Impact of anatomic site of distant metastasis on survival in salivary gland cancers.
BACKGROUND
As exemplified in patients with adenoid cystic carcinoma (ACC), metastatic salivary gland cancers display heterogenous behavior. Although anatomic site of metastasis has been suggested to be prognostic for survival in this population, this is not adequately characterized in the current literature.


METHODS
Using the National Cancer Database (NCDB), patients with newly diagnosed metastatic salivary gland cancers with distant metastasis to a single organ were identified.


RESULTS
Eight hundred and fifty-eight patients (n = 284 bone-only, n = 322 lung-only, n = 252 other-site-only) were identified. Anatomic site of distant metastasis was not associated with survival in the cohort as a whole; however, on pre-planned subgroup analysis, lung-only metastasis, relative to bone-only metastasis, was the only factor associated with improved survival in patients with ACC (HR: 0.52, 95%CI: 0.30-0.93, p = 0.029).


CONCLUSIONS
Anatomic site of metastasis is strongly associated with survival in patients with metastatic ACC and should be considered in future studies aiming to optimize therapy in this population.
['Turchan|William Tyler|WT|0000-0001-9537-6980', 'Korpics|Mark C|MC|', 'Rooney|Michael|M|', 'Koshy|Matthew|M|', 'Spiotto|Michael T|MT|0000-0003-4484-462X']
D001859:Bone Neoplasms D003528:Carcinoma, Adenoid Cystic D006801:Humans D008175:Lung Neoplasms D011379:Prognosis D012189:Retrospective Studies D012468:Salivary Gland Neoplasms
metastasis adenoid cystic carcinoma head and neck neoplasms salivary gland neoplasms