Outcomes of IVF cycles coupled with PGS by aCGH of embryos from donor and autologous oocytes, transferred after vitrification to women of advanced maternal age.
It is well documented that aneuploidy rate in preimplantation embryos increases with the mother's age, and at the same time the number of oocytes diminishes. Consequently, for patients of advanced maternal age two options are available to overcome these limitations: use of oocytes from young donors, or use of own oocytes coupled with preimplantation genetic screening (PGS) for 24 chromosomes. However, it is not clear which strategy might be more effective. The aim of this retrospective study was to evaluate outcomes of IVF cycles coupled with transfer of vitrified embryos from donor or autologous oocytes, both with or without PGS. Our results demonstrate that while after PGS clinical pregnancy, twin pregnancy and spontaneous abortion rates are similar for embryos from donor and autologous oocytes, these rates are dramatically worse in all cycles without PGS. Therefore, PGS can be recommended as a screening method to all patients of advanced maternal age even when donor oocytes are used.
['Fedorova|Elena M|EM|', 'Shlykova|Svetlana A|SA|', 'Shunkina|Ksenia V|KV|', 'Zaitceva|Olga G|OG|', 'Lapina|Elena N|EN|', 'Yanchuk|Taras V|TV|', 'Kalugina|Alla S|AS|']
D000328:Adult D000367:Age Factors D055028:Comparative Genomic Hybridization D010064:Embryo Implantation D004624:Embryo Transfer D005260:Female D005307:Fertilization in Vitro D006801:Humans D008423:Maternal Age D018587:Oocyte Donation D011247:Pregnancy D011256:Pregnancy Outcome D019836:Preimplantation Diagnosis D012189:Retrospective Studies D058989:Vitrification
IVF PGS aCGH advanced maternal age aneuploidy Preimplantation genetic screening donor oocytes clinical pregnancy rate