The Effects of Lifestyle and/or Vitamin D Supplementation Interventions on Pregnancy Outcomes: What Have We Learned from the DALI Studies?
PURPOSE OF REVIEW
The DALI (vitamin D and lifestyle intervention in the prevention of gestational diabetes mellitus (GDM)) study aimed to prevent GDM with lifestyle interventions or Vitamin D supplementation (1600 IU/day). This review summarizes the learnings from the DALI studies among pregnant women with a BMI ≥ 29 kg/m2.


RECENT FINDINGS
Women diagnosed with GDM earlier in pregnancy had a worse metabolic profile than those diagnosed later. A combined physical activity (PA) and healthy eating (HE) lifestyle intervention improved both behaviours, limited gestational weight gain (GWG) and was cost-effective. Although GDM risk was unchanged, neonatal adiposity was reduced due to less sedentary time. Neither PA nor HE alone limited GWG or GDM risk. Fasting glucose was higher with HE only intervention, and lower with Vitamin D supplementation. Our combined intervention did not prevent GDM, but was cost-effective, limited GWG and reduced neonatal adiposity.
['Harreiter|Jürgen|J|', 'Desoye|Gernot|G|', 'van Poppel|Mireille N M|MNM|', 'Kautzky-Willer|Alexandra|A|', 'Dunne|Fidelma|F|', 'Corcoy|Rosa|R|', 'Devlieger|Roland|R|', 'Simmons|David|D|', '|||', 'Adelantado|Juan M|JM|', 'Damm|Peter|P|', 'Mathiesen|Elizabeth Reinhardt|ER|', 'Jensen|Dorte Moeller|DM|', 'Anderson|Lise Lotte T|LLT|', 'Lapolla|Annunziata|A|', 'Dalfrà|Maria G|MG|', 'Bertolotto|Alessandra|A|', 'Wender-Ozegowska|Ewa|E|', 'Zawiejska|Agnieszka|A|', 'Hill|David J|DJ|', 'Snoek|Frank J|FJ|']
D016640:Diabetes, Gestational D000072001:Diet, Healthy D019587:Dietary Supplements D005060:Europe D015444:Exercise D005260:Female D000070497:Healthy Lifestyle D006801:Humans D009765:Obesity D011247:Pregnancy D011256:Pregnancy Outcome D016032:Randomized Controlled Trials as Topic D014807:Vitamin D
Vitamin D Lifestyle intervention Gestational diabetes mellitus Obesity Prevention pregnancy