New 4,5-seco-20(10→5)-abeo-Abietane Diterpenoids with Anti-Inflammatory Activity from Isodon lophanthoides var. graciliflorus (Benth.) H.Hara.
Three new 4,5-seco-20(10→5)-abeo-abietane diterpenoids, 16-hydroxysalvilenone (1), 15-hydroxysalprionin (2), and 11β,15-dihydroxysalprionin-12-one (3), and nine known abietane diterpenoids, 4-12, along with one known sempervirane diterpenoid, hispidanol A (13), were isolated from the aerial parts of Isodon lophanthoides var. graciliflorus. The structures of compounds 1-3 were determined on the basis of spectroscopic methods including extensive analysis of NMR and mass spectroscopic data. All diterpenoids were tested for their TNF-α inhibitory effects on LPS-induced RAW264.7 cells. Compound 9 (16-acetoxyhorminone) was the most potent with an IC50 value of 3.97±0.70 μm.
['Chen|Wen-Fei|WF|', 'Wong|Lai-Lai|LL|', 'Zhang|Xuan|X|', 'Zhou|Feng-Xu|FX|', 'Xia|Fan|F|', 'Tang|Li-Ping|LP|http://orcid.org/0000-0001-9115-4643', 'Li|Xian|X|']
D045784:Abietanes D000818:Animals D000893:Anti-Inflammatory Agents D037602:Isodon D008070:Lipopolysaccharides D008264:Macrophages D051379:Mice D008968:Molecular Conformation D035261:Plant Components, Aerial D010936:Plant Extracts D000067996:RAW 264.7 Cells
Isodon lophanthoides, 4,5-seco-20(10→5)-abeo-abietane diterpenoid, structure elucidation, anti-inflammatory activity, biological activity.