Treatment and outcomes for patients with depression who are partial responders to SSRI treatment: post-hoc analysis findings from the FINDER European observational study.
BACKGROUND
Remission is the goal in depression, but in practice many patients only experience a partial response to treatment. We sought to determine the prevalence, management and subsequent outcomes of partial responder patients.


METHODS
Patients enrolled in the naturalistic Factors Influencing Depression Endpoints Research (FINDER) study with the Hospital Anxiety and Depression Scale depression subscale (HADS-D) score >10 at baseline who received only SSRI(s) between 0 and 3 months comprised the study cohort (n=1147). Patients were categorized as remitters, partial responders or non-responders at 3 months and then followed up at 6 months.


RESULTS
At 3 months, 29.4% of the study population were considered non-responders, 27.6% were partial responders, and 39.3% were remitters. Most partial responders at 3 months remained on the same SSRI for the next 3 months. Of the 247 partial responders at 3 months and remained on the same SSRI(s) between 3 and 6 months, 10.9% met criteria for non-response at 6 months, 32.4% remained partial responders, and 56.3% achieved remission. Quality of life outcomes for the partial responders were significantly worse than those in remission (p<0.05).


LIMITATIONS
FINDER was an observational study; the current analysis was conducted post-hoc. Multivariable methods were not applied and findings are primarily descriptive and exploratory.


CONCLUSIONS
Partial response is common and patients in partial response have a poorer quality of life than those achieving remission. Despite this, the majority of partial responders continue to take the same SSRI. Our findings underscore the importance of continuing to strive for remission.
['Lenox-Smith|A|A|', 'Martinez|J M|JM|', 'Perahia|D|D|', 'Dowsett|S A|SA|', 'Dennehy|E B|EB|', 'Lopez-Romero|P|P|', 'Demyttenaere|K|K|']
D000328:Adult D018687:Antidepressive Agents, Second-Generation D015331:Cohort Studies D003863:Depression D003866:Depressive Disorder D005060:Europe D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D011788:Quality of Life D017367:Serotonin Uptake Inhibitors D016896:Treatment Outcome
Depression Observational study Remission Partial response