Percutaneous Closure of Perimembranous Ventricular Septal Defect with Modified Double-disk Occluder: What Is the Outcome at 10-year Follow-up?
OBJECTIVE
Percutaneous closure of perimembranous ventricular septal defect is one of the greatest challenges in interventional cardiology. The long-term follow-up data are still limited. This report presents our experience in percutaneous closure of perimembranous ventricular septal defect with modified double-disk occluder.


DESIGN
The study is a retrospective analysis of cases from the Changhai Hospital clinic database.


SETTING
We reviewed the clinic database from December 2001 to December 2005.


PATIENTS
We included 117 patients who underwent percutaneous closure of perimembranous ventricular septal defects.


OUTCOME MEASURES
Procedural data and complications were assessed by an expert panel of cardiologists.


RESULTS
Device implantation was successfully accomplished in 113 of a total 117 patients (96.6%). The mean age was 31.1 ± 12.5 years (range 2-56 years). The patients were followed for a period of 86-134 months. The diameter of defect was 2-15 mm (mean 4.9 ± 2.9 mm). The ventricular septal defect rim below the aortic valve was 1-5 mm. The mean diameter of device used was 6.9 ± 3.7 (range 4-24 mm). Four patients presented complete atrio-ventricular block within 1 week after the procedure and recovered within 3 weeks. No other patient encountered serious adverse events during the follow-up.


CONCLUSIONS
Percutaneous closure of ventricular septal defect is safe and effective in most selected patients with modified double-disk occluder. Additional studies with larger cohorts and longer follow-up are needed to evaluate its safety.
['Bai|Yuan|Y|', 'Liu|Jing|J|', 'Qin|Yong-Wen|YW|', 'Wu|Hong|H|', 'Zhao|Xian-Xian|XX|']
D000293:Adolescent D000328:Adult D001027:Aortography D054537:Atrioventricular Block D006328:Cardiac Catheterization D002648:Child D002675:Child, Preschool D002681:China D004452:Echocardiography D005260:Female D005500:Follow-Up Studies D006345:Heart Septal Defects, Ventricular D006801:Humans D008297:Male D008875:Middle Aged D011474:Prosthesis Design D012189:Retrospective Studies D055989:Septal Occluder Device D013997:Time Factors D016896:Treatment Outcome D055815:Young Adult
Closure Ventricular Septal Defect Catheterization