Electrospun alginate nanofibres impregnated with silver nanoparticles: Preparation, morphology and antibacterial properties.
Silver nanoparticles are amongst the most valuable nanoparticles with interesting properties, such as a non-toxic nature and high antibacterial efficiency, making them applicable for tissue scaffold, protective clothing and wound dressing. In this study, silver nanoparticles (AgNPs) have been synthesized using chitosan as reducing and stabilizing agent. The formation of silver nanoparticles was confirmed by UV-vis, and the TEM showed that different shapes were obtained depending on the heating duration. The chitosan/AgNPs was coated onto an electrospun alginate membrane to produce stable polyelectrolyte complex (PEC) nanofibre composites with high antibacterial efficiency. These composites were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). AgNPs were successfully impregnated into the PEC nanofibre composite, while there was complexation between the electrospun alginate and the chitosan/AgNPs composite. PEC demonstrated a good antibacterial activity against both gram negative and gram positive bacteria with acceptable water vapour transmission within the range required for the treatment of injuries or wounds.
['Mokhena|T C|TC|', 'Luyt|A S|AS|']
D000464:Alginates D000900:Anti-Bacterial Agents D048271:Chitosan D020723:Glucuronic Acid D006603:Hexuronic Acids D053768:Metal Nanoparticles D057139:Nanofibers D012834:Silver
Electrospun alginate Silver nanoparticles Chitosan Polyelectrolyte complex Antibacterial activity Acetic acid (PubChem CID: 176) Calcium chloride (PubChem CID: 5284359) Dimethylsulfoxide (PubChem CID: 24893881) Poly(ethylene oxide) (PubChem CID: 24863166) Triton™-X100 (PubChem CID: 24889888)