Ileocolic Intussusception as the Presenting Symptom of Primary Enteric Varicella-Zoster Virus Infection in a 7-Month-Old Infant.
Ileocolic intussusception is the invagination of ileum into the colon. In a subset of patients, the disease is caused by mesenteric lymphadenopathy in response to (viral) infection. We present a case of an ileocolic intussusception necessitating surgery in a 7-month-old immunocompetent infant with concurrent primary wild-type varicella-zoster virus (VZV) infection, in whom chickenpox rash developed 2 days after surgery. Detailed in situ analyses of resected intestine for specific cell type markers and VZV RNA demonstrated VZV-infected lymphocytes and neurons in the gut wall and in ganglion cells of the myenteric plexus.
['Windster|Jonathan D|JD|', 'Ouwendijk|Werner J D|WJD|', 'Sloots|Cornelius E J|CEJ|', 'Verjans|Georges M G M|GMGM|', 'Verdijk|Robert M|RM|']
D014645:Herpesvirus 3, Human D006801:Humans D007077:Ileal Diseases D007223:Infant D007410:Intestinal Diseases D007422:Intestines D007443:Intussusception D008214:Lymphocytes D008297:Male D009197:Myenteric Plexus D009474:Neurons D000073618:Varicella Zoster Virus Infection
Intussusception varicella-zoster virus chickenpox lymphocyte ganglion enteric nervous system