Photo-Inspired Antibacterial Activity and Wound Healing Acceleration by Hydrogel Embedded with Ag/Ag@AgCl/ZnO Nanostructures.
Ag/Ag@AgCl/ZnO hybrid nanostructures are embedded in a hydrogel by a simple two-step technique. The Ag/Ag@AgCl nanostructures are assembled in the hydrogel via ultraviolet light chemical reduction followed by incorporation of ZnO nanostructures by NaOH precipitation. The hydrogel accelerates wound healing and exhibits high antibacterial efficiency against both Escherichia coli and Staphylococcus aureus under visible light irradiation. The Ag/Ag@AgCl nanostructures enhance the photocatalytic and antibacterial activity of ZnO due to the enhancement of reactive oxygen species by visible light. This hydrogel system kills 95.95% of E. coli and 98.49% of S. aureus within 20 min upon exposure to simulated visible light, and rapid sterilization plays a crucial role in wound healing. In addition, this system provides controllable, sustained release of silver and zinc ions over a period of 21 days arising from the reversible swelling-shrinking transition of the hydrogel triggered by the changing pH value in the biological environment. About 90% Zn2+ release is observed in the acidic environment after 3 days, whereas only 10% Zn2+ release occurs in the neutral environment after 21 days. In vivo results show that release of Ag+ and Zn2+ stimulates the immune function to produce a large number of white blood cells and neutrophils (2-4 times more than the control), thereby producing the synergistic antibacterial effects and accelerated wound healing.
['Mao|Congyang|C|', 'Xiang|Yiming|Y|', 'Liu|Xiangmei|X|', 'Cui|Zhenduo|Z|', 'Yang|Xianjin|X|', 'Yeung|Kelvin Wai Kwok|KWK|', 'Pan|Haobo|H|', 'Wang|Xianbao|X|', 'Chu|Paul K|PK|', 'Wu|Shuilin|S|0000-0002-1270-1870']
D000818:Animals D000900:Anti-Bacterial Agents D002460:Cell Line D004926:Escherichia coli D004927:Escherichia coli Infections D006801:Humans D020100:Hydrogels D008027:Light D008297:Male D051379:Mice D049329:Nanostructures D010778:Photochemotherapy D017319:Photosensitizing Agents D017208:Rats, Wistar D012834:Silver D018030:Silver Compounds D013203:Staphylococcal Infections D013211:Staphylococcus aureus D014945:Wound Healing D015034:Zinc Oxide
antibacterial activity wound healing hydrogel visible light irradiation photodynamic therapy