Progress toward understanding chromosome silencing by Xist RNA.
The X inactive-specific transcript (Xist) gene is the master regulator of X chromosome inactivation in mammals. Xist produces a long noncoding (lnc)RNA that accumulates over the entire length of the chromosome from which it is transcribed, recruiting factors to modify underlying chromatin and silence X-linked genes in cis Recent years have seen significant progress in identifying important functional elements in Xist RNA, their associated RNA-binding proteins (RBPs), and the downstream pathways for chromatin modification and gene silencing. In this review, we summarize progress in understanding both how these pathways function in Xist-mediated silencing and the complex interplay between them.
['Brockdorff|Neil|N|', 'Bowness|Joseph S|JS|', 'Wei|Guifeng|G|']
D004268:DNA-Binding Proteins D020868:Gene Silencing D008780:Methyltransferases D011506:Proteins D062085:RNA, Long Noncoding D016601:RNA-Binding Proteins D018160:Receptors, Cytoplasmic and Nuclear D049951:X Chromosome Inactivation
Xist X chromosome inactivation chromatin LBR NCoR–HDAC3 Polycomb RBM15 SPEN m6A RNA methylation