Propensity score-matched study and meta-analysis of cumulative outcomes of day 2/3 versus day 5/6 embryo transfers.
The superiority of the cumulative outcomes of day 5/6 embryo transfer to those of day 2/3 embryo transfer in infertile couples has been debated. This retrospective study included data collected from 1051 patients from July 2011 to June 2014. Multiple maternal baseline covariates were subjected to propensity score matching analysis, and each day 5/6 group woman was matched to one day 2/3 group woman. A systematic meta-analysis was conducted to validate the results. After matching was completed, 217 patients on the day 2/3 group were matched with those on the day 5/6 group, and no significant differences in the baseline characteristics were observed between the two groups. The cumulative pregnancy rate (57.14% vs. 53.46%, OR 1.16, 95% CI 0.79-1.70) and cumulative live birth rate (53.00% vs. 49.77%, OR 1.14, 95% CI 0.78-1.66) of day 5/6 embryo transfers were higher than those of day 2/3 embryo transfers, but this difference was not significant. The mean cycles per live birth and mean days per live birth in the day 5/6 group were significantly lower than those in the day 2/3 group. This study demonstrated that day 5/6 embryo transfer is a more cost-effective and time-efficient policy than day 2/3 embryo transfer to produce a live baby.
['Yin|Ye|Y|', 'Chen|Ge|G|', 'Li|Kezhen|K|', 'Liao|Qiuyue|Q|', 'Zhang|Sijia|S|', 'Ma|Nieying|N|', 'Chen|Jing|J|', 'Zhang|Yan|Y|', 'Ai|Jihui|J|']
D000328:Adult D002681:China D002970:Cleavage Stage, Ovum D015331:Cohort Studies D004624:Embryo Transfer D005260:Female D005307:Fertilization in Vitro D006801:Humans D007246:Infertility D050498:Live Birth D008297:Male D011247:Pregnancy D011256:Pregnancy Outcome D018873:Pregnancy Rate D057216:Propensity Score D012189:Retrospective Studies
embryo transfer cumulative pregnancy rate cumulative live birth rate IVF blastocyst