Hair growth-promoting effect of Carthamus tinctorius floret extract.
The florets of Carthamus tinctorius L. have traditionally been used for hair growth promotion. This study aimed to examine the potential of hydroxysafflor yellow A-rich C. tinctorius extract (CTE) on hair growth both in vitro and in vivo. The effect of CTE on cell proliferation and hair growth-associated gene expression in dermal papilla cells and keratinocytes (HaCaT) was determined. In addition, hair follicles from mouse neonates were isolated and cultured in media supplemented with CTE. Moreover, CTE was applied topically on the hair-shaved skin of female C57BL/6 mice, and the histological profile of the skin was investigated. C. tinctorius floret ethanolic extract promoted the proliferation of both dermal papilla cells and HaCaT and significantly stimulated hair growth-promoting genes, including vascular endothelial growth factor and keratinocyte growth factor. In contrast, CTE suppressed the expression of transforming growth factor-β1 that is the hair loss-related gene. Furthermore, CTE treatment resulted in a significant increase in the length of cultured hair follicles and stimulated the growth of hair with local effects in mice. The results provided the preclinical data to support the potential use of CTE as a hair growth-promoting agent.
['Junlatat|Jintana|J|', 'Sripanidkulchai|Bungorn|B|']
D000818:Animals D031187:Carthamus tinctorius D002460:Cell Line D049109:Cell Proliferation D020405:Dermis D005260:Female D051523:Fibroblast Growth Factor 7 D015870:Gene Expression D006197:Hair D018859:Hair Follicle D006801:Humans D015603:Keratinocytes D051379:Mice D008810:Mice, Inbred C57BL D008813:Mice, Inbred ICR D010936:Plant Extracts D053773:Transforming Growth Factor beta1 D042461:Vascular Endothelial Growth Factor A
Carthamus tinctorius hair growth vascular endothelial growth factor keratinocyte growth factor transforming growth factor-β1