RhIII -Catalyzed Asymmetric Transfer Hydrogenation of α-Methoxy β-Ketoesters through DKR in Water: Toward a Greener Procedure.
The asymmetric reduction of α-methoxy β-ketoesters through transfer hydrogenation with a new rhodium(III) complex was developed. The reaction was efficient in 2-MeTHF with formic acid/triethylamine or in water with sodium formate. The corresponding syn α-methoxy β-hydroxyesters were obtained with high diastereoselectivities and excellent levels of enantioselectivity through a dynamic kinetic resolution process.
['He|Bin|B|', 'Zheng|Long-Sheng|LS|', 'Phansavath|Phannarath|P|http://orcid.org/0000-0002-7854-170X', 'Ratovelomanana-Vidal|Virginie|V|http://orcid.org/0000-0003-1167-1195']
water reduction asymmetric catalysis hydrogen transfer rhodium