Picking the Survivor! CRISPR Reveals HIV Dependency Factors.
A new study employs genome-wide loss-of-function CRISPR/Cas9 screening to identify three novel factors for HIV-1 entry. The factors represent promising targets for therapeutics as they are essential for HIV-1 infection, but dispensable for cell survival. The involved pathways were validated in primary CD4+ T cells, target cells for HIV-1.
['Schott|Kerstin|K|', 'König|Renate|R|']
D015496:CD4-Positive T-Lymphocytes D064113:CRISPR-Cas Systems D064112:Clustered Regularly Interspaced Short Palindromic Repeats D015658:HIV Infections D015497:HIV-1 D058605:Host-Derived Cellular Factors D006801:Humans D053586:Virus Internalization D014779:Virus Replication
dependency factors CRISPR/Cas9 screening HIV-1