Lignans from the roots of Acorus tatarinowii Schott ameliorate β amyloid-induced toxicity in transgenic Caenorhabditis elegans.
A novel tetralignan, tatarinan T (1) with the rare C8-C7' linkage pattern, along with a known monolignan (2) were isolated from the roots of Acorus tatarinowii Schott. Their chemical structures were elucidated on the basis of NMR and X-ray diffraction analysis. We evaluated the protective effects of two rare lignans against β-amyloid toxicity by using CL4176 transgenic C. elegans model for the first time, and found that they significantly delayed paralysis of worms at the concentration of 100 μM. Compound 2 exhibited the more potential protective effect against β-amyloid toxicity, its value of PT50 extended up to 62.3% at 100 μM compared with control, especially, it still has 30.8% extension at 10 μM.
['Luo|Xiao-Hua|XH|', 'Zhang|Ying-Ying|YY|', 'Chen|Xin-Yan|XY|', 'Sun|Meng-Lu|ML|', 'Li|Shan|S|', 'Wang|Hong-Bing|HB|']
D029023:Acorus D016229:Amyloid beta-Peptides D000818:Animals D030801:Animals, Genetically Modified D017173:Caenorhabditis elegans D004365:Drugs, Chinese Herbal D017705:Lignans D015394:Molecular Structure D010936:Plant Extracts D018517:Plant Roots
Lignan Acorus tatarinowii C. elegans Paralysis