Evidence for the existence of nociceptors in rat thoracolumbar fascia.
Recently, the existence of nociceptive fibers in fascia tissue has attracted much interest. Fascia can be a source of pain in several disorders such as fasciitis and non-specific low back pain. However, little is known about the properties of fascia nociceptors and possible changes of the fascia innervation by nociceptors under pathological circumstances. In this histologic study, the density of presumably nociceptive fibers and free nerve endings was determined in the three layers of the rat TLF: inner layer (IL, covering the multifidus muscle), middle layer (ML) and outer layer (OL). As markers for nociceptive fibers, antibodies to the neuropeptides CGRP and SP as well as to the transient receptor potential vanilloid 1 (TRPV1) were used. As a pathological state, inflammation of the TLF was induced with injection of complete Freund's adjuvant. The density of CGRP- and SP-positive fibers was significantly increased in the inner and outer layer of the inflamed fascia. In the thick middle layer, no inflammation-induced change occurred. In additional experiments, a neurogenic inflammation was induced in the fascia by electrical stimulation of dorsal roots. In these experiments, plasma extravasation was visible in the TLF, which is clear functional evidence for the existence of fascia nociceptors. The presence of nociceptors in the TLF and the increased density of presumably nociceptive fibers under chronic painful circumstances may explain the pain from a pathologically altered fascia. The fascia nociceptors probably contribute also to the pain in non-specific low back pain.
['Mense|Siegfried|S|', 'Hoheisel|Ulrich|U|']
D000818:Animals D015740:Calcitonin Gene-Related Peptide D004195:Disease Models, Animal D005205:Fascia D005208:Fasciitis D007249:Inflammation D008297:Male D009619:Nociceptors D051381:Rats D017207:Rats, Sprague-Dawley D013373:Substance P D050916:TRPV Cation Channels
Fasciitis Non-specific low back pain Fascia nociceptors Inflammation Neurogenic inflammation