Evaluating -238 G>A Polymorphism Association in TNF-α Gene with Metabolic Parameters and Nutritional Intakes Among the Iranian NAFLD Patients.
Different studies have shown that -238 G>A polymorphism in promoter region of tumor necrosis factor alpha (TNF-α) gene is associated with increased risk of non-alcoholic fatty liver disease (NAFLD). The current study investigates the association between metabolic parameters and nutritional intakes with -238 G>A of TNF-α promoter gene polymorphism among the Iranian patients with NAFLD. In this study, 75 patients with NAFLD and 76 individuals as control were enrolled. Dietary intakes were assessed using a semi-quantitative food-frequency questionnaire. Body mass index and waist to hip ratio were calculated. Biochemical assays were measured after 12 h fasting. -238 G>A Polymorphism of TNF-α gene was determined by using sequencing method. We observed no significant difference in frequency of different genotypes of this polymorphism between NAFLD and control groups (P > 0.05). Among biochemical parameters, TAC showed significant decrease in NAFLD patients with GG genotype when compared to controls (P = 0.001). The comparison of macro and micronutrient intakes between groups according to genotypes showed no statistically significant difference (P > 0.05). Although the data were not statistically significant, further studies with larger sample size are needed to determine the effect of dietary compounds in NAFLD.
['Mohseni|F|F|', 'Rashvand|Z|Z|', 'Najafipour|R|R|', 'Hadizadeh|Sh|Sh|', 'Moghbelinejad|S|S|']
D000328:Adult D000975:Antioxidants D004435:Eating D005260:Female D005787:Gene Frequency D056726:Genetic Association Studies D020022:Genetic Predisposition to Disease D006801:Humans D007492:Iran D008297:Male D008875:Middle Aged D065626:Non-alcoholic Fatty Liver Disease D020641:Polymorphism, Single Nucleotide D011401:Promoter Regions, Genetic D014409:Tumor Necrosis Factor-alpha D044465:Whites D055815:Young Adult
TNF-α gene Nutrition Non-alcoholic fatty liver disease (NAFLD) Biochemical parameters −238 G>A polymorphism