Oxymatrine prevents synovial inflammation and migration via blocking NF-κB activation in rheumatoid fibroblast-like synoviocytes.
The fibroblast-like synoviocytes (FLSs) has the aggressive phenotype, which is very important for cartilage destruction in rheumatoid arthritis (RA). To the pathology of RA, the increased FLSs migration, activation and proliferation are essential factors. Oxymatrine is a traditional Chinese herb, which is the extraction from the root of Sophora flavescens and regarded as quinolizidine alkaloid compounds and has been shown to inhibit inflammation, proliferation and migration in vitro or vivo. However, whether oxymatrine effects in the treatment of RA FLSs is undefined. In our study, the inhibition of oxymatrine in RA FLSs inflammation, proliferation and migration in RA FLS are evaluated. We found that oxymatrine decreased the IL-6 and IL-8 expression and the proliferation, migration and invasion of RA FLSs. We also evaluated the molecular mechanisms and we found the effect of oxymatrine on NF-κB activation. The results showed that oxymatrine inhibited the activity of NF-κB. And the treatment activity of oxymatrine on collagen-induced arthritis (CIA) was further explored by us. Thus, we conclude that oxymatrine may protect joint destruction of RA by inhibiting synoviocyte activation, migration, invasion, and proliferation.
['Liang|Jiang|J|', 'Chang|Boyang|B|', 'Huang|Mingcheng|M|', 'Huang|Weichen|W|', 'Ma|Wukai|W|', 'Liu|Yang|Y|', 'Tai|Wan|W|', 'Long|Yi|Y|', 'Lu|Yun|Y|']
D000328:Adult D000470:Alkaloids D000818:Animals D000893:Anti-Inflammatory Agents D001169:Arthritis, Experimental D001172:Arthritis, Rheumatoid D002465:Cell Movement D049109:Cell Proliferation D002478:Cells, Cultured D004365:Drugs, Chinese Herbal D005260:Female D005347:Fibroblasts D006801:Humans D007249:Inflammation D015850:Interleukin-6 D016209:Interleukin-8 D008297:Male D051379:Mice D008811:Mice, Inbred DBA D008875:Middle Aged D016328:NF-kappa B D011807:Quinolizines D015398:Signal Transduction D029909:Sophora D013583:Synovial Membrane D015533:Transcriptional Activation
Oxymatrine Inflammation Migration NF-κB Fibroblast-like synoviocytes