Effects of hypertension on the outcomes of COVID-19: a multicentre retrospective cohort study.
Objectives: Hypertension is thought to be a contributor to mortality in coronavirus disease 2019 patients; however, limited clinical data on the outcomes of COVID-19 in patients with hypertension are available.Methods: This study was designed to confirm whether hypertension affects the outcomes of COVID-19. Results: A total of 983 patients with COVID-19 (female, 48%; male, 52%) were enrolled. Significantly higher odds of 60-day mortality (p = .017) were observed in the hypertensive group. In the hypertensive group, even after adjustment in multivariate analysis, the subgroup of patients 70 years old and older had higher 28-day mortality and total 60-day mortality rates than the other age subgroups (bothp < .05). A total of 297 (89%) COVID-19 patients with hypertension survived, and 35 (11%) died. In addition, compared with hypertensive patients who survived COVID-19, non-survivors had more pre-existing conditions, including cardiovascular diseases and stroke, higher blood pressure on admission, more severe inflammation, and more liver and kidney damage.Conclusion: Hypertension does not affect the outcome of COVID-19, which is different than the conclusions drawn in other studies. However, the 28-day mortality and total 60-day mortality rates of hypertensive patients (age ≥ 70) with COVID-19 were significantly elevated, and compared with the group of survivors, non-surviving COVID-19 patients with hypertension were older, had more basic diseases and had a more severe clinical condition.
['Zhong|Li|L|', 'Wu|Yuting|Y|', 'Gao|Jinghua|J|', 'Zhang|Jinxia|J|', 'Xie|Qifeng|Q|', 'He|Huang|H|', 'Ji|Jingjing|J|', 'Liu|Zheying|Z|', 'Wang|Conglin|C|', 'Liu|Zhifeng|Z|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D000086382:COVID-19 D016022:Case-Control Studies D002681:China D005260:Female D006801:Humans D006973:Hypertension D008297:Male D008875:Middle Aged D011379:Prognosis D012189:Retrospective Studies D012307:Risk Factors D012720:Severity of Illness Index D016019:Survival Analysis
hypertension COVID-19 mortality age clinical characteristics