Gender dependent association of 25-hydroxyvitamin D and circulating leptin in saudi subjects: influence of dyslipidemia.
BACKGROUND AND OBJECTIVE
Leptin and vitamin D play an important role in obesity development and metabolic effects; however, the association between leptin and vitamin D is not well studied in Saudi subjects. We aimed to examine gender dependent association between serum leptin and 25-OH-VitD in adult Saudi subjects.


SUBJECTS AND METHODS
For this cross-sectional study in a cohort of 259 Saudi adults (100 male, age: 46.4 ± 0.9 yr [mean ± SD]; BMI: 27.8 ± 0.5 Kg/m(2)) and (159 female, age 46.5 ± 0.7 [mean ± SD]; BMI: 28.4 ± 0.4 Kg/m(2)) anthropometrics, fasting bloods, and biochemical data were collected. Serum leptin and 25-hydroxyvitamin D (vitamin D or 25-OH-VitD) were quantified using an enzyme-linked immunosorbent assay.


RESULTS
Circulating leptin and vitamin D levels were significantly higher in females compared to male (P<0.001 and P<0.01 respectively). Visceral adiposity index (VAI), triglycerides and total cholesterol were significantly higher (P<0.05, P<0.001, and P<0.05, respectively) while HDL-cholesterol were lower (P<0.001) in male compared to female subjects. In males, vitamin D levels were positively associated with leptin (r = 0.196, P<0.05).


CONCLUSION
Vitamin D was positively associated with serum leptin in male Saudi subjects. Additionally, male subjects were found to be dyslipidemic, which might be a responsible factor for this discordant association between vitamin D and leptin in Saudi population.
['Al-Daghri|Nasser M|NM|', 'Rahman|Shakilur|S|', 'Amer|Osama E|OE|', 'Al-Attas|Omar S|OS|', 'McTernan|Philip G|PG|', 'Alokail|Majed S|MS|']
Leptin Saudi subjects dyslipidemia vitamin D