Why do peroxisomes associate with the cytoskeleton?
Attachment of peroxisomes to cytoskeleton and movement along microtubular filaments and actin cables are essential and highly regulated processes enabling metabolic efficiency, biogenesis, maintenance and inheritance of this dynamic cellular compartment. Several peroxisome-associated proteins have been identified, which mediate interaction with motor proteins, adaptor proteins or other constituents of the cytoskeleton. It appears that there is a species-specific complexity of protein-protein interactions required to control directional movement and arresting. An open question is why some proteins with a specific role in peroxisomal protein import have an additional function in the regulation of cytoskeleton binding and motility of peroxisomes.
['Neuhaus|Alexander|A|', 'Eggeling|Christian|C|', 'Erdmann|Ralf|R|', 'Schliebs|Wolfgang|W|']
D008841:Actin Cytoskeleton D001692:Biological Transport D005786:Gene Expression Regulation D006801:Humans D008565:Membrane Proteins D008870:Microtubules D018995:Myosin Heavy Chains D024701:Myosin Type V D001678:Organelle Biogenesis D000074401:Peroxins D020675:Peroxisomes D020033:Protein Isoforms D018160:Receptors, Cytoplasmic and Nuclear D012441:Saccharomyces cerevisiae D029701:Saccharomyces cerevisiae Proteins D015398:Signal Transduction
Cytoskeleton Motor proteins Actin filaments Microtubules Peroxins Peroxisome motility