Carbendazim-induced testicular damage and oxidative stress in albino rats: ameliorative effect of licorice aqueous extract.
Carbendazim is a broad spectrum carbamate fungicide used in the control of various fungal pathogens. Licorice (Glycyrrhiza glabra) is one of the widely used medicinal plants in oriental nations. The present work studied the effect of licorice aqueous extract on carbendazim-induced testicular toxicity in albino rats. Administration of carbendazim induced significant decrease in testis weight, diameter, and germinal epithelial height of the seminiferous tubules. Histological results revealed degeneration of seminiferous tubules, loss of spermatogenic cells, and apoptosis. Moreover, carbendazim caused elevation of testicular malondialdehyde (MDA), marker of lipid peroxidation, and reduced the activity of the antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Coadministration of licorice extract with carbendazim improved the histomorphological and histopathological changes observed in animals treated with carbendazim. In addition, licorice treatment leads to a significant decrease in the level of MDA and increase in the activities of SOD and CAT. According to the present results, it is concluded that licorice aqueous extract can improve the testicular toxicity of carbendazim and this effect may be attributed to antioxidant properties of one or more of its constituents.
['Sakr|Saber A|SA|', 'Shalaby|Somaya Y|SY|']
D000818:Animals D001562:Benzimidazoles D002219:Carbamates D002374:Catalase D006035:Glycyrrhiza D008297:Male D008315:Malondialdehyde D009929:Organ Size D018384:Oxidative Stress D010936:Plant Extracts D020011:Protective Agents D051381:Rats D017208:Rats, Wistar D012671:Seminiferous Tubules D013482:Superoxide Dismutase D013733:Testicular Diseases D013737:Testis
licorice Carbendazim testis histology antioxidant