Investigating the structure-function relationship using Goldmann V standard automated perimetry where glaucomatous damage is advanced.
PURPOSE
To investigate if the structure-function relationship between circumpapillary retinal nerve fibre layer (cpRNFL) thickness and visual field (VF) thresholds is stronger when using the Goldmann V target rather than the Goldman III target where glaucomatous damage is advanced.


METHODS
Optical coherence tomography (OCT) and VF (Humphrey Field Analyzer 24-2 or 30-2) measurements with Goldmann III (SITA standard) and V (full-threshold) targets were carried out in 51 eyes of 51 patients with primary open angle glaucoma. The relationship between cpRNFL thicknesses in supero- and infero-temporal sectors, and VF sensitivity with the Goldmann III or V target was investigated.


RESULT
Visual field sensitivities (dB) both with the Goldmann III target and Goldmann V target showed a floor effect in the structure-function relationship against cpRNFL thickness, at approximately 60 μm. There was no significant relationship between visual field sensitivity measured with the Goldmann V target (dB scale: p = 0.12, 1/Lambert scale: p = 0.40; linear mixed models) and cpRNFL thickness, when corresponding visual field sensitivity, measured with the Goldmann III target, was <20 dB.


CONCLUSION
There was no improvement in the structure-function relationship using the Goldmann V target (full-threshold), compared to using the Goldmann III target (SITA standard), where glaucomatous damage was advanced.
['Yanagisawa|Mieko|M|', 'Murata|Hiroshi|H|', 'Matsuura|Masato|M|', 'Fujino|Yuri|Y|', 'Hirasawa|Kazunori|K|', 'Asaoka|Ryo|R|0000-0001-7182-1912']
D000368:Aged D003430:Cross-Sectional Studies D018450:Disease Progression D005260:Female D005902:Glaucoma, Open-Angle D006801:Humans D007429:Intraocular Pressure D008297:Male D008875:Middle Aged D009412:Nerve Fibers D009901:Optic Nerve Diseases D015203:Reproducibility of Results D012165:Retinal Ganglion Cells D041623:Tomography, Optical Coherence D058609:Visual Field Tests D014794:Visual Fields
optical coherence tomography glaucoma structure function relationship