Exploiting the bad eating habits of Ras-driven cancers.
Oncogenic Ras promotes glucose fermentation and glutamine use to supply central carbon metabolism, but how and why have only emerged recently. Ras-mediated metabolic reprogramming generates building blocks for growth and promotes antioxidant defense. To fuel metabolic pathways, Ras scavenges extracellular proteins and lipids. To bolster metabolism and mitigate stress, Ras activates cellular self-cannibalization and recycling of proteins and organelles by autophagy. Targeting these distinct features of Ras-driven cancers provides novel approaches to cancer therapy.
['White|Eileen|E|']
D000818:Animals D001343:Autophagy D005947:Glucose D005973:Glutamine D006801:Humans D050356:Lipid Metabolism D053858:Metabolic Networks and Pathways D009369:Neoplasms D011506:Proteins D018631:ras Proteins
Ras glutamine scavenging autophagy cancer metabolism macropinocytosis