2,3,7,8-tetrachlorodibenzo-p-dioxin and the viral infection.
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a widespread highly toxic environmental contaminant, suppresses immune response and leads to an increased susceptibility to infectious agents. In particular, several studies have provided evidence that TCDD decreases resistance to numerous viruses. Indeed, in vivo and in vitro investigations showed that the presence of TCDD is able to interfere with the replication of both human and animal viruses, such as influenza A viruses, coxsackie virus B3, immunodeficiency virus type-1 (HIV-1), cytomegalovirus (CMV), herpes simplex II, and bovine herpesvirus 1. Moreover, TCDD could induce an exacerbation of latent infection produced by HIV-1, CMV or Epstein-Barr virus. In this review, we first describe the general effects of TCDD exposure on mammalian cells, then we focus on its influence on the viral infections. Overall, the available data support the concept that TCDD exposure may act as an additional risk factor in promoting of viral diseases.
['Fiorito|Filomena|F|', 'Santamaria|Rita|R|', 'Irace|Carlo|C|', 'De Martino|Luisa|L|', 'Iovane|Giuseppe|G|']
D000818:Animals D003384:Coxsackievirus Infections D004770:Enterovirus D004781:Environmental Exposure D006564:Herpesviridae D006566:Herpesviridae Infections D054884:Host-Pathogen Interactions D006801:Humans D009980:Influenza A virus D007251:Influenza, Human D000072317:Polychlorinated Dibenzodioxins D014777:Virus Diseases
TCDD Viruses AhR