Injectable and thermally contractible hydroxypropyl methyl cellulose/Fe3O4 for magnetic hyperthermia ablation of tumors.
The development of efficient strategies for the magnetic hyperthermia ablation of tumors remains challenging. To overcome the significant safety limitations, we developed a thermally contractible, injectable and biodegradable material for the minimally invasive and highly efficient magnetic hyperthermia ablation of tumors. This material was composed of hydroxypropyl methyl cellulose (HPMC), polyvinyl alcohol (PVA) and Fe3O4. The thermal contractibility of HPMC/Fe3O4 was designed to avoid damaging the surrounding normal tissue upon heating, which was confirmed by visual inspection, ultrasound imaging and computed tomography (CT). The efficient injectability of HPMC/Fe3O4 was proven using a very small needle. The biosafety of HPMC/Fe3O4 was evaluated by MTT and biochemical assays as well as flow cytometry (FCM). All the aforementioned data demonstrated the safety of HPMC/Fe3O4. The results of in vitro and ex vivo experiments showed that the temperature and necrotic volume of excised bovine liver were positively correlated with the HPMC/Fe3O4 weight, iron content and heating duration. The in vivo experimental results showed that the tumors could be completely ablated using 0.06 ml of HPMC/60%Fe3O4 after 180 s of induction heating. We believe that this novel, safe and biodegradable material will promote the rapid bench-to-bed translation of magnetic hyperthermia technology, and it is also expected to bring a new concept for the biomaterial research field.
['Wang|Fengjuan|F|', 'Yang|Yang|Y|', 'Ling|Yi|Y|', 'Liu|Jianxin|J|', 'Cai|Xiaojun|X|', 'Zhou|Xiaohan|X|', 'Tang|Xiuzhen|X|', 'Liang|Bing|B|', 'Chen|Yini|Y|', 'Chen|Hangrong|H|', 'Chen|Dengming|D|', 'Li|Chunhong|C|', 'Wang|Zhigang|Z|', 'Hu|Bing|B|', 'Zheng|Yuanyi|Y|']
D000818:Animals D002417:Cattle D016923:Cell Death D045744:Cell Line, Tumor D004195:Disease Models, Animal D005260:Female D005290:Ferric Compounds D006801:Humans D006979:Hyperthermia, Induced D065347:Hypromellose Derivatives D007267:Injections D008099:Liver D060328:Magnetic Phenomena D008819:Mice, Nude D009369:Neoplasms D013696:Temperature
Thermally contractible Hydroxypropyl methyl cellulose Magnetic hyperthermia Tumor therapy