Celecoxib, a cyclooxygenase-2 inhibitor, offers chemoprevention against reproductive and neurobehavioural abnormalities induced by atrazine in male Wistar rats.
The cyclooxygenase-2/prostanoid pathway (COX-2) serves as a potential therapeutic target in various pathological conditions. Thus, the modulatory effect of celecoxib (CXB), a COX-2 inhibitor, in atrazine-induced toxicity was investigated. Five groups (n = 6 rats per group) of adult male Wistar rats received corn oil (2 ml/kg), atrazine (ATZ, 300 mg/kg) and CXB (5.7 mg/kg) respectively and their combinations via the oral route. Results obtained showed reduced (p < 0.05) sperm motility (25.8%) and counts (27.6%), testosterone (29.9%), luteinizing (33%) and follicle stimulating hormones (78.7%) plus elevated total cholesterol (112.3%), triglyceride (115.7%), malondialdehyde levels respectively in ATZ-treated rats. Similarly, ATZ administration causes reduced locomotion (33.6%), spontaneous motor activity (46.6%) and catalepsy effects (157.3%) respectively. However, CXB divided doses moderately reverse reproductive abnormalities, modulate neurobehavioural deficits and slightly preserved COX-2 elevation following ATZ intoxication. Furthermore, histopathology of testis shows improvement in treated rats. Overall, our data suggest chemopreventive actions via pharmacological inhibition of COX-2 activity during ATZ toxicity.
['Kale|O E|OE|', 'Oyesola|T O|TO|', 'Raji|F S|FS|']
D000818:Animals D001280:Atrazine D001522:Behavior, Animal D002375:Catalepsy D000068579:Celecoxib D018890:Chemoprevention D051546:Cyclooxygenase 2 D052246:Cyclooxygenase 2 Inhibitors D005640:Follicle Stimulating Hormone D006540:Herbicides D050356:Lipid Metabolism D008124:Locomotion D007986:Luteinizing Hormone D008297:Male D018782:Maze Learning D009422:Nervous System Diseases D017208:Rats, Wistar D012098:Reproduction D013076:Sperm Count D013081:Sperm Motility D013737:Testis D013739:Testosterone
Celecoxib Cyclooxygenase-2 Atrazine Neurobehavioural deficit Male reproduction Oxidative stress