Relationship Between Thyroid Hormonal Status in Patients with a Hypothyroid Form of Hashimoto's Thyroiditis and Iodine Concentrations in Drinking Water.
The current study aimed to identify correlative and regressive dependencies between the water iodine concentration and the levels of TSH (thyroid-stimulating hormone), thyroglobulin antibodies (TgAbs), and thyroid peroxidase (TPOAb) in the serum of 168 in patients (34 men and 134 women) with a hypothyroid form of Hashimoto's thyroiditis who use water from the supply network and individual wells. Based on the water iodine concentration, low and moderate degrees of iodine endemia in the location of the patients were determined. In the groups of men and women using water from different water supply sources, there were direct correlations between the water iodine concentrations and the TgAbs and TPOAb titers as well as an inverse dependence between iodine and TSH levels. Multivariate regressive analysis indicated that TgAb and TSH in the group of women using water from a supply network and TPOAb titers in the group of women using well water were independent factors associated with water iodine concentrations. Statistically significant correlations and regressive dependencies between the water iodine concentrations and the biomarkers of the thyroid status of the patients indicate the risk of Hashimoto's thyroiditis progression, especially among women with additional iodine intake.
['Kasiyan|Olha|O|http://orcid.org/0000-0003-0962-0719', 'Tkachenko|Halyna|H|https://orcid.org/0000-0003-3951-9005', 'Kurhaluk|Natalia|N|http://orcid.org/0000-0002-4669-1092', 'Yurchenko|Svitlana|S|http://orcid.org/0000-0002-4055-6367', 'Manenko|Alek|A|http://orcid.org/0000-0002-3919-9876']
D001323:Autoantibodies D060766:Drinking Water D005260:Female D050031:Hashimoto Disease D006801:Humans D007037:Hypothyroidism D007455:Iodine D008297:Male
Water iodine concentration Thyroid-stimulating hormone Thyroglobulin antibodies Endemic region Hashimoto’s thyroiditis Thyroxine peroxidase