(1) H and (13) C NMR spectral assignment of N,N'-disubstituted thiourea and urea derivatives active against nitric oxide synthase.
The (1) H and (13) C NMR resonances of seventeen N-alkyl and aryl-N'-[3-hydroxy-3-(2-nitro-5-substitutedphenyl)propyl]-thioureas and ureas (1-17), and seventeen N-alkyl or aryl-N'-[3-(2-amino-5-substitutedphenyl)-3-hydroxypropyl]-thioureas and ureas (18-34), designed as NOS inhibitors, were assigned completely using the concerted application of one- and two-dimensional experiments (DEPT, HSQC and HMBC). NOESY studies confirm the preferred conformation of these compounds. Copyright © 2016 John Wiley & Sons, Ltd.
['Chayah|Mariem|M|', 'Camacho|M Encarnación|ME|', 'Carrión|M Dora|MD|', 'Gallo|Miguel A|MA|']
D066241:Carbon-13 Magnetic Resonance Spectroscopy D004791:Enzyme Inhibitors D015394:Molecular Structure D019001:Nitric Oxide Synthase D066244:Proton Magnetic Resonance Spectroscopy D012015:Reference Standards D013890:Thiourea D014508:Urea
HMBC) HMBC) NOESY 1H and 13C 1D NMR 1H/13C 2D NMR (HSQC 1H/15N 2D NMR (HSQC N,N′-disubstituted thioureas and ureas hydroxypropylthioureas hydroxypropylureas