Recent advances on anti-HIV vaginal delivery systems development.
A review of the recent outcomes regarding technologies to prevent vaginal transmission of HIV, mainly by using antiretroviral (ARV) drugs formulated as microbicides. An introduction about the HIV transmission mechanisms by the vaginal route is included, together with the recent challenges faced for development of successful microbicide products. The outcomes of clinical evaluations are mentioned, and the different formulation strategies studied to-date, with the requirements, advantages, disadvantages and limitations of each dosage-form type, are presented. Finally, the recent attempts to apply various types of nanotechnologies in order to develop advanced microbicide-products and overcome existing limitations, are discussed.
['Antimisiaris|Sophia G|SG|', 'Mourtas|Spyridon|S|']
D000282:Administration, Intravaginal D019380:Anti-HIV Agents D016503:Drug Delivery Systems D005260:Female D015658:HIV Infections D006801:Humans D053758:Nanoparticles D014621:Vagina D066228:Vaginal Absorption D014622:Vaginal Creams, Foams, and Jellies
Vaginal Transmission HIV Formulation Microbicides Nanotechnology AIDS Mucosal