Over-Expressed FEZF1 Predicts a Poor Prognosis in Glioma and Promotes Glioma Cell Malignant Biological Properties by Regulating Akt-ERK Pathway.
FEZ family zinc finger 1 (FEZF1) is an essential transcription factor during olfactory development. In gastrointestinal tumors, FEZF1 plays an oncogenic role through DNA demethylation. However, the role of FEZF1 in the prognosis of human glioma prognosis remains unclear. In this research, we discovered that FEZF1 was significantly increased in glioma tissues in contrast to normal brain tissues (NBTs; P < 0.05). Moreover, the expression of FEZF1 showed a significant correlation with Eastern Cooperative Oncology Group performance status, World Health Organization grade, isocitrate dehydrogenase 1 mutation, over-expression of glial fibrillary acidic protein and 1p19q co-deletion. Furthermore, a high level of FEZF1 in patients with glioma acted as an independent biomarker to predict reduced survival (P = 0.026). In an in vitro experiment, FEZF1 can promote the proliferation, migration, and invasion of glioma cells and inhibit cell apoptosis by activating Akt-ERK pathway. All these findings suggest that FEZF1 acts as a key oncogene and predicts a poor prognosis in glioma.
['Yu|Mingjun|M|', 'Yu|Shijia|S|', 'Xue|Yixue|Y|', 'Yu|Hai|H|', 'Chen|Duo|D|', 'Wei|Xiangtai|X|', 'Liu|Yunhui|Y|http://orcid.org/0000-0003-3851-2231']
D017209:Apoptosis D014408:Biomarkers, Tumor D001932:Brain Neoplasms D045744:Cell Line, Tumor D005260:Female D005910:Glioma D006801:Humans D008297:Male D008875:Middle Aged D019950:Mitogen-Activated Protein Kinase 1 D048052:Mitogen-Activated Protein Kinase 3 D051057:Proto-Oncogene Proteins c-akt D012097:Repressor Proteins D015398:Signal Transduction D014157:Transcription Factors D015854:Up-Regulation
FEZF1 Prognosis Glioma Malignant biological properties Survival analysis