Ovarian growth impairment after chronic exposure to Roundup Ultramax® in the estuarine crab Neohelice granulata.
Adult females of the estuarine crab Neohelice granulata were exposed to the glyphosate formulation Roundup Ultramax® during the entire 3-month pre-reproductive period. At the end of the assay, a significant higher increment of glycemia was noted at both glyphosate concentrations assayed (0.01 and 0.2 mg/L, acid equivalent). Although no differences were observed in the gonadosomatic index, a significantly higher proportion of reabsorbed vitellogenic oocyte was observed at the highest glyphosate concentration, together with a significant decrease of vitellogenin content in the ovary. In addition, some in vitro assays were carried out by co-incubating small pieces of ovary with or without the addition of Roundup; at both concentrations tested (same as those used in vivo), a decrease in the ovarian vitellogenin content was observed, whereas the ovarian protein synthesis was significantly inhibited by glyphosate at 0.2 mg/L in the Roundup formulation used.
['Canosa|Ivana S|IS|', 'Silveyra|Gabriela R|GR|', 'Avigliano|Luciana|L|', 'Medesani|Daniel A|DA|', 'Rodríguez|Enrique M|EM|http://orcid.org/0000-0002-3804-8902']
D000818:Animals D003386:Brachyura D004781:Environmental Exposure D005260:Female D005998:Glycine D006540:Herbicides D010053:Ovary D012098:Reproduction D017747:Seafood D014819:Vitellogenins
Roundup Crabs Glyphosate Vitellogenin Ovary Reproduction