Risk factors related to cardiovascular diseases and the metabolic syndrome in multiple sclerosis - a systematic review.
Despite many epidemiological studies examining comorbidity in people with multiple sclerosis (pMS), there are conflicting opinions on whether pMS are at more or less risk of cardiovascular disease (CVD) and the metabolic syndrome compared with the general population. As pMS can now expect longer survival, this as an important question both at an individual and public health level. This study aimed to systematically review the literature linking MS to CVD risks and to the risk factors constituting the metabolic syndrome. This systematic review is based on a comprehensive literature search of six databases (Swemed+, Pubmed, Embase, Cochrane, PEDro and CINAHL). In total 34 studies were identified. Despite the high number of identified papers, only limited and inconsistent data exist on the risk factors of the metabolic syndrome and MS. Overall, the data suggest an increased CVD risk in pMS. From the existing studies it is not clear whether the increased risk of CVD is related to an increased risk of obesity or changes in body composition, hypertension, dyslipidemia or type II diabetes in pMS, indicating the need for future research in the field, if we are to advise pMS adequately in avoiding preventable comorbidity.
['Wens|Inez|I|', 'Dalgas|Ulrik|U|', 'Stenager|Egon|E|', 'Eijnde|Bert O|BO|']
D050154:Adiposity D001823:Body Composition D015992:Body Mass Index D002318:Cardiovascular Diseases D003924:Diabetes Mellitus, Type 2 D050171:Dyslipidemias D018149:Glucose Intolerance D006801:Humans D006973:Hypertension D024821:Metabolic Syndrome D009103:Multiple Sclerosis D009765:Obesity D012307:Risk Factors
Cardiovascular diseases metabolic syndrome multiple sclerosis body composition hypertension dyslipidemia glucose intolerance