Frailty in end-stage hip or knee osteoarthritis: validation of the Groningen Frailty Indicator (GFI) questionnaire.
Frailty is highly prevalent in the elderly, increasing the risk of poor health outcomes. The Groningen Frailty Indicator (GFI) is a 15-item validated questionnaire for the elderly. Its value in patients with end-stage hip or knee osteoarthritis (OA) has not yet been determined. This study assesses the validity of the GFI in this patient group. End-stage hip or knee OA patients completed the GFI (range 0-15, ≥ 4 = frail) before arthroplasty surgery. Convergent validity was determined by Spearman-rank correlation between the SF-12 physical (PCS) and mental (MCS) component scores and the physical and mental GFI-domains, respectively. Discriminant validity was assessed by means of overall GFI-score and the pain-domain of the Hip/Knee Osteoarthritis Outcome Score (HOOS/KOOS). Altogether 3275 patients were included of whom 2957 (90.3%) completed the GFI. Mean GFI-scores were 2.78 (2.41) and 2.28 (1.99) in hip and knee OA-patients, respectively, with 570 (35.9%) of hip and 344 (24.1%) of knee patients considered frail. The convergent validity was moderate to strong (physical domain R = - 0.4, mental domain R = - 0.6) and discriminant validity low (R HOOS/KOOS-pain domain = - 0.2), confirming the validity of the GFI-questionnaire in this population. With 90% of participants completing the GFI, it is a feasible and valid questionnaire to assess frailty in end-stage hip and knee OA-patients. One-third (33.3%) of the patients undergoing hip arthroplasty and a quarter (24.1%) of those undergoing knee arthroplasty are frail. Whether this is associated with worse outcomes and can thus be used as a pre-operative predictor needs to be explored.
['Meessen|Jennifer M T A|JMTA|http://orcid.org/0000-0002-1744-6899', 'Leichtenberg|Claudia S|CS|http://orcid.org/0000-0002-4388-0963', 'Tilbury|Claire|C|http://orcid.org/0000-0002-2910-3391', 'Kaptein|Bart L|BL|http://orcid.org/0000-0001-8772-9985', 'Koster|Lennard A|LA|', 'Slagboom|P Eline|PE|http://orcid.org/0000-0002-2875-4723', 'Verdegaal|Suzan H M|SHM|http://orcid.org/0000-0002-3392-1100', 'Onstenk|Ron|R|http://orcid.org/0000-0001-5763-4125', 'van der Linden-van der Zwaag|Henrike M J|HMJ|', 'Kaptijn|Herman|H|', 'Vehmeijer|Stephan B W|SBW|', 'Marijnissen|Willem-Jan C|WC|', 'Damen|Pieter-Jan|PJ|', 'Nelissen|Rob G H H|RGHH|http://orcid.org/0000-0003-1228-4162', 'Vliet Vlieland|Thea P M|TPM|']
D000203:Activities of Daily Living D000367:Age Factors D000368:Aged D004185:Disability Evaluation D005240:Feasibility Studies D005260:Female D016330:Frail Elderly D000073496:Frailty D006304:Health Status D006801:Humans D008297:Male D008603:Mental Health D008875:Middle Aged D009426:Netherlands D015207:Osteoarthritis, Hip D020370:Osteoarthritis, Knee D010147:Pain Measurement D011237:Predictive Value of Tests D011379:Prognosis D011788:Quality of Life D015203:Reproducibility of Results D011795:Surveys and Questionnaires
Frailty Osteoarthritis Validation Groningen Frailty Indicator Arthroplasty