A comparative study of isolated and metachronous oesophageal squamous cell carcinoma with antecedent upper aerodigestive tract cancer.
OBJECTIVES
Metachronous oesophageal squamous cell carcinoma (OSCC) has been increasing in long-term survivors of upper aerodigestive tract (UADT) cancers in recent years, but the treatment of such cases is not well established. The aim of this study was to compare the prognosis between patients with metachronous OSCC who had antecedent UADT cancers and patients with isolated OSCC.


METHODS
From January 1995 to December 2009, we retrospectively compared the data from 84 patients with metachronous OSCC who had antecedent UADT cancers (metachronous group) with the data from 527 patients with isolated OSCC (isolated group) according to their treatment modalities at Kaohsiung Chang Gung Memorial Hospital.


RESULTS
Overall, the metachronous group had significantly (P = 0.03) worse overall survival than the isolated group. For patients receiving surgery or preoperative chemoradiotherapy followed by surgery, the overall survival rates and incidence of postoperative complications were not significantly different. For patients receiving definite chemoradiotherapy or radiotherapy alone, the metachronous group had significantly (P = 0.02) inferior overall survival compared with the isolated group.


CONCLUSIONS
Offering a radical approach for the treatment of patients with metachronous OSCC who had antecedent UADT cancers is justifiable, with survival rates similar to those of patients with isolated OSCC.
['Lu|Hung-I|HI|', 'Li|Shau-Hsuan|SH|', 'Huang|Wan-Ting|WT|', 'Rau|Kun-Ming|KM|', 'Fang|Fu-Min|FM|', 'Wang|Yu-Ming|YM|', 'Lin|Wei-Che|WC|', 'Tien|Wan-Yu|WY|']
D000368:Aged D002294:Carcinoma, Squamous Cell D004938:Esophageal Neoplasms D000077277:Esophageal Squamous Cell Carcinoma D016629:Esophagectomy D005260:Female D006258:Head and Neck Neoplasms D006801:Humans D053208:Kaplan-Meier Estimate D008297:Male D008875:Middle Aged D016609:Neoplasms, Second Primary D012189:Retrospective Studies D013624:Taiwan
Oesophageal squamous cell carcinoma Upper aerodigestive tract cancer Radiotherapy Metachronous cancer Oesophagectomy