Influence of 4 weeks of bovine colostrum supplementation on neutrophil and mucosal immune responses to prolonged cycling.
Bovine colostrum (COL) has been advocated as a nutritional countermeasure to exercise-induced immune dysfunction. The aims of this study were to identify the effects of 4 weeks of COL supplementation on neutrophil responses and mucosal immunity following prolonged exercise. In a randomized double-blind, parallel group design, participants [age 28 ± 8 years; body mass 79 ± 7 kg; height 182 ± 6 cm; maximal oxygen uptake (V̇O2max) 55 ± 9 mL/kg/min] were assigned to 20 g per day of COL (n = 10) or an isoenergetic/isomacronutrient placebo (PLA; n = 10) for 4 weeks. Venous blood and unstimulated saliva samples were obtained before and after 2.5 h of cycling at 15% Δ (∼55-60% V̇O2max). A significantly greater formyl-methionyl-leucyl phenylalanine-stimulated oxidative burst was observed in the COL group compared with PLA group (P < 0.05) and a trend toward a time × group interaction (P = 0.06). However, there was no effect of COL on leukocyte trafficking, phorbol-12-myristate-13-acetate-stimulated oxidative burst, bacterial-stimulated neutrophil degranulation, salivary secretory IgA, lactoferrin or lysozyme (P > 0.05). These findings provide further evidence of the beneficial effects of COL on receptor-mediated stimulation of neutrophil oxidative burst in a model of exercise-induced immune dysfunction.
['Jones|A W|AW|', 'Thatcher|R|R|', 'March|D S|DS|', 'Davison|G|G|']
D000328:Adult D000818:Animals D002417:Cattle D015550:Cell Degranulation D003126:Colostrum D019587:Dietary Supplements D004311:Double-Blind Method D015444:Exercise D006801:Humans D007070:Immunoglobulin A D007958:Leukocyte Count D009061:Mouth Mucosa D009240:N-Formylmethionine Leucyl-Phenylalanine D009504:Neutrophils D061251:Primary Cell Culture D016897:Respiratory Burst D012463:Saliva D013755:Tetradecanoylphorbol Acetate D055815:Young Adult
exercise leukocyte Immune function antimicrobial peptides innate immune system