Novel Concepts of Glioblastoma Therapy Concerning Its Heterogeneity.
Although treatment outcomes of glioblastoma, the most malignant central nervous system (CNS) tumor, has improved in the past decades, it is still incurable, and survival has only slightly improved. Advances in molecular biology and genetics have completely transformed our understanding of glioblastoma. Multiple classifications and different diagnostic methods were made according to novel molecular markers. Discovering tumor heterogeneity only partially explains the ineffectiveness of current anti-proliferative therapies. Dynamic heterogeneity secures resistance to combined oncotherapy. As tumor growth proceeds, new therapy-resistant sub clones emerge. Liquid biopsy is a new and promising diagnostic tool that can step up with the dynamic genetic change. Getting a 'real-time' picture of a specific tumor, anti-invasion and multi-target treatment can be designed. During invasion to the peri-tumoral brain tissue, glioma cells interact with the extracellular matrix components. The expressional levels of these matrix molecules give a characteristic pattern, the invasion spectrum, which possess vast diagnostical, predictive and prognostic information. It is a huge leap forward combating tumor heterogeneity and searching for novel therapies. Using the invasion spectrum of a tumor sample is a novel tool to distinguish between histological subtypes, specifying the tumor grades or different prognostic groups. Moreover, new therapeutic methods and their combinations are under trial. These are crucial steps towards personalized oncotherapy.
['Hutóczki|Gábor|G|0000-0001-7048-0757', 'Virga|József|J|', 'Birkó|Zsuzsanna|Z|0000-0003-2214-6185', 'Klekner|Almos|A|']
D000368:Aged D014408:Biomarkers, Tumor D001921:Brain D001932:Brain Neoplasms D044127:Epigenesis, Genetic D055354:Exosomes D005260:Female D005909:Glioblastoma D005910:Glioma D006801:Humans D007167:Immunotherapy D000073890:Liquid Biopsy D008297:Male D008875:Middle Aged D009696:Nucleic Acids D011379:Prognosis
glioblastoma oncotherapy liquid biopsy invasion spectrum