Violacin A, a new chromanone produced by Streptomyces violaceoruber and its anti-inflammatory activity.
A new chromanone derivative, named violacin A (1), was isolated from the fermentation broth of Streptomyces violaceoruber as a potential anti-inflammatory compound. The structure of violacin A was established using comprehensive NMR spectroscopic data analysis together with UV, IR, and MS data. The anti-inflammatory effects and action mechanisms of violacin A were investigated in vitro. The results demonstrated that violacin A attenuated the production of NO, IL-1β, IL-6, and TNF-α as well as inhibited the expression of iNOS in LPS-induced RAW 264.7 cells. Additionally, Western blot and qRT-PCR results revealed that 1 down-regulated pro-inflammatory cytokines expression correlated with the suppression of NF-κB signaling pathway.
['Ma|Jian|J|', 'Cao|Bixuan|B|', 'Chen|Xiu|X|', 'Xu|Minjuan|M|', 'Bi|Xiaoxu|X|', 'Guan|Peipei|P|', 'Jiang|Yi|Y|', 'Xu|Jun|J|', 'Han|Li|L|', 'Huang|Xueshi|X|']
D000818:Animals D000894:Anti-Inflammatory Agents, Non-Steroidal D047169:Cyclotides D004305:Dose-Response Relationship, Drug D008070:Lipopolysaccharides D051379:Mice D015394:Molecular Structure D016328:NF-kappa B D052247:Nitric Oxide Synthase Type II D000067996:RAW 264.7 Cells D015398:Signal Transduction D013302:Streptomyces D013329:Structure-Activity Relationship
Violacin A Streptomyces violaceoruber NF-κB Anti-inflammation