Plumbagin and Its Role in Chronic Diseases.
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is a plant-derived naphthoquinones obtained mainly from three families, including Plumbaginaceae, Droseraceae, and Ebenaceae. Plumbagin has exhibited its potential therapeutic benefits on numerous chronic diseases, i.e., breast cancer, non-small cell lung cancer, melanoma, ovarian, squamous cell carcinomas, pancreatic cancer, and prostate cancer. In addition, its anti-inflammatory and antimicrobial activities as well as control of diabetes and cardiovascular diseases have been reported. Thus, plumbagin is a promising agent for development as a new drug for the treatment or control of chronic diseases. Studies on controlled drug release or drug delivery systems have been involved for improvement of its therapeutic efficacy as well as for the reduction of its toxicity. However, most of the recent research information is from in vitro and in vivo studies. Further clinical studies are therefore required for its developments and applications as a novel drug used to treat chronic diseases.
['Panichayupakaranant|Pharkphoom|P|', 'Ahmad|Md Iftekhar|MI|']
D000818:Animals D000890:Anti-Infective Agents D000893:Anti-Inflammatory Agents D000972:Antineoplastic Agents, Phytogenic D002317:Cardiovascular Agents D002908:Chronic Disease D055808:Drug Discovery D006801:Humans D007004:Hypoglycemic Agents D015394:Molecular Structure D009285:Naphthoquinones D008517:Phytotherapy D010946:Plants, Medicinal D015398:Signal Transduction
Plumbagin Chronic diseases Antimicrobial Cardiovascular Toxicity Anti-inflammation Anticancer Antidiabetic