Manometric assessment of esophageal motor function in patients with primary biliary cirrhosis.
INTRODUCTION/AIM
Primary biliary cirrhosis is associated with other autoimmune diseases including Sjögren's syndrome, and scleroderma. Esophageal dysmotility is well known in scleroderma, and Sjögren's syndrome. The aim of this study is to investigate whether any esophageal motor dysfunction exists in patients with primary biliary cirrhosis.


METHOD
The study was performed in 37 patients (36 women, mean age: 56.29 ± 10.01 years) who met diagnostic criteria for primary biliary cirrhosis. Thirty-seven functional dyspepsia patients, were also included as a control group. Patients entering the study were asked to complete a symptom questionnaire. Distal esophageal contraction amplitude, and lower esophageal sphincter resting pressure were assessed.


RESULTS
Manometric findings in primary biliary cirrhosis patients vs. controls were as follows: Median lower esophageal sphincter resting pressure (mmHg): (24 vs 20, p=0.033); median esophageal contraction amplitude (mmHg): (71 vs 56, p=0.050); mean lower esophageal sphincter relaxation duration (sc, x ± SD): (6.10 ± 1.18 vs 8.29 ± 1.92, p<0.001); and median lower esophageal sphincter relaxation (%) (96 vs 98, p=0.019); respectively. No significant differences were evident in median peak velocity (sc) (3.20 vs 3.02, p=0.778) between patients with primary biliary cirrhosis and the functional dyspepsia patients. Esophageal dysmotility was found in 17 (45.9%) primary biliary cirrhosis patients (non-specific esophageal motor disorder in ten patients, hypomotility of esophagus in five patients, nutcracker esophagus in one patient and hypertensive lower esophageal sphincter in one patient).


CONCLUSION
Esophageal dysmotility was detected in 45.9% of patients. The study suggests that subclinic esophageal dysmotility is frequent in patients with primary biliary cirrhosis.
['Bektas|Mehmet|M|', 'Seven|Gulseren|G|', 'Idilman|Ramazan|R|', 'Yakut|Mustafa|M|', 'Doğanay|Beyza|B|', 'Kabacam|Gökhan|G|', 'Ustun|Yusuf|Y|', 'Korkut|Esin|E|', 'Kalkan|Çağdaş|Ç|', 'Sahin|Günay|G|', 'Cetinkaya|Hulya|H|', 'Bozkaya|Hakan|H|', 'Yurdaydin|Cihan|C|', 'Bahar|Kadir|K|', 'Cinar|Kubilay|K|', 'Soykan|Irfan|I|']
D000328:Adult D000368:Aged D004415:Dyspepsia D015154:Esophageal Motility Disorders D005260:Female D006801:Humans D008105:Liver Cirrhosis, Biliary D008297:Male D008365:Manometry D008875:Middle Aged
Primary biliary cirrhosis Sjögren's syndrome Esophageal motility