Identifying miRNAs, targets and functions.
microRNAs (miRNAs) are small endogenous non-coding RNAs that function as the universal specificity factors in post-transcriptional gene silencing. Discovering miRNAs, identifying their targets and further inferring miRNA functions have been a critical strategy for understanding normal biological processes of miRNAs and their roles in the development of disease. In this review, we focus on computational methods of inferring miRNA functions, including miRNA functional annotation and inferring miRNA regulatory modules, by integrating heterogeneous data sources. We also briefly introduce the research in miRNA discovery and miRNA-target identification with an emphasis on the challenges to computational biology.
['Liu|Bing|B|', 'Li|Jiuyong|J|', 'Cairns|Murray J|MJ|']
D020413:3' Untranslated Regions D000465:Algorithms D000818:Animals D001665:Binding Sites D019295:Computational Biology D030561:Databases, Nucleic Acid D005786:Gene Expression Regulation D006801:Humans D035683:MicroRNAs D008957:Models, Genetic D058977:Molecular Sequence Annotation D034622:RNA Interference
miRNA functional annotation functional miRNA–mRNA regulatory modules