Involvement of T lymphocytes in the placentae with villitis of unknown etiology from pregnancies complicated with preeclampsia.
OBJECTIVE
The aim of the study was to compare immunohistochemical expression of different T type lymphocytes in foci of villitis of placentae with villitis of unknown etiology (VUE) without and with preeclampsia (PE).


METHODS
Fifty-four placentae were collected from women who had VUE with (N = 27) and without (N = 27) PE. Immunohistochemistry for types of T lymphocytes was performed on formalin fixed and paraffin-embedded sections by use of the CD3, CD4, FOXP3, CD25, CD8 and CD68 antibodies. All data analyses were done by R Development Core Team.


RESULTS
There was higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE compared to control group.


CONCLUSION
The higher immunohistochemical CD4 positive T lymphocyte count and CD4 positive/CD8 positive ratio in placentae with VUE complicated with PE could point to their role in ethiopathogenesis of PE.
['Benzon|Sandra|S|', 'Zekić Tomaš|Sandra|S|', 'Benzon|Zdeslav|Z|', 'Vulić|Marko|M|', 'Kuzmić Prusac|Ivana|I|']
D000328:Adult D015496:CD4-Positive T-Lymphocytes D016022:Case-Control Studies D002824:Chorionic Villi D005260:Female D006801:Humans D007249:Inflammation D010920:Placenta D010922:Placenta Diseases D011225:Pre-Eclampsia D011247:Pregnancy
T lymphocytes villitis of unknown etiology Preeclampsia