Assessing the role of IL-35 in colorectal cancer progression and prognosis.
Despite the recent realization of Interleukin (IL)-35 in tumorigenesis, its exact impact on colorectal cancer (CRC) progression and prognosis, however, is yet to be elucidated clearly. We thus in the present report conducted comparative analysis of IL-35 levels between CRC patients and matched control subjects. IL-35 is highly expressed in all CRC tissues, which can be detected in vast majority of colorectal cancer cells. IL-35 levels in CRC lysates and serum samples are highly correlated to the severity of malignancy and the clinical stage of tumor. Particularly, a significant reduction for serum IL-35 was noted in patients after surgical resection, indicating that IL-35 promotes CRC progression associated with poor prognosis. Mechanistic study demonstrated a significant correlation between serum IL-35 levels and the number of peripheral regulatory T (Treg) cells in CRC patients, suggesting that IL-35 implicates in CRC pathogenesis probably by inducing Treg cells, while cancer cell-derived IL-35 may also recruit Treg cells into the tumor microenvironment in favor of tumor growth. Together, our data support that IL-35 could be a valuable biomarker for assessing CRC progression and prognosis in clinical settings.
['Zeng|Jin-Cheng|JC|', 'Zhang|Zhi|Z|', 'Li|Tian-Yu|TY|', 'Liang|Yan-Fang|YF|', 'Wang|Hong-Mei|HM|', 'Bao|Jing-Jing|JJ|', 'Zhang|Jun-Ai|JA|', 'Wang|Wan-Dang|WD|', 'Xiang|Wen-Yu|WY|', 'Kong|Bin|B|', 'Wang|Zhi-Yong|ZY|', 'Wu|Bin-Hua|BH|', 'Chen|Xiao-Dong|XD|', 'He|Long|L|', 'Zhang|Shu|S|', 'Wang|Cong-Yi|CY|', 'Xu|Jun-Fa|JF|']
D048868:Adaptor Proteins, Signal Transducing D000328:Adult D000368:Aged D014408:Biomarkers, Tumor D016022:Case-Control Studies D018797:Cell Cycle Proteins D002634:Chemotaxis, Leukocyte D003082:Colectomy D015179:Colorectal Neoplasms D018450:Disease Progression D005260:Female D006801:Humans D007378:Interleukins D016246:Lymphocytes, Tumor-Infiltrating D008297:Male D008875:Middle Aged D015778:Minor Histocompatibility Antigens D060787:Neoplasm Grading D009367:Neoplasm Staging D050378:T-Lymphocytes, Regulatory D016896:Treatment Outcome D059016:Tumor Microenvironment D055815:Young Adult
colorectal cancer EBI3 IL-12p35 Interleukin-35 regulatory T cell