Insulin detemir versus glyburide in women with gestational diabetes mellitus.
AIM
To evaluate the safety, efficacy and pregnancy outcomes of insulin detemir (IDet) versus glyburide treatment in women with gestational diabetes mellitus (GDM).


METHODS
We conducted a retrospective cohort study of women with GDM who were treated with either glyburide or IDet for GDM in a university-affiliated tertiary hospital.


RESULTS
Ninety-one patients with GDM were enrolled, 62 were administered glyburide and 29 IDet. Maternal age, pregestational body mass index (BMI) and rate of abnormal oral glucose tolerance test (OGTT) blood glucose values were not significantly different between groups. Good glycemic control rates were comparable. Hypoglycemic episodes were reported only in the glyburide group (19.4% versus 0%, p = 0.01). Maternal weight gain during pregnancy was significantly higher among women in the glyburide group (8.8 ± 5.1 kg, p < 0.001) compared to those in the IDet group (2.1 ± 19.9 kg, p = 0.71).


CONCLUSIONS
To the best of our knowledge, this is the first study on IDet treatment in patients with GDM. By our preliminary results, IDet is a viable treatment option in women with GDM. Further large prospective studies are needed to determine the efficacy and safety of IDet in GDM patients.
['Koren|Ronit|R|', 'Ashwal|Eran|E|', 'Hod|Moshe|M|', 'Toledano|Yoel|Y|']
D000328:Adult D016640:Diabetes, Gestational D005260:Female D005905:Glyburide D006801:Humans D007004:Hypoglycemic Agents D000069057:Insulin Detemir D017063:Outcome Assessment, Health Care D011247:Pregnancy D011256:Pregnancy Outcome D012189:Retrospective Studies
insulin detemir glyburide Gestational diabetes hypoglycemia