Multi-reoperations for lung metastases.
In this study, we investigated role and results of multi-reoperations for lung metastases. From 1986 to 2010, 113 consecutive patients (61 men and 52 women; mean age: 53.2 ± 12.8 years) underwent repeated lung metastasectomy with curative intent in our institution. Two procedures were performed in 113 patients, three in 54, four in 31, five in eight and six in three. There was no perioperative mortality. Cumulative 5-year survival was 65% and this was significantly higher than the value recorded for patients undergoing only one metastasectomy (42%; p = 0.021). Size, number of resections and probability of recurrence increased by number of operation whereas disease free interval reduced. At any metastasectomy both short disease-free interval and multiple metastases resulted in the most significant negative prognosticators. In conclusion, redo metastasectomy is worthwhile for the initial procedures, afterwards both disease-free and overall survivals decrease and surgery lose its efficacy.
['Mineo|Tommaso Claudio|TC|', 'Ambrogi|Vincenzo|V|', 'Tacconi|Federico|F|', 'Mineo|Davide|D|']
D000328:Adult D000368:Aged D018572:Disease-Free Survival D005260:Female D006801:Humans D008175:Lung Neoplasms D008297:Male D059146:Metastasectomy D008875:Middle Aged D009364:Neoplasm Recurrence, Local D011013:Pneumonectomy D012086:Reoperation D012189:Retrospective Studies D015996:Survival Rate D016896:Treatment Outcome
pulmonary metastases thoracic surgery