Effects of BDE-209 and its mixtures with BDE-47 and BDE-99 on multiple biomarkers in Carassius auratus.
In the present study, the sublethal effects of BDE-209 and its mixtures with BDE-47 and BDE-99 on goldfish (Carassius auratus) were investigated, and the biomarkers including acetylcholinesterase (AChE) in brain, catalase (CAT), ethoxyresorufin-O-deethylase (EROD), glutathione-S-transferase (GST) and superoxide dismutase (SOD) in liver were determined after 4 days of exposure. AChE and CAT activities were significantly inhibited by BDE-209 and the mixtures at higher dosages (≥1mg/kg), and exhibited obvious dose-response relationships. EROD, GST and SOD activities were significantly induced by BDE-209 and the mixtures in most cases. Integrated biomarker response (IBR) was calculated by combining multiple biomarkers to single value and used to quantitatively evaluate the toxicological effects of PBDEs. The order of IBR values was BDE-209/BDE-99>BDE-209/BDE-99/BDE-47>BDE-209/BDE-47>BDE-209. It suggests that IBR might be a useful tool for quantification of integrated biological effects induced by coexisted contaminants toward fish.
['Xie|Zhengxin|Z|', 'Lu|Guanghua|G|', 'Qi|Pengde|P|']
D000110:Acetylcholinesterase D000818:Animals D015415:Biomarkers D001921:Brain D002374:Catalase D019363:Cytochrome P-450 CYP1A1 D004305:Dose-Response Relationship, Drug D029941:Fish Proteins D015971:Gene Expression Regulation, Enzymologic D006054:Goldfish D055768:Halogenated Diphenyl Ethers D008099:Liver D013482:Superoxide Dismutase D014874:Water Pollutants, Chemical
BDE-209 Biomarker Carassius auratus IBR