Synthesis of multi-functionalized benzofurans through the condensation of ninhydrin and phenols using SSA as a recyclable heterogeneous acid catalyst.
A simple and efficient one-pot methodology has been developed for the synthesis of biologically important multi-functionalized 3-(2[Formula: see text]-hydroxyaryl)-2-(2[Formula: see text]-carboxyphenyl)benzofurans using silica sulfuric acid (SSA) as a heterogeneous acid catalyst in DMF medium. The significant advantages of this methodology are the use of SSA as a recyclable solid acid catalyst, operational simplicity, easy availability of the starting materials, and good yield of the products with high atom-economy.
['Kundu|Ashis|A|', 'Pramanik|Animesh|A|']
D001572:Benzofurans D002384:Catalysis D060326:Chemistry Techniques, Synthetic D015394:Molecular Structure D009555:Ninhydrin D010636:Phenols D012822:Silicon Dioxide D013464:Sulfuric Acids
Benzofurans Ninhydrin Phenols Silica sulfuric acid Condensation reaction