Dietary calcium intake influences the relationship between serum 25-hydroxyvitamin D3 (25OHD) concentration and parathyroid hormone (PTH) concentration.
OBJECTIVES
To investigate whether dietary calcium intake will modify the relationship between serum 25-hydroxyvitamin D3 (25OHD) with intact serum parathyroid hormone (PTH) concentrations in apparently healthy Indian adolescents.


STUDY DESIGN
Cross-sectional study.


SETTING AND PARTICIPANTS
Apparently healthy adolescents aged 10-14 years (n=181), from Gujarat, western India. Study conducted from January 2012 to March 2014.


METHODS
Serum 25OHD concentrations and intact serum PTH concentrations (both using chemiluminescent microparticle immunoassay) were measured. Diet was recorded through 24 h diet recall and calcium intake was computed (C-diet V.2.1). To assess relationship between 25OHD and PTH, data were dichotomised according to median calcium intakes (520 mg/day) and relationship between serum 25OHD and PTH in the two subgroups was plotted.


RESULTS
Subjects with calcium intakes above median (>520 mg/day) had lower intact serum PTH values for given serum 25OHD concentration while those with calcium intakes below median (<520 mg/day) had higher intact serum PTH values for given serum 25OHD concentration. Serum 25OHD concentration was negatively correlated with intact serum PTH concentration at lower as well as higher calcium intakes (r=- 0.606 and -0.483, respectively, p<0.01 for both). Using a regression analysis, predicted values for intact serum PTH concentration for the given serum 25OHD concentrations were plotted. The plot revealed a negative shift with increasing calcium intake.


CONCLUSIONS
Dietary calcium intake modifies the relationship between serum 25OHD concentrations and intact serum PTH concentrations. Thus, dietary calcium intake should be taken into account when assessing an individual's vitamin D status.
['Patel|Prerna|P|', 'Mughal|M Zulf|MZ|', 'Patel|Pinal|P|', 'Yagnik|Bhrugu|B|', 'Kajale|Neha|N|', 'Mandlik|Rubina|R|', 'Khadilkar|Vaman|V|', 'Chiplonkar|Shashi A|SA|', 'Phanse|Supriya|S|', 'Patwardhan|Vivek|V|', 'Patel|Ashish|A|', 'Khadilkar|Anuradha|A|']
D000293:Adolescent D000886:Anthropometry D002112:Calcifediol D002136:Calcium, Dietary D002648:Child D003430:Cross-Sectional Studies D004032:Diet D015930:Diet Records D005260:Female D006801:Humans D007194:India D008297:Male D010281:Parathyroid Hormone D012044:Regression Analysis
Calcium Parathyroid Hormone Vitamin D Adolescent Health