Discovery of a 1,2-bis(3-indolyl)ethane that selectively inhibits the pyruvate kinase of methicillin-resistant Staphylococcus aureus over human isoforms.
Methicillin-resistant Staphylococcus aureus pyruvate kinase (MRSA PK) has recently been identified as a target for development of novel antibacterial agents. Testing a series of 1,2-bis(3-indolyl)ethanes against MRSA PK has led to the discovery of a potent inhibitor that is selective over human isoforms.
['Zoraghi|Roya|R|', 'Campbell|Sara|S|', 'Kim|Catrina|C|', 'Dullaghan|Edie M|EM|', 'Blair|Lachlan M|LM|', 'Gillard|Rachel M|RM|', 'Reiner|Neil E|NE|', 'Sperry|Jonathan|J|']
D000900:Anti-Bacterial Agents D004353:Drug Evaluation, Preclinical D004791:Enzyme Inhibitors D004980:Ethane D006801:Humans D007211:Indoles D055624:Methicillin-Resistant Staphylococcus aureus D011485:Protein Binding D020033:Protein Isoforms D011770:Pyruvate Kinase
Pyruvate kinase MRSA Antibacterial Indole