Bridging the gap between translational medicine and unmet clinical needs.
To date, the actual rate of successful translation has been extremely low although those few successes have been notable and provide for continued and expanding enthusiasm and support. This paper examines whether the fundamental premise may be flawed. Could the success rate be improved to further enhance quality of life and cost optimization for patients by changing the paradigm to "bedside to bench to bedside", and focusing the research on addressing unmet clinical needs? It examines all aspects of the healthcare ecosystem to understand issues that arise with real world patients and in real world clinical practice and how addressing these should be the focus of translational research.
['Liebman|Michael N|MN|', 'Franchini|Michela|M|', 'Molinaro|Sabrina|S|']
D001943:Breast Neoplasms D003695:Delivery of Health Care D017753:Ecosystem D005260:Female D014943:Global Health D017048:Health Care Costs D006301:Health Services Needs and Demand D006801:Humans D008297:Male D019095:Point-of-Care Systems D011787:Quality of Health Care D012131:Respiratory Insufficiency D057170:Translational Research, Biomedical
Translational medicine unmet clinical needs breast cancer rare disease