Mitochondrial calcium uniporter complex modulation in cancerogenesis.
Aberrations in mitochondrial Ca2+ homeostasis have been associated with different pathological conditions, including neurological defects, cardiovascular diseases, and, in the last years, cancer. With the recent molecular identification of the mitochondrial calcium uniporter (MCU) complex, the channel that allows Ca2+ accumulation into the mitochondrial matrix, alterations in the expression levels or functioning in one or more MCU complex members have been linked to different cancers and cancer-related phenotypes. In this review, we will analyze the role of the uniporter and mitochondrial Ca2+ derangements in modulating cancer cell sensitivity to death, invasiveness, and migratory capacity, as well as cancer progression in vivo. We will also discuss some critical points and contradictory results to highlight the consequence of MCU complex modulation in tumor development.
['Marchi|Saverio|S|', 'Vitto|Veronica Angela Maria|VAM|', 'Danese|Alberto|A|0000-0002-0833-9987', 'Wieckowski|Mariusz R|MR|', 'Giorgi|Carlotta|C|', 'Pinton|Paolo|P|']
D000818:Animals D002118:Calcium D015220:Calcium Channels D063646:Carcinogenesis D045744:Cell Line, Tumor D002465:Cell Movement D006706:Homeostasis D006801:Humans D008928:Mitochondria D008954:Models, Biological
calcium cancer Mitochondrial Calcium Uniporter (MCU) Mitochondria