Biomimetic nanotherapy: core-shell structured nanocomplexes based on the neutrophil membrane for targeted therapy of lymphoma.
BACKGROUND
Non-Hodgkin's lymphoma (NHL) is a malignant disease of lymphoid tissue. At present, chemotherapy is still the main method for the treatment of NHL. R-CHOP can significantly improve the survival rate of patients. Unfortunately, DOX is the main cytotoxic drug in R-CHOP and it can lead to adverse reactions. Therefore, it is particularly important to uncover new treatment options for NHL.


RESULTS
In this study, a novel anti-tumor nanoparticle complex Nm@MSNs-DOX/SM was designed and constructed in this study. Mesoporous silica nanoparticles (MSNs) loaded with Doxorubicin (DOX) and anti-inflammatory drugs Shanzhiside methylester (SM) were used as the core of nanoparticles. Neutrophil membrane (Nm) can be coated with multiple nanonuclei as a shell. DOX combined with SM can enhance the anti-tumor effect, and induce apoptosis of lymphoma cells and inhibit the expression of inflammatory factors related to tumorigenesis depending on the regulation of Bcl-2 family-mediated mitochondrial pathways, such as TNF-α and IL-1β. Consequently, the tumor microenvironment (TME) was reshaped, and the anti-tumor effect of DOX was amplified. Besides, Nm has good biocompatibility and can enhance the EPR effect of Nm@MSNs-DOX/SM and increase the effect of active targeting tumors.


CONCLUSIONS
This suggests that the Nm-modified drug delivery system Nm@MSNs-DOX/SM is a promising targeted chemotherapy and anti-inflammatory therapy nanocomplex, and may be employed as a specific and efficient anti-Lymphoma therapy.
['Zhao|Qiangqiang|Q|', 'Jiang|Duanfeng|D|', 'Sun|Xiaoying|X|', 'Mo|Qiuyu|Q|', 'Chen|Shaobin|S|', 'Chen|Wansong|W|', 'Gui|Rong|R|http://orcid.org/0000-0001-7790-0291', 'Ma|Xianjun|X|']
D000818:Animals D017209:Apoptosis D032701:Biomimetics D004195:Disease Models, Animal D004317:Doxorubicin D004337:Drug Carriers D016503:Drug Delivery Systems D006801:Humans D008223:Lymphoma D051379:Mice D008807:Mice, Inbred BALB C D008819:Mice, Nude D053758:Nanoparticles D009369:Neoplasms D009504:Neutrophils D010316:Particle Size D012822:Silicon Dioxide D059016:Tumor Microenvironment D023041:Xenograft Model Antitumor Assays
Neutrophil membrane Lymphoma Mesoporous silica nanoparticles Doxorubicin Shanzhiside methylester