Resveratrol prevents the development of high blood pressure in spontaneously hypertensive rats through the inhibition of enhanced expression of Giα proteins 1.
Resveratrol (RV), a polyphenolic component of red wine, has been shown to attenuate high blood pressure (BP) in spontaneously hypertensive rats (SHRs). We previously found that the enhanced expression of Giα proteins plays a role in the pathogenesis of hypertension in SHRs. In the present study, we investigated whether this RV-induced decrease in BP in SHRs can be attributed to the ability of RV to inhibit the enhanced expression of Giα proteins and the upstream signaling molecules implicated in the overexpression of Giα proteins. Administration of RV (50 mg/kg per day) to prehypertensive 2-week-old SHRs for 6 weeks prevented the development of high BP and inhibited the enhanced expression of Giα proteins, the enhanced levels of superoxide anion (O2-) and NADPH oxidase activity, the enhanced activation (phosphorylation) of c-Src and growth factor receptors, as well as the enhanced levels of extracellular signal-regulated kinase 1/2 (ERK1/2) and protein kinase B (Akt) exhibited by vascular smooth muscle cells isolated from SHRs. In conclusion, these results indicate that RV attenuates the development of high BP in SHRs through the inhibition of enhanced levels of Giα proteins, oxidative stress, and the upstream signaling molecules that contribute to the overexpression of Giα proteins. These findings suggest that RV could potentially be used as a therapeutic agent in the treatment of cardiovascular complications including hypertension.
['Sarkar|Oli|O|', 'Li|Yuan|Y|', 'Anand-Srivastava|Madhu B|MB|']
D000818:Animals D000081247:CSK Tyrosine-Protein Kinase D004789:Enzyme Activation D019206:GTP-Binding Protein alpha Subunits, Gi-Go D005786:Gene Expression Regulation D006973:Hypertension D008297:Male D019950:Mitogen-Activated Protein Kinase 1 D048052:Mitogen-Activated Protein Kinase 3 D009131:Muscle, Smooth, Vascular D019255:NADPH Oxidases D010766:Phosphorylation D051057:Proto-Oncogene Proteins c-akt D051381:Rats D011918:Rats, Inbred SHR D000077185:Resveratrol D015398:Signal Transduction D013481:Superoxides
resveratrol blood pressure Giα proteins SHR VSMC cellules musculaires lisses vasculaires protéines Giα rat SHR tension artérielle