Ageing in patients with chronic HIV infection: impact of hypercoagulation.
Ageing is the result of biological events that progressively and irreversibly compromise the function of vital organs and eventually result in death. There is a general perception that ageing is accelerated in people living with HIV, with an increasing body of evidence to support this view. With the introduction of effective antiretroviral therapy, the life expectancy of people living with HIV has improved. Since people with HIV are living longer than previously, while also ageing faster than the general population, there is an increase in HIV-positive patients living with age-related comorbidities. This brief overview of ageing and HIV discusses aspects of the complications of HIV infection as they impact the ageing process. How diseases of age affect patients with HIV provides clues to help unravel the interactions between HIV and ageing that ultimately should help clinicians understand the basis of 'normal' ageing and manage ageing HIV-positive patients more effectively.
['Kent|Stephen J|SJ|', 'Flexner|Charles|C|']
D000375:Aging D015415:Biomarkers D001777:Blood Coagulation D002908:Chronic Disease D015897:Comorbidity D015658:HIV Infections D006801:Humans D018836:Inflammation Mediators D008017:Life Expectancy
Ageing HIV Antiretroviral therapy Coagulation Fraility Inflammation