ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates with poor prognosis in non-small cell lung cancer.
Immunoglobulin-like transcript (ILT) 4 is critical for the inhibitory function of certain immune cells. We previously demonstrated that ILT4 is over-expressed in human non-small cell lung cancer (NSCLC) cells and is involved in tumour evasion via an unknown mechanism. In this report, we demonstrate that ILT4 increases the expression of the co-inhibitory molecule B7-H3 through PI3K/AKT/mTOR signalling. In primary human NSCLC tissues, a significant positive relationship is observed between ILT4 and B7-H3 expression. ILT4/B7-H3 co-expression is significantly associated with a reduction in T infiltrating lymphoid cells and lower overall survival. In summary, ILT4 increases B7-H3 expression and ILT4/B7-H3 co-expression may be involved in NSCLC progression.
['Zhang|Pei|P|', 'Yu|Shuwen|S|', 'Li|Hongyu|H|', 'Liu|Chuanyong|C|', 'Li|Juan|J|', 'Lin|Wenli|W|', 'Gao|Aiqin|A|', 'Wang|Linlin|L|', 'Gao|Wei|W|', 'Sun|Yuping|Y|']
D060887:B7 Antigens D015153:Blotting, Western D002289:Carcinoma, Non-Small-Cell Lung D045744:Cell Line, Tumor D005260:Female D020869:Gene Expression Profiling D015972:Gene Expression Regulation, Neoplastic D006801:Humans D007150:Immunohistochemistry D053208:Kaplan-Meier Estimate D008175:Lung Neoplasms D008297:Male D008562:Membrane Glycoproteins D008875:Middle Aged D019869:Phosphatidylinositol 3-Kinases D011379:Prognosis D051057:Proto-Oncogene Proteins c-akt D034622:RNA Interference D011971:Receptors, Immunologic D020133:Reverse Transcriptase Polymerase Chain Reaction D015398:Signal Transduction D058570:TOR Serine-Threonine Kinases
ILT4 B7-H3 PI3K/AKT/mTOR signalling Non-small cell lung cancer