Combination treatment of oral terbinafine with topical terbinafine and 10% urea ointment in hyperkeratotic type tinea pedis.
Hyperkeratotic-type tinea pedis is chronic and recalcitrant to topical antifungal agents. Some topical antifungal agents are effective; however, long duration of therapy is required, which often reduce the treatment compliance of patients. To seek for short period therapy of hyperkeratotic type tinea pedis, in this study, we observed the efficacy and safety of treatment of topical terbinafine and 10% urea ointment combined oral terbinafine. Participants with hyperkeratotic type tinea pedis were randomly assigned to two groups. Patients in group I were treated with oral terbinafine for 2 weeks and topical terbinafine and 10% urea ointment for 4 weeks, whereas in group II, only the above topical agents were applied for 12 weeks. Clinical improvement rates and fungal eradication rates were compared between the two groups at 24 weeks after the initiation of treatment. The group I had stopped the topical therapy 8 weeks earlier than group II. There were no significant differences in mycological eradication rates and clinical improvement rates between the two groups, besides, no major side effects were noted in both groups. The short combination therapy with oral terbinafine was effective and safe; it should be a valuable option for patients with hyperkeratotic type tinea pedis.
['Shi|Tian-Wei|TW|', 'Zhang|Jiang-An|JA|', 'Zhang|Xian-Wei|XW|', 'Yu|Hong-Xing|HX|', 'Tang|Yong-Bo|YB|', 'Yu|Jian-Bin|JB|']
D000284:Administration, Oral D000287:Administration, Topical D000328:Adult D000368:Aged D000935:Antifungal Agents D004359:Drug Therapy, Combination D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D009281:Naphthalenes D009824:Ointments D011446:Prospective Studies D000077291:Terbinafine D014008:Tinea Pedis D016896:Treatment Outcome D014508:Urea D055815:Young Adult
treatment Terbinafine urea ointment hyperkeratotic type tinea pedis