Fatty acids found in dairy, protein and unsaturated fatty acids are associated with risk of pancreatic cancer in a case-control study.
Although many studies have investigated meat and total fat in relation to pancreatic cancer risk, few have investigated dairy, fish and specific fatty acids (FAs). We evaluated the association between intake of meat, fish, dairy, specific FAs and related nutrients and pancreatic cancer. In our American-based Mayo Clinic case-control study 384 cases and 983 controls frequency matched on recruitment age, race, sex and residence area (Minnesota, Wisconsin or Iowa, USA) between 2004 and 2009. All subjects provided demographic information and completed 144-item food frequency questionnaire. Logistic regression-calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) were adjusted for age, sex, cigarette smoking, body mass index and diabetes mellitus. Significant inverse association (trend p-value < 0.05) between pancreatic cancer and the groupings (highest vs. lowest consumption quintile OR [95% CI]) was as follows: meat replacement (0.67 [0.43-1.02]), total protein (0.58 [0.39-0.86]), vitamin B12 (0.67 [0.44, 1.01]), zinc (0.48 [0.32, 0.71]), phosphorus (0.62 [0.41, 0.93]), vitamin E (0.51 [0.33, 0.78]), polyunsaturated FAs (0.64 [0.42, 0.98]) and linoleic acid (FA 18:2) (0.62 [0.40-0.95]). Increased risk associations were observed for saturated FAs (1.48 [0.97-2.23]), butyric acid (FA 4:0) (1.77 [1.19-2.64]), caproic acid (FA 6:0) (2.15 [1.42-3.27]), caprylic acid (FA 8:0) (1.87 [1.27-2.76]) and capric acid (FA 10:0) (1.83 [1.23-2.74]). Our study suggests that eating a diet high in total protein and certain unsaturated FAs is associated with decreased risk of developing pancreatic cancer in a dose-dependent manner, whereas fats found in dairy increase risk.
['Jansen|Rick J|RJ|', 'Robinson|Dennis P|DP|', 'Frank|Ryan D|RD|', 'Anderson|Kristin E|KE|', 'Bamlet|William R|WR|', 'Oberg|Ann L|AL|', 'Rabe|Kari G|KG|', 'Olson|Janet E|JE|', 'Sinha|Rashmi|R|', 'Petersen|Gloria M|GM|', 'Stolzenberg-Solomon|Rachael Z|RZ|']
D000368:Aged D016022:Case-Control Studies D003611:Dairy Products D004032:Diet D004041:Dietary Fats D005231:Fatty Acids, Unsaturated D005247:Feeding Behavior D005260:Female D006801:Humans D008297:Male D008460:Meat D010190:Pancreatic Neoplasms D011506:Proteins D012307:Risk Factors D011795:Surveys and Questionnaires
pancreatic cancer case-control study dairy consumption fat consumption meat consumption