Evidence of association between single-nucleotide polymorphisms in lipid metabolism-related genes and type 2 diabetes mellitus in a Chinese population.
Background: Type 2 diabetes mellitus (T2DM) is a complex chronic metabolic disorder triggered by insulin resistance in peripheral tissues. Evidence has shown that lipid metabolism and related genetic factors lead to insulin resistance. Hence, it is meaningful to investigate the association between single-nucleotide polymorphisms (SNPs) in lipid metabolism-related genes and T2DM. Methods: A total of 1,194 subjects with T2DM and 1,274 Non-diabetic subjects (NDM) were enrolled. Five SNPs in three genes (rs864745 in JAZF1, rs35767 in IGF1, and rs4376068, rs4402960, and rs6769511 in IGF2BP2) that contribute to insulin resistance involving lipid metabolism were genotyped using the MassArray method in a Chinese population. Results: The allele and genotypes of rs6769511 in IGF2BP2 were associated with T2DM (P=0.009 and P=0.002, respectively). In inheritance model analysis, compared with the T/T-C/T genotype, the C/C genotype of rs6769511 in IGF2BP2 was a risk factor for the development of T2DM (P<0.001, odds ratio [OR] =1.76; 95% confidence interval [CI]: 1.29-2.42). Haplotype analysis revealed associations of the rs4376068-rs4402960-rs6769511 haplotypes in IGF2BP2 with the development of T2DM (P=0.015). Additionally, rs4376068C-rs4402960T-rs6769511C was a risk haplotype for T2DM (OR=1.179; 95% CI: 1.033-1.346). Conclusion: The rs6769511 in IGF2BP2 was associated with T2DM susceptibility, and the rs4376068-rs4402960-rs6769511 haplotypes in IGF2BP2 was associated with the development of T2DM in a Chinese population.
['Li|Yiping|Y|', 'He|Siqi|S|', 'Li|Chuanyin|C|', 'Shen|Keyu|K|', 'Yang|Man|M|', 'Tao|Wenyu|W|', 'Yang|Ying|Y|', 'Shi|Li|L|', 'Yao|Yufeng|Y|']
D000328:Adult D000483:Alleles D044466:Asians D002681:China D056970:Co-Repressor Proteins D004268:DNA-Binding Proteins D003924:Diabetes Mellitus, Type 2 D005260:Female D020022:Genetic Predisposition to Disease D006239:Haplotypes D006801:Humans D007334:Insulin-Like Growth Factor I D050356:Lipid Metabolism D008297:Male D008875:Middle Aged D020641:Polymorphism, Single Nucleotide D016601:RNA-Binding Proteins
Polymorphisms lipid metabolism-related genes Chinese population T2DM