Phase I, multicenter, dose-escalation study of avadomide in adult Japanese patients with advanced malignancies.
Non-Hodgkin lymphoma (NHL) treated with chemoimmunotherapy has limited efficacy in some patients, resulting in relapsed or refractory disease. Avadomide (CC-122) is a novel cereblon-binding agent that exhibits antilymphoma and immune-modulation activities with a biological profile distinct from similar agents, such as lenalidomide. This phase I multicenter study evaluated avadomide in Japanese patients with advanced solid tumors or NHL. Fourteen patients with NHL and one with a solid tumor (esophageal carcinoma), were enrolled in four dose-escalation cohorts using a 3 + 3 design. Primary endpoints included safety, dose-limiting toxicities (DLT), maximum-tolerated dose and/or recommended phase II dose (RP2D), and pharmacokinetics. Secondary endpoints included overall response rate (ORR) and duration of response. One patient with NHL experienced DLT, which included face edema, pharyngeal edema, and tumor flare (all grade 1) that led to a dose reduction. Eleven patients had grade ≥3 treatment-emergent adverse events, most frequently decreased neutrophil count (33%) and decreased lymphocyte count (20%). The ORR in patients with NHL (n = 13) was 54%, including four complete and three partial responses. The best response for the solid tumor patient was progressive disease. Avadomide dose intensity was consistent across cohorts, and the 3-mg dose given five consecutive days/week was established as the RP2D. This phase I study identified a tolerable dose of avadomide, with an acceptable toxicity profile and clinically meaningful efficacy in Japanese patients with previously treated NHL.
['Hatake|Kiyohiko|K|https://orcid.org/0000-0002-4153-4987', 'Chou|Takaaki|T|', 'Doi|Toshihiko|T|', 'Terui|Yasuhito|Y|', 'Kato|Harumi|H|', 'Hirose|Takayuki|T|', 'Seo|Sachiko|S|', 'Pourdehnad|Michael|M|', 'Ogaki|Yumi|Y|', 'Fujimoto|Hiroshi|H|', 'Hagner|Patrick R|PR|', 'Yamamoto|Kazuhito|K|']
D000368:Aged D000970:Antineoplastic Agents D004305:Dose-Response Relationship, Drug D004938:Esophageal Neoplasms D005260:Female D006801:Humans D007564:Japan D008228:Lymphoma, Non-Hodgkin D008297:Male D020714:Maximum Tolerated Dose D008875:Middle Aged D010881:Piperidones D052999:Quinazolinones
phase I dose-escalation avadomide non-Hodgkin lymphoma CC-122 cereblon