Relation of ABO blood groups to the severity of coronary atherosclerosis: an Gensini score assessment.
OBJECTIVE
Although the study on the relationship between ABO blood groups and coronary atherosclerosis has a long history, few data is available regarding ABO to severity of coronary atherosclerosis in a large cohort study. Therefore, the present study aimed to investigate the relation of the ABO blood groups to the severity of coronary atherosclerosis assessed by Gensini score (GS) in a large Chinese cohort undergoing coronary angiography.


METHODS
A total of 2919 consecutive patients undergoing coronary angiography were enrolled, and their baseline characteristics and ABO blood groups were collected. The GS was calculated as 1st tertile (0-10), 2nd tertile (11-36), 3rd tertile (>36) according to angiographic results. The relation of the ABO blood groups to GS was investigated.


RESULTS
The frequency of blood group A was significantly higher in the upper GS tertiles (24.4% vs. 28.2% vs. 29.5%, p = 0.032). Multivariable linear regression analysis revealed that blood group A was independently associated with GS (β = 0.043, p = 0.017). Likewise, multivariable logistic regression analysis showed that group A remained significantly associated with mid-high GS (OR = 1.44, 95% CI 1.16-1.80, p = 0.001), and the group O was showed as a protective factor (OR = 0.77, 95% CI = 0.65-0.92, p = 0.004).


CONCLUSION
In this large Chinese cohort study, the data indicated that there was an association between ABO blood groups and the severity of coronary atherosclerosis. Moreover, the blood group A was an independent risk factor for serious coronary atherosclerosis.
['Gong|Ping|P|', 'Luo|Song-Hui|SH|', 'Li|Xiao-Lin|XL|', 'Guo|Yuan-Lin|YL|', 'Zhu|Cheng-Gang|CG|', 'Xu|Rui-Xia|RX|', 'Li|Sha|S|', 'Dong|Qian|Q|', 'Liu|Geng|G|', 'Chen|Juan|J|', 'Zeng|Rui-Xiang|RX|', 'Li|Jian-Jun|JJ|']
D000017:ABO Blood-Group System D000368:Aged D001786:Blood Glucose D002681:China D015331:Cohort Studies D017023:Coronary Angiography D003324:Coronary Artery Disease D003430:Cross-Sectional Studies D005260:Female D006801:Humans D007249:Inflammation D016014:Linear Models D008297:Male D008875:Middle Aged D015999:Multivariate Analysis D015995:Prevalence D012307:Risk Factors D012720:Severity of Illness Index D014280:Triglycerides
ABO blood group Coronary atherosclerosis Gensini score Risk factor