Morphologic investigation on Perceval S, a sutureless pericardial valve prosthesis: collagen integrity after collapsing-ballooning and structural valve deterioration at distance.
Perceval S is a self-expandable, stent-mounted bioprosthetic valve (BPV), with glutaraldehyde treated bovine pericardium, processed with homocysteic acid as an anti-calcification treatment. The stent is crimpable but the valve insertion is done surgically via a shorter procedure which does not require sutures. OBJECTIVES: MATERIAL AND METHODS: RESULTS: CONCLUSIONS: Collapsing and ballooning do not alter cusp collagen periodicity. Structural valve deterioration with stenosis, due to dystrophic calcification and fibrous tissue overgrowth, seldom occurred in the mid-term. Glutaraldehyde fixed pericardium has the potential to undergo structural valve deterioration with time, similar to well-known BPV failure. This supports the recommendation to pursue improvement of tissue valve treatment with enhanced durability.
['Bejko|Jonida|J|', 'Della Barbera|Mila|M|', 'Valente|Marialuisa|M|', 'Pettenazzo|Elena|E|', 'Gregori|Dario|D|', 'Basso|Cristina|C|', 'Thiene|Gaetano|G|']
D000818:Animals D001021:Aortic Valve D001705:Bioprosthesis D002114:Calcinosis D002417:Cattle D003094:Collagen D006350:Heart Valve Prosthesis D006801:Humans D010496:Pericardium D011474:Prosthesis Design D011475:Prosthesis Failure
Structural valve deterioration Bioprosthetic valves Collagen crimping