Dietary B Vitamins and Serum C-Reactive Protein in Persons With Human Immunodeficiency Virus Infection: The Positive Living With HIV (POLH) Study.
BACKGROUND
B vitamins may have beneficial roles in reducing inflammation; however, research on the role of B vitamins in inflammation among HIV-infected persons is lacking.


OBJECTIVE
This study assessed the association between B vitamins and serum C-reactive protein (CRP) concentrations in HIV-infected persons.


METHODS
A cross-sectional survey was conducted among 314 HIV-infected persons (180 men and 134 women) aged 18 to 60 years residing in the Kathmandu, Nepal. High-sensitive and regular serum CRP concentrations were measured by the latex agglutination nephelometry and latex agglutination turbidimetric method, respectively. Dietary intake was assessed using 2 nonconsecutive 24-hour dietary recalls. The relationships between B vitamins and serum CRP concentrations were assessed using multiple regression analysis.


RESULTS
The multivariate-adjusted geometric mean of serum CRP concentrations was significantly decreased with an increasing B vitamins intake across quartiles of niacin (P for trend = .007), pyridoxine (P for trend = .042), and cobalamin (P for trend = .037) in men. In men, the mean serum CRP concentrations in the highest quartiles of niacin, pyridoxine, and cobalamin were 63%, 38%, and 58%, respectively, lower than that in the lowest quartile. In women, the mean serum CRP concentrations in the highest quartiles of riboflavin (P for trend = .084) and pyridoxine (P for trend = .093) were 37% and 47%, respectively, lower than that in the lowest quartile.


CONCLUSION
High intake of niacin, pyridoxine, or cobalamin was independently associated with decreased serum CRP concentrations among HIV-infected men. Further prospective studies are warranted to confirm the role of B vitamins in inflammation among HIV-infected persons.
['Poudel-Tandukar|Kalpana|K|', 'Chandyo|Ram Krishna|RK|']
D000293:Adolescent D000328:Adult D002097:C-Reactive Protein D003430:Cross-Sectional Studies D005260:Female D015658:HIV Infections D006801:Humans D008137:Longitudinal Studies D008297:Male D008875:Middle Aged D009390:Nepal D014803:Vitamin B Complex D055815:Young Adult
B vitamins C-reactive protein HIV developing country dietary assessment