Role of soluble adenylyl cyclase in mitochondria.
The soluble adenylyl cyclase (sAC) catalyzes the conversion of ATP into cyclic AMP (cAMP). Recent studies have shed new light on the role of sAC localized in mitochondria and its product cAMP, which drives mitochondrial protein phosphorylation and regulation of the oxidative phosphorylation system and other metabolic enzymes, presumably through the activation of intra-mitochondrial PKA. In this review article, we summarize recent findings on mitochondrial sAC activation by bicarbonate (HCO(3)(-)) and calcium (Ca²⁺) and the effects on mitochondrial metabolism. We also discuss putative mechanisms whereby sAC-mediated mitochondrial protein phosphorylation regulates mitochondrial metabolism. This article is part of a Special Issue entitled: The role of soluble adenylyl cyclase in health and disease.
['Valsecchi|Federica|F|', 'Konrad|Csaba|C|', 'Manfredi|Giovanni|G|']
D000262:Adenylyl Cyclases D017868:Cyclic AMP-Dependent Protein Kinases D004789:Enzyme Activation D006801:Humans D008928:Mitochondria D010085:Oxidative Phosphorylation
Mitochondria sAC cAMP Protein phosphorylation PKA