Fabrication of chitosan/graphene oxide composite aerogel microspheres with high bilirubin removal performance.
Functional chitosan/graphene oxide (CS/GO) composite aerogel microspheres were fabricated via CO2 supercritical drying, which displayed excellent performance for bilirubin removal. The morphology and chemical structure of CS/GO composite aerogel microspheres were characterized, which illustrated a nanoporous structure with a maximum specific surface area of 174.69 m2/g, and a special pore size distribution at 20-40 nm, also a good mechanical property. Importantly, the composite aerogel microspheres (10% GO) revealed a large adsorption capacity (178.25 mg/g) for bilirubin within 2 h. Dynamic adsorption experiment illustrated that the aerogel microspheres adsorbed much more bilirubin with a shorter equilibrium time of about 30 min. Besides, the adsorption mechanism of bilirubin by the CS/GO composite aerogel microspheres was investigated through the relevant model fitting, including adsorption kinetics and adsorption isotherm, which illustrated that the mechanism included both physical and chemical processes, but chemical adsorption was dominated. Adsorption isotherm indicated that bilirubin adsorption by the microspheres was fitted well with Freundlich isotherm, which ascribed to multilayer adsorption. After five adsorption-desorption cycles, the adsorption capacity still maintains large adsorption capacity. In addition, the hemolysis rate and coagulation time tests presented the good blood compatibility for the adsorbents. Therefore, the CS/GO composite aerogel microspheres with rapid, high adsorption capacity and good blood compatibility might be promising for hyperbilirubinemia treatment.
['Wu|Keke|K|', 'Liu|Xiaoyan|X|', 'Li|Zhentao|Z|', 'Jiao|Yanpeng|Y|', 'Zhou|Changren|C|']
D000327:Adsorption D001663:Bilirubin D048271:Chitosan D004912:Erythrocytes D006108:Graphite D006461:Hemolysis D006801:Humans D020100:Hydrogels D008863:Microspheres D010314:Partial Thromboplastin Time D016062:Porosity D011517:Prothrombin Time
Composite aerogel microspheres Bilirubin adsorption Blood compatibility Hyperbilirubinemia CO(2) supercritical drying