The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration.
Hesperetin has been suggested to be involved in bone strength. We aimed to investigate the effects of hesperetin on the osteogenic differentiation of human mesenchymal stem cells and its related mechanisms. We showed that hesperetin promoted osteogenic differentiation of human mesenchymal stem cells in vitro. It potentially exerts its effects via the ERK and Smad signaling pathways. Using a rat osteotomy model, we showed that human mesenchymal stem cells combined with a hesperetin/gelatin sponge scaffold resulted in accelerated fracture healing in vivo. Due to the low cost of hesperetin, it could be used as a growth factor for bone tissue engineering or surgical fracture treatment.
['Xue|Deting|D|', 'Chen|Erman|E|', 'Zhang|Wei|W|', 'Gao|Xiang|X|', 'Wang|Shengdong|S|', 'Zheng|Qiang|Q|', 'Pan|Zhijun|Z|', 'Li|Hang|H|', 'Liu|Ling|L|']
D000818:Animals D017209:Apoptosis D001861:Bone Regeneration D002454:Cell Differentiation D002465:Cell Movement D049109:Cell Proliferation D002478:Cells, Cultured D006569:Hesperidin D006801:Humans D008297:Male D059630:Mesenchymal Stem Cells D010012:Osteogenesis D010766:Phosphorylation D051381:Rats D017207:Rats, Sprague-Dawley D015398:Signal Transduction D023822:Tissue Engineering
hesperetin osteogenesis mesenchymal stem cells bone regeneration gelatin sponge scaffold