Onion extract gel is not better than other topical treatments in scar management: A meta-analysis from randomised controlled trails.
To evaluate the efficacy and safety of onion extract (OE) gel on scar management, a systematic review was performed by searching Embase, PubMed, Medline, and the Cochrane Library databases, and a meta-analysis was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines. Finally, 13 randomised controlled trails were enrolled for meta-analysis. OE gel increased the total improvement scores assessed by investigators (P < .00001) and patients (P < .00001) than no treatment, but no differences were detected between OE gel and other commonly used topical treatments assessed by investigators (P = .56) and patients (P = .39). Moreover, OE in silicone gel increased the total improvement scores assessed by investigators (P < .00001) and patients (P = .0007) than other treatments. OE gel increased the incidence of total adverse effects compared with no treatment (P < .0001) and other treatments (P = .008) by a fixed-effects model, and increased the incidence of dropping out caused by intolerance of treatments (P = .0002). OE gel not only has no superiority to commonly used topical treatments, but also has the potential to increase the incidence of adverse effects on scar management; OE in silicone gel might be the optimal topical choice for scar treatment; however, more evidences are needed to strength these conclusions.
['Yuan|Xi|X|', 'Shen|Jie|J|', 'Chen|Li|L|', 'Wang|Liang|L|', 'Yan|Qing|Q|', 'Zhang|Jiaping|J|']
D002921:Cicatrix D005260:Female D006801:Humans D019697:Onions D010936:Plant Extracts D016032:Randomized Controlled Trials as Topic D020034:Silicone Gels D013785:Thailand
onion extract gel scar meta-analysis