Activated factor XI-antithrombin complex presenting as an independent predictor of 30-days mortality in out-of-hospital cardiac arrest patients.
BACKGROUND
Cardiac arrest and cardiopulmonary resuscitation (CPR) are associated with activated coagulation and microvascular fibrin deposition with subsequent multiorgan failure and adverse outcome.


OBJECTIVES
Activated Factor XI-antithrombin (FXIa-AT) complex, activated Factor IX-antithrombin (FIXa-AT) complex and thrombin-antithrombin (TAT) complex were measured as markers of coagulation activation, and evaluated as independent prognostic indicators in out-of-hospital cardiac arrest (OHCA) patients.


METHODS
From February 2007 until December 2010 blood samples were collected in close approximation to CPR from patients with OHCA of assumed cardiac origin. Follow-up samples in survivors were drawn 8-12 h and 24-48 h after hospital admission. All measurements were determined by ELISA.


RESULTS
Thirty-seven patients presented with asystole and 77 with ventricular fibrillation as first recorded heart rhythm. At 30-days follow-up, 70 patients (61.4%) had died. All patients had elevated levels of FXIa-AT complex, FIXa-AT complex and TAT. Initial levels were significantly higher in non-survivors compared to 30-days survivors. A significant increase in risk of 30-days all-cause mortality was observed through increasing quartiles of all three biomarkers in univariate Cox regression analysis. Compared to the lowest quartile (Q1), only FXIa-AT complex levels in Q3 (HR 3.17, p = 0.011) and Q2 (HR 3.02, p = 0.016) were independently associated with all-cause mortality in the multivariable analysis. FIXa-AT complex and TAT-complex did not behave as independent predictors.


CONCLUSIONS
Complexes of FXIa-AT were independently associated with 30-days survival in OHCA-patients.


CLINICAL TRIAL REGISTRATION
ClinicalTrials. gov, NCT02886273.
['Aarsetøy|Reidun|R|', 'Ten Cate|Hugo|H|', 'Spronk|Henri|H|', 'Van Oerle|Rene|R|', 'Aarsetøy|Hildegunn|H|', 'Staines|Harold|H|', 'Nilsen|Dennis W T|DWT|']
D000991:Antithrombins D016887:Cardiopulmonary Resuscitation D015945:Factor XIa D006801:Humans D058687:Out-of-Hospital Cardiac Arrest D011379:Prognosis
Out-of-hospital cardiac arrest Coagulation activation Factor IXa-antithrombin complex Factor XIa-antithrombin complex Prognosis Thrombin-antithrombin complex