Our experience in the management of prostate cancer in renal transplant recipients.
INTRODUCTION AND OBJECTIVES
The management of Prostate cancer (PCa) in renal transplant recipients (RTR) is challenging and remain controversial. Currently there is no consensus about this condition. The aim of the study was to analyse our experience in the diagnosis and management of PCa in RTR.


METHOD
Retrospective monocentric study of a prospective and consecutive database from 2003-2017. Inclusion of RTR diagnosed of PCa. Staging and treatment in agreement with the contemporary guidelines. The main outcome measures included clinical staging, type of treatment, oncological outcomes and follow-up.


RESULTS
1,330 renal transplants were performed (787 males), diagnosed of PCa in 33 RTR (4.2%), mean age 66years±6.3 (51-78). Median PSA was 8.8ng/ml and PSA ratio 0.19. Mean time between renal transplantation and PCa diagnosis 130months±90 (2-236).


TREATMENTS
Radical prostatectomy (RP) (n=22; 66.7%), Radiation therapy (RT) with Androgen deprivation therapy (ADT) (n=7; 21.2%), Active surveillance (n=3; 9.1%), ADT (n=1; 3%). No graft loss neither impaired renal function due to PCa treatment was reported. After RP two patients (9.1%) presented biochemical recurrence treated with RT. Remission of the 100%. Mean follow-up was 61months±37 (6-132).


CONCLUSIONS
PCa in renal transplant patients can be managed with the same therapeutic options as in the general population. Active surveillance should also be provided in RTR despite being under immunosuppressive therapy.
['Narváez|A|A|', 'Suarez|J|J|', 'Riera|L|L|', 'Castells-Esteve|M|M|', 'Cocera|R|R|', 'Vigués|F|F|']
D000368:Aged D006801:Humans D016030:Kidney Transplantation D008297:Male D008875:Middle Aged D011183:Postoperative Complications D011471:Prostatic Neoplasms D012189:Retrospective Studies D016896:Treatment Outcome
Prostate cancer Renal transplant Radical prostatectomy Active surveillance Biochemical recurrence Cáncer de próstata Prostatectomía radical Recidiva bioquímica Trasplante renal Vigilancia activa