Favorable prognosis of biallelic CEBPA gene mutations in acute myeloid leukemia patients: a meta-analysis.
OBJECTIVES
Increasing number of studies suggested that biallelic CEBPA (bi CEBPA) mutations were associated with favorable prognosis in patients with acute myeloid leukemia (AML), but the results remain inconclusive. We therefore present a meta-analysis to evaluate the prognostic value of bi CEBPA mutations in patients with AML.


METHODS
A comprehensive literature search was undertaken through August 2014 looking for eligible studies. Pooled hazard ratios (HRs) estimates and 95% confidence intervals (95% CIs) in overall survival (OS) and event-free survival (EFS) were used to calculate estimated effect.


RESULTS
Ten studies covering a total of 6219 subjects were included in this analysis. Overall, bi CEBPA mutations were associated with favorable clinical outcome in patients with AML (HR for EFS: 0.41, 95% CI: 0.32-0.52; for OS: 0.37, 95% CI: 0.27-0.50), in cytogenetically normal (CN)-AML (HR for EFS: 0.38, 95% CI: 0.29-0.49; for OS: 0.32, 95% CI: 0.23-0.43). When took the cohort of monoallelic CEBPA (mo CEBPA) mutated and wild-type CEBPA (wt CEBPA) AML as a reference group, bi CEBPA mutated AML also shown beneficial outcomes (HR for OS: 0.52, 95% CI: 0.37-0.72). No significant difference was found between mo CEBPA mutation and wt CEBPA in patients with AML or CN-AML (P > 0.05).


CONCLUSION
Bi CEBPA mutations in patients with AML are strongly associated with a favorable prognosis, which suggested that bi CEBPA mutations would potentially serve as a novel prognostic marker in AML.
['Li|Hong-Ying|HY|', 'Deng|Dong-Hong|DH|', 'Huang|Ying|Y|', 'Ye|Fang-Hui|FH|', 'Huang|Lu-Lu|LL|', 'Xiao|Qiang|Q|', 'Zhang|Bing|B|', 'Ye|Bing-Bing|BB|', 'Lai|Yong-Rong|YR|', 'Mo|Zeng-Nan|ZN|', 'Liu|Zhen-Fang|ZF|']
D000483:Alleles D022762:CCAAT-Enhancer-Binding Proteins D005260:Female D015870:Gene Expression D006801:Humans D015470:Leukemia, Myeloid, Acute D008297:Male D009154:Mutation D011379:Prognosis D016019:Survival Analysis
prognosis Acute myeloid leukemia meta-analysis biallelic CEBPA mutations