Comparison of Fractional Exhaled Nitric Oxide in Elderly Patients with Asthma-chronic Obstructive Pulmonary Disease Overlap and Other Airway Inflammatory Diseases.
The exact role of fractional exhaled nitric oxide (FeNO) in older patients with chronic inflammatory diseases including asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) remains unclear. This study aimed to investigate the differences in FeNO levels of elderly patients with ACO, asthma, COPD, and chronic cough. We conducted a retrospective study analysing the data of stable outpatients from Pulmonary Department of the Second Clinical College, Jinan University. All participants (Age≥55 years) were divided into the ACO group (n=19), asthma group (n=16), COPD group (n=25), and chronic cough group (n=22). The clinical data such as peripheral eosinophil counts, serum high sensitivity C-reactive protein (hs-CRP), FeNO, and spirometry was collected, and the correlations between FeNO levels and systemic markers or spirometric indices were analyzed. Patients with ACO and asthma had significantly elevated FeNO levels (37.7±16.5, and 36.3±17.7 ppb) compared with COPD, and chronic cough patients (21.9±10.3, and 16.1±8.8 ppb). The FeNO levels were negatively associated with forced expiratory volume in 1 second (FEV1, p=0.003), FEV1% predicted (p=0.012), and FEV1/forced vital capacity (FVC, p=0.002) in all groups. However, there were no significant correlation between FeNO levels and FVC, peripheral eosinophil counts, or serum hs-CRP (p>0.05). Elderly patients with ACO have higher levels of FeNO, when compared with patients with COPD or chronic cough. These findings suggest that FeNO measurement may provide an important implication for the etiological diagnosis of ACO in the elderly patients.
['Shi|Fei|F|', 'Qiu|Chen|C|', 'Yu|Jie|J|', 'Yang|Ying|Y|', 'Li|Binbin|B|', 'Feng|Mengjie|M|', 'Zhang|Ting|T|', 'Liu|Wenwen|W|']
D000368:Aged D000369:Aged, 80 and over D001249:Asthma D002097:C-Reactive Protein D002452:Cell Count D004804:Eosinophils D045853:Exhalation D005260:Female D006801:Humans D007249:Inflammation D008297:Male D008875:Middle Aged D009569:Nitric Oxide D029424:Pulmonary Disease, Chronic Obstructive D012140:Respiratory Tract Diseases D012189:Retrospective Studies D013147:Spirometry
Nitric oxide Elderly Asthma-chronic obstructive pulmonary disease overlap Asthma