[(18) F]CuCF3 : a [(18) F]trifluoromethylating agent for arylboronic acids and aryl iodides.
Positron emission tomography has emerged as the leading method for medical imaging with fluorine-18 as the most widely used radioactive isotope. Here we report a semi-automated method for the preparation of valuable [(18) F]trifluoromethylcopper, as well as its use for the radiosynthesis of [(18) F]trifluoromethylarenes and heteroarenes. Mild conditions of [(18) F]trifluoromethylation make this method particularly useful for the radiosynthesis of pharmacologically relevant [(18) F]trifluoromethylarenes and heteroarenes.
['Ivashkin|Pavel|P|', 'Lemonnier|Gérald|G|', 'Cousin|Jonathan|J|', 'Grégoire|Vincent|V|', 'Labar|Daniel|D|', 'Jubault|Philippe|P|', 'Pannecoucke|Xavier|X|']
D000477:Alkylating Agents D001897:Boronic Acids D005617:Chlorofluorocarbons, Methane D003300:Copper D018360:Crystallography, X-Ray D005462:Fluorine Radioisotopes D006847:Hydrocarbons, Iodinated D007553:Isotope Labeling D008745:Methylation D008958:Models, Molecular D015394:Molecular Structure D009942:Organometallic Compounds D049268:Positron-Emission Tomography D019275:Radiopharmaceuticals
arylboronic acid copper fluorine radiochemistry trifluoromethylation