The IL-33-ST2-MyD88 axis promotes regulatory T cell proliferation in the murine liver.
Hepatic Foxp3+ Treg cells are crucial for maintaining local immune homeostasis in the liver. However, the environmental cues required for hepatic Treg cell homeostasis are unclear. In this study, we showed that the IL-33 receptor ST2 was preferentially expressed on Treg cells in the mouse liver, but it was more lowly expressed in the spleen, mesenteric lymph nodes, and blood. More importantly, we found that IL-33 promoted the proliferation of hepatic Treg cells through myeloid differentiation factor MyD88 signaling concomitant with increased cyclin-dependent kinase 4 and cyclin D1 expression. These results suggest that IL-33 is a potential tissue-specific factor controlling Treg cell homeostasis via increased Treg proliferation in the liver.
['Xu|Lei|L|', 'Li|Wei|W|', 'Wang|Xiaofan|X|', 'Zhang|Lina|L|', 'Qi|Qianqian|Q|', 'Dong|Liyang|L|', 'Wei|Chuan|C|', 'Pu|Yanan|Y|', 'Li|Yalin|Y|', 'Zhu|Jifeng|J|', 'Zhou|Sha|S|', 'Liu|Feng|F|', 'Chen|Xiaojun|X|', 'Su|Chuan|C|0000-0002-8271-2428']
D000818:Animals D049109:Cell Proliferation D019938:Cyclin D1 D051358:Cyclin-Dependent Kinase 4 D000072179:Interleukin-1 Receptor-Like 1 Protein D000067596:Interleukin-33 D008099:Liver D008198:Lymph Nodes D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D018345:Mice, Knockout D053594:Myeloid Differentiation Factor 88 D015398:Signal Transduction D013154:Spleen D050378:T-Lymphocytes, Regulatory
Liver Treg IL-33 ST2 MyD88