Influence of nutritional status and frailty phenotype on health-related quality of life of patients with bladder or kidney cancer.
PURPOSE
This research aimed to assess the impact of nutritional status and frailty in the health-related quality of life (HRQoL) of patients with bladder or kidney cancer.


METHODS
This was a cross-sectional study with individuals aged 20 years or older. Frailty phenotype was defined using the criteria of Fried et al. (2001). Patient-Generated Subjective Global Assessment (PG-SGA) classified nutritional status. The European Organization for Research and Treatment of Cancer Quality of life questionnaire Core-30 third version (EORTC QLQ-C30) assessed HRQoL.


RESULTS
Forty-four patients with bladder and 44 with kidney cancer, mostly male, with a mean age of 65.9 and 58.6 years, respectively, were evaluated. Presence of frailty was not different between young and older adults. More than 80% of the robust subjects were well-nourished, while there was a predominance of frail with some degree of malnutrition (p < 0.05). The summary score of HRQoL was worse among the frails than pre-frails and robusts, both in bladder (68.5 vs 86.8 vs 89.5; p = 0.002) and in kidney cancer (54.9 vs 82.9 vs 91.4; p < 0.001), as well as in malnourished compared to well-nourished with bladder (72.9 vs 90.3; p = 0.003) and kidney cancer (69.4 vs 88.3; p = 0.001). After adjusted, frailty and malnutrition continued associated with poor summary score (p < 0.05).


CONCLUSION
These findings indicate that frailty and malnutrition negatively affect HRQoL of patients with bladder or kidney cancer in several aspects.
['Dos Reis|Patrícia Fonseca|PF|http://orcid.org/0000-0001-6399-8718', 'de França|Patrícia Sousa|PS|', 'Dos Santos|Mylena Pinto|MP|', 'Martucci|Renata Brum|RB|']
D000368:Aged D003430:Cross-Sectional Studies D005260:Female D000073496:Frailty D006801:Humans D007680:Kidney Neoplasms D008297:Male D044342:Malnutrition D008875:Middle Aged D009752:Nutritional Status D011788:Quality of Life D001743:Urinary Bladder D001749:Urinary Bladder Neoplasms
Frailty Quality of life Kidney cancer Malnutrition Bladder cancer