Shift of the interconnection from the reaction system of paraoxonase 1 to the peroxidation reaction system of myeloperoxidase with HDL-C levels: a marker of atherosclerosis in patients with normal cholesterol levels.
BACKGROUND
The interconnectivity of the peroxidation reaction system of myeloperoxidase (PRSM) or the reaction system of paraoxonase 1 (RSP1) with atherosclerosis remains elusive in patients with normal cholesterol levels.


METHODS
A total of 55 atherosclerotic patients with normal cholesterol concentrations and 45 control subjects were analyzed. Pearson's correlation was used to investigate the correlation between the levels of oxidative stress-related indices (HNE-LDL, MDA-LDL and protein carbonyls) and cholesterol indices (TC, HDL-C and LDL-C) and individual factor in RSP1 and PRSM (paraoxonase 1 activity, ionized calcium, myeloperoxidase peroxidation activity, or H2O2). Response surface regression (RSR) was used to analyze the interconnection of PRSM and RSP1 with the levels of oxidative stress-related indices and cholesterol indices.


RESULTS
The relation between PRSM and the increase of HNE-LDL and MDA-LDL was attributable to myeloperoxidase peroxidation activity, H2O2 concentrations and the interaction between myeloperoxidase peroxidation activity and H2O2 in the patients. PRSM preferred contribution to cholesterol levels in the cases. The interconnection of PRSM with TC was dependent on the association of PRSM with HDL-C and LDL-C.


CONCLUSIONS
The shift of interconnection with HDL-C levels from RSP1 to PRSM represents a marker for atherosclerotic patients with normal cholesterol levels.
['Wang|Fan|F|', 'Liu|Yawen|Y|', 'Cong|Yetong|Y|', 'Li|Pengpeng|P|', 'Li|Yong|Y|', 'Yan|Zhihui|Z|', 'Tang|Yuan|Y|', 'Cheng|Yi|Y|', 'Zheng|Yang|Y|']
D000328:Adult D000447:Aldehydes D043303:Aryldialkylphosphatase D050197:Atherosclerosis D015415:Biomarkers D002118:Calcium D016022:Case-Control Studies D008076:Cholesterol, HDL D008078:Cholesterol, LDL D005260:Female D006801:Humans D006861:Hydrogen Peroxide D008077:Lipoproteins, LDL D008297:Male D008315:Malondialdehyde D008875:Middle Aged D009195:Peroxidase D011379:Prognosis D050050:Protein Carbonylation D014280:Triglycerides
Reaction system Paraoxonase 1 Myeloperoxidase Atherosclerosis Cholesterol levels Oxidative stress