Bioglass®/chitosan-polycaprolactone bilayered composite scaffolds intended for osteochondral tissue engineering.
Polymer-coated 45S5 Bioglass(®) (BG)/chitosan-polycaprolactone (BG/CS-PCL) bilayered composite scaffolds were prepared via foam replication and freeze-drying techniques for application in osteochondral tissue engineering. The CS-PCL coated and uncoated BG scaffolds were characterized by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The mechanical properties of the coated scaffolds were significantly improved in comparison to uncoated scaffolds. The bioactivity and biodegradation behavior of scaffolds were studied in simulated body fluid (SBF) for up to 28 days. The interface between the BG scaffold and the polymer coating layer was observed by SEM and a suitable interpenetration of the polymer into the scaffold struts was found. The effects of coated and uncoated BG scaffolds on MG-63 osteoblast-like cells were evaluated by cell viability, adhesion and proliferation.
['Yao|Qingqing|Q|', 'Nooeaid|Patcharakamon|P|', 'Detsch|Rainer|R|', 'Roether|Judith A|JA|', 'Dong|Yanming|Y|', 'Goudouri|Ourania-Menti|OM|', 'Schubert|Dirk W|DW|', 'Boccaccini|Aldo R|AR|']
D001842:Bone and Bones D002356:Cartilage D002448:Cell Adhesion D045744:Cell Line, Tumor D049109:Cell Proliferation D002470:Cell Survival D002516:Ceramics D020099:Coated Materials, Biocompatible D005898:Glass D006801:Humans D010006:Osteoblasts D011091:Polyesters D054457:Tissue Scaffolds
bioglass® osteochondral tissue engineering bilayered scaffolds chitosan polycaprolactone