Prediction of Alzheimer's disease diagnosis within 14 years through Aβ misfolding in blood plasma compared to APOE4 status, and other risk factors.
INTRODUCTION
Alzheimer's disease (AD) has a long prodromal stage and identifying high-risk individuals is critical. We aimed to investigate the ability of Aβ misfolding in blood plasma, APOE4 status, and dementia risk factors to predict diagnosis of AD.


METHODS
Within a community-based cohort, Aβ misfolding in plasma measured by immuno-infrared sensor and APOE genotype were determined at baseline in 770 participants followed over 14 years. Associations between Aβ misfolding, APOE4, and other predictors with clinical AD, vascular dementia, and mixed dementia diagnoses were assessed.


RESULTS
Aβ misfolding was associated with a 23-fold increased odds of clinical AD diagnosis within 14 years. No association was observed with vascular dementia/mixed dementia diagnoses. APOE4-positive participants had a 2.4-fold increased odds of clinical AD diagnosis within 14 years.


DISCUSSION
Aβ misfolding in blood plasma was a strong, specific risk prediction marker for clinical AD even many years before diagnosis in a community-based setting.
['Stocker|Hannah|H|', 'Nabers|Andreas|A|', 'Perna|Laura|L|', 'Möllers|Tobias|T|', 'Rujescu|Dan|D|', 'Hartmann|Annette|A|', 'Holleczek|Bernd|B|', 'Schöttker|Ben|B|', 'Gerwert|Klaus|K|', 'Brenner|Hermann|H|']
D000368:Aged D000544:Alzheimer Disease D016229:Amyloid beta-Peptides D053327:Apolipoprotein E4 D015415:Biomarkers D016022:Case-Control Studies D015140:Dementia, Vascular D005260:Female D005838:Genotype D006801:Humans D008297:Male D012307:Risk Factors D013997:Time Factors
Alzheimer's disease Blood plasma Vascular dementia Amyloid beta (Aβ) Apolipoprotein E (APOE) Risk stratification