Mechanical Properties of the Composite Material consisting of β-TCP and Alginate-Di-Aldehyde-Gelatin Hydrogel and Its Degradation Behavior.
This work aimed to determine the influence of two hydrogels (alginate, alginate-di-aldehyde (ADA)/gelatin) on the mechanical strength of microporous ceramics, which have been loaded with these hydrogels. For this purpose, the compressive strength was determined using a Zwick Z005 universal testing machine. In addition, the degradation behavior according to ISO EN 10993-14 in TRIS buffer pH 5.0 and pH 7.4 over 60 days was determined, and its effects on the compressive strength were investigated. The loading was carried out by means of a flow-chamber. The weight of the samples (manufacturer: Robert Mathys Foundation (RMS) and Curasan) in TRIS solutions pH 5 and pH 7 increased within 4 h (mean 48 ± 32 mg) and then remained constant over the experimental period of 60 days. The determination surface roughness showed a decrease in the value for the ceramics incubated in TRIS compared to the untreated ceramics. In addition, an increase in protein concentration in solution was determined for ADA gelatin-loaded ceramics. The macroporous Curasan ceramic exhibited a maximum failure load of 29 ± 9.0 N, whereas the value for the microporous RMS ceramic was 931 ± 223 N. Filling the RMS ceramic with ADA gelatin increased the maximum failure load to 1114 ± 300 N. The Curasan ceramics were too fragile for loading. The maximum failure load decreased for the RMS ceramics to 686.55 ± 170 N by incubation in TRIS pH 7.4 and 651 ± 287 N at pH 5.0.
['Seidenstuecker|Michael|M|0000-0001-6643-6358', 'Schmeichel|Thomas|T|', 'Ritschl|Lucas|L|0000-0002-9629-8774', 'Vinke|Johannes|J|', 'Schilling|Pia|P|0000-0002-6160-9253', 'Schmal|Hagen|H|0000-0002-8801-2385', 'Bernstein|Anke|A|0000-0003-1407-3529']
mechanical properties β-TCP degradation behavior ADA-gelatin gels fracture strength