Screening for Zika virus in deceased organ donors in Florida.
Zika virus (ZIKV) cases have been detected across the United States (US) and locally acquired cases have been reported in Florida. Currently, there are no ZIKV screening guidelines and no data on the incidence among organ donors in the US. This retrospective study was conducted at Jackson Memorial-Miami Transplant Institute. Positive ZIKV tests in local deceased organ donors were investigated from 6/2016 to 1/2017. We evaluated demographics and risk factors for ZIKV infection among organ donors and transplant outcomes among recipients of donors with positive ZIKV testing. One hundred forty-two donors were analyzed. Ten percent had traveled to ZIKV-endemic countries and 19% had outdoor occupations. Only 3% had positive ZIKV IGG. None had a positive ZIKV IGM or PCR. ZIKV-positive donors were more likely to have traveled to ZIKV-endemic countries (50% vs. 9%, P = .05). The kidneys from a ZIKV-positive donor were transplanted in our hospital with no 6-month rejection, graft failure, or death in the recipients. Our study demonstrated a low prevalence of ZIKV among deceased donors in our community. Despite local ZIKV transmission, ZIKV was more common in donors who traveled to ZIKV-endemic countries. This cohort demonstrated excellent outcomes in recipients of ZIKV IGG-positive donors. However, larger studies are needed.
['Simkins|J|J|', 'Anjan|S|S|', 'Morillas-Rodriguez|J A|JA|', 'Greissman|S R|SR|', 'Abbo|L M|LM|', 'Camargo|J F|JF|', 'Ruiz|P|P|', 'Vianna|R|R|', 'Guerra|G|G|', 'Salama|S|S|', 'Morris|M I|MI|']
D000328:Adult D001782:Blood Donors D046148:Donor Selection D005260:Female D005431:Florida D005500:Follow-Up Studies D006801:Humans D008297:Male D008403:Mass Screening D008875:Middle Aged D012367:RNA, Viral D012189:Retrospective Studies D000071244:Zika Virus D000071243:Zika Virus Infection
clinical research/practice donors and donation: donor evaluation epidemiology infection and infectious agents - viral infectious disease