Association of sclerostin with cardiovascular events and mortality in dialysis patients.
Introduction: Sclerostin has been reported to be a novel biomarker associated with the bone-vascular axis. In this study, we determined the relationships between serum sclerostin and all-cause mortality, the prevalence of cardiovascular events (CVEs), and coronary artery calcifications (CACs) in dialysis patients.Methods: A total of 165 dialysis patients (84 hemodialysis [HD] and 81 peritoneal dialysis [PD]) were enrolled in this study. We performed multivariable linear regression analysis to test the relationships between serum sclerostin levels and demographics and clinical parameters. We also performed Cox proportional hazard regression analysis to determine independent predictors of overall survival and CVEs.Results: The median serum sclerostin level was 250.9 pg/mL in dialysis patients. Kaplan-Meier analysis showed that both overall and CVE-free survival rates were significantly lower in the high serum sclerostin group (serum sclerostin level >250.9 pg/mL) compared to the low serum sclerostin group (serum sclerostin level ≤250.9 pg/mL) in patients with PD (p < 0.05). In patients with HD, only CVE-free survival rates notably declined in the high serum sclerostin group compared to the low serum sclerostin group (p = 0.029). However, serum sclerostin level was only an independent predictor of all-cause mortality and CVEs in patients with PD after adjusting for confounding factors (p < 0.05), and therefore was not an independent predictor for patients with HD (p > 0.05).Conclusions: A low serum sclerostin was associated with better overall survival and lower prevalence of CVEs in patients with PD, but had no relationships in patients with HD. We found that serum sclerostin level was not correlated with CACs in either patients with HD or PD.
['Zou|Yun|Y|', 'Yang|Min|M|', 'Wang|Jiao|J|', 'Cui|Li|L|', 'Jiang|Zhenxing|Z|', 'Ding|Jiule|J|', 'Li|Min|M|', 'Zhou|Hua|H|']
D048868:Adaptor Proteins, Signal Transducing D000328:Adult D000368:Aged D002318:Cardiovascular Diseases D002681:China D005260:Female D006801:Humans D053208:Kaplan-Meier Estimate D008297:Male D008875:Middle Aged D015995:Prevalence D011446:Prospective Studies D012044:Regression Analysis D006435:Renal Dialysis D051436:Renal Insufficiency, Chronic D012307:Risk Factors D015996:Survival Rate
sclerostin mortality dialysis Cardiovascular diseases vascular calcification