Synthesis and antiproliferative activity of new 2-glyco-3-nitro-2H-chromenes.
3-nitro-2H-chromenes and derivatives are compounds with diverse biological activity, among them, new 2-glyco-3-nitro-2H-chromenes have been prepared by one-pot oxa-Michael-Henry-dehydration reactions between carbohydrate-derived nitroalkenes and several salicylaldehydes, using a minimal amount of solvent and DBU as catalyst. The antiproliferative activity of these new compounds has been evaluated against a panel of six human solid tumor cell lines, and compared to pharmacological reference compounds, finding that their activities are in the low micromolar range and that some of them are more effective than the standards.
['Luque-Agudo|Verónica|V|', 'Albarrán-Velo|Jesús|J|', 'Light|Mark E|ME|', 'Padrón|José M|JM|', 'Román|Emilio|E|', 'Serrano|José A|JA|', 'Gil|M Victoria|MV|']
D000970:Antineoplastic Agents D001578:Benzopyrans D045744:Cell Line, Tumor D049109:Cell Proliferation D004305:Dose-Response Relationship, Drug D004354:Drug Screening Assays, Antitumor D006801:Humans D015394:Molecular Structure D013329:Structure-Activity Relationship
Antiproliferative activity 3-nitro-2H-chromenes Carbohydrates Structure-activity relationship