Pattern recognition receptors in fungal immunity.
Over the last decade, invasive fungal infections have emerged as a growing threat to human health worldwide and novel treatment strategies are urgently needed. In this context, investigations into host-pathogen interactions represent an important and promising field of research. Antigen presenting cells such as macrophages and dendritic cells are strategically located at the frontline of defence against potential invaders. Importantly, these cells express germline encoded pattern recognition receptors (PRRs), which sense conserved entities from pathogens and orchestrate innate immune responses. Herein, we review the latest findings regarding the biology and functions of the different classes of PRRs involved in pathogenic fungal recognition. We also discuss recent literature on PRR collaboration/crosstalk and the mechanisms involved in inhibiting/regulating PRR signalling. Finally, we discuss how the accumulated knowledge on PRR biology, especially Dectin-1, has been used for the design of new immunotherapies against fungal infections.
['Patin|Emmanuel C|EC|', 'Thompson|Aiysha|A|', 'Orr|Selinda J|SJ|']
D003713:Dendritic Cells D005658:Fungi D005854:Germ Cells D054884:Host-Pathogen Interactions D006801:Humans D007113:Immunity, Innate D000072742:Invasive Fungal Infections D008264:Macrophages D051192:Receptors, Pattern Recognition
Crosstalk C-type lectin-like receptor Nod-like receptor Pathogen recognition receptor Toll-like receptor