A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis.
BACKGROUND
Recent studies show that enzymatically hydrolysed collagen, the collagen peptide, is absorbed and distributed to joint tissues and has analgesic and anti-inflammatory properties. A double-blind, placebo-controlled, randomised trial with collagen peptides isolated from pork skin (PCP) and bovine bone (BCP) sources was carried out to study the effectiveness of orally supplemented collagen peptide to control the progression of osteoarthritis in patients diagnosed with knee osteoarthritis. Improvement in treatment was assessed with reduction in Western Ontario McMaster Universities (WOMAC), visual analogue scale (VAS) and quality of life (QOL) scores from baseline to 13 weeks (Visit 7). Safety and tolerability were also evaluated.


RESULTS
There was significant reduction from baseline to Visit 7 in the primary end points of WOMAC and VAS scores and in the secondary end point of QOL score in subjects with PCP and BCP groups, while in subjects with placebo group the end point indices remained unaltered. Furthermore, all the score levels of WOMAC, VAS and QOL decreased significantly (P < 0.01) in the study group compared to placebo group in Visit 7.


CONCLUSION
The study demonstrated that collagen peptides are potential therapeutic agents as nutritional supplements for the management of osteoarthritis and maintenance of joint health.
['Kumar|Suresh|S|', 'Sugihara|Fumihito|F|', 'Suzuki|Keiji|K|', 'Inoue|Naoki|N|', 'Venkateswarathirukumara|Sriraam|S|']
D000328:Adult D000368:Aged D000818:Animals D000894:Anti-Inflammatory Agents, Non-Steroidal D001842:Bone and Bones D002417:Cattle D003094:Collagen D003131:Combined Modality Therapy D019587:Dietary Supplements D004311:Double-Blind Method D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D020370:Osteoarthritis, Knee D010352:Patient Dropouts D010446:Peptide Fragments D011788:Quality of Life D012720:Severity of Illness Index D012867:Skin
clinical study collagen peptide osteoarthritis cartilage