Inhibition of suilysin activity and inflammation by myricetin attenuates Streptococcus suis virulence.
Streptococcus suis (S. suis) is a gram-positive, zoonotic pathogenic bacterium that poses a serious threat to the pig industry and human health. This globally distributed pathogen can cause multiple diseases and fatal infections in both humans and animals. Suilysin (SLY) is an important extracellular secreted toxin regarded as an essential S. suis capsular type 2 (SS2) virulence factor and plays a key role in the infection and cytotoxicity of SS2. In addition, an excessive inflammatory response is also a serious hazard caused by SS2 infection. In this study, we demonstrated that the natural compound myricetin can inhibit the hemolytic activity of SLY and is effective at reducing the production of the inflammatory cytokines TNF-α and IL-1β and reducing inflammation by downregulating the activation of P38. In addition, myricetin could effectively treat SS2 infections in vitro and in vivo. These findings may aid in the development of promising therapeutic candidates for treating SS2 infections.
['Li|Gen|G|', 'Wang|Guizhen|G|', 'Si|Xiaosa|X|', 'Zhang|Xueke|X|', 'Liu|Wentao|W|', 'Li|Li|L|', 'Wang|Jianfeng|J|']
D000818:Animals D002460:Cell Line D002470:Cell Survival D004195:Disease Models, Animal D005260:Female D005419:Flavonoids D006460:Hemolysin Proteins D007249:Inflammation D008264:Macrophages D008810:Mice, Inbred C57BL D008826:Microbial Sensitivity Tests D013290:Streptococcal Infections D017011:Streptococcus suis D014774:Virulence D037521:Virulence Factors
Suilysin Myricetin Streptococcus suis Antivrulence Inflamation