Fluorescent magnetic submicronic polymer (FMSP) nanoparticles induce cell death in human colorectal carcinoma cells.
Nanoparticles have many advantages such as high biocompatibility, bioavailability and effective therapeutic capabilities. The aim of the present study is to examine whether fluorescent magnetic submicronic polymer nanoparticles (FMSP-nanoparticles) have any impact on human colorectal cancer cells. In the present study, we have tested FMSP-nanoparticles with an average size of 100-200 nm on human colorectal carcinoma cells (HCT-116) to check their cytotoxic and anti-cancer capabilities. The effects of FMSP-nanoparticles on cancer cells were observed after 6 h, 24 h and 48 h intervals. The response of FMSP-nanoparticles-treated cells was evaluated by Trypan Blue, 4lue-diamidino-2-phenylindole (DAPI) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Our MTT analysis results revealed that FMSP-nanoparticles produced dose-dependent effects on cancer cells, FMSP-nanoparticles with dose of 1.25 µg/mL did not decrease cell survivability, whereas dosages of 12.5 µg/mL and 50 µg/mL respectively showed 23.59% and 59.47% decrease in the cancer cell survivability. In conclusion, our results demonstrate FMSP-nanoparticles have a potential anti-cancer capability and hold a great promise for colon cancer treatments.
['Khan|Firdos Alam|FA|http://orcid.org/0000-0002-6892-1530', 'Akhtar|Sultan|S|', 'Almohazey|Dana|D|', 'Alomari|Munthar|M|', 'Almofty|Sarah Ameen|SA|', 'Eliassari|Abdelhamid|A|']
D000970:Antineoplastic Agents D017209:Apoptosis D049109:Cell Proliferation D015179:Colorectal Neoplasms D005456:Fluorescent Dyes D045325:HCT116 Cells D006801:Humans D058185:Magnetite Nanoparticles
Fluorescent magnetic submicronic polymer nanoparticles cytotoxicity colon cancer cell culture anticancer