IL-10 and PRKDC polymorphisms are associated with glioma patient survival.
Interleukin-10 (IL-10) and DNA repair gene PRKDC mutations are implicated in the development of multiple human cancers, including glioma. We investigated associations between IL-10 and PRKDC gene polymorphisms and prognosis in low- and high-grade glioma patients. We analyzed the associations of one IL-10 and one PRKDC single nucleotide polymorphism with patient clinical factors in 481 glioma patients using Cox proportional hazard models and Kaplan-Meier curves. We also assessed associations between patient clinical characteristics and prognosis. Our data showed that the extent of tumor resection (gross-total resection) and application of chemotherapy were associated with improved patient outcomes in all glioma cases. Additionally, univariate (Log-rank p = 0.019) and multivariate Cox regression analyses (p = 0.022) showed that the IL-10 rs1800871 C/T genotype correlates with improved overall survival in cases of low-grade glioma, whereas the PRKDC rs7003908 C/C genotype correlated with reduced overall and progression-free survival in high-grade glioma patients in univariate (Log-rank p = 0.000 and p = 0.000, respectively) and multivariate Cox regression analyses (p = 0.001; p = 0.002, respectively). These results suggest that IL-10 rs1800871 and PRKDC rs7003908 may be useful biomarkers for predicting glioma patient outcome. Further functional studies are needed to evaluate the mechanisms by which these polymorphisms affect glioma progression.
['Hu|Mingjun|M|', 'Du|Jieli|J|', 'Cui|Lihong|L|', 'Huang|Tingqin|T|', 'Guo|Xiaoye|X|', 'Zhao|Yonglin|Y|', 'Ma|Xudong|X|', 'Jin|Tianbo|T|', 'Li|Gang|G|', 'Song|Jinning|J|']
D000328:Adult D014408:Biomarkers, Tumor D001932:Brain Neoplasms D002681:China D051747:DNA-Activated Protein Kinase D018450:Disease Progression D018572:Disease-Free Survival D005260:Female D020022:Genetic Predisposition to Disease D005910:Glioma D006801:Humans D016753:Interleukin-10 D053208:Kaplan-Meier Estimate D008297:Male D015999:Multivariate Analysis D060787:Neoplasm Grading D009687:Nuclear Proteins D010641:Phenotype D020641:Polymorphism, Single Nucleotide D016016:Proportional Hazards Models D012307:Risk Factors D013997:Time Factors D016896:Treatment Outcome
IL-10 PRKDC polymorphism glioma biomarker