Prognostic value of spot testing urine pH as a novel marker in patients with ST-segment elevation myocardial infarction.
Aim: To investigate the relationship between urinary pH (UpH) and clinical outcome in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention. Methods: Data of 2081 patients with ST-segment elevation myocardial infarction were analyzed, including UpH. Patients were divided into UpH <6.0, 6.0≤ UpH <7.0 and UpH ≥7.0 based on UpH level. The primary outcome was in-hospital all-cause mortality and major adverse clinical events. Results: The incidence of in-hospital clinical outcomes was significantly higher in low UpH group. Multivariate analysis found low UpH (<6.0) was an independent predictor of in-hospital all-cause mortality (OR: 2.85) and major adverse clinical events (OR: 2.39). A Kaplan-Meier analysis showed long-term all-cause mortality was also significantly higher in low UpH group. The multivariate cox analysis demonstrated that low UpH was an independent predictor of long-term all-cause mortality (HR: 2.57). Conclusion: Low UpH is a simple, accessible and powerful marker of poor clinical outcomes in such patients.
['Chen|Wei|W|', 'Lian|Xing-Ji|XJ|', 'Huang|Jie-Leng|JL|', 'Wei|Xue-Biao|XB|', 'Duan|Chong-Yang|CY|', 'Guo|Yan-Song|YS|', 'Chen|Ji-Yan|JY|', 'He|Peng-Cheng|PC|', 'Liu|Yuan-Hui|YH|', 'Tan|Ning|N|']
D000368:Aged D015415:Biomarkers D005260:Female D017052:Hospital Mortality D006801:Humans D006863:Hydrogen-Ion Concentration D053208:Kaplan-Meier Estimate D008297:Male D008875:Middle Aged D015999:Multivariate Analysis D062645:Percutaneous Coronary Intervention D011379:Prognosis D016016:Proportional Hazards Models D012307:Risk Factors D000072657:ST Elevation Myocardial Infarction
ST-segment elevation myocardial infarction outcomes percutaneous coronary intervention mortality predictor biomarker low urine pH metabolism prognosis risk