Objective assessment of clinical, oncological and cosmetic outcomes following volume replacement in patients undergoing oncoplastic breast-conserving surgery: protocol for a systematic review.
INTRODUCTION
Oncoplastic breast surgery allows the excision of larger tumours without compromising cosmetic outcome and can be broadly divided into volume displacement and volume replacement techniques. Although oncoplastic surgery has rapidly gained acceptance and is now widely practised, evidence is still lacking especially in patients who underwent volume replacement techniques. As it is a relatively new technique that has been described in the literature in the recent years, a summary of evidence from this literature can help clinicians to understand the clinical, oncologicalandcosmetic outcomes of such procedures.


METHODS AND ANALYSIS
All original studies including randomised controlled trials, cohort studies, case-control studies and case series involving more than 10 women undergoing partial breast reconstruction using a volume replacement technique will be included. The primary objective is to evaluate the clinical, oncological and cosmetic outcomes following volume replacement in patients undergoing oncoplastic breast-conserving surgery. The secondary objective is to review the patient-reported outcomes (PROMs) associated with oncoplastic breast surgery to help identify any unmet needs and to consider refining the existing PROMs to suit women undergoing volume replacement surgery.A comprehensive literature search, eligibility assessment and extraction of data will be conducted by two trained teams acting independently. Data will be extracted and stored in a database with standardised extraction fields to facilitate easy and consistent data entry. Heterogeneity will be assessed using the Cochrane tests.


ETHICS AND DISSEMINATION
This systematic review requires no ethical approval. It will be published in a peer-reviewed journal, and it will also be presented at nationalandinternational conferences.


PROSPERO REGISTRATION NUMBER
CRD42017075700; Pre-results.
['Hu|Jesse|J|', 'Rainsbury|Richard M|RM|', 'Segaran|Ashvina|A|', 'Predescu|Oana|O|', 'Roy|Pankaj G|PG|']
D001943:Breast Neoplasms D004954:Esthetics D005260:Female D006801:Humans D016462:Mammaplasty D015412:Mastectomy, Segmental D000071066:Patient Reported Outcome Measures D012107:Research Design D000078202:Systematic Reviews as Topic D016896:Treatment Outcome
oncoplastic partial breast reconstruction breast cancer breast conserving surgery