Effects of different chemical groups on behaviors of bladder cancer cells.
Chemical groups of microenvironment play an important role in the adhesion, proliferation, and apoptosis of tumor cells. The different chemical groups (CH3 , OH, COOH) were grafted on the surfaces with the same density by self-assembly monolayer (SAM) technique to introduce the influence of different microenvironments of the human bladder cancer (5637) cells. The results indicated that the 5637 cells on COOH surface exhibited the lowest proliferation rate and the highest apoptosis rate on the first and fifth day because of negative charge and polarity of the COOH group, which might help optimize biomedicine materials and find new methods to treat bladder cancer.
['Cao|Hui|H|0000-0003-2137-643X', 'Huang|Denggao|D|', 'Guo|Lifang|L|', 'Gao|Yuanhui|Y|', 'Zheng|Linlin|L|', 'Xiao|Jingchuan|J|', 'Zhang|Shufang|S|', 'Yu|Xiaolong|X|']
D017209:Apoptosis D001672:Biocompatible Materials D002448:Cell Adhesion D045744:Cell Line, Tumor D049109:Cell Proliferation D006801:Humans D059016:Tumor Microenvironment D001749:Urinary Bladder Neoplasms
chemical groups proliferation apoptosis 5637 cells cell adhesion