Primary sarcomas of the salivary glands: case series and literature review.
BACKGROUND
Mesenchymal malignancies of salivary origin are rare and are histologically diverse. We reviewed our experience with these tumors, as well as the published literature, with an emphasis on treatment modalities and prognosis.


METHODS
We identified 17 patients treated for malignant mesenchymal cell tumors at The University of Texas MD Anderson Cancer Center between 1990 and 2007. We compared our results to the literature from January 1990 to July 2010.


RESULTS
Tumors were located primarily in the parotid gland and were primarily T1 tumors (<5 cm). All patients were treated with surgical resection, and 13 patients were given adjuvant therapy. Seven patients (41%) had recurrence, and 4 developed distant metastases. The overall 5-year and 10-year survival rates were 42% and 20%, respectively.


CONCLUSIONS
Our case series and literature review show that sarcomas of the salivary glands have a high rate of recurrence and are associated with a poor prognosis.
['Cockerill|Cara C|CC|', 'Daram|Shiva|S|', 'El-Naggar|Adel K|AK|', 'Hanna|Ehab Y|EY|', 'Weber|Randal S|RS|', 'Kupferman|Michael E|ME|']
D000046:Academic Medical Centers D000328:Adult D000368:Aged D001707:Biopsy, Needle D002173:Cancer Care Facilities D003131:Combined Modality Therapy D016208:Databases, Factual D018572:Disease-Free Survival D005260:Female D006801:Humans D007150:Immunohistochemistry D008297:Male D008875:Middle Aged D009361:Neoplasm Invasiveness D009364:Neoplasm Recurrence, Local D009367:Neoplasm Staging D010307:Parotid Neoplasms D011379:Prognosis D018714:Radiotherapy, Adjuvant D035583:Rare Diseases D012468:Salivary Gland Neoplasms D012469:Salivary Glands D012494:Sampling Studies D012509:Sarcoma D016019:Survival Analysis D055815:Young Adult
sarcoma salivary gland mesenchymal parotid surgery