Drug release behavior of poly (lactic-glycolic acid) grafting from sodium alginate (ALG-g-PLGA) prepared by direct polycondensation.
Hydrophobically modified sodium alginate, poly (lactic-glycolic acid) grafting from sodium alginate (ALG-g-PLGA), was successfully synthesized through direct one-step polymerization of sodium alginate, glycolic acid, and lactic acid. ALG-g-PLGA self-assembled to colloidal nanoparticles and subsequently hydrogel microspheres were obtained by crosslinking ALG-g-PLGA nanoparticles in the solution of calcium chloride. The modified hydrogel microspheres could be used as the drug delivery vehicles for a hydrophobic ibuprofen. Compared with sodium alginate, ALG-g-PLGA demonstrated an improved drug loading rate, encapsulation efficiency, and prolonged release speed. The products, as novel and highly promising biomaterials, have potential applications.
['Shi|Gang|G|', 'Ding|Yuanyuan|Y|', 'Zhang|Xin|X|', 'Wu|Luyan|L|', 'He|Fei|F|', 'Ni|Caihua|C|']
D000464:Alginates D000894:Anti-Inflammatory Agents, Non-Steroidal D002122:Calcium Chloride D003102:Colloids D003692:Delayed-Action Preparations D004337:Drug Carriers D004339:Drug Compounding D065546:Drug Liberation D004355:Drug Stability D006358:Hot Temperature D020100:Hydrogels D006863:Hydrogen-Ion Concentration D057927:Hydrophobic and Hydrophilic Interactions D007052:Ibuprofen D007202:Indicators and Reagents D019344:Lactic Acid D008855:Microscopy, Electron, Scanning D053758:Nanoparticles D054118:Nanospheres D011091:Polyesters D011100:Polyglycolic Acid D000077182:Polylactic Acid-Polyglycolic Acid Copolymer D013499:Surface Properties
sodium alginate direct polycondensation drug carrier hydrophobic modification