Kisspeptins, new local modulators of male reproduction: A comparative overview.
Spermatogenesis is a complex process that leads to the production of male gametes within the testis through the coordination of mitotic, meiotic and differentiation events, under a deep control of endocrine, paracrine and autocrine modulators along the Hypothalamus-pituitary-gonad (HPG) axis. The kisspeptin system plays a fundamental role along the HPG axis as it is the main positive modulator upstream of the hypothalamic neurons that secrete the Gonadotropin Releasing Hormone (GnRH), the decapeptide that supports pituitary gonadotropins and the production of gonadal sex steroid. Currently, kisspeptins and their receptor, KISS1R, have a recognized activity in the central control of puberty onset, sex maturation, reproduction and sex-steroid feedback mechanisms in both animal models and human. However, kisspeptin signaling has been widely reported in peripheral tissues, particularly in the testis of mammalian and non-mammalian vertebrates, with functions related to Leydig cells physiology and steroid biosynthesis, spermatogenesis progression and spermatozoa functions, but its mandatory role within the testis is still a matter of discussion. This review provides a summary of the main intratesticular effects of kisspeptin in vertebrates, via a comparative approach. Particular emphasis was devoted to data from the anuran amphibian Pelophylax esculentus, the first animal model in which the direct intratesticular activity of kisspeptin was reported.
['Meccariello|Rosaria|R|', 'Fasano|Silvia|S|', 'Pierantoni|Riccardo|R|']
D000818:Animals D005298:Fertility D012739:Gonadal Steroid Hormones D006801:Humans D059648:Kisspeptins D008297:Male D000074502:Receptors, Kisspeptin-1 D012098:Reproduction D015398:Signal Transduction D013091:Spermatogenesis
Kisspeptins Spermatogenesis Differentiation HPG axis Sex steroids KISS1R Spermatozoa Proliferation