Therapeutic surgery without a definitive diagnosis can be an option in selected patients with suspected lung cancer.
OBJECTIVES
With the recent improvements in the diagnostic accuracy of radiographic modalities, it might be an option to perform therapeutic surgery without a definitive diagnosis for selected patients with suspected lung cancer based on the findings of diagnostic imaging.


METHODS
Between April 2008 and December 2012, all nodules without a definitive diagnosis were classified into five categories according to the probability of lung cancer based on the diagnostic imaging: Category 1 (Benign), Category 2 (Probably benign), Category 3 (Intermediate), Category 4 (Suspected malignancy) and Category 5 (Highly suggestive of malignancy). In this study, the 232 surgical candidates for suspected clinical stage I lung cancer without a preoperative definitive diagnosis were considered to be Category 3 (n = 29), Category 4 (n = 46) and Category 5 (n = 157). Eighty-two patients (72% of Category 3, 46% of Category 4 and 25% of Category 5) had an intraoperative diagnosis during surgery, whereas the remaining 150 patients did not. The final pathological diagnosis and surgical outcomes were analysed.


RESULTS
The final pathological diagnosis of the 232 suspicious nodules revealed 214 lung cancers (52% of Category 3, 93% of Category 4 and 99% of Category 5). Wedge resection was performed for all seven benign tumours. In the multiple regression analysis, intraoperative diagnosis was a significant factor for the length of the operation. In the multivariate logistic regression analysis, the length of the operation was a significant factor predicting both the postoperative morbidity and a prolonged hospital stay.


CONCLUSIONS
Based on a careful clinical decision made using the current diagnostic imaging strategies, patients with a high probability of lung cancer are good candidates for therapeutic surgery, even without a preoperative or intraoperative definitive diagnosis.
['Ozeki|Naoki|N|', 'Iwano|Shingo|S|', 'Taniguchi|Tetsuo|T|', 'Kawaguchi|Koji|K|', 'Fukui|Takayuki|T|', 'Ishiguro|Futoshi|F|', 'Fukumoto|Koichi|K|', 'Nakamura|Shota|S|', 'Hirakawa|Akihiro|A|', 'Yokoi|Kohei|K|']
D000368:Aged D001707:Biopsy, Needle D003937:Diagnosis, Differential D005260:Female D005500:Follow-Up Studies D006801:Humans D007432:Intraoperative Period D008168:Lung D008175:Lung Neoplasms D008297:Male D018579:Patient Selection D011013:Pneumonectomy D012189:Retrospective Studies D014057:Tomography, X-Ray Computed D016896:Treatment Outcome
Surgery Diagnosis Lung cancer Frozen section