Pediatric patients with orofacial granulomatosis likely to subsequently develop intestinal Crohn's disease: Brief Report.
Orofacial granulomatosis (OFG) is an uncommon chronic granulomatous condition presenting as perioral inflammation in the absence of systemic disease. There is continued debate regarding whether OFG is a distinct clinical disorder or a manifestation of orofacial Crohn's disease. Our retrospective review identified 7 patients diagnosed with OFG between 2000 and 2018 at a tertiary pediatric hospital. Four of the 7 patients subsequently developed Crohn's disease with a median delay of 3.1 years (range 0.4-6.9 years). This indicates that gastroenterology evaluation with long-term monitoring for intestinal Crohn's disease is warranted.
['Chen|Kristen L|KL|https://orcid.org/0000-0002-0361-9234', 'Diiorio|Daren A|DA|', 'Chiu|Yvonne E|YE|https://orcid.org/0000-0003-2869-2718', 'Sokumbi|Olayemi|O|']
D002648:Child D003424:Crohn Disease D051261:Granulomatosis, Orofacial D006801:Humans D007249:Inflammation D012189:Retrospective Studies D062606:Tertiary Care Centers
pediatrics orofacial granulomatosis Crohn's disease