Teaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approaches.
Autophagy is a lysosomal mediated degradation activity providing an essential mechanism for recycling cellular constituents, and clearance of excess or damaged lipids, proteins and organelles. Autophagy involves more than 30 proteins and is regulated by nutrient availability, and various stress sensing signaling pathways. This article provides an overview of the mechanisms and regulation of autophagy, its role in health and diseases, and methods for its measurement. Hopefully this teaching review together with the graphic illustrations will be helpful for instructors teaching graduate students who are interested in grasping the concepts and major research areas and introducing recent developments in the field.
['Zhang|Jianhua|J|']
D000375:Aging D051017:Apoptosis Regulatory Proteins D001343:Autophagy D000071186:Beclin-1 D003141:Communicable Diseases D005786:Gene Expression Regulation D006801:Humans D008565:Membrane Proteins D008869:Microtubule-Associated Proteins D008928:Mitochondria D063306:Mitophagy D008967:Molecular Biology D009369:Neoplasms D019636:Neurodegenerative Diseases D010084:Oxidation-Reduction D018384:Oxidative Stress D015398:Signal Transduction D058570:TOR Serine-Threonine Kinases
Aging Beclin LC3 Mitochondria Neurodegenerative diseases mTOR