Dynamics of liver enzymes in rabbits experimentally infected with Fasciola sp. (Intermediate form from Japan).
Dynamics of serum liver enzymes in rabbits experimentally infected with metacercariae of Fasciola sp. (intermediate form between Fasciola hepatica and F. gigantica) were monitored. Gradual increase of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were observed from 3 weeks post-inoculation (WPI) and peaked at 6 WPI, which corresponded well to the period of migration and development of juvenile fluke in the liver parenchyma and the time when the young adult flukes migrated to the bile duct. However, no significant increase in serum gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) were observed. This could reflect reduced or minimal injury of bile ducts and biliary epithelia as the flukes had reached the adult stage. Alpha- fetoprotein (AFP) and carcinoembryonic antigen (CEA) were not detected in the infected rabbit during the course of the experiment. Serum liver enzymes monitoring might be useful for understanding the host-parasite relationship in fascioliasis.
['Jarujareet|Wipaporn|W|', 'Taira|Kensuke|K|', 'Ooi|Hong Kean|HK|']
D000410:Alanine Transaminase D000469:Alkaline Phosphatase D000818:Animals D001219:Aspartate Aminotransferases D001652:Bile Ducts D002272:Carcinoembryonic Antigen D005209:Fasciola D005211:Fascioliasis D007564:Japan D008099:Liver D010270:Parasite Egg Count D011817:Rabbits D000509:alpha-Fetoproteins D005723:gamma-Glutamyltransferase
liver enzymes rabbit fascioliasis Fasciola sp. intermediate form