Codeine-induced acute generalized exanthematous pustulosis without IL36RN mutations.
Recent studies have suggested an association between mutations in the IL-36RN gene and the onset of pustular generalized. In the literature, only one case of acute generalized exanthematous pustulosis (AGEP) induced by codeine in a patient with IL36RN mutation has been reported. Herein, we reported an unusual case of AGEP caused by codeine in a patient with a history of psoriasis and confirmed by an oral provocation test. In this case, we have shown that the IL36RN gene mutation is not a constant condition in drug-induced AGEP. Clinicians should be aware of this side effect of codeine especially, in patients with a history of psoriasis. More studies are needed to clarify the association between drug-induced AGEP and IL36RN gene mutations.
['Chadli|Zohra|Z|', 'Ladhari|Chayma|C|', 'Kerkeni|Emna|E|', 'Djobbi|Amira|A|', 'Fredj|Nadia B|NB|', 'Chaabane|Amel|A|', 'Boughattas|Naceur A|NA|', 'Aouam|Karim|K|']
D056150:Acute Generalized Exanthematous Pustulosis D000328:Adult D003061:Codeine D005260:Female D006801:Humans D007378:Interleukins D009154:Mutation D055815:Young Adult
IL36RN mutations AGEP codeine psoriasis genetics