Virgin coconut oil supplementation ameliorates cyclophosphamide-induced systemic toxicity in mice.
Virgin coconut oil (VCO) is an unrefined kernal oil, prepared from Cocos nucifera L., having substantial nutritional and medicinal value. Experimental studies have suggested its antioxidant, anti-inflammatory, immunostimulatory and hypolipidemic effects. The present study assesses its effect on formalin-induced chronic inflammation and cyclophosphamide (CTX)-induced systemic toxicity in murine models. Oral administration of VCO effectively reduced formalin-induced paw oedema in mice with more or less similar efficacy as that of diclofenac. The CTX-induced hike in blood urea, creatinine, thiobarbituric acid reactive substances (TBARS) and liver marker enzymes in mice was marginally decreased by VCO (8 g/kg body weight) ingestion orally. The liver and kidney catalase, superoxide dismutase and glutathione peroxidase activities, together with cellular glutathione and TBARS levels, were found to be improved in these animals. Overall the study reveals the protective efficacy of VCO against secondary toxicity induced by CTX possibly through its antioxidant and anti-inflammatory properties.
['Nair|S S|SS|', 'Manalil|J J|JJ|', 'Ramavarma|S K|SK|', 'Suseela|I M|IM|', 'Thekkepatt|A|A|', 'Raghavamenon|A C|AC|']
D000477:Alkylating Agents D000818:Animals D000894:Anti-Inflammatory Agents, Non-Steroidal D000975:Antioxidants D001806:Blood Urea Nitrogen D000074263:Coconut Oil D003404:Creatinine D003520:Cyclophosphamide D019587:Dietary Supplements D004487:Edema D005557:Formaldehyde D007249:Inflammation D008099:Liver D008297:Male D051379:Mice D008807:Mice, Inbred BALB C D010938:Plant Oils D017392:Thiobarbituric Acid Reactive Substances
VCO Antioxidant enzyme chemotherapy cytoprotection lipid peroxidation