Correlation between factor VII and PAI-1 genetic variants and recurrent miscarriage.
BACKGROUND
Polymorphisms which are presented below may be the cause of inherited thrombophilia and may result in pregnancy loss. The hypothesis is based on a number of cardiology studies which have confirmed the involvement of these polymorphisms in thrombotic incidents.


OBJECTIVES
To evaluate the role of polymorphisms of factor VII gene (Arg353Gln, -122T > C) and PAI-1 gene (-675 4G/5G) in the etiology of recurrent miscarriage.


MATERIAL AND METHODS
The study group included 152 women with a positive history of ≥ 2 consecutive pregnancy losses (114 and 38 women with 2 and ≥ 3 miscarriages, respectively), while 180 healthy women were recruited as controls. Genetic analysis was performed with the use of PCR/RFLP.


RESULTS
Lower frequency of Arg353/Gln353 was observed in women with 2 and ≥ 3 miscarriages as compared to controls (21.1% vs. 23.9% and 13.2% vs. 23.9%, respectively). The frequency of Gln353 was lower in women with ≥ 3 miscarriages as compared to controls (6.6% vs. 11.9%, p = ns). The frequency of -122TT was higher in women with ≥ 3 miscarriages as compared to controls (86.84% vs. 76.67%, p = ns), whereas -122TC was more frequent in controls (13.16% vs. 22.78% in controls, p = ns). The frequency of -122T was higher in patients with ≥ 3 abortions as compared to controls (93.42% vs. 88.06%, p = ns), and -122C was observed more frequently in controls (6.58% vs. 11.94% in controls, p = ns). There were no significant differences as far as the -675 4G/5G polymorphism was concerned.


CONCLUSIONS
The obtained results suggest a possible protective role of Gln353 and -122C alleles in recurrent miscarriage.
['Barlik|Magdalena|M|', 'Seremak-Mrozikiewicz|Agnieszka|A|', 'Drews|Krzysztof|K|', 'Klejewski|Andrzej|A|', 'Kurzawińska|Grażyna|G|', 'Łowicki|Zdzisław|Z|', 'Wolski|Hubert|H|']
D000026:Abortion, Habitual D000328:Adult D005167:Factor VII D005260:Female D006801:Humans D017395:Plasminogen Activator Inhibitor 1 D011110:Polymorphism, Genetic D011247:Pregnancy D065840:Protective Factors D019851:Thrombophilia
thrombophilia pregnancy loss gene polymorphism