Bilaterality of ovarian endometriomas does not affect the outcome of in vitro fertilization/intracytoplasmic sperm injection in infertile women after laparoscopic cystectomy.
BACKGROUND
To assess whether the unilateral or bilateral lesions can affect ovarian reserve and pregnancy outcome in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in infertility patients underwent laparoscopic cystectomy.


METHODS
A total of 148 IVF/ICSI cycle in patients who had undergone laparoscopic cystectomy for unilateral or bilateral endometriomas were reviewed retrospectively. There were 103 cycles where laparoscopic cystectomy had been carried out for unilateral endometriomas and 45 cycles after bilateral-side surgery. Primary outcome measures were ovarian reserve and ovarian response. Secondary outcome measures were the implantation rate, clinical pregnancy rate, and live birth rate.


RESULTS
The number of dominant follicle on the day of human chorionic gonadotropin (hCG) administration (5.2 ± 3.1 vs. 4.2 ± 2.7; p = 0.048), and oocytes retrieved (10.0 ± 6.9 vs. 7.6 ± 6.6; p = 0.047) were significantly lower in the bilateral-side group compare with the unilateral-side group. However, the mean number of antral follicle count, metaphase II oocytes, the doses of gonadotropin used, fertilization rate, the rate of good quality embryos transferred, implantation rate and clinical pregnancy, live-birth rate and miscarriage rate were similar between the two groups.


CONCLUSION
There were no associations among the bilaterality of ovarian endometriomas, ovarian reserve and pregnancy outcomes in IVF/ICSI cycles. However, bilateral ovarian endometriomas after laparoscopic cystectomy may impair ovarian response as compared to unilateral ovarian endometrioma.
['Yu|Hsing-Tse|HT|', 'Huang|Hong-Yuan|HY|', 'Tseng|Hsiao-Jung|HJ|', 'Wang|Chin-Jung|CJ|', 'Lee|Chyi-Long|CL|', 'Soong|Yung-Kuei|YK|']
D015653:Cystectomy D004715:Endometriosis D005260:Female D006801:Humans D010535:Laparoscopy D065851:Ovarian Reserve D011247:Pregnancy D011256:Pregnancy Outcome D012189:Retrospective Studies D020554:Sperm Injections, Intracytoplasmic
Bilaterality Endometrioma In vitro fertilization Intracytoplasmic sperm injection Laparoscopy