Penipyrols C-G and methyl-penipyrol A, α-pyrone polyketides from the mangrove derived fungus Penicillium sp. HDN-11-131.
Six new α-pyrone polyketides, penipyrols C-G (1-5) and methyl-penipyrol A (6), together with one biogenetically related known compound, penipyrol A (7), were isolated from the extract of fungus Penicillium sp. HDN-11-131. Their structures including the absolute configurations were established by extensive spectroscopic analysis, Mosher's method, and ECD calculations as well as biogenic considerations. Compounds 1-4 possess a rare skeleton featuring γ-butyrolactone linked to α-pyrone ring through double bond. Compound 1 can induce pancreatic β-cell regeneration in zebrafish at 10 μM, which demonstrated promising anti-diabetes potential.
['Wang|Lu|L|', 'Shi|Yeqin|Y|', 'Che|Qian|Q|', 'Zhu|Tianjiao|T|', 'Zhang|Guojian|G|', 'Zhang|Xiaokun|X|', 'Li|Mingyu|M|', 'Li|Dehai|D|']
D000818:Animals D004305:Dose-Response Relationship, Drug D007004:Hypoglycemic Agents D050417:Insulin-Secreting Cells D015394:Molecular Structure D010407:Penicillium D061065:Polyketides D011753:Pyrones D012038:Regeneration D013329:Structure-Activity Relationship D015027:Zebrafish
α-Pyrone Polyketides γ-Butyrolactone β-cell regeneration Zebrafish Diabetes