The association between serum albumin/prealbumin level and disease severity in non-CF bronchiectasis.
Non-cystic fibrosis (non-CF) bronchiectasis is a chronic pulmonary disease that can lead to malnutrition. Serum prealbumin and albumin level are related to inflammatory and nutritional status. Thus, we aimed to confirm our hypothesis that low serum albumin and prealbumin level, as well as body mass index (BMI), is correlated to severe non-CF bronchiectasis. We conducted a retrospective cross-sectional study of 128 patients, including 75 patients with prealbumin test and 79 patients with albumin test. Detailed medical history was recorded, including pulmonary function tests and high-resolution computed tomography. bronchiectasis severity index (BSI) and FACED scores were calculated. Leicester Cough Questionnaire, Quality of Life Questionnaire-Bronchiectasis, chronic obstructive pulmonary disease (COPD) assessment test and Patient Health Questionnaire-9 questionnaires were used to assess patients' clinical symptoms. Correlation analysis showed that BSI score was more correlated to patients' clinical symptoms than FACED. Thus, patients were divided into three groups of different severity based on BSI score. Albumin, prealbumin and BMI showed a significant difference between three groups. Correlation and multivariable linear regression analysis showed that serum albumin and prealbumin level were correlated to BSI, FACED and questionnaires. The analysis between three indices and PFT/high-resolution computed tomography (HRCT) showed that prealbumin, albumin and BMI could reflect the PFT and modified Reiff score in non-CF bronchiectasis. In conclusion, BMI, albumin and prealbumin showed a significant correlation with the BSI, FACED, as well as patients' clinical symptoms. Among them, serum albumin was the indicator most strongly associated with the BSI and questionnaires, while prealbumin could better reflect lung function decline and radiological severity.
['Li|Liyang|L|', 'Li|Zhuozhe|Z|', 'Bi|Jing|J|', 'Li|Huayin|H|', 'Wang|Sijiao|S|', 'Shao|Changzhou|C|0000-0002-1174-2654', 'Song|Yuanlin|Y|']
D000328:Adult D000368:Aged D015415:Biomarkers D001987:Bronchiectasis D003430:Cross-Sectional Studies D005260:Female D006801:Humans D008168:Lung D008297:Male D008875:Middle Aged D011228:Prealbumin D011237:Predictive Value of Tests D011379:Prognosis D011788:Quality of Life D012129:Respiratory Function Tests D012189:Retrospective Studies D000075462:Serum Albumin, Human D012720:Severity of Illness Index D011795:Surveys and Questionnaires
albumin prealbumin non-CF bronchiectasis body mass index