Early screening and treatment of gestational diabetes in high-risk women improves maternal and neonatal outcomes: A retrospective clinical audit.
AIMS
Evidence suggests that screening for gestational diabetes (GDM) occurs too late in pregnancy, when changes in glucose metabolism and fetal growth rates can already be detected. In August 2016 NHS Lothian began screening women with risk factors for GDM during early pregnancy (11-13 weeks). We hypothesised that an earlier identification and treatment of dysglycaemia would improve pregnancy outcomes compared to previous standard care.


METHODS
We compared management and outcomes for singleton pregnancies with GDM delivering at Royal Infirmary Edinburgh, UK, diagnosed through routine or early screening from 01/01/2015-31/10/2017 (routine screening n = 335, early screening n = 241).


RESULTS
Early screening increased the proportion of women diagnosed before 24 weeks' gestation (n = 59/335, 17.6% vs n = 103/241, 42.7%, p < 0.001) but did not change the average monthly rate of diagnosis. Early screening increased the median duration of GDM during pregnancy (71 vs 93 days of gestation, p < 0.001) with no significant changes in the pharmacological management. Early screening improved the primary composite outcome (emergency caesarean section, neonatal hypoglycaemia and macrosomia; n = 138/335, 41.2% vs n = 73/241, 30.3%, adjusted Odds Ratio [95% confidence interval] 0.62 [0.43-0.91].


CONCLUSIONS
There is a role for early screening and management of GDM however it is unclear whether this represents a cost-effective intervention.
['Ryan|David K|DK|', 'Haddow|Laura|L|', 'Ramaesh|Aksha|A|', 'Kelly|Rod|R|', 'Johns|Emma C|EC|', 'Denison|Fiona C|FC|', 'Dover|Anna R|AR|', 'Reynolds|Rebecca M|RM|']
D000328:Adult D016640:Diabetes, Gestational D005260:Female D005320:Fetal Macrosomia D006801:Humans D007003:Hypoglycemia D007231:Infant, Newborn D007232:Infant, Newborn, Diseases D008403:Mass Screening D011247:Pregnancy D011248:Pregnancy Complications D011256:Pregnancy Outcome D011295:Prenatal Care D012189:Retrospective Studies D012307:Risk Factors
Screening Gestational diabetes Diabetes Pregnancy Obesity