Nano-Fenton Reactors as a New Class of Oxidative Stress Amplifying Anticancer Therapeutic Agents.
Cancer cells, compared to normal cells, are under oxidative stress associated with an elevated level of reactive oxygen species (ROS) and are more vulnerable to oxidative stress induced by ROS generating agents. Thus, manipulation of the ROS level provides a logical approach to kill cancer cells preferentially, without significant toxicity to normal cells, and great efforts have been dedicated to the development of strategies to induce cytotoxic oxidative stress for cancer treatment. Fenton reaction is an important biological reaction in which irons convert hydrogen peroxide (H2O2) to highly toxic hydroxyl radicals that escalate ROS stress. Here, we report Fenton reaction-performing polymer (PolyCAFe) micelles as a new class of ROS-manipulating anticancer therapeutic agents. Amphiphilic PolyCAFe incorporates H2O2-generating benzoyloxycinnamaldehyde and iron-containing compounds in its backbone and self-assembles to form micelles that serve as Nano-Fenton reactors to generate cytotoxic hydroxyl radicals, killing cancer cells preferentially. When intravenously injected, PolyCAFe micelles could accumulate in tumors preferentially to remarkably suppress tumor growth, without toxicity to normal tissues. This study demonstrates the tremendous translatable potential of Nano-Fenton reactors as a new class of anticancer drugs.
['Kwon|Byeongsu|B|', 'Han|Eunji|E|', 'Yang|Wonseok|W|', 'Cho|Wooram|W|', 'Yoo|Wooyoung|W|', 'Hwang|Junyeon|J|', 'Kwon|Byoung-Mog|BM|', 'Lee|Dongwon|D|']
D000818:Animals D000970:Antineoplastic Agents D017209:Apoptosis D045744:Cell Line, Tumor D053938:DNA Fragmentation D005296:Ferrous Compounds D057809:HEK293 Cells D006801:Humans D006861:Hydrogen Peroxide D006863:Hydrogen-Ion Concentration D017665:Hydroxyl Radical D007501:Iron D000075163:Metallocenes D051379:Mice D008819:Mice, Nude D008823:Micelles D041681:NIH 3T3 Cells D009369:Neoplasms D018384:Oxidative Stress D011108:Polymers D017382:Reactive Oxygen Species D014183:Transplantation, Heterologous
oxidative stress cancer Fenton reaction hydroxyl radical polymeric micelles