Enhanced oral bioavailability and gastroprotective effect of ibuprofen through mixed polymer-lipid nanoparticles.
Objectives: The aim of this study was to design and formulate mixed polymer-lipid nanoparticles (PLNs) for the delivery of ibuprofen. Methods: The mixed PLNs were prepared by a single modified emulsification solvent evaporation method. Key findings: Core-shell-shaped mixed PLNs were successfully prepared, with sizes in the nano range (193.3 ± 0.70 to 795.8 ± 0.70 nm) and ζ potential (-26.8 ± 0.45 to -42.8 ± 0.30 mV). Entrapment efficiency ranged from 80.3 to 93.6%. Conclusions: Pharmacokinetic parameters showed great improvement in Cmax and Tmax of ibuprofen from the formulation PLNs8 compared with the respective Brufen® and pure drugs, indicating improvement in bioavailability of the drug.
['Al-Thamarani|Sadeq|S|0000-0002-3746-1033', 'Gardouh|Ahmed|A|0000-0002-5387-1614']
D001682:Biological Availability D004337:Drug Carriers D007052:Ibuprofen D019344:Lactic Acid D008055:Lipids D053758:Nanoparticles D010316:Particle Size D011108:Polymers
ibuprofen Box–Behnken design PLGA Wistar rats poly(lactic-co-glycolic acid) polymer–lipid nanoparticles