Salsolinol: an Unintelligible and Double-Faced Molecule-Lessons Learned from In Vivo and In Vitro Experiments.
Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) is a tetrahydroisoquinoline derivative whose presence in humans was first detected in the urine of Parkinsonian patients on L-DOPA (L-dihydroxyphenylalanine) medication. Thus far, multiple hypotheses regarding its physiological/pathophysiological roles have been proposed, especially related to Parkinson's disease or alcohol addiction. The aim of this review was to outline studies related to salsolinol, with special focus on in vivo and in vitro experimental models. To begin with, the chemical structure of salsolinol together with its biochemical implications and the role in neurotransmission are discussed. Numerous experimental studies are summarized in tables and the most relevant ones are stressed. Finally, the ability of salsolinol to cross the blood-brain barrier and its possible double-faced neurobiological potential are reviewed.
['Kurnik-Łucka|Magdalena|M|', 'Panula|Pertti|P|', 'Bugajski|Andrzej|A|', 'Gil|Krzysztof|K|']
D000437:Alcoholism D000818:Animals D001921:Brain D006801:Humans D007546:Isoquinolines D010300:Parkinson Disease D009435:Synaptic Transmission D044005:Tetrahydroisoquinolines
Salsolinol Tetrahydroisoquinolines Acetaldehyde DMDHIQ+ Dopamine Parkinson’s disease