Odontogenic carcinosarcoma: A systematic review.
The aim of this study was to integrate the available data published on odontogenic carcinosarcoma into a comprehensive analysis of their features, treatment and recurrence. An electronic search with no publication date or language restriction was undertaken in March 2018 in the following databases: Medline Ovid, PubMed, Web of Science, Scopus and LILACS. Eligibility criteria included publications having enough clinical, imaginological and histopathological information to confirm a definite diagnosis of the neoplasm. Data were evaluated descriptively and statistically using the MedCalc software. The Kaplan-Meier method was used for survival analysis. The systematic review detected nine articles from eight countries. Six cases with no age predilection occurred in male individuals complaining of painful swelling in the posterior mandible. Radiographically, the lesions were large, with expansive radiolucency and with ill-defined borders and seven cases were associated with preexisting odontogenic lesions. Radical surgery was the treatment of choice in the majority of cases. Recurrences (n = 6), metastasis (n = 4) and death (n = 4) were frequently observed in many cases. Odontogenic carcinosarcoma is a very aggressive neoplasm with a poor prognosis. This study provides knowledge that could help surgeons, oncologists, otorhinolaryngologists and oral maxillofacial pathologists with the diagnosis and management of these lesions.
['Schuch|Lauren Frenzel|LF|', 'de Arruda|José Alcides Almeida|JAA|', 'Silva|Leni Verônica Oliveira|LVO|', 'Abreu|Lucas Guimarães|LG|', 'Silva|Tarcília Aparecida|TA|', 'Mesquita|Ricardo Alves|RA|']
D000328:Adult D017677:Age Distribution D000368:Aged D002296:Carcinosarcoma D002648:Child D005260:Female D006801:Humans D053208:Kaplan-Meier Estimate D008297:Male D008339:Mandibular Neoplasms D008875:Middle Aged D009362:Neoplasm Metastasis D009364:Neoplasm Recurrence, Local D009808:Odontogenic Tumors D017678:Sex Distribution D055815:Young Adult
Carcinosarcoma Neoplasms Clinical features Head and neck cancer Odontogenic tumors Oral cancer Oral oncology Recurrence rate