Punctal stenosis associated with dupilumab therapy for atopic dermatitis.
In this case series, the authors report three patients with severe atopic dermatitis who presented with epiphora and conjunctivitis while undergoing dupilumab therapy. On clinical examination, all patients were found to have punctal stenosis, with one case having progressed to punctal obstruction. An assortment of strategies was elected, including discontinuation of dupilumab, treatment of conjunctivitis, and surgical intervention with probing, punctoplasty, and silicone intubation. This report spotlights punctal stenosis as an important new side effect of dupilumab and suggests that additional cases of dupilumab-associated lacrimal drainage impairment will continue to emerge.
['Lee|Debora H|DH|0000-0002-5870-134X', 'Cohen|Liza M|LM|', 'Yoon|Michael K|MK|', 'Tao|Jeremiah P|JP|']
D061067:Antibodies, Monoclonal, Humanized D003251:Constriction, Pathologic D003608:Dacryocystorhinostomy D003876:Dermatitis, Atopic D006801:Humans D007440:Intubation D007767:Lacrimal Duct Obstruction D012189:Retrospective Studies
punctal stenosis Dupilumab atopic dermatitis conjunctivitis punctal obstruction