Paromomycin sulfate is an effective treatment for balantidiasis in captive cynomolgus monkeys.
There are few effective antimicrobial agents against Balantidium coli infection. The effect of paromomycin sulfate (PS) against B. coli was confirmed in this study of 596 captive cynomolgus monkeys. In several trials, the minimum dose and duration of oral administration of PS were 25 mg/day for 5 + 5 days, with a 2-day withdrawal interval. To facilitate daily PS administration, pumpkin cakes supplemented with PS were made, which not only resulted in precise effects but also increased the efficiency of preparation and administration of PS by the animal care staff. No cysts or trophozoites were detected at 14 or 16 days after the last treatments. There were no obvious differences in blood and biochemical parameters between before and after administration of PS. These results indicate that PS is effective for elimination of B. coli without hematological side effects. These data could contribute to the control of microbiological pathogens during veterinary care and colony management in primate facilities.
['Nakamura|Shinichiro|S|', 'Itagaki|Iori|I|', 'Nakagawa|Takahiro|T|', 'Kawamoto|Ikuo|I|', 'Asano|Takahiro|T|', 'Arakawa|Daichi|D|', 'Tsuchiya|Hideaki|H|']
D000818:Animals D000981:Antiprotozoal Agents D001447:Balantidiasis D001448:Balantidium D005243:Feces D005260:Female D008252:Macaca fascicularis D008297:Male D008992:Monkey Diseases D010303:Paromomycin
paromomycin sulfate cynomolgus monkey Balantidium coli