Fanconi anemia and vaginal squamous cell carcinoma.
Fanconi Anemia (FA) is an autosomal recessive disease characterized by chromosome instability, cellular hypersensitivity to DNA cross-linking agents, and increased predisposition to malignancies. We describe here a 28 year-old female with FA and vaginal squamous cell carcinoma treated by radiation therapy alone. The patient developed arm phlebitis, pulmonary fungal infection, and severe rectal bleeding, followed by hypocalcaemia, hypokalemia, vaginal bacterial and fungal infection, with subsequent leg and arm phlebitis, perineal abscess, and sepsis. The patient died 12 weeks later.
['Dias|Altamiro Ribeiro|AR|', 'de Andrade Silva|Marcela Cavalcante|MC|', 'Carvalho|Filomena Marino|FM|', 'de Andrade Carvalho|Heloisa|H|', 'Esteves Diz|Maria Del Pilar|Mdel P|', 'Baracat|Edmund Chada|EC|', 'Carvalho|Jesus Paula|JP|']
Fanconi anemia vaginal squamous cell carcinoma radiation therapy hemorrhage. proctitis