No effect of yeast-like fungi on lipid metabolism and vascular endothelial growth factor level in children and adolescents with type 1 diabetes mellitus.
BACKGROUND
The objective of the research was to investigate vascular endothelial growth factor (VEGF) levels in the context of lipid metabolism and amount of yeast-like fungi colonizing the digestive tract in children and adolescents with type 1 diabetes mellitus (T1DM).


METHODS
The study included 45 children with T1DM and 27 age- and sex-matched healthy control subjects. In the study sample 33 T1DM patients were administered insulin pump therapy and 12 T1DM patients were administered multiple daily injections with insulin pen devices. All T1DM patients were free of micro- and macrovascular complications. In T1DM patients and healthy controls biochemical tests were performed and measurements of yeast-like fungi colonizing the alimentary tract were conducted. Moreover all study subjects had their serum VEGF levels measured with ELISA test.


RESULTS
The subgroup of children and adolescents with T1DM and yeast-like fungus colony number 10^3 CFU/g was shown statistically significantly lower HbA1c levels, and lower but not statistically significantly total cholesterol, LDL cholesterol and VEGF levels versus T1DM patients with the amount of yeast-like fungi 10^6 CFU/g. Moreover higher HDL levels were observed in this subgroup versus T1DM patients with the amount of yeast-like fungi 10^6 CFU/g although the difference was not statistically significant.


CONCLUSIONS
Our study has shown no influence of yeast-like fungi on lipid metabolism and VEGF level in children and adolescents with T1DM. Comprehensive treatment of T1DM patients and intensive insulin therapy with help of personal insulin pumps can reduce or prevent the development of long-term diabetic complications. Further studies in this field are needed.
['Zorena|Katarzyna|K|', 'Kowalewska|Beata|B|', 'Szmigiero-Kawko|Małgorzata|M|', 'Wąż|Piotr|P|', 'Myśliwiec|Małgorzata|M|']
D000293:Adolescent D016022:Case-Control Studies D002648:Child D003922:Diabetes Mellitus, Type 1 D004797:Enzyme-Linked Immunosorbent Assay D005260:Female D006801:Humans D007004:Hypoglycemic Agents D007260:Infusion Pumps D007328:Insulin D050356:Lipid Metabolism D008297:Male D009181:Mycoses D042461:Vascular Endothelial Growth Factor A
Yeast-like fungi Lipid metabolism Vascular endothelial growth factor Children and adolescents Type 1 diabetes mellitus