Modelling the early evolution of extracellular matrix from modern Ctenophores and Sponges.
Animals (metazoans) include some of the most complex living organisms on Earth, with regard to their multicellularity, numbers of differentiated cell types, and lifecycles. The metazoan extracellular matrix (ECM) is well-known to have major roles in the development of tissues during embryogenesis and in maintaining homoeostasis throughout life, yet insight into the ECM proteins which may have contributed to the transition from unicellular eukaryotes to multicellular animals remains sparse. Recent phylogenetic studies place either ctenophores or poriferans as the closest modern relatives of the earliest emerging metazoans. Here, we review the literature and representative genomic and transcriptomic databases for evidence of ECM and ECM-affiliated components known to be conserved in bilaterians, that are also present in ctenophores and/or poriferans. Whereas an extensive set of related proteins are identifiable in poriferans, there is a strikingly lack of conservation in ctenophores. From this perspective, much remains to be learnt about the composition of ctenophore mesoglea. The principal ECM-related proteins conserved between ctenophores, poriferans, and bilaterians include collagen IV, laminin-like proteins, thrombospondin superfamily members, integrins, membrane-associated proteoglycans, and tissue transglutaminase. These are candidates for a putative ancestral ECM that may have contributed to the emergence of the metazoans.
['Draper|Graham W|GW|', 'Shoemark|Deborah K|DK|', 'Adams|Josephine C|JC|0000-0002-2225-4947']
D000595:Amino Acid Sequence D000818:Animals D005075:Biological Evolution D037302:Ctenophora D005109:Extracellular Matrix D016326:Extracellular Matrix Proteins D023281:Genomics D011161:Porifera D000072417:Protein Domains D020543:Proteome D059467:Transcriptome
Multicellularity Integrins Ctenophora Metazoa Porifera Protein Domains