Elucidation of the Pathogenesis of Autoinflammatory Diseases Using iPS Cells.
Autoinflammatory diseases are a disease entity caused by the dysregulation of innate immune cells. Typical autoinflammatory diseases are monogenic disorders and often very rare. As a result, there is a relative lack of understanding of the pathogenesis, poor diagnosis and little available treatment. Induced pluripotent stem (iPS) cells are a new technology being applied to in vitro disease modeling. These models are especially useful for the analysis of rare and intractable diseases including autoinflammatory diseases. In this review, I will provide a general overview of iPS cell models for autoinflammatory diseases and a brief description of the results obtained from individual reports.
['Saito|Megumu K|MK|0000-0001-8813-3614']
autoinflammatory diseases iPS cells genome editing macrophages somatic mosaicism