Antioxidation, anti-hyperglycaemia and renoprotective effects of extracellular polysaccharides from Pleurotus eryngii SI-04.
The present study was designed to investigate the anti-hyperglycaemia, hypolipidemia and renoprotective effects of two extracellular polysaccharides (EPS) from the broth of Pleurotus eryngii SI-04 (EPS1 and EPS2) in mice with streptozotocin (STZ)-induced diabetic nephropathy (DN). The results showed that both EPS1 and EPS2 exhibited potential anti-DN effects, including significantly decreasing GLU levels; suppressing ALB, BUN, CRE and UA levels; reducing serum lipid (TC, TG, VLDL-C and LDL-C) levels; improving renal antioxidant status (GSH-Px, SOD, CAT and MDA); and attenuating pathological nephropathy damage. These results demonstrated that both EPS1 and EPS2 exhibited potential antioxidant, anti-hyperglycaemic, and renoprotective effects against STZ-induced DN, indicating that P. eryngii SI-04 could be used as a functional food and natural drug. In addition, the monosaccharide compositions and bond types of these two polysaccharides were analysed.
['Zhang|Chen|C|', 'Zhang|Lan|L|', 'Liu|Hui|H|', 'Zhang|Jianjun|J|', 'Hu|Chunlong|C|', 'Jia|Le|L|']
D000818:Animals D000959:Antihypertensive Agents D000975:Antioxidants D003921:Diabetes Mellitus, Experimental D003928:Diabetic Nephropathies D006801:Humans D006943:Hyperglycemia D007668:Kidney D051379:Mice D025282:Mycelium D020076:Pleurotus D011134:Polysaccharides D013311:Streptozocin
Antioxidation Anti-hyperglycaemia Renoprotection Extracellular polysaccharides