Survival of Patients with Cystic Fibrosis Depending on Mutation Type and Nutritional Status.
The purpose of the study was to evaluate the influence of nutrition and of the severity of mutation type on survival rate in cystic fibrosis (CF) patients. Data were longitudinally collected from 60 hospitalized adult CF patients, aged 18-50. The variables consisted of body mass index (BMI) ratio, Cole's BMI cut-off points, severity of mutation type, and survival rate of CF patients. We found that the mean BMI was strongly associated with the severity of mutation type and was significantly lower in patients with severe mutations of grade I and II. The mutation type significantly affected the patients' survival rate; survival was greater in patients with mild and undefined mutation types. The BMI and Cole's cut-off points also had a significant influence on survival rate. CF patients, who suffered from malnutrition and emaciation, had a shorter survival rate than those with proper nutritional status. In conclusion, the study findings confirmed a significant effect of nutritional status and of mutation type on survival rate of CF patients.
['Szwed|A|A|', 'John|A|A|', 'Goździk-Spychalska|J|J|', 'Czaiński|W|W|', 'Czerniak|W|W|', 'Ratajczak|J|J|', 'Batura-Gabryel|H|H|']
D000328:Adult D015992:Body Mass Index D003550:Cystic Fibrosis D005260:Female D006801:Humans D053208:Kaplan-Meier Estimate D008297:Male D008875:Middle Aged D009154:Mutation D009752:Nutritional Status D011336:Probability D055815:Young Adult
Cystic fibrosis Mutation Nutritional status Body mass index Life expectancy