Aortic Dissection in Takayasu Arteritis.
BACKGROUND
Aortic dissection (AD) is a rare complication of Takayasu arteritis (TA). The clinical presentation and long-term management outcomes of AD in patients with TA have not been well described.


MATERIALS AND METHODS
We conducted a retrospective study of patients with TA along with AD admitted to Fuwai Hospital between January 1985 and March 2016. Clinical data and follow-up data were collected and analyzed.


RESULTS
Of the 1,154 patients with TA, we identified 10 patients (0.87%) with AD, which was likely to be associated with vasculitis. All patients were females with a median age at TA onset of 26.5 years (range: 18.3-33.3 years), had type III TA and had a history of hypertension, which was much more common than that in previously reported cases. Stanford type B or DeBakey category III was the dominant anatomic classification of AD. Four patients developed AD after the diagnosis of TA, and 6 developed AD near the time of TA diagnosis. Nine patients underwent conservative treatment, whereas 1 patient underwent endovascular repair due to extensive dissection. At a median 70.5-month follow-up (range: 31.5-138.5), we found that 7 patients had no AD progression, 1 patient had progressed without symptoms, 1 patient was lost and 1 patient died.


CONCLUSIONS
Patients with TA along with long-standing and poorly controlled hypertension are liable to develop AD. Those with extensive AD in TA should be carefully treated and intensively followed up.
['Yang|Kun-Qi|KQ|', 'Yang|Yan-Kun|YK|', 'Meng|Xu|X|', 'Zhang|Ying|Y|', 'Zhang|Hui-Min|HM|', 'Wu|Hai-Ying|HY|', 'Liu|Ya-Xin|YX|', 'Jiang|Xiong-Jing|XJ|', 'Cai|Jun|J|', 'Zhou|Xian-Liang|XL|', 'Hui|Ru-Tai|RT|', 'Zheng|De-Yu|DY|', 'Liu|Li-Sheng|LS|']
D000293:Adolescent D000328:Adult D000784:Aneurysm, Dissecting D001014:Aortic Aneurysm D005260:Female D006801:Humans D008297:Male D012189:Retrospective Studies D013625:Takayasu Arteritis D055815:Young Adult
Aortic dissection Takayasu arteritis Hypertension Inflammation