Surgical Adjuncts to Increase the Extent of Resection: Intraoperative MRI, Fluorescence, and Raman Histology.
In low-grade glioma surgery, depicting tumor margins is challenging. 7 - Bowden 2018 - Sodium Fluorescein Facilitates Guided Sampling of Diagnostic Tumor Tissue.pdf Several tools have emerged to assist surgical decision-making. Intraoperative MRI, albeit expensive and time-consuming, can provide useful information during surgery. Fluorescence-guidance with 5-aminolevulinic acid (5-ALA) helps provide real-time information during surgery regardless of brain-shift, assists in finding anaplastic foci in low-grade tumors, and enables diagnosis of malignant tissue. Raman histology has potential for detecting viable tumor in biopsied tissue and for identifying tumor infiltration in vivo. This article analyzes and discusses these surgical adjuncts.
['Hollon|Todd|T|', 'Stummer|Walter|W|', 'Orringer|Daniel|D|', 'Suero Molina|Eric|E|']
D000622:Aminolevulinic Acid D001921:Brain D001932:Brain Neoplasms D005910:Glioma D006801:Humans D008279:Magnetic Resonance Imaging D038361:Neuronavigation
Intraoperative MRI Low-grade glioma 5-Aminolevulnic acid Fluorescence-guided resections Raman spectroscopy Stimulated Raman histology