Parosteal osteosarcoma with a manifestation of subperiosteal low-grade central osteosarcoma.
We report the peculiar case of a parosteal osteosarcoma arising beneath the periosteum in a 12-year-old boy. He complained of difficulty in left knee flexion. Plain radiography showed a uniformly dense mineralized mass in the bone cortex and parosteal ossified nodules at the metaphysis and diaphysis of the left distal femur. Periosteal reaction was not evident. Uniquely, plain radiography had a smooth outline and revealed gradually thickening mass toward the center. Histologically, the tumor showed a proliferation of spindle-shaped cells with parallel-oriented dense bone trabeculae and hyaline cartilaginous tissue disclosing mild atypia. The periosteum was inverted along the polypoid mass, but there was no periosteum at the top. Immunohistochemically, the spindle cells, including those at the top of the polypoid mass, and cartilaginous cells were positive for MDM2 and CDK4. MDM2 gene amplification was detected in these cells by fluorescence in situ hybridization. Despite the peculiar feature of plain radiography, the lesion was diagnosed as parosteal osteosarcoma. This case report presents a case of parosteal osteosarcoma arising beneath the periosteum, although it is postulated to arise in the outer layer of the periosteum. The unique radiographic findings in this case suggest an association of parosteal osteosarcoma with vigorous bone growth before closure of the growth plate.
['Ishihara|Shin|S|', 'Kohashi|Kenichi|K|', 'Kuboyama|Yusuke|Y|', 'Nakashima|Yasuharu|Y|', 'Oda|Yoshinao|Y|']
D001859:Bone Neoplasms D002648:Child D006801:Humans D017404:In Situ Hybridization, Fluorescence D008297:Male D012516:Osteosarcoma D010521:Periosteum D011859:Radiography
Parosteal osteosarcoma MDM2