Antiviral effects of selected nucleoside analogues against human parechoviruses A1 and A3.
Parechoviruses A (HPeV, Picornaviridae) are neglected human pathogens that cause sepsis-like illness and severe neurological complications in infants. There are no antivirals available for the treatment of HPeV infections. We here report on cell-based assays that allow for medium-throughput antiviral screening of compound libraries against HPeV. The nucleoside viral polymerase inhibitor 2'-C-methylcytidine was identified as being an in vitro replication inhibitor of HPeV1 and HPeV3 that can serve as a reference molecule for further antiviral studies.
['Lanko|Kristina|K|', 'Ma|Yipeng|Y|', 'Delang|Leen|L|', 'Mirabelli|Carmen|C|', 'Neyts|Johan|J|']
D000072283:A549 Cells D000818:Animals D000998:Antiviral Agents D002522:Chlorocebus aethiops D006367:HeLa Cells D057166:High-Throughput Screening Assays D006801:Humans D051379:Mice D009705:Nucleosides D030061:Parechovirus D014709:Vero Cells D014779:Virus Replication
Antivirals Human parechovirus Picornaviruses