Genotoxic effects of bisphenol A on somatic cells of female mice, alone and in combination with X-rays.
Bisphenol A (BPA), a monomer used in the manufacture of epoxy, polycarbonate, and polystyrene resins, is a xenoestrogen present in many consumer products. We investigated the effects of 2-week exposure to BPA, either alone or in combination with X-rays, on the induction of DNA damage in somatic cells of female mice in vivo. The micronucleus and alkaline comet assays were used to evaluate genotoxicity. BPA induced DNA strand breaks in lung cells but not in bone marrow lymphocytes, liver, kidney, or spleen cells. Induction of micronuclei was observed only in polychromatic reticulocytes of peripheral blood. Levels of damage following combination exposure to ionizing radiation plus BPA depended on tissue, assay, and time.
['Gajowik|Aneta|A|', 'Radzikowska|Joanna|J|', 'Dobrzyńska|Małgorzata M|MM|']
D000395:Air Pollutants, Occupational D000818:Animals D001559:Benzhydryl Compounds D001854:Bone Marrow Cells D020552:Comet Assay D053960:DNA Breaks D005260:Female D008214:Lymphocytes D051379:Mice D008822:Mice, Transgenic D059351:Organ Sparing Treatments D010636:Phenols D013997:Time Factors D014965:X-Rays
Bisphenol A X-ray Micronucleus Comet assay