Isolated transfusion of leucocyte-depleted apheresis platelet concentrates and outcomes after cardiac surgery.
We investigated the association of isolated leucocyte-depleted single-donor apheresis platelet concentrate transfusion with short- and long-term outcomes of patients undergoing isolated or combined coronary artery bypass and valve surgery. Propensity score matching was used to compare the results of patients without blood product transfusion and patients with isolated platelet transfusion (n = 167 per group). The primary end-point was a composite of operative complications. Additionally, we assessed coronary reintervention and overall mortality over a follow-up period of 7.5 years. In the platelet- and platelet+ groups, the composite end-point was reached at 9.6% and 12.3%, respectively (P = 0.307). None of the patients died within 30 days. None of the patients needed coronary reintervention during follow-up. Long-term mortality was similar between groups (P > 0.05). Isolated leucocyte-depleted apheresis platelet transfusion does not appear to be associated with an increase in morbidity or mortality in non-complex cardiac surgery. However, larger studies are needed.
['Koster|Andreas|A|', 'Zittermann|Armin|A|', 'Birschmann|Ingvild|I|', 'Gummert|Jan|J|']
D001781:Blood Component Removal D001792:Blood Platelets D006348:Cardiac Surgical Procedures D005260:Female D005858:Germany D006801:Humans D008297:Male D008875:Middle Aged D009017:Morbidity D017713:Platelet Transfusion D011183:Postoperative Complications D057216:Propensity Score
Coronary reintervention Mortality Transfusion-related immune modulation