Sleep Duration and Neurocognitive Function in the Hispanic Community Health Study/Study of Latinos.
STUDY OBJECTIVES
To evaluate the association between sleep duration and neurocognitive function in a representative sample of middle-aged to older Hispanic/Latino adults in the US. We tested the hypothesis that sleep duration has a nonlinear, inverted U-shaped association with neurocognitive function.


METHODS
We performed a cross-sectional analysis from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) participants ages 45-74 years (n = 8,676). HCHS/SOL is a community-based cohort from four US urban areas sampled using a probability design from 2008-2011. Self-reported sleep duration was calculated as a weighted average of the difference between habitual wake and bedtimes assessed by separate questions for weekdays and weekends. Neurocognitive function was measured with standardized scores for Word (Phonemic) Fluency (WF), Brief-Spanish English Verbal learning test (B-SEVLT), and Digit Symbol Substitution (DSS) tests.


RESULTS
The mean age was 56.5 years; 55% were women; and 40.4% had less than high school education. Average sleep duration was 7.8 ± 1.7 hours. There was an inverted U-shaped association with sleep duration and WF, B-SEVLT sum, and the DSS, with no association with B-SEVLT delayed-recall. Participants with intermediate sleep duration had the best neurocognitive function, while long sleepers had worse neurocognitive function adjusting for demographic, behavioral, and medical factors, daytime sleepiness, and use of sleep medications.


CONCLUSIONS
Sleep duration had curvilinear inverted U-shaped associations with neurocognitive function, with worse scores among participants with longer sleep duration. These findings may provide a framework to further examine sleep duration in the prevention and treatment of neurocognitive disorders.
['Ramos|Alberto R|AR|', 'Tarraf|Wassim|W|', 'Daviglus|Martha|M|', 'Davis|Sonia|S|', 'Gallo|Linda C|LC|', 'Mossavar-Rahmani|Yasmin|Y|', 'Penedo|Frank J|FJ|', 'Redline|Susan|S|', 'Rundek|Tatjana|T|', 'Sacco|Ralph L|RL|', 'Sotres-Alvarez|Daniela|D|', 'Wright|Clinton B|CB|', 'Zee|Phyllis C|PC|', 'González|Hector M|HM|']
D000368:Aged D003071:Cognition D015331:Cohort Studies D003153:Community Health Services D003430:Cross-Sectional Studies D005260:Female D006630:Hispanic or Latino D006801:Humans D008297:Male D008875:Middle Aged D009483:Neuropsychological Tests D011446:Prospective Studies D012111:Residence Characteristics D057566:Self Report D012890:Sleep D013997:Time Factors D014481:United States
sleep neurocognitive Hispanic/Latino epidemiology