Ex-Vivo Model Systems of Cancer-Bone Cell Interactions.
This chapter elaborates on the state-of-the-art experimental procedures utilized in ex-vivo model systems of cancer-bone cell interactions under "static and dynamic" culture conditions and their potential use to understand cellular and molecular mechanisms as well as drug testing and discovery. An additional focus of this chapter is to provide details of how to incorporate varying oxygen tension, viz., hypoxic, normoxic, and hyperoxic, in such studies and regulate the bone biology toward dissociation of the bone remodeling stages to achieve only "bone resorption" or "bone formation" individually.
['Salih|Erdjan|E|']
D000818:Animals D000831:Animals, Newborn D001862:Bone Resorption D001842:Bone and Bones D002450:Cell Communication D018929:Cell Culture Techniques D045744:Cell Line, Tumor D018920:Coculture Techniques D006801:Humans D051379:Mice D009369:Neoplasms D009924:Organ Culture Techniques D010012:Osteogenesis
Ex-vivo model systems Bone organ cultures Bone resorption and formation Roller-tube model Static and dynamic cancer-bone co-cultures Three-dimensional models