Molecular biology and immunology of head and neck cancer.
In recent years, our knowledge and understanding of head and neck squamous cell carcinoma (HNSCC) has expanded dramatically. New high-throughput sequencing technologies have accelerated these discoveries since the first reports of whole-exome sequencing of HNSCC tumors in 2011. In addition, the discovery of human papillomavirus in relationship with oropharyngeal squamous cell carcinoma has shifted our molecular understanding of the disease. New investigation into the role of immune evasion in HNSCC has also led to potential novel therapies based on immune-specific systemic therapies.
['Guo|Theresa|T|', 'Califano|Joseph A|JA|']
D006258:Head and Neck Neoplasms D006801:Humans D008967:Molecular Biology D058990:Molecular Targeted Therapy D027383:Papillomaviridae D030361:Papillomavirus Infections D011379:Prognosis D012307:Risk Factors
Molecular biology Immunology Head and neck cancer Targeted therapy