Pulse pressure does not predict the response of diabetic nephropathy to glucose-lowering therapy.
We aimed to study whether pulse pressure (PP) predicts the response of diabetic nephropathy to glucose-lowering treatment. Patients with uncontrolled type 2 diabetes were followed for decrease in albuminuria after insulin/oral-hypoglycemic treatment. A total of 143 patients were followed for a median time of 10.5 months in a cohort study. Fasting blood sugar and HbA1C significantly decreased, while systolic, diastolic and pulse pressures remained constant during intervention. Median albuminuria decreased from 18.4 mg/day [10-40] to 16.4 mg/day [9-28] at the end of study (p-value < 0.005). The number of patients with normo/micro/macro-albuminuria changed from 98/36/9 to 108/31/4 (p-value < 0.001). No significant difference in baseline PP (47.5 ± 1.61 vs. 45.9 ± 1.81 mmHg; p-value = 0.51) or final PP (47.0 ± 2.41 vs. 49.4 ± 2.38 mmHg; p-value = 0.47) existed between those with decreased and increased albuminuria. PP was not a significant predictor of albuminuria changes in receiver operating characteristic curve (p-value = 0.77) and regression (p-value = 0.98) analyses. Benefits of glycemic control in diabetic nephropathy are independent of PP.
['Nakhjavani|Manouchehr|M|', 'Nargesi|Arash Aghajani|AA|', 'Heidari|Behnam|B|', 'Ghazizadeh|Zaniar|Z|', 'Larry|Mehrdad|M|', 'Esteghamati|Alireza|A|']
D000419:Albuminuria D019540:Area Under Curve D015415:Biomarkers D001786:Blood Glucose D001794:Blood Pressure D003924:Diabetes Mellitus, Type 2 D003928:Diabetic Nephropathies D015536:Down-Regulation D005260:Female D006801:Humans D007004:Hypoglycemic Agents D008297:Male D008875:Middle Aged D011237:Predictive Value of Tests D012372:ROC Curve D012307:Risk Factors D013997:Time Factors D016896:Treatment Outcome
Pulse pressure nephropathy type 2 diabetes albuminuria