Muscle-derived Myoglianin regulates Drosophila imaginal disc growth.
Organ growth and size are finely tuned by intrinsic and extrinsic signaling molecules. In Drosophila, the BMP family member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen to regulate pattern and growth by diffusing throughout imaginal discs. However, the role of TGFβ/Activin-like ligands in disc growth control remains ill-defined. Here, we demonstrate that Myoglianin (Myo), an Activin family member, and a close homolog of mammalian Myostatin (Mstn), is a muscle-derived extrinsic factor that uses canonical dSmad2-mediated signaling to regulate wing size. We propose that Myo is a myokine that helps mediate an allometric relationship between muscles and their associated appendages.
['Upadhyay|Ambuj|A|', 'Peterson|Aidan J|AJ|0000-0002-6801-3364', 'Kim|Myung-Jun|MJ|', "O'Connor|Michael B|MB|0000-0002-3067-5506"]
D000818:Animals D029721:Drosophila Proteins D004331:Drosophila melanogaster D060227:Imaginal Discs D007814:Larva D009132:Muscles D015398:Signal Transduction D051896:Smad Proteins, Receptor-Regulated D016212:Transforming Growth Factor beta
Myoglianin imaginal disc Myostatin D. melanogaster developmental biology growth factors muscle fiber tgf beta