The Role of Macrophages in the Pathogenesis of SARS-CoV-2-Associated Acute Respiratory Distress Syndrome.
Macrophages are cells that mediate both innate and adaptive immunity reactions, playing a major role in both physiological and pathological processes. Systemic SARS-CoV-2-associated complications include acute respiratory distress syndrome (ARDS), disseminated intravascular coagulation syndrome, edema, and pneumonia. These are predominantly effects of massive macrophage activation that collectively can be defined as macrophage activation syndrome. In this review we focus on the role of macrophages in COVID-19, as pathogenesis of the new coronavirus infection, especially in cases complicated by ARDS, largely depends on macrophage phenotypes and functionalities. We describe participation of monocytes, monocyte-derived and resident lung macrophages in SARS-CoV-2-associated ARDS and discuss possible utility of cell therapies for its treatment, notably the use of reprogrammed macrophages with stable pro- or anti-inflammatory phenotypes.
['Kosyreva|Anna|A|', 'Dzhalilova|Dzhuliia|D|', 'Lokhonina|Anastasia|A|', 'Vishnyakova|Polina|P|', 'Fatkhudinov|Timur|T|']
D000086382:COVID-19 D064987:Cell- and Tissue-Based Therapy D006801:Humans D007249:Inflammation D008168:Lung D008262:Macrophage Activation D008264:Macrophages D016676:Macrophages, Alveolar D009000:Monocytes D012128:Respiratory Distress Syndrome D000086402:SARS-CoV-2
ARDS cells therapy M1/M2 macrophages SARS-CoV-2 inflammation