A new childhood asthma phenotype: obese with early menarche.
Three concomitant phenomena occur in the later years of childhood: increases in the incidence of asthma, obesity and early menarche. This article is an overview of the current epidemiologic, basic, genetic and epigenetic evidence about this relationship. As a consequence we propose that obese girls who have an early menarche (≤ 11 years of age) constitute a new asthma phenotype in childhood. Future studies need to be carried out in order to find the best control and treatment of this new asthma phenotype.
['Castro-Rodriguez|Jose A|JA|']
D000367:Age Factors D001249:Asthma D005260:Female D014943:Global Health D006801:Humans D015994:Incidence D008572:Menarche D009765:Obesity D010641:Phenotype D012307:Risk Factors
Childhood Asthma phenotype Obesity Early menarche Epidemiology Genetics