Proteome-wide data analysis reveals tissue-specific network associated with SARS-CoV-2 infection.
For patients with COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the damages to multiple organs have been clinically observed. Since most of current investigations for virus-host interaction are based on cell level, there is an urgent demand to probe tissue-specific features associated with SARS-CoV-2 infection. Based on collected proteomic datasets from human lung, colon, kidney, liver, and heart, we constructed a virus-receptor network, a virus-interaction network, and a virus-perturbation network. In the tissue-specific networks associated with virus-host crosstalk, both common and different key hubs are revealed in diverse tissues. Ubiquitous hubs in multiple tissues such as BRD4 and RIPK1 would be promising drug targets to rescue multi-organ injury and deal with inflammation. Certain tissue-unique hubs such as REEP5 might mediate specific olfactory dysfunction. The present analysis implies that SARS-CoV-2 could affect multi-targets in diverse host tissues, and the treatment of COVID-19 would be a complex task.
['Feng|Li|L|', 'Yin|Yuan-Yuan|YY|', 'Liu|Cong-Hui|CH|', 'Xu|Ke-Ren|KR|', 'Li|Qing-Run|QR|', 'Wu|Jia-Rui|JR|', 'Zeng|Rong|R|']
D000086382:COVID-19 D018797:Cell Cycle Proteins D003106:Colon D006321:Heart D000076662:Host Microbial Interactions D006801:Humans D007668:Kidney D008099:Liver D008168:Lung D008565:Membrane Proteins D053858:Metabolic Networks and Pathways D009206:Myocardium D058873:Pandemics D060066:Protein Interaction Maps D020543:Proteome D040901:Proteomics D053422:Receptor-Interacting Protein Serine-Threonine Kinases D011991:Receptors, Virus D000086402:SARS-CoV-2 D014018:Tissue Distribution D014157:Transcription Factors
proteome-wide tissue-specific SARS-CoV-2