Association of the human aryl hydrocarbon receptor repressor (AhRR)-c.565C>G transversion with male infertility: A case-control study from Iran.
Dioxins (eg, 2,3,7,8-tetrachlorodibenzo-p-dioxin/TCDD), as environmental endocrine disruptors and toxic carcinogens, can affect male reproductive health. The influence of dioxins is mediated via the aryl hydrocarbon receptor (AhR) pathway and its repressor (AhRR). In this study, we investigated the association of AhRR-c.565C>G transversion polymorphism with male infertility. In a hospital-based case-control study, 221 semen samples (111 infertile and 110 healthy controls) based on World Health Organization guidelines were collected from in vitro fertilization centers of Babol, Iran. The AhRR-c.565C>G (rs2292596) polymorphism was genotyped using a polymerase chain reaction-restriction fragment length polymorphism analysis. The difference in the allele frequency of AhRR-c.565C>G transversion polymorphism did not reach a significant level. The genotype frequency was statistically significantly different between fertile and infertile men. We found that polymorphism rs2292596 (Pro185Ala) was statistically significantly associated with the risk of male infertility. In addition, the statistical difference became more significant when the frequency was compared between the Pro/Pro genotype and the Pro/Ala plus Ala/Ala genotype. The 185 Pro wild-type alleles of AhRR may be associated with the risk of male infertility. The proallele also may diminish inhibition of AhR-mediated signaling of exposure to environmental pollutants.
['Mohammad-Hasani|Azadeh|A|', 'Hosseinzadeh Colagar|Abasalt|A|0000-0001-6536-8250', 'Fallah|Ali|A|']
D000328:Adult D051792:Basic Helix-Loop-Helix Transcription Factors D016022:Case-Control Studies D004147:Dioxins D005787:Gene Frequency D056726:Genetic Association Studies D020022:Genetic Predisposition to Disease D006801:Humans D007248:Infertility, Male D007492:Iran D008297:Male D008875:Middle Aged D017354:Point Mutation D020641:Polymorphism, Single Nucleotide D018336:Receptors, Aryl Hydrocarbon
male infertility dioxin toxic carcinogen reproductive health AhRR c.565C>G