A nanotechnology based new approach for Trypanosoma evansi chemotherapy: In vitro and vivo trypanocidal effect of (-)-α-bisabolol.
The aim of this study was to evaluate the in vitro and in vivo susceptibility of Trypanosoma evansi to α-Bisabolol and solid lipid nanoparticles containing α-Bisabolol (SLN-B). In vitro, a trypanocidal effect of α-Bisabolol and SLN-B was observed when used at 0.5, 1 and 2% concentrations, i.e., the concentrations of 1 and 2% showed a faster trypanocidal effect when compared to chemotherapy (diminazene aceturate - D.A.). T. evansi infected mice were treated with α-Bisabolol and SLN-B at a dose of 1.0 mL kg-1 during seven days via oral gavage. In vivo, treatment with SLN-B, D.A. and D.A. associated with SLN-B were able to increase (p < 0.05) the pre-patent period and longevity when compared to positive control (infected and untreated animals), but showed no curative efficacy. T. evansi infected mice treated with D.A. associate with SLN-B, where a curative efficacy of 50% was found, a much better result when D. A and SLN-B were used alone (16.66%). In summary, the association with D. A + SLN-B can be used as an alternative to improve the therapeutic effectiveness of D.A., and for treatment of infected animals with T. evansi. Also, the nanotechnology associated with natural products arises an important alternative for the improve the trypanocidal action.
['Baldissera|Matheus D|MD|', 'Grando|Thirssa H|TH|', 'de Souza|Carine F|CF|', 'Cossetin|Luciana F|LF|', 'da Silva|Ana P T|APT|', 'Giongo|Janince L|JL|', 'Monteiro|Silvia G|SG|']
D000818:Animals D004285:Dogs D005260:Female D008055:Lipids D051379:Mice D000081222:Monocyclic Sesquiterpenes D053758:Nanoparticles D010316:Particle Size D051381:Rats D012717:Sesquiterpenes D013997:Time Factors D014345:Trypanosoma D014352:Trypanosomiasis
Nanotechnology Alternative treatment “Surra”