Gold nanorods and curcumin-loaded nanomicelles for efficient in vivo photothermal therapy of Barrett's esophagus.
AIM
Provide an enhanced local drug delivery, nanoparticle(s) to minimize systemic effects and achieve enhanced permeability and drug retention into abnormal cells and stroma.


MATERIALS & METHODS
Here a simultaneous loading of lipophilic gold nanorods (GNRs) and curcumin into polymeric nanomicelles made of biocompatible PLGA-b-PEG copolymer through a double re-emulsification process has been developed.


RESULTS
Initial results in vitro on Barrett's esophagus and esophageal adenocarcinoma cell lines demonstrated a significant reduction in cell viability with curcumin and GNRs exposure (p < 0.05). In vivo Barrett's-associated animal model confirmed these results with successful in vivo demonstrated eradication of all high-grade dysplastic premalignant cancer cells.


CONCLUSION
The synthesis of this novel nanosystem containing GNRs and curcumin is safe and effective in treating and eradicating premalignant esophageal adenocarcinoma.
['Martin|Robert C G|RC|', 'Locatelli|Erica|E|', 'Li|Yan|Y|', 'Zhang|Weizhong|W|', 'Li|Suping|S|', 'Monaco|Ilaria|I|', 'Franchini|Mauro Comes|MC|']
D000818:Animals D001471:Barrett Esophagus D045744:Cell Line, Tumor D002470:Cell Survival D003474:Curcumin D016503:Drug Delivery Systems D004947:Esophagus D006046:Gold D006801:Humans D008823:Micelles D043942:Nanotubes D010789:Phototherapy D011092:Polyethylene Glycols D011098:Polyglactin 910 D051381:Rats
gold nanorods photothermal therapy Barrett's esophagus curcumin codelivery nanomedicine