Prognostic value of cerebrospinal fluid neurofilament light chain and chitinase-3-like-1 in newly diagnosed patients with multiple sclerosis.
BACKGROUND
Neurofilament light chain (NFL) and chitinase-3-like-1 (CHI3L1) concentrations in cerebrospinal fluid (CSF) may have prognostic value in clinically isolated syndromes (CIS) and relapsing-remitting multiple sclerosis (RRMS).


OBJECTIVES
To compare the prognostic value of CSF concentrations of NFL and CHI3L1 in newly diagnosed CIS and RRMS patients.


METHODS
NFL and CHI3L1 were measured in CSF in 177 newly diagnosed patients with CIS or RRMS who were followed clinically for a mean of 5.7 years.


RESULTS
At baseline CSF concentrations of NFL correlated with CSF concentrations of CHI3L1, relapses in the previous year, time from last relapse, and the Expanded Disability Status Scale (EDSS) score. CSF concentrations of NFL and CHI3L1 were both associated with increased relapse risk during the first 2 years in univariate analyses, but only the CSF concentration of NFL was independently associated with relapse risk in a multivariable analysis. There was no relationship between CSF concentrations of NFL or CHI3L1 and risk of conversion to secondary progressive MS or development of disability.


CONCLUSION
CSF concentrations of NFL are associated with 2-year relapse risk but not with disease progression or clinical worsening in newly diagnosed CIS and RRMS patients. This may be due to confounding by the effect of disease-modifying therapies.
['Sellebjerg|Finn|F|', 'Royen|Lydia|L|', 'Soelberg Sørensen|Per|P|', 'Oturai|Annette Bang|AB|', 'Jensen|Poul Erik Hyldgaard|PEH|']
D000328:Adult D015415:Biomarkers D000071451:Chitinase-3-Like Protein 1 D003711:Demyelinating Diseases D018450:Disease Progression D005260:Female D006801:Humans D008297:Male D020528:Multiple Sclerosis, Chronic Progressive D020529:Multiple Sclerosis, Relapsing-Remitting D016900:Neurofilament Proteins D011379:Prognosis
disease-modifying therapies Biomarkers treatment response