Metabolically healthy obesity and risk of leukoaraiosis; a population based cross-sectional study.
Metabolically healthy obese (MHO) individual is known to be defended from the metabolic complications of obesity. Leukoaraiosis, which is commonly detected on brain magnetic resonance imaging (MRI), is now recognized as a risk of stroke, dementia and death. However, the association between MHO and the prevalence of leukoaraiosis is unclear. In this cross-sectional study of 796 participants who received a medical examination program, we investigated the association between MHO and the prevalence of leukoaraiosis. We used common clinical markers for definition of metabolic healthy status: blood pressure, fasting plasma glucose, triglycerides and high-density lipoprotein cholesterol concentrations. Obesity was defined by body mass index ≥25.0 kg/m2. We diagnosed leukoaraiosis by fluid-attenuated inversion recovery without hypointensity on T1-weighted images or the presence of a hyperintensity on T2-weighted images. The crude prevalence proportion of leukoaraiosis was 44.5% (case/n = 171/384) in metabolically healthy nonobese (MHNO) individual, 46.3% (44/95) in MHO individual, 62.3% (114/183) in metabolically unhealthy nonobese (MUNO) individual or 56.6% (77/136) in MUO individual. The odds ratios of prevalence of leukoaraiosis were 1.19 (95% CI 0.74-1.90, p = 0.471) for MHO, 1.79 (1.22-2.62, p = 0.003) for MUNO and 1.56 (1.03-2.37, p = 0.037) for MUO individuals after adjusting for sex, age, smoking statues, habit of exercise and alcohol, compared with MHNO individual. We revealed that MHO individuals were not related with the higher risk of leukoaraiosis, whereas MUNO and MUO individuals were.
['Okamura|Takuro|T|', 'Hashimoto|Yoshitaka|Y|', 'Hamaguchi|Masahide|M|', 'Ohbora|Akihiro|A|', 'Kojima|Takao|T|', 'Fukui|Michiaki|M|']
D000367:Age Factors D000368:Aged D001786:Blood Glucose D015992:Body Mass Index D001921:Brain D003430:Cross-Sectional Studies D005260:Female D006801:Humans D049292:Leukoaraiosis D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D000067329:Obesity, Metabolically Benign D012307:Risk Factors D012737:Sex Factors D014280:Triglycerides
Obesity Stroke Cerebral white matter Epidemiology Metabolic syndrome