Antibacterial Activity of Bacterial Cellulose Loaded with Bacitracin and Amoxicillin: In Vitro Studies.
The use of bacterial cellulose (BC) in skin wound treatment is very attractive due to its unique characteristics. These dressings' wet environment is an important feature that ensures efficient healing. In order to enhance the antimicrobial performances, bacterial-cellulose dressings were loaded with amoxicillin and bacitracin as antibacterial agents. Infrared characterization and thermal analysis confirmed bacterial-cellulose binding to the drug. Hydration capacity showed good hydrophilicity, an efficient dressing's property. The results confirmed the drugs' presence in the bacterial-cellulose dressing's structure as well as the antimicrobial efficiency against Staphylococcus aureus and Escherichia coli. The antimicrobial assessments were evaluated by contacting these dressings with the above-mentioned bacterial strains and evaluating the growth inhibition of these microorganisms.
['Lemnaru Popa|Georgiana-Mădălina|GM|', 'Truşcă|Roxana Doina|RD|', 'Ilie|Cornelia-Ioana|CI|', 'Țiplea|Roxana Elena|RE|', 'Ficai|Denisa|D|', 'Oprea|Ovidiu|O|0000-0002-8145-1094', 'Stoica-Guzun|Anicuța|A|', 'Ficai|Anton|A|0000-0002-1777-0525', 'Dițu|Lia-Mara|LM|0000-0002-6593-255X']
D000658:Amoxicillin D000900:Anti-Bacterial Agents D001414:Bacitracin D001419:Bacteria D002482:Cellulose D015169:Colony Count, Microbial D004926:Escherichia coli D007700:Kinetics D008826:Microbial Sensitivity Tests D008970:Molecular Weight D017550:Spectroscopy, Fourier Transform Infrared D013211:Staphylococcus aureus D013696:Temperature D014867:Water
bacterial cellulose skin wounds dressings antimicrobial effect drug delivery