The association between body composition and cystatin C in South Asians: results from the MASALA study.
While South Asians have high rates of obesity and kidney disease, little is known about the effect of regional body composition on kidney function. We investigated the association between body composition measures and cystatin C-based estimated glomerular filtration rate (eGFRcysC) in 150 immigrant South Asians. The inverse association between overall adiposity and eGFRcysC was attenuated by C-reactive protein (CRP), while the association of ectopic fat was completely attenuated by metabolic covariates and CRP. In immigrant South Asians, the associations between overall adiposity and ectopic fat with decreased kidney function are largely explained by metabolic alterations and inflammation.
['Shah|Arti D|AD|', 'Schmidt|Heidi|H|', 'Sen|Saunak|S|', 'Shlipak|Michael G|MG|', 'Kanaya|Alka M|AM|']
D000273:Adipose Tissue D050154:Adiposity D000368:Aged D001208:Asia D044466:Asians D001823:Body Composition D002097:C-Reactive Protein D002140:California D003430:Cross-Sectional Studies D055316:Cystatin C D054242:Emigrants and Immigrants D005260:Female D005919:Glomerular Filtration Rate D006801:Humans D007249:Inflammation D007668:Kidney D008297:Male D024821:Metabolic Syndrome D008875:Middle Aged D009765:Obesity D051436:Renal Insufficiency, Chronic
Body composition Cystatin C South Asian Ectopic fat