Risk of severe illness of COVID-19 patients with NAFLD and increased NAFLD fibrosis scores.
BACKGROUND
There is still little knowledge about the association of liver fibrosis with the clinical outcomes of COVID-19 patients with non-alcoholic fatty liver disease (NAFLD). The aim of the study was to determine the association of NAFLD fibrosis score (NFS)-determined liver fibrosis with clinical outcomes of COVID-19 patients with NAFLD.


METHODS
The NAFLD was diagnosed by the Hepatic Steatosis Index (HSI) in the absence of other causes of chronic liver diseases. NFS was used to evaluate the severity of liver fibrosis.


RESULTS
A total of 86 COVID-19 patients with NAFLD were included. The median age was 43.5 years, and 58.1% of patients were male. Thirty-eight (44.2%) patients had advanced liver fibrosis according to the NFS. Multivariate analysis indicated that concurrent diabetes (odds ratio [OR] 8.264, 95% confidence interval [CI] 1.202-56.830, p = 0.032) and advanced liver fibrosis (OR 11.057, 95% CI 1.193-102.439, p = 0.034) were independent risk factors of severe illness in COVID-19 patients with NAFLD.


CONCLUSION
NAFLD patients with NFS-determined advanced liver fibrosis are at higher risk of severe COVID-19.
['Yao|Renling|R|', 'Zhu|Li|L|', 'Wang|Jian|J|https://orcid.org/0000-0001-5004-0877', 'Liu|Jiacheng|J|', 'Xue|Ruifei|R|', 'Xue|Leyang|L|', 'Liu|Longgen|L|', 'Li|Chunyang|C|', 'Zhao|Haiyan|H|', 'Cheng|Juan|J|', 'Huang|Songping|S|', 'Li|Yang|Y|', 'Zhao|Xiang-An|XA|', 'Zhu|Chuanwu|C|', 'Li|Ming|M|', 'Huang|Rui|R|', 'Wu|Chao|C|https://orcid.org/0000-0002-1657-010X']
D000328:Adult D000086382:COVID-19 D005260:Female D006760:Hospitalization D006801:Humans D008103:Liver Cirrhosis D016015:Logistic Models D008297:Male D008875:Middle Aged D065626:Non-alcoholic Fatty Liver Disease D012189:Retrospective Studies D012307:Risk Factors D012720:Severity of Illness Index
severe illness COVID-19 fibrosis non-alcoholic fatty liver disease