Neutrophil-lymphocyte ratio at diagnosis is an independent prognostic factor in patients with nodular sclerosis Hodgkin lymphoma: results of a large multicenter study involving 990 patients.
Several studies have demonstrated the prognostic value of neutrophil-lymphocyte ratio (NLR) in patients with solid tumors and non-Hodgkin lymphoma. In contrast, there is only sparse data on its prognostic role in patients with classical Hodgkin lymphoma (cHL). The aim of our study was to establish whether NLR could serve as an independent prognostic factor in a cohort of 990 patients with nodular sclerosis (NS)-cHL. After analysis of the log hazard ratio (HR) as a function of NLR, we chose the value 6 as cutoff. Patients with NLR >6 had a worse progression-free survival and overall survival compared to those with NLR ≤6; 84% vs 75% and 92% vs 88%, at 5 years, with an HR of 1.65 and 1.82, respectively. Multivariate analysis showed that the risk remained high with HR 1.44 and HR 1.54 in progression-free survival and overall survival, respectively. In summary, our study shows that NLR is a robust and independent prognostic parameter in NS-cHL, both in early and advanced disease. It is inexpensive and simple to apply. Thus, we conclude that NLR, possibly in combination with the international prognostic score and absolute monocyte count, is a useful guide for physicians treating NS-cHL patients.
['Marcheselli|Raffaella|R|', 'Bari|Alessia|A|', 'Tadmor|Tamar|T|', 'Marcheselli|Luigi|L|', 'Cox|Maria Christina|MC|', 'Pozzi|Samantha|S|', 'Ferrari|Angela|A|', 'Baldini|Luca|L|', 'Gobbi|Paolo|P|', 'Aviv|Ariel|A|', 'Pugliese|Giuseppe|G|', 'Federico|Massimo|M|', 'Polliack|Aaron|A|', 'Sacchi|Stefano|S|']
D000293:Adolescent D000328:Adult D000368:Aged D015415:Biomarkers D003131:Combined Modality Therapy D005260:Female D006689:Hodgkin Disease D006801:Humans D053208:Kaplan-Meier Estimate D007958:Leukocyte Count D008214:Lymphocytes D008297:Male D008875:Middle Aged D009367:Neoplasm Staging D009504:Neutrophils D011379:Prognosis D016016:Proportional Hazards Models D012016:Reference Values D012189:Retrospective Studies D016896:Treatment Outcome D055815:Young Adult
neutrophil-lymphocyte ratio Hodgkin lymphoma lymphocyte neutrophil prognosis