Chimeric Humanized Vasculature and Blood: The Intersection of Science and Ethics.
The only curative therapy for diseases such as organ failure is orthotopic organ transplantation. Organ transplantation has been limited due to the shortage of donor organs. The huge disparity between those who need and those who receive transplantation therapy drives the pursuit of alternative treatments. Therefore, novel therapies are warranted. Recent studies support the feasibility of generating human-porcine chimeras that one day would provide humanized vasculature and blood for transplantation and serve as important research models. The ethical issues they raise require open discussion and dialog lest promising lines of inquiry flounder due to unfounded fears or compromised public trust.
['Garry|Daniel J|DJ|', 'Caplan|Arthur L|AL|', 'Garry|Mary G|MG|']
D000818:Animals D001769:Blood D001808:Blood Vessels D002678:Chimera D032984:Ethics, Research D005818:Genetic Engineering D006801:Humans D012586:Science
human ethics chimeras Etv2 complementation pig