Intestinal obstruction in pregnancy by ondansetron.
BACKGROUND
Ondansetron use for nausea and vomiting during pregnancy has increased in the last years, although its maternal and fetal safety is not conclusive.


CASE
We describe a case of intestinal obstruction in a pregnant woman with severe nausea and vomiting of pregnancy treated with ondansetron, which is known to slow gut motility.


CONCLUSION
The spontaneous reporting system of WHO confirms that this potentially life threatening complication is more common than what the peer review literature may suggest and needs to be looked into carefully, especially in view of the wide spread off-label use for NVP.
['Cohen|Rana|R|', 'Shlomo|Meital|M|', 'Dil|Dorit Nahlieli|DN|', 'Dinavitser|Natalia|N|', 'Berkovitch|Mati|M|', 'Koren|Gideon|G|']
D000328:Adult D000932:Antiemetics D005260:Female D006801:Humans D007415:Intestinal Obstruction D017294:Ondansetron D011247:Pregnancy D012702:Serotonin Antagonists
Intestinal obstruction Pregnancy Ondansetron 5-HT3 receptor antagonist Adverse event Hyperemesis gravidarum