Early life seizures: evidence for chronic deficits linked to autism and intellectual disability across species and models.
Recent work in Exp Neurol by Lugo et al. (2014b) demonstrated chronic alterations in sociability, learning and memory following multiple early life seizures (ELS) in a mouse model. This work adds to the growing body of evidence supporting the detrimental nature of ELS on the developing brain to contribute to aspects of an autistic phenotype with intellectual disability. Review of the face validity of behavioral testing and the construct validity of the models used informs the predictive ability and thus the utility of these models to translate underlying molecular and cellular mechanisms into future human studies.
['Bernard|Paul B|PB|', 'Benke|Tim A|TA|']
D000818:Animals D001321:Autistic Disorder D003072:Cognition Disorders D008297:Male D018782:Maze Learning D008569:Memory Disorders D012640:Seizures D012919:Social Behavior
Early life seizure Autism Intellectual disability Learning Memory Animal model Anxiety Communication Social