Lipophilic gold(I) complexes with 1,3,4-oxadiazol-2-thione or 1,3-thiazolidine-2-thione moieties: synthesis and their cytotoxic and antimicrobial activities.
Novel lipophilic gold(I) complexes containing 1,3,4-oxadiazol-2-thione or 1,3-thiazolidine-2-thione derivatives were synthesized and characterized by IR, high resolution mass spectrometry, and 1H, 13C 31P NMR. The cytotoxicity of the compounds was evaluated considering cisplatin and/or auranofin as reference in different tumor cell lines: colon cancer (CT26WT), metastatic skin melanoma (B16F10), breast adenocarcinoma (MCF-7), cervical carcinoma (HeLa), glioblastoma (M059 J). Normal human lung fibroblasts (GM07492-A) and kidney normal cell (BHK-21) were also evaluated. The gold(I) complexes were more active than their respective free ligands and cisplatin. Furthermore, antibacterial activity was evaluated against Gram-positive bacteria Staphylococcus aureus ATCC 25213, Staphylococcus epidermidis ATCC 12228 and Gram-negative bacteria Escherichia coli ATCC 11229 and Pseudomonas aeruginosa ATCC 27853 and expressed as the minimum inhibitory concentration (MIC). The complexes exhibited lower MIC values when compared to the ligands and chloramphenicol against Gram-positive bacteria and Gram-negative bacteria. Escherichia coli was sensitive one to the action of gold(I) complexes.
['de Almeida|Angelina Maria|AM|', 'de Oliveira|Bruno Assis|BA|', 'de Castro|Pedro Pôssa|PP|', 'de Mendonça|Camille Carvalho|CC|', 'Furtado|Ricardo Andrade|RA|', 'Nicolella|Heloiza Diniz|HD|', 'da Silva|Vânia Lúcia|VL|', 'Diniz|Cláudio Galuppo|CG|', 'Tavares|Denise Crispim|DC|', 'Silva|Heveline|H|', 'de Almeida|Mauro Vieira|MV|']
D000818:Animals D000900:Anti-Bacterial Agents D000970:Antineoplastic Agents D045744:Cell Line, Tumor D060326:Chemistry Techniques, Synthetic D006224:Cricetinae D004353:Drug Evaluation, Preclinical D004926:Escherichia coli D006801:Humans D009682:Magnetic Resonance Spectroscopy D051379:Mice D008826:Microbial Sensitivity Tests D050607:Organogold Compounds D011550:Pseudomonas aeruginosa D013211:Staphylococcus aureus D013329:Structure-Activity Relationship D013871:Thiones
Lipophilicity Gold(I) complex Antibacterial Antitumor Azole