Recurrent Thrombosis in Patients with Antiphospholipid Syndrome Receiving Newer Oral Anticoagulants: A Case Report and Review of Literature.
We present the case of a patient with primary APS who had a recurrence of thrombotic event while on treatment with rivaroxaban and had to be restarted on warfarin. The current literature on recurrence of thrombotic events in patients with antiphospholipid syndrome (APS) treated with newer oral anticoagulants (NOAC) is also reviewed. Relevant case reports and case series were identified by searching the Medline database using the key words antiphospholipid syndrome, anticoagulants and names of the NOACs, and data on individual patients was abstracted. We identified several reports on the failure of newer anticoagulants in APS, as well as cases and clinical trial results reporting efficacy. We conclude that treatment strategies for APS should be tailored cautiously when using NOACs.
['Joshi|Akanksha|A|', 'Hong|Jason|J|', 'Siva|Chokkalingam|C|']
D000284:Administration, Oral D000925:Anticoagulants D016736:Antiphospholipid Syndrome D005260:Female D006801:Humans D008875:Middle Aged D000069552:Rivaroxaban D013927:Thrombosis D014859:Warfarin
Newer oral anticoagulant Anticoagulants Rivaroxaban Warfarin Anti-cardiolipin antibodies Anti-phospholipid Syndrome Anti-ß2-glycoprotein antibodies