Protective effects of resveratrol against the cardiac developmental toxicity of trichloroethylene in zebrafish embryos.
Trichloroethylene (TCE), a prevalent environmental contaminant, has been shown to induce cardiac malformations. Resveratrol (RSV) is a natural polyphenolic compound exhibiting protective effects on heart development. To investigate if RSV could protect against TCE-induced heart defects, we exposed zebrafish embryos to TCE (10 ppb) in the presence or absence of RSV (1 μg/mL). Our results showed that RSV significantly attenuated TCE-induced heart defects in zebrafish embryos. The TCE-induced ROS (reactive oxygen species) generation, 8-OHdG (8-hydroxy-2`-deoxyguanosine) formation and cell proliferation were significantly counteracted by RSV. Moreover, RSV attenuated the TCE-induced changes in mRNA expression or activity of genes involved in AHR and Nrf2 signal pathways. We further showed that RSV might inhibit TCE-enhanced cell proliferation by rescuing the downregulation of the p53/p21 axis. In conclusion, our data demonstrates that RSV protects against the cardiac developmental toxicity of TCE by inhibiting AHR activity, oxidative stress and cell proliferation.
['Huang|Yujie|Y|', 'Xia|Ying|Y|', 'Tao|Yizhou|Y|', 'Jin|Hongmei|H|', 'Ji|Cheng|C|', 'Aniagu|Stanley|S|', 'Chen|Tao|T|', 'Jiang|Yan|Y|']
D000818:Animals D002316:Cardiotonic Agents D047108:Embryonic Development D006321:Heart D000077185:Resveratrol D012997:Solvents D014241:Trichloroethylene D015027:Zebrafish
Resveratrol Trichloroethylene Zebrafish Heart development AHR Oxidative stress