Influence of low-intensity pulsed ultrasound on osteogenic tissue regeneration in a periodontal injury model: X-ray image alterations assessed by micro-computed tomography.
OBJECTIVE
This study was conducted to evaluate, with micro-computed tomography, the influence of low-intensity pulsed ultrasound on wound-healing in periodontal tissues.


METHODS
Periodontal disease with Class II furcation involvement was surgically produced at the bilateral mandibular premolars in 8 adult male beagle dogs. Twenty-four teeth were randomly assigned among 4 groups (G): G1, periodontal flap surgery; G2, periodontal flap surgery+low-intensity pulsed ultrasound (LIPUS); G3, guided tissue regeneration (GTR) surgery; G4, GTR surgery plus LIPUS. The affected area in the experimental group was exposed to LIPUS. At 6 and 8weeks, the X-ray images of regenerated teeth were referred to micro-CT scanning for 3-D measurement.


RESULTS
Bone volume (BV), bone surface (BS), and number of trabeculae (Tb) in G2 and G4 were higher than in G1 and G3 (p<0.05). BV, BS, and Tb.N of the GTR+LIPUS group were higher than in the GTR group. BV, BS, and Tb.N of the LIPUS group were higher than in the periodontal flap surgery group.


CONCLUSION
LIPUS irradiation increased the number, volume, and area of new alveolar bone trabeculae. LIPUS has the potential to promote the repair of periodontal tissue, and may work effectively if combined with GTR.
['Wang|Yunji|Y|', 'Chai|Zhaowu|Z|', 'Zhang|Yuanyuan|Y|', 'Deng|Feng|F|', 'Wang|Zhibiao|Z|', 'Song|Jinlin|J|']
D016301:Alveolar Bone Loss D000818:Animals D001861:Bone Regeneration D004285:Dogs D017823:Furcation Defects D048091:Guided Tissue Regeneration D021621:Imaging, Three-Dimensional D008297:Male D013524:Surgical Flaps D014464:Ultrasonic Therapy D014945:Wound Healing D055114:X-Ray Microtomography
Low-intensity pulsed ultrasound Micro-computed tomography Periodontal disease