Ethanolic carbon-11 chemistry: the introduction of green radiochemistry.
The principles of green chemistry have been applied to a radiochemistry setting. Eleven carbon-11 labeled radiopharmaceuticals have been prepared using ethanol as the only organic solvent throughout the entire manufacturing process. The removal of all other organic solvents from the process simplifies production and quality control (QC) testing, moving our PET Center towards the first example of a green radiochemistry laboratory. All radiopharmaceutical doses prepared are suitable for clinical use.
['Shao|Xia|X|', 'Fawaz|Maria V|MV|', 'Jang|Keunsam|K|', 'Scott|Peter J H|PJ|']
D002250:Carbon Radioisotopes D000431:Ethanol D055772:Green Chemistry Technology D007553:Isotope Labeling D011854:Radiochemistry D019275:Radiopharmaceuticals
Carbon-11 Green chemistry PET chemistry Positron emission tomography Radiopharmaceutical synthesis