Hypolipidaemic and anti-lipidperoxidant activities of Ganoderma lucidum polysaccharide.
Ganoderma lucidum polysaccharide (GLP) was prepared by hot water extraction and partly characterised by high-performance gel filtration chromatography and its monosaccharide composition. Male Sprague-Dawley rats were randomly divided into four groups: one group received a high-fat diet (control group) and the three other groups received a high-fat diet containing 100, 300 and 500 mg/kg of GLP. GLP administration reduced the body weight gain, food efficiency ratio, levels of plasma triacylglycerol (TG), plasma total cholesterol (TC) and low-density lipoprotein cholesterol and liver weight, TC and TG levels and malondialdehyde values, improved the levels of faecal fat, cholesterol and plasma high-density lipoprotein cholesterol and enhanced the activities of serum superoxide dismutase and glutathione peroxidase in rats compared with the control group. The appropriate dose of GLP was 300 mg/kg. Results indicate that GLP exhibits hypolipidaemic and lipid antioxidant activities and may be used as a drug for hyperlipidaemia treatment.
['Wu|Shengjun|S|']
D000818:Animals D001835:Body Weight D002784:Cholesterol D004435:Eating D005243:Feces D062610:Fungal Polysaccharides D005979:Glutathione Peroxidase D000960:Hypolipidemic Agents D015227:Lipid Peroxidation D008099:Liver D008297:Male D008315:Malondialdehyde D009929:Organ Size D020072:Polyporales D051381:Rats D017207:Rats, Sprague-Dawley D013482:Superoxide Dismutase
Hypolipidaemic Ganoderma lucidum Polysaccharide