Detection of Chilomastix mesnili in Common Marmoset (Callithrix jacchus) and Treatment with Metronidazole.
Background
Recently, the use of common marmoset (Callithrix jacchus) has increased in biomedical research as an animal model. This study aimed to test fecal samples to monitor bacterial and parasite infections in common marmoset at the Laboratory Animal Center of Osong Medical Innovation Foundation in Korea.


Methods
To monitor bacteria and parasites in common marmoset, we tested 43 fecal samples of 43 common marmosets by culture and parasitological test in 2014. Infection by Chilomastix mesnili was determined by PCR method.


Results
We identified nonpathogenic bacteria such as Proteus mirabilis and Escherichia coli in feces of normal common marmosets. Interestingly, C. mesnili was isolated from a healthy common marmoset by fecal centrifugation concentration and PCR. The monkey infected with C. mesnili was treated with metronidazole. After the treatment, C. mesnili were not found in feces using fecal centrifugation concentration and PCR.


Conclusion
This is the first case report of C. mesnili infection in common marmoset. Treatment with metronidazole is found to be highly effective in eradicating C. mesnili infection in common marmoset.
['Jeong|Eui-Suk|ES|', 'Park|Jong-Hyung|JH|', 'Ryu|Seung-Hyun|SH|', 'Choi|Soo-Young|SY|', 'Lee|Kyoung-Sun|KS|', 'Kim|Jong-Man|JM|', 'Hyun|Byung-Hwa|BH|', 'Choi|Yang-Kyu|YK|']
Chilomastix mesnili Common marmoset Metronidazole Proteus mirabilis Escherichia coli