vs MGC group 58%, 46%, 30%) between the two groups. In addition, the ADR myelosuppression was slighter in MPC group. There were 12 cases (23%) developed myelosuppression in the MPC group and 20 cases (42%) in MGC group, with a significant difference between the two groups (P < 0.05). The treatment was interrupted for 0 case (0%) in MPC group because of myelosuppression while 4 cases (8.3%) in MGC group.


CONCLUSION
The two therapeutic regimens have similar efficacy in treatment of advanced NSCLC, but MPC causes slighter myelosuppression and can be the first-line therapy for advanced NSCLC.
['Zhang|YingQing|Y|', 'Feng|Yan|Y|', 'Wu|YongLei|Y|', 'Zhou|YingXin|Y|', 'Wang|LinLan|L|']
D000971:Antineoplastic Combined Chemotherapy Protocols D002289:Carcinoma, Non-Small-Cell Lung D002945:Cisplatin D003841:Deoxycytidine D005971:Glutamates D006147:Guanine D006801:Humans D008175:Lung Neoplasms D008872:Microwaves D009367:Neoplasm Staging D000068437:Pemetrexed D016896:Treatment Outcome
microwave ablation gemcitabine cisplatin pemetrexed non-small cell cancer