Low expression of long noncoding RNA CASC2 indicates a poor prognosis and regulates cell proliferation in non-small cell lung cancer.
Recently, long noncoding RNAs (lncRNAs) have been shown to have important regulatory roles in human cancer biology. The aim of this study was to evaluate the expression and biological role of lncRNA CASC2 in non-small cell lung cancer (NSCLC). By bioinformatics analysis, we found that CASC2 was significantly decreased in NSCLC. qRT-PCR was performed to investigate the expression of CASC2 in tumor tissues and corresponding non-tumor NSCLC tissues from 76 patients. The lower expression of CASC2 was remarkably correlated with advanced TNM stage and tumor size. Multivariate analyses found that CASC2 expression served as an independent predictor for overall survival of NSCLC. Moreover, overexpression of CASC2 significantly inhibited NSCLC cell proliferation both in vitro and in vivo. In conclusion, our study demonstrated that CASC2 is involved in the development and progression of NSCLC and shows that CASC2 may be a potential diagnostic and target for new therapies in patients with NSCLC.
['He|Xuezhi|X|', 'Liu|Zhili|Z|', 'Su|Jun|J|', 'Yang|Jinsong|J|', 'Yin|Dandan|D|', 'Han|Liang|L|', 'De|Wei|W|', 'Guo|Renhua|R|']
D000072283:A549 Cells D002289:Carcinoma, Non-Small-Cell Lung D045744:Cell Line, Tumor D049109:Cell Proliferation D005260:Female D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008175:Lung Neoplasms D008297:Male D008875:Middle Aged D011379:Prognosis D062085:RNA, Long Noncoding D025521:Tumor Suppressor Proteins
CASC2 Cell proliferation lncRNAs NSCLC