LINC01128 resisted acute myeloid leukemia through regulating miR-4260/NR3C2.
Acute myeloid leukemia (AML) is a prevalent class of blood disease with a high occurrence rate and relapse rate. The role of dysregulated microRNAs (miRNAs) in AML is emerging. MiR-4260 was identified to be a carcinogenic miRNA in colorectal cancer, but never has it been reported in AML. We aimed to study the function and mechanism of miR-4260 in AML. The miR-4260 level was higher in AML cell lines than the normal cell lines. Inhibition of miR-4260 hindered proliferation and increased apoptosis of AML cells. Mechanistically, long intergenic non-protein coding RNA 1128 (LINC01128) competed with nuclear receptor subfamily 3 group C member 2 (NR3C2) for miR-4260 so as to upregulate NR3C2. We identified the reduced levels of LINC01128 and NR3C2 in AML and it was suggested through rescue assays that LINC01128 repressed AML progression through regulating miR-4260/NR3C2 axis. In conclusion, we firstly uncovered that LINC01128 resisted acute myeloid leukemia through regulating miR-4260/NR3C2, providing novel clues for the treatment improvement of AML.
['Li|Haixia|H|', 'Tian|Xuefei|X|', 'Wang|Paoqiu|P|', 'Hu|Jihong|J|', 'Qin|Rong|R|', 'Xu|Ronghua|R|', 'Liu|Kai|K|', 'Hao|Jingquan|J|', 'Tian|Nie|N|']
D017209:Apoptosis D057809:HEK293 Cells D018922:HL-60 Cells D006801:Humans D015470:Leukemia, Myeloid, Acute D062085:RNA, Long Noncoding D018161:Receptors, Mineralocorticoid D000074084:THP-1 Cells D014162:Transfection D020298:U937 Cells D015854:Up-Regulation
LINC01128 miR-4260 NR3C2 AML