Pantocin A, a peptide-derived antibiotic involved in biological control by plant-associated Pantoea species.
The genus Pantoea contains a broad range of plant-associated bacteria, including some economically important plant pathogens as well as some beneficial members effective as biological control agents of plant pathogens. The most well-characterized representatives of biological control agents from this genus generally produce one or more antimicrobial compounds adding to biocontrol efficacy. Some Pantoea species evaluated as biocontrol agents for fire blight disease of apple and pear produce a histidine-reversible antibiotic. Three commonly studied histidine-reversible antibiotics produced by Pantoea spp. are herbicolin O, MccEh252, and pantocin A. Pantocin A is a novel ribosomally encoded and post-translationally modified peptide natural product. Here, we review the current knowledge on the chemistry, genetics, biosynthesis, and incidence and environmental relevance of pantocin A and related histidine-reversible antibiotics produced by Pantoea.
['Smits|Theo H M|THM|http://orcid.org/0000-0002-1237-235X', 'Duffy|Brion|B|', 'Blom|Jochen|J|', 'Ishimaru|Carol A|CA|', 'Stockwell|Virginia O|VO|']
D061046:Biological Control Agents D006020:Glycopeptides D020636:Pantoea D010455:Peptides D010935:Plant Diseases
Biocontrol Fire blight Histidine-reversible Herbicolin O MccEh252 Erwinia amylovora Pantoea agglomerans Pantoea vagans