Chelation versus Non-Chelation Control in the Stereoselective Alkenyl sp2 C-H Bond Functionalization Reaction.
A hydroxy group chelation-assisted stereospecific oxidative cross-coupling reaction between alkenes was developed under mild reaction conditions. In the presence of palladium catalyst, the alkenes tethered with hydroxy functionality can couple efficiently with electron-deficient alkenes to form the corresponding multi-substituted olefin products. The hydroxy group on the substrate could play dual roles in reaction, acting as the directing group for alkenyl C-H bond activation and controlling the stereoselectivity of the products.
['Liang|Qiu-Ju|QJ|', 'Yang|Chao|C|', 'Meng|Fei-Fan|FF|', 'Jiang|Bing|B|', 'Xu|Yun-He|YH|', 'Loh|Teck-Peng|TP|']
alkenylation cross-coupling palladium C−H activation