CRC-113 gene expression signature for predicting prognosis in patients with colorectal cancer.
Colorectal cancer (CRC) is the third leading cause of global cancer mortality. Recent studies have proposed several gene signatures to predict CRC prognosis, but none of those have proven reliable for predicting prognosis in clinical practice yet due to poor reproducibility and molecular heterogeneity. Here, we have established a prognostic signature of 113 probe sets (CRC-113) that include potential biomarkers and reflect the biological and clinical characteristics. Robustness and accuracy were significantly validated in external data sets from 19 centers in five countries. In multivariate analysis, CRC-113 gene signature showed a stronger prognostic value for survival and disease recurrence in CRC patients than current clinicopathological risk factors and molecular alterations. We also demonstrated that the CRC-113 gene signature reflected both genetic and epigenetic molecular heterogeneity in CRC patients. Furthermore, incorporation of the CRC-113 gene signature into a clinical context and molecular markers further refined the selection of the CRC patients who might benefit from postoperative chemotherapy. Conclusively, CRC-113 gene signature provides new possibilities for improving prognostic models and personalized therapeutic strategies.
['Nguyen|Minh Nam|MN|', 'Choi|Tae Gyu|TG|', 'Nguyen|Dinh Truong|DT|', 'Kim|Jin-Hwan|JH|', 'Jo|Yong Hwa|YH|', 'Shahid|Muhammad|M|', 'Akter|Salima|S|', 'Aryal|Saurav Nath|SN|', 'Yoo|Ji Youn|JY|', 'Ahn|Yong-Joo|YJ|', 'Cho|Kyoung Min|KM|', 'Lee|Ju-Seog|JS|', 'Choe|Wonchae|W|', 'Kang|Insug|I|', 'Ha|Joohun|J|', 'Kim|Sung Soo|SS|']
D000368:Aged D000971:Antineoplastic Combined Chemotherapy Protocols D014408:Biomarkers, Tumor D015179:Colorectal Neoplasms D005260:Female D005500:Follow-Up Studies D020869:Gene Expression Profiling D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008297:Male D060787:Neoplasm Grading D009364:Neoplasm Recurrence, Local D009367:Neoplasm Staging D011379:Prognosis D012333:RNA, Messenger D060888:Real-Time Polymerase Chain Reaction D020133:Reverse Transcriptase Polymerase Chain Reaction D015398:Signal Transduction D015996:Survival Rate
colorectal cancer gene expression profile microarray analysis risk prediction