Adipose Tissue-Derived Stem Cells: Immunomodulatory Effects and Therapeutic Potential.
Adipose-derived stem cells (ASCs) can self-renew and differentiate along multiple cell lineages. ASCs are also potently anti-inflammatory due to their inherent ability to regulate the immune system by secreting anti-inflammatory cytokines and growth factors that play a crucial role in the pathology of many diseases, including multiple sclerosis, diabetes mellitus, Crohn's, SLE, and graft-versus-host disease. The immunomodulatory effects and mechanisms of action of ASCs on pathological conditions are reviewed here.
['Al-Ghadban|Sara|S|', 'Bunnell|Bruce A|BA|']
D000273:Adipose Tissue D000818:Animals D002454:Cell Differentiation D006801:Humans D045164:Mesenchymal Stem Cell Transplantation D059630:Mesenchymal Stem Cells D013234:Stem Cells
adipose-derived stem cells cytokines mechanisms of action immune cells immunological disease stromal vascular fraction