The epidemiology of wrist fractures in older men: the Osteoporotic Fractures in Men (MrOS) study.
There is limited wrist fracture information on men. Our goal was to calculate frequency and identify risk factors for wrist fracture in the Osteoporotic Fractures in Men (MrOS) study. We confirmed that fracture history and certain medications are predictors, and identified novel predictors including markers of kidney function and physical performance.


INTRODUCTION
To calculate the incidence of wrist fractures and their risk factors in older community-dwelling men from the US Osteoporotic Fractures in Men (MrOS) study.


METHODS
Using triannual postcards, we identified incident wrist fractures (centrally confirmed by radiology) in men aged ≥ 65. Potential risk factors included the following: demographics, lifestyle, bone mineral density (BMD), selected medications, biomarkers, and physical function and performance measures. Both baseline and time-varying models were adjusted for age, race/ethnicity, MrOS geographic location, and competing mortality risks.


RESULTS
We observed 97 incident wrist fractures among 5875 men followed for an average of 10.8 years. The incidence of wrist fracture was 1.6 per 1000 person-years overall and ranged from 1.0 among men aged 65-69 to 2.4 among men age ≥ 80. Significant predictors included the following: fracture history after age 50 [hazard ratio (95% CI): 2.48 (1.65, 3.73)], high serum phosphate [1.25 (1.02, 1.53)], use of selective serotonin receptor inhibitor (SSRI) [3.60 (1.96, 6.63), decreased right arm BMD [0.49 (0.37, 0.65) per SD increase], and inability to perform the grip strength test [3.38 (1.24, 9.25)]. We did not find associations with factors commonly associated with wrist and other osteoporosis fractures like falls, diabetes, calcium and vitamin D intake, and alcohol intake.


CONCLUSIONS
Among these older, community-dwelling men, we confirmed that fracture history is a strong predictor of wrist fractures in men. Medications such as SSRIs and corticosteroids also play a role in wrist fracture risk. We identified novel risk factors including kidney function and the inability to perform the grip strength test.
['Wright|N C|NC|', 'Hooker|E R|ER|', 'Nielson|C M|CM|', 'Ensrud|K E|KE|', 'Harrison|S L|SL|', 'Orwoll|E S|ES|', 'Barrett-Connor|E|E|', '|||']
D000058:Accidental Falls D017677:Age Distribution D000367:Age Factors D000368:Aged D000369:Aged, 80 and over D006801:Humans D015994:Incidence D057187:Independent Living D008297:Male D058866:Osteoporotic Fractures D000076604:Physical Functional Performance D011446:Prospective Studies D012008:Recurrence D012307:Risk Factors D014481:United States D014954:Wrist Injuries
Epidemiology Wrist fracture Men Risk factors