Proteomic Analysis of the Hippocampus in Mouse Models of Trigeminal Neuralgia and Inescapable Shock-Induced Depression.
To investigate the behavioral and biomolecular similarity between neuralgia and depression, a trigeminal neuralgia (TN) mouse model was established by constriction of the infraorbital nerve (CION) to mimic clinical trigeminal neuropathic pain. A mouse learned helplessness (LH) model was developed to investigate inescapable foot-shock-induced psychiatric disorders like depression in humans. Mass spectrometry was used to assess changes in the biomolecules and signaling pathways in the hippocampus from TN or LH mice. TN mice developed not only significant mechanical allodynia but also depressive-like behaviors (mainly behavioral despair) at 2 weeks after CION, similar to LH mice. MS analysis demonstrated common and distinctive protein changes in the hippocampus between groups. Many protein function families (such as cell-to-cell signaling and interaction, and cell assembly and organization,) and signaling pathways (e.g., the Huntington's disease pathway) were involved in chronic neuralgia and depression. Together, these results demonstrated that the LH and TN models both develop depressive-like behaviors, and revealed the involvement of many psychiatric disorder-related biomolecules/pathways in the pathogenesis of TN and LH.
['Guo|Qing-Huan|QH|', 'Tong|Qing-He|QH|', 'Lu|Ning|N|', 'Cao|Hong|H|', 'Yang|Liu|L|', 'Zhang|Yu-Qiu|YQ|']
D000818:Animals D001362:Avoidance Learning D019208:Brain-Derived Neurotrophic Factor D003863:Depression D004195:Disease Models, Animal D004597:Electroshock D007839:Functional Laterality D006380:Helplessness, Learned D019417:Hindlimb Suspension D006624:Hippocampus D008297:Male D013058:Mass Spectrometry D051379:Mice D008810:Mice, Inbred C57BL D009915:Orbit D010147:Pain Measurement D040901:Proteomics D011930:Reaction Time D015398:Signal Transduction D014277:Trigeminal Neuralgia
Trigeminal neuralgia Depression Learned helplessness Mass spectrometry Allodynia