Perspectives on antigen presenting cells in zebrafish.
Antigen presentation is a critical step in the activation of naïve T lymphocytes. In mammals, dendritic cells (DCs), macrophages, and B lymphocytes can all function as antigen presenting cells (APCs). Although APCs have been identified in zebrafish, it is unclear if they fulfill similar roles in the initiation of adaptive immunity. Here we review the characterization of zebrafish macrophages, DCs, and B cells and evidence of their function as true APCs. Finally, we discuss the conservation of APC activity in vertebrates and the use of zebrafish to provide a new perspective on the evolution of these functions.
['Lewis|Kanako L|KL|', 'Del Cid|Natasha|N|', 'Traver|David|D|']
D000818:Animals D000938:Antigen-Presenting Cells D001402:B-Lymphocytes D003713:Dendritic Cells D006649:Histocompatibility Antigens D008264:Macrophages D014714:Vertebrates D015027:Zebrafish
Zebrafish Dendritic cells Macrophages B lymphocytes Antigen-presenting cells