Comparison between wide-angle OCT angiography and ultra-wide field fluorescein angiography for detecting non-perfusion areas and retinal neovascularization in eyes with diabetic retinopathy.
PURPOSE
To compare the ability of wide-angle optical coherence tomography angiography (OCTA) with that of ultra-wide field fluorescein angiography (UWFFA) to detect non-perfusion areas (NPAs) or retinal neovascularization (NV) in eyes with diabetic retinopathy (DR).


METHODS
Patients with DR underwent UWFFA using the Optos® panoramic 200Tx imaging system and wide-angle OCTA with 12 × 12 mm fields of five visual fixations using the PLEX Elite 9000®. We compared the abilities of UWFFA and OCTA to detect NPAs and NV.


RESULTS
Fifty-eight eyes of 33 patients (mean age, 60.0 years old; female/male, 16/17) with DR were evaluated. NPAs were detected in 47 out of 58 eyes using UWFFA and in 48 eyes using OCTA. NVs were detected in 25 out of the 58 eyes using UWFFA and in 26 eyes using OCTA. The sensitivity for detection of NPA using OCTA was 0.98, and the specificity was 0.82. The sensitivity for detection of NV was 1.0, and the specificity was 0.97.


CONCLUSION
The wide-angle OCTA seems to be clinically useful for the detection of NPAs or NV.
['Sawada|Osamu|O|http://orcid.org/0000-0001-9752-0499', 'Ichiyama|Yusuke|Y|', 'Obata|Syunpei|S|', 'Ito|Yuka|Y|', 'Kakinoki|Masashi|M|', 'Sawada|Tomoko|T|', 'Saishin|Yoshitsugu|Y|', 'Ohji|Masahito|M|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D003930:Diabetic Retinopathy D005260:Female D005451:Fluorescein Angiography D005654:Fundus Oculi D006801:Humans D021621:Imaging, Three-Dimensional D008297:Male D008875:Middle Aged D012372:ROC Curve D015861:Retinal Neovascularization D012171:Retinal Vessels D041623:Tomography, Optical Coherence
Fluorescein angiography Non-perfusion area Retinal neovascularization Diabetic retinopathy Ocular coherence tomography angiography