Effects of Regular Kefir Consumption on Gut Microbiota in Patients with Metabolic Syndrome: A Parallel-Group, Randomized, Controlled Study.
Several health-promoting effects of kefir have been suggested, however, there is limited evidence for its potential effect on gut microbiota in metabolic syndrome This study aimed to investigate the effects of regular kefir consumption on gut microbiota composition, and their relation with the components of metabolic syndrome. In a parallel-group, randomized, controlled clinical trial setting, patients with metabolic syndrome were randomized to receive 180 mL/day kefir (n = 12) or unfermented milk (n = 10) for 12 weeks. Anthropometrical measurements, blood samples, blood pressure measurements, and fecal samples were taken at the beginning and end of the study. Fasting insulin, HOMA-IR, TNF-α, IFN-γ, and systolic and diastolic blood pressure showed a significant decrease by the intervention of kefir (p ≤ 0.05, for each). However, no significant difference was obtained between the kefir and unfermented milk groups (p > 0.05 for each). Gut microbiota analysis showed that regular kefir consumption resulted in a significant increase only in the relative abundance of Actinobacteria (p = 0.023). No significant change in the relative abundance of Bacteroidetes, Proteobacteria or Verrucomicrobia by kefir consumption was obtained. Furthermore, the changes in the relative abundance of sub-phylum bacterial populations did not differ significantly between the groups (p > 0.05, for each). Kefir supplementation had favorable effects on some of the metabolic syndrome parameters, however, further investigation is needed to understand its effect on gut microbiota composition.
['Bellikci-Koyu|Ezgi|E|0000-0001-5279-2394', 'Sarer-Yurekli|Banu Pınar|BP|', 'Akyon|Yakut|Y|', 'Aydin-Kose|Fadime|F|0000-0001-5222-7555', 'Karagozlu|Cem|C|0000-0002-2874-4998', 'Ozgen|Ahmet Gokhan|AG|', 'Brinkmann|Annika|A|', 'Nitsche|Andreas|A|', 'Ergunay|Koray|K|', 'Yilmaz|Engin|E|', 'Buyuktuncer|Zehra|Z|']
D000293:Adolescent D000328:Adult D000368:Aged D001786:Blood Glucose D001835:Body Weight D005260:Female D000069196:Gastrointestinal Microbiome D006801:Humans D000070716:Kefir D008055:Lipids D008297:Male D024821:Metabolic Syndrome D008875:Middle Aged D010802:Phylogeny D055815:Young Adult
kefir gut microbiota metabolic syndrome