Low DUSP4 Expression Is Associated With Aggressive Phenotypes and Poor Prognosis in Gastric Cancer.
BACKGROUND/AIM
Dual-specificity protein phosphatase 4 (DUSP4) negatively regulates MAPK signaling and is involved in various cellular processes. We herein evaluated the relationship between DUSP4 expression and clinicopathological characteristics in a large series of gastric cancer samples.


MATERIALS AND METHODS
DUSP4 expression was examined by immunohistochemistry in 508 gastric cancer samples. Cases were classified according to the TCGA molecular classification and HER2 amplification. Kaplan-Meier plots were used to predict the relationship between mRNA expression of DUSP4 and survival.


RESULTS
Low expression of DUSP4 was significantly correlated with larger tumor size, higher pT category, positive nodal status, higher stage, lymphovascular invasion, perineural invasion, worse overall survival, and worse recurrence-free survival. No correlation was observed between DUSP4 expression and molecular characteristics. Bioinformatics analysis showed that low mRNA expression was associated with a poor prognosis.


CONCLUSION
Low expression of DUSP4 is associated with aggressive phenotypes of gastric cancer and a poor prognosis.
['Bang|Seongsik|S|', 'Jee|Seungyun|S|', 'Kim|Hyunsung|H|', 'Jang|Kiseok|K|', 'Park|Hosub|H|', 'Myung|Jae Kyung|JK|', 'Choi|Dongho|D|', 'Shin|Su-Jin|SJ|', 'Paik|Seung Sam|SS|']
D054637:Dual-Specificity Phosphatases D006801:Humans D007150:Immunohistochemistry D054639:Mitogen-Activated Protein Kinase Phosphatases D010641:Phenotype D011379:Prognosis D013274:Stomach Neoplasms
DUSP4 prognosis Gastric cancer dual-specificity protein phosphatase 4