USP7 manipulation by viral proteins.
Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB) that plays critical roles in the regulation of many cellular processes including epigenetics, tumour suppression, oncogenesis, DNA damage response, immunity and viral infection. USP7 was the first DUB associated with viral infection. Since then other DUB:viral protein interactions have been discovered, however, USP7 continues to be the most targeted DUB interacting with many proteins from various viruses. The selective pressures of evolution have allowed viruses to develop mechanisms that subvert host cellular machinery, promoting survival of the viral niche. Numerous viral proteins have been identified to target and usurp the function of USP7 to their advantage. This review explores novel developments in research focusing on the mechanisms underlying the manipulation of USP7 by viruses.
['Bojagora|Anna|A|', 'Saridakis|Vivian|V|']
D000818:Animals D042822:Genomic Instability D006801:Humans D017874:Immediate-Early Proteins D051379:Mice D011485:Protein Binding D025801:Ubiquitin D000076084:Ubiquitin-Specific Peptidase 7 D014764:Viral Proteins D014780:Viruses
USP7 Ubiquitin EBNA1 ICP0 p53 vIRF1