Distinct function of miR-17-92 cluster in the dorsal and ventral adult hippocampal neurogenesis.
It has been known that the dorsal and ventral areas of the dentate gyrus in the hippocampus have distinct roles in memory and mood behaviors. We previously reported that microRNA miR-17-92 regulates adult hippocampal neurogenesis and mood disorders. Here, we suggest that the miR-17-92 cluster is highly expressed in the ventral than the dorsal dentate gyrus in the adult mouse hippocampus. Deletion of miR-17-92 in the adult hippocampus only affects development of neural progenitors in the ventral dentate gyrus, and miR-17-92 knockout mice have no defects in memory functions. Our results suggest that regional expression of miR-17-92 in the dentate gyrus is associated with their distinct functions in hippocampal neurogenesis and related behaviors.
['Jin|Junghee|J|', 'Ko|Heejae|H|', 'Sun|Tao|T|', 'Kim|Seung-Nam|SN|']
D000818:Animals D018891:Dentate Gyrus D005260:Female D006624:Hippocampus D008297:Male D051379:Mice D018345:Mice, Knockout D008822:Mice, Transgenic D035683:MicroRNAs D055495:Neurogenesis
Distinct function miR-17-92 cluster Dentate gyrus Hippocampus Regional expression