Comparative Genomics of Serial Candida glabrata Isolates and the Rapid Acquisition of Echinocandin Resistance during Therapy.
The opportunistic pathogen Candida glabrata shows a concerning increase in drug resistance. Here, we present the analysis of two serial bloodstream isolates, obtained 12 days apart. Both isolates show pan-azole resistance and echinocandin resistance was acquired during the sampling interval. Genome sequencing identified nine nonsynonymous SNVs between the strains, including a S663P substitution in FKS2 and previously undescribed SNVs in MDE1 and FPR1, offering insight into how C. glabrata acquires drug resistance and adapts to a human host.
['Barber|Amelia E|AE|', 'Weber|Michael|M|', 'Kaerger|Kerstin|K|', 'Linde|Jörg|J|', 'Gölz|Hanna|H|', 'Duerschmied|Daniel|D|', 'Markert|Antonie|A|', 'Guthke|Reinhard|R|', 'Walther|Grit|G|', 'Kurzai|Oliver|O|0000-0002-7277-2646']
D000935:Antifungal Agents D041221:Candida glabrata D002177:Candidiasis D054714:Echinocandins D005656:Fungal Proteins D023281:Genomics D006801:Humans D008826:Microbial Sensitivity Tests
comparative genomics Candida Candida glabrata resistance candidiasis fungus