A Retrospective Cohort Study of Risk Factors for Surgical Site Infection Following Liver Transplantation.
BACKGROUND
Surgical site infection is an important complication in the postoperative period among liver transplant recipients. However, little is known about the risk factors in this patient group. Therefore, the objective of this study was to analyze the incidence and risk factors for surgical site infections among adult liver transplant recipients.


METHODS
Medical records of adult liver transplant recipients from January 1, 2009, to December 31, 2015, were analyzed in this retrospective cohort study.


RESULTS
We enrolled 156 recipients' medical records. Forty-two (26.9%) cases of surgical site infections were identified. The main isolated microorganisms were methicillin-resistant Staphylococcus species, extended spectrum β-lactamase-producing Klebsiella species, carbapenem-resistant Pseudomonas aeruginosa, carbapenem-resistant Acinetobacter baumannii, and vancomycin-susceptible Enterococcus faecalis. We found that long operative times (≥487 minutes) and differences in body mass index between donor and recipient (≥1.3 kg/m2) increased the risk for surgical site infections by approximately 5 times (odds ratio [OR], 5.5; 95% confidence interval [CI], 2.5-11.8), and capillary glycemia ≥175 mg/dL in the first 96 postoperative hours increased the risk by approximately 3 times (OR, 2.97; 95% CI, 1.43-6.17).


CONCLUSIONS
There was a high incidence of surgical site infections among the studied population and that some risk factors identified differ from those reported in the scientific literature.
['Oliveira|Ramon Antônio|RA|0000-0001-9668-7051', 'Mancero|Jorge Marcelo Padilla|JMP|', 'Faria|Dalila Fernanda|DF|', 'Poveda|Vanessa de Brito|VB|']
D000151:Acinetobacter Infections D040981:Acinetobacter baumannii D001938:Brazil D015331:Cohort Studies D005260:Female D006801:Humans D015994:Incidence D016031:Liver Transplantation D008297:Male D008499:Medical Records D055624:Methicillin-Resistant Staphylococcus aureus D008875:Middle Aged D012189:Retrospective Studies D012307:Risk Factors D013203:Staphylococcal Infections D013530:Surgical Wound Infection
health-care-associated infections hepatic transplantation immunocompromised host prevention and control surgical wound infection