Health and Prevention Enhancement (H-PEACE): a retrospective, population-based cohort study conducted at the Seoul National University Hospital Gangnam Center, Korea.
PURPOSE
The Health and Prevention Enhancement (H-PEACE) study was designed to investigate the association of diagnostic imaging results, biomarkers and the predisease stage of non-communicable diseases (NCDs), such as malignancies and metabolic diseases, in an average-risk population in Korea.


PARTICIPANTS
This study enrolled a large-scale retrospective cohort at the Healthcare System Gangnam Center, Seoul National University Hospital, from October 2003 to December 2014.


FINDINGS TO DATE
The baseline and follow-up information collected in the predisease stage of NCDs allows for evaluation of an individual's potential NCD risk, which is necessary for establishing personalised prevention strategies. A total of 91 336 health examinees were included in the cohort, and we repeatedly measured and collected information for 50.9% (n=46 484) of the cohort members. All participants completed structured questionnaires (lifestyle, medical history, mini-dietary assessment index, sex-specific variables and psychiatric assessment), doctors' physical examinations, laboratory blood and urine tests and digital chest X-ray imaging. For participants with available data, we also obtained information on specific diagnostic variables using advanced diagnostic tests, including coronary CT for coronary calcium scores, colonoscopy and brain MRI. Furthermore, 17 455 of the participants who provided informed consent and donated blood samples were enrolled into the Gene-environmental interaction and phenotype study, a subcohort of the H-PEACE, from October 2013, and we analysed genome-wide single-nucleotide polymorphism array data for 6579 of these blood samples.


FUTURE PLANS
The data obtained from this cohort will be used to facilitate advanced and accurate diagnostic techniques related to NCDs while considering various phenotypes. Potential collaborators can access the dataset after receiving approval from our institutional review board. Applications can be submitted on the study homepage (http://en-healthcare.snuh.org/HPEACEstudy).
['Lee|Changhyun|C|', 'Choe|Eun Kyung|EK|', 'Choi|Ji Min|JM|', 'Hwang|Yunji|Y|', 'Lee|Young|Y|', 'Park|Boram|B|', 'Chung|Su Jin|SJ|', 'Kwak|Min-Sun|MS|', 'Lee|Jong-Eun|JE|', 'Kim|Joo Sung|JS|', 'Park|Sue Kyung|SK|', 'Cho|Sang-Heon|SH|']
D000328:Adult D000368:Aged D004032:Diet D005260:Female D020022:Genetic Predisposition to Disease D055106:Genome-Wide Association Study D006785:Hospitals, University D006801:Humans D008019:Life Style D008297:Male D008487:Medical History Taking D008875:Middle Aged D056910:Republic of Korea D012189:Retrospective Studies D066106:Seoul
cohort non-communicable disease epidemiology preventive medicine