Clinical Features of Systemic Metastatic Retinal Lymphoma in Japanese Patients.
PURPOSE
Systemic metastatic retinal lymphoma (SMRL) originates in systemic organs. It has been reported to exhibit clinical features similar to those of primary vitreoretinal lymphoma (PVRL). We report six cases of SMRL in a single-center survey in Japan.


METHODS
The clinical and pathologic features in SMRL at the Kyushu University Hospital were retrospectively studied.


RESULTS
The mean patient age at the onset of ocular involvement was 75.3 years. Four patients had brain involvement. The primary sites were: breast (2); chest (1); testis (1); intestinal tract (1); and nasal sinus (1). In all patients, the cytology of vitreous samples indicated diffuse large B-cell lymphoma (DLBCL).


CONCLUSIONS
DLBCL is the most common subtype in our study. The prevalence of CNS involvement in patients with SMRL is similar to that with PVRL. The testis and breast may be common sites of origin for SMRL.
['Taki|Rumiko|R|', 'Takeda|Atsunobu|A|', 'Yoshikawa|Hiroshi|H|', 'Fukuhara|Takako|T|', 'Arita|Ryoichi|R|', 'Suehiro|Yoko|Y|', 'Choi|Ilseung|I|', 'Kumano|Yuji|Y|', 'Nakamura|Takao|T|', 'Ishibashi|Tatsuro|T|']
D000368:Aged D000369:Aged, 80 and over D044466:Asians D001943:Breast Neoplasms D005260:Female D015321:Gene Rearrangement D006801:Humans D007143:Immunoglobulin Heavy Chains D007414:Intestinal Neoplasms D007564:Japan D008207:Lymphatic Metastasis D016403:Lymphoma, Large B-Cell, Diffuse D008297:Male D009363:Neoplasm Proteins D010255:Paranasal Sinus Neoplasms D016133:Polymerase Chain Reaction D019572:Retinal Neoplasms D012189:Retrospective Studies D013736:Testicular Neoplasms D013899:Thoracic Neoplasms D014821:Vitrectomy D014822:Vitreous Body
Clinical features vitreoretinal lymphoma CNS involvement primary organs single-center study