Esophageal Involvement in Multiple System Atrophy.
The prevalence of esophageal involvement and its impact on clinical manifestations in patients with multiple system atrophy (MSA) remains unknown. We recruited 16 consecutive patients with dysphagia associated with MSA (MSA group) and 16 consecutive patients with dysphagia associated with amyotrophic lateral sclerosis (ALS group). We assessed the presence or absence of food stagnation within the esophagus using videofluorography. Food stagnation within the esophagus was observed in 16 patients (100 %; 7 severe, 9 mild) in the MSA group and in 4 patients (25 %; 4 mild) in the ALS group (P < 0.001). Follow-up videofluorography revealed that food stagnation in patients with MSA could exacerbate during the disease course. Patients with MSA and severe food stagnation showed a wide range of intraesophageal stasis by videofluorography. Among the 16 patients in the MSA group, 4 developed aspiration pneumonia and 1 died of suffocation associated with food regurgitation during continuous positive airway pressure therapy. In conclusion, food stagnation within the esophagus occurs more frequently in MSA patients with dysphagia than in ALS patients with dysphagia. Because food stagnation can cause serious complications such as aspiration pneumonia and suffocation, patients with MSA should be evaluated by videofluorography, especially those with stagnation in the esophageal phase.
['Taniguchi|Hiroshige|H|', 'Nakayama|Hideaki|H|', 'Hori|Kazuhiro|K|', 'Nishizawa|Masatoyo|M|', 'Inoue|Makoto|M|', 'Shimohata|Takayoshi|T|']
D000368:Aged D000369:Aged, 80 and over D003679:Deglutition D003680:Deglutition Disorders D004947:Esophagus D005260:Female D005471:Fluoroscopy D006801:Humans D007564:Japan D008297:Male D008875:Middle Aged D019578:Multiple System Atrophy D015995:Prevalence D014057:Tomography, X-Ray Computed
Esophageal involvement Multiple system atrophy Dysphagia Food stagnation Aspiration pneumonia Sudden death