Serological Profiling of Group A Streptococcus Infections in Acute Rheumatic Fever.
Rheumatic fever is a serious post-infectious sequela of Group A Streptococcus (GAS). Prior GAS exposures were mapped in sera using a large panel of M-type specific peptides. Rheumatic fever patients had serological evidence of significantly more GAS exposures than matched controls suggesting immune priming by repeat infections contributes to pathogenesis.
['Lorenz|Natalie|N|', 'Ho|Timothy Kc|TK|', 'McGregor|Reuben|R|', 'Davies|Mark R|MR|', 'Williamson|Deborah A|DA|', 'Gurney|Jason K|JK|', 'Smeesters|Pierre R|PR|', 'Baker|Michael G|MG|', 'Moreland|Nicole J|NJ|']
Group A Streptococcus rheumatic fever immune priming emm-cluster emm-type