Diagnostic and Prognostic Roles of Serum Interleukin-6 Levels in Patients with Uveitis.
PURPOSE
To examine the diagnostic and prognostic roles of serum interleukin-6 levels in patients with uveitis.


METHODS
This was a retrospective observational case series. Demographic and clinical characteristics were compared between Group One (sixty patients) with normal serum IL-6 levels and Group Two (twenty patients) with high serum interleukin-6 levels.


RESULTS
Mean IL-6 level was 1.77 ± 0.97 pg/ml and 10.2 ± 9.7 pg/ml in Group One and Group Two respectively. Age, presence of systemic disease, and mean number of flare-ups were statistically significant (p = .015, p = .000, p = .03, respectively). Multivariate analysis was performed on variables that were statistically significant in univariate analysis and showed that three variables had significant correlation with IL-6 levels in both groups: systemic disease (OR = 10.83, p < .001), Age (OR = 0.95, p = .03) and number of flare-ups (OR = 2.9, p = .02).


CONCLUSION
Serum IL-6 levels can provide diagnostic and prognostic information in regard to the course of disease and its treatment.
['Maleki|Arash|A|', 'Gomez|Sebastian|S|', 'Asgari|Soheila|S|', 'Bosenberg|Zoe|Z|', 'Manhapra|Ambika|A|', 'Walsh|Marisa|M|', 'Weng|Angelina|A|', 'Tseng|Catherine|C|', 'He|Celestine|C|', 'Anesi|Stephen Damien|SD|', 'Foster|C Stephen|CS|']
interleukin-6 uveitis Behçet’s disease juvenile idiopathic arthritis rheumatoid arthritis systemic lupus erythematosus