Concomitant sarcoidosis and papillary thyroid cancer with severe hypercalcaemia as the main symptom.
A 65-year-old Caucasian man was admitted to our hospital due to incidental finding of plasma ionised calcium=1.83 mmol/L. During the previous months, he had felt more tired and had experienced an unintended weight loss of 6-8 kg. A CT scan revealed an inhomogeneous thyroid gland and enlarged lymph nodes along the cervical vessels and in the mediastinum. The patient underwent total thyroidectomy and, at the same time, two lymph nodes were removed. Histological examination of the thyroid gland revealed papillary thyroid carcinoma (PTC), T1aN0M0, and histological examination of the lymph nodes showed non-caseating granulomatous inflammation. After further investigation, a diagnosis of sarcoidosis (SA) was made.Coexistence of SA and PTC may yield a diagnostic challenge as both diseases might involve the lymph nodes of the neck. Furthermore, the case illustrates the importance of close follow-up of even moderate hypercalcaemia, since it may evolve into a hypercalcaemic crisis.
['Riis|Mikael Groth|MG|', 'Juhl|Kasper Svendsen|KS|', 'Bruun|Jens Meldgaard|JM|']
D000359:Aftercare D000368:Aged D002291:Carcinoma, Papillary D006099:Granuloma D006801:Humans D006934:Hypercalcemia D033162:Incidental Findings D008198:Lymph Nodes D008297:Male D012507:Sarcoidosis D000077273:Thyroid Cancer, Papillary D013961:Thyroid Gland D013964:Thyroid Neoplasms D013965:Thyroidectomy D014057:Tomography, X-Ray Computed D016896:Treatment Outcome
endocrine cancer immunology thyroid disease