The organophosphate malathion disturbs gut microbiome development and the quorum-Sensing system.
The gut microbiome has tremendous potential to impact health and disease. Various environmental toxicants, including insecticides, have been shown to alter gut microbiome community structures. However, the mechanism that compositionally and functionally regulates gut microbiota remains unclear. Quorum sensing is known to modulate intra- and interspecies gene expression and coordinate population responses. It is unknown whether quorum sensing is disrupted when environmental toxicants cause perturbations in the gut microbiome community structure. To reveal the response of the quorum-sensing system to environmental exposure, we use a combination of Illumina-based 16S rRNA gene amplicon and shotgun metagenome sequencing to examine the impacts of a widely used organophosphate insecticide, malathion, on the gut microbiome trajectory, quorum sensing system and behaviors related to quorum sensing, such as motility and pathogenicity. Our results demonstrated that malathion perturbed the gut microbiome development, quorum sensing and quorum sensing related behaviors. These findings may provide a novel mechanistic understanding of the role of quorum-sensing in the gut microbiome toxicity of malathion.
['Gao|Bei|B|', 'Chi|Liang|L|', 'Tu|Pengcheng|P|', 'Bian|Xiaoming|X|', 'Thomas|Jesse|J|', 'Ru|Hongyu|H|', 'Lu|Kun|K|']
D000818:Animals D001419:Bacteria D002473:Cell Wall D000069196:Gastrointestinal Microbiome D016678:Genome D023281:Genomics D007306:Insecticides D008294:Malathion D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D053038:Quorum Sensing D012336:RNA, Ribosomal, 16S
Malathion Quorum sensing Gut microbiome toxicity