NF-κB and tPA Signaling in Kidney and Other Diseases.
The activation of the nuclear factor-κB (NF-κB) pathway plays a central role in the initiation and progression of inflammation, which contributes to the pathogenesis and progression of various human diseases including kidney, brain, and other diseases. Tissue plasminogen activator (tPA), a serine protease regulating homeostasis of blood coagulation, fibrinolysis, and matrix degradation, has been shown to act as a cytokine to trigger profound receptor-mediated intracellular events, modulate the NF-κB pathway, and mediate organ dysfunction and injury. In this review, we focus on the current understanding of NF-κB and tPA signaling in the development and progression of kidney disease. Their roles in the nervous and cardiovascular system are also briefly discussed.
['White|Samantha|S|0000-0001-9619-4847', 'Lin|Ling|L|0000-0001-5527-0575', 'Hu|Kebin|K|0000-0002-0829-4256']
D000818:Animals D006801:Humans D007249:Inflammation D007674:Kidney Diseases D008264:Macrophages D016328:NF-kappa B D015398:Signal Transduction D010959:Tissue Plasminogen Activator
nuclear factor-κB (NF-κB) inflammation tissue plasminogen activator (tPA) kidney disease cardiovascular disease ischemic stroke kidney fibrosis macrophages