Toxic epidermal necrolysis due to therapy with cyclophosphamide and mesna. A case report of a patient with seronegative rheumatoid arthritis and rheumatoid vasculitis.
Rheumatoid vasculitis usually occurs on the background of seropositive rheumatoid arthritis, although in rare cases the patients can be seronegative. We report a woman with seronegative rheumatoid arthritis with rheumatoid vasculitis who developed toxic epidermal necrolysis involving most of her body surface area, while on therapy with intravenous cyclophosphamide and mesna. After withdrawal of suspected offending agents, administration of intravenous immunoglobulin, and supportive therapy, she had a favorable outcome. Such an occurrence is rare and serves to educate about a potentially life-threatening adverse event associated with a commonly used immunosuppressive agent.
['Chowdhury|A C|AC|', 'Misra|D P|DP|', 'Patro|P S|PS|', 'Agarwal|V|V|']
D018501:Antirheumatic Agents D001172:Arthritis, Rheumatoid D003520:Cyclophosphamide D006801:Humans D015080:Mesna D020011:Protective Agents D056653:Rheumatoid Vasculitis D013262:Stevens-Johnson Syndrome D016896:Treatment Outcome
Rheumatoid vasculitis Immunoglobulin Immunosuppressive agents Adverse drug reaction Seronegative rheumatoid vasculitis