Discovery of novel (1S)-(-)-verbenone derivatives with anti-oxidant and anti-ischemic effects.
A series of novel (1S)-(-)-verbenone derivatives was synthesized bearing a 4-styryl scaffold. The synthesized compounds were tested for their anti-oxidant, anti-excitotoxic, and anti-ischemic activities. These derivatives significantly reduced oxygen-glucose deprivation-induced neuronal injury and N-methyl-D-aspartic acid-evoked excitotoxicity in cortical neurons. Furthermore, compound 3f was identified as a potent anti-ischemic agent in an in vitro ischemic model, potentially due to the inhibition of N-methyl-D-aspartic acid-evoked excitotoxicity and oxidative/nitrosative stress.
['Ju|Chung|C|', 'Song|Sumi|S|', 'Hwang|Sunyoung|S|', 'Kim|Chorong|C|', 'Kim|Minkyoung|M|', 'Gu|Jail|J|', 'Oh|Yu-Kyoung|YK|', 'Lee|Kyeong|K|', 'Kwon|Jinsun|J|', 'Lee|Kiho|K|', 'Kim|Won-Ki|WK|', 'Choi|Yongseok|Y|']
D000818:Animals D000975:Antioxidants D000081008:Bicyclic Monoterpenes D002478:Cells, Cultured D004195:Disease Models, Animal D055808:Drug Discovery D007511:Ischemia D016202:N-Methylaspartate D009474:Neurons D018696:Neuroprotective Agents D018384:Oxidative Stress D013729:Terpenes
Anti-ischemic activity Anti-excitotoxic activity Anti-oxidant activity Cerebral ischemia Verbenone