Effects of oxygenated polycyclic aromatic hydrocarbons on the early life stages of Japanese medaka.
Oxygenated polycyclic aromatic hydrocarbons (oxyPAHs) are directly discharged into the atmosphere with exhaust gas from diesel engine automobiles and industry and are also generated by photo-oxidation and/or microbial metabolism of parent polycyclic aromatic hydrocarbons (PAHs). They are widely distributed in environment, especially around urban areas. We evaluated the effects of exposure to oxyPAHs as acenaphthenequinone (ANQ), 7,12-benz(a)anthracenequinone (BAQ), 1,4-naphthoquinone (NAQ), and 9,10-phenanethrenequinone (PHQ) in Japanese medaka (Oryzias latipes) embryos. ANQ (>2720 μg/L) caused caving in the yolk sac, and BAQ (>22.4 μg/L) caused tanning of the oil droplet. Additionally, NAQ (>314 μg/L) and PHQ (>734 μg/L) stopped development of medaka embryos beginning 2 days after the start of exposure. The hatched larvae from embryos exposed to ANQ, BAQ, NAQ, or PHQ at 518, 9.86, 36.5, or 80.7 μg/L, respectively, exhibited incomplete development of the cephalic region, incomplete palate, unabsorbed and hypertrophied yolk sac, tubular heart, altered axial curvature, and poor swimming ability. These symptoms were similar to those observed in blue sac disease, which is caused by exposure to PAHs.
['Kawano|Machi|M|', 'Uno|Seiichi|S|', 'Koyama|Jiro|J|', 'Kokushi|Emiko|E|', 'McElroy|Anne|A|']
D000818:Animals D004625:Embryo, Nonmammalian D007814:Larva D009990:Oryzias D010100:Oxygen D011084:Polycyclic Aromatic Hydrocarbons D014874:Water Pollutants, Chemical
Medaka oxyPAH Embryo Malformation Morphological Toxicology