Minor triterpenes from an aqueous extract of the hook-bearing stem of Uncaria rhynchophylla.
Six new triterpenes, uncarinic acids KP (1-6), along with 24 known analogues, were isolated as minor constituents of an aqueous decoction of the hook-bearing stems of Uncaria rhynchophylla (Gou-teng). By comprehensive spectroscopic data analysis, their structures were elucidated as derivatives of olean-12-en-28-oic acid and urs-12-en-28-oic acid with different oxidized forms at C-3, C-6, and/or C-23, respectively. Cell-based preliminary bioassay showed that the (E)-/(Z)-coumaroyloxy and (E)-/(Z)-feruloyloxy units at C-27 of olean-12-en-28-oic acid and urs-12-en-28-oic acid played roles in their bioactivities.[Formula: see text].
['Li|Ruo-Fei|RF|', 'Guo|Qing-Lan|QL|', 'Zhu|Cheng-Gen|CG|', 'Xu|Cheng-Bo|CB|', 'Wei|Ya-Zi|YZ|', 'Cai|Jian|J|', 'Wang|Yue|Y|', 'Sun|Hua|H|', 'Zhang|Tian-Tai|TT|', 'Shi|Jian-Gong|JG|']
D015394:Molecular Structure D010936:Plant Extracts D014315:Triterpenes D032070:Uncaria
triterpene Uncaria rhynchophylla uncarinic acids KP Rubiaceae