Regulatory B Cells and Its Role in Central Nervous System Inflammatory Demyelinating Diseases.
Regulatory B (Breg) cells represent a population of suppressor B cells that participate in immunomodulatory processes and inhibition of excessive inflammation. The regulatory function of Breg cells have been demonstrated in mice and human with inflammatory diseases, cancer, after transplantation, and particularly in autoinflammatory disorders. In order to suppress inflammation, Breg cells produce anti-inflammatory mediators, induce death ligand-mediated apoptosis, and regulate many kinds of immune cells such as suppressing the proliferation and differentiation of effector T cell and increasing the number of regulatory T cells. Central nervous system Inflammatory demyelinating diseases (CNS IDDs) are a heterogeneous group of disorders, which occur against the background of an acute or chronic inflammatory process. With the advent of monoclonal antibodies directed against B cells, breakthroughs have been made in the treatment of CNS IDDs. Therefore, the number and function of B cells in IDDs have attracted attention. Meanwhile, increasing number of studies have confirmed that Breg cells play a role in alleviating autoimmune diseases, and treatment with Breg cells has also been proposed as a new therapeutic direction. In this review, we focus on the understanding of the development and function of Breg cells and on the diversification of Breg cells in CNS IDDs.
['Ran|Zhou|Z|', 'Yue-Bei|Luo|L|', 'Qiu-Ming|Zeng|Z|', 'Huan|Yang|Y|']
D000818:Animals D060151:B-Lymphocytes, Regulatory D002454:Cell Differentiation D049109:Cell Proliferation D060833:Cellular Microenvironment D002490:Central Nervous System D020278:Demyelinating Autoimmune Diseases, CNS D006801:Humans D007167:Immunotherapy D008213:Lymphocyte Activation D010641:Phenotype D015398:Signal Transduction D013601:T-Lymphocytes
regulatory B cells central nervous system inflammatory demyelinating diseases multiple sclerosis neuromyelitis optica