Arginine Methylation: The Coming of Age.
Arginine methylation is a common post-translational modification functioning as an epigenetic regulator of transcription and playing key roles in pre-mRNA splicing, DNA damage signaling, mRNA translation, cell signaling, and cell fate decision. Recently, a wealth of studies using transgenic mouse models and selective PRMT inhibitors helped define physiological roles for protein arginine methyltransferases (PRMTs) linking them to diseases such as cancer and metabolic, neurodegenerative, and muscular disorders. This review describes the recent molecular advances that have been uncovered in normal and diseased mammalian cells.
['Blanc|Roméo S|RS|', 'Richard|Stéphane|S|']
D000818:Animals D001120:Arginine D002454:Cell Differentiation D004249:DNA Damage D004791:Enzyme Inhibitors D006801:Humans D008745:Methylation D008822:Mice, Transgenic D011499:Protein Processing, Post-Translational D011484:Protein-Arginine N-Methyltransferases D015398:Signal Transduction D014158:Transcription, Genetic
arginine methylation post-translational modification epigenetic methyltransferase PRMT1 PRMT5 and S-adenosyl-methionine demethylase methylarginine