Leukocyte telomere length: a potential biomarker for the prognosis of coronary artery disease.
Aim: This study aimed to explore the prognostic value of leukocyte telomere length (LTL) in patients with coronary artery disease (CAD). Materials & methods: We enrolled 366 CAD patients and 76 healthy subjects in this study. LTL was measured. All subjects were followed up for 6 months for further analysis regarding major adverse cardiac events (MACEs). Results: CAD patients had a significantly shortened LTL compared with healthy subjects (p < 0.05). The area under the curve for LTL prediction of MACEs was 0.769 (p < 0.001), with a shorter LTL being an independent predictor of MACEs (Cox proportional hazards regression, hazard ratio: 2.866; p < 0.001). Conclusion: LTL could be considered as an independent predictor of short-term MACEs in CAD.
['Sun|Ying|Y|', 'Wang|Wei|W|', 'Jiao|Yue-Ru|YR|', 'Ren|Jian|J|', 'Gao|Lei|L|', 'Li|Yang|Y|', 'Hu|Ping|P|', 'Ren|Tian-Ying|TY|', 'Han|Qian-Feng|QF|', 'Chen|Chen|C|', 'Yao|Heng-Chen|HC|0000-0003-0291-8723']
D000368:Aged D015415:Biomarkers D003324:Coronary Artery Disease D005260:Female D006801:Humans D007962:Leukocytes D008297:Male D008875:Middle Aged D011379:Prognosis D012307:Risk Factors D016615:Telomere
leukocyte telomere length biomarker prognosis coronary artery disease