The Fountain of Youth: It's All in Our Veins.
Cardiovascular dysfunction becomes recognized as a risk for dementia. In this issue of Neuron, Park et al. (2018) report the age-related, brain endothelial-specific upregulation of acid sphingomyelinase (ASM), leading to blood-brain barrier malfunction, neurodegeneration, and memory deficits that were mitigated by ASM inhibition in mice.
['Dominguez-Belloso|Amaia|A|', 'Liebner|Stefan|S|']
D000818:Animals D001812:Blood-Brain Barrier D051242:Caveolin 1 D051379:Mice D055495:Neurogenesis D012060:Rejuvenation D013108:Sphingomyelin Phosphodiesterase
dementia acid sphingomyelinase blood-brain barrier caveolae caveolin-1 permeability