Cycloisomerization of Olefins in Water.
Preparative reactions that occur efficiently under dilute, buffered, aqueous conditions in the presence of biomolecules find application in ligation, peptide synthesis, and polynucleotide synthesis and sequencing. However, the identification of functional groups or reagents that are mutually reactive with one another, but unreactive with biopolymers and water, is challenging. Shown here are cobalt catalysts that react with alkenes under dilute, aqueous, buffered conditions and promote efficient cycloisomerization and formal Friedel-Crafts reactions. The constraining conditions of bioorthogonal chemistry are beneficial for reaction efficiency as superior conversion at low catalyst concentration is obtained and competent rates in dilute conditions are maintained. Efficiency at high dilution in the presence of buffer and nucleobases suggests that these reaction conditions may find broad application.
['Matos|Jeishla L M|JLM|', 'Green|Samantha A|SA|', 'Chun|Yuge|Y|', 'Dang|Vuong Q|VQ|', 'Dushin|Russell G|RG|', 'Richardson|Paul|P|', 'Chen|Jason S|JS|', 'Piotrowski|David W|DW|', 'Paegel|Brian M|BM|', 'Shenvi|Ryan A|RA|0000-0001-8353-6449']
D000475:Alkenes D002384:Catalysis D003035:Cobalt D056831:Coordination Complexes D003500:Cyclization D006574:Heterocyclic Compounds, 2-Ring D006575:Heterocyclic Compounds, 3-Ring D007536:Isomerism D014867:Water
cobalt DNA isomerization kinetics water chemistry