The effect of concentrated growth factors in the treatment of periodontal intrabony defects.
AIM
To investigate the effect of concentrated growth factors (CGFs) in human intrabony defect treatment.


METHODS
Thirty-one intrabony defects were randomly treated with CGFs + bovine porous bone mineral (BPBM) or BPBM alone. Probing depth, clinical attachment level and hard tissue fill were evaluated at baseline and 1 year post surgery.


RESULTS
No differences in any of the investigated parameters were observed at baseline. At 1 year post therapy, both groups showed significant improvement in clinical parameters (p < 0.001). CGFs + BPBM was more effective than BPBM alone at decreasing probing depth (4.2 ± 1.3 mm vs 3.0 ± 1.6 mm) and clinical attachment level gain (3.7 ± 1.3 mm vs 2.4 ± 1.1 mm; p ≤ 0.05). A favorable increase of hard tissue fill was noted in CGFs + BPBM group compared with BPBM group (p > 0.05). The contents of growth factors in CGFs were statistically higher than those in platelet poor plasma (p < 0.001).


CONCLUSION
Addition of CGFs significantly improved clinical effectiveness of BPBM for intrabony defect treatment.
['Qiao|Jing|J|', 'Duan|Jinyu|J|', 'Zhang|Yong|Y|', 'Chu|Yi|Y|', 'Sun|Changzhou|C|']
concentrated growth factors periodontal intrabony defects bovine porous bone mineral periodontal regeneration