A Review of T-Cell Related Therapy for Osteosarcoma.
Osteosarcoma is one of the most common primary malignant tumors of bone. The combination of chemotherapy and surgery makes the prognosis better than before, but therapy has not dramatically improved over the last three decades. This is partially because of the lack of a novel specialized drug for osteosarcoma, which is known as a tumor with heterogeneity. On the other hand, immunotherapy has been one of the most widely used strategies for many cancers over the last ten years. The therapies related to T-cell response, such as immune checkpoint inhibitor and chimeric antigen receptor T-cell therapy, are well-known options for some cancers. In this review, we offer the accumulated knowledge of T-cell-related immunotherapy for osteosarcoma, and discuss the future of the therapy.
['Yoshida|Kazushige|K|', 'Okamoto|Masanori|M|0000-0003-0351-865X', 'Aoki|Kaoru|K|', 'Takahashi|Jun|J|', 'Saito|Naoto|N|']
D000818:Animals D001859:Bone Neoplasms D003131:Combined Modality Therapy D006801:Humans D007167:Immunotherapy D012516:Osteosarcoma D013601:T-Lymphocytes
T-cell osteosarcoma immunotherapy