Further Evidence for Hypercoagulability in Women With Ovarian Endometriomas.
Our previous studies have shown that platelets play a crucial role in the development of endometriosis, and women with endometriosis appear to be in a state of hypercoagulability. However, a recent study could only replicate part of our previous finding, casting doubts on this notion. We further investigated this question through a cross-sectional study by measuring additional coagulation factors in women with and without endometriosis. To this end, we conducted a cross-sectional study of 100 women with laparoscopically and pathologically diagnosed ovarian endometriomas (OMA) and another 100 women without endometriosis. The platelet count; platelet activation rate; maximum platelet aggregation rate; plasma levels of D-dimer, fibrinogen, fibrin degradation products (FDPs), plasma soluble P-selectin (sP-sel), and prothrombin fragment 1+2 (F1+2); prothrombin time; thrombin time (TT); and activated partial thromboplastin time were measured before surgery and 3 months after surgery, and their clinical data were recorded. These measurements were also performed in control patients. We found that, compared with controls, women with OMA had a significantly higher platelet activation rate and platelet aggregation rate, elevated plasma D-dimer, fibrinogen, FDPs, sP-sel, and F1+2 levels as well as shortened TT. Remarkably, TT was prolonged, and all the other coagulation measurements, except plasma fibrinogen level, were significantly reduced 3 months after surgical removal of endometriotic lesions. Thus, our study provides another piece of evidence that endometriosis is a hypercoagulable disease, and anticoagulation therapy may hold promises in treating endometriosis.
['Ding|Ding|D|', 'Liu|Xishi|X|', 'Guo|Sun-Wei|SW|']
D000328:Adult D001780:Blood Coagulation Tests D001792:Blood Platelets D003430:Cross-Sectional Studies D004715:Endometriosis D005260:Female D006801:Humans D008875:Middle Aged D010049:Ovarian Diseases D015539:Platelet Activation D010974:Platelet Aggregation D010976:Platelet Count D019851:Thrombophilia D055815:Young Adult
hypercoagulability platelet endometriosis coagulation fibrin degradation product prothrombin fragments