Lactic acid 5% mouth wash vs Kenalog in Orabase 0.1% for treatment and prophylaxis of recurrent aphthous ulcer.
BACKGROUND
The outcomes of most therapeutic modalities for recurrent aphthous ulcer (RAU) are still unsatisfactory.


AIM
To evaluate lactic acid 5% mouth wash vs Kenalog in Orabase for treatment and prophylaxis of RAU.


PATIENTS/METHODS
Forty cases with early-onset idiopathic RAU were enrolled in this study. Patients were divided into two equal groups; group A patients had used Kenalog in Orabase twice daily, and group B patients had used lactic acid 5% mouth wash 3 times daily. All patients had used the therapy for 1-2 weeks according to patients' clinical response that was evaluated according to oral clinical manifestations index (OCMI); before therapy, during course of treatments and in follow-up visits.


RESULTS
At the ends of both first and second weeks, from beginning of therapy, OCMI was reduced more in group B patients than in group A with statistically significant results. These results revealed that group B achieved more reduction in the size, pain, and healing time of RAU. During the follow-up period, group A showed 40% recurrence rate while group B showed 5% only.


CONCLUSIONS
Lactic acid 5% mouth wash is natural, safe, and effective so it is better alternative to corticosteroids for treatment and prophylaxis of RAU without any side effects.
['Ibrahim|Samia A|SA|', 'Elkot|Reham A|RA|https://orcid.org/0000-0002-3998-1753', 'Soliman|Hend E|HE|']
D000328:Adult D002266:Carboxymethylcellulose Sodium D004334:Drug Administration Schedule D004338:Drug Combinations D005260:Female D005500:Follow-Up Studies D006801:Humans D019344:Lactic Acid D008297:Male D008875:Middle Aged D009067:Mouthwashes D012008:Recurrence D012720:Severity of Illness Index D013281:Stomatitis, Aphthous D016896:Treatment Outcome D014222:Triamcinolone Acetonide D055815:Young Adult
lactic acid Kenalog recurrent aphthous ulcer oral clinical manifestation index herpetiform aphthous ulceration vascular endothelial growth factor