HHX-5, a derivative of sesquiterpene from Chinese agarwood, suppresses innate and adaptive immunity via inhibiting STAT signaling pathways.
Induction of excessive, prolonged, or dysregulated immune responses causes immunological disorders, such as inflammatory diseases, autoimmune diseases, allergic diseases, and organ-graft rejections. In the present study, we investigated the inhibitory effects of HHX-5, a derivative of sesquiterpene from Chinese agarwood, on innate and adaptive immunity for revealing its potential to treat above immunological disorders. The results showed that HHX-5 significantly inhibited the activation of macrophages and neutrophils which play important roles in innate immunity. Furthermore, HHX-5 strongly suppressed adaptive immunity via inhibiting differentiation of naive CD4+ T cells into Th1, Th2, and Th17 cells and suppressing activation, proliferation and differentiation of CD8+ T cells and B cells. The mechanism study showed that HHX-5 significantly inhibited STAT1 signaling pathway in macrophages and suppressed STAT1, STAT4, STAT5, and STAT6 signaling pathways in naive CD4+ T cells. In conclusion, we demonstrated that HHX-5 can strongly inhibit innate and adaptive immunity via suppressing STAT signaling pathways and has potential to be developed into therapeutic drug for treat immunological disorders.
['Zhu|Zhixiang|Z|', 'Zhao|Yunfang|Y|', 'Huo|Huixia|H|', 'Gao|Xiaoli|X|', 'Zheng|Jiao|J|', 'Li|Jun|J|', 'Tu|Pengfei|P|']
D056704:Adaptive Immunity D000818:Animals D001402:B-Lymphocytes D015496:CD4-Positive T-Lymphocytes D002454:Cell Differentiation D049109:Cell Proliferation D016207:Cytokines D007113:Immunity, Innate D007166:Immunosuppressive Agents D008213:Lymphocyte Activation D020935:MAP Kinase Signaling System D008264:Macrophages D008297:Male D051379:Mice D016328:NF-kappa B D009504:Neutrophils D000067996:RAW 264.7 Cells D050791:STAT Transcription Factors D012717:Sesquiterpenes D015398:Signal Transduction D013154:Spleen D014934:Wood
HHX-5 Sesquiterpene Adaptive immunity STAT signaling pathways Immunological disorder Innate immunity