REM sleep deprivation impairs retrieval, but not reconsolidation, of methamphetamine reward memory in male rats.
Susceptibility to interference can be a result of memory retrieval and reconsolidation. Given the fact that addiction develops through the neural mechanisms of learning and memory, it would not be surprising that a consolidated drug reward memory may also be susceptible to interference following retrieval/reconsolidation. Due to the critical role of sleep in memory consolidation, sleep deprivation (SD) has been shown to impair memory. Therefore, the major objective of this study was to investigate the effect of rapid eye movement (REM) sleep deprivation (RSD) on the retrieval and reconsolidation of methamphetamine (METH) reward memory in male rats. The animals were trained to acquire METH-induced CPP (2 mg/kg, i.p.). METH reward memory was then reactivated/retrieved in the drug-paired chamber during a drug-free (memory reactivation) session. A period of 48-h RSD paradigm using the multiple platform technique resulted in persistent deficits in the retrieval of METH reward memory. Nevertheless, the same protocol of RSD, which was conducted immediately after the memory reactivation, did not affect the reconsolidation of METH reward memory. Additionally, the RSD episode induced a temporary potentiation of METH-induced hyperlocomotion. Our findings would seem to suggest that sleep is involved in the retrieval, but not reconsolidation, of METH reward memory. The results may also demonstrate that RSD mimics the effects of METH on locomotor activity. The results of this study, therefore, support the idea that sleep is involved in the processing of METH reward memory which can be considered for further investigations to manage the relapse associated with drug-related memory.
['Shahveisi|Kaveh|K|', 'Khazaie|Habibolah|H|', 'Farnia|Vahid|V|', 'Khodamoradi|Mehdi|M|']
D000818:Animals D016739:Behavior, Addictive D001522:Behavior, Animal D000697:Central Nervous System Stimulants D058999:Drug-Seeking Behavior D008124:Locomotion D008297:Male D008568:Memory D008694:Methamphetamine D051381:Rats D017208:Rats, Wistar D012008:Recurrence D012201:Reward D000077330:Saline Solution D012892:Sleep Deprivation D012895:Sleep, REM
REM sleep deprivation Retrieval Reconsolidation Methamphetamine Reward memory