Pure red cell aplasia caused by pegylated interferon-α-2a plus ribavirin in the treatment of chronic hepatitis C.
Pure red cell aplasia (PRCA) is a rare hematological disorder which is characterized by severe anemia, reticulocytopenia and almost complete absence of erythroid precursors in bone marrow. The pathophysiology of PRCA may be congenital or acquired. To our knowledge, there is only one case report in the English literature of PRCA after pegylated interferon combination therapy for chronic hepatitis C. We report a second case of PRCA after pegylated interferon combination treatment for chronic hepatitis C. The diagnosis of PRCA was confirmed by the typical findings of bone marrow biopsy. The possible etiologies of our case are also discussed in this paper.
['Chang|Cheng-Shyong|CS|', 'Yan|Sheng-Lei|SL|', 'Lin|Hsuan-Yu|HY|', 'Yu|Fu-Lien|FL|', 'Tsai|Chien-Yu|CY|']
D000368:Aged D000998:Antiviral Agents D001854:Bone Marrow Cells D004359:Drug Therapy, Combination D019698:Hepatitis C, Chronic D006801:Humans D000077190:Interferon alpha-2 D016898:Interferon-alpha D008297:Male D011092:Polyethylene Glycols D011994:Recombinant Proteins D012010:Red-Cell Aplasia, Pure D012254:Ribavirin
Pure red cell aplasia Pegylated interferon-α-2a Ribavirin Chronic hepatitis C