Exercise-Induced Activated Platelets Increase Adult Hippocampal Precursor Proliferation and Promote Neuronal Differentiation.
Physical activity is a strong positive physiological modulator of adult neurogenesis in the hippocampal dentate gyrus. Although the underlying regulatory mechanisms are still unknown, systemic processes must be involved. Here we show that platelets are activated after acute periods of running, and that activated platelets promote neurogenesis, an effect that is likely mediated by platelet factor 4. Ex vivo, the beneficial effects of activated platelets and platelet factor 4 on neural precursor cells were dentate gyrus specific and not observed in the subventricular zone. Moreover, the depletion of circulating platelets in mice abolished the running-induced increase in precursor cell proliferation in the dentate gyrus following exercise. These findings demonstrate that platelets and their released factors can modulate adult neural precursor cells under physiological conditions and provide an intriguing link between running-induced platelet activation and the modulation of neurogenesis after exercise.
['Leiter|Odette|O|', 'Seidemann|Suse|S|', 'Overall|Rupert W|RW|', 'Ramasz|Beáta|B|', 'Rund|Nicole|N|', 'Schallenberg|Sonja|S|', 'Grinenko|Tatyana|T|', 'Wielockx|Ben|B|', 'Kempermann|Gerd|G|', 'Walker|Tara L|TL|']
D000818:Animals D001792:Blood Platelets D049109:Cell Proliferation D018891:Dentate Gyrus D006624:Hippocampus D051379:Mice D058953:Neural Stem Cells D055495:Neurogenesis D009474:Neurons D015539:Platelet Activation D020543:Proteome
platelets neurogenesis dentate gyrus neural precursor cell exercise platelet activation adult mouse