Accuracy of mRNA HPV tests as a predictor of recurrence of precursor lesions and cervical cancer after conization: a systematic review and meta-analysis.
Objective: This systematic review evaluates the accuracy of mRNA HPV biomarker for the identification of cervical intra-epithelial neoplasia (CIN) or cervical cancer during a follow-up after conization, taking histopathology as reference standard. Methods: A search of electronic databases was performed, for studies published until June 2018. As results, after screening, five studies including 1148 patients met the inclusion criteria. Dichotomization was performed by CIN2+ versus CIN1-. By analyzing all five studies, a sensitivity of 62.4% (95% CI: 54.8-69.7), specificity of 91.9% (95% CI: 90.0-93.5) and area under the curve of 0.5685 were revealed. Conclusion: mRNA HPV assay presents a high specificity and is an adequate tool for cervical cancer screening in the follow-up after conization.
['Macedo|Ana Cristina L|ACL|', 'Borba|Cristini da Luz Moretti|CDLM|', 'Bavaresco|Daniela Vicente|DV|', 'Colonetti|Tamy|T|', 'Grande|Antonio José|AJ|', 'Rosa|Maria Inês da|MID|']
D052685:Alphapapillomavirus D005260:Female D006801:Humans D012333:RNA, Messenger D012008:Recurrence D012680:Sensitivity and Specificity D002583:Uterine Cervical Neoplasms
mRNA HPV recurrence cervical cancer conization meta-analysis biomarkers CIN screening HSIL diagnostic systematic review