Early peri-implant bone loss as a predictor for peri-implantitis: A 10-year prospective cohort study.
PURPOSE
To evaluate the effect of early bone loss (EBL), on long-term bone stability and future peri-implantitis development.


MATERIALS AND METHODS
Patients referred for implant placement between 2005 and 2009 were consecutively treated and followed for 10 years. After 10 years, patients were invited for a scientific diagnostic visit to evaluate implant survival and bone loss. Bone level changes were compared with baseline. Non-parametric testing was performed in cross-tabs (Pearson Chi-square and Fishers's exact test). Kaplan-Meier-estimated survival curves were plotted for different thresholds for EBL at different timepoints. Generalized linear mixed models with binomial distribution and logit link for peri-implantitis were fitted. An adjusted logistic mixed model was made to evaluate peri-implantitis, in relation with smoking status, history of periodontitis, and EBL > 0.5 mm.


RESULTS
Four hundred and seven patients (mean age of 64.86 years [range 28-92, SD 10.11]), with 1482 implants, responded to the 10-year recall invitation. After an average follow-up time of 10.66 years (range 10-14, SD 0.87), implant survival was 94.74%. Mean crestal bone loss after 10 years was 0.81 mm (SD 1.58, range 0.00-17.00). One hundred and seventy five implants in 76 patients had peri-implantitis (11.8% on implant level, 18.7% on patient level). EBL of 0.5, 1, and 2 mm were significant predictors for peri-implantitis and implant loss after 10 years. Implants with EBL ≥0.5 mm during the first year of function showed a 5.43 times higher odds for future peri-implantitis development. Probability in developing peri-implantitis was 52.06% when smoking, Periodontal history and EBL of >0.5 mm was combined.


CONCLUSION
The present study suggests that EBL is a predictor for long-term peri-implant pathology, with a significant higher risk for peri-implantitis when early bone loss exceeds the thresholds of 0.5 and 1 mm, especially when additional risk factors such as smoking or susceptibility for periodontal disease prior to implant treatment are present. Clinical trial registration number B670201524796.
['Windael|Simon|S|https://orcid.org/0000-0002-9343-4216', 'Collaert|Bruno|B|', 'De Buyser|Stefanie|S|', 'De Bruyn|Hugo|H|', 'Vervaeke|Stijn|S|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D016301:Alveolar Bone Loss D015921:Dental Implants D006801:Humans D008875:Middle Aged D057873:Peri-Implantitis D010518:Periodontitis D011446:Prospective Studies D012307:Risk Factors
bone loss predictor peri-implantitis early bone loss implant long term