Association of a polymorphism of the interleukin 6 receptor gene with chronic kidney disease in Japanese individuals.
AIM
Various loci and genes that confer susceptibility to coronary artery disease (CAD) have been identified in Caucasian populations by genome-wide association studies (GWASs). The aim of the present study was to examine a possible association of chronic kidney disease (CKD) with 29 polymorphisms previously identified as susceptibility loci for CAD by meta-analyses of GWASs.


METHODS
The study population comprised 2247 Japanese individuals, including 1588 subjects with CKD [estimated glomerular filtration rate (eGFR) of <60 mL min(-1) 1.73 m(-2) ] and 659 controls (eGFR of ≥90 mL min(-1) 1.73 m(-2) ). The genotypes for 29 polymorphisms of 28 candidate genes were determined.


RESULTS
The χ(2) test revealed that rs4845625 (T→C) of IL6R, rs4773144 (A→G) of COL4A1, rs9319428 (G→A) of FLT1, and rs46522 (T→C) of UBE2Z were significantly (P < 0.05) related to CKD. Multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of smoking, hypertension, diabetes mellitus, and dyslipidaemia revealed that rs4845625 of IL6R (P = 0.0008; dominant model; odds ratio, 1.49), rs4773144 of COL4A1 (P = 0.0252; dominant model; odds ratio, 1.28), and rs9319428 of FLT1 (P = 0.0260: additive model; odds ratio, 0.77) were significantly associated with CKD. The serum concentration of creatinine was significantly (P = 0.0065) greater and eGFR was significantly (P = 0.0009) lower in individuals with the TC or CC genotype of IL6R than in those with the TT genotype.


CONCLUSION
The rs4845625 of IL6R may be a susceptibility locus for CKD in Japanese individuals.
['Horibe|Hideki|H|', 'Fujimaki|Tetsuo|T|', 'Oguri|Mitsutoshi|M|', 'Kato|Kimihiko|K|', 'Matsuoka|Reiko|R|', 'Abe|Shintaro|S|', 'Tokoro|Fumitaka|F|', 'Arai|Masazumi|M|', 'Noda|Toshiyuki|T|', 'Watanabe|Sachiro|S|', 'Yamada|Yoshiji|Y|']
D000368:Aged D044466:Asians D016022:Case-Control Studies D016009:Chi-Square Distribution D005260:Female D020022:Genetic Predisposition to Disease D055106:Genome-Wide Association Study D005919:Glomerular Filtration Rate D006801:Humans D007564:Japan D007668:Kidney D016015:Logistic Models D008297:Male D008875:Middle Aged D015999:Multivariate Analysis D016017:Odds Ratio D010641:Phenotype D020641:Polymorphism, Single Nucleotide D019947:Receptors, Interleukin-6 D051436:Renal Insufficiency, Chronic D012307:Risk Factors
polymorphism receptors genetics interleukin-6 kidney failure renal insufficiency