Paraneoplastic neuromyelitis optica and ovarian teratoma: A case series.
Neuromyelitis optica spectrum disorder (NMOSD) is a rare inflammatory disease of the central nervous system, characterized by the presence of auto-antibodies directed against aquaporin-4 (AQP4) expressed on astrocyte end-feet. Despite NMOSD does not primarily belong to the spectrum of paraneoplastic neurological syndromes, rare cases of association with neoplasia have been outlined. Here, we report the association of NMOSD with ovarian teratoma in 3 cases. Pathological analysis of teratomas revealed glial component strongly expressing AQP4 and closely localized to immune infiltrates. Our series highlight the rare association of teratoma with NMOSD and the possible paraneoplastic mechanism.
['Bernard-Valnet|Raphaël|R|', 'Cobo-Calvo|Alvaro|A|', 'Siegfried|Aurore|A|', 'Marasescu|Raluca|R|', 'Bonnan|Mickael|M|', 'Ballan|Guillaume|G|', 'Ellie|Emmanuel|E|', 'Bauer|Jan|J|', 'Uro-Coste|Emmanuelle|E|', 'Marignier|Romain|R|', 'Brassat|David|D|']
D000293:Adolescent D000328:Adult D051401:Aquaporin 4 D005260:Female D006801:Humans D009471:Neuromyelitis Optica D010051:Ovarian Neoplasms D013724:Teratoma D055815:Young Adult
Neuromyelitis optica Ovarian teratoma Autoimmune diseases Demyelinating diseases Paraneoplastic syndromes