Species Identification and Resistance Status of Anopheles gambiae s.l. (Diptera: Culicidae) Mosquitoes in Guinea.
Insecticide resistance is one of the primary threats to the recent gains in malaria control. This is especially true in Guinea, where long-lasting insecticidal nets are currently the primary vector control intervention. To better inform the national malaria control program on the current status of insecticide resistance in Guinea, resistance bioassays were conducted, using Anopheles gambiae s.l. Giles, in three sites. Molecular analyses were also done on An. gambiae s.l. to determine the species and find whether the target-site mutations kdr and Ace1R were present. Susceptibility tests revealed resistance to DDT and pyrethroids, although mosquitoes were susceptible to deltamethrin in two of the three sites tested. Mosquitoes were susceptible to bendiocarb, except in Kissidougou, Guinea. The kdr-west mutation was widespread and the frequency was 60% or more in all sites. However, the Ace1R mutation was present in low levels. Insecticide susceptibility should continue to be monitored in Guinea to ensure insecticide-based vector control methods remain effective.
['Keita|K|K|', 'Camara|D|D|', 'Barry|Y|Y|', 'Ossè|R|R|', 'Wang|L|L|', 'Sylla|M|M|', 'Miller|D|D|', 'Leite|L|L|', 'Schopp|P|P|', 'Lawrence|G G|GG|', 'Akogbéto|M|M|', 'Dotson|E M|EM|', 'Guilavogui|T|T|', 'Keita|M|M|', 'Irish|S R|SR|']
D000818:Animals D000852:Anopheles D005260:Female D005819:Genetic Markers D016701:Guinea D019476:Insect Proteins D007305:Insecticide Resistance D007306:Insecticides D009032:Mosquito Control
Anopheles gambiae Guinea kdr Ace1R Anopheles coluzzii