Salivary and serum level of CYFRA 21-1 in oral precancer and oral squamous cell carcinoma.
BACKGROUND
CYFRA 21-1, a constituent of the intermediate filament proteins of epithelial cells, is known to be increased in many cancers. This study was designed to estimate the levels of salivary and serum CYFRA 21-1 in patients with oral precancer and oral squamous cell carcinoma (OSCC) and compare them with healthy controls.


MATERIALS AND METHODS
Each group comprised of 100 subjects. Saliva and blood samples were collected from patients with OSCC, premalignant subjects, and normal healthy subjects. Serum and salivary CYFRA 21-1 levels were measured by enzyme-linked immunosorbent assay. Appropriate statistical tests were employed to assess diagnostic potency of CYFRA 21-1.


RESULTS
We found a significant increase in CYFRA 21-1 level in OSCC compared with PML and healthy subjects. Salivary CYFRA 21-1 levels in OSCC was threefold higher when compared to serum levels. PML group showed increased salivary CYFRA 21-1 when compared to control subjects, but it was significantly lower compared with OSCC. Receiver operator characteristic curve analysis showed salivary CYFRA 21-1 to have superior sensitivity in detecting OSCC compared with serum CYFRA 21-1.


CONCLUSIONS
The outcome of this study suggests that salivary CYFRA 21-1 can be utilized as a biomarker in early detection of oral cancer.
['Rajkumar|K|K|', 'Ramya|R|R|', 'Nandhini|G|G|', 'Rajashree|P|P|', 'Ramesh Kumar|A|A|', 'Nirmala Anandan|S|S|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D000951:Antigens, Neoplasm D014408:Biomarkers, Tumor D002294:Carcinoma, Squamous Cell D016022:Case-Control Studies D004797:Enzyme-Linked Immunosorbent Assay D005260:Female D006801:Humans D053539:Keratin-19 D008297:Male D008875:Middle Aged D009062:Mouth Neoplasms D011230:Precancerous Conditions D012463:Saliva D055815:Young Adult
CYFRA 21-1 squamous cell carcinoma oral cancer diagnosis premalignant lesion