Dynamic thiol/disulphide homeostasis in patients with newly diagnosed primary hypertension.
We aimed to investigate the thiol/disulphide homeostasis in patients with newly diagnosed primary hypertension with a novel and automated method. Blood thiol/disulphide homeostasis, which consists of native thiol/disulphide exchanges, was investigated in 45 patients with primary hypertension and 45 healthy controls. The levels of native thiol, total thiol, and native thiol/total thiol ratio were lower while the disulphide level and disulphide/native thiol and disulphide/total thiol ratios were higher in patients with primary hypertension when compared with those in the control group. Positive correlation was detected between 24-hour systolic and diastolic blood pressure levels and disulphide/native thiol ratio. With reference to the stepwise multiple linear regression model; increase in disulphide/native thiol ratio and log(24-hour urine microalbumin) and decrease in native thiol/total thiol ratio are independent predictors of 24-hour systolic and diastolic blood pressure. This study demonstrated that thiol/disulphide homeostasis was shifted toward disulphide formation in patients with primary hypertension.
['Ates|Ihsan|I|', 'Ozkayar|Nihal|N|', 'Inan|Bayram|B|', 'Yilmaz|Fatma Meric|FM|', 'Topcuoglu|Canan|C|', 'Neselioglu|Salim|S|', 'Erel|Ozcan|O|', 'Dede|Fatih|F|', 'Yilmaz|Nisbet|N|']
D000328:Adult D000975:Antioxidants D001794:Blood Pressure D018660:Blood Pressure Monitoring, Ambulatory D002623:Chemistry Techniques, Analytical D004220:Disulfides D000075222:Essential Hypertension D005260:Female D006706:Homeostasis D006801:Humans D006973:Hypertension D016014:Linear Models D008297:Male D008875:Middle Aged D018384:Oxidative Stress D013438:Sulfhydryl Compounds D014421:Turkey
Blood pressure oxidative stress oxidized thiol sulfur bonds