Silicene Quantum Capacitance Dependent Frequency Readout to a Label-Free Detection of DNA Hybridization- A Simulation Analysis.
The use of deoxyribonucleic acid (DNA) hybridization to detect disease-related gene expression is a valuable diagnostic tool. An ion-sensitive field-effect transistor (ISFET) with a graphene layer has been utilized for detecting DNA hybridization. Silicene is a two-dimensional silicon allotrope with structural properties similar to graphene. Thus, it has recently experienced intensive scientific research interest due to its unique electrical, mechanical, and sensing characteristics. In this paper, we proposed an ISFET structure with silicene and electrolyte layers for the label-free detection of DNA hybridization. When DNA hybridization occurs, it changes the ion concentration in the surface layer of the silicene and the pH level of the electrolyte solution. The process also changes the quantum capacitance of the silicene layer and the electrical properties of the ISFET device. The quantum capacitance and the corresponding resonant frequency readout of the silicene and graphene are compared. The performance evaluation found that the changes in quantum capacitance, resonant frequency, and tuning ratio indicate that the sensitivity of silicene is much more effective than graphene.
['Rahman|Md Sazzadur|MS|', 'Naima|Rokaia Laizu|RL|', 'Shetu|Khatuna Jannatun|KJ|', 'Hossain|Md Mahabub|MM|0000-0003-2840-5352', 'Kaiser|M Shamim|MS|0000-0002-4604-5461', 'Hosen|A S M Sanwar|ASMS|0000-0003-0934-0995', 'Sarker|Md Abdul Latif|MAL|', 'Ooi|Kelvin J A|KJA|0000-0002-9172-1705']
D015374:Biosensing Techniques D003198:Computer Simulation D004247:DNA D015342:DNA Probes D025802:Electric Capacitance D006108:Graphite D012825:Silicon D014173:Transistors, Electronic
quantum capacitance ISFETs resonant frequency biosensor pH detection