Spectroscopic studies on the antioxidant activity of ellagic acid.
Ellagic acid (EA, C14H6O8) is a natural dietary polyphenol whose benefits in a variety of diseases shown in epidemiological and experimental studies involve anti-inflammation, anti-proliferation, anti-angiogenesis, anticarcinogenesis and anti-oxidation properties. In vitro radical scavenging and antioxidant capacity of EA were clarified using different analytical methodologies such as total antioxidant activity determination by ferric thiocyanate, hydrogen peroxide scavenging, 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH) scavenging, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging activity and superoxide anion radical scavenging, ferrous ions (Fe2+) chelating activity and ferric ions (Fe3+) reducing ability. EA inhibited 71.2% lipid peroxidation of a linoleic acid emulsion at 45 μg/mL concentration. On the other hand, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), α-tocopherol and ascorbic acid displayed 69.8%, 66.8%, 64.5% and 59.7% inhibition on the peroxidation of linoleic acid emulsion at the same concentration, respectively. In addition, EA had an effective DPPH• scavenging, ABTS+ scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, ferric ions (Fe3+) reducing power and ferrous ions (Fe2+) chelating activities. Also, those various antioxidant activities were compared to BHA, BHT, α-tocopherol and ascorbic acid as references antioxidant compounds. These results suggested that EA can be used in the pharmacological, food industry and medicine because of these properties.
['Kilic|Ismail|I|', 'Yeşiloğlu|Yeşim|Y|', 'Bayrak|Yüksel|Y|']
D000975:Antioxidants D001205:Ascorbic Acid D001713:Biphenyl Compounds D002083:Butylated Hydroxyanisole D002084:Butylated Hydroxytoluene D002614:Chelating Agents D004610:Ellagic Acid D004655:Emulsions D016166:Free Radical Scavengers D005609:Free Radicals D006861:Hydrogen Peroxide D007501:Iron D019787:Linoleic Acid D008055:Lipids D010100:Oxygen D010851:Picrates D013053:Spectrophotometry D013481:Superoxides D013861:Thiocyanates D013997:Time Factors D024502:alpha-Tocopherol
Antioxidant activity Ellagic acid Free radicals Reducing power Metal chelating