Improvement of chemosensitivity and inhibition of migration via targeting tumor epithelial-to-mesenchymal transition cells by ADH-1-modified liposomes.
How to overcome drug resistance and prevent tumor metastasis is key to the success of malignant tumor therapy. In this paper, ADH-1 peptide-modified liposomes (A-LP) have been successfully constructed for restoring chemosensitivity and suppressing cancer cell migration. With a particle size of about 90 nm, this functionalized nanocarrier was loaded with fluorescent probe or paclitaxel (PTX). Cellular uptake studies showed that A-LP facilitated the delivery of anticancer drug to tumor cells undergoing EMT. Interestingly, this nanocarrier enhanced chemosensitivity by assessing the cell activity using CCK-8 assay. Further, the results of Wound scratch assay and Transwell migration assay showed the inhibition effect of this nanocarrier on tumor cell migration. Moreover, this nanocarrier exhibited significant tumor-targeting ability and anti-tumor efficacy in vivo. Collectively, A-LP might be a novel targeted drug delivery system to enhance the efficacy of chemotherapy and prevent tumor metastasis.
['Guo|Zhaoming|Z|', 'Li|Wenqing|W|', 'Yuan|Yue|Y|', 'Zheng|Kun|K|', 'Tang|Yu|Y|', 'Ma|Kun|K|', 'Cui|Changhao|C|', 'Wang|Li|L|', 'He|Bing|B|', 'Zhang|Qiang|Q|']
D000818:Animals D000970:Antineoplastic Agents D045744:Cell Line, Tumor D002465:Cell Movement D004337:Drug Carriers D016503:Drug Delivery Systems D058750:Epithelial-Mesenchymal Transition D005260:Female D006801:Humans D008081:Liposomes D061986:MCF-7 Cells D051379:Mice D008807:Mice, Inbred BALB C D008819:Mice, Nude D053758:Nanoparticles D009842:Oligopeptides D017239:Paclitaxel D010316:Particle Size D010456:Peptides, Cyclic
migration targeting liposomes delivery Chemoresistance