Assessment of seroprevalence against poliovirus among Italian adolescents and adults.
In 2002, the WHO European Region was declared polio-free. Nonetheless global eradication has not yet been completed and the reintroduction from at risk areas is still possible. This seroprevalence study evaluated samples collected from each Italian region in the 12-50 years old age range to assess protection against Poliovirus (PV) 1, 2 and 3 among subjects immunised with different vaccination schedules. 1073 samples (50.5% females) were examined. WHO standardized microneutralization assay was used. Seroprotection rates were 92.9%, 96.2% and 83.4%, for PV1, PV2 and PV3, respectively. Geometric Mean Titres (GMTs) were higher for PV2 (52.8) and PV1 (41.1) than for PV3 (21.0). Increasing the age, a decreasing trend in seropositivity was observed, in particular for PV3. The 2017-2019 Italian National Immunisation Plan emphasises, as primary objective, the maintenance of the polio-free status and strongly validates the 2 + 1 schedule in the first year of life with IPV vaccine associated with the administration of booster doses at 6 years and during the adolescence. Surveillance system and high population immunity are crucial to ensure the maintenance of polio-free status.
['Lupi|Silvia|S|0000-0002-5402-7888', 'Stefanati|Armando|A|0000-0001-6094-3439', 'Baldovin|Tatjana|T|0000-0002-7375-9187', 'Roman|Alberto|A|0000-0002-5043-8858', 'Baldo|Vincenzo|V|', 'Gabutti|Giovanni|G|']
D000293:Adolescent D000328:Adult D057134:Antibodies, Neutralizing D000914:Antibodies, Viral D002648:Child D060740:Disease Eradication D004196:Disease Outbreaks D005260:Female D006801:Humans D007115:Immunization Schedule D007117:Immunization, Secondary D007558:Italy D008297:Male D008875:Middle Aged D009500:Neutralization Tests D011051:Poliomyelitis D017955:Poliovirus D023321:Poliovirus Vaccines D016036:Seroepidemiologic Studies D055815:Young Adult
seroprevalence microneutralization assay seropositivity immunity poliomyelitis