Identification of genetic risk factors of aggressive periodontitis using genomewide association studies in association with those of chronic periodontitis.
To identify the genetic risk factors for aggressive periodontitis (AgP), it is important to understand the progression and pathogenesis of AgP. The purpose of this review was to summarize the genetic risk factors for AgP identified through a case-control genomewide association study (GWAS) and replication study. The initial studies to identify novel AgP risk factors were potentially biased because they relied on previous studies. To overcome this kind of issue, an unbiased GWAS strategy was introduced to identify genetic risk factors for various diseases. Currently, three genes glycosyltransferase 6 domain containing 1 (GLT6D1), defensin α1 and α3 (DEFA1A3), and sialic acid-binding Ig-like lectin 5 (SIGLEC5) that reach the threshold for genomewide significance have been identified as genetic risk factors for AgP through a case-control GWAS.
['Masumoto|Risa|R|', 'Kitagaki|Jirouta|J|http://orcid.org/0000-0002-3613-6677', 'Fujihara|Chiharu|C|', 'Matsumoto|Masahiro|M|', 'Miyauchi|Shizuka|S|', 'Asano|Yoshihiro|Y|', 'Imai|Atsuko|A|', 'Kobayashi|Kaori|K|', 'Nakaya|Akihiro|A|', 'Yamashita|Motozo|M|', 'Yamada|Satoru|S|', 'Kitamura|Masahiro|M|', 'Murakami|Shinya|S|']
D010520:Aggressive Periodontitis D015703:Antigens, CD D015214:Antigens, Differentiation, Myelomonocytic D016022:Case-Control Studies D055113:Chronic Periodontitis D055106:Genome-Wide Association Study D016695:Glycosyltransferases D006801:Humans D037102:Lectins D010456:Peptides, Cyclic D020641:Polymorphism, Single Nucleotide D012307:Risk Factors D023084:alpha-Defensins
genetic risk factor aggressive periodontitis genomewide association study chronic periodontitis genomewide significance threshold single nucleotide polymorphism