A Case with 68Ga-FAPI Positive and 18F-FDG Negative Breast Cancer
A female patient diagnosed of infiltrative breast carcinoma using tru-cut biopsy underwent 18flourine-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for staging. The tumor was located in the superior external quadrant of the right breast, and did not exhibit pathological uptake in 18F-FDG PET/CT. Later, gallium-68 (68Ga) fibroblast activation protein-specific inhibitor (FAPI)-04 PET/CT imaging was performed and the primary tumor showed intense radiotracer accumulation. This presumes that 68Ga-FAPI PET/CT imaging is superior to 18F-FDG imaging in detecting the primary tumor in breast cancer, thereby suggesting the replacement of FAPI by 18F-FDG in breast-cancer staging in the future.
['Kömek|Halil|H|0000-0001-8168-136X', 'Gündoğan|Cihan|C|0000-0001-5700-6292', 'Etem|Hülya|H|0000-0002-0469-2716', 'Can|Canan|C|0000-0002-0255-5830']
68Ga-FAPI 18F-FDG PET/CT breast cancer