Triglyceride-containing lipoprotein sub-fractions and risk of coronary heart disease and stroke: A prospective analysis in 11,560 adults.
AIMS
Elevated low-density lipoprotein cholesterol (LDL-C) is a risk factor for cardiovascular disease; however, there is uncertainty about the role of total triglycerides and the individual triglyceride-containing lipoprotein sub-fractions. We measured 14 triglyceride-containing lipoprotein sub-fractions using nuclear magnetic resonance and examined associations with coronary heart disease and stroke.


METHODS
Triglyceride-containing sub-fraction measures were available in 11,560 participants from the three UK cohorts free of coronary heart disease and stroke at baseline. Multivariable logistic regression was used to estimate the association of each sub-fraction with coronary heart disease and stroke expressed as the odds ratio per standard deviation increment in the corresponding measure.


RESULTS
The 14 triglyceride-containing sub-fractions were positively correlated with one another and with total triglycerides, and inversely correlated with high-density lipoprotein cholesterol (HDL-C). Thirteen sub-fractions were positively associated with coronary heart disease (odds ratio in the range 1.12 to 1.22), with the effect estimates for coronary heart disease being comparable in subgroup analysis of participants with and without type 2 diabetes, and were attenuated after adjustment for HDL-C and LDL-C. There was no evidence for a clear association of any triglyceride lipoprotein sub-fraction with stroke.


CONCLUSIONS
Triglyceride sub-fractions are associated with increased risk of coronary heart disease but not stroke, with attenuation of effects on adjustment for HDL-C and LDL-C.
['Joshi|Roshni|R|', 'Wannamethee|S Goya|SG|', 'Engmann|Jorgen|J|', 'Gaunt|Tom|T|', 'Lawlor|Deborah A|DA|', 'Price|Jackie|J|', 'Papacosta|Olia|O|', 'Shah|Tina|T|', 'Tillin|Therese|T|', 'Chaturvedi|Nishi|N|', 'Kivimaki|Mika|M|', 'Kuh|Diana|D|', 'Kumari|Meena|M|', 'Hughes|Alun D|AD|', 'Casas|Juan P|JP|', 'Humphries|Steve|S|', 'Hingorani|Aroon D|AD|', 'Schmidt|A Floriaan|AF|']
D000368:Aged D003327:Coronary Disease D005260:Female D005500:Follow-Up Studies D005544:Forecasting D014943:Global Health D006801:Humans D015994:Incidence D008074:Lipoproteins D009682:Magnetic Resonance Spectroscopy D008297:Male D008875:Middle Aged D011446:Prospective Studies D012307:Risk Factors D020521:Stroke D014280:Triglycerides
lipoproteins coronary heart disease stroke triglycerides Epidemiology metabolomics