Association of ABCB1 polymorphisms with lipid homeostasis and liver injury response to atorvastatin in the Chinese population.
The present research was to assess the relationship between ABCB1 (G2677T/A, C3435T) polymorphisms and lipid homeostasis as well as risk of liver injury induced by atorvastatin in in-patients from China. The lipid levels (total cholesterol, high-density lipoprotein, triglycerides) as well as metabolic enzymes of hepar (glutamic-pyruvic transaminase, glutamic-oxalacetic transaminase, alkaline phosphatase, γ-glutamyl transpeptidase) in plasma for 162 patients were measured at baseline and after approximately 6 months of atorvastatin treatment. Polymorphisms of the ABCB1 gene were determined using the Snapshot technique. The associations between genetic polymorphisms and lipid levels as well as hepar indexes were evaluated at the end of medical treatment. Based on one-way ANOVA analysis, patients with the 2677GG or 3435TT genotypes showed a remarkable decrease in percentage when the level of TC was above 4.00 mmol·L-1, separately (P < 0.05). There was a significant decrease in percentage in the frequency of patients with the 2677GG genotype (low-density lipoprotein > 2.00 mmol·L-1) (P < 0.05). The level of glutamic-pyruvic transaminase in patients with the 2677GG or 3435CC genotype displayed a significantly increase in percentage, respectively (P < 0.05). The ABCB1 G-C haplotype carriers were associated with an increased risk of AILI. The results provide evidence for clinically individualised utilisation of atorvastatin for lipid homeostasis as well as risk of induced liver injury in the Chinese population.
['Qu|Kan-Kan|KK|', 'Zhang|Chen-Ning|CN|', 'Dong|Li-Xia|LX|', 'Wang|Shu-Shan|SS|', 'Zhang|Zhong-Dong|ZD|', 'Zhang|Lin|L|']
D018435:ATP Binding Cassette Transporter, Subfamily B D000368:Aged D044466:Asians D000069059:Atorvastatin D002784:Cholesterol D005260:Female D005838:Genotype D006706:Homeostasis D006801:Humans D050356:Lipid Metabolism D008075:Lipoproteins, HDL D008077:Lipoproteins, LDL D008099:Liver D008297:Male D020641:Polymorphism, Single Nucleotide D000637:Transaminases D014280:Triglycerides
ABCB1 polymorphisms lipid homeostasis atorvastatin atorvastatin Chinese population risk of liver injury atorvastatine homéostasie des lipids polymorphismes du gène ABCB1 population chinoise risque de lésions hépatiques