Effect of Acute Emotional Stress on Proteomic Profile of Selected Brain Areas and Lysosomal Proteolysis in Rats with Different Behavioral Activity.
We compared proteome profiles of selected brain areas (cortex, amygdala, hippocampus, and reticular formation) and measured cathepsins B and D activity in liver lysosomal fraction in rats with different behavioral activity under conditions of emotional stress. In passive rats, the expression of some proteins in various brain regions was changed and baseline cathepsin B activity was higher than in active animals. Taken together, the results attest to differences in the adaptive response formation in rats, depending on behavioral features.
['Sharanova|N E|NE|', 'Kirbaeva|N V|NV|', 'Toropygin|I Yu|IY|', 'Khryapova|E V|EV|', 'Koplik|E V|EV|', 'Soto|C Kh|CKh|', 'Pertsov|S S|SS|', 'Vasiliev|A V|AV|']
D000818:Animals D001921:Brain D002401:Cathepsin B D002402:Cathepsin D D006624:Hippocampus D008247:Lysosomes D008297:Male D059748:Proteolysis D040901:Proteomics D051381:Rats D017208:Rats, Wistar D013315:Stress, Psychological
emotional stress proteomics brain cathepsin B cathepsin D