Controlled release of 5-fluorouracil from microporous zeolites.
UNLABELLED
Zeolite particles with different pore diameter and particle size were loaded with the model anticancer drug 5-fluorouracil. The loaded zeolites were characterized by means of SEM, XRD, DSC, XPS, N2 physisorption and FT-IR. Higher loading of 5-FU was observed for NaX-FAU than BEA. Release studies were carried out in HCl 0.1N. Release of 5-FU from NaX-FAU showed exponential-type behaviour with the drug fully released within 10 min. In the case of BEA, the kinetics of 5-FU shows a multi-step profile with prolonged release over time. Molecular dynamics simulations showed that diffusion of the drug molecule through the BEA framework is lower than for NaX-FAU due to increased van der Waals interaction between the drug and the framework. The effect of zeolitic particles on the viability of Caco-2 monolayers showed that the NaX-FAU particles cause a reduction of cell viability in a more pronounced way compared with the BEA particles.


FROM THE CLINICAL EDITOR
This article describes zeolite-based nanoparticles in generating time-controlled release of 5-FU from zeolite preparations for anti-cancer therapy.
['Spanakis|Marios|M|', 'Bouropoulos|Nikolaos|N|', 'Theodoropoulos|Dimitrios|D|', 'Sygellou|Lamprini|L|', 'Ewart|Sinead|S|', 'Moschovi|Anastasia Maria|AM|', 'Siokou|Angeliki|A|', 'Niopas|Ioannis|I|', 'Kachrimanis|Kyriakos|K|', 'Nikolakis|Vladimiros|V|', 'Cox|Paul A|PA|', 'Vizirianakis|Ioannis S|IS|', 'Fatouros|Dimitrios G|DG|']
D000970:Antineoplastic Agents D018938:Caco-2 Cells D002470:Cell Survival D004058:Diffusion D004337:Drug Carriers D005472:Fluorouracil D006801:Humans D007700:Kinetics D056004:Molecular Dynamics Simulation D053758:Nanoparticles D009369:Neoplasms D017550:Spectroscopy, Fourier Transform Infrared D017641:Zeolites
Controlled release Zeolites Cytocompatibility Molecular modeling