Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes.
Adiponectin, an adipose tissue-derived hormone, plays integral roles in lipid and glucose metabolism in peripheral tissues, such as the skeletal muscle, adipose tissue, and liver. Moreover, it has also been shown to have an impact on metabolic processes in the central nervous system. Astrocytes comprise the most abundant cell type in the central nervous system and actively participate in metabolic processes between blood vessels and neurons. However, the ability of adiponectin to control nutrient metabolism in astrocytes has not yet been fully elucidated. In this study, we investigated the effects of adiponectin on multiple metabolic processes in hypothalamic astrocytes. Adiponectin enhanced glucose uptake, glycolytic processes and fatty acid oxidation in cultured primary hypothalamic astrocytes. In line with these findings, we also found that adiponectin treatment effectively enhanced synthesis and release of monocarboxylates. Overall, these data suggested that adiponectin triggers catabolic processes in astrocytes, thereby enhancing nutrient availability in the hypothalamus.
['Song|Nuri|N|', 'Jeong|Da Yeon|DY|', 'Tu|Thai Hien|TH|', 'Park|Byong Seo|BS|', 'Yang|Hye Rim|HR|', 'Kim|Ye Jin|YJ|0000-0002-9743-8513', 'Kim|Jae Kwang|JK|0000-0003-2692-5370', 'Park|Joon Tae|JT|', 'Yeh|Jung-Yong|JY|0000-0002-0939-7783', 'Yang|Sunggu|S|', 'Kim|Jae Geun|JG|']
D052242:Adiponectin D000818:Animals D001253:Astrocytes D004734:Energy Metabolism D005260:Female D005947:Glucose D006019:Glycolysis D007031:Hypothalamus D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D000078622:Nutrients D010084:Oxidation-Reduction
adiponectin astrocyte hypothalamus energy metabolism glycolysis metabolic diseases