Genotoxicity and subchronic toxicity of Sophorae radix in rats: hepatotoxic and genotoxic potential.
Although Sophorae radix (SR) has been traditionally used as a treatment for various clinical symptoms, a comprehensive investigation of its safety has not yet been carried out. Therefore, we present an evaluation of the toxicity of the SR extract that was performed according to the Organization for Economic Cooperation and Development test guidelines for subchronic toxicity and genotoxicity. In an oral subchronic study for 13 weeks, the repeated treatment of rats with 429 or 1500 mg/kg of the SR extract induced a dose-related change in body weight. In particular, the SR extract was observed to exert a significant increase in liver weight along with an increase in serum alkaline phosphatase and alanine transaminase. A small but statistically significant reductions in red blood cell, hemoglobin, and hematocrit levels in the SR extract-treated rats suggest the possibility that anemia, accompanied by liver injury, was at least partially induced. These findings indicate the no-observed-adverse-effect-level for the SR extract was considered to be 10mg/kg/d. And, the data obtained from the chromosome aberration assay showed that SR extract might be considered to be a weak clastogen although no significant micronucleus induction was observed in vivo. Despite the benefits that SR extract can exhibit, this study indicates that SR extract may possess hepatotoxic and genotoxic potential.
['Che|Jeong-Hwan|JH|', 'Yun|Jun-Won|JW|', 'Kim|Yun-Soon|YS|', 'Kim|Seung-Hyun|SH|', 'You|Ji-Ran|JR|', 'Jang|Ja-June|JJ|', 'Kim|Hee Chan|HC|', 'Kim|Hyeon Hoe|HH|', 'Kang|Byeong-Cheol|BC|']
D000284:Administration, Oral D000740:Anemia D000818:Animals D015415:Biomarkers D001835:Body Weight D056486:Chemical and Drug Induced Liver Injury D002869:Chromosome Aberrations D004305:Dose-Response Relationship, Drug D004435:Eating D005260:Female D008297:Male D048629:Micronuclei, Chromosome-Defective D015162:Micronucleus Tests D009152:Mutagenicity Tests D019055:No-Observed-Adverse-Effect Level D008517:Phytotherapy D010936:Plant Extracts D010946:Plants, Medicinal D011916:Rats, Inbred F344 D018570:Risk Assessment D029909:Sophora D013997:Time Factors D059550:Toxicity Tests, Subchronic
Genotoxicity Subchronic Sophorae radix Hepatotoxicity Liver Anemia