Sex Differences in Diagnosis and Clinical Phenotypes of Chinese Children with Autism Spectrum Disorder.
The aim of this study was to explore the differences between boys and girls in the diagnosis and clinical phenotypes of autism spectrum disorder (ASD) in China's mainland. Children diagnosed with ASD (n = 1064, 228 females) were retrospectively included in the analysis. All children were assessed using the Autism Diagnostic Interview-Revised (ADI-R) and Autism Diagnostic Observation Schedule (ADOS). The results showed that girls scored significantly higher in ADI-R socio-emotional reciprocity than boys, and also scored lower in ADI-R and ADOS restricted and repetitive behaviors (RRBs). Meanwhile, the proportions of girls who satisfied the diagnostic cut-off scores in the ADI-R RRBs domain were lower than in boys (P < 0.05). Our results indicated that girls with ASD show greater socio-emotional reciprocity than boys. Girls also tended to show fewer RRBs than boys, and the type of RRBs in girls differ from those in boys. The ADI-R was found to be less sensitive in girls, particularly for assessment in the RRBs domain.
['Wang|Shihuan|S|', 'Deng|Hongzhu|H|', 'You|Cong|C|', 'Chen|Kaiyun|K|', 'Li|Jianying|J|', 'Tang|Chun|C|', 'Ceng|Chaoqun|C|', 'Zou|Yuanyuan|Y|', 'Zou|Xiaobing|X|']
D000067877:Autism Spectrum Disorder D002648:Child D002675:Child, Preschool D002681:China D003142:Communication D002658:Developmental Disabilities D005260:Female D006801:Humans D007398:Interpersonal Relations D008297:Male D010641:Phenotype D011569:Psychiatric Status Rating Scales D012189:Retrospective Studies D012727:Sex Characteristics D018709:Statistics, Nonparametric D013239:Stereotyped Behavior
Sex differences Diagnosis Autism spectrum disorder