Protecting the Aging Genome.
Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of defense have evolved to reduce the accumulation of DNA damage, including reducing damaging molecules, repairing DNA damage, and inducing senescence or apoptosis in response to persistent DNA damage. Mutations in or failure of these pathways can lead to accelerated or premature aging and age-related decline in vital organs, supporting the hypothesis that maintaining a pristine genome is paramount for human health. Understanding how we cope with DNA damage could inform on the aging process and further on how deficient DNA maintenance manifests in age-related phenotypes. This knowledge may lead to the development of novel interventions promoting healthspan.
['Petr|Michael A|MA|', 'Tulika|Tulika|T|', 'Carmona-Marin|Lina M|LM|', 'Scheibye-Knudsen|Morten|M|']
D000375:Aging D000818:Animals D016922:Cellular Senescence D004249:DNA Damage D004260:DNA Repair D016678:Genome D006801:Humans D009154:Mutation
aging DNA damage DNA repair aging interventions progeria