Photo-induced programmable degradation of carboxymethyl chitosan-based hydrogels.
Hydrogels are widely used in the biomedical field, due to their high similarity to native extracellular matrix (ECM). Most responsive hydrogels could only passively receive stimuli and independently change their properties. In this study, a photosensitive o-nitrobenzyl (NB) ester linker of polyethylene glycol (PEG) with maleimido (Mal) as terminal groups (PEG-NB-Mal) and a 5-methylfurfuryl (mF) grafted carboxymethyl chitosan (CMCS) derivative (CMCS-mF) were synthesized and used to prepare functional hydrogels via Diels-Alder (DA) reactions. The hydrogel exhibited programmable degradation properties after sequential exposure to UV light and acid treatments. It can maintain high integrity upon the single stimuli, the cascade acid and UV light treatments or the cascade UV light and alkaline treatments. Moreover, the hydrogel exhibited well controlled release profile of rhodamine B (RB). In summary, such CMCS-based hydrogels show great potential in biomedical applications. In addition, the usage of photo-induced cascade reaction in sequential degradation hydrogels can be extended to design other types of programmable smart materials.
['Wei|Qingcong|Q|', 'Bai|Jiahao|J|', 'Wang|Huan|H|', 'Ma|Guanglei|G|', 'Li|Xinjuan|X|', 'Zhang|Weiwei|W|', 'Hu|Zhiguo|Z|']
D000143:Acids D048271:Chitosan D061565:Cycloaddition Reaction D065546:Drug Liberation D020100:Hydrogels D009682:Magnetic Resonance Spectroscopy D010777:Photochemistry D011092:Polyethylene Glycols D011134:Polysaccharides D012235:Rhodamines D013056:Spectrophotometry, Ultraviolet D017550:Spectroscopy, Fourier Transform Infrared D014466:Ultraviolet Rays
Hydrogel Carboxymethyl chitosan Sequential degradation Photo-responsive