MMP-1 promoter polymorphism is associated with risk of radiation-induced lung injury in lung cancer patients treated with radiotherapy.
Matrix metalloproteinase-1 (MMP-1) has been implicated in several inflammatory and fibrotic diseases. We hypothesized that genetic variations in the MMP1 promoter region are associated with risk of radiation-induced lung injury (RILI). A cohort of 251 lung cancer patients was genotyped for five single nucleotide polymorphisms in the MMP1 promoter region. We found that rs1144393 AG/GG was strongly correlated with an increased occurrence of grade ≥ 2 RILI (p = 0.002). Additionally, patients with the rs1144393 AG/GG genotypes exhibited higher MMP-1 expression than patients with the AA genotype in lung tissues (n = 28, p = 0.022) and plasma samples (n = 40, p = 0.018). Our results indicated that rs1144393 in the MMP1 promoter region can be a predictor of grade ≥ 2 RILI in lung cancer patients treated with thoracic radiation.
['Liu|Bo|B|', 'Yi|Minxiao|M|', 'Tang|Yang|Y|', 'Liu|Qingxu|Q|', 'Qiu|Hong|H|', 'Zou|Yanmei|Y|', 'Peng|Ping|P|', 'Zhang|Lu|L|', 'Hu|Chunping|C|', 'Yuan|Xianglin|X|']
D000328:Adult D000368:Aged D005260:Female D005838:Genotype D006801:Humans D055370:Lung Injury D008175:Lung Neoplasms D008297:Male D020781:Matrix Metalloproteinase 1 D008875:Middle Aged D020641:Polymorphism, Single Nucleotide D011832:Radiation Injuries
MMP-1 radiation-induced lung injury lung cancer radiotherapy single nucleotide polymorphism