Diagnostic performance of diffusion tensor imaging for preo- perative glioma grading.
Background
This study aimed to determine the diagnostic per-formance of fractional anisotropy (FA) and mean diffusivity (MD) values for glioma grading.


Conclusion
The tMD, rMDt/w, and rFAp/w values represent useful indices for the differentiation between LGG and HGG. The combination of these indices can improve diagnostic specificity.


Methods
A total of 42 patients who underwent biopsy or surge-ry and were histologically diagnosed with glioma from September 2019 to December 2020 were enrolled in this retrospective study. Diffusion tensor imaging (DTI) and conventional magnetic resonance imaging (MRI) were performed preoperatively using 3 Tesla MRI in all cases. The FA and MD values were measured in the solid portion of the tumor, the peritumoral area, and the normal white matter. The diagnostic performances of the absolute and relative FA and MD values for glioma grading were analyzed using the receiver operating characteristic (ROC) curve.


Results
The MD value in the solid portion of the tumor (tMD), the MD value of the solid portion of the tumor relative to that in the normal white matter (rMDt/w), and the FA value for the peritumoral region relative to that of the normal white matter (rFAp/w) showed significant differences between the low-grade (LGG) and high-grade glioma (HGG) groups. The combination of these three parameters provided the largest area under the curve value of 89% with sensitivity, specificity, accuracy, negative predictive, and positive predictive values of 72%, 100%, 81%, 62%, and 100%, respectively, for distinguishing between the LGG and HGG groups.
['Duy Hung|N|N|', 'Minh Duc|N|N|', 'Van Anh|N T|NT|', 'Thanh Dung|L|L|', 'He|D V|DV|']
D000293:Adolescent D000328:Adult D016880:Anisotropy D001932:Brain Neoplasms D002648:Child D038524:Diffusion Magnetic Resonance Imaging D056324:Diffusion Tensor Imaging D005260:Female D005910:Glioma D006801:Humans D008297:Male D008875:Middle Aged D060787:Neoplasm Grading D011300:Preoperative Care D012372:ROC Curve D012189:Retrospective Studies D012680:Sensitivity and Specificity D055815:Young Adult
diffusion tensor imaging gliomas magnetic resonance imaging