RETRACTED: Evaluation of amorphous debranched starch as extended-release matrices in tablets.
This study aims to investigate the physicochemical and extended-release properties of amorphous debranched starch (ADBS) that is a linear short chain amylose derived from pullulanase enzymatic modification. The results show the completely amorphous ADBS was soluble in cold water, which developed into a disordered gel network at 25 °C. ADBS based tablets were able to extend drug release in different media. Drug release, which was accelerated by decreased pH and pancreatin, was barely affected by ionic strength. The kinetics of the drug release process that was dominated by Fickian diffusion was best fitted and interpreted by the Higuchi equation. The results indicate ADBS is an ideal hydrophilic excipient which extends the in vitro release of water-soluble drugs for 24 h.
['Liu|Guodong|G|', 'Hong|Yan|Y|', 'Gu|Zhengbiao|Z|']
D018360:Crystallography, X-Ray D003692:Delayed-Action Preparations D004337:Drug Carriers D006026:Glycoside Hydrolases D006863:Hydrogen-Ion Concentration D007700:Kinetics D009994:Osmolar Concentration D010194:Pancreatin D012212:Rheology D012995:Solubility D013213:Starch D013607:Tablets
Amorphous debranched starch Tablet Pullulanase Excipient Extended release