Phenolic-rich smoothie consumption ameliorates non-alcoholic fatty liver disease in obesity mice by increasing antioxidant response.
Consumption of foods rich in phenolic compounds can be beneficial for health. This study aimed to examine whether the consumption of a phenolic-rich smoothie, based on juçara, strawberry and banana, ameliorates metabolic status and liver damage of diet-induced obese mice. Forty male C57BL/6J mice were assigned into four groups (n = 10) and fed control diet with free access to water (C) or phenolic-rich smoothie (C-S), or fed high-fat diet with free access to water (HF) or phenolic-rich smoothie (HF-S) for five weeks. HF and HF-S groups had higher body weight gains than the C group, however the HF had a greater adipose index, higher plasma levels of glucose, insulin and leptin, as well as higher plasma and hepatic steatosis than C, C-S and HF-S groups. The liver oxidative stress markers were reduced in C-S and HF-S groups and the activity of catalase and glutathione peroxidase were higher compared with their counterparts. The present study suggests that regular consumption of a phenolic-rich smoothie improves the liver antioxidant status, prevents metabolic disorders and ameliorates non-alcoholic fatty liver disease caused by high-fat diet consumption.
['Quitete|Fernanda Torres|FT|', 'Almeida Santos|Giulia Medeiros|GM|', 'de Oliveira Ribeiro|Leilson|L|', 'Aguiar da Costa|Cristiane|C|', 'Freitas|Suely Pereira|SP|', 'Martins da Matta|Virgínia|V|', 'Daleprane|Julio Beltrame|JB|']
D000818:Animals D000975:Antioxidants D059305:Diet, High-Fat D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D008820:Mice, Obese D065626:Non-alcoholic Fatty Liver Disease D009765:Obesity D010636:Phenols
Obesity Phenolic compounds Adipose tissue Antioxidant capacity Liver steatosis Tropical fruit