Simultaneous determination of 6-mercaptopruine, 6-thioguanine and dasatinib as three important anticancer drugs using nanostructure voltammetric sensor employing Pt/MWCNTs and 1-butyl-3-methylimidazolium hexafluoro phosphate.
6-Mercaptopurine, 6-thioguanine and dasatinib are three important anticancer drugs with high adverse effects in human body. In this study, a Pt/MWCNTs-1-butyl-3-methylimidazolium hexafluoro phosphate-modified carbon paste electrode was developed for the simultaneously determination of 6-mercaptopurine, 6-thioguanine and dasatinib for the first time. The Pt/MWCNTs synthesized by polyol method and have been characterized by transmission electron microscopy and X-ray diffraction methods. The obtained data revealed that the electro-oxidation of 6-mercaptopurine, 6-thioguanine and dasatinib is facilitated as a novel voltammetric sensor. After optimization of electrochemical parameters employing this sensor at pH 8.0, the oxidation peak currents for 6-mercaptopurine, 6-thioguanine and dasatinib were found to vary linearly with their concentrations in the range of 0.05-550μM; 0.1-500μM and 5.0-500μM with detection limits of 0.009μM, 0.05μM and 1.0μM respectively using square wave voltammetric method. The modified electrode has been applied for the selective and precise analysis of 6-mercaptopurine, 6-thioguanine and dasatinib in pharmaceutical formulations and urine samples.
['Karimi-Maleh|Hassan|H|', 'Shojaei|Abdollah Fallah|AF|', 'Tabatabaeian|Khalil|K|', 'Karimi|Fatemeh|F|', 'Shakeri|Shahryar|S|', 'Moradi|Reza|R|']
D000970:Antineoplastic Agents D045424:Complex Mixtures D003217:Conductometry D000069439:Dasatinib D004867:Equipment Design D019544:Equipment Failure Analysis D006801:Humans D007093:Imidazoles D015122:Mercaptopurine D053768:Metal Nanoparticles D037742:Nanotubes, Carbon D010984:Platinum D015203:Reproducibility of Results D012680:Sensitivity and Specificity D013866:Thioguanine
6-Thioguanine Dasatinib Sensor Pt/MWCNTs 6-Mercaptopurine Ionic liquid