Mesothelial Cysts.
OBJECTIVES
Peritoneal mesothelial cysts have been reported under various terms, including benign cystic mesothelioma, usually in the form of case reports/series, whereas extraperitoneal cases are rarely reported. Our objective was to report the detailed characteristics of cystic lesions of the serosal cavities.


METHODS
We retrospectively examined the clinicopathologic findings of a series of mesothelial cystic lesions (n = 79).


RESULTS
Most cases (n = 68, 86%) concerned the peritoneum, whereas 11 (14%) concerned the pericardium. No pleural cases were found. A total of 51 (64.5%) lesions were solitary, whereas 28 (35.5%) were multiple. Peritoneal lesions harbored a plump eosinophilic mesothelium and a loose connective stroma, whereas pericardial lesions showed a cuboidal/flattened mesothelium, collagenous stroma, intense inflammation, and other tissue types, like adipose and muscle tissue. Solitary peritoneal lesions are usually extrapelvic and found in older patients incidentally during other surgeries, whereas multiple lesions are found in younger patients and usually in the pelvis. The lesions show a benign clinical course with rare recurrences but no malignant transformation.


CONCLUSIONS
Most mesothelial cysts are peritoneal and rarely pericardial. Peritoneal cysts differ from pericardial cysts. Peritoneal solitary lesions differ from multiple lesions, also suggesting their pathogenetic differences.
['Karpathiou|Georgia|G|', 'Casteillo|Francois|F|', 'Dridi|Maroa|M|', "Peoc'h|Michel|M|"]
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D002648:Child D003560:Cysts D004848:Epithelium D006801:Humans D008297:Male D008654:Mesothelioma D008875:Middle Aged D009364:Neoplasm Recurrence, Local D010388:Pelvis D010994:Pleura D012189:Retrospective Studies D055815:Young Adult
Cystic mesothelioma Peritoneal cyst Pericardial cyst Inclusion cyst Multicystic mesothelioma Multiloculated cyst Pleural cyst Pleuropericardial cyst