Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence.
Complex and coordinated signals are necessary to initiate and sustain the activation, proliferation, and differentiation of lymphocytes. These signals, which are known to determine T-cell fate and function, also depend on the metabolic state of the organism. Recent studies indicate that both the type and levels of nutrients can influence the generation, survival and function of lymphocytes and therefore can affect several autoimmune diseases. Here, we review the dysregulation of lymphocytes during autoimmunity and aging, the mechanisms associated with loss of immune function, and how fasting mimicking diets and other dietary interventions affect autoimmunity and immunosenescence.
['Choi|In Young|IY|', 'Lee|Changhan|C|', 'Longo|Valter D|VD|']
D000375:Aging D000818:Animals D001172:Arthritis, Rheumatoid D001327:Autoimmune Diseases D031204:Caloric Restriction D003922:Diabetes Mellitus, Type 1 D004032:Diet D004195:Disease Models, Animal D005215:Fasting D006801:Humans D000068884:Immunosenescence D051379:Mice D009103:Multiple Sclerosis D009752:Nutritional Status D013601:T-Lymphocytes
Fasting Fasting mimicking diet Autoimmune diseases Immunosenescence Metabolism Aging