Scaffolds of hydroxyl apatite nanoparticles disseminated in 1, 6-diisocyanatohexane-extended poly(1, 4-butylene succinate)/poly(methyl methacrylate) for bone tissue engineering.
Poly(1, 4-butyl succinate) extended 1, 6-diisocyanatohexane (PBSu-DCH) polymers and Polymethylmethacrylate (PMMA) scaffolds decorated with nano hydroxyl apatite have been prepared and characterized for regeneration of bone in cranio-maxillofacial region. Synthesized scaffolds revealed good response in bone regeneration and excellent cell viability in comparison to commercial available glass plate, which lead to better proliferation of MG-63 cell lines. Additionally, they demonstrate high porosity and excellent water retention ability. Moreover, controlled degradation (in pH=7.4) and sustained drug release in pH (4.5 and 7.4) are advantages of these scaffolds to serve as delivery vehicles for therapeutic drugs. Samples also provide the protection against Escherichia coli and Methicillin Resistant Staphylococcus aureus microorganisms which can be helpful for quick recovery of the patient. In-vitro inflammatory response has been assessed via adsorption of human plasma/serum proteins on the surface of the scaffolds. Results suggest that prepared scaffolds have good bone regeneration ability and provide friendly environment for the cell growth with the additional advantage of protection of the surrounding tissues from microbial infection. With all these features, it is speculated that these scaffolds will have wide utility in the area of tissue engineering and regenerative medicine.
['Kaur|Kulwinder|K|', 'Singh|K J|KJ|', 'Anand|Vikas|V|', 'Bhatia|Gaurav|G|', 'Kaur|Raminderjit|R|', 'Kaur|Manpreet|M|', 'Nim|Lovedeep|L|', 'Arora|Daljit Singh|DS|']
D000327:Adsorption D000475:Alkenes D000900:Anti-Bacterial Agents D001798:Blood Proteins D001861:Bone Regeneration D001842:Bone and Bones D002072:Butylene Glycols D016923:Cell Death D045744:Cell Line, Tumor D002470:Cell Survival D065546:Drug Liberation D017886:Durapatite D006801:Humans D006863:Hydrogen-Ion Concentration D017953:Isocyanates D007700:Kinetics D053758:Nanoparticles D011108:Polymers D019904:Polymethyl Methacrylate D013052:Spectrometry, X-Ray Emission D017550:Spectroscopy, Fourier Transform Infrared D023822:Tissue Engineering D054457:Tissue Scaffolds D014867:Water D014961:X-Ray Diffraction
Scaffold Hydroxyl apatite Tissue engineering