Linking GABA and glutamate levels to cognitive skill acquisition during development.
Developmental adjustments in the balance of excitation and inhibition are thought to constrain the plasticity of sensory areas of the cortex. It is unknown however, how changes in excitatory or inhibitory neurochemical expression (glutamate, γ-aminobutyric acid (GABA)) contribute to skill acquisition during development. Here we used single-voxel proton magnetic resonance spectroscopy (1H-MRS) to reveal how differences in cortical glutamate vs. GABA ratios relate to face proficiency and working memory abilities in children and adults. We show that higher glutamate levels in the inferior frontal gyrus correlated positively with face processing proficiency in the children, but not the adults, an effect which was independent of age-dependent differences in underlying cortical gray matter. Moreover, we found that glutamate/GABA levels and gray matter volume are dissociated at the different maturational stages. These findings suggest that increased excitation during development is linked to neuroplasticity and the acquisition of new cognitive skills. They also offer a new, neurochemical approach to investigating the relationship between cognitive performance and brain development across the lifespan.
['Cohen Kadosh|Kathrin|K|', 'Krause|Beatrix|B|', 'King|Andrew J|AJ|', 'Near|Jamie|J|', 'Cohen Kadosh|Roi|R|']
D000328:Adult D002648:Child D002657:Child Development D000066499:Facial Recognition D018698:Glutamic Acid D066128:Gray Matter D006801:Humans D007858:Learning D008570:Memory, Short-Term D009473:Neuronal Plasticity D017397:Prefrontal Cortex D066244:Proton Magnetic Resonance Spectroscopy D055815:Young Adult D005680:gamma-Aminobutyric Acid
glutamate γ-aminobutyric acid magnetic resonance spectroscopy working memory face processing cognitive development cortical excitability