The usefulness of serial pancreatic juice aspiration cytological examination for pancreatic cancer not diagnosed by EUS-FNAB.
Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) is safe and useful for the diagnosis of pancreatic cancer. However, sometimes a diagnosis cannot be established by EUS-FNAB. The efficacy of serial pancreatic juice aspiration cytological examination (SPACE) for pancreatic cancer was reported. SPACE may be useful in cases in which diagnosis by EUS-FNAB is difficult; however, this has not been reported previously. We herein report two cases of pancreatic cancer diagnosed by SPACE when diagnosis by EUS-FNAB was difficult. Case 1 was a 77-year-old female. She was suspected of pancreatic cancer because of new-onset diabetes. We performed EUS-FNAB to the lesion in the pancreatic body; however, diagnosis failed. We performed SPACE and diagnosed pancreatic cancer finally. Case 2 was 72 years old female. She was suspected of having pancreatic cancer because of the dilatation of the pancreatic duct. We performed EUS-FNAB twice to the lesion in the pancreatic head, however, diagnosis failed. Therefore, we performed SPACE and got final diagnosis as pancreatic cancer. From our experience, we suggest that SPACE is a useful diagnostic method for patients with pancreatic cancer that are difficult to diagnose.
['Ishikawa-Kakiya|Yuki|Y|', 'Maruyama|Hirotsugu|H|http://orcid.org/0000-0002-8728-8101', 'Kinoshita|Yosuke|Y|', 'Hayashi|Kappei|K|', 'Yamamura|Masafumi|M|', 'Tanoue|Kojiro|K|', 'Nagami|Yasuaki|Y|', 'Tanigawa|Tetsuya|T|', 'Watanabe|Toshio|T|', 'Fujiwara|Yasuhiro|Y|']
D000368:Aged D061765:Endoscopic Ultrasound-Guided Fine Needle Aspiration D005260:Female D006801:Humans D010179:Pancreas D010189:Pancreatic Juice D010190:Pancreatic Neoplasms
Serial pancreatic juice aspiration cytological examination Pancreatic cancer Endoscopic retrograde cholangiopancreatography Endoscopic ultrasound-guided fine needle aspiration