Vectorial Catalysis in Surface-Anchored Nanometer-Sized Metal-Organic Frameworks-Based Microfluidic Devices.
Vectorial catalysis-controlling multi-step reactions in a programmed sequence and by defined spatial localization in a microscale device-is an enticing goal in bio-inspired catalysis research. However, translating concepts from natural cascade biocatalysis into artificial hierarchical chemical systems remains a challenge. Herein, we demonstrate integration of two different surface-anchored nanometer-sized metal-organic frameworks (MOFs) in a microfluidic device for modelling vectorial catalysis. Catalyst immobilization at defined sections along the microchannel and a two-step cascade reaction was conducted with full conversion after 30 seconds and high turnover frequencies (TOF≈105  h-1 ).
['Semrau|Anna Lisa|AL|http://orcid.org/0000-0001-7087-932X', 'Stanley|Philip M|PM|http://orcid.org/0000-0002-1951-4074', 'Huber|Dominik|D|http://orcid.org/0000-0003-1808-1198', 'Schuster|Michael|M|', 'Albada|Bauke|B|http://orcid.org/0000-0003-3659-2434', 'Zuilhof|Han|H|http://orcid.org/0000-0001-5773-8506', 'Cokoja|Mirza|M|http://orcid.org/0000-0003-3144-4678', 'Fischer|Roland A|RA|http://orcid.org/0000-0002-7532-5286']
Vectorial catalysis Catalysis Microfluidic devices Metal-organic frameworks Surface anchoring