Quantitative assessment of background parenchymal enhancement in breast magnetic resonance images predicts the risk of breast cancer.
The objective of this study was to evaluate the association betweenthe quantitative assessment of background parenchymal enhancement rate (BPER) and breast cancer. From 14,033 consecutive patients who underwent breast MRI in our center, we randomly selected 101 normal controls. Then, we selected 101 women with benign breast lesions and 101 women with breast cancer who were matched for age and menstruation status. We evaluated BPER at early (2 minutes), medium (4 minutes) and late (6 minutes) enhanced time phases of breast MRI for quantitative assessment. Odds ratios (ORs) for risk of breast cancer were calculated using the receiver operating curve. The BPER increased in a time-dependent manner after enhancement in both premenopausal and postmenopausal women. Premenopausal women had higher BPER than postmenopausal women at early, medium and late enhanced phases. In the normal population, the OR for probability of breast cancer for premenopausal women with high BPER was 4.1 (95% CI: 1.7-9.7) and 4.6 (95% CI: 1.7-12.0) for postmenopausal women. The OR of breast cancer morbidity in premenopausal women with high BPER was 2.6 (95% CI: 1.1-6.4) and 2.8 (95% CI: 1.2-6.1) for postmenopausal women. The BPER was found to be a predictive factor of breast cancer morbidity. Different time phases should be used to assess BPER in premenopausal and postmenopausal women.
['Hu|Xiaoxin|X|', 'Jiang|Luan|L|', 'Li|Qiang|Q|', 'Gu|Yajia|Y|']
D000328:Adult D000368:Aged D019540:Area Under Curve D001940:Breast D001943:Breast Neoplasms D005260:Female D006801:Humans D008279:Magnetic Resonance Imaging D008875:Middle Aged D016017:Odds Ratio D000072356:Parenchymal Tissue D017698:Postmenopause D011237:Predictive Value of Tests D017697:Premenopause D011379:Prognosis D012372:ROC Curve D011857:Radiographic Image Interpretation, Computer-Assisted D012189:Retrospective Studies D018570:Risk Assessment D012307:Risk Factors D012984:Software D013997:Time Factors D055815:Young Adult
quantitative assessment breast MRI BPE breast parenchymal enhancement rate