Prevalence of exocrine pancreatic insufficiency in type 2 diabetes mellitus with poor glycemic control.
OBJECTIVES
To evaluate the relationship between exocrine pancreatic insufficiency and the level of glycemic control in diabetes (DM).


METHODS
Patients with type 2 DM treated in our clinic were prospectively recruited into the study. Pancreatic diabetes was excluded. Cases with HbA1c ≥7% formed Group A (n = 59), and with HbA1c <7% Group B (n = 42). The fecal level of pancreatic elastase (PE-1) was measured and morphological examinations of the pancreas were performed.


RESULTS
The PE-1 level was significantly lower in Group A than in Group B (385.9 ± 171.1 μg/g, vs. 454.6 ± 147.3 μg/g, p = 0.038). The PE-1 level was not correlated with HbA1c (r = -0.132, p = 0.187), the duration of DM (r = -0.046, p = 0.65), age (r = 0.010, p = 0.921), BMI (r = 0.203, p = 0.059), or pancreatic steatosis (r = 0.117, p = 0.244). The size of the pancreas did not differ significantly between Groups A and B.


CONCLUSIONS
An exocrine pancreatic insufficiency demonstrated by fecal PE-1 determination is more frequent in type 2 DM patients with poor glycemic control. The impaired exocrine pancreatic function cannot be explained by an alteration in the size of the pancreas or by pancreatic steatosis.
['Terzin|Viktória|V|', 'Várkonyi|Tamás|T|', 'Szabolcs|Annamária|A|', 'Lengyel|Csaba|C|', 'Takács|Tamás|T|', 'Zsóri|Gábor|G|', 'Stájer|Anette|A|', 'Palkó|András|A|', 'Wittmann|Tibor|T|', 'Pálinkás|Attila|A|', 'Czakó|László|L|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D015415:Biomarkers D001786:Blood Glucose D002352:Carrier Proteins D003924:Diabetes Mellitus, Type 2 D010188:Exocrine Pancreatic Insufficiency D005260:Female D005500:Follow-Up Studies D006442:Glycated Hemoglobin A D006801:Humans D008297:Male D008875:Middle Aged D010179:Pancreas D010196:Pancreatic Elastase D015995:Prevalence D011446:Prospective Studies
Exocrine pancreatic insufficiency Diabetes mellitus Glycemic control Chronic pancreatitis Fecal elastase 1 Pancreatic enzyme replacement