Influence of lung transplantation on the essential fatty acid profile in cystic fibrosis.
Lung transplantation is assumed to normalize essential fatty acid (EFA) profile in the plasma, described as abnormal in patients with cystic fibrosis (CF). This study sought to evaluate the EFA profile in both the plasma and erythrocyte membrane according to lung status by comparing CF patients with or without a lung transplant. A total of 50 homozygous F508del patients (33 CF patients [CF group] and 17 CF patients with a lung transplant [TX CF group]) were included. In comparison with the CF group, in the plasma, the levels of total n-3, α-linolenic, eicosapentaenoic, and docosahexaenoic acids were higher and the n-6/n-3 ratio was lower in the TX CF group. Yet, these differences were not observed in the erythrocyte membrane. This study supports that lung transplantation improves the EFA profile in the plasma but not in the erythrocyte membrane by means of the different mechanisms suggested in this article.
['Hanssens|Laurence|L|', 'Duchateau|J|J|', 'Namane|S A|SA|', 'Malfroot|A|A|', 'Knoop|C|C|', 'Casimir|G|G|']
D000293:Adolescent D000328:Adult D002648:Child D003550:Cystic Fibrosis D004910:Erythrocyte Membrane D005228:Fatty Acids, Essential D005260:Female D006720:Homozygote D006801:Humans D016040:Lung Transplantation D008297:Male D010949:Plasma D011446:Prospective Studies D055815:Young Adult
Lung transplantation Essential fatty acid Cystic fibrosis Polyunsaturated fatty acids