Decarboxylative alkynylation and carbonylative alkynylation of carboxylic acids enabled by visible-light photoredox catalysis.
Visible-light-induced photocatalytic decarboxylative alkynylations of carboxylic acids have been developed for the first time. The reaction features extremely mild conditions, broad substrate scope, and avoids additional oxidants. Importantly, a decarboxylative carbonylative alkynylation has also been carried out in the presence of carbon monoxide (CO) under photocatalytic conditions, which affords valuable ynones in high yields at room temperature.
['Zhou|Quan-Quan|QQ|', 'Guo|Wei|W|', 'Ding|Wei|W|', 'Wu|Xiong|X|', 'Chen|Xi|X|', 'Lu|Liang-Qiu|LQ|', 'Xiao|Wen-Jing|WJ|']
D000480:Alkynes D002264:Carboxylic Acids D002384:Catalysis D008027:Light D010084:Oxidation-Reduction
decarboxylation alkynylation carbonylation photocatalysis visible light