Prognostic risk factors associated with esophageal squamous cell carcinoma patients undergoing endoscopic submucosal dissection: a multi-center cohort study.
BACKGROUND
Long-term outcomes of endoscopic submucosal dissection (ESD) for esophageal squamous cell carcinoma (ESCC) have not been assessed in a large, multicenter cohort. We aimed to evaluate long-term outcomes of ESD for ESCC in a real-world setting.


METHODS
We retrospectively recruited 659 patients who underwent ESD for ESCC at ten institutions from January 2007 to December 2015. Of these, 566 patients were analyzed and classified into three groups according to the pathologic invasion depth after ESD: epithelium/lamina propria mucosa (EP/LPM group: 454 patients), muscularis mucosa/submucosa invasion ≤ 200 μm below the inferior margin of the muscularis mucosa (MM/SM1 group: 81 patients), and submucosa invasion > 200 μm below the MM inferior margin (SM2 group: 31 patients).


RESULTS
The 5-year overall survival rates in the EP/LPM, MM/SM1, and SM2 groups were 92.6%, 80.0%, and 62.7%, respectively, while the 5-year disease-specific survival rates were 99.7%, 96.9%, and 88.3%, respectively. Multivariate analyses revealed that the invasion depth, Charlson Comorbidity Index (CCI), and prognostic nutritional index (PNI) were independent prognostic factors. Hazard ratios in the MM/SM1 and SM2 groups were 2.25 (95% confidence interval [CI] 1.04-4.83; P = 0.038) and 3.18 (95% CI 1.08-9.34; P = 0.036), respectively, compared to those in the EP/LPM group, while those for patients with a CCI ≥ 3 and PNI ≤ 47.75 were 3.25 (95% CI 1.79-5.89; P < 0.001) and 2.42 (95% CI 1.26-4.65; P = 0.008), respectively.


CONCLUSIONS
This study identified that invasion depth, presence of comorbid diseases and preoperative nutritional status are independent prognostic risk factors associated with ESCC patients undergoing ESD.
['Iwai|Naoto|N|http://orcid.org/0000-0002-6943-1605', 'Dohi|Osamu|O|http://orcid.org/0000-0002-0498-0144', 'Yamada|Shinya|S|', 'Harusato|Akihito|A|', 'Horie|Ryusuke|R|', 'Yasuda|Takeshi|T|', 'Yamada|Nobuhisa|N|', 'Horii|Yusuke|Y|', 'Majima|Atsushi|A|', 'Zen|Keika|K|', 'Kimura|Hiroyuki|H|', 'Yagi|Nobuaki|N|', 'Naito|Yuji|Y|', 'Itoh|Yoshito|Y|']
Esophageal squamous cell carcinoma Endoscopic submucosal dissection Charlson Comorbidity Index Prognostic nutritional index Prognostic factors