Effect of gellan gum on the thermogelation property and drug release profile of Poloxamer 407 based ophthalmic formulation.
The effect of gellan gum on the gelation behavior and in-vitro release of a specific drug named pilocarpine hydrochloride from different ophthalmic formulations based on poloxamer 407 is examined. The mixture of 0.3wt% gellan gum and 18wt% poloxamer (PM) solutions show a considerable increase in gel strength in physiological condition. Gel dissolution rate from PM based formulation is significantly decreased due to the addition of gellan gum. FTIR spectra analysis witnesses an interaction in between OH groups of two polymers which accounts for lowering in gelation temperature of PM-gellan gum based formulations. It is also observed from the cryo-SEM study that the pore size of PM gel decreases with an addition of gellan gum and in-vitro release studies indicate that PM-gellan gum based formulation retain drug better than the PM solution alone. Therefore, the developed formulation has the potential to be utilized as an in-situ ophthalmic drug carrier.
['Dewan|Mitali|M|', 'Sarkar|Gunjan|G|', 'Bhowmik|Manas|M|', 'Das|Beauty|B|', 'Chattoapadhyay|Atis Kumar|AK|', 'Rana|Dipak|D|', 'Chattopadhyay|Dipankar|D|']
D060433:Administration, Ophthalmic D002626:Chemistry, Pharmaceutical D004337:Drug Carriers D065546:Drug Liberation D005782:Gels D008958:Models, Molecular D008968:Molecular Conformation D010862:Pilocarpine D020442:Poloxamer D011135:Polysaccharides, Bacterial D013696:Temperature D014783:Viscosity
Gellan gum Thermogelation property Drug release Poloxamer 407 Ophthalmic formulations