Enteral Baicalin, a Flavone Glycoside, Reduces Indicators of Cardiac Surgery-Associated Acute Kidney Injury in Rats.
BACKGROUND/AIMS
Cardiac surgery-associated acute kidney injury (CSA-AKI) is one of the most common postoperative complications in intensive care medicine. Baicalin has been shown to have anti-inflammatory and antioxidant roles in various disorders. We aimed to test the protective effects of baicalin on CSA-AKI using a rat model.


METHODS
Sprague-Dawley rats underwent 75 min of cardiopulmonary bypass (CPB) with 45 min of cardioplegic arrest (CA) to establish the AKI model. Baicalin was administered at different doses intragastrically 1 h before CPB. The control and treated rats were subjected to the evaluation of different kidney injury index and inflammation biomarkers.


RESULTS
Baicalin significantly attenuated CPB/CA-induced AKI in rats, as evidenced by the lower levels of serum creatinine, serum NGAL, and Kim1. Baicalin remarkably inhibited oxidative stress, reflected in the decreased malondialdehyde and myeloperoxidase activity, and enhanced superoxide dismutase activity and glutathione in renal tissue. Baicalin suppressed the expression of IL-18 and iNOS, and activated the Nrf2/HO-1 pathway.


CONCLUSION
Our data indicated that baicalin mediated CPB/CA-induced AKI by decreasing the oxidative stress and inflammation in the renal tissues, and that baicalin possesses the potential to be developed as a therapeutic tool in clinical use for CSA-AKI.
['Shi|Jing|J|', 'Wu|Guofeng|G|', 'Zou|Xiaohua|X|', 'Jiang|Ke|K|']
D058186:Acute Kidney Injury D000818:Animals D015415:Biomarkers D006348:Cardiac Surgical Procedures D004195:Disease Models, Animal D004750:Enteral Nutrition D004791:Enzyme Inhibitors D047309:Flavones D005419:Flavonoids D008297:Male D008315:Malondialdehyde D018384:Oxidative Stress D009195:Peroxidase D011183:Postoperative Complications D051381:Rats D017207:Rats, Sprague-Dawley
Baicalin Acute kidney injury Cardiopulmonary bypass Nrf2/HO-1 pathway Cardiac surgery