Usefulness of the murine model to study the immune response against Histoplasma capsulatum infection.
The present paper is an overview of the primary events that are associated with the histoplasmosis immune response in the murine model. Valuable data that have been recorded in the scientific literature have contributed to an improved understanding of the clinical course of this systemic mycosis, which is caused by the dimorphic fungus Histoplasma capsulatum. Data must be analyzed carefully, given that misinterpretation could be generated because most of the available information is based on experimental host-parasite interactions that used inappropriate proceedings, i.e., the non-natural route of infection with the parasitic and virulent fungal yeast-phase, which is not the usual infective phase of the etiological agent of this mycosis. Thus, due to their versatility, complexity, and similarities with humans, several murine models have played a fundamental role in exploring the host-parasite interaction during H. capsulatum infection.
['Sahaza|Jorge H|JH|', 'Pérez-Torres|Armando|A|', 'Zenteno|Edgar|E|', 'Taylor|Maria Lucia|ML|']
D056704:Adaptive Immunity D056809:Alveolar Epithelial Cells D000818:Animals D016175:B-Lymphocyte Subsets D002473:Cell Wall D003713:Dendritic Cells D004195:Disease Models, Animal D006658:Histoplasma D006660:Histoplasmosis D058507:Host Specificity D006801:Humans D007113:Immunity, Innate D051379:Mice D013045:Species Specificity D016176:T-Lymphocyte Subsets
Murine model Histoplasma capsulatum Histoplasmosis Adaptive response. Innate immunity