Effects of diffusion on high-resolution quantitative T2 MRI.
Carr-Purcell-Meiboom-Gill-based sequences are often assumed to be insensitive to diffusion. However, imaging gradients always contribute some degree of diffusion weighting which increases with resolution. This may cause an apparent decrease in T2 when using a multi-echo sequence, such as quantitative T2 (qT2) at high resolution. This study investigated the impact of diffusion on the qT2 sequence. An equation was developed relating the diffusion factor associated with each echo (bqT2 ) to the underestimation of T2 , which was strongly dependent on both the actual T2 and the apparent diffusion coefficient of the tissue. The diffusion dependence of the measured T2 was demonstrated in rat spinal cord. The measured T2 was independent of the imaging plane in gray matter, where diffusion was isotropic, and orientation dependent in white matter, where diffusion was strongly anisotropic. The dependence of the measured T2 on the actual T2 value was also demonstrated in MnCl2 phantoms. The relationship between the resolution and underestimation of T2 was investigated both theoretically and experimentally for the original readout and a fully refocused readout. The fully refocused readout increased the resolution at which diffusion effects could be neglected whilst measuring T2 . To avoid the misidentification of cerebrospinal fluid when applying qT2 in the brain or spinal cord, a minimum in-plane voxel dimension of 0.2 mm was suggested for the standard qT2 sequence and 0.1 mm for the refocused readout. Simulations of myelin water fraction measurement indicated that signal-to-noise ratio requirements were increased in the presence of diffusion. Finally, the use of decreasing spoiler gradients to attenuate stimulated echoes should be avoided, as it was found to distort the T2 distribution when the slice thickness was less than 1 mm.
['Oakden|Wendy|W|', 'Stanisz|Greg J|GJ|']
D000818:Animals D004058:Diffusion D008279:Magnetic Resonance Imaging D008297:Male D051381:Rats D017207:Rats, Sprague-Dawley D059629:Signal-To-Noise Ratio
Diffusion Quantitative T2 White Matter Myelin CPMG Relaxometry < Endogenous Contrast Methods < Methods and Engineering