Whole-Cell Models and Simulations in Molecular Detail.
Comprehensive data about the composition and structure of cellular components have enabled the construction of quantitative whole-cell models. While kinetic network-type models have been established, it is also becoming possible to build physical, molecular-level models of cellular environments. This review outlines challenges in constructing and simulating such models and discusses near- and long-term opportunities for developing physical whole-cell models that can connect molecular structure with biological function.
['Feig|Michael|M|', 'Sugita|Yuji|Y|']
D000818:Animals D003198:Computer Simulation D005057:Eukaryotic Cells D006801:Humans D008954:Models, Biological D056004:Molecular Dynamics Simulation D012984:Software
crowding molecular dynamics simulation network models protein structure systems biology