Influence of chronic cadmium exposure on the tissue distribution of copper and zinc and oxidative stress parameters in rats.
The aim of this study was to investigate the effect of oral cadmium (Cd) intoxication on the antioxidant response and its relationship with essential bioelements like copper (Cu) and zinc (Zn). The experimental group was chronically exposed to Cd daily for 8 weeks via consumption of water containing 15 ppm cadmium chloride. Cu, Zn, and Cd concentrations and oxidative stress parameters were analyzed in liver, kidney, and heart tissues. Exposure to Cd led to a significant decrease in the activities of superoxide dismutase in all considered samples while a significant increase in the activity of glutathione peroxidase except for the kidney. We found a significant increase in malondialdehyde concentration in the tissues except for heart. Also oral administration of Cd caused a significant reduction of Zn and Cu in the tissues. Our results allow us to hypothesize that higher Cd concentration in the tissues causes oxidative stress by increasing malondialdehyde as a means of altering antioxidant defense system and deterioration of bioelements in rat liver, kidney, and heart. In addition, further studies are needed to explain the effect of long-term, low-dose exposure to Cd on distribution of bioelements and its relationship with oxidative stress.
['Erdem|Onur|O|', 'Yazihan|Nuray|N|', 'Kocak|Mehtap Kacar|MK|', 'Sayal|Ahmet|A|', 'Akcil|Ethem|E|']
D000284:Administration, Oral D000818:Animals D015415:Biomarkers D002104:Cadmium D003300:Copper D004785:Environmental Pollutants D006321:Heart D007668:Kidney D015227:Lipid Peroxidation D008099:Liver D008297:Male D008315:Malondialdehyde D009206:Myocardium D018384:Oxidative Stress D010088:Oxidoreductases D011897:Random Allocation D017208:Rats, Wistar D014018:Tissue Distribution D036401:Toxicity Tests, Chronic D066007:Toxicokinetics D014131:Trace Elements D015032:Zinc
cadmium copper zinc oxidative stress Antioxidant enzymes