The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease.
Alzheimer's disease (EOAD, LOAD), mild cognitive impairment (MCI), Parkinson's disease (PD) and healthy controls were included to determine the serum interleukin-1s (IL-1α, IL-1β), IL-6 and alpha-2-macroglobulin (α2M) levels using ELISA. IL-6 might be a significant contributor to the inflammatory response in LOAD. The MCI data indicate that IL-1s, α2M and BDNF are somehow related, and this relationship might allow MCI patients to be more similar to the healthy controls. A correlation analysis of multiple biomarkers in different neurodegenerative disorders might be more useful than determining the levels of a single cytokine in a single disorder.
['Dursun|Erdinç|E|', 'Gezen-Ak|Duygu|D|', 'Hanağası|Haşmet|H|', 'Bilgiç|Başar|B|', 'Lohmann|Ebba|E|', 'Ertan|Sibel|S|', 'Atasoy|İrem L|İL|', 'Alaylıoğlu|Merve|M|', 'Araz|Ömür Selin|ÖS|', 'Önal|Burak|B|', 'Gündüz|Ayşegül|A|', 'Apaydın|Hülya|H|', 'Kızıltan|Güneş|G|', 'Ulutin|Turgut|T|', 'Gürvit|Hakan|H|', 'Yılmazer|Selma|S|']
D017668:Age of Onset D000368:Aged D000369:Aged, 80 and over D000544:Alzheimer Disease D015415:Biomarkers D019208:Brain-Derived Neurotrophic Factor D060825:Cognitive Dysfunction D004797:Enzyme-Linked Immunosorbent Assay D005260:Female D006801:Humans D007249:Inflammation D053582:Interleukin-1alpha D053583:Interleukin-1beta D015850:Interleukin-6 D008297:Male D008875:Middle Aged D010300:Parkinson Disease D000511:alpha-Macroglobulins
Alzheimer's disease Mild cognitive impairment (MCI) Parkinson's disease (PD) Biomarker Alpha-2 macroglobulin (α2-macroglobulin) Brain derived neurotrophic factor (BDNF) Heat shock protein 90 (Hsp90) Interleukin 1 alpha (IL-1α) Interleukin 1 beta (IL-1β) Interleukin 10 (IL-10) Interleukin 6 (IL-6) Tumor necrosis factor alpha (TNFα)