Adipose Tissue and Modulation of Hypertension.
PURPOSE OF REVIEW
Obesity is a major risk factor for the development of hypertension (HTN), a leading cause of cardiovascular morbidity and mortality. Growing body of research suggests that adipose tissue function is directly associated with the pathogenesis of obesity-related HTN. In this review, we will discuss recent research on the role of adipose tissue in blood pressure (BP) regulation and activation of brown adipose tissue (BAT) as a potentially new therapeutic means for obesity-related HTN.


RECENT FINDINGS
Adipose tissue provides mechanical protection of the blood vessels and plays a role in regulation of vascular tone. Exercise and fasting activate BAT and induce browning of white adipose tissue (WAT). BAT-secreted FGF21 lowers BP and protects against HTN. Browning of perivascular WAT improves HTN. New insights on WAT browning and BAT activation can open new avenues of potential therapeutic interventions to treat obesity-related HTN.
['Das|Eashita|E|', 'Moon|Joon Ho|JH|', 'Lee|Ju Hee|JH|', 'Thakkar|Nikita|N|', 'Pausova|Zdenka|Z|', 'Sung|Hoon-Ki|HK|']
D052437:Adipocytes, Brown D052438:Adipocytes, White D002001:Adipose Tissue, Brown D052436:Adipose Tissue, White D000818:Animals D004734:Energy Metabolism D015444:Exercise D005215:Fasting D005346:Fibroblast Growth Factors D006801:Humans D006973:Hypertension D007334:Insulin-Like Growth Factor I D050356:Lipid Metabolism D009765:Obesity D022722:Thermogenesis D013963:Thyroid Hormones D042461:Vascular Endothelial Growth Factor A
Hypertension Obesity Brown adipose tissue Batokine Blood pressure and endothelial cells