Nomogram to predict the risk and survival of synchronous bone metastasis in colorectal cancer: a population-based real-world analysis.
PURPOSE
Bone metastasis (BM) can obviously affect the quality of life of patients in colorectal cancer (CRC), and the whole management of patients with BM would be attractive in current clinical practice.


METHODS
A total of 52,859 patients during 2010-2015 were collected from Surveillance, Epidemiology, and End Results (SEER) database. After propensity score matching (PSM), cancer-specific survival (CCS) and overall survival (OS) with BM were adopted to assess survival probability difference. Logistic regression was used to identify risk factors for BM; COX proportion hazard regression was applied to explore prognosticators for OS in patients with BM. Subsequently, nomograms were constructed and receiver operating curves (ROCs) were used to confirm the validation of nomogram.


RESULTS
Three hundred and forty-two (0.65%) patients were diagnosed with synchronous BM. After PSM, 16 variables were balanced. Tumor site, histology, grade, T stage, N stage, CEA, radiochemotherapy, surgery, and liver/lung/brain metastases were associated with BM, and histology, grade, T stage, N stage, CEA, chemotherapy, surgery, and liver/lung metastases were prognosticators for BM survival. Nomograms were applied and the ROC curve proved the predictive effects.


CONCLUSION
CRC patients with BM have worse real-world survival. Nomogram can predict incidence of BM in CRC patients and survival among patients with BM.
['Han|Lingyu|L|', 'Dai|Weixing|W|', 'Mo|Shaobo|S|', 'Xiang|Wenqiang|W|', 'Li|Qingguo|Q|', 'Xu|Ye|Y|', 'Wang|Renjie|R|', 'Cai|Guoxiang|G|http://orcid.org/0000-0003-2953-3460']
D001859:Bone Neoplasms D015179:Colorectal Neoplasms D006801:Humans D009367:Neoplasm Staging D049451:Nomograms D011379:Prognosis D011788:Quality of Life
Nomogram Metastasis Colorectal cancer Cancer risk factors Prognosis