Pancreas 3D Organoids: Current and Future Aspects as a Research Platform for Personalized Medicine in Pancreatic Cancer.
Pancreatic ductal adenocarcinoma is one of the most aggressive forms of cancer, and the third leading cause of cancer-related mortality in the United States. Although important advances have been made in the last decade, the mortality rate of pancreatic ductal adenocarcinoma has not changed appreciably. This review summarizes a rapidly emerging model of pancreatic cancer research, focusing on 3-dimensional organoids as a powerful tool for several applications, but above all, representing a step toward personalized medicine.
['Moreira|Leticia|L|', 'Bakir|Basil|B|', 'Chatterji|Priya|P|', 'Dantes|Zahra|Z|', 'Reichert|Maximilian|M|', 'Rustgi|Anil K|AK|']
Pancreas 3D Organoids Personalized Medicine Adenocarcinoma 3D, 3-dimensional GEMMs, genetically engineered mouse models PDAC, pancreatic ductal adenocarcinoma PDX, patient-derived tumor xenografts PanIN, pancreatic intraepithelial neoplasia