Predictors of abnormality in thallium myocardial perfusion scans for type 2 diabetes.
Type 2 diabetes mellitus (T2DM) increases coronary artery disease (CAD) risk. In this study, we used T2DM clinical variables to predict abnormality in thallium-201 myocardial perfusion scans (Th-201 scans). These clinical variables were summed stress score (SSS), summed rest score, and summed difference score (SDS), with data obtained from 368 male and 428 female participants with T2DM. Multiple linear regression results were as follows. In male participants, body mass index (BMI) and creatinine (Cr) were associated with SSS (β = 0.224, p < 0.001; β = 0.140, p = 0.022, respectively), and only BMI was associated with SDS (β = 0.174, p = 0.004). In female participants, BMI and high-density lipoprotein cholesterol level were associated with SSS (β = 0.240, p < 0.001; β =  - 0.120, p = 0.048, respectively), and only BMI was correlated with SDS (β = 0.123, p = 0.031). Our multivariate logistic regression indicated that in male and female participants, BMI was the only independent indicator of high SSS (SSS ≥ 9). In this study, we demonstrated that male patients have a higher SSS and SDS than female patients do in Th-201 scans for T2DM in a Chinese population. For male and female patients, BMI was the strongest predictor of abnormality in Th-201 scans. Our results can help clinicians identify patients with T2DM at high risk of CAD.
['Lu|Chieh-Hua|CH|', 'Pei|Dee|D|', 'Wu|Chung-Ze|CZ|', 'Kua|Hui-Chun|HC|', 'Liang|Yao-Jen|YJ|', 'Chen|Yen-Lin|YL|', 'Lin|Jiunn-Diann|JD|http://orcid.org/0000-0002-9444-8249']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D003324:Coronary Artery Disease D003326:Coronary Circulation D003924:Diabetes Mellitus, Type 2 D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D055414:Myocardial Perfusion Imaging D011379:Prognosis D012189:Retrospective Studies D013794:Thallium Radioisotopes
Type 2 diabetes mellitus Coronary artery disease Summed stress score Summed difference score Thallium 201 scan