Bacterial Exopolysaccharide of Shallow Marine Vent Origin as Agent in Counteracting Immune Disorders Induced by Herpes Virus.
Herpes simplex virus type 2 (HSV-2) is responsible of the continuously increasing viral infections in humans. In a previous study we demonstrated that the exopolysaccharide produced by Bacillus licheniformis strain B3-15 (EPS-B3-15), was able to hinder the HSV-2 replication in peripheral blood mononuclear cells (PBMC) and this antiviral activity appear to be related to a significant stimulation of the Th1-cytokines. In this study we analyse the role of EPS-B3-15 on Th2 cytokine production by PBMC infected or not with HSV-2. EPS-B3-15 demonstrate the ability to induce a particular cytokine network with consequent effects on the immune cells during HSV-2 infection.
['Spanò|Antonio|A|', 'Arena|Adriana|A|']
D000998:Antiviral Agents D001407:Bacillus D018258:Herpesvirus 2, Human D006801:Humans D007154:Immune System Diseases D007963:Leukocytes, Mononuclear D008826:Microbial Sensitivity Tests D011135:Polysaccharides, Bacterial D014779:Virus Replication
exopolysaccharide herpes simplex virus antivirals immunomodulators interleukin-4 shallow hydrothermal vents