Volatile organic compounds (VOCs) fingerprint of Alzheimer's disease.
Alzheimer's disease (AD) is a profoundly life changing condition and once diagnosis occurs, this is typically at a relatively late stage into the disease process. Therefore, a shift to earlier diagnosis, which means several decades before the onset of the typical manifestation of the disease, will be an important step forward for the patient. A promising diagnostic and screening tool to answer this purpose is represented by breath and exhaled volatile organic compounds (VOCs) analysis. In fact, human exhaled breath contains several thousand of VOCs that vary in abundance and number in correlation with the physiological status. The exhaled VOCs reflect the metabolism, including the neuronal ones, in healthy and pathological conditions. A growing number of studies clearly demonstrate the effectiveness of VOCs analysis in identifying pathologies, including neurodegenerative diseases. In the present study we recorded, in real time, breath parameters and exhaled VOCs. We were able to demonstrate a significant alteration in breath parameters induced by the pathology of AD. Further, we provide the putative VOCs fingerprint of AD. These vital findings are an important step toward the early diagnosis of AD.
['Mazzatenta|Andrea|A|', 'Pokorski|Mieczyslaw|M|', 'Sartucci|Ferdinando|F|', 'Domenici|Luciano|L|', 'Di Giulio|Camillo|C|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D000544:Alzheimer Disease D015415:Biomarkers D001944:Breath Tests D006801:Humans D008875:Middle Aged D056152:Respiratory Rate D013997:Time Factors D055549:Volatile Organic Compounds D055815:Young Adult
Volatile organic compounds (VOCs) Alzheimer's disease Neurodegenerative disease VOC fingerprint Breath analysis VOC real time analysis