The Persistence of Self-injurious and Aggressive Behavior in Males with Fragile X Syndrome Over 8 Years: A Longitudinal Study of Prevalence and Predictive Risk Markers.
Self-injurious and aggressive behaviors are common in fragile X syndrome (FXS). However, little is known about the persistence of these behaviors and associated risk markers. We established the prevalence and persistence of self-injurious and aggressive behaviors over eight years in males with FXS, and associations with risk markers. Results showed 77% and 69% persistence rates for self-injurious and aggressive behavior, respectively. Baseline levels of repetitive behavior predicted persistent self-injurious behavior. Chronological age, impulsivity and overactivity were associated with persistent aggressive behavior but only impulsivity predicted persistence. This is the first study to document the persistence of self-injurious and aggressive behavior in FXS over the medium to long term and to identify behavioral risk markers that might facilitate targeted early intervention.
['Crawford|Hayley|H|', 'Karakatsani|Efthalia|E|', 'Singla|Gursharan|G|', 'Oliver|Chris|C|']
D000374:Aggression D005260:Female D005500:Follow-Up Studies D005600:Fragile X Syndrome D006801:Humans D007175:Impulsive Behavior D008137:Longitudinal Studies D008297:Male D010290:Parents D015995:Prevalence D011446:Prospective Studies D016728:Self-Injurious Behavior D011795:Surveys and Questionnaires
Aggression Fragile X syndrome Risk markers Repetitive behavior Self-injurious behavior Impulsivity Early intervention Autism Challenging behavior