Measuring senescence rates of patients with end-stage renal disease while accounting for population heterogeneity: an analysis of data from the ERA-EDTA Registry.
PURPOSE
Although a population's senescence rate is classically measured as the increase in mortality rate with age on a logarithmic scale, it may be more accurately measured as the increase on a linear scale. Patients on dialysis, who suffer from accelerated senescence, exhibit a smaller increase in their mortality rate on a logarithmic scale, but a larger increase on a linear scale than patients with a functioning kidney transplant. However, this comparison may be biased by population heterogeneity.


METHODS
Follow-up data on 323,308 patients on dialysis and 91,679 patients with a functioning kidney transplant were derived from the ERA-EDTA Registry. We measured the increases in their mortality rates using Gompertz frailty models that allow individual variation in this increase.


RESULTS
According to these models, the senescence rate measured as the increase in mortality rate on a logarithmic scale was smaller in patients on dialysis, while the senescence rate measured as the increase on a linear scale was larger in patients on dialysis than patients with a functioning kidney transplant.


CONCLUSIONS
Also when accounting for population heterogeneity, a population's senescence rate is more accurately measured as the increase in mortality rate on a linear scale than a logarithmic scale.
['Koopman|Jacob J E|JJ|', 'Kramer|Anneke|A|', 'van Heemst|Diana|D|', 'Åsberg|Anders|A|', 'Beuscart|Jean-Baptiste|JB|', 'Buturović-Ponikvar|Jadranka|J|', 'Collart|Frederic|F|', 'Couchoud|Cécile G|CG|', 'Finne|Patrik|P|', 'Heaf|James G|JG|', 'Massy|Ziad A|ZA|', 'De Meester|Johan M J|JM|', 'Palsson|Runolfur|R|', 'Steenkamp|Retha|R|', 'Traynor|Jamie P|JP|', 'Jager|Kitty J|KJ|', 'Putter|Hein|H|']
D000367:Age Factors D000368:Aged D000375:Aging D002423:Cause of Death D005260:Female D006801:Humans D007676:Kidney Failure, Chronic D016030:Kidney Transplantation D016014:Linear Models D016015:Logistic Models D008297:Male D008875:Middle Aged D012042:Registries D006435:Renal Dialysis D018570:Risk Assessment D012737:Sex Factors D016019:Survival Analysis
Senescence Senescence rate End-stage renal disease Population heterogeneity Mortality rate Aging Dialysis Kidney transplantation Frailty Gompertz model