Frequency and risk factors for mental disorders following pancreatitis: a nationwide cohort study.
Objective: To investigate the frequency and risk factors for mental disorders following pancreatitis. Methods: Patients with acute pancreatitis (AP) and chronic pancreatitis (CP) were identified (n = 18,074) from a nationwide database in New Zealand (1998-2015). They were followed from their first hospital admissions for AP or CP to incident mental disorders. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using multivariable Cox regression analyses. Results: CP (vs AP) was associated with a significantly higher risk of mental disorders (adjusted HR = 2.00 [95% CI = 1.53-2.62]). Pre-existing diabetes (adjusted HR = 8.99 [95% CI = 6.23-12.96] for AP and adjusted HR = 3.42 [95% CI = 2.37-4.96] for CP) and post-pancreatitis diabetes mellitus (adjusted HR = 7.10 [95% CI = 4.14-12.19] for AP and adjusted HR = 2.97 [95% CI = 1.83-4.82] for CP) were risk factors for mental disorders in individuals following pancreatitis. Severe (adjusted HR = 2.07 [95% CI = 1.39-3.06] vs mild) and recurrent (adjusted HR = 1.62 [95% CI = 1.07-2.45] vs single episode) attacks were associated with significantly higher risks of mental disorders following AP. Conclusions: Patients following CP, recurrent AP, severe AP, and those with diabetes are at high risk for developing mental disorders.
['Cho|Jaelim|J|', 'Walia|Monika|M|', 'Scragg|Robert|R|', 'Petrov|Maxim S|MS|']
D000208:Acute Disease D000328:Adult D000368:Aged D015331:Cohort Studies D016208:Databases, Factual D003920:Diabetes Mellitus D005260:Female D006760:Hospitalization D006801:Humans D008297:Male D001523:Mental Disorders D008875:Middle Aged D009520:New Zealand D010195:Pancreatitis D050500:Pancreatitis, Chronic D012307:Risk Factors
Mental disorders Pancreatitis Cohort study Prevention