The stability of blood Eosinophils in chronic obstructive pulmonary disease.
Blood eosinophils are a predictive biomarker of inhaled corticosteroid response in chronic obstructive pulmonary disease (COPD). We investigated blood eosinophil stability over 1 year using the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2019 thresholds of < 100, 100- < 300 and ≥ 300 eosinophils/μL in 225 patients from the COPDMAP cohort. Blood eosinophils showed good stability (rho: 0.71, p < 0.001, ICC 0.84), and 69.3% of patients remained in the same eosinophil category at 1 year. 85.3% of patients with eosinophils < 100 cells/μL had stable counts. The majority of blood eosinophil counts remain stable over 1 year using the GOLD 2019 thresholds.
['Long|Gabriella H|GH|http://orcid.org/0000-0001-9286-2887', 'Southworth|Thomas|T|', 'Kolsum|Umme|U|', 'Donaldson|Gavin C|GC|', 'Wedzicha|Jadwiga A|JA|', 'Brightling|Christopher E|CE|', 'Singh|Dave|D|']
D000280:Administration, Inhalation D000368:Aged D001993:Bronchodilator Agents D004804:Eosinophils D005260:Female D006801:Humans D007958:Leukocyte Count D008297:Male D008875:Middle Aged D029424:Pulmonary Disease, Chronic Obstructive
Eosinophil COPD Airway inflammation