Effect of flurbiprofen axetil on postoperative delirium for elderly patients.
OBJECTIVES
Proinflammatory cytokines triggered by surgery and postoperative pain are major causes of postoperative delirium (POD). This study investigated the effects of flurbiprofen axetil on POD when used for postoperative analgesia after major noncardiac surgery in elderly patients.


METHODS
Patients over 65 years old were randomly divided into two groups: the sufentanil group (S group), in which 150 μg of sufentanil was used in the patient-controlled analgesia (PCA) pump for 3 days; the sufentanil combined with flurbiprofen axetil group (SF group), in which 150 μg of sufentanil was combined with 300 mg of flurbiprofen axetil in the PCA pump for 3 days. The Confusion Assessment Method scale was used for POD evaluation. The pain intensity, side effects, and risk factors (age, gender, surgical position, and category of surgery) for POD were evaluated.


RESULTS
Ultimately, 140 patients were included. The overall incidence of POD was not significantly different between the S and SF groups. The incidence of POD was significantly lower in the SF group than in the S group among patients over 70 years (5.1% vs. 20.7%, p = 0.045, odds ratio = 0.146, 95% confidence interval = 0.020-1.041). The incidence of POD was no difference in patients classified by the category of surgery, surgical position, or gender between groups. Sufentanil and flurbiprofen axetil in the PCA pump was completely used within 72 hr. The pain intensity, consumed sufentanil dosage of the PCA, and the side effects was not different between groups.


CONCLUSIONS
Flurbiprofen axetil might reduce POD in patients over 70 years undergoing major noncardiac surgery.
['Wang|Xifan|X|', 'Wang|Yu|Y|', 'Hu|Yanan|Y|', 'Wang|Liping|L|', 'Zhao|Wenshuai|W|', 'Wei|Lanying|L|', 'Chen|Hong|H|', 'Han|Fei|F|0000-0001-8370-1870']
D000368:Aged D000701:Analgesics, Opioid D000894:Anti-Inflammatory Agents, Non-Steroidal D003693:Delirium D004311:Double-Blind Method D004359:Drug Therapy, Combination D005260:Female D005480:Flurbiprofen D006801:Humans D008297:Male D010149:Pain, Postoperative D011183:Postoperative Complications D011446:Prospective Studies D017409:Sufentanil
flurbiprofen axetil postoperative delirium patient-controlled analgesia elder