Mg2+ Transporters in Digestive Cancers.
Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this review, we describe the expression of Mg2+ transporters in digestive cancers, the most common and deadliest malignancies worldwide. Moreover, Mg2+ transporters' expression, correlation and impact on patient overall and disease-free survival is analyzed using Genotype Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Finally, we discuss the role of these Mg2+ transporters in the regulation of cancer cell fates and oncogenic signaling pathways.
['Auwercx|Julie|J|0000-0002-5873-4838', 'Rybarczyk|Pierre|P|', 'Kischel|Philippe|P|0000-0001-7201-2797', 'Dhennin-Duthille|Isabelle|I|0000-0003-1273-3511', 'Chatelain|Denis|D|', 'Sevestre|Henri|H|', 'Van Seuningen|Isabelle|I|0000-0002-3131-2694', 'Ouadid-Ahidouch|Halima|H|', 'Jonckheere|Nicolas|N|0000-0002-0496-0661', 'Gautier|Mathieu|M|0000-0001-8971-5683']
D000818:Animals D015415:Biomarkers D027682:Cation Transport Proteins D004198:Disease Susceptibility D005770:Gastrointestinal Neoplasms D015972:Gene Expression Regulation, Neoplastic D006706:Homeostasis D006801:Humans D017136:Ion Transport D008274:Magnesium D011485:Protein Binding D015398:Signal Transduction
digestive cancers magnesium transporters TCGA overall survival