Copper-catalyzed cascade reactions of α,β-unsaturated esters with keto esters.
A copper-catalyzed cascade reaction of α,β-unsaturated esters with keto esters is reported. It features a copper-catalyzed reductive aldolization followed by a lactonization. This method provides a facile approach to prepare γ-carboxymethyl-γ-lactones and δ-carboxymethyl-δ-lactones under mild reaction conditions.
['Li|Zhengning|Z|', 'Wang|Chongnian|C|', 'Li|Zengchang|Z|']
cascade reaction lactonization aldol addition catalysis conjugate reduction copper