Molecular mechanisms and genomic maps of DNA excision repair in Escherichia coli and humans.
Nucleotide excision repair is a major DNA repair mechanism in all cellular organisms. In this repair system, the DNA damage is removed by concerted dual incisions bracketing the damage and at a precise distance from the damage. Here, we review the basic mechanisms of excision repair in Escherichia coli and humans and the recent genome-wide mapping of DNA damage and repair in these organisms at single-nucleotide resolution.
['Hu|Jinchuan|J|', 'Selby|Christopher P|CP|', 'Adar|Sheera|S|', 'Adebali|Ogun|O|', 'Sancar|Aziz|A|']
D002874:Chromosome Mapping D004249:DNA Damage D004260:DNA Repair D004926:Escherichia coli D006801:Humans
carcinogenesis chemotherapy damage mapping damage recognition kinetic proofreading repair mapping