Adipose tissue-derived stem cell therapy for erectile dysfunction in rats: a systematic review and meta-analysis.
OBJECTIVE
We aimed to systematically assess the effect of adipose tissue-derived stem cell (ADSC) therapy and its influential factors on the treatment of erectile dysfunction (ED) in rats.


METHODS
Two authors independently searched for published studies through PubMed and EMBASE from study inception until August 31, 2016. A meta-analysis was used to combine the effect estimate from the published studies. A subgroup analysis was performed to identify the effect of some influential factors. The pooled standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated by a fixed-effects or random-effects model analysis.


RESULTS
Twenty studies with a total of 248 rats were included in this meta-analysis. The pooled analysis showed that ADSC therapy significantly increased the ratio of intracavernous pressure and mean arterial pressure (ICP/MAP; SMD 3.46, 95% CI 2.85-4.06; P < 0.001) compared to control therapy. The levels of neuronal nitric oxide synthase (nNOS; SMD 6.37, 95% CI 4.35-8.39; P < 0.001), the cavernous smooth muscle content (CSMC; SMD 3.65, 95% CI 2.65-4.65; P < 0.001), the ratio of cavernous smooth muscle and collagen (CSM/collagen; SMD 4.16, 95% CI 2.59-5.72; P < 0.001), and the cyclic guanosine monophosphate (cGMP; SMD 7.12, 95% CI 2.76-11.48; P = 0.001) were higher following ADSC therapy than following control therapy. Subgroup analysis showed that ADSCs modified by growth or neurotrophic factors significantly recovered erectile function (P < 0.001) compared with ADSC therapy.


CONCLUSION
The adequate data indicated that ADSC therapy recovered erectile function and regenerated cavernous structures in ED rats, and ADSCs modified by some growth and neurotrophic factors accelerated the recovery of erectile function and cavernous structures in ED rats.
['Hou|Quan-Liang|QL|', 'Ge|Meng-Ying|MY|', 'Zhang|Cheng-da|CD|', 'Tian|Dan-Dan|DD|', 'Wang|Lian-Ke|LK|', 'Tian|Hui-Zi|HZ|', 'Wang|Wen-Hua|WH|', 'Zhang|Wei-Dong|WD|']
D000273:Adipose Tissue D000818:Animals D062186:Arterial Pressure D003094:Collagen D006152:Cyclic GMP D007172:Erectile Dysfunction D008297:Male D009130:Muscle, Smooth D052248:Nitric Oxide Synthase Type I D010410:Penile Erection D051381:Rats D033581:Stem Cell Transplantation
Adipose tissue-derived stem cell Erectile dysfunction Meta-analysis