Synthesis and characterization of gold nanoparticles from aqueous leaf extract of Alternanthera sessilis and its anticancer activity on cervical cancer cells (HeLa).
Cervical cancer is the third most common highest mortality in women worldwide. The use of standard chemotherapeutic drugs against cervical cancer patients received several side effects. Therefore, we focused phytoconsituents-mediated synthesis of gold nanoparticles (AuNPs) considered as greatest attention in the treatment of cervical cancer. In this present study, we reported that green synthesis of AuNPs by using with Alternanthera Sessilis aqueous extract. Synthesis of AuNPs were characterized by UV visible spectroscopy, energy dispersive X-ray (EDX), selected area diffraction pattern (SAED), Fourier transform infrared spectroscopy (FTIR), high-resolution transmission electron microscopy (HR-TEM) and atomic force microscope. Synthesized AuNPs confirmed by the UV absorption maximum at 535 and crystal structure of gold AuNPs was further confirmed by EDX and SAED. TEM and atomic force microscopy images show the size and morphological distribution of nanoparticles. FTIR analysis was confirmed the hydroxyl groups, amine and alkaline groups of biomolecules are present in the AuNPs. Moreover, AuNPs induce cytotoxicity in cervical cancer cells and also induce apoptosis through modulating intrinsic apoptotic mechanisms in cervical cancer cells. This green synthesis of AuNPs from Alternanthera sessilis approach was easy, large scaled up and eco-friendly.
['Qian|Linhua|L|', 'Su|Weihua|W|', 'Wang|Yan|Y|', 'Dang|Minyan|M|', 'Zhang|Wenzhi|W|', 'Wang|Changlin|C|']
D027703:Amaranthaceae D000970:Antineoplastic Agents D017209:Apoptosis D060326:Chemistry Techniques, Synthetic D005260:Female D015972:Gene Expression Regulation, Neoplastic D006046:Gold D055772:Green Chemistry Technology D006367:HeLa Cells D006801:Humans D053768:Metal Nanoparticles D010316:Particle Size D010936:Plant Extracts D018515:Plant Leaves D002583:Uterine Cervical Neoplasms D014867:Water
gold nanoparticles Cervical cancer apoptosis