The significance of the oxidative stress markers in the one-year prognosis of patients with acute ischemic stroke: a case-control study.
BACKGROUND
Stroke is a major cause of mortality and morbidity. Also, free radicals and oxidative stress are deleterious factor in the stroke progression. We aimed to evaluate the association between oxidative stress markers and odds of having risk factor for stroke or developing stroke.


METHODS
The present case-control study was conducted on 556 participants in Imam-Reza hospital, Tabriz, Iran. Subjects were divided into three group, including individuals with acute ischemic stroke, those who were at risk of stroke, and healthy controls. All enrolled participants except for controls underwent neurological examinations and brain magnetic resonance imaging (MRI). Stroke-related disability and stroke severity were evaluated by modified Rankin Scale (mRS) and National Institutes of Health Stroke Scale (NIHSS), respectively. Serum malondialdehyde (MDA) level and total antioxidant capacity (TAC) were measured within 48 h of the initiation of stroke. One-way ANOVA and Chi-square tests were used for comparing characteristics between groups. Multivariable logistic regression was implemented for odds of stroke based on MDA and TAC quartiles. Also, Spearman's correlation was utilized.


RESULTS
Serum MDA, systolic and diastolic blood pressure, cholesterol, and triglyceride were significantly higher in the stroke group than controls. High levels of MDA were associated with increased development of stroke (P-value < 0.001), however TAC and MDA were not associated with having risk factors for stroke (P-value = 1.00 and 0.27, respectively). Also, TAC level was negatively associated with baseline (ρ = - 0.28; P-value = 0.04) and follow-up (ρ = - 0.31; P-value = 0.03) NIHSS scores. Moreover, MDA was correlated with mRS score at follow-up (ρ = - 0.26; P-value = 0.04).


CONCLUSIONS
The balance between antioxidants and oxidants markers might reveal a new approach in this context. Further studies are warranted to identify the source of oxidative stress as well as cessation of the production of oxygen radicals in stroke.
['Shaafi|Sheida|S|', 'Hadisi|Fina|F|', 'Mahmoudinezhad|Mahsa|M|', 'Razmi|Hamidreza|H|', 'Nejadghaderi|Seyed Aria|SA|', 'Khalili|Mohammad|M|']
D000975:Antioxidants D015415:Biomarkers D016022:Case-Control Studies D006801:Humans D000083242:Ischemic Stroke D018384:Oxidative Stress D011379:Prognosis D012307:Risk Factors
Stroke Case-control study Modified Rankin scale National Institutes of Health stroke scale Malondialdehyde Total antioxidant capacity