Functional brain abnormalities in major depressive disorder using the Hilbert-Huang transform.
Major depressive disorder is a common disease worldwide, which is characterized by significant and persistent depression. Non-invasive accessory diagnosis of depression can be performed by resting-state functional magnetic resonance imaging (rs-fMRI). However, the fMRI signal may not satisfy linearity and stationarity. The Hilbert-Huang transform (HHT) is an adaptive time-frequency localization analysis method suitable for nonlinear and non-stationary signals. The objective of this study was to apply the HHT to rs-fMRI to find the abnormal brain areas of patients with depression. A total of 35 patients with depression and 37 healthy controls were subjected to rs-fMRI. The HHT was performed to extract the Hilbert-weighted mean frequency of the rs-fMRI signals, and multivariate receiver operating characteristic analysis was applied to find the abnormal brain regions with high sensitivity and specificity. We observed differences in Hilbert-weighted mean frequency between the patients and healthy controls mainly in the right hippocampus, right parahippocampal gyrus, left amygdala, and left and right caudate nucleus. Subsequently, the above-mentioned regions were included in the results obtained from the compared region homogeneity and the fractional amplitude of low frequency fluctuation method. We found brain regions with differences in the Hilbert-weighted mean frequency, and examined their sensitivity and specificity, which suggested a potential neuroimaging biomarker to distinguish between patients with depression and healthy controls. We further clarified the pathophysiological abnormality of these regions for the population with major depressive disorder.
['Yu|Haibin|H|', 'Li|Feng|F|', 'Wu|Tong|T|', 'Li|Rui|R|', 'Yao|Li|L|', 'Wang|Chuanyue|C|', 'Wu|Xia|X|']
D000293:Adolescent D000328:Adult D001921:Brain D001931:Brain Mapping D003865:Depressive Disorder, Major D005260:Female D006801:Humans D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D015999:Multivariate Analysis D012372:ROC Curve D012146:Rest D055815:Young Adult
Depression Hilbert-Huang transform Resting-state functional magnetic resonance imaging Hilbert-weighted mean frequency Multivariate receiver operating characteristic analysis