Two follicle-stimulating hormone receptor polymorphisms and polycystic ovary syndrome risk: a meta-analysis.
The aim of this study was to explore the association between follicle stimulating hormone receptor (FSHR) Thr307Ala and Asn680Ser polymorphisms and susceptibility to polycystic ovary syndrome (PCOS). A comprehensive literature search for relevant studies was conducted on Google Scholar, PubMed, the Chinese National Knowledge Infrastructure (CNKI) and the Chinese Biomedical Literature Database (CBM). This meta-analysis was performed using the STATA 11.0 software and the pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Ten case-control studies were included in this meta-analysis. However, meta-analysis results showed no association between both FSHR Thr307Ala polymorphism and Asn680Ser polymorphism and susceptibility to PCOS. Stratified analysis of ethnicities also showed no association. In conclusion, the present study suggested that the FSHR polymorphisms were not associated with an increased risk of PCOS and larger-scale studies of populations are needed to explore the roles played by FSHR polymorphisms during the pathogenesis of PCOS.
['Chen|Dao-Jun|DJ|', 'Ding|Rui|R|', 'Cao|Ji-Yu|JY|', 'Zhai|Jin-Xia|JX|', 'Zhang|Jia-Xiang|JX|', 'Ye|Dong-Qing|DQ|']
D016022:Case-Control Studies D005260:Female D020022:Genetic Predisposition to Disease D006801:Humans D011085:Polycystic Ovary Syndrome D011110:Polymorphism, Genetic D011962:Receptors, FSH D012307:Risk Factors
Polymorphism Meta-analysis FSHR PCOS