Complete genome sequence of a KI polyomavirus isolated from an otherwise healthy child with severe lower respiratory tract infection.
Unbiased, deep sequencing of a nasal specimen from an otherwise healthy 13-month-old boy hospitalized in intensive care revealed high gene expression and the complete genome of a novel isolate of KI polyomavirus (KIPyV). Further investigation detected minimal gene expression of additional viruses, suggesting that KIPyV was potentially the causal agent. Analysis of the complete genome of isolate NMKI001 revealed it is different from all previously reported genomes and contains two amino acid differences as compared to the closest virus isolate, Stockholm 380 (EF127908). J. Med. Virol. 89:926-930, 2017. © 2016 Wiley Periodicals, Inc.
['Dehority|Walter N|WN|', 'Eickman|Megan M|MM|', 'Schwalm|Kurt C|KC|', 'Gross|Stephen M|SM|', 'Schroth|Gary P|GP|', 'Young|Stephen A|SA|', 'Dinwiddie|Darrell L|DL|']
D016000:Cluster Analysis D016679:Genome, Viral D059014:High-Throughput Nucleotide Sequencing D006801:Humans D007223:Infant D008297:Male D010802:Phylogeny D011120:Polyomavirus D027601:Polyomavirus Infections D012141:Respiratory Tract Infections D017422:Sequence Analysis, DNA D017385:Sequence Homology D026801:Synteny
complete genome KI polyomavirus human polyomavirus 3 next generation sequencing severe lower respiratory infection