Changes in the Biorhythms of Biochemical Parameters in Animals with Modeled Acute Desynchronosis.
This article describes models for the study of acute desynchronosis: jetlag syndrome and acute desynchronosis under physical stress for possible pharmacological correction of these disorders. The cosinor analysis allowed assessing significance of changes in biological rhythms in 2 biological models: the jetlag-type diurnal rhythm shift model and the model with changed light mode. The revealed changes in the rhythms of biochemical parameters in the blood serum of animals with acute desynchronosis indicate significant changes in the intensity of carbohydrate-lipid metabolism, which affected the processes of cell bioenergetics. These changes are most pronounced in the group of animals that were kept under conditions of constant darkness, which can serve as a marker of the initial stage of pathological desynchronosis. The jetlag-type model can be used to evaluate the effectiveness of the pharmacological correction of physiological desynchronosis. The model with modified light regimen can be used for evaluation of the effectiveness of pharmacological correction of pathological desynchronosis.
['Batotsyrenova|E G|EG|', 'Bakulev|S E|SE|', 'Nevzorova|T G|TG|', 'Ivanov|M B|MB|', 'Kashuro|V A|VA|', 'Zolotoverkhaja|E A|EA|', 'Kostrova|T A|TA|', 'Sharabanov|A V|AV|']
D000410:Alanine Transaminase D000418:Albumins D000818:Animals D050260:Carbohydrate Metabolism D002940:Circadian Rhythm D003404:Creatinine D003624:Darkness D007031:Hypothalamus D020179:Jet Lag Syndrome D008027:Light D050356:Lipid Metabolism D008297:Male D010507:Periodicity D051381:Rats D017208:Rats, Wistar D012984:Software D013493:Suprachiasmatic Nucleus D013997:Time Factors
biorhythms jetlag cosinor analysis desynchronosis modeling