Biological properties of nanostructured Ti incorporated with Ca, P and Ag by electrochemical method.
TiO2 nanotube arrays were synthesized on Ti surface by anodic oxidation. The elements of Ca and P were simultaneously incorporated during nanotubes growth in SBF electrolyte, and then Ag was introduced to nanotube arrays by cathodic deposition, which endowed the good osseointegration and antibacterial property of Ti. The bioactivity of the Ti surface was evaluated by simulated body fluid soaking test. The biocompatibility was investigated by in vitro cell culture test. And the antibacterial effect against Staphylococcus aureus was examined by the bacterial counting method. The results showed that the incorporation of Ca, P and Ag elements had no significant influence on the formation of nanotube arrays on Ti surface during electrochemical treatment. Compared to the polished or nanotubular Ti surface, TiO2 nanotube arrays incorporated with Ca, P and Ag increased the formation of bone-like apatite in simulated body fluid, enhanced cell adhesion and proliferation, and inhibited the bacterial growth. Based on these results, it can be concluded that the nanostructured Ti incorporated with Ca, P and Ag by electrochemical method has promising applications as implant material.
['Li|Baoe|B|', 'Hao|Jingzu|J|', 'Min|Yang|Y|', 'Xin|Shigang|S|', 'Guo|Litong|L|', 'He|Fei|F|', 'Liang|Chunyong|C|', 'Wang|Hongshui|H|', 'Li|Haipeng|H|']
D000900:Anti-Bacterial Agents D018407:Bacterial Physiological Phenomena D002118:Calcium D002470:Cell Survival D020099:Coated Materials, Biocompatible D004595:Electroplating D008422:Materials Testing D053768:Metal Nanoparticles D043942:Nanotubes D016348:Osseointegration D010316:Particle Size D010758:Phosphorus D012834:Silver D013499:Surface Properties D014025:Titanium
Electrochemical method Antibacterial property Bioactivity Biocompatibility Titanium