Senescent B cells in aging and age-related diseases: Their role in the regulation of antibody responses.
Immune cells with a senescence-associated secretory phenotype increase in the blood of elderly individuals or individuals with age-associated diseases or with infections. Although senescent immune cells do not proliferate, they are transcriptionally and metabolically active and affect the microenvironment through the secretion of pro-inflammatory mediators. An age-driven increase in senescent B, T and NK cells has been reported and the function of these cells has been characterized. Results published by different groups have demonstrated that cell senescence induces the accumulation of terminally-differentiated cells characterized by the arrest of cell proliferation but with an active secretory profile which regulates their function through the activation of pathways integrating senescence and energy-sensing signals. This review will focus on senescent B cells, their increase in aging, age-associated conditions and infections. Similarities with other senescent immune cells will be presented and discussed.
['Frasca|Daniela|D|']
D000368:Aged D000375:Aging D000917:Antibody Formation D001402:B-Lymphocytes D001692:Biological Transport D049109:Cell Proliferation D016922:Cellular Senescence D006801:Humans D007694:Killer Cells, Natural
B cells Antibody responses Cell senescence Inflammation