Efficiency of Cell Therapy in Liver Cirrhosis.
We studied safety and clinical efficacy of transplantation of autologous bone marrow cell in complex therapy of 158 patients with chronic hepatitis and cirrhosis of the liver. The efficiency of cell therapy was assessed in 12 months after single injection of the cells. The positive response (alleviation of liver cirrhosis or stabilization of the pathological process) was observed in 70% cases. The efficacy of therapy correlated with the severity and etiology of the disease and was maximum in patients with Child-Pugh class A (in 82.5% cases) and class B liver cirrhosis (in 79% cases); in patients with class C liver cirrhosis, the positive response was achieved in 42.5% cases. In 39 patients, ultrasonic examination performed in 3 years after transplantation revealed no focal lesions or ectopic ossification foci.
['Shevela|E Ya|EY|', 'Starostina|N M|NM|', "Pal'tsev|A I|AI|", 'Shipunov|M V|MV|', 'Zheltova|O I|OI|', 'Meledina|I V|IV|', 'Khvan|L A|LA|', 'Leplina|O Yu|OY|', 'Ostanin|A A|AA|', 'Chernykh|E R|ER|', 'Kozlov|V A|VA|']
D000293:Adolescent D000328:Adult D000368:Aged D001854:Bone Marrow Cells D016026:Bone Marrow Transplantation D064987:Cell- and Tissue-Based Therapy D005260:Female D006521:Hepatitis, Chronic D006801:Humans D008099:Liver D008103:Liver Cirrhosis D008297:Male D008875:Middle Aged D014182:Transplantation, Autologous D016896:Treatment Outcome D055815:Young Adult
transplantation bone marrow cirrhosis of the liver stem cells