LINC00173 promotes the apoptosis of hypertrophic scar fibroblasts through increasing β-catenin expression.
Previous studies have demonstrated the involvement of long intergenic nonprotein coding RNA 173 (LINC00173) in several pathological disorders. However, the function of LINC00173 in the hypertrophic scar is not well understood. This study confirmed that the two transcript variants of TSV1 and TSV2 were both upregulated in hypertrophic scar fibroblasts. The overexpression of TSV1 or TSV2 promoted the apoptosis of fibroblasts, whereas the overexpression of TSV2 inhibited the proliferation of fibroblasts. RNA-sequencing (RNA-seq), Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis, and gene set enrichment analysis (GSEA) showed that phosphatidylinositol 3-kinase (PI3K)/Akt and Mitogen-activated protein kinases (MAPK) signaling might be involved in the role of LINC00173 in hypertrophic scar pathogenesis. Furthermore, the protein expression of β-catenin was upregulated in the TSV1 or TSV2 overexpression group. Overall, the study demonstrated that LINC00173 promoted the apoptosis of fibroblasts through increasing β-catenin expression, suggesting that LINC00173 might be a new target for hypertrophic scar treatment.
['Li|Qian|Q|', 'Chen|Xin|X|', 'Chen|Ling|L|', 'Yan|Hui|H|', 'Li|Jun|J|http://orcid.org/0000-0002-5419-2656']
D017209:Apoptosis D016022:Case-Control Studies D049109:Cell Proliferation D002648:Child D002675:Child, Preschool D017439:Cicatrix, Hypertrophic D005260:Female D005347:Fibroblasts D005786:Gene Expression Regulation D006801:Humans D008297:Male D061251:Primary Cell Culture D062085:RNA, Long Noncoding D017423:Sequence Analysis, RNA D015398:Signal Transduction D015854:Up-Regulation D051176:beta Catenin
LINC00173 Apoptosis Hypertrophic scar β-catenin