Evidence of hypoglycemic anhedonia and modulation by bupropion in rats.
BACKGROUND
Disorders characterized by dysfunction of glucose metabolism are often comorbid with depression. The current study investigated whether a hypoglycemic state caused by 2-deoxy-d-glucose (2-DG) can result in anhedonic behaviors responsive to stimulation of monoamine activity.


METHODS
In experiment 1, male Sprague-Dawley rats were tested for maintenance of intra-oral self-administration (IOSA) of a sweet solution after pre-treatment with 300 or 500 mg/kg 2-DG, a blocker of glucose metabolism. Experiment 2 determined whether exposure to an environment previously paired with the effects of 2-DG (0, 200 or 300 mg/kg) can influence IOSA, and whether 2-DG can modify taste reactivity to same sweet solution. Finally, experiment 3 examined whether 0 or 30 mg/kg bupropion, a monoamine-reuptake blocker, would attenuate the effect of 300 mg/kg 2-DG on IOSA and taste reactivity.


RESULTS
It was found that 2-DG produced a sustained decrease in IOSA when animals were tested drug-free. This decrease in IOSA did not appear linked to place conditioning or to alterations in taste reactivity, and it was partially normalized by pre-treatment with bupropion.


CONCLUSIONS
Taken together, these results in rats suggest that rapid hypoglycemia can induce an anhedonic state characterized by impaired consummatory responses to nutritional incentive stimuli and that can be alleviated by the antidepressant bupropion.
['Horman|Thomas|T|', 'Ayoub|Samantha|S|', 'Leri|Francesco|F|']
D059445:Anhedonia D000818:Animals D018687:Antidepressive Agents, Second-Generation D001070:Appetitive Behavior D016642:Bupropion D003847:Deoxyglucose D003863:Depression D066248:High Fructose Corn Syrup D007003:Hypoglycemia D007004:Hypoglycemic Agents D008297:Male D051381:Rats D017207:Rats, Sprague-Dawley D012201:Reward D012646:Self Administration D013649:Taste
Anhedonia Bupropion 2-deoxy-d-glucose Self-administration Hypoglycemia