Molecular Subtypes, Apoptosis and Proliferation Status in Indonesian Diffuse Large B-Cell Lymphoma Cases
Objective: The diffuse large B-cell lymphoma (DLBCL) has two major molecular subtypes, germinal center
B-cell-like (GCB) and non-GCB. These have differing behavior which affects overall patient survival. However,
immunohistochemistry based molecular subtyping of Indonesian DLBCLs has been limited. This was the focus of the
present study, with a focus of attention on the apoptotic index (AI) and the proliferation index (PI) of the two molecular
subtypes. Materials and Methods: During the study period of 3.5 years, a total of 98 cases of DLBCL were identified.
Molecular subtypes and PI were determined by immunohistochemistry and TUNEL method was used to determine
the AI. Result: GCB accounted for 31 cases (31.6%) and non-GCB the remainder (68.4%). Gender showed a slight
male predominance (54 cases, 55.1%), with a higher incidence in the extra-nodal region (57 cases, 58.2%). The AI
and PI were significantly higher in GCB (p<0.001 in the Mann-Whitney test) and a Spearman correlation coefficient
test showed that PI was positively correlated with AI (r=0.673, p<0.001). Conclusion: The findings indicate that the
non-GCB subtype is more common than GCB in Indonesian DLBCL. GCB features significantly higher PI and AI,
which themselves appear linked.
['Snak|Yosinta|Y|', 'Indrawati|||', 'Widayati|Kartika|K|', 'Arfian|Nur|N|', 'Anggorowati|Nungki|N|']
DLBCL GCB apoptotic index proliferation index non−GCB