Complement in removal of the dead - balancing inflammation.
Recognition and removal of apoptotic and necrotic cells must be efficient and highly controlled to avoid excessive inflammation and autoimmune responses to self. The complement system, a crucial part of innate immunity, plays an important role in this process. Thus, apoptotic and necrotic cells are recognized by complement initiators such as C1q, mannose binding lectin, ficolins, and properdin. This triggers complement activation and opsonization of cells with fragments of C3b, which enhances phagocytosis and thus ensures silent removal. Importantly, the process is tightly controlled by the binding of complement inhibitors C4b-binding protein and factor H, which attenuates late steps of complement activation and inflammation. Furthermore, factor H becomes actively internalized by apoptotic cells, where it catalyzes the cleavage of intracellular C3 to C3b. The intracellularly derived C3b additionally opsonizes the cell surface further supporting safe and fast clearance and thereby aids to prevent autoimmunity. Internalized factor H also binds nucleosomes and directs monocytes into production of anti-inflammatory cytokines upon phagocytosis of such complexes. Disturbances in the complement-mediated clearance of dying cells result in persistence of autoantigens and development of autoimmune diseases like systemic lupus erythematosus, and may also be involved in development of age-related macula degeneration.
['Martin|Myriam|M|', 'Blom|Anna M|AM|']
D000818:Animals D017209:Apoptosis D003167:Complement Activation D017242:Complement Factor H D003165:Complement System Proteins D006801:Humans D007113:Immunity, Innate D007249:Inflammation D008180:Lupus Erythematosus, Systemic D009000:Monocytes D009336:Necrosis D010587:Phagocytosis
complement system factor H clearance systemic lupus erythematosus apoptosis intracellular complement