Comparison of clinicopathological characteristics between patients with occupational and non-occupational intrahepatic cholangiocarcinoma.
BACKGROUND
An outbreak of cholangiocarcinoma has been reported among workers of an offset color proof-printing department at a printing company in Japan. In this study, we compared the clinicopathological findings of this type of intrahepatic cholangiocarcinoma (occupational ICC) and non-occupational ICC.


METHODS
The clinical records of 51 patients with perihilar-type ICC who underwent liver resection, including five patients with occupational ICC were retrospectively reviewed. The clinicopathological features were compared.


RESULTS
In the occupational group, the patients were significantly younger (P < 0.01), while serum γ-glutamyl transpeptidase activity and the proportions of patients with regional dilatation of the bile ducts without tumor-induced obstruction were significantly higher (P = 0.041 and P < 0.01, respectively); the indocyanine green retention rate at 15 min was significantly lower (P = 0.020). On pathological examinations, precancerous or early cancerous lesions, such as biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct, were observed at various sites of the bile ducts in all occupational ICC patients; such lesions were observed in only six patients in the control group (P < 0.01).


CONCLUSIONS
The clinicopathological findings including age, liver function test results, diagnostic imaging findings, and pathological findings differed between the occupational and control groups.
['Hamano|Genya|G|', 'Kubo|Shoji|S|', 'Takemura|Shigekazu|S|', 'Tanaka|Shogo|S|', 'Shinkawa|Hiroji|H|', 'Kinoshita|Masahiko|M|', 'Ito|Tokuji|T|', 'Yamamoto|Takatsugu|T|', 'Wakasa|Kenichi|K|', 'Shibata|Toshihiko|T|']
D000328:Adult D001650:Bile Duct Neoplasms D001707:Biopsy, Needle D016022:Case-Control Studies D018281:Cholangiocarcinoma D018572:Disease-Free Survival D005260:Female D006498:Hepatectomy D006801:Humans D007150:Immunohistochemistry D007564:Japan D053208:Kaplan-Meier Estimate D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D064847:Multimodal Imaging D009361:Neoplasm Invasiveness D009367:Neoplasm Staging D009784:Occupational Diseases D016273:Occupational Exposure D011379:Prognosis D012189:Retrospective Studies D018570:Risk Assessment D018709:Statistics, Nonparametric D015996:Survival Rate D014057:Tomography, X-Ray Computed D018608:Ultrasonography, Doppler
Printing company Biliary intraepithelial neoplasia Intraductal papillary neoplasm of the bile duct Occupational cholangiocarcinoma Organic solvent