Transcriptomic effects of the non-steroidal anti-inflammatory drug Ibuprofen in the marine bivalve Mytilus galloprovincialis Lam.
The transcriptomic effects of Ibuprofen (IBU) in the digestive gland tissue of Mytilus galloprovincialis Lam. specimens exposed at low environmental concentrations (250 ng L(-1)) are presented. Using a 1.7 K feature cDNA microarray along with linear models and empirical Bayes statistical methods 225 differentially expressed genes were identified in mussels treated with IBU across a 15-day period. Transcriptional dynamics were typical of an adaptive response with a peak of gene expression change at day-7 (177 features, representing about 11% of sequences available for analysis) and an almost full recovery at the end of the exposure period. Functional genomics by means of Gene Ontology term analysis unraveled typical mussel stress responses i.e. aminoglycan (chitin) metabolic processes but also more specific effects such as the regulation of NF-κB transcription factor activity.
['Maria|Vera L|VL|', 'Amorim|Mónica J B|MJ|', 'Bebianno|Maria João|MJ|', 'Dondero|Francesco|F|']
D000818:Animals D000894:Anti-Inflammatory Agents, Non-Steroidal D001499:Bayes Theorem D005786:Gene Expression Regulation D007052:Ibuprofen D049878:Mytilus D016328:NF-kappa B D059467:Transcriptome D014874:Water Pollutants, Chemical
Gene expression NF-κB Chitinase GM2 ganglioside activator Inflammation Innate immunity Mitochondrion