Rattle-Structured Upconversion Nanoparticles for Near-IR-Induced Suppression of Alzheimer's β-Amyloid Aggregation.
Rose bengal (RB)-loaded upconverting nanocomposites are synthesized as a near-infrared (NIR)-responsive inhibitor of Aβ aggregation. Rattle-structured, organosilica shell (ROS) is deposited on NaYF4 :Yb,Er nanocrystals (UCNPs) for high loading efficiency and disaggregation of RB. RB/UCNP@ROS successfully inhibits Aβ self-assembly under NIR irradiation by generating 1 O2 . Furthermore, photoexcited RB/UCNP@ROS is effective in suppressing Aβ-induced cytotoxicity.
['Kuk|Sukeun|S|', 'Lee|Byung Il|BI|', 'Lee|Joon Seok|JS|', 'Park|Chan Beum|CB|']
D000544:Alzheimer Disease D016229:Amyloid beta-Peptides D000818:Animals D016923:Cell Death D007259:Infrared Rays D053758:Nanoparticles D017646:Organosilicon Compounds D016716:PC12 Cells D066329:Protein Aggregates D051381:Rats D012395:Rose Bengal
upconversion nanoparticles β-amyloid self-assembly near-infrared light photosensitizers