Role of routine blood tests for predicting clinical outcomes in osteosarcoma patients.
BACKGROUND
This retrospective cohort study aimed to investigate whether simple routine blood tests at presentation (C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), alkaline phosphatase and albumin) predict survival in patients with osteosarcoma.


METHODS
Between January 1998 and February 2015, 134 patients with a histological diagnosis of osteosarcoma were treated in our unit. Of these, 79 patients with high-grade osteosarcomas were included in the study. Demographic and clinical data, and laboratory parameters obtained prior to biopsy (CRP, ESR, alkaline phosphatase and albumin levels), were obtained from patients' records.


RESULTS
There were 44 males and 35 females. Univariate analysis showed that high pre-biopsy CRP ( p = 0.004), raised pre-biopsy ESR ( p = 0.010), older age ( p < 0.001), poor tumour necrosis rates (≤90%, p = 0.023) and metastasis at presentation ( p < 0.001) were poor prognostic factors. Multivariate analysis showed pre-biopsy CRP and ESR levels to be independent predictors of overall survival ( p = 0.020 and p = 0.025, respectively). Kaplan-Meier survival was significantly lower in patients with elevated CRP ( p = 0.002) and ESR ( p = 0.003). Hypoalbuminaemia and elevated alkaline phosphatase levels did not correlate with overall survival.


CONCLUSION
Preoperative CRP and ESR levels may have value in building a prognostic model for patients presenting with osteosarcoma.
['Jettoo|P|P|0000-0002-9849-6598', 'Tan|Gjs|G|', 'Gerrand|C H|CH|', 'Rankin|K S|KS|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D000469:Alkaline Phosphatase D001706:Biopsy D001799:Blood Sedimentation D001859:Bone Neoplasms D002097:C-Reactive Protein D002648:Child D002675:Child, Preschool D003955:Diagnostic Tests, Routine D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D012516:Osteosarcoma D011237:Predictive Value of Tests D011379:Prognosis D012189:Retrospective Studies D015996:Survival Rate D055815:Young Adult
clinical outcome osteosarcoma C-reactive protein erythrocyte sedimentation rate