Quality Control of Compounded Crystalloid Fluids for Intravenous Delivery to Horses.
BACKGROUND
Periodic lack of availability and high cost of commercially produced isotonic fluids for intravenous (IV) use in horses have increasingly led to use of home-made or commercially compound fluids by veterinarians. Data regarding the quality control and safety of compounded fluids would be of benefit to equine veterinarians.


OBJECTIVES
To compare electrolyte concentrations, sterility, and endotoxin contamination of commercially available fluids to 2 forms of compounded isotonic crystalloid fluids intended for IV use in horses.


METHODS
Prospective study. Two methods of preparing compounded crystalloids formulated to replicate commercial Plasma-Lyte A (Abbott, Chicago, IL) were compared. One formulation was prepared by a hand-mixed method involving chlorinated drinking water commonly employed by equine practitioners, and the other was prepared by means of ingredients obtained from a commercial compounding pharmacy. The variables for comparison were electrolyte concentrations, sterility, and presence of endotoxin contamination.


RESULTS
Electrolyte concentrations were consistent within each product but different between types of fluids (P < 0.0001). Hand-mixed fluids had significantly more bacterial contamination compared to commercial Plasma-Lyte A (P = 0.0014). One of the hand-mixed fluid samples had detectable endotoxin contamination.


CONCLUSIONS AND CLINICAL IMPORTANCE
Chlorinated drinking water is not an acceptable source of water to compound isotonic fluids for IV administration. Equine practitioners should be aware of this risk and obtain the informed consent of their clients.
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D000818:Animals D000077324:Crystalloid Solutions D004339:Drug Compounding D004340:Drug Contamination D004573:Electrolytes D004731:Endotoxins D006736:Horses D007262:Infusions, Intravenous D007552:Isotonic Solutions D011786:Quality Control D014867:Water
Equine Electrolytes Sterility Endotoxin