Modelling the Impact of Chronic Cigarette Smoke Exposure in Obese Mice: Metabolic, Pulmonary, Intestinal, and Cardiac Issues.
Unhealthy lifestyle choices, such as bad eating behaviors and cigarette smoking, have major detrimental impacts on health. However, the inter-relations between obesity and smoking are still not fully understood. We thus developed an experimental model of high-fat diet-fed obese C57BL/6 male mice chronically exposed to cigarette smoke. Our study evaluated for the first time the resulting effects of the combined exposure to unhealthy diet and cigarette smoke on several metabolic, pulmonary, intestinal, and cardiac parameters. We showed that the chronic exposure to cigarette smoke modified the pattern of body fat distribution in favor of the visceral depots in obese mice, impaired the respiratory function, triggered pulmonary inflammation and emphysema, and was associated with gut microbiota dysbiosis, cardiac hypertrophy and myocardial fibrosis.
['Dubois-Deruy|Emilie|E|', 'Rémy|Gaëlle|G|', 'Alard|Jeanne|J|', 'Kervoaze|Gwenola|G|', 'Chwastyniak|Maggy|M|', 'Baron|Morgane|M|', 'Beury|Delphine|D|', 'Siegwald|Léa|L|', 'Caboche|Ségolène|S|0000-0002-3658-3477', 'Hot|David|D|0000-0002-2361-0616', 'Gosset|Philippe|P|0000-0002-4043-6429', 'Grangette|Corinne|C|', 'Pinet|Florence|F|0000-0002-5471-1487', 'Wolowczuk|Isabelle|I|', 'Pichavant|Muriel|M|']
D000273:Adipose Tissue D000818:Animals D015415:Biomarkers D006332:Cardiomegaly D016207:Cytokines D004195:Disease Models, Animal D004198:Disease Susceptibility D004734:Energy Metabolism D004781:Environmental Exposure D005947:Glucose D006706:Homeostasis D006801:Humans D007328:Insulin D008019:Life Style D008168:Lung D008297:Male D051379:Mice D064307:Microbiota D009765:Obesity D009928:Organ Specificity D012907:Smoking
cigarette obesity metabolism unhealthy lifestyle gut microbiota heart lung