Effect of neostigmine on contractility of equine pre-ovulatory follicles: An in vitro study.
In this study, the Authors investigated the modulatory effect of three single doses (10-6, 10-5, and 10-4 M) of neostigmine on the spontaneous contractility of equine pre-ovulatory follicles in an isolated organ bath, to establish the relationship between this acetylcholinesterase inhibitor and ovulation, in the mare. The results indicate that neostigmine increases pre-ovulatory contractility in equine follicles at each dose, but in a different manner. Indeed, the rise in contractility induced by neostigmine at 10-6 M and 10-4 M was phasic, while at 10-5 M it was tonic. The data obtained indicate possible implications of these drugs in the pharmacological modulation of equine ovulation.
['Piccinno|M|M|', 'Rizzo|A|A|', 'Cariello|G|G|', 'Sciorsci|R L|RL|']
D000818:Animals D004305:Dose-Response Relationship, Drug D005260:Female D006736:Horses D066298:In Vitro Techniques D009388:Neostigmine D006080:Ovarian Follicle D011374:Progesterone
Neostigmine Contractility Pre-ovulatory follicles Mare