Extending the Human Connectome Project across ages: Imaging protocols for the Lifespan Development and Aging projects.
The Human Connectome Projects in Development (HCP-D) and Aging (HCP-A) are two large-scale brain imaging studies that will extend the recently completed HCP Young-Adult (HCP-YA) project to nearly the full lifespan, collecting structural, resting-state fMRI, task-fMRI, diffusion, and perfusion MRI in participants from 5 to 100+ years of age. HCP-D is enrolling 1300+ healthy children, adolescents, and young adults (ages 5-21), and HCP-A is enrolling 1200+ healthy adults (ages 36-100+), with each study collecting longitudinal data in a subset of individuals at particular age ranges. The imaging protocols of the HCP-D and HCP-A studies are very similar, differing primarily in the selection of different task-fMRI paradigms. We strove to harmonize the imaging protocol to the greatest extent feasible with the completed HCP-YA (1200+ participants, aged 22-35), but some imaging-related changes were motivated or necessitated by hardware changes, the need to reduce the total amount of scanning per participant, and/or the additional challenges of working with young and elderly populations. Here, we provide an overview of the common HCP-D/A imaging protocol including data and rationales for protocol decisions and changes relative to HCP-YA. The result will be a large, rich, multi-modal, and freely available set of consistently acquired data for use by the scientific community to investigate and define normative developmental and aging related changes in the healthy human brain.
['Harms|Michael P|MP|', 'Somerville|Leah H|LH|', 'Ances|Beau M|BM|', 'Andersson|Jesper|J|', 'Barch|Deanna M|DM|', 'Bastiani|Matteo|M|', 'Bookheimer|Susan Y|SY|', 'Brown|Timothy B|TB|', 'Buckner|Randy L|RL|', 'Burgess|Gregory C|GC|', 'Coalson|Timothy S|TS|', 'Chappell|Michael A|MA|', 'Dapretto|Mirella|M|', 'Douaud|Gwenaëlle|G|', 'Fischl|Bruce|B|', 'Glasser|Matthew F|MF|', 'Greve|Douglas N|DN|', 'Hodge|Cynthia|C|', 'Jamison|Keith W|KW|', 'Jbabdi|Saad|S|', 'Kandala|Sridhar|S|', 'Li|Xiufeng|X|', 'Mair|Ross W|RW|', 'Mangia|Silvia|S|', 'Marcus|Daniel|D|', 'Mascali|Daniele|D|', 'Moeller|Steen|S|', 'Nichols|Thomas E|TE|', 'Robinson|Emma C|EC|', 'Salat|David H|DH|', 'Smith|Stephen M|SM|', 'Sotiropoulos|Stamatios N|SN|', 'Terpstra|Melissa|M|', 'Thomas|Kathleen M|KM|', 'Tisdall|M Dylan|MD|', 'Ugurbil|Kamil|K|', 'van der Kouwe|Andre|A|', 'Woods|Roger P|RP|', 'Zöllei|Lilla|L|', 'Van Essen|David C|DC|', 'Yacoub|Essa|E|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D000375:Aging D001921:Brain D002648:Child D002675:Child, Preschool D063132:Connectome D005260:Female D006801:Humans D008136:Longevity D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D055815:Young Adult
Connectomics Aging Lifespan Development Resting-state Diffusion Perfusion Functional connectivity Task