Targeting cancer with hyaluronic acid-based nanocarriers: recent advances and translational perspectives.
Hyaluronic acid is a natural polysaccharide that has been widely explored for the development of anticancer therapies due to its ability to target cancer cells. Moreover, advances made in the last decade have revealed the versatility of this biomaterial in the design of multifunctional carriers, intended for the delivery of a variety of bioactive molecules, including polynucleotides, immunomodulatory drugs and imaging agents. In this review, we aim to provide an overview of the major recent achievements in this field, highlighting the application of the newly developed nanostructures in combination therapies, immunomodulation and theranostics. Finally, we will discuss the main challenges and technological advances that will allow these carriers to be considered as candidates for clinical development.
['Cadete|Ana|A|', 'Alonso|María José|MJ|']
D000276:Adjuvants, Immunologic D000818:Animals D000970:Antineoplastic Agents D004337:Drug Carriers D016503:Drug Delivery Systems D006801:Humans D006820:Hyaluronic Acid D007167:Immunotherapy D050997:Nanomedicine D053758:Nanoparticles D009369:Neoplasms D057170:Translational Research, Biomedical
hyaluronic acid cancer nanotechnology immunotherapy translational research