Physicochemical properties and antioxidant activity of α-tocopherol loaded nanoliposome's containing DHA and EPA.
The aim of this study was to prepare α-tocopherol loaded nanoliposomes as carriers of DHA and EPA and to investigate their physicochemical properties, such as peroxide value (PV), volatile compounds (VOCs), particle size, size distribution, zeta potential and morphology of the liposomes. The particle size of liposomes was in the range of 82.4-107.2nm. The highest extent of lipid oxidation was observed at 40°C for 90days, with the lowest PV and propanal levels for a nanoliposome formulation in comparison with the control sample. The zeta potential of the nanoliposomes was decreased during storage. No significant change in the PV and zeta potential of the liposome formulations with α-tocopherol was observed at 4°C after 90days (0.14meq/kg and -43.5mV, respectively). This study demonstrated that incorporation of α-tocopherol into liposomes contributes a significant antioxidant effect on DHA and EPA.
['Sahari|Mohammad Ali|MA|', 'Moghimi|Hamid Reza|HR|', 'Hadian|Zahra|Z|', 'Barzegar|Mohsen|M|', 'Mohammadi|Abdorreza|A|']
D000975:Antioxidants D002626:Chemistry, Pharmaceutical D004281:Docosahexaenoic Acids D015118:Eicosapentaenoic Acid D008081:Liposomes D053758:Nanoparticles D010084:Oxidation-Reduction D010316:Particle Size D024502:alpha-Tocopherol
α-Tocopherol Nanoliposome DHA EPA Peroxide value Volatile compounds Boron trifluoride- methanol (PubChem CID: 11062313) Dipalmitoyl phosphatidylcholine (PubChem CID: 160339) Docosahexaenoic acid (PubChem CID: 445580) Eicosapentaenoic acid (PubChem CID: 446284) Heptanal (PubChem CID: 8130) Hexanal (PubChem CID: 6184) Methyl paraben (PubChem CID: 7456) N-dodecane (PubChem CID: 8182) Octanal (PubChem CID: 454) Pentadecanoic acid (PubChem CID: 13849) Propanal (PubChem CID: 527) Propyl paraben (PubChem CID: 7175) Stability d-alpha-tocopherol (PubChem CID: 14985)