Malignancies in Children with Human Immunodeficiency Virus Infection - Our Experience at Chandigarh, North India.
Background
With improved survival in children living with human immunodeficiency virus (HIV) infection (CLHIV), malignancies are being increasingly recognized.


Patients and methods
Among the CLHIV registered at our institute from January 1994 to March 2015, children with malignancy were analysed in detail.


Results
In total, 734 children affected by HIV were registered. Out of these, 11 children (9 boys, 2 girls) were diagnosed to have malignancy. Malignancy was the presenting feature of HIV infection in 4 children. High-grade non-Hodgkin lymphoma (NHL) was the most common malignancy noted in 9 of 11 (81%) children, whereas the remaining 2 children had Hodgkin's lymphoma. Survival in our cohort was 80% among children in whom chemotherapy was initiated, and overall survival was 36% (4 of 11 children).


Conclusion
NHL was the most common malignancy in CLHIV in our cohort. Low-conditioning chemotherapy protocols along with initiation of anti-retroviral therapy resulted in improved outcomes in CLHIV with malignancy.
['Suri|Deepti|D|', 'Bhattad|Sagar|S|', 'Gupta|Anju|A|', 'Trehan|Amita|A|', 'Bansal|Deepak|D|', 'Rajwanshi|Arvind|A|', 'Das|Ashim|A|', 'Rawat|Amit|A|', 'Singh|Surjit|S|']
D000293:Adolescent D017677:Age Distribution D002648:Child D015331:Cohort Studies D005260:Female D015658:HIV Infections D006801:Humans D007194:India D016483:Lymphoma, AIDS-Related D008228:Lymphoma, Non-Hodgkin D008297:Male D008499:Medical Records D009369:Neoplasms D012307:Risk Factors D017678:Sex Distribution D015996:Survival Rate
malignancy HIV children. lymphoma cancer