Double dispersant-assisted ionic liquid dispersive liquid-liquid microextraction coupled with capillary electrophoresis for the determination of benzophenone-type ultraviolet filters in sunscreen cosmetic product.
In this work, double dispersant-assisted ionic liquid dispersive liquid-liquid microextraction coupled with micellar electrokinetic chromatography was developed to determine four UV filters (benzophenone, 4-hydroxybenzophenone, 2,4-dihydroxybenzophenone, and 2-hydroxy-4-methoxybenzophenone). 1-Hexyl-3-methylimidazolium hexafluorophosphate was used as the extraction solvent. The main novelty of the present work was that acetonitrile-Triton X-114 was used as double disperser solvent. Parameters affected the extraction efficiency were investigated and optimized. Under the optimum conditions, enrichment factors were in the range of 25.3-40.5. The limits of detection and quantitation, calculated at a S/N of three and ten, were 3.9-6.7 ng/mL and 13.0-22.3 ng/mL. The linearity of the method was in the range of 0.02-2 μg/mL for 2, 4-dihydroxybenzophenone and 4-hydroxybenzophenone, 0.01-2 μg/mL for benzophenone and 2-hydroxy-4-methoxybenzophenone, with correlation coefficient (R(2)) of 0.9984-0.9991. The proposed method was successfully applied to the determination of four benzophenone-type UV filters in six kinds of sunscreen cosmetic products, with yielded relative recoveries ranging from 80.2 to 117.7%.
['Ma|Teng|T|', 'Li|Zheng|Z|', 'Niu|Qian|Q|', 'Li|Yuanyuan|Y|', 'Zhou|Weihong|W|']
D001577:Benzophenones D002498:Centrifugation D003358:Cosmetics D019075:Electrophoresis, Capillary D006863:Hydrogen-Ion Concentration D007093:Imidazoles D052578:Ionic Liquids D057230:Limit of Detection D016014:Linear Models D059627:Liquid Phase Microextraction D015203:Reproducibility of Results D013473:Sunscreening Agents D013501:Surface-Active Agents
Benzophenone-type ultraviolet filters Sunscreen cosmetic product Micellar electrokinetic chromatography Double dispersant-assisted extraction Ionic liquid liquid-liquid microextraction