Long-term effect of non-surgical periodontal treatment on glycaemic control in patients with diabetes with periodontitis: a systematic review and meta-analysis protocol.
INTRODUCTION
Non-surgical periodontal therapy consisting of scaling and root planning has been shown to be effective in the improvement of glycaemic control in patients with diabetes with periodontitis for up to 3 months. However, questions remain about this beneficial effect over a longer period of time. This systematic review and meta-analysis aims to determine the long-term effect (at least 6 months from the therapy) of non-surgical periodontal therapy with or without adjuvant on glycaemic control of patients with diabetes with periodontitis.


METHODS AND ANALYSIS
This systematic review will include randomised control trials with a follow-up period of at least 6 months after initial therapy, with measurement of glycated haemoglobin as the primary endpoint. A literature search will be conducted in MEDLINE, CENTRAL, EMBASE, CINAHL, The Cochrane Oral Health Group Trials Register, and the US National Institutes of Health Trials Registry: ClinicalTrials.gov, from inception to 30 June 2020. Selection of studies, data extraction and bias assessment will be conducted independently by two reviewers. A DerSimonian-Laird random-effect meta-analysis will be conducted to pool studies deemed to be homogeneous. A subgroup analysis will be conducted in case of substantial heterogeneity. Egger's test and observation of the funnel plot will be used to assess publication bias. The statistical analysis will be done using R V.4.0.0 software.


ETHICS AND DISSEMINATION
Since primary data are not collected, ethical approval is not required. The final report will be published in a peer-reviewed journal.


PROSPERO REGISTRATION NUMBER
CRD42020192635.
['Ndjidda Bakari|William|W|0000-0003-4986-7126', 'Diallo|Ahmad Moustapha|AM|', 'Danwang|Celestin|C|0000-0002-7976-4331', 'Nzalie|Rolf Nyah Tuku|RNT|', 'Benoist|Henri Michel|HM|0000-0003-4433-4435']
D003920:Diabetes Mellitus D006442:Glycated Hemoglobin A D000085002:Glycemic Control D006801:Humans D015201:Meta-Analysis as Topic D009909:Oral Health D010518:Periodontitis D000078202:Systematic Reviews as Topic D014481:United States
diabetes & endocrinology oral medicine public health