Light- and pH-activated intracellular drug release from polymeric mesoporous silica nanoparticles.
Surface modified mesoporous silica nanoparticles (MSNs) with reduced toxicity were prepared for light and pH dual triggerable drug delivery system. Both 413 nm light and acidic environment can activate the drug release process, improving the pharmacological action. By applying rhodamine B (RhB) as a model drug, the accumulative RhB release is as high as 95% in pH 5.0 and in irradiation of 413 nm light, compared to only 55% in pH 7.4 and in dark. The anti-cancer drug camptothecin (CPT) loaded nanoparticles can kill cancer cells with IC₅₀ value of 0.02 μg mL(-1) in exposure of 413 nm light, which is much lower than free CPT (about 0.1 μg mL(-1)). Multimodal nonlinear optical imaging microscopy (NLOM) was employed to acquire in vitro coherent anti-Stokes Raman (CARS) and two-photon excited fluorescence (TPEF) images of live MCF-7 cells and showed that the nanoparticles can be taken up by breast tumor cell MCF-7 with high efficiency, indicating its great potential for anti-cancer drug delivery system.
['Tian|Ye|Y|', 'Kong|Yi|Y|', 'Li|Xiaojian|X|', 'Wu|Jun|J|', 'Ko|Alex C-T|AC|', 'Xing|Malcolm|M|']
D000970:Antineoplastic Agents D001943:Breast Neoplasms D004354:Drug Screening Assays, Antitumor D005260:Female D006801:Humans D006863:Hydrogen-Ion Concentration D008027:Light D061986:MCF-7 Cells D046529:Microscopy, Electron, Transmission D053758:Nanoparticles D011108:Polymers D012822:Silicon Dioxide
Mesoporous silica nanoparticle Anticancer drug release Light sensitive Live cell multimodal nonlinear optical imaging (CARS and TPEF) pH sensitive