Protective role of jaboticaba Plinia peruviana peel extract in copper-induced cytotoxicity in Allium cepa.
Jaboticaba Plinia peruviana (Poir.) Govaerts is a Brazilian berry that presents high levels of polyphenols, which may play a key role in preventing cytotoxic and genotoxic effects of harmful agents. Although copper is an essential micronutrient that plays an important role in organisms, high copper concentrations may trigger toxicity to animals and plants. Here, we investigated whether Plinia peruviana hydroalcoholic extract prevents copper-induced cytotoxicity in Allium cepa root cells. Five different anthocyanins and phenolic compounds were identified in Plinia peruviana extract. Importantly, the exposure to 1.53 mg/L copper for 24 h impaired mitotic index, as well as increased mitosis disturbances and triggered DNA damage. Pre-incubation with Plinia peruviana extract (0.25 g/L and 0.75 g/L) for 3 h prevented copper-induced changes in the mitotic index and reduced the number of abnormal cells. In conclusion, we suggest that Plinia peruviana peel extract has protective effects against cellular and genetic disturbances induced by copper.
['Franscescon|Francini|F|', 'Mazon|Samara C|SC|', 'Bertoncello|Kanandra T|KT|', 'Boligon|Aline A|AA|', 'Sachett|Adrieli|A|', 'Rambo|Cassiano L|CL|', 'Rosemberg|Denis B|DB|', 'Magro|Jacir Dal|JD|', 'Siebel|Anna M|AM|http://orcid.org/0000-0002-7896-1456']
D000818:Animals D000872:Anthocyanins D001938:Brazil D003300:Copper D004249:DNA Damage D004785:Environmental Pollutants D005638:Fruit D008940:Mitotic Index D008962:Models, Theoretical D027822:Myrtaceae D019697:Onions D010936:Plant Extracts D059808:Polyphenols
Protection Polyphenols Anthocyanins Mitotic index DNA damage Copper toxicity