Spectrum of Kidney Diseases in Patients With Hepatitis C Virus Infection.
OBJECTIVES
To study the pathologic spectrum of kidney diseases in patients with hepatitis C virus infection (HCV+).


METHODS
Native kidney biopsy specimens in HCV+ patients were reviewed.


RESULTS
A total of 9,836 native kidney biopsy specimens were evaluated from January 2007 to December 2016, of which 273 (2.8%) were from HCV+ patients, and of these, 115 (42.1%) had diagnoses consistent with HCV-associated glomerulonephritis (GN). Non-HCV-associated kidney diseases comprised most diagnoses (158 cases, 57.9%) including non-immune complex-mediated kidney diseases (127 cases, 46.5%) and other immune complex-mediated glomerular diseases (31 cases, 11.4%). Forty-one (40.6%) patients had HCV-associated GN among 101 HCV+ patients from 2007 to 2011 vs 74 (43.0%) patients with HCV-associated GN among 172 HCV+ patients from 2012 to 2016. HCV-associated GN showed five morphologic patterns: focal proliferative (5.2%), diffuse mesangial proliferative (50.4%), diffuse membranoproliferative (28.7%), proliferative GN with crescentic lesions (7.8%), and membranous patterns (7.8%).


CONCLUSIONS
We found a spectrum of pathologic changes in renal biopsy specimens of HCV+ patients, with most having diseases unrelated to HCV infection, HCV-associated GN showing five morphologic patterns, and availability of effective HCV antiviral therapy not yet resulting in major changes in the spectrum of kidney diseases in these patients.
['Guo|Shunhua|S|0000-0002-2594-7992', 'Kapp|Meghan E|ME|', 'Beltran|Diego M|DM|', 'Cardona|Cesar Y|CY|', 'Caster|Dawn J|DJ|', 'Reichel|Ronald R|RR|', 'Fogo|Agnes B|AB|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D002648:Child D005260:Female D005921:Glomerulonephritis D006526:Hepatitis C D006801:Humans D007668:Kidney D007674:Kidney Diseases D008297:Male D008875:Middle Aged D055815:Young Adult
Kidney disease HCV-associated glomerulonephritis Cryoglobulinemia Hepatitis C virus (HCV)