Statins reduce the expressions of Tim-3 on NK cells and NKT cells in atherosclerosis.
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitors (statins) have an immuno-regulatory effect in addition to lowing-lipids. Accumulated evidence showed that the expressions of T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) on natural killer (NK) cells increased in atherosclerotic patients and animal models. In this study, 14 patients treated with rosuvastatin and 12 patients with atorvastatin for more than 3 months were included and 20 patients without statins treatment as control. Both statins treatment reduced the expressions of Tim-3 on NK cells and their subtypes, natural killer T (NKT) cells and CD3+ T cells, and increased the proportions of NKT cells among peripheral blood mononuclear cells, accompanied by the decreased levels of total cholesterol, low density lipoprotein, and increased ratios of high density lipoprotein to cholesterol. These may contribute to the functions of statins in the treatment of atherosclerosis.
['Zhang|Na|N|', 'Zhang|Min|M|', 'Liu|Ru-Tao|RT|', 'Zhang|Peng|P|', 'Yang|Chun-Lin|CL|', 'Yue|Long-Tao|LT|', 'Li|Heng|H|', 'Li|Yong-Kang|YK|', 'Duan|Rui-Sheng|RS|']
D000328:Adult D000368:Aged D050197:Atherosclerosis D000069059:Atorvastatin D017252:CD3 Complex D002784:Cholesterol D005260:Female D000072597:Hepatitis A Virus Cellular Receptor 2 D006801:Humans D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors D007694:Killer Cells, Natural D008075:Lipoproteins, HDL D008077:Lipoproteins, LDL D008297:Male D008875:Middle Aged D055611:Natural Killer T-Cells D000068718:Rosuvastatin Calcium D013601:T-Lymphocytes
Statin Tim-3 Atherosclerosis Natural killer T cell Natural killer cell