Selenium-Rich Yeast Mitigates Aluminum-Mediated Testicular Toxicity by Blocking Oxidative Stress, Inhibiting NO Production, and Disturbing Ionic Homeostasis.
Aluminum (Al) poisoning has been linked to the development of several reproductive system dysfunctions. Dietary supplementation with selenium-rich yeast (SeY) has been shown to prevent a variety of pathologic conditions. In the present study, the potential protect role of SeY on Al-induced testicular toxicity was evaluated, and the possible underlying mechanisms were discussed. Mice were treated with SeY (0.1 mg/kg) and/or Al (10 mg/kg) by oral gavage for 4 weeks. Histopathologic changes were observed in the testes of Al-treated mice. Oxidative stress, ionic disturbances, and the generation of NO systems are believed to have resulted in the observed pathology. Interestingly, SeY supplementation significantly inhibited the Al-induced histopathological and molecular changes and restored these indicators to levels observed in the control animals. These results suggest that SeY exerts a testis-protective effect against Al-induced toxicity through the reduction of oxidative stress, NO production, and the maintenance of ionic homeostasis.
['Cao|Changyu|C|http://orcid.org/0000-0002-1035-852X', 'Zhang|Haoji|H|', 'Wang|Kai|K|', 'Li|Xinran|X|']
D000535:Aluminum D000818:Animals D006706:Homeostasis D008297:Male D051379:Mice D008815:Mice, Inbred Strains D009569:Nitric Oxide D018384:Oxidative Stress D012441:Saccharomyces cerevisiae D012643:Selenium D013737:Testis
Selenium-rich yeast Oxidative stress NO production Ionic homeostasis Aluminum Testis