Roles of Albumin-Binding Proteins in Cancer Progression and Biomimetic Targeted Drug Delivery.
Nutrient transporters have attracted significant attention for their promising application in biomimetic delivery. Due to the active consumption of nutrients, cancer cells generally overexpress nutrient transporters to meet their increased need for energy and materials. For example, albumin-binding proteins (ABPs) are highly overexpressed in malignant cells, stromal cells, and tumor vessel endothelial cells responsible for albumin uptake. ABP (e.g., SPARC) is a promising target for tumor-specific drug delivery, and albumin has been widely used as a biomimetic delivery carrier. Apart from the transportation function, ABPs are closely associated with neoplasia, invasion, and metastasis. Herein, a summary of the roles of ABP in cancer progression and the application of albumin-based biomimetic tumor-targeted delivery through the ABP pathway is presented.
['Zhao|Pengfei|P|', 'Wang|Yonghui|Y|', 'Wu|Aihua|A|', 'Rao|Yuefeng|Y|', 'Huang|Yongzhuo|Y|0000-0001-7067-8915']
D000818:Animals D000970:Antineoplastic Agents D032701:Biomimetics D002352:Carrier Proteins D045744:Cell Line, Tumor D004337:Drug Carriers D006023:Glycoproteins D034441:Heterogeneous-Nuclear Ribonucleoproteins D006801:Humans D053758:Nanoparticles D009369:Neoplasms D011956:Receptors, Cell Surface D012709:Serum Albumin
albumin-binding proteins cancer drug delivery nutrient transporters biomimetic delivery