Chemical Constituents from Endophytic Fungus Annulohypoxylon cf. stygium in Leaves of Anoectochilus roxburghii.
The chemical investigation on endophytic fungus Annulohypoxylon cf. stygium in leaves of Anoectochilus roxburghii (Wall.) Lindl. has been performed. Sixteen compounds were isolated and their structures were identified as (-)-notoamide A, (-)-notoamide B, (+)-versicolamide B, notoamide C, notoamide D, stephacidin A, sterigmatocystin, dihydrosterigmatocystin, secosterigmatocystin, versiconol, averufanin, kipukasin D, kipukasin E, diorcinal, palmarumycin CP2 and (-)-(3R)-mellein methyl ether, respectively, by spectroscopic analysis and comparison with literature data. All the compounds were isolated from Annulohypoxylon genus for the first time. Sterigmatocystin and palmarumycin CP2 showed selective cytotoxic activities against HepG2, HeLa, MCF-7 and HT-29.
['Gao|Shuo|S|http://orcid.org/0000-0002-7772-8935', 'Tian|Wen-Jing|WJ|', 'Liao|Zu-Jian|ZJ|', 'Wang|Guang-Hui|GH|', 'Zeng|De-Quan|DQ|', 'Liu|Xiang-Zhong|XZ|', 'Wang|Xiao-Yao|XY|', 'Zhou|Hu|H|', 'Chen|Hai-Feng|HF|', 'Lin|Ting|T|http://orcid.org/0000-0002-8950-3071']
D000972:Antineoplastic Agents, Phytogenic D001203:Ascomycota D002460:Cell Line D049109:Cell Proliferation D004354:Drug Screening Assays, Antitumor D006801:Humans D015394:Molecular Structure D009281:Naphthalenes D029595:Orchidaceae D018515:Plant Leaves D013141:Spiro Compounds D013241:Sterigmatocystin
endophytic fungus Annulohypoxylon cf. stygium cytotoxicity structure elucidation