Rat Blood Leukocytes after Intravenous Injection of Chitosan-Modified Magnetic Nanospheres.
Nanosized magnetite particles (magnetic nanospheres) are a prospective basis for creation of new diagnostic and therapeutic agents. The structure of blood leukocytes and the leukocytic formula are studied in adult rats over a period of 120 days after a single intravenous injection of chitosan-modified nanosized magnetite particles. No effects of chitosan-modified magnetic nanospheres on the structure of rat blood leukocytes are detected. Injection of suspension of chitosan-modified magnetite nanospheres is associated with an increase in the levels of monocytes, segmented and stab neutrophils, and a decrease in lymphocyte counts in the blood of rats. The shifts in the leukogram parameters are transitory, the picture returned to normal by day 40 postinjection.
['Milto|I V|IV|', 'Ivanova|V V|VV|', 'Shevtsova|N M|NM|', 'Sukhodolo|I V|IV|']
D000818:Animals D021461:Animals, Outbred Strains D048271:Chitosan D007275:Injections, Intravenous D007958:Leukocyte Count D008214:Lymphocytes D058185:Magnetite Nanoparticles D008297:Male D009000:Monocytes D054118:Nanospheres D009504:Neutrophils D010316:Particle Size D051381:Rats
leukocytes magnetite nanospheres chitosan magnetite nanoparticles