Diagnostic Performance of Multiparametric Transrectal Ultrasound in Localized Prostate Cancer: A Comparative Study With Magnetic Resonance Imaging.
OBJECTIVES
The aim of this study was to compare the diagnostic performance of multiparametric transrectal ultrasound (TRUS), including grayscale imaging, color Doppler imaging, shear wave elastography, and contrast-enhanced ultrasound, to that of multiparametric magnetic resonance imaging (MRI), including T2-weighted, diffusion-weighted, and dynamic contrast-enhanced MRI, in the diagnosis of localized prostate cancer (PCa; lesions at stage T2 or lower).


METHODS
Seventy-eight patients were prospectively enrolled, including 40 in a benign prostate group and 38 in a localized PCa group (≤T2). The diagnostic performance of multiparametric TRUS and multiparametric MRI in detecting localized PCa was analyzed with surgical and biopsy pathologic results as the references.


RESULTS
Multiparametric TRUS had higher sensitivity, negative predictive value, and accuracy than multiparametric MRI (97.4% versus 94.7%, 96.9% versus 92.3%, and 87.2% versus 76.9%, respectively) for detecting localized PCa. The mean area under the receiver operating characteristic curve ± SD for multiparametric TRUS was 0.874 ± 0.043 (95% confidence interval, 0.790-0.959), and it was 0.774 ± 0.055 (95% confidence interval, 0.666-0.881) for multiparametric MRI.


CONCLUSIONS
Our results suggest that multiparametric TRUS has high diagnostic performance in the diagnosis of localized PCa. Multiparametric TRUS is compatible with multiparametric MRI in the detection of localized PCa (≤T2).
['Zhang|Mingbo|M|https://orcid.org/0000-0002-7990-3493', 'Tang|Jie|J|', 'Luo|Yukun|Y|', 'Wang|Yiru|Y|', 'Wu|Meng|M|', 'Memmott|Benjamin|B|', 'Gao|Jing|J|https://orcid.org/0000-0001-5993-042X']
D000368:Aged D003287:Contrast Media D038524:Diffusion Magnetic Resonance Imaging D006801:Humans D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D011446:Prospective Studies D011471:Prostatic Neoplasms D012007:Rectum D012680:Sensitivity and Specificity D018615:Ultrasonography, Doppler, Color
transrectal ultrasound prostate cancer magnetic resonance imaging