Identification of novel adenovirus genotype 90 in children from Bangladesh.
Novel adenovirus genotypes are associated with outbreaks of disease, such as acute gastroenteritis, renal disease, upper respiratory tract infection and keratoconjunctivitis. Here, we identify novel and variant adenovirus genotypes in children coinfected with enterotoxigenic Escherichia coli, in Bangladesh. Metagenomic sequencing of stool was performed and whole adenovirus genomes were extracted. A novel species D virus, designated genotype 90 (P33H27F67) was identified, and the partial genome of a putative recombinant species B virus was recovered. Furthermore, the enteric types HAdV-A61 and HAdV-A40 were found in stool specimens. Knowledge of the diversity of adenovirus genomes circulating worldwide, especially in low-income countries where the burden of disease is high, will be required to ensure that future vaccination strategies cover the diversity of adenovirus strains associated with disease.
['Houldcroft|Charlotte J|CJ|', 'Beale|Mathew A|MA|', 'Sayeed|Md Abu|MA|', 'Qadri|Firdausi|F|', 'Dougan|Gordon|G|', 'Mutreja|Ankur|A|']
D000258:Adenovirus Infections, Human D000260:Adenoviruses, Human D001459:Bangladesh D002648:Child D002675:Child, Preschool D005243:Feces D005260:Female D005759:Gastroenteritis D016679:Genome, Viral D005838:Genotype D006801:Humans D007637:Keratoconjunctivitis D008297:Male
adenovirus metagenomics DNA virus de novo assembly diarrhoeal disease whole-genome sequencing