Biological role and clinical implications of homeobox genes in serous epithelial ovarian cancer.
Homeobox (HOX) genes are a family of transcription factors that are essential regulators of development. HOX genes play important roles in normal reproductive physiology, as well as in the development and progression of serous carcinomas, the predominant and most aggressive subtype of epithelial ovarian cancer (EOC). This review discusses aberrant HOX gene expression in serous EOC and its impact on tumor development and progression. Further identification of HOX target genes may facilitate the development of novel diagnostic and therapeutic strategies to improve the prognosis of patients with serous EOC.
['Miller|Katherine R|KR|', 'Patel|Jai N|JN|', 'Ganapathi|Mahrukh K|MK|', 'Tait|David L|DL|', 'Ganapathi|Ram N|RN|']
D000818:Animals D000077216:Carcinoma, Ovarian Epithelial D005260:Female D015972:Gene Expression Regulation, Neoplastic D005801:Genes, Homeobox D006801:Humans D009375:Neoplasms, Glandular and Epithelial D010051:Ovarian Neoplasms
Gene Serous Ovarian Cancer HOX Protein