Modified Glasgow Prognostic Score is predictive of prognosis for non-small cell lung cancer patients treated with stereotactic body radiation therapy: a retrospective study.
We aimed to assess the predictive value of the modified Glasgow prognostic score (mGPS) in patients with non-small cell lung cancer (NSCLC) who underwent stereotactic body radiation therapy (SBRT). We retrospectively reviewed the records of 207 patients, with a median age of 79 years. The pretreatment mGPS was calculated and categorized as high (mGPS = 1-2) or low (mGPS = 0). The median follow-up duration was 40.7 months. The five-year overall survival (OS), progression-free survival (PFS) and time to progression (TTP) rates were 44.3%, 36% and 54.4%, respectively. Multivariate analysis revealed that mGPS was independently predictive of OS (hazard ratio [HR] 1.67; 95% confidence interval 1.14-2.44: P = 0.009), PFS (HR 1.58; 1.10-2.28: P = 0.014) and TTP (HR 1.66; 1.03-2.68: P = 0.039). Patients who had high mGPS showed significantly worse OS (33.3 vs 64.5 months, P = 0.003) and worse PFS (23.8 vs 39 months, P = 0.008) than those who had low mGPS. The data showed a trend that patients with high mGPS suffered earlier progression compared to those with low mGPS (54.3 vs 88.1 months, P = 0.149). We confirmed that mGPS is independently predictive of prognosis in NSCLC patients treated with SBRT.
['Chen|Zhe|Z|', 'Nonaka|Hotaka|H|', 'Onishi|Hiroshi|H|', 'Nakatani|Eiji|E|', 'Sato|Yoko|Y|', 'Funayama|Satoshi|S|', 'Watanabe|Hiroaki|H|', 'Komiyama|Takafumi|T|', 'Kuriyama|Kengo|K|', 'Marino|Kan|K|', 'Aoki|Shinichi|S|', 'Araya|Masayuki|M|', 'Tominaga|Licht|L|', 'Saito|Ryo|R|', 'Maehata|Yoshiyasu|Y|', 'Oguri|Mitsuhiko|M|', 'Saito|Masahide|M|']
D000368:Aged D000369:Aged, 80 and over D002289:Carcinoma, Non-Small-Cell Lung D005260:Female D006801:Humans D053208:Kaplan-Meier Estimate D008175:Lung Neoplasms D008297:Male D008875:Middle Aged D015999:Multivariate Analysis D011379:Prognosis D000077982:Progression-Free Survival D016016:Proportional Hazards Models D016634:Radiosurgery D012189:Retrospective Studies
prognosis modified Glasgow prognostic score (mGPS) non-small cell lung cancer (NSCLC) stereotactic body radiation therapy (SBRT) biological markers