Management of multicentric paragangliomas: Review of 24 patients with 60 tumors.
BACKGROUND
The purpose of this study was to reflect our experience in the management of multicentric head and neck paragangliomas, including genetic study and counseling, diagnostic tools, types of treatment, and the need for monitoring.


METHODS
A retrospective review of 24 patients with multicentric paraganglioma, including a total of 60 paragangliomas: 37 carotid body tumors, 13 jugulotympanic paragangliomas, and 10 vagal paragangliomas.


RESULTS
A total of 26 surgical procedures were performed, including the resection of 36 paragangliomas. Four tumors were pending surgery at the time of this review. Radiotherapy was administered in 7 patients with 9 tumors. A "wait-and-scan" policy with periodic MRI imaging tests was instituted for 9 patients with 12 paragangliomas.


CONCLUSION
The knowledge of the different modalities of management is especially relevant in patients with multicentric paragangliomas. In every case, benefits and potential risks of all treatment options may be taken into consideration for every individual patient.
['Álvarez-Morujo|Ricardo J González-Orús|RJ|', 'Ruiz|Miguel Ángel Arístegui|MÁ|', 'Serafini|Daniel Poletti|DP|', 'Delgado|Irene López|IL|', 'Friedlander|Eviatar|E|', 'Yurrita|Bartolomé Scola|BS|']
D000328:Adult D000368:Aged D020209:Cranial Nerve Injuries D005260:Female D006258:Head and Neck Neoplasms D006801:Humans D008297:Male D008875:Middle Aged D009154:Mutation D010236:Paraganglioma, Extra-Adrenal D011183:Postoperative Complications D012189:Retrospective Studies D013385:Succinate Dehydrogenase D057832:Watchful Waiting D055815:Young Adult
multicentric paraganglioma head and neck paraganglioma bilateral carotid body tumor hereditary paraganglioma multifocal glomus