The effects of previous statin treatment on plasma matrix metalloproteinase-9 level in Chinese stroke patients undergoing thrombolysis.
It is unclear whether previous statin therapy influences the prognosis, hemorrhagic transformation, and plasma matrix metalloproteinases (MMP)-9 levels in Chinese stroke patients receiving intravenous thrombolysis. We conduct a prospective cohort study of 193 patients treated with intravenous thrombolysis. All the enrolled patients were divided into 2 groups (the control group and the statin group), according to the previous history of statin use. The plasma MMP-9 levels were detected before and at 6 hours, 12 hours, 24 hours, and 72 hours after intravenous thrombolysis. The clinical outcome of stroke was measured in terms of the functional outcome and occurrence of symptomatic intracerebral hemorrhage. The MMP-9 levels increased after thrombolysis in statin group and control group. No significant intergroup difference was found in the MMP-9 levels before and at 6 hours after thrombolysis, but the levels were significantly lower in the statin group than in the control group at 12, 24, and 72 hours (P < .001) after thrombolysis. Similarly, no significant intergroup difference was noted in the occurrence of symptomatic intracranial hemorrhage as was the case with the modified Rankin scale (assessed by the Mann-Whitney U test) at 7 days (P = .428) and 90 days (P = .419) after thrombolysis. Our results indicate that pretreatment with statin can inhibit the thrombolysis-induced increase in plasma MMP-9 levels but does not significantly affect the prognosis of acute ischemic stroke patients undergoing intravenous thrombolysis.
['Zhao|Hong-Dong|HD|', 'Zhang|Ying-Dong|YD|']
D061605:Administration, Intravenous D000368:Aged D044466:Asians D015415:Biomarkers D002681:China D005260:Female D005343:Fibrinolytic Agents D006801:Humans D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors D020300:Intracranial Hemorrhages D008297:Male D020780:Matrix Metalloproteinase 9 D008875:Middle Aged D011446:Prospective Studies D020521:Stroke D015912:Thrombolytic Therapy D013997:Time Factors D016896:Treatment Outcome
statin matrix metalloproteinase-9 thrombolysis prognosis Ischemic stroke prospective clinical cohort study