The humanistic and economic burden of Dravet syndrome on caregivers and families: Implications for future research.
We reviewed the current literature with respect to the humanistic and financial burdens of Dravet Syndrome (DS) on the caregivers of children with DS, in order to (1) identify key unanswered questions or gaps in knowledge that need to be addressed and then, based on these knowledge gaps, (2) propose a research agenda for the scientific community to address in the coming decade. The findings support the conclusion that caring for a child with DS is associated with significant humanistic burden and direct costs. However, due in part to the paucity of studies, as well as the lack of measures of specific burden domains, there remains much that is not known regarding the burden of caregiving for children with DS. To address the significant knowledge gaps in this area, research is needed that will: (1) identify the specific domains of caregivers' lives that are impacted by caring for a child with DS; (2) identify or, if needed, develop measures of caregiving impact in this area; (3) identify the factors that influence DS caregiving burden; (4) develop and evaluate the efficacy of treatments for reducing the negative impact of DS and its comorbidities on DS caregivers; (5) quantify the direct medical costs associated with DS and DS comorbidities and identify the factors that influence these costs; and (6) quantify and fully explore the indirect costs of DS. Research that addresses these goals will provide the empirical foundation needed for improving the quality of life of children with DS and their families.
['Jensen|Mark P|MP|', 'Brunklaus|Andreas|A|', 'Dorris|Liam|L|', 'Zuberi|Sameer M|SM|', 'Knupp|Kelly G|KG|', 'Galer|Bradley S|BS|', 'Gammaitoni|Arnold R|AR|']
D035843:Biomedical Research D017028:Caregivers D002648:Child D017281:Cost of Illness D004831:Epilepsies, Myoclonic D005190:Family D005544:Forecasting D006801:Humans D011788:Quality of Life
Dravet syndrome Costs Caregiver burden Severe myoclonic epilepsy in infancy