AKP and GGT level can provide an early prediction of first-line treatment efficacy in colorectal cancer patients with hepatic metastases.
Aim: It is important to early evaluate or predict the efficacy to avoid ineffective treatment for most colorectal cancer (CRC) patients with liver metastases. Patients & methods: The medical records of 440 patients with histologically confirmed primary CRC admitted to the Fudan University Shanghai Cancer Center were reviewed. Results: High baseline serum alkaline phosphatase (AKP) and γ-glutamyl transferase (GGT) is associated with worse overall survival. In patients with a high serum AKP and GGT a decreased percentage had high objective response rate and better progression-free survival. Conclusion: Measuring the changes of serum AKP or GGT in CRC patients with hepatic metastases before and after the first cycle of treatment is a convenient, fast and economical way to early predict antitumor treatment efficacy.
['Gong|Zhe|Z|', 'Zhang|Xiaowei|X|', 'Geng|Qirong|Q|', 'Li|Wenhua|W|', 'Huang|Mingzhu|M|', 'Chen|Zhiyu|Z|', 'Sheng|Xuedan|X|', 'Zhang|Wen|W|', 'Guo|Weijian|W|0000-0001-5475-2863']
colorectal cancer hepatic metastases alkaline phosphatase γ-glutamyl transferase therapy efficacy