Potential neuroinvasive and neurotrophic properties of SARS-CoV-2 in pediatric patients: comparison of SARS-CoV-2 with non-segmented RNA viruses.
The emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing global health crises. Children can be infected, but are less likely to develop severe neurological abnormalities compared with adults. However, whether SARS-CoV-2 can directly cause neurological impairments in pediatric patients is not known. The possible evolutionary and molecular relationship between SARS-CoV-2 and non-segmented RNA viruses were examined with reference to neurological disorders in pediatric patients. SARS-CoV-2 shares similar functional domains with neuroinvasive and neurotropic RNA viruses. The Spike 1 (S1) receptor binding domain and the cleavage sites at S1/S2 boundary are less conserved compared with the S2 among coronaviruses.
['Chen|Xiaodi|X|0000-0002-1860-2814']
D000086382:COVID-19 D002648:Child D002675:Child, Preschool D019295:Computational Biology D005260:Female D006801:Humans D007223:Infant D008297:Male D009422:Nervous System Diseases D010802:Phylogeny D012328:RNA Viruses D000086402:SARS-CoV-2 D064370:Spike Glycoprotein, Coronavirus D014774:Virulence
Pediatric patients Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Conserved domain Genome Multiple sequence alignment Neuroinvasive and neurotrophic non-segmented RNA viruses Phylogenetic tree Spike protein