Two New Terpenes Isolated from Dictyostelium Cellular Slime Molds.
We report a protoilludane-type sesquiterpene, mucoroidiol, and a geranylated bicyclogermacranol, firmibasiol, isolated from Dictyostelium cellular slime molds. The methanol extracts of the fruiting bodies of cellular slime molds were separated by chromatographic methods to give these compounds. Their structures have been established by several spectral means. Mucoroidiol and firmibasiol are the first examples of more modified and oxidized terpenoids isolated from cellular slime molds. Mucoroidiol showed moderate osteoclast-differentiation inhibitory activity despite demonstrating very weak cell-proliferation inhibitory activity. Therefore, cellular slime molds produce considerably diverse secondary metabolites, and they are promising sources of new natural product chemistry.
['Sasaki|Hitomi|H|', 'Kubohara|Yuzuru|Y|0000-0001-9231-9833', 'Ishigaki|Hirotaka|H|', 'Takahashi|Katsunori|K|', 'Eguchi|Hiromi|H|', 'Sugawara|Akihiro|A|0000-0003-1266-7497', 'Oshima|Yoshiteru|Y|', 'Kikuchi|Haruhisa|H|0000-0001-6938-0185']
D000818:Animals D000900:Anti-Bacterial Agents D000970:Antineoplastic Agents D053898:Biosynthetic Pathways D004023:Dictyostelium D004926:Escherichia coli D006367:HeLa Cells D006801:Humans D020128:Inhibitory Concentration 50 D009682:Magnetic Resonance Spectroscopy D051379:Mice D008826:Microbial Sensitivity Tests D010012:Osteogenesis D000067996:RAW 264.7 Cells D013211:Staphylococcus aureus D013729:Terpenes
cellular slime molds terpenoids natural products dictyostelid