Test-retest reliability of amygdala response to emotional faces.
In the current study, we evaluated the test-retest reliability of amygdala response using an emotional face-matching task that has been widely used to examine pathophysiology and treatment mechanisms in psychiatric populations. Activation within the fusiform face area (FFA) was also examined. Twenty-seven healthy volunteers completed a variation of the face-matching paradigm developed by Hariri et al. (2000) at two time points approximately 90 days apart. Estimates of test-retest reliability of amygdala response to fearful faces were moderate, whereas angry and happy faces showed poor reliability. Test-retest reliability of the FFA was moderate to strong, regardless of facial affect. Collectively, these findings indicate that the reliability of the BOLD MR signal in the amygdala varies substantially by facial affect. Efforts to improve measurement precision, enlarge sample sizes, or increase the number of assessment occasions seem warranted.
['Sauder|Colin L|CL|', 'Hajcak|Greg|G|', 'Angstadt|Mike|M|', 'Phan|K Luan|KL|']
D000293:Adolescent D000328:Adult D000679:Amygdala D001931:Brain Mapping D004644:Emotions D005149:Facial Expression D005260:Female D059907:Functional Neuroimaging D006801:Humans D007091:Image Processing, Computer-Assisted D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D010364:Pattern Recognition, Visual D011594:Psychometrics D021641:Recognition, Psychology D015203:Reproducibility of Results D055815:Young Adult
Amygdala Emotion Fusiform face area Psychometrics fMRI