Comprehensive assessment of prognosis after laparoscopic portoenterostomy for biliary atresia.
PURPOSE
Total bilirubin (T-bil) is used universally for monitoring post-portoenterostomy (PE) biliary atresia (BA) patients although other biochemical markers [BM; AST/ALT and platelet count (PC)] are also prognostic. We compared open PE (OPE) with laparoscopic PE (LPE) using T-bil, AST/ALT, and PC (3BM) as more comprehensive indicators of postoperative clinical status.


METHODS
Subjects were 31 PE cases (LPE: n = 17; OPE: n = 14). BA classification was type III (n = 16), type II (n = 1) in LPE and type III (n = 12), type I (n = 1), type II (n = 1) in OPE.


RESULTS
Mean ages and weights at PE were similar: 65.5 days, 4.4 kg (LPE) versus 69.3 days, 4.1 kg (OPE); and mean follow-up was 2.5 years for both LPE and OPE. Jaundice clearance (T-bil ≤1.2 mg/dL) was achieved in 16/17 (94.1 %) after LPE versus 10/14 (71.4 %) after OPE (p = NS), but 3BM were closer to normal after OPE. At the time of review, 13/17 LPE cases (76.5 %) were alive with native livers and 4/17 had received LTx (23.5 %) and 10/14 OPE cases (71.4 %) were alive with native livers and 4/14 had received LTx (28.6 %).


CONCLUSIONS
Although JC was better after LPE, 3BM were better after OPE. Further follow-up will prove the comprehensive prognostic value of 3BM.
['Nakamura|Hiroki|H|', 'Koga|Hiroyuki|H|', 'Cazares|Joel|J|', 'Okazaki|Tadaharu|T|', 'Lane|Geoffrey J|GJ|', 'Miyano|Go|G|', 'Okawada|Manabu|M|', 'Doi|Takashi|T|', 'Urao|Masahiko|M|', 'Yamataka|Atsuyuki|A|']
D001656:Biliary Atresia D015415:Biomarkers D005260:Female D006801:Humans D007223:Infant D010535:Laparoscopy D008297:Male D011171:Portoenterostomy, Hepatic D011183:Postoperative Complications D011379:Prognosis D016896:Treatment Outcome
Biliary atresia Biochemistry Laparoscopy Liver function