One-pot synthesis of biocompatible superparamagnetic iron oxide nanoparticles/hydrogel based on salep: characterization and drug delivery.
This work describes synthesis of biocompatible magnetic iron oxide nanoparticles/hydrogel based on salep (MION-salep hydrogel) by a facile one-pot strategy. The prepared sample was characterized by techniques like scanning electron microscopy with energy dispersive X-ray analysis (SEM-EDAX), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), and vibrating sample magnetometer (VSM). The obtained MION had an 8 nm diameter with a narrow size distribution and was superparamagnetic with large saturation magnetization at room temperature. The most attractive feature of the obtained sample was its swelling properties under external magnetic field (EMF), different temperatures, and pHs. Moreover, MION-salep hydrogel showed ability to deferasirox release at pH=7 with non-Fickian diffusion mechanism. An in vitro cytotoxicity study implied that the as-synthesized sample is nontoxic.
['Bardajee|Ghasem Rezanejade|GR|', 'Hooshyar|Zari|Z|']
D001672:Biocompatible Materials D002460:Cell Line D002470:Cell Survival D055598:Chemical Phenomena D060326:Chemistry Techniques, Synthetic D004337:Drug Carriers D004355:Drug Stability D004847:Epithelial Cells D005290:Ferric Compounds D006801:Humans D020136:Hydrogel, Polyethylene Glycol Dimethacrylate D059346:Magnets D053758:Nanoparticles D029595:Orchidaceae D013696:Temperature
Hydrogel Salep Drug delivery Magnetic iron oxide nanoparticles