Protective activity of an anthocyanin-rich extract from bilberries and blackcurrants on acute acetaminophen-induced hepatotoxicity in rats.
Acetaminophen (N-acetyl-p-aminophenol, APAP) overdosage can produce fatal centrilobular hepatic necrosis in humans. The present study attempted to investigate the protective effect of an anthocyanin-rich extract from bilberries and blackcurrants (AE) against APAP-induced acute hepatic damage in rats. Treatment with AE normalised blood activities of glutamate oxaloacetate and glutamate pyruvate transaminase and prevented APAP-induced plasmatic and tissutal alterations in biomarkers of oxidative stress, probably due to various bioproperties of the components of the extract.
['Cristani|M|M|', 'Speciale|A|A|', 'Mancari|F|F|', 'Arcoraci|T|T|', 'Ferrari|D|D|', 'Fratantonio|D|D|', 'Saija|A|A|', 'Cimino|F|F|', 'Trombetta|D|D|']
Acetaminophen biomarkers oxidative stress anthocyanin hepatoprotection