Estrogens in the wrong place at the wrong time: Fetal BPA exposure and mammary cancer.
Iatrogenic gestational exposure to diethylstilbestrol (DES) induced alterations of the genital tract and predisposed individuals to develop clear cell carcinoma of the vagina as well as breast cancer later in life. Gestational exposure of rodents to a related compound, the xenoestrogen bisphenol-A (BPA) increases the propensity to develop mammary cancer during adulthood, long after cessation of exposure. Exposure to BPA during gestation induces morphological alterations in both the stroma and the epithelium of the fetal mammary gland at 18 days of age. We postulate that the primary target of BPA is the fetal stroma, the only mammary tissue expressing estrogen receptors during fetal life. BPA would then alter the reciprocal stroma-epithelial interactions that mediate mammogenesis. In addition to this direct effect on the mammary gland, BPA is postulated to affect the hypothalamus and thus in turn affect the regulation of mammotropic hormones at puberty and beyond.
['Paulose|Tessie|T|', 'Speroni|Lucia|L|', 'Sonnenschein|Carlos|C|', 'Soto|Ana M|AM|']
D000367:Age Factors D000818:Animals D001559:Benzhydryl Compounds D001943:Breast Neoplasms D002450:Cell Communication D002471:Cell Transformation, Neoplastic D004305:Dose-Response Relationship, Drug D052244:Endocrine Disruptors D004847:Epithelial Cells D004967:Estrogens D005260:Female D005865:Gestational Age D006801:Humans D007031:Hypothalamus D008321:Mammary Glands, Animal D042361:Mammary Glands, Human D018811:Maternal Exposure D010636:Phenols D011247:Pregnancy D011297:Prenatal Exposure Delayed Effects D018570:Risk Assessment D012307:Risk Factors D017154:Stromal Cells
Xenoestrogens Fetal mammary gland Endocrine disruptors Environmental exposure Mammary gland development Prenatal exposure