Local Contrasts in Concentration of Ambient Particulate Air Pollution (PM2.5) and Incidence of Alzheimer's Disease and Dementia: Results from the Betula Cohort in Northern Sweden.
Exposure to fine particulate air pollution (PM2.5) is emerging as a risk factor for Alzheimer's disease (AD), but existing studies are still limited and heterogeneous. We have previously studied the association between dementia (AD and vascular dementia) and PM2.5 stemming from vehicle exhaust and wood-smoke in the Betula cohort in Northern Sweden. The aim of this commentary is to estimate the association between total PM2.5 and dementia in the Betula cohort, which is more relevant to include in future meta-estimates than the source-specific estimates. The hazard ratio for incident dementia associated with a 1μg/m3 increase in local PM2.5 was 1.38 (95% confidence interval: 0.99 -1.92). The interpretation of our results is that they indicate an association between local contrasts in concentration of PM2.5 at the residential address and incidence of dementia in a low-level setting.
['Åström|Daniel Oudin|DO|', 'Adolfsson|Rolf|R|', 'Segersson|David|D|', 'Forsberg|Bertil|B|', 'Oudin|Anna|A|']
D000397:Air Pollution D000544:Alzheimer Disease D003704:Dementia D004781:Environmental Exposure D006801:Humans D015994:Incidence D052638:Particulate Matter D013548:Sweden
particulate air pollution Air pollution PM2.5 dementia Alzheimer’s disease