Camptothecin encapsulated into functionalized MCM-41: In vitro release study, cytotoxicity and kinetics.
The application of MCM-41 functionalized by 12-tungstophosphoric acid (TPA) as drug carrier for cancer treatment was studied by loading of camptothecin (CPT). In-vitro controlled release study of CPT in Simulated Body Fluid (pH 7.4, 37 °C) was carried out under stirring as well as static conditions. The systems were also evaluated on cancer cells (HepG2) and the carriers are found to be non-toxic to the cancer cells. In order to see the influence of inorganic moiety on release rate of drug, study was also carried out with CPT loaded unfunctionalized MCM-41. A detailed study on release kinetics and release mechanism using First Order Release Kinetic Model, Higuchi Model, Koresmeyer-Pepps Model and Extended kinetic model was also carried out.
['Solanki|Priyanka|P|', 'Patel|Shweta|S|', 'Devkar|Ranjitsinh|R|', 'Patel|Anjali|A|']
D002166:Camptothecin D016923:Cell Death D004339:Drug Compounding D065546:Drug Liberation D056945:Hep G2 Cells D006801:Humans D007700:Kinetics D012822:Silicon Dioxide D013818:Thermogravimetry D014961:X-Ray Diffraction
Camptothecin MCM-41 In vitro release Kinetics 12-tungstophosphoric acid MTT assay