Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?
Ezrin, radixin and moesin, which are strongly expressed in the Schwann cell microvilli, are putative targets for autoantibodies in acute or chronic inflammatory demyelinating polyneuropathy (AIDP or CIDP). An association between anti-moesin IgG antibodies and cytomegalovirus-related AIDP has been postulated. None of 41 AIDP patients, including 8 cytomegalovirus-related AIDP patients, and 23 CIDP had IgG or IgM antibodies to ezrin, radixin and moesin; whereas, one patient with cytomegalovirus-related AIDP had anti-ezrin IgM antibodies. Ezrin, radixin and moesin are unlikely targets for autoantibodies in AIDP and CIDP, and the association of anti-moesin antibodies with cytomegalovirus-related AIDP was not confirmed.
['Miyaji|Kazuki|K|', 'Shahrizaila|Nortina|N|', 'Umapathi|Thirugnanam|T|', 'Chan|Yee-Cheun|YC|', 'Hirata|Koichi|K|', 'Yuki|Nobuhiro|N|']
D001323:Autoantibodies D003598:Cytoskeletal Proteins D005260:Female D015870:Gene Expression D020275:Guillain-Barre Syndrome D006801:Humans D007074:Immunoglobulin G D007075:Immunoglobulin M D008297:Male D008565:Membrane Proteins D008840:Microfilament Proteins D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Ezrin Radixin Moesin Chronic inflammatory demyelinating polyneuropathies Acute inflammatory demyelinating polyneuropathies