In Situ Synthesis of Silver Nanoparticles in a Hydrogel of Carboxymethyl Cellulose with Phthalated-Cashew Gum as a Promising Antibacterial and Healing Agent.
Silver nanoparticles have been shown to possess considerable antibacterial activity, but in vivo applications have been limited due to the inherent, but low, toxicity of silver. On the other hand, silver nanoparticles could provide cutaneous protection against infection, due to their ability to liberate silver ions via a slow release mechanism, and their broad-spectrum antimicrobial action. Thus, in this work, we describe the development of a carboxymethyl cellulose-based hydrogel containing silver nanoparticles. The nanoparticles were prepared in the hydrogel in situ, utilizing two variants of cashew gum as a capping agent, and sodium borohydride as the reducing agent. This gum is non-toxic and comes from a renewable natural source. The particles and gel were thoroughly characterized through using rheological measurements, UV-vis spectroscopy, nanoparticles tracking analysis, and transmission electron microscopy analysis (TEM). Antibacterial tests were carried out, confirming antimicrobial action of the silver nanoparticle-loaded gels. Furthermore, rat wound-healing models were used and demonstrated that the gels exhibited improved wound healing when compared to the base hydrogel as a control. Thus, these gels are proposed as excellent candidates for use as wound-healing treatments.
['Lustosa|Ana Karina Marques Fortes|AKMF|', 'de Jesus Oliveira|Antônia Carla|AC|', 'Quelemes|Patrick Veras|PV|', 'Plácido|Alexandra|A|', 'da Silva|Francilene Vieira|FV|', 'Oliveira|Irisdalva Sousa|IS|', 'de Almeida|Miguel Peixoto|MP|', 'Amorim|Adriany das Graças Nascimento|ADGN|', 'Delerue-Matos|Cristina|C|', 'de Oliveira|Rita de Cássia Meneses|RCM|', 'da Silva|Durcilene Alves|DA|', 'Eaton|Peter|P|0000-0003-1821-1992', 'de Almeida Leite|José Roberto de Souza|JRS|0000-0002-1096-3236']
D031021:Anacardium D000818:Animals D000900:Anti-Bacterial Agents D002266:Carboxymethylcellulose Sodium D020136:Hydrogel, Polyethylene Glycol Dimethacrylate D008297:Male D053768:Metal Nanoparticles D008826:Microbial Sensitivity Tests D010316:Particle Size D010795:Phthalic Acids D011550:Pseudomonas aeruginosa D017208:Rats, Wistar D012212:Rheology D012834:Silver D013211:Staphylococcus aureus D014945:Wound Healing
silver nanoparticles hydrogel healing antibacterial activity cashew gum wounds