Comprehensive analysis of aberrantly expressed profiles of messenger RNA in alcoholic liver disease.
BACKGROUND
Alcoholic liver disease (ALD) is one of the major cause of morbidity and mortality of clinical liver disease worldwide. Until today, although many general therapies are carried out and several molecular targets have been proposed to act as the potential therapeutic targets, more accurate molecular targets and more effective therapeutic methods remain needed.


MATERIAL AND METHODS
In the study, we analyze the differential expression genes (DEGs) between the patients with ALD and healthy controls. Gene Ontology enrichment and KEGG signaling pathway analysis are performed to identify the function of DEGs. Some significant molecules are proposed to act as the potential therapeutic targets for ALD. RNA data of 15 ALD tissues and 7 normal tissues for RNA expression analysis were obtained. DEGs in ALD samples compared with normal tissues identified through the limma R package and subjected to network analysis.


RESULTS
As a result, we obtained a total of 274 DEGs that mainly involved in biological processes related to the angiogenesis, stress reaction, synthesis, and metabolism of organic acids. Network analysis obtained several genes with high network degree and fold change. Some significant molecules are proposed to act as the potential therapeutic targets for ALD.


CONCLUSIONS
Our research identified some new progression-related genes of alcohol liver diseases, which could be regarded as the new targets for the early diagnosis and therapeutic management in ALD.
['Sun|Jinhui|J|0000-0002-0995-1748', 'Li|Baolong|B|', 'Sun|Antao|A|', 'Zhao|Kunpeng|K|', 'Ma|Yanchun|Y|', 'Zhao|Jiuli|J|', 'Pan|Hui|H|', 'Song|Qingrui|Q|', 'Wang|Yan|Y|', 'Yu|Chunyu|C|', 'Wang|Cui|C|', 'Zhang|Huan|H|', 'Zhang|Wenwen|W|', 'Kong|Chenfan|C|']
D019295:Computational Biology D030541:Databases, Genetic D020869:Gene Expression Profiling D053263:Gene Regulatory Networks D006801:Humans D008108:Liver Diseases, Alcoholic D012333:RNA, Messenger D015398:Signal Transduction D059467:Transcriptome
Alcoholic liver disease (ALD) differential expression genes (DEGs) network Gene Expression Omnibus (GEO)