Analysis of microvasculature phenotype and endothelial activation markers in skin lesions of lacaziosis (Lobomycosis).
Jorge Lobo's disease is a rare mycosis characterized by chronic inflammation, which causes skin lesions in the absence of visceral dissemination. The disease occurs mainly in hot and humid climates and most cases have been registered in the Brazilian Amazon region. This study investigated possible microvascular alterations in skin lesions caused by infection with Lacazia loboi which may interfere with the clinical progression of the disease. Immunohistochemistry was used to evaluate the density of blood and lymphatic vessels, as well as expression of the cell adhesion molecules ICAM-1, VCAM-1 and E-selectin. The results showed a reduced number of blood (62.66 ± 20.30 vessels/mm(2)) and lymphatic vessels (3.55 ± 5.84 vessels/mm(2)) in Jorge Lobo's disease when compared to control skin (169.66 ± 66.38 blood vessels/mm(2) and 8 ± 2.17 lymphatic vessels/mm(2)). There were a larger number of vessels expressing ICAM-1 (27.58 ± 15.32 vessels/mm(2)) and VCAM-1 (7.55 ± 6.2 vessels/mm(2)). No difference was observed in the expression of E-selectin (4.66 ± 11 vessels/mm(2)). Taken together, the results indicate changes in the local microvasculature which may interfere with the development of an efficient cell-mediated immune response and may explain restriction of the fungus to the site of injury.
['Quaresma|Juarez A S|JA|', 'Brito|Maysa V|MV|', 'Sousa|Jorge R|JR|', 'Silva|Luciana M|LM|', 'Hirai|Kelly E|KE|', 'Araujo|Rafael S|RS|', 'de Brito|Arival C|AC|', 'Carneiro|Francisca R O|FR|', 'Fuzii|Hellen T|HT|', 'Pagliari|Carla|C|', 'Sotto|Mirian N|MN|', 'Duarte|Maria I S|MI|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D015415:Biomarkers D001938:Brazil D019040:E-Selectin D042783:Endothelial Cells D005260:Female D006801:Humans D007150:Immunohistochemistry D018799:Intercellular Adhesion Molecule-1 D060367:Lacazia D060368:Lobomycosis D008297:Male D055806:Microvessels D008875:Middle Aged D012867:Skin D019010:Vascular Cell Adhesion Molecule-1 D055815:Young Adult
Microvasculature Jorge Lobo's disease ICAM-1 VCAM-1 E-selectin