Prognostic factors for patients with cervical cancer treated with concurrent chemoradiotherapy: a retrospective analysis in a Japanese cohort.
OBJECTIVE
Concurrent chemoradiotherapy (CCRT) is the primary treatment for locally advanced cervical cancer. We studied prognostic factors for patients treated with CCRT.


METHODS
We retrospectively reviewed records of 85 consecutive patients with cervical cancer who were treated with CCRT between 2002 and 2011, with external beam radiation therapy, intracavitary brachytherapy, and platinum-based chemotherapy. Survival data were analyzed with Kaplan-Meier methods and Cox proportional hazard models.


RESULTS
Of the 85 patients, 69 patients (81%) had International Federation of Gynecology and Obstetrics (FIGO) stage III/IV disease; 25 patients (29%) had pelvic lymph node enlargement (based on magnetic resonance imaging), and 64 patients (75%) achieved clinical remission following treatment. Median maximum tumor diameter was 5.5 cm. The 3- and 5-year overall survival rates were 60.3% and 55.5%, respectively. Cox regression analysis showed tumor diameter >6 cm (hazard ratio [HR], 2.3; 95% confidence interval [CI], 1.2 to 4.6), pelvic lymph node enlargement (HR, 2.2; 95% CI, 1.1 to 4.5), and distant metastasis (HR, 10.0; 95% CI, 3.7 to 27.0) were significantly and independently related to poor outcomes.


CONCLUSION
New treatment strategies should be considered for locally advanced cervical cancers with tumors >6 cm and radiologically enlarged pelvic lymph nodes.
['Endo|Daisuke|D|', 'Todo|Yukiharu|Y|', 'Okamoto|Kazuhira|K|', 'Minobe|Shinichiro|S|', 'Kato|Hidenori|H|', 'Nishiyama|Noriaki|N|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D001918:Brachytherapy D059248:Chemoradiotherapy D005260:Female D006801:Humans D053208:Kaplan-Meier Estimate D008207:Lymphatic Metastasis D008875:Middle Aged D011379:Prognosis D016016:Proportional Hazards Models D012189:Retrospective Studies D016896:Treatment Outcome D002583:Uterine Cervical Neoplasms
Chemoradiotherapy Brachytherapy Proportional Hazards Models Retrospective Studies Uterine Cervical Neoplasms