TAM receptors and their ligand-mediated activation: Role in atherosclerosis.
TAM family tyrosine kinase receptors including Tyro3, Axl, and MerTK are the key efferocytosis receptors presenting on antigen-presenting cell that mediate the clearance of apoptotic cells. They are thought to regulate inflammatory diseases by modulating inflammatory response and efferocytosis. Recent studies have revealed novel roles of TAM receptors in the biosynthesis of specialized pro-resolving mediators (SPMs) and inflammation resolution. In this chapter, we discuss the central roles of TAM signaling in atherosclerosis focusing on their regulation in efferocytosis and inflammation resolution and highlight the unique therapeutic potential of SPMs in blocking the progression of atherosclerosis.
['Cai|Bishuang|B|', 'Kasikara|Canan|C|']
D000818:Animals D050197:Atherosclerosis D006801:Humans D008024:Ligands D011518:Proto-Oncogene Proteins D020794:Receptor Protein-Tyrosine Kinases D000076202:c-Mer Tyrosine Kinase
TAM Atherosclerosis Efferocytosis Specialized pro-resolving mediators Inflammation resolution MerTK cleavage