Gender impact on the correlations between Graves' hyperthyroidism and hyperuricemia in Chinese.
OBJECTIVE
An increased level of serum uric acid (SUA) can be observed in patients with hypothyroidism. Nonetheless, data on the relationship between hyperuricemia and hyperthyroidism was still controversial. Thus, we aimed to analyze the association between Graves' hyperthyroidism and hyperuricemia in Chinese men and women.


METHODS
We recruited 103 male and 254 female patients with Graves' hyperthyroidism, as well as the same number of control subjects. Anthropometric measurements and fasting blood tests were collected and analyzed statistically by binary logistic regressions to determine the risk of developing hyperuricemia in hyperthyroidism.


RESULTS
SUA levels in males were significantly higher than that in females in both patients and controls. SUA levels were also significantly increased in hyperthyroid patients compared to in controls in both genders. The incidence of hyperuricemia rose significantly in subjects with hyperthyroidism with a higher prevalence in males than in females. SUA was negatively correlated with age and fasting glucose in male hyperthyroid patients, while it was positively correlated with body height, body weight, free triiodothyronine, and free thyroxine in female patients. Hyperthyroidism was a risk factor for hyperuricemia with an odd ratio of 4.536 for men and 2.730 for women.


CONCLUSIONS
For hyperuricemia, hyperthyroidism was an important risk factor that should not be neglected, especially for men.
['Liu|Xuehui|X|', 'Zhang|Jianping|J|', 'Meng|Zhaowei|Z|', 'Jia|Qiang|Q|', 'Tan|Jian|J|', 'Zhang|Guizhi|G|', 'Li|Xue|X|', 'Liu|Na|N|', 'Hu|Tianpeng|T|', 'Zhou|Pingping|P|', 'Zhang|Qing|Q|', 'Song|Kun|K|', 'Jia|Qiyu|Q|']
D000293:Adolescent D000328:Adult D000368:Aged D044466:Asians D005260:Female D005783:Gender Identity D006111:Graves Disease D006801:Humans D006980:Hyperthyroidism D033461:Hyperuricemia D008297:Male D008875:Middle Aged D012307:Risk Factors D014527:Uric Acid D055815:Young Adult
Gender Hyperthyroidism Hyperuricemia Serum uric acid (SUA) Graves’ disease (GD)