Corneal Collagen Crosslinking for Post-LASIK Ectasia: An Australian Study.
PURPOSE
Post laser-assisted in situ keratomileusis (LASIK) ectasia is a rare and unpredictable complication after LASIK. Corneal collagen crosslinking (CXL) has emerged as a promising technique to address this complication. Our study evaluates the long-term efficacy of CXL for post-LASIK ectasia in an Australian setting.


DESIGN
Retrospective review of post-LASIK ectasia patients referred to and treated at 3 corneal refractive surgery institutions in Sydney, Australia.


METHODS
Eleven patients (14 eyes; mean age, 39.7 ± 12.6 years) underwent epithelium-off CXL with follow-up ranging from 12-78 months. Best spectacle-corrected visual acuity (BSCVA), simulated keratometry, corneal topography indices, and higher-order aberrations (HOAs) [mean ± standard error of the mean (SEM)] were measured with a rotating Scheimpflug camera (Pentacam, Oculus). Comparisons between baseline measurements and postoperative outcomes were performed using paired t test analysis.


RESULTS
At last follow-up, BSCVA improved significantly by 0.2 ± 0.06 logMAR (P = 0.01), and 12 of 14 eyes showed no keratometric deterioration. Of the corneal topography indices, index of height asymmetry showed a trend toward a significant improvement (P = 0.05). There was no progression of corneal HOAs. Central corneal thickness was not significantly altered (P = 0.6). No major postoperative complications were observed.


CONCLUSIONS
In the Australian setting, CXL has proven effective at stabilizing the progression of post-LASIK ectasia, inducing corneal regularity, and improving visual acuity.
['Tong|Jessica Y|JY|', 'Viswanathan|Deepa|D|', 'Hodge|Christopher|C|', 'Sutton|Gerard|G|', 'Chan|Colin|C|', 'Males|John J|JJ|']
D000328:Adult D003094:Collagen D003315:Cornea D003316:Corneal Diseases D019781:Corneal Topography D003432:Cross-Linking Reagents D004108:Dilatation, Pathologic D005260:Female D005500:Follow-Up Studies D006801:Humans D020731:Keratomileusis, Laser In Situ D008297:Male D009216:Myopia D011183:Postoperative Complications D011184:Postoperative Period D012029:Refraction, Ocular D012189:Retrospective Studies D016896:Treatment Outcome
crosslinking ectasia LASIK refractive surgery