In Vivo response to compression of 35 breast lesions observed with a two-dimensional locally regularized strain estimation method.
The objective of this study was to assess the in vivo performance of our 2-D locally regularized strain estimation method with 35 breast lesions, mainly cysts, fibroadenomas and carcinomas. The specific 2-D deformation model used, as well as the method's adaptability, led to an algorithm that is able to track tissue motion from radiofrequency ultrasound images acquired in clinical conditions. Particular attention was paid to strain estimation reliability, implying analysis of the mean normalized correlation coefficient maps. For all lesions examined, the results indicated that strain image interpretation, as well as its comparison with B-mode data, should take into account the information provided by the mean normalized correlation coefficient map. Different trends were observed in the tissue response to compression. In particular, carcinomas appeared larger in strain images than in B-mode images, resulting in a mean strain/B-mode lesion area ratio of 2.59 ± 1.36. In comparison, the same ratio was assessed as 1.04 ± 0.26 for fibroadenomas. These results are in agreement with those of previous studies, and confirm the interest of a more thorough consideration of size difference as one parameter discriminating between malignant and benign lesions.
['Brusseau|Elisabeth|E|', 'Detti|Valérie|V|', 'Coulon|Agnès|A|', 'Maissiat|Emmanuèle|E|', 'Boublay|Nawele|N|', 'Berthezène|Yves|Y|', 'Fromageau|Jérémie|J|', 'Bush|Nigel|N|', 'Bamber|Jeffrey|J|']
D000328:Adult D001943:Breast Neoplasms D019245:Compressive Strength D003198:Computer Simulation D055119:Elastic Modulus D054459:Elasticity Imaging Techniques D005260:Female D006244:Hardness D006801:Humans D007090:Image Interpretation, Computer-Assisted D008954:Models, Biological D010173:Palpation D015203:Reproducibility of Results D012680:Sensitivity and Specificity D013314:Stress, Mechanical D013718:Tensile Strength D016217:Ultrasonography, Mammary
Strain estimation Correlation coefficient Breast cancer Ultrasound elastography