Recent progress in the design fabrication of metal-organic frameworks-based nanozymes and their applications to sensing and cancer therapy.
The nanomaterials with enzyme-like catalytic activity, named as nanozymes, have aroused wide research interest owing to their striking merits. Metal-organic frameworks (MOFs) have showed great prospect in the construction of novel nanozymes. In this review, firstly, we summarize the most recent contributions in the design construction of the MOFs-based nanozymes. Then, we concentrate our attention on their applications in the fields of sensing and cancer therapies. According to the design strategies, we categorized MOFs-based nanozymes into four classes for review (i.e. pristine MOFs, MOFs with modification, MOFs-based nanocomposites, and MOF derivatives). Meanwhile, the emerging and fascinating 2D MOFs-based nanozymes were also reviewed. A variety of novel applications are also discussed, including nanozymes catalytic mediated signal amplification in sensing applications (e.g. colorimetric sensing, fluorescent sensing, chemiluminescent sensing, electrochemical sensing, and surface-enhanced Raman scattering (SERS)), and nanozymes catalytic mediated cancer therapy (i.e. cancer-starvation therapy, enhancing photodynamic therapy, and cancer-starvation and PDT synergistic therapy). At the end of the article, future opportunities and challenges in this promising research area are tentatively proposed.
['Zhang|Xianlong|X|', 'Li|Guoliang|G|', 'Wu|Di|D|', 'Li|Xiuling|X|', 'Hu|Na|N|', 'Chen|Jian|J|', 'Chen|Guang|G|', 'Wu|Yongning|Y|']
D015374:Biosensing Techniques D003124:Colorimetry D006801:Humans D000073396:Metal-Organic Frameworks D053761:Nanocomposites D009369:Neoplasms D013059:Spectrum Analysis, Raman
Nanozyme Metal-organic frameworks (MOFs) Cancer-starvation therapy Enhancing photodynamic therapy Synergistic therapy Sensing method