Morphine and myocardial ischaemia-reperfusion.
Coronary heart disease (CHD) is a cardiovascular disease with high mortality and disability worldwide. The main pathological manifestation of CHD is myocardial injury due to ischaemia-reperfusion, resulting in the death of cardiomyocytes (apoptosis and necrosis) and the occurrence of cardiac failure. Morphine is a nonselective opioid receptor agonist that has been commonly used for analgesia and to treat ischaemic heart disease. The present review focused on morphine-induced protection in an animal model of myocardial ischaemia-reperfusion and chronic heart failure and the effects of morphine on ST segment elevation myocardial infarction (STEMI) patients who underwent pre-primary percutaneous coronary intervention (pre-PPCI) or PPCI. The signalling pathways involved are also briefly described.
['Wu|Li-Ning|LN|', 'Hu|Rui|R|', 'Yu|Jun-Ma|JM|']
D000818:Animals D002317:Cardiovascular Agents D002908:Chronic Disease D004195:Disease Models, Animal D006333:Heart Failure D006801:Humans D009020:Morphine D015428:Myocardial Reperfusion Injury D032383:Myocytes, Cardiac D062645:Percutaneous Coronary Intervention D000072657:ST Elevation Myocardial Infarction D015398:Signal Transduction D016896:Treatment Outcome
Morphine Myocardial ischaemia-reperfusion Chronic heart failure ST segment Elevation myocardial infarction