Solanerioside A, an unusual 14,15-dinor-cyclophytane glucoside from the leaves of Solanum erianthum.
Solanerioside A (1), the first example of a diterpenoid glucoside featuring a 14,15-dinor-cyclophytane scaffold, together with three known terpene glucosides (2-4) were isolated from the methanol extract of the leaves of Solanum erianthum (Solanaceae). The structure of 1 was mainly characterised on the basis of extensive spectroscopic analyses, especially from the 2D NMR spectra. In addition, the spectroscopic data of (6E, 10E)-5,12-dihydroxy-β-nerolidol 5-O-β-D-glucopyranoside (3) were reported for the first time. However, these compounds did not display obvious inhibition of LPS-induced NO release in RAW264.7 cells and anti-tumour activity against A549, HepG2, Hela and MCF-7 cells in vitro.
['Peng|Shi-Yi|SY|', 'Li|Hang|H|', 'Yang|De-Po|DP|', 'Bai|Bai|B|', 'Zhu|Long-Ping|LP|', 'Liu|Qin|Q|', 'Shen|Juan|J|', 'Zhao|Zhi-Min|ZM|']
D000818:Animals D000972:Antineoplastic Agents, Phytogenic D045744:Cell Line, Tumor D004224:Diterpenes D005960:Glucosides D006801:Humans D008070:Lipopolysaccharides D009682:Magnetic Resonance Spectroscopy D051379:Mice D009569:Nitric Oxide D010936:Plant Extracts D018515:Plant Leaves D000067996:RAW 264.7 Cells D032322:Solanum D021241:Spectrometry, Mass, Electrospray Ionization D013055:Spectrophotometry, Infrared
Solanum erianthum diterpenoid glucoside Solanaceae sesquiterpene glucoside