Role of platelet-rich plasma in healing diabetic foot ulcers: a prospective study.
OBJECTIVE
To evaluate the role of platelet-rich plasma (PRP) in healing diabetic fool ulcers (DFUs), and to compare the rate of healing and final outcome with conventional therapy.


METHOD
A prospective study conducted between October 2013 and July 2015. Participants were divided in to two groups: a study group in which PRP was used and a control group receiving standard therapy. Wound assessment was carried out according to the Bates-Jensen Wound Assessment Tool at 0, 7, 14, 21 and 28 days.


RESULTS
A total of 55 patients were recruited to the study. There were 29 patients in the study group and 26 patients in the control group. After application of PRP, there was significant improvement in mean wound score and significant percent improvement in wound score in the study group (p<0.0001). Complete healing occurred in all patients in the study group in (mean score and standard deviation) 36.7±3 days compared with 60.6±3.7 days in the control group (p<0.0001). There were no unwanted side effects in patients using the PRP in this study.


CONCLUSION
PRP appears to be a promising agent in the management of DFUs. In this study, DFUs healed more quickly in the study group than in the control group. There was also significant percent improvement in wound score as compared with debridement and dressing only. If proper selection criteria are applied, PRP could be a useful aid to wound healing in people with DFUs.
['Singh|Shailendra Pal|SP|', 'Kumar|Vishal|V|', 'Pandey|Anand|A|', 'Pandey|Pinki|P|', 'Gupta|Vipin|V|', 'Verma|Rajesh|R|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D017719:Diabetic Foot D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D053657:Platelet-Rich Plasma D011446:Prospective Studies D013997:Time Factors D016896:Treatment Outcome D014945:Wound Healing
diabetic foot debridement wound healing platelet rich plasma