Seizure in Indonesian Glioma Patients: Associated Risk Factors and Impact on Survival.
OBJECTIVE
Seizure is commonly found in patients with glioma. This study aimed to find risk factors for seizures in Indonesian patients with glioma. We also sought to determine the association between seizure and survival in this patient population.


METHODS
Patients with glioma were enrolled from the Dr. Sardjito General Hospital and other hospitals in Yogyakarta Province, Indonesia. Detailed demographic and clinical data were collected from medical records. DNA extraction and polymerase chain reaction (PCR) were performed to detect IDH1 mutation. Tumor tissue samples were stained by hematoxylin-eosin and classified according to the 2016 World Health Organization (WHO) classification of central nervous system (CNS) tumors. Expression of Ki-67 was detected by immunohistochemistry staining. Survival data were also collected.


RESULTS
In total, 107 patients were included in the analysis. Age, gender, history of smoking, tumor side, tumor grade, Ki-67 expression, and IDH1 mutation were not associated with seizure. Tumors involving the frontal lobe (p=0.037) and oligodendroglioma histology (p=0.031) were associated with the development of seizures in this study. However, multivariate analysis showed that only oligodendrogial histology was associated with seizure [p=0.032, odds ratio (OR) = 4.77, 95% confidence interval (CI) = 1.146-19.822]. Patients with seizures have significantly longer median overall survival than patients without seizures (69.3±25.01 vs. 10.6±6.14 months, respectively, p=0.04).


CONCLUSION
This study showed that seizure in patients with glioma in Indonesia is associated with frontal lobe location and oligodendroglioma histology. Patients with seizures also have significantly longer overall survival. <br />.
['Hartanto|Rahmat Andi|RA|', 'Dwianingsih|Ery Kus|EK|', 'Panggabean|Andre Stefanus|AS|', 'Wicaksono|Adiguno Suryo|AS|', 'Dananjoyo|Kusumo|K|', 'Asmedi|Ahmad|A|', 'Malueka|Rusdy Ghazali|RG|']
D000328:Adult D001932:Brain Neoplasms D005260:Female D005625:Frontal Lobe D005910:Glioma D006801:Humans D007214:Indonesia D008297:Male D008875:Middle Aged D016017:Odds Ratio D009837:Oligodendroglioma D011379:Prognosis D012307:Risk Factors D012640:Seizures D015996:Survival Rate D055815:Young Adult
seizure Glioma risk factors survival