Gonococcal urethritis caused by a multidrug resistant Neisseria gonorrhoeae strain with high-level resistance to spectinomycin in China.
We report a recent (2018) gonorrhoeal urethritis caused by a multidrug-resistant Neisseria gonorrhoeae strain in China. The isolated N. gonorrhoeae strain from a male and female pair expressed high-level resistance to spectinomycin (SPC), azithromycin, and other antibiotics but was sensitive to ceftriaxone. The SPC high-level resistance (MIC = 2048 mg/L) was due to a small deletion in rspE that caused two amino acid changes in ribosomal protein S5.
['Chen|Shao-Chun|SC|', 'Hu|Li-Hua|LH|', 'Zhu|Xiao-Yu|XY|', 'Yin|Yue-Ping|YP|']
D002681:China D024901:Drug Resistance, Multiple, Bacterial D009344:Neisseria gonorrhoeae D010641:Phenotype D012269:Ribosomal Proteins D000198:Spectinomycin
urethritis resistance Neisseria gonorrhoeae spectinomycin treatment failure