Extranodal natural killer/T-cell lymphoma, nasal type: a Spanish multicentric retrospective survey.
BACKGROUND
Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is an aggressive lymphoma with a very low incidence in western populations.


OBJECTIVE
To review the clinicopathological features and outcome of a multicentre series of ENKTL in Spain.


MATERIALS & METHODS
A multicentre retrospective study was performed based on cases of ENKTL, collected from 1995 to 2004, from 12 dermatology departments included in the Spanish Lymphoma Study Group. The clinical, histopathological, and evolutive features of all these cases were reviewed.


RESULTS
Eighteen patients (three male, 15 female) with median age of 67 years were included in the study. The onset of lesions occurred in the nasal region in 11 patients and on the skin outside this region in the remaining cases. The observed lesions were clinically heterogeneous, corresponding to papules, plaques, and nodules, with or without ulceration. All patients except four received different polychemotherapy regimens, either alone (n = 11) or in combination with radiotherapy (n = 4). After a variable follow-up period (1-36 months), only two patients remained alive. One patient was recently diagnosed (four months ago) with ENKTL in the nasal region and the other presented with skin-limited disease. The median overall survival was 9.5 months.


CONCLUSIONS
The results of this retrospective survey confirm that ENKTL is a rare subtype of lymphoma in the Spanish population. All patients showed an aggressive clinical course and poor prognosis, regardless of the initial clinical presentation. Prospective data on larger series of patients treated homogenously are needed to establish the best treatment modality.
['Rozas-Muñoz|Eduardo|E|', 'Gallardo|Fernando|F|', 'Pujol|Ramon Maria|RM|', 'Pérez-Ferriols|Amparo|A|', 'Servitje|Octavio|O|', 'Estrach|Teresa|T|', 'Bastida|Jesus|J|', 'Román|Concha|C|', 'Palacio-Aller|Lucia|L|', 'Gil|Inmaculada|I|', 'Martí|Rosa Maria|RM|', 'Vidal-Sarró|David|D|', 'García-Muret|María Pilar|MP|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D005260:Female D006801:Humans D016130:Immunophenotyping D054391:Lymphoma, Extranodal NK-T-Cell D008297:Male D008875:Middle Aged D009669:Nose Neoplasms D012878:Skin Neoplasms D013030:Spain D011795:Surveys and Questionnaires D016896:Treatment Outcome
ENKTL Spain clinical survival prognosis treatment extranodal natural killer/T-cell lymphoma nasal type histology