Differential Metabolomic Signatures in Patients with Weight Regain and Sustained Weight Loss After Gastric Bypass Surgery: A Pilot Study.
BACKGROUND
While Roux-en-Y gastric bypass (RYGB) is one of the most effective and durable treatment options for obesity and its comorbidities, it is complicated by long-term weight regain in over 20% of patients.


AIMS
We sought to determine the metabolite signatures of serum samples of patients with weight regain (RYGB-WR) after RYGB and features distinguishing these patients from patients with sustained weight loss (RYGB-SWL).


METHODS
We prospectively analyzed serum samples from 21 RYGB-WR patients, 14 RYGB-SWL patients, and 11 unoperated controls. The main outcome measure was their serum metabolite profile.


RESULTS
Weight regain after RYGB was associated with a unique serum metabolomic fingerprint. Most of the statistically different metabolites were involved in amino acid metabolism, one-carbon metabolism, and related nucleotide metabolism. A principal component analysis identified groups of metabolites that correlate with weight regain. Specifically, weight regain was associated with lower serum levels of metabolites related to the serine, glycine and threonine pathway, phenylalanine metabolism, tricyclic acid cycle, alanine and glutamate metabolism, and higher levels of other amino acids.


CONCLUSIONS
Weight regain after RYGB is associated with unique serum metabolite signatures. Metabolite profiling may eventually help us to identify markers that could differentiate the patients who will regain weight versus those who will likely sustain weight loss.
['Abidi|Wasif|W|', 'Nestoridi|Eirini|E|', 'Feldman|Henry|H|', 'Stefater|Margaret|M|', 'Clish|Clary|C|', 'Thompson|Christopher C|CC|', 'Stylopoulos|Nicholas|N|0000-0002-5025-7854']
D000328:Adult D000368:Aged D005260:Female D015390:Gastric Bypass D006801:Humans D008297:Male D055432:Metabolomics D008875:Middle Aged D009765:Obesity D010865:Pilot Projects D011446:Prospective Studies D015430:Weight Gain D015431:Weight Loss
Metabolomics Weight regain Gastric bypass Obesity Bariatric surgery