Characterization of Large Deletion Mutants of Mycobacterium tuberculosis Selected for Isoniazid Resistance.
Large genomic deletions (LGDs) (6 to 63 kbp) were observed in isoniazid-resistant Mycobacterium tuberculosis mutants derived from four M. tuberculosis strains. These LGDs had no growth defect in vitro but could be defective in intracellular growth and showed various sensitivities toward oxidative stress despite lacking katG The LGD regions comprise 74 genes, mostly of unknown function, that may be important for M. tuberculosis intracellular growth and protection against oxidative stress.
['Vilchèze|Catherine|C|', 'Saranathan|Rajagopalan|R|', 'Weinrick|Brian|B|0000-0003-0880-4487', 'Jacobs|William R|WR|0000-0003-3321-3080']
D000995:Antitubercular Agents D001426:Bacterial Proteins D002374:Catalase D024881:Drug Resistance, Bacterial D007538:Isoniazid D009154:Mutation D009169:Mycobacterium tuberculosis
deletion isoniazid resistance arginine