The new European guidelines for prevention of cardiovascular disease are misleading.
Introduction: The European Society of Cardiology and European Atherosclerosis Society (ESC/EAS) have recently published three major revisions of their guidelines for the management of chronic heart disease, blood lipids, and diabetes. Areas covered: We have scrutinized these guidelines in detail and found that the authors have ignored many studies that are in conflict with their conclusions and recommendations. Expert commentary: The authors of the guidelines have ignored that LDL-cholesterol (LDL-C) of patients with acute myocardial infarction is lower than normal; that high cholesterol is not a risk factor for diabetics; that the degree of coronary artery calcification is not associated with LDL-C; and that 27 follow-up studies have shown that people with high total cholesterol or LDL-C live just as long or longer than people with low cholesterol. They have also ignored the lack of exposure-response in the statin trials; that several of these trials have been unable to lower CVD or total mortality; that no statin trial has succeeded with lowering mortality in women, elderly people, or diabetics; and that cholesterol-lowering with statins has been associated with many serious side effects.
['Ravnskov|Uffe|U|', 'Alabdulgader|Abdullah|A|', 'de Lorgeril|Michel|M|', 'Diamond|David M|DM|', 'Hama|Rokuro|R|', 'Hamazaki|Tomohito|T|', 'Hammarskjöld|Björn|B|', 'Harcombe|Zoe|Z|', 'Kendrick|Malcolm|M|', 'Langsjoen|Peter|P|', 'McCully|Kilmer S|KS|', 'Okuyama|Harumi|H|https://orcid.org/0000-0003-3332-4565', 'Sultan|Sherif|S|', 'Sundberg|Ralf|R|']
D000924:Anticholesteremic Agents D002318:Cardiovascular Diseases D002784:Cholesterol D008078:Cholesterol, LDL D005060:Europe D006801:Humans D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors D006937:Hypercholesterolemia D009203:Myocardial Infarction D017410:Practice Guidelines as Topic D012307:Risk Factors
guidelines cardiovascular diabetes Cholesterol statin