Urinalysis of MMX-mesalazine as a tool to monitor 5-ASA adherence in daily IBD practice.
Adherence is pivotal but challenging in ulcerative colitis (UC) treatment. Many methods to assess adherence are subjective or have limitations. (Nac-)5-aminosalicylic acid (5-ASA) urinalysis by high-performance liquid chromatography (HPLC) seems feasible and reproducible in healthy volunteers. We performed a prospective study in adult quiescent UC patients to evaluate the feasibility of spot (Nac-)5-ASA urinalysis by HPLC to assess adherence in daily inflammatory bowel disease (IBD) care. Twenty-nine patients (51.7% male, mean age 52 ± 11 years) were included (median FU 9 months) and weekly spot urine samples were collected. We found large variation in spot (Nac-)5-ASA urinary excretion that was unrelated to brand, dosing schedule or dosage of 5-ASA. In conclusion, spot (Nac-)5-ASA urinalysis is not applicable to assess 5-ASA adherence in daily IBD care.
['Römkens|Tessa E H|TEH|0000-0002-4184-9823', 'Te Morsche|Rene|R|', 'Peters|Wilbert|W|', 'Burger|David M|DM|0000-0001-7279-2818', 'Hoentjen|Frank|F|', 'Drenth|Joost P H|JPH|']
D000328:Adult D000368:Aged D000894:Anti-Inflammatory Agents, Non-Steroidal D002851:Chromatography, High Pressure Liquid D003093:Colitis, Ulcerative D005260:Female D005500:Follow-Up Studies D006801:Humans D008297:Male D055118:Medication Adherence D019804:Mesalamine D008875:Middle Aged D011446:Prospective Studies D016482:Urinalysis D055815:Young Adult
MMX-mesalazine adherence HPLC inflammatory bowel disease compliance