Sequelae of AKI.
Large epidemiologic studies in a variety of patient populations reveal increased morbidity and mortality that occur months to years after an episode of acute kidney injury (AKI). Even milder forms of AKI have increased associated morbidity and mortality. Residual confounding may account for these findings, but considering the huge number of individuals afflicted with AKI, the sequelae of AKI may be a very large public health burden. AKI may simply be a marker for increased risk, but there is increasing evidence that it is part of the causal pathway to chronic kidney disease. These studies have upended the traditional view that AKI survivors who returned to baseline, or near baseline renal function, do not suffer additional long-term consequences. Recovery of renal function after AKI, short of independence from renal replacement therapy, is yet to be clearly defined but may be of significant importance in the management of AKI survivors. The association between AKI in patients who undergo cardiac surgery and clinical outcomes is of considerable importance to clinicians, surgeons, and anesthesiologists alike and is a major focus of this review.
['Patel|Samir S|SS|', 'Palant|Carlos E|CE|', 'Mahajan|Vrinda|V|', 'Chawla|Lakhmir S|LS|']
D058186:Acute Kidney Injury D000818:Animals D006348:Cardiac Surgical Procedures D018450:Disease Progression D006801:Humans D007677:Kidney Function Tests D020127:Recovery of Function D051436:Renal Insufficiency, Chronic D017582:Renal Replacement Therapy D017741:Survivors D013997:Time Factors
epidemiologic studies acute kidney injury cardiac surgical procedures cardiovascular diseases follow-up studies