The Impact of Bridging LRT on Survival in Patients Listed for Liver Transplantation.
PURPOSE
Locoregional therapy (LRT) is recommended for certain groups of patients with hepatocellular carcinoma (HCC) listed for orthotopic liver transplantation (OLT) with expected wait times greater than 6 months. A retrospective single-center study was performed to evaluate the effect of LRT on the outcomes of patients with HCC listed for OLT.


METHODS
Institutional database was reviewed to identify the patients listed for OLT with HCC (March 1998-December 2010). Patient and tumor characteristics were recorded with a follow-up period of 6.5 years from diagnosis.


RESULTS
Out of 359 listed patients, 72 patients were delisted (delisted group) and 287 underwent orthotopic liver transplantation (OLT group). One hundred fifty-five and 45 patients from the OLT and delisted groups underwent locoregional therapy (LRT), respectively. Median wait time and sum of largest tumor diameter were significantly higher for patients receiving LRT. LRT was associated with significantly better survival among delisted patients at the end of follow-up (1249.6 ± 137.4 vs. 742.1 ± 155.4 days, p = 0.028). In the OLT group, survival was similar between LRT and no LRT group, but survival was significantly better in patients with largest tumor diameter ≥30 mm (1949.4 ± 95.1 vs. 1694.8 ± 135.5, p = 0.02).


CONCLUSION
Patients with HCC and the largest tumor greater than 30 mm treated with LRT prior to OLT have improved survival compared to patients not receiving LRT. Additionally, for patients who did not undergo transplant survival is significantly longer for those receiving LRT.
['Habibollahi|Peiman|P|', 'Hunt|Stephen|S|', 'Gade|Terence|T|', 'Dagli|Mandeep S|MS|', 'Mondschein|Jeffrey I|JI|', 'Sudheendra|Deepak|D|', 'Stavropoulos|S William|SW|', 'Soulen|Michael|M|', 'Gregory|Nadolski|N|']
D006528:Carcinoma, Hepatocellular D017115:Catheter Ablation D016461:Chemoembolization, Therapeutic D005260:Female D005500:Follow-Up Studies D006801:Humans D008113:Liver Neoplasms D016031:Liver Transplantation D008297:Male D008875:Middle Aged D012189:Retrospective Studies D016019:Survival Analysis D016896:Treatment Outcome
Liver transplant Locoregional therapy Hepatocellular carcinoma Bridging therapy TACE