Anhedonia is associated with reduced incentive cue related activation in the basal ganglia.
Research has shown that reward incentives improve cognitive control in motivationally salient situations. Much previous work in this domain has focused on incentive cue-related activity in a number of brain regions, including the dorsolateral prefrontal cortex (DLPFC) and striatum. However, the more sustained changes in functional brain activity during task contexts with incentives have been relatively less explored. Here, we examined both the cue-related and sustained effects of rewards (i.e., monetary incentives) on cognitive control, with a particular focus on the roles of the DLPFC and striatum, using a mixed state-item design. We investigated whether variability in a reward-related trait (i.e., anhedonia) would modulate the sustained and/or the cue-related transient aspects of motivated cognitive control. Twenty-seven healthy individuals performed a modified response conflict task (Padmala & Pessoa, Journal of Cognitive Neuroscience, 23, 3419-3432, 2011) during scanning, in which participants were asked to categorize images as either houses or buildings with either congruent or incongruent overlaid words. Participants performed a baseline condition without knowledge of monetary incentives, followed by reward blocks with monetary incentives on some cued trials (reward cues) for fast and correct responses. We replicated previous work by showing increases in both sustained activity during reward versus baseline blocks and transient. cue-related activity in bilateral DLPFC and the basal ganglia. Importantly, healthy individuals with higher anhedonia showed less of an increase in trial-by-trial activity as a function of reward in the lateral globus pallidus. Together, our results suggest that reduced hedonic experience may be related to abnormality of reward cue-related activity in the basal ganglia.
['Chung|Yu Sun|YS|', 'Barch|Deanna|D|']
D000328:Adult D059445:Anhedonia D001479:Basal Ganglia D001931:Brain Mapping D003220:Conflict, Psychological D003463:Cues D005260:Female D006801:Humans D007206:Individuality D008279:Magnetic Resonance Imaging D008297:Male D009483:Neuropsychological Tests D010364:Pattern Recognition, Visual D010775:Photic Stimulation D017397:Prefrontal Cortex D011569:Psychiatric Status Rating Scales D011930:Reaction Time D011932:Reading D012201:Reward
Reward Cognitive control Motivation Prefrontal cortex Emotion Mixed fMRI design