Mini review-vanadium-induced neurotoxicity and possible targets.
Vanadium, a transition metal, ubiquitous in nature is known to have therapeutic effect as well as toxic effect. It is known to possess antidiabetic, antitumor and antiparasitic activity. However, on long term exposure, it produces neurotoxicity which may result in memory impairment. The possible mechanism known to cause neurotoxicity suggested is oxidative stress and inflammation of neuronal cells. The present review has focused on discussing the role of protein P38 mitogen-activated protein kinase and oxidative stress as possible targets to treat vanadium-induced neurotoxicity.
['Jaiswal|Madhuri Ramji|MR|', 'Kale|Pravin Popatrao|PP|http://orcid.org/0000-0003-2957-1037']
D000818:Animals D006801:Humans D007249:Inflammation D020928:Mitogen-Activated Protein Kinases D020258:Neurotoxicity Syndromes D018384:Oxidative Stress D047428:Protein Kinase Inhibitors D014131:Trace Elements D014639:Vanadium
Neurotoxicity Vanadium Oxidative stress COX 2 Neuroinflammation p38MAPK