Restricted access to myeloid cells explained.
The lentiviral accessory protein, Vpx, is known to counteract a restriction factor that is specific to myeloid cells, such as macrophages and dendritic cells. This review summarizes the findings in two seminal studies that identify SAMHD1 as the cellular protein that is responsible for myeloid cell restriction, and establish the existence of other types of restriction in these cells.
['Planelles|Vicente|V|']
D000818:Animals D020274:Autoimmune Diseases of the Nervous System D003713:Dendritic Cells D015658:HIV Infections D015497:HIV-1 D015498:HIV-2 D006801:Humans D008264:Macrophages D020559:Monomeric GTP-Binding Proteins D022423:Myeloid Cells D009421:Nervous System Malformations D000076106:SAM Domain and HD Domain-Containing Protein 1 D015302:Simian Immunodeficiency Virus D054334:Viral Regulatory and Accessory Proteins D014779:Virus Replication
myeloid cell Vpx macrophage dendritic cell SAMHD1 Cullin4 DCAF-1 HIV SIV ubiquitin