The thalamo-cortical resting state functional connectivity and abstinence-induced craving in young smokers.
Craving is a significant predicator of smoking relapse. Thus, revealing the neural correlates of craving to smoke in young smokers is important to improve the success of quit attempts. The abstinence-induced craving to smoke has not been explored extensively, although previous studies had investigated the neural substrates of cue-induced craving. Especially, the critical roles of thalamus had been revealed in cigarettes smoking. However, the implication of thalamus resting state functional connectivity (RSFC) in abstinence-induced craving remains unclear. In the current study, by employing a within-subject design in 25 young smokers, both the left and right thalamus RSFC patterns differences were investigated between smoking abstinence condition and smoking satiety condition in young smokers. Moreover, a correlation analysis was employed to assess the relationship between these RSFC changes and abstinence-induced changes in subjective craving. We found young smokers in abstinence state showed reduced RSFC between the left thalamus and right dorsal lateral prefrontal cortex (dlPFC) as well as the right anterior cingulate cortex (ACC) compared with smoking satiety state. There were no significant different RSFC of right thalamus detected across the two sessions. Additionally, the left thalamus-right dlPFC RSFC changes were correlated with the changes in craving induced by 12-h abstinence (i.e., abstinence minus satiety). The present findings provides new evidence that abstinence-induced cravings to smoke are associated with abnormal thalamus RSFC and may shed new insights into the neural mechanism of abstinence-induced craving in young smokers.
['Wang|Chaoyan|C|', 'Zhang|Yong|Y|', 'Yan|Chenyu|C|', 'Sun|Mengtian|M|', 'Cheng|Jingliang|J|']
D001931:Brain Mapping D002540:Cerebral Cortex D066249:Craving D006801:Humans D008279:Magnetic Resonance Imaging D008297:Male D009434:Neural Pathways D012146:Rest D000074285:Smokers D012907:Smoking D013375:Substance Withdrawal Syndrome D013788:Thalamus D014029:Tobacco Use Disorder D055815:Young Adult
Resting state functional connectivity Abstinence-induced craving Young smokers Thalamus