Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides.
Four new steroid saponins 1-4 were isolated from the rhizomes of Anemarrhena asphodeloides (Asparagaceae), as well as four known saponins: anemarsaponin B (5) timosaponin D (6), timosaponin E1 (7) anemarsaponin B II (8). Their structures were established through UV and NMR as well as MS data. All the compounds were evaluated for cytotoxicity against HepG2 and SGC7901 human cancer lines. Compounds 3 and 7 displayed medium antiproliferative activities on HepG2 and SGC7901 cells, with IC50 values of 43.90 and 57.90 μM, respectively.
['Yang|Bing-You|BY|', 'Zhang|Jing|J|', 'Liu|Yan|Y|', 'Kuang|Hai-Xue|HX|']
D031403:Anemarrhena D000972:Antineoplastic Agents, Phytogenic D045744:Cell Line, Tumor D049109:Cell Proliferation D056945:Hep G2 Cells D006801:Humans D015394:Molecular Structure D010936:Plant Extracts D027343:Rhizome D012503:Saponins D013256:Steroids D014315:Triterpenes
Asparagaceae cytotoxicity MTT furostanol saponin spirostanol saponin