The COngenital HeARt Disease in adult and Pulmonary Hypertension (COHARD-PH) registry: a descriptive study from single-center hospital registry of adult congenital heart disease and pulmonary hypertension in Indonesia.
BACKGROUNDS
The COngenital HeARt Disease in adult and Pulmonary Hypertension (COHARD-PH) registry is the first registry for congenital heart disease (CHD) and CHD-related pulmonary hypertension (PH) in adults in Indonesia. The study aims to describe the demographics, clinical presentation, and hemodynamics data of adult CHD and CHD-related PH in Indonesia.


METHODS
The COHARD-PH registry is a hospital-based, single-center, and prospective registry which includes adult patients with CHD and CHD-related PH. The patients were enrolled consecutively. For this study, we evaluated the registry patients from July 2012 until July 2019. The enrolled patients underwent clinical examination, electrocardiography, chest x-ray, 6-min walking test, laboratory measurement, and transthoracic and transesophageal echocardiography. Right heart catheterization was performed to measure hemodynamics and confirm the diagnosis of pulmonary artery hypertension (PAH).


RESULTS
We registered 1012 patients during the study. The majority were young, adult females. The majority of CHD was secundum ASD (73.4%). The main symptom was dyspnea on effort. The majority of patients (77.1%) had already developed signs of PH assessed by echocardiography. The Eisenmenger syndrome was encountered in 18.7% of the patients. Based on the right heart catheterization, 66.9% of patients had developed PAH. Patients with PAH were significantly older, had lower peripheral oxygen saturation, had lower 6-min walking distance, and higher NTproBNP. The NTproBNP level independently predicted the development of PAH among CHD.


CONCLUSIONS
The COHARD-PH registry is the first Indonesian adult-CHD and CHD-related PH registry. The demographics, clinical presentation, and hemodynamics dataof this registry reflect the situation in developing countries which needs to be compared with similar registries from developed countries.
['Dinarti|Lucia Kris|LK|', 'Hartopo|Anggoro Budi|AB|', 'Kusuma|Arditya Damar|AD|', 'Satwiko|Muhammad Gahan|MG|', 'Hadwiono|Muhammad Reyhan|MR|', 'Pradana|Aditya Doni|AD|', 'Anggrahini|Dyah Wulan|DW|']
D000328:Adult D004417:Dyspnea D005260:Female D006330:Heart Defects, Congenital D006439:Hemodynamics D006801:Humans D007214:Indonesia D008297:Male D008875:Middle Aged D011237:Predictive Value of Tests D015995:Prevalence D011379:Prognosis D011446:Prospective Studies D000081029:Pulmonary Arterial Hypertension D012042:Registries D055815:Young Adult
Pulmonary hypertension Registry Adult congenital heart disease Atrial septal defects