Rapid rest/stress regadenoson ungated perfusion CMR for detection of coronary artery disease in patients with atrial fibrillation.
Cardiovascular magnetic resonance (CMR) perfusion has been established as a useful imaging modality for the detection of coronary artery disease (CAD). However, there are several limitations when applying standard, ECG-gated stress/rest perfusion CMR to patients with atrial fibrillation (AF). In this study we investigate an approach with no ECG gating and a rapid rest/stress perfusion protocol to determine its accuracy for detection of CAD in patients with AF. 26 patients with AF underwent a rapid rest/regadenoson stress CMR perfusion imaging protocol, and all patients had X-ray coronary angiography. An ungated radial myocardial perfusion sequence was used. Imaging protocol included: rest perfusion image acquisition, followed nearly immediately by administration of regadenoson to induce hyperemia, 60 s wait, and stress image acquisition. CMR perfusion images were interpreted by three blinded readers as normal or abnormal. Diagnostic accuracy was evaluated by comparison to X-ray angiography. 21 of the CMR rest/stress perfusion scans were negative, and 5 were positive by angiography criteria. Majority results of the ungated datasets from all of the readers showed a sensitivity, specificity and accuracy of 80, 100 and 96%, respectively, for detection of CAD. An ungated, rapid rest/stress regadenoson perfusion CMR protocol appears to be useful for the diagnosis of obstructive CAD in patients with AF.
['Bieging|Erik T|ET|', 'Haider|I|I|', 'Adluru|G|G|', 'Chang|L|L|', 'Suksaranjit|P|P|', 'Likhite|D|D|', 'Shaaban|A|A|', 'Jensen|L|L|', 'Wilson|B D|BD|', 'McGann|C J|CJ|', 'DiBella|E|E|']
D000368:Aged D000369:Aged, 80 and over D001281:Atrial Fibrillation D017023:Coronary Angiography D003324:Coronary Artery Disease D003326:Coronary Circulation D005260:Female D006339:Heart Rate D006801:Humans D006940:Hyperemia D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D055414:Myocardial Perfusion Imaging D011237:Predictive Value of Tests D011687:Purines D011720:Pyrazoles D015203:Reproducibility of Results D013997:Time Factors D014665:Vasodilator Agents
Atrial fibrillation ECG gating Cardiac perfusion Myocardial perfusion imaging Ungated cardiac MR