Peptide Amphiphile Nanostructures for Targeting of Atherosclerotic Plaque and Drug Delivery.
Co-assembled peptide amphiphile nanofibers designed to target atherosclerotic plaque and enhance cholesterol efflux are shown to encapsulate and deliver a liver X receptor agonist to increase efflux from murine macrophages in vitro. Fluorescence microscopy reveals that the nanofibers, which display an apolipoprotein-mimetic peptide, localize at plaque sites in LDL receptor knockout mice with or without the encapsulated molecule, while nanofibers displaying a scrambled, non-targeting peptide sequence do not demonstrate comparable binding. These results show that nanofibers functionalized with apolipoprotein-mimetic peptides may be effective vehicles for intravascular targeted drug delivery to treat atherosclerosis.
['So|Miranda M|MM|', 'Mansukhani|Neel A|NA|', 'Peters|Erica B|EB|', 'Albaghdadi|Mazen S|MS|', 'Wang|Zheng|Z|', 'Pérez|Charles M Rubert|CMR|', 'Kibbe|Melina R|MR|', 'Stupp|Samuel I|SI|']
peptides atherosclerosis self-assembly supramolecular chemistry