IL7RA polymorphisms predict the CD4+ recovery in HIV patients on cART.
BACKGROUND
The IL7RA polymorphisms have recently been associated with CD4+ T-cell decline in untreated HIV-infected subjects and CD4+ T-cell recovery in patients on combination antiretroviral therapy (cART). The aim of this study was to evaluate whether IL7RA polymorphisms are associated with CD4+ T-cell recovery in HIV-infected patients on long-term cART.


STUDY DESIGN
We performed a retrospective study in 151 naïve cART patients with severe immunodeficiency (CD4+ counts ≤200 cells/mm(3) ). IL7RA polymorphisms' genotyping was performed using Sequenom's MassARRAY platform. The outcome variable was the time to achieve the first value of CD4+ count ≥500 cells/mm(3) during the follow-up.


RESULTS
Two different trends of CD4+ T-cell recovery were found in Kaplan-Meier analysis. During the first 48 months, 60 of 151 (39·7%) of the patients reached CD4+ T-cell values ≥500 cells/mm(3) , and no differences were observed between IL7RA genotypes. After the first 48 months of follow-up, 27 of 151 (17·8%) of the patients reached CD4+ T-cell values ≥500 cells/mm(3) , with a different pattern of CD4+ recovery depending on IL7RA genotype. Patients with rs10491434 TT genotype and rs6897932 TT genotype were more likely of achieving CD4+ value ≥500 cells/mm(3) than patients with rs10491434 CT/CC genotype (adjusted hazard ratio (aHR) = 3·59; P = 0·005) and patients with rs6897932 CC/CT genotype (aHR = 11·7; P < 0·001).


CONCLUSIONS
The IL7RA polymorphisms seem to be associated with CD4+ T-cell recovery in HIV-infected patients who started cART with severe immunodeficiency, in the second phase of CD4+ T-cell recovery after long-term cART.
['Guzmán-Fulgencio|María|M|', 'Berenguer|Juan|J|', 'Jiménez-Sousa|María Angeles|MA|', 'Micheloud|Dariela|D|', 'García-Álvarez|Mónica|M|', 'Bellón|José María|JM|', 'Aldámiz-Echevarría|Teresa|T|', 'García-Broncano|Pilar|P|', 'Catalán|Pilar|P|', 'Diez|Cristina|C|', 'Pineda-Tenor|Daniel|D|', 'Resino|Salvador|S|']
D000328:Adult D023241:Antiretroviral Therapy, Highly Active D018791:CD4 Lymphocyte Count D015496:CD4-Positive T-Lymphocytes D005260:Female D005838:Genotype D015658:HIV Infections D017320:HIV Protease Inhibitors D006801:Humans D053208:Kaplan-Meier Estimate D008297:Male D008875:Middle Aged D011110:Polymorphism, Genetic D020641:Polymorphism, Single Nucleotide D016016:Proportional Hazards Models D020395:Receptors, Interleukin-7 D012189:Retrospective Studies D018894:Reverse Transcriptase Inhibitors D013030:Spain D016896:Treatment Outcome D019562:Viral Load
IL7RA polymorphisms antiretroviral therapy AIDS immune system reconstitution