Samin-derived flavonolignans, a new series of antidiabetic agents having dual inhibition against α-glucosidase and free radicals.
A series of novel flavonolignans were synthesized by the reaction between a lignan named samin (1) and a range of flavonoids. This simple and rapid approach allowed direct assembly of these two bulky motifs in good yields without the formation of byproducts. Upon evaluation of antidiabetic activity of the synthesized products, epicatechinosamin (β-2g) was the most active α-glucosidase inhibitor toward maltase and sucrase. The kinetic study indicated that β-2 g inhibited the enzymes in a mixed manner of competitive and noncompetitive inhibition.
['Worawalai|Wisuttaya|W|', 'Phuwapraisirisan|Preecha|P|']
D000975:Antioxidants D005419:Flavonoids D044947:Flavonolignans D005609:Free Radicals D065089:Glycoside Hydrolase Inhibitors D007004:Hypoglycemic Agents D007700:Kinetics D009682:Magnetic Resonance Spectroscopy D015394:Molecular Structure D000520:alpha-Glucosidases
Flavonolignan Friedel-Crafts antioxidant diabetes glucosidase oxocarbenium