INfluenza Vaccine Indication During therapy with Immune checkpoint inhibitors: a transversal challenge. The INVIDIa study.
AIM
Considering the unmet need for the counseling of cancer patients treated with immune checkpoint inhibitors (CKI) about influenza vaccination, an explorative study was planned to assess flu vaccine efficacy in this population.


METHODS
INVIDIa was a retrospective, multicenter study, enrolling consecutive advanced cancer outpatients receiving CKI during the influenza season 2016-2017.


RESULTS
Of 300 patients, 79 received flu vaccine. The incidence of influenza syndrome was 24.1% among vaccinated, versus 11.8% of controls; odds ratio: 2.4; 95% CI: 1.23-4.59; p = 0.009. The clinical ineffectiveness of vaccine was more pronounced among elderly: 37.8% among vaccinated patients, versus 6.1% of unvaccinated, odds ratio: 9.28; 95% CI: 2.77-31.14; p < 0.0001.


CONCLUSION
Although influenza vaccine may be clinically ineffective in advanced cancer patients receiving CKI, it seems not to negatively impact the efficacy of anticancer therapy.
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D000911:Antibodies, Monoclonal D061025:Costimulatory and Inhibitory T-Cell Receptors D005260:Female D005500:Follow-Up Studies D006801:Humans D007167:Immunotherapy D015994:Incidence D009980:Influenza A virus D007252:Influenza Vaccines D007251:Influenza, Human D007558:Italy D008297:Male D009369:Neoplasms D012189:Retrospective Studies D014611:Vaccination
influenza vaccine immune checkpoint inhibitors influenza syndrome