Effects of chronic administration of adipokinetic and hypertrehalosemic hormone on animal behavior, BDNF, and CREB expression in the hippocampus and neurogenesis in mice.
Neurosecretory cells in corpus cardiacum of insects synthesize a set of hormones that are called adipokinetic, hypertrehalosaemic or hyperprolinaemic, depending on insect in question. This study investigated effects of chronic administration of Anax imperator adipokinetic hormone (Ani-AKH), Libellula auripennis adipokinetic hormone (Lia-AKH), and Phormia-Terra hypertrehalosaemic hormone (Pht-HrTH) on depression, anxiety, analgesy, locomotion in forced swimming (FST), elevated plus-maze (EPM), hot plate, and locomotor activity tests. Ani-AKH (1 and 2 mg/kg), Lia-AKH (1 and 2 mg/kg), and Pht-HrTH (1 and 2 mg/kg) had antidepressant effects in forced swimming test. Lia-AKH (2 mg/kg) and Pht-HrTH (1 and 2 mg/kg) had anxiolytic effects when given chronically in elevated plus-maze test. Ani-AKH (1 and 2 mg/kg) and Pht-HrTH (2 mg/kg) had antinociceptive effects in hot plate test in male balb-c mice. Ani-AKH (2 mg/kg), Lia-AKH (1 and 2 mg/kg), and Pht-HrTH had locomotion-enhancing effects in locomotor activity test in male balb-c mice. Drug treatment significantly increased brain-derived neurotrophic factor (BDNF) and cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) gene expression levels compared to control levels. Pht-HrTH and Ani-AKH groups had significantly increased numbers of BrdU-labeled cells, while neurodegeneration was lower in the Pht-HrTH group. Our study showed that AKH/RPCH family peptides may be used in treatment of psychiatric illness such as depression and anxiety, in treatment of pain and in diseases related to locomotion system. AKH/RPCH family peptides increase neurotrophic factors in brain and have potential proliferative and neuroprotective effects in hippocampal neurogenesis and neurodegeneration.
['Mutlu|Oguz|O|', 'Gumuslu|Esen|E|', 'Kokturk|Sibel|S|', 'Ulak|Guner|G|', 'Akar|Furuzan|F|', 'Erden|Faruk|F|', 'Kaya|Havva|H|', 'Tanyeri|Pelin|P|']
D000700:Analgesics D000818:Animals D014151:Anti-Anxiety Agents D001522:Behavior, Animal D019208:Brain-Derived Neurotrophic Factor D017362:Cyclic AMP Response Element-Binding Protein D006624:Hippocampus D007301:Insect Hormones D018782:Maze Learning D008815:Mice, Inbred Strains D009043:Motor Activity D055495:Neurogenesis D009479:Neuropeptides D018696:Neuroprotective Agents D009842:Oligopeptides D011761:Pyrrolidonecarboxylic Acid D013550:Swimming
animal behavior neurogenesis mice adipokinetic hormone neurotrophic factors