The effect of diagnostic hysteroscopy performed before fresh and frozen-thawed embryo transfer in IVF cycles on reproductive outcomes
Objective
Hysteroscopy is frequently performed in infertile women and thought to improve pregnancy rates. The data obtained from studies investigating the effect of hysteroscopy in in-vitro fertilization (IVF) cycles is variable. We aimed to evaluate the effect of hysteroscopy on pregnancy outcomes of fresh and frozen-thawed embryo transfers (FET) performed during IVF cycles.


Material and Methods
The data of the 765 patients, who had IVF treatment between January 2015 and July 2017 in an infertility center, were retrospectively analyzed. Of those, 586 (76.6%) patients underwent fresh embryo transfer, while 179 (23.4%) patients underwent FET. Hysteroscopy performed by a single experienced surgeon was scheduled two months before transfer. Hysteroscopy was performed in 101/586 (17.2%) in those undergoing fresh embryo transfer and 44/179 (24.6%) patients in the FET group. Pregnancy outcomes of the groups were compared respectively within their own group.


Results
The mean age was similar in patients in the fresh and FET groups (p=0.365, respectively). There was no difference in the number of transferred embryos between the groups (p=0.218). In the fresh embryo group there were 246 pregnancies, of which 44 had undergone diagnostic hysteroscopy while 202 had not, (p=0.516) and 79 pregnancies in the FET group, of which 20 had undergone diagnostic hysteroscopy while 59 had not (p=0.711). There was no statistical difference according to pregnancy rate between the groups (p=0.538).


Conclusion
Performing diagnostic hysteroscopy before fresh or FET does not improve the pregnancy rates.
['Eserol|Fuat|F|0000-0002-6537-5255', 'Göksever Çelik|Hale|H|0000-0002-5162-3262', 'Aytan|Aslı Nehir|AN|0000-0003-0879-9163', 'Çelik|Ali|A|0000-0002-3526-3789', 'Çelik|Engin|E|0000-0001-7646-6091', 'Buyru|Faruk|F|0000-0001-7889-5121', 'Bastu|Ercan|E|0000-0003-0810-6195']
Diagnostic hysteroscopy frozen-thawed embryo transfer pregnancy rate in-vitro fertilization fresh embryo transfer uterine cavity