Cognitive rehabilitation training in patients with brain tumor-related epilepsy and cognitive deficits: a pilot study.
The aim of this pilot observational study was to evaluate effect of cognitive rehabilitation training (RehabTr) on cognitive performances in patients with brain tumor-related epilepsy (BTRE) and cognitive disturbances. Medical inclusion criteria: patients (M/F) ≥ 18 years ≤ 75 with symptomatic seizures due to primary brain tumors or brain metastases in stable treatment with antiepileptic drugs; previous surgical resection or biopsy; >70 Karnofsky Performance Status; stable oncological disease. Eligible patients recruited from 100 consecutive patients with BTRE at first visit to our Center from 2011 to 2012. All recruited patients were administered battery of neuropsychological tests exploring various cognitive domains. Patients considered to have a neuropsychological deficit were those with at least one test score for a given domain indicative of impairment. Thirty patients out of 100 showed cognitive deficits, and were offered participation in RehabTr, of which 16 accepted (5 low grade glioma, 4 high grade glioma, 2 glioblastoma, 2 meningioma and 3 metastases) and 14 declined for various reasons. The RehabTr consisted of one weekly individual session of 1 h, for a total of 10 weeks, carried out by a trained psychologist. The functions trained were: memory, attention, visuo-spatial functions, language and reasoning by means of Training NeuroPsicologico (TNP(®)) software. To evaluate the effect of the RehabTr, the same battery of tests was administered directly after cognitive rehabilitation (T1), and at six-month follow-up (T2). Statistical analysis with Student T test for paired data showed that short-term verbal memory, episodic memory, fluency and long term visuo-spatial memory improved immediately after the T1 and remained stable at T2. At final follow-up all patients showed an improvement in at least one domain that had been lower than normal at baseline. Our results demonstrated a positive effect of rehabilitative training at different times, and, for these reasons, should encourage future research in this area with large, randomized clinical trials that evaluate the impact of a cognitive rehabilitation in patients with BTRE and cognitive deficits.
['Maschio|Marta|M|', 'Dinapoli|Loredana|L|', 'Fabi|Alessandra|A|', 'Giannarelli|Diana|D|', 'Cantelmi|Tonino|T|']
D000328:Adult D000368:Aged D001932:Brain Neoplasms D003072:Cognition Disorders D015928:Cognitive Behavioral Therapy D004827:Epilepsy D005260:Female D006801:Humans D017567:Karnofsky Performance Status D008297:Male D008609:Mental Status Schedule D008875:Middle Aged D009483:Neuropsychological Tests D010865:Pilot Projects D012189:Retrospective Studies D016896:Treatment Outcome D055815:Young Adult
Cognitive rehabilitation Brain tumor-related epilepsy Cognitive deficits Brain tumor Antiepileptic drugs