Clinicopathological features of colloid adenocarcinoma of the lung: A report of six cases.
OBJECTIVES
Colloid adenocarcinoma of the lung (CA) is a rare neoplasm that is associated with abundant mucin, which destroys alveoli. We evaluated the clinicopathological features of CA.


METHODS
A total of 4,648 patients underwent surgical resection of primary lung cancer at our institution from 2002 to 2014. We analyzed the clinicopathological features of CA in six (0.13%) of these patients.


RESULTS
All patients were asymptomatic. The median age was 60.5 years. The median tumor size was 2.4 cm. All tumors appeared as solitary solid nodules on computed tomography (CT). Four of the six showed intense (18) F-fluorodeoxyglucose positron emission tomography ((18) F-FDG-PET) accumulation, and the remaining two showed weak (18) F-FDG accumulation. All patients underwent lobectomy with systematic lymph node dissection. Histologically, CAs presented with various degrees of a non-mucinous component in addition to abundant mucin. Only one patient with pN2 had recurrence.


CONCLUSIONS
On CT, CA appears a solitary solid nodule. Further, FDG-PET findings present various (18) F-FDG accumulations. Lobectomy with systematic lymph node dissection is an appropriate procedure in view of lymph node metastasis. Since the definitive diagnosis of CA of the lung is difficult, further immunohistochemical and genetic analyses are needed. J. Surg. Oncol. 2016;114:211-215. © 2016 Wiley Periodicals, Inc.
['Masai|Kyohei|K|', 'Sakurai|Hiroyuki|H|', 'Suzuki|Shigeki|S|', 'Asakura|Keisuke|K|', 'Nakagawa|Kazuo|K|', 'Watanabe|Shun-Ichi|S|']
D002288:Adenocarcinoma, Mucinous D000328:Adult D000368:Aged D005260:Female D019788:Fluorodeoxyglucose F18 D006801:Humans D007150:Immunohistochemistry D008175:Lung Neoplasms D008197:Lymph Node Excision D008297:Male D008875:Middle Aged D011013:Pneumonectomy D049268:Positron-Emission Tomography D014057:Tomography, X-Ray Computed
colloid adenocarcinoma mucin lung cancer positron-emission tomography