Limonoids from the Seeds of Swietenia macrophylla and Their Anti-Inflammatory Activities.
A new limonoid, swietemacrophin (1), was isolated from the seeds of Swietenia macrophylla, together with five known compounds 2-6. The structure of 1 was determined through extensive 1D/2D-NMR and mass-spectrometric analyses. Swietemacrophin (1), humilinolide F (2), 3,6-O,O-diacetylswietenolide (3), 3-O-tigloylswietenolide (4), and swietemahonin E (5) exhibited inhibition (IC50 values≤45.44 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP). Compounds 1, 4, 5, and swietenine (6) showed potent inhibition with IC50 values≤36.32 μM, against lipopolysaccharide (LPS)-induced nitric oxide (NO) generation.
['Chen|Li-Chai|LC|', 'Liao|Hsiang-Ruei|HR|', 'Chen|Pei-Yu|PY|', 'Kuo|Wen-Lung|WL|', 'Chang|Tsung-Hsien|TH|', 'Sung|Ping-Jyun|PJ|', 'Wen|Zhi-Hong|ZH|', 'Chen|Jih-Jung|JJ|']
D000893:Anti-Inflammatory Agents D006801:Humans D020128:Inhibitory Concentration 50 D036701:Limonins D008070:Lipopolysaccharides D029582:Meliaceae D009240:N-Formylmethionine Leucyl-Phenylalanine D009504:Neutrophils D009569:Nitric Oxide D010936:Plant Extracts D061251:Primary Cell Culture D012639:Seeds D013329:Structure-Activity Relationship D013481:Superoxides D014315:Triterpenes
limonoid Swietenia macrophylla anti-inflammatory activity Meliaceae structure elucidation