A Meta-Analysis Comparing the Efficacy and Safety of Peramivir with Other Neuraminidase Inhibitors for Influenza Treatment.
This meta-analysis compared the efficacy and safety of peramivir compared to other neuraminidase inhibitors (NAIs). Materials and Methods: Data from PubMed, Embase, and Cochrane databases and ClinicalTrials.gov were searched until January 2019. Randomized controlled trials (RCTs) and observational studies (OSs) comparing peramivir with other NAIs for treating influenza were included. The Grading of Recommendations, Assessments, Development, and Evaluations (GRADE) system was used to judge the overall certainty of evidence; the result was moderate. The primary outcome was time to alleviation of symptoms. Twelve articles involving 2681 patients were included in this meta-analysis. We used a random-effect model to pool the effect size, which is expressed as the difference in means (MD), risk ratio (RR), and 95% confidence interval (CI). Results: Overall, peramivir was superior to other NAIs (MD = -11.214 hours, 95% CI: -19.119 to -3.310). The incidence of adverse events (RR = 1.023, 95% CI: 0.717 to 1.460) and serious adverse events (RR = 1.068, 95% CI: 0.702 to 1.625) in the peramivir group was similar to those in the oseltamivir group. In addition, peramivir had higher efficacy than each NAI alone. Conclusion: In conclusion, the efficacy of peramivir might be higher than that of other NAIs, and this agent is tolerated as well as other NAIs.
['Chen|Jui-Yi|JY|', 'Wei|Shih-Kai|SK|', 'Lai|Chih-Cheng|CC|', 'Weng|Teng-Song|TS|', 'Wang|Hsin-Hua|HH|']
D000146:Acids, Carbocyclic D000998:Antiviral Agents D003517:Cyclopentanes D004791:Enzyme Inhibitors D006146:Guanidines D006801:Humans D007251:Influenza, Human D009439:Neuraminidase D064887:Observational Studies as Topic D053139:Oseltamivir D016032:Randomized Controlled Trials as Topic
peramivir neuraminidase inhibitors influenza