Novel NF-κB inhibitors: a patent review (2011 - 2014).
IMPORTANCE OF THE FIELD
The NF-κB family of transcription factors has a vital role in coordinating the expression of a wide variety of genes that control immune responses. The dysfunction of NF-κB has been associated with diseases ranging from inflammation to cancer.


AREAS COVERED
In this review, authors provided information on the role of NF-κB in human health and on recently developed inhibitors from patents granted in 2011 - 2014. The reader will gain an understanding of the mechanisms of NF-κB function as well as the structures and biological activities of recently developed NF-κB inhibitors.


EXPERT OPINION
Constitutive NF-κB activation is likely involved in the pathogenesis of several diseases. Researchers need to consider the specific mechanism of each invented NF-κB inhibitor, as well as the properties of the cellular, in vitro and in vivo assays and targeted diseases. For new drug development, they need various biological tests to assess the potential side effects and optimization of the biological activity.
['Arepalli|Sateesh Kumar|SK|', 'Choi|Minho|M|', 'Jung|Jae-Kyung|JK|', 'Lee|Heesoon|H|']
D000818:Animals D015195:Drug Design D005786:Gene Expression Regulation D006801:Humans D007249:Inflammation D016328:NF-kappa B D009369:Neoplasms D010330:Patents as Topic
NF-κB inhibitors immune responses anti-inflammation antitumor effects