The emerging landscape of circular RNA in cardiovascular diseases.
Circular RNAs (circRNAs), a large novel type of endogenous transcripts, have become a new research hotspot in the field of RNA biology. CircRNAs are mainly generated from exons or introns via multiple mechanisms, and the majority of circRNAs are stable and conserved across different species. Recent studies have revealed that circRNAs can function as miRNA sponges, binding partners of proteins, regulators of transcription, or can even be translated into proteins. Growing evidence has demonstrated that circRNAs play important roles in a wide variety of biological processes such as cell proliferation, apoptosis and senescence, and may serve as potential diagnostic biomarkers or therapeutic targets for various cardiovascular diseases. Here, we review the biogenesis, properties and biological function of circRNAs, and summarize their roles in cardiovascular disorders.
['Zhou|Meng-Yuan|MY|', 'Yang|Jin-Ming|JM|', 'Xiong|Xing-Dong|XD|']
D017398:Alternative Splicing D017209:Apoptosis D001665:Binding Sites D015415:Biomarkers D002318:Cardiovascular Diseases D049109:Cell Proliferation D005786:Gene Expression Regulation D006801:Humans D035683:MicroRNAs D032389:Myocytes, Smooth Muscle D011485:Protein Binding D014176:Protein Biosynthesis D000079962:RNA, Circular
Cardiovascular disease CircRNA MiRNA sponge Biomarker RNA binding protein