Interactions Between the Aging Gut Microbiome and Common Geriatric Giants: Polypharmacy, Frailty, and Dementia.
The gut microbiome has pervasive bidirectional relationships with pharmacotherapy, chronic disease, and physical and cognitive function. We conducted a narrative review of the current literature to examine the relationships between the gut microbiome, medication use, sarcopenia and frailty, and cognitive impairment. Data from in vitro experiments, in vivo experiments in invertebrates and complex organisms, and humans indicate associations between the gut microbiome and geriatric syndromes. Better understanding of the direct and indirect roles of the microbiome may inform future prevention and management of geriatric syndromes.
['Gemikonakli|Gizem|G|', 'Mach|John|J|', 'Hilmer|Sarah Nicole|SN|0000-0002-5970-1501']
D000375:Aging D000818:Animals D003704:Dementia D000073496:Frailty D000069196:Gastrointestinal Microbiome D006801:Humans D008954:Models, Biological D019338:Polypharmacy
Polypharmacy Sarcopenia Cognitive decline Microbiota Pharmacology