Subclinical carotid atherosclerosis and hyperuricemia in relation to renal impairment in a rural Japanese population: the Nagasaki Islands study.
OBJECTIVE
The influence of hyperuricemia on atherosclerosis is controversial. Subclinical carotid atherosclerosis can be defined in two ways in terms of mean and maximum carotid intima-media thickness (CIMT): one with mean CIMT≥1.1 mm and the other with maximum CIMT≥1.1 mm. However, no studies have been reported of the association between hyperuricemia and subclinical carotid atherosclerosis while taking the two different ways of classification into account.


METHODS
We conducted a cross-sectional study of 4133 subjects (1492 men and 2641 women) aged 30-89 years undergoing general health check-ups. For analysis of various associations, we calculated the multivariable odds ratios (ORs) for the two ways classifications of subclinical carotid atherosclerosis in relation to hyperuricemia.


RESULTS
Hyperuricemia-related renal impairment constitutes a significant marker for subclinical carotid atherosclerosis with mean CIMT≥1.1 mm for both men and women, while hyperuricemia per se was found to be beneficially associated with risk of subclinical carotid atherosclerosis with maximum CIMT≥1.1 mm for men. The classical cardiovascular risk factors without adjustment for glomerular filtration rate (GFR) of ORs for subclinical carotid atherosclerosis (mean CIMT≥1.1 mm) and subclinical carotid atherosclerosis (maximum CIMT≥1.1 mm) were 2.20(1.10-4.22) and 0.84(0.63-1.13) for men and 2.12(1.02-4.38) and 0.92(0.66-1.27) for women. After further adjustment for GFR, the corresponding values were 1.54(0.74-3.20) and 0.67(0.49-0.92) for men and 1.32(0.61-2.88) and 0.80(0.57-1.12) for women.


CONCLUSION
Hyperuricemia-related renal impairment is a significant marker for subclinical carotid atherosclerosis for both men and women, while hyperuricemia per se may be inversely associated with subclinical carotid atherosclerosis for men as seen in a rural community-dwelling Japanese population.
['Shimizu|Yuji|Y|', 'Sato|Shimpei|S|', 'Koyamatsu|Jun|J|', 'Yamanashi|Hirotomo|H|', 'Tamai|Mami|M|', 'Kadota|Koichiro|K|', 'Arima|Kazuhiko|K|', 'Yamasaki|Hironori|H|', 'Takamura|Noboru|N|', 'Aoyagi|Kiyoshi|K|', 'Maeda|Takahiro|T|']
D000328:Adult D000367:Age Factors D000368:Aged D000369:Aged, 80 and over D000428:Alcohol Drinking D058070:Asymptomatic Diseases D050197:Atherosclerosis D001786:Blood Glucose D015992:Body Mass Index D002340:Carotid Artery Diseases D015986:Confounding Factors, Epidemiologic D003404:Creatinine D003430:Cross-Sectional Studies D005260:Female D005919:Glomerular Filtration Rate D006801:Humans D033461:Hyperuricemia D007564:Japan D007668:Kidney D007674:Kidney Diseases D008055:Lipids D008297:Male D008875:Middle Aged D012307:Risk Factors D012424:Rural Population D012737:Sex Factors D012907:Smoking
Hyperuricemia CIMT Cross-sectional study