Assembly of chemically modified G-rich sequences into tetramolecular DNA G-quadruplexes and higher order structures.
In this review, we introduce the biophysical and biochemical methods currently used to investigate the structures and stabilities of tetramolecular DNA G-quadruplexes containing chemical modifications. We hope this paper will guide others as they perform similar experiments leading to more information about the effects of chemical modifications on G-quadruplex formation. The structures of tetramolecular quadruplexes and some higher order structures based on tetramolecular quadruplexes are also described.
['Zhou|Jun|J|', 'Rosu|Frédéric|F|', 'Amrane|Samir|S|', 'Korkut|Dursun Nizam|DN|', 'Gabelica|Valérie|V|', 'Mergny|Jean Louis|JL|']
D001482:Base Composition D020029:Base Pairing D001483:Base Sequence D002942:Circular Dichroism D004247:DNA D004591:Electrophoresis, Polyacrylamide Gel D054856:G-Quadruplexes D006801:Humans D007700:Kinetics D009682:Magnetic Resonance Spectroscopy D013058:Mass Spectrometry D044366:Transition Temperature
G-quadruplex Chemical modification CD Mass spectrometry NMR UV