In vivo Characterization of Amorphous Silicon Carbide As a Biomaterial for Chronic Neural Interfaces.
Implantable microelectrode arrays (MEAs) offer clinical promise for prosthetic devices by enabling restoration of communication and control of artificial limbs. While proof-of-concept recordings from MEAs have been promising, work in animal models demonstrates that the obtained signals degrade over time. Both material robustness and tissue response are acknowledged to have a role in device lifetime. Amorphous Silicon carbide (a-SiC), a robust material that is corrosion resistant, has emerged as an alternative encapsulation layer for implantable devices. We systematically examined the impact of a-SiC coating on Si probes by immunohistochemical characterization of key markers implicated in tissue-device response. After implantation, we performed device capture immunohistochemical labeling of neurons, astrocytes, and activated microglia/macrophages after 4 and 8 weeks of implantation. Neuron loss and microglia activation were similar between Si and a-SiC coated probes, while tissue implanted with a-SiC displayed a reduction in astrocytes adjacent to the probe. These results suggest that a-SiC has a similar biocompatibility profile as Si, and may be suitable for implantable MEA applications as a hermetic coating to prevent material degradation.
['Knaack|Gretchen L|GL|', 'McHail|Daniel G|DG|', 'Borda|German|G|', 'Koo|Beomseo|B|', 'Peixoto|Nathalia|N|', 'Cogan|Stuart F|SF|', 'Dumas|Theodore C|TC|', 'Pancrazio|Joseph J|JJ|']
amorphous silicon carbide foreign body response in vivo models neural electrode neuroinflammatory response neuroprosthetic device