Validity of arterialised-venous P CO2, pH and bicarbonate in obesity hypoventilation syndrome.
This prospective study investigated the validity of arterialised-venous blood gases (AVBG) for estimating arterial carbon dioxide P CO2, pH and bicarbonate (HCO3(-)) in people with obesity hypoventilation syndrome (OHS). AVBGs were obtained from an upper limb vein, after heating the skin at 42-46°C. Arterial blood gas (ABG) and AVBG samples were taken simultaneously and compared using Bland Altman analysis. Between-group differences were assessed with independent t-tests or Mann-Whitney U tests. Forty-two viable paired samples were analysed, including 27 paired samples from 15 OHS participants, and 15 paired samples from 16 controls. AVBG-ABG agreement was not different between groups, or between dorsal hand, forearm and antecubital AVBG sampling sites, and was clinically acceptable for P Co2: mean difference (MD) 0.4 mmHg (0.9%), limits of agreement (LOA) -2.7-3.6 mmHg (± 6.6%); pH: MD -0.008 (-0.1%), LOA -0.023-0.008 (± 0.2%); and HCO3(-): MD -0.3 mmol L(-1) (-1.0%), LOA -1.8-1.2 mmol L(-1) (± 5.3%). AVBG provides valid measures of [Formula: see text] , pH, and HCO3(-) in OHS.
['Hollier|Carly A|CA|', 'Maxwell|Lyndal J|LJ|', 'Harmer|Alison R|AR|', 'Menadue|Collette|C|', 'Piper|Amanda J|AJ|', 'Black|Deborah A|DA|', 'Willson|Grant N|GN|', 'Alison|Jennifer A|JA|']
D000328:Adult D001158:Arteries D001639:Bicarbonates D001784:Blood Gas Analysis D002245:Carbon Dioxide D005260:Female D006801:Humans D006863:Hydrogen-Ion Concentration D008297:Male D008875:Middle Aged D010845:Obesity Hypoventilation Syndrome D015203:Reproducibility of Results D018709:Statistics, Nonparametric D014680:Veins
Validation Arterialised-venous bicarbonate Obesity Obesity hypoventilation syndrome Obesity hypoventilation syndrome AVBG Carbon dioxide OHS °C arterial blood gas Blood gas ABG mean difference MD limits of agreement LOA %bias %error CI CO(2) HCO(3)(−) HRF O(2) Oxygen PAP SD arterial partial pressure of carbon dioxide arterialised-venous blood gas arterialised-venous partial pressure of carbon dioxide confidence interval degrees celsius hypercapnic respiratory failure limits of agreement represented as a percentage mean difference represented as a percentage obesity hypoventilation syndrome partial pressure of carbon dioxide positive airway pressure standard deviation