Review of non-invasive intracranial pressure measurement techniques for ophthalmology applications.
Assessment and monitoring of intracranial pressure (ICP) are important in the management of traumatic brain injury and other cerebral pathologies. In the eye, ICP elevation and depression both correlate with optic neuropathies, the former because of papilledema and the latter related to glaucoma. While the relationship between ICP elevation and papilledema is well established, the relationship between low ICP and glaucoma is still poorly understood. So far, ICP monitoring is performed invasively, but this entails risks including infection, spurring the study of non-invasive alternatives. We review 11 methods of non-invasive estimation of ICP including correlation to optic nerve sheath diameter, intraocular pressure, ophthalmodynamometry and two-depth transcranial Doppler of the ophthalmic artery. While none of these methods can fully replace invasive techniques, certain measures show great potential for specific applications. Although only used in small studies to date, a MRI based method known as MR-ICP, appears to be the best non-invasive technique for estimating ICP, with two-depth transcranial ultrasound and ophthalmodynamometry showing potential as well.
['Price|David Andrew|DA|', 'Grzybowski|Andrzej|A|0000-0002-3724-2391', 'Eikenberry|Jennifer|J|', 'Januleviciene|Ingrida|I|', 'Verticchio Vercellin|Alice Chandra|AC|', 'Mathew|Sunu|S|', 'Siesky|Brent|B|', 'Harris|Alon|A|0000-0001-8770-3726']
D001927:Brain Diseases D000070642:Brain Injuries, Traumatic D003941:Diagnostic Techniques, Ophthalmological D006801:Humans D007427:Intracranial Pressure D007429:Intraocular Pressure D008279:Magnetic Resonance Imaging D008991:Monitoring, Physiologic D009186:Myelin Sheath D009880:Ophthalmic Artery D009884:Ophthalmodynamometry D009900:Optic Nerve D011559:Pseudotumor Cerebri D017585:Ultrasonography, Doppler, Transcranial
glaucoma optic nerve intraocular pressure imaging