Recurrent multiple neurofibromatosis type  1 of the right lower limb.
Neurofibromatosis type 1 is an autosomal dominant inherited disease, which is characterized by the presence of multiple neurofibromas. We encountered a case in which a sporadic dispersed neurofibroma recurred locally on numerous occasions extending over 16 years. The patient developed multiple masses with a focus of neurofibroma on the right lower limb, which were excised. The patient was initially diagnosed with inflammatory changes via computed tomography and magnetic resonance imaging; however, subsequently, pathological and immunohistochemical examinations revealed an intraneural neurofibroma. The patient underwent a comprehensive and complete local resection several times. After a continuous postoperative follow-up strategy, the patient recovered well. This report describes a case of primary manifestations of multiple and recurrent neurofibromas. We aim to emphasize the possibility of a unique, recurrent, non-healing neurofibroma and review the diagnostic techniques utilized to reach a definitive diagnosis. Early and complete surgical resection is an effective method to treat and prevent this type of neurofibroma.
['Huang|Leitao|L|', 'Wu|Xia|X|', 'Ding|Yi|Y|', 'Qi|Lai|L|', 'Li|Wei|W|', 'Huang|Gendong|G|', 'Dai|Min|M|', 'Zhang|Bin|B|']
D000328:Adult D001706:Biopsy D003646:Debridement D006801:Humans D007150:Immunohistochemistry D007866:Leg D008279:Magnetic Resonance Imaging D008297:Male D019042:Muscle Neoplasms D009364:Neoplasm Recurrence, Local D009378:Neoplasms, Multiple Primary D009456:Neurofibromatosis 1 D012086:Reoperation D012983:Soft Tissue Neoplasms D014057:Tomography, X-Ray Computed
Recurrence Neurofibroma Computed tomography Case study Surgery