Effect of ethylcellulose and propylene glycol on the controlled-release performance of glyceryl monooleate-mertronidazole periodontal gel.
Controlled-release metronidazole, mucoadhesive gel proposed as a drug-delivery system for periodontal application was developed and characterized. The system was based on a mixture of glycerylmonooleate (GMO) and ethylcellulose (EC). The mechanism of release depends: firstly, on the ability of GMO to form a viscous liquid crystalline mesophases and secondly on the solubilized EC to form a hydrophobic network when the mixture comes into contact with water resulting in sustaining the release of the drug. Ethylcellulose dissolved in GMO had a profound influence on the rate of drug release, reduced the initial drug release and prolonged the sustained release of metronidazole. Propylene glycol (PG) was added to increase the solubility of the drug and water was added with PG to control the viscosity. A controlled release formulation containing w/w, 20% metronidazole, 10% PG, 5% water and 65% GMO that contains 7% EC was found to be mucoadhesive, easily injectable at room temperature, and to follow Fickian diffusion release mechanism. When the drug loading was increased the drug release was accelerated, and the mechanism followed anomalous controlled-release mechanism. Stability studies indicated that the formulation should be stored at 4 °C in a dark place.
['Sallam|Al-Sayed|AS|', 'Hamudi|Firas Falih|FF|', 'Khalil|Enam Ayoub|EA|']
D000268:Adhesiveness D000818:Animals D000890:Anti-Infective Agents D002482:Cellulose D002645:Chickens D003692:Delayed-Action Preparations D016503:Drug Delivery Systems D065546:Drug Liberation D004355:Drug Stability D004356:Drug Storage D005079:Excipients D005782:Gels D005989:Glycerides D006801:Humans D008795:Metronidazole D009092:Mucous Membrane D010316:Particle Size D010510:Periodontal Diseases D044367:Phase Transition D019946:Propylene Glycol D012212:Rheology D012995:Solubility
periodontal mucoadhesive Liquid crystals metronidazole gel pharmaceutical gel