Hrr25 kinase promotes selective autophagy by phosphorylating the cargo receptor Atg19.
Autophagy is the major pathway for the delivery of cytoplasmic material to the vacuole or lysosome. Selective autophagy is mediated by cargo receptors, which link the cargo to the scaffold protein Atg11 and to Atg8 family proteins on the forming autophagosomal membrane. We show that the essential kinase Hrr25 activates the cargo receptor Atg19 by phosphorylation, which is required to link cargo to the Atg11 scaffold, allowing selective autophagy to proceed. We also find that the Atg34 cargo receptor is regulated in a similar manner, suggesting a conserved mechanism.
['Pfaffenwimmer|Thaddaeus|T|', 'Reiter|Wolfgang|W|', 'Brach|Thorsten|T|', 'Nogellova|Veronika|V|', 'Papinski|Daniel|D|', 'Schuschnig|Martina|M|', 'Abert|Christine|C|', 'Ammerer|Gustav|G|', 'Martens|Sascha|S|', 'Kraft|Claudine|C|']
D000595:Amino Acid Sequence D001343:Autophagy D000071183:Autophagy-Related Proteins D047389:Casein Kinase I D008969:Molecular Sequence Data D010766:Phosphorylation D011485:Protein Binding D054730:Protein Interaction Domains and Motifs D011499:Protein Processing, Post-Translational D021381:Protein Transport D011956:Receptors, Cell Surface D018160:Receptors, Cytoplasmic and Nuclear D012441:Saccharomyces cerevisiae D029701:Saccharomyces cerevisiae Proteins D033921:Vesicular Transport Proteins
Hrr25 kinase Atg19 Atg11 Atg34 Cvt pathway‐autophagy