Metabolic syndrome in relation to risk of meningioma.
BACKGROUND
Meningioma is a frequent primary intracranial tumor, the etiology of which is potentially related to adiposity. Metabolic syndrome (MetS) is an increasingly common disease characterized by having at least three of the following conditions: central adiposity, arterial hypertension, dyslipidemia, and insulin resistance. Only one prior study investigated MetS in relation to meningioma risk and found a positive association between the two.


RESULTS
Among 2,027 cases and 20,269 controls, body mass index was positively associated with meningioma (p-value for trend < 0.0001). Arterial hypertension was also associated with an increased risk of meningioma (OR = 1.34; 95% CI = 1.20- 1.49). By comparison, high-density lipoprotein, triglycerides, fasting serum glucose, and use of ACE-inhibitors, AT-II inhibitors, beta-blockers, diuretics, calcium antagonists, nitrates, or statins were not associated with risk of meningioma.


MATERIALS AND METHODS
We conducted a matched case-control analysis using data from the U.K.-based Clinical Practice Research Datalink (CPRD) to analyse medical conditions and treatments related to MetS in cases with meningioma and meningioma-free controls. We identified all cases with an incident diagnosis of meningioma between 1995 and 2015 and matched each to ten controls on age, sex, calendar time, general practice, and number of years of active history in the CPRD prior to the index date. Exposures were assessed using computerised records. We conducted conditional logistic regression analysis to determine relative risks, estimated as odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for confounding factors.


CONCLUSIONS
Obesity and arterial hypertension are positively associated with risk of meningioma. Further studies are needed to better understand potential underlying biologic mechanisms.
['Seliger|Corinna|C|', 'Meier|Christoph R|CR|', 'Becker|Claudia|C|', 'Jick|Susan S|SS|', 'Proescholdt|Martin|M|', 'Bogdahn|Ulrich|U|', 'Hau|Peter|P|', 'Leitzmann|Michael F|MF|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D016022:Case-Control Studies D002648:Child D002675:Child, Preschool D005260:Female D006801:Humans D007223:Infant D007231:Infant, Newborn D008297:Male D008577:Meningeal Neoplasms D008579:Meningioma D024821:Metabolic Syndrome D008875:Middle Aged D012307:Risk Factors D055815:Young Adult
metabolic syndrome meningioma case-control study epidemiology