miR-20a promotes prostate cancer invasion and migration through targeting ABL2.
The aberrant expression of microRNAs (miRNAs) has been found in various types of cancer. The present study found miR-20a was significantly up-regulated in prostate cancer compared with normal prostate tissues. Patients with a higher miR-20a expression had a Gleason score of 7-10 and shorter survival time. The transwell and wound healing assays revealed that blocking expression of miR-20a by miR-20a ASO suppresses the invasion and migration of PC-3 and DU145 cells in vitro and also inhibits tumor growth in vivo. Furthermore, we identified miR-20a directly targets the ABL family non-receptor tyrosine kinases ABL2 and negatively regulates the phosphorylation of its downstream gene p190RhoGAP. Knockdown of ABL2 promoted cell invasion and migration and we identified miR-20a-induced cell invasion and migration can be rescued by ABL2. In conclusion, our findings show that miR-20a significantly contributes to the progression of prostate cancer by targeting ABL2.
['Qiang|Xiao-Fei|XF|', 'Zhang|Zheng-Wei|ZW|', 'Liu|Qian|Q|', 'Sun|Nan|N|', 'Pan|Liang-Liang|LL|', 'Shen|Jing|J|', 'Li|Tong|T|', 'Yun|Chen|C|', 'Li|Hui|H|', 'Shi|Li-Hua|LH|']
D020413:3' Untranslated Regions D045744:Cell Line, Tumor D002465:Cell Movement D049109:Cell Proliferation D020690:GTPase-Activating Proteins D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008297:Male D035683:MicroRNAs D060787:Neoplasm Grading D009361:Neoplasm Invasiveness D010766:Phosphorylation D011467:Prostate D011471:Prostatic Neoplasms D011505:Protein-Tyrosine Kinases D016315:Proto-Oncogene Proteins c-abl D034622:RNA Interference D012333:RNA, Messenger D034741:RNA, Small Interfering D015854:Up-Regulation
miR-20a PROSTATE CANCER INVASION MIGRATION ABL2 p190RhoGAP