mTOR Pathway is Involved in Energy Homeostasis Regulation as a Part of the Gut-Brain Axis.
Mammalian, or mechanic, target of rapamycin (mTOR) signaling is a crucial factor in the regulation of the energy balance that functions as an energy sensor in the body. The present review explores how the mTOR/S6k intracellular pathway is involved in modulating the production of different signals such as ghrelin and nesfatin-1 in the gastrointestinal tract to regulate food intake and body weight. The role of gastric mTOR signaling in different physiological processes was studied in depth through different genetic models that allow the modulation of mTOR signaling in the stomach and specifically in gastric X/A type cells. It has been described that mTOR signaling in X/A-like gastric cells has a relevant role in the regulation of glucose and lipid homeostasis due to its interaction with different organs such as liver and adipose tissue. These findings highlight possible therapeutic strategies, with the gut-brain axis being one of the most promising targets in the treatment of obesity.
['Pena-Leon|Veronica|V|0000-0002-2438-1712', 'Perez-Lois|Raquel|R|0000-0001-7352-3580', 'Seoane|Luisa Maria|LM|0000-0003-1004-9898']
D000273:Adipose Tissue D000818:Animals D004435:Eating D005753:Gastric Mucosa D054439:Ghrelin D005947:Glucose D006019:Glycolysis D006706:Homeostasis D006801:Humans D007031:Hypothalamus D050356:Lipid Metabolism D008099:Liver D015398:Signal Transduction D058570:TOR Serine-Threonine Kinases
mTOR homeostasis ghrelin nesfatin-1 gastrointestinal tract obesity