Long-Term Results of Intensity-Modulated Radiotherapy for T4 Nasopharyngeal Carcinoma: New Insight into the Value of Concurrent Chemotherapy.
The aim of the study was to report long-term results of intensity-modulated radiotherapy for patients with T4 classification nasopharyngeal carcinoma (NPC). From September 2007 to January 2013, 155 patients were retrospectively analyzed. The estimated 10-year local recurrent-free survival (LRFS), regional recurrent-free survival (RRFS), distant metastasis-free survival (DMFS), and overall survival (OS) rates were 79.4%, 93.2%, 69.0%, and 54.2%, respectively. Cycle number of chemotherapy was a significant predictor of LRFS, OS, and progression-free survival. There was no significant difference in survival rates between patients treated with induction chemotherapy (IC) plus concurrent chemoradiotherapy (CCRT) and patients with IC plus IMRT and adjuvant chemotherapy (AC).
['Kong|Fangfang|F|', 'Zhai|Ruiping|R|', 'Huang|Juan|J|', 'Ying|Hongmei|H|', 'Hu|Chaosu|C|']
D000293:Adolescent D000328:Adult D000368:Aged D059248:Chemoradiotherapy D002648:Child D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D000077274:Nasopharyngeal Carcinoma D050397:Radiotherapy, Intensity-Modulated D055815:Young Adult
Intensity-modulated radiotherapy T4 nasopharyngeal carcinoma concurrent chemotherapy failure pattern neoadjuvant chemotherapy