Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands: From Previously Reported Berberine Derivatives to New Palmatine Analogues.
In this paper, the selective interactions of synthetic derivatives of two natural compounds, berberine and palmatine, with DNA G-quadruplex structures were reported. In particular, the previous works on this subject concerning berberine were further presented and discussed, whereas the results concerning palmatine are presented here for the first time. In detail, these palmatine derivatives were developed by inserting seven different small peptide basic chains, giving several new compounds that have never been reported before. The preliminary studies of the interactions of these compounds with various G-quadruplex-forming sequences were carried out by means of various structural and biochemical techniques, which showed that the presence of suitable side chains is very useful for improving the interaction of the ligands with G-quadruplex structures. Thus, these new palmatine derivatives might act as potential anticancer drugs.
['Franceschin|Marco|M|', 'Cianni|Lorenzo|L|', 'Pitorri|Massimo|M|', 'Micheli|Emanuela|E|', 'Cacchione|Stefano|S|', 'Frezza|Claudio|C|0000-0002-2968-5264', 'Serafini|Mauro|M|', 'Hu|Ming-Hao|MH|', 'Su|Huafi|H|', 'Huang|Zhishu|Z|', 'Gu|Lianquan|L|', 'Bianco|Armandodoriano|A|']
D001599:Berberine D001600:Berberine Alkaloids D004247:DNA D054856:G-Quadruplexes D008024:Ligands D008958:Models, Molecular D015394:Molecular Structure
interactions FRET and MST assays G-quadruplex DNA NMR berberine and palmatine derivatives