PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer.
Poly (ADP-ribose) polymerases (PARPs) are enzymes that transfer ADP-ribose groups to target proteins and are involved in a variety of biological processes. PARP6 is a novel member, and our previous findings suggest that PARP6 may act as a tumor suppressor via suppressing cell cycle progression. However, it is still unclear that PARP6 function besides growth suppression in colorectal cancer (CRC). In this study, we examined tumor suppressive roles of PAPR6 in CRC cells both in vitro and in vivo. We found that PARP6 inhibited colony formation, invasion and migration as well as cell proliferation. Moreover, ectopic overexpression of PARP6 decreased Survivin expression, which acts as an oncogene and is involved in apoptosis and mitosis. We confirmed the inverse correlation between PARP6 and Survivin expression in CRC cases by immunohistochemistry. Importantly, CRC cases with downregulation of PARP6 and upregulation of Survivin showed poor prognosis. In summary, PARP6 acts as a tumor suppressor via downregulating Survivin expression in CRC. PARP6 can be a novel diagnostic and therapeutic target together with Survivin for CRC.
['Qi|Guangying|G|', 'Kudo|Yasusei|Y|', 'Tang|Bo|B|', 'Liu|Tian|T|', 'Jin|Shengjian|S|', 'Liu|Jing|J|', 'Zuo|Xiaoxu|X|', 'Mi|Sisi|S|', 'Shao|Wenhuan|W|', 'Ma|Xiaojuan|X|', 'Tsunematsu|Takaaki|T|', 'Ishimaru|Naozumi|N|', 'Zeng|Sien|S|', 'Tatsuka|Masaaki|M|', 'Shimamoto|Fumio|F|']
D036002:ADP Ribose Transferases D049109:Cell Proliferation D015179:Colorectal Neoplasms D015536:Down-Regulation D005260:Female D016147:Genes, Tumor Suppressor D006801:Humans D051034:Inhibitor of Apoptosis Proteins D008297:Male D015398:Signal Transduction D000077022:Survivin
PARP6 tumor suppressor Survivin colorectal cancer prognosis