Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin.
Cancer is one of the leading causes of death worldwide. The agents capable of causing damage to genetic material are known as genotoxins and, according to their mode of action, are classified into mutagens, carcinogens, or teratogens. Genotoxins are also involved in the pathogenesis of several chronic degenerative diseases, including hepatic, neurodegenerative, and cardiovascular disorders; diabetes; arthritis; cancer; chronic inflammation; and ageing. In recent decades, researchers have found novel bioactive phytocompounds able to counteract the effects of physical and chemical mutagens. Several studies have shown the antigenotoxic potential of different fruits and plants (Part 1). In this review (Part 2), we present a research overview conducted on some plants and vegetables (spirulina, broccoli, chamomile, cocoa, ginger, laurel, marigold, roselle, and rosemary), which are frequently consumed by humans. In addition, an analysis of some phytochemicals extracted from those vegetables and the analysis of a resin (propolis),whose antigenotoxic power has been demonstrated in various tests, including the Ames assay, sister chromatid exchange, chromosomal aberrations, micronucleus, and comet assay, was also performed.
['López-Romero|David|D|', 'Izquierdo-Vega|Jeannett A|JA|', 'Morales-González|José Antonio|JA|0000-0002-5980-0980', 'Madrigal-Bujaidar|Eduardo|E|', 'Chamorro-Cevallos|Germán|G|0000-0002-8935-9831', 'Sánchez-Gutiérrez|Manuel|M|', 'Betanzos-Cabrera|Gabriel|G|0000-0003-2027-6904', 'Alvarez-Gonzalez|Isela|I|', 'Morales-González|Ángel|Á|0000-0003-2920-8078', 'Madrigal-Santillán|Eduardo|E|0000-0003-2264-4598']
D000818:Animals D016587:Antimutagenic Agents D001688:Biological Products D002460:Cell Line D020552:Comet Assay D004249:DNA Damage D006801:Humans D051379:Mice D064209:Phytochemicals D028321:Plant Preparations D011429:Propolis D053545:Spirulina D014675:Vegetables
antigenotoxic plants vegetables cancer micronucleus comet assay propolis