Randomised controlled trial of internet-delivered cognitive behaviour therapy for clinical depression and/or anxiety in cancer survivors (iCanADAPT Early).
PURPOSE
To evaluate internet-delivered cognitive behavioural therapy (iCBT) on clinical depression and/or anxiety, distress, fear of cancer recurrence, and quality of life in cancer survivors.


METHODS
Random assignation of 114 participants to iCBT or treatment-as-usual (TAU). The clinician-supervised iCBT program (iCanADAPT Early) consisted of eight lessons over 16 weeks. Self-report questionnaires occurred at baseline, midpoint, and posttreatment for both groups with 3-month follow-up for iCBT participants. A mixed modelling approach to compare groups occurred.


RESULTS
iCBT was superior to TAU on all outcome measures at posttreatment. Compared with TAU, the iCBT group showed a significant decrease over time in anxiety and depression symptoms (primary outcome, Hospital Anxiety and Depression Scale, Hedges g = 1.51). Additionally the iCBT group had significantly lower general distress (Kessler-10, g = 1.56), fear of cancer recurrence (Fear of Cancer Recurrence Inventory, g = 0.39), and significantly higher quality of life (Functional Assessment of Cancer Therapy-General, g = 0.74) at posttreatment compared with the TAU group. High adherence and satisfaction were found for iCBT with low clinician time.


CONCLUSION
Clinician-supervised iCBT has significant benefits for cancer survivors with clinical depression and anxiety disorders.
['Murphy|M J|MJ|0000-0001-8963-5747', 'Newby|J M|JM|', 'Butow|P|P|0000-0003-3562-6954', 'Loughnan|S A|SA|', 'Joubert|A E|AE|', 'Kirsten|L|L|', 'Allison|K|K|', 'Shaw|J|J|0000-0002-9543-7066', 'Shepherd|H L|HL|', 'Smith|J|J|', 'Andrews|G|G|']
D000328:Adult D001007:Anxiety D000073116:Cancer Survivors D015928:Cognitive Behavioral Therapy D003863:Depression D005260:Female D006801:Humans D000079382:Internet-Based Intervention D008297:Male D008875:Middle Aged
randomised controlled trial depression anxiety cancer Internet cognitive behavioural therapy oncology