Altered morphology and function of the peripheral nociceptive system in the offspring of diabetic rats.
The aim of this study was to determine whether maternal diabetes induced by alloxan injection in the first gestational day of female Wistar rats interferes with the development of the nociceptive peripheral system of the offspring. Behavioral and histologic analysis was performed using the adult offspring of diabetic and control rats. It was found that the offspring of diabetic rats were more sensitive to thermal stimulation and showed an altered response to carrageenan-induced inflammatory hyperalgesia. The histological analysis showed an increased proportion of nociceptive neurons, while the population of non-nociceptive myelinated neurons was reduced. Therefore, exposition to hyperglycemia and/or hyperinsulinemia in uterus, caused by a diabetic mother, might result in altered nociceptive sensations in the offspring throughout life.
['Campos Lima|Taís|T|', 'Lemes|Júlia Borges Paes|JBP|', 'Capop|Tauane Franco Pinheiro Alves|TFPA|', 'de Lima|Lorena Borges|LB|', 'Monteiro da Cruz Lotufo|Celina|C|https://orcid.org/0000-0002-7199-3498']
D000818:Animals D002351:Carrageenan D003921:Diabetes Mellitus, Experimental D003929:Diabetic Neuropathies D005260:Female D005727:Ganglia, Spinal D006358:Hot Temperature D006930:Hyperalgesia D008297:Male D009474:Neurons D059225:Nociception D009619:Nociceptors D010147:Pain Measurement D010812:Physical Stimulation D011247:Pregnancy D051381:Rats D017208:Rats, Wistar
nociception maternal diabetes development dorsal root ganglia pain sensory neurons