Effects of zinc and magnesium supplements on postpartum depression and anxiety: A randomized controlled clinical trial.
Postpartum anxiety and depression are prevalent disorders. The authors of this study aimed to determine the effects of zinc and magnesium supplements on depressive symptoms and anxiety in postpartum women referred to three governmental, educational hospitals in Tabriz, Iran during 2014-2015. In this triple-blind, randomized, controlled clinical trial, the participants were randomly assigned to the zinc sulfate, magnesium sulfate, and placebo groups (n = 33 per group). The intervention groups received a 27-mg zinc sulfate tablet or 320-mg magnesium sulfate tablet per day for 8 weeks, whereas the control group received a placebo tablet each day during the same period. The Edinburgh Postnatal Depression Scale and the Spielberger State-Trait Anxiety Inventory were completed before and 8 weeks after the intervention. Blood samples were drawn from each participant to determine serum levels of zinc and magnesium before intervention at 48 hours after delivery. Also, a 24-hour dietary questionnaire was used during the first and last 3 days of the intervention. Adjusting for baseline scores as well as zinc and magnesium serum levels, no significant difference was observed between groups 8 weeks after delivery in mean scores of depressive symptoms (p = .553), state anxiety (p = .995), and trait anxiety (p = .234). This study concluded magnesium and zinc did not reduce postpartum anxiety and depressive symptoms.
['Fard|Fatemeh Edalati|FE|', 'Mirghafourvand|Mojgan|M|', 'Mohammad-Alizadeh Charandabi|Sakineh|S|', 'Farshbaf-Khalili|Azizeh|A|', 'Javadzadeh|Yousef|Y|', 'Asgharian|Hanieh|H|']
D000328:Adult D001007:Anxiety D019052:Depression, Postpartum D019587:Dietary Supplements D005260:Female D006801:Humans D008278:Magnesium Sulfate D049590:Postpartum Period D011247:Pregnancy D011569:Psychiatric Status Rating Scales D016896:Treatment Outcome D019287:Zinc Sulfate
zinc magnesium postpartum Anxiety depressive symptoms