Comparison of Best Medical Management with Carotid Intervention Procedures in the Prevention of Stroke Recurrence in Patients with Symptomatic Internal Carotid Artery Stenosis.
Background
As per the current recommendations, carotid interventional procedures (carotid endarterectomy/carotid artery stenting) are considered superior to medical management in reducing the stroke recurrence in patients with symptomatic extracranial internal carotid artery (ICA) stenosis.


Objective
The objective of this study is to compare the best medical management with carotid interventional procedures in the prevention of stroke recurrence in the patients with symptomatic extracranial ICA stenosis.


Materials and Methods
This was a parallel, prospective, two-arm, open-label, observational study. Participants were selected consecutively and prospectively among patients from Outpatient and Inpatient Departments of Neurology at Nizam's Institute of Medical Sciences, Hyderabad, Telangana, India. The study period was from January 2012 to December 2017.


Results
Of 150 patients with symptomatic extracranial ICA stenosis of ≥50%, 100 preferred best medical management (m = 75, f = 25) and 50 (m = 37, f = 13) opted for carotid intervention. The mean age of the patient cohort was 59.8 ± 12.7. Follow-up was done at regular intervals from 3 months to 1 year. In the medical group, the recurrence occurred in 10 patients; 4 (40%) within 6 months, 5 (50%) within 6-12 months, and 1 (10%) after 1 year. In the intervention group, the recurrence occurred in 6 patients; 5 (83%) within the first 6 months and 1 (17%) within 6-12 months.


Conclusions
Overall, there was no statistically significant difference in the rate of recurrence between the best medical management and the carotid interventional procedures.
['Deepa Rani|B V|BV|', 'Gampa|Sandeep|S|', 'Sirineni|Deepika|D|', 'Harshavardhana|K R|KR|', 'Krishna|Satya Rama|SR|', 'Kaul|Subhash|S|']
Best medical management carotid intervention carotid artery stenosis Hyderabad India