Biology and function of adipose tissue macrophages, dendritic cells and B cells.
The increasing incidence of obesity and its socio-economical impact is a global health issue due to its associated co-morbidities, namely diabetes and cardiovascular disease [1-5]. Obesity is characterized by an increase in adipose tissue, which promotes the recruitment of immune cells resulting in low-grade inflammation and dysfunctional metabolism. Macrophages are the most abundant immune cells in the adipose tissue of mice and humans. The adipose tissue also contains other myeloid cells (dendritic cells (DC) and neutrophils) and to a lesser extent lymphocyte populations, including T cells, B cells, Natural Killer (NK) and Natural Killer T (NKT) cells. While the majority of studies have linked adipose tissue macrophages (ATM) to the development of low-grade inflammation and co-morbidities associated with obesity, emerging evidence suggests for a role of other immune cells within the adipose tissue that may act in part by supporting macrophage homeostasis. In this review, we summarize the current knowledge of the functions ATMs, DCs and B cells possess during steady-state and obesity.
['Ivanov|Stoyan|S|', 'Merlin|Johanna|J|', 'Lee|Man Kit Sam|MKS|', 'Murphy|Andrew J|AJ|', 'Guinamard|Rodolphe R|RR|']
D054392:Adipokines D000273:Adipose Tissue D050154:Adiposity D000818:Animals D001402:B-Lymphocytes D002450:Cell Communication D016207:Cytokines D003713:Dendritic Cells D006801:Humans D018836:Inflammation Mediators D008264:Macrophages D009765:Obesity D010641:Phenotype D015398:Signal Transduction
Adipose tissue Macrophage Dendritic cell B cell Obesity