Secondary cytoreductive surgery in recurrent epithelial ovarian cancer: A prognostic analysis with 103 cases.
BACKGROUND
Due to satisfactory cytoreductive surgery combined with platinum-based chemotherapy in epithelial ovarian cancer has improved greatly, however, the relapse rate also high. In current study, we analyzed prognostic factors related to secondary cytoreductive surgery in patients with recurrent epithelial ovarian cancer.


METHODS
Clinical and follow-up data from 103 patients with recurrent epithelial ovarian cancer who received secondary cytoreductive surgery and were admitted to our hospital between January 2000 and December 2008 were analyzed.


RESULTS
Median survival after recurrence (RS) after the first relapse for the 103 patients was 36 months, and median overall survival (OS) was 60 months. Patients without visible residual tumors after secondary cytoreductive surgery had longer RS and OS compared to those with residual tumors ≥1 cm. The RS and OS of patients without visible residual tumors after secondary cytoreductive surgery were not significantly different compared to those with residual tumors between 0.1 and 1 cm. Patients with disease free interval (DFI) ≥ 12 months at secondary cytoreductive surgery had longer RS and OS compared to those with DFI < 12 months. Patients with one recurrent lesion had longer RS and OS compared to those with more than one lesion.


CONCLUSIONS
Residual tumor at secondary cytoreductive surgery, DFI and number of lesions were independent prognostic factors for secondary cytoreductive surgery in patients with epithelial ovarian cancer. Patients with DFI ≥12 months and a single lesion had better prognosis for achieving satisfactory cytoreduction, especially the absence of visible residual tumors.
['Fan|Xiao-Mei|XM|', 'Zhang|Jun|J|', 'Niu|Shu-Huai|SH|', 'Li|Kui-Xiu|KX|', 'Song|Cang-Zhu|CZ|']
D000328:Adult D000368:Aged D000077216:Carcinoma, Ovarian Epithelial D002908:Chronic Disease D065426:Cytoreduction Surgical Procedures D005260:Female D006801:Humans D008875:Middle Aged D009364:Neoplasm Recurrence, Local D018365:Neoplasm, Residual D009375:Neoplasms, Glandular and Epithelial D010051:Ovarian Neoplasms D011379:Prognosis D012086:Reoperation D012189:Retrospective Studies D016019:Survival Analysis D013997:Time Factors
Secondary cytoreductive surgery Recurrent epithelial ovarian cancer Survival after recurrence