Interleukin-6 and Interleukin-10 in mood disorders: A population-based study.
OBJECTIVE
The aim of this study was to assess if cytokines levels (IL-6 and IL-10) are related to major depressive disorder (MDD) and bipolar disorder (BD), in a population-based study.


METHODS
This was a cross-sectional study population-based, involving 1037 people aged 18-35. MDD, BD, anxiety and suicide risk were assessed using the Mini International Neuropsychiatric Interview. Serum IL-6 and IL-10 were measured by ELISA using a commercial kit.


RESULTS
The total sample comprised 1034 young adults, being 14.4% with MDD and 13.7% with BD. MDD and BD groups showed significantly higher serum IL-6 levels (p ≤ 0.001) and IL-10 levels (p ≤ 0.001) when compared to healthy control group. No correlation was found between serum IL-6 and IL-10 levels in health control group (p = 0.830; r = -0.008), non-suicide risk (p = 0.337; r = 0.032) and non-anxiety disorder (p = 0.375; r = 0.031). Covariance analysis showed that mood disorders alone, increase both interleukin levels (IL-6, p = 0.019; and IL-10, p = 0.026), whilst the interaction of mood disorders and suicide risk or anxiety disorders did not.


CONCLUSION
Our results suggest that inflammatory dysregulation may be involved in the physiopathology of mood disorders and serum IL-6 and IL-10 levels are putative biomarkers for these disorders.
['Wiener|Carolina David|CD|', 'Moreira|Fernanda Pedrotti|FP|', 'Portela|Luis Valmor|LV|', 'Strogulski|Nathan R|NR|', 'Lara|Diogo R|DR|', 'da Silva|Ricardo Azevedo|RA|', 'Souza|Luciano Dias de Mattos|LDM|', 'Jansen|Karen|K|', 'Oses|Jean Pierre|JP|']
D000293:Adolescent D000328:Adult D015415:Biomarkers D001714:Bipolar Disorder D003430:Cross-Sectional Studies D003865:Depressive Disorder, Major D005260:Female D006801:Humans D016753:Interleukin-10 D015850:Interleukin-6 D008297:Male D019964:Mood Disorders D011569:Psychiatric Status Rating Scales D055815:Young Adult
Mood disorders IL-6 IL-10 MDD BD