Association of Psychosocial Factors With Short-Term Resting Heart Rate Variability: The Atherosclerosis Risk in Communities Study.
Background Psychosocial factors predict heart disease risk, but our understanding of underlying mechanisms is limited. We sought to evaluate the physiologic correlates of psychosocial factors by measuring their relationships with heart rate variability (HRV), a measure of autonomic health, in the ARIC (Atherosclerosis Risk in Communities) study. We hypothesize that increased psychosocial stress associates with lower HRV. Methods and Results We studied 9331 participants in ARIC with short-term HRV data at visits 2 and 4. The mean (SD) age was 54.4 (5.7) years, 55% were women, and 25% were Black. Psychosocial factors included: (1) vital exhaustion (VE), (2) anger proneness, a personality trait, and (3) perceived social support. Linear models adjusted for sociodemographic and cardiovascular risk factors. Low frequency HRV (ln ms2) was significantly lower in the highest versus lowest quartiles of VE (B=-0.14, 95% CI, -0.24 to -0.05). When comparing this effect to age (B=-0.04, 95% CI, -0.05 to -0.04), the difference was equivalent to 3.8 years of accelerated aging. Perceived social support associated with lower time-domain HRV. High VE (versus low VE) also associated with greater decreases in low frequency over time, and both anger and VE associated with greater increases in resting heart rate over time. Survival analyses were performed with Cox models, and no evidence was found that HRV explains the excess risk found with high VE and low perceived social support. Conclusions Vital exhaustion, and to a lesser extent anger and social support, were associated with worse autonomic function and greater adverse changes over time.
['Shah|Anish S|AS|', 'Alonso|Alvaro|A|', 'Whitsel|Eric A|EA|', 'Soliman|Elsayed Z|EZ|', 'Vaccarino|Viola|V|', 'Shah|Amit J|AJ|']
D050197:Atherosclerosis D001341:Autonomic Nervous System D002940:Circadian Rhythm D005260:Female D005500:Follow-Up Studies D006339:Heart Rate D006801:Humans D008297:Male D008875:Middle Aged D012146:Rest D012189:Retrospective Studies D012307:Risk Factors D013315:Stress, Psychological D013997:Time Factors
heart rate variability autonomic dysfunction depressive symptoms psychological stress somatic symptoms