Symptoms of Depression and Anxiety Are Independently Associated With Clinical Recurrence of Inflammatory Bowel Disease.
BACKGROUND & AIMS
We examined the relationship between symptoms of depression and anxiety and clinical recurrence of inflammatory bowel disease (IBD) in a large patient cohort. We considered the progression of depression and anxiety over time.


METHODS
We collected clinical and treatment data on 2007 adult participants of the Swiss IBD study (56% with Crohn's disease [CD], 48% male) performed in Switzerland from 2006 through 2015. Depression and anxiety symptoms were quantified by using the Hospital Anxiety and Depression Scale. The relationship between depression and anxiety scores and clinical recurrence was analyzed by using survival-time techniques.


RESULTS
We found a significant association between symptoms of depression and clinical recurrence over time (for all patients with IBD, P = .000001; for subjects with CD, P = .0007; for subjects with ulcerative colitis, P = .005). There was also a significant relationship between symptoms of anxiety and clinical recurrence over time in all subjects with IBD (P = .0014) and in subjects with CD (P = .031) but not ulcerative colitis (P = .066).


CONCLUSIONS
In an analysis of a large cohort of subjects with IBD, we found a significant association between symptoms of depression or anxiety and clinical recurrence. Patients with IBD should therefore be screened for clinically relevant levels of depression and anxiety and referred to psychologists or psychiatrists for further evaluation and treatment.
['Mikocka-Walus|Antonina|A|', 'Pittet|Valerie|V|', 'Rossel|Jean-Benoît|JB|', 'von Känel|Roland|R|', '|||']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D001007:Anxiety D003863:Depression D005260:Female D006801:Humans D015212:Inflammatory Bowel Diseases D008297:Male D008875:Middle Aged D011446:Prospective Studies D012008:Recurrence D012720:Severity of Illness Index D013557:Switzerland D055815:Young Adult
CD HADS Mental Health UC