Ripened Pu-erh Tea Extract Protects Mice from Obesity by Modulating Gut Microbiota Composition.
Ripened Pu-erh tea extract contributes to reducing weight gain and fat accumulation; however, the role of gut microbiota on the antiobesity effect of ripened Pu-erh tea extract in obese mice remains unclear. This study aims to explore the role of alterations in gut microbes mediated by ripened Pu-erh tea extract in obese mice through 16S rRNA sequencing and a fecal transplant trial. Our results suggested that drinking water containing ripened Pu-erh tea extract could decrease weight gain, fat accumulation, adipose inflammation, the Firmicutes-to-Bacteroidetes ratio, and metabolic endotoxemia while, in the meantime, improving the intestinal barrier integrity in obese mice. Moreover, the fecal transplant trial indicated that feces from the donor mice treated with ripened Pu-erh tea extract could significantly modulate weight and metabolic syndrome in the recipient mice. Thus, our results indicated that gut microbiota can mediate the function of ripened Pu-erh tea extract against obesity; additionally, ripened Pu-erh tea extract can potentially prevent individuals from being obese through rebalancing the gut microbiota.
['Lu|Xiaojie|X|', 'Liu|Jiuxi|J|', 'Zhang|Naisheng|N|', 'Fu|Yunhe|Y|', 'Zhang|Zecai|Z|', 'Li|Yanxin|Y|', 'Wang|Wenqing|W|', 'Li|Yanyi|Y|', 'Shen|Peng|P|', 'Cao|Yongguo|Y|http://orcid.org/0000-0002-9533-7516']
D000818:Animals D001419:Bacteria D004269:DNA, Bacterial D000069196:Gastrointestinal Microbiome D006801:Humans D007422:Intestines D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D009765:Obesity D010936:Plant Extracts D020011:Protective Agents D012336:RNA, Ribosomal, 16S D013662:Tea
ripened Pu-erh tea extract obesity gut microbiota