Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members.
Anti-apoptotic B cell lymphoma 2 (BCL2) family members (BCL2, MCL1, BCLxL, BCLW, and BFL1) are key players in the regulation of intrinsic apoptosis. Dysregulation of these proteins not only impairs normal development, but also contributes to tumor progression and resistance to various anti-cancer therapies. Therefore, cells maintain strict control over the expression of anti-apoptotic BCL2 family members using multiple mechanisms. Over the past two decades, the importance of post-transcriptional regulation of mRNA in controlling gene expression and its impact on normal homeostasis and disease have begun to be appreciated. In this review, we discuss the RNA binding proteins (RBPs) and microRNAs (miRNAs) that mediate post-transcriptional regulation of the anti-apoptotic BCL2 family members. We describe their roles and impact on alternative splicing, mRNA turnover, and mRNA subcellular localization. We also point out the importance of future studies in characterizing the crosstalk between RBPs and miRNAs in regulating anti-apoptotic BCL2 family member expression and ultimately apoptosis.
['Cui|Jia|J|', 'Placzek|William J|WJ|']
D017398:Alternative Splicing D000818:Animals D017209:Apoptosis D015972:Gene Expression Regulation, Neoplastic D034441:Heterogeneous-Nuclear Ribonucleoproteins D006801:Humans D035683:MicroRNAs D005810:Multigene Family D019253:Proto-Oncogene Proteins c-bcl-2 D012323:RNA Processing, Post-Transcriptional D020871:RNA Stability D034443:RNA Transport D012333:RNA, Messenger D016601:RNA-Binding Proteins
post-transcriptional regulation apoptosis RNA binding proteins microRNA alternative splicing mRNA subcellular localization anti-apoptotic BCL2 subfamily mRNA stability