Nonsurgical management of human immunodeficiency virus-associated parotid cysts: A systematic review and meta-analysis.
BACKGROUND
The purpose of this clinical review was to analyze the effectiveness of nonsurgical management options for human immunodeficiency virus (HIV)-associated parotid cysts.


METHODS
We conducted systematic and meta-analysis reviews. Primary outcomes were complete or partial responses.


RESULTS
Systematic review identified 12 relevant studies. The average rates of complete response for antiretroviral therapy (ART), sclerotherapy, and fine-needle aspiration (FNA) were 52.8%, 55.5%, and 33.3%, respectively. Three radiotherapy studies, totaling 104 patients, were included in a meta-analysis. Patients receiving high-dose therapy achieved complete and partial response rates of 65.8% (95% confidence interval [CI] 54.3%-76.2%) and 25.2% (95% CI 16.1%-36.3%), respectively. Patients receiving low-dose therapy achieved complete and partial response rates of 23.2% (95% CI 1.2%-60.9%) and 22.3% (95% CI 5.2%-87.8%), respectively. The rate of complete response was significantly greater for high-dose radiotherapy compared to low-dose (P < .001).


CONCLUSION
Among nonsurgical treatment modalities for HIV-associated parotid cysts, radiotherapy has the highest number of reported outcomes in the literature and our analysis suggests that higher dose radiotherapy has higher rates of achieving complete response.
['Naik|Akash N|AN|0000-0003-3592-1347', 'Clinkscales|William B|WB|', 'Kato|Masanari G|MG|', 'Nguyen|Shaun A|SA|', 'Gillespie|M Boyd|MB|']
D003560:Cysts D015658:HIV Infections D006801:Humans D010305:Parotid Diseases
human immunodeficiency virus (HIV)-associated parotid cyst antiretroviral sclerotherapy radiotherapy benign lymphoepithelial lesion