Review of de novo cerebral arteriovenous malformation: haemorrhage risk, treatment approaches and outcomes.
Objective A small number of patients has been reported to develop a completely new or de novo arteriovenous malformation (AVM) after brain surgery, haemorrhage, head trauma or ischaemic stroke. The natural history of these lesions is unknown. In this review, both ruptured and unruptured de novo AVMs and their treatments were reviewed. Methods Published literature in the PubMed database citing 'de novo cerebral arteriovenous malformation' was reviewed. Additional studies were identified through reference searches in each reviewed article. A review was performed using all published cases, the treatment approaches and outcomes. Results A total of 38 patients, including 37 de novo AVMs reported from 1988 to 17 November 2017 and our one patient, was collected. The age at AVM diagnosis was 5-73 years (mean ± SD, 27.6 ± 20.5 years). The duration time, from negative examination to AVM diagnosis, was 2 months to 25 years (mean ± SD, 6.6 ± 4.9 years). The presentation of de novo AVM was headaches in three (7.9%) patients, bleedings in 12 (31.6%), incidental in 14 (36.8%) and seizure in nine (23.7%). The estimated risk of haemorrhage was 4.8% per year. Seventeen (44.7%) patients were treated with surgical resection, 10 (26.3%) were conservatively observed, nine (23.7%) were treated with radiosurgery and two (5.3%) were endovascularly embolised. The morbidity and mortality were reported as 5.3% and 7.9%, respectively. Conclusion Post-natal de novo AVMs have been reported. Their annual haemorrhage risk is 4.8%. Most of them are treated by surgical resection and are associated with morbidity and mortality.
['Lv|Xianli|X|', 'Wang|Guihuai|G|']
D000293:Adolescent D000328:Adult D000368:Aged D016009:Chi-Square Distribution D002648:Child D002675:Child, Preschool D004621:Embolization, Therapeutic D005260:Female D006261:Headache D006470:Hemorrhage D006801:Humans D002538:Intracranial Arteriovenous Malformations D008137:Longitudinal Studies D008297:Male D008875:Middle Aged D059906:Neuroimaging D039781:PubMed D016896:Treatment Outcome D055815:Young Adult
Arteriovenous malformation treatment outcome de novo AVM