Membrane-Bound Class III Peroxidases: Unexpected Enzymes with Exciting Functions.
Class III peroxidases are heme-containing proteins of the secretory pathway with a high redundance and versatile functions. Many soluble peroxidases have been characterized in great detail, whereas only a few studies exist on membrane-bound isoenzymes. Membrane localization of class III peroxidases has been demonstrated for tonoplast, plasma membrane and detergent resistant membrane fractions of different plant species. In silico analysis revealed transmembrane domains for about half of the class III peroxidases that are encoded by the maize (Zea mays) genome. Similar results have been found for other species like thale-cress (Arabidopsis thaliana), barrel medic (Medicago truncatula) and rice (Oryza sativa). Besides this, soluble peroxidases interact with tonoplast and plasma membranes by protein⁻protein interaction. The topology, spatiotemporal organization, molecular and biological functions of membrane-bound class III peroxidases are discussed. Besides a function in membrane protection and/or membrane repair, additional functions have been supported by experimental data and phylogenetics.
['Lüthje|Sabine|S|', 'Martinez-Cortes|Teresa|T|0000-0002-2081-0217']
D017360:Arabidopsis D002462:Cell Membrane D046913:Medicago truncatula D012275:Oryza D010544:Peroxidases D010802:Phylogeny D011485:Protein Binding D003313:Zea mays
Class III peroxidase tonoplast plasma membrane Zea mays Arabidopsis thaliana Medicago truncatula Oryza sativa phylogenetics microdomains protein–protein interaction