C21 steroidal glycosides and oligosaccharides from the root bark of Periploca sepium.
Four new C21 steroidal glycosides (1-4), named perisepiumosides FI (1-4) together with six known steroidal glycosides (5-10) and four oligosaccharides (11-14), were isolated from the root bark of Periploca sepium. Their structures were characterized on the basis of 1D and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. The evaluation of inhibition activity against human A-549 and HepG2 cell lines indicated that compounds 2, 8, 10 and 13 showed different levels of cytotoxic activities with IC50 values ranging from 0.61 to 7.86μM.
['Gu|Xin-Yue|XY|', 'Wu|Zhou-Wei|ZW|', 'Wang|Lun|L|', 'Li|Fu|F|', 'Chen|Bin|B|', 'Yu|Kai|K|', 'Wang|Ming-Kui|MK|']
D000072283:A549 Cells D006027:Glycosides D056945:Hep G2 Cells D006801:Humans D015394:Molecular Structure D009844:Oligosaccharides D031109:Periploca D018517:Plant Roots
Oligosaccharides Periploca sepium Cytotoxic activities C(21) steroidal glycosides