Influence of curcumin-loaded cationic liposome on anticancer activity for cervical cancer therapy.
The delivery of curcumin has been explored in the form of liposomal nanoparticles to treat various cancer cells. Since curcumin is water insoluble and an effective delivery route is through encapsulation in liposomes, which were modified with three components of DDAB, cholesterol and non-ionic surfactant. The purpose of this study was to establish a critical role of DDAB in liposomes containing curcumin at cellular response against two types of cell lines (HeLa and SiHa). Here, we demonstrate that DDAB is a potent inducer of cell uptake and cell death in both cell lines. The enhanced cell uptake was found on DDAB-containing liposome, but not on DDAB-free liposome. However, the cytotoxicity of DDAB-containing liposomes was high and needs to be optimized. The cytotoxicity of liposomal curcumin was more pronounced than free curcumin in both cells, suggesting the benefits of using nanocarrier. In addition, the anticancer efficiency and apoptosis effect of the liposomal curcumin formulations with DDAB was higher than those of DDAB-free liposomes. Therefore curcumin loaded liposomes indicate significant potential as delivery vehicles for the treatment of cervical cancers.
['Saengkrit|Nattika|N|', 'Saesoo|Somsak|S|', 'Srinuanchai|Wanwisa|W|', 'Phunpee|Sarunya|S|', 'Ruktanonchai|Uracha Rungsardthong|UR|']
D000970:Antineoplastic Agents D002412:Cations D016923:Cell Death D045744:Cell Line, Tumor D048430:Cell Shape D002470:Cell Survival D003474:Curcumin D004705:Endocytosis D005260:Female D006801:Humans D008081:Liposomes D018625:Microscopy, Atomic Force D010316:Particle Size D055672:Static Electricity D002583:Uterine Cervical Neoplasms
Liposomes Cervical cancer Curcumin Cholesterol Surfactant