Blood Pressure Trajectories From Childhood to Young Adulthood Associated With Cardiovascular Risk: Results From the 23-Year Longitudinal Georgia Stress and Heart Study.
The purpose of this study is to identify subgroups of individuals with similar trajectories in blood pressure (BP) from childhood to young adulthood and to determine the relationship of BP trajectories with carotid intima-media thickness (IMT) and left ventricular mass index (LVMI). BP was measured ≤16 times during a 23-year period in 683 participants from childhood to young adulthood. IMT and LVMI were measured in 551 participants and 546 participants, respectively. Using latent class models, 3 trajectory groups in BP from childhood to young adulthood were identified, including high-increasing, moderate-increasing, and low-increasing groups. We found that trajectory of systolic BP was a significant predictor of both IMT and LVMI with increased rate of growth in systolic BP associated with higher levels of IMT and LVMI (Pfor trend <0.001). Similar to the BP trajectory groups from childhood to young adulthood, 3 trajectory groups in BP during childhood (≤18 years) were identified, and participants in the high-increasing group had thicker IMT (P<0.001) and increased LVMI (P=0.043) in comparison with those in the low-increasing group. Results were similar for mid-BP trajectories but not for diastolic BP trajectories. Our results suggested that different BP trajectories exist from childhood to young adulthood, and the trajectories were independently associated with IMT and LVMI. We, for the first time, reported the association between systolic BP trajectories derived from childhood with subclinical cardiovascular risk in young adulthood, indicating that monitoring trajectories of BP from childhood may help identify a high cardiovascular risk population in early life.
['Hao|Guang|G|', 'Wang|Xiaoling|X|', 'Treiber|Frank A|FA|', 'Harshfield|Gregory|G|', 'Kapuku|Gaston|G|', 'Su|Shaoyong|S|']
D000293:Adolescent D017677:Age Distribution D000367:Age Factors D001794:Blood Pressure D002318:Cardiovascular Diseases D002339:Carotid Arteries D002648:Child D002675:Child, Preschool D005260:Female D005544:Forecasting D005845:Georgia D006801:Humans D015994:Incidence D008297:Male D015995:Prevalence D012189:Retrospective Studies D018570:Risk Assessment D012307:Risk Factors
adolescent adult atherosclerosis heart ventricles hypertension longitudinal study