Structural Basis for CD4+ T Cell Epitope Dominance in Arbo-Flavivirus Envelope Proteins: A Meta-Analysis.
A meta-analysis of CD4+ T cell epitope maps reveals clusters and gaps in envelope-protein (E protein) immunogenicity that can be explained by the likelihood of epitope processing, as determined by E protein three-dimensional structures. Differential processing may be at least partially responsible for variations in disease severity among arbo-flaviruses and points to structural features that modulate protection from disease.
['Landry|Samuel J|SJ|', 'Moss|Daniel L|DL|', 'Cui|Da|D|', 'Ferrie|Ryan P|RP|', 'Fullerton|Mitchell L|ML|', 'Wells|Evan A|EA|', 'Yang|Lu|L|', 'Zhou|Nini|N|', 'Dougherty|Thomas|T|', 'Mettu|Ramgopal R|RR|']
D000818:Animals D015496:CD4-Positive T-Lymphocytes D030562:Databases, Protein D018604:Epitope Mapping D018984:Epitopes, T-Lymphocyte D005416:Flavivirus D000949:Histocompatibility Antigens Class II D006801:Humans D016056:Immunodominant Epitopes D018448:Models, Immunological D011485:Protein Binding D011487:Protein Conformation D013329:Structure-Activity Relationship D014759:Viral Envelope Proteins
antigen processing class II MHC protein helper T cell