Structure-function Relationships in Uveitic Cystoid Macular Edema: Using En Face Optical Coherence Tomography to Predict Vision.
PURPOSE
To explore whether preserved retinal tissue on baseline en face optical coherence tomography (OCT) correlates with post-treatment visual acuity in patients with uveitis-associated cystoid macular edema (CME).


METHODS
A retrospective cohort study was conducted on 25 eyes (23 patients) with uveitis and CME, with resolution of CME at post-treatment follow-up. Baseline en face OCT images were analyzed to determine the proportion of pixels representing preserved retinal tissue. Macular thickness and volume data were also analyzed.


RESULTS
The proportion of preserved retinal tissue on baseline OCT strongly correlated with baseline visual acuity (r = 0.61, p = 0.0014), and correlated even better with vision after CME resolution (r = 0.73, p < 0.0001). Weak correlations were found between macular thickness and volume at baseline and post-treatment acuity (r = 0.38, p = 0.058 and r = 0.39, p = 0.055).


CONCLUSIONS
Preserved retinal tissue at baseline strongly correlates with post-treatment visual acuity in patients with uveitis-associated CME, and is a better predictor of future vision than macular thickness or volume.
['Cohen|Liza M|LM|', 'Goldstein|Debra A|DA|', 'Fawzi|Amani A|AA|']
D000293:Adolescent D000328:Adult D000368:Aged D020533:Angiogenesis Inhibitors D000894:Anti-Inflammatory Agents, Non-Steroidal D005260:Female D005938:Glucocorticoids D006801:Humans D008269:Macular Edema D008297:Male D008875:Middle Aged D012160:Retina D012189:Retrospective Studies D041623:Tomography, Optical Coherence D014605:Uveitis D014792:Visual Acuity D055815:Young Adult
Cystoid macular edema optical coherence tomography uveitis image analysis retina