RETRACTED: Glyphosate herbicide induces genotoxic effect and physiological disturbances in Bulinus truncatus snails.
Herbicides are being used in agriculture for controlling noxious weed. Glyphosate is a herbicide that is widely applied to cereal crops in Egypt and is used in controlling a very broad spectrum of weeds. The present study was designed to investigate the response of the snail Bulinus truncatus as a bioindicator for physiological and molecular aspects of B. truncatus snails after exposure to sublethal concentrations of glyphosate for two weeks. In treating snails, glucose concentration (GL) in the haemolymph as well as lactate (LT) in soft tissues of treated snails increased, while glycogen (GN), pyruvate (PV), total protein (TP), nucleic acids (DNA and RNA) levels in snail's tissues decreased. The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR), thioredoxin reductase (TrxR), glycogen phosphorylase (GP), glucose-6-phosphatase (G-6-Pase), succinic dehydrogenase (SDH) and lactic dehydrogenase (LDH) enzymes in homogenate of snail's tissues were reduced in response to the treatment with the herbicide, while lipid peroxide (LP), sorbitol dehydrogenase (SDH) and transaminases (GOT and GPT) activity increased (P < 0.001). The changes in the number, position and intensity of DNA bands induced by glyphosate herbicide may be attributed to the fact that the herbicide can induce genotoxicity through DNA damage. Thus, the present result indicated that the genotoxicity products at low concentration and for long time treatment showed the hazard of herbicide addiction on man's life.
['Bakry|Fayez A|FA|', 'Ismail|Somaya M|SM|', 'Abd El-Atti|Mahmoud S|MS|']
D000818:Animals D002033:Bulinus D002374:Catalase D004249:DNA Damage D005980:Glutathione Reductase D005998:Glycine D024981:Glycogen Phosphorylase D006540:Herbicides D008054:Lipid Peroxides D013482:Superoxide Dismutase D013880:Thioredoxin-Disulfide Reductase D000637:Transaminases
Glyphosate herbicide Bulinus truncatus snails Molecular genetic The physiological effects