Towards the Shell Biorefinery: Sustainable Synthesis of the Anticancer Alkaloid Proximicin A from Chitin.
A shell biorefinery would involve fractionation of crustacean shells and incorporation of the components into value-added products, particularly those that contain nitrogen. In a proof-of-concept study that validates this concept, the anticancer alkaloid proximicin A has been synthesized from the chitin-derived platform chemical 3-acetamido-5-acetylfuran (3A5AF). This study accentuates the leading role chitin is likely to play in the sustainable production of nitrogen-containing fine chemicals that are not directly attainable from lignocellulose.
['Sadiq|Alejandro D|AD|', 'Chen|Xi|X|', 'Yan|Ning|N|', 'Sperry|Jonathan|J|0000-0001-7288-3939']
D060105:Animal Shells D000818:Animals D000970:Antineoplastic Agents D005591:Chemical Fractionation D002686:Chitin D003445:Crustacea D055772:Green Chemistry Technology D009429:Netropsin D000075082:Proof of Concept Study
shell biorefinery sustainable synthesis alkaloids biomass cancer