Controlled release of folic acid through liquid-crystalline folate nanoparticles.
The present study explores folate nanoparticles as nano-carriers for controlled drug delivery. Cross-linked nanoparticles of liquid crystalline folates are composed of ordered stacks. This paper shows that the folate nanoparticles can be made with less than 5% loss in folate ions. In addition, this study shows that folate nanoparticles can disintegrate in a controlled fashion resulting in controlled release of the folate ions. Release can be controlled by the size of nanoparticles, the extent of cross-linking and the choice of cross-linking cation. The effect of different factors like agitation, pH, and temperature on folate release was also studied. Studies were also carried out to show the effect of release medium and role of ions in the release medium on disruption of folate assembly.
['Misra|Rahul|R|', 'Katyal|Henna|H|', 'Mohanty|Sanat|S|']
D003692:Delayed-Action Preparations D004337:Drug Carriers D005492:Folic Acid D006367:HeLa Cells D006801:Humans D006863:Hydrogen-Ion Concentration D008855:Microscopy, Electron, Scanning D046529:Microscopy, Electron, Transmission D053758:Nanoparticles D010316:Particle Size
Control release Folates Nanoparticles Cross-linking Chromonics