The impact of vascular endothelial growth factor +405 C/G polymorphism on long-term outcome and severity of coronary artery disease.
BACKGROUND
The association between genetic variations of vascular endothelial growth factor (VEGF) gene and the risk for atherosclerosis has been hypothesized. We aimed to assess the relationship between rs2010963 (+405 C/G) polymorphism and presence, severity, and outcome of coronary artery disease (CAD) in an Iranian cohort.


METHODS
Genotyping of VEGF rs2010963 polymorphism was performed on 520 individuals, comprising 347 patients with documented coronary artery disease based on angiography report and 173 individuals with normal coronary arteries, using the TaqMan real-time PCR method. In final, 484 subjects were followed up over a 5-year period for cardiovascular-related outcomes.


RESULTS
C allele of VEGF rs2010963 polymorphism was related to increase risk for CAD and also slightly to 5-year cardiovascular mortality. The 5-year survival in C and G allele subgroups were 92.3% and 94.3% in CAD group and 95.7% and 98.0% in non-CAD group, respectively.


CONCLUSIONS
Vascular endothelial growth factor rs2010963 polymorphism may be associated with the presence of CAD and its long-term survival, but not with its severity. To the best of our knowledge, this is the first report of genetic association between rs2010963 SNP and CAD-related death. It can be thus suggested that rs2010963 VEGF gene can be considered as a genetic risk predictor for CAD and its outcomes.
['Kalayi Nia|Samira|S|', 'Ziaee|Shayan|S|', 'Boroumand|Mohammad Ali|MA|', 'Sotudeh Anvari|Maryam|M|', 'Pourgholi|Leyla|L|', 'Jalali|Arash|A|']
D000368:Aged D003324:Coronary Artery Disease D005260:Female D005500:Follow-Up Studies D006801:Humans D008297:Male D008875:Middle Aged D020641:Polymorphism, Single Nucleotide D016019:Survival Analysis D042461:Vascular Endothelial Growth Factor A
vascular endothelial growth factor coronary artery disease gene mortality Gensini score