Association between serum vitamin D levels and gastric cancer: A retrospective chart analysis.
AIM
To determine whether there is an increased risk of gastric adenocarcinoma associated with vitamin D deficiency (VDd).


METHODS
A retrospective case control study was performed of all patients diagnosed with gastric adenocarcinoma between 2005 and 2015. After we excluded the patients without a documented vitamin D level, 49 patients were included in our study.


RESULTS
The average age of patients with gastric adenocarcinoma and documented vitamin D level was 64 years old (95%CI: 27-86) and average vitamin D level was 20.8 mg/dL (95%CI: 4-44). Compared to a matched control group, the prevalence of VDd/insufficiency in patients with gastric adenocarcinoma was significantly higher than normal vitamin D levels (83.7% vs 16.3%). Forty-one patients (83.7%) with adenocarcinoma showed VDd/insufficiency compared to 18 (37%) patients with normal vitamin D level without gastric cancer (OR: 8.8, 95%CI: 5-22, P value < 0.0001). The average age of males with gastric adenocarcinoma diagnosis was 60 years old vs 68 years old for females (P = 0.01). Stage II gastric adenocarcinoma was the most prevalent in our study (37%).


CONCLUSION
We reported a positive relationship between VDd and gastric adenocarcinoma, that is to say, patients with decreased VDd levels have an increased propensity for gastric adenocarcinoma.
['Vyas|Neil|N|', 'Companioni|Rafael Ching|RC|', 'Tiba|Melik|M|', 'Alkhawam|Hassan|H|', 'Catalano|Carmine|C|', 'Sogomonian|Robert|R|', 'Baum|Joel|J|', 'Walfish|Aaron|A|']
Vitamin D Gastric cancer Adenocarcinoma