Is treatment de-escalation a reality in HPV related oropharyngeal cancer?
The incidence of HPV related oropharyngeal squamous cell carcinoma (OPSCC) is rapidly increasing. It is now well recognised as a distinct clinical and biologic entity, compared to traditional OPSCC. The majority of these patients have an excellent prognosis due to the chemo-radiosensitive nature of these tumours. The de-escalation of current treatment regimens have therefore been proposed in an attempt to reduce the long term treatment related morbidity of this much younger patient cohort. Several of the more pertinent points regarding safe de-escalation strategies are considered within this manuscript.
['Oosthuizen|J C|JC|', 'Kinsella|J B|JB|']
D002294:Carcinoma, Squamous Cell D059248:Chemoradiotherapy D005260:Female D005544:Forecasting D006801:Humans D015994:Incidence D008297:Male D009361:Neoplasm Invasiveness D009367:Neoplasm Staging D009959:Oropharyngeal Neoplasms D030361:Papillomavirus Infections D018570:Risk Assessment D016896:Treatment Outcome
Treatment De-escalation Oropharyngeal SCC Squamos cell carcinoma