SIGN-R1 and complement factors are involved in the systemic clearance of radiation-induced apoptotic cells in whole-body irradiated mice.
Although SIGN-R1-mediated complement activation pathway has been shown to enhance the systemic clearance of apoptotic cells, the role of SIGN-R1 in the clearance of radiation-induced apoptotic cells has not been characterized and was investigated in this study. Our data indicated that whole-body γ-irradiation of mice increased caspase-3(+) apoptotic lymphocyte numbers in secondary lymphoid organs. Following γ-irradiation, SIGN-R1 and complements (C4 and C3) were simultaneously increased only in the mice spleen tissue among the assessed tissues. In particular, C3 was exclusively activated in the spleen. The delayed clearance of apoptotic cells was markedly prevalent in the spleen and liver of SIGN-R1 KO mice, followed by a significant increase of CD11b(+) cells. These results indicate that SIGN-R1 and complement factors play an important role in the systemic clearance of radiation-induced apoptotic innate immune cells to maintain tissue homeostasis after γ-irradiation.
['Park|Jin-Yeon|JY|', 'Loh|SoHee|S|', 'Cho|Eun-hee|EH|', 'Choi|Hyeong-Jwa|HJ|', 'Na|Tae-Young|TY|', 'Nemeno|Judee Grace E|JG|', 'Lee|Jeong Ik|JI|', 'Yoon|Taek Joon|TJ|', 'Choi|In-Soo|IS|', 'Lee|Minyoung|M|', 'Lee|Jae-Seon|JS|', 'Kang|Young-Sun|YS|']
D000818:Animals D017209:Apoptosis D015815:Cell Adhesion Molecules D003165:Complement System Proteins D005720:Gamma Rays D006801:Humans D037181:Lectins, C-Type D008214:Lymphocytes D008221:Lymphoid Tissue D008264:Macrophages D008810:Mice, Inbred C57BL D011956:Receptors, Cell Surface D014916:Whole-Body Irradiation
SIGN-R1 Complement Systemic clearance γ-irradiation Apoptosis