Plasma concentrations of amino acid and nicotinamide metabolites in rheumatoid arthritis--potential biomarkers of disease activity and drug treatment.
This study aimed to evaluate changes in plasma amino acid and nicotinamide metabolites concentrations in rheumatoid arthritis (RA) in a search for potential biomarkers of the disease activity and the effect treatment. Analysis of plasma metabolite patterns with liquid chromatography/mass spectrometry revealed specific changes in RA as well as correlations with clinical parameters. Combined concentration parameter calculated as [aspartic acid] + [threonine] + [tryptophan] - [histidine] - [phenylalanine] offered the strongest correlation (p < 0.001) with pain joint count, swollen joint count and DAS 28. Such analysis of amino acid and related metabolite pattern offers potential for diagnosis as well as for monitoring disease progression and therapy in RA.
['Smolenska|Zaneta|Z|', 'Smolenski|Ryszard T|RT|', 'Zdrojewski|Zbigniew|Z|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D000596:Amino Acids D001172:Arthritis, Rheumatoid D015415:Biomarkers D002853:Chromatography, Liquid D005260:Female D006801:Humans D008297:Male D013058:Mass Spectrometry D055432:Metabolomics D008875:Middle Aged D009536:Niacinamide
Amino acids nicotinamide metabolites rheumatoid arthritis metabolomics