Survival effect of laparoscopic para-aortic staging in locally advanced cervical cancer: a retrospective cohort analysis.
OBJECTIVE
This study compares two methods of evaluating para-aortic node involvement in locally advanced cervical cancer (LACC) in order to define external radiotherapy treatment fields: laparoscopic surgical para-aortic lymphadenectomy or PET-CT imaging.


POPULATION
We selected 187 patients with LACC who had been treated by chemoradiation therapy in two comprehensive cancer centres from January 2001 to December 2013. A total of 98 underwent para-aortic evaluation by PET-CT (Centre 1) and 89 received surgical laparoscopic excision (Centre 2).


METHODS
All patients with LACC were retrospectively collected in each centre. OS and DFS were calculated using the Kaplan-Meier's method and survival curves were compared using log-rank test.


MAIN OUTCOME MEASURES
Outcomes were the comparison of patients' disease-free (DFS) and overall survival (OS) between the two centres.


RESULTS
Patients had a significantly better disease-free survival in cohort 1 than in cohort 2, at 2 years [80.9% (71.7-87.5) versus 57.1% (46.1-67.3)] and at 5 years [70.5% (58.8-79.9) versus 49.2% (38.2-60.4)] (P = 0.009). These results are confirmed by multivariate analysis model [hazard ratio (HR) 1.93; 95% CI 1.03-3.61; P = 0.04]. The overall survival was also better in cohort 1, both at 2 and 5 years [93.5% (86.5-97.0) versus 78.5% (68.5-86.0) and 85.1% (73.2-92.2) versus 63.8% (51.9-74.2), respectively; P = 0.006]. The multivariate analysis model found concordant results with an increased relative risk of death for patients treated in cohort 2 (HR 2.55; 95% CI 1.09-5.99; P = 0.01).


CONCLUSION
In this retrospective cohort analysis, para-aortic surgical staging in LACC is more deleterious for patients than is radiological staging in terms of OS and DFS.


TWEETABLE ABSTRACT
Para-aortic surgical staging in LACC is more deleterious for patients than clinical staging.
['Pomel|C|C|', 'Martinez|A|A|', 'Bourgin|C|C|', 'Beguinot|M|M|', 'Benoit|C|C|', 'Naik|R|R|', 'Dauplat|J|J|', 'Lebouedec|G|G|', 'Ferron|G|G|']
D000328:Adult D000368:Aged D059248:Chemoradiotherapy D015331:Cohort Studies D005260:Female D005602:France D006801:Humans D010535:Laparoscopy D008197:Lymph Node Excision D008198:Lymph Nodes D008207:Lymphatic Metastasis D008875:Middle Aged D009367:Neoplasm Staging D000072078:Positron Emission Tomography Computed Tomography D012189:Retrospective Studies D016019:Survival Analysis D002583:Uterine Cervical Neoplasms
laparoscopic para-aortic staging Cervical cancer external field radiotherapy imaging para-aortic staging