Changes of orbital tissue volumes and proptosis in patients with thyroid extraocular muscle swelling after methylprednisolone pulse therapy.
PURPOSE
To evaluate the changes of orbital tissue volumes and proptosis after methylprednisolone pulse therapy in thyroid-associated ophthalmopathy (TAO).


METHODS
The cross-sectional areas of orbital tissues and proptosis were measured with magnetic resonance imaging in 40 orbits of 20 patients with TAO before and after methylprednisolone pulse therapy. The volumes of the whole orbit, orbital fatty tissue, and extraocular muscles were calculated. The volumes and proptosis were compared before and after treatment using a paired t test.


RESULTS
Before treatment, the mean volumes were 33.0 ± 4.8 cm(3) in the whole orbit, 19.9 ± 4.1 cm(3) in the orbital fatty tissue, and 4.6 ± 1.2 cm(3) in the total extraocular muscles. After treatment, the mean volumes were 32.5 ± 4.4 cm(3) in the whole orbit, 19.9 ± 3.7 cm(3) in the orbital fatty tissue, and 4.0 ± 1.0 cm(3) in the total extraocular muscles. The mean volumes of the whole orbit (P = 0.17) and orbital fatty tissue (P = 0.82) were not significantly decreased after treatment, while the mean volume of total extraocular muscles was significantly decreased (P < 0.001). The mean proptosis value was 18.9 ± 2.8 mm before treatment and 18.6 ± 3.4 mm after treatment. The mean proptosis value was not significantly decreased after treatment (P = 0.30).


CONCLUSIONS
The volume of orbital fatty tissue seemed to be unchanged after methylprednisolone pulse therapy while that of total extraocular muscles was decreased. The proptosis value seemed to be unchanged after treatment.
['Higashiyama|Tomoaki|T|', 'Nishida|Yasuhiro|Y|', 'Ohji|Masahito|M|']
D000273:Adipose Tissue D000368:Aged D005094:Exophthalmos D005260:Female D005938:Glucocorticoids D049970:Graves Ophthalmopathy D006801:Humans D008279:Magnetic Resonance Imaging D008297:Male D008775:Methylprednisolone D008875:Middle Aged D009801:Oculomotor Muscles D009916:Orbital Diseases D020551:Pulse Therapy, Drug D012189:Retrospective Studies
Volume Proptosis Methylprednisolone pulse therapy Thyroid-associated ophthalmopathy Magnetic resonance imaging