Impact of Serum Leptin to Adiponectin Ratio on Regression of Metabolic Syndrome in High-Risk Individuals: The ARIRANG Study.
PURPOSE
The ratio of serum leptin to adiponectin (L/A ratio) could be used as a marker for insulin resistance. However, few prospective studies have investigated the impact of L/A ratio on improvement of metabolic components in high-risk individuals with metabolic syndrome. We examined the association between L/A ratio and the regression of metabolic syndrome in a population-based longitudinal study.


MATERIALS AND METHODS
A total of 1017 subjects (431 men and 586 women) with metabolic syndrome at baseline (2005-2008) were examined and followed (2008-2011). Baseline serum levels of leptin and adiponectin were analyzed by radioimmunoassay. Area under the receiver operating characteristics curve (AUROC) analyses were used to assess the predictive ability of L/A ratio for the regression of metabolic syndrome.


RESULTS
During an average of 2.8 years of follow-up, metabolic syndrome disappeared in 142 men (32.9%) and 196 women (33.4%). After multivariable adjustment, the odds ratios (95% confidence interval) for regression of metabolic syndrome in comparisons of the lowest to the highest tertiles of L/A ratio were 1.84 (1.02-3.31) in men and 2.32 (1.37-3.91) in women. In AUROC analyses, L/A ratio had a greater predictive power than serum adiponectin for the regression of metabolic syndrome in both men (p=0.024) and women (p=0.019).


CONCLUSION
Low L/A ratio is a predictor for the regression of metabolic syndrome. The L/A ratio could be a useful clinical marker for management of high-risk individuals with metabolic syndrome.
['Kang|Dae Ryong|DR|', 'Yadav|Dhananjay|D|', 'Koh|Sang Baek|SB|', 'Kim|Jang Young|JY|', 'Ahn|Song Vogue|SV|']
D052242:Adiponectin D000328:Adult D015415:Biomarkers D005260:Female D006801:Humans D007333:Insulin Resistance D020738:Leptin D008137:Longitudinal Studies D008297:Male D024821:Metabolic Syndrome D008875:Middle Aged D016017:Odds Ratio D011159:Population Surveillance D011446:Prospective Studies
Leptin adiponectin metabolic syndrome insulin resistance prospective study