CCR5 Promoter Polymorphism -2459G > A: Forgotten or Ignored?
C-C chemokine receptor 5 (CCR5) polymorphisms, particularly a 32-base pair deletion (∆32) in the open reading frame and -2459G > A in the promoter, are well known for their associations with HIV-1 infection and/or disease progression in a variety of studies. In this era of an HIV cure, where all the emphasis is on ∆32, it seems that -2459G > A has been forgotten or ignored. There is significant importance in the incorporation of the CCR5 -2459G > A genotype information into studies evaluating new immunologic and chemotherapeutic strategies, and those designing and implementing better treatment strategies with current antiretroviral therapy, doing so would enable a better understanding of the response to the intervention, due to a mechanistic or constitutive explanation. Until we find a strategy, whether a stem-cell transplantation or CCR5 editing approach or something else, that delivers a cure to the millions, we should make use of every piece of information that may help curtail HIV/AIDS as a threat to public health.
['Mehlotra|Rajeev K|RK|']
D019380:Anti-HIV Agents D018450:Disease Progression D000072669:Gene Editing D020022:Genetic Predisposition to Disease D005820:Genetic Testing D015316:Genetic Therapy D015658:HIV Infections D006801:Humans D020641:Polymorphism, Single Nucleotide D011401:Promoter Regions, Genetic D019713:Receptors, CCR5 D016896:Treatment Outcome
CCR5 promoter polymorphism HIV cure Delta32 haplotype host genetics −2459G > A