EML4-ALK fusion gene in Korean non-small cell lung cancer.
A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated EML4-ALK fusion genes in Korean NSCLCs, the prevalence of different EML4-ALK fusion variants has yet to be clearly assessed. Herein, we have examined the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLCs. EML4-ALK fusion genes have been detected in 10 (6.0%) of 167 patients of NSCLCs and in 9 (7.4%) of 121 patients of adenocarcinoma. Of the 10 patients with fusion genes identified, 8 (80%) were E13;A20 (variant 1) and 2 (20%) were E6;A20, with an additional 33-bp sequence derived from intron 6 of EML4 (variant 3b). These results indicate that the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLC may differ from those in other ethnic populations. Herein, we describe for the first time the profiles of EML4-ALK fusion variants of Korean patients with NSCLCs.
['Jin|Guang|G|', 'Jeon|Hyo-Sung|HS|', 'Lee|Eung Bae|EB|', 'Kang|Hyo-Gyoung|HG|', 'Yoo|Seung Soo|SS|', 'Lee|Shin Yup|SY|', 'Lee|Jae Hee|JH|', 'Cha|Sung Ick|SI|', 'Park|Tae In|TI|', 'Kim|Chang Ho|CH|', 'Jheon|Sang Hoon|SH|', 'Park|Jae Yong|JY|']
D000230:Adenocarcinoma D000368:Aged D044466:Asians D001483:Base Sequence D002289:Carcinoma, Non-Small-Cell Lung D005091:Exons D005260:Female D006801:Humans D007438:Introns D008175:Lung Neoplasms D008297:Male D008875:Middle Aged D015514:Oncogene Proteins, Fusion D056910:Republic of Korea D017423:Sequence Analysis, RNA D012907:Smoking
EML4 ALK Carcinoma Non-Small-Cell Lung