Critical Role of IL-8 Targeting in Gliomas.
BACKGROUND
Glioma is a heterogeneous, highly complicated central nervous system (CNS) tumor with uncertain mechanism of initiation and progression, resulting in an unfavorable outcome. An extended network of cytokines is recognized as a major regulator of glioma pathogenesis, either promoting or inhibiting glioma progression based on their type and specificity. Interleukin-8 (IL-8) has been revealed as a critical regulator of CNS function and development with participation in many CNS disorders including gliomas.


OBJECTIVE
The aim of the present review is to address the role of IL-8 in glioma pathogenesis focusing on the implicated molecular pathways as well as on its potential targeting for glioma therapy.


METHODS AND RESULTS
PubMed-Medline, SCOPUS, and Google Scholar databases were searched for pre-clinical and clinical studies related to IL-8 implication in gliomagenesis and IL-8 targeting strategies for gliomas. Literature data indicate that IL-8 participates in glioma angiogenesis and cell migration and it can serve as a potential biomarker, for early diagnosis, follow-up and response to therapy.


CONCLUSION
Several promising approaches that target directly or indirectly IL-8 effects in gliomas are currently in progress while more-in-depth studies are needed to validate its biomarker role and elucidate the underlying molecular mechanisms.
['Kosmopoulos|Marinos|M|', 'Christofides|Anthos|A|', 'Drekolias|Dimitrios|D|', 'Zavras|Phaedon D|PD|', 'Gargalionis|Antonios N|AN|', 'Piperi|Christina|C|']
D000818:Animals D000970:Antineoplastic Agents D014408:Biomarkers, Tumor D063646:Carcinogenesis D002465:Cell Movement D015536:Down-Regulation D005910:Glioma D006801:Humans D016209:Interleukin-8 D009389:Neovascularization, Pathologic
IL-8 Glioma cytokines therapy. angiogenesis migration CNS tumor