Serotonin transporter gene polymorphism in eating disorders: Data from a new biobank and META-analysis of previous studies.
UNLABELLED
Objectives Growing interest focuses on the association between 5-HTTLPR polymorphism and eating disorders (ED), but published findings have been conflicting. Methods The Italian BIO.VE.D.A. biobank provided 976 samples (735 ED patients and 241 controls) for genotyping. We conducted a literature search of studies published up to 1 April 2015, including studies reporting on 5HTTLPR genotype and allele frequencies in obesity and/or ED. We ran a meta-analysis, including data from BIO.VE.D.A. - comparing low and high-functioning genotype and allele frequencies in ED vs.


CONTROLS
Results Data from 21 studies, plus BIO.VE.D.A., were extracted providing information from 3,736 patients and 2,707 controls. Neither low- nor high-functioning genotype frequencies in ED patients, with both bi- and tri-allelic models, differed from controls. Furthermore, neither low- nor high-functioning allele frequencies in ED or in BN, in both bi- and triallelic models, differed from control groups. After sensitivity analysis, results were the same in AN vs.


CONTROLS
Results remained unaltered when investigating recessive and dominant models. Conclusions 5HTTLPR does not seem to be associated with ED in general, or with AN or BN in particular. Future studies in ED should explore the role of ethnicity and psychiatric comorbidity as a possible source of bias.
['Solmi|M|M|', 'Gallicchio|D|D|', 'Collantoni|E|E|', 'Correll|C U|CU|', 'Clementi|M|M|', 'Pinato|C|C|', 'Forzan|M|M|', 'Cassina|M|M|', 'Fontana|F|F|', 'Giannunzio|V|V|', 'Piva|I|I|', 'Siani|R|R|', 'Salvo|P|P|', 'Santonastaso|P|P|', 'Tenconi|E|E|', 'Veronese|N|N|', 'Favaro|A|A|']
D000856:Anorexia Nervosa D018070:Biological Specimen Banks D052018:Bulimia Nervosa D005787:Gene Frequency D020022:Genetic Predisposition to Disease D006801:Humans D009765:Obesity D011110:Polymorphism, Genetic D050486:Serotonin Plasma Membrane Transport Proteins
Eating disorders 5-HTTLPR anorexia nervosa binge eating bulimia nervosa