Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis.
BACKGROUND
There is growing interest in white matter (WM) imaging with positron emission tomography (PET).


OBJECTIVES
We studied the association of cognitive function in late multiple sclerosis (MS) with cortical and WM Pittsburgh compound-B PET (PiB-PET) binding.


METHODS
In the population-based Mayo Clinic Study of Aging, 24 of 4869 participants had MS (12 underwent PiB-PET). Controls were age and sex matched (5:1). We used automated or semi-automated processing for quantitative image analyses and conditional logistic regression for group differences.


RESULTS
MS patients had lower memory ( p = 0.03) and language ( p = 0.02) performance; smaller thalamic volumes ( p = 0.003); and thinner temporal ( p = 0.001) and frontal ( p = 0.045) cortices on magnetic resonance imaging (MRI) than controls. There was no difference in global cortical PiB standardized uptake value ratios between MS and controls ( p = 0.35). PiB uptake was lower in areas of WM hyperintensities compared to normal-appearing white matter (NAWM) in MS ( p = 0.0002). Reduced PiB uptake in both the areas of WM hyperintensities ( r = 0.65; p = 0.02) and NAWM ( r = 0.69; p = 0.01) was associated with decreased visuospatial performance in MS.


CONCLUSION
PiB uptake in the cortex in late MS is not different from normal age-matched controls. PiB uptake in the WM in late MS may be a marker of the large network structures' integrity such as those involved in visuospatial performance.
['Zeydan|Burcu|B|', 'Lowe|Val J|VJ|', 'Schwarz|Christopher G|CG|', 'Przybelski|Scott A|SA|', 'Tosakulwong|Nirubol|N|', 'Zuk|Samantha M|SM|', 'Senjem|Matthew L|ML|', 'Gunter|Jeffrey L|JL|', 'Roberts|Rosebud O|RO|', 'Mielke|Michelle M|MM|', 'Benarroch|Eduardo E|EE|', 'Rodriguez|Moses|M|', 'Machulda|Mary M|MM|', 'Lesnick|Timothy G|TG|', 'Knopman|David S|DS|', 'Petersen|Ronald C|RC|', 'Jack|Clifford R|CR|', 'Kantarci|Kejal|K|', 'Kantarci|Orhun H|OH|']
D000368:Aged D000375:Aging D000814:Aniline Compounds D001921:Brain D003071:Cognition D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D009103:Multiple Sclerosis D049268:Positron-Emission Tomography D019275:Radiopharmaceuticals D013844:Thiazoles D066127:White Matter
Pittsburgh compound-B PET cognition multiple sclerosis myelin thalamus