Morphologic and functional abnormalities in patients with Ebstein's anomaly with cardiac magnetic resonance imaging: Correlation with tricuspid regurgitation.
PURPOSE
The aim of this study was to assess the correlations of functional and dimensional parameters with the severity of tricuspid regurgitation in patients with Ebstein's anomaly (EA) by using cardiac magnetic resonance (CMR) imaging.


MATERIALS AND METHODS
Thirty-three patients with EA without previous cardiac surgery and 25 normal individuals were recruited and underwent both cardiac MR imaging and preoperative transthoracic echocardiography. The left ventricular (LV) functional parameters and dimensions of the right ventricle (RV) and LV were measured using 3.0-T cardiac MR imaging. Tricuspid regurgitation severity grading was estimated by echocardiography. The functional and dimensional parameters were compared between EA patients and controls using independent sample t-tests. Spearman's rank correlation was used to determine the correlations between the functional and dimensional parameters and tricuspid regurgitation. Receiver operating characteristic (ROC) analysis was used to predict tricuspid regurgitation severity using individual functional and dimensional parameters.


RESULTS
Statistical analysis revealed significant differences in the functional and dimensional parameters between EA patients and controls. Within the EA group, tricuspid valve regurgitation negatively correlated well with the left ventricular ejection fraction (LVEF) (r=-0.558, p=0.001). The ratio of the right ventricular (functional right ventricle) end-diastolic dimension to the left ventricle end-diastolic dimension (RVEDD/LVEDD) in EA patients also correlated well with the severity of tricuspid valve regurgitation (r=0.492, p=0.004). Moreover, ROC analysis revealed that high sensitivity and specificity were obtained for predicting the severity of tricuspid valve regurgitation with LVEF (78.3%, 90.0%) and RVEDD/LVEDD (78.3%, 94.3%).


CONCLUSION
In EA patients, the left and right ventricular functional and dimensional parameters from MRI correlated well with tricuspid regurgitation, which helped predict the severity of EA.
['Liu|Xi|X|', 'Zhang|Qin|Q|', 'Yang|Zhi-Gang|ZG|', 'Guo|Ying-Kun|YK|', 'Shi|Ke|K|', 'Xu|Hua-Yan|HY|', 'Wen|Ling-Yi|LY|', 'Li|Rui|R|', 'Chen|Jing|J|']
D000328:Adult D006348:Cardiac Surgical Procedures D004437:Ebstein Anomaly D004452:Echocardiography D005260:Female D006352:Heart Ventricles D006801:Humans D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D011446:Prospective Studies D012372:ROC Curve D014262:Tricuspid Valve Insufficiency D016277:Ventricular Function, Left
Cardiac magnetic resonance Tricuspid regurgitation LVEF Ebstein’s anomaly