Olfactory ganglioneuroblastoma in a dog: case report and literature review.
A 7-y-old, intact male Alaskan Malamute was presented with a 3-mo history of stertor and epistaxis. Computed tomography of the skull revealed generalized loss of gas throughout both nasal passages with replacement by a soft tissue mass that traversed the cribriform plate. Histopathology revealed neoplastic neuroblast cells arranged in anastomosing cords, as well as separately located aggregates of ganglion cells. Both neoplastic cell populations demonstrated immunoreactivity to MAP-2, TuJ-1, and synaptophysin. Neuroblastic cells additionally exhibited punctate immunoreactivity to MCK and CK8/18. We document here both the positive neural immunohistochemical markers for this neoplasm, as well as propose possible histomorphologic variants.
['Romano|Ashley M|AM|https://orcid.org/0000-0002-7387-4652', 'Frank|Chad B|CB|']
D000818:Animals D004283:Dog Diseases D004285:Dogs D018305:Ganglioneuroblastoma D008297:Male D009669:Nose Neoplasms D014057:Tomography, X-Ray Computed
olfactory ganglioneuroblastoma dogs computed tomography immunohistochemistry