Psychopharmacology and Bariatric Surgery.
Currently, it has been demonstrated that psychotropic drugs, particularly antidepressants, are frequently prescribed for patients who seek bariatric surgery. Many bariatric surgery patients have a history of a mood disorder. Unlike medications for diabetes, hypertension or hyperlipidemia, which are generally reduced and at times discontinued, postsurgery antidepressants use is only slightly reduced. The Roux-en-Y procedure is most frequently associated with alteration in drug exposure. Medication disintegration, dissolution, absorption, metabolism and excretion have been found to be altered in postbariatric patients, although data are sparse at this time. This paper will review the current evidence regarding the effect of bariatric surgery on drug treatment including mechanism of interference as well as the extent of changes identified to date. Data will be presented as controlled trials followed by case series and reports.
['Roerig|James L|JL|', 'Steffen|Kristine|K|']
D000928:Antidepressive Agents D050110:Bariatric Surgery D018849:Controlled Clinical Trials as Topic D006801:Humans D019964:Mood Disorders D009765:Obesity D011600:Psychopharmacology D011619:Psychotropic Drugs
treatment experimental obesity pharmacotherapy physiology