Associations between tumor necrosis factor-α gene polymorphisms and the risk of Guillain-Barré syndrome and its subtypes: A systematic review and meta-analysis.
This meta-analysis aimed to assess the relationship between tumor necrosis factor-α (TNF-α) polymorphisms and Guillain-Barré syndrome (GBS) or its subtypes of acute inflammatory demyelinating polyneuropathy (AIDP), acute motor axonal neuropathy (AMAN), and acute motor-sensory axonal neuropathy (AMSAN). A total of six studies with 1013 cases and 1029 controls were included. Our pooled data indicated that TNF-α 308G/A polymorphism was significantly associated with GBS, AMAN, and AMSAN but not with AIDP; TNF-α 857C/T polymorphism was significantly associated with AMAN but not with GBS or AIDP. Besides, no association was found between TNF-α 238G/A and 863C/A polymorphisms and GBS or its subtypes.
['Liu|Ju|J|', 'Lian|Zhiyun|Z|', 'Chen|Hongxi|H|', 'Shi|Ziyan|Z|', 'Feng|Huiru|H|', 'Du|Qin|Q|', 'Zhang|Qin|Q|', 'Zhou|Hongyu|H|']
D020275:Guillain-Barre Syndrome D006801:Humans D020641:Polymorphism, Single Nucleotide D014409:Tumor Necrosis Factor-alpha
Tumor necrosis factor-α Polymorphism Guillain-Barré syndrome Meta-analysis Acute motor axonal neuropathy Genetic susceptibility