Could Sirtuin Activities Modify ALS Onset and Progression?
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a complex etiology. Sirtuins have been implicated as disease-modifying factors in several neurological disorders, and in the past decade, attempts have been made to check if manipulating Sirtuin activities and levels could confer benefit in terms of neuroprotection and survival in ALS models. The efforts have largely focused on mutant SOD1, and while limited in scope, the results were largely positive. Here, the body of work linking Sirtuins with ALS is reviewed, with discussions on how Sirtuins and their activities may impact on the major etiological mechanisms of ALS. Moving forward, it is important that the potentially beneficial effect of Sirtuins in ALS disease onset and progression are assessed in ALS models with TDP-43, FUS, and C9orf72 mutations.
['Tang|Bor Luen|BL|']
D000690:Amyotrophic Lateral Sclerosis D000818:Animals D018450:Disease Progression D006801:Humans D009046:Motor Neurons D037761:Sirtuins D000072105:Superoxide Dismutase-1
Sirtuins Amyotrophic lateral sclerosis (ALS) Motor neuron Neuronal degeneration