Sigma-1 receptor chaperones in neurodegenerative and psychiatric disorders.
INTRODUCTION
Sigma-1 receptors (Sig-1Rs) are molecular chaperones that reside mainly in the endoplasmic reticulum (ER) but exist also in the proximity of the plasma membrane. Sig-1Rs are highly expressed in the CNS and are involved in many cellular processes including cell differentiation, neuritogenesis, microglia activation, protein quality control, calcium-mediated ER stress and ion channel modulation. Disturbance in any of the above cellular processes can accelerate the progression of many neurological disorders; therefore, the Sig-1R has been implicated in several neurological diseases.


AREAS COVERED
This review broadly covers the functions of Sig-1Rs including several neurodegenerative disorders in humans and drug addiction-associated neurological disturbance in the case of HIV infection. We discuss how several Sig-1R ligands could be utilized in therapeutic approaches to treat those disorders.


EXPERT OPINION
Emerging understanding of the cellular functions of this unique transmembrane chaperone may lead to the use of new agents or broaden the use of certain available ligands as therapeutic targets in those neurological disorders.
['Tsai|Shang-Yi A|SY|', 'Pokrass|Michael J|MJ|', 'Klauer|Neal R|NR|', 'De Credico|Nicole E|NE|', 'Su|Tsung-Ping|TP|']
D000818:Animals D016503:Drug Delivery Systems D006801:Humans D001523:Mental Disorders D018832:Molecular Chaperones D009292:Narcotic Antagonists D019636:Neurodegenerative Diseases D017480:Receptors, sigma
sigma-1 receptor psychiatric disorders Alzheimer’s disease HIV-associated neurodementia Parkinson’s disease amyotrophic lateral sclerosis frontotemporal lobar degeneration neurodegenerative diseases