Cheating Death: New Molecules Block BAX.
BAX is a formidable BCL-2 family protein that executes cellular suicide in response to physiologic and pathologic stress. A new article in Nature Chemical Biology (Garner et al.https://doi.org/10.1038/s41589-018-0223-0) reports small molecules that inhibit the conformational activation of BAX, informing a pharmacologic approach to blocking unwanted cell death in human disease.
['Walensky|Loren D|LD|']
D017209:Apoptosis D016923:Cell Death D055808:Drug Discovery D006801:Humans D008928:Mitochondria D019253:Proto-Oncogene Proteins c-bcl-2 D013312:Stress, Physiological D013329:Structure-Activity Relationship D051028:bcl-2-Associated X Protein
BAX BCL-2 family small molecule apoptosis inhibitor