Synthetic Methods of Quinoline Derivatives as Potent Anticancer Agents.
BACKGROUND
On account of significant biological activities, quinoline derivatives have drawn more attention to the synthesis and biological activities in the search for new therapeutic agents. Several new synthetic approaches have been implemented to derive new molecules from quinoline and all the synthesized molecules showed effective anticancer activity.


METHOD
Some molecules are synthesized using quinolones as precursor reactant, which is another effective product of quinoline, also showing significant activity against malignant tumors. The presence of nitrogen in it and its ability to bind with enzymes like gyrase, topoisomerase II and kinase have also proven it with antitumor activity.


CONCLUSION
This review encapsulates the recent advances in the synthesis and anticancer activity of Quinoline derivatives.
['Sharma|Vaibhav|V|', 'Mehta|Dinesh Kumar|DK|', 'Das|Rina|R|']
D000818:Animals D000970:Antineoplastic Agents D060326:Chemistry Techniques, Synthetic D015195:Drug Design D006801:Humans D009369:Neoplasms D011804:Quinolines
quinoline Anticancer anti-inflammatory cancer compounds heterocyclic tumour