Polymorphism 2184A/G in the AGER gene is not associated with diabetic retinopathy in Han Chinese patients with type 2 diabetes.
OBJECTIVE
To assess the association between the 2184A/G polymorphism in the advanced glycosylation end product-specific receptor (AGER) gene and the susceptibility to diabetic retinopathy (DR) in Han Chinese patients with type 2 diabetes mellitus (T2DM).


METHODS
This cross-sectional genotyping study included patients with T2DM with and without DR. Genotype and allele frequencies of the 2184A/G polymorphism were detected using polymerase chain reaction-restriction fragment-length polymorphism analysis.


RESULTS
This study included 943 patients with T2DM (285 with DR [DR group] and 658 without DR [NDR group]). There were no significant differences in age, sex, body mass index, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, diastolic blood pressure, glycosylated haemoglobin, fasting blood glucose, postprandial 2-hour blood glucose, and triglycerides between the two groups. The duration of T2DM and systolic blood pressure were significantly increased in the DR group compared with the NDR group. No significant differences were found in allele (A and G) and genotype (AA, AG and GG) frequencies of the 2184A/G polymorphism between the two groups.


CONCLUSION
The 2184A/G polymorphism in the AGER gene is not associated with DR in Han Chinese patients with T2DM.
['Li|Jian|J|', 'Cai|Wei|W|', 'Zhang|Wei|W|', 'Zhu|Wei-Feng|WF|', 'Liu|Ying|Y|', 'Yue|Li-Xia|LX|', 'Zhu|Ling-Yan|LY|', 'Xiao|Jun-Ren|JR|', 'Liu|Jian-Ying|JY|', 'Xu|Ji-Xiong|JX|']
D044466:Asians D003710:Demography D003924:Diabetes Mellitus, Type 2 D003930:Diabetic Retinopathy D005006:Ethnicity D005260:Female D005787:Gene Frequency D056726:Genetic Association Studies D020022:Genetic Predisposition to Disease D006801:Humans D008297:Male D008875:Middle Aged D020641:Polymorphism, Single Nucleotide D000067759:Receptor for Advanced Glycation End Products
2184A/G diabetic retinopathy Han Chinese type 2 diabetes mellitus Receptor for advanced glycation end-products (RAGE) gene polymorphism