Molecular Insights into the Enigmatic Metabolic Regulator, SnRK1.
Sucrose non-fermenting-1 (SNF1)-related kinase 1 (SnRK1) lies at the heart of metabolic homeostasis in plants and is crucial for normal development and response to stress. Evolutionarily related to SNF1 in yeast and AMP-activated kinase (AMPK) in mammals, SnRK1 acts protectively to maintain homeostasis in the face of fluctuations in energy status. Despite a conserved function, the structure and regulation of the plant kinase differ considerably from its relatively well-understood opisthokont orthologues. In this review, we highlight the known plant-specific modes of regulation involving SnRK1 together with new insights based on a 3D molecular model of the kinase. We also summarise how these differences from other orthologues may be specific adaptations to plant metabolism, and offer insights into possible avenues of future inquiry into this enigmatic enzyme.
['Emanuelle|Shane|S|', 'Doblin|Monika S|MS|', 'Stapleton|David I|DI|', 'Bacic|Antony|A|', 'Gooley|Paul R|PR|']
D000222:Adaptation, Physiological D017360:Arabidopsis D029681:Arabidopsis Proteins D018506:Gene Expression Regulation, Plant D006706:Homeostasis D008958:Models, Molecular D010944:Plants D017346:Protein Serine-Threonine Kinases D013045:Species Specificity D013395:Sucrose
AMP-activated protein kinase (AMPK) SNF1-related kinase 1 (SnRK1) phosphorylation plant metabolic control sucrose non-fermenting 1 (SNF1) trehalose-6-phosphate (T6P)