PCC characteristics at rest in 10-year memory decliners.
The present research sought to characterize the intrinsic functional networks associated with a 10-year episodic memory decline in elderly using data from a longitudinal population-based cohort (Bordeaux-3City). Complementary measures of whole-brain resting-state functional magnetic resonance imaging investigations were combined to compare functional architecture of brain networks both at connectional and topological levels in 22 decliners to 22 nondecliners; episodic memory decline being assessed through a multiple time point Free and Cued Selective Reminding Test. The decliners presented differences in functional architecture centered on the posterior cingulate cortex, characterized by a significant decrease of connectivity intensity, a significant increased centrality. In accordance, a decrease of the functional connectivity inside the default mode network was observed in the decliners. Our results highlight the central role of the posterior cingulate cortex in a slow but reliable memory decline in elderly. Because functional alterations of this region are currently described in Alzheimer's disease, this functional signature could constitute a risk for Alzheimer's disease.
['Bernard|Charlotte|C|', 'Dilharreguy|Bixente|B|', 'Helmer|Catherine|C|', 'Chanraud|Sandra|S|', 'Amieva|Hélène|H|', 'Dartigues|Jean-François|JF|', 'Allard|Michèle|M|', 'Catheline|Gwénaëlle|G|']
D000368:Aged D000369:Aged, 80 and over D000375:Aging D000544:Alzheimer Disease D015331:Cohort Studies D005260:Female D006179:Gyrus Cinguli D006801:Humans D008137:Longitudinal Studies D008279:Magnetic Resonance Imaging D008297:Male D008568:Memory D059906:Neuroimaging D012146:Rest D013997:Time Factors
PCC Memory decline Aging Graph theory NBS Resting-state fMRI