The multifaceted role of cell cycle regulators in the coordination of growth and metabolism.
Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires a multi-directional coordination between metabolism, growth, and the cell cycle regulators (consisting of the family of cyclin-dependent kinases (CDKs), their regulatory subunits known as cyclins, CDK inhibitors, the retinoblastoma family members, and the E2F transcription factors). Deciphering the mechanisms accountable for this coordination is crucial for understanding various patho-physiological processes. While it is well established that metabolism and growth affect cell division, this review will focus on recent observations that demonstrate how cell cycle regulators coordinate metabolism, cell cycle progression, and growth. We will discuss how the cell cycle regulators directly regulate metabolic enzymes and pathways and summarize their involvement in the endolysosomal pathway and in the functions and dynamics of mitochondria.
['Huber|Katharina|K|0000-0002-4072-4877', 'Mestres-Arenas|Alberto|A|', 'Fajas|Lluis|L|0000-0002-1283-9503', 'Leal-Esteban|Lucia C|LC|0000-0002-3618-8346']
D000222:Adaptation, Physiological D000818:Animals D002453:Cell Cycle D002478:Cells, Cultured D050756:Cyclin-Dependent Kinase Inhibitor Proteins D018844:Cyclin-Dependent Kinases D016213:Cyclins D050684:E2F Transcription Factors D011992:Endosomes D005786:Gene Expression Regulation D006801:Humans D008247:Lysosomes D008928:Mitochondria D009753:Nutritive Value D047428:Protein Kinase Inhibitors D016160:Retinoblastoma Protein D012441:Saccharomyces cerevisiae D015398:Signal Transduction
cell cycle regulators metabolism endolysosomes mitochondria cell growth