Determination of enantioselectivity and enantiomeric excess by mass spectrometry in the absence of chiral chromatographic separation: an overview.
This review describes the principles and instrumentation for the screening of asymmetric reactions by mass spectrometry. These techniques witnessed a significant advancement in the last few years. Although some of them are still at the proof-of-concept development stage, several applications might be foreseen in the field of combinatorial, high-throughput parallel catalyst screening.
['Piovesana|Susy|S|', 'Samperi|Roberto|R|', 'Laganà|Aldo|A|', 'Bella|Marco|M|']
enantioselectivity enantiomeric excess mass spectrometry analytical chemistry