Analysis of Blood Biomarkers in Patients with Chronic Obstructive Pulmonary Disease (COPD) and with Asthma-COPD Overlap (ACO).
Chronic obstructive pulmonary disease (COPD) is a heterogeneous entity with different clinical phenotypes, such as asthma-COPD overlap (ACO). The aim of this retrospective study was to compare routine blood biomarkers in patients with ACO and the remaning COPD phenotypes. Data were collected from stable COPD patients visited in during 2018, including C-reactive protein (CRP), fibrinogen, neutrophyl/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR).A total of 77 patients with COPD were included, 24 (31%) fulfilled the diagnosis of ACO. Clinically, patients with ACO presented more dyspnoea and wheezing. Regarding laboratory parameters, both groups had low levels of lymphocytes, especially the non-ACO group (24.2% vs. 29.3%; p = 0.031), patients with ACO had significantly higher eosinophil counts (4.7% vs. 1.9%; p < 0.001) but a lower percentage of neutrophils (56.8% vs. 64.7%; p = 0.003), NLR and PLR (2.5 vs. 3.8; p = 0.013 and 115 vs. 160; p = 0.063, respectively). In conclusion, besides the expected eosinophilic inflammation in patients with ACO, both groups had low levels of lymphocytes, especially the non-ACO group. The low levels of lymphocytes, in particular in non-ACO patients, should be confirmed in larger studies.
['Gava|Giordana|G|', 'Núñez|Alexa|A|', 'Esquinas|Cristina|C|', 'Sarasate|Mikel|M|', 'Loeb|Eduardo|E|', 'Pirina|Pietro|P|', 'Miravitlles|Marc|M|0000-0002-9850-9520', 'Barrecheguren|Miriam|M|']
D000368:Aged D000080445:Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome D015415:Biomarkers D002097:C-Reactive Protein D004417:Dyspnea D004802:Eosinophilia D004804:Eosinophils D005260:Female D005340:Fibrinogen D005541:Forced Expiratory Volume D006801:Humans D007958:Leukocyte Count D018655:Lymphocyte Count D008297:Male D008875:Middle Aged D009504:Neutrophils D010976:Platelet Count D029424:Pulmonary Disease, Chronic Obstructive D014797:Vital Capacity
biomarkers COPD ACO blood parameters