A new furanosteroid from Talaromyces sp. lgt-4, a fungal endophyte isolated from Tripterygium wilfordii.
Wortmannolol (1), a new furanosteroid, along with five known compounds, wortmannolone (2), ergosterol (3), p-hydroxyphenyl ethanol (4), trans-6-dodecene (5), (2Z, 4E) -5-(8-hydroxy-1,5-dimethyl-3-oxo-6-oxabicyclo [3.2.1] octan-8-yl) -3-methylpenta-2,4-dienoic acid (6) were isolated from a fungal endophyte Talaromyces sp. lgt-4. Their structures were elucidated by IR, MS, 1D and 2D NMR spectra. Compound 1 show weak monoamine oxidase inhibitory activity.
['Zhi|Kang-Kang|KK|', 'Yang|Zhong-Duo|ZD|', 'Zhou|Shuang-Yan|SY|', 'Yao|Xiao-Jun|XJ|', 'Li|Shuo|S|', 'Zhang|Fei|F|']
D000473:Alkanes D004353:Drug Evaluation, Preclinical D060026:Endophytes D004875:Ergosterol D009682:Magnetic Resonance Spectroscopy D015394:Molecular Structure D008996:Monoamine Oxidase Inhibitors D010626:Phenylethyl Alcohol D013261:Sterols D032901:Talaromyces D029757:Tripterygium
Furanosteroid Talaromyces endophyte Tripterygium wilfordii