Increased muscle force production and bone mineral density in ActRIIB-Fc-treated mature rodents.
Myostatin is a highly conserved member of the transforming growth factor-β ligand family known to regulate muscle growth via activation of activin receptors. A fusion protein consisting of the extracellular ligand-binding domain of activin type IIB receptor with the Fc portion of human immunoglobulin G (ActRIIB-Fc) was used to inhibit signaling through this pathway. Here, we study the effects of this fusion protein in adult, 18-month-old, and orchidectomized mice. Significant muscle growth and enhanced muscle function were observed in adult mice treated for 3 days with ActRIIB-Fc. The ActRIIB-Fc-treated mice had enhanced fast fatigable muscle function, with only minor enhancement of fatigue-resistant fiber function. The ActRIIB-Fc-treated 18-month-old mice and orchidectomized mice showed significantly improved muscle function. Treatment with ActRIIB-Fc also increased bone mineral density and serum levels of a marker of bone formation. These observations highlight the potential of targeting ActRIIB receptor to treat age-related and hypogonadism-associated musculoskeletal degeneration.
['Chiu|Chi-Sung|CS|', 'Peekhaus|Norbert|N|', 'Weber|Hans|H|', 'Adamski|Sharon|S|', 'Murray|Edward M|EM|', 'Zhang|Hai Zhuan|HZ|', 'Zhao|Jing Zhang|JZ|', 'Ernst|Robin|R|', 'Lineberger|Janet|J|', 'Huang|Lingyi|L|', 'Hampton|Richard|R|', 'Arnold|Beth Anne|BA|', 'Vitelli|Salvatore|S|', 'Hamuro|Lora|L|', 'Wang|Wei-Rong|WR|', 'Wei|Nan|N|', 'Dillon|Greg M|GM|', 'Miao|Jiangyong|J|', 'Alves|Stephen E|SE|', 'Glantschnig|Helmut|H|', 'Wang|Fubao|F|', 'Wilkinson|Hilary A|HA|']
D030301:Activin Receptors, Type II D000375:Aging D000818:Animals D015415:Biomarkers D015519:Bone Density D002460:Cell Line D057809:HEK293 Cells D006801:Humans D007141:Immunoglobulin Fc Fragments D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D009119:Muscle Contraction D053580:Muscle Strength D055435:Myostatin D009919:Orchiectomy D010446:Peptide Fragments D011347:Procollagen D011993:Recombinant Fusion Proteins D055948:Sarcopenia
Muscle Myostatin Activin receptor type IIB Sarcopenia