Cytosolic DNA Sensing in Organismal Tumor Control.
Besides constituting a first layer of defense against microbial challenges, the detection of cytosolic DNA is fundamental for mammalian organisms to control malignant transformation and tumor progression. The accumulation of DNA in the cytoplasm can initiate the proliferative inactivation (via cellular senescence) or elimination (via regulated cell death) of neoplastic cell precursors. Moreover, cytosolic DNA sensing is intimately connected to the secretion of cytokines that support innate and adaptive antitumor immunity. Here, we discuss the molecular mechanisms whereby cytosolic DNA enables cell-intrinsic and -extrinsic oncosuppression, and their relevance for the development of novel therapeutic approaches that reinstate anticancer immunosurveillance.
['Vanpouille-Box|Claire|C|', 'Demaria|Sandra|S|', 'Formenti|Silvia C|SC|', 'Galluzzi|Lorenzo|L|']
D000818:Animals D017209:Apoptosis D002471:Cell Transformation, Neoplastic D016922:Cellular Senescence D003600:Cytosol D004247:DNA D006801:Humans D007157:Immunologic Surveillance D009369:Neoplasms
CGAS STING ZBP1 apoptosis inflammasome micronuclei mtDNA necroptosis pyroptosis type I interferon