Activity of the Novel Fungicide SYP-34773 against Plant Pathogens and Its Mode of Action on Phytophthora infestans.
SYP-34773 is a pyrimidinamine derivative and a novel fungicide modified from diflumetorim. This study determined the antimicrobial spectrum of SYP-34773, which showed it could strongly inhibit the growth of some important plant pathogens including fungi and oomycetes. In particular, Phytophthora infestans is an oomycete sensitive to SYP-34773, and the mycelium growth stage was found to be the most sensitive stage, with an EC50 value of 0.2030 μg/mL. At a concentration of 200 μg/mL, SYP-34773 displayed an excellent control efficacy of 69.55% and 81.48% against potato and tomato blight disease caused by P. infestans under field conditions, respectively. Mode of action investigations showed that this fungicide could cause severe ultrastructure damage to the mycelia of P. infestans, inhibit its respiration, and increase the cell membrane permeability of this pathogen. The results of this study could provide useful information for the fungicide registration and application of SYP-34773 as a novel fungicide.
['Wang|Weizhen|W|https://orcid.org/0000-0001-7549-8374', 'Liu|Ying|Y|', 'Xue|Zhaolin|Z|https://orcid.org/0000-0003-2469-7968', 'Li|Jingru|J|', 'Wang|Zhiwen|Z|', 'Liu|Xili|X|']
D005659:Fungicides, Industrial D018551:Lycopersicon esculentum D055750:Phytophthora infestans D010935:Plant Diseases D011198:Solanum tuberosum
fungicide SYP-34773 mode of action Phytophthora infestans antimicrobial spectrum oomycete