Do lamin B1 and lamin B2 have redundant functions?
Lamins B1 and B2 have a high degree of sequence similarity and are widely expressed from the earliest stages of development. Studies of Lmnb1 and Lmnb2 knockout mice revealed that both of the B-type lamins are crucial for neuronal migration in the developing brain. These observations naturally posed the question of whether the two B-type lamins might play redundant functions in the development of the brain. To explore that issue, Lee and coworkers generated "reciprocal knock-in mice" (knock-in mice that produce lamin B1 from the Lmnb2 locus and knock-in mice that produce lamin B2 from the Lmnb1 locus). Both lines of knock-in mice manifested neurodevelopmental abnormalities similar to those in conventional knockout mice, indicating that lamins B1 and B2 have unique functions and that increased production of one B-type lamin cannot compensate for the loss of the other.
['Lee|John M|JM|', 'Jung|Hea-Jin|HJ|', 'Fong|Loren G|LG|', 'Young|Stephen G|SG|']
D000818:Animals D001921:Brain D034921:Lamin Type B D051379:Mice D018345:Mice, Knockout D009685:Nuclear Envelope D034881:Nuclear Lamina
lamin B1 lamin B2 nuclear envelope nuclear lamina