Diagnosis-specific WBRT-30-CRC Score for Estimating Survival of Patients Irradiated for Brain Metastases from Colorectal Cancer.
BACKGROUND/AIM
Existing survival scores for patients with brain metastases were created in heterogeneously treated cohorts. A new score was developed in 56 patients with brain metastases from colorectal cancer treated with 10×3 Gy of whole-brain radiotherapy (WBRT).


PATIENTS AND METHODS
Factors found significantly associated with survival (p<0.05) or showing a trend (p<0.08) were included in the tool. The new WBRT-30-CRC was compared to diagnosis-specific graded prognostic assessment (DS-GPA) classification for gastrointestinal cancers.


RESULTS
The WBRT-30-CRC included four prognostic groups: 3-4, 5-6, 7-9 and 10 points. Six-month survival rates were 0%, 15%, 38% and 80%. PPV of the 3-4 points-group predicting death ≤6 months was 100% (91% for DS-GPA of 0.0-1.0). PPV of the 10 points-group predicting survival ≥6 months was 80% (0% DS-GPA of 3.5-4.0, 33% DS-GPA of 3.0-4.0).


CONCLUSION
The WBRT-30-CRC appeared very precise in identifying patients with brain metastases from colorectal cancer dying ≤6 months or surviving ≥6 months.
['Rades|Dirk|D|', 'Hansen|Heinke C|HC|', 'Janssen|Stefan|S|', 'Schild|Steven E|SE|']
D000328:Adult D000368:Aged D001932:Brain Neoplasms D015179:Colorectal Neoplasms D016371:Cranial Irradiation D018572:Disease-Free Survival D005260:Female D006801:Humans D053208:Kaplan-Meier Estimate D008297:Male D008875:Middle Aged D009362:Neoplasm Metastasis D011379:Prognosis D016634:Radiosurgery D016896:Treatment Outcome
survival Brain metastases colorectal cancer whole-brain radiotherapy 30 Gy in 10 fractions scoring system