Open-label study of cognitive behavioural therapy for individuals with at-risk mental state: Feasibility in the Japanese clinical setting.
AIM
To date, most cognitive behavioural therapy (CBT) trials for individuals with at-risk metal state (ARMS) have been conducted in few Western countries and its feasibility in other regions, including Japan, has not been established.


METHODS
We designed an open-label pilot study. Fourteen ARMS participants received CBT over 6 months and were followed-up for 6 months.


RESULTS
Thirteen individuals completed the CBT intervention and assessments. The mean total score on the Positive and Negative Syndrome Scale improved from 60.2 to 46.0 after the intervention (Cohen's d = 1.1). The effects were maintained at the follow-up assessment. One participant transitioned to psychosis after the CBT intervention, and was the only patient who received antipsychotics.


CONCLUSIONS
We confirmed the feasibility of the provision of CBT for ARMS in Japan. Since overprescription of antipsychotics is a matter of great concern in Japan, CBT could be a valuable alternative treatment strategy.
['Matsumoto|Kazunori|K|0000-0002-5753-0104', 'Ohmuro|Noriyuki|N|0000-0001-6257-2715', 'Tsujino|Naohisa|N|', 'Nishiyama|Shimako|S|', 'Abe|Koichi|K|', 'Hamaie|Yumiko|Y|0000-0001-7335-7906', 'Katsura|Masahiro|M|', 'Inoue|Naomi|N|', 'Matsuoka|Hiroo|H|', 'Kawasaki|Yasuhiro|Y|', 'Kishimoto|Toshifumi|T|', 'Suzuki|Michio|M|', 'Mizuno|Masafumi|M|']
D000293:Adolescent D000328:Adult D015928:Cognitive Behavioral Therapy D005240:Feasibility Studies D005260:Female D006801:Humans D007564:Japan D008297:Male D001523:Mental Disorders D010865:Pilot Projects D062706:Prodromal Symptoms D055815:Young Adult
cognitive behavioural therapy at-risk mental state psychosis early intervention psychological treatment