Prognostic Nomogram for Overall Survival in Extranodal Natural Killer/T-Cell Lymphoma Patients.
BACKGROUND
Extranodal natural killer/T-cell lymphoma (ENKTL) is a rare lymphoid malignancy with diverse clinical features and prognoses. The aims of this study were to explore the pretreatment prognostic factors of ENKTL and develop a new individual prognostic model.


PATIENTS AND METHODS
We retrospectively enrolled 81 ENKTL patients with newly diagnosed disease between June 2006 and August 2017 at the Affiliated Cancer Hospital of Guangxi Medical University. Survival analysis was used to assess the prognostic value of various factors. A nomogram was developed to predict overall survival (OS) based on the Cox proportional hazards model.


RESULTS
The median survival time of the patients was 48 months, and the 5-year OS rate was 47.5%. Cox regression analysis showed that the prognostic factors of OS for ENKTL patients included Eastern Cooperative Oncology Group performance status, Ann Arbor stage, pretreatment albumin-to-globulin ratio, and platelet count. A prognostic nomogram was developed to predict the OS rate for ENKTL patients based on these factors. The calibration curve showed that the nomogram was able to predict OS accurately. The concordance index of the nomogram for OS prediction was 0.807.


CONCLUSION
Our proposed nomogram based on Eastern Cooperative Oncology Group performance status, Ann Arbor stage, albumin-to-globulin ratio, and platelet count provides an individualized risk estimate of OS in patients with ENKTL.
['Li|Kaiguo|K|', 'Wang|Ruyue|R|', 'Huang|Shiting|S|', 'Pan|Xinbin|X|', 'Chen|Hongmin|H|', 'Zhou|Lei|L|', 'Wei|Junbao|J|', 'Wu|Chunhua|C|', 'Zhu|Xiaodong|X|', 'Liang|Shixiong|S|', 'Qu|Song|S|']
D000293:Adolescent D000328:Adult D000368:Aged D015415:Biomarkers D005260:Female D006801:Humans D053208:Kaplan-Meier Estimate D054391:Lymphoma, Extranodal NK-T-Cell D008297:Male D008875:Middle Aged D060787:Neoplasm Grading D009362:Neoplasm Metastasis D009367:Neoplasm Staging D049451:Nomograms D011379:Prognosis D016016:Proportional Hazards Models D015203:Reproducibility of Results D012189:Retrospective Studies D055815:Young Adult
Lymphoid malignancy Prognostic model Albumin-to-globulin ratio Platelet count Calibration curve