Increased blood flow and vasculature in solar lentigo.
Solar lentigo (SL) is a hallmark of ultraviolet (UV)-induced photoaged skin and growing evidence implicates blood vessels in UV-associated pigmentation. In this study, we investigated whether the vasculatures are modified in SL. Twenty-five women with facial SL were enrolled and colorimetric and blood flow studies were performed. There was a significant increase in erythema which was associated with increased blood flow in the lesional skin compared with perilesional normal skin. Immunohistochemical studies with 24 facial SL biopsies consistently revealed a significant increase in vessel density accompanied by increased levels of vascular endothelial growth factor expression. CD68 immunoreactivity was significantly higher in lesional skin suggesting increased macrophage infiltration in SL. In conclusion, SL is characterized by increased blood flow and vasculature. These findings suggest the possible influence of the characteristics of vasculature on development of SL.
['Hasegawa|Kiyotaka|K|', 'Fujiwara|Rumiko|R|', 'Sato|Kiyoshi|K|', 'Park|Ji-Youn|JY|', 'Kim|Sang Jin|SJ|', 'Kim|Misun|M|', 'Kang|Hee Young|HY|']
D000328:Adult D015703:Antigens, CD D015214:Antigens, Differentiation, Myelomonocytic D001706:Biopsy D001783:Blood Flow Velocity D003124:Colorimetry D020405:Dermis D004890:Erythema D005145:Face D005260:Female D006801:Humans D007150:Immunohistochemistry D007911:Lentigo D008875:Middle Aged D012189:Retrospective Studies D015595:Skin Aging D014466:Ultraviolet Rays D042461:Vascular Endothelial Growth Factor A
lentigo blood vessel vascular endothelial growth factor macrophage hyperpigmentation