Preparation of poly(L-lactic acid)-modified polypropylene mesh and its antiadhesion in experimental abdominal wall defect repair.
A new type of polypropylene (PP) hernia mesh, modified with poly(L-lactic acid) (PLLA), was developed and used to repair rat abdominal wall defect. The PP mesh was first treated with oxygen plasma and then grafted with PLLA in phosphorus pentachloride (PCl5 ) solution in dichloride methane. The water contact angle changed during the procedure, and the coverage percentage of PLLA on the PP was about 80%. ATR-FTIR spectroscopy measurements showed the existence of carbonyl group absorption peak (1756.9 cm(-1) ), and atomic force microscope and scanning electron microscope morphological observation indicated that the surface of the PP mesh was covered with PLLA graft. X-ray photoelectron spectroscopy spectra was used to probe chemical group changes and confirmed that the PLLA was grafted onto the PP. A total of 36 Sprague-Dawley rats were randomly divided into six groups, and they received either modified meshes (experimental groups) or PP meshes (control groups) to repair abdominal wall defects. All animals survived until the end of the experiment. Rats in each group were dissected after the operation (after 1 week, 2 weeks, and 1 month, respectively), and the adhesion effects were evaluated. Sections of the mesh parietal peritoneum overlap were examined histologically and graded for inflammation reaction. Compared with the control groups, the experimental groups showed a better ability to resist peritoneal cavity adhesions (P < 0.05), and there was no increase in inflammation formation (P > 0.05). This new type of PLLA-modified PP mesh displayed an additional property of antiadhesion in animal abdominal wall defect repair.
['Zhang|Zhigang|Z|', 'Zhang|Tianzhu|T|', 'Li|Junsheng|J|', 'Ji|Zhenling|Z|', 'Zhou|Hemei|H|', 'Zhou|Xuefeng|X|', 'Gu|Ning|N|']
D034861:Abdominal Wall D000818:Animals D001672:Biocompatible Materials D005260:Female D059685:Herniorrhaphy D057927:Hydrophobic and Hydrophilic Interactions D007249:Inflammation D019344:Lactic Acid D008422:Materials Testing D018625:Microscopy, Atomic Force D008855:Microscopy, Electron, Scanning D056951:Photoelectron Spectroscopy D011091:Polyesters D011108:Polymers D011126:Polypropylenes D051381:Rats D017207:Rats, Sprague-Dawley D017550:Spectroscopy, Fourier Transform Infrared D013526:Surgical Mesh D000267:Tissue Adhesions
polypropylene mesh antiadhesion poly(l-lactic acid) hernia repair