Asymptomatic hematuria associated with urinary polyomavirus infection in immunocompetent patients.
Unlike the case for immunodeficient patients, little is known about polyomavirus (PV) infection in immunocompetent patients. PV infection in immunocompetent individuals has been reported sporadically, but little is known about asymptomatic hematuria. To determine the clinical significance and prevalence of urinary PV infection in immunocompetent patients, a total of 95 individuals admitted to Seoul St. Mary's hospital were investigated. Sixty-four patients were enrolled for evaluation of asymptomatic hematuria, and 31 healthy individuals served as controls. Clinical screening for PV infection was performed by urine cytology analysis by liquid-based preparation and urine RT-PCR for BK virus (BKV) and JC virus (JCV), respectively. The average age of the patients in the PV(+) - and PV(-) -groups with asymptomatic hematuria were 60 years and 46 years, respectively. Urine cytology analysis revealed decoy cells in 37/64 hematuria patients (38.9%), but not in healthy controls. They were more prevalent in male patients. Eighty-two patients (86.3%) had PV viruria, viz., 54/64 patients in the hematuria group and 28/31 in the control group. Interestingly, 28/31 (90.3%) cases in the healthy control group were positive for PV viruria, which exceeded the number in the hematuria group (84.4%). PV viruria was associated primarily with JCV, rather than BKV. PV viruria, including JCV viruria, correlated with urine decoy cells and increased age. In conclusion, urinary PV infection is common in immunocompetent patients with asymptomatic hematuria and is age-related. These data may provide an insight into the pathogenesis and future treatment of asymptomatic hematuria associated with urinary PV infection in immunocompetent patients.
['Lee|Sung Hak|SH|', 'Hong|Sung Hoo|SH|', 'Lee|Ji Youl|JY|', 'Hwang|Tae Kon|TK|', 'Kim|Kyoung Suk|KS|', 'Lee|Hyoungnam|H|', 'Choi|Yeong Jin|YJ|']
D000328:Adult D000367:Age Factors D000368:Aged D000369:Aged, 80 and over D001739:BK Virus D005260:Female D006417:Hematuria D006801:Humans D007577:JC Virus D008297:Male D008875:Middle Aged D027601:Polyomavirus Infections D015995:Prevalence D012737:Sex Factors D014552:Urinary Tract Infections D014556:Urine D055815:Young Adult
polyomavirus immunocompetent BK virus JC virus decoy cells real-time PCR