Thyroid hormones in extreme longevity.
The aim of the present review was to summarize knowledge about thyroid hormones (THs) and longevity. Longevity is a complex multifactorial phenomenon on which specific biological pathways, including hormonal networks involved in the regulation of homeostasis and survival, exert a strong impact. THs are the key responsible for growth, metabolism rate and energy expenditure, and help in maintaining cognition, bone and cardiovascular health. THs production and metabolism are fine tuned, and may help the organism to cope with a variety of environmental challenges. Experimental evidence suggests that hypothyroid state may favor longevity by reducing metabolism rate, oxidative stress and cell senescence. Data from human studies involving healthy subjects and centenarians seem to confirm this view, but THs changes observed in older patients affected by chronic diseases cannot be always interpreted as a protective adaptive mechanism aimed at reducing catabolism and prolonging survival. Medications, selected chronic diseases and multi-morbidity can interfere with thyroid function, and their impact is still to be elucidated.
['Garasto|Sabrina|S|', 'Montesanto|Alberto|A|', 'Corsonello|Andrea|A|', 'Lattanzio|Fabrizia|F|', 'Fusco|Sergio|S|', 'Passarino|Giuseppe|G|', 'Prestipino Giarritta|Valeria|V|', 'Corica|Francesco|F|']
D000369:Aged, 80 and over D005260:Female D006801:Humans D007037:Hypothyroidism D008136:Longevity D008297:Male D018384:Oxidative Stress D013963:Thyroid Hormones
Thyroid Longevity Centenarians Age-related diseases Aging