Metabolic targets of endocrine disrupting chemicals assessed by cord blood transcriptome profiling.
Early life exposure to endocrine disrupting chemicals (EDCs) has been frequently associated with impaired perinatal growth, an important risk factor for later onset of metabolic disorders. We analyzed whether the cord blood transcriptome showed early indications of alterations in metabolic processes in 195 human samples in relation to cord blood levels of dichlorodiphenyldichloroethylene (p,p'-DDE), polychlorinated biphenyl-153 (PCB-153), perfluorooctanoic acid (PFOA), and perfluorooctane sulfonate (PFOS). Overall, 39 metabolically relevant transcription factors were significantly enriched (31 by p,p'-DDE, 10 by PCB-153, 8 by PFOA, and 2 by PFOS). These included the glucocorticoid receptor (p,p'-DDE and PCB-153) and the progesterone receptor (PFOA and PFOS). The 'insulin receptor signaling', 'acute phase response signaling', 'Interleukin(IL)-6 signaling', and 'prolactin signaling' pathways were significantly enriched in relation to p,p'-DDE. Transcriptional changes at birth suggest a role for specific metabolic targets as a link between prenatal EDC exposure and metabolic disorders later in life.
['Remy|Sylvie|S|', 'Govarts|Eva|E|', 'Wens|Britt|B|', 'De Boever|Patrick|P|', 'Den Hond|Elly|E|', 'Croes|Kim|K|', 'Sioen|Isabelle|I|', 'Baeyens|Willy|W|', 'van Larebeke|Nicolas|N|', 'Koppe|Janna|J|', 'Covaci|Adrian|A|', 'Schettgen|Thomas|T|', 'Nelen|Vera|V|', 'Legler|Juliette|J|', 'Schoeters|Greet|G|']
D000328:Adult D001151:Arsenic D001530:Belgium D052244:Endocrine Disruptors D004784:Environmental Monitoring D004785:Environmental Pollutants D005260:Female D005312:Fetal Blood D005466:Fluorocarbons D020869:Gene Expression Profiling D006801:Humans D006843:Hydrocarbons, Chlorinated D007231:Infant, Newborn D008297:Male D019216:Metals, Heavy D010795:Phthalic Acids D011247:Pregnancy
Endocrine disrupting chemicals Cord blood Transcriptomics Metabolic disorders Glucocorticoid receptor Birth cohort