18F-fallypride PET-CT of dopamine D2/D3 receptors in patients with sporadic amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is a progressive and fatal neurodegenerative disease with unclear pathogenesis. To date, there have been no reports regarding the distribution of dopamine receptors outside the striatum in ALS patients. In this study, 17 ALS patients and 11 healthy controls underwent 18F-fallypride positron emission tomography/computed tomography (PET/CT) and completed cognitive-related tests for assessment of the distribution of dopamine receptors inside and outside the striatum in ALS and evaluation of the relationships between the distribution of dopamine receptors and cognitive function. The results showed that ALS patients showed significantly lower scores only in language and delayed recall of Montreal Cognitive Assessment scale. There were no significant differences between the two groups in the cognitive-related test results. Statistical parametric mapping (SPM) data showed that the binding affinity of 18F-fallypride in ALS patients was decreased in the bilateral nucleus accumbens septi, bilateral frontal lobes, and the superior frontal gyrus, left temporal lobe, and angular gyrus regions. In conclusion, the levels of dopamine receptors were significantly decreased in some areas outside the striatum in patients with ALS, which may contribute to mild cognitive impairment in ALS patients.
['Fu|Xiaoling|X|', 'Zhu|Wenjia|W|', 'Guo|Zhe|Z|', 'Shu|Gangming|G|', 'Cui|Fang|F|', 'Yang|Fei|F|', 'Zhang|Ying|Y|', 'Ren|Yuting|Y|', 'Zhang|Xiaojun|X|', 'Zhang|Xiaolan|X|', 'Chen|Zhaohui|Z|', 'Ling|Li|L|', 'Huang|Xusheng|X|', 'Zhang|Jinming|J|']
D000328:Adult D000368:Aged D000690:Amyotrophic Lateral Sclerosis D001549:Benzamides D000072226:Computed Tomography Angiography D065127:Dopamine D2 Receptor Antagonists D005260:Female D019788:Fluorodeoxyglucose F18 D006801:Humans D008297:Male D008875:Middle Aged D009483:Neuropsychological Tests D049268:Positron-Emission Tomography D011485:Protein Binding D017448:Receptors, Dopamine D2 D050637:Receptors, Dopamine D3
Amyotrophic lateral sclerosis Dopamine receptor Cognition (18)F-fallypride