Role of miR-146a in Enforcing Effect of Specific Immunotherapy on Allergic Rhinitis.
Allergic rhinitis (AR) is one of the common disorders in airway allergic inflammation. The pathogenesis of AR is unclear. It is accepted that immune deregulation is associated with the pathogenesis of AR. Recent reports suggest that a large number of micro RNAs (miR) can regulate immune functions. This study aims to investigate the role of miR-146a in an enforcing immunotherapy of AR. In this study, a mouse AR model was created. The levels of miR-146a in the mouse nasal mucosa were assessed by real time RT-PCR. A specific immunotherapy was performed in AR mice. The results showed that the AR mice had an AR-like inflammation in the nasal mucosa. Compared with naïve mice, markedly lower levels of miR-146a were detected in AR mice. The co-administration with miR-146a significantly enforced the effect of ovalbumin (OVA)-specific immunotherapy on inhibition of AR inflammation in the nasal mucosa. Further analysis showed that miR-146a induced transforming growth factor-β in dendritic cells; the latter induced naïve CD4(+) T cells to differentiate into regulatory T cells. In conclusion, miR-146a can enforce OVA-specific immunotherapy via inducing antigen-specific regulatory T cells. miR-146a may have therapeutic potential to be used in the immunotherapy of allergic diseases.
['Liu|Hong-Jun|HJ|', 'Zhang|Ai-Fen|AF|', 'Zhao|Na|N|', 'Li|Xue-Zhong|XZ|']
D000818:Animals D016022:Case-Control Studies D016207:Cytokines D003713:Dendritic Cells D004195:Disease Models, Animal D018984:Epitopes, T-Lymphocyte D015870:Gene Expression D006801:Humans D007073:Immunoglobulin E D007167:Immunotherapy D016219:Immunotherapy, Adoptive D018655:Lymphocyte Count D008297:Male D051379:Mice D035683:MicroRNAs D053758:Nanoparticles D009297:Nasal Mucosa D010047:Ovalbumin D065631:Rhinitis, Allergic D037182:T-Cell Antigen Receptor Specificity D016176:T-Lymphocyte Subsets D016212:Transforming Growth Factor beta D014612:Vaccines
immunotherapy micro RNA nasal mucosa Allergy vaccine