Analysis of second-line chemotherapies for ductal pancreatic adenocarcinoma in a German single-center cohort.
Pancreatic ductal adenocarcinoma (PDAC) is the third most common tumor of the gastrointestinal tract. At the time of diagnosis, the majority of PDACs shows already metastasis and does not qualify for curative surgery. Therefore, palliative chemotherapy has a very high priority, but recommendations after failure of first-line chemotherapies are quite limited. The aim of our analysis was to evaluate the efficacy of different second-line treatments after pretreatment with gemcitabine (57.5%), gemcitabine + erlotinib (25%), and platinum-based chemotherapy (17.5%). We included all patients with advanced PDAC treated with second-line chemotherapy in our department between 2005 and 2012. A total of 22 patients were treated with XELOX, 8 patients with FOLFOX, 6 patients with gemcitabine (+/- erlotinib) and 4 patients with FOLFIRI. On average, the patients received 4.2 cycles (standard deviation [SD] SD: 3.5) over a period of 2.5 months (SD: 2.6). The median overall survival (OS) for all patients was 5.4 months, progression-free survival was 3.5 months, and a tumor control was achieved in 21% of all cases. Toxicity profile was acceptable between the second-line chemotherapies and there was no significant difference in the other investigated end points. Interestingly, there was also no effect of the first-line treatment and their duration for the OS of the second-line therapy. According to our findings, second-line chemotherapies in advanced PDAC are beneficial and should be offered to patients, but we did not detect any superiority of a specific drug combination. More prospective, randomized and larger studies are necessary to evaluate new strategies for second-line chemotherapies.
['Maier-Stocker|Constantin|C|', 'Bitzer|Michael|M|', 'Malek|Nisar P|NP|', 'Plentz|Ruben R|RR|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D000970:Antineoplastic Agents D000971:Antineoplastic Combined Chemotherapy Protocols D002166:Camptothecin D000069287:Capecitabine D021441:Carcinoma, Pancreatic Ductal D003841:Deoxycytidine D004334:Drug Administration Schedule D000069347:Erlotinib Hydrochloride D005260:Female D005472:Fluorouracil D006801:Humans D002955:Leucovorin D008297:Male D008875:Middle Aged D009944:Organoplatinum Compounds D010071:Oxaloacetates D010166:Palliative Care D010190:Pancreatic Neoplasms D011799:Quinazolines D012189:Retrospective Studies D016019:Survival Analysis D016896:Treatment Outcome
chemotherapy pancreatic ductal adenocarcinoma survival side effects