Role of Biomarkers and Biopsy in Hepatocellular Carcinoma.
Hepatocellular carcinoma (HCC) is increasing in prevalence and is the third leading cause of cancer-related death worldwide. Unlike other malignancies, HCC can be diagnosed with dynamic imaging with very high accuracy, and tissue diagnosis is not needed for cancer therapy. There is a unique role of established as well as developing biomarkers in diagnosis, prognosis, and management of HCC. Sequencing HCC tumors has yielded substantial insights into HCC tumor biology and has raised the possibility of precision oncology in which therapy decisions are guided by cancer genetics. However, it is not ready for prime time yet.
['Chen|Vincent L|VL|', 'Sharma|Pratima|P|']
D015415:Biomarkers D014408:Biomarkers, Tumor D001706:Biopsy D006528:Carcinoma, Hepatocellular D006801:Humans D000073890:Liquid Biopsy D008113:Liver Neoplasms D025202:Molecular Diagnostic Techniques D037121:Plant Lectins D057285:Precision Medicine D011379:Prognosis D011498:Protein Precursors D011516:Prothrombin D000509:alpha-Fetoproteins
Sequencing AFP AFP-L3 DCP Liquid biopsy PIVKA-II