Two new compounds from the roots of Ilex pubescens and their cytotoxic activity.
A new phenylethanoid, 1-O-β-D-(4-hydroxyphenyl)-ethyl-6-O-vanilloyl-glucopyranoside (1), and a new furofuran lignan, (7R,7'R,7''S,8S,8'S,8''R)-4', 4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7'9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol (2), along with five known compounds (3-7) were isolated from the roots of Ilex pubescens. Their chemical structures were elucidated on the basis of extensive spectroscopic analysis, including UV, IR, MS, and NMR experiments. In addition, compounds 2-7 were evaluated in vitro for their cytotoxic effects on human HeLa cells; among them, compounds 2, 3, 6, and 7 showed cytotoxic activity against HeLa cells in the test.
['Xiong|Huan|H|', 'Zhao|Fang|F|', 'Bi|Jiayi|J|', 'Zhang|Yang|Y|', 'Zhao|Guiyun|G|', 'Chen|Xue|X|', 'Li|Yuncong|Y|', 'Yan|Rui|R|', 'Zhao|Qiang|Q|', 'Qiao|Hua|H|', 'Zhang|Guogang|G|']
D006367:HeLa Cells D006801:Humans D030017:Ilex D009682:Magnetic Resonance Spectroscopy D015394:Molecular Structure D018517:Plant Roots
Ilex pubescens Cytotoxic activity Phenylethanoid Lignans