Sialendoscopy enhances salivary gland function in Sjögren's syndrome: a 6-month follow-up, randomised and controlled, single blind study.
OBJECTIVES
To assess the effect of sialendoscopy of the major salivary glands on salivary flow and xerostomia in patients with Sjögren's syndrome (SS).


METHODS
Forty-nine patients with SS were randomly assigned to a control group (n=15) and two intervention groups: irrigation of the major glands with saline (n=16) or with saline followed by triamcinolone acetonide (TA) in saline (n=18). Unstimulated whole saliva flow (UWS), chewing-stimulated whole saliva flow (SWS), citric acid-stimulated parotid flow (SPF), Clinical Oral Dryness Score (CODS), Xerostomia Inventory (XI) score and the European League Against Rheumatism (EULAR) SS Patient-Reported Index (ESSPRI) were obtained 1 week (T0) before, and 1 (T1), 8 (T8), 16 (T16) and 24 (T24) weeks after sialendoscopy.


RESULTS
Median baseline UWS, SWS and SPF scores were 0.14, 0.46 and 0.22 mL/min, respectively. After intervention, significant increases in UWS and SWS were observed in the saline group (at T8 (P=0.013) and T24 (P=0.004)) and the saline/TA group (at T24 (P=0.03) and T=16 (P=0.035)). SPF was increased significantly in the saline/TA group at T24 (P=0.03). XI scores declined after sialendoscopy in both intervention groups. Compared with the control group, CODS, XI and ESSPRI improved in the intervention groups. UWS, SWS and SPF were higher in the intervention groups compared with the control group, but these differences were not significant except for SPF in the saline/TA group at T24 (P=0.005).


CONCLUSIONS
Irrigation of the major salivary glands in patients with SS enhances salivary flow and reduces xerostomia up to 6 months after sialendoscopy.
['Karagozoglu|K Hakki|KH|', 'Vissink|Arjan|A|', 'Forouzanfar|Tim|T|', 'Brand|Henk S|HS|', 'Maarse|Floor|F|', 'Jager|Derk Hendrik Jan|DHJ|0000-0002-3006-2128']
D000328:Adult D004724:Endoscopy D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D020127:Recovery of Function D012016:Reference Values D000077330:Saline Solution D012463:Saliva D012469:Salivary Glands D012472:Salivation D012720:Severity of Illness Index D016037:Single-Blind Method D012859:Sjogren's Syndrome D007507:Therapeutic Irrigation D016896:Treatment Outcome D014221:Triamcinolone D014987:Xerostomia
Sjøgren’s syndrome corticosteroids treatment