Agaricus blazei-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors: A Randomized Clinical Trial.
Since Agaricus blazei Murill (AbM) extract reduced specific IgE and ameliorated a skewed Th1/Th2 balance in a mouse allergy model, it was tested in blood donors with self-reported, IgE-positive, birch pollen allergy and/or asthma. Sixty recruited donors were randomized in a placebo-controlled, double-blinded study with pre-seasonal, 7-week, oral supplementation with the AbM-based extract AndosanTM. Before and after the pollen season, questionnaires were answered for allergic rhino-conjunctivitis, asthma, and medication; serum IgE was measured, and Bet v 1-induced basophil activation was determined by CD63 expression. The reported general allergy and asthma symptoms and medication were significantly reduced in the AbM compared to the placebo group during pollen season. During the season, there was significant reduction in specific IgE anti-Bet v 1 and anti-t3 (birch pollen extract) levels in the AbM compared with the placebo group. While the maximal allergen concentrations needed for eliciting basophil activation before the season, changed significantly in the placebo group to lower concentrations (i.e., enhanced sensitization) after the season, these concentrations remained similar in the AndosanTM AbM extract group. Hence, the prophylactic effect of oral supplementation before the season with the AbM-based AndosanTM extract on aeroallergen-induced allergy was associated with reduced specific IgE levels during the season and basophils becoming less sensitive to allergen activation.
['Mahmood|Faiza|F|', 'Hetland|Geir|G|0000-0003-1272-3436', 'Nentwich|Ivo|I|', 'Mirlashari|Mohammad Reza|MR|', 'Ghiasvand|Reza|R|', 'Nissen-Meyer|Lise Sofie Haug|LSH|']
D000284:Administration, Oral D000328:Adult D000364:Agaricus D018926:Anti-Allergic Agents D001491:Basophils D029662:Betula D001782:Blood Donors D045424:Complex Mixtures D003233:Conjunctivitis, Allergic D004311:Double-Blind Method D005260:Female D006801:Humans D007073:Immunoglobulin E D008297:Male D008875:Middle Aged D009664:Norway D010936:Plant Extracts D011058:Pollen D006255:Rhinitis, Allergic, Seasonal D013997:Time Factors D016896:Treatment Outcome D055815:Young Adult
clinical trial birch pollen allergy asthma AndosanTM basophil activation Agaricus blazei mushroom