Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes.
AIMS
There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts.


METHODS AND RESULTS
In a community-based pooled cohort, we followed 107 845 individuals for the association between alcohol consumption, including types of alcohol and drinking patterns, and incident AF. We collected information on classical cardiovascular risk factors and incident heart failure (HF) and measured the biomarkers N-terminal pro-B-type natriuretic peptide and high-sensitivity troponin I. The median age of individuals was 47.8 years, 48.3% were men. The median alcohol consumption was 3 g/day. N = 5854 individuals developed AF (median follow-up time: 13.9 years). In a sex- and cohort-stratified Cox regression analysis alcohol consumption was non-linearly and positively associated with incident AF. The hazard ratio for one drink (12 g) per day was 1.16, 95% CI 1.11-1.22, P < 0.001. Associations were similar across types of alcohol. In contrast, alcohol consumption at lower doses was associated with reduced risk of incident HF. The association between alcohol consumption and incident AF was neither fully explained by cardiac biomarker concentrations nor by the occurrence of HF.


CONCLUSIONS
In contrast to other cardiovascular diseases such as HF, even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of AF, which needs to be considered in AF prevention.
['Csengeri|Dora|D|', 'Sprünker|Ngoc-Anh|NA|', 'Di Castelnuovo|Augusto|A|', 'Niiranen|Teemu|T|', 'Vishram-Nielsen|Julie Kk|JK|', 'Costanzo|Simona|S|', 'Söderberg|Stefan|S|', 'Jensen|Steen M|SM|', 'Vartiainen|Erkki|E|', 'Donati|Maria Benedetta|MB|', 'Magnussen|Christina|C|', 'Camen|Stephan|S|', 'Gianfagna|Francesco|F|', 'Løchen|Maja-Lisa|ML|', 'Kee|Frank|F|', 'Kontto|Jukka|J|', 'Mathiesen|Ellisiv B|EB|', 'Koenig|Wolfgang|W|', 'Stefan|Blankenberg|B|', 'de Gaetano|Giovanni|G|', 'Jørgensen|Torben|T|', 'Kuulasmaa|Kari|K|', 'Zeller|Tanja|T|', 'Salomaa|Veikko|V|', 'Iacoviello|Licia|L|', 'Schnabel|Renate B|RB|']
D000428:Alcohol Drinking D001281:Atrial Fibrillation D015415:Biomarkers D015331:Cohort Studies D005260:Female D006333:Heart Failure D006801:Humans D015994:Incidence D008297:Male D008875:Middle Aged D018570:Risk Assessment D012307:Risk Factors
Alcohol consumption Biomarkers Atrial fibrillation Epidemiology