SNAP23 promotes the malignant process of ovarian cancer.
BACKGROUND
Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC.


METHODS
We determined the expression of SNAP23 in OC tissues and explored the clinical significance through bioinformatics analysis. The effects of SNAP23 on OC cell proliferation, migration, invasion, cell cycle and apoptosis were then evaluated in vitro.


RESULTS
SNAP23 is hyper-expressed in OC tumor tissues compared to normal tissues, and increased expression of SNAP23 is associated with a poor progression free survival (HR = 1.24, 95% CI = 1.07-1.44, p = 0.0042). SNAP23 knock down increases cell apoptosis and inhibits cell proliferation, migration and invasion of OC cells. GO analysis reveals that most genes correlated highly with SNAP23 were enriched in metabolic process.


CONCLUSIONS
Our data suggest that SNAP23 may serve as an oncogene promoting tumorigenicity of OC cells by decreasing apoptotic process.
['Sun|Qi|Q|', 'Huang|Xing|X|', 'Zhang|Quanli|Q|', 'Qu|Junwei|J|', 'Shen|Yang|Y|', 'Wang|Xin|X|', 'Sun|Haijun|H|', 'Wang|Jie|J|', 'Xu|Lin|L|', 'Chen|Xiaoxiang|X|', 'Ren|Binhui|B|']
D045744:Cell Line, Tumor D002465:Cell Movement D049109:Cell Proliferation D018450:Disease Progression D005260:Female D015972:Gene Expression Regulation, Neoplastic D006801:Humans D009361:Neoplasm Invasiveness D010051:Ovarian Neoplasms D011379:Prognosis D050766:Qb-SNARE Proteins D050767:Qc-SNARE Proteins D015854:Up-Regulation
SNAP23 Ovarian cancer SNARE Apoptosis