Polycystic ovary syndrome and mitochondrial dysfunction.
Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder of premenopausal women worldwide and is characterized by reproductive, endocrine, and metabolic abnormalities. The clinical manifestations of PCOS include oligomenorrhea or amenorrhea, hyperandrogenism, ovarian polycystic changes, and infertility. Women with PCOS are at an increased risk of suffering from type 2 diabetes; me\tabolic syndrome; cardiovascular events, such as hypertension, dyslipidemia; gynecological diseases, including infertility, endometrial dysplasia, endometrial cancer, and ovarian malignant tumors; pregnancy complications, such as premature birth, low birthweight, and eclampsia; and emotional and mental disorders in the future. Although numerous studies have focused on PCOS, the underlying pathophysiological mechanisms of this disease remain unclear. Mitochondria play a key role in energy production, and mitochondrial dysfunction at the cellular level can affect systemic metabolic balance. The recent wide acceptance of functional mitochondrial disorders as a correlated factor of numerous diseases has led to the presupposition that abnormal mitochondrial metabolic markers are associated with PCOS. Studies conducted in the past few years have confirmed that increased oxidative stress is associated with the progression and related complications of PCOS and have proven the relationship between other mitochondrial dysfunctions and PCOS. Thus, this review aims to summarize and discuss previous and recent findings concerning the relationship between mitochondrial dysfunction and PCOS.
['Zhang|Jingshun|J|http://orcid.org/0000-0002-5070-1951', 'Bao|Yigang|Y|', 'Zhou|Xu|X|', 'Zheng|Lianwen|L|']
D002318:Cardiovascular Diseases D003924:Diabetes Mellitus, Type 2 D005260:Female D006801:Humans D007246:Infertility D008928:Mitochondria D010053:Ovary D011085:Polycystic Ovary Syndrome D017697:Premenopause D012307:Risk Factors
Polycystic ovary syndrome Hyperandrogenism Oxidative stress Abnormal follicular development And inflammation Insulin resistance Obesity