Isolated cerebral mucormycosis caused by Rhizomucor pusillus.
A 61-year-old man with relapsing chronic lymphocytic leukaemia, status post allogeneic stem cell transplant and multiple chemotherapy regimens presented to the emergency room after suffering a grand mal seizure. His evaluation revealed a 1.5-2 cm ring-enhancing left temporal lobe brain lesion on the CT scan. This brain lesion was resected and the histopathology revealed an invasive fungal organism resembling mucormycosis. Amplification and sequencing of the 28S ribosomal RNA gene identified the organism as Rhizomucor pusillus The patient was treated with liposomal amphotericin B 5 mg/kg every 24 hours for 4 weeks, and then was transitioned to oral posaconazole. Serial brain imaging at 1 and 3 months, while on therapy, showed significant improvement.
['Farid|Saira|S|', 'AbuSaleh|Omar|O|', 'Liesman|Rachael|R|', 'Sohail|Muhammad Rizwan|MR|http://orcid.org/0000-0001-6499-5543']
D000666:Amphotericin B D000935:Antifungal Agents D001922:Brain Abscess D003937:Diagnosis, Differential D006801:Humans D016867:Immunocompromised Host D015451:Leukemia, Lymphocytic, Chronic, B-Cell D008297:Male D008875:Middle Aged D009091:Mucormycosis D020103:Rhizomucor D012640:Seizures D033581:Stem Cell Transplantation D013702:Temporal Lobe D014057:Tomography, X-Ray Computed
infection (neurology) infectious diseases