T cell engaging bispecific antibody (T-BsAb): From technology to therapeutics.
Harnessing the power of the human immune system to treat cancer is the essence of immunotherapy. Monoclonal antibodies engage the innate immune system to destroy targeted cells. For the last 30years, antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity have been the main mechanisms of anti-tumor action of unconjugated antibody drugs. Efforts to exploit the potentials of other immune cells, in particular T cells, culminated in the recent approval of two T cell engaging bispecific antibody (T-BsAb) drugs, thereby stimulating new efforts to accelerate similar platforms through preclinical and clinical trials. In this review, we have compiled the worldwide effort in exploring T cell engaging bispecific antibodies. Our special emphasis is on the lessons learned, with the hope to derive insights in this fast evolving field with tremendous clinical potential.
['Wu|Z|Z|', 'Cheung|N V|NV|']
D000818:Animals D018033:Antibodies, Bispecific D006801:Humans D007113:Immunity, Innate D008954:Models, Biological D009369:Neoplasms D013602:T-Lymphocytes, Cytotoxic
T cell engaging bispecific antibodies Bispecific antibodies Bivalent CD3 binding Cancer immunotherapy Potency of bispecific antibodies TDCC