Predicting Later Study Withdrawal in Participants Active in a Longitudinal Birth Cohort Study for 1 Year: The TEDDY Study.
OBJECTIVE
To identify predictors of later study withdrawal among participants active in The Environmental Determinants of Diabetes in the Young (TEDDY) for 1 year.


METHODS
Multiple logistic regression was used to discriminate 3,042 children active in TEDDY for the first 3 years from 432 children who withdrew in Years 2 or 3. Predictor variables were tested in blocks-demographic, maternal lifestyle behaviors, stress and child illness, maternal reactions to child's increased diabetes risk, in-study behaviors-and a final best model developed.


RESULTS
Few demographic factors predicted study withdrawal. Maternal lifestyle behaviors, accuracy of the mother's risk perception, and in-study behaviors were more important. Frequent child illnesses were associated with greater study retention.


CONCLUSIONS
Demographic measures are insufficient predictors of later study withdrawal among those active in a study for at least 1 year; behavioral/psychological factors offer improved prediction and guidance for the development of retention strategies.
['Johnson|Suzanne Bennett|SB|', 'Lynch|Kristian F|KF|', 'Baxter|Judith|J|', 'Lernmark|Barbro|B|', 'Roth|Roswith|R|', 'Simell|Tuula|T|', 'Smith|Laura|L|', '|||']
D002675:Child, Preschool D003922:Diabetes Mellitus, Type 1 D016021:Epidemiologic Studies D005260:Female D006801:Humans D007223:Infant D008019:Life Style D008137:Longitudinal Studies D008297:Male D009035:Mothers D015337:Multicenter Studies as Topic D010352:Patient Dropouts D012307:Risk Factors
diabetes adherence genetics and genetic disorders longitudinal research prevention/control research design and methods