Transcatheter aortic valve implantation in patients with a reduced left ventricular ejection fraction: a single-centre experience in 2000 patients (TAVIK Registry).
BACKGROUND
Previous studies into the effect of a reduced left ventricular ejection fraction (EF) on the short- and long-term prognosis of patients undergoing transcatheter aortic valve implantation (TAVI) have reported conflicting findings. We analysed data from the Karlsruhe TAVI registry with the aim of addressing this question.


METHODS AND RESULTS
Patients with aortic stenosis undergoing TAVI were divided into sub-groups according to EF: severely reduced (<30%; n = 109), reduced (≥30 and ≤40%; n = 201), and mid-range/preserved (>40%; n = 1690). VARC complications at 30 days for the population with severely reduced EF did not differ in comparison to the patients with mid-range/preserved EF. Patients with severely reduced EF had a significantly lower survival at 48 h (91.7 vs. 99.0%; p < 0.001), at 30 days (84.4 vs. 95.8%; p < 0.001) and at 1 year (66.1 vs. 85.0%, p < 0.001) compared to those with mid-range/preserved EF. The risk of death increased with age, peripheral arterial disease, poor self-care and chronic renal failure in patients with severely reduced EF.


CONCLUSIONS
Mortality post-TAVI was higher for patients with a reduced EF, although the excess comorbidity burden likely contributed to this. A reduced EF should not be considered a contraindication for TAVI per se, but the additional presence of comorbidity indicates increased risk for these patients.
['Schymik|Gerhard|G|', 'Tzamalis|Panagiotis|P|', 'Herzberger|Valentin|V|', 'Bergmann|Jens|J|', 'Bramlage|Peter|P|', 'Würth|Alexander|A|', 'Conzelmann|Lars Oliver|LO|', 'Luik|Armin|A|', 'Schröfel|Holger|H|']
D000368:Aged D000369:Aged, 80 and over D001021:Aortic Valve D001024:Aortic Valve Stenosis D017548:Echocardiography, Transesophageal D005260:Female D005500:Follow-Up Studies D006350:Heart Valve Prosthesis D006801:Humans D008297:Male D011379:Prognosis D011446:Prospective Studies D012042:Registries D012307:Risk Factors D012720:Severity of Illness Index D013997:Time Factors D014057:Tomography, X-Ray Computed D065467:Transcatheter Aortic Valve Replacement D018487:Ventricular Dysfunction, Left D016277:Ventricular Function, Left
Ejection fraction TAVI Aortic stenosis Risk Mortality Surgery