Terminalia arjuna gum/alginate in situ gel system with prolonged retention time for ophthalmic drug delivery.
Poor availability is the major barrier to accept the new smart gel system as a preferred ophthalmic solution for various eye problems. Smart gel system especially derived from natural source allows the rapid transition of ocular solution into gel form upon contact to tear solution. The present experimental scheme was intended to prepare and characterize a pH triggered in situ gelling system using moxifloxacin HCl (MOX-HCl). Gum was extracted from Terminalia arjuna bark resin and used as gelling agent in blend with sodium alginate. Sterilized formulations were developed and characterized for their physicochemical attributes. These were further investigated for microbiological testing and eye irritation studies. Drug loaded in situ gel was appeared as clear sol that converted into gel phase in presence of tear solution. Optimized formulation was stable, therapeutically efficacious, non-irritant and has a sustained release of the drug for twelve hours period. Instillation of MOX-HCl loaded in situ gel did not cause any type of irritation symptoms like redness, inflammation and excessive tear production in rabbits as compared to control. MOX-HCl loaded in situ gel can be appraised as a substitute for conventional eye drops for extended precorneal retention, improved corneal permeability along with better ocular bioavailability.
['Noreen|Sobia|S|', 'Ghumman|Shazia Akram|SA|', 'Batool|Fozia|F|', 'Ijaz|Bushra|B|', 'Basharat|Maryam|M|', 'Noureen|Shazia|S|', 'Kausar|Tusneem|T|', 'Iqbal|Shahid|S|']
D060433:Administration, Ophthalmic D000464:Alginates D000818:Animals D001682:Biological Availability D045744:Cell Line, Tumor D002626:Chemistry, Pharmaceutical D003315:Cornea D003692:Delayed-Action Preparations D016503:Drug Delivery Systems D005782:Gels D006801:Humans D006863:Hydrogen-Ion Concentration D061986:MCF-7 Cells D009883:Ophthalmic Solutions D011817:Rabbits D029766:Terminalia D014783:Viscosity
Alginate Ophthalmic Drug delivery In situ gelling system Moxifloxacin Natural gum