Nanoscale Delivery of Resveratrol towards Enhancement of Supplements and Nutraceuticals.
Resveratrol was investigated in terms of its stability, biocompatibility and intestinal permeability across Caco-2 cell monolayers in its free form or encapsulated in solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). SLNs and NLCs presented a mean diameter between 160 and 190 nm, high negative zeta potential of -30 mV and resveratrol entrapment efficiency of 80%, suggesting they are suitable for resveratrol oral delivery. Nanoencapsulation effectively protected resveratrol from photodegradation, and MTT assays demonstrated that neither resveratrol nor lipid nanoparticles adversely affected cell viability and integrity of Caco-2 cell monolayers. The in vitro intestinal permeability of resveratrol was significantly increased by NLCs, and SLNs did not impair the absorption of resveratrol. Resveratrol oral absorption can be enhanced during meals, since the intestinal permeability was increased in the presence of fed-state intestinal juices. SLNs and NLCs constitute carrier systems for resveratrol oral administration, for further use as supplements or nutraceuticals.
['Neves|Ana Rute|AR|', 'Martins|Susana|S|', 'Segundo|Marcela A|MA|', 'Reis|Salette|S|']
D000284:Administration, Oral D018938:Caco-2 Cells D019587:Dietary Supplements D004337:Drug Carriers D004339:Drug Compounding D004355:Drug Stability D006801:Humans D007408:Intestinal Absorption D007413:Intestinal Mucosa D007419:Intestinal Secretions D008055:Lipids D053758:Nanoparticles D036103:Nanotechnology D010539:Permeability D000077185:Resveratrol D013267:Stilbenes D013997:Time Factors
resveratrol biocompatibility intestinal permeability lipid nanoparticles nanodelivery systems oral bioavailability