Ninety-day toxicity and single-dose toxicokinetics study of alpha-glycosyl isoquercitrin in Sprague-Dawley rats.
alpha-Glycosyl isoquercitrin (AGIQ) is highly absorbable and has been shown to possess antioxidative properties. Based on a favorable safety profile, it has been confirmed as generally recognized as safe (GRAS) compound by the FDA. Nevertheless, safety and toxicity information for AGIQ is still sparse. Therefore, the aim of this study was to test the safety and toxicokinetics of AGIQ in a 90-day study in 60 male and 60 female Sprague-Dawley rats at dietary doses up to 5%. All animals survived until scheduled euthanasia with no clinical signs of toxicity in any animal. AGIQ was rapidly absorbed with metabolism to quercetin and quercetin glucuronide at all dose levels. Statistically significant changes were noted in some tissue weights and clinical chemistry analytes, without evidence of systemic toxicity. The most prominent finding was systemic dose dependent yellow discoloration of bones of treated animals. However, no changes were observed microscopically, and this observation was concluded as toxicologically insignificant. The overall lack of adverse clinical signs, changes in body weight, feed consumption, clinical pathology parameters, and histopathological endpoints in animals administered AGIQ supports no observable adverse effect levels (NOAEL) of 5.0% in diet for both male and female rats (3461 mg/kg/day and 3867 mg/kg/day, respectively).
['Nyska|Abraham|A|', 'Hayashi|Shim-Mo|SM|', 'Koyanagi|Mihoko|M|', 'Davis|Jeffrey P|JP|', 'Jokinen|Micheal P|MP|', 'Ramot|Yuval|Y|', 'Maronpot|Robert R|RR|']
D000284:Administration, Oral D000818:Animals D001835:Body Weight D004305:Dose-Response Relationship, Drug D005260:Female D006027:Glycosides D006403:Hematologic Tests D008297:Male D009043:Motor Activity D009929:Organ Size D011794:Quercetin D051381:Rats D017207:Rats, Sprague-Dawley D066007:Toxicokinetics
Toxicity Toxicokinetics Alpha-glycosyl isoquercitrin Isoquercitrin Sprague-Dawley AGIQ Safety Quercetin EMIQ Flavonol