Association of Serum Triglyceride Level and Gemfibrozil Consumption With Periodontal Status.
BACKGROUND
Hyperlipidemia is a major risk factor for cardiovascular diseases. Considering the suggested association between periodontal and cardiovascular diseases, this study sought to assess the association, if any, between serum triglyceride (TG) levels and gemfibrozil consumption with periodontal parameters.


METHODS
This cross-sectional study was conducted on 90 participants, including 30 individuals with a normal lipid profile (group H), 30 patients with hypertriglyceridemia and not on medication (group N), and 30 patients with hypertriglyceridemia and taking gemfibrozil over a 3-month period (group M). Periodontal parameters including probing depth (PD), clinical attachment level (CAL), bleeding on probing (BOP), and plaque index were measured at four sites of each tooth. Serum levels of total cholesterol (TC), TG, low-density lipoprotein, and high-density lipoprotein were measured.


RESULTS
Mean values for PD and CAL in the two hypertriglyceridemic groups were significantly higher than those of the H group (P <0.001). After controlling for confounding variables, significant linear correlations were noted between PD and BOP, PD and TC, PD and TG, and CAL and TG in each group (P <0.01).


CONCLUSIONS
Patients with hypertriglyceridemia had worse periodontal status than healthy controls. Patients with hypertriglyceridemia who were taking gemfibrozil did not show significant differences in CAL and PD compared with untreated patients with hypertriglyceridemia.
['Sayar|Ferena|F|', 'Akhondi|Nasrin|N|', 'Fallah|Soltanali|S|', 'Moalemnia|Amir Abbas|AA|', 'Cheraghi|Azra|A|']
D000328:Adult D003430:Cross-Sectional Studies D003774:Dental Plaque Index D005260:Female D015248:Gemfibrozil D006801:Humans D015228:Hypertriglyceridemia D000960:Hypolipidemic Agents D008297:Male D008875:Middle Aged D010510:Periodontal Diseases D010512:Periodontal Index D014280:Triglycerides
gemfibrozil hyperlipidemias risk factors Cardiovascular diseases hypertriglyceridemia periodontal diseases