Systolic Dysfunction in Infarcted Mice Does Not Necessarily Lead to Heart Failure: Need to Refine Preclinical Models.
Heart failure (HF) is a major cause of death and hospitalization worldwide. Despite advances in reducing mortality, prognosis remains poor and prevalence has reached epidemic proportions. The limitations of available preclinical models represent a major hurdle in the development of new therapies. Myocardial infarction (MI) is a main cause of HF in humans, and mouse models of MI are often used to study HF mechanisms and experimental treatments. We investigated whether MI in mice constitutes an appropriate model of HF. Permanent ligation of the left coronary artery induced severe and persistent systolic dysfunction and ventricular dilatation. Mouse follow-up for 10 months showed no significant evidence of lung congestion or other pulmonary defects associated with HF. No difference was observed in the capacity of infarcted mice to exercise compared to control animals. These results indicate that severe cardiac dysfunction in mice is not sufficient to demonstrate the presence of HF.
['Villalba-Orero|María|M|', 'López-Olañeta|Marina|M|', 'García-Pavía|Pablo|P|', 'Lara-Pezzi|Enrique|E|']
D000818:Animals D004195:Disease Models, Animal D018450:Disease Progression D006333:Heart Failure D017379:Hypertrophy, Left Ventricular D008297:Male D008810:Mice, Inbred C57BL D009203:Myocardial Infarction D009206:Myocardium D013045:Species Specificity D013318:Stroke Volume D013599:Systole D013997:Time Factors D018487:Ventricular Dysfunction, Left D016277:Ventricular Function, Left D020257:Ventricular Remodeling
Mice Heart failure Preclinical models Myocardial infarction