Long noncoding RNAs as a piece of polycystic ovary syndrome puzzle.
Polycystic ovary syndrome (PCOS) is an endocrine disorder and affects 5-10% of reproductive-age women. Chronic anovulation, polycystic ovaries, and hyperandrogenism are the important features of this syndrome. Furthermore, hyperinsulinemia and central obesity are frequent in PCOS women. In recent years, noncoding RNAs detection provided new ideas to explain the etiology of female reproductive disorders. Long noncoding RNAs (lncRNAs) as a subset of noncoding RNAs are associated with the pathogenesis of manifold reproductive-related disorders. Various investigations emphasized the potential involvement of lncRNAs in PCOS development. Therefore, in this paper, we will summarize the function of numerous lncRNAs in the apoptosis and proliferation of granulosa cells (GCs), insulin resistance (IR), and steroidogenesis in PCOS.
['Abolghasemi|Maryam|M|http://orcid.org/0000-0002-0390-8052', 'Mahjoub|Soleiman|S|http://orcid.org/0000-0002-9775-804X']
D000728:Androgens D000818:Animals D017209:Apoptosis D049109:Cell Proliferation D004967:Estrogens D005260:Female D006801:Humans D007328:Insulin D011085:Polycystic Ovary Syndrome D062085:RNA, Long Noncoding
Polycystic ovary syndrome Hyperandrogenism lncRNA Granulosa cell Insulin resistance