The spectrum of histopathologic patterns secondary to the topical application of EMLA® on vulvar epithelium: clinicopathological correlation in three cases.
EMLA(®) (eutectic mixture of local anesthetics, 2.5% each of lidocaine and prilocaine in an oil and water emulsion) is used as a topical anesthetic. We report three cases of EMLA(®) -induced histopathologic changes on the vulvar epithelium. While there are some similar histopathologic features to those reported in extragenital skin, we describe additional findings on vulvar epithelium, which, to our knowledge, have not been reported previously. The patients presented with clinical signs suggestive of lichen sclerosus or erosive lichen planus (LP), but were all confirmed histopathologically as LP. The biopsy was taken after 15 min of EMLA(®) application and intradermal injection of 1% lidocaine. Blistering prior to intradermal lidocaine and the biopsy procedure was observed in two patients. The histopathologic changes observed in the epithelium included pallor of the upper epidermis, mild spongiosis, intraepidermal subcorneal and suprabasal acantholysis, congestion of the papillary dermal capillaries and extravasated erythrocytes. Basophilic granules were present, but rare, while the necrosis with multifocal clefting was more marked than in extragenital skin. It is important to be aware of these changes occurring on genital mucosa; these may occur in the absence of clinical signs and may obscure the primary underlying pathology, thus representing a diagnostic pitfall.
['Lewis|Fiona M|FM|', 'Agarwal|Anju|A|', 'Neill|Sallie M|SM|', 'Calonje|J Eduardo|JE|', 'Stefanato|Catherine M|CM|']
D000051:Acantholysis D000287:Administration, Topical D000368:Aged D000369:Aged, 80 and over D019162:Anesthetics, Combined D001706:Biopsy D004817:Epidermis D004848:Epithelium D005260:Female D005831:Genital Diseases, Female D006801:Humans D008010:Lichen Planus D008012:Lidocaine D000077442:Lidocaine, Prilocaine Drug Combination D008875:Middle Aged D011318:Prilocaine D014844:Vulva D014845:Vulvar Diseases
EMLA® lichen planus vulva