How diet and the microbiome shape health or contribute to disease: A mini-review of current models and clinical studies.
The studies reviewed in this article combine diet in the context of disease progression or treatment with analysis of the microbiome. First, we present findings on how diet manipulation impacts the microbiome and disease pathogenesis in a broad variety of rodent models of disease. Then, we describe results from clinical trials that are using diet therapies to attempt to shift the microbiome and treat disease symptoms. Finally, we discuss what these studies have taught us about the influence of the microbiome of disease and health states and highlight the evidence suggesting that dietary modulation of the microbiome is an emerging therapeutic option for a variety of different diseases.
['Zangara|Megan T|MT|', 'McDonald|Christine|C|0000-0002-6745-9487']
D000818:Animals D004032:Diet D000069196:Gastrointestinal Microbiome D000076662:Host Microbial Interactions D006801:Humans
Diet microbiome disease genetics immunonutrition inflammation