Safety Study of Transcranial Static Magnetic Field Stimulation (tSMS) of the Human Cortex.
BACKGROUND
Transcranial static magnetic field stimulation (tSMS) in humans reduces cortical excitability.


OBJECTIVE
The objective of this study was to determine if prolonged tSMS (2 h) could be delivered safely in humans. Safety limits for this technique have not been described.


METHODS
tSMS was applied for 2 h with a cylindric magnet on the occiput of 17 healthy subjects. We assessed tSMS-related safety aspects at tissue level by measuring levels of neuron-specific enolase (NSE, a marker of neuronal damage) and S100 (a marker of glial reactivity and damage). We also included an evaluation of cognitive side effects by using a battery of visuomotor and cognitive tests.


RESULTS
tSMS did not induce any significant increase in NSE or S100. No cognitive alteration was detected.


CONCLUSIONS
Our data indicate that the application of tSMS is safe in healthy human subjects, at least within these parameters.
['Oliviero|A|A|', 'Carrasco-López|M C|MC|', 'Campolo|M|M|', 'Perez-Borrego|Y A|YA|', 'Soto-León|V|V|', 'Gonzalez-Rosa|J J|JJ|', 'Higuero|A M|AM|', 'Strange|B A|BA|', 'Abad-Rodriguez|J|J|', 'Foffani|G|G|']
D000328:Adult D001288:Attention D002540:Cerebral Cortex D003071:Cognition D005260:Female D006801:Humans D008280:Magnetics D008297:Male D008875:Middle Aged D009483:Neuropsychological Tests D010751:Phosphopyruvate Hydratase D011597:Psychomotor Performance D009418:S100 Proteins D012449:Safety D050781:Transcranial Magnetic Stimulation D014705:Verbal Behavior D055815:Young Adult
Safety Transcranial static magnetic field stimulation (tSMS) Neuron-specific enolase S100 NIBS Repetitive transcranial magnetic stimulation (rTMS)