Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor®.
New fluorinated 3,6-dihydropyridines were obtained by the electrophilic fluorination of 1,2-dihydropyridines with Selectfluor®. These 3-fluoro-3,6-dihydropyridines were easily converted to corresponding pyridines by the elimination of hydrogen fluoride under mild conditions. A new approach to the synthesis of methyl 2-(fluoromethyl)-5-nitro-6-arylnicotinates by the fluorination of 3-fluoro-2-methyl-5-nitro-3,6-dihydropyridines or 1,2-dihydropyridines with Selectfluor® has been developed.
['Pikun|Nadiia V|NV|0000-0002-0962-1175', 'Sobolev|Arkadij|A|0000-0002-5517-1240', 'Plotniece|Aiva|A|0000-0003-2187-5693', 'Rucins|Martins|M|', 'Vigante|Brigita|B|', 'Petrova|Marina|M|0000-0002-7532-8305', 'Muhamadejev|Ruslan|R|0000-0001-6827-7290', 'Pajuste|Karlis|K|', 'Shermolovich|Yuriy G|YG|0000-0003-2242-873X']
D004095:Dihydropyridines D005461:Fluorine D054879:Halogenation D006845:Hydrocarbons, Fluorinated
electrophilic fluorination Selectfluor® dihydropyridines fluorine-containing heterocycles homoallyl long-range coupling