Urinary Cell-Free DNA: Potential and Applications.
Urine could be a convenient source of biomarkers for different diseases and clinical applications, mostly for cancer diagnosis, prognosis, treatment monitoring, and prenatal diagnosis. The ultra-noninvasive sampling and the possibility to analyze large volume are the main undisputed advantages of urine-based protocols. Recent and comprehensive studies showed that urinary cell-free DNA (ucfDNA) is informative to identify the genomic signature of patients, resulting in a huge tool to track the tumor evolution and for personalized medicine in urological and non-urological cancer.In this chapter, we reported the main published evidences on ucfDNA, with the aim at discussing its promising and translatable role in clinical practices.
['Salvi|Samanta|S|', 'Casadio|Valentina|V|']
D000818:Animals D000073888:Cell-Free Nucleic Acids D056915:DNA Copy Number Variations D005260:Female D006801:Humans D009154:Mutation D009369:Neoplasms D016133:Polymerase Chain Reaction D011247:Pregnancy D011296:Prenatal Diagnosis D011379:Prognosis D059349:Urine Specimen Collection
Urinary cell-free DNA Urine Cancer diagnosis Cancer monitoring Fetal urinary cell-free DNA