Overweight adolescents with type 2 diabetes have significantly higher lipoprotein abnormalities than those with type 1 diabetes.
AIM
Diabetes-associated glucoregulatory derangements may precipitate atherogenesis in childhood and CVD risk, particularly with obesity. We aimed to delineate lipoprotein profile differences between children with type 1 and 2 diabetes who are overweight/obese.


METHODS
Data were obtained from electronic medical records of patients ≥85th BMI percentile with type 1 (n=159) and type 2 (n=77) diabetes, ages 12-19y. Group differences were evaluated by correlations and general linear modeling analysis, adjusting for BMI, HbA1c, and diabetes duration.


RESULTS
There were no group differences in TC, LDL, or non-HDL. Fewer subjects with type 1 diabetes had low HDL (17 vs. 30%; P<0.05). While no difference in HbA1c level was observed between groups, HbA1c was positively correlated with TC (P≤0.0001), LDL (P≤0.0001), non-HDL (P≤0.0001), ApoB100 (P≤0.0001), and LDL pattern B (P≤0.0001). In adjusted models, apoB100 (85.4 vs. 91.3mg/dl; P<0.05) and incidence of LDL pattern B (21 vs. 42%; P<0.01) were lower in subjects with type 1 diabetes. BMI was inversely correlated with HDL, HDL-2 and HDL-3 (all P≤0.0001). The correlation of BMI with HDL-2 and HDL-3 were attenuated when evaluating subjects by diabetes type.


CONCLUSIONS
Despite having no difference in absolute LDL levels, children with type 2 diabetes were more likely to have small, dense LDL particle pattern, higher apo B100 and lower total HDL, HDL-2, and HDL-3 fractions. Furthermore, poor glycemic control was associated with abnormal lipoprotein profiles in patients with both type 1 and 2 diabetes.
['Hanks|Lynae J|LJ|', 'Pelham|James Heath|JH|', 'Vaid|Shalini|S|', 'Casazza|Krista|K|', 'Ashraf|Ambika P|AP|']
D000293:Adolescent D000407:Alabama D002648:Child D003430:Cross-Sectional Studies D003922:Diabetes Mellitus, Type 1 D003924:Diabetes Mellitus, Type 2 D050171:Dyslipidemias D005260:Female D006801:Humans D008074:Lipoproteins D008297:Male D050177:Overweight D015995:Prevalence D012189:Retrospective Studies D055815:Young Adult
Type 2 diabetes Type 1 diabetes Lipoprotein profile Cardiovascular diseases Pediatric obesity