Pathways of heme utilization in fungi.
Iron acquisition is challenging in most environments. As an alternative to elemental iron, organisms can take up iron-protoporphyrin IX, or heme. Heme can be found in decaying organic matter and is particularly prevalent in animal hosts. Fungi have evolved at least three distinct endocytosis-mediated heme uptake systems, which have been studied in detail in the organisms Candida albicans, Cryptococcus neoformans and Schizosaccharomyces pombe. Here we summarize the known molecular details of these three uptake systems that enable parasitic and saprophytic fungi to take advantage of external heme as either cellular iron or heme sources.
['Kornitzer|Daniel|D|', 'Roy|Udita|U|']
D002176:Candida albicans D003455:Cryptococcus neoformans D004705:Endocytosis D006418:Heme D007501:Iron D011524:Protoporphyrins D012568:Schizosaccharomyces D015398:Signal Transduction
Heme Fungi Iron acquisition CFEM protein Hemophore