The Functional Stability of FOXP3 and RORγt in Treg and Th17 and Their Therapeutic Applications.
The balance of CD4+CD25+FOXP3+ regulatory T cells (Tregs) and effector T cells plays a key role in maintaining immune homeostasis, while the imbalance of them is related to many inflammatory diseases in both human and mice. Here we discuss about the plasticity of Tregs and Th17 cells, and the related human diseases resulted from the imbalance of them. Further, we will focus on the mechanisms regulating the plasticity between Tregs and Th17 cells and the potential therapeutic strategies by targeting regulators of the expression and activity of FOXP3 and RORγt or regulators of Treg/Th17 balance in autoimmune diseases, allergy, infection, and cancer.
['Ren|J|J|', 'Li|B|B|']
D000818:Animals D051858:Forkhead Transcription Factors D006801:Humans D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 D055550:Protein Stability D050378:T-Lymphocytes, Regulatory D058504:Th17 Cells
FOXP3 RORγt Tregs Th17 Disease Plasticity