Contrast-associated transient cortical blindness: three cases with MRI and electrophysiology findings.
Transient cortical blindness (TCB) is a rare but striking complication following contrast agent injection. TCB might be secondary to a direct toxicity of the contrast agent, leading to an osmotic disruption of the blood-brain barrier (BBB), with a preferential involvement of the posterior circulation and occipital cortex. We report a series of three patients with contrast medium-associated TCB (intra-arterial injection of non-ionic contrast agent during diagnostic cerebral angiography for two of them and coronary angioplasty for the other one). In two patients, the magnetic resonance imaging (MRI) was unremarkable; in the other patient, typical MRI findings were observed, with FLAIR hyperintensities in the right occipital cortex and decreased apparent diffusions coefficient (ADC). Interestingly, this patient also presented posterior rhythmic epileptiform activities on electroencephalogram during the first 36 h. Visual evoked potentials (VEPs) showed normal retinal potential, but a massive destructuration of the later potentials of the cortical origin. To our knowledge, this is the first time that VEPs acquired during TCB are reported. We discuss these findings with respect to the pathophysiology of TCB.
['Baguma|Marius|M|', 'Younan|Nadia|N|', 'London|Frédéric|F|', 'Ossemann|Michel|M|', 'Vandermeeren|Yves|Y|']
D000368:Aged D000792:Angiography D019575:Blindness, Cortical D003287:Contrast Media D004594:Electrophysiology D005074:Evoked Potentials, Visual D005260:Female D006801:Humans D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged
Cortical blindness Electrophysiology Contrast agent Angiography