Circulating irisin and chemerin levels as predictors of seizure control in children with idiopathic epilepsy.
Irisin and chemerin peptides expression are triggered by hypoxia and involved in activation of inflammatory cascades in various organs including the brain; however, their role in epilepsy is not fully illustrated. This study aims to explore the predictive role of irisin and chemerin for seizure control in children with idiopathic epilepsy. This cross-sectional comparative study included 50 children with idiopathic epilepsy; 25 of them had controlled seizures over the previous 6 months and 30 age- and sex-matched healthy children as controls. Epilepsy characteristics, seizure severity Chalfont score, and response to medications were assessed in relation to serum irisin and chemerin levels. In comparison to healthy controls, serum chemerin and irisin levels were significantly higher in children with idiopathic epilepsy especially those with uncontrolled seizures. Serum chemerin and irisin levels had significant positive correlation with seizure severity Chalfont score and the duration of epilepsy. Elevated Chalfont score (OR 3.19), serum chemerin (OR 2.01), and irisin (OR 2.03) are predictors of uncontrolled seizures. Circulating chemerin and irisin have 80% and 76% sensitivity and 88% and 92% specificity at cutoff point > 191.38 ng/ml and > 151.2 ng/ml respectively for prediction of uncontrolled seizures in children with idiopathic epilepsy. Elevated circulating level of irisin and chemerin may predict poor seizure control in children with idiopathic epilepsy suggesting the role of hypoxia-triggered neuroinflammation in the pathogenesis of childhood idiopathic epilepsy.
['Elhady|Marwa|M|http://orcid.org/0000-0002-7785-3736', 'Youness|Eman R|ER|', 'Gafar|Heba S|HS|', 'Abdel Aziz|Ali|A|', 'Mostafa|Rehab S I|RSI|']
D000704:Analysis of Variance D016022:Case-Control Studies D018925:Chemokines D002648:Child D002675:Child, Preschool D003430:Cross-Sectional Studies D004569:Electroencephalography D004827:Epilepsy D005260:Female D005353:Fibronectins D006801:Humans D036341:Intercellular Signaling Peptides and Proteins D008297:Male D011237:Predictive Value of Tests D012372:ROC Curve D012044:Regression Analysis D012189:Retrospective Studies D012720:Severity of Illness Index
Irisin Chemerin Children Epilepsy