A study of in vitro antibacterial activity of lanthanides complexes with a tetradentate Schiff base ligand.
OBJECTIVE
To establish the antibacterial activity of lanthanides complexes with a tetradentate Schiff base ligand L.


METHODS
(N, N'-bis (1-naphthaldimine)-o-phenylenediamine) was prepared from the condensation of 2-hydroxy-1-naphthaldehyde with o-phenylenediamine in a molar ratio of 2:1. The antimicrobial activity of the resultant Ln (III) complexes was investigated using agar well diffusion and micro-broth dilution techniques; the latter was used to establish the minimum inhibitory concentrations for each compound investigated.


RESULTS
Most of Ln (III) complexes were found to exhibit antibacterial activities against a number of pathogenic bacteria with MICs ranging between 1.95-250.00 µg/mL. Staphylococcus aureus was the most susceptible bacterial species to [LaL(NO3)2(H2O)](NO3) complex while Shigella dysenteriae and Escherichia coli required a relatively higher MIC (250 µg/mL). The complexes La (III) and Pr (III) were effective inhibitors against Staphylococcus aureus, whereas Sm (III) complex was effective against Serratia marcescens. On the other hand, Gd (III), La (III) and Nd (III) were found to be more potent inhibitors against Pseudomonas aeruginosa than two of commonly used antibiotics. The remaining Ln (III) complexes showed no remarkable activity as compared to the two standard drugs used.


CONCLUSIONS
Tetradentate Schiff base ligand L and its complexes could be a potential antibacterial compounds after further investigation.
['Al Momani|Waleed Mahmoud|WM|', 'Taha|Ziyad Ahmed|ZA|', 'Ajlouni|Abdulaziz Mahmoud|AM|', 'Shaqra|Qasem Mohammad Abu|QM|', 'Al Zouby|Muaz|M|']
D000900:Anti-Bacterial Agents D001419:Bacteria D052978:Disk Diffusion Antimicrobial Tests D028581:Lanthanoid Series Elements D008024:Ligands D008826:Microbial Sensitivity Tests D012545:Schiff Bases
Antimicrobial Biomolecules Organics Synthetic ligands