The Effect of Prophylactic HPV Vaccines on Oral and Oropharyngeal HPV Infection-A Systematic Review.
Human papillomavirus (HPV) imposes an increased risk of developing cervical, anal and oropharyngeal cancer. In the Western world, HPV infection is currently the major cause of oropharyngeal cancer. The effectiveness of HPV vaccines for oral or oropharyngeal HPV infection is yet to be determined. This study conducted a systematic literature search in Pubmed and Embase. Studies investigating the impact of HPV vaccines on oral or oropharyngeal HPV infection were enrolled. This review reports the relative prevention percentage (RPP), including a risk of bias assessment as well as a quality assessment study. Nine studies were included (48,777 participants): five cross-sectional studies; one randomized community trial study (RCT); one longitudinal cohort study; and two case-control studies. A significant mean RPP of 83.9% (66.6-97.8%) was calculated from the cross-sectional studies, 82.4% in the included RCT and 83% in the longitudinal cohort study. Further, two case-control studies that measured antibody response in participants immunized with HPV vaccines were included. Respectively, 100% and 93.2% of participants developed HPV-16 Immunoglobulin G (IgG) antibodies in oral fluids post-vaccination. Analysis of the studies identified a significant decrease in vaccine-type oral or oropharyngeal HPV infections in study participants immunized with HPV vaccines across study designs and heterogenous populations. Further, a significant percentage of participants developed IgG antibodies in oral fluid post-vaccination.
['Nielsen|Kristoffer Juul|KJ|', 'Jakobsen|Kathrine Kronberg|KK|', 'Jensen|Jakob Schmidt|JS|', 'Grønhøj|Christian|C|', 'Von Buchwald|Christian|C|']
D052685:Alphapapillomavirus D016022:Case-Control Studies D003430:Cross-Sectional Studies D005260:Female D006801:Humans D008137:Longitudinal Studies D008297:Male D009055:Mouth D009062:Mouth Neoplasms D009959:Oropharyngeal Neoplasms D009960:Oropharynx D027383:Papillomaviridae D030361:Papillomavirus Infections D053918:Papillomavirus Vaccines D065129:Pre-Exposure Prophylaxis D014611:Vaccination
vaccines human papillomavirus oropharyngeal cancer head and neck cancer oncology