LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression.
Postpartum depression (PPD) is a kind of mental disorder characterized by persistent low emotions in puerperium. The most significant physiological change in postpartum is lactation which is regulated by oxytocin receptor (OXTR). However, whether OXTR is related to pathological process of PPD and the potential mechanism still remain unclear. In the present study, we prepared hormone-simulated pregnancy (HSP)-induced PPD mouse model and found that the protein level of OXTR in hippocampus of PPD model mice was down-regulated and Nod-like receptor protein 3 (NLRP3) inflammasome was activated. We identified five long non-coding RNAs (lncRNAs) related to PPD by transcriptome sequencing, including three up-regulated and two down-regulated. The five lncRNAs were associated with the signaling pathway of OXTR according to the bioinformatics analysis. Furthermore, we focused on one of the five lncRNAs, Gm14205, and found that it targeted OXTR which inhibited astrocytic NLRP3 inflammasome activation in hippocampal primary astrocytes. These findings illustrate that OXTR has protective effects in PPD by inhibiting NLRP3 inflammasome activation and provides a new strategy for targeting lncRNA Gm14205 in the pathogenesis of PPD.
['Zhu|Jialei|J|', 'Tang|Jing|J|']
D000818:Animals D001253:Astrocytes D001522:Behavior, Animal D019052:Depression, Postpartum D004195:Disease Models, Animal D005260:Female D005518:Food Preferences D005786:Gene Expression Regulation D006624:Hippocampus D058847:Inflammasomes D008810:Mice, Inbred C57BL D009043:Motor Activity D000071199:NLR Family, Pyrin Domain-Containing 3 Protein D011247:Pregnancy D062085:RNA, Long Noncoding D018045:Receptors, Oxytocin D015398:Signal Transduction D059467:Transcriptome
Astrocyte NLRP3 inflammasome Oxytocin receptor Postpartum depression Long non-coding RNA