The sympathetic nervous system is controlled by transient receptor potential vanilloid 1 in the regulation of body temperature.
Transient receptor potential vanilloid 1 (TRPV1) is involved in sensory nerve nociceptive signaling. Recently, it has been discovered that TRPV1 receptors also regulate basal body temperature in multiple species from mice to humans. In the present study, we investigated whether TRPV1 modulates basal sympathetic nervous system (SNS) activity. C57BL6/J wild-type (WT) mice and TRPV1 knockout (KO) mice were implanted with radiotelemetry probes for measurement of core body temperature. AMG9810 (50 mg/kg) or vehicle (2% DMSO/5% Tween 80/10 ml/kg saline) was injected intraperitoneally. Adrenoceptor antagonists or vehicle (5 ml/kg saline) was injected subcutaneously. In WT mice, the TRPV1 antagonist, AMG9810, caused significant hyperthermia, associated with increased noradrenaline concentrations in brown adipose tissue. The hyperthermia was significantly attenuated by the β-adrenoceptor antagonist propranolol, the mixed α-/β-adrenoceptor antagonist labetalol, and the α1-adrenoceptor antagonist prazosin. TRPV1 KO mice have a normal basal body temperature, indicative of developmental compensation. d-Amphetamine (potent sympathomimetic) caused hyperthermia in WT mice, which was reduced in TRPV1 KO mice, suggesting a decreased sympathetic drive in KOs. This study provides new evidence that TRPV1 controls thermoregulation upstream of the SNS, providing a potential therapeutic target for sympathetic hyperactivity thermoregulatory disorders.
['Alawi|Khadija M|KM|', 'Aubdool|Aisah A|AA|', 'Liang|Lihuan|L|', 'Wilde|Elena|E|', 'Vepa|Abhinav|A|', 'Psefteli|Maria-Paraskevi|MP|', 'Brain|Susan D|SD|', 'Keeble|Julie E|JE|']
D000178:Acrylamides D058668:Adrenergic alpha-1 Receptor Antagonists D000319:Adrenergic beta-Antagonists D000818:Animals D001831:Body Temperature D001833:Body Temperature Regulation D019086:Bridged Bicyclo Compounds, Heterocyclic D005334:Fever D006801:Humans D007274:Injections, Intraperitoneal D007279:Injections, Subcutaneous D007741:Labetalol D008297:Male D057507:Mice, 129 Strain D008810:Mice, Inbred C57BL D018345:Mice, Knockout D011224:Prazosin D011433:Propranolol D018340:Receptors, Adrenergic, alpha-1 D011943:Receptors, Adrenergic, beta D013564:Sympathetic Nervous System D050916:TRPV Cation Channels D013686:Telemetry
TRPV1 brown adipose tissue thermogenesis