Rose Petal Extract (Rosa gallica) Exerts Skin Whitening and Anti-Skin Wrinkle Effects.
We sought to investigate the effect of extracts from Rosa gallica petals (RPE) on skin whitening and anti-wrinkle activity. Tyrosinase activity was attenuated by RPE treatment, concomitant with the reduction of melanin accumulation in human B16F10 melanoma. Treatment of the facial skin of volunteers in a clinical trial with an RPE-containing formulation enhanced skin brightness (L* value) significantly. The underlying mechanism responsible was determined to be associated with mitogen-activated protein kinase (MAPK) activation. In addition, RPE exhibited anti-wrinkle formation activity of human dermal fibroblasts by suppressing matrix metalloproteinase (MMP)-1 level. In vivo study, RPE also inhibited solar ultraviolet-stimulated MMP-1 level by c-Jun regulation. Overall, our findings indicate that RPE evokes skin whitening and anti-wrinkle formation activity by regulating intracellular signaling, supporting its utility as an ingredient for skin whitening and anti-wrinkle cosmetic products.
['Song|Young-Ran|YR|', 'Lim|Won-Chul|WC|', 'Han|Ahram|A|', 'Lee|Myung-Hee|MH|', 'Shin|Eun Ju|EJ|', 'Lee|Kwang-Min|KM|', 'Nam|Tae-Gyu|TG|', 'Lim|Tae-Gyu|TG|']
D002478:Cells, Cultured D005347:Fibroblasts D006801:Humans D048031:JNK Mitogen-Activated Protein Kinases D020935:MAP Kinase Signaling System D020781:Matrix Metalloproteinase 1 D008543:Melanins D008546:Melanoma, Experimental D010936:Plant Extracts D027826:Rosa D012867:Skin D015595:Skin Aging D062327:Skin Lightening Preparations D014466:Ultraviolet Rays
melanin MMP-1 • Rosa gallica • skin whitening wrinkle formation