Repeated "all out" interval exercise causes an increase in serum hepcidin concentration in both trained and untrained men.
This investigation assessed effects of high-intensity interval exercise (HIE; triple Wingate anaerobic test) on inflammatory markers, iron metabolism and hepcidin concentrations. Group of highly trained judo athletes (TR) and non-trained control males (CG) completed a triple Wingate test separated by 4.5min rest. Venous blood samples were collected before, immediately after, 1h, 24h, and 5days following exercise and analysed for serum of IL-6, IL-10, iron, and ferritin. Physiological response to exercise was also determined. Concentration of IL-6 and hepcidin increased 1h after exercise in both groups (p<0.05). Hepcidin returned post testing 24h in TR, whereas in CG it remained elevated during 5days following exercise. Changes in hepcidin did not correlate with shifts in serum IL-6, iron and ferritin concentrations. Gathered data suggest that following HIE, hepcidin increased independently of IL-6 and neither blood nor storage iron affected this phenomena.
['Antosiewicz|Jędrzej|J|', 'Kaczor|Jan J|JJ|', 'Kasprowicz|Katarzyna|K|', 'Laskowski|Radosław|R|', 'Kujach|Sylwester|S|', 'Luszczyk|Marcin|M|', 'Radziminski|Lukasz|L|', 'Ziemann|Ewa|E|']
D023181:Antimicrobial Cationic Peptides D056352:Athletes D004797:Enzyme-Linked Immunosorbent Assay D015444:Exercise D064451:Hepcidins D006801:Humans D015850:Interleukin-6 D008297:Male D010807:Physical Endurance D055815:Young Adult
Iron Triple Wingate test Cytokines