The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET.
Although amyloid imaging with PiB-PET ([C-11]Pittsburgh Compound-B positron emission tomography), and now with F-18-labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤ 45 years) and typical Alzheimer's disease patients. The units of this scale have been named "Centiloids." Basically, we describe a "standard" method of analyzing PiB PET data and then a method for scaling any "nonstandard" method of PiB PET analysis (or any other tracer) to the Centiloid scale.
['Klunk|William E|WE|', 'Koeppe|Robert A|RA|', 'Price|Julie C|JC|', 'Benzinger|Tammie L|TL|', 'Devous|Michael D|MD|', 'Jagust|William J|WJ|', 'Johnson|Keith A|KA|', 'Mathis|Chester A|CA|', 'Minhas|Davneet|D|', 'Pontecorvo|Michael J|MJ|', 'Rowe|Christopher C|CC|', 'Skovronsky|Daniel M|DM|', 'Mintun|Mark A|MA|']
D000368:Aged D000369:Aged, 80 and over D000544:Alzheimer Disease D000682:Amyloid D000814:Aniline Compounds D001921:Brain D002138:Calibration D019788:Fluorodeoxyglucose F18 D006801:Humans D007090:Image Interpretation, Computer-Assisted D008875:Middle Aged D058225:Plaque, Amyloid D049268:Positron-Emission Tomography D019275:Radiopharmaceuticals D013844:Thiazoles
Standardize Amyloid imaging Positron emission tomography Centiloid scale Pittsburgh compound B