Cancer and inflammatory bowel disease in the elderly.
Cancer may be a complication of inflammatory bowel disease (IBD) or its treatments. In older Crohn's disease and ulcerative colitis patients, the risk of malignancy is of particular concern. IBD diagnosis at an advanced age is associated with earlier development of colitis-associated colorectal cancer. Thiopurine use in older IBD patients is tied to an increased risk of non-Hodgkin's lymphoma, nonmelanoma skin cancer, and urinary tract cancers. Additionally, older age is accompanied by multimorbidity, an increased risk of malnutrition, and decreased life expectancy, factors that complicate the management of cancer in the elderly. The optimal approach to the increased risk of malignancy in older age IBD is appropriate cancer screening and medical treatment. This may include age-specific colorectal cancer screening and limiting UV radiation exposure. With a growing number of older IBD patients, further studies are necessary to delineate the risk of cancer in this population.
['Taleban|Sasha|S|', 'Elquza|Emad|E|', 'Gower-Rousseau|Corinne|C|', 'Peyrin-Biroulet|Laurent|L|']
D000367:Age Factors D000368:Aged D015179:Colorectal Neoplasms D055088:Early Detection of Cancer D006801:Humans D015212:Inflammatory Bowel Diseases D008228:Lymphoma, Non-Hodgkin D015122:Mercaptopurine D012878:Skin Neoplasms D014571:Urologic Neoplasms
Older Crohn's disease Ulcerative colitis Malignancy