Imaging-Based Treatment Adaptation in Radiation Oncology.
In many tumor types, significant effort is being put into patient-tailored adaptation of treatment to improve outcome and preferably reduce toxicity. These opportunities first arose with the introduction of modern irradiation techniques (e.g., intensity-modulated radiotherapy) combined with functional imaging for more precise delineation of target volume. On the basis of functional CT, MRI, and PET results, radiation target volumes are altered during the course of treatment, or subvolumes inside the primary tumor are defined to enhance the dosing strategy. Moreover, the probability of complications to normal tissues is predicted using anatomic or functional imaging, such as in the use of CT or PET to predict radiation pneumonitis. Besides focusing, monitoring, and adapting photon therapy for solid tumors, PET also has a role in verifying proton-beam therapy. This article discusses the current state and remaining challenges of imaging-based treatment adaptation in radiation oncology.
['Troost|Esther G C|EG|', 'Thorwarth|Daniela|D|', 'Oyen|Wim J G|WJ|']
D006801:Humans D008279:Magnetic Resonance Imaging D057054:Molecular Imaging D009369:Neoplasms D049268:Positron-Emission Tomography D018787:Radiation Oncology D014057:Tomography, X-Ray Computed
functional CT PET/CT functional MRI theranostics