Elevated serum substance P level as a predictive marker for moderately emetogenic chemotherapy-induced nausea and vomiting: A prospective cohort study.
Chemotherapy-induced nausea and vomiting (CINV) is an unbearable side effect. Identifying high emetic risk patients and providing more active antiemetics strategies are mandatory to improve the tolerability of chemotherapy. In this prospective cohort study, leptin, ghrelin, and substance P were measured at baseline, day 3, and day 14 during the first cycle of chemotherapy. Nausea and vomiting were measured each day for the first 4 days of the first cycle of chemotherapy. Eighty-two patients were enrolled. Colorectal cancer (61%) and gastric cancer (35.4%) were common cancer types. All patients received moderate emetic risk chemotherapy. Forty-five (54.9%) patients had nausea, and 15 (18.3%) patients experienced vomiting. In univariate analysis, a higher level of baseline substance P, which is a target of NK1-RA (Neurokinin 1 receptor antagonist), was a significant predictive marker for chemotherapy-induced nausea [odds ratio (OR): 2.6, 95% confidence interval (CI): 1.02-6.62, p = 0.046]. Regarding chemotherapy-induced vomiting, patients with higher levels of substance P had a greater chance of vomiting [OR: 1.72, 95% CI: 0.49-5.99, p = 0.395] than those with lower levels of substance P. In patients receiving moderate emetic risk chemotherapy, active antiemetics, including NK1-RA, could be considered for those with high levels of substance P.
['Park|Hyung Soon|HS|0000-0003-3879-3109', 'Won|Hye Sung|HS|', 'An|Ho Jung|HJ|', 'Cho|Sung Shim|SS|', 'Kim|Hyun Ho|HH|', 'Sun|Der Sheng|S|', 'Ko|Yoon Ho|YH|', 'Shim|Byoung Yong|BY|0000-0001-6473-786X']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D000971:Antineoplastic Combined Chemotherapy Protocols D064420:Drug-Related Side Effects and Adverse Reactions D004639:Emetics D005260:Female D005500:Follow-Up Studies D006801:Humans D008297:Male D008875:Middle Aged D009325:Nausea D009369:Neoplasms D011379:Prognosis D011446:Prospective Studies D013373:Substance P D015996:Survival Rate D014839:Vomiting
substance P predictive marker nausea vomiting chemotherapy