Polystyrene Microplastics Exposure: An Insight into Multiple Organ Histological Alterations, Oxidative Stress and Neurotoxicity in Javanese Medaka Fish (Oryzias javanicus Bleeker, 1854).
Microplastics (MPs) have become pollutants of concern due to their unknown human health effect and negative impact on terrestrial and aquatic ecosystems. There is increasing number of experimental research on MPs globally with its effects not fully understood; recent animal studies explore its effects on the intestines, yet on other vital organs. Javanese medaka fish was exposed to polystyrene microplastics (PS-MPs) beads for a period of 21 days. Histological alterations, intestinal oxidative stress, permeability and neurotoxicity were evaluated. Significant inflammatory changes and tissue damage were observed in the intestine, liver and kidney. Intestinal oxidative stress and permeability were found to be significantly increased. In the brain, neurotoxicity characterised by a significant induction of oxidative stress, lipid peroxidation and the inhibition of acetylcholinesterase enzyme were elucidated. This study provided an insight into the multiple organ effect of microplastics exposure, necessitating further exploration and identification of biomarkers to be utilised for biomonitoring population at risk in the future.
['Usman|Sunusi|S|0000-0003-4563-937X', 'Abdull Razis|Ahmad Faizal|AF|0000-0001-9205-3764', 'Shaari|Khozirah|K|', 'Amal|Mohammad Noor Azmai|MNA|0000-0002-7664-9821', 'Saad|Mohd Zamri|MZ|0000-0002-9013-4883', 'Mat Isa|Nurulfiza|N|', 'Nazarudin|Muhammad Farhan|MF|0000-0001-9447-524X']
D000110:Acetylcholinesterase D000818:Animals D017753:Ecosystem D007214:Indonesia D000080545:Microplastics D009990:Oryzias D018384:Oxidative Stress D010969:Plastics D011137:Polystyrenes D014874:Water Pollutants, Chemical
polystyrene microplastics histological alterations oxidative stress neurotoxicity Javanese medaka fish