Genetic variation in EYA4 on the risk of noise-induced hearing loss in Chinese steelworks firm sample.
OBJECTIVES
Noise-induced hearing loss is one of the most serious occupational diseases worldwide. It is caused by interactions between environmental and genetic factors. The purpose of this study was to examine the association between the genetic susceptibility of the eye absent homolog 4 (EYA4) gene and the risk of developing noise-induced hearing loss in China.


METHODS
A case-control association study was carried out with 326 hearing loss cases and 326 controls matched with age and duration of noise exposure, drawn from a cohort of steel workers. Five single nucleotide polymorphisms (SNPs) in the EYA4 were selected and genotyped. Logistic regression was performed to analyse the main effect of genotypes and interactions between genotypes and individual/environmental factors adjusted for confounding factors. Moreover, generalised multiple dimensionality reduction was applied to further detect interaction among the 5 selected SNPs.


RESULTS
Analysis revealed that locus polymorphism of rs3813346 was associated with the risk of developing noise-induced hearing loss in the dominance model, the codominance model and the addictive model (p=0.004, 0.009 and 0.003, respectively). A significant interaction between rs9321402 and cumulative noise exposure was found (p=0.002). A significant main effect p value (p=0.006) was obtained in the high-level exposure group (cumulative noise exposure ≥98 dB(A)). Generalised multiple dimensionality reduction indicated that the combined interaction of the 2 loci-rs3813346 and rs9493627-significantly affected the incidence of noise-induced hearing loss.


CONCLUSIONS
The research suggests that EYA4 genetic variant and its interaction with noise levels may modify the susceptibility to develop noise-induced hearing loss in Chinese population.
['Yang|Qiuyue|Q|', 'Xu|Xiangrong|X|', 'Jiao|Jie|J|', 'Zheng|Yuxin|Y|', 'He|Lihua|L|', 'Yu|Shanfa|S|', 'Gu|Guizhen|G|', 'Chen|Guoshun|G|', 'Zhou|Wenhui|W|', 'Wu|Hui|H|', 'Li|Yanhong|Y|', 'Zhang|Huanling|H|', 'Zhang|Zengrui|Z|']
D000328:Adult D001299:Audiometry D016022:Case-Control Studies D002681:China D020022:Genetic Predisposition to Disease D005838:Genotype D006317:Hearing Loss, Noise-Induced D006801:Humans D016015:Logistic Models D008297:Male D000072499:Manufacturing and Industrial Facilities D008875:Middle Aged D009623:Noise, Occupational D009784:Occupational Diseases D016273:Occupational Exposure D011110:Polymorphism, Genetic D012307:Risk Factors D013232:Steel D015534:Trans-Activators
Noise-Induced Hearing Loss EYA4 gene Genetic Variability