New Concepts, Concerns, and Creations in Acne.
Laboratory monitoring for patients on isotretinoin should include creatinine kinase in athletic males and the more liver-specific gamma glutamyltransferase. There is mounting evidence that acne pathophysiology includes a barrier defect and subsequent microbiome disruption. Avoidance of acne scars with early and aggressive treatment is a more efficient and cost-effective option than subsequent treatment. Laser and light treatments for acne and acne scars are plentiful but poorly supported by evidence-based medicine. The acne pipeline is rich with new chemical entities, new formulations, and combinations of older agents. The gold standard for acne therapy may be changing its face.
['Marson|Justin W|JW|', 'Baldwin|Hilary E|HE|']
D000152:Acne Vulgaris D000900:Anti-Bacterial Agents D002921:Cicatrix D003402:Creatine Kinase D003879:Dermatologic Agents D005145:Face D006801:Humans D062325:Intense Pulsed Light Therapy D015474:Isotretinoin D008111:Liver Function Tests D064307:Microbiota D010778:Photochemotherapy D056692:Prebiotics D019936:Probiotics D012176:Retinoids D012629:Sebum D012867:Skin
Acne Gamma glutamyltransferase Microbiome Acne scarring Acne pipeline Creatine kinase