Identification of degranulation inhibitors from rooibos (Aspalathus linearis) tea in rat basophilic leukaemia cells.
Quercetin, luteolin and chrysoeriol were identified from rooibos tea as degranulation inhibitors in rat basophilic leukaemia cells. The degranulation inhibitory activity of chrysoeriol was first discovered in the present study. When quercetin, luteolin and chrysoeriol were mixed in the ratio that occurs in rooibos tea extract, the mixture inhibited antigen- and calcium ionophore-stimulated degranulation to the same degree as that by the whole rooibos tea extract. These findings indicate that these three flavonoids are the key factors underlying the degranulation inhibitory activity of rooibos tea.
['Morishita|Yuta|Y|', 'Ikeda|Kaoru|K|', 'Matsuno|Hiroaki|H|', 'Ito|Hideyuki|H|', 'Tai|Akihiro|A|']
D000818:Animals D018926:Anti-Allergic Agents D036903:Aspalathus D001491:Basophils D061207:Calcium Ionophores D015550:Cell Degranulation D045744:Cell Line, Tumor D047309:Flavones D007938:Leukemia D047311:Luteolin D010936:Plant Extracts D011794:Quercetin D051381:Rats D000069459:Teas, Herbal
degranulation chrysoeriol flavonoids anti-allergy