Analgesic effects and structural elucidation of two new flavone C-glycosides from Artemisa sacrorum.
The present study was designed to isolate and characterize the analgesic compounds of Artemisa sacrorum Ledeb. The EtOAc crude extracts from the aerial parts of Artemisa sacrorum Ledeb were separated by chromatography and the structures of new compounds were elucidated based on spectral analyses. Analgesic activities of the isolated compounds were assessed in rats with hot plate test and paw pressure assay. Two new flavone C-glycosides, named as Sacroroside A and B (Compounds 1 and 2) were isolated from the EtOAc crude extract of the aerial parts ofArtemisa sacrorum Ledeb. They showed significant analgesic effects. In conclusion, Compounds 1 and 2 are new natural products, which show significant analgesic effects in a dose-dependent manner.
['Wang|Qing-Hu|QH|', 'Han|Na-Ren-Chao-Ke-Tu|NR|', 'Dai|Na-Yin-Tai|NY|', 'Wu|Rong-Jun|RJ|', 'Wu|Jie-Si|JS|']
D000700:Analgesics D000818:Animals D019306:Artemisia D004187:Disaccharides D044950:Flavanones D047309:Flavones D006358:Hot Temperature D008297:Male D015394:Molecular Structure D010146:Pain D008517:Phytotherapy D035261:Plant Components, Aerial D010936:Plant Extracts D011312:Pressure D017208:Rats, Wistar
Analgesic effect Artemisa sacrorum Ledeb Sacroroside A Sacroroside B