Do females behave differently in COPD exacerbation?
INTRODUCTION
Little is known about whether there is any sex effect on chronic obstructive lung disease (COPD) exacerbations. This study is intended to describe the possible sex-associated differences in exacerbation profile in COPD patients.


METHODS
A total of 384 COPD patients who were hospitalized due to exacerbation were evaluated retrospectively for their demographics and previous and current exacerbation characteristics.


RESULTS
The study was conducted on 109 (28%) female patients and 275 (72%) male patients. The mean age was 68.30±10.46 years. Although females had better forced expiratory volume in 1 second and near-normal forced vital capacity, they had much impaired arterial blood gas levels (partial oxygen pressure [PO2] was 36.28 mmHg vs 57.93 mmHg; partial carbon dioxide pressure [PCO2] was 45.97 mmHg vs 42.49 mmHg; P=0.001), indicating severe exacerbation with respiratory failure. More females had two exacerbations and two hospitalizations, while more men had one exacerbation and one hospitalization. Low adherence to treatment and pulmonary embolism were more frequent in females. Females had longer time from the onset of symptoms till the admission and longer hospitalization duration than males. Comorbidities were less in number and different in women (P<0.05). Women were undertreated and using more oral corticosteroids.


CONCLUSION
Current data showed that female COPD patients might be more prone to have severe exacerbations, a higher number of hospitalizations, and prolonged length of stay for hospitalization. They have a different comorbidity profile and might be undertreated for COPD.
['Kilic|Hatice|H|', 'Kokturk|Nurdan|N|', 'Sari|Gulcin|G|', 'Cakır|Mustafa|M|']
D000284:Administration, Oral D000305:Adrenal Cortex Hormones D000368:Aged D000900:Anti-Bacterial Agents D001784:Blood Gas Analysis D015897:Comorbidity D003430:Cross-Sectional Studies D018450:Disease Progression D005260:Female D005541:Forced Expiratory Volume D006304:Health Status D054624:Health Status Disparities D054625:Healthcare Disparities D006801:Humans D007902:Length of Stay D008168:Lung D008297:Male D055118:Medication Adherence D008875:Middle Aged D010359:Patient Readmission D029424:Pulmonary Disease, Chronic Obstructive D012189:Retrospective Studies D012307:Risk Factors D012737:Sex Factors D013997:Time Factors D016896:Treatment Outcome D014797:Vital Capacity
female COPD exacerbation sex comorbidities