The effects of Alkanna tinctoria Tausch on split-thickness skin graft donor site management: a randomized, blinded placebo-controlled trial.
BACKGROUND
A prospective, randomized, placebo-controlled clinical trial was conducted to compare the healing effectiveness of Alkanna tinctoria (L.) Tausch (Boraginaceae) with standard dressing on wound healing at the donor site after removal of the skin graft.


METHODS
Enrolled patients were randomly allocated to receive topicalA. tinctoria extract ointment (20%) or standard dressing (dressing with base ointment) daily. Wound healing was assessed using the Bates-Jenson assessment tool at the 2nd and 4th weeks after intervention.


RESULTS
Decreases in wound score were significantly greater in the A. tinctoria group compared with the placebo group (P <0.05). The surface areas of graft donor sites in the A. tinctoria group were significantly reduced as compared with the control group at day 28 of the intervention (P < 0.05). The proportion of patients in the A. tinctoria group achieving complete wound healing within 2 to 4 weeks was 50% and 96.66%, respectively, significantly higher than in patients receiving standard care: 0% and 23.3%, respectively.


CONCLUSIONS
This clinical study showed that A. tinctoria dressing accelerates wound healing after graft harvesting.


TRIAL REGISTRATION
IRCT ID: IRCT201511165781N2 .
['Kheiri|Aliasghar|A|', 'Amini|Shahideh|S|', 'Javidan|Abbas Norouzi|AN|', 'Saghafi|Mohammad Mehdi|MM|', 'Khorasani|Ghasemali|G|http://orcid.org/0000-0001-8608-4919']
D000328:Adult D028082:Boraginaceae D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D010936:Plant Extracts D011446:Prospective Studies D012871:Skin Diseases D016038:Skin Transplantation D014945:Wound Healing D055815:Young Adult
Alkanna Skin graft Healing Wound