Derivatized Carbon Nanotubes for Gene Therapy in Mammalian and Plant Cells.
The concept of gene vectors for therapeutic applications has been known for several years, but it is far from revealing its actual potential. With the advent of hollow cylindrical carbon nanomaterials such as carbon nanotubes (CNTs), researchers have invented several new tools to deliver genes at the required site of action in mammalian and plant cells. The ease of diversified functionalization has allowed CNTs to be by far the most adaptable non-viral vector for gene therapy. This Minireview addresses the dexterity with which CNTs undergo surface modifications and their applications as a potent vector in gene therapy of humans and plants. Specifically, we will discuss the new tools that scientific communities have invented to achieve gene therapy using plasmid DNA, RNA silencing, suicide gene therapy, and plant genetic engineering. Additionally, we will shed some light on the mechanism of gene transportation using carbon nanotubes in cancer cells and plants.
['Singh|Adhish|A|', 'Hua Hsu|Ming|M|', 'Gupta|Neeraj|N|', 'Khanra|Partha|P|', 'Kumar|Pankaj|P|', 'Prakash Verma|Ved|V|', 'Kapoor|Mohit|M|0000-0003-4138-3733']
D000818:Animals D002460:Cell Line D002463:Cell Membrane Permeability D002470:Cell Survival D018014:Gene Transfer Techniques D015316:Genetic Therapy D005822:Genetic Vectors D015658:HIV Infections D006801:Humans D037742:Nanotubes, Carbon D009369:Neoplasms D059828:Plant Cells D010944:Plants D010957:Plasmids D034622:RNA Interference D013499:Surface Properties
carbon nanotubes gene therapy therapeutics delivery systems nanotechnology