Differential Markers of Bacterial and Viral Infections in Children for Point-of-Care Testing.
Children suffering from infectious diseases, both bacterial and viral, are often treated with empirical antibiotics. Keeping in mind both the menace of microorganisms and antibiotic toxicity, it is imperative to develop point-of-care testing (POCT) to discriminate bacterial from viral infections, and to define indications for antibiotic treatment. This article reviews potential protein biomarkers and host-derived gene expression signatures for differentiating between bacterial and viral infections in children, and focuses on emerging multiplex POCT devices for the simultaneous detection of sets of protein biomarkers or streamlined gene expression signatures that may provide rapid and cost-effective pathogen-discriminating tools.
['Tsao|Yu-Ting|YT|', 'Tsai|Yao-Hung|YH|', 'Liao|Wan-Ting|WT|', 'Shen|Ching-Ju|CJ|', 'Shen|Ching-Fen|CF|', 'Cheng|Chao-Min|CM|']
D000367:Age Factors D001424:Bacterial Infections D015415:Biomarkers D002648:Child D003937:Diagnosis, Differential D003955:Diagnostic Tests, Routine D054884:Host-Pathogen Interactions D006801:Humans D000067716:Point-of-Care Testing D014777:Virus Diseases
viral infection point-of-care testing (POCT) biomarkers multiplex bacterial infection host transcriptional signature