Suspended animation: the past, present and future of major cardiothoracic trauma.
About 50% of the trauma victims die at the scene mostly because of exsanguinating haemorrhage. Most trials of resuscitation fail in face of the ongoing bleeding. Ongoing research/studies to save these victims by inducing rapid hypothermia using cardiopulmonary bypass as an emergency initial measure along with delayed resuscitation show improved outcomes. A comprehensive review of this research and analysis of studies showed that rapid induction of hypothermia within 5 min of cardiac arrest is associated with better survival and improved neurological outcome. This led us to conclude that suspended animation is a lifesaving modality for the treatment of trauma victims, otherwise hurtling towards certain death. This should be integrated into regular clinical practice. The US Food and Drug Administration has given its approval for clinical trials on such an intervention.
['Mohiyaddin|Syed|S|0000-0003-4315-9380', 'Nanjaiah|Prakash|P|', 'Saad|Ahmed O|AO|', 'Acharya|Metesh N|MN|', 'Khan|Tanveer A|TA|', 'Davies|Rhodri H|RH|', 'Ashraf|Saeed|S|']
D000818:Animals D002315:Cardiopulmonary Bypass D018795:Device Approval D004285:Dogs D004638:Emergency Treatment D006323:Heart Arrest D006470:Hemorrhage D006801:Humans D007036:Hypothermia, Induced D051381:Rats D012151:Resuscitation D012771:Shock, Hemorrhagic D013552:Swine D014947:Wounds and Injuries
exsanguination resuscitation massive haemorrhagic operative intervention of cardiothoracic trauma