Fatal Familial Insomnia Initially Developing Parkinsonism Mimicking Dementia with Lewy Bodies.
We report a rare case of fatal familial insomnia in a 58-year-old man who initially developed parkinsonism, secondary dementia, and visual hallucinations that were suspected to be due to dementia with Lewy bodies. We evaluated the function of the striatum via dopamine transporter single-photon emission computed tomography (DAT SPECT) using 123I-ioflupane and found marked presynaptic dopamine dysfunction in the bilateral striatum. This is the first reported case in which the initial symptom of fatal familial insomnia was parkinsonism and in which the dopamine transporter function was evaluated by DAT SPECT.
['Fukuoka|Takuya|T|', 'Nakazato|Yoshihiko|Y|', 'Yamamoto|Masaomi|M|', 'Miyake|Akifumi|A|', 'Mitsufuji|Takashi|T|', 'Yamamoto|Toshimasa|T|']
D003342:Corpus Striatum D003937:Diagnosis, Differential D050483:Dopamine Plasma Membrane Transport Proteins D006212:Hallucinations D006801:Humans D034062:Insomnia, Fatal Familial D020961:Lewy Body Disease D008297:Male D008875:Middle Aged D020734:Parkinsonian Disorders D015899:Tomography, Emission-Computed, Single-Photon
fatal familial insomnia parkinsonism DAT SPECT