High-intensity interval exercise and hypoglycaemia minimisation in adults with type 1 diabetes: A randomised cross-over trial.
AIMS
We aimed to examine the feasibility and safety of undertaking high-intensity interval exercise (HIIE) with evening basal insulin dose reduction on exercise-related hypoglycaemia following an afternoon bout of HIIE, compared with moderate-intensity continuous exercise and a non-exercise control day in adults with type 1 diabetes in a free-living environment.


METHODS
Twelve adults with type 1 diabetes participated in a randomised, crossover trial (9 female/3 male, mean age 40.4 ± 9.9 years, duration 16.5 ± 9.8 years, HbA1c 8.0 ± 0.8%). Each participant undertook five conditions: a non-exercise day, and four exercise conditions on separate afternoons: a moderate-intensity continuous exercise bout; and three HIIE bouts with 10%, 20% and 30% evening basal insulin reduction. Post-exercise glucose response was measured for 24 h by continuous glucose monitoring and compared across conditions.


RESULTS
HIIE with 10%, 20% and 30% evening basal insulin dose reduction was not associated with an increase in hypoglycaemia compared with moderate-intensity continuous exercise, or the non-exercise day. There was no difference in hyperglycaemia, time-in-range or glucose variability across all exercise regimens and the non-exercise day (p > .05).


CONCLUSIONS
Exercise-related hypoglycaemia was not increased following afternoon HIIE when diabetes management strategies incorporating evening basal insulin dose reduction were utilised.
['Lee|Angela S|AS|', 'Way|Kimberley L|KL|', 'Johnson|Nathan A|NA|', 'Twigg|Stephen M|SM|']
D000328:Adult D001786:Blood Glucose D015190:Blood Glucose Self-Monitoring D018592:Cross-Over Studies D003922:Diabetes Mellitus, Type 1 D015444:Exercise D005240:Feasibility Studies D005260:Female D000072696:High-Intensity Interval Training D006801:Humans D007003:Hypoglycemia D007328:Insulin D008297:Male D008875:Middle Aged D016896:Treatment Outcome
High-intensity interval exercise Exercise Hypoglycaemia Type 1 diabetes