Design, synthesis and biological evaluation of six dinuclear platinum(II) complexes.
Six dinuclear platinum(II) complexes with a chiral tetradentate ligand, (1R,1'R,2R,2'R)-N1,N1'-(1,4-phenylenebis(methylene))dicyclohexane-1,2-diamine, have been designed, synthesized and characterized. In vitro cytotoxicity evaluation of these metal complexes against human A549, HCT-116, MCF-7 and HepG-2 cell lines have been carried out. All compounds showed antitumor activity to HepG-2, HCT-116 and A549. Particularly, compounds A1 and A2 exhibited significant better activity than other four compounds and A2 even showed comparable cytotoxicity to cisplatin against HepG-2 cell line.
['Yu|Congtao|C|', 'Gao|Chuanzhu|C|', 'Bai|Linkui|L|', 'Liu|Qinghua|Q|', 'Zhang|Zhuxin|Z|', 'Zhang|Yingjie|Y|', 'Yang|Bo|B|', 'Li|Chunli|C|', 'Dong|Peng|P|', 'Sun|Xiaojun|X|', 'Qian|Yunxu|Y|']
D000970:Antineoplastic Agents D045744:Cell Line, Tumor D015195:Drug Design D004354:Drug Screening Assays, Antitumor D006801:Humans D017671:Platinum Compounds D066244:Proton Magnetic Resonance Spectroscopy D021241:Spectrometry, Mass, Electrospray Ionization
Dinuclear platinum(II) complexes Cytotoxicity Anticancer DNA insertion group