BCG-induced trained immunity in macrophage: reprograming of glucose metabolism.
Memory is no longer a privilege of adaptive immunity. Innate immune cells can exhibit a long-term immune activation after infection or vaccination, which is called "trained immunity." In addition to defense against mycobacterial infection, BCG-induced trained immunity can also exert nonspecific protection, which is regulated by metabolic rewiring and epigenetic reprograming. Enhanced glycolysis and glutamine-driven tricarboxylic acid cycle have been proven to be important metabolic pathways for trained immunity induced by BCG, which is dependent on Akt/mTOR pathway.
['Liu|Yuntong|Y|', 'Liang|Shu|S|', 'Ding|Ru|R|', 'Hou|Yuyang|Y|', 'Deng|Feier|F|', 'Ma|Xiaohui|X|', 'Song|Tiantian|T|', 'Yan|Dongmei|D|0000-0002-8314-491X']
D000818:Animals D065150:Cellular Reprogramming D044127:Epigenesis, Genetic D005947:Glucose D005973:Glutamine D006801:Humans D007109:Immunity D008264:Macrophages D009163:Mycobacterium bovis D009169:Mycobacterium tuberculosis D051058:Oncogene Protein v-akt D015398:Signal Transduction D058570:TOR Serine-Threonine Kinases D014233:Tricarboxylic Acids D014376:Tuberculosis
trained immunity macrophage glucose metabolism BCG