Synthesis of cis-hydrindan-2,4-diones bearing an all-carbon quaternary center by a Danheiser annulation.
A straightforward synthetic entry to functionalized hydrindane compounds based on a rapid assembly of the core nucleus by a Danheiser cycloaddition is reported. Valuable bicyclic building blocks containing the fused five and six-membered carbocyclic ring system can be achieved in only four steps from a simple acyclic β-keto ester.
['Saborit|Gisela V|GV|', 'Cativiela|Carlos|C|0000-0003-3222-0828', 'Jiménez|Ana I|AI|', 'Bonjoch|Josep|J|0000-0002-5551-6720', 'Bradshaw|Ben|B|0000-0001-9612-9199']
Danheiser annulation alkaloid decahydroquinoline