The intersect of neurosurgery with diffuse intrinsic pontine glioma.
An invited article highlighting diffuse intrinsic pontine glioma (DIPG) to celebrate the 75th Anniversary of the Journal of Neurosurgery, a journal known to define surgical nuance and enterprise, is paradoxical since DIPG has long been relegated to surgical abandonment. More recently, however, the neurosurgeon is emerging as a critical stakeholder given our role in tissue sampling, collaborative scientific research, and therapeutic drug delivery. The foundation for this revival lies in an expanding reliance on tissue accession for understanding tumor biology, available funding to fuel research, and strides with interventional drug delivery.
['Kuzan-Fischer|Claudia M|CM|', 'Souweidane|Mark M|MM|']
D001706:Biopsy D001812:Blood-Brain Barrier D020295:Brain Stem Neoplasms D018481:Convection D000080443:Diffuse Intrinsic Pontine Glioma D016503:Drug Delivery Systems D006801:Humans D007261:Infusions, Intra-Arterial D008279:Magnetic Resonance Imaging D009493:Neurosurgery D019635:Neurosurgical Procedures D013238:Stereotaxic Techniques D014464:Ultrasonic Therapy
DIPG BBB = blood-brain barrier CED = convection-enhanced delivery DIPG = diffuse intrinsic pontine glioma MRgFUS = MR-guided focused ultrasound biopsy brainstem glioma diffuse pontine glioma oncology surgery