Effects of nanoparticles exposure and PON1 genotype on heart rate variability.
OBJECTIVES
This study was to assess the association between different NPs exposure and PON1 genotype on Heart Rate Variability (HRV) parameters among workers.


METHODS
This study included 235 non-CVD subjects handled to nanomaterials (NM) and 185 non-exposed controls without CVD from 14 NM plants. All participants completed short-term HRV measurements, and were collected blood specimens to measure PON1 activities and the genotype of the PON1 Q192R polymorphism.


RESULTS
In a multivariate regression model, this study observed a positive relationship between nano-Ag exposure and HRV time-domain (RMSSD) and frequency-domain (HF). After adjusting for confounders, the results showed positive associations between RR homozygosity, PON1 paraoxonase/arylesterase activities with HRV, and was particularly noteworthy in RMSSD and HF.


CONCLUSIONS
This study shows a significant increment of RMSSD and HF among workers who handled Nano-Ag materials. These results imply that Nano-Ag and PON1 Q192R genotype can trigger ANS reflexes and alter cardiac frequency and function.
['Wu|Wei-Te|WT|', 'Wang|Chung-Ching|CC|', 'Liou|Saou-Hsing|SH|']
D000328:Adult D043303:Aryldialkylphosphatase D016022:Case-Control Studies D005260:Female D005838:Genotype D006339:Heart Rate D006801:Humans D008297:Male D008875:Middle Aged D053758:Nanoparticles D011110:Polymorphism, Genetic
Nanoparticles Heart rate variability Nanomaterials PON1 Q192R polymorphism Paraoxonase