Chromoblastomycosis caused by Fonsecaea: clinicopathology, susceptibility and molecular identification of seven consecutive cases in Southern China.
The clinicopathological and microbiological features of chromoblastomycosis caused by Fonsecaea pedrosoi or Fonsecaea monophora are summarized. Four F. monophora and three F. pedrosoi strains were isolated from seven consecutive chromoblastomycosis patients and identified by genetic analysis between 2004 and 2012 in a teaching hospital in southern China. Six strains were sensitive to voriconazole, itraconazole and terbinafine using E-test and Neo-Sensitabs. Six patients healed after oral itraconazole or terbinafine, and one was lost to follow up. Internal transcribed spacer sequence is sufficient for species delimitation of Fonsecaea, and the Neo-Sensitabs test and E-test are comparable in their susceptibility testing. Itraconazole and/or terbinafine may be the preferred treatment for this chromoblastomycosis.
['Yang|Y-P|YP|', 'Li|W|W|', 'Huang|W-M|WM|', 'Zhou|Y|Y|', 'Fan|Y-M|YM|']
D000284:Administration, Oral D000368:Aged D000369:Aged, 80 and over D000935:Antifungal Agents D001203:Ascomycota D002681:China D002862:Chromoblastomycosis D004271:DNA, Fungal D005260:Female D006784:Hospitals, Teaching D006801:Humans D017964:Itraconazole D008297:Male D008826:Microbial Sensitivity Tests D008875:Middle Aged D008969:Molecular Sequence Data D009281:Naphthalenes D011743:Pyrimidines D017422:Sequence Analysis, DNA D000077291:Terbinafine D016896:Treatment Outcome D014230:Triazoles D065819:Voriconazole
Chromoblastomycosis Fonsecaea pedrosoi Fonsecaea monophora susceptibility test strain identification