Genetics of Nevirapine Metabolic Pathways at Steady State in HIV-Infected Cambodians.
Nevirapine is metabolized by several hepatic cytochrome P450 (CYP) isoforms to generate four primary hydroxylated metabolites: 2-hydroxynevirapine, 3-hydroxynevirapine, 8-hydroxynevirapine, and 12-hydroxynevirapine. The present study characterized associations between genetic polymorphisms and metabolite ratios in HIV-infected Cambodians. We demonstrate associations between CYP2B6 polymorphisms and metabolite ratios for both 3-hydroxynevirapine and 8-hydroxynevirapine, suggesting involvement of CYP2B6 in generating these metabolites.
['Eloy|Philippine|P|', 'Tessier|Adrien|A|', 'Fan-Havard|Patty|P|', 'Chou|Monidarin|M|', 'Verstuyft|Céline|C|', 'Taburet|Anne-Marie|AM|', 'Haas|David W|DW|', 'Bertrand|Julie|J|0000-0002-6568-1041', '|||']
D000328:Adult D019380:Anti-HIV Agents D044466:Asians D002160:Cambodia D065702:Cytochrome P-450 CYP2B6 D005260:Female D015658:HIV Infections D006801:Humans D008297:Male D019829:Nevirapine D020641:Polymorphism, Single Nucleotide
nevirapine metabolism pathways genetic polymorphisms population pharmacokinetics