Harnessing the Versatility of Continuous-Flow Processes: Selective and Efficient Reactions.
There is a great need for effective transformations and a broad range of novel chemical entities. Continuous-flow (CF) approaches are of considerable current interest: highly efficient and selective reactions can be performed in CF reactors. The reaction setup of CF reactors offers a wide variety of possible points where versatility can be introduced. This article presents a number of selective and highly efficient gas-liquid-solid and liquid-solid reactions involving a range of reagents and immobilized catalysts. Enantioselective transformations through catalytic hydrogenation and organocatalytic reactions are included, and isotopically labelled compounds and pharmaceutically relevant 1,2,3-triazoles are synthesized in CF reactors. Importantly, the catalyst bed can be changed to a solid-phase peptide synthesis resin, with which peptide synthesis can be performed with the utilization of only 1.5 equivalents of the amino acid.
['Mándity|István M|IM|', 'Ötvös|Sándor B|SB|', 'Szőlősi|György|G|', 'Fülöp|Ferenc|F|']
D000470:Alkaloids D002384:Catalysis D006571:Heterocyclic Compounds D006865:Hydrogenation D060327:Solid-Phase Synthesis Techniques D013237:Stereoisomerism D014230:Triazoles
versatility continuous-flow selectivity reactors catalysis