Reduced autophagy efficiency induces innate immune activation leading to neurodegeneration.
Macroautophagy/autophagy and innate immunity are central processes in neurodegeneration, but it has been unclear whether they work independently or in combination to assault the neuron. We recently demonstrated that reduced efficiency of autophagy causes hyperactivation of innate immunity, which in turn is necessary and sufficient for loss of dopaminergic neurons in a Cdk5-mediated model of degeneration in Drosophila. Genetically restoring autophagy, or reducing innate immune activation, rescues the dopaminergic neuron loss that occurs due to altered Cdk5 activity. This work revealed an alliance of innate immunity and autophagy that causes neuron loss in Cdk5-mediated neurodegeneration.
['Shukla|Arvind K|AK|', 'Giniger|Edward|E|0000-0002-8340-6158']
D000818:Animals D001343:Autophagy D051360:Cyclin-Dependent Kinase 5 D059290:Dopaminergic Neurons D029721:Drosophila Proteins D007113:Immunity, Innate D009410:Nerve Degeneration
innate immunity neurodegeneration Cdk5 Anti-microbial peptide p35