Regulation of growth in Drosophila melanogaster: the roles of mitochondrial metabolism.
Mitochondrial functions are often considered purely from the standpoint of catabolism, but in growing cells they are mainly dedicated to anabolic processes, and can have a profound impact on the rate of growth. The Drosophila larva, which increases in body mass ∼200-fold over the course of ∼3 days at 25°C, provides an excellent model to study the underlying regulatory machinery that connects mitochondrial metabolic capacity to growth. In this review, we will focus on several key aspects of this machinery: nutrient sensing, endocrine control of feeding and nutrient mobilization, metabolic signalling, protein synthesis regulation and pathways of steroid biosynthesis and activity. In all these aspects, mitochondria appear to play a crucial role.
['Jacobs|Howard T|HT|', 'George|Jack|J|', 'Kemppainen|Esko|E|']
D000818:Animals D029721:Drosophila Proteins D004331:Drosophila melanogaster D004440:Ecdysone D051034:Inhibitor of Apoptosis Proteins D007814:Larva D008928:Mitochondria D000078622:Nutrients D042925:Positive Transcriptional Elongation Factor B D014176:Protein Biosynthesis D060449:Wnt Signaling Pathway
PGC-1 ecdysone insulin signalling proteostasis pyruvate