Sorption behaviors of antimicrobial and antiparasitic veterinary drugs on subtropical soils.
Brazil is one of the world's largest producers of animal protein, requiring the large-scale use of veterinary drugs. The administration of antimicrobials and antiparasitics is a common practice. However, there is a lack of information on how these drugs impact the environment. Antimicrobials are capable of altering the soil microbial population and are responsible for the development of multidrug-resistant microbial strains. Therefore, it is important to evaluate the fate and transport of these compounds in the environment, and one parameter used for this purpose is the soil-water partition coefficient. In this work, an assessment was made of the soil sorption behaviors of 18 drugs from seven different families, including antimicrobials (sulfonamides, fluoroquinolones, amphenicols, and macrolides) and antiparasitic drugs (milbemycin, avermectins, and benzimidazoles). Seven subtropical soils of different textural classes were tested. The Freundlich sorption coefficients, expressed as μg1-1/n (cm3)1/n g-1, were in the following ranges: 0.45 to 19 (sulfonamides), 72 to 2410 (fluoroquinolones), 9 to 58 (thiabendazole), 0.03 to 0.48 (florfenicol), 105 to 424 (moxidectin), 14 to 184 (avermectins), and 1.5 to 74 (macrolides). The results showed that the drugs belonging to the same family, with chemical structures in common, presented similar behaviors regarding sorption and desorption, for the different soils tested and are generally in agreement with soils from temperate regions. The data set obtained in this work give an overview of the fate of the veterinary drugs in Brazilian subtropical soils with different textures and composition and can be very helpful for exposure risk assessments.
['Rath|Susanne|S|', 'Fostier|Anne Hélène|AH|', 'Pereira|Leandro Alves|LA|', 'Dioniso|Andreza Camilotti|AC|', 'de Oliveira Ferreira|Fabrício|F|', 'Doretto|Keity Margareth|KM|', 'Maniero Peruchi|Livia|L|', 'Viera|Alessandra|A|', 'de Oliveira Neto|Odilon França|OF|', 'Dal Bosco|Sandra Maria|SM|', 'Martínez-Mejía|Mónica J|MJ|']
D000327:Adsorption D000818:Animals D000900:Anti-Bacterial Agents D000977:Antiparasitic Agents D001938:Brazil D024841:Fluoroquinolones D007559:Ivermectin D012987:Soil D012989:Soil Pollutants D013449:Sulfonamides D013827:Thiabendazole D019155:Veterinary Drugs
Veterinary drugs Sorption coefficients Brazilian subtropical soils Freundlich isotherms Sorption kinetics