Pharmacokinetic profile of diosgenin and trigonelline following intravenous and oral administration of fenugreek seed extract and pure compound in rabbit.
Diosgenin (DI) and trigonelline (TRG) are the main bioactive compounds of fenugreek seed. A micro-extraction method using magnetic nanocomposites coupled with ion-pairing reversed phase HPLC (RP-HPLC) method was used to determine the analytes in rabbit plasma. The main PK parameters after oral administration of pure DI and the extract were: Cmax: 0.48, 0.057 µg/ml; tmax: 1, 2 h; and t1/2β: 6.23, 15.04 h, respectively. Pure TRG and the extract PK parameters were: Cmax: 0.121, 0.081 µg/ml; tmax: 1.30, 1.30 h; and t1/2β: 20.06, 24.70 h, respectively. Generally, the PK profile of the two compounds was best fitted on the two-compartment model.[Formula: see text].
['Mohamadi|Neda|N|', 'Sharififar|Fariba|F|', 'Ansari|Mehdi|M|https://orcid.org/0000-0003-4637-553X', 'Pournamdari|Mostafa|M|https://orcid.org/0000-0001-8636-9869', 'Rezaei|Mahdieh|M|', 'Hassanabadi|Navid|N|']
D000284:Administration, Oral D000470:Alkaloids D000818:Animals D004144:Diosgenin D015394:Molecular Structure D010936:Plant Extracts D011817:Rabbits D012639:Seeds D029910:Trigonella
pharmacokinetics diosgenin trigonelline Fenugreek magnetic nanoparticles