Age and Prevalence of Esophageal Reflux Disease in Japanese Patients with Type 2 Diabetes Mellitus: The Dogo Study.
BACKGROUND
Only limited epidemiological evidence exists regarding the relationship between age and gastroesophageal reflux disease (GERD) among Japanese patients with type 2 diabetes mellitus.


AIM
The purpose of the present study is to investigate this issue among Japanese patients with type 2 diabetes mellitus.


METHODS
A multicenter cross-sectional study was conducted in 847 Japanese patients with type 2 diabetes mellitus. Subjects were divided into quartiles according to age: (1) 19 ≤ age < 56, (2) 56 ≤ age < 64, (3) 64 ≤ age < 71, and (4) 71 ≤ age < 89. GERD was defined as present when a subject had a Carlsson-Dent self-administered questionnaire (QUEST) score ≥4.


RESULTS
The prevalence of GERD was 31.5 %. Younger age was independently associated with a higher prevalence of GERD: the adjusted odds ratios (95 % confidence intervals) for GERD in relation to age < 56, 56 ≤ age < 64, 64 ≤ age < 71, and ≥71 were 3.73 (2.16-6.53), 1.98 (1.21-3.27), 1.66 (1.05-2.68), and 1.00 (reference), respectively (P for trend = 0.001). Among 201 patients with PPI or histamine H2-receptor antagonist (H2RA), less than 56 years of age was independently positively associated with GERD: the adjusted OR was 5.68 (95 % CI 1.55-22.18) (P for trend = 0.02).


CONCLUSIONS
Younger age may be independently positively associated with GERD among Japanese type 2 diabetes mellitus patients, regardless of the use of PPI or H2RA.
['Ikeda|Yoshio|Y|', 'Furukawa|Shinya|S|0000-0002-0041-7688', 'Sakai|Takenori|T|', 'Niiya|Tetsuji|T|', 'Miyaoka|Hiroaki|H|', 'Miyake|Teruki|T|', 'Yamamoto|Shin|S|', 'Senba|Hidenori|H|', 'Yamamoto|Yasunori|Y|', 'Arimitsu|Eiji|E|', 'Yagi|Sen|S|', 'Utsunomiya|Hiroki|H|', 'Tanaka|Keiko|K|', 'Takeshita|Eiji|E|', 'Matsuura|Bunzo|B|', 'Miyake|Yoshihiro|Y|', 'Hiasa|Yoichi|Y|']
D000328:Adult D017677:Age Distribution D000368:Aged D000369:Aged, 80 and over D001896:Boron Compounds D015331:Cohort Studies D015897:Comorbidity D003430:Cross-Sectional Studies D003924:Diabetes Mellitus, Type 2 D005260:Female D005764:Gastroesophageal Reflux D006635:Histamine H2 Antagonists D006801:Humans D007564:Japan D008297:Male D008689:Methacrylates D008768:Methylmethacrylates D008875:Middle Aged D016017:Odds Ratio D015995:Prevalence D011446:Prospective Studies D054328:Proton Pump Inhibitors D011795:Surveys and Questionnaires D055815:Young Adult
Age Esophagitis Diabetes Nonerosive reflux disease Young