Nano-carrier based drug delivery systems for sustained antimicrobial agent release from orthopaedic cementous material.
Total joint replacement (TJR), such as hip and knee replacement, is a popular procedure worldwide. Prosthetic joint infections (PJI) after this procedure have been widely reported, where treatment of such infections is complex with high cost and prolonged hospital stay. In cemented arthroplasties, the use of antibiotic loaded bone cement (ALBC) is a standard practice for the prophylaxis and treatment of PJI. Recently, the development of bacterial resistance by pathogenic microorganisms against most commonly used antibiotics increased the interest in alternative approaches for antimicrobial delivery systems such as nanotechnology. This review summarizes the efforts made to improve the antimicrobial properties of PMMA bone cements using nanotechnology based antibiotic and non-antibiotic delivery systems to overcome drawbacks of ALBC in the prophylaxis and treatment of PJIs after hip and knee replacement.
['Al Thaher|Yazan|Y|', 'Perni|Stefano|S|', 'Prokopovich|Polina|P|']
D000900:Anti-Bacterial Agents D019644:Arthroplasty, Replacement, Hip D019645:Arthroplasty, Replacement, Knee D001843:Bone Cements D003692:Delayed-Action Preparations D004339:Drug Compounding D006801:Humans D057927:Hydrophobic and Hydrophilic Interactions D007595:Joint Prosthesis D036103:Nanotechnology
Antimicrobial TJR PJI Bone cement Nanotechnology PMMA Nanoparticles