Renal threshold for glucose reabsorption predicts diabetes improvement by sodium-glucose cotransporter 2 inhibitor therapy.
In the present study we examined the efficacy of sodium-glucose cotransporter 2 inhibitors on improvement of glycated hemoglobin (HbA1c) in comparison with the renal threshold for glucose reabsorption in patients with type 2 diabetes mellitus. Patients visited the hospital once a month for a regular follow-up examination with the determination of blood glucose and HbA1c levels, and urinary glucose concentration from spot urine samples. Patient samples were compared before and after ipragliflozin administration. We defined the renal threshold for glucose reabsorption as the lowest blood glucose level that correlated with the first detectable appearance of urine glucose. These data showed a significant negative correlation between improvement of HbA1c level and renal threshold for glucose reabsorption in patients treated with the sodium-glucose cotransporter 2 inhibitor. These findings show that patients who have a higher renal threshold for glucose reabsorption can be expected to more effectively respond to sodium-glucose cotransporter 2 inhibitor therapy in terms of lowering HbA1c levels.
['Osaki|Aya|A|', 'Okada|Shuichi|S|', 'Saito|Tsugumichi|T|', 'Yamada|Eijiro|E|', 'Ono|Kumeo|K|', 'Niijima|Yawara|Y|', 'Hoshi|Hiroto|H|', 'Yamada|Masanobu|M|']
D000368:Aged D000369:Aged, 80 and over D001786:Blood Glucose D003924:Diabetes Mellitus, Type 2 D005260:Female D005960:Glucosides D006442:Glycated Hemoglobin A D006029:Glycosuria D006801:Humans D007004:Hypoglycemic Agents D008297:Male D008875:Middle Aged D065608:Renal Reabsorption D000077203:Sodium-Glucose Transporter 2 Inhibitors D013876:Thiophenes D016896:Treatment Outcome
Renal threshold for glucose reabsorption Sodium-glucose cotransporter 2 inhibitor Type 2 diabetes mellitus