Haematological indices as predictors of atrial fibrillation following isolated coronary artery bypass grafting, valvular surgery, or combined procedures: a systematic review with meta-analysis.
BACKGROUND
New postoperative atrial fibrillation (POAF) is one of the most critical and common complications after cardiovascular surgery precipitating early and late morbidities. Complete blood count (CBC) is an imperative blood test in clinical practice, routinely used in the examination of cardiovascular diseases.


AIM
This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of haematological indices in CBC tests with atrial fibrillation following isolated coronary artery bypass graft (CABG), isolated valvular surgery, or a combination of these treatments.


METHODS
We conducted a meta-analysis of studies evaluating pre- and postoperative haematological indices in patients with POAF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity.


RESULTS
A literature search of all major databases retrieved 732 studies. After screening, 22 studies were analysed including a total of 6098 patients. Pooled analysis showed preoperative platelet count (PC) (weighted mean difference [WMD] = -7.07 × 10^9/L and p < 0.001), preoperative mean platelet volume (MPV) (WMD = 0.53 FL and p < 0.001), preoperative white blood cell count (WBC) (WMD = 0.130 × 10^9/L and p < 0.001), preoperative neutrophil-to-lymphocyte ratio (NLR) (WMD = 0.33 and p < 0.001), preoperative red blood cell distribution width (RDW) (WMD = 0.36% and p < 0.001), postoperative WBC (WMD = 1.36 × 10^9/L and p < 0.001), and postoperative NLR (WMD = 0.74 and p < 0.001) as associated factors with POAF.


CONCLUSIONS
Haematological indices may predict the risk of POAF before surgery. These easily-performed tests should definitely be taken into account in patients undergoing isolated CABG, valvular surgery, or combined procedures.
['Weymann|Alexander|A|', 'Ali-Hasan-Al-Saegh|Sadeq|S|', 'Popov|Aron-Frederik|AF|', 'Sabashnikov|Anton|A|', 'Mirhosseini|Seyed Jalil|SJ|', 'Liu|Tong|T|', 'Tse|Gary|G|', 'Lotfaliani|Mohammadreza|M|', 'Ghanei|Azam|A|', 'Testa|Luca|L|', "D'Ascenzo|Fabrizio|F|", 'Benedetto|Umberto|U|', 'Dehghan|Hamidreza|H|', 'Roever|Leonardo|L|', 'Sá|Michel Pompeu Barros de Oliveira|MPBO|', 'Baker|William L|WL|', 'Yavuz|Senol|S|', 'Zeriouh|Mohamed|M|', 'Mashhour|Ahmed|A|', 'Nombela-Franco|Luis|L|', 'Jang|Jae-Sik|JS|', 'Meng|Lei|L|', 'Gong|Mengqi|M|', 'Deshmukh|Abhishek J|AJ|', 'Palmerini|Tullio|T|', 'Linde|Cecilia|C|', 'Filipiak|Krzysztof J|KJ|', 'Biondi-Zoccai|Giuseppe|G|', 'Calkins|Hugh|H|', 'Stone|Gregg W|GW|']
D000368:Aged D001281:Atrial Fibrillation D006348:Cardiac Surgical Procedures D001026:Coronary Artery Bypass D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D011183:Postoperative Complications D011379:Prognosis
atrial fibrillation coronary artery bypass review meta-analysis complete blood count cardiac surgical procedure