A versatile and highly efficient method for 1-chlorination of terminal and trialkylsilyl-protected alkynes.
A highly efficient one-pot procedure for the preparation of 1-chloroalkynes and 1-chlorobutadiynes from terminal and trialkylsilyl-protected precursors is reported. This convenient reaction, proceeding under mild conditions, utilizes N-chlorosuccinimide as the chlorinating agent and tolerates a range of functional groups.
['Gulia|Nurbey|N|', 'Pigulski|Bartłomiej|B|', 'Charewicz|Marta|M|', 'Szafert|Sławomir|S|']
D000480:Alkynes D002713:Chlorine D054879:Halogenation D015394:Molecular Structure D013388:Succinimides D014297:Trimethylsilyl Compounds
chlorine 1-haloalkynes halogenation silanes synthetic methods