CAG regimen for refractory or relapsed adult T-cell acute lymphoblastic leukemia: A retrospective, multicenter, cohort study.
Adult patients with relapsed or refractory T-cell acute lymphoblastic leukemia (R/R-T-ALL) have extremely poor prognosis, representing an urgent unmet medical need. Finding an optimal salvage regimen to bridge transplantation is a priority. The CAG (cytarabine, aclarubicin, and G-CSF) regimen was initially used by one group in China, showing unexpectedly promising results in 11 R/R-T-ALL patients. Here, we report the multicenter results of 41 patients who received the CAG regimen as salvage therapy. After one cycle of the CAG regimen, complete remission and partial remission were achieved in 33 (80.5%) and two (4.9%) patients, respectively. Failure to respond was observed in six patients (14.6%). Early T-cell precursor (ETP) (n = 26) and non-ETP (n = 15) patients had a similar CR rate (80.8% vs 80.0%, P = .95). Among 41 patients, allo-HSCT was successfully performed in 27 (66%) patients (22 in CR and 5 in non-CR). With a median follow-up time of 12 months, the estimated 2-year overall survival and event-free survival were 68.8% (95% CI, 47.3%-83.0%) and 56.5% (95% CI, 37.1%-71.9%), respectively. The CAG regimen was well-tolerated, and no early death occurred. Our multicenter results show that the CAG regimen is highly effective and safe, representing a novel choice for adult patients with R/R-T-ALL and providing a better bridge to transplantation.
['Qian|Jie-Jing|JJ|', 'Hu|Xiaoxia|X|0000-0002-2719-3805', 'Wang|Ying|Y|', 'Zhang|Yi|Y|', 'Du|Juan|J|0000-0003-2538-4007', 'Yang|Min|M|', 'Tong|Hongyan|H|', 'Qian|Wen-Bin|WB|', 'Wei|Juying|J|', 'Yu|Wenjun|W|', 'Lou|Yin-Jun|YJ|', 'Mao|Liping|L|', 'Tao Meng|Hai|H|', 'You|Liang-Shun|LS|', 'Wang|Libing|L|', 'Li|Xia|X|', 'Huang|Xin|X|', 'Cao|Li-Hong|LH|', 'Zhao|Jian-Zhi|JZ|', 'Yan Yan|Xiao|X|', 'Chen|Yu-Bao|YB|', 'Chen|Yu|Y|', 'Zhang|Su-Jiang|SJ|', 'Jin|Jie|J|0000-0002-8166-9915', 'Hu|Jiong|J|', 'Zhu|Hong-Hu|HH|0000-0003-2343-0436']
D015250:Aclarubicin D000293:Adolescent D000328:Adult D000368:Aged D000971:Antineoplastic Combined Chemotherapy Protocols D015331:Cohort Studies D003561:Cytarabine D005260:Female D016179:Granulocyte Colony-Stimulating Factor D006801:Humans D008297:Male D008875:Middle Aged D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma D012189:Retrospective Studies D055815:Young Adult
refractory or relapse T-cell acute lymphoblastic leukemia stem cell transplantation