An open-label, interventional, single-center, prospective clinical study to evaluate the efficacy and safety of "AHPL/AYTAB/1514" in patients suffering from halitosis.
Objectives
The main objective of the study was to assess the efficacy and safety of AHPL/AYTAB/1514 tablet in patients suffering from halitosis.


Methodology
Fifty four patients were recruited in the study. Patients were advised to take maximum two tablets or at least one tablet four times a day (depending on tolerability of the drug) orally for 60 days. Patients were called for follow-up on day 15, 30, 45, 60, and 75. Data describing quantitative measures were expressed as mean ± standard deviation comparison of variables representing categorical data were performed using Chi-square test, Student's t-test, or Wilcoxon Sign Rank test.


Results
At the end of the treatment, significant reduction in halitosis, gingivitis index, and dental plaque index was observed. Even after stoppage of treatment for 15 days after 60 days of treatment, there was no relapse in halitosis. Few patients experienced sore throat, cough, and common cold during the study, which were resolved with the treatment of AHPL/AYTAB/1514 tablet. No significant change in vital parameters and most of the safety laboratory parameters were observed. No staining on tooth was observed in any patient. Almost all patients showed excellent improvement as per global evaluation done by the physician and patient. Almost all patients showed excellent tolerability to the study drug. Few patients showed mild AE, which were resolved without stoppage of study drug.


Conclusion
The study provides good evidence in support of the efficacy and safety of the AHPL/AYTAB/1514 tablet in halitosis.
['Chunawala|Yusuf K|YK|', 'Nipanikar|Sanjay|S|', 'Morawala|Abdul K|AK|', 'Talathi|Rohan D|RD|', 'Shaikh|Salika|S|', 'Upasani|Sachin A|SA|', 'Kumbhar|Vidyadhar S|VS|']
D000284:Administration, Oral D000293:Adolescent D000328:Adult D030024:Curcuma D003773:Dental Plaque D003774:Dental Plaque Index D005260:Female D005891:Gingivitis D006209:Halitosis D006801:Humans D008297:Male D027541:Mentha D008875:Middle Aged D031701:Piper D010936:Plant Extracts D011446:Prospective Studies D011788:Quality of Life D013607:Tablets D016896:Treatment Outcome D055815:Young Adult
halitosis AHPL/AYTAB/1514 tablet gingivitis dental plaque