Suppressive effects of neonatal bisphenol A on the neuroendocrine system.
The aim of this study was to assess the effects of neonatal bisphenol A (BPA) administration on neuroendocrine features (the thyroid-brain axis). BPA (20 or 40 µg/kg) was orally administered to juvenile male albino rats ( Rattus norvegicus) from postnatal days (PNDs) 15 to 30. Both doses resulted in lower serum thyroxine (T4), triiodothyronine (T3), and growth hormone levels and higher thyrotropin level than the control levels at PND 30. In the neonatal cerebellum and cerebrum, vacuolation, pyknosis, edema, degenerative changes, and reductions in the size and number of the cells were observed in both treated groups. Alternatively, elevations in oxidative markers (lipid peroxidation, nitric oxide, and hydrogen peroxide [H2O2]) at both dose levels were recorded at PND 30, along with decreased activities of antioxidant markers (ascorbic acid, total thiol [t-SH], glutathione, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, and catalase) with respect to control levels. Thus, the BPA-induced hypothyroid state may disturb the neonatal thyroid-brain axis via production of free radicals, and this could damage the plasma membrane and cellular components, delaying cerebrum and cerebellum development.
['Ahmed|R G|RG|', 'Walaa|G H|GH|', 'Asmaa|F S|FS|']
D000818:Animals D000831:Animals, Newborn D000975:Antioxidants D001559:Benzhydryl Compounds D015415:Biomarkers D002531:Cerebellum D054022:Cerebrum D008297:Male D009490:Neurosecretory Systems D010636:Phenols D051381:Rats D013961:Thyroid Gland D013963:Thyroid Hormones
Bisphenol A cerebellum cerebrum antioxidants prooxidants thyroid hormones