Genes associated with Type 2 Diabetes and vascular complications.
Type 2 Diabetes (T2D) is a chronic disease associated with a number of micro- and macrovascular complications that increase the morbidity and mortality of patients. The risk of diabetic complications has a strong genetic component. To this end, we sought to evaluate the association of 40 single nucleotide polymorphisms (SNPs) in 21 candidate genes with T2D and its vascular complications in 503 T2D patients and 580 healthy controls. The genes were chosen because previously reported to be associated with T2D complications and/or with the aging process. We replicated the association of T2D risk with IGF2BP rs4402960 and detected novel associations with TERT rs2735940 and rs2736098. The addition of these SNPs to a model including traditional risk factors slightly improved risk prediction. After stratification of patients according to the presence/absence of vascular complications, we found significant associations of variants in the CAT, FTO, and UCP1 genes with diabetic retinopathy and nephropathy. Additionally, a variant in the ADIPOQ gene was found associated with macrovascular complications. Notably, these genes are involved in some way in mitochondrial biology and reactive oxygen species regulation. Hence, our findings strongly suggest a potential link between mitochondrial oxidative homeostasis and individual predisposition to diabetic vascular complications.
['Montesanto|Alberto|A|', 'Bonfigli|Anna Rita|AR|', 'Crocco|Paolina|P|', 'Garagnani|Paolo|P|', 'De Luca|Maria|M|', 'Boemi|Massimo|M|', 'Marasco|Elena|E|', 'Pirazzini|Chiara|C|', 'Giuliani|Cristina|C|', 'Franceschi|Claudio|C|', 'Passarino|Giuseppe|G|', 'Testa|Roberto|R|', 'Olivieri|Fabiola|F|', 'Rose|Giuseppina|G|']
D000368:Aged D000375:Aging D019540:Area Under Curve D016022:Case-Control Studies D003924:Diabetes Mellitus, Type 2 D003925:Diabetic Angiopathies D005260:Female D020022:Genetic Predisposition to Disease D006801:Humans D008297:Male D008875:Middle Aged D020641:Polymorphism, Single Nucleotide D016601:RNA-Binding Proteins D019098:Telomerase
Type 2 Diabetes diabetes complications SNP aging genetic profile