An overview of microRNAs: Biology, functions, therapeutics, and analysis methods.
MicroRNAs (miRNAs) are a class of small noncoding RNAs, which function in posttranscriptional regulation of gene expression. They are powerful regulators of various cellular activities including cell growth, differentiation, development, and apoptosis. They have been linked to many diseases, and currently miRNA-mediated clinical trial has shown promising results for treatment of cancer and viral infection. This review provides an overview and update on miRNAs biogenesis, regulation of miRNAs expression, their biological functions, and role of miRNAs in epigenetics and cell-cell communication. In addition, alteration of miRNAs following exercise, their association with diseases, and therapeutic potential will be explained. Finally, miRNA bioinformatics tools and conventional methods for miRNA detection and quantification will be discussed.
['Saliminejad|Kioomars|K|', 'Khorram Khorshid|Hamid Reza|HR|', 'Soleymani Fard|Shahrzad|S|', 'Ghaffari|Seyed Hamidollah|SH|0000-0002-4172-2208']
D000818:Animals D002450:Cell Communication D019295:Computational Biology D044127:Epigenesis, Genetic D015444:Exercise D005786:Gene Expression Regulation D059014:High-Throughput Nucleotide Sequencing D006801:Humans D035683:MicroRNAs D009369:Neoplasms D015398:Signal Transduction
microRNA therapeutics gene expression epigenetics intercellular communication