Synergistic Interaction in the Analgesic-Like Effects of Maqui Berry and Citrus Is Antagonized by Sweeteners.
Although physiologically pain has a protective function, in many diseases, it is one of the most prominent symptoms. Today, new trends are focused on finding more natural alternatives to conventional treatments to alleviate it. Thereby, the purpose of this investigation was to obtain preclinical data of the antinociceptive properties of a lyophilized obtained from a newly designed maqui-citrus beverage alone and added with different sweeteners. To achieve this objective, maqui berry and citrus pharmacological activity were studied separately, as well as the interaction of both ingredients. In addition, due to the controversy generated regarding the intake of sugars, related to different metabolic diseases, the influence of different sweeteners (stevia, sucralose, or sucrose) was studied to determine their possible influence on the bioactive compounds of this product. For the attainment of our goals, a pharmacological evaluation, using the 1% formalin test, a nociceptive pain model in mice, was performed by using a sub-efficacious dosage of Maqui (25 mg/kg, i.p.) alone and combined with citrus, and then compared with the effects obtained in the presence of the different sweeteners. As a result, the antinociceptive response of the maqui was synergized in the presence of citrus in the neurogenic and inflammatory phases of the formalin test. However, this response was partially or totally reduced in the presence of the sweeteners. Our study gives preclinical evidence that a combination of maqui and citrus might exert beneficial actions to relieve pain, whereas the presence of sweeteners could reduce or avoid it.
['Agulló|Vicente|V|', 'González-Trujano|María Eva|ME|0000-0002-4399-1508', 'Hernandez-Leon|Alberto|A|0000-0002-6864-6735', 'Estrada-Camarena|Erika|E|0000-0001-6634-7494', 'Pellicer|Francisco|F|', 'García-Viguera|Cristina|C|0000-0002-4751-3917']
D000698:Analgesia D000700:Analgesics D000818:Animals D000872:Anthocyanins D001628:Beverages D002957:Citrus D004357:Drug Synergism D045467:Elaeocarpaceae D044950:Flavanones D005638:Fruit D008297:Male D051379:Mice D064209:Phytochemicals D036625:Stevia D013395:Sucrose D013549:Sweetening Agents
citrus sweeteners antinociception anthocyanins polyphenolic compounds