Chronic running and a corticosterone treatment attenuate astrocyte-like neural stem cell proliferation in the area postrema of the adult mouse brain.
The discovery of neural stem cells (NSCs) in the adult mammalian brain has provided insights into an extra level of brain plasticity. The proliferation and differentiation of NSCs is modulated by various physiological, pathological, and pharmacological stimuli. NSCs were recently detected in the medulla oblongata of adult rodents and humans; however, their functional significance currently remains unknown. In the present study, we examined the effects of chronic wheel-running and a corticosterone (CORT) treatment on the proliferation of astrocyte-like NSCs in the area postrema (AP) and dentate gyrus (DG). Chronic running significantly decreased the number of bromodeoxyuridine (BrdU)-labeled astrocyte-like NSCs in the AP of adult mice, but markedly increased that of BrdU+ NSCs/neural progenitor cells in the DG. The chronic CORT treatment markedly reduced the number of BrdU+ astrocyte-like NSCs in the AP, but not in the DG. These results demonstrate that the proliferation of astrocyte-like NSCs in the medulla oblongata is decreased by chronic running and a CORT treatment.
['Nambu|Yuri|Y|', 'Horie|Kohei|K|', 'Kurganov|Erkin|E|', 'Miyata|Seiji|S|']
D000818:Animals D031608:Area Postrema D001253:Astrocytes D001921:Brain D002454:Cell Differentiation D049109:Cell Proliferation D003345:Corticosterone D008297:Male D008810:Mice, Inbred C57BL D058953:Neural Stem Cells D055495:Neurogenesis D009474:Neurons
Running Corticosterone Neural stem cells Brain Adult neurogenesis