Circulating soluble receptor for advanced glycation end products is decreased and inversely associated with acute phase response in chronic spontaneous urticaria.
BACKGROUND
Activation of receptor for advanced glycation end products (RAGE) leads to the proinflammatory response and the release of its soluble form (sRAGE) which appears to function as an anti-inflammatory feedback mechanism.


AIM
To determine serum sRAGE concentration in CSU patients and its association with C-reactive protein (CRP) concentration, a nonspecific inflammatory marker of the disease activity.


METHODS
Concentrations of sRAGE and CRP were measured in serum of CSU patients and compared with the healthy controls.


RESULTS
Serum sRAGE concentrations were significantly decreased in CSU patients, especially those more severely affected. In addition, significant inverse correlations were observed between sRAGE and CRP concentrations.


CONCLUSIONS
Down-regulation of sRAGE and its association with acute phase response suggest a role for RAGE activation in the pathogenesis of CSU. It seems that lower serum sRAGE concentration may enhance the urticarial processes.
['Kasperska-Zajac|A|A|', 'Damasiewicz-Bodzek|A|A|', 'Tyrpień-Golder|K|K|', 'Zamlyński|J|J|', 'Grzanka|A|A|']
D000210:Acute-Phase Reaction D000328:Adult D002097:C-Reactive Protein D002908:Chronic Disease D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D000067759:Receptor for Advanced Glycation End Products D012720:Severity of Illness Index D012882:Skin Tests D014581:Urticaria
Soluble receptor for advanced glycation end products Acute phase response Chronic spontaneous urticaria C-reactive protein