Immature platelet fraction predicts coagulopathy-related platelet consumption and mortality in patients with sepsis.
INTRODUCTION
The diagnostic and prognostic value of immature platelet fraction (IPF) in sepsis has not been determined. This study aimed to assess whether IPF is an early predictor of platelet decline due to coagulopathy and is associated with mortality in patients with sepsis.


MATERIALS AND METHODS
In total, 149 patients with a platelet count of ≥80×10(3)/μL on intensive care unit admission (101 with sepsis, 48 controls without sepsis) were prospectively evaluated. We measured IPF on admission and observed for development of subsequent platelet count decline (defined as a >30% decrease or <80×10(3)/μL) in 5days, and mortality at 28days. The absolute immature platelet count (AIPC) was calculated to evaluate thrombopoiesis.


RESULTS
Forty-seven patients with sepsis subsequently developed a decrease in platelet count. The IPF was highest in patients whose platelet count decreased, followed by patients without a decrease in platelet count and controls (median, 4.3% [3.1%-8.1%] vs. 3.7% [2.6%-4.6%] vs. 2.1% [1.6%-3.5%], respectively; P<0.0001). The AIPC was similar in patients with and without a decrease in platelet count (7.6 [4.2-10.0] vs. 5.9 [4.2-8.7]×10(3)/μL, respectively; P=0.32). Coagulation derangement was more severe in patients who did than did not subsequently develop a decreased platelet count. Cox regression and receiver operator characteristic curve analysis revealed that IPF was a strong independent predictor of mortality, with accuracy similar to a standard prognostic scoring system.


CONCLUSIONS
The admission IPF in septic patients predicts a subsequent decrease in platelet count, indicating platelet consumption with ongoing coagulopathy and risk of poor prognosis.
['Muronoi|Tomohiro|T|', 'Koyama|Kansuke|K|', 'Nunomiya|Shin|S|', 'Lefor|Alan Kawarai|AK|', 'Wada|Masahiko|M|', 'Koinuma|Toshitaka|T|', 'Shima|Jun|J|', 'Suzukawa|Masayuki|M|']
D000368:Aged D000369:Aged, 80 and over D001777:Blood Coagulation D001792:Blood Platelets D004211:Disseminated Intravascular Coagulation D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D010976:Platelet Count D011379:Prognosis D016016:Proportional Hazards Models D011446:Prospective Studies D018805:Sepsis D013921:Thrombocytopenia D034061:Thrombopoiesis
Immature platelet fraction Mortality Sepsis Coagulopathy Disseminated intravascular coagulation Thrombocytopenia