Emerging role of Twist1 in fibrotic diseases.
Epithelial-mesenchymal transition (EMT) is a pathological process that occurs in a variety of diseases, including organ fibrosis. Twist1, a basic helix-loop-helix transcription factor, is involved in EMT and plays significant roles in various fibrotic diseases. Suppression of the EMT process represents a promising approach for the treatment of fibrotic diseases. In this review, we discuss the roles and the underlying molecular mechanisms of Twist1 in fibrotic diseases, including those affecting kidney, lung, skin, oral submucosa and other tissues. We aim at providing new insight into the pathogenesis of various fibrotic diseases and facilitating the development of novel diagnostic and therapeutic methods for their treatment.
['Ning|Xiaoxuan|X|', 'Zhang|Kun|K|', 'Wu|Qingfeng|Q|', 'Liu|Minna|M|', 'Sun|Shiren|S|0000-0001-5322-1454']
D058750:Epithelial-Mesenchymal Transition D005355:Fibrosis D005786:Gene Expression Regulation D006801:Humans D000860:Hypoxia D051795:Hypoxia-Inducible Factor 1, alpha Subunit D007668:Kidney D008168:Lung D009687:Nuclear Proteins D011658:Pulmonary Fibrosis D015398:Signal Transduction D012867:Skin D000071250:Snail Family Transcription Factors D051879:Twist-Related Protein 1
Twist1 fibrotic diseases epithelial-mesenchymal transition