Exercise-stimulated interleukin-15 is controlled by AMPK and regulates skin metabolism and aging.
Aging is commonly associated with a structural deterioration of skin that compromises its barrier function, healing, and susceptibility to disease. Several lines of evidence show that these changes are driven largely by impaired tissue mitochondrial metabolism. While exercise is associated with numerous health benefits, there is no evidence that it affects skin tissue or that endocrine muscle-to-skin signaling occurs. We demonstrate that endurance exercise attenuates age-associated changes to skin in humans and mice and identify exercise-induced IL-15 as a novel regulator of mitochondrial function in aging skin. We show that exercise controls IL-15 expression in part through skeletal muscle AMP-activated protein kinase (AMPK), a central regulator of metabolism, and that the elimination of muscle AMPK causes a deterioration of skin structure. Finally, we establish that daily IL-15 therapy mimics some of the anti-aging effects of exercise on muscle and skin in mice. Thus, we elucidate a mechanism by which exercise confers health benefits to skin and suggest that low-dose IL-15 therapy may prove to be a beneficial strategy to attenuate skin aging.
['Crane|Justin D|JD|', 'MacNeil|Lauren G|LG|', 'Lally|James S|JS|', 'Ford|Rebecca J|RJ|', 'Bujak|Adam L|AL|', 'Brar|Ikdip K|IK|', 'Kemp|Bruce E|BE|', 'Raha|Sandeep|S|', 'Steinberg|Gregory R|GR|', 'Tarnopolsky|Mark A|MA|']
D055372:AMP-Activated Protein Kinases D000328:Adult D000368:Aged D000369:Aged, 80 and over D000375:Aging D000818:Animals D003576:Electron Transport Complex IV D015444:Exercise D005260:Female D005786:Gene Expression Regulation D006801:Humans D019409:Interleukin-15 D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D008875:Middle Aged D008928:Mitochondria D018482:Muscle, Skeletal D009245:NADH Dehydrogenase D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha D010805:Physical Conditioning, Animal D012333:RNA, Messenger D015398:Signal Transduction D012867:Skin D014157:Transcription Factors
skin metabolism aging exercise muscle mitochondria