Pancreas and kidney changes in type 2 diabetes patients: the role of diffusion-weighted imaging
Background/aim
The aim of this study was to compare renal and pancreatic apparent diffusion-coefficient (ADC) values of diabetic
patients and control subjects and to examine their potential association with several diabetes-related clinical parameters.


Materials and methods
A total of 80 sex- and age-matched patients were included in the study. Of them, 40 were patients with type 2 diabetes and 40 were nondiabetic participants. Abdominal diffusion-weighted MRIs of both groups were retrospectively reviewed. Diabetes-related clinical parameters were recorded.


Results
The difference between the mean ADC values of the patient group and the control group was significant (p = 0.012). It was also found that the mean pancreatic ADC values of diabetic patients and the control group significantly differed (p = 0.02). Besides, there were positive correlations between the mean pancreatic ADC values and age, Hb1Ac level, treatment type, and disease duration (p < 0.05). While eGFR values positively correlated with the mean renal ADC values (p < 0.05), there were negative correlations between such values and age, serum creatinine level, and disease duration (p < 0.05).


Conclusion
Renal and pancreatic ADC values of diabetic patients could potentially play a role, as markers of renal and pancreatic functions, in clinical decisions in the follow-up of such patients.
['Şahan|Mehmet Hamdi|MH|0000-0001-8976-6157', 'Özdemir|Adnan|A|0000-0003-0652-5396', 'Asal|Neşe|N|0000-0002-3787-556X', 'Karadeniz Bilgili|Yasemin Mirace|YM|0000-0002-2368-5239', 'Doğan|Adil|A|0000-0002-2501-1852', 'Güngüneş|Aşkın|A|0000-0002-8998-9729']
pancreas kidney Diabetes mellitus diffusion-weighted imaging magnetic resonance imaging