Impact of chronic lung allograft dysfunction, especially restrictive allograft syndrome, on the survival after living-donor lobar lung transplantation compared with cadaveric lung transplantation in adults: a single-center experience.
PURPOSE
The differences in chronic lung allograft dysfunction (CLAD) between living-donor lobar lung transplantation (LDLLT) and cadaveric lung transplantation (CLT) remain unclear. We conducted this study to compare the impact of CLAD on the outcomes after LDLLT vs. CLT.


METHODS
We conducted a retrospective review of the data of 97 recipients of bilateral lung transplantation, including 51 recipients of LDLLT and 46 recipients of CLT.


RESULTS
The CLAD-free survival and overall survival after LDLLT were similar to those after CLT. CLAD and restrictive allograft syndrome (RAS), but not bronchiolitis obliterans syndrome (BOS), developed significantly later after LDLLT than after CLT (p = 0.015 and p = 0.035). Consequently, patients with CLAD and RAS, but not those with BOS, after LDLLT had a significantly better overall survival than those after CLT (p = 0.037 and p = 0.0006). Furthermore, after the diagnosis of CLAD, the survival of patients with RAS after LDLLT tended to be better than that after CLT (p = 0.083).


CONCLUSION
CLAD, especially RAS, appears to develop later after LDLLT than after CLT and seems to have a lower impact on the overall survival after LDLLT than that after CLT.
['Sugimoto|Seiichiro|S|', 'Yamamoto|Haruchika|H|', 'Kurosaki|Takeshi|T|', 'Otani|Shinji|S|', 'Okazaki|Mikio|M|', 'Yamane|Masaomi|M|', 'Toyooka|Shinichi|S|', 'Oto|Takahiro|T|']
D000328:Adult D064591:Allografts D002102:Cadaver D002908:Chronic Disease D006801:Humans D019520:Living Donors D016040:Lung Transplantation D055031:Primary Graft Dysfunction D015996:Survival Rate D013577:Syndrome D013997:Time Factors
Chronic lung allograft dysfunction Restrictive allograft syndrome Living-donor Lung transplantation Bronchiolitis obliterans syndrome Rejection