Patient-reported Outcomes During Treatment in Patients with Moderate-to-severe Psoriasis: A Danish Nationwide Study.
The initiation and evaluation of treatment with biologics for psoriasis is based on the Psoriasis Area Severity Index (PASI) and/or Dermatological Life Quality Index (DLQI). However, these indices do not always correlate well, and changes in the DLQI do not always follow changes in the PASI. Based on data from the Danish national registry (DERMBIO), this study investigated the correlation between changes in PASI and DLQI in a cohort of patients with moderate-to-severe psoriasis treated with biologics or apremilast using Spearman's rank correlation analyses. The correlation analysis of 1,677 patients, of whom 276 had available data after 5 years, showed weak-to-moderate correlation between PASI and DLQI during a 5-year period and between changes in PASI and DLQI: 0.58 (p < 0.0001) for baseline to 3 months and 0.42 (p < 0.0001) for 3 to 12 months. The first question on "Symptoms and feelings" made up the largest proportion of the overall DLQI. The correlation between PASI and DLQI is weak-to-moderate and varies over time. Changes in PASI correlate weak-to-moderately with changes in DLQI during the first 12 months of treatment, with symptoms being the most important factor contributing to impaired quality of life.
['Loft|Nikolai Dyrberg|ND|', 'Egeberg|Alexander|A|', 'Rasmussen|Mads Kirchheiner|MK|', 'Bryld|Lars Erik|LE|', 'Gniadecki|Robert|R|', 'Dam|Tomas Norman|TN|', 'Iversen|Lars|L|', 'Skov|Lone|L|']
D000328:Adult D000367:Age Factors D015535:Arthritis, Psoriatic D001688:Biological Products D003718:Denmark D004305:Dose-Response Relationship, Drug D004334:Drug Administration Schedule D006801:Humans D008297:Male D008875:Middle Aged D000071066:Patient Reported Outcome Measures D011565:Psoriasis D011788:Quality of Life D012042:Registries D018570:Risk Assessment D012720:Severity of Illness Index D012737:Sex Factors D018709:Statistics, Nonparametric D013792:Thalidomide D016896:Treatment Outcome
patient-reported outcomes psoriasis biologics Dermatology Life Quality Index Psoriasis Area and Severity Index