Diffuse pulmonary neuroendocrine cell hyperplasia involving the chest wall.
Diffuse pulmonary neuroendocrine cell hyperplasia (DIPNECH) is characterized by a diffuse hypertrophy of neuroendocrine cells along the distal bronchioles. This condition is characterized by obstructive lung physiology and the development of small carcinoid tumors. We present a case of DIPNECH in a patient undergoing surgery for a primary lung adenocarcinoma. Interestingly, the chest wall also demonstrated involvement of DIPNECH indicated by the presence of small carcinoid tumors. The absence of any lung carcinoid tumor greater than 5 mm and the absence of lymph node metastases render the chest wall involvement unlikely to represent metastatic disease.
['Al-Ayoubi|Adnan M|AM|', 'Ralston|Jonathan S|JS|', 'Richardson|S Russ|SR|', 'Denlinger|Chadrick E|CE|']
D000230:Adenocarcinoma D000369:Aged, 80 and over D001707:Biopsy, Needle D002276:Carcinoid Tumor D018278:Carcinoma, Neuroendocrine D005260:Female D005500:Follow-Up Studies D006801:Humans D006965:Hyperplasia D007150:Immunohistochemistry D033162:Incidental Findings D008175:Lung Neoplasms D055099:Neuroendocrine Cells D011013:Pneumonectomy D018570:Risk Assessment D020775:Thoracic Surgery, Video-Assisted D035441:Thoracic Wall D014057:Tomography, X-Ray Computed D016896:Treatment Outcome
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