Burden of lymphoma in China, 2006-2016: an analysis of the Global Burden of Disease Study 2016.
BACKGROUND
The accurate information about lymphoma burden at national and provincial levels remains unknown in China.


METHODS
Following the general analytical strategy used in GBD 2016, the age-, sex-, and province-specific incidence, mortality, and prevalence of lymphoma in China were analyzed. Trends in the incidence, mortality, prevalence, and disability-adjusted life years (DALYs) due to Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL) were assessed from 2006 to 2016.


RESULTS
It was estimated that there were 75,400 new cases and 40,500 deaths of lymphoma in 2016 in China, of which 6900 new cases and 2900 deaths were due to HL, while 68,500 new cases and 37,600 deaths were due to NHL. The age-standardized incidence rate (ASIR), mortality rate (ASMR), and prevalence rate (ASPR) per 100,000 were 0.46, 0.19, and 1.75 for HL, and 4.29, 2.45, and 14.9 for NHL, respectively. An upward trend with age in incidence and mortality was observed. Males had higher incidence and mortality rates than females in all age groups. Sociodemographic index had a correlation with the ASIR (r = 0.75), ASMR (r = - 0.74), ASPR (r = 0.84), and age-standardized DALYs (r = - 0.75) of HL, as well as with the ASIR (r = 0.80), ASPR (r = 0.83), and age-standardized DALYs (r = - 0.33) of NHL. From 2006 to 2016, the age-standardized DALYs of HL decreased significantly, while the age-standardized DALYs of NHL increased from 2006 to 2013 and remained stable from 2013 to 2016.


CONCLUSIONS
The burden of lymphoma in China showed unexpected patterns varied by sex, age, and provinces, with an increased trend of NHL and a decreased trend of HL from 2006 to 2016.
['Liu|Weiping|W|', 'Liu|Jiangmei|J|', 'Song|Yuqin|Y|', 'Zeng|Xinying|X|', 'Wang|Xiaopei|X|', 'Mi|Lan|L|', 'Cai|Cai|C|', 'Wang|Lijun|L|', 'Ma|Jun|J|', 'Zhu|Jun|J|0000-0003-3479-2547', '|||', '|||']
D000293:Adolescent D000328:Adult D000367:Age Factors D000368:Aged D000369:Aged, 80 and over D002648:Child D002675:Child, Preschool D002681:China D005260:Female D005500:Follow-Up Studies D000071219:Global Burden of Disease D006801:Humans D015994:Incidence D007223:Infant D007231:Infant, Newborn D008223:Lymphoma D008297:Male D008875:Middle Aged D015995:Prevalence D011379:Prognosis D012307:Risk Factors D012737:Sex Factors D015996:Survival Rate D013997:Time Factors D055815:Young Adult
Lymphoma Incidence Mortality Prevalence Non-Hodgkin Epidemiology Hodgkin’s disease