Dynamic contrast-enhanced MR imaging of the rectum: Correlations between single-section and whole-tumor histogram analyses.
PURPOSE
To evaluate the interobserver and intermethod correlations of histogram metrics of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters acquired by multiple readers using the single-section and whole-tumor volume methods.


MATERIALS AND METHODS
Four DCE parameters (Ktrans, Kep, Ve , Vp) were evaluated in 45 patients (31 men and 14 women; mean age, 61±11 years [range, 29-83 years]) with locally advanced rectal cancer using pre-chemoradiotherapy (CRT) MRI. Ten histogram metrics were extracted using two methods of lesion selection performed by three radiologists: the whole-tumor volume method for the whole tumor on axial section-by-section images and the single-section method for the entire area of the tumor on one axial image. The interobserver and intermethod correlations were evaluated using the intraclass correlation coefficients (ICCs).


RESULTS
The ICCs showed excellent interobserver and intermethod correlations in most of histogram metrics of the DCE parameters. The ICCs among the three readers were > 0.7 (P<0.001) for all histogram metrics, except for the minimum and maximum. The intermethod correlations for most of the histogram metrics were excellent for each radiologist, regardless of the differences in the radiologists' experience.


CONCLUSION
The interobserver and intermethod correlations for most of the histogram metrics of the DCE parameters are excellent in rectal cancer. Therefore, the single-section method may be a potential alternative to the whole-tumor volume method using pre-CRT MRI, despite the fact that the high agreement between the two methods cannot be extrapolated to post-CRT MRI.
['Choi|M H|MH|', 'Oh|S N|SN|', 'Park|G E|GE|', 'Yeo|D-M|DM|', 'Jung|S E|SE|']
D000230:Adenocarcinoma D000328:Adult D000368:Aged D000369:Aged, 80 and over D003287:Contrast Media D005260:Female D006801:Humans D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D015588:Observer Variation D012004:Rectal Neoplasms D012189:Retrospective Studies D047368:Tumor Burden
Histogram Rectal cancer Dynamic contrast-enhanced MRI Interobserver variability Quantitative measurement