The Bariatric Surgery Is Associated with a Lower Incidence of Malignancy: Real World Data from Taiwan.
PURPOSE
This study assessed the benefits and efficacy of bariatric surgery (BS) in reducing the risk of cancer in Asians with morbid obesity.


METHODS
Records for patients aged between 18 and 55 years whose diagnoses corresponded with the ICD-9 codes for obesity and BS were extracted from the National Health Insurance Research Database (NHIRD) in Taiwan between 2000 and 2015. The patients who underwent BS (BS group), those who did not undergo BS (NS group), and the general population (GP group) were propensity score matched. The outcome was newly diagnosed malignancy. Data were extracted from the Registry for Catastrophic Illness Patient Database (RCIPD) of the NHIRD.


RESULTS
The BS group developed significantly less malignancy (1.18%) than the GP group (1.46%, p = 0.0364). There was no statistically significant difference in malignancy risk between the BS and GP groups (aHR =1.00, p = 0.9997). The NS group developed significantly higher malignancy (2.48%) than the GP group (1.97%, p < 0.0001). There was a significantly higher malignancy risk in the NS group (aHR =1.22, p < 0.0001) than in the GP group. In the subgroup analysis, the malignancy risks of the NS group were significantly higher in the subgroup of men aged between 18 and 35 years (aHR =1.37, p = 0.003) and women aged between 18 and 35 years (aHR = 1.62, p < 0.0001), and 35-55 years (aHR = 1.27, p < 0.0001). All the subgroup analyses between the BS and GP groups demonstrated no significant differences.


CONCLUSIONS
Our study demonstrated that BS reduced the risk of malignancy in patients with morbid obesity, particularly in women and young men.
['Kao|Yi-Kai|YK|', 'Lin|Hung-Yu|HY|', 'Chen|Chih-I|CI|', 'Su|Yu-Chieh|YC|', 'Chen|Jian-Han|JH|0000-0001-7360-2238']
D000293:Adolescent D000328:Adult D050110:Bariatric Surgery D005260:Female D006801:Humans D015994:Incidence D008297:Male D008875:Middle Aged D009369:Neoplasms D009767:Obesity, Morbid D013624:Taiwan D055815:Young Adult
Bariatric surgery Real world data Cancer Obesity