The ClpXP Protease Contributes to Staphylococcus aureus Pneumonia.
Staphylococcus aureus is a leading cause of pneumonia. We show here that the ClpXP protease involved in protein turnover is important for pathogenesis in a murine model of acute pneumonia. Staphylococcus aureus lacking this protease is attenuated in vivo, being rapidly cleared from the airway and leading to decreased immune cell influx and inflammation. Characterization of defined mutations in vitro identified defects in intracellular survival and protection against neutrophil killing. Our results further expand on what is known about ClpXP in the pathogenesis of S. aureus to include the respiratory tract.
['Kim|Gyu-Lee|GL|', 'Akoolo|Lavoisier|L|', 'Parker|Dane|D|']
D000818:Animals D001426:Bacterial Proteins D004195:Disease Models, Animal D049071:Endopeptidase Clp D005260:Female D054884:Host-Pathogen Interactions D007249:Inflammation D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D050296:Microbial Viability D009154:Mutation D009504:Neutrophils D011023:Pneumonia, Staphylococcal D013211:Staphylococcus aureus
ClpXP Staphylococcus aureus pneumonia inflammation neutrophils ClpP ClpX host–pathogen interactions lung