The association between the adrenergic hyperactivity and blood pressure values in people with multiple sclerosis.
OBJECTIVES
To evaluate the evolution of adrenergic baroreflex sensitivity (BRSa) over 2-year follow-up and to investigate the effect of baseline BRSa indices on blood pressure values after 2 years in people with multiple sclerosis (pwMS).


METHODS
The following data were analysed at baseline and after 2 years: BRSa measured with BRSa1, α-BRSa and β-BRSa, supine and tilted levels of epinephrine and norepinephrine, supine and tilted systolic and diastolic blood pressure levels.


RESULTS
Compared to baseline values, there was no change in α-BRSa (6.96 ± 2.56 vs. 6.64 ± 2.24, p = 0.379) at month 24. α-BRSa at month 24 positively correlated with tilted levels of norepinephrine at month 24 (rp = 0.357, p = 0.005). Univariable linear regression analysis revealed that α-BRSa at baseline predicts the value of tilted systolic and diastolic blood pressure at month 24 (B = 2.724, 95% CI 1.357-4.091, p < 0.001 and B = 1.489, 95% CI 0.459-2.519, p = 0.005).


CONCLUSION
This study provides further evidence for possible role of α-BRSa as a marker of adrenergic hyperactivity in pwMS. These results may explain increased risk for cardiovascular diseases in pwMS.
['Habek|Mario|M|', 'Pucić|Dunja|D|', 'Mutak|Tomislav|T|', 'Crnošija|Luka|L|', 'Lovrić|Mila|M|', 'Krbot Skorić|Magdalena|M|']
D018663:Adrenergic Agents D017704:Baroreflex D001794:Blood Pressure D002318:Cardiovascular Diseases D006339:Heart Rate D006801:Humans D006973:Hypertension D009103:Multiple Sclerosis
Adrenergic hyperactivity Multiple sclerosis Arterial hypertension Autonomic nervous system Comorbidities