Sarcopenia in Hodgkin's lymphoma evaluated with 18-FDG PET/CT, focus on age, performance, and treatment.
Sarcopenia is defined as a progressive and generalized muscle disorder associated with certain physiological and pathological conditions. We aimed to evaluate the prevalence of sarcopenia in patients with HL using 18-fluoro deoxyglucose (FDG) PET/CT, which would provide a data of muscle mass with the CT compartment and also data of muscle metabolism with the 18-FDG compartment of the imaging modality. Fifty-nine patients diagnosed with HL were included in the study. PET/CT images before and after treatment were evaluated with regard to lumbar muscle mass and metabolism. Mean lumbar muscle evaluation with CT before treatment was 92, 40 HU, and after treatment was 89, 41 HU. Mean metabolic tumor volume (MTV) evaluated with FDG PET before treatment was 4, 13 mm3 while after treatment was 4, 10 mm3. The lumbar muscle mass in terms of HU which was evaluated with CT was observed to be decreased after treatment. Likewise, the metabolic evaluation was observed to be also decreased after treatment. Despite the decline in muscle mass after treatment in the whole group, this decline was particularly observed in the better initial performance group. In patients with BMI > 32, there was a significant decline in muscle mass. Abdominal nodal involvement was related with poorer muscle mass and quality. In HL care, particular attention should be given to patients who are younger and with better physical condition in terms of preserving the muscle reserves and preventing sarcopenia.
['Bas|Volkan|V|https://orcid.org/0000-0003-1391-3784', 'Umit|Elif Gulsum|EG|https://orcid.org/0000-0001-5589-3000', 'Korkmaz|Ulku|U|https://orcid.org/0000-0002-7155-7610', 'Baysal|Mehmet|M|https://orcid.org/0000-0001-7681-4623', 'Karaman Gulsaran|Sedanur|S|https://orcid.org/0000-0002-1565-3341', 'Demirci|Ufuk|U|https://orcid.org/0000-0001-6923-1470', 'Kirkizlar|Hakki Onur|HO|https://orcid.org/0000-0001-7523-8599', 'Durmus Altun|Gulay|G|https://orcid.org/0000-0002-9773-5390', 'Demir|Ahmet Muzafer|AM|https://orcid.org/0000-0002-2073-5405']
D000328:Adult D000367:Age Factors D000368:Aged D005260:Female D019788:Fluorodeoxyglucose F18 D006689:Hodgkin Disease D006801:Humans D008297:Male D008875:Middle Aged D000072078:Positron Emission Tomography Computed Tomography D055948:Sarcopenia D055815:Young Adult
Sarcopenia 18-FDG PET/CT Muscle Hodgkin’s lymphoma