miR-137 inhibits glutamine catabolism and growth of malignant melanoma by targeting glutaminase.
Glutamine catabolism is considered to be an important metabolic pathway for cancer cells. Glutaminase (GLS) is the important rate-limiting enzyme of glutamine catabolism. miR-137 functions as a tumor suppressor in many human malignant tumors. However, the role and molecular mechanism of miR-137 and GLS in malignant melanoma has not been reported. In this study, we showed that miR-137 was decreased in melanoma tissue, and the low miR-137 level and high GLS expression are independent risk factor in melanoma. miR-137 suppressed the proliferation and glutamine catabolism of melanoma cells. GLS is crucial for glutamine catabolism and growth of malignant melanoma. We also demonstrated that miR-137 acts as a tumor suppressor in melanoma by targeting GLS. This result elucidates a new mechanism for miR-137 in melanoma development and provides a survival indicator and potential therapeutic target for melanoma patients.
['Luan|Wenkang|W|', 'Zhou|Zhou|Z|', 'Zhu|Yan|Y|', 'Xia|Yun|Y|', 'Wang|Jinlong|J|', 'Xu|Bin|B|']
D000818:Animals D045744:Cell Line, Tumor D049109:Cell Proliferation D005972:Glutaminase D005973:Glutamine D064593:Heterografts D006801:Humans D008545:Melanoma D051379:Mice D008819:Mice, Nude D035683:MicroRNAs D011379:Prognosis D012878:Skin Neoplasms
miR-137 Glutamine catabolism Growth Melanoma GLS