Investigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand Undaria pinnatifida in Combination with GroA Therapy in Prostate Cancer Cell Lines.
Fucoidan, a sulfated polysaccharide extracted from brown seaweeds, has been shown to possess various antioxidant, anticoagulant, antiviral, and anticancer functions. In this study, we focused on low molecular weight fucoidan (LMWF) which was extracted from New Zealand Undaria pinnatifida, and investigated its anti-proliferative effects, combined with a quadruplex-forming oligonucleotide aptamer (GroA, AS1411), a powerful cell surface Nucleolin inhibitor, in prostate cancer cells. We examined LMWF (<10 kDa) and compared it with laboratory grade Fucoidan purchased from Sigma (FS), all extracted from the same seaweed species U. pinnatifida. We found that LMWF significantly improved the anti-proliferative effect of GroA, as it decreased cancer cell growth and viability and increased cell death. This research may provide the foundation for LMWF to be used against prostate cancers as a supplement therapy in combination with other therapeutic agents.
['Yang|Xu|X|', 'Wang|Sheng|S|', 'Trangle|Sari Schokoroy|SS|', 'Li|Yan|Y|', 'White|William Lindsey|WL|', 'Li|Jinyao|J|', 'Ying|Tianlei|T|', 'Kong|Qingjun|Q|', 'Zhao|Yu|Y|', 'Lu|Jun|J|0000-0003-0225-6643']
D000971:Antineoplastic Combined Chemotherapy Protocols D017209:Apoptosis D052157:Aptamers, Nucleotide D045744:Cell Line, Tumor D049109:Cell Proliferation D002470:Cell Survival D004354:Drug Screening Assays, Antitumor D006801:Humans D008297:Male D008970:Molecular Weight D009520:New Zealand D009838:Oligodeoxyribonucleotides D011134:Polysaccharides D011471:Prostatic Neoplasms D012624:Seaweed D044648:Undaria
fucoidan Undaria pinnatifida GroA prostate cancer low molecular weight fucoidan Nucleolin