Acute Necrotizing Pancreatitis Following Olanzapine Treatment and 759C/T Polymorphism of HTR2C Gene: A Case Report.
Acute pancreatitis can be attributed to numerous potential causes, such as alcohol abuse, chololithiasis, infection, lesions, tumors, hypercalcemia, hyperlipidemia, and medications. Among psychotropic medications, the use of some atypical antipsychotics, such as clozapine, olanzapine, quetiapine and risperidone, has been implicated in the development of acute pancreatitis, although the underlying mechanism has not been clarified. We describe the case of a young man with no other major medical problems, alcohol abuse or predisposing factors, who developed acute necrotizing pancreatitis following olanzapine administration, possibly through severe elevation of serum triglycerides. A pharmacogenomic analysis revealed the presence of the 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled (HTR2C) -759C genotype which is related to increased risk for metabolic syndrome.
['Rizos|Emmanouil|E|', 'Tournikioti|Kalliopi|K|', 'Alevyzakis|Evangelos|E|', 'Peppa|Melpomeni|M|', 'Papazaxos|Konstantinos|K|', 'Zorbas|Georgios|G|', 'Michopoulos|Ioannis|I|', 'Liappas|Ioannis|I|', 'Papageorgiou|Charalampos|C|', 'Douzenis|Athanasios|A|']
D000483:Alleles D014150:Antipsychotic Agents D001569:Benzodiazepines D057915:Drug Substitution D006239:Haplotypes D006801:Humans D008297:Male D000077152:Olanzapine D019283:Pancreatitis, Acute Necrotizing D020641:Polymorphism, Single Nucleotide D044405:Receptor, Serotonin, 5-HT2C D012559:Schizophrenia D016896:Treatment Outcome D055815:Young Adult
olanzapine Acute pancreatitis -759C/T HTR2C genetic polymorphism