Internal states drive nutrient homeostasis by modulating exploration-exploitation trade-off.
Internal states can profoundly alter the behavior of animals. A quantitative understanding of the behavioral changes upon metabolic challenges is key to a mechanistic dissection of how animals maintain nutritional homeostasis. We used an automated video tracking setup to characterize how amino acid and reproductive states interact to shape exploitation and exploration decisions taken by adult Drosophila melanogaster. We find that these two states have specific effects on the decisions to stop at and leave proteinaceous food patches. Furthermore, the internal nutrient state defines the exploration-exploitation trade-off: nutrient-deprived flies focus on specific patches while satiated flies explore more globally. Finally, we show that olfaction mediates the efficient recognition of yeast as an appropriate protein source in mated females and that octopamine is specifically required to mediate homeostatic postmating responses without affecting internal nutrient sensing. Internal states therefore modulate specific aspects of exploitation and exploration to change nutrient selection.
['Corrales-Carvajal|Verónica María|VM|0000-0002-3813-5790', 'Faisal|Aldo A|AA|', 'Ribeiro|Carlos|C|0000-0002-9542-7335']
D000818:Animals D004331:Drosophila melanogaster D005247:Feeding Behavior D005518:Food Preferences D006706:Homeostasis D009747:Nutritional Physiological Phenomena D012726:Sexual Behavior, Animal D012903:Smell D014741:Video Recording
internal states homeostasis behavior nutrition D. melanogaster feeding neurogenetics neuroscience