Testing for Hereditary Predisposition in Patients with Gynecologic Cancers, Quo Vadis?
Genetic testing for a hereditary predisposition to gynecologic cancers has been available clinically since the 1990s. Since then, knowledge of the hereditary contribution to gynecologic cancers has dramatically increased, especially with respect to ovarian cancer. Although knowledge of the number of gynecologic cancer-predisposing genes has increased, the integration of genetic predisposition testing into routine clinical practice has been much slower. This article summarizes the technical and practical aspects of genetic testing in gynecologic cancers, the potential barriers to more widespread access and practice of genetic testing for hereditary predisposition to gynecologic cancers, and the potential solutions to these barriers.
['Mitchell|Gillian|G|', 'Schrader|Kasmintan A|KA|']
D056733:Carney Complex D003937:Diagnosis, Differential D004687:Enchondromatosis D005260:Female D020022:Genetic Predisposition to Disease D005820:Genetic Testing D005833:Genital Neoplasms, Female D006223:Hamartoma Syndrome, Multiple D006801:Humans D018231:Leiomyomatosis D018192:Lymphangioleiomyomatosis D009386:Neoplastic Syndromes, Hereditary D054973:Perivascular Epithelioid Cell Neoplasms D011379:Prognosis D012878:Skin Neoplasms D014402:Tuberous Sclerosis D014594:Uterine Neoplasms
Gynecologic cancer Genetic predisposition Gene panels Multiplex genetic testing