The PKD-Dependent Biogenesis of TGN-to-Plasma Membrane Transport Carriers.
Membrane trafficking is essential for processing and transport of proteins and lipids and to establish cell compartmentation and tissue organization. Cells respond to their needs and control the quantity and quality of protein secretion accordingly. In this review, we focus on a particular membrane trafficking route from the trans-Golgi network (TGN) to the cell surface: protein kinase D (PKD)-dependent pathway for constitutive secretion mediated by carriers of the TGN to the cell surface (CARTS). Recent findings highlight the importance of lipid signaling by organelle membrane contact sites (MCSs) in this pathway. Finally, we discuss our current understanding of multiple signaling pathways for membrane trafficking regulation mediated by PKD, G protein-coupled receptors (GPCRs), growth factors, metabolites, and mechanosensors.
['Wakana|Yuichi|Y|0000-0001-7537-1293', 'Campelo|Felix|F|0000-0002-0786-9548']
D000818:Animals D001692:Biological Transport D002462:Cell Membrane D006801:Humans D011493:Protein Kinase C D015398:Signal Transduction D022161:Transport Vesicles D021601:trans-Golgi Network
membrane trafficking protein kinase D CARTS membrane contact sites Golgi complex lipid metabolism protein sorting