A cost-effectiveness analysis of DIEP vs free MS-TRAM flap for microsurgical breast reconstruction.
BACKGROUND AND OBJECTIVES
The deep inferior epigastric perforator (DIEP) flap may be associated with less long-term donor-site morbidity compared with free muscle-sparing transverse rectus abdominis myocutaneous flap (MS-TRAM) flap. However, DIEP flaps may have longer operative time and higher rates of acute postoperative complications. We performed a cost-effectiveness analysis (CEA) that compared the long-term costs and patient-reported outcomes between the two flaps.


METHODS
A retrospective cohort of women who received free MS-TRAM or DIEP flap reconstruction between January 2008 and December 2012, with a minimum of 2-year follow-up, were recruited. Cost data of the primary reconstruction and any subsequent hospitalization due to complications from the reconstruction within 2 years were obtained. Each patient received a BREAST-Q questionnaire at 2 years post-reconstruction.


RESULTS
In total, 227 patients (180 DIEP, 47 free MS-TRAM) were included. DIEP patients had significantly fewer abdominal hernia (P = 0.04). The adjusted-incremental cost-effectiveness ratios found that DIEP flap was more cost-effective to free MS-TRAM flap in the domains of "Physical Well-Being of the Abdomen" and "Satisfaction with Outcome."


CONCLUSIONS
DIEP flap is the more cost-effective method of autologous breast reconstruction in the long-term compared with free MS-TRAM flap with respect to patient-reported abdominal well-being and overall satisfaction with the outcome.
['Tan|Marcus G|MG|http://orcid.org/0000-0001-5718-7783', 'Isaranuwatchai|Wanrudee|W|http://orcid.org/0000-0002-8368-6065', 'DeLyzer|Tanya|T|', 'Butler|Kate|K|', 'Hofer|Stefan O P|SOP|http://orcid.org/0000-0002-9653-2946', "O'Neill|Anne C|AC|http://orcid.org/0000-0002-8036-2866", 'Zhong|Toni|T|']
D001943:Breast Neoplasms D003362:Cost-Benefit Analysis D019074:Epigastric Arteries D005260:Female D005500:Follow-Up Studies D058752:Free Tissue Flaps D006801:Humans D016462:Mammaplasty D008875:Middle Aged D061525:Perforator Flap D011183:Postoperative Complications D011379:Prognosis D017568:Rectus Abdominis D012189:Retrospective Studies
free muscle-sparing transverse rectus abdominis myocutaneous flap autologous breast reconstruction deep inferior epigastric perforator flap patient-reported outcome measures retrospective studies