Clinical use of organic near-infrared fluorescent contrast agents in image-guided oncologic procedures and its potential in veterinary oncology.
One of the major challenges in surgical oncology is the intraoperative discrimination of tumoural versus healthy tissue. Until today, surgeons rely on visual inspection and palpation to define the tumoural margins during surgery and, unfortunately, for various cancer types, the local recurrence rate thus remains unacceptably high. Near-infrared (NIR) fluorescence imaging is an optical imaging technique that can provide real-time preoperative and intraoperative information after administration of a fluorescent probe that emits NIR light once exposed to a NIR light source. This technique is safe, cost-effective and technically easy. Several NIR fluorescent probes are currently studied for their ability to highlight neoplastic cells. In addition, NIR fluorescence imaging holds great promise for sentinel lymph node mapping. The aim of this manuscript is to provide a literature review of the current organic NIR fluorescent probes tested in the light of human oncology and to introduce fluorescence imaging as a valuable asset in veterinary oncology.
['Favril|Sophie|S|0000-0002-6684-5589', 'Abma|Eline|E|', 'Blasi|Francesco|F|', 'Stock|Emmelie|E|', 'Devriendt|Nausikaa|N|', 'Vanderperren|Katrien|K|', 'de Rooster|Hilde|H|']
D000818:Animals D003287:Contrast Media D004283:Dog Diseases D004285:Dogs D005456:Fluorescent Dyes D008495:Medical Oncology D009369:Neoplasms D009930:Organic Chemicals D019265:Spectroscopy, Near-Infrared D025321:Surgery, Computer-Assisted D014730:Veterinary Medicine
organic near-infrared fluorescent contrast agents sentinel lymph node mapping Near-infrared fluorescence imaging comparative oncology guided oncologic surgery