Types of human papillomavirus observed in hospital-based population.
Background and Objectives
Human papillomavirus (HPV) is the causative agent of cervical cancer, a major cause of cancer mortality in Indian women. The current study was undertaken to add information to the existing data on HPV type distribution in Indians, in an attempt to document HPV types for future vaccination programme, if any.


Materials and Methods
HPV infection was screened in 223 cervical cancer cases and 2408 healthy women without cancer and cervical intraepithelial neoplasia (control). HPV was typed using polymerase chain reaction, Southern hybridisation using specific probes and HPV GenoArray (Hybribio) test.


Results
HPV DNA was found in 92.8% of cases and 7.3% of controls. Of the 383 HPV-infected women, 30.0% had single infection; 50.9% had multiple infections (two or more types) and 19.1% were infected with HPV types other than HPV-16, -18, -6 and -11. Besides HPV-16, HPV-51 and HPV-33 were also seen as single infection in cases. In cases, HPV-18 or its homologous HPV-45 was always present as co-infection with HPV-16 or with other high-risk type. Binary logistic regression (backward) analysis highlighted significant association of age, parity and socioeconomic status with HPV infection. The present study highlighted the presence of multiple HPV infection (186 of 207, 89.9%) along with HPV-16 in women with cervical cancer. In control, 27.3% were co-infected with other sexually transmitted infections, while Chlamydia trachomatis infection was seen in 13% of cases.


Conclusions
The study highlighted the type of HPV infection seen among the hospital-based population. For better screening, HPV tests available in the market should include all the types seen in the population.
['Wagh|Priyanka|P|', 'Kulkarni|Priyanka|P|', 'Kerkar|Shilpa|S|', 'Tongaonkar|Hemant|H|', 'Deodhar|Kedar|K|', 'Rekhi|Bharat|B|', 'Salvi|Vinita|V|', 'Chaudhari|Hemangi|H|', 'Warke|Himangi|H|', 'Mania-Pramanik|Jayanti|J|']
D000328:Adult D018290:Cervical Intraepithelial Neoplasia D002690:Chlamydia Infections D002692:Chlamydia trachomatis D004279:DNA, Viral D005260:Female D006761:Hospitals D006801:Humans D027383:Papillomaviridae D030361:Papillomavirus Infections D012749:Sexually Transmitted Diseases D002583:Uterine Cervical Neoplasms
human papillomavirus Cervical cancer Indian populations