Photoprotective and Anti-Inflammatory Properties of Vina-Ginsenoside R7 Ameliorate Ultraviolet B-Induced Photodamage in Normal Human Dermal Fibroblasts.
Vina-ginsenoside R7 (R7) has been exhibited to engage in multiple pharmacological activities, such as antioxidant and anti-inflammatory activities. However, no photoaging-related studies have been performed on R7. Research is being conducted with the aim of assessing whether treatment with R7 has a protective effect on UVB-induced photoaging skin. Our results show that UVB exposure directly reduces matrix metalloproteinase (MMP) secretion through R7 by restraining the AP-1/MAPK pathway and blocks extracellular matrix (ECM) expression degradation. In addition, R7 improves the expression of transforming growth factor beta 1 (TGF-β1), and type I procollagen also facilitates the synthesis of collagen by the TGF-β/Smad signal transduction pathway. Finally, R7 valid blocks nuclear factor-κB (NF-κB) activation and enhances antioxidative stress capacity through activated nuclear factor (erythroid derived 2)-like 2 (Nrf2). In particular, the application of R7 restrains pro-inflammatory cytokines (TNF-α, IL-6, iNOS), which trigger ECM, degrade enzyme production, and suppress vascular endothelial growth factor (VEGF) secretion. In conclusion, R7 may constitute a promising cosmetic ingredient that can protect against skin photodamage resulting from detrimental UVB irradiation.
['Liu|Xiao-Yi|XY|', 'Hwang|Eunson|E|', 'Park|Bom|B|', 'Xiao|Yong-Kun|YK|', 'Yi|Tae-Hoo|TH|http://orcid.org/0000-0001-9369-6542']
D000893:Anti-Inflammatory Agents D002460:Cell Line D002470:Cell Survival D024042:Collagen Type I D004789:Enzyme Activation D005347:Fibroblasts D015971:Gene Expression Regulation, Enzymologic D036145:Ginsenosides D006801:Humans D015850:Interleukin-6 D042541:Intracellular Space D008164:Luminescent Proteins D020781:Matrix Metalloproteinase 1 D019278:Matrix Metalloproteinase 3 D020928:Mitogen-Activated Protein Kinases D016328:NF-kappa B D059748:Proteolysis D012333:RNA, Messenger D017382:Reactive Oxygen Species D015398:Signal Transduction D012867:Skin D053773:Transforming Growth Factor beta1 D014466:Ultraviolet Rays D042461:Vascular Endothelial Growth Factor A
Vina-ginsenoside R7 Photoaging UVB NF-κB Inflammation