Effects of Gut Microbiota on Drug Metabolism and Guidance for Rational Drug Use Under Hypoxic Conditions at High Altitudes.
BACKGROUND
Modern features of drug development such as low permeability, low solubility, and improved release affect the interplay of the gut microbiota and drug metabolism. In recent years, studies have established the impact of plateau hypoxia on gut microbiota, where drug use by plateau populations is affected by hypoxia- induced changes in intestinal microflora-mediated drug metabolism.


METHODS
In this review, we summarized the effects of gut microbiota on drug metabolism, and of plateau hypoxia on the intestinal flora, with the aim of providing guidance for the rational use of drugs in high-altitude populations.


RESULTS
The evidence clearly shows that alterations in gut microbiota can affect pro-drug activation, drug inactivation, and the biotransformation of xenobiotics. Additionally, plateau hypoxia alters drug metabolism by affecting intestinal flora.


CONCLUSION
This review provides an overview of the effects of gut microbiota on drug metabolism and provides guidance for rational drug use under hypoxic conditions at high altitudes.
['Zhang|Juanhong|J|', 'Zhang|Junmin|J|', 'Wang|Rong|R|', 'Jia|Zhengping|Z|']
D000531:Altitude D000818:Animals D004347:Drug Interactions D000069196:Gastrointestinal Microbiome D006801:Humans D000860:Hypoxia D004364:Pharmaceutical Preparations
gut microbiota Drug metabolism rational drug use plateau hypoxia xenobiotics. bioavailability