Hybrid Wireframe DNA Nanostructures with Scaffolded and Scaffold-Free Modules.
The scaffolded DNA origami approach and the scaffold-free LEGO approach both demonstrate an extraordinary self-assembly capability for constructing all kinds of complex DNA nanostructures. Combining the construction elements of the two approaches, we introduce a hybrid framework to build wireframe structures in this study. A collection of two-dimensional (2D) and three-dimensional (3D) wireframe structures are presented to showcase the simple and versatile design. Our development reveals more of the ever-expanding design space of structural DNA nanotechnology.
['Cui|Yan|Y|', 'Yan|Jun|J|', 'Wei|Bryan|B|0000-0003-2857-9352']
wireframe DNA origami self-assembly hybrid frameworks