Validation of an administrative claims-based diagnostic code for pneumonia in a US-based commercially insured COPD population.
OBJECTIVE
To estimate the accuracy of claims-based pneumonia diagnoses in COPD patients using clinical information in medical records as the reference standard.


METHODS
Selecting from a repository containing members' data from 14 regional United States health plans, this validation study identified pneumonia diagnoses within a group of patients initiating treatment for COPD between March 1, 2009 and March 31, 2012. Patients with ≥1 claim for pneumonia (International Classification of Diseases Version 9-CM code 480.xx-486.xx) were identified during the 12 months following treatment initiation. A subset of 800 patients was randomly selected to abstract medical record data (paper based and electronic) for a target sample of 400 patients, to estimate validity within 5% margin of error. Positive predictive value (PPV) was calculated for the claims diagnosis of pneumonia relative to the reference standard, defined as a documented diagnosis in the medical record.


RESULTS
A total of 388 records were reviewed; 311 included a documented pneumonia diagnosis, indicating 80.2% (95% confidence interval [CI]: 75.8% to 84.0%) of claims-identified pneumonia diagnoses were validated by the medical charts. Claims-based diagnoses in inpatient or emergency departments (n=185) had greater PPV versus outpatient settings (n=203), 87.6% (95% CI: 81.9%-92.0%) versus 73.4% (95% CI: 66.8%-79.3%), respectively. Claims-diagnoses verified with paper-based charts had similar PPV as the overall study sample, 80.2% (95% CI: 71.1%-87.5%), and higher PPV than those linked to electronic medical records, 73.3% (95% CI: 65.5%-80.2%). Combined paper-based and electronic records had a higher PPV, 87.6% (95% CI: 80.9%-92.6%).


CONCLUSION
Administrative claims data indicating a diagnosis of pneumonia in COPD patients are supported by medical records. The accuracy of a medical record diagnosis of pneumonia remains unknown. With increased use of claims data in medical research, COPD researchers can study pneumonia with confidence that claims data are a valid tool when studying the safety of COPD therapies that could potentially lead to increased pneumonia susceptibility or severity.
['Kern|David M|DM|', 'Davis|Jill|J|', 'Williams|Setareh A|SA|', 'Tunceli|Ozgur|O|', 'Wu|Bingcao|B|', 'Hollis|Sally|S|', 'Strange|Charlie|C|', 'Trudo|Frank|F|']
D000328:Adult D000368:Aged D000553:Ambulatory Care D000900:Anti-Bacterial Agents D003132:Commerce D057225:Data Mining D057286:Electronic Health Records D004636:Emergency Service, Hospital D005260:Female D006801:Humans D007297:Inpatients D007345:Insurance Claim Review D007348:Insurance, Health D038801:International Classification of Diseases D008297:Male D008875:Middle Aged D011014:Pneumonia D011237:Predictive Value of Tests D015203:Reproducibility of Results D012189:Retrospective Studies D014481:United States
validation pneumonia positive predictive value claims data medical record review