Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness.
A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections (ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls. Prediction of the patients' outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level.
['Chen|Ping|P|', 'Xie|Qiuyou|Q|', 'Wu|Xiaoyan|X|', 'Huang|Huiyuan|H|', 'Lv|Wei|W|', 'Chen|Lixiang|L|', 'Guo|Yequn|Y|', 'Zhang|Shufei|S|', 'Hu|Huiqing|H|', 'Wang|You|Y|', 'Nie|Yangang|Y|', 'Yu|Ronghao|R|', 'Huang|Ruiwang|R|']
D000328:Adult D001499:Bayes Theorem D063132:Connectome D003244:Consciousness Disorders D005260:Female D006801:Humans D000069550:Machine Learning D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D009434:Neural Pathways D011379:Prognosis D016548:Prosencephalon D055815:Young Adult
Spectral dynamic causal modeling Connectome-based predictive modeling Posterior cingulate cortex Mesocircuit Basal ganglia