Acute encephalopathy in an immunocompromised boy with astrovirus-MLB1 infection detected by next generation sequencing.
We report a case of an immunodeficient 4-year-old boy with acute encephalopathy possibly related to human astrovirus-MLB1 infection. The astrovirus-MLB1 genome was identified in his stool, serum, cerebrospinal fluid, urine, and throat swabs by next generation sequencing. We present additional evidence showing human astroviruses are important infectious agents, regardless of their clades, involving the central nervous system in immunocompromised hosts.
['Sato|Masanori|M|', 'Kuroda|Makoto|M|', 'Kasai|Masashi|M|', 'Matsui|Hikoro|H|', 'Fukuyama|Tetsuhiro|T|', 'Katano|Harutaka|H|', 'Tanaka-Taya|Keiko|K|']
D019350:Astroviridae Infections D001927:Brain Diseases D002675:Child, Preschool D059014:High-Throughput Nucleotide Sequencing D006801:Humans D016867:Immunocompromised Host D008297:Male D001257:Mamastrovirus
Encephalopathy Next generation sequencing Immunodeficiency Astrovirus MLB1