Emergence of new genotype and diversity of Theileria orientalis parasites from bovines in India.
Bovine theileriosis is a serious threat to livestock worldwide. Uncertainty around species prevalence, antigenic diversity and genotypes of strains make it difficult to assess the impact of this parasite and to provide necessary treatment. We aimed to characterize genotypic diversity, phylogeny and prevalence of Theileria orientalis parasites from the states of Telangana and Andhra Pradesh, India by collecting bovine blood samples from the major districts of the two states. Bioinformatic analysis identified antigenic diversity among the prevalent parasite strains using major piroplasm surface protein (MPSP) gene. Our study revealed a prevalence rate of 4.8% (n=41/862) of T. orientalis parasites in bovine animals and a new genotype of T. orientalis parasite which was not previously reported in India. The emergence of these new genotypes could be an explanation for the frequent outbreaks of bovine theileriosis. Further, whole genome sequencing of T. orientalis strains will help to elucidate the genetic factors relevant for transmissibility and virulence as well as vaccine and new drug development.
['George|Neena|N|', 'Bhandari|Vasundhra|V|', 'Reddy|D Peddi|DP|', 'Sharma|Paresh|P|']
D000818:Animals D000953:Antigens, Protozoan D001483:Base Sequence D002417:Cattle D002418:Cattle Diseases D014644:Genetic Variation D005838:Genotype D062306:Geography, Medical D007194:India D008969:Molecular Sequence Data D010802:Phylogeny D058974:Phylogeography D015995:Prevalence D015800:Protozoan Proteins D016415:Sequence Alignment D016794:Theileria D013801:Theileriasis
Theileriosis Antigenic diversity Phylogeny Major piroplasm surface protein