miR-208a-3p suppresses cell apoptosis by targeting PDCD4 in gastric cancer.
Programmed cell death 4 (PDCD4) is a novel tumor suppressor gene and a promising target for anticancer therapies. PDCD4 is frequently downregulated in various human cancers; however, the molecular mechanism accounting for the loss expression of PDCD4 in cancers is not fully understood. In this study, we identified specific targeting sites for miR-208a-3p in the 3'-untranslated region (3'-UTR) of the PDCD4 gene which regulated PDCD4 expression. We demonstrated that miR-208a-3p suppressed apoptosis in gastric cancer cells by targeting PDCD4. We also showed that miR-208a-3p promoted the development of tumor growth in xenograft mice by negatively regulating PDCD4. Taken together, this study revealed a critical role for miR-208a-3p as an oncogenic miRNA in gastric carcinogenesis and it may provide a potential novel target for gastric cancer diagnosis and therapy.
['Yin|Kai|K|', 'Liu|Minghui|M|', 'Zhang|Mei|M|', 'Wang|Feng|F|', 'Fen|Min|M|', 'Liu|Zhijian|Z|', 'Yuan|Yutao|Y|', 'Gao|Shanting|S|', 'Yang|Liuqing|L|', 'Zhang|Weijie|W|', 'Zhang|Jianguo|J|', 'Guo|Baoliang|B|', 'Xu|Jianwei|J|', 'Liang|Hongwei|H|', 'Chen|Xi|X|', 'Guan|Wenxian|W|']
D000818:Animals D017209:Apoptosis D051017:Apoptosis Regulatory Proteins D045744:Cell Line, Tumor D015972:Gene Expression Regulation, Neoplastic D064593:Heterografts D006801:Humans D051379:Mice D016513:Mice, SCID D035683:MicroRNAs D016601:RNA-Binding Proteins D013274:Stomach Neoplasms
miR-208a-3p apoptosis PDCD4 gastric cancer microRNA