CSF neurofilament light chain is elevated in OMS (decreasing with immunotherapy) and other pediatric neuroinflammatory disorders.
Using a panel of seven brain cell-specific biomarkers in cerebrospinal fluid (CSF), pediatric opsoclonus-myoclonus syndrome (OMS) (n=234) was compared to pediatric non-inflammatory neurological controls (n=84) and other inflammatory neurological disorders (OIND) (n=44). Only CSF NFL was elevated in untreated OMS versus controls (+83%). It was 87% higher in OIND than in OMS. On combination treatment with front-loaded ACTH, IVIg, rituximab, median CSF NFL decreased by 60% to control levels. These biochemical data suggest neuronal/axonal injury in some children with OMS without indicators of astrogliosis, and reduction on sufficient immunotherapy.
['Pranzatelli|Michael R|MR|', 'Tate|Elizabeth D|ED|', 'McGee|Nathan R|NR|', 'Verhulst|Steven J|SJ|']
D000293:Adolescent D000324:Adrenocorticotropic Hormone D000328:Adult D058846:Antibodies, Monoclonal, Murine-Derived D002648:Child D002675:Child, Preschool D003430:Cross-Sectional Studies D016207:Cytokines D004660:Encephalitis D005260:Female D006801:Humans D016756:Immunoglobulins, Intravenous D007155:Immunologic Factors D008297:Male D016900:Neurofilament Proteins D019370:Observation D053578:Opsoclonus-Myoclonus Syndrome D012189:Retrospective Studies D000069283:Rituximab D012720:Severity of Illness Index D055815:Young Adult
CSF cerebrospinal fluid other inflammatory neurological disorders OIND NFL ACTH IVIg ELISA GFAP NIND NND NSE Neuroblastoma Neurofilament pediatric ranges Opsoclonus–myoclonus syndrome Paraneoplastic syndrome Pediatric neuroinflammation S-100-beta protein S100B adrenocorticotropic hormone enzyme-linked immunosorbent assay glia fibrillary acidic protein intravenous immunoglobulins neurofilament light chain protein or low molecular weight subunit neuron specific enolase non-inflammatory neurological disorders non-inflammatory non-neurological disorders pNFH phosphorylated neurofilament heavy chain protein or high molecular weight subunit