Minimal-assumption inference from population-genomic data.
Samples of multiple complete genome sequences contain vast amounts of information about the evolutionary history of populations, much of it in the associations among polymorphisms at different loci. We introduce a method, Minimal-Assumption Genomic Inference of Coalescence (MAGIC), that reconstructs key features of the evolutionary history, including the distribution of coalescence times, by integrating information across genomic length scales without using an explicit model of coalescence or recombination, allowing it to analyze arbitrarily large samples without phasing while making no assumptions about ancestral structure, linked selection, or gene conversion. Using simulated data, we show that the performance of MAGIC is comparable to that of PSMC' even on single diploid samples generated with standard coalescent and recombination models. Applying MAGIC to a sample of human genomes reveals evidence of non-demographic factors driving coalescence.
['Weissman|Daniel B|DB|0000-0002-7799-1573', 'Hallatschek|Oskar|O|']
D019295:Computational Biology D019143:Evolution, Molecular D006801:Humans D056186:Metagenomics
inference genomics polymorphism coalescence recombination human evolutionary biology population genomics