Effect of the combination of metformin hydrochloride and melatonin on oxidative stress before and during pregnancy, and biochemical and histopathological analysis of the livers of rats after treatment for polycystic ovary syndrome.
The aim of the present study was to analyze the effect of a combination of metformin hydrochloride and melatonin on oxidative stress together with a biochemical and histopathological analysis of the livers of Wistar rats induced with PCOS. The results indicated that a combination of the drugs was more effective in the reduction of plasmatic levels of liver enzyme alanine aminotransferase, nitric oxide and total glutathione, and decreased the inflammatory response and histopathological damage, producing results that were significantly similar to animals from the control group. A mixture of the drugs produced more effective results against liver toxicity caused by PCOS, encouraging the normalization of biochemical parameters. During pregnancy, there was reduced oxidative stress compared to monotherapeutic use of these drugs. Interestingly, the combination of the drugs caused a physiological reaction similar to responses identified in healthy rats without induction of the PCOS control group. However, the clinical and physiological effectiveness of the combination should be further explored, especially with respect to the possible side effects on offspring.
['Lemos|Ana Janaina Jeanine M|AJ|', 'Peixoto|Christina A|CA|', 'Teixeira|Alvaro Aguiar C|AA|', 'Luna|Rayana Leal A|RL|', 'Rocha|Sura Wanessa S|SW|', 'Santos|Hilda Michelly P|HM|', 'Silva|Amanda Karolina S|AK|', 'Nunes|Ana Karolina S|AK|', 'Wanderley-Teixeira|Valéria|V|']
D000818:Animals D000975:Antioxidants D004359:Drug Therapy, Combination D005260:Female D008099:Liver D008550:Melatonin D008687:Metformin D018384:Oxidative Stress D011085:Polycystic Ovary Syndrome D011247:Pregnancy D051381:Rats D017208:Rats, Wistar D016896:Treatment Outcome
Metformin hydrochloride Melatonin Pregnancy Liver Rats Polycystic ovary syndrome