Seroprevalency of transfusion-transmitted infections in first-time volunteer and replacement donors in Tunisia.
BACKGROUND
Replacement donors are considered as having a major risk of transmission of infections to recipients mainly by the World Health Organisation.


STUDY DESIGN AND METHODS
Seroprevalency of HBV, HCV, HIV and syphilis were determined in 19,783 whole blood donations collected in the Tunisian National Blood Transfusion Centre during the year 2010 (12,968 [65.55%] replacement donations and 6815 [34.44%] voluntary blood donations). For HBV, HCV and syphilis, we performed a univariate analysis to determine whether age, sex and type of donation were risk factors, then multivariate logistic regression, to see if these factors were independent.


RESULTS
Mean age of donors was 30.1 years (replacement donors 34.5 years, first time non-remunerated donors 34.5 years, P<0.001). The predominant age group was 30-39 years (35.51%) in replacement donors and 20-29 years (54.15%) in first time non-remunerated donors. Male gender was significantly predominant (73.00% men vs 27.00% women, P<10(-6)). There were significantly more men among replacement donors (82.27% vs 55.38%, P<10(-3)). There were more women in the age groups 18-19 and 20-29 years. Only one HIV seropositive donation was noted in a male first time non-remunerated donor aged 18. Replacement type of donation, male sex and age were three independent risk factors for the HBs Ag carriage. For anti-HCV antibodies and TPHA, only replacement type of donation and age were found out to be risk factors and only age was independent.


CONCLUSION
In Tunisia, replacement blood donors were at higher risk of infection transmission, but only for hepatitis B.
['Ben Jemia|R|R|', 'Gouider|E|E|']
D000293:Adolescent D000328:Adult D000367:Age Factors D000914:Antibodies, Viral D001782:Blood Donors D001803:Blood Transfusion D019353:Endemic Diseases D005190:Family D005260:Female D015658:HIV Infections D006509:Hepatitis B D006526:Hepatitis C D006801:Humans D008297:Male D008875:Middle Aged D060926:Remuneration D012189:Retrospective Studies D012307:Risk Factors D016036:Seroepidemiologic Studies D013587:Syphilis D013588:Syphilis Serodiagnosis D065227:Transfusion Reaction D014416:Tunisia D014766:Viremia D014838:Volunteers D055815:Young Adult
Replacement donors HIV Syphilis Blood donors Hepatitis Donneurs de compensation Donneurs de sang Donneurs volontaires Hépatite Infections transmises par transfusion Transfusion-transmitted disease VIH Volunteer donors