Nox2 activation in Covid-19.
Nox2 is responsible for artery dysfunction via production of reactive oxidant species. RNA viruses may activate Nox2, but it is unknown if this occurs in coronavirus 2019(Covid-19). Nox2 activation by soluble Nox2-derived peptide(sNox2-dp) was measured in patients hospitalized for Covid-19 (n = 182) and controls (n = 91). sNox2-dp values were higher in Covid-19 patients versus controls and in severe versus non severe Covid-19. Patients with thrombotic events(n = 35,19%) had higher sNox2-dp than thrombotic event-free ones. A logistic regression analysis showed that sNox2 and coronary heart disease predicted thrombotic events. Oxidative stress by Nox2 activation is associated severe disease and thrombotic events in Covid-19 patients.
['Violi|Francesco|F|', 'Oliva|Alessandra|A|', 'Cangemi|Roberto|R|', 'Ceccarelli|Giancarlo|G|', 'Pignatelli|Pasquale|P|', 'Carnevale|Roberto|R|', 'Cammisotto|Vittoria|V|', 'Lichtner|Miriam|M|', 'Alessandri|Francesco|F|', 'De Angelis|Massimiliano|M|', 'Miele|Maria Claudia|MC|', "D'Ettorre|Gabriella|G|", 'Ruberto|Franco|F|', 'Venditti|Mario|M|', 'Pugliese|Francesco|F|', 'Mastroianni|Claudio Maria|CM|']
D000368:Aged D015415:Biomarkers D000086382:COVID-19 D018352:Coronavirus Infections D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D000074662:NADPH Oxidase 2 D018384:Oxidative Stress D058873:Pandemics D010446:Peptide Fragments D011024:Pneumonia, Viral D013927:Thrombosis
Covid-19 NADPH oxidase Nox-2 Thrombosis