ADP-ribosyl-N₃: A Versatile Precursor for Divergent Syntheses of ADP-ribosylated Compounds.
Adenosine diphosphate-ribose (ADP-ribose) and its derivatives play important roles in a series of complex physiological procedures. The design and synthesis of artificial ADP-ribosylated compounds is an efficient way to develop valuable chemical biology tools and discover new drug candidates. However, the synthesis of ADP-ribosylated compounds is currently difficult due to structural complexity, easily broken pyrophosphate bond and high hydrophilicity. In this paper, ADP-ribosyl-N₃ was designed and synthesized for the first time. With ADP-ribosyl-N₃ as the key precursor, a divergent post-modification strategy was developed to prepare structurally diverse ADP-ribosylated compounds including novel nucleotides and peptides bearing ADP-ribosyl moieties.
['Li|Lingjun|L|', 'Li|Qianqian|Q|', 'Ding|Shengqiang|S|', 'Xin|Pengyang|P|', 'Zhang|Yuqin|Y|', 'Huang|Shenlong|S|', 'Zhang|Guisheng|G|']
D000074744:ADP-Ribosylation D000246:Adenosine Diphosphate Ribose D060326:Chemistry Techniques, Synthetic D011756:Diphosphates D057927:Hydrophobic and Hydrophilic Interactions D009682:Magnetic Resonance Spectroscopy D013058:Mass Spectrometry D015394:Molecular Structure D009711:Nucleotides D010455:Peptides
ADP-ribosylated compounds nucleotides divergent synthesis