A review of eight cases of cavernous sinus thrombosis secondary to sphenoid sinusitis, including a12-year-old girl at the present department.
Cavernous sinus thrombosis (CST) is a severe disease which can result from infection of any of the tissues drained by the cavernous sinus. We here review eight cases, including a 12-year-old girl, all secondary to sphenoid sinusitis. The clinical manifestations, laboratory data, imaging findings, pathogens, medications, surgical treatment and clinical outcomes were analyzed. All eight patients had headache and five of them fever. All cases were associated with one or more ophthalmic symptoms. In four cases, computed tomography/magnetic resonance imaging showed isolated sphenoid sinusitis. In three cases, streptococci were isolated from blood culture and two cases showed Staphylococcus aureus in blood and sinus cultures. In seven cases, surgery was undertaken. All eight subjects received antibiotics, and 5 were administered intravenous ceftriaxone and metronidazole. Six subjects received anticoagulation therapy and one received corticosteroids. No mortality was recorded. Three cases showed sequelae, including Lemierre syndrome, ophthalmic complaints, and cranial nerve paralysis. In conclusion, the management of CST should include intravenous antibiotic therapy, combined with endonasal sinus surgery.
['Wang|Yun-Hu|YH|', 'Chen|Po-Yen|PY|', 'Ting|Pei-Ju|PJ|', 'Huang|Fang-Liang|FL|']
D000293:Adolescent D000305:Adrenal Cortex Hormones D000328:Adult D000925:Anticoagulants D002426:Cavernous Sinus D020226:Cavernous Sinus Thrombosis D002648:Child D005260:Female D006801:Humans D057831:Lemierre Syndrome D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D015524:Sphenoid Sinusitis D013203:Staphylococcal Infections D013211:Staphylococcus aureus D013290:Streptococcal Infections D014057:Tomography, X-Ray Computed D055815:Young Adult
Cavernous sinus thrombosis Sphenoid sinusitis Antibiotic Endonasal sinus surgery