Duodenal diverted sleeve gastrectomy with ileal interposition does not cause biliary salt malabsorption.
BACKGROUND
Duodenal diverted sleeve gastrectomy with ileal interposition (DDSG-II) is a bariatric-metabolic operation designed to treat type 2 diabetes mellitus (T2DM). It is restrictive (SG) but also acts on the small bowel with functional effects. The objective of the present study was to investigate whether or not it is also a malabsorptive operation.


METHODS
Twelve obese patients (9 female and 3 male) affected by T2DM had DDSG-II. Follow-up was every 3 months, and the results after 1 year are reported here. Clinical conditions, related to diabetes and malnutrition, changes in weight, body mass index, fasting glucose plasma levels, HbA1c (glycated hemoglobin %), basal insulin, vitamin B12, folic acid, vitamin D, total proteins, albumin, and hemoglobin were recorded. Basal plasma levels of FGF19 (pg/mL) and of 7α-hydroxy-4-cholesten-3-one (C4) (μg/dL) were also determined for the diagnosis of biliary salt malabsorption. The results were expressed as mean±SEM, and the differences between times compared by the Mann Whitney U test; P<.05 was considered significant.


RESULTS
After 1 year, all patients had a significant weight loss (-33.2±3 kg) with T2DM remission according to the American Diabetes Association criteria (11), criteria. No significant changes in total proteins, albumin, hemoglobin, and vitamins (B6, B12, and D) were detected. C4 did not change after the operation (2±.5 µg/dL versus 1.6±.5 µg/dL), whereas FGF19 significantly increased (from 85±11.2 pg/mL to 166.4±28.2 pg/mL, P<.04). Only 2 patients had mild symptoms of malabsorption.


CONCLUSIONS
DDSG-II is effective for treatment of T2DM obese patients, increases the enterokine FGF19, and does not cause biliary salt malabsorption.
['Foschi|Diego A|DA|', 'Rizzi|Andrea|A|', 'Tubazio|Igor|I|', 'Conti|Lorenzo|L|', 'Vago|Tarcisio|T|', 'Bevilacqua|Maurizio|M|', 'Magni|Alessandro|A|', 'Del Puppo|Marina|M|']
D000328:Adult D016022:Case-Control Studies D002783:Cholestenones D003924:Diabetes Mellitus, Type 2 D005260:Female D005346:Fibroblast Growth Factors D005743:Gastrectomy D006801:Humans D007408:Intestinal Absorption D008297:Male D008875:Middle Aged D009765:Obesity D016896:Treatment Outcome D015431:Weight Loss
Ileal interposition Malabsorption T2DM FGF19 C4