LC-MS guided identification of dimeric 2-(2-phenylethyl)chromones and sesquiterpene-2-(2-phenylethyl)chromone conjugates from agarwood of Aquilaria crassna and their cytotoxicity.
Four previously unreported dimeric 2-(2-phenylethyl)chromones (1-4a) and three unprecedented sesquiterpene-2-(2-phenylethyl)chromone conjugates (5-7), comprising a sesquiterpenoid and a 5,6,7,8-tetrahydroxy-2-(2-phenylethyl)-5,6,7,8 -tetrahydro-4H-chromone moiety, as well as three known dimeric 2-(2-phenylethyl)chromones (4b, 8a, 8b) were identified from agarwood originating from Aquilaria crassna in Cambodia by LC-MS guided separation. Their structures were elucidated by extensive NMR techniques, HRESIMS and CD. All compounds were evaluated for their cytotoxicity against four human cancer cell lines. Compounds 6, 7, 8a, 8b displayed a range of cytotoxic activities with IC50 values in the rang 10.93-49.0 μM.
['Xia|Lulu|L|', 'Li|Wei|W|', 'Wang|Hao|H|', 'Chen|Huiqin|H|', 'Cai|Caihong|C|', 'Yang|Li|L|', 'Jiang|Bei|B|', 'Yang|Yiling|Y|', 'Mei|Wenli|W|', 'Dai|Haofu|H|']
D000972:Antineoplastic Agents, Phytogenic D002160:Cambodia D045744:Cell Line, Tumor D002853:Chromatography, Liquid D005419:Flavonoids D006801:Humans D013058:Mass Spectrometry D015394:Molecular Structure D064209:Phytochemicals D012717:Sesquiterpenes D029645:Thymelaeaceae D014934:Wood
Dimeric 2-(2-phenylethyl)chromone Sesquiterpene-2-(2-phenylethyl)chromone conjugate Agarwood Aquilaria crassna Cytotoxic activity