Pattern Recognition Receptors and the Host Cell Death Molecular Machinery.
Pattern Recognition Receptors (PRRs) are proteins capable of recognizing molecules frequently found in pathogens (the so-called Pathogen-Associated Molecular Patterns-PAMPs), or molecules released by damaged cells (the Damage-Associated Molecular Patterns-DAMPs). They emerged phylogenetically prior to the appearance of the adaptive immunity and, therefore, are considered part of the innate immune system. Signals derived from the engagement of PRRs on the immune cells activate microbicidal and pro-inflammatory responses required to eliminate or, at least, to contain infectious agents. Molecularly controlled forms of cell death are also part of a very ancestral mechanism involved in key aspects of the physiology of multicellular organism, including the elimination of unwanted, damaged or infected cells. Interestingly, each form of cell death has its particular effect on inflammation and on the development of innate and adaptive immune responses. In this review article, we discuss some aspects of the molecular interplay between the cell death machinery and signals initiated by the activation of PRRs by PAMPs and DAMPs.
['Amarante-Mendes|Gustavo P|GP|', 'Adjemian|Sandy|S|', 'Branco|Laura Migliari|LM|', 'Zanetti|Larissa C|LC|', 'Weinlich|Ricardo|R|', 'Bortoluci|Karina R|KR|']
D000818:Animals D017209:Apoptosis D016923:Cell Death D054884:Host-Pathogen Interactions D006801:Humans D007249:Inflammation D000069452:Pathogen-Associated Molecular Pattern Molecules D000069292:Pyroptosis D051192:Receptors, Pattern Recognition
PRR inflammation apoptosis necroptosis pathogen recognition receptor pyroptosis