Serum soluble toll-like receptor 2: a novel biomarker for systemic lupus erythematosus disease activity and lupus-related cardiovascular dysfunction.
AIM
To assess the serum levels of soluble toll-like receptor (sTLR2) as an endogenous negative regulator of TLR2 signaling in systemic lupus erythematosus (SLE) patients, to investigate the correlation between sTLR2 and SLE disease activity index (SELDAI), SLE-related cardiovascular risk factors and ventricular dysfunction and to evaluate the effect of different therapeutic regimens on serum sTLR2 levels.


METHODS
Ninety-six SLE patients, along with 30 healthy controls, were enrolled in the study. Echocardiography measurements were performed. Serum levels of (sTLR2) were measured using enzyme-linked immunosorbent assay (ELISA). Serum lipid profiles, uric acid and creatinine were also detected.


RESULTS
Mean serum levels of sTLR2 in SLE patients was 3.98 ± 4.4 ng/mL, which was significantly decreased as compared with that of the control group (11.3 ± 4.9 ng/mL; P < 0.0001). sTLR2 was negatively correlated with SELDAI, low-density lipoprotein (LDL) and left ventricular diastolic dysfunction. sTLR2 levels were increased in patients receiving hydroxychloroquine, statins and corticosteroids.


CONCLUSION
Serum sTLR2 can attenuate disease activity and negatively impact left ventricular diastolic dysfunction and hypercholersterelemia in SLE patients. Statins, corticosteroids and chloroquine increase sTLR2 levels.
['Houssen|Maha E|ME|', 'El-Mahdy|Rasha H|RH|', 'Shahin|Dina A|DA|']
D000305:Adrenal Cortex Hormones D000328:Adult D018501:Antirheumatic Agents D015415:Biomarkers D016022:Case-Control Studies D003404:Creatinine D003430:Cross-Sectional Studies D003971:Diastole D015536:Down-Regulation D015150:Echocardiography, Doppler D004797:Enzyme-Linked Immunosorbent Assay D005260:Female D006801:Humans D006886:Hydroxychloroquine D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors D006937:Hypercholesterolemia D008055:Lipids D008180:Lupus Erythematosus, Systemic D008297:Male D051195:Toll-Like Receptor 2 D014527:Uric Acid D018487:Ventricular Dysfunction, Left D016277:Ventricular Function, Left D055815:Young Adult
systemic lupus erythematosus TLR2 signaling (sTLR2) lupus-related cardiovascular risk factors