Microglia-mediated synaptic elimination in neuronal development and disease.
It has recently become clear that microglia, the immune cells of the central nervous system, are far more active in the healthy brain than previously thought. Microglia facilitate many stages of brain development by shaping neuronal connectivity via synaptic elimination. Dysfunction of these same processes likely underlies a wide range of neurological and neurodevelopmental disorders.
['Whitelaw|Brendan S|BS|']
D000818:Animals D001927:Brain Diseases D002633:Chemotaxis D006801:Humans D055495:Neurogenesis D009457:Neuroglia D010587:Phagocytosis D013569:Synapses
development microglia ATP C1q CX3CR1 P2Y12 complement synaptic plasticity synaptic pruning