Online HIV prevention intervention on condomless sex among men who have sex with men: a web-based randomized controlled trial.
BACKGROUND
Given the widespread use of the Internet among men who have sex with men (MSM) and high risk of Internet-facilitated sexual behaviors, Internet-based interventions to reduce sexual risk are urgently needed.


METHODS
We recruited 1,100 participants from online and randomly assigned to two groups. One group received online HIV intervention services. Online HIV intervention was developed through mix-method formative research, measures included scenarios experiencing intervention and HIV information dissemination. Self-reported condomless anal sex with a male in the past three months was measured to evaluate the intervention effect.


RESULT
Of the 1,100 participants, the majority were aged between 21 and 30 years old (62%), had a college degree or higher (80%), were single (88%), and self-identified as homosexual (78%). The estimated risk difference of condomless sex with a male in the past three months between groups was 9.3% (95% confidence interval (CI): 1.1, 17.5%). Using multiple imputations intention-to-treat, the estimated risk difference was 8.9% (95%CI: 1.2, 16.6%). Modification effects were found between intervention and characteristics including: educational attainment (p = 0.012), marital status (p = 0.005) and awareness of AIDS-related knowledge (p = 0.010).


CONCLUSION
Internet appears to be a promising approach to disseminate HIV prevention amongst MSM. Interactive online intervention appeals to MSM and poses a great potential for reducing HIV risky behavior.


TRIAL REGISTRATION
ChiCTR1800014260 (retrospectively registered 2 Jan, 2018).
['Cheng|Weibin|W|http://orcid.org/0000-0002-9845-6676', 'Xu|Huifang|H|', 'Tang|Weiming|W|', 'Zhong|Fei|F|', 'Meng|Gang|G|', 'Han|Zhigang|Z|', 'Zhao|Jinkou|J|']
D000163:Acquired Immunodeficiency Syndrome D000328:Adult D015658:HIV Infections D018451:Homosexuality, Male D006801:Humans D020407:Internet D008297:Male D017533:Marital Status D008875:Middle Aged D012309:Risk-Taking D012725:Sexual Behavior D047568:Unsafe Sex
Intervention Condomless sex Men who have sex with men Randomized controlled trial Internet Human immunodeficiency virus