Association between CLEC4E gene polymorphism of mincle and pulmonary tuberculosis infection in a northern Chinese population.
BACKGROUND
Pulmonary tuberculosis caused by an intracellular pathogen, Mycobacterium tuberculosis continues to exist as a hazardous disease to human life globally. Genetic polymorphisms regulate resistance and susceptibility to tuberculosis. The C-type lectin receptor of family 4 member E (CLEC4E) confers protection against tuberculosis in laboratory animals but its function in influencing exposure or resistance to pulmonary tuberculosis (PTB) in humans remains obscure.


AIM
We conducted this research to analyze the effects or concomitance of CLEC4E gene variations with susceptibility to pulmonary tuberculosis in a northern Chinese population.


METHOD
In this study, 202 participants with pulmonary tuberculosis and 214 controls without PTB were enrolled. Two single nucleotide polymorphisms (SNPs) for CLEC4E on chromosome 12 were selected with a minor allele frequency of >0.05. All the SNPs were genotyped using high resolution melting analysis-PCR.


RESULTS
We estimated and compared two SNPs, rs10841845 and rs10841847. From our study findings, CLEC4E rs10841845 conferred protection against the development of pulmonary TB with a P value of <0.05 and odds ratio of <1 for all models of genetic inheritance. CLEC4E rs10841847 genotypes in co-dominant, Recessive, Dominant models and alleles had a significant statistical difference between patients and controls associated with resistance against the development of PTB (P<0.05 and OR<1).


CONCLUSION
Our findings suggest that variations at rs10841845 and rs10841847 of CLEC4E genes are associated with increased individual protection against PTB.
['Kabuye|Deo|D|', 'Chu|Yang|Y|', 'Lao|Wenting|W|', 'Jin|Guojiang|G|', 'Kang|Hui|H|']
D044466:Asians D016022:Case-Control Studies D002881:Chromosomes, Human, Pair 12 D060467:Disease Resistance D005260:Female D005787:Gene Frequency D006801:Humans D037181:Lectins, C-Type D008297:Male D016017:Odds Ratio D020641:Polymorphism, Single Nucleotide D011971:Receptors, Immunologic D014397:Tuberculosis, Pulmonary
Human C-type lectin Chromosome 12 Allele frequency Genotype Confidence interval