Risk factors analysis for hyperuricemic nephropathy among CKD stages 3-4 patients: an epidemiological study of hyperuricemia in CKD stages 3-4 patients in Ningbo, China.
OBJECTIVE
Uric acid (UA) is a risk marker of CKD and SUA level in CKD 3-4 patients closely correlates with hyperuricemic nephropathy (HN) morbidity. This study was designed to evaluate the risk factors for HN in CKD 3-4 patients.


METHODS
The 461 CKD 3-4 patients were recruited and all patients were divided into three groups (24 h UUA normal, underexeret, and overproduct type groups) according to the 24 h UUA level after receiving low purine food for five days. Clinical and biochemical characteristics of CKD patients were collected for the logistic regression analysis. Correlation analysis of the mRNA relative expression level of hUAT and hURAT1 with serum UA (SUA) level also was evaluated.


RESULTS
There were significant increases in characteristics including average age, waist-to-height ratio (WHR), SUA levels, HN ratio, TG/HDL ratio, body mass index (BMI), blood pressure (BP), uNgal/Cr. ratio, and uKim-1/Cr. ratio in overproduct type group in comparison with the other two groups. Logistic regression analysis showed SUA, CHO, uKim-1/Cr. ratio and uNgal/Cr. ratio were independent and multiple risk factors for HN. Moreover, hUAT and hURAT1 mRNA relative expression levels were significantly correlated with SUA level in the underexeret type CKD 3-4 patients.


CONCLUSIONS
These results showed SUA and other characteristics contributed to HN morbidity in CKD 3-4 patients.
['Wu|Yong-Yao|YY|', 'Qiu|Xiao-Hui|XH|', 'Ye|Yun|Y|', 'Gao|Chao|C|', 'Wu|Fuquan|F|', 'Xia|Guihua|G|']
D000328:Adult D000368:Aged D001794:Blood Pressure D015992:Body Mass Index D002681:China D016021:Epidemiologic Studies D005260:Female D006801:Humans D033461:Hyperuricemia D008297:Male D008875:Middle Aged D027361:Organic Anion Transporters D027701:Organic Cation Transport Proteins D012333:RNA, Messenger D012044:Regression Analysis D051436:Renal Insufficiency, Chronic D012307:Risk Factors D012737:Sex Factors D014527:Uric Acid
hyperuricemic nephropathy hyperuricemia hUAT CKD 3–4 serum uric acid