Structurally diverse triterpenoids with cytotoxicity from Euphorbia hypericifolia.
Extensive phytochemical investigation on the whole herbs of Euphorbia hypericifolia led to the isolation of 18 structurally diverse tetracyclic and pentacyclic triterpenoids, including four 4α,14α-dimethyl-5α-ergostanes (1-4), two seco-adiananes (5 and 6), three dammaranes (7-9), four cycloartanes (10-13), one tirucallane (14), two fernanes (15 and 16), one ursane (17), and one oleanane (18). Among them, euphypenoids A (1) and B (5) were new triterpenoids. Their structures were elucidated on the basis of extensive spectroscopic analysis, single-crystal X-ray diffraction, and chemical transformation. All isolates were screened for their cytotoxic activities against the colorectal cancer cell line HCT-116, and compounds 1, 12, and 15 showed remarkable activities with IC50 values of 12.8 ± 1.6, 7.4 ± 0.2, and 10.6 ± 1.2 μM, respectively.
['Hu|Rong|R|', 'Sang|Jun|J|', 'Li|Wei|W|', 'Tian|Yang|Y|', 'Zou|Ming-Feng|MF|', 'Tang|Gui-Hua|GH|', 'Yin|Sheng|S|']
D000972:Antineoplastic Agents, Phytogenic D002681:China D028481:Euphorbia D045325:HCT116 Cells D006801:Humans D015394:Molecular Structure D064209:Phytochemicals D014315:Triterpenes
Triterpenoid Cytotoxicity Euphorbia hypericifolia Single-crystal X-ray diffraction