A novel four- and pseudo-five-component reaction: unexpected efficient one-pot synthesis of 4H-thiopyran derivatives.
A facile and convenient novel method is reported for the synthesis of substituted 4H-thiopyrans by reacting aldehydes, malononitrile, carbon disulfide, and primary amines at room temperature in the presence of triethylamine as a catalyst. This reaction affords the desired products in high purity and has advantages of excellent yields, simple work-up procedure, and short reaction time.
['Mobinikhaledi|Akbar|A|', 'Bodaghifard|Mohammad Ali|MA|', 'Asadbegi|Sajad|S|']
D000447:Aldehydes D002246:Carbon Disulfide D002384:Catalysis D060326:Chemistry Techniques, Synthetic D005021:Ethylamines D009570:Nitriles D011714:Pyrans D013438:Sulfhydryl Compounds D013696:Temperature
Isothiocyanate MCR Michael addition Multicomponent reaction One-pot reaction Thiopyrans