Long non-coding RNA (lncRNA) MAGI2-AS3 inhibits breast cancer cell growth by targeting the Fas/FasL signalling pathway.
Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts shown to play important roles in tumourigenesis and tumour progression. Our study aimed to examine expression of the lncRNA MAGI2-AS3 in breast cancer and to explore its function in cancer cell growth. First, MAGI2-AS3 expression levels in clinical samples and cell lines were determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The functional significance of MAGI2-AS3 in cancer cell proliferation and apoptosis was then examined in vitro. Our results showed MAGI2-AS3 to be down-regulated in breast cancer tissues compared to normal adjacent tissues. Moreover, MAGI2-AS3 markedly inhibited breast cancer cell growth and increased expression of Fas and Fas ligand (FasL). In conclusion, our data suggest that MAGI2-AS3 expression is decreased in breast cancer and that MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. These results provide new insight into novel clinical treatments for breast cancer.
['Yang|Yong|Y|', 'Yang|Hong|H|', 'Xu|Miao|M|', 'Zhang|Haibin|H|', 'Sun|Mingtao|M|', 'Mu|Peng|P|', 'Dong|Tongbao|T|', 'Du|Shanmei|S|', 'Liu|Kui|K|']
D048868:Adaptor Proteins, Signal Transducing D017209:Apoptosis D001943:Breast Neoplasms D002352:Carrier Proteins D049109:Cell Proliferation D004268:DNA-Binding Proteins D015536:Down-Regulation D053222:Fas Ligand Protein D005260:Female D015870:Gene Expression D051528:Guanylate Kinases D006801:Humans D061986:MCF-7 Cells D008875:Middle Aged D058990:Molecular Targeted Therapy D062085:RNA, Long Noncoding D020133:Reverse Transcriptase Polymerase Chain Reaction D015398:Signal Transduction D012844:Sincalide D014157:Transcription Factors D014407:Tumor Cells, Cultured D019014:fas Receptor
lncRNA MAGI2-AS3 Breast cancer Fas/FasL Proliferation