Establishment of a Disease-Specific Graded Prognostic Assessment for Hepatocellular Carcinoma Patients with Spinal Metastasis.
Background/Aims
Hepatocellular carcinoma (HCC) patients with spinal metastasis (SM) show heterogeneous lengths of survival. In this study, we develop and propose a graded prognostic assessment for HCC patients with SM (HCC-SM GPA).


Methods
We previously reported the outcomes of 192 HCC patients with SM who received radiotherapy from April 1992 to February 2012. Prognostic factors that significantly affected survival in that study were used to establish the HCC-SM GPA. Validation was performed using an independent cohort of 63 patients recruited from September 2011 to March 2016.


Results
We developed the HCC-SM GPA using the following factors: Eastern Cooperative Oncology Group performance status (0-2, 0 point; 3-4, 1 point), controlled primary HCC (yes, 0 point; no, 2 points), and extrahepatic metastases other than bone (no, 0 point; yes, 1 point). Patients were stratified into low (GPA=0), intermediate (GPA=1 to 2), and high risk (GPA=3 to 4). When applied to the validation cohort, the HCC-SM GPA determined median survival durations of 13.6, 4.8, and 2.6 months and 1-year overall survival rates of 58.3%, 17.8%, and 7.3% for the low-, intermediate-, and high-risk patient groups, respectively (p<0.001).


Conclusions
Our newly proposed HCC-SM GPA successfully predicted survival outcomes.
['Rim|Chai Hong|CH|', 'Choi|Chiwhan|C|', 'Choi|Jinhyun|J|', 'Seong|Jinsil|J|']
D006528:Carcinoma, Hepatocellular D015331:Cohort Studies D005260:Female D006801:Humans D008113:Liver Neoplasms D008297:Male D008875:Middle Aged D011379:Prognosis D018570:Risk Assessment D013125:Spinal Neoplasms D016019:Survival Analysis D015996:Survival Rate
Graded prognostic assessment Spinal metastasis Survival Carcinoma, hepatocellular