Two pairs of phenolic enantiomers from the leaves of Eucommia ulmoides Oliver.
Two pairs of new phenolic enantiomers, (+)-eucophenolic A (1a), (-)-eucophenolic B (1b), (-)-eucophenolic C (2a), (+)-eucophenolic D (2b) were isolated from the leaves of Eucommia ulmodies Oliver by chiral enantiomeric resolution. Their structures were elucidated based on extensive spectroscopic analysis. The absolute configurations of 1a/1b and 2a/2b were determined by empirical method and the calculated ECD and OR. All compounds were tested for Hep G2 tumour cell lines. However, no compounds showed potential cytotoxic activities against Hep G2 in vitro.
['Yan|Jian-Kun|JK|', 'Shi|Xu-Liu|XL|', 'Donkor|Paul Owusu|PO|', 'Gao|Xiu-Mei|XM|', 'Ding|Li-Qin|LQ|', 'Qiu|Feng|F|']
D004354:Drug Screening Assays, Antitumor D031283:Eucommiaceae D056945:Hep G2 Cells D006801:Humans D015394:Molecular Structure D010636:Phenols D018515:Plant Leaves D013057:Spectrum Analysis D013237:Stereoisomerism
Phenolic enantiomers ECD and OR Hep G2 leaves of  Oliver