Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines.
A series of twenty two novel 1-cyclopropyl-6-fluoro-4-oxo-7-(4-substituted piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid analogues have been synthesized, characterized ((1)H NMR, (13)C NMR and LCMS) and evaluated for their inhibitory activity on the proliferation of human caucasian acute lymphoblastic leukemia cells (CCRF-CEM), breast adenocarcinoma cells (MDA-MB-468) and human colon carcinoma cells (HCT-116). Among all the synthesized ciprofloxacin analogues 3t at 50 μM showed comparable potency to doxorubicin (10 μM) in all three cell lines and 3j inhibited proliferation of MDA-MB-468 up to 35% selectively over other two cell lines.
['Suresh|Narva|N|', 'Nagesh|Hunsur Nagendra|HN|', 'Sekhar|Kondapalli Venkata Gowri|KV|', 'Kumar|Anil|A|', 'Shirazi|Amir N|AN|', 'Parang|Keykavous|K|']
D000900:Anti-Bacterial Agents D000970:Antineoplastic Agents D045744:Cell Line, Tumor D002939:Ciprofloxacin D004354:Drug Screening Assays, Antitumor D024841:Fluoroquinolones D006801:Humans D015394:Molecular Structure D013329:Structure-Activity Relationship
Ciprofloxacin Anti-proliferative Anti-cancer Fluoroquinolones Substituted piperazines