Hydrothermal Duodenal Mucosal Resurfacing: Role in the Treatment of Metabolic Disease.
The duodenum has become recognized as a metabolic signaling center that is involved in regulating insulin action and, therefore, insulin resistance states such as type 2 diabetes. Bariatric surgery and other manipulations of the upper intestine, in particular the duodenum, have shown that limiting nutrient exposure or contact in this key region exerts powerful metabolic effects. Early human clinical trial data suggest that endoscopic hydrothermal duodenal mucosal resurfacing is well tolerated in human subjects and has an acceptable safety profile. This article describes the rationale for this endoscopic approach and its early human use, including safety, tolerability, and early efficacy.
['Cherrington|Alan D|AD|', 'Rajagopalan|Harith|H|', 'Maggs|David|D|', 'Devière|Jacques|J|']
D050110:Bariatric Surgery D017115:Catheter Ablation D003924:Diabetes Mellitus, Type 2 D004384:Duodenoscopy D004386:Duodenum D005234:Fatty Liver D006801:Humans D007333:Insulin Resistance D007413:Intestinal Mucosa D024821:Metabolic Syndrome
Duodenal mucosal resurfacing Metabolic disease Duodenum Insulin resistance Type 2 diabetes Endoscopic treatment Hydrothermal ablation Nonalcoholic fatty liver disease