Eugenia punicifolia (Kunth) DC. as an adjuvant treatment for type-2 diabetes mellitus: a non-controlled, pilot study.
Type-2 diabetes mellitus (DM) is a highly prevalent disease with significant morbidity and mortality around the world. However, there is no universally effective treatment, because response to different treatment regimens can vary widely among patients. In this study, we aimed to investigate whether the use of the powdered dried leaves of Eugenia punicifolia (Kunth) DC. (Myrtaceae) is effective as an adjuvant to the treatment of patients with type-2 DM. Fifteen patients were enrolled in a pilot, non-controlled study, and received E. punicifolia for 3 months. After treatment, we observed a significant decrease in glycosylated hemoglobin, basal insulin, thyroid-stimulating hormone, C-reactive protein, and both systolic and diastolic blood pressure. There were no changes in fasting and postprandial glycemia. The compounds myricetin-3-O-rhamnoside, quercetin-3-O-galactoside, quercetin-3-O-xyloside, quercetin-3-O-rhamnoside, kaempferol-3-O-rhamnoside, phytol, gallic acid, and trans-caryophyllene present in the powdered dried leaves of E. punicifolia may be responsible for the therapeutic effect. In conclusion, the powdered leaves of E. punicifolia are promising as an adjuvant in the treatment of type-2 DM and deserve further investigation.
['Sales|Débora Simone|DS|', 'Carmona|Fabio|F|', 'de Azevedo|Bruna Cestari|BC|', 'Taleb-Contini|Silvia Helena|SH|', 'Bartolomeu|Ana Carolina Duó|AC|', 'Honorato|Fernando B|FB|', 'Martinez|Edson Z|EZ|', 'Pereira|Ana Maria Soares|AM|']
D000368:Aged D001786:Blood Glucose D002097:C-Reactive Protein D003924:Diabetes Mellitus, Type 2 D005260:Female D006442:Glycated Hemoglobin A D006801:Humans D007328:Insulin D008297:Male D008875:Middle Aged D008517:Phytotherapy D010865:Pilot Projects D018515:Plant Leaves D027842:Syzygium
myrtaceae herbal medicine hypoglycemic agents phytotherapeutics