Immunogenicity and safety of the diphtheria, pertussis, tetanus and inactivated poliovirus vaccine when co-administered with the human rotavirus vaccine (Rotarix) in healthy Japanese infants: a phase IV randomized study.
Rotavirus infections have been reported to account for 40-50% of all hospitalized acute gastroenteritis cases in young children (<5 years) in Japan. Since 2011, Rotarix containing the live attenuated human rotavirus RIX4414 strain (HRV) has been licensed in Japan for infants. Vaccination against rotavirus is optional in Japan whereas administration of diphtheria, pertussis, tetanus, and inactivated poliovirus (DPT-IPV) vaccine is part of the national routine immunization program. In this open-label, randomized, controlled, multicenter study, we evaluated the immunogenicity and safety of the DPT-IPV vaccine (Squarekids) administered concomitantly or staggered with the liquid HRV (Rotarix) vaccine in healthy Japanese infants. A total of 292 infants aged 6-12 weeks were randomly assigned to receive DPT-IPV vaccine and HRV vaccine co-administered (n = 147) or staggered (n = 145). Immune responses to DPT-IPV vaccine were evaluated by measuring the post-vaccination serum antibody titers/concentrations to each antigen at one month following the third dose of DPT-IPV vaccine. Seroprotection/seropositivity against each of the diphtheria, pertussis (pertussis toxin and filamentous hemagglutinin), tetanus, and poliovirus type 1, 2 and 3 antigens was 92.8% or higher in both groups. In terms of immunogenicity, DPT-IPV vaccine co-administered with HRV vaccine was shown to be non-inferior to DPT-IPV vaccine with a staggered administration. The safety profile was comparable in the two vaccine groups with no vaccine-related serious adverse events, no deaths and no cases of intussusception. These results support co-administration of HRV vaccine with DPT-IPV vaccine in Japan. ClinicalTrials.gov NCT02907216.
['Gillard|Paul|P|0000-0002-2841-0170', 'Tamura|Tsuyoshi|T|', 'Kuroki|Haruo|H|', 'Morikawa|Yoshiyuki|Y|', 'Moerman|Leentje|L|', 'Parra|Jose|J|', 'Kitamura|Yurina|Y|', 'Mihara|Kazuko|K|', 'Okamasa|Arisa|A|']
D000907:Antibodies, Bacterial D000914:Antibodies, Viral D015331:Cohort Studies D004165:Diphtheria D015721:Diphtheria-Tetanus-Pertussis Vaccine D005260:Female D006801:Humans D007117:Immunization, Secondary D000071497:Immunogenicity, Vaccine D007223:Infant D007564:Japan D008297:Male D011051:Poliomyelitis D011054:Poliovirus Vaccine, Inactivated D012400:Rotavirus Infections D022243:Rotavirus Vaccines D013742:Tetanus D014613:Vaccines, Attenuated D017778:Vaccines, Combined D014917:Whooping Cough
immunogenicity safety rotavirus vaccine infants Japan DPT-IPV vaccine co-administration