Updates on Genome-Wide Association Findings in Eating Disorders and Future Application to Precision Medicine.
Heterogeneity, frequent diagnostic fluctuation across presentations, and global concerns with the absence of effective treatments all encourage science that moves the field toward individualized or precision medicine in eating disorders. We review recent advances in psychiatric genetics focusing on genome-wide association studies (GWAS) in eating disorders. Given that the only eating disorder to be the subject of GWAS to date is anorexia nervosa, we review anorexia GWAS and enumerate the prospects and challenges of a genomics-driven approach towards personalized intervention in eating disorders.
['Breithaupt|Lauren|L|', 'Hubel|Christopher|C|', 'Bulik|Cynthia M|CM|']
D001068:Feeding and Eating Disorders D020022:Genetic Predisposition to Disease D006801:Humans D057285:Precision Medicine
Eating disorders heterogeneity genetics GWAS anorexia nervosa heritability pathways polygenic risk score.