The association between Dietary Inflammatory Index scores and the prevalence of colorectal adenoma.
OBJECTIVE
The Dietary Inflammatory Index (DII)TM, which was developed to characterize the inflammatory potential of a person's diet, has been shown to be associated with inflammatory conditions such as cancer. The present study aimed to investigate the association between DII scores and colorectal adenoma (CRA), a pre-cancerous condition.


DESIGN
Responses to baseline dietary questionnaires were used calculate DII scores. In a cross-sectional study design, the association between DII scores and CRA prevalence was determined in men and women separately using logistic regression models.


SETTING
Ten cancer screening centres across the USA.


SUBJECTS
Participants were those included in the screening arm of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial.


RESULTS
Among the 44 278 individuals included in these analyses, men with diets in the most inflammatory quartile of DII scores had higher odds of all types of CRA (advanced, non-advanced and multiple (>1)) compared with those with diets in the least inflammatory quartile of DII scores. In fully adjusted models, compared with those with DII scores in quartile 1 (least inflammatory), males with DII scores in quartile 3 (adjusted odds ratio (aOR)=1·28; 95 % CI 1·12, 1·47) and quartile 4 (aOR=1·41; 95 % CI 1·23, 1·62) were more likely to have prevalent distal CRA. Higher DII scores, representing a more inflammatory diet, also were weakly associated with a higher prevalence of CRA in women.


CONCLUSIONS
Implementing an anti-inflammatory diet may be an effective means of primary prevention of CRA, especially in men.
['Haslam|Alyson|A|', 'Wagner Robb|Sara|S|', 'Hébert|James R|JR|', 'Huang|Hanwen|H|', 'Wirth|Michael D|MD|', 'Shivappa|Nitin|N|', 'Ebell|Mark H|MH|']
D000368:Aged D015992:Body Mass Index D015179:Colorectal Neoplasms D003430:Cross-Sectional Studies D004032:Diet D004034:Diet Surveys D004043:Dietary Fiber D005260:Female D006801:Humans D007249:Inflammation D016015:Logistic Models D008297:Male D008875:Middle Aged D015995:Prevalence D012307:Risk Factors D012959:Socioeconomic Factors D011795:Surveys and Questionnaires
Dietary Inflammatory Index Colorectal adenoma Racial disparities