Inflammatory cytokines kinetics define the severity and phase of nephropathia epidemica.
AIMS
Nephropathia epidemica (NE) is a form of hemorrhagic fever with renal syndrome associated with the Puumala virus species of Hantavirus. The pathogenesis of NE is not well understood; therefore, investigating the inflammatory cytokine response to infection may provide useful knowledge in deciphering the pathophysiology of NE.


MATERIALS & METHODS
Using Luminex and ELISA, we analyzed the serum of 137 NE cases and 44 controls to investigate if serum cytokines associate with different clinical presentations.


RESULTS
Serum levels of TNF-α and IL-1β are associated with disease severity while upregulation of IL-6, CXCL10, CCL2 and CCL3 are associated with clinical presentation.


CONCLUSION
Inflammatory cytokine kinetics associate with the severity and phase of NE. Our data support a role for inflammatory cytokines in the pathophysiology of NE.
['Baigildina|Asia A|AA|', 'Khaiboullina|Svetlana F|SF|', 'Martynova|Ekaterina V|EV|', 'Anokhin|Vladimir A|VA|', 'Lombardi|Vincent C|VC|', 'Rizvanov|Albert A|AA|']
D018932:Chemokine CCL2 D054405:Chemokine CCL3 D054357:Chemokine CXCL10 D016207:Cytokines D004797:Enzyme-Linked Immunosorbent Assay D005260:Female D006480:Hemorrhagic Fever with Renal Syndrome D006801:Humans D018836:Inflammation Mediators D053583:Interleukin-1beta D015850:Interleukin-6 D007700:Kinetics D008297:Male D012720:Severity of Illness Index D014409:Tumor Necrosis Factor-alpha
cytokine nephropathia epidemica Puumala virus Hantavirus HRFS