10-million-years AGO: argonaute on chromatin in yeast and human, a conserved mode of action?
Whereas in yeast the function and mode of action of nuclear RNAi are well documented, mammalian nuclear RNAi is a matter of debates. Several papers support a role for nuclear Argonaute in alternative splicing. However, the molecular mechanism remains elusive. Here, we discuss the human nuclear RNAi mechanism in light of what is known of the yeast process.
['Harel-Bellan|Annick|A|', 'Zazoua|Maya Ameyar|MA|', 'Rachez|Christophe|C|', 'Muchardt|Christian|C|', 'Batsché|Eric|E|']
D017398:Alternative Splicing D060565:Argonaute Proteins D005075:Biological Evolution D002843:Chromatin D012321:DNA-Directed RNA Polymerases D006801:Humans D018960:Hyaluronan Receptors D034622:RNA Interference D062085:RNA, Long Noncoding D034741:RNA, Small Interfering D012441:Saccharomyces cerevisiae
AGO nuclear RNAi splicing AS lincRNA mammals