Pretreatment with 5-hydroxymethyl-2-furaldehyde blocks scopolamine-induced learning deficit in contextual and spatial memory in male mice.
5-Hydroxymethyl-2-furaldehyde (5-HMF) is a compound derived from the dehydration of certain sugars. The aim of the present study was to evaluate the effect of 5-HMF on the cognitive impairment induced by scopolamine, a muscarinic receptor antagonist. To measure various cognitive functions, we conducted the step-through passive avoidance task, the Y-maze task and the Morris water maze task. A single administration of 5-HMF (5 or 10mg/kg, p.o.) significantly attenuates scopolamine-induced cognitive impairment in these behavioral tasks without changes in locomotor activity, and the effect of 5-HMF on scopolamine-induced cognitive impairment was significantly reversed by a sub-effective dose of MK-801, an NMDA receptor antagonist. In addition, a single administration of 5-HMF (10mg/kg, p.o.) enhanced the cognitive performance of normal naïve mice in the passive avoidance task. Furthermore, Western blot analysis revealed that the levels of phosphorylated Ca(2+)/calmodulin-dependent protein kinase II-α (CaMKII) and extracellular signal-regulated kinases (ERK) were significantly enhanced by the single administration of 5-HMF in the hippocampal tissues. Taken together, the present study suggests that 5-HMF may block scopolamine-induced learning deficit and enhance cognitive function via the activation of NMDA receptor signaling, including CaMKII and ERK, and would be an effective candidate against cognitive disorders, such as Alzheimer's disease.
['Lee|Younghwan|Y|', 'Gao|Qingtao|Q|', 'Kim|Eunji|E|', 'Lee|Younghwa|Y|', 'Park|Se Jin|SJ|', 'Lee|Hyung Eun|HE|', 'Jang|Dae Sik|DS|', 'Ryu|Jong Hoon|JH|']
D000818:Animals D001362:Avoidance Learning D005662:Furaldehyde D008124:Locomotion D008297:Male D018782:Maze Learning D008568:Memory D051379:Mice D008813:Mice, Inbred ICR D016194:Receptors, N-Methyl-D-Aspartate D012601:Scopolamine D015398:Signal Transduction
5-Hydroxymethyl-2-furaldehyde 5-HMF Cognitive impairment Alzheimer's disease Learning and memory