Management guideline for Werner syndrome 2020. 2. Sarcopenia associated with Werner syndrome.
AIM
Sarcopenia is defined as a condition that combines decreased skeletal muscle mass with weakness or decreased physical function. It is well known that in older adults, the presence of sarcopenia is a risk of frailty, falls and physical dysfunction. Patients with Werner syndrome are characterized by visceral fat accumulation and thin limbs, but the prevalence of sarcopenia in patients with Werner syndrome has not been investigated.


METHODS
A literature search was conducted using Werner syndrome and skeletal muscle as keywords. We also analyzed data from our 7 Werner syndrome patients.


RESULTS
A literature search on the relationship between Werner syndrome and skeletal muscle yielded only one article reported from Japan. According to this paper, a decrease in skeletal muscle mass (appendicular skeletal muscle index) was observed in all 9 Werner syndromes investigated. On the other hand, in our 7 Werner syndrome patients, their appendicular skeletal muscle indexes were below the standard value except for one male patient who had continued resistance exercise.


CONCLUSION
The decrease in skeletal muscle mass frequently occurs in patients with Werner syndrome. However, resistance exercise may prevent the appearance of sarcopenia and requires early intervention in patients with Werner syndrome. Geriatr Gerontol Int 2021; 21: 139-141.
['Kuzuya|Masafumi|M|https://orcid.org/0000-0002-6134-9578', 'Takemoto|Minoru|M|https://orcid.org/0000-0002-9599-2465', 'Kubota|Yoshitaka|Y|', 'Taniguchi|Toshibumi|T|', 'Motegi|Sei-Ichiro|SI|', 'Taniguchi|Akira|A|', 'Nakagami|Hironori|H|https://orcid.org/0000-0003-4494-3601', 'Maezawa|Yoshiro|Y|', 'Koshizaka|Masaya|M|https://orcid.org/0000-0001-7374-9993', 'Kato|Hisaya|H|', 'Mori|Seijiro|S|', 'Tsukamoto|Kazuhisa|K|', 'Yokote|Koutaro|K|']
D000368:Aged D015444:Exercise D000073496:Frailty D006801:Humans D008297:Male D053580:Muscle Strength D018482:Muscle, Skeletal D055948:Sarcopenia D014898:Werner Syndrome
management guideline Werner syndrome others clinical medicine geriatric medicine