The efficacy and safety of rotigotine transdermal patch for the treatment of sleep disorders in Parkinson's disease: a meta-analysis.
OBJECTIVES
Sleep disturbances are one of the most common non-motor symptoms in Parkinson's disease (PD), and more frequently in advancing stage, almost 67-78.6% of PD patients experience some form of sleep disturbance [1-3]. Our objective is to conduct a meta-analysis of randomized controlled trials to demonstrate the efficacy and safety of rotigotine (RTG) transdermal patch for the treatment of sleep disorder in PD.


METHODS
RevMan5.3 from the Cochrane Library was used to conduct a meta-analysis, primary outcome measure was score of sleep scale in Parkinson's Disease, the mean change in scores of each subscale was treated as a continuous variable and the weighted mean difference (WMD) was calculated as the difference between the mean scale of sleep score in the treatment and control groups.


RESULTS
A total of five studies were included, and primary outcome measured by "PDSS" or "PDSS-2" score revealed a significant improvement in RTG treated patients compared to control [WMD: -6.66, 95% CI: (-8.54, -4.79), p < 0.0001], after the removal of two articles with high heterogeneity, the meta-analysis conclusion remained robust to methodological changes [WMD -3.90, 95%CI (-6.11, -1.69), p = 0.0005] and distinctly decreased heterogeneity was shown in the final result (I2 = 7%).


CONCLUSIONS
As for the safety of RTG, it is well tolerated and safe [WMD: 1.68, 95%CI: (1.33, 2.13), p < 0.0001], application site reaction and nausea are among the most frequent side effects.
['Fei|Lu|L|', 'Zhou|Dao|D|', 'Ding|Zheng-Tong|ZT|']
D018491:Dopamine Agonists D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D010300:Parkinson Disease D016032:Randomized Controlled Trials as Topic D012893:Sleep Wake Disorders D013764:Tetrahydronaphthalenes D013876:Thiophenes D057968:Transdermal Patch D016896:Treatment Outcome
Efficacy and safety Rotigotine transdermal patch Sleep disorders Parkinson's disease Meta-analysis