High-energy breakfast based on whey protein reduces body weight, postprandial glycemia and HbA1C in Type 2 diabetes.
Acute studies show that addition of whey protein at breakfast has a glucose-lowering effect through increased incretin and insulin secretion. However, whether this is a long-term effect in Type 2 diabetes is unknown. Fifty-six Type 2 diabetes participants aged 58.9±4.5 years, BMI 32.1±0.9 kg/m2 and HbA1C 7.8±0.1% (61.6±0.79 mmol/mol) were randomized to one of 3 isocaloric diets with similar lunch and dinner, but different breakfast: 1) 42 g total protein, 28 g whey (WBdiet, n=19); 2) 42 g various protein sources (PBdiet, n=19); or 3) high-carbohydrate breakfast, 17 g protein from various sources (CBdiet, n=18). Body weight and HbA1C were examined after 12 weeks. All participants underwent three all-day meal challenges for postprandial glycemia, insulin, C-peptide, intact glucagon-like peptide 1 (iGLP-1), ghrelin and hunger and satiety scores. Overall postprandial AUCglucose was reduced by 12% in PBdiet and by 19% in WBdiet, compared with CBdiet (P<.0001). Compared with PBdiet and CBdiet, WBdiet led to a greater postprandial overall AUC for insulin, C-peptide, iGLP-1 and satiety scores, while postprandial overall AUC for ghrelin and hunger scores were reduced (P<.0001). After 12 weeks, HbA1C was reduced after WBdiet by 0.89±0.05% (11.5±0.6 mmol/mol), after PBdiet by 0.6±0.04% (7.1±0.31 mmol/mol) and after CBdiet by 0.36±0.04% (2.9±0.31 mmol/mol) (P<.0001). Furthermore, the participants on WBdiet lost 7.6±0.3 kg, PBdiet 6.1±0.3 kg and CBdiet 3.5±0.3 kg (P<.0001). Whey protein-based breakfast is an important adjuvant in the management of Type 2 diabetes.
['Jakubowicz|Daniela|D|', 'Wainstein|Julio|J|', 'Landau|Zohar|Z|', 'Ahren|Bo|B|', 'Barnea|Maayan|M|', 'Bar-Dayan|Yosefa|Y|', 'Froy|Oren|O|']
D001786:Blood Glucose D015992:Body Mass Index D062408:Breakfast D003131:Combined Modality Therapy D003924:Diabetes Mellitus, Type 2 D003927:Diet, Diabetic D004038:Diet, Reducing D002149:Energy Intake D005260:Female D006442:Glycated Hemoglobin A D006801:Humans D006943:Hyperglycemia D007004:Hypoglycemic Agents D008297:Male D008687:Metformin D008875:Middle Aged D009765:Obesity D012528:Satiety Response D015431:Weight Loss D000067816:Whey Proteins
Breakfast Whey Protein Weight Diabetes