Analgesic efficacy of prophylactic gabapentin and lornoxicam in preventing postendodontic pain.
OBJECTIVE
In dental applications, as in all other medical applications, pain needs to be prevented or at least controlled. The use of the tooth as a model for studying pain mechanisms is well established. In the current study, we aimed to evaluate and compare the analgesic effects of gabapentin and lornoxicam, respectively, vs a placebo for postendodontic treatment pain.


DESIGN AND METHODS
Clinical research was planned as prospective, randomized, and placebo controlled. Each subject was given 600 mg gabapentin (group G: N = 30), 8 mg lornoxicam (group L: N = 30), or a placebo (group C: N = 30) 30 min prior to endodontic treatment.


OUTCOME MEASURES
At 4 (T(3)), 8 (T(4)), 12 (T(5)), and 24 (T(6)) h after preoperative (T(0)) time points, the analgesic efficacies of the agents were evaluated by using the visual analog scale (VAS).


RESULTS
In group G, VAS values were significantly greater at T(0) time point than at T(5) or T(6). T(0) time point VAS value in group L was lower than at T4 time point and greater than at T(6). In group C, T(0) time point VAS values were significantly lower at T(3) and T(5) time points and greater than at T(6) time point. VAS values in group G at T(5) time point were significantly lower than in group C or group L (P < 0.05).


CONCLUSIONS
Based on the obtained data, prophylactic lornoxicam controlled postendodontic treatment pain more effectively than did the placebo drugs, and gabapentin was more effective in controlling the pain than either lornoxicam or the placebo.
['Işik|Berrin|B|', 'Yaman|Sis|S|', 'Aktuna|Serkan|S|', 'Turan|Alparslan|A|']
D000328:Adult D000588:Amines D000700:Analgesics D003509:Cyclohexanecarboxylic Acids D004311:Double-Blind Method D005260:Female D000077206:Gabapentin D006801:Humans D008297:Male D010146:Pain D059408:Pain Management D010147:Pain Measurement D010894:Piroxicam D011446:Prospective Studies D012390:Root Canal Therapy D005680:gamma-Aminobutyric Acid
Prophylactic Gabapentin Lornoxicam Analgesia