Herpes simplex virus 2 hepatitis in a lung transplant recipient: a diagnostic challenge.
Herpes simplex virus (HSV) hepatitis is a rare and serious complication in immunocompromised patients. We report the case of an HSV hepatitis occurring 4 years after lung transplantation in a cystic fibrosis patient. The presentation was nonspecific, mimicking acute cholecystitis; orogenital signs were absent. The diagnosis was made based on viral cultures performed during cholecystectomy and confirmed by blood quantitative polymerase chain reaction. Although the diagnosis and treatment were delayed, the patient fully recovered with acyclovir, reduced immunosuppression, and intravenous immunoglobulins. The diagnostic difficulties, prognostic factors, and treatments of this infection are discussed.
['Hirschi|S|S|', 'Biondini|D|D|', 'Ohana|M|M|', 'Solis|M|M|', "D'Urso|A|A|", 'Rosner|V|V|', 'Kessler|R|R|']
D000212:Acyclovir D000328:Adult D000998:Antiviral Agents D005260:Female D006525:Hepatitis, Viral, Human D018258:Herpesvirus 2, Human D006801:Humans D016867:Immunocompromised Host D016756:Immunoglobulins, Intravenous D016040:Lung Transplantation
herpes simplex virus hepatitis lung transplantation quantitative polymerase chain reaction