Clinical impact of lymphatic spread in patients with limited-stage upper aerodigestive tract NK/T cell lymphoma.
Background
We investigated whether distancemax, that is, the degree of distance between the upper aerodigestive tract (UAT) mass and the farthest pathologic lymph node, was significantly associated with survival in patients with limited-stage UAT natural killer/T cell lymphoma (NKTCL).


Methods
A total of 157 patients who received chemotherapy (CTx) with/without radiotherapy (RTx) were enrolled.


Results
In the survival analysis, an elevated lactate dehydrogenase level [progression-free survival (PFS): hazard ratio (HR), 2.948; 95% confidence interval (CI), 1.606‒5.404; P <0.001; overall survival (OS): HR, 2.619; 95% CI, 1.594‒4.822; P =0.003], short distancemax (PFS: HR, 0.170; 95% CI, 0.071‒0.410; P <0.001; OS: HR, 0.142; 95% CI, 0.050‒0.402; P < 0.001), and CTx combined with RTx (HR, 0.168; 95%CI, 0.079‒0.380; P <0.001; OS: HR, 0.193; 95% CI, 0.087‒0.429; P <0.001) had an independent predictive value for PFS and OS.


Conclusion
The evaluation of the degree of lymphatic spread and local control by CTx combined with RTx is essential in patients with limited-stage UAT NKTCL.
['Song|Moo-Kon|MK|', 'Chung|Joo-Seop|JS|', 'Oh|Sung-Yong|SY|', 'Lim|Sung-Nam|SN|', 'Lee|Won-Sik|WS|', 'Lee|Sang-Min|SM|', 'Kim|Do-Young|DY|']
Upper aerodigestive tract Natural killer/T cell lymphoma Radiotherapy