Designing and Comparing Performances of Image Processing Pipeline for Enhancement of I-131-metaiodobenzylguanidine Images.
Objective
An image processing pipeline can have more than one image processing technique in sequence, and the output of the first technique becomes input for the next technique and so on. In this study, we have designed and compared the performances of image processing pipelines for enhancement of I-131-metaiodobenzylguanidine (mIBG) images.


Materials and Methods
Five different image processing pipelines (A [Gaussian filter, normalization], B [histogram specification (image 1), Gaussian filter, normalization], C [histogram specification (image 2), Gaussian filter, normalization], D [{histogram specification (image 3), Gaussian filter, and normalization], and E [histogram specification (image 4), Gaussian filter, normalization]) were designed and their performances were evaluated on I-131-mIBG images (n = 122). The image quality was assessed objectively using Perception-based Image Quality Evaluator (PIQE) score and subjectively (on scale 1-4) by two nuclear medicine physician. Sign test was applied to find the statistically significant difference between the image quality obtained using image processing pipelines. We applied test of proportion to compute difference in proportion of image quality score assigned to images obtained using image processing pipelines.


Results
Based on PIQE score, the quality of images obtained using all the five image processing pipelines were significantly better than that of input images (P < 0.001). The highest image quality score (=4) was assigned maximum number of times (n = 90) to the images obtained using image processing pipeline D and was significantly different from that of the second best image processing pipeline E (P = 0.015).


Conclusions
The image processing pipeline D was found to be better for enhancement of I-131-mIBG images.
['Pandey|Anil Kumar|AK|', 'Dhiman|Shweta|S|', 'ArunRaj|Sreedharan Thankarajan|ST|', 'Patel|Chetan|C|', 'Bal|Chandrashekhar|C|', 'Kumar|Rakesh|R|']
image processing pipeline I-131-metaiodobenzylguanidine images image enhancement