Influence on serum asymmetric dimethylarginine (ADMA) concentrations of human paraoxonase 1 polymorphism (Q192R) and exposure to polycyclic aromatic hydrocarbons (PAHs) in Mexican women, a gene-environment interaction.
It has been demonstrated that Cardiovascular Diseases (CVD) are a consequence of the combination of genetic and environmental factors and/or the interaction between them. Therefore, the aim of this study was to evaluate the impact of polycyclic aromatic hydrocarbon (PAHs) exposure and PON1 Q192R polymorphism (genetic susceptibility) on serum asymmetric dimethylarginine (ADMA) levels in Mexican women (n = 206). Urinary 1-hydroxypyrene concentrations (1-OHP; exposure biomarker for PAHs) were quantified using a high-performance liquid chromatography technique, PON1 Q192R polymorphism was genotyped using TaqMan probes and serum ADMA concentrations were evaluated using a commercially available ELISA kit. Urinary 1-OHP levels detected in this study ranged from 0.07 to 9.37 μmol/mol of creatinine (0.13-18.0 μg/g of creatinine). Regarding allele frequency (PON1 Q192R polymorphism), the 192Q-allele frequency was 0.43 and for the 192R-allele it was 0.57. In relation to serum ADMA levels, the levels ranged from 0.06 to 1.46 μmol/L. Moreover, multiple linear regression analysis was performed and associations between urinary 1-OHP levels (β = 0.05, p = 0.002), PON1 Q192R polymorphism (β = 0.04, p = 0.003) and serum ADMA concentrations were found. Besides, an interaction (gene-environment interaction) of both independent variables (1-OHP and PON1 polymorphism) on serum ADMA levels was found (β = 0.04, p = 0.02) in the constructed multiple linear model. Therefore, according to the significance of this research, it is necessary to execute health programs to reduce cardiovascular risk in the assessed population.
['Ochoa-Martínez|Ángeles C|ÁC|', 'Ruíz-Vera|Tania|T|', 'Almendarez-Reyna|Claudia I|CI|', 'Orta-García|Sandra T|ST|', 'Pérez-Maldonado|Iván N|IN|']
D000328:Adult D000483:Alleles D001120:Arginine D043303:Aryldialkylphosphatase D015415:Biomarkers D002318:Cardiovascular Diseases D003404:Creatinine D004781:Environmental Exposure D004785:Environmental Pollutants D005260:Female D005787:Gene Frequency D059647:Gene-Environment Interaction D020022:Genetic Predisposition to Disease D005838:Genotype D006801:Humans D008800:Mexico D011084:Polycyclic Aromatic Hydrocarbons D011110:Polymorphism, Genetic D011721:Pyrenes D012307:Risk Factors
Asymmetric dimethylarginine Polycyclic aromatic hydrocarbons Gene-environment interaction Cardiovascular diseases 1-Hydroxypyrene PON1 polymorphism