Survival and prognostic factors of patients with esophageal fistula in advanced esophageal squamous cell carcinoma.
The aim of the present study was to investigate the survival and prognostic factors of patients who were with advanced esophageal squamous cell carcinoma (ESCC) and developed an esophageal fistula. The data from 221 patients with advanced ESCC developed esophageal fistula from January 2008 to December 2017 at the Harbin Medical University Cancer Hospital was retrospectively analyzed. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated by the Cox proportional hazard models. The median survival time after a diagnosis of the esophageal fistula was calculated using the Kaplan-Meier method. We found that the pathogens infected by patients are common bacteria in nosocomial infection. Besides, the incidence rate of esophagomediastinal fistula was the highest (54.2%) in the lower third of the esophagus. Kaplan-Meier analysis revealed a median survival time of 11.00 months and a median post-fistula survival time of 3.63 months in patients who developed esophageal fistula in advanced esophageal cancer. In the univariate analysis, gender, therapies for ESCC before the development of fistula, type of esophageal fistula, treatment of esophageal fistula and hemoglobin (Hb) level were the factors with significant prognostic value. Gender, type of esophageal fistula and Hb level were identified as independent prognostic factors in further multivariate analysis. In summary, our study demonstrated that several factors are significantly related to patients with esophageal fistula and should be concerned about in clinical practice.
['Guan|Xin|X|', 'Liu|Chao|C|', 'Zhou|Tianshuo|T|', 'Ma|Zhigang|Z|', 'Zhang|Chunhui|C|', 'Wang|Bojun|B|', 'Yao|Yang|Y|', 'Fan|Xiaona|X|', 'Li|Zhiwei|Z|', 'Zhang|Yanqiao|Y|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D015415:Biomarkers D002681:China D004937:Esophageal Fistula D004938:Esophageal Neoplasms D000077277:Esophageal Squamous Cell Carcinoma D005260:Female D006454:Hemoglobins D006801:Humans D015994:Incidence D008297:Male D008875:Middle Aged D011379:Prognosis D012189:Retrospective Studies D018570:Risk Assessment D012307:Risk Factors D012737:Sex Factors D013997:Time Factors
survival prognostic factor esophageal fistula ESCC esophagomediastinal fistula esophagorespiratory fistula