Current practices in the management of adenovirus infection in allogeneic hematopoietic stem cell transplant recipients in Europe: The AdVance study.
OBJECTIVE
Adenovirus (AdV) infections are potentially life-threatening for allogeneic hematopoietic stem cell transplant (allo-HCT) recipients. The AdVance study aimed to evaluate the incidence, management, and outcomes of AdV infections in European allo-HCT recipients.


METHODS
As part of the study, physician surveys were conducted to determine current AdV screening and treatment practices at their center.


RESULTS
All of the 28 respondents who treat pediatric patients reported routine AdV screening practices, with 93% screening all allo-HCT recipients and others screening those with transplant-related risk factors. Nearly all centers take a pre-emptive approach to AdV treatment in both high- (89%) and low-risk patients (75%). Among the 14 respondents who treat adult patients, 5 (36%) reported routine screening practices and few (21%) screen all allo-HCT recipients unless risk factors are present. In adults, pre-emptive AdV treatment is uncommon and quantitative AdV thresholds are rare. Typical treatment for all patients with symptomatic AdV infection is off-label intravenous cidofovir.


CONCLUSIONS
Our findings confirm that screening for AdV is more common in pediatric patients. Antiviral treatment is employed in both pediatric and adult patients, although adults are generally treated when AdV disease is diagnosed. The approach to AdV screening and treatment is risk-based and consistent with clinical guidelines.
['González-Vicent|Marta|M|', 'Verna|Marta|M|', 'Pochon|Cécile|C|', 'Chandak|Aastha|A|', 'Vainorius|Enrikas|E|', 'Brundage|Tom|T|', 'Mozaffari|Essy|E|', 'Nichols|Garrett|G|', 'Rao|Kanchan|K|']
D000257:Adenoviridae Infections D000998:Antiviral Agents D003955:Diagnostic Tests, Routine D019468:Disease Management D005060:Europe D019538:Health Care Surveys D018380:Hematopoietic Stem Cell Transplantation D006801:Humans D000072143:Pediatricians D010818:Practice Patterns, Physicians' D014184:Transplantation, Homologous D016896:Treatment Outcome
transplantation DNA viruses adenoviridae antiviral agents infection control virus diseases