Oncocytic glioblastoma: a glioblastoma showing oncocytic changes and increased mitochondrial DNA copy number.
Ten cases of glioblastomas showing oncocytic changes are described. The tumors showed mononuclear to multinuclear cells and abundant, granular, eosinophilic cytoplasm. The cytoplasm of these same cells was filled by strongly immunoreactive mitochondria. At ultrastructure, numerous mitochondria, some of which were large, were evidenced in the cytoplasm of neoplastic cells. Finally, 9 of 10 of these cases had a significantly high mitochondrial DNA content compared with control tissue (P < .01). It seems that, for these tumors, the designation of oncocytic glioblastoma is appropriate. To the best of our knowledge, oncocytic changes have not been previously reported in such neoplasms. Oncocytic glioblastomas have to be added to the long list of various tumors that can manifest "unexpected" oncocytic changes in different organs. Albeit failing to show statistical significance (log-rank test, P = .597; Wilcoxon test, P = .233), we observed a trend for longer median survival in oncocytic glioblastomas, when compared with "ordinary" glioblastomas (median survival of 16 versus 8.7 months). Thus, it seems that the definition of neoplasms showing oncocytic changes, currently based on classic morphological parameters (ie, histology, ultrastructure, and immunohistochemistry), can be expanded by including the quantitative assessment of mitochondrial DNA content.
['Marucci|Gianluca|G|', 'Maresca|Alessandra|A|', 'Caporali|Leonardo|L|', 'Farnedi|Anna|A|', 'Betts|Christine Margaret|CM|', 'Morandi|Luca|L|', 'de Biase|Dario|D|', 'Cerasoli|Serenella|S|', 'Foschini|Maria Pia|MP|', 'Bonora|Elena|E|', 'Vidone|Michele|M|', 'Romeo|Giovanni|G|', 'Perli|Elena|E|', 'Giordano|Carla|C|', "d'Amati|Giulia|G|", 'Gasparre|Giuseppe|G|', 'Baruzzi|Agostino|A|', 'Carelli|Valerio|V|', 'Eusebi|Vincenzo|V|']
D000328:Adult D000368:Aged D001932:Brain Neoplasms D056915:DNA Copy Number Variations D015254:DNA Modification Methylases D045643:DNA Repair Enzymes D004272:DNA, Mitochondrial D005260:Female D005909:Glioblastoma D006801:Humans D007521:Isocitrate Dehydrogenase D007558:Italy D053208:Kaplan-Meier Estimate D008297:Male D008875:Middle Aged D008928:Mitochondria D024862:Oxyphil Cells D015996:Survival Rate D025521:Tumor Suppressor Proteins
Glioblastoma Oncocytic features mtDNA