The protective role of jervine against radiation-induced gastrointestinal toxicity.
In this study, we investigated whether jervine (J) could prevent gastrointestinal (GI) side effects of abdominopelvic radiotherapy (RT) in Wistar-Albino female rats. Rats were divided into five groups: control (C), J only (J), J administered at 5 mg/kg/days for 7 days, RT only (RT), J before RT (J + RT), J administered for seven days before RT, J both before and after RT (J + RT + J), and J administered for 7 days before RT and after RT for 3 days. The weights of rats were measured on the 1st, 7th, and 10th days of the study. Rats were sacrificed to obtain tissues from the liver and intestine, which was followed by taking blood samples intracardially. In addition, the tissues were stained with pyruvate dehydrogenase (PDH) immunohistochemically. In our study, J supplementation markedly reduced weight loss, and histopathological, immunohistochemical, biochemical results suggest that J had a protective effect on GI toxicity following RT.
['Yakan|Selvinaz|S|http://orcid.org/0000-0002-6274-9012', 'Aydin|Tuba|T|http://orcid.org/0000-0002-7653-6480', 'Gulmez|Canan|C|http://orcid.org/0000-0003-3253-1407', 'Ozden|Ozkan|O|http://orcid.org/0000-0002-9467-3761', 'Eren Erdogan|Kivilcim|K|http://orcid.org/0000-0002-4951-8703', 'Daglioglu|Yusuf Kenan|YK|http://orcid.org/0000-0003-3140-2937', 'Andic|Fundagul|F|http://orcid.org/0000-0003-0943-6284', 'Atakisi|Onur|O|http://orcid.org/0000-0003-1183-6076', 'Cakir|Ahmet|A|http://orcid.org/0000-0003-1672-1438']
D000818:Animals D005765:Gastrointestinal Agents D011832:Radiation Injuries D051381:Rats D017208:Rats, Wistar D014704:Veratrum Alkaloids
jervine Radiotherapy pyruvate dehydrogenase (PDH)