Anti-hyperglycaemic effects of dioxidovanadium complex cis-[VO2(obz)py] avert kidney dysfunction in streptozotocin-induced diabetic male Sprague-Dawley rats.
Despite the success of antidiabetic drugs in alleviation of hyperglycaemia, diabetic complications, including renal dysfunction, continue to be a burden. This raises the need to seek alternative therapies that will alleviate these complications. Accordingly, the aim of this study was to investigate the effects of dioxidovanadium(V) complex cis-[VO2(obz)py] on renal function in diabetic rats. Streptozotocin-induced diabetic rats were treated with cis-[VO2(obz)py] (40 mg·kg-1) twice every third day for five weeks. Diabetic untreated and insulin-treated rats served as the diabetic control and positive control, respectively. Blood glucose concentrations, water intake, urinary output, and mean arterial pressure (MAP) were monitored weekly for five weeks. Rats were then euthanized, and blood and kidney tissues were collected for biochemical analysis. Significant decreases in blood glucose concentrations, MAP, glomerular filtration rate (GFR), and SGLT2 expression, as well as plasma angiotensin and aldosterone concentrations, were observed in the treated groups compared with the diabetic control. The complex also increased urinary glucose concentrations, antioxidant enzymes GPx and SOD concentrations, and decreased MDA concentrations and kidney injury molecule (KIM-1) concentrations. These findings suggest that the anti-hyperglycaemic effects of this vanadium complex may ameliorate kidney dysfunction in diabetes.
['Mbatha|Bonisiwe|B|', 'Khathi|Andile|A|', 'Sibiya|Ntethelelo|N|', 'Booysen|Irvin|I|', 'Mangundu|Patrick|P|', 'Ngubane|Phikelelani|P|']
D000818:Animals D056831:Coordination Complexes D003921:Diabetes Mellitus, Experimental D007004:Hypoglycemic Agents D007668:Kidney D008297:Male D051381:Rats D017207:Rats, Sprague-Dawley D014639:Vanadium
kidney dysfunction hyperglycaemia SGLT2 kidney injury molecule vanadium dysfonctionnement rénal fibrose fibrosis hyperglycémie molécule de lésions rénales oxidative stress stress oxydatif