AS1411 aptamer-targeted gold nanoclusters effect on the enhancement of radiation therapy efficacy in breast tumor-bearing mice.
AIM
Herein, the AS1411 aptamer-targeted ultrasmall gold nanoclusters (GNCs) were assessed at different aspects as a radiosensitizer.


MATERIALS & METHODS
AS1411 aptamer-conjugated gold nanoclusters (Apt-GNCs) efficacy was evaluated at cancer cells targeting, radiosensitizing effect, tumor targeting, and biocompatibility in breast tumor-bearing mice.


RESULTS
Flow cytometry and fluorescence microscopy exhibited more cellular uptake for Apt-GNCs in comparison with GNCs. In addition, inductively coupled plasma optical emission spectrometry results demonstrated its effective tumor targeting as the tumors' gold content for GNCs and Apt-GNCs were 8.53 and 15.33 μg/g, respectively. Apt-GNCs significantly enhanced radiotherapy efficacy as mean tumors' volume decreased about 39% and 9 days increase in the mice survival was observed. Both GNCs and Apt-GNCs were biocompatible.


CONCLUSION
The Apt-GNCs is a novel and efficient  radiosensitizer.
['Ghahremani|Fatemeh|F|', 'Kefayat|Amirhosein|A|', 'Shahbazi-Gahrouei|Daryoush|D|', 'Motaghi|Hasan|H|', 'Mehrgardi|Masoud A|MA|', 'Haghjooy-Javanmard|Shaghayegh|S|']
D000818:Animals D052157:Aptamers, Nucleotide D001943:Breast Neoplasms D045744:Cell Line, Tumor D016503:Drug Delivery Systems D005260:Female D005434:Flow Cytometry D006801:Humans D053768:Metal Nanoparticles D051379:Mice D009838:Oligodeoxyribonucleotides D011838:Radiation-Sensitizing Agents
gold nanoclusters radiation therapy radiosensitizer cancer tumor targeting biocompatibility 4T1 AS1411 aptamer breast tumors nucleolin