miR-1306-3p targets FBXL5 to promote metastasis of hepatocellular carcinoma through suppressing snail degradation.
This study aimed to elucidate the effect of miR-1306-3p on metastasis of hepatocellular carcinoma (HCC) and potential mechanism involved. miR-1306-3p promoted migration and invasion of HCC in vivo and in vitro. Moreover, miR-1306-3p inhibited snail to enhance its expression via directly targeting FBXL5, thus inducing the epithelial-mesenchymal transition (EMT) in HCC. Intriguingly, miR-1306-3p expression was transcriptionally enhanced by FoxM1. Consistently, miR-1306-3p was upregulated in HCC compared with paracarcinoma and correlated with poor prognosis of HCC patients. Our researches suggest that miR-1306-3p is a tumor enhancer in regulating of HCC metastasis, and miR-1306-3p may be clinically utilized as a factor for the clinical diagnosis and prognosis of HCC.
['He|Zhi-Jiang|ZJ|', 'Li|Wen|W|', 'Chen|Hua|H|', 'Wen|Jian|J|', 'Gao|Yan-Feng|YF|', 'Liu|Yun-Jun|YJ|']
D000818:Animals D014408:Biomarkers, Tumor D006528:Carcinoma, Hepatocellular D045744:Cell Line, Tumor D058750:Epithelial-Mesenchymal Transition D044783:F-Box Proteins D000072278:Forkhead Box Protein M1 D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008113:Liver Neoplasms D008297:Male D008807:Mice, Inbred BALB C D035683:MicroRNAs D009857:Oncogenes D011379:Prognosis D059748:Proteolysis D000071250:Snail Family Transcription Factors D043743:Ubiquitin-Protein Ligase Complexes D023041:Xenograft Model Antitumor Assays
FBXL5 Hepatocellular carcinoma EMT miR-1306–3p microRNAs