Enhanced chemiluminescence for trazodone trace analysis based on acidic permanganate oxidation in concurrent presence of rhodamine 6G.
A new sensitized chemiluminescence method by acidic permanganate oxidation was developed for the sensitive determination of trazodone. A fluorescent dye as used rhodamine 6G to increase a chemiluminescence intensity. Under optimum conditions, the liner range of the calibration curve was obtained for 1-5000 nmol/L. The limit of detection was calculated from 3σ of a blank was 0.23 nmol/L. The coexistent ions and substances had no interference with the chemiluminescence measurement. The chemiluminescence spectra were measured to elucidate a possible mechanism for the system. The present method was satisfactorily used in the determination of the drugs in pharmaceutical samples and animal serums.
['Fujimori|Keiichi|K|http://orcid.org/0000-0001-5055-7956', 'Sakata|Yuta|Y|', 'Moriuchi-Kawakami|Takayo|T|', 'Shibutani|Yasuhiko|Y|']
D000818:Animals D002138:Calibration D005456:Fluorescent Dyes D007700:Kinetics D057230:Limit of Detection D008163:Luminescent Measurements D017895:Manganese Compounds D010084:Oxidation-Reduction D010087:Oxides D012235:Rhodamines D013607:Tablets D014196:Trazodone
trazodone sensitized chemiluminescence rhodamine 6G