Metaplastic thymoma with myasthenia gravis presumably caused by an accumulation of intratumoral immature T cells: a case report.
Among human neoplasms, thymomas are well known for their association with paraneoplastic autoimmune diseases such as myasthenia gravis. However, regarding rare metaplastic thymoma, only one case of an association with myasthenia gravis has been reported. Here, we present the second case of a 44-year-old woman with metaplastic thymoma associated with myasthenia gravis. In metaplastic thymoma, intratumoral terminal deoxynucleotidyl transferase-positive T-cells (immature T-cells) are generally scarce, while they were abundant in the present case. We believe that these immature T-cells could be related to the occurrence of myasthenia gravis.
['Tajima|Shogo|S|', 'Yanagiya|Masahiro|M|', 'Sato|Masaaki|M|', 'Nakajima|Jun|J|', 'Fukayama|Masashi|M|']
D000328:Adult D014408:Biomarkers, Tumor D001706:Biopsy D002800:Cholinesterase Inhibitors D005260:Female D005938:Glucocorticoids D006801:Humans D007150:Immunohistochemistry D016246:Lymphocytes, Tumor-Infiltrating D008679:Metaplasia D009157:Myasthenia Gravis D013601:T-Lymphocytes D013934:Thymectomy D013945:Thymoma D013953:Thymus Neoplasms D014057:Tomography, X-Ray Computed D016896:Treatment Outcome
metaplastic thymoma myasthenia gravis immature T-cells Histology immunohistochemistry