Regioselective Formal [3+2] Cycloadditions of Urea Substrates with Activated and Unactivated Olefins for Intermolecular Olefin Aminooxygenation.
A new class of intermolecular olefin aminooxygenation reaction is described. This reaction utilizes the classic halonium intermediate as a regio- and stereochemical template to accomplish the selective oxyamination of both activated and unactivated alkenes. Notably, urea chemical feedstock can be directly introduced as the N and O source and a simple iodide salt can be utilized as the catalyst. This formal [3+2] cycloaddition process provides a highly modular entry to a range of useful heterocyclic products with excellent selectivity and functional-group tolerance.
['Wu|Fan|F|', 'Alom|Nur-E|NE|', 'Ariyarathna|Jeewani P|JP|', 'Naß|Johannes|J|', 'Li|Wei|W|0000-0001-8524-217X']
cycloaddition aminooxygenation alkenes homogeneous catalysis oxazoline