Chronic inflammation confers to the metabolic reprogramming associated with tumorigenesis of colorectal cancer.
It's well known that microenvironment inflammatory signals could promote cancer development and progression. In colorectal cancer (CRC), chronic inflammation is a major driving mechanism for the development of CRC in patients having long-standing inflammatory bowel disease (IBD). Though it has been addressed that cancer cells ferment much of their glucose supply into lactate regardless of the presence of oxygen, it is unclear whether cell metabolism has been reprogramed during the process from IBD to CRC. Herein, with dextran sulfate sodium (DSS)-induced mouse colitis model, we found that inflammation upregulated key glycolytic enzymes expression via activation of STAT3/c-Myc signaling pathway. Interestingly, during the whole phase of chronic inflammation, the key metabolic enzymes demonstrated increased expression constantly, indicating the metabolic reprogramming was induced by long-term inflammatory signal. Moreover, either the inhibition of STAT3 signaling or c-Myc activity could block the glycolytic enzymes expression induced by interleukin 6 (IL-6). Thus, we presented the view that inflammation could induce the metabolic reprogramming and promote the progression from chronic colitis to colorectal cancer.
['Qu|Dingding|D|', 'Shen|Liangliang|L|', 'Liu|Shaoqing|S|', 'Li|Huichen|H|', 'Ma|Yongzheng|Y|', 'Zhang|Ruohan|R|', 'Wu|Kaichun|K|', 'Yao|Libo|L|', 'Li|Jipeng|J|', 'Zhang|Jian|J|']
D000818:Animals D063646:Carcinogenesis D002471:Cell Transformation, Neoplastic D002908:Chronic Disease D003093:Colitis, Ulcerative D003106:Colon D015179:Colorectal Neoplasms D016264:Dextran Sulfate D004195:Disease Models, Animal D006019:Glycolysis D006801:Humans D007150:Immunohistochemistry D015850:Interleukin-6 D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D016271:Proto-Oncogene Proteins c-myc D050796:STAT3 Transcription Factor D015398:Signal Transduction D059016:Tumor Microenvironment
Chronic inflammation metabolic reprogramming STAT3 c-Myc IL-6