Smartphone-Flashlight-Mediated Remote Control of Rapid Insulin Secretion Restores Glucose Homeostasis in Experimental Type-1 Diabetes.
Emerging digital assessment of biomarkers by linking health-related data obtained from wearable electronic devices and embedded health and fitness sensors in smartphones is opening up the possibility of creating a continuous remote-monitoring platform for disease management. It is considered that the built-in flashlight of smartphones may be utilized to remotely program genetically engineered designer cells for on-demand delivery of protein-based therapeutics. Here, the authors present smartphone-induced insulin release in β-cell line (iβ-cell) technology for traceless light-triggered rapid insulin secretion, employing the light-activatable receptor melanopsin to induce calcium influx and membrane depolarization upon illumination. This iβ-cell-based system enables repeated, reversible secretion of insulin within 15 min in response to light stimulation, with a high induction fold both in vitro and in vivo. It is shown that programmable percutaneous remote control of implanted microencapsulated iβ-cells with a smartphone's flashlight rapidly reverses hyperglycemia in a mouse model of type-1 diabetes.
['Mansouri|Maysam|M|', 'Xue|Shuai|S|', 'Hussherr|Marie-Didiée|MD|', 'Strittmatter|Tobias|T|', 'Camenisch|Gieri|G|', 'Fussenegger|Martin|M|0000-0001-8545-667X']
D000818:Animals D003920:Diabetes Mellitus D005947:Glucose D006706:Homeostasis D007328:Insulin D000078790:Insulin Secretion D051379:Mice D000068997:Smartphone
type-1 diabetes smartphone cell-based therapies optogenetics synthetic biology