Treatment recommendations for elderly patients with newly diagnosed glioblastoma lack worldwide consensus.
BACKGROUND
Glioblastoma predominantly occurs in the 6th and 7th decades of life. The optimal treatment paradigm for elderly patients is not well established. We sampled current worldwide management strategies for elderly patients with newly diagnosed glioblastoma.


METHODS
A web-based survey was developed and distributed to 168 radiation oncologists, neuro-oncologists and neurosurgeons identified through the United Council for Neurologic Subspecialties and the CNS committees for North American, European and Asian Organizations. Questions addressed treatment recommendations in order to determine whether management consensus exists in this patient subset.


RESULTS
There were 68 (40%) respondents. Across respondents, the most important factors directing treatment were KPS (94%) and MGMT methylation status (71%). Only 37% of respondents strictly factor in age when making treatment recommendations with 59% defining elderly as greater than 70 years-old. The most common treatment recommendations for MGMT-methylated elderly patients with KPS > 70 were as follows: standard chemoRT (49%), short course chemoRT (39%), and temozolomide alone (30%). The most common treatment recommendations for MGMT-unmethylated patients with KPS > 70 were as follows: short course RT alone (51%), standard chemoRT (38%), and short course chemoRT (28%). Treatment recommendations for patients with KPS < 50 were short course RT alone (40%), best supportive care (57%), or TMZ alone (17%). Individuals practicing in North America were significantly more likely to recommend standard chemoradiation for patients compared to their European counterparts.


CONCLUSION
Worldwide treatment recommendations for elderly patients with newly diagnosed GBM vary widely. Further randomized studies are needed to elucidate the optimal treatment strategy for this subset of patients.
['Palmer|Joshua D|JD|', 'Bhamidipati|Deepak|D|', 'Mehta|Minesh|M|', 'Williams|Noelle L|NL|', 'Dicker|Adam P|AP|', 'Werner-Wasik|Maria|M|', 'Shi|Wenyin|W|']
D000368:Aged D024221:Antineoplastic Protocols D001932:Brain Neoplasms D002986:Clinical Trials as Topic D032921:Consensus D019468:Disease Management D005909:Glioblastoma D006801:Humans D038622:Internationality D017410:Practice Guidelines as Topic D010818:Practice Patterns, Physicians' D011795:Surveys and Questionnaires
Treatment recommendations Elderly Glioblastoma