Hepatopulmonary syndrome.
The hepatopulmonary syndrome (HPS) is a pulmonary complication of cirrhosis and/or portal hypertension whereby patients develop hypoxemia as a result of alterations in pulmonary microvascular tone and architecture. HPS occurs in up to 30% of patients with cirrhosis. Although the degree of hypoxemia does not reliably correlate with the severity of liver disease, patients with HPS have a higher mortality than do patients with cirrhosis without the disorder. There has been progress into defining the mechanisms that lead to hypoxemia in HPS, but to date there are no therapeutic options for HPS aside from liver transplantation.
['Koch|David G|DG|', 'Fallon|Michael B|MB|']
D000818:Animals D003937:Diagnosis, Differential D004195:Disease Models, Animal D020065:Hepatopulmonary Syndrome D006801:Humans D006975:Hypertension, Portal D000860:Hypoxia D008103:Liver Cirrhosis D016031:Liver Transplantation D019168:Portasystemic Shunt, Transjugular Intrahepatic D011652:Pulmonary Circulation D051381:Rats D014664:Vasodilation
Hepatopulmonary syndrome Portal hypertension Hypoxemia Liver transplantation Contrast echocardiography Intrapulmonary vasodilatation