Ethical review of biobank research: Should RECs review each release of material from biobanks operating under an already-approved broad consent and data protection model?
BACKGROUND
The use of broad consent in biobank research has implications for the procedures of ethics review. This paper describes these implications and makes a recommendation for how to deal with them.


ANALYSIS
Two steps in the ethics review of biobank research can be distinguished. In a first step, a research ethics committee (REC) reviews a biobank's framework regarding oversight procedures (e.g. broad consent form and data protection model). A second step then reviews specific projects that require the release of particular biomaterial and/or data. This paper argues that only a few research-related risks remain for the second step of ethical review and that a self-regulated body such as a biobank internal access committee would suffice (in principle) to address these risks.


CONCLUSION
The reduction of REC involvement in biobank research proposed here has three aims: (i) to conserve time and money, (ii) to allow RECs to focus on higher-risk areas, and (iii) to promote professional self-regulation. Assuming that the public understands that neither REC involvement nor competent access committees can guarantee 100% protection against misuse of data, the proposed reduction of REC involvement could also enhance the public perception of biobank research as an ethically-sensitive enterprise that can be sufficiently controlled through competent self-regulation. In order to compensate for reduced REC involvement and to maintain public trust, biobanks should implement safeguards such as public information on approved projects.
['Strech|Daniel|D|']
D026683:Advisory Committees D018070:Biological Specimen Banks D016494:Computer Security D007258:Informed Consent
Ethics review Biobank Broad consent Research ethics committee Access committee Approval Biospecimens Data access