Chitosan/glycosaminoglycan scaffolds for skin reparation.
Burns and chronic wounds, often related to chronic diseases (as diabetes and cancer), are challenging lesions, difficult to heal. The prompt and full reconstitution of a functional skin is at the basis of the development of biopolymer-based scaffolds, representing a 3D substrate mimicking the dermal extracellular matrix. Aim of the work was to develop scaffolds intended for skin regeneration, according to: fabrication by electrospinning from aqueous polysaccharide solutions; prompt and easy treatment to obtain scaffolds insoluble in aqueous fluids; best performance in supporting wound healing. Three formulations were tested, based on chitosan (CH) and pullulan (P), associated with glycosaminoglycans (chondroitin sulfate - CS or hyaluronic acid - HA). A multidisciplinary approach has been used: chemico-physical characterization and preclinical evaluation allowed to obtain integrated information. This supports that CS gives distinctive properties and optimal features to the scaffold structure for promoting cell proliferation leading tissue reparation towards a complete skin restore.
['Sandri|Giuseppina|G|', 'Rossi|Silvia|S|', 'Bonferoni|Maria Cristina|MC|', 'Miele|Dalila|D|', 'Faccendini|Angela|A|', 'Del Favero|Elena|E|', 'Di Cola|Emanuela|E|', 'Icaro Cornaglia|Antonia|A|', 'Boselli|Cinzia|C|', 'Luxbacher|Thomas|T|', 'Malavasi|Lorenzo|L|', "Cantu'|Laura|L|", 'Ferrari|Franca|F|']
D001672:Biocompatible Materials D002056:Burns D048271:Chitosan D002809:Chondroitin Sulfates D005936:Glucans D006801:Humans D006820:Hyaluronic Acid D017768:Skin, Artificial D023822:Tissue Engineering D054457:Tissue Scaffolds D014945:Wound Healing
Chitosan Glycosaminoglycans Electrospinning Chronic wound and burn healing In vitro and In vivo models