Clopidogrel resistance: the way forward.
Clopidogrel, a second generation thienopyridine has been the mainstay of ACS (Acute Coronary Syndrome) treatment for more than a decade. Clopidogrel Resistance has been associated with increased mortality in ACS patients with an increase in number of Stent Thrombosis. This review article tries to find out the causes of Clopidogrel Resistance, the main factors involving it, Laboratory evaluation of Clopidogrel Resistance. The overall incidence of Clopidogrel Resistance across the Globe & India has also been considered. The article also discusses the clinical significance of Clopidogrel Resistance & its relationship with adverse cardiovascular events. This review ends with the probable solutions to Clopidogrel Resistance & the new generation of antiplatelets which can be used for the same.
['Ray|Shuvanan|S|']
D054058:Acute Coronary Syndrome D000077144:Clopidogrel D004351:Drug Resistance D006801:Humans D010975:Platelet Aggregation Inhibitors D013988:Ticlopidine
Clopidogrel resistance Stent thrombosis Platelet reactivity Prasugrel Ticagrelor