Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH)--An uncommon precursor of a common cancer?
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare, likely under recognized entity. We report on six cases of DIPNECH that were seen in Saskatoon, SK. The cases largely have the characteristics of the typical patient profile thus far described in the literature, consistent with the limited information reported to date. Furthermore, one case had co-existing squamous cell carcinoma, which has not been previously described, and one case had concomitant adenocarcinoma. In this context, we explore the hypothesis of whether DIPNECH could play a role as an uncommon precursor in pulmonary tumorigenesis. We also propose improved diagnostic criteria for DIPNECH, which are currently ill-defined.
['Baniak|Nick M|NM|', 'Wilde|Brent|B|', 'Kanthan|Rani|R|']
D000230:Adenocarcinoma D000077192:Adenocarcinoma of Lung D000368:Aged D000369:Aged, 80 and over D002471:Cell Transformation, Neoplastic D018450:Disease Progression D005260:Female D006801:Humans D006965:Hyperplasia D008175:Lung Neoplasms D008297:Male D008875:Middle Aged D018307:Neoplasms, Squamous Cell D055099:Neuroendocrine Cells D011230:Precancerous Conditions D012525:Saskatchewan
DIPNECH Squamous cell carcinoma Adenocarcinoma Tumorigenesis Diagnostic criteria Tumorlet/carcinoid