Exosomes as a Multicomponent Biomarker Platform in Cancer.
Cancer is a complex disease that is associated with genetic aberrations and subsequent cellular and noncellular host responses. Tumors harbor diverse cell types that engage in a dynamic interplay to sustain cancer-specific signaling networks. A component of such cellular communication is the production and exchange of various types of extracellular vesicle (EV). Exosomes are small EVs with growing recognition for their role in cancer progression and resistance to therapy. The unique biogenesis of exosomes, their ubiquitous production by all cell types, and their biological features in liquid biopsies have generated excitement for their potential as cancer biomarkers. Here, we discuss the challenges and utility of exosomes as multiparameter biomarker platforms for the detection of cancer. Exosomes reflect heterogeneous biological changes associated with growing tumors, potentially offering a more comprehensive assessment of cancer diagnosis, prognosis, and progression.
['LeBleu|Valerie S|VS|', 'Kalluri|Raghu|R|']
D000970:Antineoplastic Agents D014408:Biomarkers, Tumor D001826:Body Fluids D002450:Cell Communication D018450:Disease Progression D016903:Drug Monitoring D055354:Exosomes D057166:High-Throughput Screening Assays D006801:Humans D007167:Immunotherapy D000073890:Liquid Biopsy D009369:Neoplasms D011379:Prognosis D015398:Signal Transduction D016896:Treatment Outcome D054928:Validation Studies as Topic
exosomes extracellular vesicles liquid biopsy cancer biomarker