Effect of garlic powder supplementation on hepatic steatosis, liver enzymes and lipid profile in patients with non-alcoholic fatty liver disease: a double-blind randomised controlled clinical trial.
Non-alcoholic fatty liver disease (NAFLD) includes a range of disorders from simple steatosis to non-alcoholic steatohepatitis. There is no proven drug treatment for NAFLD, and diet modification is considered part of the main line of treatment for this disease. The aim of this study was to investigate the efficacy of garlic supplementation in NAFLD patients. The effect of garlic powder supplementation on hepatic steatosis, liver enzymes and lipid profile was investigated in NAFLD patients. Ninety NAFLD patients were randomly assigned to take either a garlic powder supplement or a placebo for 12 weeks. The treatment group received four tablets of garlic daily (each tablet contained 400 mg garlic powder). The control group received four tablets of placebo (each placebo contained 400 mg starch). At the end of the study, hepatic steatosis was significantly reduced in the treatment group compared with the control group (P = 0·001). In addition, a significant decrease was seen in the serum concentration of alanine transaminase (P < 0·001), aspartate transaminase (P = 0·002), γ-glutamyltransferase (P = 0·003) as well as total cholesterol (P = 0·009), TAG (P < 0·001), HDL-cholesterol (P < 0·001) and LDL-cholesterol (P = 0·01) in the treatment group compared with the control group. No significant difference was seen between the two groups in serum concentration of alkaline phosphatase. Overall, garlic powder supplementation improved hepatic features and lipid profile among NAFLD patients.
['Sangouni|Abbas Ali|AA|', 'Mohammad Hosseini Azar|Mohammad Reza|MR|', 'Alizadeh|Mohammad|M|0000-0002-0593-1491']
D000328:Adult D000410:Alanine Transaminase D000469:Alkaline Phosphatase D001219:Aspartate Aminotransferases D019587:Dietary Supplements D004311:Double-Blind Method D005260:Female D005737:Garlic D006801:Humans D008055:Lipids D008099:Liver D008297:Male D008875:Middle Aged D065626:Non-alcoholic Fatty Liver Disease D016896:Treatment Outcome D005723:gamma-Glutamyltransferase
Garlic Hepatic steatosis Liver enzymes Lipid profile Non-alcoholic fatty liver disease