Obesity as a risk factor in cancer: A national consensus of the Spanish Society for the Study of Obesity and the Spanish Society of Medical Oncology.
In the last few years, many prospective studies have demonstrated a clear association between obesity and cancers of the colon and rectum, breast in post-menopausal women, endometrium, kidney, oesophagus and pancreas. Obesity is also associated with a high risk of recurrence and cancer-related death. The pathophysiology of obesity involves various changes that may be implicated in the relationship between obesity and cancer, such as excess inflammatory cytokines and chronic inflammation, hyperinsulinaemia, insulin resistance, and raised leptin and oestrogens. The Spanish Society for the Study of Obesity and the Spanish Society of Medical Oncology have signed a cooperation agreement to work together towards reducing the impact of obesity in cancer. Preventing obesity prevents cancer.
['Goday|A|A|', 'Barneto|I|I|', 'García-Almeida|J M|JM|', 'Blasco|A|A|', 'Lecube|A|A|', 'Grávalos|C|C|', 'Martínez de Icaya|P|P|', 'de las Peñas|R|R|', 'Monereo|S|S|', 'Vázquez|L|L|', 'Palacio|J E|JE|', 'Pérez-Segura|P|P|']
D054392:Adipokines D001943:Breast Neoplasms D015179:Colorectal Neoplasms D016207:Cytokines D016889:Endometrial Neoplasms D004938:Esophageal Neoplasms D005260:Female D006801:Humans D007249:Inflammation D007328:Insulin D007333:Insulin Resistance D007334:Insulin-Like Growth Factor I D007680:Kidney Neoplasms D008297:Male D009364:Neoplasm Recurrence, Local D009369:Neoplasms D009765:Obesity D010190:Pancreatic Neoplasms D012307:Risk Factors D012955:Societies, Medical D013030:Spain
Inflammatory cytokines Insulin Adipokines BMI Fatty acids IGF1 and 2