The Influence of Race and Sex on the Side Effect Profile of Methotrexate in the Treatment of Uveitis.
Purpose: To detect any correlation between race and sex and the side effects of methotrexate in uveitis treatment. Methods: Retrospective review of patients seen at Northwestern Memorial Hospital between August 2012 and September 2014 with a history of MTX treatment for uveitis. Demographic, treatment, and side-effect data were collected for each patient. Results: Ninety-seven patients were included (25 males, 72 females). Twenty-eight patients reported African American race, 60 reported Caucasian race, and the remaining 9 reported Asian, Hispanic, or Arabic ethnicity. Males experienced more gastrointestinal upset than females (24% versus 13.8%). Caucasians had more gastrointestinal complaints (20% versus 8%) while African Americans developed more hair loss (14% versus 6.6%), although the numbers were too small to detect a statistical difference. Conclusion: While our sample was small, these findings suggest racial and gender disparities in the side effects experienced by patients treated with methotrexate. This information may be useful to clinicians counseling patients on risk profile.
['LaMattina|Kara C|KC|', 'Escott|Sarah M|SM|', 'Malalis|Julia F|JF|', 'Mai|David|D|', 'Harada|Yosuke|Y|', 'Goldstein|Debra A|DA|']
D000293:Adolescent D000328:Adult D002648:Child D006801:Humans D007166:Immunosuppressive Agents D015994:Incidence D008727:Methotrexate D008875:Middle Aged D044469:Racial Groups D012189:Retrospective Studies D012307:Risk Factors D012737:Sex Factors D016896:Treatment Outcome D014481:United States D014605:Uveitis D055815:Young Adult
side effects methotrexate uveitis hair loss Alopecia