Emergence of vaccine-derived polioviruses, Democratic Republic of Congo, 2004-2011.
Polioviruses isolated from 70 acute flaccid paralysis patients from the Democratic Republic of Congo (DRC) during 2004-2011 were characterized and found to be vaccine-derived type 2 polioviruses (VDPV2s). Partial genomic sequencing of the isolates revealed nucleotide sequence divergence of up to 3.5% in the viral protein 1 capsid region of the viral genome relative to the Sabin vaccine strain. Genetic analysis identified at least 7 circulating lineages localized to specific geographic regions. Multiple independent events of VDPV2 emergence occurred throughout DRC during this 7-year period. During 2010-2011, VDPV2 circulation in eastern DRC occurred in an area distinct from that of wild poliovirus circulation, whereas VDPV2 circulation in the southwestern part of DRC (in Kasai Occidental) occurred within the larger region of wild poliovirus circulation.
['Gumede|Nicksy|N|', 'Lentsoane|Olivia|O|', 'Burns|Cara C|CC|', 'Pallansch|Mark|M|', 'de Gourville|Esther|E|', 'Yogolelo|Riziki|R|', 'Muyembe-Tamfum|Jean Jacques|JJ|', 'Puren|Adrian|A|', 'Schoub|Barry D|BD|', 'Venter|Marietjie|M|']
D000208:Acute Disease D036022:Capsid Proteins D021821:Communicable Diseases, Emerging D015023:Democratic Republic of the Congo D005243:Feces D006801:Humans D015994:Incidence D008969:Molecular Sequence Data D009123:Muscle Hypotonia D010243:Paralysis D010802:Phylogeny D011051:Poliomyelitis D017955:Poliovirus D011055:Poliovirus Vaccine, Oral D017422:Sequence Analysis, DNA D014611:Vaccination
Democratic Republic of Congo DRC poliovirus circulating VDPV vaccine-derived poliovirus viruses