Immunohistochemical Phenotypes of Stable and Unstable Occlusive Atherosclerotic Plaques in Coronary Arteries.
We performed a complex morphological analysis of atherosclerotic plaques obtained from 68 men with coronary atherosclerosis during coronary bypass surgery with endarterectomy. The expression of MMP-2 and MMP-9, collagen IV, CD31, CD34, factor VIII, and of smooth muscle cell actin was measured in the samples by morphometric and immunohistochemical methods. The expression of MMP-2 and MMP-9 as well as the intensity of neoangiogenesis estimated by the expression of CD31, CD34, and factor VIII in unstable plaques was significantly higher than in stable ones. Immunohistochemical analysis showed more intensive collagen IV expression in stable plaques. The observed differences in immunohistochemical phenotypes of stable and unstable atherosclerotic plaques reflect peculiarities of morphogenesis of atherosclerotic foci in the coronary arteries determining their further development.
['Murashov|I S|IS|', 'Volkov|A M|AM|', 'Kazanskaya|G M|GM|', 'Kliver|E E|EE|', 'Savchenko|S V|SV|', 'Klochkova|S V|SV|', 'Lushnikova|E L|EL|']
D000199:Actins D000368:Aged D018952:Antigens, CD34 D024141:Collagen Type IV D003324:Coronary Artery Disease D003331:Coronary Vessels D005169:Factor VIII D006801:Humans D007150:Immunohistochemistry D008297:Male D020778:Matrix Metalloproteinase 2 D020780:Matrix Metalloproteinase 9 D008875:Middle Aged D009389:Neovascularization, Pathologic D010641:Phenotype D058226:Plaque, Atherosclerotic D019408:Platelet Endothelial Cell Adhesion Molecule-1
atherosclerotic plaques collagen IV neoangiogenesis immunohistochemistry matrix metalloproteinases