Bioinformatic analyses revealed underlying biological functions correlated with oxaliplatin responsiveness.
Colorectal cancer is one of the most common cancers worldwide. Surgery is usually the primary treatment for colon cancers that have not spread to distant sites. However, chemotherapy may be considered after surgery to eliminate remaining cancer cells or in case the cancer has a high risk of recurrence. Oxaliplatin is often used in combination regimens such as FOLFOX, CapeOX, and FOLFOXIRI because of the cost-effectiveness of adjuvant treatment for patients and also the good tolerability profile. However, some patients show resistance to oxaliplatin which causes poor treatment outcomes. Most colon cancer studies focused on treatments and patient survival. Some studies focused on genetic associations of specific genes. However, pathway and network analyses of oxaliplatin resistance in colon cancer cells using gene expression patterns are still lacking. We performed a microarray analysis and found that endothelin-1 (EDN1), dishevelled segment polarity protein (DV1), toll-like receptor 5(TLR5), mitogen-activated protein kinase 3 (MAP2K3), phosphatidylinositol-4,5-bisphosphate 3-kinase, and catalytic subunit beta (PIK3CB) were closely related to responsiveness to oxaliplatin treatment. Furthermore, we found that the signal transduction, melanogenesis, and toll-like receptor signaling pathways might be involved in oxaliplatin-resistant colon cancer. These genes and pathways might be potential targets for improving oxaliplatin treatment in colon cancer patients.
['Klahan|Sukhontip|S|', 'Huang|Chi-Cheng|CC|', 'Chien|Shu-Chen|SC|', 'Wu|Mei-Shin|MS|', 'Wong|Henry Sung-Ching|HS|', 'Huang|Chien-Yu|CY|', 'Chang|Wei-Chiao|WC|', 'Wei|Po-Li|PL|']
D000970:Antineoplastic Agents D016000:Cluster Analysis D003110:Colonic Neoplasms D019295:Computational Biology D030541:Databases, Genetic D019008:Drug Resistance, Neoplasm D020869:Gene Expression Profiling D015972:Gene Expression Regulation, Neoplastic D053263:Gene Regulatory Networks D006801:Humans D053858:Metabolic Networks and Pathways D008954:Models, Biological D009944:Organoplatinum Compounds D000077150:Oxaliplatin D025941:Protein Interaction Mapping D060066:Protein Interaction Maps D015398:Signal Transduction D016896:Treatment Outcome
Oxaliplatin Colon cancer Bioinformatic analysis Network and pathway analysis