Neutrophil-to-Lymphocyte Ratio Is a Prognostic Marker in Acute Ischemic Stroke.
BACKGROUND
Neutrophil-to-lymphocyte ratio is an independent predictor of mortality in patients with acute ischemic stroke. However, it is uncertain whether neutrophil-to-lymphocyte ratio is related with functional outcome and recurrent ischemic stroke. In this study, we aimed to investigate the relationship of neutrophil-to-lymphocyte ratio with stroke severity, functional outcome, and recurrent ischemic stroke after acute ischemic stroke.


METHODS
A total of 280 patients with acute ischemic stroke were included in the study. Patients were divided into 3 groups according to the neutrophil-to-lymphocyte ratio value (<2, 2-3, >3). Demographic, clinical, and laboratory data were collected for all patients. We evaluated the association between neutrophil-to-lymphocyte ratio and (1) stroke severity on admission, (2) functional outcome at 3 months, and (3) recurrent ischemic stroke. Regression analyses were performed, adjusting for confounders.


RESULTS
After adjustment for potential confounders, neutrophil-to-lymphocyte ratio was associated with an increased risk of stroke severity on admission (odds ratio [OR] 1.364, 95% confidence interval [CI] 1.101-1.690, P = .005) and primary unfavorable outcome (OR 1.455, 95% CI 1.083-1.956, P = .013). After a median of 1.13 years (interquartile range.91-1.42) of follow-up, neutrophil-to-lymphocyte ratio was associated with recurrent ischemic stroke after adjustment (hazard ratio 1.499, 95% CI 1.161-1.935, P = .002).


CONCLUSIONS
Our study suggests that neutrophil-to-lymphocyte ratio is associated with stroke severity on admission, primary unfavorable functional outcome, and recurrent ischemic stroke in patients with acute ischemic stroke.
['Xue|Jie|J|', 'Huang|Wensi|W|', 'Chen|Xiaoli|X|', 'Li|Qian|Q|', 'Cai|Zhengyi|Z|', 'Yu|Tieer|T|', 'Shao|Bei|B|']
D000368:Aged D001786:Blood Glucose D002545:Brain Ischemia D002097:C-Reactive Protein D002784:Cholesterol D004562:Electrocardiography D005215:Fasting D005260:Female D006801:Humans D008074:Lipoproteins D008214:Lymphocytes D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D009504:Neutrophils D011379:Prognosis D012307:Risk Factors D012720:Severity of Illness Index D020521:Stroke
Neutrophil-to-lymphocyte ratio acute ischemic stroke inflammation prognosis