G-395A polymorphism in the promoter region of the KLOTHO gene associates with reduced cognitive impairment among the oldest old.
This study aimed to examine the possible association between G-395A polymorphism in the promoter region of the KLOTHO gene and cognitive impairment among Chinese nonagenarians and centenarians. This study is a secondary analysis of the Project of Longevity and Aging in Dujiangyan (PLAD) study. Community-dwelling Chinese people aged 90 years or older were included. G-395A (rs1207568) genotyping in the promoter region of the KLOTHO gene was performed using the TaqMan allelic discrimination assay. Cognitive function was assessed with the mini-mental status examination (MMSE). A total of 706 participants (68.0 % female; mean age 93.5 ± 3.6 years) were included. The KLOTHO G-395A polymorphism genotype frequencies for the whole sample were 2.0 % AA, 30.3 % GA, and 67.7 % GG. The GG genotype frequencies for the cognitive impairment and control groups were 70.2 and 62.7 %, respectively. Cognitive impairment prevalence was significantly lower in the GA+AA group than in the GG genotype group (61.4 vs. 69.0 %, p = 0.044). GA+AA genotype subjects had a significantly lower risk of cognitive impairment (odds ratio 0.66; 95 % confidence interval 0.44 to 0.98) than GG genotype individuals after adjusting for age, gender, and other relevant risk factors. KLOTHO G-395A polymorphism associates with reduced cognitive impairment in a sample of Chinese nonagenarians and centenarians.
['Hao|Qiukui|Q|', 'Ding|Xiang|X|', 'Gao|Langli|L|', 'Yang|Ming|M|', 'Dong|Birong|B|']
D000369:Aged, 80 and over D000375:Aging D002681:China D003071:Cognition D003072:Cognition Disorders D004247:DNA D005260:Female D005838:Genotype D005966:Glucuronidase D006801:Humans D000090265:Klotho Proteins D008136:Longevity D008297:Male D011110:Polymorphism, Genetic D015995:Prevalence D011401:Promoter Regions, Genetic D012307:Risk Factors
KLOTHO gene Cognitive impairment Single nucleotide polymorphism