Facile synthesis of Silicon quantum dot-Gadolinium: A potential fluorescent/T1-T2 multimodal imaging agent.
Highly stable and multifunctional fluorescent quantum dots are particularly attractive in practical applications. Here, a new kind of ultra-small-sized silicon quantum dot-gadolinium (SiQD-Gd) was successfully fabricated by a newly-designed facile hydrothermal growth and chelating method. The obtained SiQD-Gd exhibited outstanding water dispersibility, stability and good fluorescent property with the quantum yield of 11.6%. SiQD-Gd displayed a low cytotoxicity in normal cell lines (HELF, HEK293F) and tumor cell lines (H1299, A549). Meanwhile, SiQD-Gd showed excellent magnetic resonance response with r1 relaxation rate of 10.5 mmol L-1·s-1 and r2 relaxation rate of 47.5 mmol L-1·s-1, which are 2.5 and 7.4 times enhanced comparing to that of the commercial MR agent Magnevist. In vivo studies showed significant contrast enhancement effect of its T1- and T2-weighted MR imaging. In addition, in vivo fluorescent imaging for mice and zebrafish indicated its potential applications in fluorescent tracking. Thus, the excellent multimodal imaging capacity and biocompatibility of SiQD-Gd make it a potential imaging agent for clinic applications.
['Xiao|Fangnan|F|', 'Xiao|Yue|Y|', 'Chen|Fangman|F|', 'Liu|Xiaolin|X|', 'Lin|Chentao|C|', 'Chen|Jianxin|J|', 'Wu|Yunkun|Y|']
D000818:Animals D002460:Cell Line D005456:Fluorescent Dyes D005682:Gadolinium D006801:Humans D051379:Mice D064847:Multimodal Imaging D045663:Quantum Dots D012825:Silicon D015027:Zebrafish
Fluorescence Multimodal imaging SiQD-Gd MRI