Reactogenicity and immunogenicity of measles-rubella combined vaccine in school-entry-aged subjects with naturally acquired measles immunity.
BACKGROUND
The reintroduction of measles-rubella combined (MR) vaccination to Japan raised concerns about adverse events as well as immunogenicity related to booster immunization in subjects with naturally acquired immunity to measles or rubella.


METHODS
The time course of reactogenicity and antibody responses in recipients with pre-existing immunity to measles through natural infection was observed. Eighteen children aged 80-104 months received MR booster vaccination; 16 of them had had previous rubella vaccination.


RESULTS
There were virtually no clinical reactions related to booster vaccination, and a highly significant antibody response to rubella antigen, whereas the antibody rise to measles was statistically significant but poor.


CONCLUSIONS
Vaccination of individuals already immune is not harmful. Booster immunization to rubella for Japanese children is vitally important.
['Kumagai|Takuji|T|', 'Ihara|Toshiaki|T|', 'Nakayama|Tetsuo|T|', 'Nagata|Nobuo|N|', 'Kamiya|Hitoshi|H|']
D000888:Antibodies, Anti-Idiotypic D002648:Child D004797:Enzyme-Linked Immunosorbent Assay D005260:Female D006801:Humans D007113:Immunity, Innate D007074:Immunoglobulin G D015994:Incidence D007564:Japan D008297:Male D008457:Measles D022542:Measles-Mumps-Rubella Vaccine D009107:Mumps D012189:Retrospective Studies D012409:Rubella D012574:Schools D014611:Vaccination
reactogenicity measles-rubella combined vaccine antibody