Non-Melanoma Skin Cancers: Biological and Clinical Features.
Non-melanoma skin cancers (NMSCs) include basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and Merkel cell carcinoma (MCC). These neoplasms are highly diverse in their clinical presentation, as well as in their biological evolution. While the deregulation of the Hedgehog pathway is commonly observed in BCC, SCC and MCC are characterized by a strikingly elevated mutational and neoantigen burden. As result of our improved understanding of the biology of non-melanoma skin cancers, innovative treatment options including inhibitors of the Hedgehog pathway and immunotherapeutic agents have been recently investigated against these malignancies, leading to their approval by regulatory authorities. Herein, we review the most relevant biological and clinical features of NMSC, focusing on innovative treatment approaches.
['Cives|Mauro|M|0000-0002-3013-1816', 'Mannavola|Francesco|F|0000-0003-2623-4166', 'Lospalluti|Lucia|L|', 'Sergi|Maria Chiara|MC|', 'Cazzato|Gerardo|G|', 'Filoni|Elisabetta|E|', 'Cavallo|Federica|F|', 'Giudice|Giuseppe|G|', 'Stucci|Luigia Stefania|LS|', 'Porta|Camillo|C|', 'Tucci|Marco|M|0000-0003-4008-4897']
D000911:Antibodies, Monoclonal D000951:Antigens, Neoplasm D000074322:Antineoplastic Agents, Immunological D063646:Carcinogenesis D002280:Carcinoma, Basal Cell D015266:Carcinoma, Merkel Cell D002294:Carcinoma, Squamous Cell D002986:Clinical Trials as Topic D015972:Gene Expression Regulation, Neoplastic D053823:Hedgehog Proteins D006801:Humans D007167:Immunotherapy D061026:Programmed Cell Death 1 Receptor D015398:Signal Transduction D012878:Skin Neoplasms
skin cancer basal cell carcinoma squamous cell carcinoma Merkel cell carcinoma Hedgehog pathway anti-PD1 monoclonal antibodies immunotherapy