Benefits of Fish Oil Consumption over Other Sources of Lipids on Metabolic Parameters in Obese Rats.
This study evaluated the effect of the consumption of different levels and sources of lipids on metabolic parameters of Wistar rats. Animals were fed with high-fat diet (HFD) containing 20% of lard for 12 weeks to cause metabolic obesity. Subsequently, the animals were divided into six groups and were fed diets with lipid concentrations of 5% or 20% of lard (LD), soybean oil (SO) or fish oil (FO), for 4 weeks. Data were submitted to analysis of variance (two-way) followed by Tukey post hoc test (p < 0.05). The groups that consumed FO showed less weight gain and lower serum levels of triacylglycerol (TAG), total cholesterol and fractions, aspartate aminotransferase (AST) activity, atherogenic index, less amount of fat in the carcass, decreased Lee index and lower total leukocyte counting (p < 0.05). These same parameters were higher in LD treatment (p < 0.05). In the concentration of 20%, carcass fat content, blood glucose levels, as well as alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) decreased in FO groups (p < 0.05). The SO group had intermediate results regarding the other two treatments (FO and LD). We concluded that fish oil intake was able to modulate positively the metabolic changes resulting from HFD.
['Gondim|Paula Novato|PN|', 'Rosa|Priscila Vieira|PV|', 'Okamura|Daniel|D|', 'Silva|Viviam De Oliveira|VO|', 'Andrade|Eric Francelino|EF|0000-0002-9253-3108', 'Biihrer|Daniel Arrais|DA|', 'Pereira|Luciano José|LJ|0000-0002-0502-2554']
D050154:Adiposity D000410:Alanine Transaminase D000818:Animals D001219:Aspartate Aminotransferases D015415:Biomarkers D001786:Blood Glucose D059305:Diet, High-Fat D004041:Dietary Fats D004195:Disease Models, Animal D004734:Energy Metabolism D005395:Fish Oils D050356:Lipid Metabolism D008055:Lipids D008297:Male D009765:Obesity D017208:Rats, Wistar D013024:Soybean Oil D013997:Time Factors D015430:Weight Gain D005723:gamma-Glutamyltransferase
dietary fat metabolic syndrome n-3 fatty acids n-6 fatty acids plasma lipids polyunsaturated fatty acids (PUFA) saturated fatty acids