MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6).
Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. Our findings suggest that miR-361-5p is a suppressor in CRPC. Signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. Therefore, miR-361-5p has great clinical significance in preventing the malignant progression of PCa.
['Liu|Dachuang|D|', 'Tao|Tao|T|', 'Xu|Bin|B|', 'Chen|Shuqiu|S|', 'Liu|Chunhui|C|', 'Zhang|Lei|L|', 'Lu|Kai|K|', 'Huang|Yeqing|Y|', 'Jiang|Liang|L|', 'Zhang|Xiaowen|X|', 'Huang|Xiaoming|X|', 'Zhang|Lihua|L|', 'Han|Conghui|C|', 'Chen|Ming|M|']
D020413:3' Untranslated Regions D000818:Animals D015153:Blotting, Western D045744:Cell Line, Tumor D049109:Cell Proliferation D020869:Gene Expression Profiling D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008297:Male D051379:Mice D008807:Mice, Inbred BALB C D008819:Mice, Nude D035683:MicroRNAs D009154:Mutation D020411:Oligonucleotide Array Sequence Analysis D011471:Prostatic Neoplasms D064129:Prostatic Neoplasms, Castration-Resistant D034622:RNA Interference D020133:Reverse Transcriptase Polymerase Chain Reaction D050800:STAT6 Transcription Factor D025521:Tumor Suppressor Proteins D023041:Xenograft Model Antitumor Assays D051020:bcl-X Protein
miR-361-5p Castration-resistant prostate cancer (CRPC) STAT6 Bcl-xL