A novel strategy for fabrication of fluorescent hydroxyapatite based polymer composites through the combination of surface ligand exchange and self-catalyzed ATRP.
A novel and facile strategy that combination of surface ligand exchange and photo-initiated atom transfer radical polymerization (ATRP) has been developed for the preparation of fluorescent hydroxyapatite (HAp) based polymer composites, which were utilized for biological imaging applications. In particular, the photo-initiated ATRP not only inherited advantages of traditional ATRP but also overcome its deficiencies such as high energy consumption, transition metal contamination and long reaction time. In this method, a hydrophilic and biocompatible PEGMA was introduced to enhance the hydrophilic and biocompatibility of HAp nanocomposites. Simultaneously, the HAp-poly(PEGMA-co-AcFl) composites are endowed with bright green fluorescence by grafting with AcFl on the surface via copolymerization. The physicochemical properties of HAp-poly(PEGMA-co-AcFl) composites were characterized by a series of methods in detail. Results confirmed that HAp-poly(PEGMA-co-AcFl) composites possess controlled size and morphology, high water dispersibility and strong fluorescence. The cell viability and cell uptake behavior demonstrated that HAp-poly(PEGMA-co-AcFl) composites present low toxicity and can be potentially used for biological imaging. Taken together, we have developed a facile and efficient method for the fabrication of fluorescent HAp composites with desirable physicochemical and biological properties.
['Chen|Junyu|J|', 'Liu|Meiying|M|', 'Huang|Qiang|Q|', 'Jiang|Ruming|R|', 'Huang|Hongye|H|', 'Deng|Fengjie|F|', 'Wen|Yuanqing|Y|', 'Tian|Jianwen|J|', 'Zhang|Xiaoyong|X|', 'Wei|Yen|Y|']
D000818:Animals D002460:Cell Line D017886:Durapatite D005347:Fibroblasts D008422:Materials Testing D008689:Methacrylates D051379:Mice D053761:Nanocomposites D055668:Photochemical Processes D011092:Polyethylene Glycols
Fluorescent hydroxyapatite Polymer composites Biological imaging Photo-initiated ATRP