Voice Tremor in Parkinson's Disease: An Acoustic Study.
BACKGROUND
Voice tremor associated with Parkinson disease (PD) has not been characterized. Its relationship with voice disability and disease variables is unknown.


OBJECTIVES
This study aimed to evaluate voice tremor in people with PD (pwPD) and a matched control group using acoustic analysis, and to examine correlations with voice disability and disease variables.


METHODS
Acoustic voice tremor analysis was completed on 30 pwPD and 28 age-gender matched controls. Voice disability (Voice Handicap Index), and disease variables of disease duration, Activities of Daily Living (Unified Parkinson's Disease Rating Scale [UPDRS II]), and motor symptoms related to PD (UPDRS III) were examined for relationship with voice tremor measures.


RESULTS
Voice tremor was detected acoustically in pwPD and controls with similar frequency. PwPD had a statistically significantly higher rate of amplitude tremor (Hz) than controls (P = 0.001). Rate of amplitude tremor was negatively and significantly correlated with UPDRS III total score (rho -0.509). For pwPD, the magnitude and periodicity of acoustic tremor was higher than for controls without statistical significance. The magnitude of frequency tremor (Mftr%) was positively and significantly correlated with disease duration (rho 0.463). PwPD had higher Voice Handicap Index total, functional, emotional, and physical subscale scores than matched controls (P < 0.001). Voice disability did not correlate significantly with acoustic voice tremor measures.


CONCLUSION
Acoustic analysis enhances understanding of PD voice tremor characteristics, its pathophysiology, and its relationship with voice disability and disease symptomatology.
['Gillivan-Murphy|Patricia|P|', 'Miller|Nick|N|', 'Carding|Paul|P|']
D000162:Acoustics D000328:Adult D000368:Aged D016022:Case-Control Studies D004185:Disability Evaluation D006801:Humans D008297:Male D008875:Middle Aged D010300:Parkinson Disease D010699:Phonation D011237:Predictive Value of Tests D011446:Prospective Studies D013068:Speech Production Measurement D014827:Vocal Cords D014832:Voice Disorders D014833:Voice Quality
Voice tremor Parkinson disease Voice disability Disease variables Acoustic analysis