Translational Control of the HIV Unspliced Genomic RNA.
Post-transcriptional control in both HIV-1 and HIV-2 is a highly regulated process that commences in the nucleus of the host infected cell and finishes by the expression of viral proteins in the cytoplasm. Expression of the unspliced genomic RNA is particularly controlled at the level of RNA splicing, export, and translation. It appears increasingly obvious that all these steps are interconnected and they result in the building of a viral ribonucleoprotein complex (RNP) that must be efficiently translated in the cytosolic compartment. This review summarizes our knowledge about the genesis, localization, and expression of this viral RNP.
['Rojas-Araya|Bárbara|B|', 'Ohlmann|Théophile|T|', 'Soto-Rifo|Ricardo|R|']
D002467:Cell Nucleus D003593:Cytoplasm D015967:Gene Expression Regulation, Viral D015497:HIV-1 D015498:HIV-2 D054884:Host-Pathogen Interactions D006801:Humans D014176:Protein Biosynthesis D012367:RNA, Viral D012261:Ribonucleoproteins D014764:Viral Proteins D014779:Virus Replication
HIV-1 DDX3 IRES Rev cap-dependent translation nuclear export