Parent support improves weight loss in adolescents and young adults with Down syndrome.
OBJECTIVE
To assess whether parent training in behavioral intervention, combined with a 16-session nutrition and activity education program, would improve weight loss relative to nutrition and activity education alone in adolescents and young adults with Down syndrome.


STUDY DESIGN
Twenty-one patients with Down syndrome aged 13-26 years with a body mass index ≥ 85 th percentile were enrolled and randomized to a 6-month nutrition and activity education intervention (n = 10) or to a nutrition and activity education+behaviorial intervention (n = 11), and followed for 6 months after the active intervention period (1-year follow-up). The primary outcome measure was body weight; secondary outcomes included percentage body fat by bioelectric impedance; intake of fruits, vegetables, and energy-dense low-nutrient snack food (treats) by 3-day food record; and moderate/vigorous physical activity by accelerometry.


RESULTS
At 6 months, mean body weight in the nutrition and activity education+behavioral intervention group was 3.2 kg lower than that in the nutrition and activity education group (95% CI, 1.0-5.5 kg; P = .005). Mean group differences were sustained at 1 year (3.6 kg; 95% CI, 1.4-5.9 kg; P = .002). At 6 months, moderate/vigorous physical activity time increased by an average of 18 minutes/day compared with baseline in the nutrition and activity education+behavioral intervention group (P = .01) and decreased by 7 minutes/day in the nutrition and activity education group (P = .30). These changes were largely maintained at 1 year, but were not statistically significant. Vegetable intake in the nutrition and activity education+behavioral intervention group exceeded that in the nutrition and activity education group by a mean of 1.6 servings at 1 year (P = .009), but not at 6 months. No between-group differences were observed for percentage body fat or consumption of fruits or treats.


CONCLUSION
Parent-supported behavioral intervention appears to be a successful adjunct to a 6-month nutrition education intervention in achieving weight loss in adolescents and young adults with Down syndrome.
['Curtin|Carol|C|', 'Bandini|Linda G|LG|', 'Must|Aviva|A|', 'Gleason|James|J|', 'Lividini|Keith|K|', 'Phillips|Sarah|S|', 'Eliasziw|Misha|M|', 'Maslin|Melissa|M|', 'Fleming|Richard K|RK|']
D000273:Adipose Tissue D000293:Adolescent D000328:Adult D001823:Body Composition D015992:Body Mass Index D001835:Body Weight D004314:Down Syndrome D005247:Feeding Behavior D005260:Female D005638:Fruit D015438:Health Behavior D006266:Health Education D006801:Humans D008297:Male D016487:Parenting D010290:Parents D012944:Social Support D016896:Treatment Outcome D014675:Vegetables D015431:Weight Loss D055815:Young Adult
Percentage body fat %fat