Genetic Variants Associated with Cancer Pain and Response to Opioid Analgesics: Implications for Precision Pain Management.
OBJECTIVE
To review the current knowledge on the association of genetic variants with cancer pain.


DATA SOURCES
Data-based publications and review articles retrieved from PubMed, CINAHL, and Web of Science, as well as an additional search in Google Scholar.


CONCLUSION
Genetic variability can influence differential pain perception and response to opioids in cancer patients, which will have implications in the optimal personalized treatment of cancer pain. More studies are warranted to replicate findings.


IMPLICATIONS FOR NURSING PRACTICE
Nurses are poised to educate patients on biomarker testing and interpretation and to use precision pain management strategies based on this information.
['Yang|Gee Su|GS|', 'Barnes|Natalie M|NM|', 'Lyon|Debra E|DE|', 'Dorsey|Susan G|SG|']
D000701:Analgesics, Opioid D000072716:Cancer Pain D014644:Genetic Variation D006801:Humans D009369:Neoplasms D059408:Pain Management D057285:Precision Medicine
Genetic variant Cancer Pain Biomarker Genetic polymorphism Precision medicine