Prognostic evaluation of mucin-5AC expression in intrahepatic cholangiocarcinoma, mass-forming type, following hepatectomy.
AIM
This study aimed to investigate the clinicopathological predictors of survival in patients with intrahepatic cholangiocarcinoma, mass-forming type (ICC-MF), following curative intent hepatectomy.


METHODS
Clinical characteristics and outcomes were analyzed in a series of 42 patients who underwent curative hepatectomy for ICC-MF between February 1987 and December 2012. The relationship between immunohistochemical expression profiles of mucin (MUC) core proteins (MUC2, MUC5AC, and MUC6) and surgical outcomes was examined.


RESULTS
The overall median follow-up period was 2.6 years (0.2-17.9). Bile duct reconstruction (p = 0.017), lymph node metastasis (p = 0.049), maximal mass diameter ≥5.0 cm (p = 0.002), and MUC5AC expression (p = 0.003) were identified as significant adverse predictors of overall survival by univariate analysis. Bile duct reconstruction (p = 0.048), maximal mass diameter ≥5.0 cm (p = 0.002), and MUC5AC expression (p = 0.005) were found to be independent predictors of poor prognosis by multivariate analysis. Maximal mass diameter ≥5.0 cm (p = 0.011) was found to be an independent predictor for the tumor recurrence. There was a strong correlation between MUC5AC expression and lymph node metastasis (p = 0.021). MUC6 expression was more frequent in patients with concurrent MUC5AC expression (p = 0.019).


CONCLUSIONS
MUC5AC expression was significantly related to long-term prognosis and aggressive tumor development, and may be a useful prognostic marker.
['Abe|T|T|', 'Amano|H|H|', 'Shimamoto|F|F|', 'Hattori|M|M|', 'Kuroda|S|S|', 'Kobayashi|T|T|', 'Tashiro|H|H|', 'Ohdan|H|H|']
D000368:Aged D000369:Aged, 80 and over D001650:Bile Duct Neoplasms D001653:Bile Ducts, Intrahepatic D014408:Biomarkers, Tumor D018281:Cholangiocarcinoma D005260:Female D005500:Follow-Up Studies D006498:Hepatectomy D006801:Humans D007150:Immunohistochemistry D008297:Male D008875:Middle Aged D055271:Mucin 5AC D009367:Neoplasm Staging D011184:Postoperative Period D011379:Prognosis D012189:Retrospective Studies D013997:Time Factors D014057:Tomography, X-Ray Computed
Intrahepatic cholangiocarcinoma Mass-forming type Mucin core protein