Serum Cystatin C can detect impaired graft function early after renal transplantation.
OBJECTIVES
To study the significance of Cystatin C (Cys C) in early detection of the graft function after renal transplantation.


MATERIAL
The concentrations of Cys C, Blood urea nitrogen (BUN), Serum creatinine (SCr), and glomerular filtration rate (GFR) were measured. According to the results of the post-transplantation GFR; Seventy renal post-transplanted patients were assigned into 3 groups: group A (31 cases with the normal range of the renal function, GFR≥90 ml/min/1.73 m(2)), group B (27 cases with Scr<133 μmol/L and 60<GFR<90 ml/min/1.73 m(2)), and group C (12 cases with Scr≥133 μmol/L and 60<Ccr<90 ml/min/1.73 m(2)). Meanwhile, 60 cases with normal renal function were applied as control group.


RESULTS
The Cys C concentration in group B (1.37±0.14) was significantly higher than it in group A (0.96±0.10) (P<0.01). The SCr and the Cys C demonstrated linear correlations with the GFR in all groups of A, B and C. The correlation coefficients (r) in each group were -0.7272 and -0.7439, -0.7072 and -0.7543, -0.7430 and -0.7669; respectively.


CONCLUSIONS
Compared with Scr, Cys C has better correlations with GFR when the graft function was normal or renal function was slightly impaired. Cys C could be used in the early detection of renal function impairment after transplantation.
['Zhou|Shi-Ming|SM|', 'Zhao|Wei|W|', 'Lin|Tao|T|', 'Zhao|Sheng-Tian|ST|', 'Wang|Hong-Wei|HW|']
Cystatin C graft renal transplantation renal function