Agenesis of the dorsal pancreas presenting with diabetic ketoacidosis - a case report and literature review.
BACKGROUND
Agenesis of the dorsal pancreas (ADP) is clinically rare, and it is usually accompanied by abdominal pain. Various disorders of glucose metabolism associating with ADP have been reported, but there are only two studies reporting a correlation between ADP and DKA in English literature.


CASE PRESENTATION
We present a case of a patient with ADP accompanied by abdominal pain and diabetic ketoacidosis as the initial clinical presentation. A 30-year-old man presented with a 3-month history of recurrent onset of persistent mild epigastric pain, which worsen when eating. Laboratory tests revealed metabolic acidosis, hyperglycemia, and ketonuria. Phase contrast CT and MRCP showed the absence of the body and tail of the pancreas, as well as the dorsal pancreatic duct. The C-peptide release test indicated β-cell dysfunction. A combination therapy of insulin, pancreatic enzyme supplements, and mosapride citrate were administrated and the pain gradually resolved.


CONCLUSIONS
As glucose metabolism disorders can vary across different individuals, we advise clinicians to consider the diagnosis of ADP for a patient who presents with a glucose metabolism disorder accompanied by abdominal pain, pancreatitis or steatorrhea.
['Yang|Tian|T|http://orcid.org/0000-0002-8085-1838', 'Yang|Xudan|X|', 'Wang|Luping|L|', 'Mo|Jun|J|']
D000328:Adult D000013:Congenital Abnormalities D016883:Diabetic Ketoacidosis D006801:Humans D008297:Male D010179:Pancreas D011379:Prognosis
Agenesis of the dorsal pancreas Diabetic ketoacidosis C-peptide release test Diabetes mellitus