Use of cidofovir with extracorporeal membrane oxygenation to treat adenovirus-associated acute respiratory distress syndrome in paediatric patients- a case series.
WHAT IS KNOWN AND OBJECTIVE
Reports of cidofovir dosing with extracorporeal membrane oxygenation (ECMO) support are limited. This case series describes our clinical experience and provides a literature review regarding cidofovir dosing in paediatric patients requiring ECMO support.


CASE SUMMARY
Three patients with adenovirus-associated acute respiratory distress syndrome (ARDS) were treated with cidofovir while requiring ECMO support. A 27-month-old patient was treated with cidofovir 1 mg/kg/dose three times weekly, and a 19-month-old patient and an 18-year-old patient were treated with cidofovir 5 mg/kg/dose weekly.


WHAT IS NEW AND CONCLUSION
This case series describes the dosing and positive clinical response of cidofovir in paediatric patients with adenovirus-associated ARDS requiring ECMO support.
['Le|Thao K|TK|', 'Brown|Brian K|BK|', 'Namtu|Katie C|KC|', 'Berman|David M|DM|', 'Kiskaddon|Amy L|AL|https://orcid.org/0000-0003-1651-3620']
D000257:Adenoviridae Infections D000293:Adolescent D000998:Antiviral Agents D002675:Child, Preschool D000077404:Cidofovir D003937:Diagnosis, Differential D015199:Extracorporeal Membrane Oxygenation D005260:Female D006801:Humans D007223:Infant D008297:Male D012128:Respiratory Distress Syndrome
acute respiratory distress syndrome paediatrics dosing regimen pharmacokinetics