Protective Effect of Salicornia europaea Extracts on High Salt Intake-Induced Vascular Dysfunction and Hypertension.
High salt intake causes and aggravates arterial hypertension and vascular dysfunction. We investigated the effect of Salicornia europaea extracts (SE) on vascular function and blood pressure. SE constituents were analyzed using high performance liquid chromatography, and SE's effect on vascular function was evaluated in isolated porcine coronary arteries. SE's vascular protective effect was also evaluated in vivo using normotensive and spontaneous hypertensive rats (SHRs). SE mainly contained sodium chloride (55.6%), 5-(hydroxymethyl)furfural, p-coumaric acid, and trans-ferulic acid. High sodium (160 mmol/L) induced vascular dysfunction; however, SE containing the same quantity of sodium did not cause vascular dysfunction. Among the compounds in SE, trans-ferulic acid accounts for the vascular protective effect. Normotensive rats fed a high-salt diet showed significantly increased systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP), which decreased significantly in the SE-treated groups. In SHRs, high edible salt intake significantly increased SBP, DBP, and MAP, but SE intake was associated with a significantly lower MAP. Thus, SE did not induce vascular dysfunction, and trans-ferulic acid might be at least partly responsible for the vasoprotective effect of SE. Taken together, SE could be used as an alternative to purified salt to prevent and ameliorate hypertension.
['Panth|Nisha|N|', 'Park|Sin-Hee|SH|', 'Kim|Hyun Jung|HJ|', 'Kim|Deuk-Hoi|DH|', 'Oak|Min-Ho|MH|']
D000818:Animals D001794:Blood Pressure D001835:Body Weight D002318:Cardiovascular Diseases D019663:Chenopodiaceae D002851:Chromatography, High Pressure Liquid D006973:Hypertension D008297:Male D010936:Plant Extracts D051381:Rats D011918:Rats, Inbred SHR D017207:Rats, Sprague-Dawley D017673:Sodium Chloride, Dietary D013552:Swine
Salicornia europaea vascular dysfunction hypertension blood pressure