Facile preparation of doxorubicin-loaded upconversion@polydopamine nanoplatforms for simultaneous in vivo multimodality imaging and chemophotothermal synergistic therapy.
The development of biosafe nanoplatforms with diagnostic and therapeutic multifunction is extremely demanded for designing cancer theranostic medicines. Here, a facile methodology is developed to construct a multifunctional nanotheranostic that gathers five functions, upconversion luminescence (UCL) imaging, T1-weighted magnetic resonance imaging (MRI), X-ray computed tomography (CT) imaging, photothermal therapy (PTT), and chemotherapy, into one single nanoprobe (named as UCNP@PDA5-PEG-DOX). For generating the UCNP@PDA5-PEG-DOX, a near-infrared light (NIR)-absorbing polydopamine (PDA) shell is directly coated on oleic-acid-capped β-NaGdF4:Yb(3+),Er(3+)@β-NaGdF4 upconverting nanoparticle (UCNP) core for the first time to form monodisperse, ultrastable, and noncytotoxic core-shell-structured nanosphere via water-in-oil microemulsion approach. When combined with 808 nm NIR laser irradiation, the UCNP@PDA5-PEG-DOX shows great synergistic interaction between PTT and the enhanced chemotherapy, resulting in completely eradicated mouse-bearing SW620 tumor without regrowth. In addition, leakage study, hemolysis assay, histology analysis, and blood biochemistry assay unambiguously reveal that the UCNP@PDA5-PEG has inappreciable cytotoxicity and negligible organ toxicity. The results provide explicit strategy for fabricating multifunctional nanoplatforms from the integration of UCNP with NIR-absorbing polymers, important for developing multi-mode nanoprobes for biomedical applications.
['Liu|Fuyao|F|', 'He|Xiuxia|X|', 'Lei|Zhen|Z|', 'Liu|Liang|L|', 'Zhang|Junping|J|', 'You|Hongpeng|H|', 'Zhang|Huimao|H|', 'Wang|Zhenxin|Z|']
D000818:Animals D016923:Cell Death D045744:Cell Line, Tumor D002470:Cell Survival D004317:Doxorubicin D004357:Drug Synergism D004358:Drug Therapy D004705:Endocytosis D006801:Humans D007211:Indoles D060526:Magnetic Fields D008279:Magnetic Resonance Imaging D051379:Mice D064847:Multimodal Imaging D053758:Nanoparticles D010789:Phototherapy D011092:Polyethylene Glycols D011108:Polymers D019265:Spectroscopy, Near-Infrared D013696:Temperature D014057:Tomography, X-Ray Computed
multimodality imaging photothermal therapy chemotherapy polydopamine upconversion nanoparticle