Overexpression of CHI3L1 is associated with chemoresistance and poor outcome of epithelial ovarian carcinoma.
We propose CHI3L1 as a prognostic biomarker for patients with epithelial ovarian carcinoma (EOC) and also suggest possible biological functions of CHI3L1. We measured CHI3L1 expression with quantitative real time-polymerase chain reaction (qRT-PCR) in 180 women with EOC and evaluated correlations between CHI3L1 expression, clinicopathological characteristics, and the outcomes of the patients. The expression of CHI3L1 was higher in cancerous tissues than in normal tissues. The expression of CHI3L1 was also higher in patients with a serous histological type, advanced stage, and chemoresistance. Patients with high CHI3L1 expression had a shorter progression-free survival (p < 0.001)and overall survival (p < 0.001). Patients with high CHI3L1 expression also had a high risk of recurrence (p < 0.001)and death (p < 0.001). In vitro studies showed that CHI3L1 up-regulated the expression of anti-apoptotic Mcl-1 protein and hampered paclitaxel-induced apoptosis of ovarian cancer cells. These results suggest that CHI3L1 shows potential as a prognostic biomarker for EOC. CHI3L1 may promote chemoresistance via inhibition of drug-induced apoptosis by up-regulating Mcl-1.
['Chiang|Ying-Cheng|YC|', 'Lin|Han-Wei|HW|', 'Chang|Chi-Fang|CF|', 'Chang|Ming-Cheng|MC|', 'Fu|Chi-Feng|CF|', 'Chen|Tsung-Ching|TC|', 'Hsieh|Shu-Feng|SF|', 'Chen|Chi-An|CA|', 'Cheng|Wen-Fang|WF|']
D054392:Adipokines D000328:Adult D000368:Aged D000704:Analysis of Variance D017209:Apoptosis D014408:Biomarkers, Tumor D015153:Blotting, Western D000077216:Carcinoma, Ovarian Epithelial D045744:Cell Line, Tumor D000071451:Chitinase-3-Like Protein 1 D018572:Disease-Free Survival D019008:Drug Resistance, Neoplasm D005260:Female D015972:Gene Expression Regulation, Neoplastic D006801:Humans D037102:Lectins D008875:Middle Aged D064549:Myeloid Cell Leukemia Sequence 1 Protein D009375:Neoplasms, Glandular and Epithelial D017063:Outcome Assessment, Health Care D010051:Ovarian Neoplasms D017239:Paclitaxel D011379:Prognosis D016016:Proportional Hazards Models D034622:RNA Interference D020133:Reverse Transcriptase Polymerase Chain Reaction
CHI3L1 chemoresistance epithelial ovarian carcinoma apoptosis