Bariatric surgery decreased the serum level of an endotoxin-associated marker: lipopolysaccharide-binding protein.
BACKGROUND
Recent studies have shown serum lipopolysaccharide binding protein (LBP) is associated with obesity and related metabolic disorder. Bariatric surgery can significantly reduce weight, but reports about the change of LBP after bariatric surgery are limited. We investigated LBP concentration and its associations with clinical variables.


METHODS
We enrolled 178 obese patients receiving different bariatric surgeries and 38 normal weight individuals. Fasting blood samples were collected at baseline in all and 1 year after surgery in obese individuals. The serum LBP concentration was measured.


RESULTS
The percentage of excess weight loss of mini-gastric bypass, Roux-en-Y gastric bypass, sleeve gastrectomy, and adjustable gastric band were 72.0±20.0%, 65.5±23.0%, 67.2±18.4%, and 16.1±14.3%, respectively. Serum LBP levels were higher in the obese participants than in the normal weight participants (49.9±15.7 versus 25.2±7.5 μg/mL; P<.001) at baseline and significantly decreased to 35.1±22.6 μg/mL after bariatric surgery (P<.001) in the obese group. In the bariatric participants, after multivariate analyses, preoperative LBP and the change of LBP with surgery were independently associated only with high sensitive C-reactive protein (hs-CRP) (P<.001) and the change of hs-CRP (P = .012), respectively, while none of the postoperative variables was independently associated with LBP.


CONCLUSION
LBP is associated with body mass index and hs-CRP. Bariatric surgery significantly decreased the serum level of LBP. The relationship between LBP and hs-CRP disappeared after bariatric surgery.
['Yang|Po-Jen|PJ|', 'Lee|Wei-Jei|WJ|', 'Tseng|Ping-Huei|PH|', 'Lee|Po-Huang|PH|', 'Lin|Ming-Tsan|MT|', 'Yang|Wei-Shiung|WS|']
D000209:Acute-Phase Proteins D000328:Adult D050110:Bariatric Surgery D015415:Biomarkers D015992:Body Mass Index D002097:C-Reactive Protein D002352:Carrier Proteins D015331:Cohort Studies D005260:Female D005500:Follow-Up Studies D005743:Gastrectomy D015390:Gastric Bypass D015391:Gastroplasty D006801:Humans D016014:Linear Models D008297:Male D008562:Membrane Glycoproteins D008875:Middle Aged D015999:Multivariate Analysis D009767:Obesity, Morbid D011182:Postoperative Care D011300:Preoperative Care D011446:Prospective Studies D016896:Treatment Outcome D015431:Weight Loss
Bariatric surgery LBP Obesity hs-CRP