Sigma Receptor (σR) Ligands with Antiproliferative and Anticancer Activity.
Sigma receptor (σR) ligands have proven to be useful as cancer diagnostics and anticancer therapeutics and their ligands have been developed as molecular probes in oncology. Moreover, various σR ligands generate cancer cell death in vitro and in vivo. These σR ligands have exhibited promising results against numerous human and rodent cancers and are investigated under preclinical and clinical study trials, indicating a new category of drugs in cancer therapy.
['Georgiadis|Markos-Orestis|MO|', 'Karoutzou|Olga|O|', 'Foscolos|Angeliki-Sofia|AS|', 'Papanastasiou|Ioannis|I|']
D000818:Animals D000970:Antineoplastic Agents D045744:Cell Line, Tumor D049109:Cell Proliferation D002470:Cell Survival D005456:Fluorescent Dyes D006801:Humans D008024:Ligands D015335:Molecular Probes D058990:Molecular Targeted Therapy D009369:Neoplasms D019275:Radiopharmaceuticals D017480:Receptors, sigma D012377:Rodentia
anticancer activity antiproliferative activity biomarkers radiolabeled and fluorescent probes sigma 1 receptor antagonist sigma 2 receptor agonist