Reproducibility Between Brain Uptake Ratio Using Anatomic Standardization and Patlak-Plot Methods.
UNLABELLED
The Patlak-plot and conventional methods of determining brain uptake ratio (BUR) have some problems with reproducibility. We formulated a method of determining BUR using anatomic standardization (BUR-AS) in a statistical parametric mapping algorithm to improve reproducibility. The objective of this study was to demonstrate the inter- and intraoperator reproducibility of mean cerebral blood flow as determined using BUR-AS in comparison to the conventional-BUR (BUR-C) and Patlak-plot methods.


METHODS
The images of 30 patients who underwent brain perfusion SPECT were retrospectively used in this study. The images were reconstructed using ordered-subset expectation maximization and processed using an automatic quantitative analysis for cerebral blood flow of ECD tool. The mean SPECT count was calculated from axial basal ganglia slices of the normal side (slices 31-40) drawn using a 3-dimensional stereotactic region-of-interest template after anatomic standardization. The mean cerebral blood flow was calculated from the mean SPECT count. Reproducibility was evaluated using coefficient of variation and Bland-Altman plotting.


RESULTS
For both inter- and intraoperator reproducibility, the BUR-AS method had the lowest coefficient of variation and smallest error range about the Bland-Altman plot. Mean CBF obtained using the BUR-AS method had the highest reproducibility.


CONCLUSION
Compared with the Patlak-plot and BUR-C methods, the BUR-AS method provides greater inter- and intraoperator reproducibility of cerebral blood flow measurement.
['Shibutani|Takayuki|T|', 'Onoguchi|Masahisa|M|', 'Noguchi|Atsushi|A|', 'Yamada|Tomoki|T|', 'Tsuchihashi|Hiroko|H|', 'Nakajima|Tadashi|T|', 'Kinuya|Seigo|S|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D001692:Biological Transport D001921:Brain D002560:Cerebrovascular Circulation D005260:Female D006801:Humans D007091:Image Processing, Computer-Assisted D008297:Male D008875:Middle Aged D015588:Observer Variation D012015:Reference Standards D015203:Reproducibility of Results D012189:Retrospective Studies D015899:Tomography, Emission-Computed, Single-Photon
reproducibility brain uptake ratio brain perfusion SPECT Patlak plot method cerebral blood flow (CBF)