Amyloid precursor protein and neural development.
Interest in the amyloid precursor protein (APP) has increased in recent years due to its involvement in Alzheimer's disease. Since its molecular cloning, significant genetic and biochemical work has focused on the role of APP in the pathogenesis of this disease. Thus far, however, these studies have failed to deliver successful therapies. This suggests that understanding the basic biology of APP and its physiological role during development might be a crucial missing link for a better comprehension of Alzheimer's disease. Here, we present an overview of some of the key studies performed in various model organisms that have revealed roles for APP at different stages of neuronal development.
['Nicolas|Maya|M|', 'Hassan|Bassem A|BA|']
D000544:Alzheimer Disease D016564:Amyloid beta-Protein Precursor D000818:Animals D017173:Caenorhabditis elegans D004331:Drosophila melanogaster D006801:Humans D051379:Mice D008959:Models, Neurological D009024:Morphogenesis D009420:Nervous System D016501:Neurites D055495:Neurogenesis D017434:Protein Structure, Tertiary D013045:Species Specificity D013569:Synapses D015027:Zebrafish
Amyloid precursor protein Neural development Axonal outgrowth Synapse formation