Carboxytherapy for treatment of localized chronic plaque psoriasis: Clinical and histopathologic evaluation.
BACKGROUND
Multiple treatment options are introduced in treatment of chronic localized plaque psoriasis but with poor adherence and poor patients' satisfaction resulting in poor treatment outcome.


OBJECTIVE
In this pilot study, we investigated the safety and efficacy of carboxytherapy in treatment of chronic localized plaque psoriasis.


METHODS
Thirty adult patients with chronic localized plaque psoriasis were enrolled in this study. The patients received carboxytherapy injection once/week for 8 weeks. Patients were clinically and histpathologically evaluated 2 weeks after the last treatment. Clinical response was evaluated by investigator's global assessment, total sign score, and 5-point scale for perilesional erythema. We performed 10-point visual analog scale for patient's satisfaction, and side effects. Three months after the last session we evaluate recurrence using 10-point scale.


RESULTS
Carboxytherapy achieved treatment success in 26.6% according to investigator's global assessment and total sign score and 70% of the patients demonstrated absence of perilesional erythema. Patients were satisfied with no reported side effects. Recurrence area was within 1% -10% of the baseline area in 83.3% of the improved patients.
['Kamel|Abeer Mostafa|AM|', 'Abdelghani|Rania|R|http://orcid.org/0000-0002-1590-8375']
D000293:Adolescent D000328:Adult D000368:Aged D002245:Carbon Dioxide D002908:Chronic Disease D005260:Female D006801:Humans D007271:Injections, Intradermal D015552:Injections, Intralesional D008297:Male D008875:Middle Aged D017060:Patient Satisfaction D010865:Pilot Projects D011565:Psoriasis D012008:Recurrence D012720:Severity of Illness Index D016896:Treatment Outcome D055815:Young Adult
carboxytherapy localized plaque psoriasis