Unprecedented chemosensing behavior of novel tetra-substituted benzimidazole zinc(II) phthalocynine for selective detection of Bi3+ ion: Synthesis, characterization and ROS generation.
In this work, synthesis of novel symmetrical 4-(2-bromo-4-(5-bromo-1H-benzo[d] imidazol-2-yl) phenoxy) tetra substituted zinc phthalocyanine has been reported. The novel benzimidazole zinc phthlocynine compound (3) has been characterized by MALDI-TOF MS, FT-IR, UV-vis, and 1H NMR spectroscopy. This new compound 3 displayed excellent selectivity towards Bi3+ ion in the presence of other competitive ions including Ca2+, Cd2+, Co2+ Cu2+, Fe3+, Hg2+, Sn2+, Mg2+, Na+, Ni2+ and Pb2+ respectively. Upon addition of Bi3+ into the solution of compound 3 in DMSO, dramatic change was observed in the Q- and the B-bands in UV-visible spectra as a result of donor acceptor interactions. Reactive oxygen species (ROS) were also studied using 2,7-dichlorofluorescin diacetate (DCFH-DA) a fluorescent probe which is converted to highly fluorescent dichlorofluorescein (DCF) in the presence of ROS. This property of non-aggregating zinc phthalocyanine is promising as a photosensitizer in photodynamic therapy of cancer.
['Ullah|Azeem|A|', 'Shah|Faheem|F|', 'Khan|Imran|I|', 'Anwar|Muhammad|M|', 'Shah|Kiramat|K|', 'Muhammad|Munira Taj|MT|', 'Ahmad|Farid|F|']
D001562:Benzimidazoles D001729:Bismuth D004583:Electrons D007211:Indoles D007477:Ions D054833:Isoindoles D009942:Organometallic Compounds D017382:Reactive Oxygen Species D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization D013056:Spectrophotometry, Ultraviolet D017967:Zinc Compounds
Zinc phthalocyanine Reactive oxygen species Bi(3+) Chemosensor