Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism.
Hematopoietic stem cells (HSCs) reside in a hypoxic microenvironment that enables glycolysis-fueled metabolism and reduces oxidative stress. Nonetheless, metabolic regulation in organelles such as the mitochondria and lysosomes as well as autophagic processes have been implicated as essential for the determination of HSC cell fate. This review encompasses the current understanding of anaerobic metabolism in HSCs as well as the emerging roles of mitochondrial metabolism and lysosomal regulation for hematopoietic homeostasis.
['Mochizuki-Kashio|Makiko|M|', 'Shiozaki|Hiroko|H|', 'Suda|Toshio|T|', 'Nakamura-Ishizu|Ayako|A|']
D000693:Anaerobiosis D000818:Animals D002454:Cell Differentiation D004970:Estrone D006019:Glycolysis D006412:Hematopoietic Stem Cells D006801:Humans D008247:Lysosomes D053142:Mitochondrial Size D063269:Mitochondrial Turnover D010085:Oxidative Phosphorylation D017382:Reactive Oxygen Species
mitochondria lysosome hematopoietic stem cells ROS autophagy folliculin