Photobiomodulation with 808-nm diode laser enhances gingival wound healing by promoting migration of human gingival mesenchymal stem cells via ROS/JNK/NF-κB/MMP-1 pathway.
Photobiomodulation (PBM) has been shown to improve wound healing by promoting mesenchymal stem cell migration and proliferation. However, it remains unknown whether an 808-nm diode laser can influence human gingival mesenchymal stem cells (HGMSCs), and which dose this works well. In the present study, it was found that PBM could promote the migration of HGMSCs but not the proliferation. Furthermore, PBM could activate mitochondrial ROS, which could elevate the phosphorylation levels of JNK and IKB in HGMSCs, and further activate NF-κB as the nuclear translocation of p65 is elevated. Taken together, these present results indicate that PBM might promote cell migration via the ROS/JNK/NF-κB pathway.
['Feng|Jie|J|', 'Li|Xiaoyan|X|', 'Zhu|Siying|S|', 'Xie|Yongmei|Y|', 'Du|Juan|J|', 'Ge|Huabing|H|', 'Bai|Yuxing|Y|', 'Liu|Yi|Y|', 'Guo|Lijia|L|http://orcid.org/0000-0001-7537-2640']
D002465:Cell Movement D005881:Gingiva D006801:Humans D048031:JNK Mitogen-Activated Protein Kinases D054023:Lasers, Semiconductor D020935:MAP Kinase Signaling System D020781:Matrix Metalloproteinase 1 D059630:Mesenchymal Stem Cells D008928:Mitochondria D016328:NF-kappa B D010766:Phosphorylation D017382:Reactive Oxygen Species D014945:Wound Healing
Migration ROS JNK NF-κB PBM Mitochondria