Toxicity mechanism of titanium dioxide and zinc oxide nanoparticles against food pathogens.
Food preservation is an important field of research. It extends the shelf life of major food products. Our current study is based on food preservation through TiO2 and ZnO nanoparticles. TiO2 and ZnO are biocompatible nanomaterial. The biocompatibility of the materials were established through toxicity studies on cell lines. Titanium dioxide and Zinc Oxide nanoparticle were synthesized by wet chemical process. They are characterized by X-Ray diffraction and TEM. The antibacterial activities of both the materials were analysed to ensure their effectiveness as food preservative against Salmonella typhi, Klebsiella pneumoniae and Shigella flexneri. The results indicates that TiO2 and ZnO nanoparticle inhibits Salmonella, Klebsiella and Shigella. The mode of action is by the generation of ROS in cases of Salmonella, Klebsiella. Mode of action in Shigella is still unclear. It was also proved that TiO2 and ZnO nanoparticle are biocompatible materials.
['Venkatasubbu|G Devanand|GD|', 'Baskar|R|R|', 'Anusuya|T|T|', 'Seshan|C Arun|CA|', 'Chelliah|Ramachandran|R|']
D000900:Anti-Bacterial Agents D001672:Biocompatible Materials D045744:Cell Line, Tumor D002470:Cell Survival D053938:DNA Fragmentation D005516:Food Microbiology D005520:Food Preservatives D006801:Humans D007711:Klebsiella pneumoniae D053768:Metal Nanoparticles D046529:Microscopy, Electron, Transmission D049329:Nanostructures D017382:Reactive Oxygen Species D012485:Salmonella typhi D012763:Shigella flexneri D014025:Titanium D014961:X-Ray Diffraction D015034:Zinc Oxide
Titanium dioxide Zinc oxide Food pathogens Salmonella Klebsiella Shigella flexneri