Clinical factors indicating the presence of malignant lymphoma before lymph node dissection.
CONCLUSION
Lymph node swelling in the neck is one of the initial symptoms of malignant lymphoma (ML). The present study showed that clinical factors including higher age, higher level of maximum standardized uptake value (SUV-max) of positron-emission tomography, elevated serum lactate dehydrogenase (LDH), and elevated serum soluble interleukin-2 receptor (sIL-2R) were all useful indicators to suggest the diagnosis of ML, so may be helpful in the selection of patients for lymph node dissection.


OBJECTIVE
Lymph node dissection is essential for the diagnosis of ML. The factors important for the diagnosis of ML were investigated, to establish surgical indicators.


METHODS
Preoperative data including age, number and side of lymph nodes, SUV-max, serum LDH, serum sIL-2R, and size of lymph nodes were obtained from medical records. The cut-off level for each factor was calculated using the Youden Index for logistic regression analysis.


RESULTS
Multivariate logistic regression analysis showed that the following factors were associated with ML: higher age (≥ 53 years), higher level of SUV-max (≥ 9.0), elevated serum LDH (≥ 203 U/L), elevated serum sIL-2R (≥ 2590 U/ml), with odds ratios of 3.7, 4.9, 3.7, and 11.9, respectively.
['Okumura|Yuri|Y|', 'Nomura|Kazuhiro|K|', 'Kikuchi|Toshiaki|T|', 'Suzuki|Takahiro|T|', 'Hidaka|Hiroshi|H|', 'Ogawa|Takenori|T|', 'Katori|Yukio|Y|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D005260:Female D006801:Humans D008197:Lymph Node Excision D008198:Lymph Nodes D008223:Lymphoma D008297:Male D008875:Middle Aged D009361:Neoplasm Invasiveness D009367:Neoplasm Staging D011379:Prognosis D055815:Young Adult
Positron-emission tomography lactate dehydrogenase soluble interleukin-2 receptor