Association Between Celiac Disease and Cancer.
Celiac disease (CD) is a chronic enteropathy that develops in genetically susceptible individuals after the ingestion of gluten. There has been a substantial increase in CD prevalence in the last 50 years, and it is now estimated that this disease affects approximately 1% of the population in the Western world. In the large majority of cases, CD is a benign disease, characterized by the complete resolution of symptoms and a normal life expectancy after the onset of a gluten-free diet (GFD). However, failure to adhere to a strict GFD bears the risk of adverse events and increases mortality. A considerable number of studies have considered the possible association between CD and neoplasms. In particular, an increased risk of malignancies, such as cancers of the gastrointestinal tract and intestinal lymphomas, has been reported. In this review, we summarize and discuss the current evidence on the possible association between CD and cancer.
['Marafini|Irene|I|', 'Monteleone|Giovanni|G|', 'Stolfi|Carmine|C|0000-0002-6354-2443']
D002446:Celiac Disease D055050:Diet, Gluten-Free D005770:Gastrointestinal Neoplasms D006801:Humans D008232:Lymphoproliferative Disorders D009369:Neoplasms
gluten gluten-free diet HLA-DQ2 HLA-DQ8 T-cell lymphoma colorectal cancer refractory celiac disease small bowel adenocarcinoma