Evaluation of glutathione S-transferase genetic variants affecting type 2 diabetes susceptibility: a meta-analysis.
Genetic polymorphisms of glutathione S-transferases (GSTs) and type 2 diabetes mellitus (T2DM) risk have been widely studied, however, the results were somewhat conflicting. To evaluate the association of GSTs (GSTM1, GSTT1 and GSTP1) gene polymorphisms with T2DM, a meta-analysis was performed before October, 2012. ORs were pooled according to random-effects model. There were a total of 1354/1666 (n=9) cases/controls (studies) for GSTM1, 1271/1470 (n=8) for GSTT1, and 1205/1250 (n=7) for GSTM1. There were significant associations between GSTM1 polymorphism, GSTT1 polymorphism and T2DM in the contrast of present genotype vs. null genotype, with pooled OR=1.99 (95%CI=1.46-2.71) and OR=1.61 (95%CI=1.19-2.17), respectively. Yet no significant association of GSTP1 polymorphism and T2DM was showed. When stratified by ethnicity, the significant associations were also existed in Asians for GSTM1 and GSTT1, but not GSTP1. No publication bias but some extent of heterogeneity was observed. Finally, the accumulated evidence proved the obvious associations of GSTM1 and GSTT1 polymorphisms with an increased risk of T2DM.
['Tang|Song-Tao|ST|', 'Wang|Chang-Jiang|CJ|', 'Tang|Hai-Qin|HQ|', 'Zhang|Qiu|Q|', 'Wang|Yuan|Y|']
D000328:Adult D000368:Aged D016022:Case-Control Studies D003924:Diabetes Mellitus, Type 2 D005260:Female D020022:Genetic Predisposition to Disease D005838:Genotype D051549:Glutathione S-Transferase pi D005982:Glutathione Transferase D006801:Humans D008297:Male D008875:Middle Aged D011110:Polymorphism, Genetic D012306:Risk
Glutathione S-transferase Glutathione S-transferase Diabetes Susceptibility Meta-analysis GSTs type 2 diabetes mellitus T2DM OR CI GSTM GSTP GSTT HWE Hardy–Weinberg equilibrium PCR PCR-RFLP R ROS confidence interval glutathione S-transferase-mu glutathione S-transferase-pi glutathione S-transferase-theta glutathione S-transferases odds ratio polymerase chain reaction polymerase chain reaction with restriction fragment length polymorphism random effect model reactive oxygen species