Increased levels of MMP-3, MMP-9 and MPO represent predictors of in-stent restenosis, while increased levels of ADMA, LCAT, ApoE and ApoD predict bare metal stent patency.
AIMS
We sought to identify biochemical predictors that indicate susceptibility to in-stent restenosis (ISR) after coronary artery bare-metal stenting.


METHODS
A total of 111 consecutive patients with post-percutaneous coronary intervention (PCI) in-stent restenosis of a target lesion within 12 months were matched for age, sex, vessel diameter, and diabetes with 111 controls without post-PCI ISR. Plasma or serum levels of biochemical markers were measured: matrix metalloproteinases (MMP) 2, 3, 9; myeloperoxidase (MPO); asymmetric dimethylarginine (ADMA); lipoprotein (a) (Lp[a]); apolipoproteins E and D (ApoE and D); and lecitin-cholesterol acyltransferase (LCAT). Multivariable logistic regression association tests were performed.


RESULTS
Increased plasma MMP-3 (OR: 1.013; 95% CI: 1.004-1.023; P = 0.005), MMP-9 (OR: 1.014; 95% CI: 1.008-1.020; P < 0.0001) or MPO (OR: 1,003; 95% CI: 1.001-1.005; P = 0.002) was significantly associated with increased risk of ISR. Increased levels of ADMA (OR: 0.212; 95% CI: 0.054-0.827; P = 0.026), ApoE (OR: 0.924; 95% CI: 0.899-0.951; P < 0.0001), ApoD (OR: 0.919; 95% CI: 0.880-0.959; P = 0.0001), or LCAT (OR: 0.927; 95% CI: 0.902-0.952; P < 0.0001) was associated with risk reduction. No correlation was found between plasma MMP-2 or Lp (a) and ISR risk.


CONCLUSIONS
Increased levels of MMP-3, MMP-9, and MPO represent predictors of ISR after bare-metal stent implantation. In contrast, increased ADMA, LCAT, and Apo E and D indicate a decreased in-stent restenosis occurrence.
['Pleva|Leos|L|', 'Kusnierova|Pavlina|P|', 'Plevova|Pavlina|P|', 'Zapletalova|Jana|J|', 'Karpisek|Michal|M|', 'Faldynova|Lucie|L|', 'Kovarova|Petra|P|', 'Kukla|Pavel|P|']
D000368:Aged D053399:Apolipoproteins D D001057:Apolipoproteins E D001120:Arginine D015415:Biomarkers D016022:Case-Control Studies D023903:Coronary Restenosis D005260:Female D006083:Graft Occlusion, Vascular D006801:Humans D017270:Lipoprotein(a) D008297:Male D019278:Matrix Metalloproteinase 3 D020780:Matrix Metalloproteinase 9 D008875:Middle Aged D062645:Percutaneous Coronary Intervention D009195:Peroxidase D007862:Phosphatidylcholine-Sterol O-Acyltransferase D015607:Stents D014654:Vascular Patency
in-stent restenosis matrix metalloproteinases myeloperoxidase asymmetric dimethylarginine apolipoproteins E lecitin-cholesterol acyltransferase apolipoproteins D