lncRNA expression predicts mRNA abundance.
Aim: Long noncoding RNAs (lncRNAs) have been reported to influence multiple gene regulatory processes. Technological advances in RNA-seq platforms allow detection of low-abundance RNA species such as lncRNAs. This study examined the relationship between expression of lncRNAs and their putative partner mRNAs. Methods: We analyzed total RNA-seq data from mouse macrophages under various inflammatory and intervention conditions. Results: The macrophage expression of lncRNAs is strongly regulated by an inflammatory stimulus. Moreover, the expression of a majority of lncRNAs was correlated or anti-correlated with the partner mRNA(s), across the different treatment conditions. This relationship was maintained even in cells from a distinct genotype. Conclusion: These results suggest a previously unappreciated tight coupling of lncRNA and mRNA expression during macrophage responses to various microenvironmental perturbations.
['Pacholewska|Alicja|A|0000-0002-4888-4883', 'Sung|Myong-Hee|MH|0000-0002-9739-8558']
D000818:Animals D020869:Gene Expression Profiling D005786:Gene Expression Regulation D053263:Gene Regulatory Networks D007249:Inflammation D008070:Lipopolysaccharides D008264:Macrophages D051379:Mice D062085:RNA, Long Noncoding D012333:RNA, Messenger
bioinformatics computational biology computational epigenomics functional genomics gene regulation