Structural Modification of Stilbenoids from Acanthopanax leucorrhizus and Their Cytotoxic Activity.
A new cis-stilbenoid, 1,9-dihydroxy-10-methoxy-6H-dibenzo[b,f]oxocin-6-one (2) was isolated from the AcOEt extract of the stem barks of Acanthopanax leucorrhizus, along with three known stilbenoids, 9-hydroxy-10-methoxy-6H-dibenzo[b,f]oxocin-6-one (1), 5-O-methyl-(E)-resveratrol 3-O-β-d-glucopyranoside (3), and (E)-resveratrol 3-O-β-d-xylopyranoside (4). Two derivatives (2a and 2b) were synthesized by the structural modification of compound 2, which exhibited certain cytotoxic activities against HT-29 and HeLa cell lines in vitro. All compounds were structurally characterized by comprehensive analysis of their spectroscopic data and comparison with literature information, and evaluated for their cytotoxic activities against three human tumor cell lines (HL-60, HT-29, and HeLa) by the standard MTT assay in vitro. The results showed that derivatives 2a and 2b exhibited strong activities than compounds 2 against HT-29 and HeLa cell lines.
['Hu|Hao-Bin|HB|', 'Liang|Hai-Peng|HP|', 'Li|Hai-Ming|HM|', 'Yuan|Ru-Nan|RN|', 'Sun|Jiao|J|', 'Wu|Yun|Y|', 'Zhang|La-La|LL|', 'Han|Ming-Hu|MH|']
D002470:Cell Survival D028001:Eleutherococcus D018922:HL-60 Cells D019073:HT29 Cells D006367:HeLa Cells D006801:Humans D009682:Magnetic Resonance Spectroscopy D008968:Molecular Conformation D024301:Plant Bark D010936:Plant Extracts D018547:Plant Stems D013267:Stilbenes
Structural modification Stilbenoids Acanthopanax leucorrhizus Cytotoxic activity Isolation