Karyotyping of diffuse large B-cell lymphomas: loss of 17p is associated with poor patient outcome.
BACKGROUND
Cytogenetic studies of patients with diffuse large B-cell lymphoma (DLBCL) have revealed a large spectrum of chromosomal abnormalities, some of which may be clinically relevant. We wanted to evaluate possible associations between commonly acquired chromosome aberrations and prognosis in a large cohort of patients.


METHODS
All patients with DLBCL treated at our center during 1999-2010 with an abnormal G-banding karyotype determined on cells short-term cultured from diagnostic biopsies were included. Detailed information on staging, treatment, and outcome was available for all patients.


RESULTS
Of the 110 patients available for analysis, there were 48 deaths and 27 relapses after a median follow-up of 4.5 yr. Eleven different chromosomal abnormalities were detected in more than ten percent of patients. Of those, only loss of 17p, including the TP53 tumor suppressor gene, was significantly associated with inferior long-term prognosis. Five year overall and progression-free survival frequencies were 32% and 27% for patients with loss of 17p and 67% and 59% in patients without this abnormality.


CONCLUSION
In a relatively large cohort of patients with DLBCL analyzed by chromosome banding, loss of 17p was the only chromosomal abnormality associated with inferior survival in uni- and multivariate analysis.
['Fiskvik|Idun|I|', 'Aamot|Hege V|HV|', 'Delabie|Jan|J|', 'Smeland|Erlend B|EB|', 'Stokke|Trond|T|', 'Heim|Sverre|S|', 'Holte|Harald|H|']
D000293:Adolescent D000368:Aged D002869:Chromosome Aberrations D002871:Chromosome Banding D002886:Chromosomes, Human, Pair 17 D005260:Female D006801:Humans D007621:Karyotyping D016403:Lymphoma, Large B-Cell, Diffuse D008297:Male D008875:Middle Aged D009367:Neoplasm Staging D011379:Prognosis D011446:Prospective Studies D016019:Survival Analysis D016159:Tumor Suppressor Protein p53
diffuse large B-cell lymphoma 17p TP53 lymphoma karyotyping