Efficient deprotection of F-BODIPY derivatives: removal of BF2 using Brønsted acids.
The effective and efficient removal of the BF2 moiety from F-BODIPY derivatives has been achieved using two common Brønsted acids; treatment with trifluoroacetic acid (TFA) or methanolic hydrogen chloride (HCl) followed by work-up with Ambersep(®) 900 resin (hydroxide form) effects this conversion in near-quantitative yields. Compared to existing methods, these conditions are relatively mild and operationally simple, requiring only reaction at room temperature for six hours (TFA) or overnight (HCl).
['Yu|Mingfeng|M|', 'Wong|Joseph K-H|JK|', 'Tang|Cyril|C|', 'Turner|Peter|P|', 'Todd|Matthew H|MH|', 'Rutledge|Peter J|PJ|']
F-BODIPYs Brønsted acids click chemistry deboration dipyrrins