Homoisoflavonoids and the Antioxidant Activity of Ophiopogon japonicus Root.
The root of Ophiopogon japonicus has been used as a traditional Chinese medicine and also a functional food ingredient for a long time in China. In the present study, 17 different homoisoflavonoid compounds were identified in the root extract of O. japonicus by HPLC-DAD and LCMS/MS analyses. The antioxidant activity of the of chloroform/methanol (1:1, v/v), methanol and 70% ethanol extracts, and two major isolated homoisoflavonoid compounds (methylophiopogonanone A and methylophiopogonanone B) from O. japonicus root were investigated by various in-vitro assays. Methylophiopogonanone B showed the highest antioxidant ability according to four antioxidant methods. Among the extracts, the chloroform/methanol extract which contained high amounts of homoisoflavonoids was found to exhibit the strongest antioxidant activity. The results showed that O. japonicus root can be regarded as a potential source of homoisoflavonoids and natural antioxidant.
['Wang|Yancui|Y|', 'Liu|Feng|F|', 'Liang|Zongsuo|Z|', 'Peng|Liang|L|', 'Wang|Bangqing|B|', 'Yu|Jing|J|', 'Su|Yingying|Y|', 'Ma|Cunde|C|']
Homoisoflavonoids Antioxidant activity LCMS/MS analysis Ophiopogon japonicas