Comprehensive analysis of polymorphisms in the HLA-G 5' upstream regulatory and 3' untranslated regions in Brazilian patients with systemic lupus erythematosus.
This study aims to comprehensively analyze human leucocyte antigen (HLA)-G polymorphisms association with susceptibility to systemic lupus erythematosus (SLE) development and clinical manifestations. The HLA-G 5' upstream regulatory region (URR), 3' untranslated region (UTR) and a cytosine deletion at exon 3 (ΔC, HLA-G*0105N allele) were analyzed in 114 SLE patients and 128 healthy controls from North East Brazil. The +3003T>C (rs1707) C allele and the HG010101c extended HLA-G allele were significantly more frequent in SLE patients than healthy controls (+3003C allele frequency: 12% in SLE patients vs 6% in controls; odds ratio (OR), 2.10, 95% confidence interval (CI), 1.06-4.28, P = 0.026; HG010101c frequency: 11.8% in SLE patients and 6.3% in controls; OR, 2.14, 95% CI, 1.01-4.51, P = 0.046) and were associated with susceptibility for disease development. Other polymorphisms were associated with different clinical manifestations. Although HLA-G role in SLE disease is far from being elucidated yet, our association study results along with a systematic review and meta-analysis suggest that HLA-G might be able to slightly modulate the complex SLE phenotype (pooled OR, 1.14, 95% CI, 1.02-1.27, P = 0.021).
['Catamo|E|E|', 'Addobbati|C|C|', 'Segat|L|L|', 'Sotero Fragoso|T|T|', 'Tavares Dantas|A|A|', 'de Ataide Mariz|H|H|', 'Ferreira da Rocha Junior|L|L|', 'Branco PintoDuarte|A L|AL|', 'Coelho|A V C|AV|', 'de Moura|R R|RR|', 'Polesello|V|V|', 'Crovella|S|S|', 'Sandrin Garcia|P|P|']
D020413:3' Untranslated Regions D020121:5' Untranslated Regions D000328:Adult D000483:Alleles D001323:Autoantibodies D001938:Brazil D005260:Female D005787:Gene Frequency D020022:Genetic Predisposition to Disease D059951:HLA-G Antigens D006239:Haplotypes D006801:Humans D054643:INDEL Mutation D008180:Lupus Erythematosus, Systemic D008297:Male D008875:Middle Aged D020641:Polymorphism, Single Nucleotide D063189:Symptom Assessment
polymorphisms systemic lupus erythematosus human leukocyte antigen-G mRNA stability