Glucose-6-phosphate dehydrogenase deficiency: an unusual cause of acute jaundice after paracetamol overdose.
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the commonest human enzyme defect causing haemolytic anaemia after exposure to specific triggers. Paracetamol-induced haemolysis in G6PD deficiency is a rare complication and mostly reported in children. We report the first case (to the best of our knowledge) of acute jaundice without overt clinical features of a haemolytic crisis, in an otherwise healthy adult female following paracetamol overdose, due to previously undiagnosed G6PD deficiency. It is important that clinicians consider this condition when a patient presents following a paracetamol overdose with significant and disproportionate jaundice, without transaminitis or coagulopathy.
['Phillpotts|Simon|S|', 'Tash|Elliot|E|', 'Sen|Sambit|S|']
D000082:Acetaminophen D000208:Acute Disease D000328:Adult D058633:Antipyretics D062787:Drug Overdose D005260:Female D005955:Glucosephosphate Dehydrogenase Deficiency D006801:Humans D007565:Jaundice
Glucose-6-phosphate dehydrogenase paracetamol anaemia haemolysis Glucose-6-phosphate deficiency