Network structure shapes spontaneous functional connectivity dynamics.
The structural organization of the brain constrains the range of interactions between different regions and shapes ongoing information processing. Therefore, it is expected that large-scale dynamic functional connectivity (FC) patterns, a surrogate measure of coordination between brain regions, will be closely tied to the fiber pathways that form the underlying structural network. Here, we empirically examined the influence of network structure on FC dynamics by comparing resting-state FC (rsFC) obtained using BOLD-fMRI in macaques (Macaca fascicularis) to structural connectivity derived from macaque axonal tract tracing studies. Consistent with predictions from simulation studies, the correspondence between rsFC and structural connectivity increased as the sample duration increased. Regions with reciprocal structural connections showed the most stable rsFC across time. The data suggest that the transient nature of FC is in part dependent on direct underlying structural connections, but also that dynamic coordination can occur via polysynaptic pathways. Temporal stability was found to be dependent on structural topology, with functional connections within the rich-club core exhibiting the greatest stability over time. We discuss these findings in light of highly variable functional hubs. The results further elucidate how large-scale dynamic functional coordination exists within a fixed structural architecture.
['Shen|Kelly|K|', 'Hutchison|R Matthew|RM|', 'Bezgin|Gleb|G|', 'Everling|Stefan|S|', 'McIntosh|Anthony R|AR|']
D000818:Animals D001921:Brain D001931:Brain Mapping D005260:Female D007091:Image Processing, Computer-Assisted D008252:Macaca fascicularis D008279:Magnetic Resonance Imaging D008297:Male D008959:Models, Neurological D009434:Neural Pathways D017711:Nonlinear Dynamics D010100:Oxygen
functional connectivity large-scale dynamics structural connectivity functional MRI rich club organization