Delayed administration IL-1β neutralizing antibody improves cognitive function after transient global ischemia in rats.
In order to study the protective effects on motor and cognitive function by inhibiting IL-1β as delayed as 24h after global ischemia, we designed behavioral testing protocol and histology detection after 10 min transient global ischemia followed by IL-1β or its antibody intracerebroventricular injection. We found benefit of IL-1β antibody treatment 24h after ischemia in cognitive function recovery. But no obvious amelioration in motor function was found. Further we detected cell morphology and survival by histology staining and proved IL-1β antibody could reduce ischemia induced cell morphological changes and cell loss in hippocampus, which related with cognitive function. Present results indicate intervening IL-1β pathway could be helpful in cognitive function recovery even as late as 24h after ischemia happens.
['Zhao|Bei|B|', 'Zou|Chang-Jiang|CJ|', 'Zhou|Ping|P|']
D000818:Animals D000906:Antibodies D001253:Astrocytes D001921:Brain D003072:Cognition Disorders D057967:Infusions, Intraventricular D053583:Interleukin-1beta D002546:Ischemic Attack, Transient D008297:Male D017628:Microglia D009043:Motor Activity D009474:Neurons D051381:Rats D017207:Rats, Sprague-Dawley
Delayed administration IL-1β Cognitive function Ischemia Motor function