Phase II trial of preoperative sequential chemotherapy followed by chemoradiotherapy for high-risk gastric cancer.
BACKGROUND AND PURPOSE
To evaluate the safety and efficacy of preoperative chemotherapy (CTx) followed by chemoradiotherapy (CCRT) for high-risk gastric cancer (GC).


METHODS AND MATERIALS
The inclusion criteria were as follows: (1) Borrmann type 4; (2) large Borrmann type 3 (≥8 cm); (3) single bulky (≥3 cm × 1) or multiple lymph nodes (≥1.5 cm × 3). Patients received two 21-day courses of induction CTx of TS-1 (35 mg/m2, p.o, twice daily on days 1-14), docetaxel (30 mg/m2, i.v., days 1 and 8), and cisplatin (30 mg/m2, i.v., days 1 and 8) followed by CCRT (two courses of TS-1 and cisplatin in combination with 45 Gy radiation).


RESULTS
Forty-two patients were enrolled between March 2014 and February 2016, and 39 of these completed sequential CTx and CCRT. Among the 33 patients who underwent R0 resection, the pathologic response rate was 39.4% [no residual carcinoma (n = 5, 15.2%), with 1-10% residual carcinoma (n = 8, 24.2%)]. Overall, 4 patients (12.1%) were pathologic stage 0, 7 (21.2%) were stage I, 10 (30.3%) were stage II, and 12 (36.4%) were stage III. The overall survival rate at 3 years was 77.9% for stages 0 and I, 66.8% for stages II-III, and 33.3% for unresectable cases (P = 0.001). Toxicity was mild to moderate with grade 4 neutropenia (n = 1) and neutropenic fever (n = 1) as the most prominent side-effects.


CONCLUSIONS
Sequential CTx and CCRT prior to surgery are feasible and effective for high-risk GC.


TRIAL REGISTRATION NUMBER
NCT02495493.
['Kim|Hyo Song|HS|', 'Koom|Woong Sub|WS|', 'Baek|Song-Ee|SE|', 'Kim|Hyoung-Il|HI|', 'Jung|Minkyu|M|', 'Beom|Seung-Hoon|SH|', 'Kang|Beodeul|B|', 'Kim|Hyunki|H|', 'Chang|Jee Suk|JS|', 'Choi|Yoon Young|YY|', 'Son|Taeil|T|', 'Cheong|Jae-Ho|JH|', 'Noh|Sung Hoon|SH|', 'Kim|Eun Hye|EH|', 'Park|Jun Chul|JC|', 'Shin|Sung Kwan|SK|', 'Lee|Sang Kil|SK|', 'Lee|Yong Chan|YC|', 'Shin|Su-Jin|SJ|', 'Chung|Hyunsoo|H|', 'Jung|Inkyung|I|', 'Chung|Hyun Cheol|HC|', 'Lim|Joon Seok|JS|', 'Hyung|Woo Jin|WJ|', 'Rha|Sun Young|SY|']
D000328:Adult D000368:Aged D000971:Antineoplastic Combined Chemotherapy Protocols D059248:Chemoradiotherapy D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D009367:Neoplasm Staging D013274:Stomach Neoplasms
Gastric cancer Preoperative chemotherapy Preoperative chemoradiotherapy