Visible-Light-Promoted Iron-Catalyzed C(sp2 )-C(sp3 ) Kumada Cross-Coupling in Flow.
A continuous-flow, visible-light-promoted method has been developed to overcome the limitations of iron-catalyzed Kumada-Corriu cross-coupling reactions. A variety of strongly electron rich aryl chlorides, previously hardly reactive, could be efficiently coupled with aliphatic Grignard reagents at room temperature in high yields and within a few minutes' residence time, considerably enhancing the applicability of this iron-catalyzed reaction. The robustness of this protocol was demonstrated on a multigram scale, thus providing the potential for future pharmaceutical application.
['Wei|Xiao-Jing|XJ|', 'Abdiaj|Irini|I|', 'Sambiagio|Carlo|C|0000-0001-8536-103X', 'Li|Chenfei|C|', 'Zysman-Colman|Eli|E|', 'Alcázar|Jesús|J|', 'Noël|Timothy|T|0000-0002-3107-6927']
cross-coupling Kumada coupling flow chemistry iron catalysis photocatalysis