Utility of lateral flow tests in SARS-CoV-2 infection monitorization.
OBJECTIVE
The diagnosis of SARS-CoV-2 infection is crucial for medical and public health reasons, to allow the best treatment of cases and the best control of the pandemic. Serology testing allows for the detection of asymptomatic infections and 19-COVID cases once the virus has been cleared. We analyzed the usefulness of the SARS-CoV-2 rapid test of Autobio and tried to correlate its pattern with the severity of COVID19 infection.


METHODS
We analyzed the accuracy and clinical usefulness of a point-of-care IgM and/or IgG test for SARS-CoV-2 in 35 COVID-19 patients [12 (34.3%) mild-moderate and 23 (65.7%) severe-critical] admitted to a field hospital in Madrid, as well as in 5 controls.


RESULTS
The mean time from the first day of symptoms to the antibody test was 28 days (SD: 8.7), similar according to the severity of the disease. All patients with SARS-CoV-2 PCR+ showed the corresponding IgG positivity, while these results were negative in all control individuals. A total of 26 (74%) cases also presented with positive IgM, 19 (83%) were severe-critical cases and 7 (58%) were mild-moderate cases. The IgM response lasted longer in the severe critical cases (mean: 29.7 days; SD: 8.4) compared to the moderate cases (mean: 21.2 days; SD: 2.0)..


CONCLUSIONS
Rapid serology tests are useful for the diagnosis of patients with COVID-19 (mainly IgG detection) and may also be correlated with the severity of the infection (based on IgM detection).
['Candel|F J|FJ|', 'Viñuela-Prieto|J M|JM|', 'González Del Castillo|J|J|', 'Barreiro García|P|P|', 'Fragiel Saavedra|M|M|', 'Hernández Píriz|A|A|', 'Jiménez Virumbrales|D|D|', 'Canora Lebrato|J|J|', 'García de Casasola|G|G|', 'Gil Prieto|R|R|', 'San-Román Montero|J|J|', 'Ortega Anselmi|J|J|', 'Barba Martín|R|R|', 'Prados Roa|F|F|', 'Marco Martínez|J|J|', 'Zapatero Gaviria|A|A|']
D000328:Adult D000368:Aged D000914:Antibodies, Viral D058345:Asymptomatic Infections D000073640:Betacoronavirus D000086382:COVID-19 D000086742:COVID-19 Testing D019411:Clinical Laboratory Techniques D018352:Coronavirus Infections D003430:Cross-Sectional Studies D005260:Female D006801:Humans D007118:Immunoassay D007074:Immunoglobulin G D007075:Immunoglobulin M D008297:Male D008875:Middle Aged D058873:Pandemics D011024:Pneumonia, Viral D000067716:Point-of-Care Testing D020133:Reverse Transcriptase Polymerase Chain Reaction D000086402:SARS-CoV-2 D012680:Sensitivity and Specificity D012720:Severity of Illness Index D063189:Symptom Assessment D013997:Time Factors
SARS-CoV-2 Autobio COVID-19 infection Serologic rapid tests weak positive bands