Turner syndrome--issues to consider for transition to adulthood.
BACKGROUND
Turner syndrome (TS) is associated with a spectrum of health problems across the age span, which requires particular attention during the transition period in these adolescents.


AREAS OF AGREEMENT
The majority of girls with TS require oestrogen replacement from puberty onwards, which is important for adequate feminization, uterine development and maintenance of bone health. There is a lifetime increased risk from autoimmune conditions like hypothyroidism, coeliac disease, hearing loss and aortic dilatation with the potential to lead to aortic dissection. A systematic and holistic approach to provision of health care in TS is needed.


AREAS OF CONTROVERSY
Several unanswered questions remain, including the choice of hormone replacement therapy in the young person with TS and in adulthood; the optimal mode of cardiovascular assessment; the best management and assessment prior to and during pregnancy.


AREAS TIMELY FOR DEVELOPING RESEARCH
The optimal model of care and transition to adult services in TS requires attention. Further research is needed in relation to cardiovascular risk assessment, pregnancy management and hormone replacement therapy in TS.
['Lucaccioni|Laura|L|', 'Wong|Sze Choong|SC|', 'Smyth|Arlene|A|', 'Lyall|Helen|H|', 'Dominiczak|Anna|A|', 'Ahmed|S Faisal|SF|', 'Mason|Avril|A|']
D000293:Adolescent D000328:Adult D001327:Autoimmune Diseases D002648:Child D032921:Consensus D005260:Female D020249:Hormone Replacement Therapy D006801:Humans D007621:Karyotyping D017410:Practice Guidelines as Topic D011247:Pregnancy D011627:Puberty D012307:Risk Factors D060305:Transition to Adult Care D014424:Turner Syndrome D006113:United Kingdom
transition Turner syndrome puberty aortic dilatation aortic dissection hormone replacement therapy pregnancy