The cytotoxicity of 8-O-4' neolignans from the seeds of Crataegus pinnatifida.
Nine new 8-O-4' neolignans, named pinnatifidanin B I-IX (1-9), together with 9 known analogs (10-18) were isolated from the seeds of Crataegus pinnatifida. The structures of 1-18 were determined by spectroscopic methods, including 1D, 2D NMR, CD and HRESIMS analysis. Compounds 8-11, 17 and 18 displayed potent cytotoxic activities against human cancer cell lines, and most interestingly, none of the 6 compounds displayed inhibitory activity against human lung cell line (Mrc5). The 6 cytotoxic compounds are considered to be potential as antitumor agents, which could significantly inhibit the cancer cell growth in a dose-dependent manner and are probably safer than positive control drug.
['Huang|Xiao-Xiao|XX|', 'Zhou|Chen-Chen|CC|', 'Li|Ling-Zhi|LZ|', 'Li|Fei-Fei|FF|', 'Lou|Li-Li|LL|', 'Li|Dian-Ming|DM|', 'Ikejima|Takshi|T|', 'Peng|Ying|Y|', 'Song|Shao-Jiang|SJ|']
D000972:Antineoplastic Agents, Phytogenic D045744:Cell Line, Tumor D002470:Cell Survival D002942:Circular Dichroism D027825:Crataegus D004354:Drug Screening Assays, Antitumor D006801:Humans D017705:Lignans D009682:Magnetic Resonance Spectroscopy D008968:Molecular Conformation D012639:Seeds
Cytotoxicities Crataegus pinnatifida 8-O-4′ Neolignans