Mapping the structural and functional network architecture of the medial temporal lobe using 7T MRI.
Medial temporal lobe (MTL) subregions play integral roles in memory function and are differentially affected in various neurological and psychiatric disorders. The ability to structurally and functionally characterize these subregions may be important to understanding MTL physiology and diagnosing diseases involving the MTL. In this study, we characterized network architecture of the MTL in healthy subjects (n = 31) using both resting state functional MRI and MTL-focused T2-weighted structural MRI at 7 tesla. Ten MTL subregions per hemisphere, including hippocampal subfields and cortical regions of the parahippocampal gyrus, were segmented for each subject using a multi-atlas algorithm. Both structural covariance matrices from correlations of subregion volumes across subjects, and functional connectivity matrices from correlations between subregion BOLD time series were generated. We found a moderate structural and strong functional inter-hemispheric symmetry. Several bilateral hippocampal subregions (CA1, dentate gyrus, and subiculum) emerged as functional network hubs. We also observed that the structural and functional networks naturally separated into two modules closely corresponding to (a) bilateral hippocampal formations, and (b) bilateral extra-hippocampal structures. Finally, we found a significant correlation in structural and functional connectivity (r = 0.25). Our findings represent a comprehensive analysis of network topology of the MTL at the subregion level. We share our data, methods, and findings as a reference for imaging methods and disease-based research.
['Shah|Preya|P|0000-0001-8360-6400', 'Bassett|Danielle S|DS|0000-0002-6183-4493', 'Wisse|Laura E M|LEM|', 'Detre|John A|JA|', 'Stein|Joel M|JM|', 'Yushkevich|Paul A|PA|0000-0001-8543-4016', 'Shinohara|Russell T|RT|', 'Pluta|John B|JB|', 'Valenciano|Elijah|E|', 'Daffner|Molly|M|', 'Wolk|David A|DA|', 'Elliott|Mark A|MA|', 'Litt|Brian|B|', 'Davis|Kathryn A|KA|', 'Das|Sandhitsu R|SR|']
D000328:Adult D001931:Brain Mapping D005260:Female D006801:Humans D008279:Magnetic Resonance Imaging D008297:Male D009434:Neural Pathways D009929:Organ Size D012146:Rest D013702:Temporal Lobe
structural MRI 7 tesla subfields volume connectivity asymmetry hippocampus image segmentation network neuroscience resting-state fMRI