Investigation of a novel variable dosing protocol for radioiodine treatment of feline hyperthyroidism.
BACKGROUND
Radioiodine is the treatment of choice for hyperthyroidism in cats. The ideal method of dose determination of radioiodine remains controversial.


OBJECTIVE
To compare a method of radioiodine dose determination that utilized thyroid scintigraphy with a standard fixed dose for treatment of hyperthyroidism.


ANIMALS
Fifty-seven and 23 client-owned hyperthyroid cats in the variable and fixed dose groups, respectively.


METHODS
Cats with a percent dose uptake using 99m Tc-pertechnetate uptake on thyroid scintigraphy <5%, 5%-10%, and >10% were to receive 3, 3.5, or 4.5 millicuries (mCi) of radioiodine, respectively, administered SC. Radioiodine dose was adjusted according to thyroid gland size as determined by the thyroid:salivary size ratio and categorized as <5:1, 5-10:1, and >10:1. If the thyroid size fell into a higher dosing category than the percent dose uptake, the dose was increased accordingly. Cats in the fixed dose group received 4.5 mCi. Six months after treatment, cats were determined to be euthyroid, hypothyroid, or hyperthyroid based on serum thyroxine and thyroid stimulating hormone concentrations.


RESULTS
No difference in outcome was found between the variable and fixed dose treatment groups. Euthyroidism, hypothyroidism, and persistent hyperthyroidism developed in 61, 30, and 9% of cats in the fixed dose group compared to 58, 26, and 16%, respectively, in the variable dose group.


CONCLUSIONS
A variable dosing method of radioiodine based on percent dose uptake primarily and thyroid gland size secondarily did not improve outcome compared to a standard fixed dose method.
['Morré|Wendy A|WA|https://orcid.org/0000-0002-6541-3661', 'Panciera|David L|DL|', 'Daniel|Gregory B|GB|', 'Monroe|William E|WE|', 'Werre|Stephen|S|']
D000818:Animals D002371:Cat Diseases D002415:Cats D054796:Drug Dosage Calculations D005260:Female D006980:Hyperthyroidism D007457:Iodine Radioisotopes D008297:Male D016896:Treatment Outcome
radioiodine feline hyperthyroid scintigraphy