Revisiting the Structure of Hemoglobin and Myoglobin with Cryo-Electron Microscopy.
Sixty years ago, the first protein structure of myoglobin was determined by John Kendrew and his colleagues; hemoglobin followed shortly thereafter. For quite some time, it seemed that only X-ray crystallography would be capable of determining the structure of proteins to high resolution. In recent years, cryo-electron microscopy has emerged as a viable alternative and indeed in many cases the preferred approach. It is capable of studying proteins that span a size range from several megadaltons to proteins as small as myoglobin and hemoglobin.
['Khoshouei|Maryam|M|', 'Danev|Radostin|R|', 'Plitzko|Juergen M|JM|', 'Baumeister|Wolfgang|W|']
D020285:Cryoelectron Microscopy D006454:Hemoglobins D009211:Myoglobin D011487:Protein Conformation
cryo-electron microscopy cryo-electron tomography