The Impact of Vitamin D, Calcium, Protein Supplementation, and Physical Exercise on Bone Metabolism After Bariatric Surgery: The BABS Study.
Laparoscopic Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are common and effective methods to treat severe obesity, but these procedures can adversely influence bone metabolism and areal bone mineral density (aBMD). This was a prospective 24-month single-center interventional two-arm study in 220 women and similarly aged men (median age 40.7 years) with a body mass index (BMI) >38 kg/m(2) after RYGB and SG procedures. Patients were randomized into: 1) an intervention group receiving: 28,000 IU cholecalciferol/wk for 8 weeks before bariatric surgery, 16,000 IU/wk and 1000 mg calciummonocitrate/d after surgery, daily BMI-adjusted protein supplementation and physical exercise (Nordic walking, strength perseverance, and equipment training); 2) a non-intervention group: no preoperative loading, nutritional supplementation, or obligatory physical exercise. At study endpoint, when comparing the intervention group to the non-intervention group, the relative percentage changes of serum levels of sclerostin (12.1% versus 63.8%), cross-linked C-telopeptide (CTX, 82.6% versus 158.3%), 25-OH vitamin D (13.4% versus 18.2%), phosphate (23.7% versus 32%, p < 0.001 for all), procollagen type 1 amino-terminal propeptide (P1NP, 12% versus 41.2%), intact parathyroid hormone (iPTH, -17.3% versus -7.6%), and Dickkopf-1 (-3.9% versus -8.9%, p < 0.05 for all) differed. The decline in lumbar spine, total hip and total body aBMD, changes in BMI, lean body mass (LBM), as well as changes in trabecular bone score (TBS) values (p < 0.005 for all) were less, but significantly, pronounced in the intervention group. We conclude that vitamin D loading and ongoing vitamin D, calcium, and BMI-adjusted protein supplementation in combination with physical exercise decelerates the loss of aBMD and LBM after bariatric surgery. Moreover, the well-known increases of bone turnover markers are less pronounced.
['Muschitz|Christian|C|', 'Kocijan|Roland|R|', 'Haschka|Judith|J|', 'Zendeli|Afrodite|A|', 'Pirker|Thomas|T|', 'Geiger|Corinna|C|', 'Müller|Andrea|A|', 'Tschinder|Bettina|B|', 'Kocijan|Annemarie|A|', 'Marterer|Christina|C|', 'Nia|Arastoo|A|', 'Muschitz|Gabriela Katharina|GK|', 'Resch|Heinrich|H|', 'Pietschmann|Peter|P|']
D015502:Absorptiometry, Photon D000328:Adult D050110:Bariatric Surgery D015415:Biomarkers D015519:Bone Density D016723:Bone Remodeling D001842:Bone and Bones D002136:Calcium, Dietary D003710:Demography D004044:Dietary Proteins D019587:Dietary Supplements D015444:Exercise D005215:Fasting D005260:Female D006801:Humans D016014:Linear Models D008297:Male D011788:Quality of Life D014807:Vitamin D
BIOCHEMICAL MARKERS OF BONE TURNOVER BONE-FAT INTERACTIONS CLINICAL TRIALS DXA