Risk Factors and Mouse Models of Abdominal Aortic Aneurysm Rupture.
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in older adults. In clinical practice, the most established predictor of AAA rupture is maximum AAA diameter. Aortic diameter is commonly used to assess AAA severity in mouse models studies. AAA rupture occurs when the stress (force per unit area) on the aneurysm wall exceeds wall strength. Previous research suggests that aortic wall structure and strength, biomechanical forces on the aorta and cellular and proteolytic composition of the AAA wall influence the risk of AAA rupture. Mouse models offer an opportunity to study the association of these factors with AAA rupture in a way not currently possible in patients. Such studies could provide data to support the use of novel surrogate markers of AAA rupture in patients. In this review, the currently available mouse models of AAA and their relevance to the study of AAA rupture are discussed. The review highlights the limitations of mouse models and suggests novel approaches that could be incorporated in future experimental AAA studies to generate clinically relevant results.
['Krishna|Smriti Murali|SM|0000-0002-0810-5144', 'Morton|Susan K|SK|', 'Li|Jiaze|J|', 'Golledge|Jonathan|J|0000-0002-5779-8848']
D000818:Animals D001012:Aorta, Abdominal D017544:Aortic Aneurysm, Abdominal D001019:Aortic Rupture D001696:Biomechanical Phenomena D003198:Computer Simulation D004195:Disease Models, Animal D006801:Humans D051379:Mice D008955:Models, Cardiovascular D012307:Risk Factors D013314:Stress, Mechanical
abdominal aortic aneurysm aneurysm rupture aortic stiffness peak wall stress preclinical imaging rupture risk