The skin microbiome: Associations between altered microbial communities and disease.
A single square centimetre of the human skin can contain up to one billion microorganisms. These diverse communities of bacteria, fungi, mites and viruses can provide protection against disease, but can also exacerbate skin lesions, promote disease and delay wound healing. This review addresses the current knowledge surrounding the healthy skin microbiome and examines how different alterations to the skin microbial communities can contribute to disease. Current methodologies are considered, changes in microbial diversity and colonisation by specific microorganisms are discussed in the context of atopic dermatitis, psoriasis, acne vulgaris and chronic wounds. The recent impact of modern Westernised lifestyles on the human skin microbiome is also examined, as well as the potential benefits and pitfalls of novel therapeutic strategies. Further analysis of the human skin microbiome, and its interactions with the host immune system and other commensal microorganisms, will undoubtedly elucidate molecular mechanisms for disease and reveal gateways for novel therapeutic treatment strategies.
['Weyrich|Laura S|LS|', 'Dixit|Shreya|S|', 'Farrer|Andrew G|AG|', 'Cooper|Alan J|AJ|', 'Cooper|Alan J|AJ|']
D000152:Acne Vulgaris D002908:Chronic Disease D003876:Dermatitis, Atopic D006801:Humans D064307:Microbiota D011565:Psoriasis D012867:Skin D012883:Skin Ulcer D014945:Wound Healing
skin microbiome bacteria atopic dermatitis psoriasis acne chronic wound dermatology