Magnetic hyperthermia efficiency in the cellular environment for different nanoparticle designs.
Magnetic hyperthermia mediated by magnetic nanomaterials is one promising antitumoral nanotherapy, particularly for its ability to remotely destroy deep tumors. More and more new nanomaterials are being developed for this purpose, with improved heat-generating properties in solution. However, although the ultimate target of these treatments is the tumor cell, the heating efficiency, and the underlying mechanisms, are rarely studied in the cellular environment. Here we attempt to fill this gap by making systematic measurements of both hyperthermia and magnetism in controlled cell environments, using a wide range of nanomaterials. In particular, we report a systematic fall in the heating efficiency for nanomaterials associated with tumour cells. Real-time measurements showed that this loss of heat-generating power occurred very rapidly, within a matter of minutes. The fall in heating correlated with the magnetic characterization of the samples, demonstrating a complete inhibition of the Brownian relaxation in cellular conditions.
['Di Corato|Riccardo|R|', 'Espinosa|Ana|A|', 'Lartigue|Lenaic|L|', 'Tharaud|Mickael|M|', 'Chat|Sophie|S|', 'Pellegrino|Teresa|T|', 'Ménager|Christine|C|', 'Gazeau|Florence|F|', 'Wilhelm|Claire|C|']
D016880:Anisotropy D045744:Cell Line, Tumor D002470:Cell Survival D060833:Cellular Microenvironment D006358:Hot Temperature D006801:Humans D006979:Hyperthermia, Induced D060328:Magnetic Phenomena D053758:Nanoparticles D036103:Nanotechnology D012996:Solutions D013054:Spectrophotometry, Atomic
Magnetic hyperthermia Nanoparticles Cell interactions Nanomagnetism Nanomedicine