Microsatellite Instability and Life Style Factors in Sporadic Colorectal Cancer.
BACKGROUND
Colorectal cancer (CRC) in Egypt is a relatively high young onset disease. As a form of heterogeneous cancer, there is interplay between genetic and environmental factors. We aimed at probing the association of life style factors and Microsatellite Instability (MSI) status that could provide more insights on carcinogenic process of CRC.


METHODS
One hundred incident sporadic CRC patients were involved. Information on risk factors of CRC was obtained and microsatellite instability status was predicted through evaluation of MMR protein expression via immunohistochemistry (IHC).


RESULTS
Median age was 47.50 years, females represented 54.0% and 36% of patients were Microsatellite Instability High (MSI-H). Most patients with right sided colon cancer (78.3%) were MSI-H while mostly stable or low MSS/MSI-L for left-sided colon and rectum (78.6%, 74.3% respectively, p<0.001). Patients with low physical activity had higher risk of MSS/MSI-L than those with moderate or high activity p =0.026. Patients with BMI greater than 30 Kg/m2 had higher MSS/MSI-L (75.5%) than those with BMI between 25-30 Kg/m2 (60.6%) and those with normal BMI.
['Atef|Nora|N|', 'Alieldin|Nelly|N|', 'Sherif|Ghada|G|', 'Loay|Iman|I|', 'Mostafa Mahmoud|Ahmed|A|', 'Mohamed|Ghada|G|']
D002288:Adenocarcinoma, Mucinous D000328:Adult D000368:Aged D000369:Aged, 80 and over D018279:Carcinoma, Signet Ring Cell D015179:Colorectal Neoplasms D004534:Egypt D005260:Female D005500:Follow-Up Studies D006801:Humans D008019:Life Style D008297:Male D053842:Microsatellite Instability D008875:Middle Aged D011379:Prognosis D055815:Young Adult
CRC egyption MSI physical activity BMI