Decursin inhibits the growth of HeLa cervical cancer cells through PI3K/Akt signaling.
Decursin, a coumarin compound isolated from Angelica gigas has been shown to possess multiple anti-tumor activities. But it's still little known about the effects associated with cervical cancer. To explore the anti-tumor role of decursin and gain insights into its underlying mechanisms, we analyzed proliferation in parallel with apoptosis and migration in HeLa cells. Our findings implied that decursin can provoke apoptosis, and inhibit cell proliferation, migration in HeLa cells. More importantly, decursin also inhibited the tumor growth in vivo. The mechanisms may be associated with the regulation of Akt activation, with implications for novel therapeutic strategies on cervical cancer.[Formula: see text].
['Zhu|Meng-Lian|ML|', 'Li|Jian-Chun|JC|', 'Wang|Lu|L|', 'Zhong|Xia|X|', 'Zhang|Yu-Wei|YW|', 'Tan|Rui-Zhi|RZ|', 'Wang|Hong-Lian|HL|', 'Fan|Jun-Ming|JM|', 'Wang|Li|L|']
D017209:Apoptosis D001578:Benzopyrans D002087:Butyrates D049109:Cell Proliferation D005260:Female D006367:HeLa Cells D006801:Humans D015394:Molecular Structure D019869:Phosphatidylinositol 3-Kinases D051057:Proto-Oncogene Proteins c-akt D015398:Signal Transduction D002583:Uterine Cervical Neoplasms
Decursin cervical cancer proliferation apoptosis