Piperazine skeleton in the structural modification of natural products: a review.
Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the development of new drug candidates with a wide range of applications. Over 100 molecules with a broad range of bioactivities, including antitumor, antibacterial, anti-inflammatory, antioxidant, and other activities, were reviewed. This article reviewed investigations regarding piperazine groups for the modification of natural product derivatives in the last decade, highlighting parameters that affect their biological activity.
['Zhang|Run-Hui|RH|', 'Guo|Hong-Yan|HY|', 'Deng|Hao|H|', 'Li|Jinzi|J|', 'Quan|Zhe-Shan|ZS|']
D000900:Anti-Bacterial Agents D001688:Biological Products D004354:Drug Screening Assays, Antitumor D010879:Piperazines D013329:Structure-Activity Relationship
Piperazine natural product pharmacological activity structure–activity relationship