Lean Women on Metformin and Oral Contraceptives for Polycystic Ovary Syndrome Demonstrate a Dehydrated Osteosarcopenic Phenotype: A Pilot Study.
Scarce data exist on the body composition of lean women with polycystic ovary syndrome (PCOS) on treatment with metformin and oral contraceptives (OCs). Thirty-four lean (body mass index 18.5-24.9 kg/m2) women (17 with PCOS on metformin and OCs treatment for six months and 17 controls) aged 18-40 years were assessed for body composition parameters (fat, muscle, glycogen, protein masses, bone masses, and body water compartments) and phase angles. PCOS patients demonstrated lower muscle, glycogen and protein masses (U = 60, p = 0.003), along with a lower bone mineral content and mass (U = 78, p = 0.021; U = 74, p = 0.014) than their healthy counterparts, while total and abdominal fat masses were similar between the two groups. PCOS patients also exhibited increased extracellular body water (U = 10, p < 0.001) and decreased intracellular water, compatible with low-grade inflammation and cellular dehydration. Key differences in body composition between women with PCOS and controls demonstrated an osteosarcopenic body composition phenotype in PCOS patients. A confirmation of these findings in larger studies may render osteosarcopenia management a targeted adjunct therapy in women with PCOS.
['Stefanaki|Charikleia|C|', 'Bacopoulou|Flora|F|0000-0003-1001-0926', 'Kandaraki|Eleni|E|', 'Boschiero|Dario|D|', 'Diamandi-Kandarakis|Evanthia|E|']
D000328:Adult D001823:Body Composition D003276:Contraceptives, Oral D005260:Female D006801:Humans D007004:Hypoglycemic Agents D008687:Metformin D010865:Pilot Projects D011085:Polycystic Ovary Syndrome D055815:Young Adult
metformin oral contraceptives polycystic ovary syndrome body composition pcos osteosarcopenia bio-impedance