The effect of Allium cepa extract on the chitosan/PLGA scaffolds bioactivity.
Allium cepa extracts (AC) allow the fabrication of a biomaterial that, together with chitosan and PLGA, could be osteoconductive and promote a better and faster regeneration of bone tissue, with biocompatibility and biomineralization properties. In this work, scaffolds were developed by the thermally induced phase separation (TIPS) technique. An in vitro bioactivity analysis was performed using simulated body fluid (SBF). Scanning electron microscopy (SEM), energy dispersion spectroscopy, and infrared spectroscopy were used for the scaffolds characterization. The results showed a structure with a pore size distribution between 50 and 100 μm, which allowed the uniform formation of biological apatite crystals on the surface of the scaffolds. The chitosan/policaprolactone/Allium cepa scaffold (ChPAC) showed the most promising results with a ratio of P/Ca between 1.6 and 1.7, a value very close to that of hydroxyapatite.
['Monárrez-Cordero|Blanca Elizabeth|BE|', 'Rodríguez-González|Claudia Alejandra|CA|', 'Valencia-Gómez|Laura Elizabeth|LE|', 'Hernández-Paz|Juan Francisco|JF|', 'Martel-Estrada|Santos Adriana|SA|', 'Camacho-Montes|Héctor|H|', 'Olivas-Armendáriz|Imelda|I|https://orcid.org/0000-0003-2233-0310']
D001861:Bone Regeneration D048271:Chitosan D017886:Durapatite D008855:Microscopy, Electron, Scanning D019697:Onions D010936:Plant Extracts D016062:Porosity D023822:Tissue Engineering D054457:Tissue Scaffolds
Allium cepa chitosan PLGA scaffold bioactivity