Aspergillus meningitis in a patient with chronic lymphocytic leukemia.
Central nervous system aspergillosis is relatively rare and difficult to diagnose. Here, we report a case of 90-year-old man with chronic lymphocytic leukemia who presented with a month-long gradually worsening headache followed by 3 days of low-grade fever associated with altered mental status. Aspergillus meningitis diagnosed using Aspergillus galactomannan antigen in the cerebrospinal fluid and treated with voriconazole. Delayed diagnosis and treatment of Aspergillus meningitis is typically associated with high mortality; therefore, it is imperative to include this disease in the differential diagnoses of subacute meningitis.
['Matsuo|Takahiro|T|', 'Mori|Nobuyoshi|N|', 'Sakurai|Aki|A|', 'Furukawa|Keiichi|K|']
D000369:Aged, 80 and over D000935:Antifungal Agents D000946:Antigens, Fungal D001228:Aspergillosis D003937:Diagnosis, Differential D005690:Galactose D006801:Humans D015451:Leukemia, Lymphocytic, Chronic, B-Cell D008297:Male D008351:Mannans D016921:Meningitis, Fungal D065819:Voriconazole
Aspergillus meningitis Galactomannan CNS aspergillosis