A novel role for TTK in homologous recombination: implications for breast cancer radiosensitivity.
Basal-like breast cancers have the highest rates of locoregional recurrence after radiation. By correlating gene expression with early locoregional recurrence, we nominate TTK protein kinase as a mediator of radioresistance. TTK inhibition radiosensitizes in vitro and in vivo through a novel mechanism of impaired homologous recombination and represents a promising translational strategy.
['Chandler|Benjamin C|BC|0000-0001-6963-9468', 'Speers|Corey|C|0000-0002-2362-2860']
TTK homologous recombination Breast cancer radiation sensitivity