Single-nucleotide polymorphism rs10036727 in the SLIT3 gene is associated with osteoporosis at the femoral neck in older Mexican postmenopausal women.
AIMS
Osteoporosis (OP) remains a major public health problem worldwide. The most serious complications of this disease are fragility fractures, which increase morbidity and mortality. Management of OP represents an economic burden for health systems. Therefore, it is necessary to develop new screening strategies to identify the population at risk and implement preventive measures. We previously identified the SNPs rs3801387 in WNT16, rs7108738 in SOX6, rs10036727 in SLIT3 and rs7584262 in PKDCC as associated with bone mineral density in postmenopausal women through a genome-wide association study. The aim of this study was to validate those SNPs in two independent cohorts of non-related postmenopausal women.


MATERIALS AND METHODS
We included 1160 women classifying them as normal, osteopenic or osteoporotic and a group with hip fragility fracture. Genotyping was performed using predesigned TaqMan assays.


RESULTS
The variants rs10036727 and rs7108738 showed a significant association with BMD at the femoral neck. SLIT3 has been previously proposed as a potential biomarker and therapeutic resource.


CONCLUSIONS
Our results provide new evidence regarding a possible involvement of SLIT3 in bone metabolisms and encourage the development of more studies in different populations to support these observations.
['Hidalgo-Bravo|Alberto|A|https://orcid.org/0000-0003-2506-8784', 'Hernández-Medrano|Cristina|C|', 'Sevilla-Montoya|Rosalba|R|https://orcid.org/0000-0002-5658-4661', 'Rivera-Paredez|Berenice|B|https://orcid.org/0000-0002-9845-024X', 'Ramirez-Salazar|Eric Gustavo|EG|https://orcid.org/0000-0002-0767-9357', 'Flores-Morales|Jeny|J|https://orcid.org/0000-0001-9082-3972', 'Patiño|Nelly|N|https://orcid.org/0000-0003-3293-2294', 'Salmeron|Jorge|J|https://orcid.org/0000-0002-5113-299X', 'Valdés-Flores|Margarita|M|https://orcid.org/0000-0001-5848-0607', 'Velázquez-Cruz|Rafael|R|https://orcid.org/0000-0003-4515-0777']
D015502:Absorptiometry, Photon D000368:Aged D015519:Bone Density D001851:Bone Diseases, Metabolic D005260:Female D005272:Femur Neck D006620:Hip Fractures D006801:Humans D008159:Lumbar Vertebrae D008565:Membrane Proteins D008800:Mexico D008875:Middle Aged D015663:Osteoporosis, Postmenopausal D058866:Osteoporotic Fractures D020641:Polymorphism, Single Nucleotide D017698:Postmenopause D011505:Protein-Tyrosine Kinases D055755:SOXD Transcription Factors D051153:Wnt Proteins
Osteoporosis fragility fracture bone mineral biomarkers density genetic association