Zwitterionic fusion in hydrogels and spontaneous and time-independent self-healing under physiological conditions.
The biomedical applications of current self-healing materials are largely impeded by their healing conditions, which usually require heating, UV exposure or harsh pH environments. At the same time, for very few existing spontaneously self-healing materials, healing can only be achieved immediately after rupture occurs. Here, we developed a spontaneously healing material, driven by a new mechanism, "zwitterionic fusion", which is repairable independent of time after damage under physiological conditions. We also tested the anti-fatigue property of this zwitterionic hydrogel. Furthermore, we utilized this zwitterionic fusion to link different cell-hydrogel constructs together.
['Bai|Tao|T|', 'Liu|Sijun|S|', 'Sun|Fang|F|', 'Sinclair|Andrew|A|', 'Zhang|Lei|L|', 'Shao|Qing|Q|', 'Jiang|Shaoyi|S|']
D000818:Animals D001672:Biocompatible Materials D019556:COS Cells D002448:Cell Adhesion D020100:Hydrogels D051379:Mice D008962:Models, Theoretical D041681:NIH 3T3 Cells
Zwitterionic Fusion Self-healing materials Time-independent behavior Zwitterionic materials