Anti-diabetic effect mediated by Ramulus mori polysaccharides.
Diabetes mellitus is a complicated metabolic disease, whose pathogenesis is related to apoptosis within pancreatic tissue. In this study, the potential therapeutic benefits of Ramulus mori polysaccharides (RMP) on streptozotocin (STZ)-induced diabetic mice were evaluated. Our experiments indicated that RMP lowered hyperglycemia and increased insulin levels in diabetic mice. Histopathological examination revealed that RMP contributed to the reduction of STZ-lesioned pancreatic cells. In addition, the serum level of HbA1c was decreased. RMP treatment also showed increased Bcl-2 expression and reduced Bax protein level in pancreatic tissue. Furthermore, intrapancreatic expressions of p-JNK, p-p38 and cleaved-caspase-3 were down-regulated by RMP treatment. Collectively, the findings demonstrate that RMP exerts the pronounced hypoglycemic effect via regulation of the intrapancreatic JNK/p38 pathway to protect against STZ-induced apoptosis in pancreatic tissue, eventually ameliorating metabolic function in the pancreas.
['Xu|Lingyuan|L|', 'Yang|Fenglian|F|', 'Wang|Junli|J|', 'Huang|Hao|H|', 'Huang|Yanqiang|Y|']
D000818:Animals D017209:Apoptosis D001835:Body Weight D053148:Caspase 3 D003921:Diabetes Mellitus, Experimental D005215:Fasting D015971:Gene Expression Regulation, Enzymologic D006442:Glycated Hemoglobin A D007004:Hypoglycemic Agents D007328:Insulin D048031:JNK Mitogen-Activated Protein Kinases D008297:Male D051379:Mice D031625:Morus D010179:Pancreas D010750:Phosphoproteins D011134:Polysaccharides D059748:Proteolysis D015854:Up-Regulation D048051:p38 Mitogen-Activated Protein Kinases
Ramulus mori polysaccharides Metabolism Apoptosis Hyperglycemia