Glucocorticoid receptor in cervical cancer: an immunhistochemical analysis.
PURPOSE
Cervical cancer is one of the most frequent cancers in women worldwide. In most of all cases, a persistent HPV infection is the leading cause. HPV-specific sequences are able to bind glucocorticoid receptor (GR). Dexamethasone can increase the activity of early promoters in HPV16 and HPV18 interfering in transcription control of viral oncogenes. The aim of our study was to evaluate glucocorticoid receptor as transcriptional factor in its active form in the nucleus of in cervical cancer cells and to correlate the results with clinical patient specific parameters.


METHODS
A total of 250 paraffin-embedded cervical cancer samples obtained from patients having undergone surgery for cervical cancer were used for the study. The expression of GR was immunhistochemical examined and evaluated by a semi-quantitative scoring. SPSS software was used for the statistical evaluation of staining results and survival analysis of patients with cervical cancer.


RESULTS
GR is frequently expressed in cervical carcinoma tissue in favor of squamous cell carcinoma (SCC). An enhanced expression is correlated with rather small clinical stages. The expression of the GR is correlated with better overall survival and progression-free survival.


CONCLUSIONS
The glucocorticoid receptor is frequently expressed in cervical carcinoma tissue in favor of squamous cell carcinoma. An enhanced expression is correlated with rather small clinical stages. The expression of the analyzed receptor is correlated with better overall survival. Further studies are needed to determine useful treatment targets for glucocorticoid receptor manipulation.
['Kost|Bernd Peter|BP|', 'Beyer|Susanne|S|', 'Schröder|Lennard|L|', 'Zhou|Junyan|J|', 'Mayr|Doris|D|', 'Kuhn|Christina|C|', 'Schulze|Sandra|S|', 'Hofmann|Simone|S|', 'Mahner|Sven|S|', 'Jeschke|Udo|U|0000-0003-2623-3235', 'Heidegger|Helene|H|']
D000328:Adult D002294:Carcinoma, Squamous Cell D018290:Cervical Intraepithelial Neoplasia D005260:Female D052162:Human papillomavirus 16 D006801:Humans D008875:Middle Aged D030361:Papillomavirus Infections D016612:Paraffin Embedding D011401:Promoter Regions, Genetic D011965:Receptors, Glucocorticoid D016019:Survival Analysis D014158:Transcription, Genetic D002583:Uterine Cervical Neoplasms
Glucocorticoid receptor Cervical cancer Survival