Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma.
Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are clinically disparate primary liver cancers with etiological and biological heterogeneity. We identified common molecular subtypes linked to similar prognosis among 199 Thai ICC and HCC patients through systems integration of genomics, transcriptomics, and metabolomics. While ICC and HCC share recurrently mutated genes, including TP53, ARID1A, and ARID2, mitotic checkpoint anomalies distinguish the C1 subtype with key drivers PLK1 and ECT2, whereas the C2 subtype is linked to obesity, T cell infiltration, and bile acid metabolism. These molecular subtypes are found in 582 Asian, but less so in 265 Caucasian patients. Thus, Asian ICC and HCC, while clinically treated as separate entities, share common molecular subtypes with similar actionable drivers to improve precision therapy.
['Chaisaingmongkol|Jittiporn|J|', 'Budhu|Anuradha|A|', 'Dang|Hien|H|', 'Rabibhadana|Siritida|S|', 'Pupacdi|Benjarath|B|', 'Kwon|So Mee|SM|', 'Forgues|Marshonna|M|', 'Pomyen|Yotsawat|Y|', 'Bhudhisawasdi|Vajarabhongsa|V|', 'Lertprasertsuke|Nirush|N|', 'Chotirosniramit|Anon|A|', 'Pairojkul|Chawalit|C|', 'Auewarakul|Chirayu U|CU|', 'Sricharunrat|Thaniya|T|', 'Phornphutkul|Kannika|K|', 'Sangrajrang|Suleeporn|S|', 'Cam|Maggie|M|', 'He|Ping|P|', 'Hewitt|Stephen M|SM|', 'Ylaya|Kris|K|', 'Wu|Xiaolin|X|', 'Andersen|Jesper B|JB|', 'Thorgeirsson|Snorri S|SS|', 'Waterfall|Joshua J|JJ|', 'Zhu|Yuelin J|YJ|', 'Walling|Jennifer|J|', 'Stevenson|Holly S|HS|', 'Edelman|Daniel|D|', 'Meltzer|Paul S|PS|', 'Loffredo|Christopher A|CA|', 'Hama|Natsuko|N|', 'Shibata|Tatsuhiro|T|', 'Wiltrout|Robert H|RH|', 'Harris|Curtis C|CC|', 'Mahidol|Chulabhorn|C|', 'Ruchirawat|Mathuros|M|', 'Wang|Xin W|XW|', '|||']
D044466:Asians D006528:Carcinoma, Hepatocellular D018281:Cholangiocarcinoma D016000:Cluster Analysis D006801:Humans D053208:Kaplan-Meier Estimate D008113:Liver Neoplasms D011379:Prognosis D059467:Transcriptome
molecular subtypes hepatocellular carcinoma intrahepatic cholangiocarcinoma liver cancer transcriptomics metabolomics TIGER-LC cancer driver cancer genomics integrated genomics