Changing Trends in Gastric Polyps.
Background
The prevalence of gastric polyps varies around the world reflecting regional associations. We describe demographic features of patients with gastric polyp diagnosis treated between 1980 and 2016 at a referral center in Mexico City and analyzed trends of polyp subtype.


Materials and Methods
We conducted a blind review of archival slides of gastric biopsies with polyp diagnosis from the years 1980, 1990, 2000, 2010, and 2016. Initial diagnosis; patient's gender, age and symptoms; and number and location of lesions were recorded. Blind slide review and trend analysis were performed.


Results
In 3887 gastric biopsies, 192 patients (4.93%) with epithelial polyps were identified. The median age of patients was 58 years; 73% were female. Polyps were single in 143/192 cases (74.4%), almost 67% in the oxyntic mucosa, and 85% were associated with dyspepsia. The prevalence was 0.5%, 1.6%, 1.9%, 4.6%, and 9.6% for the years 1980, 1990, 2000, 2010, and 2016, respectively, resulting in a rising trend in the prevalence of epithelial polyps of 380% in 46 years. Fundic gland polyps (FGPs) had a global frequency of 66.6% (128/192). They were identified for the first time in the third period of the study, with a frequency of 28.6% (6/21), 66.6% (35/53), and 78.3% (87/111) for the years 2000, 2010, and 2016, respectively. Contrary, hyperplastic polyps (HPs) decreased 20%. A relative prevalence of 3.29%, 0.97%, and 0.15% was observed for FGP, HP, and gastric adenoma, respectively.


Discussion
The 1400% change of FGP explains the increased prevalence of gastric polyps. Chronic treatment with proton pump inhibitors and Helicobacter pylori eradication are possible explanations.
['Velázquez-Dohorn|Magali Evangelina|ME|', 'López-Durand|Carlos Fernando|CF|', 'Gamboa-Domínguez|Armando|A|']
D000236:Adenoma D000328:Adult D000368:Aged D000369:Aged, 80 and over D001706:Biopsy D004415:Dyspepsia D005260:Female D005748:Gastric Fundus D006801:Humans D008297:Male D008800:Mexico D008875:Middle Aged D011127:Polyps D015995:Prevalence D013274:Stomach Neoplasms D055815:Young Adult
Gastric polyp Prevalence Mexico Fundic gland polyp Hyperplastic polyp Gastric adenoma Time trend