Long Noncoding RNA-Sox2OT Knockdown Alleviates Diabetes Mellitus-Induced Retinal Ganglion Cell (RGC) injury.
Retinal ganglion cell (RGC) injury is one of the important pathological features of diabetes-induced retinal neurodegeneration. Increasing attention has been paid to find strategies for protecting against RGC injury. Long noncoding RNAs (lncRNAs) have emerged as the key regulators of many cell functions. Here, we show that Sox2OT expression is significantly down-regulated in the retinas of STZ-induced diabetic mice and in the RGCs upon high glucose or oxidative stress. SOX2OT knockdown protects RGCs against high glucose-induced injury in vitro. Moreover, Sox2OT knockdown plays a neuroprotective role in diabetes-related retinal neurodegeneration in vivo. Sox2OT knockdown could regulate oxidative stress response in RGCs and diabetic mouse retinas. Sox2OT knockdown plays an anti-oxidative role via regulating NRF2/HO-1 signaling activity. Taken together, Sox2OT knockdown may be a therapeutic strategy for the prevention and treatment of diabetes-induced retinal neurodegeneration.
['Li|Chao-Peng|CP|', 'Wang|Shu-Hong|SH|', 'Wang|Wen-Qi|WQ|', 'Song|Shu-Guang|SG|', 'Liu|Xiu-Ming|XM|']
D000818:Animals D002470:Cell Survival D003921:Diabetes Mellitus, Experimental D003930:Diabetic Retinopathy D055785:Gene Knockdown Techniques D005947:Glucose D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D062085:RNA, Long Noncoding D012165:Retinal Ganglion Cells
Retinal ganglion cell (RGC) Long noncoding RNA NRF2/HO-1 signaling Diabetic retinopathy