Biochemical and biophysical properties of a novel homoisoflavonoid extracted from Scilla persica HAUSSKN.
In this study isolation and structural elucidation of a homoisoflavonoid, 3-(3',4'-dihydroxybenzyl)-8-hydroxy-5,7-dimethoxychroman-4-one (Scillapersicone 1), is reported from Scilla persica HAUSSKN. The structure was solved by a single crystal X-ray analysis. The unit cell parameters are a=11.7676 (2)Å, b=20.1174 (4)Å, c=7.8645 (9)Å, β=93.544 (2)°, V=1858.23 (7)Å(3), monoclinic space group P21/c and four symmetry equivalent molecules in an unit cell. The structure was consistent with the UV, IR, 1D and 2D NMR, HRFAB-MS data. The optimized molecular geometry agrees closely that obtained from the single crystal X-ray crystallography. Furthermore, cytotoxicity of this compound was evaluated by MTT assay on AGS and WEHI-164 cancerous cell lines.
['Hafez Ghoran|Salar|S|', 'Saeidnia|Soodabeh|S|', 'Babaei|Esmaeil|E|', 'Kiuchi|Fumiyuki|F|', 'Dusek|Michal|M|', 'Eigner|Vaclav|V|', 'Dehno Khalaji|Aliakbar|A|', 'Soltani|Alireza|A|', 'Ebrahimi|Pouneh|P|', 'Mighani|Hossein|H|']
D000972:Antineoplastic Agents, Phytogenic D045744:Cell Line, Tumor D002470:Cell Survival D018360:Crystallography, X-Ray D005419:Flavonoids D006801:Humans D008958:Models, Molecular D009369:Neoplasms D010936:Plant Extracts D031445:Scilla
Scilla persica Scillapersicone Cytotoxic activity Liliaceae Single-crystal X-ray Theoretical analysis