The CTGF gene -945 G/C polymorphism is associated with target lesion revascularization for in-stent restenosis.
BACKGROUND AND AIMS
Previous studies have shown that transforming growth factor β (TGF-β) and vascular endothelial growth factor A (VEGF-A) pathways are involved in the in-stent restenosis (ISR) process. The present study aimed to assess the relationship between single-nucleotide polymorphisms (SNPs) in genes encoding downstream proteins of TGF-β and VEGF-A pathways and the risk of target lesion revascularization (TLR) for in-stent restenosis.


METHODS
A total of 657 patients (with 781 treated lesions) who underwent percutaneous coronary intervention (PCI) with stent implantation at our center between 2007 and 2012 and completed a 4-year follow-up for clinically-driven TLR, were included. SNPs in CTGF (rs6918698), TGFBR2 (rs2228048), SMAD3 (rs17293632), KDR (rs2071559), CCL2 (rs1024610) were genotyped using TaqMan assay.


RESULTS
Major allele carriers of CTGF gene -945 G/C polymorphism (rs6918698) were significantly less likely to underwent clinically-driven TLR during follow-up than minor allele carriers. After adjustment for clinical, angiographic, and procedural covariates, CTGF polymorphism was significantly associated with TLR, and minor allele (C) carriers had nearly two times higher risk of developing ISR requiring TLR (HR of 1.93, 95%CI 1.15-3.24) compared to patients with major (GG) genotype. No significant relationship was found between other analyzed polymorphisms and cumulative incidence of TLR at 4-years.


CONCLUSIONS
Our results suggest that functional -945 G/C polymorphism in the gene encoding connective tissue growth factor is associated with the need for TLR in patients who underwent PCI for stable coronary artery disease.
['Bujak|Kamil|K|', 'Lejawa|Mateusz|M|', 'Gąsior|Mariusz|M|', 'Osadnik|Tadeusz|T|']
D000368:Aged D015415:Biomarkers D055513:Connective Tissue Growth Factor D003324:Coronary Artery Disease D023903:Coronary Restenosis D005260:Female D005838:Genotype D006801:Humans D008297:Male D008875:Middle Aged D009204:Myocardial Revascularization D020641:Polymorphism, Single Nucleotide D011379:Prognosis D012042:Registries D015996:Survival Rate
CTGF Polymorphism Restenosis TGFBR2