Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's disease.
Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation.
['Vural|Burçak|B|', 'Sehitoğlu|Elçin|E|', 'Cavuş|Filiz|F|', 'Yalçınkaya|Nazlı|N|', 'Haytural|Hazal|H|', 'Küçükerden|Melike|M|', 'Ulusoy|Canan|C|', 'Uğurel|Elif|E|', 'Turan|Selin|S|', 'Bulut|Leyla|L|', 'Türkoğlu|Recai|R|', 'Shugaiv|Erkingül|E|', 'Kürtüncü|Murat|M|', 'Atakan|Sükrü|S|', 'Güre|Ali O|AO|', 'Gül|Ahmet|A|', 'Eraksoy|Mefkure|M|', 'Akman-Demir|Gülşen|G|', 'Tüzün|Erdem|E|']
D000328:Adult D000818:Animals D001323:Autoantibodies D001528:Behcet Syndrome D015415:Biomarkers D005260:Female D006801:Humans D008297:Male D008565:Membrane Proteins D024101:Mitochondrial Proteins D009707:Nucleosomes D051381:Rats
Mitochondrial carrier homolog 1 Antibody Neuro-Behçet's disease Anti-neuronal antibody Autoimmunity Behçet's disease