Antioxidant gene therapy against neuronal cell death.
Oxidative stress is a common hallmark of neuronal cell death associated with neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, as well as brain stroke/ischemia and traumatic brain injury. Increased accumulation of reactive species of both oxygen (ROS) and nitrogen (RNS) has been implicated in mitochondrial dysfunction, energy impairment, alterations in metal homeostasis and accumulation of aggregated proteins observed in neurodegenerative disorders, which lead to the activation/modulation of cell death mechanisms that include apoptotic, necrotic and autophagic pathways. Thus, the design of novel antioxidant strategies to selectively target oxidative stress and redox imbalance might represent important therapeutic approaches against neurological disorders. This work reviews the evidence demonstrating the ability of genetically encoded antioxidant systems to selectively counteract neuronal cell loss in neurodegenerative diseases and ischemic brain damage. Because gene therapy approaches to treat inherited and acquired disorders offer many unique advantages over conventional therapeutic approaches, we discussed basic research/clinical evidence and the potential of virus-mediated gene delivery techniques for antioxidant gene therapy.
['Navarro-Yepes|Juliana|J|', 'Zavala-Flores|Laura|L|', 'Anandhan|Annadurai|A|', 'Wang|Fang|F|', 'Skotak|Maciej|M|', 'Chandra|Namas|N|', 'Li|Ming|M|', 'Pappa|Aglaia|A|', 'Martinez-Fong|Daniel|D|', 'Del Razo|Luz Maria|LM|', 'Quintanilla-Vega|Betzabet|B|', 'Franco|Rodrigo|R|']
D000818:Animals D000975:Antioxidants D016923:Cell Death D018014:Gene Transfer Techniques D015316:Genetic Therapy D005822:Genetic Vectors D006801:Humans D009410:Nerve Degeneration D009416:Nerve Regeneration D019636:Neurodegenerative Diseases D009474:Neurons D018384:Oxidative Stress D014780:Viruses
Antioxidant gene therapy Oxidative stress Neurodegenerative disorders ROS Virus-mediated gene delivery Brain ischemia