No improvement in serological response among serofast latent patients retreated with benzathine penicillin.
Persistent non-treponemal titres after treatment are common among patients with latent syphilis. Although retreatment is often done in clinical practice, optimal management remains uncertain due to the paucity of data regarding serological response to retreatment and long-term outcomes. We compared the serological responses of serofast latent syphilis patients retreated with 7.2 million units of benzathine penicillin with the responses of patients who did not receive retreatment (control group). We retrospectively analysed the serological response to therapy following retreatment of 35 serofast latent syphilis patients at 12 months with benzathine penicillin 2.4 million units weekly for 3 weeks. In all, 74.3% (26/35) of the cases with latent syphilis who failed to achieve serological cure at 12 months after initial therapy achieved serological cure after retreatment and after an additional 12 months of follow-up. However, statistically similar serological cure rate was observed in 80.0% (28/35) of the control group (p > .05). Our findings illustrate no improvement in serological response among serofast latent patients retreated with three doses of benzathine penicillin.
['Ren|Rong-Xin|RX|', 'Wang|Lin-Na|LN|', 'Zheng|He-Yi|HY|', 'Li|Jun|J|']
D000328:Adult D000900:Anti-Bacterial Agents D016022:Case-Control Studies D004305:Dose-Response Relationship, Drug D005260:Female D006801:Humans D008297:Male D010401:Penicillin G Benzathine D019233:Retreatment D012189:Retrospective Studies D013587:Syphilis D013588:Syphilis Serodiagnosis D013592:Syphilis, Latent D013997:Time Factors D017211:Treatment Failure D016896:Treatment Outcome
serofast retreatment benzathine penicillin treatment Syphilis RPR Treponema pallidum late latent syphilis sexually transmitted infections