New barbiturates and thiobarbiturates as potential enzyme inhibitors.
A series of 27 new barbiturates and thiobarbiturates have been synthesized by a convenient multi-component reaction in overall excellent yields (87-96%). All the synthesized compounds were characterized by 1H, 13C NMR, EIMS and elemental analysis (C, H, N and S). Furthermore, all compounds were screened for in vitro antioxidant (DPPH radical scavenging), lipoxygenase, chymotrypsin, α-glucosidase and anti-urease activities. Out of the series, 23 in DPPH, 14 in lipoxygenase, 2 in chymotrypsin have shown appreciable IC50 values.
['Qureshi|Ashfaq M|AM|', 'Mumtaz|Saira|S|', 'Rauf|Abdul|A|', 'Ashraf|Muhammad|M|', 'Nasar|Rumana|R|', 'Chohan|Zahid H|ZH|']
D000975:Antioxidants D001463:Barbiturates D001713:Biphenyl Compounds D002918:Chymotrypsin D057075:Enzyme Assays D004791:Enzyme Inhibitors D008084:Lipoxygenase D010851:Picrates D013858:Thiobarbiturates D014510:Urease D000520:alpha-Glucosidases
antioxidant (DPPH radical scavenging) lipoxygenase chymotrypsin α-Glucosidase and anti-urease barbituric acid thiobarbituric acid thiosemicarbazone