Universal SARS-CoV-2 polymerase chain reaction screening and assisted reproductive technology in a coronavirus disease 2019 pandemic epicenter: screening and cycle outcomes from a New York City fertility center.
OBJECTIVE
To evaluate the prevalence of coronavirus disease 2019 (COVID-19) and efficacy of a universal screening program in patients undergoing controlled ovarian stimulation (COS).


DESIGN
Single-center retrospective cohort study.


SETTING
Academic fertility center in an epicenter of the COVID-19 pandemic.


PATIENT(S)
All patients undergoing COS from June 17, 2019, to February 28, 2021.


INTERVENTION(S)
Universal COVID-19 screening starting June 17, 2020, with SARS-CoV-2 polymerase chain reaction testing within 5 days of oocyte retrieval, patient-reported symptom screening, and temperature monitoring.


MAIN OUTCOMES MEASURE(S)
The primary outcome was the number of positive COVID-19 cases in patients undergoing COS cycles. The secondary outcomes were cycle outcomes compared with before COVID-19 COS cycles, adverse outcomes in COVID-canceled cycles, and center-specific COVID-19 detection rates compared with New York City cases.


RESULT(S)
From June 17, 2020, to February 28, 2021, 1,696 COS cycles were initiated with only seven positive COVID-19 cases for an overall positivity rate of 0.4%. When compared with before COVID cycles from June 17, 2019, to February 28, 2020, the volume of COS cycles were higher, while the overall cycle cancelation rate was lower during COVID-19. Cycle outcomes including oocyte yield and blast utilization rates were unchanged from pre-COVID cycles. Cases of COVID-19, while very low, occurred more frequently during surges in New York City rates.


CONCLUSION(S)
Assisted reproductive technology can be performed during the COVID-19 pandemic utilizing frequent universal screening and safe practices with low SARS-CoV-2 positivity, low cycle cancelation rates, and positive patient outcomes.
['Shaw|Jacquelyn|J|', 'Tozour|Jessica|J|', 'Blakemore|Jennifer K|JK|', 'Grifo|James|J|']
D000328:Adult D000086382:COVID-19 D015331:Cohort Studies D005260:Female D046910:Fertile Period D000080104:Fertility Clinics D006801:Humans D008403:Mass Screening D009519:New York City D058873:Pandemics D016133:Polymerase Chain Reaction D027724:Reproductive Techniques, Assisted D012189:Retrospective Studies D000086402:SARS-CoV-2
COVID-19 universal screening controlled ovarian stimulation