Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer.
Recurrence of colorectal cancer (CRC) following a potentially curative resection is a challenging clinical problem. Matrix metalloproteinase-7 (MMP-7) is over-expressed by CRC cells and supposed to play a major role in CRC cell diffusion and metastasis. MMP-7 RNA expression was assessed by real-time PCR using specific primers in peritoneal washing fluid obtained during surgical procedure. After surgery, patients underwent a regular follow up for assessing recurrence. transcripts for MMP-7 were detected in 31/57 samples (54%). Patients were followed-up (range 20-48 months) for recurrence prevention. Recurrence was diagnosed in 6 out of 55 patients (11%) and two patients eventually died because of this. Notably, all the six patients who had relapsed were positive for MMP-7. Sensitivity and specificity of the test were 100% and 49% respectively. Data from patients have also been corroborated by computational approaches. Public available coloncarcinoma datasets have been employed to confirm MMP7 clinical impact on the disease. Interestingly, MMP-7 expression appeared correlated to Tgfb-1, and correlation of the two factors represented a poor prognostic factor. This study proposes positivity of MMP-7 in peritoneal cavity as a novel biomarker for predicting disease recurrence in patients with CRC.
['Sica|Giuseppe S|GS|', 'Fiorani|Cristina|C|', 'Stolfi|Carmine|C|', 'Monteleone|Giovanni|G|', 'Candi|Eleonora|E|', 'Amelio|Ivano|I|', 'Catani|Valeria|V|', 'Sibio|Simone|S|', 'Divizia|Andrea|A|', 'Tema|Giorgia|G|', 'Iaculli|Edoardo|E|', 'Gaspari|Achille L|AL|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D014408:Biomarkers, Tumor D015179:Colorectal Neoplasms D005260:Female D006801:Humans D008297:Male D020783:Matrix Metalloproteinase 7 D008875:Middle Aged D009364:Neoplasm Recurrence, Local D010537:Peritoneum D011184:Postoperative Period D011379:Prognosis
MMP7 colorectal carcinoma