Volatomics in inflammatory bowel disease and irritable bowel syndrome.
Volatile organic compounds (VOCs) are produced by the human metabolism, inflammation and gut microbiota and form the basis of innovative volatomics research. VOCs detected through breath and faecal analysis hence serve as attractive, non-invasive biomarkers for diagnosing and monitoring irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). This review describes the clinical applicability of volatomics in discriminating between IBS, IBD and healthy volunteers with acceptable accuracy in breath (70%-100%) and faecal (58%-85%) samples. Promising compounds are propan-1-ol for diagnosing and monitoring of IBD patients, and 1-methyl-4-propan-2-ylcyclohexa-1,4-diene as biomarker for IBS diagnosis. However, these VOCs often seem to be related to inflammation and probably will need to be used in conjunction with other clinical evidence. Furthermore, three interventional studies underlined the potential of VOCs in predicting treatment outcome and patient follow-up. This shows great promise for future use of VOCs as non-invasive breath and faecal biomarkers in personalised medicine. However, properly designed studies that correlate VOCs to IBD/IBS pathogenesis, while taking microbial influences into account, are still key before clinical implementation can be expected.
['Van Malderen|Kathleen|K|', 'De Winter|Benedicte Y|BY|', 'De Man|Joris G|JG|', 'De Schepper|Heiko U|HU|', 'Lamote|Kevin|K|']
D015415:Biomarkers D001944:Breath Tests D005243:Feces D006801:Humans D043183:Irritable Bowel Syndrome D055432:Metabolomics D055549:Volatile Organic Compounds
inflammatory bowel disease Irritable bowel syndrome Volatile organic compounds VOC IBS IBD