'Pathway drug cocktail': targeting Ras signaling based on structural pathways.
Tumors bearing Ras mutations are notoriously difficult to treat. Drug combinations targeting the Ras protein or its pathway have also not met with success. 'Pathway drug cocktails', which are combinations aiming at parallel pathways, appear more promising; however, to be usefully exploited, a repertoire of classified pathway combinations is desirable. This challenge would be facilitated by the availability of the structural network of signaling pathways. When integrated with functional and systems level clinical data, they can be powerful in advancing novel therapeutic platforms. Based on structural knowledge, drug cocktails may tear into multiple cellular processes that drive tumorigenesis, and help in deciphering the interrelationship between Ras mutations and the rewired Ras network. The pathway drug cocktail paradigm can be applied to other signaling protein targets.
['Nussinov|Ruth|R|', 'Tsai|Chung-Jung|CJ|', 'Mattos|Carla|C|']
D000818:Animals D000971:Antineoplastic Combined Chemotherapy Protocols D004359:Drug Therapy, Combination D006801:Humans D009369:Neoplasms D015398:Signal Transduction D018631:ras Proteins
structures parallel pathways cancer classification drug discovery oncogenic mutations