Advanced native-kidney carcinoma in a heart- and kidney-transplanted patient: a case report.
Malignancies are one of the leading causes of death in long-term surviving transplant recipients. Dose and prolonged durations of immunosuppressive regimens are considered the main cause, through a direct oncogenic effect and a renowned interaction on physiological anti-viral and anti-oncogenic immune response. Specific neoplasms are known to occur with different frequencies according to the transplanted organ. As a consequence, imaging screenings have been implemented in many graft surveillance programs, although a wide consensus on the timing and modality has not been concurred. There are little data available in the literature regarding incidence of de-novo malignancies in multi-organ recipients. We report the case of a 66-year-old man who developed a renal mass 10 years after a combined heart-kidney transplant.
['Paoletti|Matteo|M|http://orcid.org/0000-0002-1221-7747', 'Cattadori|Barbara|B|', 'Gregorini|Marilena|M|', 'Viglio|Alessandra|A|', 'Gentile|Giovanni|G|', "D'Armini|Andrea Maria|AM|", 'Pellegrini|Carlo|C|', 'La Fianza|Alfredo|A|']
Immunosuppression Cancer screening Heart transplantation Kidney transplantation Post-transplant malignancy