Serum Lipopolysaccharide-Binding Protein is Associated with Chronic Inflammation and Metabolic Syndrome in Hemodialysis Patients.
BACKGROUND
In hemodialysis (HD) patients, impaired gut barrier and alteration in microbiota in the gut is thought to increase the risk of bacterial translocation and chronic inflammation. Lipopolysaccharide-binding protein (LBP) is an acute-phase reactant that mediates immune responses triggered by microbial products. Our aim is to investigate the relationship between circulating levels of LBP, and various metabolic and inflammatory markers in HD patients. Besides, we also aim to determine its relationship among -patients with different body mass index.


PATIENTS AND METHODS
A total of 123 HD patients were stratified into three -tertiles, according to serum LBP level. The LBP and inflammatory markers were determined using immunoassay methods. A bioimpedance spectroscopy device was used for body composition measurement.


RESULTS
The serum levels of the two proinflammatory markers, high-sensitivity C-reactive protein (hsCRP) and interleukin (IL)-6, were significantly higher in patients in the upper tertile when compared with the rest of the tertiles. In HD patients, a significant positive correlation was found between serum LBP levels and CRP, IL-6, soluble CD14 (sCD14), and fasting blood glucose levels. Patients with metabolic syndrome and pre-existing cardiovascular disease had higher LBP levels than those without metabolic syndrome. Besides, obese patients were also associated with higher serum LBP levels. Multivariate regression analyses showed that IL-6 level was the strongest correlate of LBP level, followed by hsCRP level and sCD14.


CONCLUSIONS
Our study suggested that elevated plasma LBP was associated with metabolic syndrome and obesity. In addition, increased LBP level was correlated positively to markers of inflammation, and sCD14 levels.
['Lim|Paik Seong|PS|', 'Chang|Yu-Kang|YK|', 'Wu|Tsai-Kun|TK|']
D000209:Acute-Phase Proteins D000368:Aged D015415:Biomarkers D002097:C-Reactive Protein D002318:Cardiovascular Diseases D002352:Carrier Proteins D002908:Chronic Disease D003430:Cross-Sectional Studies D005260:Female D006801:Humans D007249:Inflammation D015850:Interleukin-6 D018950:Lipopolysaccharide Receptors D008297:Male D008562:Membrane Glycoproteins D024821:Metabolic Syndrome D008875:Middle Aged D009765:Obesity D006435:Renal Dialysis
Lipopolysaccharide-binding protein Inflammation Metabolic syndrome Hemodialysis