The influence of fasting and carbohydrate-enriched drink administration on body water amount and distribution: a volunteer randomized study.
BACKGROUND
Fasting prior to anesthesia is considered aspiration prophylaxis. However, prolonged food and drink restrictions may increase the risk of other complications. The aim of this study was to assess whether a carbohydrate-enriched drink (Nutricia™ preOp®), recommended by the enhanced recovery after surgery (ERAS) protocol, can improve body hydration in fasting healthy individuals.


METHODS
Measurements were done with the bioelectric impedance analysis with a Fresenius body composition monitor. Body composition, total body water, water distribution, and hemodynamic parameters were measured at the beginning of the study and after 10 h and 12 h of fasting. Patients fasted for 10 h and then were divided into two groups: the control (n = 40) and the pre-op group (n = 41). The pre-op group received 400 mL of Nutricia™ preOp®, as suggested in the ERAS guidance. The two-tailed Student's t test was used to compare two groups with normally distributed data and homogenous variances; if variances were heterogeneous, Welch's test was used. The Mann-Whitney U test was used to compare two groups with non-normal data distribution. p < 0.05 was considered statistically significant.


RESULTS
We found no significant differences between the control and pre-op groups regarding body water distribution and body composition. We did not observe significant losses in the total body water after fasting. Also, blood pressure was not affected by fasting.


CONCLUSION
We have proven that pre-op did not impact either body composition or body water.


TRIAL REGISTRATION
ClinicalTrials.gov , NCT04665349 . Registered on 11 December 2020-retrospectively registered.
['Kukliński|Jakub|J|https://orcid.org/0000-0002-1305-4767', 'Steckiewicz|Karol P|KP|http://orcid.org/0000-0002-5353-9849', 'Sekuła|Bartosz|B|https://orcid.org/0000-0001-5887-7436', 'Aszkiełowicz|Aleksander|A|https://orcid.org/0000-0002-6073-0588', 'Owczuk|Radosław|R|https://orcid.org/0000-0002-3441-5162']
Fasting Enhanced recovery after surgery (ERAS) Bioelectrical impedance analysis Total body water Dehydration Extracellular water Intracellular water Pre-op, Perioperative patient management