ER to Golgi-Dependent Protein Secretion: The Conventional Pathway.
Secretion is the cellular process present in every organism that delivers soluble proteins and cargoes to the extracellular space. In eukaryotes, conventional protein secretion (CPS) is the trafficking route that secretory proteins undertake when are transported from the endoplasmic reticulum (ER) to the Golgi apparatus (GA), and subsequently to the plasma membrane (PM) via secretory vesicles or secretory granules. This book chapter recalls the fundamental steps in cell biology research contributing to the elucidation of CPS; it describes the most prominent examples of conventionally secreted proteins in eukaryotic cells and the molecular mechanisms necessary to regulate each step of this process.
['Viotti|Corrado|C|']
D000818:Animals D022181:COP-Coated Vesicles D020755:Coat Protein Complex I D004721:Endoplasmic Reticulum D006056:Golgi Apparatus D006801:Humans D021381:Protein Transport D011506:Proteins D055571:Secretory Pathway D022142:Secretory Vesicles D020691:rab GTP-Binding Proteins
ER Golgi Plasma membrane Secretory vesicles Secretory granules COPI COPII Regulated secretion Ribosome SNARE SRP TGN Translocon