Flavonoids from Varronia dardani (Taroda) J.S. Mill (cordiaceae) and the evaluation of spasmolytic activity of its crude ethanolic extract.
Pharmacological studies show spasmolytic activity for various species of Varronia. Thus, based on the taxonomy criteria, the aim of this study was to contribute to chemical and biological knowledge, especially regarding the evaluation of spasmolytic activity of the ethanolic extract from Varronia dardani leaves (VD-EtOHL) on rat aorta and trachea, guinea-pig ileum and rat uterus. Were used High and Medium Performance Liquid Chromatography. Wistar rats and guinea-pigs were used for pharmacological assays. All experimental protocols were approved by Animal Ethics Committee of UFPB (126/2017). Two chalcones (pinostrobin chalcone and gymnogrammene), five flavanones (pinocembrin, isosakuranetin, pinostrobin, sakuranetin 4'-methyl ether, naringenin) and a flavonoid glycosilated (astragalin) were identified based on data of 1H and 13C Nuclear Magnetic Resonance. This study also showed that VD-EtOHL has a non-selective spasmolytic activity, presenting greater relaxing potency in rat uterus, suggesting that flavonoids isolated from VD-EtOHL may be responsible for spasmolytic activity of this extract.
['G Veloso|Carlos Arthur|CA|0000-0003-4917-6106', 'Alencar D Figueiredo|Indyra|I|', 'da Silva|Gleice Rayanne|GR|', 'Miranda de Melo|José Iranildo|JI|', 'S da Silva|Marcelo|M|', 'Tavares|Josean F|JF|', 'de A Cavalcante|Fabiana|F|', 'de O Costa|Vicente Carlos|VC|']
D000818:Animals D005419:Flavonoids D006168:Guinea Pigs D007082:Ileum D019684:Magnoliopsida D009119:Muscle Contraction D010276:Parasympatholytics D010936:Plant Extracts D051381:Rats D017208:Rats, Wistar
spasmolytic activity chalcones Flavanones smooth muscle