Monocenter study on epidemiology, outcomes, and risk factors of infections in recipients of 166 allogeneic stem cell transplantations during 1 year.
OBJECTIVES
During allogeneic hematopoietic stem cell transplantation (allo-SCT), infections significantly contribute to morbidity and mortality. A monocentric prospective analysis was performed to assess epidemiology, risk factors, and outcomes of infections during the peri-transplant period.


METHODS
Data were recorded prospectively using a predefined questionnaire.


RESULTS
In 2015, 163 consecutive patients, 37.4% female, median age 59 (range 18-79) years received 166 allo-SCT. Median duration of leukopenia <109 /L was 14.5 days (range 4-43 days). Fever of unknown origin (FUO) occurred in 118/166 patients (71.1%). Severe sepsis developed in 95, and septic shock developed in 26 patients. Intensive diagnostic workup helped to identify causative microorganisms only in a small number of infectious courses. All but 13 patients needed antibiotic therapy, each according to the standard operating procedures of the department. Cumulative incidence of death by infection after 1 year was 16.6% (95% CI: 11.3-22.7). The only risk factor for FUO in neutropenia was duration of neutropenia </≥14 days (55.4% vs 85.5%, P < .001).


CONCLUSION
Results of an elaborate diagnostic workup of infections in the peri-transplant period are scarce. Attention to risk factors might help to identify patients at risk for severe infections.
['Samek|Markus|M|', 'Iversen|Katharina|K|', 'Belmar Campos|Cristina|C|', 'Berneking|Laura|L|', 'Langebrake|Claudia|C|', 'Wolschke|Christine|C|', 'Ayuk|Francis|F|', 'Kröger|Nicolaus|N|', 'Christopeit|Maximilian|M|https://orcid.org/0000-0003-4627-0412']
D000293:Adolescent D000328:Adult D000368:Aged D000900:Anti-Bacterial Agents D019468:Disease Management D004198:Disease Susceptibility D005260:Female D019538:Health Care Surveys D018380:Hematopoietic Stem Cell Transplantation D006801:Humans D015994:Incidence D007239:Infections D008297:Male D008875:Middle Aged D009503:Neutropenia D018570:Risk Assessment D012307:Risk Factors D014184:Transplantation, Homologous D055815:Young Adult
infection allogeneic stem cell transplantation FUO neutropenia