A Supramolecular Antibiotic Switch for Antibacterial Regulation.
A supramolecular antibiotic switch is described that can reversibly "turn-on" and "turn-off" its antibacterial activity on demand, providing a proof-of-concept for a way to regulate antibacterial activity of biotics. The switch relies on supramolecular assembly and disassembly of cationic poly(phenylene vinylene) derivative (PPV) with cucurbit[7]uril (CB[7]) to regulate their different interactions with bacteria. This simple but efficient strategy does not require any chemical modification on the active sites of the antibacterial agent, and could also regulate the antibacterial activity of classical antibiotics or photosensitizers in photodynamic therapy. This supramolecular antibiotic switch may be a successful strategy to fight bacterial infections and decrease the emergence of bacterial resistance to antibiotics from a long-term point of view.
['Bai|Haotian|H|', 'Yuan|Huanxiang|H|', 'Nie|Chenyao|C|', 'Wang|Bing|B|', 'Lv|Fengting|F|', 'Liu|Libing|L|', 'Wang|Shu|S|']
D000900:Anti-Bacterial Agents D001952:Bridged-Ring Compounds D004305:Dose-Response Relationship, Drug D004352:Drug Resistance, Microbial D004926:Escherichia coli D007093:Imidazoles D046911:Macromolecular Substances D008826:Microbial Sensitivity Tests D015394:Molecular Structure D010778:Photochemotherapy D017319:Photosensitizing Agents D011145:Polyvinyls D013329:Structure-Activity Relationship
antibiotics antibacterial regulation supramolecular assembly bacterial resistance molecular switches