Barrett's esophagus is negatively associated with eosinophilic esophagitis in Japanese subjects.
BACKGROUND
Although both eosinophilic esophagitis (EoE) and Barrett's esophagus (BE) are considered to be associated with T helper (Th) 2-mediated immune responses, the association between EoE and BE is unclear. We investigated the clinical relationship between EoE and BE.


METHODS
We conducted a single-center retrospective observational study. The study included 95 patients with EoE and randomly selected age- and sex-matched controls who underwent esophagogastroduodenoscopy during a medical health check-up at Osaka City University in a ratio of 1:2 for comparison. We compared the clinical characteristics and the prevalence rate of BE, reflux esophagitis (RE), hiatal hernia, and atrophic gastritis between EoE patients and controls by univariate analysis. Furthermore, we performed multivariate logistic regression analysis to investigate the association of these factors with EoE.


RESULTS
On univariate analysis, the prevalence rate of BE was significantly lower in patients with EoE than in controls (2.1% vs. 13.2%; p = 0.00528). In contrast, the prevalence rate of RE was higher in EoE patients than in controls, but it was not statistically significant (absence and Grades A, B, and C: 74.7%, 18.9%, 5.3%, and 1.1% vs. 83.7%, 12.6%, 3.7%, and 0%; p = 0.193, respectively). Multivariate analysis showed that BE was negatively associated with EoE (odds ratio: 0.132; 95% confidence interval: 0.0302-0.573; p = 0.00686).


CONCLUSIONS
BE is negatively associated with EoE in Japanese subjects. The mechanism behind the inverse relationship between EoE and BE should be examined.
['Takashima|Shingo|S|', 'Tanaka|Fumio|F|http://orcid.org/0000-0002-9186-1249', 'Otani|Koji|K|', 'Hosomi|Shuhei|S|', 'Nagami|Yasuaki|Y|', 'Kamata|Noriko|N|', 'Taira|Koichi|K|', 'Yamagami|Hirokazu|H|', 'Tanigawa|Tetsuya|T|', 'Fukumoto|Shinya|S|', 'Watanabe|Toshio|T|', 'Fujiwara|Yasuhiro|Y|']
D001471:Barrett Esophagus D016022:Case-Control Studies D057765:Eosinophilic Esophagitis D004942:Esophagitis, Peptic D005260:Female D006801:Humans D007564:Japan D008297:Male D008875:Middle Aged D012189:Retrospective Studies
Esophagus Eosinophilic esophagitis Eosinophils Barrett’s esophagus Peptic esophagitis