Intimal hyperplasia in loop-injured carotid arteries is attenuated in transglutaminase 2-null mice.
Arterial restenosis frequently develops after open or endovascular surgery due to intimal hyperplasia. Since tissue transglutaminase (TG2) is known to involve in fibrosis, wound healing, and extracellular matrix remodeling, we examined the role of TG2 in the process of intimal hyperplasia using TG2-null mice. The neointimal formation was compared between TG2-null and wild-type (C57BL/6) mice by two different injury models; carotid ligation and carotid loop injury. In ligation model, there was no difference in intimal thickness between two groups. In loop injury model, intimal hyperplasia developed in both groups and the intimal/medial area ratio was significantly reduced in TG2-null mice (P = 0.007). TG2 was intensely stained in neointimal cells in 2 weeks. In situ activity of TG2 in the injured arteries steadily increased until 4 weeks compared to uninjured arteries. Taken together, intimal hyperplasia was significantly reduced in TG2-null mice, indicating that TG2 has an important role in the development of intimal hyperplasia. This suggests that TG2 may be a novel target to prevent the arterial restenosis after vascular surgery.
['Min|Seung-Kee|SK|0000-0001-6849-3786', 'Min|Sang-Il|SI|', 'Jeong|Eui Man|EM|0000-0003-0692-2033', 'Cho|Sung-Yup|SY|0000-0002-2720-6952', 'Ha|Jongwon|J|', 'Kim|Sang Joon|SJ|', 'Kim|In-Gyu|IG|0000-0002-0751-4288']
D000818:Animals D002339:Carotid Arteries D004195:Disease Models, Animal D019204:GTP-Binding Proteins D006965:Hyperplasia D051379:Mice D008810:Mice, Inbred C57BL D000091345:Protein Glutamine gamma Glutamyltransferase 2 D011503:Transglutaminases D017539:Tunica Intima
Intimal Hyperplasia Tissue Transglutaminase Carotid Artery Injury