The Association of Dietary Patterns with High-Risk Human Papillomavirus Infection and Cervical Cancer: A Cross-Sectional Study in Italy.
Specific foods and nutrients help prevent the progression of persistent high-risk human papillomavirus (hrHPV) infection to cervical cancer (CC). The aim of this study was to investigate dietary patterns which may be associated with hrHPV status and the risk of high-grade cervical intraepithelial neoplasia (CIN2+). Overall, 539 eligible women, including 127 with CIN2+, were enrolled in a cross-sectional study, and tested for hrHPV infection. Food intake was estimated using a food frequency questionnaire. Logistic regression models were applied. Using the Mediterranean Diet Score, we demonstrated that, among 252 women with a normal cervical epithelium, medium adherence to the Mediterranean diet decreased the odds of hrHPV infection when compared to low adherence (adjOR = 0.40, 95%CI = 0.22-0.73). Using the principal component analysis, we also identified two dietary patterns which explained 14.31% of the variance in food groups intake. Women in the third and fourth quartiles of the "Western pattern" had higher odds of hrHPV infection when compared with first quartile (adjOR = 1.77, 95% CI = 1.04-3.54 and adjOR = 1.97, 95%CI = 1.14-4.18, respectively). Adjusting for hrHPV status and age, women in the third quartile of the "prudent pattern" had lower odds of CIN2+ when compared with those in the first quartile (OR = 0.50, 95%CI = 0.26-0.98). Our study is the first to demonstrate the association of dietary patterns with hrHPV infection and CC and discourages unhealthy habits in favour of a Mediterranean-like diet.
['Barchitta|Martina|M|', 'Maugeri|Andrea|A|', 'Quattrocchi|Annalisa|A|', 'Agrifoglio|Ottavia|O|0000-0002-3496-3097', 'Scalisi|Aurora|A|', 'Agodi|Antonella|A|']
D000328:Adult D016022:Case-Control Studies D018290:Cervical Intraepithelial Neoplasia D016009:Chi-Square Distribution D003430:Cross-Sectional Studies D000072001:Diet, Healthy D038441:Diet, Mediterranean D004435:Eating D005247:Feeding Behavior D005260:Female D006801:Humans D007558:Italy D016014:Linear Models D016015:Logistic Models D008875:Middle Aged D060787:Neoplasm Grading D016017:Odds Ratio D030361:Papillomavirus Infections D025341:Principal Component Analysis D065840:Protective Factors D018570:Risk Assessment D012307:Risk Factors D040242:Risk Reduction Behavior D011795:Surveys and Questionnaires D002583:Uterine Cervical Neoplasms
cervical intraepithelial neoplasia Mediterranean diet score principal component analysis Western diet prudent diet