Recent studies on cellular and molecular mechanisms in Alzheimer's disease: focus on epigenetic factors and histone deacetylase.
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders mainly affecting elderly people. It is characterized by progressive loss of memory and cognitive function. More than 95% of AD cases are related to sporadic or late-onset AD (LOAD). The etiology of LOAD is still unclear. It has been reported that environmental factors and epigenetic alterations play a significant role in AD pathogenesis. Furthermore, recently, genome-wide association studies (GWAS) identified 10 novel risk genes: ABCA7, APOE, BIN1, CD2AP, CD33, CLU, CR1, MS4A6A, MS4A4E, and PICALM, which play an important role for LOAD. In this review, the therapeutic approaches of AD by epigenetic modifications have been discussed. Nowadays, HDAC inhibitors have clinically proven its activity for epigenetic modifications. Furthermore, we try to establish the relationship between HDAC inhibitors and above mentioned LOAD risk genes. Finally, we are hoping that this review may open new area of research for AD treatment.
['Dubey|Harikesh|H|', 'Gulati|Kavita|K|', 'Ray|Arunabha|A|']
D000375:Aging D000544:Alzheimer Disease D000818:Animals D003072:Cognition Disorders D044127:Epigenesis, Genetic D020022:Genetic Predisposition to Disease D055106:Genome-Wide Association Study D056572:Histone Deacetylase Inhibitors D006655:Histone Deacetylases D006801:Humans
LOAD GWAS epigenetic modification HDAC inhibitors Alzheimer’s disease