Quantification of myocardial blood flow by CZT-SPECT with motion correction and comparison with 15O-water PET.
BACKGROUND
We compared quantification of MBF and myocardial flow reserve (MFR) with a 99mTc-sestamibi CZT-SPECT to 15O-water PET.


METHODS
SPECT MBF for thirty patients in the WATERDAY study was re-analyzed by QPET software with motion correction and optimal placement of the arterial input function. 15O-water PET MBF was re-quantified using dedicated software. Inter-operator variability was assessed using repeatability coefficients (RPC).


RESULTS
Significant correlations were observed between global (r = 0.91, P < 0.001) and regional MBF (r = 0.86, P < 0.001) with SPECT compared to PET. Global MBF (rest 0.95 vs 1.05 ml/min/g, P = 0.07; stress 2.62 vs 2.68 mL/min/g, P = 0.17) and MFR (2.65 vs 2.75, P = 0.86) were similar between SPECT and PET. Rest (0.81 vs 0.98 mL/min/g, P = 0.03) and stress MBF (1.98 vs 2.61 mL/min/g, P = 0.01) in right coronary artery (RCA) were lower with SPECT compared to PET. However, MFR in the RCA territory was similar (2.54 vs 2.77, P = 0.21). The SPECT-PET RPC for global MBFs and MFR were 0.95 mL/min/g and 0.94, with inter-observer RPC of 0.59 mL/min/g and 0.74, respectively.


CONCLUSIONS
MBF and MFR derived from CZT-SPECT with motion correction and optimal placement of the arterial input function showed good agreement with 15O-water PET, as well as low inter-operator variability.
['Otaki|Yuka|Y|', 'Manabe|Osamu|O|', 'Miller|Robert J H|RJH|', 'Manrique|Alain|A|', 'Nganoa|Catherine|C|', 'Roth|Nathaniel|N|', 'Berman|Daniel S|DS|', 'Germano|Guido|G|', 'Slomka|Piotr J|PJ|', 'Agostini|Denis|D|']
Myocardial blood flow positron emission tomography single-photon emission computed tomography