Nitrous oxide induced subacute combined degeneration with longitudinally extensive myelopathy with inverted V-sign on spinal MRI: a case report and literature review.
BACKGROUND
Nitrous oxide (N2O), a long-standing anesthetic, is also neurotoxic by interfering with the bioavailability of vitamin B12 if abused. A few case studies have reported the neurological and psychiatric complications of N2O.


CASE PRESENTATION
Here, we reported a patient of N2O induced subacute combined degeneration (SCD) with longitudinally extensive myelopathy with inverted V-sign exhibiting progressive limb paresthesia and unsteady gait.


CONCLUSIONS
This case raises the awareness of an important mechanism of neural toxicity of N2O, and clinical physicians should be well recognized this in the field of substance-related disorders.
['Yuan|Jun Liang|JL|', 'Wang|Shuang Kun|SK|', 'Jiang|Tao|T|', 'Hu|Wen Li|WL|']
D000328:Adult D005260:Female D006801:Humans D008279:Magnetic Resonance Imaging D009609:Nitrous Oxide D013118:Spinal Cord Diseases D052879:Subacute Combined Degeneration D055815:Young Adult
Nitrous oxide Subacute combined degeneration