The effectiveness of NEPA in the prevention of chemotherapy-induced nausea vomiting among chemo naive patients in an Indian setting.
BACKGROUND
Chemotherapy induced nausea- vomiting (CINV) is considered as the most common, feared and most troublesome side effect of chemotherapy. NEPA (NEtupitant 300 mg + PAlonosetron 0.50 mg) is the first commercially available oral fixed-dose combination (FDC) of two active antiemetic agents in India. The present study was planned to evaluate the effectiveness of NEPA in the real world setting of India.


METHODS
This was a multicentric retrospective study conducted in two centers in India. The data of all chemonaive patients, who were prescribed NEPA was analyzed. Effectiveness i.e. complete response and complete protection in controlling overall, acute and delayed phase was analyzed.


RESULTS
A total of 329 patients were enrolled in the study. 260 received highly emetogenic chemotherapy (HEC) regimen and 69 received moderately emetogenic chemotherapy (MEC) regimen. Among all the enrolled patients, complete response in acute, delayed and overall phase was 93, 85.71 and 85.41% respectively; and completed protection was 88.44, 81.76 and 80.54% respectively. Those who received HEC regimen, the completed response and complete protection in overall phase was 84.61 and 79.61% respectively and those who received MEC regimen the completed response and complete control in overall phase was 84.05 and 84.05% respectively.


CONCLUSION
A single oral dose of NEPA targeting dual pathways showed effective control of nausea-vomiting in patients on the HEC and MEC regimens and had good control over nausea-vomiting in acute, delayed and overall phase of nausea-vomiting.
['Vaswani|Bharat|B|', 'Dattatreya|Palanki Satya|PS|', 'Bhagat|Sagar|S|http://orcid.org/0000-0002-3513-4944', 'Patil|Saiprasad|S|', 'Barkate|Hanmant|H|']
D000328:Adult D000368:Aged D000932:Antiemetics D000970:Antineoplastic Agents D004338:Drug Combinations D005260:Female D006801:Humans D007194:India D007546:Isoquinolines D008297:Male D008875:Middle Aged D009325:Nausea D009369:Neoplasms D011725:Pyridines D011812:Quinuclidines D012189:Retrospective Studies D016896:Treatment Outcome D014839:Vomiting
NEPA Nausea Vomiting India HEC MEC