Examining trends in prediabetes and its relationship with the metabolic syndrome in US adolescents, 1999-2014.
AIMS
We sought to investigate temporal trends in prediabetes prevalence among US adolescents using two definitions and evaluate relationships with obesity and a MetS-severity score.


METHODS
We evaluated data from 5418 non-Hispanic white, non-Hispanic black, and Hispanic adolescents aged 12-19 participating in the National Health and Nutrition Examination Survey 1999-2014 with complete data regarding MetS and hemoglobin A1c (HbA1c). Prediabetes status was defined by American Diabetes Association (ADA) criteria: fasting glucose 100-125 mg/dL or HbA1c 5.7%-6.4%. MetS severity was assessed with a MetS-severity Z-score.


RESULTS
Prevalence of prediabetes as defined by HbA1c abnormalities significantly increased from 1999-2014, while prevalence of prediabetes as defined by fasting glucose abnormalities showed no significant temporal trend. There were variations in these trends across different racial/ethnic groups. MetS Z-score was overall more strongly correlated with HbA1c, fasting insulin, and the homeostasis model of insulin resistance than was BMI Z-score. These correlations were true in each racial/ethnic group with the exception that in non-Hispanic white adolescents, in whom the MetS Z-score was not significantly correlated with HbA1c measurements.


CONCLUSION
We found conflicting findings of temporal trends of US adolescent prediabetes prevalence based on the ADA's prediabetes criteria. The increasing prevalence of prediabetes by HbA1c assessment is concerning and raises the urgency for increased awareness and appropriate measures of prediabetes status among physicians and patients.
['Lee|Arthur M|AM|', 'Fermin|Cyrelle R|CR|', 'Filipp|Stephanie L|SL|', 'Gurka|Matthew J|MJ|', 'DeBoer|Mark D|MD|']
D000293:Adolescent D001741:African Americans D002648:Child D005260:Female D006442:Glycated Hemoglobin A D006630:Hispanic or Latino D006801:Humans D007333:Insulin Resistance D008297:Male D024821:Metabolic Syndrome D009749:Nutrition Surveys D009765:Obesity D011236:Prediabetic State D015995:Prevalence D014481:United States D044465:Whites D055815:Young Adult
Prediabetes Metabolic syndrome Obesity Insulin resistance Type 2 diabetes mellitus