Neurotrophin Receptors and Perineural Invasion: Analyses in Select Lineage-Unrelated Cutaneous Malignancies With a Propensity for Perineural Invasion.
In this chapter, we parse the literature on neurotrophins that have been implicated in the pathogenesis of perineural invasion (PNI) in select lineage-unrelated malignancies. We also detail evidence linking neurotrophins and their receptors (TrkA, RET, p75NGFR, and NCAM) to the pathogenesis of PNI in desmoplastic melanoma and cutaneous squamous cell carcinoma-both malignancies with an established propensity for PNI. Lastly, the clinical potential of neurotrophins as receptors for targeted therapies is explored.
['Frydenlund|N F|NF|', 'Mahalingam|M|M|']
D000818:Animals D000970:Antineoplastic Agents D002294:Carcinoma, Squamous Cell D015507:Drugs, Investigational D006801:Humans D008545:Melanoma D008959:Models, Neurological D058990:Molecular Targeted Therapy D009361:Neoplasm Invasiveness D009363:Neoplasm Proteins D009414:Nerve Growth Factors D009419:Nerve Tissue Proteins D010525:Peripheral Nerves D011379:Prognosis D017475:Receptors, Nerve Growth Factor D012583:Schwann Cells D015398:Signal Transduction D012878:Skin Neoplasms
Perineural invasion Cutaneous malignancies GDNF–RET axis NGF–TrkA axis