Reflexin A, a new indole alkaloid from Rauvolfia reflexa induces apoptosis against colon cancer cells.
One new indole alkaloid, reflexin A (1), and two known indoles, macusine B (2) and vinorine (3), were isolated from the bark of Rauvolfia reflexa. Their structures were elucidated by 1D and 2D NMR, UV, IR, and MS spectroscopic analyses. Compound 1 displayed anticancer activity against HCT-116 colon cancer cells with an IC50 value of 30.24 ± 0.75 µM. The results implied that the newly isolated 1 induced apoptosis in HCT-116 cells, suggesting its possible role as an anticancer agent. In vivo acute toxicity study was performed on compound 1 to evaluate its safety profile.
['Fadaeinasab|Mehran|M|http://orcid.org/0000-0002-2501-894X', 'Karimian|Hamed|H|http://orcid.org/0000-0002-8501-9864', 'Omar|Hanita|H|', 'Taha|Hairin|H|', 'Khorasani|Arash|A|', 'Banisalam|Behrooz|B|', 'Aziz Ketuly|Kamal|K|', 'Abdullah|Zanariah|Z|']
D017209:Apoptosis D003110:Colonic Neoplasms D044950:Flavanones D006801:Humans D026121:Indole Alkaloids D015394:Molecular Structure D011926:Rauwolfia
reflexin A indole alkaloids Rauvolfia reflexa apoptosis HCT-116 cells acute toxicity