Safety of an inactivated SARS-CoV-2 vaccine among healthcare workers in China.
Background: Although the inactivated SARS-CoV-2 vaccine (CoronaVac) has undergone preclinical tests and clinical trials evaluating its efficacy and safety, few data have been reported in the post-licensure real-world setting. We aimed to assess the safety of the vaccine among healthcare workers.Methods: A self-administered online survey on monitoring adverse reactions post vaccination was conducted among the staff who worked at and were vaccinated in a tertiary hospital in Taizhou, China, from February 24 to 7 March 2021. A total of 1526 subjects responded to the questionnaire when they received an e-mail or an e-poster on WeChat.Results: The incidences of overall adverse reactions after the first and second injections were 15.6% (238/1526) and 14.6% (204/1397), respectively. The most common adverse reaction was localized pain at the injection site, with an incidence of 9.6% and 10.7% after each dose, accounting for 61.8% and 73.0% of adverse reactions, respectively. Fatigue, muscle pain, and headache were the most common systemic adverse reactions.Conclusions: These findings implied that the inactivated CoronaVac vaccine has an acceptable safety profile among healthcare workers due to the low incidence of self-reported adverse reactions. This may boost public confidence in nationwide mass vaccination campaigns.
['Zhang|Mei-Xian|MX|0000-0002-6538-7037', 'Zhang|Tong-Tong|TT|', 'Shi|Gui-Feng|GF|', 'Cheng|Feng-Min|FM|', 'Zheng|Yan-Ming|YM|', 'Tung|Tao-Hsin|TH|', 'Chen|Hai-Xiao|HX|']
D000293:Adolescent D000328:Adult D000086382:COVID-19 D000086663:COVID-19 Vaccines D002681:China D003430:Cross-Sectional Studies D005260:Female D006282:Health Personnel D006801:Humans D008297:Male D008875:Middle Aged D057566:Self Report D015164:Vaccines, Inactivated D055815:Young Adult
safety healthcare workers China Adverse reaction COVID-19 vaccination