Angiogenic Properties of Placenta-Derived Extracellular Vesicles in Normal Pregnancy and in Preeclampsia.
Angiogenesis is one of the main processes that coordinate the biological events leading to a successful pregnancy, and its imbalance characterizes several pregnancy-related diseases, including preeclampsia. Intracellular interactions via extracellular vesicles (EVs) contribute to pregnancy's physiology and pathophysiology, and to the fetal-maternal interaction. The present review outlines the implications of EV-mediated crosstalk in the angiogenic process in healthy pregnancy and its dysregulation in preeclampsia. In particular, the effect of EVs derived from gestational tissues in pro and anti-angiogenic processes in the physiological and pathological setting is described. Moreover, the application of EVs from placental stem cells in the clinical setting is reported.
['Gebara|Natalia|N|', 'Correia|Yolanda|Y|0000-0002-1940-9661', 'Wang|Keqing|K|', 'Bussolati|Benedetta|B|0000-0002-3663-5134']
D000818:Animals D000067128:Extracellular Vesicles D005260:Female D006801:Humans D009389:Neovascularization, Pathologic D010920:Placenta D011225:Pre-Eclampsia D011247:Pregnancy
extracellular vesicles preeclampsia angiogenesis