Different transcriptional levels of GABAA receptor subunits in mouse cumulus cells around oocytes at different mature stage.
γ-Aminobutyric acid (GABA) is a principal inhibitory neurotransmitter in the central nervous system (CNS) of vertebrates. However, GABA and its receptor are found not only in peripheral neuronal tissue but also in many peripheral nonneuronal tissues, and thought to have multiple physiological functions. The bidirectional communication between oocytes and cumulus cells (CCs) plays a significant role in oocyte maturation and metabolism. In our previously study, the expression level of α5 subunit in CCs isolated from oocytes of patients with polycystic ovary syndrome had been found to be associated with oocyte nuclear maturity. In this study, we investigated the transcriptional levels of GABAA receptor subunits in germinal vesicle (GV) and metaphase II (MII) mouse CCs, and explored the role of GABA-A receptor subunits during ovarian follicular development and oocyte maturation. We found that GABAA receptor subunits exhibited differential transcriptional levels in CCs at different oocyte nuclear maturity stages. It suggested an involvement of GABA-A receptor subunits related to oocyte maturation and certain functions.
['Dai|Huangguan|H|', 'Hao|Cuifang|C|', 'Huang|Xin|X|', 'Liu|Zhenteng|Z|', 'Lian|Huayu|H|', 'Liu|Chang|C|']
D000818:Animals D054885:Cumulus Cells D005260:Female D051379:Mice D009865:Oocytes D009866:Oogenesis D011963:Receptors, GABA-A
mouse Cumulus cells GABA oocyte maturation GABA receptor