Cytomegalovirus reactivation in patients with multiple myeloma.
The introduction of novel antimyeloma agents has improved the outcome of multiple myeloma (MM) dramatically. However, it has also led to an increasing incidence of Herpesviridae family virus infections, including a high incidence of post-transplant cytomegalovirus (CMV) reactivation after treatment with novel agents. We herein retrospectively assessed the CMV reactivation in all 120 newly diagnosed patients with MM consecutively seen and treated at our hospital. CMV antigenemia tests were ordered in 58 patients depending on the clinical context, and the incidence of CMV reactivation and proven/suspected CMV disease requiring antiviral therapy was 20% (24 of 120) and 11% (13 of 120) respectively, including those without stem cell transplantation (SCT). The clinical and laboratory characteristics of these patients were compared with those in 34 CMV antigenemia-negative (CMV-negative) patients. Patients with extramedullary disease or a low absolute lymphocyte count (ALC) had a higher risk of developing CMV reactivation. In addition, the median duration from the time of MM diagnosis to CMV reactivation was 5.0 months. These results suggest that, regardless of whether or not undergoing SCT, elderly patients with MM receiving novel agents should be monitored for CMV reactivation to allow for the timely diagnosis and treatment, especially for those with extramedullary disease.
['Hasegawa|Tetsuo|T|', 'Aisa|Yoshinobu|Y|', 'Shimazaki|Kengo|K|', 'Ito|Chisako|C|', 'Nakazato|Tomonori|T|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D000956:Antigens, Viral D003587:Cytomegalovirus D003586:Cytomegalovirus Infections D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D009101:Multiple Myeloma D012189:Retrospective Studies D014775:Virus Activation
cytomegalovirus reactivation multiple myeloma