Optimising iron chelation therapy with deferasirox for non-transfusion-dependent thalassaemia patients: 1-year results from the THETIS study.
Efficacy and safety of iron chelation therapy with deferasirox in iron-overloaded non-transfusion-dependent thalassaemia (NTDT) patients were established in the THALASSA study. THETIS, an open-label, single-arm, multicentre, Phase IV study, added to this evidence by investigating earlier dose escalation by baseline liver iron concentration (LIC) (week 4: escalation according to baseline LIC; week 24: adjustment according to LIC response, maximum 30mg/kg/day). The primary efficacy endpoint was absolute change in LIC from baseline to week 52. 134 iron-overloaded non-transfusion-dependent anaemia patients were enrolled and received deferasirox starting at 10mg/kg/day. Mean actual dose±SD over 1year was 14.70±5.48mg/kg/day. At week 52, mean LIC±SD decreased significantly from 15.13±10.72mg Fe/g dw at baseline to 8.46±6.25mg Fe/g dw (absolute change from baseline, -6.68±7.02mg Fe/g dw [95% CI: -7.91, -5.45]; P<0.0001). Most common drug-related adverse events were gastrointestinal: abdominal discomfort, diarrhoea and nausea (n=6 each). There was one death (pneumonia, not considered drug related). With significant and clinically relevant reductions in iron burden alongside a safety profile similar to that in THALASSA, these data support earlier escalation with higher deferasirox doses in iron-overloaded non-transfusion-dependent anaemia patients.
['Taher|Ali T|AT|', 'Cappellini|M Domenica|MD|', 'Aydinok|Yesim|Y|', 'Porter|John B|JB|', 'Karakas|Zeynep|Z|', 'Viprakasit|Vip|V|', 'Siritanaratkul|Noppadol|N|', 'Kattamis|Antonis|A|', 'Wang|Candace|C|', 'Zhu|Zewen|Z|', 'Joaquin|Victor|V|', 'Uwamahoro|Marie José|MJ|', 'Lai|Yong-Rong|YR|']
D000293:Adolescent D000328:Adult D001565:Benzoates D001803:Blood Transfusion D015913:Chelation Therapy D002648:Child D000077588:Deferasirox D003967:Diarrhea D004334:Drug Administration Schedule D054796:Drug Dosage Calculations D005260:Female D005500:Follow-Up Studies D006801:Humans D007501:Iron D007502:Iron Chelating Agents D019190:Iron Overload D008099:Liver D008297:Male D008875:Middle Aged D009325:Nausea D013789:Thalassemia D016896:Treatment Outcome D014230:Triazoles
Iron chelation therapy Non-transfusion-dependent thalassaemia NTDT Dose escalation Iron overload