Relationship between oxidative stress parameters and asymptomatic organ damage in hypertensive patients without diabetes mellitus.
OBJECTIVE
We aimed to evaluate the levels of oxidative stress (OS) parameters such as total antioxidant status or TAS, total oxidant status (TOS), OS index (OSI), paraoxonase 1 (PON1), arylesterase, and total thiol in hypertensive patients with and without asymptomatic organ damage (AOD), and to determine the relationship between these parameters and AOD.


DESIGN
Sixty-six patients (21 men, 45 women) with AOD and 66 patients without AOD (21 men, 45 women) were enrolled in the study. Serum OS parameters were measured by colorimetric method.


RESULTS
The OSI levels were found to be higher while PON1, PON1/high-density lipoprotein, and arylesterase levels were found to be lower in patients with AOD compared with those in the patients without AOD. Stepwise regression analysis showed high 24-h mean systolic blood pressure, OSI, and low arylesterase level to be independent predictors of AOD.


CONCLUSION
OS level was found to be higher in hypertensive patients with AOD compared with the patients without AOD. However, it is not clear whether increased OS leads to AOD or AOD increases the level of OS. For this purpose, OS level needs to be decreased by antioxidant therapies and patients need to be followed up for a longer duration.
['Ates|Ihsan|I|', 'Ozkayar|Nihal|N|', 'Topcuoglu|Canan|C|', 'Dede|Fatih|F|']
D000328:Adult D000368:Aged D000975:Antioxidants D043303:Aryldialkylphosphatase D002265:Carboxylic Ester Hydrolases D002339:Carotid Arteries D059168:Carotid Intima-Media Thickness D003430:Cross-Sectional Studies D005260:Female D006352:Heart Ventricles D006801:Humans D006973:Hypertension D008297:Male D008875:Middle Aged D018384:Oxidative Stress D013438:Sulfhydryl Compounds
asymptomatic organ damage hypertension total antioxidant status total oxidant status oxidative stres