Emergence of a Pseudorabies virus variant with increased virulence to piglets.
Pseudorabies virus (PRV) causes Pseudorabies (PR), an economically important disease in domestic swine. PR outbreaks on pig farms caused by PRV variant strains in Bartha-K61-vaccinated pigs have resulted in considerable economic losses in China since 2011. In this study, the pathogenicity of the PRV variant JS-2012 strain to pigs was investigated by experimentally inoculating piglets of different ages in comparison with a classic virulent PRV SC strain. The JS-2012 strain caused an earlier onset of clinical signs and higher mortality in 15, 30, and 60-day-old pigs, as compared with a classic virulent PRV SC strain. The Bartha-K61 vaccination provided complete protection against challenge with classical virulent PRV, but only partial protection against challenge with the JS-2012 strain in piglets. In conclusion, the increased virulence of the PRV variant may have partly contributed to the PR outbreak in China.
['Tong|Wu|W|', 'Liu|Fei|F|', 'Zheng|Hao|H|', 'Liang|Chao|C|', 'Zhou|Yan-jun|YJ|', 'Jiang|Yi-feng|YF|', 'Shan|Tong-ling|TL|', 'Gao|Fei|F|', 'Li|Guo-xin|GX|', 'Tong|Guang-zhi|GZ|']
D000367:Age Factors D000818:Animals D000829:Animals, Domestic D000831:Animals, Newborn D002681:China D002522:Chlorocebus aethiops D004196:Disease Outbreaks D004306:Dose-Response Relationship, Immunologic D011558:Herpesvirus 1, Suid D011557:Pseudorabies D022421:Pseudorabies Vaccines D013552:Swine D013553:Swine Diseases D014611:Vaccination D014709:Vero Cells D014774:Virulence
Pseudorabies virus Variant Pathogenicity