Dendrobium sonia polysaccharide regulates immunity and restores the dysbiosis of the gut microbiota of the cyclophosphamide-induced immunosuppressed mice.
To recognize the potential medicinal value of the Dendrobium sonia, polysaccharide (DSP) was extracted, purified, and investigated for its immunomodulatory activity. In vitro, DSP was shown to enhance the viability (MTT assay) and phagocytosis of macrophages. In cyclophosphamide-induced immunosuppressed mice, DSP increased serum levels of TNF-α, IL-6 and IFN-γ (enzyme-linked immunosorbent assay, ELISA), and ameliorated the imbalance of the community of gut microbiota as detected by 16S ribosomal RNA gene sequencing. These results suggest that DSP might be beneficial for patients under immunosuppressed conditions.
['Liu|Wei|W|', 'Yan|Ran|R|', 'Zhang|Liang|L|']
D000818:Animals D003520:Cyclophosphamide D016207:Cytokines D031667:Dendrobium D064806:Dysbiosis D000069196:Gastrointestinal Microbiome D016867:Immunocompromised Host D007155:Immunologic Factors D008264:Macrophages D008297:Male D051379:Mice D009005:Monosaccharides D010587:Phagocytosis D010936:Plant Extracts D011134:Polysaccharides D000067996:RAW 264.7 Cells
Dendrobium sonia Polysaccharides Gut microbiota Immunomodulatory activity