Diabetes mellitus with normal renal function is associated with anaemia.
BACKGROUND
Anaemia is a common complication of diabetes mellitus (DM), usually related to renal failure. There is scarce information as to the levels of haemoglobin (Hb) and the rate of anaemia in diabetic patients with normal renal function. We, therefore, evaluated haemoglobin levels and the rate of anaemia in diabetic subjects with normal renal functions [estimated glomerular filtration rate (eGFR) > 60 mL/min].


METHODS
The charts of 9250 subjects who attended the Institute of Periodic Medical Examinations at the Chaim Sheba Medical Center for a routine yearly check-up were reviewed. Four hundred and forty-five subjects with type 2 DM and normal renal function were indentified and compared with those without DM who were routinely examined at the same time. Subjects' electronic records were used to build a biochemical and clinical database.


RESULTS
Mean haemoglobin levels were lower in subjects with DM than in those without (14.2 vs. 14.7 g/dL, respectively; p < 0.001). Anaemia was observed in 48 (10.8%) subjects in the diabetic group and in only 12 (2.7%) in the nondiabetic group (p < 0.001). Multivariate analysis revealed that age, gender, history of gastrointestinal disease, use of beta blockers, renal function and DM were independent determinants of haemoglobin levels. After adjustment for age, gender, history of gastrointestinal tract diseases and renal function, DM remained a significant determinant of anaemia with an odds ratio of 2.15 (confidence interval: 1.07-4.31).


CONCLUSIONS
Anaemia is more common in diabetic patients even when eGFR > 60 mL/min.
['Grossman|Chagai|C|', 'Dovrish|Zamir|Z|', 'Koren-Morag|Nira|N|', 'Bornstein|Gil|G|', 'Leibowitz|Avshalom|A|']
D000368:Aged D000740:Anemia D000959:Antihypertensive Agents D003924:Diabetes Mellitus, Type 2 D003928:Diabetic Nephropathies D057286:Electronic Health Records D005260:Female D005919:Glomerular Filtration Rate D006410:Hematopoiesis D006454:Hemoglobins D006801:Humans D007004:Hypoglycemic Agents D007557:Israel D007668:Kidney D008297:Male D008875:Middle Aged D015995:Prevalence D051437:Renal Insufficiency D012307:Risk Factors D012737:Sex Factors
diabetes mellitus renal functions anaemia haemoglobin