Influenza A(H1N1)pdm09 virus exhibiting reduced susceptibility to baloxavir due to a PA E23K substitution detected from a child without baloxavir treatment.
Human-to-human transmission of PA I38 mutant influenza A(H3N2) viruses with reduced baloxavir susceptibility has been reported in Japan. In December 2019, we detected a PA E23K mutant A(H1N1)pdm09 virus from a child without baloxavir treatment. The PA E23K mutant virus exhibited reduced baloxavir susceptibility but remained susceptible to neuraminidase inhibitors. Epidemiological data suggest possible transmission of this PA E23K mutant virus among humans, although its growth capability relative to that of the wild-type virus was reduced. Therefore, baloxavir susceptibility monitoring of influenza viruses is essential.
['Takashita|Emi|E|', 'Abe|Takashi|T|', 'Morita|Hiroko|H|', 'Nagata|Shiho|S|', 'Fujisaki|Seiichiro|S|', 'Miura|Hideka|H|', 'Shirakura|Masayuki|M|', 'Kishida|Noriko|N|', 'Nakamura|Kazuya|K|', 'Kuwahara|Tomoko|T|', 'Mitamura|Keiko|K|', 'Ichikawa|Masataka|M|', 'Yamazaki|Masahiko|M|', 'Watanabe|Shinji|S|', 'Hasegawa|Hideki|H|', '|||']
D019943:Amino Acid Substitution D000818:Animals D000998:Antiviral Agents D002648:Child D003988:Dibenzothiepins D004285:Dogs D024882:Drug Resistance, Viral D006801:Humans D053118:Influenza A Virus, H1N1 Subtype D007251:Influenza, Human D007564:Japan D061985:Madin Darby Canine Kidney Cells D009025:Morpholines D011728:Pyridones D014227:Triazines D014764:Viral Proteins
Influenza Baloxavir Cap-dependent endonuclease inhibitor Resistance