Inhibition of sodium-glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis-related kidney disease.
The effect of sodium-glucose cotransporter 2 inhibitor (SGLT2I) on nonalcoholic steatohepatitis (NASH) has been reported, but there are few studies on its effect on NASH-related renal injury. In this study, we examined the effect of SGLT2I using a novel medaka fish model of NASH-related kidney disease, which was developed by feeding the d-rR/Tokyo strain a high-fat diet. SGLT2I was administered by dissolving it in water of the feeding tank. SGLT2I ameliorates macrophage accumulation and oxidative stress and maintained mitochondrial function in the kidney. The results demonstrate the effect of SGLT2I on NASH-related renal injury and the usefulness of this novel animal model for research into NASH-related complications.
['Nagoya|Takuro|T|', 'Kamimura|Kenya|K|0000-0001-7182-4400', 'Goto|Ryo|R|', 'Shinagawa-Kobayashi|Yoko|Y|', 'Niwa|Yusuke|Y|', 'Kimura|Atsushi|A|', 'Sakai|Norihiro|N|', 'Ko|Masayoshi|M|', 'Nishina|Hiroshi|H|', 'Terai|Shuji|S|']
D000818:Animals D001559:Benzhydryl Compounds D003924:Diabetes Mellitus, Type 2 D059305:Diet, High-Fat D004195:Disease Models, Animal D005947:Glucose D005960:Glucosides D050491:Glutamate Plasma Membrane Transport Proteins D007004:Hypoglycemic Agents D007668:Kidney D007674:Kidney Diseases D065626:Non-alcoholic Fatty Liver Disease D009990:Oryzias D012964:Sodium D000077203:Sodium-Glucose Transporter 2 Inhibitors
kidney NASH Oryzias latipes SGLT2 inhibitor medaka disease model renal disease