Diagnostic performance of using effervescent powder for detection and grading of esophageal varices by multi-detector computed tomography.
PURPOSE
To investigate the effect of using effervescent powder (EP) on the efficacy of multi-detector computed tomography (MDCT) in detection and grading of esophageal varices in cirrhotic patients by considering endoscopy as the gold standard.


MATERIALS AND METHODS
Ninety-two cirrhotic patients undergoing biphasic liver MDCT followed by upper gastrointestinal endoscopy within 4 weeks of MDCT were prospectively evaluated. The patients were divided into two groups before MDCT. The first group (n=50) received effervescent powder (EP) before and during MDCT procedure and the second group did not receive (n=42). The presence, size and grade of the esophageal varices were evaluated. MDCT findings were compared with endoscopic results. The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of MDCT with EP and without EP were calculated and compared. Correlations between the grades of the varices for each group based on MDCT imaging and endoscopic grading were also evaluated.


RESULTS
The sensitivity, specificity, accuracy, PPV, and NPV of MDCT were 100%, 88%, 96%, 94%, and 100%, respectively, in the EP group, whereas they were 76%, 67%, 74%, 89%, and 43%, respectively, in the non-EP group. Correlations between the grades of the esophageal varices on MDCT and endoscopy were significant in both groups (r=0.94, p<0.001 for EP group and r=0.70, p<0.001 for non-EP group).


CONCLUSION
During periodic CT scanning of cirrhotic patients, use of EP increases the success rate of MDCT for detection and grading of esophageal varices.
['Cansu|Aysegul|A|', 'Ahmetoglu|Ali|A|', 'Kul|Sibel|S|', 'Yukunc|Gokcen|G|', 'Fidan|Sami|S|', 'Arslan|Mehmet|M|', 'Topbas|Murat|M|']
D000284:Administration, Oral D003287:Contrast Media D004932:Esophageal and Gastric Varices D005260:Female D006801:Humans D007089:Image Enhancement D008103:Liver Cirrhosis D008297:Male D008875:Middle Aged D061330:Multidetector Computed Tomography D015203:Reproducibility of Results D012680:Sensitivity and Specificity D017693:Sodium Bicarbonate D013644:Tartrates
Effervescent powder Esophageal varices Computed tomography Cirrhosis