Incidence of anti-neutrophil cytoplasmic antibody-associated vasculitis before and after the February 2011 Christchurch Earthquake.
BACKGROUND
It has been suggested that environmental pollution from an earthquake might be associated with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).


AIM
To determine the incidence of AAV during the 3-year period before (period 1), and the 3 years following (period 2), the earthquake that occurred on 22 February 2011 in Christchurch, New Zealand.


METHODS
All ANCA tests performed in the Canterbury region for 3 years before the earthquake (period 1, 2007-2010), and for 3 years after the earthquake (period 2, 2011-2014) were examined. AAV was defined according to The European Medicines Agency classification algorithm. Medical records were reviewed and cases were included if they were newly diagnosed within the study period. Incidence was calculated using population data from the 2013 New Zealand census.


RESULTS
A total of 52 new cases of AAV was identified. The incidence in period 1 was 1.87/100 000/annum (95% C.I. 1.23-2.72), and for period 2 was 1.73/100 000/annum (95% C.I. 1.12-2.55). There was no statistically significant difference in incidence between the two study periods. There was no difference when analysing by myeloperoxidase (MPO) or proteinase-3 status, or restricting the analyses to those residing in an urban environment. The mean age at diagnosis for MPO AAV was significantly younger in period 2 than period 1 (61 years vs 71 years, P = 0.05). There were no other clinically important differences between the two groups.


CONCLUSION
This study does not support the hypothesis that an environmental agent, caused by dust pollution related to earthquake damage, has a causative role in the pathogenesis of AAV.
['Farquhar|H J|HJ|', 'McGettigan|B|B|', 'Chapman|P T|PT|', "O'Donnell|J L|JL|", 'Frampton|C|C|', 'Stamp|L K|LK|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis D019268:Antibodies, Antineutrophil Cytoplasmic D004190:Disasters D055866:Earthquakes D005260:Female D006801:Humans D015994:Incidence D007223:Infant D008297:Male D008875:Middle Aged D009520:New Zealand
incidence vasculitis earthquakes anti-neutrophil cytoplasmic antibodies