Molecular self assembly of mixed comb-like dextran surfactant polymers for SPR virus detection.
The synthesis of two comb-like dextran surfactant polymers, that are different in their dextran molecular weight (MW) distribution and the presence of carboxylic groups, and their characterization are reported. A bimodal carboxylic dextran surfactant polymer consists of poly(vinyl amine) (PVAm) backbone with carboxyl higher MW dextran, non-functionalized lower MW dextran and hydrophobic hexyl branches; while a monomodal dextran surfactant polymer is PVAm grafted with non-functionalized lower MW dextran and hexyl branches. Layer formation of non-covalently attached dextran chains with bimodal MW distributions on a surface plasmon resonance (SPR) chip was investigated from the perspective of mixed physisorption of the bimodal and monomodal surfactant polymers. Separation distances between the carboxylic longer dextran side chains within the bimodal surfactant polymer and between the whole bimodal surfactant molecules on the chip surface could be well-controlled. SPR analysis of shrimp yellow head virus using our mixed surfactant chips showed dependence on synergetic adjustment of these separation distances.
['Mai-Ngam|Katanchalee|K|', 'Kiatpathomchai|Wansika|W|', 'Arunrut|Narong|N|', 'Sansatsadeekul|Jitlada|J|']
D000818:Animals D003911:Dextrans D057927:Hydrophobic and Hydrophilic Interactions D018625:Microscopy, Atomic Force D008970:Molecular Weight D033561:Penaeidae D046828:Roniviridae D020349:Surface Plasmon Resonance D013501:Surface-Active Agents
Dextran surfactant polymer Virus Surface plasmon resonance Bimodal molecular weight distribution