A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism.
The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer. The review was performed on available studies on genetic polymorphisms and head and neck cancer (HNC) published in PubMed up to September 2011. 246 primary articles and 7 meta-analyses were published. Among these, a statistically significant association was reported for glutathione S-transferases (GSTM1), glutathione S-transferases (GSTT1) and human microsomal epoxide hydrolase (EPHX1) genes. An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).
['Cadoni|G|G|', 'Boccia|S|S|', 'Petrelli|L|L|', 'Di Giannantonio|P|P|', 'Arzani|D|D|', 'Giorgio|A|A|', 'De Feo|E|E|', 'Pandolfini|M|M|', 'Gallì|P|P|', 'Paludetti|G|G|', 'Ricciardi|G|G|']
D059447:Cell Cycle Checkpoints D000431:Ethanol D006258:Head and Neck Neoplasms D006801:Humans D008660:Metabolism D017720:Molecular Epidemiology D011110:Polymorphism, Genetic
Head and neck cancer Genetic polymorphisms Genetic susceptibility