Janus Iron Oxides @ Semiconducting Polymer Nanoparticle Tracer for Cell Tracking by Magnetic Particle Imaging.
Iron oxides nanoparticles tailored for magnetic particle imaging (MPI) have been synthesized, and their MPI signal intensity is three-times that of commercial MPI contrast (Ferucarbotran, also called Vivotrax) and seven-times that of MRI contrast (Feraheme) at the same Fe concentration. MPI tailored iron oxide nanoparticles were encapsulated with semiconducting polymers to produce Janus nanoparticles that possessed optical and magnetic properties for MPI and fluorescence imaging. Janus particles were applied to cancer cell labeling and in vivo tracking, and as few as 250 cells were imaged by MPI after implantation, corresponding to an amount of 7.8 ng of Fe. Comparison with MRI and fluorescence imaging further demonstrated the advantages of our Janus particles for MPI-super sensitivity, unlimited tissue penetration, and linear quantitativity.
['Song|Guosheng|G|', 'Chen|Min|M|', 'Zhang|Yanrong|Y|', 'Cui|Liyang|L|', 'Qu|Haibo|H|', 'Zheng|Xianchuang|X|', 'Wintermark|Max|M|', 'Liu|Zhuang|Z|0000-0002-1629-1039', 'Rao|Jianghong|J|']
D000818:Animals D058948:Cell Tracking D003287:Contrast Media D005290:Ferric Compounds D006367:HeLa Cells D006801:Humans D008279:Magnetic Resonance Imaging D008280:Magnetics D051379:Mice D053758:Nanoparticles D009369:Neoplasms D061848:Optical Imaging D011108:Polymers D012666:Semiconductors D051598:Whole Body Imaging
iron oxides semiconducting polymer cell tracking magnetic particle imaging