Intravenous Iron sucrose and change in hemoglobin, ferritin, and oxidative stress markers among moderately anemic pregnant women attending a secondary care level Hospital in Northern India.
Background
Intravenous iron is associated with oxidative stress, and very few studies have assessed change in oxidative stress markers post infusion.


Objectives
The study aimed to measure the change in levels of hemoglobin (Hb), serum ferritin, and select oxidative stress markers (malondialdehyde [MDA], superoxide dismutase [SOD], and ferric reducing ability of plasma [FRAP]) 4 weeks following the administration of intravenous iron sucrose (IVIS) among moderately anemic pregnant women who were attending a secondary-level health-care facility, Haryana, North India.


Methods
An observational study was conducted (May 2016 to Jan 2018) among pregnant women receiving intravenous iron sucrose i.e., IVIS (300 mg per dose) diluted in 300 mL of normal saline over 20-45 min and were followed up for a period of 4 weeks after the last dose of IVIS (end line). The study outcomes were measured in the levels of Hb, serum ferritin, MDA, SOD, and FRAP from the baseline to the end line.


Results
The mean (95% confidence interval) change in the Hb and serum ferritin level 4 weeks after the last dose of IVIS was an increase of 2.5 (2.1-3.0) g/dL (P < 0.001) and 63.0 (44.7-81.3) ng/mL (P < 0.001), respectively. There were no significant changes (baseline to end line) in mean (standard deviation [SD]) MDA level and mean (SD) FRAP level. The mean (SD) SOD level declined significantly (2.2 [0.4] U/mL to 1.6 [0.5] U/mL [P < 0.001]). No life-threatening adverse events were encountered during the study.


Conclusion
IVIS was well tolerated and effective in treating moderate anemia in pregnancy. Body iron store was replenished following IVIS administration. There was no increase in oxidative stress following IVIS therapy.
['Jacob|Olivia Marie|OM|', 'Kant|Shashi|S|', 'Haldar|Partha|P|', 'Kaur|Ravneet|R|', 'Dadhwal|Vatsla|V|', 'Prakash|Shyam|S|']
D000328:Adult D018798:Anemia, Iron-Deficiency D015415:Biomarkers D005260:Female D000077605:Ferric Oxide, Saccharated D005293:Ferritins D006454:Hemoglobins D006801:Humans D007194:India D008315:Malondialdehyde D018384:Oxidative Stress D011247:Pregnancy D011446:Prospective Studies D063127:Secondary Care D013482:Superoxide Dismutase D055815:Young Adult
intravenous iron sucrose iron sucrose oxidative stress Anemia pregnancy