Delivery Systems of Retinoprotective Proteins in the Retina.
Retinoprotective proteins play important roles for retinal tissue integrity. They can directly affect the function and the survival of photoreceptors, and/or indirectly target the retinal pigment epithelium (RPE) and endothelial cells that support these tissues. Retinoprotective proteins are used in basic, translational and in clinical studies to prevent and treat human retinal degenerative disorders. In this review, we provide an overview of proteins that protect the retina and focus on pigment epithelium-derived factor (PEDF), and its effects on photoreceptors, RPE cells, and endothelial cells. We also discuss delivery systems such as pharmacologic and genetic administration of proteins to achieve photoreceptor survival and retinal tissue integrity.
['Rebustini|Ivan T|IT|', 'Bernardo-Colón|Alexandra|A|', 'Nalvarte|Alejandra Isasi|AI|', 'Becerra|S Patricia|SP|0000-0001-8004-4983']
D000818:Animals D042783:Endothelial Cells D005136:Eye Proteins D006801:Humans D009414:Nerve Growth Factors D010786:Photoreceptor Cells D020419:Photoreceptor Cells, Vertebrate D021381:Protein Transport D012160:Retina D012162:Retinal Degeneration D055351:Retinal Neurons D055213:Retinal Pigment Epithelium D015843:Serpins
delivery systems retinoprotective retina photoreceptors pigmented epithelium-derived factor peptide