The role of HHV-6 and HHV-7 infections in the development of fibromyalgia.
Human herpes virus-6 (HHV-6) and human herpes virus-7 (HHV-7) are immunomodulating viruses potentially affecting the nervous system. We evaluated the influence of HHV-6 and HHV-7 infections on fibromyalgia (FM) clinical course. Forty-three FM patients and 50 control group participants were enrolled. 39.50% (n = 17) FM patients had light A delta and C nerve fiber damage, 27.91% (n = 12) had severe A delta and C nerve fiber damage. 67.44% (n = 29) FM patients had loss of warm sensation in feet, loss of heat pain sensation, and increased cold pain sensation (34.90%, n = 15 in both findings). HHV-6 and HHV-7 genomic sequences in peripheral blood DNA in 23/43 (51.00%) and 34/43 (75.50%) of samples from FM patients and in 3/50 (6.00%) and 26/50 (52.00%) of samples from the control group individuals were detected. Active HHV-6 (plasma viremia) or HHV-7 infection was revealed only in FM patients (4/23, 17.40% and 4/34, 11.80%, respectively). A statistically significant moderate positive correlation was found between A delta and C nerve fiber damage severity and HHV-6 infection (p < 0.01, r = 0.410). 23/43 patients from the FM group and control group participants HHV-6 and 34/45 HHV-7 did have infection markers. A statistically significant moderate positive correlation was found between A delta and C nerve fiber damage severity and HHV-6 infection (p < 0.01, r = 0.410). No difference was found between detection frequency of persistent HHV-6 and HHV-7 infection between FM patients and the control group. Statistically significant correlation was observed between quantitation of changes in QST thermal modalities and HHV-6 infection. There was no correlation between A delta and C nerve fiber damage and HHV-7 infection.
['Krumina|Angelika|A|0000-0003-0726-3375', 'Chapenko|Svetlana|S|', 'Kenina|Viktorija|V|', 'Mihailova|Marija|M|', 'Logina|Inara|I|', 'Rasa|Santa|S|', 'Gintere|Sandra|S|', 'Viksna|Ludmila|L|', 'Svirskis|Simons|S|', 'Murovska|Modra|M|']
D000328:Adult D000368:Aged D016022:Case-Control Studies D005260:Female D005356:Fibromyalgia D015654:Herpesvirus 6, Human D016199:Herpesvirus 7, Human D006801:Humans D008297:Male D008875:Middle Aged D010146:Pain D010147:Pain Measurement D019349:Roseolovirus Infections D012720:Severity of Illness Index D019562:Viral Load D014766:Viremia
HHV-6 HHV-7 Fibromyalgia