Uric acid is independent and inversely associated to glomerular filtration rate in young adult Brazilian individuals.
BACKGROUND AND AIMS
Uric acid, the end-product of human purine metabolism, is associated with hypertension, diabetes and obesity. It has also been independently associated with the onset of chronic kidney disease in several populations. In this study, the association between serum uric acid (SUA) level and estimated glomerular filtration rate (eGFR) was investigated in healthy individuals belonging to two Brazilian birth cohorts.


METHODS AND RESULTS
Data from 3541 to 3482 individuals, aged 30 and 22-years old, respectively, was included. eGFR was calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation based on creatinine measurement. Regression analyses were sex-stratified due to interaction between SUA and sex (p < 0.001) and adjusted for perinatal, cardiometabolic and behavioral variables. We observed an inverse association between eGFR and SUA even after adjustment. In the highest tertile (3rd) of SUA, the eGFR coefficients at 30-years were-0.21 (95%CI -0.24;-0.18) for men and -0.20 (95%CI -0.23; -0.17) for women; at 22-years, were -0.09 (95%CI -0.12;-0.05) for men and -0.13 (95%CI -0.15; -0.10) for women. Higher differences among exponential means (95% CI) of eGFR between the 1st and the 3rd tertile of SUA were seen in older participants, being more pronounced in men. At 22-years, the highest difference was found in women.


CONCLUSIONS
In young healthy individuals from a low-middle income country, SUA level was inversely associated with eGFR. Gender-related differences in eGFR according tertiles of SUA were higher in men at 30-years and in women at 22-years.
['Oliveira|Isabel O|IO|', 'Mintem|Gicele C|GC|', 'Oliveira|Paula D|PD|', 'Freitas|Deise F|DF|', 'Brum|Clarice B|CB|', 'Wehrmeister|Fernando C|FC|', 'Gigante|Denise P|DP|', 'Horta|Bernardo L|BL|', 'Menezes|Ana Maria B|AMB|']
D000328:Adult D000367:Age Factors D015415:Biomarkers D001938:Brazil D003430:Cross-Sectional Studies D005260:Female D005919:Glomerular Filtration Rate D006801:Humans D033461:Hyperuricemia D007668:Kidney D007674:Kidney Diseases D008297:Male D011379:Prognosis D012307:Risk Factors D012737:Sex Factors D014527:Uric Acid D055815:Young Adult
Uric acid eGFR Gender Kidney function Risk factors