Magnetically triggered nanovehicles for controlled drug release as a colorectal cancer therapy.
Magnetic silica core/shell nanovehicles presenting atherosclerotic plaque-specific peptide-1 (AP-1) as a targeting ligand (MPVA-AP1 nanovehicles) have been prepared through a double-emulsion method and surface modification. Amphiphilic poly(vinyl alcohol) was introduced as a polymer binder to encapsulate various drug molecules (hydrophobic, hydrophilic, polymeric) and magnetic iron oxide (Fe3O4) nanoparticles. Under a high-frequency magnetic field, magnetic carriers (diameter: ca. 50 nm) incorporating the anti-cancer drug doxorubicin collapsed, releasing approximately 80% of the drug payload, due to the heat generated by the rapidly rotating Fe3O4 nanoparticles, thereby realizing rapid and accurate controlled drug release. Simultaneously, the magnetic Fe3O4 themselves could also kill the tumor cells through a hyperthermia effect (inductive heating). Unlike their ungrafted congeners (MPVA nanovehicles), the AP1-grafted nanovehicles bound efficiently to colorectal cancer cells (CT26-IL4Rα), thereby displaying tumor-cell selectivity. The combination of remote control, targeted dosing, drug-loading flexibility, and thermotherapy and chemotherapy suggests that magnetic nanovehicles such as MPVA-AP1 have great potential for application in cancer therapy.
['Kuo|Chih-Yu|CY|', 'Liu|Ting-Yu|TY|', 'Chan|Tzu-Yi|TY|', 'Tsai|Sung-Chen|SC|', 'Hardiansyah|Andri|A|', 'Huang|Li-Ying|LY|', 'Yang|Ming-Chien|MC|', 'Lu|Ruey-Hwa|RH|', 'Jiang|Jeng-Kai|JK|', 'Yang|Chih-Yung|CY|', 'Lin|Chi-Hung|CH|', 'Chiu|Wen-Yen|WY|']
D000818:Animals D000903:Antibiotics, Antineoplastic D000970:Antineoplastic Agents D045744:Cell Line, Tumor D002470:Cell Survival D015179:Colorectal Neoplasms D003692:Delayed-Action Preparations D004317:Doxorubicin D004337:Drug Carriers D065546:Drug Liberation D005290:Ferric Compounds D060526:Magnetic Fields D051379:Mice D046529:Microscopy, Electron, Transmission D008856:Microscopy, Fluorescence D053758:Nanoparticles D013499:Surface Properties D047368:Tumor Burden
Surface modification Magnetic nanovehicles Drug controlled release Stimuli-triggered release Targeting therapy