Influence of different modifications of a calcium phosphate cement on resorption and new bone formation: an in vivo study in the minipig.
Calcium phosphate cements (CPCs) are established in surgery as temporary bone replacement materials. The most common and important class of CPC, transformed into nanocrystalline hydroxyapatite after setting, is characterized by good biocompatibility and osteoconductivity. However, acceleration of remodelling is in the focus of ongoing research. In the present study, the bone healing efficacy of Biocement D (BioD) modified with mineralized collagen alone (BioD/coll) or in combination with osteocalcin (BioD/coll/OC), O-phospho-L-serine (BioD/coll/PS), sodium citrate (BioD/coll/cit), and polylactide (BioD/coll/PL), respectively, was evaluated in a large animal model. Resorption of the bone substitutes and new bone formation were studied in cyst-like jaw defects of minipigs after filling with the unmodified BioD and the modified BioD variants, respectively. Histomorphometric analysis revealed small differences between the different cement types with respect to resorption. However, new bone formation was improved in case of defects repaired with BioD/coll/OC and BioD/coll/PS and slightly improved in case of BioD/coll and BioD/coll/PL.
['Tödtmann|Ninette|N|', 'Lode|Anja|A|', 'Mann|Romy|R|', 'Mai|Ronald|R|', 'Lauer|Günter|G|', 'Wieczorek|Kathrin|K|', 'Eckelt|Uwe|U|']
D000818:Animals D001672:Biocompatible Materials D001843:Bone Cements D001861:Bone Regeneration D016723:Bone Remodeling D018786:Bone Substitutes D002130:Calcium Phosphates D002417:Cattle D003094:Collagen D017886:Durapatite D005260:Female D008422:Materials Testing D023421:Models, Animal D015675:Osteocalcin D010012:Osteogenesis D013552:Swine D013556:Swine, Miniature
animal model biodegradation bone remodeling calcium phosphate(s) histomorphometry