Hyperpatulones C-G, new spirocyclic polycyclic polyprenylated acylphloroglucinols from the leaves of Hypericum patulum.
Five new spirocyclic polycyclic polyprenylated acylphloroglucinols, Hyperpatulones C-G (1-5), were obtained from the leaves of Hypericum patulum. Their structures were characterized by the comprehensive analysis of their IR, NMR, CD spectra and HRESIMS data. All the new compounds were evaluated for the α-glycosidase inhibitory activities. Among them, compounds 3-5 showed α-glucosidase inhibitory activities, with IC50 values of 14.06-37.69 μM.
['Zhang|Yu-Xin|YX|', 'Ao|Zhen|Z|', 'He|Yi-Wen|YW|', 'Lu|Jin-Yu|JY|', 'Chen|Xin-Lin|XL|', 'Kong|Ling-Yi|LY|', 'Luo|Jian-Guang|JG|']
Spirocyclic polycyclic polyprenylated acylphloroglucinols Hypericum patulum α-Glucosidase inhibitory activity