Repurposing Riociguat for Treatment of Refractory Angina Resulting From Coronary Spasm.
Coronary spasm is a frequent cause of angina despite unobstructed coronary arteries, and symptom control with recommended drugs is limited. We report the case of a 77-year-old woman who had refractory angina despite conventional antianginal treatment. Repurposing riociguat, a soluble guanylate cyclase stimulator, resulted in improvement of symptoms and prevention of spasm. (Level of Difficulty: Intermediate.).
['Martínez Pereyra|Valeria|V|', 'Seitz|Andreas|A|', 'Hubert|Astrid|A|', 'Beck|Sascha|S|', 'Hofmann|Ute|U|', 'Schwab|Matthias|M|', 'Bekeredjian|Raffi|R|', 'Sechtem|Udo|U|', 'Ong|Peter|P|']
riociguat soluble guanylate cyclase ACh, acetylcholine ECG, electrocardiogram LCx, left circumflex artery acetylcholine testing coronary artery spasm drug repurposing individual treatment trial microvascular dysfunction sGC, soluble guanylate cyclase