In vitro analysis of a physiological strain sensor formulated from a PEDOT:PSS functionalized carbon nanotube-poly(glycerol sebacate urethane) composite.
Biodegradable strain sensors able to undergo controlled degradation following implantation have recently received significant interest as novel approaches to detect pathological tissue swelling or non-physiological stresses. In this study, the physicomechanical, electrochemical and active pressure sensing behavior of an electrically conductive and biodegradable poly(glycerol sebacate urethane) (PGSU) composite, reinforced with poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) functionalized carbon nanotubes (CNTs), was evaluated in vitro. Analysis of these PGSU-CNTs composites demonstrated that the incorporation of functionalized CNTs into a biodegradable elastomer resulted in enhanced mechanical strength, conductivity and tailored matrix biodegradation. PGSU-CNT composites were subsequently formulated into flexible and active pressure sensors which demonstrated optimal sensitivity to applied 1% uniaxial tensile strains. Finally, cytocompatibility analysis a with primary neural culture confirmed that PGSU-CNT composites exhibited low cytotoxicity, and supported neuron adhesion, viability, and proliferation in vitro.
['Tadayyon|Ghazal|G|', 'Krukiewicz|Katarzyna|K|', 'Britton|James|J|', 'Larrañaga|Aitor|A|', 'Vallejo-Giraldo|Catalina|C|', 'Fernandez-Yague|Marc|M|', 'Guo|Yina|Y|', 'Orpella-Aceret|Gemma|G|', 'Li|Lu|L|', 'Poudel|Anup|A|', 'Biggs|Manus J P|MJP|']
D019086:Bridged Bicyclo Compounds, Heterocyclic D005990:Glycerol D037742:Nanotubes, Carbon D011108:Polymers D014520:Urethane
Strain sensor PEDOT Poly(glycerol sebacate urethane) Carbon nanotubes Biodegradable polymer