Acute DSS colitis alters EphB6 receptor expression in neurons of the spinal dorsal horn.
The ephrin family of receptors (Eph) and their ephrin ligands are involved in pain associated hyperalgesia, but the underlying mechanisms involved have not been fully elucidated. The EphB6 receptor is a distinctive member of the EphB subclass in that its kinase domain contains several alterations in the conserved amino acids and thus lacks catalytic activity. We sought to identify a role for EphB6 in inflammatory pain, with the murine dextran sulfate sodium (DSS) colitis model of inflammatory bowel disease (IBD). Colitis, induced with the administration of 4% (wt./vol.) DSS in the drinking water, significantly decreased EphB6 protein expression levels in neurons of the lower thoracic superficial layers of spinal dorsal horns, the location of neurons that receive the majority of nociceptive information from the colon, via the primary afferents. A shift towards increased EphB/ephrinB forward signaling, mediated by EphB6 down-regulation in neurons of the dorsal horn, may play a role in inflammatory pain caused by IBD.
['King|Dale E|DE|']
D000208:Acute Disease D000818:Animals D003092:Colitis D016264:Dextran Sulfate D004195:Disease Models, Animal D015536:Down-Regulation D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D020671:Posterior Horn Cells D036261:Receptor, EphB6
EphB6 Neuron Pain Inflammation