Five challenges in evolution and infectious diseases.
Evolution is a key aspect of the biology of many pathogens, driving processes ranging from immune escape to changes in virulence. Because evolution is inherently subject to feedbacks, and because pathogen evolution plays out at scales ranging from within-host to between-host and beyond, evolutionary questions provide special challenges to the modelling community. In this article, we provide an overview of five challenges in modelling the evolution of pathogens and their hosts, and point to areas for development, focussing in particular on the issue of linking theory and data.
['Metcalf|C J E|CJ|', 'Birger|R B|RB|', 'Funk|S|S|', 'Kouyos|R D|RD|', 'Lloyd-Smith|J O|JO|', 'Jansen|V A A|VA|']
D044822:Biodiversity D005075:Biological Evolution D060085:Coinfection D003141:Communicable Diseases D054884:Host-Pathogen Interactions D006801:Humans D012641:Selection, Genetic D014774:Virulence
Coinfection Diversity Fitness Genetic systems R0