A narrative review of research progress on the relationship between hypoxia-inducible factor-2α and wound angiogenesis.
OBJECTIVE
This article aims to pay attention to the latest research on the expression, activation and function of hypoxia-inducible factor-2α (HIF-2α) under hypoxia and non-hypoxia conditions, and summarizes the current knowledge about the interaction between hypoxia-inducible factor-2 and angiogenesis, hoping to understand its actions in physiology and disease, with the goal of providing a new strategy for the diagnosis and treatment of wounds.


BACKGROUND
Wound healing is a complex and continuous process, involving coagulation, inflammation, angiogenesis, new tissue formation and extracellular matrix remodeling. Of these, angiogenesis is an essential step. One of the main reasons for non-healing or delayed healing of wounds in peripheral vascular diseases and diabetes is the reduced ability to regenerate microvessels through the process of angiogenesis, which has become the focus of new methods for treating chronic wounds. HIF-2α regulates many aspects of angiogenesis, including vascular maturation, cell migration, proliferation and metastasis.


METHODS
Throughout extensive search of PubMed, summarize the medical research on HIF-2α to 2020.


CONCLUSIONS
HIF-2α is necessary for normal embryonic development by stimulating the expression of angiogenic factors, such as vascular endothelial growth factor (VEGF). It is essential for the formation of new blood vessels in physiological and pathophysiological environments. Targeting HIF-2α in wound healing has much clinical significance for tissue repair.
['Xu|Xing-Wang|XW|', 'Zhang|Jie|J|', 'Guo|Zai-Wen|ZW|', 'Song|Ming-Ming|MM|', 'Sun|Ran|R|', 'Jin|Xin-Yuan|XY|', 'Su|Jian-Dong|JD|', 'Sun|Bing-Wei|BW|']
D051792:Basic Helix-Loop-Helix Transcription Factors D015687:Cell Hypoxia D006801:Humans D000860:Hypoxia D009369:Neoplasms D009389:Neovascularization, Pathologic D042461:Vascular Endothelial Growth Factor A
Angiogenesis hypoxia-inducible factor-2α (HIF-2α) wound healing chronic wounds