The Special Developmental Biology of Craniofacial Tissues Enables the Understanding of Oral and Maxillofacial Physiology and Diseases.
Maxillofacial hard tissues have several differences compared to bones of other localizations of the human body. These could be due to the different embryological development of the jaw bones compared to the extracranial skeleton. In particular, the immigration of neuroectodermally differentiated cells of the cranial neural crest (CNC) plays an important role. These cells differ from the mesenchymal structures of the extracranial skeleton. In the ontogenesis of the jaw bones, the development via the intermediate stage of the pharyngeal arches is another special developmental feature. The aim of this review was to illustrate how the development of maxillofacial hard tissues occurs via the cranial neural crest and pharyngeal arches, and what significance this could have for relevant pathologies in maxillofacial surgery, dentistry and orthodontic therapy. The pathogenesis of various growth anomalies and certain syndromes will also be discussed.
['Weber|Manuel|M|0000-0002-8649-5977', 'Wehrhan|Falk|F|', 'Deschner|James|J|', 'Sander|Janina|J|', 'Ries|Jutta|J|', 'Möst|Tobias|T|', 'Bozec|Aline|A|0000-0001-8174-2118', 'Gölz|Lina|L|', 'Kesting|Marco|M|', 'Lutz|Rainer|R|']
D001934:Branchial Region D002454:Cell Differentiation D002465:Cell Movement D005147:Facial Bones D018507:Gene Expression Regulation, Developmental D006801:Humans D008445:Maxillofacial Development D009432:Neural Crest D015398:Signal Transduction
developmental biology cranial neural crest orthodontics maxillofacial development