Elevated immunoexpression of interferon-gamma in placenta tissue samples from pregnancies complicated with preeclampsia compared to the placenta previa.
AIM
The present study aimed to compare the immunohistochemical expression of interferon-gamma (IFN-γ) in placentas from pregnancies complicated with preeclampsia (PE) and placenta previa (PP) and normal healthy placentas.


METHODS
Placentas were collected from cases of PE, PP and normal pregnancies as a control group (10 placentas in each group). All the deliveries were at full-term (37-42 weeks) by cesarean section and newborns were without any complications or diseases. Expression of IFN-γ in the placenta was determined using immunohistochemical methods and findings were compared. Statistical analysis was performed by Mann-Whitney and Kruskal-Wallis tests for comparing the mean values of IFN-γ expression in the placentas from PE, PP and control groups. Our results showed that the immunoexpression of IFN-γ in syncytiotrophoblast cells, extravillous trophoblast cells, vascular endothelium and basal plate of the placenta from PE group were more than control and PP groups (P < 0.05) and in PP group were more than the control group (P < 0.05).


CONCLUSION
We concluded that the immunoexpression of IFN-γ was increased significantly in placenta tissue samples of the PE group compared to the PP group and normal pregnancies. It is proposed that IFN-γ has an important role in the different mechanisms of PE and PP progression.
['Sheibak|Nadia|N|', 'Mahmoudzadeh-Sagheb|Hamidreza|H|', 'Moudi|Bita|B|', 'Heidari|Zahra|Z|']
D000328:Adult D016022:Case-Control Studies D005260:Female D006801:Humans D007371:Interferon-gamma D010923:Placenta Previa D011225:Pre-Eclampsia D011247:Pregnancy D014327:Trophoblasts
Interferon-gamma Pregnancy complications Preeclampsia Placenta previa Trophoblast