Non-dioxin-like Polychlorinated Biphenyls (PCBs) and Chlordecone Release from Adipose Tissue to Blood in Response to Body Fat Mobilization in Ewe (Ovis aries).
Understanding how persistent organic pollutants (POPs) are released from adipose tissue (AT) to blood is a critical step in proposing rearing strategies hastening the removal of POPs from contaminated livestock. The current study aimed to determine in nonlactating ewes whether polychlorinated biphenyls (PCBs) and chlordecone are released from AT to blood along with lipids during body fat mobilization achieved through β-agonist challenges or undernutrition. β-Agonist challenges did not affect serum POP concentrations, whereas serum PCBs 138, 153, and 180 were readily increased in response to undernutrition. After 21 days of depuration in undernutrition, AT PCB 153 and 180 concentrations were increased concomitantly with a decrease in adipocyte volume, whereas AT chlordecone concentration was not different from that observed at the end of the well-fed contamination period. Thus, undernutrition may be of practical relevance for accelerating POP depuration unless it is combined with a strategy increasing their excretion pool.
['Lerch|Sylvain|S|', 'Guidou|Côme|C|', 'Thomé|Jean-Pierre|JP|', 'Jurjanz|Stefan|S|']
D000273:Adipose Tissue D000818:Animals D007631:Chlordecone D004785:Environmental Pollutants D005223:Fats D011078:Polychlorinated Biphenyls D012756:Sheep
non-dioxin-like polychlorinated biphenyls chlordecone body fat mobilization ewe β-agonist undernutrition