Serum TNF-α, erythrocyte sedimentation rate and IL-6 are more valuable biomarkers for assisted diagnosis of extremity chronic osteomyelitis.
AIM
This study aimed to investigate the values of preoperative serum levels of white blood cell, erythrocyte sedimentation rate (ESR), C-reactive protein, procalcitonin, IL-6, TNF-α and serum amyloid A for diagnosis of chronic osteomyelitis (COM) in Chinese patients.


METHODS
All 586 eligible patients were included for analysis.


RESULTS
Outcomes revealed that positive ratios of TNF-α, ESR and IL-6 lied in top three. Taken predicted probability and detection cost into consideration, combination of ESR, IL-6 and TNF-α might be the optimal model due to its high predicted probability for COM (91.02%) with an acceptable cost (CN¥161).


CONCLUSION
Combination of preoperative serum TNF-α, ESR and IL-6 can help a reliable predication of COM.
['Jiang|Nan|N|', 'Qin|Cheng-He|CH|', 'Hou|Yi-Long|YL|', 'Yao|Zi-Long|ZL|', 'Yu|Bin|B|']
TNF-α IL-6 chronic osteomyelitis diagnostic values inflammatory biomarkers retrospective analysis