Coagulation disorders in coronavirus infected patients: COVID-19, SARS-CoV-1, MERS-CoV and lessons from the past.
Coronavirus disease 2019 (COVID-19) or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus strain disease, has recently emerged in China and rapidly spread worldwide. This novel strain is highly transmittable and severe disease has been reported in up to 16% of hospitalized cases. More than 600,000 cases have been confirmed and the number of deaths is constantly increasing. COVID-19 hospitalized patients, especially those suffering from severe respiratory or systemic manifestations, fall under the spectrum of the acutely ill medical population, which is at increased venous thromboembolism risk. Thrombotic complications seem to emerge as an important issue in patients infected with COVID-19. Preliminary reports on COVID-19 patients' clinical and laboratory findings include thrombocytopenia, elevated D-dimer, prolonged prothrombin time, and disseminated intravascular coagulation. As the pandemic is spreading and the whole picture is yet unknown, we highlight the importance of coagulation disorders in COVID-19 infected patients and review relevant data of previous coronavirus epidemics caused by the severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and the Middle East Respiratory Syndrome coronavirus (MERS-CoV).
['Giannis|Dimitrios|D|', 'Ziogas|Ioannis A|IA|', 'Gianni|Panagiota|P|']
D000818:Animals D001778:Blood Coagulation Disorders D000086382:COVID-19 D002681:China D018352:Coronavirus Infections D004211:Disseminated Intravascular Coagulation D005338:Fibrin Fibrinogen Degradation Products D006801:Humans D051379:Mice D065207:Middle East Respiratory Syndrome Coronavirus D058873:Pandemics D011024:Pneumonia, Viral D045169:Severe Acute Respiratory Syndrome D013921:Thrombocytopenia
coagulation coronavirus COVID-19 MERS-CoV SARS-CoV thrombosis