Epstein-Barr virus oral shedding and viremia and their association with oral hairy leukoplakia in HIV+ individuals.
OBJECTIVE
To assess the oral shedding and viremia of Epstein-Barr virus (EBV) in HIV-positive patients and their relationship with oral hairy leukoplakia (OHL).


METHODOLOGY
A total of 94 HIV-positive patients were included in the study, in which blood and saliva samples were collected for EBV quantification. Data on gender, age, time of HIV seropositivity, combined antiretroviral therapy (cART), CD4+ T-cell counts, and HIV viral load were collected. OHL diagnosis was based on histopathological examination and EBV in situ hybridization.


RESULTS
The EBV load in the 94 HIV-positive patients was higher in saliva than in blood (2.4 and 1.6, respectively), and there was a positive correlation between EBV oral shedding and viremia (p = 0.001). Twenty (21.27%) patients had OHL and also a higher EBV load in saliva (mean log10  = 3.11) compared to those who had no OHL (p = 0.045). Presence of OHL was only associated with age (p = 0.030).


CONCLUSION
In HIV-positive patients, the presence of OHL was associated with EBV oral shedding but not with viremia, regardless of the amount of circulating CD4+ T cells.
['Rosseto|José Henrique Feijó|JHF|', 'Tenório|Jefferson Rocha|JR|https://orcid.org/0000-0002-6986-9148', 'Mamana|Ana Carolina|AC|', 'Tozetto-Mendoza|Tânia Regina|TR|', 'Andrade|Natália Silva|NS|', 'Braz-Silva|Paulo Henrique|PH|https://orcid.org/0000-0002-1842-9521', 'Ortega|Karem L|KL|https://orcid.org/0000-0002-9573-2858']
Epstein-Barr virus oral hairy leukoplakia oral manifestations of HIV