Simultaneously increased expression of microRNA-155 and suppressor of cytokine signaling 1 (SOCS1) gene in the peripheral blood mononuclear cells of patients with primary Sjögren's syndrome.
AIM
The microRNA-155 (miR-155) is regarded as a central modulator of T-cell responses and could be a potential therapeutic target for certain inflammatory diseases. In our present study we analyzed the expression rate of miR-155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 (SOCS1) in primary Sjögren's syndrome (pSS).


METHOD
We enrolled 23 pSS patients and 10 healthy individuals in the study. The expression of miR-155 and SOCS1 gene were measured by real-time polymerase chain reaction.


RESULTS
We observed the over-expression of miR-155 in the peripheral mononuclear cells of patients with pSS. Surprisingly, SOCS1 gene was also over-expressed in pSS patients.


CONCLUSION
This unanticipated phenomenon might be a laboratory characteristic of Sjögren's syndrome, and presumably a consequence of the noteworthy difference in the pSS immune system reacting with Epstein-Barr virus.
['Chen|Ji-Qing|JQ|', 'Zilahi|Erika|E|', 'Papp|Gábor|G|', 'Sipka|Sándor|S|', 'Zeher|Margit|M|http://orcid.org/0000-0002-4698-3351']
D000368:Aged D016022:Case-Control Studies D005260:Female D005819:Genetic Markers D006801:Humans D007963:Leukocytes, Mononuclear D008297:Male D035683:MicroRNAs D008875:Middle Aged D060888:Real-Time Polymerase Chain Reaction D012859:Sjogren's Syndrome D000071222:Suppressor of Cytokine Signaling 1 Protein D015854:Up-Regulation
suppressor of cytokine signaling 1 (SOCS1) microRNA-155 (miR-155) primary Sjögren's syndrome (pSS)