Curcumin Attenuated Neurotoxicity in Sporadic Animal Model of Alzheimer's Disease.
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases leading to dementia. Despite research efforts, currently there are no effective pharmacotherapeutic options for the prevention and treatment of AD. Recently, numerous studies highlighted the beneficial effects of curcumin (CUR), a natural polyphenol, in the neuroprotection. Especially, its dual antioxidant and anti-inflammatory properties attracted the interest of researchers. In fact, besides its antioxidant and anti-inflammatory properties, this biomolecule is not degraded in the intestinal tract. Additionally, CUR is able to cross the blood-brain barrier and could therefore to be used to treat neurodegenerative pathologies associated with oxidative stress, inflammation and apoptosis. The present study aimed to assess the ability of CUR to induce neuronal protective and/or recovery effects on a rat model of neurotoxicity induced by aluminum chloride (AlCl3), which mimics the sporadic form of Alzheimer's disease. Our results showed that treatment with CUR enhances pro-oxidant levels, antioxidant enzymes activities and anti-inflammatory cytokine production and decreases apoptotic cells in AlCl3-exposed hippocampus rats. Additionally, histopathological analysis of hippocampus revealed the potential of CUR in decreasing the hallmarks in the AlCl3-induced AD. We also showed that CUR post-treatment significantly improved the behavioral, oxidative stress and inflammation in AlCl3-exposed rats. Taken together, our data presented CUR as a nutraceutical potential through its protective effects that are more interesting than recovery ones in sporadic model of AD.
['ELBini-Dhouib|Ines|I|0000-0002-2224-0211', 'Doghri|Raoudha|R|', 'Ellefi|Amenallah|A|', 'Degrach|Imen|I|', 'Srairi-Abid|Najet|N|', 'Gati|Asma|A|']
D000110:Acetylcholinesterase D000077410:Aluminum Chloride D000544:Alzheimer Disease D000818:Animals D001007:Anxiety D017209:Apoptosis D001835:Body Weight D002470:Cell Survival D060825:Cognitive Dysfunction D003474:Curcumin D016207:Cytokines D004195:Disease Models, Animal D006624:Hippocampus D007249:Inflammation D018836:Inflammation Mediators D008297:Male D009410:Nerve Degeneration D018696:Neuroprotective Agents D020258:Neurotoxicity Syndromes D009929:Organ Size D018384:Oxidative Stress D017208:Rats, Wistar
neuroprotective antioxidant anti-inflammatory aluminum