Antifungal and wound healing promotive compounds from the resins of Dracaena cochinchinensis.
Five new compounds (xuejieins A-E), including three new phenolic glycosides (1, 2, and 5) and two new flavonoids (10 and 11), together with six known compounds were isolated from the resins of Dracaena cochinchinensis (Chinese dragon's blood). The structures of the new compounds were confirmed by extensive spectroscopic methods and electronic circular dichroism (ECD) data analysis. Especially, the absolute configurations of the sugar moieties in compounds 1, 2, and 5 were clarified by GC analysis after acid hydrolysis. All isolated compounds have been tested for antifungal and wound healing promoting activities, The results showed that compound 9 shows significant antifungal activities against Botrytis cinerea, Magnaporthe grisea, Penicillium digitatum, and Sclerotinia sclerotiorum. In addition, compound 4 could significantly stimulate human keratinocytes (HaCAT) proliferation, mobility, and human umbilical vein vascular endothelial cells (HUVECs) tube formation at 40 μM.
['He|Tian-Chang|TC|', 'Wang|Dai-Wei|DW|', 'Zheng|Shu-Min|SM|', 'Yan|Yong-Ming|YM|', 'Jiao|Ya-Bin|YB|', 'Cheng|Yong-Xian|YX|', 'Wang|Feng|F|']
D000935:Antifungal Agents D002681:China D031409:Dracaena D005419:Flavonoids D006027:Glycosides D000084282:HaCaT Cells D061307:Human Umbilical Vein Endothelial Cells D006801:Humans D015394:Molecular Structure D064209:Phytochemicals D010936:Plant Extracts D012116:Resins, Plant D014945:Wound Healing
Wound healing promotive Dracaena cochinchinensis Phenolic glycosides Flavonoids Antifungal activities