Is Ki-67 of Diagnostic Value in Distinguishing Between Partial and Complete Hydatidiform Moles? A Systematic Review and Meta-analysis.
BACKGROUND/AIM
To demonstrate the value of Ki-67 in distinguishing between partial and complete hydatidiform moles.


MATERIALS AND METHODS
We searched electronic databases included Medline, WOK, Cochrane Library and CNKI, through January 24, 2015. Experts were consulted, and references from related articles were examined. The meta-analysis was conducted with RevMan5.3, according to the PRISMA guidelines. Mantel-Haenszel estimates were calculated and pooled under a random effect model, with data expressed as odds ratio (OR) and 95% confidence interval (CI).


RESULTS
We analyzed eight trials with a total of 337 participants who underwent uterine curettage and met the inclusion criteria. A significantly higher expression of Ki-67 was observed in complete than in partial hydatidiform moles (OR=3.28; 95%CI=1.80-5.96; p<0.0001).


CONCLUSION
The Ki-67 expression was higher in complete than in partial hydatidiform moles. Therefore, Ki-67 may be of diagnostic value in distinguishing between partial and complete hydatidiform moles. However, the present study had only a limited number of samples, so investigation of a greater number of cases is needed to confirm this conclusion.
['Zhao|Yue|Y|', 'Xiong|Guang-Wu|GW|', 'Zhang|Xiao-Wei|XW|', 'Hang|B O|BO|']
D014408:Biomarkers, Tumor D005260:Female D006801:Humans D006828:Hydatidiform Mole D019394:Ki-67 Antigen D011247:Pregnancy D011379:Prognosis D014594:Uterine Neoplasms
hydatidiform mole meta-analysis Diagnosis Ki-67 antigen