Zebrafish in Inflammasome Research.
Inflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses to danger stimuli and infection, and their dysregulation is associated with an increasing number of autoinflammatory diseases. In recent years, zebrafish models of human pathologies to study inflammasome function in vivo have started to emerge. Here, we discuss inflammasome research in zebrafish in light of current knowledge about mammalian inflammasomes. We summarize the evolutionary conservation of inflammasome components between zebrafish and mammals, highlighting the similarities and possible divergence in functions of these components. We present new insights into the evolution of the caspase-1 family in the teleost lineage, and how its evolutionary origin may help contextualize its functions. We also review existing infectious and non-infectious models in zebrafish in which inflammasomes have been directly implicated. Finally, we discuss the advantages of zebrafish larvae for intravital imaging of inflammasome activation and summarize available tools that will help to advance inflammasome research.
['Forn-Cuní|Gabriel|G|0000-0001-5976-4759', 'Meijer|Annemarie H|AH|0000-0002-1325-0725', 'Varela|Monica|M|0000-0003-0215-9173']
D000818:Animals D020169:Caspases D006801:Humans D058847:Inflammasomes D007249:Inflammation D007814:Larva D023421:Models, Animal D000069292:Pyroptosis D015027:Zebrafish
zebrafish inflammasome evolutionary conservation intravital imaging animal models gasdermin inflammatory caspases pyroptosis