Ferritin H gene deletion in the choroid plexus and forebrain results in hydrocephalus.
Ferritin H, the major iron storage protein, has essential functions in early embryonic development as well as in adult liver and intestine. To address the question whether ferritin H has similarly essential functions in the brain we used the Cre/loxP system to generate mice with a forebrain-specific inactivation of the ferritin H gene. Ferritin H deficiency in most cells of the forebrain including cells of the choroid plexus caused accumulation of cerebrospinal fluid in the lateral ventricles and the subarachnoid space. Brain tissue iron content was unchanged.
['Schweizer|Claude|C|', 'Fraering|Patrick C|PC|', 'Kühn|Lukas C|LC|']
D000818:Animals D001052:Apoferritins D002540:Cerebral Cortex D002552:Cerebral Ventricles D002831:Choroid Plexus D017353:Gene Deletion D018398:Homeodomain Proteins D006849:Hydrocephalus D007501:Iron D051379:Mice D008810:Mice, Inbred C57BL D018345:Mice, Knockout D016548:Prosencephalon D014157:Transcription Factors
Ferritin H Iron Brain Mice Blood brain barrier