HOXA10 expression is decreased by testosterone in luteinized granulosa             cells in vitro.
Polycystic ovary syndrome (PCOS) is perhaps the most prevalent endocrine             disorder in women of reproductive age, characterized by elevated levels of circulating             androgens or clinical manifestations of androgen excess. The specific cytokine             profile of PCOS patients is probably related to the lower implantation rate, since             follicular fluid appears to function as an embryotrophic agent. For a better understanding             of the local regulation of human follicles, the present study investigated the             protein expression levels and cellular localization of HOXA10 in granulosa cells             (GCs) from women with normal ovarian function undergoing IVF due to their husbands             suffering from azoospermia. We demonstrated by immunohistochemical studies that             the expression of HOXA10 was mainly localized in the cytoplasm of GCs. Our data             indicate that these alterations were associated with changes in the expression             of ovarian transcription factors of HOXA10. GC dose-responsive decreases in HOXA10             protein were observed in response to physiological or supraphysiological concentrations             (10-4 to 10-7 M) of testosterone. These data reveal that testosterone may be involved             in HOXA10 gene regulation in GCs. Decreased HOXA10 expression in GCs treated with             testosterone suggest that this androgen is responsible for the decreased expression             of HOXA10 in PCOS patients.
['He|Hong|H|', 'Li|Tian|T|', 'Yin|Delong|D|', 'Liu|Rong|R|', 'Chen|Qionghua|Q|', 'Wang|Ji|J|', 'Zhong|Gang|G|', 'Pu|Demin|D|']
D000328:Adult D004958:Estradiol D005260:Female D015870:Gene Expression D006107:Granulosa Cells D000080905:Homeobox A10 Proteins D018398:Homeodomain Proteins D006801:Humans D011085:Polycystic Ovary Syndrome D011374:Progesterone D011962:Receptors, FSH D013739:Testosterone
HOXA10 testosterone granulosa  cells polycystic  ovary syndrome