Distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle.
Both brown adipose tissue and skeletalmuscle have abundant mitochondria and energy consumption capacity. They are similar in origin and gain different potential of energy metabolism after differentiation and maturation. The mechanism that cause the difference is not yet fully understood. Long non-coding RNAs (lncRNAs) which comprise the bulk of the human non-coding transcriptome have been proved to play key roles in various biological processes. Whether they will have a function on the differentiation and energy metabolism between BAT and skeletalmuscle is still unknown. To identify the cellular long noncoding RNAs (lncRNAs) involved in the progress, we used the next generation transcriptome sequencing and microarray techniques, and investigated 704 up-regulated and 896 down-regulated lncRNAs (fold-change >3.0) in BAT by comparing the expression profile. Furthermore, we reported AK003288 associated with junctophilin 2 (Jph2) gene which may affect energy metabolism. This study show distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle which provide information for further research on differentiation of adipocyte and transdifferentiation between BAT and skeletalmuscle that will be helpful to find a new therapeutic target for combatting obesity.
['Zhang|Jun|J|', 'Cui|Xianwei|X|', 'Shen|Yahui|Y|', 'Pang|Lingxia|L|', 'Zhang|Aiqing|A|', 'Fu|Ziyi|Z|', 'Chen|Jiantao|J|', 'Guo|Xirong|X|', 'Gan|Weihua|W|', 'Ji|Chenbo|C|']
D002001:Adipose Tissue, Brown D000818:Animals D019295:Computational Biology D020869:Gene Expression Profiling D005786:Gene Expression Regulation D063990:Gene Ontology D006801:Humans D051379:Mice D008810:Mice, Inbred C57BL D018482:Muscle, Skeletal D020411:Oligonucleotide Array Sequence Analysis D062085:RNA, Long Noncoding D060888:Real-Time Polymerase Chain Reaction D015398:Signal Transduction
Brown adipose tissue Skeletalmuscle Long non-coding RNA Microarray