Septal flash: At the heart of cardiac dyssynchrony.
Cardiac resynchronization therapy (CRT) has been a major step in the treatment of heart failure patients and intraventricular conduction delay. As a considerable number of patients do not respond adequately to CRT, echocardiographic dyssynchrony selection criteria have been proposed to improve CRT response, but these parameters eventually failed to provide superior selection of CRT candidates. In the last decade, an echo-dyssynchrony parameter called "septal flash" was been reported by several investigators and opinion leaders in the field of CRT. This parameter has a strong pathophysiological rationale and was shown to be a robust and predominant predictor of CRT response in recent observational and retrospective studies. We here provide a comprehensive and balanced overview of septal flash and address several important aspects, questions and potential future implications of septal flash in cardiomyopathy and CRT.
['Calle|Simon|S|', 'Delens|Christophe|C|', 'Kamoen|Victor|V|', 'De Pooter|Jan|J|', 'Timmermans|Frank|F|']
D000200:Action Potentials D000818:Animals D002037:Bundle-Branch Block D058406:Cardiac Resynchronization Therapy D058409:Cardiac Resynchronization Therapy Devices D000066491:Clinical Decision-Making D006333:Heart Failure D006339:Heart Rate D006346:Heart Septum D006801:Humans D020127:Recovery of Function D016896:Treatment Outcome D018487:Ventricular Dysfunction, Left D016277:Ventricular Function, Left D020257:Ventricular Remodeling
Septal flash Cardiac dyssynchrony Cardiac resynchronization therapy Left bundle branch block