Methods of Inducing Inflammatory Bowel Disease in Mice.
Animal models of experimentally induced inflammatory bowel disease (IBD) are useful for understanding more about the mechanistic basis of the disease, identifying new targets for therapeutic intervention, and testing novel therapeutics. This unit provides detailed protocols for five widely used mouse models of experimentally induced intestinal inflammation: chemical induction of colitis by dextran sodium sulfate (DSS), hapten-induced colitis via 2,4,6-trinitrobenzene sulfonic acid (TNBS), Helicobacter-induced colitis in mdr1a(-/-) mice, the CD4(+) CD45RB(hi) SCID transfer colitis model, and the IL-10(-/-) colitis model. © 2016 by John Wiley & Sons, Inc.
['Bang|Byoungwook|B|', 'Lichtenberger|Lenard M|LM|']
D000818:Animals D003092:Colitis D016264:Dextran Sulfate D004195:Disease Models, Animal D005260:Female D007249:Inflammation D015212:Inflammatory Bowel Diseases D016753:Interleukin-10 D008297:Male D051379:Mice D008807:Mice, Inbred BALB C D008810:Mice, Inbred C57BL D016513:Mice, SCID D014301:Trinitrobenzenes D014302:Trinitrobenzenesulfonic Acid
model IBD mouse colitis