Maternal serum concentrations of perfluoroalkyl substances during pregnancy and gestational weight gain: The Avon Longitudinal Study of Parents and Children.
Perfluoroalkyl substances (PFAS) are chemicals used in the manufacture of consumer products. PFAS may act as endocrine disruptors, influencing metabolic pathways and weight-related outcomes. Previous studies observed an association between perfluorooctane sulfonic acid (PFOS) and higher gestational weight gain among under-/normal weight mothers. We analyzed associations of maternal serum pregnancy concentrations of PFAS with gestational weight gain (GWG) using data from 905 women in a subsample of the Avon Longitudinal Study of Parents and Children. Women were routinely weighed in antenatal check-ups; absolute GWG was determined by subtracting the first weight measurement from the last. Linear regression was used to explore associations of maternal PFAS concentrations with absolute GWG, stratified by prepregnancy body mass index. Associations of maternal PFOS, perfluorooctanoic acid (PFOA), and perfluorohexane sulfonic acid (PFHxS) concentrations with absolute GWG were null; 10% higher PFOS was associated with GWG of -0.03 kg (95% CI: -0.11, 0.06) among under-/normal weight mothers. Ten percent higher perfluorononanoic acid (PFNA) was associated with a higher GWG of 0.09 kg (95% CI: 0.02, 0.16) among under-/normal weight mothers. Overall, findings suggest no association between maternal PFOA, PFOS, and PFHxS concentrations and GWG, and a weak positive association between maternal PFNA and GWG.
['Marks|Kristin J|KJ|', 'Jeddy|Zuha|Z|', 'Flanders|W Dana|WD|', 'Northstone|Kate|K|', 'Fraser|Abigail|A|', 'Calafat|Antonia M|AM|', 'Kato|Kayoko|K|', 'Hartman|Terryl J|TJ|']
D000328:Adult D017738:Alkanesulfonic Acids D000079687:Biological Monitoring D002210:Caprylates D004785:Environmental Pollutants D005227:Fatty Acids D005260:Female D005466:Fluorocarbons D000078064:Gestational Weight Gain D006801:Humans D007231:Infant, Newborn D008297:Male D011247:Pregnancy
Perfluoroalkyl substances Gestational weight gain Endocrine disruptors Perfluorooctane sulfonic acid (PFOS) Perfluorooctanoic acid (PFOA) Perfluorohexane sulfonic acid (PFHxS) Perfluorononanoic acid (PFNA) ALSPAC