Twice daily short-message-based re-education could improve Helicobacter pylori eradication rate in young population: A prospective randomized controlled study.
BACKGROUND
To investigate the effects of twice daily short-message-based re-education (SMRE) before taking medicine for Helicobacter pylori (H pylori) eradication.


MATERIALS AND METHODS
Treatment-naive patients with H pylori infection were prescribed 14-day quadruple regimen consisting of lansoprazole 30 mg, colloidal bismuth pectin 200 mg, amoxicillin 1000 mg, and clarithromycin 500 mg twice daily. Patients were randomly allocated to SMRE group or control group. Patients in control group received oral and written instructions at outpatient clinic. In contrast, patients in the SMRE group received extra short messages including dosage and time of administration twice daily. Successful H pylori eradication was assessed using the 13 C-urea breath test 6 weeks after treatment. The compliance, adverse events, and patient satisfaction were also analyzed.


RESULTS
A total of 310 patients were enrolled in the intention-to-treat (ITT) and 283 in the per-protocol (PP) analysis. For young patients, the eradication rates were significantly higher in SMRE group than those in control group in PP analysis (88.6% vs 71.2%, P = 0.036), while for patients of all age groups, the eradication rate improvements were not statistically significant. The eradication rates in SMRE group and control group were 74.2% and 67.7% (P = 0.211) in ITT analysis and 82.1% and 73.4% (P = 0.078) in PP analysis, respectively. The compliance in SMRE group was significantly better than that in control group (84.8% vs 72.8%, P = 0.011).


CONCLUSIONS
Twice daily SMRE could improve the eradication rate in young population, as well as the compliance with treatment during H pylori eradication.
['Wang|Tongyu|T|', 'Yang|Xiaoxiao|X|', 'Li|Yueyue|Y|', 'Li|Lixiang|L|', 'Liu|Jing|J|', 'Ji|Chaoran|C|', 'Sun|Yiyuan|Y|', 'Li|Yanqing|Y|', 'Zuo|Xiuli|X|https://orcid.org/0000-0002-2942-1744']
D000293:Adolescent D000328:Adult D000368:Aged D000658:Amoxicillin D000900:Anti-Bacterial Agents D001729:Bismuth D017291:Clarithromycin D060740:Disease Eradication D004359:Drug Therapy, Combination D005260:Female D016481:Helicobacter Infections D016480:Helicobacter pylori D006801:Humans D064747:Lansoprazole D008297:Male D008875:Middle Aged D010353:Patient Education as Topic D010368:Pectins D011446:Prospective Studies D060145:Text Messaging D055815:Young Adult
short-message-based re-education Helicobacter pylori eradication compliance