Electric field causes volumetric changes in the human brain.
Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.
['Argyelan|Miklos|M|0000-0002-7254-1776', 'Oltedal|Leif|L|', 'Deng|Zhi-De|ZD|', 'Wade|Benjamin|B|', 'Bikson|Marom|M|', 'Joanlanne|Andrea|A|', 'Sanghani|Sohag|S|', 'Bartsch|Hauke|H|', 'Cano|Marta|M|0000-0003-0675-9483', 'Dale|Anders M|AM|', 'Dannlowski|Udo|U|', 'Dols|Annemiek|A|', 'Enneking|Verena|V|', 'Espinoza|Randall|R|', 'Kessler|Ute|U|', 'Narr|Katherine L|KL|', 'Oedegaard|Ketil J|KJ|', 'Oudega|Mardien L|ML|', 'Redlich|Ronny|R|', 'Stek|Max L|ML|', 'Takamiya|Akihiro|A|', 'Emsell|Louise|L|', 'Bouckaert|Filip|F|', 'Sienaert|Pascal|P|', 'Pujol|Jesus|J|', 'Tendolkar|Indira|I|', 'van Eijndhoven|Philip|P|', 'Petrides|Georgios|G|', 'Malhotra|Anil K|AK|', 'Abbott|Christopher|C|']
D000328:Adult D000368:Aged D000679:Amygdala D000928:Antidepressive Agents D001931:Brain Mapping D003863:Depression D004565:Electroconvulsive Therapy D060733:Electromagnetic Radiation D005260:Female D006624:Hippocampus D006801:Humans D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D009929:Organ Size D013702:Temporal Lobe
human neuroimaging ECT depression volume change electric field modeling human biology medicine