Clinical correlates of serum insulin-like growth factor-1 in patients with Parkinson's disease, multiple system atrophy and progressive supranuclear palsy.
BACKGROUND
Recently, increased serum insulin-like growth factor-1 (IGF-1) levels have been reported in patients with Parkinson's disease (PD) and multiple system atrophy (MSA).


OBJECTIVE
To assess a correlation between the serum IGF-1 levels and clinical background factors in patients with PD and related disorders such as MSA and progressive supranuclear palsy (PSP).


METHODS
A total of 79 PD patients, 25 MSA patients, 16 PSP patients and 52 healthy controls were included in this study. The serum IGF-1 and growth hormone (GH) levels were measured in a fasting state. Unified PD Rating Scale (UPDRS) part III was used to evaluate motor function. Unified MSA Rating Scale (UMSARS) part II was also employed for the MSA patients.


RESULTS
The serum IGF-1 levels were significantly increased in the MSA patients compared with the PD patients and controls. No significant differences were observed in the serum GH levels among the patients and controls. The serum IGF-1 levels of PD patients with Hoehn and Yahr stage 2 were significantly higher than those of patients with Hoehn and Yahr stages 3-5. In patients with PD and PSP, the serum IGF-1 levels were negatively correlated with UPDRS part III. In contrast, patients with MSA showed a positive correlation of the serum IGF-1 levels with disease duration, UPDRS part III and UMSARS part II.


CONCLUSION
The difference in the serum IGF-1 level and its correlation with clinical variables among these disorders may reflect different ongoing disease processes in each disorder.
['Numao|Ayaka|A|', 'Suzuki|Keisuke|K|', 'Miyamoto|Masayuki|M|', 'Miyamoto|Tomoyuki|T|', 'Hirata|Koichi|K|']
D000368:Aged D015415:Biomarkers D016022:Case-Control Studies D003430:Cross-Sectional Studies D004797:Enzyme-Linked Immunosorbent Assay D005260:Female D006801:Humans D007334:Insulin-Like Growth Factor I D008297:Male D008875:Middle Aged D019578:Multiple System Atrophy D010300:Parkinson Disease D013494:Supranuclear Palsy, Progressive
Insulin-like growth factor-1 Parkinson's disease Multiple system atrophy Progressive supranuclear palsy