Cancer-associated fibroblasts of colorectal cancer and their markers: updates, challenges and translational outlook.
Accumulation of cancer-associated fibroblasts (CAFs) in the tumor microenvironment is associated with poor prognosis and recurrence of colorectal cancer (CRC). Despite their prominent roles in colorectal carcinogenesis, there is a lack of robust and specific markers to classify the heterogeneous and highly complex CAF populations. This has resulted in confusing and misleading definitions of CAFs in cancer niche. Advancements in molecular biology approaches have open doors to reliable CAF marker detection methods in various solid tumors. These discoveries would contribute to more efficient screening, monitoring and targeted therapy of CRC thus potentially will reduce cancer morbidity and mortality rates. This review highlights current scenarios, dilemma, translational potentials of CAF biomarker and future therapeutic applications involving CAF marker identification in CRC.
['Musa|Marahaini|M|https://orcid.org/0000-0002-0165-5741', 'Ali|Adli|A|https://orcid.org/0000-0001-5615-5966']
D000818:Animals D014408:Biomarkers, Tumor D000072645:Cancer-Associated Fibroblasts D015179:Colorectal Neoplasms D019468:Disease Management D004198:Disease Susceptibility D006801:Humans D007157:Immunologic Surveillance D025202:Molecular Diagnostic Techniques D058990:Molecular Targeted Therapy D014411:Neoplastic Stem Cells D009389:Neovascularization, Pathologic D011379:Prognosis D059016:Tumor Microenvironment
marker tumor microenvironment colon neoplasm tumor heterogeneity