The Story of MCF-7 Breast Cancer Cell Line: 40 years of Experience in Research.
Breast cancer is the most frequent malignancy in females. Due to its major impact on population, this disease represents a critical public health problem that requires further research at the molecular level in order to define its prognosis and specific treatment. Basic research is required to accomplish this task and this involves cell lines as they can be widely used in many aspects of laboratory research and, particularly, as in vitro models in cancer research. MCF-7 is a commonly used breast cancer cell line, that has been promoted for more than 40 years by multiple research groups but its characteristics have never been gathered in a consistent review article. The current paper provides a broad description of the MCF-7 cell line, including the molecular profile, proliferation, migration, invasion, spheroid formation, its involvement in angiogenesis and lymphangiogenesis and its interaction with the mesenchymal stem cells.
['Comşa|Şerban|Ş|', 'Cîmpean|Anca Maria|AM|', 'Raica|Marius|M|']
D001943:Breast Neoplasms D049109:Cell Proliferation D005260:Female D015972:Gene Expression Regulation, Neoplastic D006801:Humans D061986:MCF-7 Cells D014411:Neoplastic Stem Cells
MCF-7 breast cancer review angiogenesis lymphangiogenesis mesenchymal stem cells