Prevention of UV-induced skin cancer in mice by gamma oryzanol-loaded nanoethosomes.
AIMS
Skin cancer is the most widespread cancer worldwide, mainly caused by exposure to ultraviolet radiation (UV) in sunlight. Utilizing topical preventive agents in routinely daily used cosmetics may prevent UV-related skin damages and skin cancers. γ-Oryzanol (GO) is a natural component derived from rice bran oil, with potential antioxidant and skin anti-aging properties.


MAIN METHODS
We biologically thorough studied the antioxidant and anticancer effects of GO in vitro to found the effective signaling pathways, then evaluated the sun protection factor of prepared formulation, and finally investigated the long-term preventive effects of GO-loaded nanoethosomes (GO-NEs) against UVB-induced skin cancer in mice.


KEY FINDINGS
GO-NEs could effectively prevent UVB-induced skin cancer.


SIGNIFICANCE
Our results suggest that GO-NEs could be utilized as an innovative ingredient in cosmetics.
['Zeinali|Mahdi|M|', 'Abbaspour-Ravasjani|Soheil|S|', 'Soltanfam|Tannaz|T|', 'Paiva-Santos|Ana Cláudia|AC|', 'Babaei|Hossein|H|', 'Veiga|Francisco|F|', 'Hamishehkar|Hamed|H|']
D000818:Animals D045744:Cell Line, Tumor D008297:Male D051379:Mice D008807:Mice, Inbred BALB C D049329:Nanostructures D010666:Phenylpropionates D012878:Skin Neoplasms D013473:Sunscreening Agents D014466:Ultraviolet Rays
Skin cancer Nanoethosomes γ-Oryzanol Melanoma UVB