Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease.
Dicarbonyl stress is the abnormal accumulation of dicarbonyl metabolites leading to increased protein and DNA modification contributing to cell and tissue dysfunction in ageing and disease. Enzymes metabolising dicarbonyls, glyoxalase 1 and aldoketo reductases, provide an efficient and stress-response enzyme defence against dicarbonyl stress. Dicarbonyl stress is produced by increased formation and/or decreased metabolism of dicarbonyl metabolites, and by exposure to exogenous dicarbonyls. It contributes to ageing, disease and activity of cytototoxic chemotherapeutic agents.
['Rabbani|Naila|N|', 'Thornalley|Paul J|PJ|']
D000375:Aging D000447:Aldehydes D002318:Cardiovascular Diseases D003847:Deoxyglucose D003920:Diabetes Mellitus D006037:Glyoxal D006801:Humans D007249:Inflammation D007674:Kidney Diseases D008954:Models, Biological D018384:Oxidative Stress D011765:Pyruvaldehyde D013312:Stress, Physiological
Cardiovascular disease Diabetes Glycation Hypoxia Inflammation Oxidative stress