Novel daily disposable therapeutic contact lenses based on chitosan and regenerated silk fibroin for the ophthalmic delivery of diclofenac sodium.
The aim of this study was to investigate the possibility of chitosan and regenerated silk fibroin (CS/RSF) blended films as novel biomaterials for daily disposable therapeutic contact lenses based ophthalmic drug delivery system. Diclofenac sodium (DS), a hydrophilic anti-inflammatory agent, was loaded into CS/RSF films by a soaking method. The best conditions of DS loading manifested the loading time of 2 h and pH 6.5 of drug solution. The drug loading capacity and the drug release profile could be controlled by varying the film RSF content. With increasing the film RSF content from 0 to 30%, the amount of loaded DS increased from 12 to 23 µg. Furthermore, the prolong drug released within therapeutic level was obtained with increasing the film RSF content. Consequently, a fast released characteristic within a therapeutic level up to 3 h was observed with the 100CS/0RSF film. On the other hand, the 70CS/30RSF film demonstrated a significant prolonged drug release within therapeutic level up to 11 h. In conclusion, the CS/RSF films are promising as novel biomaterials for daily disposable therapeutic contact lenses-based ophthalmic delivery.
['Jeencham|Rachasit|R|', 'Sutheerawattananonda|Manote|M|', 'Rungchang|Saowaluk|S|', 'Tiyaboonchai|Waree|W|http://orcid.org/0000-0002-8570-0465']
D000894:Anti-Inflammatory Agents, Non-Steroidal D001672:Biocompatible Materials D048271:Chitosan D003263:Contact Lenses, Hydrophilic D003692:Delayed-Action Preparations D004008:Diclofenac D004209:Disposable Equipment D016503:Drug Delivery Systems D005349:Fibroins D006801:Humans
Contact lenses chitosan regenerated silk fibroin diclofenac sodium drug release