New onset seizures as a sole clinical presentation of multiple sclerosis.
BACKGROUND AND OBJECTIVES
Epileptic seizures frequently occur in people with multiple sclerosis (MS) and are thought to represent a manifestation of cortical pathology. However, at present, seizures are not considered to be a typical clinical presentation of demyelination.


METHODS AND RESULTS
In this case series, we identified four people, who presented with seizures as a sole presenting feature, with demyelinating imaging abnormalities that satisfy current diagnostic criteria for a clinically isolated syndrome (CIS) or early MS.


CONCLUSION
Based on this case series, we propose that people presenting with de novo seizures, with concurrent radiological abnormalities suggestive of demyelination could potentially be considered to have a CIS.
['Al Hussona|Mariam|M|', 'Kearney|Hugh|H|', 'Fisher|Arie|A|', 'Lynch|John|J|', 'Looby|Seamus|S|', 'Delanty|Norman|N|']
D000328:Adult D005260:Female D006801:Humans D009103:Multiple Sclerosis D012640:Seizures D055815:Young Adult
Multiple sclerosis cortical lesions electroencephalogram epilepsy temporal lobe