Frequency of Nerve Root Sleeve Cysts in Autosomal Dominant Polycystic Kidney Disease.
BACKGROUND
There is sporadic data about the occurrence of spinal meningeal cysts in patients with autosomal dominant polycystic kidney disease (ADPKD). We suggest that there is a relationship with the frequency and size of spinal meningeal cysts and headache, intracranial aneurysms, and cerebrospinal fluid leakage in patients with ADPKD.


AIM
To investigate the relationship with spinal meningeal cyst, cerebrospinal fluid leakage, and headache in patients with ADPKD.


STUDY DESIGN
Cross-sectional study.


METHODS
We enrolled 50 patients with ADPKD and 37 healthy volunteers. This cross-sectional study included patients with ADPKD and matched healthy volunteers. Magnetic resonance imaging myelography was performed using the 3D-T2 HASTE technique in an MRI scanner. We questioned our subjects regarding presence of headache and evaluated headache severity using a visual analog scale. The relationship between the number and size of spinal meningeal cysts with headache, intracranial aneurysms, and liver cysts was also investigated.


RESULTS
Spinal meningeal cysts were more numerous and larger in patients than in controls (14.8±11.6 vs. 6.4±4.6 cysts respectively, p<0.001, 68.3±49.3 vs. 25.4±20.1 mm, p<0.001, respectively). Spinal cyst number and size were similar in APDKD patients with or without intracranial aneurysms. Headache score was correlated with the size and number of spinal meningeal cysts. This was valid only in patients with ADPKD.


CONCLUSION
Abnormality involving the vessel wall in ADPKD may explain the increased number of spinal meningeal cysts in ADPKD. Moreover, leakage of cerebrospinal fluid secondary to spinal meningeal cyst may be responsible for recurrent severe headache by causing spontaneous intracranial hypotension in these patients.
['Aşık|Murat|M|', 'Tufan|Fatih|F|', 'Akpınar|Timur Selçuk|TS|', 'Akalın|Nilgül|N|', 'Ceyhan|Elvan|E|', 'Tunç|Necmeddin|N|', 'Hasıloğlu|Zehra Işık|ZI|', 'Altıparmak|Mehmet Rıza|MR|', 'Ecder|Tevfik|T|', 'Albayram|Sait|S|']
autosomal dominant polycystic kidney disease Spinal meningeal cysts headache