First Direct Observation of Stable Internally Ordered Janus Nanoparticles Created by Lipid Self-Assembly.
We present the first observation of Janus nanoparticles consisting of stable, coexisting ordered mesophases in discrete particles created by lipid self-assembly. Cryo-TEM images provided visual identification of the multicompartment Janus nanoparticles and, combined with SAXS data, confirmed the presence of mixed cubic phases and mixed cubic/hexagonal phases within individual nanoparticles. We further investigated computer visualization models to interpret the potential interface between the interconnected coexisting nanostructured domains within a single nanoparticle.
['Tran|Nhiem|N|', 'Mulet|Xavier|X|', 'Hawley|Adrian M|AM|', 'Conn|Charlotte E|CE|', 'Zhai|Jiali|J|', 'Waddington|Lynne J|LJ|', 'Drummond|Calum J|CJ|']
Janus nanoparticles lipid self-assembly cubosome hexosome lyotropic liquid crystal polymorphism