Diagnosis of oral lichen planus from analysis of saliva samples using terahertz time-domain spectroscopy and chemometrics.
The ability to diagnose oral lichen planus (OLP) based on saliva analysis using THz time-domain spectroscopy and chemometrics is discussed. The study involved 30 patients (2 male and 28 female) with OLP. This group consisted of two subgroups with the erosive form of OLP (n  =  15) and with the reticular and papular forms of OLP (n  =  15). The control group consisted of six healthy volunteers (one male and five females) without inflammation in the mucous membrane in the oral cavity and without periodontitis. Principal component analysis was used to reveal informative features in the experimental data. The one-versus-one multiclass classifier using support vector machine binary classifiers was used. The two-stage classification approach using several absorption spectra scans for an individual saliva sample provided 100% accuracy of differential classification between OLP subgroups and control group.
['Kistenev|Yury|Y|', 'Borisov|Alexey|A|', 'Titarenko|Maria|M|', 'Baydik|Olga|O|', 'Shapovalov|Alexander|A|']
D003584:Cytological Techniques D004847:Epithelial Cells D005260:Female D006801:Humans D017676:Lichen Planus, Oral D008297:Male D025341:Principal Component Analysis D012463:Saliva D012815:Signal Processing, Computer-Assisted D060388:Support Vector Machine D055068:Terahertz Spectroscopy
oral lichen planus saliva terahertz time-domain spectroscopy chemometrics exfoliative cytology