Evaluation of mesoporous silica particles as drug carriers in hydrogels.
Mesoporous silica particles have recently been used in the preparation of solid oral as well as dermal pharmaceutical formulations. In this work, the use of mesoporous silica of different particle size, pore size and pore volume as carrier for curcumin in hydrogels for dermal use was investigated. Oil absorption capacity of the silica, in vitro release of curcumin from formulations and chemical stability of curcumin during three months storage were evaluated. It was found that the silica particles did not alter in vitro release of curcumin compared to an emulsion. Furthermore, curcumin was found to exhibit similar or inferior stability in hydrogels containing mesoporous silica opposed to emulsions.
['Lunter|Dominique Jasmin|DJ|']
D000970:Antineoplastic Agents D003474:Curcumin D004337:Drug Carriers D065546:Drug Liberation D004355:Drug Stability D020100:Hydrogels D010316:Particle Size D016062:Porosity D012822:Silicon Dioxide D012995:Solubility
mesoporous silica hydrogel Curcumin in vitro release storage stability topical formulation