Tricuspid annular plane systolic excursion (TAPSE) in pediatric pulmonary hypertension: Integrating right ventricular ejection efficiency (RVEe) into advanced multi-parametric imaging.
The tricuspid annular plane systolic excursion (TAPSE) has evolved into one of the major echocardiographic indicators of systolic right ventricular (RV) longitudinal function in pediatric pulmonary hypertension (PH). Current RV function research in children with PH focusses on multi-parametric approaches that include TAPSE. The RV ejection efficiency (RVEe) is one of the new variables that reflects the relationship of TAPSE divided by the indexed pulmonary vascular resistance (PVRi) measured by cardiac catheterization. Here, we investigated not only RVEe, but also the ratio of TAPSE divided by pulmonary systolic arterial pressure (PASP; TAPSE/PASP ratio), and a possible association of these indices with NYHA functional class (FC) or the modified ROSS score in 42 children with PH. Both, the RVEe (TAPSE/PVRi) and the TAPSE/PASP ratio were inversely related to NYHA FC and the modified ROSS score in the pediatric PH compared. Compared to TAPSE as single measure, in both multiparametric variables (RVEe, TAPSE/PASP) more pronounced differences in subjects with different NYHA FC/modified ROSS score values were observed. Taken together, the RVEe (TAPSE/PVRi) and TAPSE/PASP ratio distinguish between NYHA FC/modified ROSS score compared to the single echocardiographic variable TAPSE, highlighting the usefulness of a multiparametric approach.
['Koestenberger|Martin|M|', 'Avian|Alexander|A|', 'Cantinotti|Massimiliano|M|', 'Hansmann|Georg|G|', '|||']
D000293:Adolescent D006328:Cardiac Catheterization D002648:Child D002675:Child, Preschool D004452:Echocardiography D015150:Echocardiography, Doppler D005260:Female D005500:Follow-Up Studies D006801:Humans D006976:Hypertension, Pulmonary D007223:Infant D008297:Male D011669:Pulmonary Wedge Pressure D015203:Reproducibility of Results D013318:Stroke Volume D013599:Systole D014261:Tricuspid Valve D014655:Vascular Resistance D016278:Ventricular Function, Right
Pulmonary hypertension Right ventricular ejection efficiency Children Indexed pulmonary vascular resistance Tricuspid annular plane systolic excursion, pulmonary arterial systolic pressure