Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease.
We report a patient with connective tissue disease who developed modest severe acute respiratory syndrome coronavirus 2 receptor binding domain-specific antibody levels and a lack of neutralization capacity, despite having received 3 mRNA coronavirus disease 2019 vaccines and holding anti-B-cell therapy for >7 months before vaccination. The patient developed virus-specific T-cell responses.
['Peluso|Michael J|MJ|', 'Munter|Sadie E|SE|', 'Lynch|Kara L|KL|', 'Yun|Cassandra|C|https://orcid.org/0000-0002-6971-2060', 'Torres|Leonel|L|', 'Iyer|Nikita S|NS|', 'Donatelli|Joanna|J|', 'Ryan|Lindsay|L|', 'Deitchman|Amelia N|AN|', 'Deeks|Steven G|SG|', 'Rutishauser|Rachel L|RL|', 'Henrich|Timothy J|TJ|']
SARS-CoV-2 COVID-19 vaccine T-cell immunity neutralizing antibodies rheumatological disease