Population Pharmacokinetic and Pharmacodynamic Analysis To Evaluate a Switch to Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate in People Living with HIV-1.
Doravirine is a non-nucleoside reverse transcriptase inhibitor for treatment of human immunodeficiency virus type 1 (HIV-1) infection. A population pharmacokinetic (PK) model for treatment-naive participants in doravirine clinical studies was updated with data from switch participants in the DRIVE-SHIFT trial and used to estimate individual post hoc PK parameter values and evaluate the efficacy exposure-response relationship. The results support the 100-mg dose for people living with HIV switching to a doravirine-based regimen (This study has been registered at ClinicalTrials.gov under ClinicalTrials registration no. NCT02397096.).
['Vaddady|Pavan|P|', 'Kandala|Bhargava|B|', 'Yee|Ka Lai|KL|']
D019380:Anti-HIV Agents D000068679:Emtricitabine D005650:Fumarates D015658:HIV Infections D015497:HIV-1 D006801:Humans D019259:Lamivudine D011728:Pyridones D000068698:Tenofovir D014230:Triazoles
doravirine non-nucleoside reverse transcriptase inhibitor fixed-dose combination population pharmacokinetic model switch treatment