The effects of changes in platelet-to-neutrophil ratios 24 hours after intravenous thrombolysis on prognosis in acute ischemic stroke patients.
OBJECTIVE
To investigate the prognostic value of Platelet-to-Neutrophil ratio on admission (PNR on admission) and 24 h after intravenous thrombolysis (24 h PNR) in acute ischemic stroke patients (AIS) patients.


PATIENTS AND METHODS
One hundred fifty-one ischemic stroke patients receiving intravenous thrombolysis were retrospectively recruited in this study. Complete blood count evaluations for PNR were conducted on admission and 24 h after the treatment of thrombolysis. The poor outcome at 3months was defined as the modified Rankin Scale of 3-6.


RESULTS
In multivariate logistic regression, PNR on admission (odds ratio [OR] = 0.967, 95 % confidence interval [CI] = 0.939-0.996; P = 0.028), and 24 h PNR(OR = 0.933, 95 %CI = 0.895-0.972; P = 0.004) were all independent indicators for the 3-month poor prognosis in ischemic stroke patients receiving intravenous thrombolysis. The area under the curve of PNR on admission to predict poor functional outcomes at 3 months was 0.645 (95 %CI = 0.558-0.732; P < 0.001), and the best predictive PNR on admission value was 41.35. After the treatment of thrombolysis, the area under the curve of 24 h PNR to predict poor functional outcomes at 3 months was 0.796 (95 %CI = 0.722-0.858; P < 0.001), and the best predictive 24 h PNR value was 31.03.


CONCLUSIONS
Both the PNR on admission and 24 h PNR were independently associated with poor functional outcomes. Compared with the PNR on admission, 24 h PNR may serve as a more reliable marker for a poor prognosis in ischemic stroke patients receiving intravenous thrombolysis.
['Pan|Hong|H|', 'Fu|Mei|M|', 'Ge|Wanqian|W|', 'Zhou|Chengye|C|']
D061605:Administration, Intravenous D000368:Aged D005260:Female D005343:Fibrinolytic Agents D000085542:Functional Status D006801:Humans D000083242:Ischemic Stroke D007958:Leukocyte Count D016015:Logistic Models D008297:Male D008875:Middle Aged D015999:Multivariate Analysis D009504:Neutrophils D016017:Odds Ratio D010976:Platelet Count D011379:Prognosis D012720:Severity of Illness Index D015912:Thrombolytic Therapy D010959:Tissue Plasminogen Activator
Intravenous thrombolysis Prognosis Acute ischemic stroke PNR 24h PNR