Alkalemia and Hepatic Encephalopathy in a Chronic Dialysis Patient.
Hepatic encephalopathy (HE) includes cognitive, psychiatric and neuromotor abnormalities observed from brain dysfunction secondary to liver disease and/or porto-systemic shunting. HE can have a wide range of clinical manifestations ranging from trivial lack of awareness, decreased attention span, personality changes to confusion, seizures, coma, and death. The onset of HE in cirrhosis is a poor prognostic factor. While HE has a complex pathogenesis which is not completely understood, hyperammonemia plays an important role in neurotoxicity and brain dysfunction. Alkalemia facilitates the conversion of NH4+ to NH3, which is free to cross the blood-brain barrier exacerbating HE. Prompt recognition and correction of underlying risk factors is central to the management of HE.
['Duriseti|Parikshit|P|', 'Mamtani|Rishi|R|', 'Madias|Nicolaos E|NE|', 'Strom|James A|JA|']
D000136:Acid-Base Equilibrium D000368:Aged D000641:Ammonia D006501:Hepatic Encephalopathy D006801:Humans D007676:Kidney Failure, Chronic D008103:Liver Cirrhosis D008297:Male D006435:Renal Dialysis
Alkalemia Hepatic encephalopathy Dialysis