Renal transplantation outcomes following heart and heart-lung transplantation.
BACKGROUND
Chronic kidney disease is a frequent complication following heart and combined heart-lung transplantation. The aim of this study was to analyse the outcome of a subsequent renal transplant in heart, lung and heart-lung transplantation recipients.


METHODS
All heart, lung and heart-lung transplant recipients who received a subsequent renal transplant over a 27-year period in a national heart and lung transplant centre were included in this study.


RESULTS
A total of 18 patients who had previously undergone heart (n = 6), lung (n = 7) and heart-lung (n = 5) transplantation received a renal transplant. The mean duration to development of end-stage kidney disease (ESKD) was 115 ± 45.9 months. The most common contributor to ESKD was calcineurin inhibitor nephrotoxicity. The 5-year patient survival and graft survival rates were 91.7 and 85.6%, respectively. The median creatinine level at the most recent follow-up was 123 μmol/L, IQR 90.8-147.5.


CONCLUSIONS
The overall outcome of renal transplantation following previous non-renal solid organ transplantation is excellent considering the medical complexity and co-morbidities of this patient population. Renal transplantation represents an important treatment option for ESKD in non-renal solid organ transplant recipients.
['Wong|L|L|', 'Chee|Y R|YR|', 'Healy|D G|DG|', 'Egan|J J|JJ|', 'Sadlier|D M|DM|', "O'Meara|Y M|YM|"]
D005260:Female D016027:Heart Transplantation D016041:Heart-Lung Transplantation D006801:Humans D016030:Kidney Transplantation D008297:Male D051436:Renal Insufficiency, Chronic D012189:Retrospective Studies D015996:Survival Rate D016896:Treatment Outcome
Renal transplant Outcomes Heart Lung