Metabolomics in Radiation-Induced Biological Dosimetry: A Mini-Review and a Polyamine Study.
In this study, we elucidate that polyamine metabolite is a powerful biomarker to study post-radiation changes. Metabolomics in radiation biodosimetry, the application of a metabolomics analysis to the field of radiobiology, promises to increase the understanding of biological responses by ionizing radiation (IR). Radiation exposure triggers a complex network of molecular and cellular responses that impacts metabolic processes and alters the levels of metabolites. Such metabolites have potential as biomarkers for radiation dosimetry. Among metabolites, polyamine is one of many potential biomarkers to estimate radiation response. In addition, this review provides an opportunity for the understanding of a radiation metabolomics in biodosimetry and a polyamine case study.
['Roh|Changhyun|C|0000-0002-0542-4828']
D000818:Animals D015415:Biomarkers D015374:Biosensing Techniques D006801:Humans D055442:Metabolome D055432:Metabolomics D011073:Polyamines D011832:Radiation Injuries D011839:Radiation, Ionizing D011874:Radiometry
metabolomics polyamines biomarker radiation biodosimetry ionizing radiation