Effects of coronary artery disease in patients undergoing transcatheter aortic valve implantation: A study of age- and gender-matched cohorts.
BACKGROUND
The prognostic role of concomitant coronary artery disease (CAD) among patients undergoing transcatheter aortic valve implantation (TAVI) is still uncertain.


METHODS
Data from the Bern TAVI Registry and the Bern PCI Registry were analyzed. Patients with concomitant CAD undergoing TAVI (TAVI+CAD) were age- and gender-matched to the following two cohorts: patients without CAD undergoing TAVI (TAVI-noCAD) and patients with stable CAD undergoing percutaneous coronary intervention (CAD-noAS). Major adverse cardiovascular and cerebrovascular events (MACCE), defined as the composite of cardiovascular death, myocardial infarction, or cerebrovascular events, represented the primary endpoint at 1-year.


RESULTS
Out of 9478 procedures performed between 2007 and 2013 (807 TAVI; 8671 PCI), three cohorts, each including 248 subjects, were derived. At 1-year, MACCE were significantly increased among TAVI+CAD compared with TAVI-noCAD (16.8% vs. 9.8%, hazard ratio, HR, 1.75, 95% confidence intervals, CI, 1.06-2.89, p=0.030) and CAD-noAS patients (16.8% vs. 9.5%, HR 1.85, 95%CI 1.11-3.09, p=0.018) whereas no difference was found between TAVI-noCAD and CAD-noAS patients. The higher rate of MACCE among TAVI+CAD patients was mainly driven by an increased risk of cardiovascular mortality compared with the TAVI-noCAD (HR 1.86, 95%CI 1.03-3.36, p=0.040) and CAD-noAS cohorts (HR 2.29, 95%CI 1.22-4.30, p=0.010). The 1-year rate of MACCE was similar between TAVI-noCAD and CAD-noAS patients (9.8% vs. 9.5%, HR 1.05, 95%CI 0.59-1.87, p=0.86).


CONCLUSIONS
Concomitant CAD in the setting of TAVI conveyed an increased risk of ischemic events and cardiovascular mortality at 1-year follow-up.
['Franzone|Anna|A|', 'Stortecky|Stefan|S|', 'Räber|Lorenz|L|', 'Heg|Dik|D|', 'Yamaji|Kyohei|K|', 'Piccolo|Raffaele|R|', 'Asami|Masahiko|M|', 'Lanz|Jonas|J|', 'Praz|Fabien|F|', 'Koskinas|Kostantinos|K|', 'Zanchin|Thomas|T|', 'Wenaweser|Peter|P|', 'Valgimigli|Marco|M|', 'Jüni|Peter|P|', 'Pilgrim|Thomas|T|', 'Windecker|Stephan|S|']
D000367:Age Factors D000368:Aged D000369:Aged, 80 and over D015331:Cohort Studies D003324:Coronary Artery Disease D003643:Death D005260:Female D005500:Follow-Up Studies D006801:Humans D008297:Male D011446:Prospective Studies D012042:Registries D012307:Risk Factors D012737:Sex Factors D065467:Transcatheter Aortic Valve Replacement
Coronary artery disease Transcatheter aortic valve implantation Mortality Prognosis