Bifidobacterium pseudocatenulatum CECT 7765 supplementation improves inflammatory status in insulin-resistant obese children.
PURPOSE
The relationships between gut microbiota and obesity-related co-morbidities have been increasingly recognized. Low-grade inflammation may be the main factor in the pathogenesis of such disorders. We investigated the effect of the potential probiotic Bifidobacterium pseudocatenulatum CECT 7765 on cardiometabolic risk factors, inflammatory cytokines and gut microbiota composition in obese children with insulin resistance.


METHODS
The study included 48 obese children (10-15 years old) with insulin resistance. They received dietary advice and were assigned to take the capsules with or without probiotic (109-10 CFU) daily for 13 weeks. Clinical, biochemical and gut microbiome measurements were made at baseline and at the end of the intervention.


RESULTS
There was a significant improvement in body mass index in all children after the intervention, suggesting that weight changes are related to the dietary advice. A significant decrease in circulating high-sensitive C-reactive protein (P = 0.026) and monocyte chemoattractant protein-1 (P = 0.032) and an increase in high-density lipoprotein cholesterol (P = 0.035) and omentin-1 (P = 0.023) in children receiving probiotic supplementation were observed compared to the control group. Regarding gut microbiota, probiotic administration significantly increased the proportion of the Rikenellaceae family members, particularly of the Alistipes genus.


CONCLUSIONS
The beneficial effects of the intervention on inflammatory markers and lipid profile suggest that B. pseudocatenulatum CECT 7765 intake together with dietary recommendations can improve inflammatory status in children with obesity and insulin resistance. These effects are parallel to increases in bacterial groups associated with a lean phenotype. The modulation of gut microbiota with probiotic supplementation can be considered an effective tool to ameliorate some obesity-related disorders in children.
['Sanchis-Chordà|Jesús|J|', 'Del Pulgar|Eva M Gómez|EMG|', 'Carrasco-Luna|Joaquín|J|', 'Benítez-Páez|Alfonso|A|', 'Sanz|Yolanda|Y|', 'Codoñer-Franch|Pilar|P|http://orcid.org/0000-0002-1549-1573']
D000293:Adolescent D000070257:Bifidobacterium pseudocatenulatum D002648:Child D019587:Dietary Supplements D005260:Female D000069196:Gastrointestinal Microbiome D006801:Humans D007249:Inflammation D007333:Insulin Resistance D008297:Male D009765:Obesity D019936:Probiotics D011446:Prospective Studies
Bifidobacterium pseudocatenulatum Gut microbiota Probiotics Monocyte chemoattractant protein-1 Omentin-1 Children obesity