Expression pattern of Connexin 26 and Connexin 30 in mature cochlea of the monkey.
Connexin26 (Cx26) and Cx30 are the predominant connexin subtypes found in the cochlea. They play an essential role in the cochlear functions. However, most studies use mice and the data on the cochlear expression profiles of the two Cxs in higher animals (e.g., humans) are scarce. Studies using the cochleae from non-human primate other than mice may provide information needed to narrow this gap. Here we studied cellular distributions of Cx26 and Cx30 in the adult monkey and guinea pig cochleae by immunofluorescent labeling and confocal microscopy observations. We detected Cx26 and Cx30 expressions in the type I, II& V fibrocytes in the spiral ligament, fibrocytes of the spiral limbus, in the supporting cells of organ of Corti, inner and outer sulcus cells, and in the basal cells of the stria vascularis. Both Cx26 and Cx30 were not detected in hair cells, in mesenchymal cells under the basilar membrane and cells lining the scala vestibule. Cells of the Reissner's membrane and spiral ganglion neurons are also negative. These findings demonstrate that cochlear expressions of Cx26 and Cx30 in the adult mouse, guinea pig and non-human primate have a common cellular pattern.
['Wu|Xuewen|X|', 'Tang|Wenxue|W|', 'Muly|Emil C|EC|', 'Zhang|Li|L|', 'Lin|Xi|X|']
D000818:Animals D003051:Cochlea D000072259:Connexin 26 D000075302:Connexin 30 D017629:Gap Junctions D006168:Guinea Pigs D008253:Macaca mulatta D008297:Male D018613:Microscopy, Confocal
Connexin Cochlea Monkey Guinea pig Gap junction