Macrophages and T cells in atherosclerosis: a translational perspective.
Atherosclerosis is now considered a chronic maladaptive inflammatory disease. The hallmark feature in both human and murine disease is atherosclerotic plaques. Macrophages and various T-cell lineages play a crucial role in atherosclerotic plaque establishment and disease progression. Humans and mice share many of the same processes that occur within atherogenesis. The various similarities enable considerable insight into disease mechanisms and those which contribute to cardiovascular complications. The apolipoprotein E-null and low-density lipoprotein receptor-null mice have served as the foundation for further immunological pathway manipulation to identify pro- and antiatherogenic pathways in attempt to reveal more novel therapeutic targets. In this review, we provide a translational perspective and discuss the roles of macrophages and various T-cell lineages in contrasting proatherosclerotic and atheroprotective settings.
['Bartlett|Benjamin|B|', 'Ludewick|Herbert P|HP|', 'Misra|Ashish|A|', 'Lee|Silvia|S|', 'Dwivedi|Girish|G|0000-0003-0717-740X']
D000818:Animals D001158:Arteries D050197:Atherosclerosis D019070:Cell Lineage D016207:Cytokines D006801:Humans D008213:Lymphocyte Activation D008262:Macrophage Activation D008264:Macrophages D010641:Phenotype D058226:Plaque, Atherosclerotic D015398:Signal Transduction D016176:T-Lymphocyte Subsets D057170:Translational Research, Biomedical
macrophages T cells atherosclerosis atherogenesis