Comparative prognostic relevance of breast intra-tumoral microvessel density evaluated by CD105 and CD146: A pilot study of 42 cases.
UNLABELLED
Angiogenesis is a key process for metastatic progression. While it has been established that the evaluation of breast tumoral microvessel density by CD105 marker is a potential prognostic parameter, its evaluation by CD146 marker has been poorly studied.


AIM
The purpose of this study was to compare the prognostic value of intra-tumoral microvessel density assayed by CD105 and CD146 in early breast cancer patients.


METHODS
42 women with breast infiltrative ductal carcinoma (I and II-stages) were retrospectively reviewed. Intra-tumoral microvessel density was immunohistochemically examined using antibodies anti-CD105 and CD146 in paraffin-embedded tissues, and their association with classical prognostic-markers, metastatic recurrence, metastasis-free survival and overall survival was analyzed.


RESULTS
High microvessel density assessed by CD146 was significantly associated with a higher risk of developing metastasis (p=0.0310) and a shorter metastasis-free survival (p=0.0197). In contrast, when we used the CD105-antibody, we did not find any significant association. Finally, CD146 showed to be an independent predictive indicator for metastasis-free survival (p=0.0055).


CONCLUSION
Our data suggest that the intra-tumoral microvessel density evaluated by CD146 may be a more suitable predictor of metastatic development than that evaluated by CD105 in early breast cancer.
['Martinez|Leandro Marcelo|LM|', 'Labovsky|Vivian|V|', 'Calcagno|María de Luján|Mde L|', 'Davies|Kevin Mauro|KM|', 'Rivello|Hernán Garcia|HG|', 'Wernicke|Alejandra|A|', 'Calvo|Juan Carlos|JC|', 'Chasseing|Norma Alejandra|NA|']
D000328:Adult D014408:Biomarkers, Tumor D001943:Breast Neoplasms D051929:CD146 Antigen D018270:Carcinoma, Ductal, Breast D000071063:Endoglin D005260:Female D006801:Humans D007150:Immunohistochemistry D053208:Kaplan-Meier Estimate D008875:Middle Aged D009389:Neovascularization, Pathologic D010865:Pilot Projects D011379:Prognosis D016016:Proportional Hazards Models D012189:Retrospective Studies
Intra-tumoral microvessel density CD105 CD146 Breast cancer Prognostic significance