lncRNA‑MM2P downregulates the production of pro‑inflammatory cytokines in acute gouty arthritis.
Acute gouty arthritis (AGA) is characterized by the accumulation of pro‑inflammatory cytokines, which are immunological responses to monosodium urate (MSU) crystals. It has been demonstrated that long non‑coding RNA (lncRNA)‑MM2P is a novel regulator of M2 polarization of macrophages. The aim of the present study was to investigate whether lncRNA‑MM2P regulates the MSU‑induced inflammatory process. In cell models of RAW 264.7 and THP‑1‑derived macrophages, decreased expression of lncRNA‑MM2P was observed in lipopolysaccharide‑ and MSU‑treated macrophages, which was accompanied with obvious inflammatory responses. Using small interfering RNA to knockdown lncRNA‑MM2P led to the upregulation of MSU‑mediated inflammatory responses, both in RAW 264.7 and THP‑1‑derived macrophages. In conclusion, lncRNA‑MM2P could be an important regulator of MSU‑induced inflammation, and therefore could be involved in the development of AGA.
['Zhang|Xifeng|X|', 'Zou|Ying|Y|', 'Zheng|Jiangxia|J|', 'Ji|Senguo|S|', 'Wen|Xiuzhen|X|', 'Ye|Feng|F|', 'Liu|Ju|J|', 'Li|Xueyong|X|', 'Lei|Jin|J|', 'Qiu|Mingliang|M|']
D000818:Animals D015210:Arthritis, Gouty D016207:Cytokines D015536:Down-Regulation D055785:Gene Knockdown Techniques D006801:Humans D008070:Lipopolysaccharides D051379:Mice D008954:Models, Biological D000067996:RAW 264.7 Cells D062085:RNA, Long Noncoding D000074084:THP-1 Cells D014527:Uric Acid
acute gouty arthritis regulator ong non-coding rna-MM2P monosodium  urate-induced inflammation