In vitro study to evaluate the cytotoxicity of BPA analogues based on their oxidative and genotoxic potential using human peripheral blood cells.
Although Bisphenol-A (BPA) has been found to exhibit toxicological properties such as genotoxicity and oxidative stress, yet there is very little data available on its analogues. Since the replacement of BPA by its analogues, their presence has been found to increase in the environment leading to increased human exposure that makes it essential to investigate their toxic effects. Therefore, we explored the genotoxic and oxidative potential of two common BPA analogues, Bisphenol-B (BPB) and Bisphenol-F (BPF). Both analogues were found to induce cytotoxicity in human peripheral blood cells. They also caused an increase in reactive oxygen species levels leading to a decrease in GSH and an increase in LPO levels. Comet assay also suggested them to be genotoxic. Therefore, bisphenols were found capable of inducing cytotoxicity via oxidative stress and genotoxicity.
['Ikhlas|Shoeb|S|', 'Usman|Afia|A|', 'Ahmad|Masood|M|']
D000328:Adult D001559:Benzhydryl Compounds D002470:Cell Survival D002478:Cells, Cultured D020552:Comet Assay D004249:DNA Damage D005978:Glutathione D006801:Humans D007963:Leukocytes, Mononuclear D009153:Mutagens D018384:Oxidative Stress D010636:Phenols D017382:Reactive Oxygen Species
Genotoxic Bisphenol-A Oxidative stress Bisphenol-B Bisphenol-F