CT assessment of tumor heterogeneity and the potential for the prediction of human papillomavirus status in oropharyngeal squamous cell carcinoma.
The aim of this study is to find a correlation between tumoral heterogeneity of squamous cell carcinoma of the oropharynx and human papillomavirus (HPV) status and to determine whether analysis of texture features of primary lesion on contrast-enhanced CT (CECT) images can be useful in predicting the HPV positivity. Fifty patients with diagnosis of oropharyngeal carcinoma and pre-treatment CECT were included; tumoral heterogeneity of each lesion was evaluated by extracting quantitative texture parameters of first and higher orders. T test and logistic regression were conducted to evaluate the effects of different textural characteristics. There were 35 HPV+ and 15 HPV- lesions. Statistically significant (p < 0.05) differences were seen in multiple higher-order extracted parameters. The logistic regression model correctly classified lesions with an accuracy of 95.2%. CT texture analysis of primary oropharyngeal cancer may be used as a tool for predicting the HPV status.
['Mungai|Francesco|F|', 'Verrone|Giovanni Battista|GB|', 'Pietragalla|Michele|M|', 'Berti|Valentina|V|', 'Addeo|Gloria|G|', 'Desideri|Isacco|I|', 'Bonasera|Luigi|L|', 'Miele|Vittorio|V|']
D000368:Aged D000078331:Correlation of Data D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D009367:Neoplasm Staging D009959:Oropharyngeal Neoplasms D030361:Papillomavirus Infections D011237:Predictive Value of Tests D012189:Retrospective Studies D000077195:Squamous Cell Carcinoma of Head and Neck D014057:Tomography, X-Ray Computed
Human papillomavirus Texture analysis Oropharyngeal cancer Computed tomography Head and neck imaging