Study of the pathogenesis and treatment of diabetes mellitus through animal models.
Most research in diabetes mellitus (DM) has been conducted in animals, and their replacement is currently a chimera. As compared to when they started to be used by modern science in the 17th century, a very high number of animal models of diabetes is now available, and they provide new insights into almost every aspect of diabetes. Approaches combining human, in vitro, and animal studies are probably the best strategy to improve our understanding of the underlying mechanisms of diabetes, and the choice of the best model to achieve such objective is crucial. Traditionally classified based on pathogenesis as spontaneous or induced models, each has its own advantages and disadvantages. The most common animal models of diabetes are described, and in addition to non-obese diabetic mice, biobreeding diabetes-prone (BB-DP) rats, streptozotocin-induced models, or high-fat diet-induced diabetic C57Bl/6J mice, new valuable models, such as dogs and cats with spontaneous diabetes, are described.
['Brito-Casillas|Yeray|Y|', 'Melián|Carlos|C|', 'Wägner|Ana María|AM|']
D000496:Alloxan D000818:Animals D002371:Cat Diseases D002415:Cats D003920:Diabetes Mellitus D003921:Diabetes Mellitus, Experimental D004041:Dietary Fats D004195:Disease Models, Animal D004283:Dog Diseases D004285:Dogs D006801:Humans D008815:Mice, Inbred Strains D008817:Mice, Mutant Strains D010180:Pancreatectomy D011919:Rats, Inbred Strains D011922:Rats, Mutant Strains D012376:Rodent Diseases D013045:Species Specificity D013311:Streptozocin
Diabetes Animal model Dog Cat Gato Modelo animal Perro