Integrin αE (CD103) is induced but plays no pathogenic role in psoriasiform skin lesions of TGFβ1 transgenic mice.
T-cells expressing αE (CD103), an integrin induced by TGFβ on T-cells in vitro, accumulate within epithelia in inflammatory disorders, including psoriasis. However, it is unclear, if and how αE (CD103) contributes to skin inflammation. Using two complementary approaches, we have investigated αE (CD103) in psoriasis-like skin inflammation of mice with transgenic epidermal expression of human TGFβ1: αE (CD103) was inhibited by function-blocking antibodies in vivo, and double-mutants with additional αE (CD103)-depletion were generated in two different genetic backgrounds. Epidermal hTGFβ1 expression was associated with prominent expression of αE (CD103) on infiltrating cells. However, neither treatment with αE (CD103)-blocking antibodies nor deficiency of αE (CD103) in double-mutant mice altered the psoriasis-like phenotype. In addition, histopathological and flow cytometric analyses revealed similar pathological skin alterations and lymphocyte subgroups in the different mouse strains. Thus, while αE (CD103) expression is indeed associated with hTGFβ1 in vivo, it has little, if any, influence on the course of the psoriasis-like phenotype in K5.hTGFβ1 transgenic mice.
['Braun|Andrea|A|', 'Schlickum|Stephanie|S|', 'Dewert|Nadin|N|', 'Schön|Margarete|M|', 'Schön|Michael P|MP|']
D000818:Animals D000906:Antibodies D015703:Antigens, CD D003433:Crosses, Genetic D004817:Epidermis D005434:Flow Cytometry D006801:Humans D007249:Inflammation D039001:Integrin alpha Chains D051379:Mice D008807:Mice, Inbred BALB C D008810:Mice, Inbred C57BL D008813:Mice, Inbred ICR D008822:Mice, Transgenic D010641:Phenotype D011565:Psoriasis D013601:T-Lymphocytes D053773:Transforming Growth Factor beta1 D019076:Transgenes
TGFβ1 T-cells psoriasis Integrin αE(CD103)