Impact of pre-operative serum 25-hydroxyvitamin D on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre: retrospective study of 246 patients.
OBJECTIVE
To determine whether pre-operative serum 25-hydroxyvitamin D has an impact on post-operative parathyroid hormone and serum calcium levels in patients undergoing total thyroidectomy for benign goitre.


METHODS
This single-centre, retrospective study comprised 246 unselected surgical patients who had undergone total thyroidectomy for bilateral, benign, multinodular goitre. The correlation between pre-operative serum 25-hydroxyvitamin D and post-operative serum parathyroid hormone and serum calcium was studied to determine whether low pre-operative serum 25-hydroxyvitamin D was predictive of post-operative hypocalcaemia.


RESULTS
Seventy-nine patients (32 per cent) had post-operative hypocalcaemia. Eighteen patients (7.32 per cent) experienced unintentional parathyroidectomy (1 parathyroid gland in 15 patients, 2 parathyroid glands in 3 patients). In univariate analysis, pre-operative serum 25-hydroxyvitamin D was not correlated with post-operative serum calcium (p = 0.69) or post-operative serum parathyroid hormone (p = 0.5804). Furthermore, in multivariate analysis, which took into account unintentional parathyroidectomy, no correlation was found (p = 0.33). Bilateral unintentional parathyroidectomy was statistically associated with post-operative hypocalcaemia (p = 0.032).


CONCLUSION
Pre-operative serum 25-hydroxyvitamin D did not appear to have any impact on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre.
['Erlem|M|M|', 'Klopp-Dutote|N|N|', 'Biet-Hornstein|A|A|', 'Strunski|V|V|', 'Page|C|C|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D002118:Calcium D005260:Female D006044:Goiter, Nodular D006801:Humans D006996:Hypocalcemia D008297:Male D008875:Middle Aged D016105:Parathyroidectomy D012189:Retrospective Studies D013965:Thyroidectomy D016896:Treatment Outcome D014807:Vitamin D D055815:Young Adult
Thyroidectomy Parathyroid Hormone Hypocalcemia Hypoparathyroidism Vitamin D