Red cell exchange transfusion halts progressive proliferative sickle cell retinopathy in a teenaged patient with hemoglobin SC disease.
A male with sickle SC disease presented at age 8 years with proliferative sickle cell retinopathy (PSCR) and bilateral vitreous hemorrhage which spontaneously resolved, then recurred at 13 years of age. Despite conventional therapy with repeated pan-retinal photocoagulation and pars plana vitrectomy, he developed progressive PSCR and recurrent vitreous hemorrhage over the next 30 months. We describe the successful use of chronic red cell exchange transfusion (RCE) to preserve his vision and stabilize the retinopathy.
['McKinney|Christopher M|CM|', 'Siringo|Frank|F|', 'Olson|Jeffrey L|JL|', 'Capocelli|Kelly E|KE|', 'Ambruso|Daniel R|DR|', 'Nuss|Rachelle|R|']
D000293:Adolescent D002648:Child D017707:Erythrocyte Transfusion D006450:Hemoglobin SC Disease D006801:Humans D008297:Male D012164:Retinal Diseases D014823:Vitreous Hemorrhage
red cell exchange sickle cell retinopathy hemoglobin SC disease