Quercetin Confers Tumoricidal Activity Through Multipathway Mechanisms in A N-Methylnitrosourea Rat Model of Colon Cancer
Objective: This research was conducted to explore mechanisms behind the potency of quercetin in inhibiting
colon cancer induced in an experimental model. Materials and Methods: Forty adult male rats of Wistar strain were
distributed into 4 groups; a negative control group, a colon cancer bearing group, a quercetin-treated group and a
5-fluorouracil (5-FU)-treated group. Serum TAG72 and GAL3 levels were quantified by ELISA. Colonic Wnt5a and
Axin-1 gene expression was estimated by PCR. In addition, colonic tissues were subjected to immunohistochemical
examination of Bax expression and histological investigation of histopathological alterations. Results: Quercetin elicited
significant reduction in serum TAG72 and GAL3 levels, in addition to significant suppression of colonic Wnt5a gene
expression and amplification of colonic Axin-1 gene expression. Also, it caused moderate positive reaction for Bax in
mucosal epithelium. Conclusion: The present research provides experimental evidence about the activity of quercetin
in the colon cancer of rats. Inhibitory effects on cancer development might be ascribable to regulatory action on Wnt
signaling and induction of apoptosis.
['Ahmed|Hanaa H|HH|', 'Aglan|Hadeer A|HA|', 'Zaazaa|Asmaa M|AM|', 'Shalby|Aziza B|AB|', 'El Toumy|Sayed A|SA|']
quercetin rats Colon cancer 5-fluorouracil Wnt signaling