snoRNAs associate with mRNA 3' processing complex: New wine in old bottles.
3' end processing is required for the maturation of all eukaryotic RNAs. Current model suggests that canonical mRNA 3' processing is carried out exclusively within a protein complex termed mRNA 3' processing complex. In a recent study, by using RNA-biotin based pull-down assay and high-throughput sequencing, we reported that a subset of small nucleolar RNAs (snoRNAs) were physically associated with this macromolecular machinery. Through detailed characterization of one of these snoRNAs, SNORD50A, we revealed that non-coding RNA, such as snoRNA, may play a regulatory role in mRNA 3' processing. Our results provided novel insight into both the regulatory mechanism of mRNA 3' processing and the non-canonical functions of snoRNAs.
['Shi|Junjie|J|', 'Huang|Chunliu|C|', 'Huang|Shanshan|S|', 'Yao|Chengguo|C|0000-0001-9224-0156']
D020413:3' Untranslated Regions D000818:Animals D059014:High-Throughput Nucleotide Sequencing D006801:Humans D012333:RNA, Messenger D020537:RNA, Small Nucleolar D017423:Sequence Analysis, RNA
snoRNA cleavage mRNA 3′ processing polyadenylation