The role of Clofarabine in the treatment of adults with acute myeloid leukemia.
The therapeutic scenario available for adult patients with acute myeloid leukemia (AML) has shown only partial progresses over the last few years. This is especially true for refractory and relapsed AML whose outcome is still extremely disappointing. In this context Clofarabine has offered new promising perspectives within first and second line protocols. This review will firstly describe the initial development in monotherapy, considering then the different potential combination strategies which include both polichemotherapeutic regimens and less conventional approaches with new generation drugs. The potential use of Clofarabine as induction treatment for patients candidate to stem cell transplantation and within conditioning regimens will be finally evaluated.
['Fozza|Claudio|C|']
D000227:Adenine Nucleotides D000328:Adult D000971:Antineoplastic Combined Chemotherapy Protocols D001087:Arabinonucleosides D002986:Clinical Trials as Topic D000077866:Clofarabine D003561:Cytarabine D018380:Hematopoietic Stem Cell Transplantation D006801:Humans D015470:Leukemia, Myeloid, Acute D012074:Remission Induction D016896:Treatment Outcome
Clofarabine Adults Acute myeloid leukemia (AML)