Lack of association between cystatin C and different coronary atherosclerotic manifestations.
Cystatin C (CysC) is known to be related to cardiovascular disease (CVD), including the presence and severity of coronary artery disease (CAD) and future clinical events. In this study, the association between CysC levels and (1) coronary artery calcification (CAC) in asymptomatic individuals from the general population as well as (2) different subgroups of patients with suspected or definite acute myocardial infarction (MI) was investigated. CysC levels were measured in serum from asymptomatic individuals as part of a screening study for CAC using non-contrast cardiac CT scan (N = 1039) as well as in subgroups of hospitalized patients with a suspected MI (N = 769). CysC was not associated with CAC in asymptomatic individuals after adjusting for relevant risk factors. No difference in CysC levels was observed between patients with type 1 MI (1.07 mg/L) and patients with normal troponin (with or without prior CAD: 1.14 and 1.01 mg/L, respectively). However, patients with type 2 MI and patient subgroups with elevated troponin but without MI had significantly higher CysC levels (1.24, 1.23 and 1.31 mg/L), even after adjusting for other risk factors. CysC was not associated with CAC in middle-aged asymptomatic individuals from the general population. Furthermore, CysC levels were found to be significantly lower in patients with type 1 MI compared to patients with type 2 MI and patients with elevated troponins but without MI. Thus, in two independent and clinically different populations, no association between CysC and coronary atherosclerotic manifestations could be demonstrated.
['Larsen|Trine R|TR|', 'Gerke|Oke|O|', 'Diederichsen|Axel C P|ACP|', 'Lambrechtsen|Jess|J|', 'Steffensen|Flemming Hald|FH|', 'Sand|Niels Peter|NP|', 'Antonsen|Steen|S|', 'Mickley|Hans|H|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D050197:Atherosclerosis D015415:Biomarkers D016022:Case-Control Studies D003324:Coronary Artery Disease D003430:Cross-Sectional Studies D055316:Cystatin C D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D009203:Myocardial Infarction D055815:Young Adult
Cystatin C coronary artery disease myocardial infarction atherosclerosis myocardial ischaemia troponins and cardiac biomarkers vascular calcification