The Neuroimmunology of Chronic Pain: From Rodents to Humans.
Chronic pain, encompassing conditions, such as low back pain, arthritis, persistent post-surgical pain, fibromyalgia, and neuropathic pain disorders, is highly prevalent but remains poorly treated. The vast majority of therapeutics are directed solely at neurons, despite the fact that signaling between immune cells, glia, and neurons is now recognized as indispensable for the initiation and maintenance of chronic pain. This review highlights recent advances in understanding fundamental neuroimmune signaling mechanisms and novel therapeutic targets in rodent models of chronic pain. We further discuss new technological developments to study, diagnose, and quantify neuroimmune contributions to chronic pain in patient populations.
['Grace|Peter M|PM|0000-0002-8999-1220', 'Tawfik|Vivianne L|VL|0000-0002-4422-2014', 'Svensson|Camilla I|CI|0000-0001-7980-4631', 'Burton|Michael D|MD|0000-0002-0628-824X', 'Loggia|Marco L|ML|0000-0002-8026-5265', 'Hutchinson|Mark R|MR|0000-0003-2154-5950']
D000818:Animals D001323:Autoantibodies D059350:Chronic Pain D004195:Disease Models, Animal D006801:Humans D051267:NF-E2-Related Factor 2 D009457:Neuroglia D015213:Neuroimmunomodulation D009474:Neurons D012377:Rodentia
Fc gamma receptors Nrf2 TSPO biomarkers cannabinoids sex differences