Clinical effectiveness, toxicity, and failure patterns of helical tomotherapy for postoperative oral cavity cancer patients.
BACKGROUND
The outcome of postoperative high- and intermediate-risk oral cavity cancer (OCC) patients receiving helical tomotherapy (HT) remains limited.


MATERIALS AND METHODS
Between November 2006 and November 2012, 53 postoperative high- and intermediate-risk OCC patients treated with HT were enrolled.


RESULTS
The 4-year locoregional, local, and regional control rates were 66%, 76.4%, and 94.3%, respectively. The 4-year locoregional control rates of oral tongue and buccal mucosa cancer were 88.3% and 37.1%, respectively (P=0.012). Eleven (20.8%) patients experienced locoregional failure. In-field failure occurred in six of 53 (11.3%) in the primary area and three of 53 (5.7%) in the regional lymph-node area. No marginal failure was noted. Two of 53 (3.8%) experienced out-of-field failure. The rates of grade 3 dermatitis, mucositis, and dysphagia were 11%, 34%, and 13%, respectively. No grade 3 xerostomia was noted. Grade 2 xerostomia was 33% at month 6 and declined to 0 at month 48. A rate of 56% of grade 2 trismus at month 6 was noted, and declined to around 30% after 2 years. No grade 3 trismus was noted after 2 years.


CONCLUSION
HT as a postoperative modality provided satisfying results, especially for xerostomia and trismus, and was impressive in high- and intermediate-risk OCC patients receiving postoperative HT.
['Hsieh|Chen-Hsi|CH|', 'Shueng|Pei-Wei|PW|', 'Wang|Li-Ying|LY|', 'Liao|Li-Jen|LJ|', 'Lin|Yu-Chin|YC|', 'Kuo|Ying-Shiung|YS|', 'Lo|Wu-Chia|WC|', 'Tseng|Chien-Fu|CF|', 'Tien|Hui-Ju|HJ|', 'Chou|Hsiu-Ling|HL|', 'Hsieh|Yen-Ping|YP|', 'Wu|Le-Jung|LJ|', 'Chen|Yu-Jen|YJ|']
helical tomotherapy oral cavity cancer locoregional control rate trismus concurrent chemoradiation