Eosinophilic esophagitis: interactions with gastroesophageal reflux disease.
Gastroesophageal reflux disease (GERD) and eosinophilic esophagitis (EoE) are not mutually exclusive. The notion that GERD and EoE can be distinguished by the response to proton pump inhibitor (PPI) treatment is based on the mistaken assumption that gastric acid suppression is the only important therapeutic effect of PPIs, and therefore only GERD can respond to PPIs. We believe that a clinical or histologic response to PPIs does not rule in GERD or rule out EoE. We recommend a trial of PPI therapy for patients with symptomatic esophageal eosinophilia, even if the diagnosis of EoE seems clear-cut.
['Cheng|Edaire|E|', 'Souza|Rhonda F|RF|', 'Spechler|Stuart Jon|SJ|']
D057765:Eosinophilic Esophagitis D005764:Gastroesophageal Reflux D006801:Humans D054328:Proton Pump Inhibitors
Eosinophilic esophagitis Gastroesophageal reflux disease Proton pump inhibitors PPI-responsive esophageal eosinophilia