Neurological diseases and risk of suicide attempt: a case-control study.
INTRODUCTION
Neurological diseases have a profound impact on quality of life. We investigated the risk of suicide attempt in ten neurological diseases.


METHODS
Case-control study. Cases were identified from the Danish Poison Information Centre database in the period 2006-2013. The prevalence of ten neurological diagnoses was compared with the prevalence in a randomly sampled age- and gender-matched control group.


RESULTS
We identified 8974 cases of suicidal attempt and 89,740 controls. We found an association between suicide attempt in nine of ten neurological diseases and disease groups, including stroke [odds ratio (OR) 3.1, 95% confidence interval (CI) (2.8-3.6)], Huntington's disease [OR 8.8, 95% CI (3.2-24.1)], amyotrophic lateral sclerosis [OR 5.0, 95% CI (1.7-14.6)], Parkinson's disease [OR 2.9, 95% CI (1.8-4.6)], Alzheimer's disease and other degenerative diseases [OR 4.8, 95% CI (3.1-7.5)], multiple sclerosis [OR 1.5, 95% CI (1.1-2.1)], epilepsy [OR 4.5, 95% CI (4.1-5.0)], hereditary and idiopathic neuropathy [OR 2.2, 95% CI (1.1-4.3)] and myasthenia gravis [OR 4.3, 95% CI (2.0-9.4)].


CONCLUSION
Nine out of ten chronic neurological diseases were associated with an increased risk of suicide attempt. These data must be considered for clinicians treating this vulnerable group of patients.
['Eliasen|Astrid|A|', 'Dalhoff|Kim Peder|KP|', 'Horwitz|Henrik|H|']
D000328:Adult D000368:Aged D016022:Case-Control Studies D002908:Chronic Disease D015897:Comorbidity D003718:Denmark D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D009422:Nervous System Diseases D016017:Odds Ratio D011041:Poisoning D015995:Prevalence D011446:Prospective Studies D012042:Registries D012307:Risk Factors D013406:Suicide, Attempted
Neurological diseases Suicide attempt Neuropsychiatry Self-poisoning