Impact of heart magnetic resonance imaging on chelation choices, compliance with treatment and risk of heart disease in patients with thalassaemia major.
This study aimed to verify the impact of heart magnetic resonance imaging on chelation choices and patient compliance in a single-institution cohort as well as its predictive value for heart failure and arrhythmias. Abnormal cardiac T2* values determined changes in treatment in most subjects. Heart T2* was confirmed to be highly predictive over 1 year for heart failure and arrhythmias. The choice of chelation regimens known to remove heart iron efficiently was not sufficient by itself to influence the risk. Compliance with treatment had a more remarkable role.
['Origa|Raffaella|R|', 'Danjou|Fabrice|F|', 'Cossa|Stefano|S|', 'Matta|Gildo|G|', 'Bina|Patrizio|P|', 'Dessì|Carlo|C|', 'Defraia|Elisabetta|E|', 'Foschini|Maria L|ML|', 'Leoni|Giovanbattista|G|', 'Morittu|Maddalena|M|', 'Galanello|Renzo|R|']
D000328:Adult D019540:Area Under Curve D001145:Arrhythmias, Cardiac D001565:Benzoates D015913:Chelation Therapy D000077588:Deferasirox D000077543:Deferiprone D003676:Deferoxamine D004305:Dose-Response Relationship, Drug D004359:Drug Therapy, Combination D005260:Female D006333:Heart Failure D006801:Humans D007501:Iron D007502:Iron Chelating Agents D019190:Iron Overload D008279:Magnetic Resonance Imaging D008297:Male D009206:Myocardium D010349:Patient Compliance D011237:Predictive Value of Tests D011728:Pyridones D012372:ROC Curve D012306:Risk D012494:Sampling Studies D065227:Transfusion Reaction D014230:Triazoles D055815:Young Adult D017086:beta-Thalassemia
heart magnetic resonance imaging compliance heart failure arrhythmia beta thalassaemia major