Vitamin D supplements in chronic kidney disease.
Chronic kidney disease (CKD) is a significant public health problem and Vitamin D deficiency is prevalent in CKD and might be associated with calcium and phosphate metabolism, cardiovascular disease, infections as well as the progress of kidney dysfunction. Emerging evidence implies that Vitamin D supplements may be of benefit to CKD. Based on existing laboratory and clinical evidence, this review intends to discuss the effectiveness of Vitamin D supplements and controversy in clinical practice. The effect of Vitamin D in CKD patients is summarized in detail from CKD-mineral bone disease, the progression of renal function, cardiovascular events and immune system. Considerable disputes exist for the Vitamin D supplements in CKD, and a growing amount of experimental evidence and some clinical evidence are now gathering from in vitro, animal and epidemiological studies.
['Zhu|Nan|N|', 'Wang|Jialin|J|', 'Gu|Lijie|L|', 'Wang|Ling|L|', 'Yuan|Weijie|W|']
D000818:Animals D002318:Cardiovascular Diseases D019587:Dietary Supplements D004195:Disease Models, Animal D018450:Disease Progression D005260:Female D006801:Humans D008297:Male D051379:Mice D018345:Mice, Knockout D011379:Prognosis D016032:Randomized Controlled Trials as Topic D051436:Renal Insufficiency, Chronic D018570:Risk Assessment D016896:Treatment Outcome D014807:Vitamin D D014808:Vitamin D Deficiency
Vitamin D Vitamin D supplements CKD Vitamin D deficiency Vitamin D analogs