Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives.
Artemisinin and its derivatives have been reported to be experimentally effective for the treatment of highly aggressive cancers without developing drug resistance, they are useful for the treatment of malaria, other protozoal infections and they exhibit antiviral activity. However, they are limited pharmacologically by their poor bioavailability, short half-life in vivo, poor water solubility and long term usage results in toxicity. They are also expensive for the treatment of malaria when compared to other antimalarials. In order to enhance their therapeutic efficacy, they are incorporated onto different drug delivery systems, thus yielding improved biological outcomes. This review article is focused on the currently synthesized derivatives of artemisinin and different delivery systems used for the incorporation of artemisinin and its derivatives.
['Aderibigbe|Blessing Atim|BA|']
D000818:Animals D000962:Antimalarials D037621:Artemisinins D004333:Drug Administration Routes D004337:Drug Carriers D004339:Drug Compounding D016503:Drug Delivery Systems D015195:Drug Design D006801:Humans D015394:Molecular Structure
drug delivery systems artemisinin arteether artemether artesunate