Randomized controlled trial of sodium phosphate tablets vs polyethylene glycol solution for colonoscopy bowel cleansing.
AIM
To compare efficacy, patient compliance, acceptability, satisfaction, safety, and adenoma detection rate of sodium phosphate tablets (NaP, CLICOLON(TM)) to a standard 4 L polyethylene glycol (PEG) solution for bowel cleansing for adults undergoing colonoscopy.


METHODS
In this multicenter, randomized, prospective, investigator-blind study, the relatively young (19-60 years) healthy outpatients without comorbidity were randomly assigned to one of two arms. All colonoscopy were scheduled in the morning. The NaP group was asked to take 4 tablets, 5 times the evening before and 4 tablets, 3 times early on the morning of the colonoscopy. The PEG group was asked to ingest 2 L of solution the evening before and 2 L early in the morning of the procedure. Adequacy of bowel preparation was scored using the Boston bowel preparation scale.


RESULTS
No significant differences were observed between the NaP group (n = 158) and PEG group (n = 162) in bowel cleansing quality (adequate preparation 93.0% vs 92.6%, P = 0.877), patient compliance (P = 0.228), overall adverse events (63.3% vs 69.1%, P = 0.269), or adenoma detection rate (34.8% vs 35.2%, P = 0.944). Patient acceptability, satisfaction, and patient rating of taste were higher in the NaP group than in the PEG group (P < 0.001).


CONCLUSION
NaP tablets, compared with PEG solution, produced equivalent colon cleansing, did not cause more side effects, and had better patient acceptability and satisfaction in the relatively young (age < 60 years) healthy individuals without comorbidity. An oral tablet formulation could make bowel preparation less burdensome, resulting in greater patient participation in screening programs.
['Jung|Yoon Suk|YS|', 'Lee|Chang Kyun|CK|', 'Kim|Hyo Jong|HJ|', 'Eun|Chang Soo|CS|', 'Han|Dong Soo|DS|', 'Park|Dong Il|DI|']
D018256:Adenomatous Polyps D000284:Administration, Oral D000328:Adult D002400:Cathartics D003111:Colonic Polyps D003113:Colonoscopy D015179:Colorectal Neoplasms D004334:Drug Administration Schedule D005260:Female D006785:Hospitals, University D006801:Humans D008297:Male D008875:Middle Aged D010349:Patient Compliance D017060:Patient Satisfaction D019999:Pharmaceutical Solutions D010710:Phosphates D011092:Polyethylene Glycols D011237:Predictive Value of Tests D011446:Prospective Studies D056910:Republic of Korea D013607:Tablets D007507:Therapeutic Irrigation D013997:Time Factors
Sodium phosphate tablets Polyethylene glycol Colonoscopy Bowel preparation