Zn/Ag micro-galvanic couples formed on titanium and osseointegration effects in the presence of S. aureus.
Titanium implants possessing simultaneous osseointegration and antibacterial ability are desirable. In this work, three types of Zn/Ag micro-galvanic couples are fabricated on titanium by plasma immersion ion implantation to investigate the osseointegration and antibacterial effects as well as the involved mechanisms. The in vitro findings disclose enhanced proliferation, osteogenic differentiation, and gene expressions of the rat bone mesenchymal stem cells (rBMSCs), as well as good antibacterial ability on all three micro-galvanic couples. Excellent antimicrobial ability is also observed in vivo and the micro-CT and histological results reveal notable osseointegration in vivo despite the presence of bacteria. The Zn/Ag micro-galvanic couple formed on Zn/Ag dual-ion co-implanted titanium shows the best osseointegration as well as good antibacterial properties in vivo obtained from a rabbit tibia model. The difference among the three Zn/Ag micro-galvanic couples can be ascribed to the contact between the Ag NPs and Zn film, which affects the corrosion process. Our results indicate that the biological behavior can be controlled by the corrosion process of the Zn/Ag micro-galvanic couples.
['Jin|Guodong|G|', 'Qin|Hui|H|', 'Cao|Huiliang|H|', 'Qiao|Yuqin|Y|', 'Zhao|Yaochao|Y|', 'Peng|Xiaochun|X|', 'Zhang|Xianlong|X|', 'Liu|Xuanyong|X|', 'Chu|Paul K|PK|']
D000818:Animals D000900:Anti-Bacterial Agents D018786:Bone Substitutes D002460:Cell Line D008297:Male D059630:Mesenchymal Stem Cells D016348:Osseointegration D010012:Osteogenesis D019736:Prostheses and Implants D011817:Rabbits D051381:Rats D012834:Silver D013203:Staphylococcal Infections D013211:Staphylococcus aureus D013499:Surface Properties D014025:Titanium D015032:Zinc
Micro-galvanic couple Titanium Osseointegration Antibacterial ability Silver Zinc