Comparison of virtual bronchoscopy to fiber-optic bronchoscopy for assessment of inhalation injury severity.
PURPOSE
Compare virtual bronchoscopy (VB) to fiberoptic bronchoscopy (FOB) for scoring smoke inhalation injury (SII).


METHODS
Swine underwent computerized tomography (CT) with VB and FOB before (0) and 24 and 48 h after SII. VB and FOB images were scored by 5 providers off line.


RESULTS
FOB and VB scores increased over time (p<0.001) with FOB scoring higher than VB at 0 (0.30±0.79 vs. 0.03±0.17), 24 h (4.21±1.68 vs. 2.47±1.50), and 48h (4.55±1.83 vs. 1.94±1.29). FOB and VB showed association with PaO2-to-FiO2 ratios (PFR) with areas under receiver operating characteristic curves (ROC): for PFR≤300, VB 0.830, FOB 0.863; for PFR≤200, VB 0.794, FOB 0.825; for PFR≤100, VB 0.747, FOB 0.777 (all p<0.001). FOB showed 80.3% specificity, 77% sensitivity, 88.8% negative-predictive value (NPV), and 62.3% positive-predictive value (PPV) for PFR≤300 and VB showed 67.2% specificity, 85.5% sensitivity, 91.3% NPV, and 53.4% PPV.


CONCLUSIONS
VB provided similar injury severity scores to FOB, correlated with PFR, and reliably detected airway narrowing. VB performed during admission CT may be a useful screening tool specifically to demonstrate airway narrowing induced by SII.
['Kwon|Herbert P|HP|', 'Zanders|Thomas B|TB|', 'Regn|Dara D|DD|', 'Burkett|Samuel E|SE|', 'Ward|John A|JA|', 'Nguyen|Ruth|R|', 'Necsoiu|Corina|C|', 'Jordan|Bryan S|BS|', 'York|Gerald E|GE|', 'Jimenez|Santiago|S|', 'Chung|Kevin K|KK|', 'Cancio|Leopoldo C|LC|', 'Morris|Michael J|MJ|', 'Batchinsky|Andriy I|AI|']
D000818:Animals D001999:Bronchoscopy D005260:Female D008168:Lung D012680:Sensitivity and Specificity D012720:Severity of Illness Index D015208:Smoke Inhalation Injury D013552:Swine D014057:Tomography, X-Ray Computed
Virtual bronchoscopy Fiber-optic bronchoscopy Inhalation injury Swine Computed tomography scan