Prevalence, diagnosis and outcomes of treatment for primary aldosteronism.
Primary aldosteronism (PA) is the most common potentially curable form of hypertension. The overproduction of aldosterone leads to an increased risk of cardiovascular and cerebrovascular events as well as adverse effects to the heart and kidney and psychological disorders. PA is mainly caused by unilateral aldosterone excess due to an aldosterone-producing adenoma or bilateral excess due to bilateral adrenocortical hyperplasia. The diagnostic work-up of PA comprises three steps: screening, confirmatory testing and differentiation of unilateral surgically-correctable forms from medically treated bilateral PA. These specific treatments can mitigate or reverse the increased risks associated with PA. Herein we summarise the prevalence, outcomes and current and future clinical approaches for the diagnosis of primary aldosteronism.
['Yang|Yuhong|Y|', 'Reincke|Martin|M|', 'Williams|Tracy Ann|TA|']
D000310:Adrenal Gland Neoplasms D018246:Adrenocortical Adenoma D000450:Aldosterone D003940:Diagnostic Techniques, Endocrine D006801:Humans D006929:Hyperaldosteronism D006973:Hypertension D008403:Mass Screening D015995:Prevalence D011379:Prognosis D016896:Treatment Outcome
prevalence aldosterone aldosterone-producing adenoma adrenal venous sampling bilateral adrenal hyperplasia renin