Lack of T-cell-mediated IL-2 and TNFα production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection.
For an effective T-cell activation and response, co-stimulation is required in addition to the antigen-specific signal from their antigen receptors. The CD2/CD58 interaction is considered as one of the most important T-cell co-stimulatory pathways for T-cell activation and proliferation, and its role in regulating intestinal T-cell function in acute and chronic SIV -infected macaques is poorly documented. Here, we demonstrated a significant reduction of CD58 expression in both T- and B-cell populations during acute SIV infection along with high plasma viral load and a loss of intestinal CD4+ T cells compared to SIV-uninfected control macaques. The reduction of CD58 expression in T cells was correlated with the reduced expression of T-cell-mediated IL-2 and TNFα production. Together, these results indicate that reduction in the CD2/CD58 interaction pathway in mucosal lymphocytes might play a crucial role in mucosal T-cell dysfunction during acute SIV/HIV infection.
['Pan|Diganta|D|', 'Das|Arpita|A|', 'Srivastav|Sudesh K|SK|', 'Traina-Dorge|Vicki|V|', 'Didier|Peter J|PJ|', 'Pahar|Bapi|B|']
D000818:Animals D001402:B-Lymphocytes D018968:CD58 Antigens D015870:Gene Expression D007376:Interleukin-2 D007413:Intestinal Mucosa D000075942:Intraepithelial Lymphocytes D008213:Lymphocyte Activation D008251:Macaca D010949:Plasma D016097:Simian Acquired Immunodeficiency Syndrome D015302:Simian Immunodeficiency Virus D014409:Tumor Necrosis Factor-alpha D019562:Viral Load
CD58 CD2 SIV cytokine mucosal immunology