Polymorphisms of TLR2, TLR4 and TOLLIP and tuberculosis in two independent studies.
Genetic polymorphisms for tuberculosis (TB) susceptibility have been researched by some studies, but few have studied multiple innate immunity genes associated with TB. Evidence suggests that the toll-like receptor 2, 4 (TLR2, TLR4) and toll interacting protein (TOLLIP) may be associated with TB susceptibility. In this self-validated study, we explored the association between common single nucleotide polymorphisms (SNPs) of TLR2, TLR4 and TOLLIP in the Chinese Han and Tibetan populations. A SNPscan™ method was used to genotype SNPs in the three genes. Multiple logistic regression adjusted by sex and age was used to detect the association between SNPs and TB. In TLR2, rs1898830 was associated with decreased risk against TB in the Chinese Han population, which was validated in the Tibetan population. In TLR4, rs11536889 was a protective factor for TB in the Tibetan population, but not in the Han population. Additionally, in the Tibetan population, we also found that the frequency of genotypes of TOLLIP rs11536889 differs significantly between TB patients and controls. We found rs1898830 in TLR2 was associated with TB susceptibility in both Chinese Han and Tibetan populations while rs11536889 in TLR4 and rs3750920 in TOLLIP were protective factors against TB in the Tibetan population.
['Wu|Shouquan|S|', 'Liu|Xiangmin|X|', 'Chen|Ling|L|', 'Wang|Yu|Y|', 'Zhang|Miaomiao|M|', 'Wang|Minggui|M|', 'He|Jian-Qing|JQ|']
D000328:Adult D044466:Asians D016022:Case-Control Studies D002681:China D005260:Female D056726:Genetic Association Studies D020022:Genetic Predisposition to Disease D006801:Humans D047908:Intracellular Signaling Peptides and Proteins D008297:Male D008875:Middle Aged D010641:Phenotype D020641:Polymorphism, Single Nucleotide D065840:Protective Factors D018570:Risk Assessment D012307:Risk Factors D051195:Toll-Like Receptor 2 D051197:Toll-Like Receptor 4 D014376:Tuberculosis D055815:Young Adult
tuberculosis susceptibility toll-like receptor 2 4 toll interacting protein