Secukinumab retreatment associated psoriasis flare with pustules.
This case report describes a patient with plaque psoriasis and psoriatic arthritis who experienced IL-17A blocking antibody secukinumab treatment-interruption followed by re-treatment. The patient showed heterogeneous responses; significant improvement at initial introduction of secukinumab with rapid deterioration after discontinuation, followed by worsening symptoms and pustular eruption with reintroduction, and skin clearance after dose escalation.
['El-Komy|Mohamed|M|http://orcid.org/0000-0002-9653-2938', 'Amer|Marwa|M|', 'Mostafa|Alshimaa|A|', 'ElKalioby|Mona|M|']
secukinumab Plaque psoriasis psoriatic arthritis paradoxical psoriasis