Utility of rapid on-site cytologic evaluation during endobronchial ultrasound with a guide sheath for peripheral pulmonary lesions.
Objective
The utility of rapid on-site evaluation during endobronchial ultrasound with a guide sheath for peripheral pulmonary lesions is unclear. The aim of this study was to evaluate the role of rapid on-site evaluation during endobronchial ultrasound with a guide sheath for peripheral pulmonary lesions.


Methods
Consecutive patients who underwent endobronchial ultrasound with a guide sheath for the diagnosis of peripheral pulmonary lesions at our hospital between September 2012 and July 2014 were included in this retrospective study. Cytology slides were air-dried, and modified Giemsa (Diff-Quik) staining was used for rapid on-site evaluation. Additional smears were prepared for Papanicolaou staining and tissue samples were placed in formalin for histologic evaluation. The results of rapid on-site evaluation were compared with the final diagnoses of endobronchial ultrasound with a guide sheath.


Results
A total of 718 cases were included in the study population. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of rapid on-site evaluation during endobronchial ultrasound with a guide sheath for peripheral pulmonary lesions was 88.6%, 65.9%, 81.2%, 77.7% and 80.1%, respectively. There were no procedure-related deaths.


Conclusions
Rapid on-site evaluation during endobronchial ultrasound with a guide sheath had high sensitivity for peripheral pulmonary lesions. When carrying out rapid on-site evaluation of transbronchial biopsy samples from peripheral pulmonary lesions, careful interpretation and clinical correlation are necessary.
['Izumo|Takehiro|T|', 'Matsumoto|Yuji|Y|', 'Sasada|Shinji|S|', 'Chavez|Christine|C|', 'Nakai|Toshiyuki|T|', 'Tsuchida|Takaaki|T|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D001999:Bronchoscopy D005260:Female D006801:Humans D008168:Lung D008175:Lung Neoplasms D008297:Male D008875:Middle Aged D012189:Retrospective Studies D014463:Ultrasonography
rapid on-site evaluation EBUS-GS bronchoscopy ground glass opacity radial EBUS