The Role of Biologic Therapies in Dermatology.
Biologic therapy has dramatically changed the way medicine, and specifically dermatology, is practiced today. The use of biologic agents in dermatology is evolving, with psoriasis being the most common indication for which biologics are used currently. However, several other dermatologic diseases seem to be responsive to biologic therapy, and continuing research and development efforts are elucidating the benefit-risk profiles of various biologic medications in these dermatologic conditions. Although biologic agents have revolutionized the management of dermatologic conditions, cost must also be considered when evaluating management options, especially compared with traditional agents. For example, the cost of 1 year of induction and maintenance treatment of psoriasis in 2014 was estimated to be $53,909 for ustekinumab, $46,395 for etanercept, and $39,041 for adalimumab. Nonetheless, because of their efficacy, the cost of a biologic may be offset by significant reductions in the number of hospital stays, reduction in use of other systemic therapies, and increased satisfaction by patients.32 Thus, understanding their mechanisms of action, labeled and off-label uses in dermatology, and common adverse effects helps to inform clinical decision making and improve patient outcomes.
['Fathi|Ramin|R|', 'Armstrong|April Wang|AW|']
D000068879:Adalimumab D000911:Antibodies, Monoclonal D061067:Antibodies, Monoclonal, Humanized D003879:Dermatologic Agents D000068800:Etanercept D006801:Humans D016756:Immunoglobulins, Intravenous D000069285:Infliximab D007378:Interleukins D000069283:Rituximab D012871:Skin Diseases D014409:Tumor Necrosis Factor-alpha D000069549:Ustekinumab
Biologics Dermatology Ustekinumab Etanercept Adalimumab IVIG Infliximab Secukinumab