Dormancy models for Mycobacterium tuberculosis: A minireview.
Dormancy models for Mycobacterium tuberculosis play important roles in understanding various aspects of tuberculosis pathogenesis and in the testing of novel therapeutic regimens. By simulating the latent tuberculosis infection, in which the bacteria exist in a non-replicative state, the models demonstrate reduced susceptibility to antimycobacterial agents. This minireview outlines the models available for simulating latent tuberculosis both in vitro and in several animal species. Additionally, this minireview discusses the advantages and disadvantages of these models for investigating the bacterial subpopulations and susceptibilities to sterilization by various antituberculosis drugs.
['Alnimr|Amani M|AM|']
D000818:Animals D000995:Antitubercular Agents D004195:Disease Models, Animal D024881:Drug Resistance, Bacterial D006168:Guinea Pigs D007202:Indicators and Reagents D055985:Latent Tuberculosis D008252:Macaca fascicularis D051379:Mice D009169:Mycobacterium tuberculosis D010078:Oxazines D011817:Rabbits D014397:Tuberculosis, Pulmonary D014966:Xanthenes D015027:Zebrafish
dormancy tuberculosis latency stationary-phase