Long non-coding RNAs in cancer metabolism.
Altered cellular metabolism is an emerging hallmark of cancer. Accumulating recent evidence links long non-coding RNAs (lncRNAs), a still poorly understood class of non-coding RNAs, to cancer metabolism. Here we review the emerging findings on the functions of lncRNAs in cancer metabolism, with particular emphasis on how lncRNAs regulate glucose and glutamine metabolism in cancer cells, discuss how lncRNAs regulate various aspects of cancer metabolism through their cross-talk with other macromolecules, explore the mechanistic conceptual framework of lncRNAs in reprogramming metabolism in cancers, and highlight the challenges in this field. A more in-depth understanding of lncRNAs in cancer metabolism may enable the development of novel and effective therapeutic strategies targeting cancer metabolism.
['Xiao|Zhen-Dong|ZD|', 'Zhuang|Li|L|', 'Gan|Boyi|B|']
D000818:Animals D015972:Gene Expression Regulation, Neoplastic D052138:Genes, Neoplasm D005947:Glucose D005973:Glutamine D006801:Humans D009369:Neoplasms D062085:RNA, Long Noncoding D015398:Signal Transduction
long non-coding RNAs cancer metabolism AMPK NBR2 c-Myc mTOR tumor suppression