The complete genome sequence of Bifidobacterium longum LTBL16, a potential probiotic strain from healthy centenarians with strong antioxidant activity.
B. longum LTBL16 is a potential probiotic strain that was isolated from healthy centenarians in Bama, China. In vitro experiments show that B. longum LTBL16 has a strong antioxidant activity and the complete genome of B. longum LTBL16 was sequenced in this work. The genome consists of one 2,430,682 bp circular chromosome that is plasmid free. The circular chromosome has a GC content of 61.23% and contains 2071 coding sequences (CDSs), 4 rRNA manipulators and 55 tRNA coding genes. Genetic analysis showed that at least five protein-coding genes were associated with antioxidant activity, and the abundance of these genes may be related to free radical scavenging rates and oxygen tolerance. In addition, the safety of B. longum LTBL16 was evaluated using a virulence factor database and antibiotic resistance gene database. The results indicate that B. longum LTBL16 has the good potential for the development and utilization as a probiotic.
['Huang|Guohong|G|', 'Pan|Haibo|H|', 'Zhu|Zhenjun|Z|', 'Li|Quanyang|Q|']
D000369:Aged, 80 and over D000975:Antioxidants D000069978:Bifidobacterium longum D024881:Drug Resistance, Bacterial D016680:Genome, Bacterial D006801:Humans D010802:Phylogeny D019936:Probiotics D017422:Sequence Analysis, DNA D037521:Virulence Factors
Bifidobacterium Healthy centenarians Oxygen resistance Scavenge free radical