The effect of daily caffeine exposure on lever-pressing for sucrose and c-Fos expression in the nucleus accumbens in the rat.
Recent reports suggest that caffeine exposure increases the motivation to consume drugs of abuse. As such, it may also enhance the motivation to consume palatable food. Because caffeine is a common constituent in over-the-counter weight-loss supplements, it is important to better understand the relationship between caffeine and food intake. The purpose of this study was to measure the effects of daily intermittent caffeine exposure on lever pressing for sucrose in rats and to assess the impact of caffeine on neuronal activation in the nucleus accumbens (NAc). Male Sprague-Dawley rats that received either saline or caffeine (1, 5, 20mg/kgi.p.) daily were tested on a fixed ratio 4 schedule for sucrose in operant chambers for 10days and then again following a 5-day treatment withdrawal period. After behavioral testing, a subset of the animals was sacrificed to measure the impact of caffeine on neuronal activation in the NAc using c-Fos as a marker. There was a significant increase in active lever presses for sucrose in the rats that had received 5mg/kg of caffeine when compared with the saline group. This treatment effect was no longer present after the withdrawal period. Acute, but not chronic, caffeine exposure elevated c-Fos expression in the NAc. These data suggest that intermittent daily caffeine exposure increases lever pressing for sucrose in rats, but leaves no lasting effect.
['Retzbach|Edward P|EP|', 'Dholakia|Paulomi H|PH|', 'Duncan-Vaidya|Elizabeth A|EA|']
D000818:Animals D002110:Caffeine D000697:Central Nervous System Stimulants D003216:Conditioning, Operant D008297:Male D009042:Motivation D009714:Nucleus Accumbens D016760:Proto-Oncogene Proteins c-fos D051381:Rats D017207:Rats, Sprague-Dawley D012055:Reinforcement Schedule D012646:Self Administration D013395:Sucrose
Caffeine Sucrose Nucleus accumbens Mesolimbic dopamine system