Effect of XiangBin granules on post-operative gastrointestinal function and brain-gut peptides after transabdominal gynecological surgery.
OBJECTIVES
We conducted a prospective clinical randomized single-blind placebo-controlled trial (ChiCTR-TRC-14004156) to observe the effect of XiangBin granules on the recovery of gastrointestinal function and levels of brain-gut peptide motilin (MTL); vasoactive intestinal peptide (VIP); growth hormone releasing peptide-ghrelin, GHRP-ghrelin, and corticotropin releasing hormone (CRH), after transabdominal gynecological surgery.


STUDY DESIGN
Patients undergoing gynecologic abdominal surgery were randomly divided in a 2:1 ratio (according to the data of pre-trial which was a small sample randomized trial in gynecology inpatient) into two groups: the larger treatment group taking XiangBin granules, and the smaller placebo group taking Chinese herbal placebo. The aim was to observe anal exhaust time, time to defecation, and the change in level of brain-gut peptide.


RESULT
A significantly shorter time to first postoperative anal exhaust was observed in the treatment group. In the placebo group, the MTL level on the first day after surgery was lower than the preoperative level (P<0.05). In both groups, the GHRP-ghrelin level on the first postoperative day was lower than the preoperative level (P<0.05). In the treatment group, the GHRP-ghrelin level of the third day after surgery was higher than the first day after surgery (P<0.05). The CRH level on the first postoperative day was lower in the treatment group compared to the placebo group (P<0.05).


CONCLUSION
XiangBin granules can effectively promote the recovery of gastrointestinal function after surgery for gynecologic abdomen and promote GHRP-ghrelin and MTL recovery, and reduce the postoperative secretion of CRH.
['Wen|Si-Liang|SL|', 'Feng|Xian|X|', 'Chen|Zhi-Qiang|ZQ|', 'Xiao|Jing|J|', 'Zhang|Wei-Xuan|WX|']
D000005:Abdomen D000328:Adult D003346:Corticotropin-Releasing Hormone D003672:Defecation D004365:Drugs, Chinese Herbal D005260:Female D041981:Gastrointestinal Tract D054439:Ghrelin D013509:Gynecologic Surgical Procedures D006801:Humans D008875:Middle Aged D009037:Motilin D011184:Postoperative Period D016037:Single-Blind Method D016896:Treatment Outcome D014660:Vasoactive Intestinal Peptide D055815:Young Adult
XiangBin granules Gastrointestinal function Brain-gut peptides Transabdominal gynecological surgery