Dental Anomalies in a Brazilian Cleft Population.
OBJECTIVE
The aim of this study was to radiographically investigate the prevalence of dental anomalies outside the cleft area in a group of Brazilian patients with nonsyndromic cleft lip and/or palate (NSCL/P).


DESIGN, PARTICIPANTS, AND SETTING
A retrospective analysis of 207 panoramic radiographs of patients with NSCL/P aged 12 to 45 years without history of tooth extraction and orthodontic treatment was performed.


RESULTS
Dental anomalies were found in 75.4% of the patients, and tooth agenesis (29.2%) and supernumerary tooth (2.6%) were the most common anomalies. The risk of agenesis was higher among the individuals with cleft palate (CP) compared with individuals with cleft lip (CL) and cleft lip and palate (CLP) (agenesis: CP versus CL: odds ratio 6.27, 95% confidence interval 2.21-17.8, P = .0003; CP versus CLP: odds ratio 2.94; 95% confidence interval 1.27-6.81, P = .01). The frequency of dental agenesis was higher in patients with unilateral complete CLP (agenesis: P < .0001), incomplete bilateral CLP (agenesis: P = .0013), complete CP (agenesis: P < .0001), and incomplete CP (agenesis: P < .0001). The frequency of supernumerary teeth was higher in patients with bilateral complete CLP (P < .0001). The frequency of dental agenesis (P < .0001) and ectopic tooth (P = .009) was higher than the frequency estimated for general population.


CONCLUSIONS
The prevalence of dental anomalies in patients with NSCL/P was higher than that reported in overall population. This study found preferential associations between dental anomalies and specific extensions of NSCL/P, suggesting that dental agenesis and ectopic tooth may be part of oral cleft subphenotypes.
['Sá|Jamile|J|', 'Mariano|Lorena C|LC|', 'Canguçu|Daiane|D|', 'Coutinho|Thaynara S L|TS|', 'Hoshi|Ryuichi|R|', 'Medrado|Alena Peixoto|AP|', 'Martelli-Junior|Hercílio|H|', 'Coletta|Ricardo D|RD|', 'Reis|Silvia R A|SR|']
D000293:Adolescent D000328:Adult D001938:Brazil D002648:Child D002971:Cleft Lip D002972:Cleft Palate D003430:Cross-Sectional Studies D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D012189:Retrospective Studies D014071:Tooth Abnormalities D055815:Young Adult
dental anomaly tooth agenesis cleft lip and palate