Novel Triazole linked 2-phenyl benzoxazole derivatives induce apoptosis by inhibiting miR-2, miR-13 and miR-14 function in Drosophila melanogaster.
Apoptosis is an important phenomenon in multi cellular organisms for maintaining tissue homeostasis and embryonic development. Defect in apoptosis leads to a number of disorders like- autoimmune disorder, immunodeficiency and cancer. 21-22 nucleotides containing micro RNAs (miRNAs/miRs) function as a crucial regulator of apoptosis alike other cellular pathways. Recently, small molecules have been identified as a potent inducer of apoptosis. In this study, we have identified novel Triazole linked 2-phenyl benzoxazole derivatives (13j and 13h) as a negative regulator of apoptosis inhibiting micro RNAs (miR-2, miR-13 and miR-14) in a well established in vivo model Drosophila melanogaster where the process of apoptosis is very similar to human apoptosis. These compounds inhibit miR-2, miR-13 and miR-14 activity at their target sites, which induce an increased caspase activity, and in turn influence the caspase dependent apoptotic pathway. These two compounds also increase the mitochondrial reactive oxygen species (ROS) level to trigger apoptotic cell death.
['Mondal|Tanmoy|T|', 'Lavanya|A V S|AVS|', 'Mallick|Akash|A|', 'Dadmala|Tulshiram L|TL|', 'Kumbhare|Ravindra M|RM|', 'Bhadra|Utpal|U|', 'Bhadra|Manika Pal|MP|']
D000818:Animals D017209:Apoptosis D001583:Benzoxazoles D020169:Caspases D002460:Cell Line D004331:Drosophila melanogaster D035683:MicroRNAs D008928:Mitochondria D008954:Models, Biological D038081:Organogenesis D017382:Reactive Oxygen Species D014230:Triazoles D014921:Wings, Animal
Apoptosis Cancer Small molecule Micro RNA inhibitor