β-T594M epithelial sodium channel gene polymorphism and essential hypertension in individuals of Indo-Aryan ancestry in Northern India.
BACKGROUND
The T594M variant of the β-subunit of the sodium epithelial channel (ENaC) gene may contribute to hypertension in individuals of Indo-Aryan origin.


METHODS
Present study was performed to assess the role of the ENaC gene variant as an independent risk factor for hypertension in subjects of Indo-Aryan ancestry. A total of 150 patients of recently detected essential hypertension and 150 matched controls were genotyped for the T594M polymorphism of the ENaC gene by PCR-RFLP method.


RESULTS
β-T594M mutation was found to be non-polymorphic. There was major genotype call in both the groups i.e. cases and controls. Other phenotypic parameters like age, sex and body mass index were also similar among hypertensive patients and controls (P > 0.05). Hypertensive patients had significantly higher total cholesterol and triglycerides compared with controls (P < 0.0001).


CONCLUSION
These results do not suggest an important role for the T594M variant of the ENaC gene contributing to either the development or severity of hypertension in subjects of Indo-Aryan ancestry.
['Gupta|Mohit D|MD|', 'Girish|M P|MP|', 'Sikdar|Sunandan|S|', 'Ahuja|Ramandeep|R|', 'Shah|Dhaval|D|', 'Kumar|Rahul|R|', 'Rain|Manjari|M|', 'Nejatizadeh|Azim|A|', 'Tyagi|Sanjay|S|', 'Pasha|Qadar|Q|']
D000328:Adult D016022:Case-Control Studies D053503:Epithelial Sodium Channels D000075222:Essential Hypertension D005260:Female D020022:Genetic Predisposition to Disease D005838:Genotype D006801:Humans D006973:Hypertension D007194:India D008055:Lipids D008297:Male D008875:Middle Aged D009154:Mutation D010641:Phenotype D010865:Pilot Projects D016133:Polymerase Chain Reaction D011110:Polymorphism, Genetic D012150:Polymorphism, Restriction Fragment Length D012307:Risk Factors
Polymorphism Essential hypertension Sodium epithelial channel Association study