Efficacy of Surgery and Further Treatment of Progressive Glioblastoma.
BACKGROUND
Treatment options for patients with glioblastoma at progression have remained controversial, and selection criteria for the appropriate type of intervention remain poorly defined. The objectives were to determine which factors favor the decision for second surgery and which factors are associated with overall survival (OS) and to evaluate the National Institutes of Health (NIH) recurrent glioblastoma scale. The scale includes tumor involvement of eloquent brain regions, functional status, and tumor volume.


METHODS
A retrospective single-center analysis of patients with newly diagnosed glioblastoma undergoing initial surgery between January 2007 and December 2011 was performed. Patients were separated into two groups: those with versus those without second resection surgery at disease progression. OS was compared using the multiple logistic regression model, Cox proportional hazard regression, and Kaplan-Meier survival analysis.


RESULTS
The data of 98 patients were statistically analyzed. Among the patients, 58 had initial surgery only (age 61.27 years; median OS [mOS] 14.81 months) and 40 underwent second surgery at disease progression (age 55 years; mOS 18.86 months). Age was the only predictor for repeated surgery (P = 0.012; odds ratio 0.94). At the time of tumor progression, administration of alkylating chemotherapy (P = 0.004; hazard ratio [HR] 0.24) or bevacizumab (P = 0.001; HR 0.23) was associated with longer OS. Reoperation was associated with a lower HR (P = 0.134; HR 0.66). The NIH recurrent glioblastoma scale showed statistically significant improvement of prognosis prediction with the addition of age.


CONCLUSIONS
Surgery of progressive glioblastoma and postoperative treatment at the time of progression is associated with improved OS in some patients. The addition of age may improve survival prediction of the NIH recurrent glioblastoma scale.
['Woernle|Christoph Michael|CM|', 'Péus|Dominik|D|', 'Hofer|Silvia|S|', 'Rushing|Elisabeth Jane|EJ|', 'Held|Ulrike|U|', 'Bozinov|Oliver|O|', 'Krayenbühl|Niklaus|N|', 'Weller|Michael|M|', 'Regli|Luca|L|']
D000367:Age Factors D000368:Aged D001932:Brain Neoplasms D005260:Female D005909:Glioblastoma D006801:Humans D016015:Logistic Models D008297:Male D008875:Middle Aged D012086:Reoperation D012189:Retrospective Studies D016019:Survival Analysis D015996:Survival Rate D016896:Treatment Outcome D047368:Tumor Burden
Glioblastoma Recurrence Bevacizumab Neurosurgery Prognostic score Temozolomide