New 15-membered tetraaza (N4) macrocyclic ligand and its transition metal complexes: spectral, magnetic, thermal and anticancer activity.
Novel tetraamidemacrocyclic 15-membered ligand [L] i.e. naphthyl-dibenzo[1,5,9,12]tetraazacyclopentadecine-6,10,11,15-tetraoneand its transition metal complexes with Fe(II), Co(II), Ni(II), Cu(II), Ru(III) and Pd(II) have been synthesized and characterized by elemental analysis, spectral, thermal as well as magnetic and molar conductivity measurements. On the basis of analytical, spectral (IR, MS, UV-Vis, (1)H NMR and EPR) and thermal studies distorted octahedral or square planar geometry has been proposed for the complexes. The antitumor activity of the synthesized ligand and some complexes against human breast cancer cell lines (MCF-7) and human hepatocarcinoma cell lines (HepG2) has been studied. The complexes (IC50=2.27-2.7, 8.33-31.1μg/mL, respectively) showed potent antitumor activity, towards the former cell lines comparable with their ligand (IC50=13, 26μg/mL, respectively). The results show that the activity of the ligand towards breast cancer cell line becomes more pronounced and significant when coordinated to the metal ion.
['El-Boraey|Hanaa A|HA|', 'EL-Gammal|Ohyla A|OA|']
D000970:Antineoplastic Agents D056831:Coordination Complexes D004578:Electron Spin Resonance Spectroscopy D056945:Hep G2 Cells D006801:Humans D020128:Inhibitory Concentration 50 D007700:Kinetics D008024:Ligands D061986:MCF-7 Cells D047028:Macrocyclic Compounds D060328:Magnetic Phenomena D066244:Proton Magnetic Resonance Spectroscopy D021241:Spectrometry, Mass, Electrospray Ionization D017550:Spectroscopy, Fourier Transform Infrared D013696:Temperature D013818:Thermogravimetry D028561:Transition Elements
Antitumor activity IC(50) Macrocyclic metal complexes Spectral studies Tetraazamacrocyclic