Mitochondrial macro-haplogroup JT may play a protective role in ovarian ageing.
This study of 200 Caucasian women shows that the distribution of the mtDNA macro-haplogroups in patients with diminished ovarian reserve (DOR) differed significantly from that of patients with normal ovarian reserve (NOR) (p=0.02). The JT macro-haplogroup was significantly under-represented in DOR patients compared with NOR patients (p=0.006) and compared with the estimated frequency of 18.8% in the general French population (p=0.0012). Our findings suggest that the risk of a prematurely depleted ovarian reserve would be three times lower for patients carrying the JT macro-haplogroup than for patients with any of the other mtDNA haplogroups (odds ratio: 0.3; 95% CI: 0.13-0.74). If these preliminary results are confirmed in larger independent studies, they should lead to the better management of infertility.
['May-Panloup|P|P|', 'Desquiret|V|V|', 'Morinière|C|C|', "Ferré-L'Hôtellier|V|V|", 'Lemerle|S|S|', 'Boucret|L|L|', 'Lehais|S|S|', 'Chao de la Barca|J M|JM|', 'Descamps|P|P|', 'Procaccio|V|V|', 'Reynier|P|P|']
D000328:Adult D000375:Aging D005260:Female D006239:Haplotypes D006801:Humans D008928:Mitochondria D010053:Ovary D044465:Whites
Ovarian ageing Diminished ovarian reserve Mitochondrial DNA Mitochondrial haplogroups