Protein Acetylation and Its Role in Bacterial Virulence.
Protein acetylation is a universal post-translational modification which is found in both eukaryotes and prokaryotes. This process is achieved enzymatically by the protein acetyltransferase Pat, and nonenzymatically by metabolic intermediates (e.g., acetyl phosphate) in bacteria. Protein acetylation plays a role in bacterial chemotaxis, metabolism, DNA replication, and other cellular processes. Recently, accumulating evidence has suggested that protein acetylation might be involved in bacterial virulence because a number of bacterial virulence factors are acetylated. In this review, we summarize the progress in understanding bacterial protein acetylation and discuss how it mediates bacterial virulence.
['Ren|Jie|J|', 'Sang|Yu|Y|', 'Lu|Jie|J|', 'Yao|Yu-Feng|YF|']
D000107:Acetylation D000123:Acetyltransferases D001419:Bacteria D001426:Bacterial Proteins D002244:Carbon D009584:Nitrogen D011499:Protein Processing, Post-Translational D011506:Proteins D040901:Proteomics D014774:Virulence
protein acetylation virulence bacteria