Intraprotein signal transduction by HAMP domains: a balancing act.
HAMP domains are small protein modules that predominantly operate as signal transducers in bacterial sensor proteins most of which are membrane delimited. The domain organization of such sensors has the HAMPs localized at the intersection between the membrane-anchored input sensor and the cytosolic output machinery. The data summarized here indicate that HAMP modules use a universal signaling language in balancing the communication between diverse membrane-bound input domains and cytosolic output domains that are completely foreign to each other.
['Schultz|Joachim E|JE|', 'Kanchan|Kajal|K|', 'Ziegler|Miriam|M|']
D001426:Bacterial Proteins D008565:Membrane Proteins D008958:Models, Molecular D011487:Protein Conformation D017434:Protein Structure, Tertiary D015398:Signal Transduction
HAMP domain Signaling language Adenylate cyclase Membrane receptor