In Vitro and In Vivo Effects of Flavonoids on Peripheral Neuropathic Pain.
Neuropathic pain is a common symptom and is associated with an impaired quality of life. It is caused by the lesion or disease of the somatosensory system. Neuropathic pain syndromes can be subdivided into two categories: central and peripheral neuropathic pain. The present review highlights the peripheral neuropathic models, including spared nerve injury, spinal nerve ligation, partial sciatic nerve injury, diabetes-induced neuropathy, chemotherapy-induced neuropathy, chronic constriction injury, and related conditions. The drugs which are currently used to attenuate peripheral neuropathy, such as antidepressants, anticonvulsants, baclofen, and clonidine, are associated with adverse side effects. These negative side effects necessitate the investigation of alternative therapeutics for treating neuropathic pain conditions. Flavonoids have been reported to alleviate neuropathic pain in murine models. The present review elucidates that several flavonoids attenuate different peripheral neuropathic pain conditions at behavioral, electrophysiological, biochemical and molecular biological levels in different murine models. Therefore, the flavonoids hold future promise and can be effectively used in treating or mitigating peripheral neuropathic conditions. Thus, future studies should focus on the structure-activity relationships among different categories of flavonoids and develop therapeutic products that enhance their antineuropathic effects.
['Basu|Paramita|P|', 'Basu|Arpita|A|']
D000818:Animals D000970:Antineoplastic Agents D003929:Diabetic Neuropathies D004195:Disease Models, Animal D004198:Disease Susceptibility D005419:Flavonoids D006801:Humans D009437:Neuralgia D059408:Pain Management D010147:Pain Measurement D010525:Peripheral Nerves D013329:Structure-Activity Relationship
flavonoids spared nerve injury spinal nerve ligation partial sciatic nerve injury chronic constriction injury peripheral neuropathy chemotherapy-induced peripheral neuropathy diabetic neuropathy diabetic painful neuropathy oxidative stress