Assessment of heavy metals, fungicide quintozene and its hazardous impurity residues in medical Panax notoginseng (Burk) F.H.Chen root.
A quick, easy, cheap, effective, rugged, and safe extraction approach and gas chromatography/tandem mass spectrometry with programmed temperature vaporization sampling technology were used to determine fungicide quintozene and its hazardous impurity hexachlorobenzene (HCB) in Panax notoginseng root, which is commonly used as a rare traditional Chinese medicine worldwide. The mean recoveries were in the ranges of 94-125 and 84-119% for quintozene and HCB with relative standard deviations of 6.2-16.1% at three concentrations: 0.01, 0.1 and 1 mg kg-1 . Heavy metals arsenic, cadmium, copper and lead were simultaneously detected by an inductively coupled plasma-mass spectrometry approach after digestion with nitric acid. The above methods were used to analyze 50 samples of P. notoginseng roots collected at markets and planting bases from the special local producing areas, namely, Honghe, Kunming and Wenshan in Yunnan province, China. Quintozene and HCB in root samples were determined at <0.0015-1.50 and <0.0015-0.125 mg kg-1 . In the 50 samples, 60, 16, 56, 2 and 6% exceeded the maximum permissible levels in medicinal plants (WM/T2-2004) for quintozene, arsenic, cadmium, lead and copper. The results showed that the method is robust and suitable for measuring quintozene, its hazardous impurity and heavy metals in P. notoginseng roots.
['Geng|Yue|Y|http://orcid.org/0000-0001-7097-9689', 'Jiang|Linjie|L|', 'Jiang|Hongxin|H|', 'Wang|Lu|L|', 'Peng|Yi|Y|', 'Wang|Ce|C|', 'Shi|Xiaomeng|X|', 'Gu|Jing|J|', 'Wang|Yuehua|Y|', 'Zhu|Jiachao|J|', 'Dai|Lihong|L|', 'Xu|Yaping|Y|', 'Liu|Xiaowei|X|']
D004365:Drugs, Chinese Herbal D005659:Fungicides, Industrial D008401:Gas Chromatography-Mass Spectrometry D057230:Limit of Detection D016014:Linear Models D019216:Metals, Heavy D009578:Nitrobenzenes D053723:Panax notoginseng D010573:Pesticide Residues D018517:Plant Roots D015203:Reproducibility of Results D018570:Risk Assessment
heavy metal Panax notoginseng (Burk) F.H.Chen root Chinese traditional herbal medicine health risk assessment pesticide residue