Strain improvement of industrially important microorganisms based on resistance to toxic metabolites and abiotic stress.
Improvement of the biosynthetic capabilities of industrially relevant microbes to produce desired metabolites in higher quantities is one of the important topics of modern biotechnology. In this article, different strategies of improvement of mutated microbial strains are briefly described. This is followed by the first comprehensive review of the literature on obtaining high yielding microorganisms, that is, mutants exhibiting resistance to antimetabolites, nutritional repression, and abiotic stresses as well as tolerance to solvents and toxic substrates or products. Furthermore, the efficiency of the microbial metabolites produced by improved microbial strains, advantages, and limitations, as well as future prospects for strategies of strain development are discussed.
['Fiedurek|Jan|J|http://orcid.org/0000-0002-2977-1269', 'Trytek|Mariusz|M|', 'Szczodrak|Janusz|J|']
D000963:Antimetabolites D001419:Bacteria D001709:Biotechnology D004361:Drug Tolerance D005285:Fermentation D007218:Industrial Microbiology D053858:Metabolic Networks and Pathways D009154:Mutation D012997:Solvents D013312:Stress, Physiological
strain improvement toxic metabolites abiotic stresses mutants stress-tolerance