Nucleotides as nontoxic endogenous endosomolytic agents in drug delivery.
Nontoxic endogenous nucleotides such as adenosine triphosphate and guanosine triphosphate have secondary phosphate groups, causing proton-buffering capacity and/or hemolytic activity in endolysosomal pH ranges. Nucleotides co-delivered in single polymeric pDNA nanocarrier induce highly enhanced transfection efficiency with negligible cytotoxicity due to their endosomolytic functions.
['Cho|Hana|H|', 'Cho|Yong-Yeon|YY|', 'Bae|You Han|YH|', 'Kang|Han Chang|HC|']
D002470:Cell Survival D016503:Drug Delivery Systems D057809:HEK293 Cells D006367:HeLa Cells D006801:Humans D042541:Intracellular Space D049329:Nanostructures D009711:Nucleotides D014162:Transfection
nucleotide drug delivery ATP endosomolytic material gene delivery