Deciphering Heteroresistance to Colistin in a Klebsiella pneumoniae Isolate from Marseille, France.
Here, we report the description of a colistin-heteroresistant Klebsiella pneumoniae isolate fortuitously isolated from the stool sample of a patient with suspicion of tuberculosis in a public hospital of Marseille, France. In the colistin-resistant subpopulation, a mutation in the mgrB gene leading to a premature stop codon was found, and the hypermucoviscous phenotype was lost. Susceptibility to other antibiotics remained unchanged. To our knowledge, this is the first identification of such a colistin-heteroresistant Klebsiella pneumoniae isolate in France.
['Bardet|Lucie|L|', 'Baron|Sophie|S|', 'Leangapichart|Thongpan|T|', 'Okdah|Liliane|L|', 'Diene|Seydina M|SM|', 'Rolain|Jean-Marc|JM|']
D000900:Anti-Bacterial Agents D001426:Bacterial Proteins D003091:Colistin D024881:Drug Resistance, Bacterial D005602:France D007711:Klebsiella pneumoniae D008826:Microbial Sensitivity Tests
heteroresistance colistin Klebsiella pneumoniae mgrB