Antimicrobials and renal failure in neutropenic patients.
Antimicrobial treatment is often indicated to neutropenic patients. Although renal failure is a common complication of many antibiotics, no information could be found in the literature defining which are the best screening criteria for detecting renal injury. In this paper, the authors aim to assess the progress to renal failure in neutropenic patients on antimicrobial use and to compare different diagnostic criteria of renal failure in association to antimicrobial agents used. This is a cohort study conducted from February to August 2006 at the Hospital das Clínicas of the Universidade Federal de Minas Gerais, which included patients with neutropenia and antimicrobial therapy for the treatment of Healthcare Associated Infections notified by the Hospital Infection Control Committee. Renal injury has ensued in 25% of patients and no statistical difference between distinct criteria for renal injury was observed. Association of greater number of antimicrobials was associated with renal impairment. Time required for renal injury was independent of the antimicrobial regimen used, but mortality among patients with renal injury was higher when compared to those who had preserved renal function.
['França|Monique Sedlmaier|MS|', 'Lima|Stella Sala Soares|SS|', 'Duclou|Caroline Naback|CN|', 'Goulart|Eugênio Marcos Andrade|EM|', 'Romanelli|Roberta Maia de Castro|RM|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D000900:Anti-Bacterial Agents D002648:Child D002675:Child, Preschool D015331:Cohort Studies D005260:Female D019337:Hematologic Neoplasms D006801:Humans D008297:Male D008875:Middle Aged D009503:Neutropenia D051437:Renal Insufficiency D016896:Treatment Outcome D055815:Young Adult
Antimicrobial agents Neutropenia Renal insufficiency