A New Depsidone from Teloschistes flavicans and the Antileukemic Activity.
Lichens produce a variety of secondary metabolites that could be potential sources of pharmaceutically useful chemicals. However, only a limited number of lichen metabolites have been investigated for their biological significance. The objective of this study was to identify the potential compounds responsible for the antileukemic activity of lichen Teloschistes flavicans. Among three fractions (n-hexane, EtOAc, and MeOH-H2O), the ethyl acetate (EtOAc) fraction of T. flavicans methanolic extract showed the strongest inhibition in the HL-60 cell line. Additionally, the EtOAc fraction was further purified to obtain a new depsidone, 2,7-dichloro-3,8-dimethoxy-1,6,9-trimethyl-11H-dibenzo[b,e][1,4]dioxepin-11-one, named as flavicansone, along with rhizonic acid, parietin, and vicanicin. Flavicansone demonstrated the most significant inhibitory action against cell proliferation among the four isolated compounds.
['Sanjaya|Angga|A|', 'Avidlyandi|Avidlyandi|A|', 'Adfa|Morina|M|', 'Ninomiya|Masayuki|M|', 'Koketsu|Mamoru|M|']
D000972:Antineoplastic Agents, Phytogenic D001203:Ascomycota D049109:Cell Proliferation D053630:Depsides D004642:Emodin D018922:HL-60 Cells D006801:Humans D007783:Lactones D015473:Leukemia, Promyelocytic, Acute
depsidone Teloschistes flavicans antileukemic activity HL-60 cell