Modulation of tolerogenic dendritic cells and autoimmunity.
A key function of dendritic cells (DCs) is to induce either immune tolerance or immune activation. Many new DC subsets are being recognized, and it is now clear that each DC subset has a specialized function. For example, different DC subsets may express different cell surface molecules and respond differently to activation by secretion of a unique cytokine profile. Apart from intrinsic differences among DC subsets, various immune modulators in the microenvironment may influence DC function; inappropriate DC function is closely related to the development of immune disorders. The most exciting recent advance in DC biology is appreciation of human DC subsets. In this review, we discuss functionally different mouse and human DC subsets both in lymphoid organs and non-lymphoid organs, the molecules that regulate DC function, and the emerging understanding of the contribution of DCs to autoimmune diseases.
['Kim|Sun Jung|SJ|', 'Diamond|Betty|B|']
D000818:Animals D015551:Autoimmunity D001854:Bone Marrow Cells D002454:Cell Differentiation D016207:Cytokines D003713:Dendritic Cells D006801:Humans D007108:Immune Tolerance D018448:Models, Immunological D014157:Transcription Factors
Tolerogenic dendritic cells Dendritic cells Autoimmunity Tissue-resident dendritic cells