Does C60 fullerene act as a transporter of small aromatic molecules?
C60 fullerene is reported to directly interact with biomolecules, such as aromatic mutagens or anticancer drugs. Therefore, it is extensively studied for its potential application in the fields of drug delivery and chemoprevention. Understanding the nature of fullerene-drugs interactions might contribute to optimization and modification of the existing chemotherapy systems. Possible interactions between ICR-191, a model acridine mutagen, with well-established biophysical properties and mutagenic activity, and C60 fullerene aqueous solution were investigated by broad range of biophysical methods, such as Dynamic Light Scattering, Isothermal Titration Calorimetry, and Atomic Force Microscopy. Additionally, to determine biological activity of ICR-191-C60 fullerene mixtures, Ames mutagenicity test was employed. It was demonstrated that C60 fullerene interacts non-covalently with ICR-191 and has strong affinity to bacterial membranes. The obtained results provide practical insight into C60 fullerene interactions with aromatic compounds.
['Borowik|Agnieszka|A|', 'Prylutskyy|Yuriy|Y|', 'Kawelski|Łukasz|Ł|', 'Kyzyma|Olena|O|', 'Bulavin|Leonid|L|', 'Ivankov|Oleksandr|O|', 'Cherepanov|Vsevolod|V|', 'Wyrzykowski|Dariusz|D|', 'Kaźmierkiewicz|Rajmund|R|', 'Gołuński|Grzegorz|G|', 'Woziwodzka|Anna|A|', 'Evstigneev|Maxim|M|', 'Ritter|Uwe|U|', 'Piosik|Jacek|J|']
D000585:Aminacrine D001692:Biological Transport D055592:Biophysical Phenomena D037741:Fullerenes D006841:Hydrocarbons, Aromatic D018625:Microscopy, Atomic Force D008958:Models, Molecular D009153:Mutagens D009588:Nitrogen Mustard Compounds D012486:Salmonella typhimurium
AFM Direct interactions Nanocarriers Nanoparticles