Species-specific models in toxicology: in vitro epithelial barriers.
Species-specific in vitro epithelial barriers represent interesting predictive tools for risk assessment evaluation in toxicological studies. Moreover, these models could be applied either as stand-alone methods for the study of absorption, bioavailability, excretion, transport, effects of xenobiotics, or through an Integrated Testing Strategy. The aim of this review is to give a comprehensive overview of in vitro species-specific epithelial barrier models from bovine, dog and swine. Bovine mammary epithelial barrier as a fundamental instrument for the evaluation of the toxicant excretion, the blood brain barrier as a useful first approach in toxicological and pharmacological studies, the porcine intestinal barrier, the canine skin barrier, and finally the pulmonary barrier from bovine and swine species are described in this review.
['Bertero|A|A|', 'Augustyniak|J|J|', 'Buzanska|L|L|', 'Caloni|F|F|']
D000818:Animals D001812:Blood-Brain Barrier D004848:Epithelium D005260:Female D006801:Humans D007422:Intestines D008168:Lung D008321:Mammary Glands, Animal D008954:Models, Biological D012867:Skin D013045:Species Specificity
Species-specific Toxicology in vitro Barriers