Effects of Bariatric Surgeries on the Size of Myocardial Infarction and Ghrelin Level in Rats with Experimental Decompensated Type 2 Diabetes Mellitus.
The effects of bariatric surgeries (sleeve gastrectomy and ileal transposition) on the dynamics of changes in ghrelin level were studied in rats with severe decompensated type 2 diabetes mellitus under conditions of glucose challenge as well as on the size of myocardial infarction in these animals. Diabetes was modelled by high fat diet and a single administration of streptozotocin (25 mg/kg, intraperitoneally). Both bariatric surgeries significantly decreased glucose-induced ghrelin level in the blood of rats with type 2 diabetes mellitus, which attested to an increase in the tissue sensitivity to ghrelin. Sleeve gastrectomy resulted in a decrease in the size of myocardial infarction in diabetic rats, which was calculated as the ratio of the necrosis zone to the zone of the risk of myocardial infarction. Ileal transposition had no effect on this parameter. Our data can be used as the basis for optimization of treatment approaches when using bariatric surgery in the treatment of patients with severe forms of type 2 diabetes mellitus with a high risk of cardiovascular diseases.
['Kornyushin|O V|OV|', 'Sonin|D L|DL|', 'Toropova|Ya G|YG|', 'Pochkaeva|E I|EI|', 'Semikova|G V|GV|', 'Berko|O M|OM|', 'Zelinskaya|I A|IA|', 'Todosenko|N M|NM|', 'Litvinova|L S|LS|', 'Neimark|A E|AE|', 'Babenko|A Yu|AY|', 'Dergach|K V|KV|', 'Schpakov|A O|AO|', 'Galagudza|M M|MM|']
D000818:Animals D050110:Bariatric Surgery D003921:Diabetes Mellitus, Experimental D003924:Diabetes Mellitus, Type 2 D059305:Diet, High-Fat D004195:Disease Models, Animal D005743:Gastrectomy D054439:Ghrelin D005947:Glucose D008297:Male D009203:Myocardial Infarction D051381:Rats D017208:Rats, Wistar D013311:Streptozocin
bariatric surgery myocardial infarction ghrelin type 2 diabetes mellitus glucose tolerance