Soluble transferrin receptor and soluble transferrin receptor/log ferritin index in diagnosis of iron deficiency anemia in pediatric inflammatory bowel disease.
BACKGROUND
There is no single reliable marker of iron homeostasis in inflammatory bowel disease.


AIMS
To determine diagnostic usefulness of soluble transferrin receptor and soluble transferrin receptor/log ferritin index in iron deficiency anemia in children with inflammatory bowel disease.


METHODS
We assessed soluble transferrin receptor in serum and calculated soluble transferrin receptor/log ferritin index in 75 children with inflammatory bowel disease. Diagnostic ability to identify iron deficiency anemia was examined by receiver operating characteristic analysis.


RESULTS
Study group comprised 27 cases of iron deficiency anemia, 6 anemia of chronic disease with iron deficiency, 5 anemia of chronic disease. Soluble transferrin receptor was significantly increased in children with iron deficiency anemia (median: 1.63 μg/ml) compared to non-anemic children (median: 1.02 μg/ml). Soluble transferrin receptor/log ferritin index was significantly higher in iron deficiency anemia (median: 1.76) than in anemia of chronic disease (median: 0.55), anemia of chronic disease with iron deficiency (median: 0.68) or patients without anemia (median: 0.72). Soluble transferrin receptor and its index were not correlated with disease activity or inflammatory markers. Diagnostic power for soluble transferrin receptor/log ferritin index (0.864) was superior to soluble transferrin receptor (0.768) in iron deficiency anemia recognition.


CONCLUSION
Soluble transferrin receptor/log ferritin index has better diagnostic utility than soluble transferrin receptor for iron deficiency anemia detection in pediatric inflammatory bowel disease.
['Krawiec|Paulina|P|', 'Pac-Kożuchowska|Elżbieta|E|']
D000293:Adolescent D018798:Anemia, Iron-Deficiency D015415:Biomarkers D002648:Child D002908:Chronic Disease D005260:Female D005293:Ferritins D006801:Humans D015212:Inflammatory Bowel Diseases D000090463:Iron Deficiencies D008297:Male D011044:Poland D012372:ROC Curve D011990:Receptors, Transferrin
Children Crohn’s disease Erythropoiesis Inflammation Ulcerative colitis