Thymic inflammatory pseudotumor with multilocular thymic cyst caused by immunoglobulin G4-related disease.
A 44-year-old man was referred to our hospital after an anterior mediastinal tumor was noted on computed tomography during follow-up observation after left testicular seminoma resection. Chest computed tomography revealed an enhanced mass measuring 33 x 16 x 15 mm at the anterior mediastinum. Chest magnetic resonance imaging revealed high signal intensity on T2-weighted imaging, and F18  fluorodeoxyglucose-positron emission tomography showed a maximum standardized uptake of 12.45. Laboratory tests revealed no elevated tumor markers, except for mildly elevated interleukin-2. Based on these results, complete resection was performed under suspicion of a malignant tumor, mediastinal metastasis of seminoma, or malignant lymphoma. An extended thymectomy with partial merger pericardial resection was performed using a subxiphoid approach. Small nodules and multiple thymic cysts were observed the thymus in addition to the main mass. Microscopic examination of the tumor revealed fibrosis, lymphocyte infiltration with lymphoid follicular hyperplasia, and hyperplasia of the thymus. Numerous immunoglobulin G4 (IgG4)-positive plasma cells were found on immunohistochemical staining. The ratio of IgG4 to total IgG was approximately 60%. We ultimately diagnosed the patient with a thymic inflammatory pseudotumor with multilocular cyst caused by IgG4-related disease.
['Oda|Risa|R|', 'Okuda|Katsuhiro|K|0000-0003-0099-2348', 'Murase|Takayuki|T|', 'Watanabe|Takuya|T|', 'Sakane|Tadashi|T|', 'Tatematsu|Tsutomu|T|', 'Yokota|Keisuke|K|', 'Haneda|Hiroshi|H|', 'Nakanishi|Ryoichi|R|']
D000328:Adult D006104:Granuloma, Plasma Cell D006801:Humans D000077733:Immunoglobulin G4-Related Disease D007376:Interleukin-2 D008279:Magnetic Resonance Imaging D008297:Male D008476:Mediastinal Cyst D018239:Seminoma D013934:Thymectomy D014057:Tomography, X-Ray Computed
Anterior mediastinal tumor thymus immunoglobulin G4-related (IgG4- related) disease