Inhibitory Activities of Phenolic Compounds Isolated from Adina rubella Leaves Against 5α-Reductase Associated with Benign Prostatic Hypertrophy.
Adina rubella Hance (AR), a plant native to Korea, has been used as traditional medicine for dysentery, eczema, intoxication, and external hemorrhages. Previous phytochemical studies of AR have reported several components, including terpenoids, phenolics, and alkaloids. The current study evaluated the anti-oxidative and anti-inflammatory activities and 5α-reductase inhibition of isolated compounds of AR leaves to find a potential therapeutic agent for benign prostatic hypertrophy (BPH). Repeated chromatographic isolation of an 80% acetone extract of AR leaves yielded seven phenolic compounds: caffeic acid (1), chlorogenic acid (2), methyl chlorogenate (3), quercetin-3-rutinoside (4), kaempferol-3-O-α-l-rhamnopyranosyl-(1→6)-β-d-glucopyranoside (5), hyperoside (6), and grandifloroside (7). Compound 7 is a novel compound in AR. Caffeoyl derivatives 1-3 and 7 showed good anti-oxidative activities. In particular, caffeic acid (1) and grandifloroside (7) showed potent anti-inflammatory activities, and 7 also exhibited potent inhibitory activity against TNF-α and 5α-reductase. Our results show that the extract and grandifloroside (7) from leaves of AR might be developed as a source of potent anti-oxidative and anti-inflammatory agents and therapeutic agent for BPH.
['Yin|Jun|J|', 'Heo|Jun Hyeok|JH|', 'Hwang|Yoon Jeong|YJ|', 'Le|Thi Tam|TT|', 'Lee|Min Won|MW|']
D058891:5-alpha Reductase Inhibitors D000818:Animals D000893:Anti-Inflammatory Agents D000975:Antioxidants D002460:Cell Line D016207:Cytokines D004789:Enzyme Activation D006801:Humans D020128:Inhibitory Concentration 50 D008297:Male D051379:Mice D015394:Molecular Structure D010636:Phenols D010936:Plant Extracts D018515:Plant Leaves D011470:Prostatic Hyperplasia D019666:Rubiaceae
5α-reductase benign prostatic hypertrophy Adina rubella Hance anti-oxidative anti-inflammatory