Targeting Adult Neurogenesis to Optimize Hippocampal Circuits in Aging.
Millions of individuals suffer from age-related cognitive decline, defined by impaired memory precision. Increased understanding of hippocampal circuit mechanisms underlying memory formation suggests a role for computational processes such as pattern separation and pattern completion in memory precision. We describe evidence implicating the dentate gyrus-CA3 circuit in pattern separation and completion, and examine alterations in dentate gyrus-CA3 circuit structure and function with aging. We discuss the role of adult hippocampal neurogenesis in memory precision in adulthood and aging, as well as the circuit mechanisms underlying the integration and encoding functions of adult-born dentate granule cells. We posit that understanding these circuit mechanisms will permit generation of circuit-based endophenotypes that will edify new therapeutic strategies to optimize hippocampal encoding during aging.
['McAvoy|Kathleen M|KM|', 'Sahay|Amar|A|']
D000375:Aging D000818:Animals D018891:Dentate Gyrus D006624:Hippocampus D006801:Humans D008568:Memory D009434:Neural Pathways D055495:Neurogenesis
Neurogenesis Aging Memory Pattern separation Dentate gyrus Hippocampus