Stress Granules and ALS: A Case of Causation or Correlation?
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. These aggregates are linked to ALS pathogenesis. Recent evidence has suggested that stress granules may aid the formation of ALS protein aggregates. Here, we summarize current understanding of stress granules, focusing on assembly and clearance. We also assess the evidence linking alterations in stress granule formation and dynamics to ALS protein aggregates and disease pathology.
['Fernandes|Nikita|N|', 'Eshleman|Nichole|N|', 'Buchan|J Ross|JR|']
D000690:Amyotrophic Lateral Sclerosis D001343:Autophagy D003594:Cytoplasmic Granules D006801:Humans D009046:Motor Neurons D034702:RNA-Binding Protein FUS
Stress granules ALS Autophagy C9ORF72 Chaperones Cytoskeleton FUS SOD1 TDP-43 mRNA