Identification and Characterization of Salmonella enterica Serotype Newport Isolates with Decreased Susceptibility to Ciprofloxacin in the United States.
Nontyphoidal Salmonella (NTS) causes an estimated 1.2 million illnesses, 23,000 hospitalizations, and 450 deaths each year in the United States. Decreased susceptibility to ciprofloxacin (DSC) has historically been associated with chromosomal mutations of the quinolone resistance determining region (QRDR), but plasmid-mediated quinolone resistance (PMQR) genes are increasing. To investigate DSC among Salmonella enterica serotype Newport strains, we examined 40 isolates from 1996 to 2016 with DSC. Thirty isolates (71%) contained the PMQR gene qnrB and eight isolates (19%) contained a QRDR.
['Campbell|D|D|', 'Tagg|K|K|', 'Bicknese|A|A|', 'McCullough|A|A|', 'Chen|J|J|', 'Karp|B E|BE|', 'Folster|J P|JP|']
D000900:Anti-Bacterial Agents D001426:Bacterial Proteins D002939:Ciprofloxacin D008826:Microbial Sensitivity Tests D010957:Plasmids D015363:Quinolones D019779:Salmonella enterica D065288:Serogroup D014481:United States
Salmonella antibiotic resistance