IL17A and IL23R gene polymorphisms affect the clinical features and prognosis of patients with multiple myeloma.
Single nucleotide polymorphisms (SNPs) in interleukin 17 (IL17A) and IL-23 receptor (IL23R) are involved in the pathogenesis of many cancers and autoimmune diseases. We investigated the influence of IL17A and IL23R SNPs on the risk of developing multiple myeloma (MM) and its clinical features. We obtained genomic DNA from 120 patients with MM and 201 healthy controls and detected IL17A -197 G/A (rs2275913) and IL23R H3Q (rs1884444) genotypes using the polymerase chain reaction-restriction fragment length polymorphism method. There were no significant differences in the genotype and allele frequencies of IL17A -197 G/A and IL23R H3Q between the controls and patients with MM. Compared with the GG and GA genotypes, the IL17A AA genotype was significantly associated with lower hemoglobin levels. The IL23R HH genotype was significantly associated with higher frequency of bone lesions and plasmacytoma than the HQ and QQ genotypes. We observed significant differences in overall survival (OS) between patients treated with thalidomide and/or bortezomib and those treated conventionally. Therefore, we also examined the effect of IL17A and IL23R polymorphisms on the clinical variables and OS in patients treated with thalidomide and/or bortezomib. We observed that the IL23R HH genotype was significantly associated with poor survival compared with the QH and HH genotypes in these patients. Our findings indicate that IL17A -197 G/A and IL23R H3Q are not associated with susceptibility to MM. However, IL-17 and IL-23R polymorphisms may affect severity, bone lesions, and extra-medullary disease in patients with MM. Moreover, IL23R polymorphisms may contribute to poor prognosis in patients with MM treated with thalidomide and/or bortezomib.
['Kasamatsu|Tetsuhiro|T|http://orcid.org/0000-0002-7943-9176', 'Kimoto|Mari|M|', 'Takahashi|Noriyuki|N|', 'Minato|Yusuke|Y|', 'Gotoh|Nanami|N|', 'Takizawa|Makiko|M|', 'Matsumoto|Morio|M|', 'Sawamura|Morio|M|', 'Yokohama|Akihiko|A|', 'Handa|Hiroshi|H|', 'Tsukamoto|Norifumi|N|', 'Saitoh|Takayuki|T|', 'Murakami|Hirokazu|H|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D005260:Female D005838:Genotype D006801:Humans D020381:Interleukin-17 D008297:Male D008875:Middle Aged D009101:Multiple Myeloma D020641:Polymorphism, Single Nucleotide D011379:Prognosis D018123:Receptors, Interleukin D016019:Survival Analysis
polymorphism multiple myeloma interleukin-17A interleukin-23 receptor