Acute vasodilator response to vardenafil and clinical outcome in patients with pulmonary hypertension.
PURPOSE
Acute vasodilator testing is recommended in patients with pulmonary arterial hypertension to identify individuals who may benefit from long-term treatment with oral calcium channel blockers. The aim of this study was to investigate the use of vardenafil in acute vasoreactivity testing compared to adenosine.


METHODS
A total of 20 patients eligible for right heart catheterisation were enrolled. Acute vasoreactivity testing was carried out with intravenous (iv) adenosine (n = 18) followed by oral vardenafil (n = 20). Haemodynamic responses were recorded at baseline and after 60 min (vardenafil). Responders were defined according to consensus guideline criteria.


RESULTS
Both vardenafil and adenosine significantly decreased mean pulmonary arterial pressure (mPAP, p < 0.001 and p = 0.026, respectively) and pulmonary vascular resistance (p < 0.001 and p > 0.001, respectively), and significantly increased cardiac output (p = 0.001 and p = 0.005, respectively). Vardenafil reduced mPAP more than adenosine (p = 0.044), while adenosine resulted in higher responses of cardiac index (p = 0.009) and pulmonary arterial oxygen saturation (p = 0.042). Acute adverse reactions were common with adenosine, while no side effects were observed after a single oral dose vardenafil. Vardenafil identified five responders (out of 20), while adenosine identified three responders (out of 18). During a 7-year follow-up, vardenafil responders had significantly lower NT-proBNP levels compared to non-responders.


CONCLUSIONS
Vardenafil may be safely used for acute vasoreactivity testing in patients with PH. A single oral dose of vardenafil is better tolerated than iv adenosine and may identify additional responders who could benefit from long-term vasodilator treatment.
['Sandqvist|Anna|A|', 'Henrohn|Dan|D|', 'Egeröd|Hanna|H|', 'Hedeland|Mikael|M|', 'Wernroth|Lisa|L|', 'Bondesson|Ulf|U|', 'Schneede|Jörn|J|', 'Wikström|Gerhard|G|']
D000241:Adenosine D000328:Adult D000368:Aged D001784:Blood Gas Analysis D006328:Cardiac Catheterization D004333:Drug Administration Routes D005260:Female D006439:Hemodynamics D006801:Humans D006976:Hypertension, Pulmonary D008297:Male D008875:Middle Aged D000069058:Vardenafil Dihydrochloride D014665:Vasodilator Agents
Vardenafil Pulmonary hypertension Acute vasodilator test Adenosine Right heart catheterisation Haemodynamics