Impaired white-matter integrity in photosensitive epilepsy: a DTI study using tract-based spatial statistics.
BACKGROUND AND PURPOSE
The present study was designed to map alterations in brain white-matter in photosensitive epilepsy (PSE) by applying tract-based spatial statistics (TBSS) analysis.


METHODS
Diffusion tensor-imaging (DTI) data from MRI brain scans were collected from eight PSE patients and 16 gender- and age-matched non-epileptic controls using a SIEMENS Trio 3.0-Tesla scanner. For the white-matter analysis, DTI scans were processed using FSL software (http://www.fmrib.ox.ac.uk/fsl/index.html). Fractional anisotropy (FA) values in the PSE and control groups were compared using TBSS analysis corrected for multiple comparisons using threshold-free cluster enhancement.


RESULTS
Compared with the control subjects, the corpus callosum of PSE patients had significantly lower FA values.


CONCLUSION
Our DTI study indicates that white-matter in the corpus callosum was abnormal in PSE patients, and that DTI methods can serve as useful non-invasive tools to evaluate white-matter changes in PSE patients.
['Du|Hanjian|H|', 'Xie|Bing|B|', 'Lu|Peigang|P|', 'Feng|Hua|H|', 'Wang|Jian|J|', 'Yuan|Shaoji|S|']
D000328:Adult D000465:Algorithms D003337:Corpus Callosum D003627:Data Interpretation, Statistical D056324:Diffusion Tensor Imaging D020195:Epilepsy, Reflex D005260:Female D006801:Humans D007089:Image Enhancement D007090:Image Interpretation, Computer-Assisted D008297:Male D010775:Photic Stimulation D015203:Reproducibility of Results D012680:Sensitivity and Specificity D066127:White Matter D055815:Young Adult
White-matter Photosensitive epilepsy DTI Tract-based spatial statistics