Application of iPS cell-derived macrophages to cancer therapy.
We established a method to produce a large quantity of myeloid cells from human inducible pluripotent stem cells (iPSCs). When injected intraperitoneally into mice carrying established peritoneal tumors, iPSC-derived myeloid cells (iPS-MCs) efficiently accumulated within neoplastic lesions. The intraperitoneal injection of iPS-MCs expressing interferon β significantly inhibited the growth of human gastric and pancreatic cancers implanted in the peritoneal cavity of immunocompromised mice.
['Senju|Satoru|S|', 'Koba|Chihiro|C|', 'Haruta|Miwa|M|', 'Matsunaga|Yusuke|Y|', 'Matsumura|Keiko|K|', 'Haga|Eriko|E|', 'Sasaki|Yuko|Y|', 'Ikeda|Tokunori|T|', 'Takamatsu|Koutaro|K|', 'Nishimura|Yasuharu|Y|']
macrophages interferon β pancreatic cancer gastric cancer iPS cells peritoneal dissemination