Effects of Cuminum cyminum L. essential oil on some epididymal sperm parameters and histopathology of testes following experimentally induced copper poisoning in mice.
Copper overload can cause sperm cell damage by inducing oxidative stress. On the other hand, cumin has a good antioxidant potential. Therefore, the aim of this study was to evaluate the effects of cumin on sperm quality and testicular tissue following experimentally induced copper poisoning in mice. Forty-eight mature male mice were divided into four equal groups as follows: group Cu which received 0.1 ml copper sulphate at dose of 100 mg kg(-1) , group Cc which received Cuminum cyminum at dose of 1 mg kg(-1) , treatment group which received copper sulphate (100 mg kg(-1) ) and treated with Cuminum cyminum (1 mg kg(-1) ), and control group which received the same volume of normal saline. Six mice in each group were sacrificed at week 4 and week 6. The results showed that sperm concentration, motility and viability in group Cu were significantly decreased at weeks 4 and 6, and severe degenerative changes were observed in testicular tissues in comparison with the control group. In treatment group, significant improvement in the sperm count, motility and viability, and normal architecture in most seminiferous tubules with organised epithelium was observed compared to the group Cu. The sperm quality parameters in the treatment group approached those of the control group.
['Sakhaee|E|E|', 'Emadi|L|L|', 'Azari|O|O|', 'Kheirandish|R|R|', 'Esmaili Nejad|M R|MR|', 'Shafiei Bafti|H|H|']
D000818:Animals D000975:Antioxidants D003300:Copper D028527:Cuminum D004822:Epididymis D008297:Male D051379:Mice D009822:Oils, Volatile D055101:Semen Analysis D013094:Spermatozoa D013737:Testis
Cuminum cyminum testes mice sperm quality Copper toxicosis