CUTANEOUS DEMODICOSIS AND UV-INDUCED SKIN NEOPLASIA IN TWO GOELDI'S MONKEYS (CALLIMICO GOELDII).
Two nonrelated Goeldi's monkeys (Callimico goeldii) from the same enclosure developed multifocal alopecia with hyperkeratotic to ulcerative skin lesions on the lower abdomen and inner thighs. Necropsy samples of the first animal showed hyperplastic dermatitis together with in situ carcinoma and intralesional Demodex organisms. The second monkey developed similar lesions 2.5 yr later. Skin scrapings and biopsies also revealed Demodex mites within hyperplastic dermatitis. Long-term treatment with ivermectin, imidacloprid-moxidectin, and sarolaner resolved the demodicosis but skin lesions progressed to actinic keratosis and carcinoma. Both cutaneous neoplasia and demodicosis are rarely described in New World monkeys and these are the first reported cases in Goeldi's monkeys. Since the animals had access to ultraviolet (UV) light, as recommended for indoor-housed callitrichids, the skin tumors were likely UV-induced and the mites have settled particularly within impaired regions. Thus, apparent demodicosis can indicate cutaneous immunosuppression and might alert caretakers to adjust the UV regime.
['Gruber-Dujardin|Eva|E|', 'Ludwig|Carsten|C|', 'Bleyer|Martina|M|', 'Kaup|Franz-Josef|FJ|', 'Mätz-Rensing|Kerstin|K|']
D000818:Animals D000836:Animals, Zoo D000900:Anti-Bacterial Agents D000977:Antiparasitic Agents D001384:Azetidines D016647:Callimico D002294:Carcinoma, Squamous Cell D004338:Drug Combinations D005260:Female D024841:Fluoroquinolones D007306:Insecticides D007559:Ivermectin D018942:Macrolides D008297:Male D008924:Mite Infestations D008992:Monkey Diseases D000073943:Neonicotinoids D009574:Nitro Compounds D012878:Skin Neoplasms D013141:Spiro Compounds D014466:Ultraviolet Rays
carcinoma Demodex mites Actinic keratosis UV radiation challitrichids