Lactadherin: An unappreciated haemostasis regulator and potential therapeutic agent.
Lactadherin is a small (53-66kDa) multifunctional glycoprotein belonging to the secreted extracellular matrix protein family. It has a multi-domain structure and is involved in many biological and physiological processes, including phagocytosis, angiogenesis, atherosclerosis, tissue remodeling, and haemostasis regulation. Lactadherin binds phosphatidylserine (PS)-enriched cell surfaces in a receptor-independent manner. Interaction between lactadherin and PS is crucial for regulation of blood coagulation processes. This review summarizes recent knowledge on the possible role of lactadherin in haemostasis control, emphasizing the great significance of the interaction between lactadherin and PS expressed on activated platelets and extracellular vesicles. The possible role of lactadherin as a therapeutic target and biomarker is also discussed.
['Kamińska|Agnieszka|A|', 'Enguita|Francisco J|FJ|', 'Stępień|Ewa Ł|EŁ|']
D000818:Animals D000925:Anticoagulants D000954:Antigens, Surface D001665:Binding Sites D001792:Blood Platelets D000067128:Extracellular Vesicles D006487:Hemostasis D006801:Humans D008894:Milk Proteins D008958:Models, Molecular D010718:Phosphatidylserines D015539:Platelet Activation D011487:Protein Conformation D015398:Signal Transduction D013329:Structure-Activity Relationship
Phosphatidylserine Coagulation MFG-E8 Microvesicles RGD