Vitamin D and type 2 diabetes mellitus (D2).
Based on increasing evidence from animal and human studies, vitamin D deficiency is now regarded as a potential risk factor for Type 2 diabetes mellitus (T2DM). Vitamin D is involved in the pathogenesis of pancreatic β-cell dysfunction, insulin resistance, and systemic inflammation, conditions that contribute to the development of T2DM. Vitamin D can affect the progress of this disease directly through the activation of its own receptor, and indirectly via the regulation of calcium homeostasis. Observational studies have revealed the association between vitamin D deficiency and incident T2DM. More double-blind randomized control studies that investigate the effects of vitamin D supplementation on insulin sensitivity, insulin secretion, and the occurrence of T2DM are needed.
['Xuan|Yan|Y|', 'Zhao|Hong-yan|HY|', 'Liu|Jian-Min|JM|']
D000818:Animals D002118:Calcium D003924:Diabetes Mellitus, Type 2 D006706:Homeostasis D006801:Humans D050417:Insulin-Secreting Cells D018167:Receptors, Calcitriol D014807:Vitamin D D014808:Vitamin D Deficiency D014815:Vitamins
vitamin D Type 2 diabetes mellitus insulin resistance 胰岛素抵抗，2型糖尿病，维生素 D