Opioid-Induced Adaptations of cAMP Dynamics in the Nucleus Accumbens.
To investigate how opioid exposure alters dopamine (DA) responses in medium spiny neurons (MSNs), Muntean et al. used a novel cAMP sensor to track cAMP dynamics and report a coordinated effort of adaptations in D1- and D2-MSNs to integrate DA inputs and shift signaling strengths in various states of opioid dependence.
['Zych|Sarah|S|', 'Ford|Christopher P|CP|']
D000701:Analgesics, Opioid D003342:Corpus Striatum D009714:Nucleus Accumbens D017447:Receptors, Dopamine D1 D017448:Receptors, Dopamine D2
opioid dopamine GPCR striatum striosome