Metabolic Regulation of Methionine Restriction in Diabetes.
Although the effects of dietary methionine restriction have been investigated in the physiology of aging and diseases related to oxidative stress, the relationship between methionine restriction (MR) and the development of metabolic disorders has not been explored extensively. This review summarizes studies of the possible involvement of dietary methionine restriction in improving insulin resistance, glucose homeostasis, oxidative stress, lipid metabolism, the pentose phosphate pathway (PPP), and inflammation, with an emphasis on the fibroblast growth factor 21 and protein phosphatase 2A signals and autophagy in diabetes. Diets deficient in methionine may be a useful nutritional strategy in patients with diabetes.
['Yin|Jie|J|0000-0003-1852-1042', 'Ren|Wenkai|W|', 'Chen|Shuai|S|', 'Li|Yuying|Y|', 'Han|Hui|H|', 'Gao|Jing|J|', 'Liu|Gang|G|', 'Wu|Xin|X|', 'Li|Tiejun|T|', 'Woo Kim|Sung|S|', 'Yin|Yulong|Y|']
D000818:Animals D001343:Autophagy D003920:Diabetes Mellitus D005947:Glucose D006801:Humans D007333:Insulin Resistance D050356:Lipid Metabolism D008715:Methionine D018384:Oxidative Stress D010427:Pentose Phosphate Pathway
methionine restriction diabetes oxidative stress insulin