Preliminary study of tissue concentrations of penicillin after local administration into the guttural pouches in four healthy horses.
BACKGROUND
Treatment of subclinical carriers of Streptococcus equi subsp. equi with a gelatine-penicillin formulation deposited in the guttural pouch has been empirically proposed, but data on local tissue penicillin concentrations after treatment are lacking.


METHODS
We analysed tissue levels of penicillin after administration into the guttural pouches of four healthy horses. Two horses received local treatment with gelatine-penicillin and two horses received local treatment with an intramammary formulation of penicillin. Tissues were harvested for analysis either 12 or 24 h later.


CONCLUSION
Results indicate that local treatment may be effective, but more research on optimal drug formulations in a larger sample size is warranted.
['Kendall|A|A|', 'Mayhew|I G|IG|', 'Petrovski|K|K|']
D000825:Animal Structures D000818:Animals D000900:Anti-Bacterial Agents D002353:Carrier State D004724:Endoscopy D006734:Horse Diseases D006736:Horses D010406:Penicillins D013290:Streptococcal Infections D018502:Streptococcus equi D014018:Tissue Distribution
penicillin guttural pouch horses Streptococcus local treatment