Analysis of the Effect of IL-1β on Blood-Brain Barrier Permeability in M6 Glioma Mouse Model Using Intravital Microscopy.
We studied the effect of IL-1β on the permeability of brain capillaries in healthy mice. Intravital microscopy demonstrated that parenteral administration of IL-1β was followed by an increase in vascular permeability ensuring passage of free Alexa488 fluorescent label through the capillary walls, but not sufficient for penetration of liposomes. In addition, experiments on mice with intracranial M6 glioma showed penetration of liposomes through the walls of tumor capillaries after parenteral administration of IL-1β in a concentration of 2 μg/ml. Thus, the use of proinflammatory cytokine IL-1β in the therapy of brain tumors can significantly increase the therapeutic efficacy of drug delivery systems, in particular, for drugs poorly crossing the blood-brain barrier.
['Melnikov|P A|PA|', 'Valikhov|M P|MP|', 'Kuznetsov|I I|II|', 'Grinenko|N F|NF|', 'Sukhinich|K K|KK|', 'Simbirtsev|A S|AS|', 'Kekelidze|Z I|ZI|', 'Chekhonin|V P|VP|']
D000818:Animals D001692:Biological Transport D001812:Blood-Brain Barrier D045744:Cell Line, Tumor D004195:Disease Models, Animal D005260:Female D005910:Glioma D053583:Interleukin-1beta D000069416:Intravital Microscopy D008081:Liposomes D051379:Mice D008810:Mice, Inbred C57BL
IL-1β liposomes brain tumors blood—brain barrier targeted drug delivery