Pre- and Postgastrostomy Evaluation of Gastroesophageal Reflux in Children Using 24-Hour pH Monitoring.
The aim of this study was to evaluate 24-hour pH monitoring results before and after gastrostomy in neurological impaired (NI) children who underwent gastrostomy or Nissen fundoplication (NF) concurrently with gastrostomy.  Between March and December 2018, NI patients who had previously received pre- and postgastrostomy (Group 1) or gastrostomy + NF (Group 2) underwent pH monitoring pre- and postoperatively.  Twenty patients [12 males (60%) and the median age of 5.6 (14 months-14.7 years) years] with NI were followed up during the study period. When pre- and postgastrostomy weight and BMI z-scores were compared, the results were significantly higher in both groups after procedure (P = .043, P = .040, respectively). The clinical results of the patients after the operation showed improvement in both groups. The pH index of Group 1 (n = 11) was 2.32 (0-3.8) before gastrostomy and 3.18 (2.1-6.9) after gastrostomy (P = .061) and in Group 2 (n = 9) it was 5.85 (4.9-15.8) and 0.61 (0.3-1.3), before and after procedure (P < .001). There was a statistically significant difference in reflux index of each group. This difference was not statistically significant between the groups (P = .072). When the total bolus exposure index was compared, it was 4.01 (2.1-5.2) before gastrostomy and 5.67 (4.6-6.3) after gastrostomy in Group 1 (P = .041). In group 2, that index was found to be 9.8 (8.3-10.2) before and 1.28 (0.5-1.4) after (P < .001). There was a statistically significant difference in index after gastrostomy in Groups 1 and 2 (P = .023).  Gastrostomy feeding is an effective and safe option to achieve enteral feeding in NI children. NF concurrent with gastrostomy should be decided according to the individual patient. Clinical trials protocol registration ID number was PRS NCT00445112.
['Demirbaş|Fatma|F|', 'Demirel|Berat Dilek|BD|', 'Çaltepe|Gönül|G|', 'Abbasguliyev|Hasan|H|', 'Bernay|Rıza Ferit|RF|', 'Kalayci|Ayhan Gazi|AG|']
D000293:Adolescent D002648:Child D002675:Child, Preschool D050782:Esophageal pH Monitoring D005260:Female D005500:Follow-Up Studies D018662:Fundoplication D005764:Gastroesophageal Reflux D005774:Gastrostomy D006801:Humans D007223:Infant D008297:Male D011446:Prospective Studies D016896:Treatment Outcome
24-hour pH monitoring gastrostomy neurological impairment childhood laparoscopic Nissen fundoplication percutaneous endoscopic gastrostomy