Effect of tiletamine-zolazepam on the intraocular pressure of the dog.
OBJECTIVE
To determine the effect of tiletamine-zolazepam (TZ) on canine intraocular pressure (IOP).


ANIMALS STUDIED
Six healthy dogs without ocular abnormalities were used in this study.


PROCEDURES
The study was carried out as a crossover experimental trial with a 7-day interval between treatments. TZ combination was administered intravenously (IV) at a dose of 5, 10, and 20 mg/kg (TZ5, TZ10, and TZ20, respectively). Following preanesthetic baseline readings of IOP, each dog received IV TZ and then the IOP values were measured every 10 min for 40 min in all treatments.


RESULTS
The baseline IOP values (mean ± standard deviation) for TZ5, TZ10, and TZ20 were 12.7 ± 0.8, 14.4 ± 1.2, and 15.3 ± 1.7 mmHg, and each IOP changed to 11.1 ± 1.1, 13.1 ± 1.4 and 13.5 ± 1.7 mmHg after intravenous administration of each TZ treatment, respectively. However, there were no statistical differences between baseline and post-treatment values.


CONCLUSIONS
The TZ combination had no clinically significant effect on IOP of the dog. This could be an option for induction or surgical procedures in dogs with ophthalmic problems when an increase in IOP is undesirable.
['Jang|Min|M|', 'Park|Sangwan|S|', 'Son|Won-Gyun|WG|', 'Jo|Sang-Min|SM|', 'Hwang|Hyeshin|H|', 'Seo|Kangmoon|K|', 'Lee|Inhyung|I|']
D000818:Animals D018592:Cross-Over Studies D004285:Dogs D004305:Dose-Response Relationship, Drug D004338:Drug Combinations D007275:Injections, Intravenous D007429:Intraocular Pressure D008297:Male D013992:Tiletamine D014065:Tonometry, Ocular D015041:Zolazepam
intraocular pressure dog tiletamine zolazepam