Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.
Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-1 and tryptophan. No association was detected between MCP-1 and quinolinic acid. Further studies on the mechanism behind the putative relationship between KYNA and MCP-1 are needed.
['Johansson|Viktoria|V|http://orcid.org/0000-0003-3775-7245', 'Erhardt|Sophie|S|', 'Engberg|Göran|G|', 'Kegel|Magdalena|M|', 'Bhat|Maria|M|', 'Schwieler|Lilly|L|', 'Blennow|Kaj|K|', 'Zetterberg|Henrik|H|', 'Cannon|Tyrone D|TD|', 'Wetterberg|Lennart|L|', 'Hultman|Christina M|CM|', 'Landén|Mikael|M|']
D000328:Adult D000368:Aged D001714:Bipolar Disorder D018932:Chemokine CCL2 D015331:Cohort Studies D005260:Female D006801:Humans D007736:Kynurenic Acid D008297:Male D008875:Middle Aged D017378:Quinolinic Acid D012559:Schizophrenia D013548:Sweden D014364:Tryptophan
Twin study Monocyte chemoattractant protein-1 Kynurenic acid Cerebrospinal fluid Biomarker Chemokine ligand 2