Synthesis of Natural Homoisoflavonoids Having Either 5,7-Dihydroxy-6-methoxy or 7-Hydroxy-5,6-dimethoxy Groups.
Naturally occurring homoisoflavonoids containing either 5,7-dihydroxy-6-methoxy or 7-hydroxy-5,6-dimethoxy groups such as the antiangiogenic homoisoflavanone, cremastranone, were synthesized via three or four linear steps from the known 4-chromenone. This facile synthesis includes chemoselective 1,4-reduction of 4-chromenone and selective deprotection of 3-benzylidene-4-chromanone a containing C7-benzyloxy group.
['Lee|Hyungjun|H|', 'Yuan|Yue|Y|', 'Rhee|Inmoo|I|', 'Corson|Timothy W|TW|', 'Seo|Seung-Yong|SY|']
D001688:Biological Products D007529:Isoflavones D009682:Magnetic Resonance Spectroscopy D015394:Molecular Structure
homoisoflavanone cremastranone 4-chromanone 4-chromenone 1,4-reduction