Fabrication of chitosan/polyvinylpyrrolidone hydrogel scaffolds containing PLGA microparticles loaded with dexamethasone for biomedical applications.
One of the most effective approaches for treatment of chronic rhinosinusitis is the use of hydrogel scaffolds with the sustained release of a given required drug. With this in mind, first, we synthesized and characterized poly (lactide-co-glycolide) (PLGA) micro and nano particles loaded with dexamethasone (DEX). We observed a 7-day release of DEX from nanoparticles, while the microparticles showed a 22-day release profile. Due to their slower rate of release, the PLGA microparticles loaded with DEX (PLGADEX microparticles) were specifically chosen for this study. As a second step, chitosan/polyvinylpyrrolidone (PVP) based hydrogels were prepared in various weight ratios and the PLGADEX microparticles were optimized in their structure based on variable gelation times. The morphological studies showed PLGADEX microparticles homogenously dispersed in the hydrogels. Moreover, the effect of weight ratio in the presence and absence of optimum percentage of PLGADEX microparticles was studied. The resultant hydrogels demonstrated a range of advantages, including good mechanical strength, porous morphology, amorphous structure, high swelling ratio, controlled biodegradability rate, and antibacterial activity. Additionally, a cytotoxicity analysis confirmed that the hydrogel scaffolds do not have adverse effects on the cells; our release studies in the hydrogel with the highest PVP content also showed 80% release after 30 days. Based on these results we were able to predict and control some of the mechanical properties, including the microstructure of the scaffolds, as well as the drug release, by optimizing the polymers - microparticle concentration, plus their resulting interactions. This optimized hydrogel can become part of a suitable alternative for treatment of allergic rhinitis and chronic sinusitis.
['Saeedi Garakani|Sadaf|S|', 'Davachi|Seyed Mohammad|SM|', 'Bagher|Zohreh|Z|', 'Heraji Esfahani|Anahita|A|', 'Jenabi|Niki|N|', 'Atoufi|Zhaleh|Z|', 'Khanmohammadi|Mehdi|M|', 'Abbaspourrad|Alireza|A|', 'Rashedi|Hamid|H|', 'Jalessi|Maryam|M|']
D035843:Biomedical Research D055598:Chemical Phenomena D048271:Chitosan D003907:Dexamethasone D004337:Drug Carriers D016503:Drug Delivery Systems D065546:Drug Liberation D020100:Hydrogels D006868:Hydrolysis D008863:Microspheres D010316:Particle Size D011100:Polyglycolic Acid D000077182:Polylactic Acid-Polyglycolic Acid Copolymer D016062:Porosity D013057:Spectrum Analysis D023822:Tissue Engineering
Chitosan Polyvinylpyrrolidone PLGA Rhinosinusitis Drug delivery