Positive clinical effects of gamma knife capsulotomy in a patient with deep brain stimulation-refractory Tourette Syndrome and Obsessive Compulsive Disorder.
We report the first case of a patient with severe, intractable Tourette Syndrome with comorbid Obsessive Compulsive disorder, who recovered from both disorders with gamma-knife (GK) stereotactic radiosurgery following deep brain stimulation (DBS). This case highlights the possible role of the internal capsule within the neural circuitries underlying both TS and OCD, and suggests that in cases of treatment-refractory TS and comorbid OCD, bilateral anterior capsulotomy using stereotactic radiosurgery may be a viable treatment option.
['Richieri|Raphaëlle|R|', 'Blackman|Graham|G|', 'Musil|Richard|R|', 'Spatola|Giorgio|G|', 'Cavanna|Andrea E|AE|', 'Lançon|Christophe|C|', 'Régis|Jean|J|']
D046690:Deep Brain Stimulation D005260:Female D006801:Humans D020772:Internal Capsule D008875:Middle Aged D009771:Obsessive-Compulsive Disorder D016634:Radiosurgery D005879:Tourette Syndrome D016896:Treatment Outcome
Capsulotomy Tourette syndrome Obsessive compulsive disorder Deep brain stimulation