Prognostic Roles of SCC Antigen, CRP and CYFRA 21-1 in Oral Cavity Squamous Cell Carcinoma.
BACKGROUND/AIM
Tumor-related and inflammation-related markers were reported to be prognostic in cancer patients. In this study, we evaluated squamous cell carcinoma antigen (SCC-Ag), cytokeratin 19 fragment (CYFRA 21-1) and C-reactive protein (CRP) simultaneously in oral cavity squamous cell carcinoma (OSCC) patients.


PATIENTS AND METHODS
Two hundred and forty-six newly diagnosed OSCC patients were retrospectively recruited between December 2010 and December 2016.


RESULTS
The elevation of CRP levels (≥5.0 mg/l) and SCC-Ag levels (≥2.0 ng/ml) were significantly related with tumor invasion parameters and metastatic factors. In contrast, the elevation of CYFRA 21-1 levels (≥3.3 ng/ml) was related with extranodal extension alone. For patients with all three markers being elevated before surgery, their overall survival and disease-free survival were significantly worse than others.


CONCLUSION
Concurrent elevation of preoperative SCC-Ag, CYFRA 21-1 and CRP serum levels can be correlated with worse survival rates in OSCC.
['DE Paz|Dante|D|', 'Young|Chi-Kuang|CK|', 'Chien|Huei-Tzu|HT|', 'Tsao|Chung-Kang|CK|', 'Fok|Cheong Chon|CC|', 'Fan|Kang-Hsing|KH|', 'Liao|Chun-Ta|CT|', 'Wang|Hung-Ming|HM|', 'Kang|Chung-Jan|CJ|', 'Chang|Joseph Tung-Chieh|JT|', 'Huang|Shiang-Fu|SF|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D000951:Antigens, Neoplasm D002097:C-Reactive Protein D002294:Carcinoma, Squamous Cell D005260:Female D006801:Humans D053539:Keratin-19 D008297:Male D008875:Middle Aged D009062:Mouth Neoplasms D011379:Prognosis D015843:Serpins
SCC antigen CYFRA 21-1 Oral cavity squamous cell carcinoma C-reactive protein prognosis