Effects of perampanel add-on therapy on immunoglobulin levels in pediatric patients with epilepsy.
BACKGROUND
Perampanel (PER) has a unique pharmacological mechanism and marked efficacy in both focal and generalized epilepsy, but may cause adverse events similar to those of other antiepileptic drugs (AEDs). AEDs can affect multiple organ systems, as well as thyroid function, lipid profiles, and immunoglobulin levels; the low free T4 levels, hyperlipidemia, and low immunoglobulin levels can be caused by AEDs. While many studies have examined conventional AEDs, little is known about the long-term effects of PER on blood parameters.


METHODS
We retrospectively reviewed the medical records of 18 pediatric patients with epilepsy who were treated with PER added to >1 other AED. Blood parameters (e.g., blood cell counts, biochemical and thyroid function, and immunoglobulin levels) were investigated at baseline and at 6 and 12 months after initiation of PER.


RESULTS
PER did not affect the blood counts, transaminase levels, lipid profile, or thyroid function at 12 months after initiation of PER. However, IgA levels significantly increased (p = 0.00319) without symptoms. IgM levels increased temporarily, but had returned to baseline by 12 months after initiation of PER.


CONCLUSIONS
IgA levels were elevated at 12 months after initiation of PER in pediatric patients with intractable epilepsy, although no symptoms were observed. PER did not affect other parameters, including lipid profile and thyroid function.
['Ishikawa|Nobutsune|N|', 'Tateishi|Yuichi|Y|', 'Tani|Hiroo|H|', 'Kobayashi|Yoshiyuki|Y|', 'Okada|Satoshi|S|']
D000293:Adolescent D000927:Anticonvulsants D002648:Child D000069279:Drug Resistant Epilepsy D004359:Drug Therapy, Combination D004827:Epilepsy D004829:Epilepsy, Generalized D005260:Female D006801:Humans D008297:Male D009570:Nitriles D011728:Pyridones
Perampanel immunoglobulin long-term blood parameters IgA children