Immunomodulatory properties of human placental mesenchymal stem/stromal cells.
Mesenchymal stem/stromal cells (MSCs) are isolated from various fetal and adult tissues such as bone marrow, adipose tissue, cord blood and placenta. Placental MSCs (pMSCs), the main focus of this review, are relatively new MSC types that are not as intensively studied compared with bone marrow-derived MSCs (BMMSCs). MSCs modulate the immune functions of important immune cells involved in alloantigen recognition and elimination, including antigen presenting cells (APCs), T cells, B cells and natural killer (NK) cells. Clinical trials, both completed and underway, employ MSCs to treat various human immunological diseases, such as multiple sclerosis (MS) and type 1 diabetes. However, the mechanisms that mediate the immunosuppressive effects of pMSCs are still largely unknown, and the safety of pMSC use in clinical settings needs further confirmation. Here, we review the current knowledge of the immunosuppressive properties of placental MSCs.
['Abumaree|M H|MH|', 'Abomaray|F M|FM|', 'Alshabibi|M A|MA|', 'AlAskar|A S|AS|', 'Kalionis|B|B|']
D002986:Clinical Trials as Topic D005260:Female D006801:Humans D007108:Immune Tolerance D007167:Immunotherapy D008214:Lymphocytes D045164:Mesenchymal Stem Cell Transplantation D059630:Mesenchymal Stem Cells D010920:Placenta D011247:Pregnancy
Mesenchymal stem/stromal cells Placenta APCs T cells B cells Immunosuppression NK cells