Identification of Signatures of Selection by Whole-Genome Resequencing of a Chinese Native Pig.
Identification of genomic signatures of selection that help reveal genetic mechanisms underlying traits in domesticated pigs is of importance. Anqing six-end-white pig (ASP), a representative of the native breeds in China, has many distinguishing phenotypic characteristics. To identify the genomic signatures of selection of the ASP, whole-genome sequencing of 20 ASPs produced 469.01 Gb of sequence data and more than 26 million single-nucleotide polymorphisms. Combining these data with the available whole genomes of 13 Chinese wild boars, 157 selected regions harboring 48 protein-coding genes were identified by applying the polymorphism levels (θπ) and genetic differentiation (F  ) based cross approaches. The genes found to be positively selected in ASP are involved in crucial biological processes such as coat color (  ), salivary secretion (  ), reproduction (  ,  ,  ,  , and  ), olfactory transduction (  ), and growth (  ,  , and  ). Our research increased the knowledge of ASP phenotype-related genes and help to improve our understanding of the underlying biological mechanisms and provide valuable genetic resources that enable effective use of pigs in agricultural production.
['Zhang|Wei|W|', 'Yang|Min|M|', 'Zhou|Mei|M|', 'Wang|Yuanlang|Y|', 'Wu|Xudong|X|', 'Zhang|Xiaodong|X|', 'Ding|Yueyun|Y|', 'Zhao|Guiying|G|', 'Yin|Zongjun|Z|', 'Wang|Chonglong|C|']
signatures of selection Anqing six-end-white pig θπ FST SNP