Quality of life, patient satisfaction, and disease burden in patients with gastroesophageal reflux disease with or without laryngopharyngeal reflux symptoms.
BACKGROUND AND AIM
Patients with gastroesophageal reflux disease (GERD) have decreased health-related quality of life (HRQL). The quality of life in patients with laryngopharyngeal reflux (LPR) symptoms is also significantly impaired. However, the impact of LPR symptoms on HRQL in GERD patients has not been studied.


METHODS
A nationwide, random-sample, and face-to-face survey of 300 Korean patients with GERD was conducted from January to March 2013. Gastroesophageal reflux symptoms were assessed using the Rome III questionnaire, LPR symptoms using the reflux symptom index, and HRQL using the EuroQol five dimensions (EQ-5D) questionnaire. A structured questionnaire on patient satisfaction, sickness-related absences, and health-related work productivity was also used.


RESULTS
Among the 300 patients with GERD, 150 had LPR symptoms. The mean EQ-5D index was lower in patients with GERD and LPR symptoms than in those without LPR (0.88 vs 0.91, P = 0.002). A linear regression model showed that the severity of LPR symptoms was related to decreased HRQL and was independent of age, marital status, body mass index, or household income. The overall satisfaction rate regarding treatment was lower in patients with GERD and LPR (40.0% vs 69.1%, P = 0.040). GERD patients with LPR symptoms reported greater sickness-related absent hours per week (0.36 vs 0.02 h, P = 0.016) and greater percentages of overall work impairment than those without LPR (31.1% vs 20.8%, P < 0.001).


CONCLUSIONS
Gastroesophageal reflux disease patients with LPR symptoms have a poorer HRQL, a lower satisfaction rate, and a greater disease burden than those without LPR.
['Gong|Eun Jeong|EJ|', 'Choi|Kee Don|KD|', 'Jung|Hye-Kyung|HK|', 'Youn|Young Hoon|YH|', 'Min|Byung-Hoon|BH|', 'Song|Kyung Ho|KH|http://orcid.org/0000-0001-6661-3879', 'Huh|Kyu Chan|KC|']
D000041:Absenteeism D000328:Adult D044466:Asians D017281:Cost of Illness D005260:Female D005764:Gastroesophageal Reflux D006801:Humans D016014:Linear Models D008297:Male D008875:Middle Aged D017060:Patient Satisfaction D011788:Quality of Life D012720:Severity of Illness Index D011795:Surveys and Questionnaires D000066477:Work Performance
quality of life gastroesophageal reflux disease laryngopharyngeal reflux