Obesity and hypertension.
Obesity and in particular the excessive visceral fat distribution is accompanied by several alterations at hormonal, inflammatory and endothelial level. These alterations induce a stimulation of several other mechanisms that contribute to the hypertensive state and on the other side to increase the cardiovascular morbidity. In these chapter we will examine the main mechanisms of obesity and obesity-related hypertension and in particular the role of sympathetic nervous system, the alterations of the renal function and at the microvascular level. We will also depict the role of insulin resistance as factor stimulating and potentiating the other mechanisms. The second part will be focalized on the major target organ damage linked with obesity and obesity-related hypertension. We will finally describe the management and treatment of obesity and the antihypertensive drug therapies more effective in hypertensive obeses.
['Seravalle|Gino|G|', 'Grassi|Guido|G|']
D000818:Animals D019440:Anti-Obesity Agents D001158:Arteries D050110:Bariatric Surgery D004035:Diet Therapy D006321:Heart D006801:Humans D006973:Hypertension D007004:Hypoglycemic Agents D008019:Life Style D009765:Obesity
Hypertension Visceral fat distribution Target organ damage Treatment Cardiovascular risk Pathophysiological mechanisms