Antitumor potential of carrageenans from marine red algae.
Marine algae are abundant and inexhaustive sources of the bioactive compounds with the various benefits for human health. Among these substances an attention is given to the sulfated polysaccharides presented as the complexes of polymer macromolecules with excellent biological features including antioxidant, anti-inflammatory anticoagulant, antiviral, and immunomodulatory activities. In addition to the aforementioned properties there is a growing number of research results suggesting the bioactive sulfated polysaccharides such as carrageenan, fucoidan, laminarin, and others exert anticancer and antimetastatic properties. The present review contains the main results of experimental studies of the carrageenan anticancer activity including systemic and intracellular mechanisms of the antiproliferative influence. Relationships between structure, physico-chemical properties of carrageenan and their antitumor effects are described. There are data on the toxicology and pharmacokinetics of carrageenans as well as other aspects of their pharmacotherapeutic and pharmacoprophylactic influence that allow considering them as the potential anticancer agents.
['Khotimchenko|Maxim|M|', 'Tiasto|Vladlena|V|', 'Kalitnik|Aleksandra|A|', 'Begun|Maria|M|', 'Khotimchenko|Rodion|R|', 'Leonteva|Ekaterina|E|', 'Bryukhovetskiy|Igor|I|', 'Khotimchenko|Yuri|Y|']
D000276:Adjuvants, Immunologic D000818:Animals D000970:Antineoplastic Agents D000975:Antioxidants D019496:Cancer Vaccines D002351:Carrageenan D059447:Cell Cycle Checkpoints D045744:Cell Line, Tumor D049109:Cell Proliferation D006801:Humans D051379:Mice D010936:Plant Extracts D000461:Rhodophyta D012624:Seaweed D013329:Structure-Activity Relationship
Carrageenans Marine algae Sulfated polysaccharides Anticancer agents Rhodophyta