CENPE contributes to pulmonary vascular remodeling in pulmonary hypertension.
Hypoxic pulmonary vascular remodeling is a pathological feature of pulmonary hypertension (PH). Our results showed that centromere-associated protein E (CENPE) expression in PH patients and hypoxia-induced PH rats was significantly higher than that in normal controls. In addition, CENPE deficiency significantly inhibited the development of pulmonary vascular remodeling and right ventricular hypertrophy. Moreover, knocking out CENPE effectively inhibited the proliferation and induced the apoptosis of primary pulmonary artery smooth muscle cells (PASMCs) in vivo. Furthermore, CENPE silencing by small interference significantly inhibited abnormal proliferation, apoptosis resistance, migration, and cell cycle arrest in hypoxia-induced PASMCs. Interestingly, we found that CENPE might exert its biological effect by targeting the transcription of CDK1 proteins.
['Fang|Xiaoyu|X|', 'Xie|Min|M|', 'Liu|Xiansheng|X|', 'He|Yuanzhou|Y|']
D000818:Animals D016203:CDC2 Protein Kinase D002478:Cells, Cultured D002868:Chromosomal Proteins, Non-Histone D004195:Disease Models, Animal D005260:Female D006801:Humans D006976:Hypertension, Pulmonary D017380:Hypertrophy, Right Ventricular D000860:Hypoxia D008297:Male D008875:Middle Aged D032389:Myocytes, Smooth Muscle D011651:Pulmonary Artery D051381:Rats D017207:Rats, Sprague-Dawley D015398:Signal Transduction D066253:Vascular Remodeling
CENPE Pulmonary vascular remodeling Pulmonary hypertension CDK1