SLE-key(®) rule-out serologic test for excluding the diagnosis of systemic lupus erythematosus: Developing the ImmunArray iCHIP(®).
We describe here the development, verification and validation of the SLE-key(®) rule-out test for a definitive rule-out of a diagnosis of systemic lupus erythematosus (SLE). The test uses the proprietary iCHIP(®) micro-array technology platform (Fattal et al., 2010) to identify discriminating patterns of circulating autoantibodies among SLE patients compared with self-declared healthy individuals. Given the challenges associated with the diagnosis of SLE and the healthcare costs of delayed diagnosis and misdiagnosis, a definitive rule-out test can provide significant clinical benefits to patients and potentially major cost savings to healthcare systems.
['Putterman|Chaim|C|', 'Wu|Alan|A|', 'Reiner-Benaim|Anat|A|', 'Batty|D Scott|DS|', 'Sanz|Ignacio|I|', 'Oates|Jim|J|', 'Jakobi|Keren|K|', 'Petri|Michelle|M|', 'Safer|Pennina|P|', 'Gerwien|Robert|R|', 'Sorek|Rachel|R|', 'Blumenstein|Yakov|Y|', 'Cohen|Irun R|IR|']
D000293:Adolescent D000328:Adult D001323:Autoantibodies D005260:Female D006801:Humans D007118:Immunoassay D008180:Lupus Erythematosus, Systemic D008875:Middle Aged D040081:Protein Array Analysis D012698:Serologic Tests D055815:Young Adult
Diagnosis Systemic lupus erythematosus ICHIP Autoantibodies Microarray Multivariate classifier