Second malignancy versus recurrence after complete resection of thymoma.
Background Patients undergoing complete resection of thymoma occasionally develop a recurrence of thymoma; they are also at risk of developing a second malignancy. The objective of our study was to compare the incidence and mortality of a second malignancy versus a recurrence of thymoma during the postoperative follow-up period after complete resection of thymoma. Methods A retrospective chart review was performed on our prospectively maintained database to identify patients undergoing complete resection of thymoma at our institution between 1991 and 2016. The incidence and related mortality of a second malignancy or recurrence of thymoma were recorded. Results One hundred and sixty-four patients were identified. Follow-up ranged from 1 to 239 months (median 54 months). During follow-up, 12 patients had a recurrence of thymoma and 14 developed a second malignancy. The mean risk ratio of recurrence to second malignancy was 0.58 (95% confidence interval: 0.48-0.69) at 5 years, 0.58 (95% confidence interval: 0.49-0.68) at 10 years, and 0.51 (95% confidence interval: 0.43-0.60) at 15 years. The mean risk ratio of recurrence versus second malignancy for related death was 0.59 (95% confidence interval: 0.50-0.70) at 5 years and 0.61 (95% confidence interval: 0.52-0.72) at 10 years. Conclusion It appears that patients undergoing complete resection of thymoma have a higher incidence of a second malignancy and a greater related mortality rate than a recurrence of thymoma. A multiinstitutional database is required to more rigorously evaluate both risks and to confirm our results.
['Hamaji|Masatsugu|M|', 'Sozu|Takashi|T|', 'Machida|Ryunosuke|R|', 'Omasa|Mitsugu|M|', 'Menju|Toshi|T|', 'Aoyama|Akihiro|A|', 'Sato|Toshihiko|T|', 'Chen-Yoshikawa|Toyofumi-Fengshi|TF|', 'Sonobe|Makoto|M|', 'Date|Hiroshi|H|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D016208:Databases, Factual D005260:Female D006801:Humans D015994:Incidence D007564:Japan D008297:Male D008875:Middle Aged D009364:Neoplasm Recurrence, Local D016609:Neoplasms, Second Primary D016017:Odds Ratio D012189:Retrospective Studies D012307:Risk Factors D013934:Thymectomy D013945:Thymoma D013953:Thymus Neoplasms D013997:Time Factors D016896:Treatment Outcome D055815:Young Adult
Thymoma Incidence Myasthenia gravis Neoplasm recurrence Neoplasms Thymectomy local second primary