Changes in serotype distribution and antibiotic resistance of nasopharyngeal isolates of Streptococcus pneumoniae from children in Korea, after optional use of the 7-valent conjugate vaccine.
We investigated serotype distribution and antimicrobial resistance of pneumococcal carriage isolates from children after optional immunization with the 7-valent pneumococcal conjugate vaccine (PCV7) in Korea. From June 2009 to June 2010, 205 (16.5%) pneumococcal isolates were obtained from 1,243 nasopharyngeal aspirates of infants and children at Seoul National University Children's Hospital, Korea. Serotype was determined by Quellung reaction and antibiotic susceptibility was tested by E-test. The results were compared to previous studies done in the pre-PCV7 period. In this study, the most common serotypes were 6A (15.3%), 19A (14.7%), 19F (10.2%), 35B (7.3%), and 6D (5.6%). The proportion of PCV7 serotypes decreased from 61.9% to 23.8% (P < 0.001). The overall penicillin nonsusceptibility rate increased from 83.5% to 95.4% (P = 0.001). This study demonstrates the impact of optional PCV7 vaccination in Korea; the proportion of all PCV7 serotypes except 19F decreased while antimicrobial resistant serotypes 6A and 19A further increased.
['Cho|Eun Young|EY|', 'Kang|Hyun Mi|HM|', 'Lee|Jina|J|', 'Kang|Jin Han|JH|', 'Choi|Eun Hwa|EH|', 'Lee|Hoan Jong|HJ|']
D000900:Anti-Bacterial Agents D002675:Child, Preschool D024881:Drug Resistance, Bacterial D006801:Humans D007223:Infant D008826:Microbial Sensitivity Tests D009305:Nasopharynx D011008:Pneumococcal Infections D056910:Republic of Korea D012703:Serotyping D013296:Streptococcus pneumoniae D014611:Vaccination D018074:Vaccines, Conjugate
Serotype Streptococcus pneumoniae Drug Resistance Pneumococcal Vaccines