Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis.
Circular RNAs (circRNAs) are novel non-coding RNAs, which show abnormal expression in several diseases, such as atherosclerosis (AS). The purpose of the present study was to reveal the association between hsa_circ_0004543 and AS. In the present study, hsa_circ_0004543 was overexpressed in human umbilical vein endothelial cells (HUVECs) induced by oxidized low-density lipoprotein (oxLDL). Inhibition of hsa_circ_0004543 expression facilitated the proliferation, migration, and invasion of HUVECs and significantly reduced their apoptotic rate following treatment with oxLDL. Furthermore, silencing of hsa_circ_0004543 activated the PI3K/AKT/NOS3 pathway in oxLDL-induced HUVECs. Collectively, these results demonstrated that hsa_circ_0004543 may play a vital role in the development of AS and affect the proliferation of HUVECs, providing a potential target for treating endothelial cell damage in AS.
['Han|Lu|L|', 'Li|Dandan|D|', 'Hang|Yanwen|Y|', 'Zong|Xiaojuan|X|', 'Lv|Jiashun|J|', 'Bai|Xiaolu|X|', 'Lu|Yi|Y|', 'Zhang|Peng|P|', 'Zhou|Meiling|M|', 'Wu|Zhaodi|Z|', 'Hu|Wei|W|']
hsa_circ_0004543 vascular endothelial cells angiogenesis atherosclerosis treatment