Prognostic factors in patients with penile cancer after surgical management.
PURPOSE
To examine the possible prognostic factors in patients with penile cancer after surgical management and to identify the independent predictive factors of the prognosis.


MATERIALS AND METHODS
Clinical data of 135 patients with penile cancer who underwent surgical management in two medical centers were collected. Follow-up data were available for 103 patients. Possible prognostic factors including patient's age; smoking or not; course of disease; phimosis or not; type of surgery; tumor stage; nodal stage; tumor grade and pathological lymph nodes metastasis were retrospectively analyzed by univariate and multivariate analyses with Cox regression.


RESULTS
Five-year cancer-specific survival (CSS) and 1-year CSS were 88.5 and 98.1%, respectively. Univariate Cox analysis revealed that nodal stage and pathological lymph nodes metastasis were significant prognostic factors. Multivariate Cox analysis revealed pathological lymph nodes metastasis was the independent predictive factor of the prognosis.


CONCLUSION
Pathological lymph nodes metastasis is the independent predictive factor worsening the prognosis in patients with penile cancer.
['Wen|Shuguang|S|', 'Ren|Wenbiao|W|', 'Xue|Bichen|B|', 'Fan|Yi|Y|', 'Jiang|Yongjun|Y|', 'Zeng|Chunming|C|', 'Li|Yujia|Y|', 'Zu|Xiongbing|X|']
D000368:Aged D002294:Carcinoma, Squamous Cell D006801:Humans D008197:Lymph Node Excision D008198:Lymph Nodes D008207:Lymphatic Metastasis D008297:Male D008875:Middle Aged D015999:Multivariate Analysis D009367:Neoplasm Staging D059351:Organ Sparing Treatments D010412:Penile Neoplasms D010413:Penis D011379:Prognosis D016016:Proportional Hazards Models D012189:Retrospective Studies D015996:Survival Rate
Penile cancer Prognosis Lymph nodes metastasis