Promising Antioxidant Activity of Erythrina Genus: An Alternative Treatment for Inflammatory Pain?
The negative impact that oxidative stress has on health is currently known. The complex mechanism of free radicals initiates a series of chain reactions that contribute to the evolution or development of different degenerative disorders. Likewise, these disorders are usually accompanied by inflammatory processes and, therefore, pain. In this sense, reactive oxygen species (ROS) have been shown to promote the nociceptive process, but effective treatment of pain and inflammation still represents a challenge. Over time, it has been learned that there is no single way to relieve pain, and as long as there are no other alternatives, the trend will continue to apply multidisciplinary management, such as promote the traditional use of the Erythrina genus to manage pain and inflammation. In this sense, the Erythrina genus produces a wide range of secondary metabolites, including flavanones, isoflavones, isoflavones, and pterocarpans; these compounds are characterized by their antioxidant activity. Phenolic compounds have demonstrated their ability to suppress pro-oxidants and inhibit inflammatory signaling pathways such as MAPK, AP1, and NFκB. Although there is preclinical evidence supporting its use, the pharmacological effect mechanisms are not entirely clear. Nowadays, there is a fast advancement in knowledge of the disciplines related to drug discovery, but most of nature's medicinal potential has not yet been harnessed. This review analyzes the decisive role that the Erythrina genus could play in managing inflammatory pain mediated by its compounds and its uses as an antioxidant.
['Jiménez-Cabrera|Tania|T|0000-0002-0484-2016', 'Bautista|Mirandeli|M|0000-0002-6725-270X', 'Velázquez-González|Claudia|C|', 'Jaramillo-Morales|Osmar Antonio|OA|0000-0002-5325-3760', 'Guerrero-Solano|José Antonio|JA|0000-0002-9331-9509', 'Urrutia-Hernández|Thania Alejandra|TA|', 'De la O-Arciniega|Minarda|M|0000-0002-5765-1950']
D000818:Animals D000893:Anti-Inflammatory Agents D000975:Antioxidants D000529:Complementary Therapies D004198:Disease Susceptibility D004353:Drug Evaluation, Preclinical D004895:Erythrina D016166:Free Radical Scavengers D006801:Humans D007249:Inflammation D008519:Medicine, Traditional D018384:Oxidative Stress D010146:Pain D059408:Pain Management D010936:Plant Extracts
antioxidant Erythrina inflammatory pain prenylated flavonoids