Normal fertility in male mice lacking ADAM32 with testis-specific expression.
The a disintegrin and metalloprotease (ADAM) family proteins comprise a group of membrane-anchored proteins. ADAM32 is expressed specifically in testis and is closely related phylogenetically to ADAM2 and ADAM3, which are known to be critical for fertilization in mice. To assess the biological role of ADAM32, we analyzed Adam32-mutant mice. We found that male mice lacking ADAM32 have normal fertility, testicular integrity, and sperm characteristics. ADAM32 was found to exist at lower levels than ADAM2 and ADAM3 in wild-type testis and sperm, respectively. The present study demonstrates that ADAM32 is dispensable for fertility and appears to be functionally unrelated to ADAM2 and ADAM3 in mice.
['Lee|Seonhee|S|', 'Hong|Seong Hyeon|SH|', 'Cho|Chunghee|C|']
D051722:ADAM Proteins D000818:Animals D001947:Breeding D004822:Epididymis D005260:Female D000072196:Fertilins D005298:Fertility D015870:Gene Expression D008297:Male D008562:Membrane Glycoproteins D051379:Mice D008810:Mice, Inbred C57BL D018345:Mice, Knockout D013081:Sperm Motility D013094:Spermatozoa D013737:Testis
Fertilization ADAM32 A disintegrin and metalloprotease Testis Sperm