Challenges in studying preimplantation embryo-maternal interaction in cattle.
A comprehensive understanding of the complex embryo-maternal interactions during the preimplantation period requires the analysis of the very early stages of pregnancy encompassing early embryonic development, maternal recognition and the events leading to implantation. Despite the fact that embryo development until blastocyst stage is somewhat autonomous (i.e., does not require contact with the maternal reproductive tract and can be successfully recapitulated in vitro), many studies on ruminant embryo production have focused on the fundamental question of why: (i) only 30%-40% of immature oocytes develop to the blastocyst stage and (ii) the quality of such blastocysts continually lags behind that of blastocysts produced in vivo. Clear evidence indicates that in vitro culture conditions are far from optimal with deficiencies being manifested in short- and long-term effects on the embryo. Thus, enhanced knowledge of mechanisms controlling embryo-maternal interactions would allow the design of novel strategies to improve in vitro embryo conditions and reproductive outcomes in cattle.
['Rodríguez-Alonso|Beatriz|B|', 'Sánchez|José María|JM|', 'González|Encina|E|', 'Lonergan|Patrick|P|', 'Rizos|Dimitrios|D|']
D000818:Animals D002417:Cattle D010064:Embryo Implantation D004622:Embryo, Mammalian D005187:Fallopian Tubes D005260:Female D011247:Pregnancy D014599:Uterus
Embryo-maternal interaction Embryo In vitro In vivo Oviduct Uterus