Corneal Xenotransplantation: Anterior Lamellar Keratoplasty.
Corneal transplantation for the treatment of corneal blindness is challenging in many countries due to the shortage of graft procurement. Xenocorneal transplantation is an interesting alternative to explore despite immunologic rejection, which mainly involves endothelial cells. As anterior lamellar keratoplasty, when indicated, shows less immunologic reaction, we developed and describe below a pig-to-non-human-primate model of anterior lamellar corneal xenograft. This model can be used to assess the efficacy of corneas from genetically modified pigs.
['Vabres|Bertrand|B|', 'Vanhove|Bernard|B|', 'Blancho|Gilles|G|']
D000818:Animals D030801:Animals, Genetically Modified D003316:Corneal Diseases D016039:Corneal Transplantation D006085:Graft Survival D064593:Heterografts D008252:Macaca fascicularis D008297:Male D011182:Postoperative Care D013552:Swine D014183:Transplantation, Heterologous
Xenotransplantation Anterior lamellar keratoplasty Corneal transplantation Pig CTLA4Ig Primate