Prognostic value of sex-hormone receptor expression in non-muscle-invasive bladder cancer.
PURPOSE
We investigated sex-hormone receptor expression as predicting factor of recurrence and progression in patients with non-muscle invasive bladder cancer.


MATERIALS AND METHODS
We retrospectively evaluated tumor specimens from patients treated for transitional cell carcinoma of the bladder at our institution between January 2006 and January 2011. Performing immunohistochemistry using a monoclonal androgen receptor antibody and monoclonal estrogen receptor-beta antibody on paraffin-embedded tissue sections, we assessed the relationship of immunohistochemistry results and prognostic factors such as recurrence and progression.


RESULTS
A total of 169 patients with bladder cancer were evaluated in this study. Sixty-threepatients had expressed androgen receptors and 52 patients had estrogen receptor beta. On univariable analysis, androgen receptor expression was significant lower in recurrence rates (p=0.001), and estrogen receptor beta expression was significant higher in progression rates (p=0.004). On multivariable analysis, significant association was found between androgen receptor expression and lower recurrence rates (hazard ratio=0.500; 95% confidence interval, 0.294 to 0.852; p=0.011), but estrogen receptor beta expression was not significantly associated with progression rates.


CONCLUSION
We concluded that the possibility of recurrence was low when the androgen receptor was expressed in the bladder cancer specimen and it could be the predicting factor of the stage, number of tumors, carcinoma in situ lesion and recurrence.
['Nam|Jong Kil|JK|', 'Park|Sung Woo|SW|', 'Lee|Sang Don|SD|', 'Chung|Moon Kee|MK|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D014408:Biomarkers, Tumor D002295:Carcinoma, Transitional Cell D018450:Disease Progression D018572:Disease-Free Survival D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D015999:Multivariate Analysis D009361:Neoplasm Invasiveness D011379:Prognosis D011944:Receptors, Androgen D011960:Receptors, Estrogen D012189:Retrospective Studies D012307:Risk Factors D001749:Urinary Bladder Neoplasms D055815:Young Adult
Androgen receptor estrogen receptor beta urinary bladder neoplasms