Design, synthesis and in vitro anti-mycobacterial activities of homonuclear and heteronuclear bis-isatin derivatives.
A series of novel homonuclear and heteronuclear bis-isatin derivatives tethered through ethylene were designed, synthesized and evaluated for their in vitro anti-mycobacterial activities against MTB H37Rv and MDR-TB. All hybrids exhibited potential anti-mycobacterial activities against MTB H37Rv and MDR-TB with MIC ranging from 16 to 256 μg/mL. In particular, the heteronuclear bis-isatin 4i (MIC: 25 and 16 μg/mL) was most active against MTB H37Rv and MDR-TB strains, and could act as a lead for further optimization.
['Xu|Yan|Y|', 'Guan|Jianguo|J|', 'Xu|Zhi|Z|', 'Zhao|Shijia|S|']
D000995:Antitubercular Agents D015195:Drug Design D005030:Ethylenes D007510:Isatin D008826:Microbial Sensitivity Tests D015394:Molecular Structure D009169:Mycobacterium tuberculosis D013329:Structure-Activity Relationship
Anti-mycobacterial Homonuclear Heteronuclear Dimer Isatin Structure-activity relationship