Familial multiple sclerosis in a Brazilian sample: Is HLA-DR15 involved in susceptibility to the disease?
BACKGROUND
The HLA-DR15 extended haplotype HLA-DRB1*15:01-DQA1*01:02-DQB1*06:02 comprises the strongest genetic risk factor for multiple sclerosis (MS). The aim of this work was to investigate whether HLA-DR15 alleles were significantly associated with the susceptibility to MS familial forms (MSf) in an admixed Brazilian population.


METHODS
Association analyses between DR15 and the clinical and demographic variables were made.


RESULTS
We have genotyped 25 familial cases. The DR15 was detected in 11/25 (44%) of them and in none of controls (P < .00001). DR15 was significantly associated to a foreign ancestor background (P = .029) and later age of onset (P = .018).
['da Silva Bernardes|Melina|M|', 'Antão Paiva|Carmen Lucia|CL|', 'Ribeiro Paradela|Eduardo|E|', 'Papais Alvarenga|Marcos|M|', 'Ferreira Pereira|Fernanda|F|', 'Vasconcelos|Claudia Cristina|CC|', 'Papais Alvarenga|Regina Maria|RM|']
D000328:Adult D001938:Brazil D003430:Cross-Sectional Studies D005260:Female D020022:Genetic Predisposition to Disease D059810:HLA-DR Serological Subtypes D006801:Humans D008297:Male D008875:Middle Aged D009103:Multiple Sclerosis
Familial Multiple sclerosis Brazilians HLA-DR15 Susceptibility HLA-DRB1