Applications of amide isosteres in medicinal chemistry.
Isosteric replacement of amide groups is a classic practice in medicinal chemistry. This digest highlights the applications of most commonly employed amide isosteres in drug design aiming at improving potency and selectivity, optimizing physicochemical and pharmacokinetic properties, eliminating or modifying toxicophores, as well as providing novel intellectual property of lead compounds.
['Sun|Shaoyi|S|', 'Jia|Qi|Q|', 'Zhang|Zaihui|Z|']
D000577:Amides D002626:Chemistry, Pharmaceutical D015195:Drug Design D015394:Molecular Structure
Amide isostere 3-Aminooxetane Boronic acid Fluoroalkene Heterocycle Transition-state mimic Trifluoroethylamine