Influence of molecular characteristics in the prognosis of methicillin-resistant Staphylococcus aureus prosthetic joint infections: beyond the species and the antibiogram.
We have explored the relationship of phenotypic (antibiogram, β-haemolysis, agr functionality, biofilm formation) and genotypic characteristics on the prognosis of 18 cases of methicillin-resistant S. aureus prosthetic joint infection (2005-2015). All isolates belonged to CC5, and had agr type II. This pilot study suggests that phage-borne genes belonging to the immune evasion cluster (chp, sak and scn) were more frequent among episodes with treatment failure (80.0 vs. 37.5%).
['Muñoz-Gallego|Irene|I|', 'Lora-Tamayo|Jaime|J|', 'Pérez-Montarelo|Dafne|D|', 'Brañas|Patricia|P|', 'Viedma|Esther|E|', 'Chaves|Fernando|F|']
D000368:Aged D000369:Aged, 80 and over D001178:Arthroplasty D018441:Biofilms D015331:Cohort Studies D005260:Female D005838:Genotype D006461:Hemolysis D006785:Hospitals, University D006801:Humans D007592:Joint Diseases D008297:Male D055624:Methicillin-Resistant Staphylococcus aureus D008826:Microbial Sensitivity Tests D008875:Middle Aged D010865:Pilot Projects D011379:Prognosis D012189:Retrospective Studies D013030:Spain D013203:Staphylococcal Infections
Joint infections Biofilms Bone infections DAIR MRSA