Printing T3 and T4 oral drug combinations as a novel strategy for hypothyroidism.
Hypothyroidism is a chronic and debilitating disease that is estimated to affect 3% of the general population. Clinical experience has highlighted the synergistic value of combining triiodothyronine (T3) and thyroxine (T4) for persistent or recurrent symptoms. However, thus far a platform that enables the simultaneous and independent dosing of more than one drug for oral administration has not been developed. Thermal inkjet (TIJ) 2D printing is a potential solution to enable the dual deposition of T3 and T4 onto orodispersible films (ODFs) for therapy personalisation. In this study, a two-cartridge TIJ printer was modified such that it could print separate solutions of T3 and T4. Dose adjustments were achieved by printing solutions adjacent to each other, enabling therapeutic T3 (15-50 μg) and T4 dosages (60-180 μg) to be successfully printed. Excellent linearity was observed between the theoretical and measured dose for both T3 and T4 (R2 = 0.982 and 0.985, respectively) by changing the length of the print objective (Y-value). Rapid disintegration of the ODFs was achieved (<45 s). As such, this study for the first time demonstrates the ability to produce personalised dose combinations by TIJ printing T3 and T4 onto the same substrate for oral administration.
['Alomari|Mustafa|M|', 'Vuddanda|Parameswara R|PR|', 'Trenfield|Sarah J|SJ|', 'Dodoo|Cornelius C|CC|', 'Velaga|Sitaram|S|', 'Basit|Abdul W|AW|', 'Gaisford|Simon|S|']
D000284:Administration, Oral D004338:Drug Combinations D004339:Drug Compounding D054796:Drug Dosage Calculations D065546:Drug Liberation D004867:Equipment Design D006801:Humans D007037:Hypothyroidism D007700:Kinetics D066330:Printing, Three-Dimensional D012995:Solubility D013678:Technology, Pharmaceutical D013974:Thyroxine D014284:Triiodothyronine
3D printing Ink-jet printing Oral drug delivery systems Personalized medicines Printed pharmaceutical products Two-dimensional printing