Pregnancy outcomes among 31 patients with tetralogy of Fallot, a retrospective study.
BACKGROUND
Tetralogy of Fallot (TOF) is a severe type of congenital heart disease (CHD) and it confers substantial risk to mother and fetus for pregnant women. However, the outcome of pregnancy in women with TOF has not been well studied.


METHODS
Women with TOF who have been seen and/or delivered at our tertiary-care hospital between April 2008 and January 2018 were retrospective reviewed.


RESULTS
A total of 31 pregnant women with TOF were identified during ten-year period. Among these patients, cardiac defects remained uncorrected in 12 women and were surgically repaired in 19 women. The frequency of miscarriages, premature birth, and the percentage of neonates of small for gestational age (SGA) were greater in the uncorrected group than the surgically repaired group (16.67% vs 0, 50% vs 5.26, 41.67% vs 10.53% respectively). The neonatal mortality and fetal mortality were not observed in the surgically repaired group, but were observed in the uncorrected group [3.23% (1/31) and 6.45(2/31) respectively]. Furthermore, the obstetric and cardiac complications in the two groups were stratified and analyzed.


CONCLUSIONS
Surgical correction of TOF is associated with improved maternal and perinatal outcome. However, pregnancy in women with uncorrected TOF was still seen and it was observed at a rate of 1.4/10,000 in our medical center during ten year period. The high degree of ventricular dilatation heart, high functional classifications, serious cardiac arrhythmias and pulmonary hypertension appeared to be associated with maternal and neonatal risks.
['Wang|Kana|K|', 'Xin|Junguo|J|', 'Wang|Xiaodong|X|', 'Yu|Haiyan|H|http://orcid.org/0000-0002-1656-4906', 'Liu|Xinghui|X|']
D000328:Adult D005260:Female D006801:Humans D007223:Infant D007226:Infant Mortality D007231:Infant, Newborn D011247:Pregnancy D011248:Pregnancy Complications D011256:Pregnancy Outcome D012189:Retrospective Studies D012307:Risk Factors D013771:Tetralogy of Fallot
Pregnancy outcome Tetralogy of Fallot (TOF) Congenital heart disease Uncorrected Surgical repair