Yersinia Outer Membrane Vesicles as Potential Vaccine Candidates in Protecting against Plague.
Despite the relatively low incidence of plague, its etiological agent, Yersinia pestis, is an exceptional epidemic danger due to the high infectivity and mortality of this infectious disease. Reports on the isolation of drug-resistant Y. pestis strains indicate the advisability of using asymmetric responses, such as phage therapy and vaccine prophylaxis in the fight against this problem. The current relatively effective live plague vaccine is not approved for use in most countries because of its ability to cause heavy local and system reactions and even a generalized infectious process in people with a repressed immune status or metabolic disorders, as well as lethal infection in some species of nonhuman primates. Therefore, developing alternative vaccines is of high priority and importance. However, until now, work on the development of plague vaccines has mainly focused on screening for the potential immunogens. Several investigators have identified the protective potency of bacterial outer membrane vesicles (OMVs) as a promising basis for bacterial vaccine candidates. This review is aimed at presenting these candidates of plague vaccine and the results of their analysis in animal models.
['Byvalov|Andrey A|AA|', 'Konyshev|Ilya V|IV|', 'Uversky|Vladimir N|VN|0000-0002-4037-5857', 'Dentovskaya|Svetlana V|SV|0000-0002-1996-8949', 'Anisimov|Andrey P|AP|0000-0002-5499-7999']
D000818:Animals D000942:Antigens, Bacterial D001425:Bacterial Outer Membrane Proteins D001426:Bacterial Proteins D006801:Humans D007107:Immune System D007074:Immunoglobulin G D051379:Mice D010930:Plague D010931:Plague Vaccine D014612:Vaccines D015010:Yersinia pestis
outer membrane vesicles Yersinia pestis plague vaccine protective antigen