Analytical approaches for the determination of phytocannabinoids and endocannabinoids in human matrices.
Over the last two decades, the role played by phytocannabinoids and endocannabinoids in medicine has gained increasing interest in the scientific community. Upon identification of the plant compound Δ(9)-tetrahydrocannabinol (THC) and of the endogenous substance anandamide (AEA), different methodological approaches and innovative techniques have been developed, in order to evaluate the content of these molecules in various human matrices. In this review, we discuss the analytical methods that are currently used for the identification of phytocannabinoids and endocannabinoids, and we summarize the benefits and limitations of these procedures. Moreover, we provide an overview of the main biological matrices that have been analyzed to date for qualitative detection and quantitative determination of these compounds.
['Battista|Natalia|N|', 'Sergi|Manuel|M|', 'Montesano|Camilla|C|', 'Napoletano|Sabino|S|', 'Compagnone|Dario|D|', 'Maccarrone|Mauro|M|']
D000818:Animals D001095:Arachidonic Acids D001923:Brain Chemistry D063386:Cannabinoid Receptor Agonists D002853:Chromatography, Liquid D013759:Dronabinol D063388:Endocannabinoids D006197:Hair D006801:Humans D013058:Mass Spectrometry D008470:Meconium D008892:Milk D053284:Polyunsaturated Alkamides
anandamide liquid chromatography mass spectrometry Δ9-tetrahydrocannabinol