VKORC1 -1639 G>A Polymorphism in Romanian Patients With Deep Vein Thrombosis.
AIM
The purpose of the research was to study the influence of several genetic factors, especially the -1693 G>A polymorphism of the VKORC1 gene, on the risk of acute unprovoked lower extremity deep vein thrombosis (DVT).


MATERIALS AND METHODS
The study included 127 patients (median age 63 [53.2; 72] years; 61 [48%] women and 66 [52%] men) who were diagnosed with acute lower extremity DVT and 114 controls (median age 62 [53; 73] years; 64 [56.1%] women and 50 [43.9%] men) without DVT. We recorded data regarding the history of DVT and the presence of varicose veins. We determined the genotypes for factor V Leiden (FVL) mutation, prothrombin G20210A mutation, VKORC1 -1639 G>A mutation, and PAI-1 -675 4G/5G polymorphism.


RESULTS AND CONCLUSION
Varicose veins were found in 67 (52.8%) patients and 29 (25.4%) controls (P < .001). FVL was present in 29 (22.8%) patients and 10 (8.8%) controls (P = .005). The VKORC1 (-1693 G>A) GG genotype was found in 42 (33.1%) patients and 41 (36%) controls, the GA genotype in 71 (55.9%) patients and 47 (41.2%) controls, and AA genotype in 14 (11%) patients and 26 (22.8%) controls (P = .020). Multivariate analysis showed that the presence of varicose veins, FVL, and VKORC1 -1639 G>A was independently associated with the risk of DVT. The VKORC1 (-1693 G>A) AA genotype was associated with fewer cases of DVT (odds ratio = 0.435; 95% confidence interval 0.205-0.991; P = .031).
['Vesa|Ştefan Cristian|ŞC|', 'Trifa|Adrian Pavel|AP|', 'Crişan|Sorin|S|', 'Buzoianu|Anca Dana|AD|']
D000368:Aged D005260:Female D006801:Humans D008875:Middle Aged D011110:Polymorphism, Genetic D012189:Retrospective Studies D012307:Risk Factors D012383:Romania D019851:Thrombophilia D020246:Venous Thrombosis D064417:Vitamin K Epoxide Reductases
clinical thrombophilia deep venous thrombosis gene polymorphisms thrombophilia