MicroRNA-23b is an independent prognostic marker and suppresses ovarian cancer progression by targeting runt-related transcription factor-2.
Our previous study found that runt-related transcription factor-2 (RUNX2) was upregulated in human epithelial ovarian cancer (EOC) tissues and may be involved in tumor progression and prognosis. The aim of this study was to investigate the mechanism by which RUNX2 is aberrantly expressed in EOC. We firstly confirmed that miRNA-23b directly targets RUNX2 in EOC. Then, ectopic expression of miR-23b significantly inhibited ovarian cancer cell proliferation and tumorigenicity by regulating the expression of RUNX2. Furthermore, the down-regulation of miR-23b was significantly correlated with tumor aggressiveness and poor prognosis of patients with EOC. Collectively, miR-23b may function as tumor suppressor through inhibiting the upregulation of RUNX2, and may be a potential prognostic marker for EOC.
['Li|Weiping|W|', 'Liu|Zhongyu|Z|', 'Chen|Li|L|', 'Zhou|Li|L|', 'Yao|Yuanqing|Y|']
D045744:Cell Line, Tumor D002465:Cell Movement D049109:Cell Proliferation D050659:Core Binding Factor Alpha 1 Subunit D018450:Disease Progression D018572:Disease-Free Survival D005260:Female D015972:Gene Expression Regulation, Neoplastic D016147:Genes, Tumor Suppressor D006801:Humans D053208:Kaplan-Meier Estimate D035683:MicroRNAs D008875:Middle Aged D015999:Multivariate Analysis D009375:Neoplasms, Glandular and Epithelial D010051:Ovarian Neoplasms D011379:Prognosis D016016:Proportional Hazards Models D034622:RNA Interference
MicroRNA-23b Runt-related transcription factor-2 Epithelial ovarian cancer Clinicopathological feature Overall survival Progression-free survival