An Astragalus membranaceus based eco-friendly biomimetic synthesis approach of ZnO nanoflowers with an excellent antibacterial, antioxidant and electrochemical sensing effect.
Nowadays featuring outstanding eco-friendliness, the phytochemical fabrication method of nanostructures is very popular. Here, we propose to utilize the Astragalus membranaceus extract as the reducing and capping agent to stabilize the metal and to avoid the aggregations of nanoparticles during ZnO nanoflowers synthesis procedure. As a result, the whole fabrication procedure was highly efficient and cost-effective without requiring a special environment of high pressure or elevated temperature and without chemical hazards used or produced. After the fabrication, detailed characterization about material morphology and crystal structure was carried out, including scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscope (FTIR). Moreover, the ZnO nanoflowers demonstrated distinctive antibacterial, antioxidant and electrochemical sensing effect. Specifically, ZnO nanoflowers had an antibacterial inhibition zone of 19(±0.7) and 15(±0.8) mm in diameter against the concentration of 50 μL (1 mg/mL) Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), which is greatly improved compared to the reference drug (Kanamycin). Besides, antioxidant activity was also tested using H2O2 free radical scavenging assay and 60% 2,2-diphenyl-1-picrylhydrazyl (DPPH) inhibition of 0.5 mg/mL was reported. Finally, controlled by the diffusion process during the charge transfer procedure, 4-nitorphenol was dramatically reduced and a limit of detection of 0.08 μM by ZnO nanoflowers modified electrode was observed during the cyclic voltammetry (CV) experiment. Because the phenolic compounds originating from Astragalus membranaceus helped to facilitate the electron transfer, the limit of detection was lower compared to other materials, such as copper oxide nanoparticles (Cu2O-NPs), silicon dioxide/silver nanoparticles (SiO2/Ag-NPs), zinc oxide nanoparticles (ZnO-NPs), activated carbon (AC) and cobalt oxide nanocubes (Co3O4). Therefore, featuring easy operation, low-cost and eco-friendliness, our proposed ZnO nanoflowers fabrication method will have a great potential in biomedical and electro-catalytic fields.
['Khan|Faheem Ullah|FU|', 'Khan|Zia Ul Haq|ZUH|', 'Ma|Junxian|J|', 'Khan|Arif Ullah|AU|', 'Sohail|Muhammad|M|', 'Chen|Yongmei|Y|', 'Yang|Yatao|Y|', 'Pan|Xiaofang|X|']
D000900:Anti-Bacterial Agents D000975:Antioxidants D027885:Astragalus propinquus D032701:Biomimetics D004926:Escherichia coli D053768:Metal Nanoparticles D008826:Microbial Sensitivity Tests D012822:Silicon Dioxide D012834:Silver D017550:Spectroscopy, Fourier Transform Infrared D013211:Staphylococcus aureus D014961:X-Ray Diffraction D015034:Zinc Oxide
Astragalus membranaceus ZnO nanoflowers Antioxidant activity Cyclic voltammetry Antibacterial activity