Scoring System to Predict pt2 in Gallbladder Cancer Based on Carcinoembryonic Antigen and Tumor Diameter.
BACKGROUND AND AIMS
T2 gallbladder cancer requires lymph node dissection for curative resection, whereas simple cholecystectomy is adequate to treat T1 gallbladder cancer. Hence, this study aimed to develop an accurate scoring system to preoperatively predict pT2 in gallbladder cancer.


MATERIAL AND METHODS
We retrospectively assessed data from 57 patients with suspected gallbladder cancer who underwent curative resection between September 2003 and May 2017. Six with apparent invasion of adjacent organs on preoperative images were excluded. We evaluated preoperative computed tomography, magnetic resonance and endoscopic ultrasonographic images, blood biochemistry, and the maximum standard uptake value in fluorodeoxyglucose-positron emission tomography images. We analyzed whether correlations between preoperative findings and the depth of tumor invasion could predict pT2.


RESULTS
The pathological diagnosis was gallbladder cancer in 30 (58.8%) patients, of whom 21 (69.9%) had pT2 or worse. Multivariate analyses selected carcinoembryonic antigen and tumor diameter as independent predictors of pT2 or worse (odds ratios = 1.741 and 1.098, respectively; 95% confidence intervals = 1.004-3.020 and 1.008-1.197, respectively). A regression formula was created using carcinoembryonic antigen and tumor diameter to calculate pT2 predictive scores. The area under the receiver operating characteristics curve of the pT2 predictive score was 0.873.


CONCLUSION
We created a scoring system to predict pT2 in gallbladder cancer using carcinoembryonic antigen and tumor diameter. The present findings suggested that carcinoembryonic antigen is important for the preoperative evaluation of gallbladder cancer.
['Sakamoto|K|K|https://orcid.org/0000-0002-6431-0011', 'Takai|A|A|', 'Ueno|Y|Y|', 'Inoue|H|H|', 'Ogawa|K|K|', 'Takada|Y|Y|']
D000230:Adenocarcinoma D000328:Adult D000368:Aged D000369:Aged, 80 and over D002272:Carcinoembryonic Antigen D002763:Cholecystectomy D005260:Female D005706:Gallbladder Neoplasms D006801:Humans D008297:Male D008875:Middle Aged D009361:Neoplasm Invasiveness D009367:Neoplasm Staging D011237:Predictive Value of Tests D012372:ROC Curve D012189:Retrospective Studies
Gallbladder cancer carcinoembryonic antigen tumor diameter T2 cholecystectomy lymph node metastasis preoperative diagnosis subserosa