Rhein Derivatives, A Promising Pivot?
Rhein, an anthraquinone derivative, has been employed widely, especially for the treatment of intractable diseases like diabetic nephropathy, arthritis, and cancer in a unique action mechanism. In the last decades, considerable efforts have been made in structural modification of rhein. This paper reviewed patents on pharmacological activity and therapeutic application of rhein and its derivatives from 1978 to 2018. Particularly, an analysis of patents was made, with the top 10 most valuable patents presented, and the interpretation of the legal status of patents was given. Given the properties of superior pharmacological activity, rich resources, cheap price, low toxicity, and mature extraction process, it is believed that an in-depth investigation on rhein and its derivatives is worth trying.
['Pei|Rui|R|', 'Jiang|Yueping|Y|', 'Lei|Guanghua|G|', 'Chen|Jingjing|J|', 'Liu|Manhua|M|', 'Liu|Shao|S|']
D000818:Animals D000880:Anthraquinones D001168:Arthritis D045744:Cell Line, Tumor D002626:Chemistry, Pharmaceutical D003928:Diabetic Nephropathies D015195:Drug Design D006801:Humans D007249:Inflammation D020128:Inhibitory Concentration 50 D009369:Neoplasms
rhein anthraquinone derivative patent pharmacological activity therapeutic application drug development