Striatonigral direct pathway activation is sufficient to induce repetitive behaviors.
Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a specific neural circuit and repetitive behavior has not yet been established. Here we demonstrate that optogenetic activation of dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.
['Bouchekioua|Youcef|Y|', 'Tsutsui-Kimura|Iku|I|', 'Sano|Hiromi|H|', 'Koizumi|Miwako|M|', 'Tanaka|Kenji F|KF|', 'Yoshida|Keitaro|K|', 'Kosaki|Yutaka|Y|', 'Watanabe|Shigeru|S|', 'Mimura|Masaru|M|']
D000818:Animals D001522:Behavior, Animal D003342:Corpus Striatum D004298:Dopamine D008822:Mice, Transgenic D009434:Neural Pathways D065841:Pars Reticulata D017447:Receptors, Dopamine D1 D013378:Substantia Nigra
Direct pathway Repetitive behaviors Optogenetics Autistic spectrum disorder (ASD) D1-MSNs Obsessive-compulsive spectrum disorders (OCSD) Striato-nigral pathway Tourette syndrom