Serum sickness-like reactions in Iranian children: a registry-based study in a referral center.
INTRODUCTION AND OBJECTIVES
Considering that no studies have been done on a comprehensive review of Serum sickness-like reactions patients (SSLRs) at a referral center in Iran so far, this study aimed to determine the clinical and laboratory characteristics of children with SSRL in Tehran Children's Medical Center.


PATIENTS
The present study was a registry-based study in which the data of 94 SSLRs patients registered in a two-year period were investigated. Confirmation of fever, rash, urticaria, arthralgia / arthritis and history of antibiotic consumption up to three weeks before were the criteria for the diagnosis.


RESULTS
Fifty-one (54 %) patients were male with mean age of 56 ± 30 months and there was no significant difference in the age of the two genders. The mean onset of symptoms before hospitalization were 3.8 ± 2.7 days (1-14 days); this mean was significantly higher in males than in females (4.6 ± 2.9 versus 2.9 ± 1.7 days, P-value = 0.003). Among antibiotics, Co-amoxiclav and Cefixime antibiotics had the most frequency by 31 % and 33 %, respectively as the most important incidence factor of SSLRs. The mean duration of consumption of culprit medications in the incidence of SSLRs was 5.6 ± 2.9 days with a range of 1-15 days.


CONCLUSIONS
This study showed that among the antibiotics, Co-amoxiclav and Cefixime are more prevalent and a review of prescribing these two antibiotics for the treatment of the children's infections is essential if this finding is confirmed by other Iranian scholars.
['Mohsenzadeh|Azam|A|', 'Movahedi|Masoud|M|', 'Saatchi|Mohammad|M|', 'Parvaneh|Nima|N|', 'Shariat|Mansoureh|M|', 'Aghamohammadi|Asghar|A|', 'Gharagozlou|Mohammad|M|']
D019980:Amoxicillin-Potassium Clavulanate Combination D000900:Anti-Bacterial Agents D001424:Bacterial Infections D020682:Cefixime D002648:Child D002675:Child, Preschool D005260:Female D006801:Humans D015994:Incidence D007492:Iran D008297:Male D015995:Prevalence D012042:Registries D012713:Serum Sickness D012737:Sex Factors
serum sickness-like reactions Iranian children Antibiotics