MCPIP1/Regnase-1 Expression in Keratinocytes of Patients with Hidradenitis Suppurativa: Preliminary Results.
The pathogenesis of hidradenitis suppurativa (HS) is yet to be fully understood. However, inflammation is a key element in the development of skin lesions. The aim of this study was to evaluate the expression of monocyte chemotactic protein-1-induced protein-1 (MCPIP1) in the skin of patients suffering from HS. Skin biopsies of 15 patients with HS and 15 healthy controls were obtained and processed for immunohistochemistry, western blot, and real time PCR. The highest mean MCPIP1 mRNA expression was found in the inflammatory lesional skin of HS patients. It was significantly higher than MCPIP1 mRNA expression in the biopsies from both healthy controls and non-lesional skin of HS patients. Western blot analysis indicated that expression of MCPIP1 was elevated within both lesional and non-lesional skin compared to the healthy control. The increased MCPIP1 mRNA and protein expression level in HS lesions may indicate its possible role in the disease pathogenesis.
['Krajewski|Piotr K|PK|0000-0003-4722-8531', 'Szukała|Weronika|W|0000-0003-1346-2418', 'Lichawska-Cieślar|Agata|A|', 'Matusiak|Łukasz|Ł|', 'Jura|Jolanta|J|0000-0002-0816-3475', 'Szepietowski|Jacek C|JC|0000-0003-0766-6342']
D000328:Adult D016022:Case-Control Studies D005260:Female D017497:Hidradenitis Suppurativa D006801:Humans D007150:Immunohistochemistry D007249:Inflammation D015603:Keratinocytes D008297:Male D012333:RNA, Messenger D012260:Ribonucleases D012867:Skin D014157:Transcription Factors
MCPIP1 Regnase-1 hidradenitis suppurativa