Overexpressed LAPTM4B-35 is a risk factor for cancer recurrence and poor prognosis in non-small-cell lung cancer.
BACKGROUND
The expression levels and clinical significances of Lysosomal-associated protein transmembrane-4β-35 (LAPTM4B-35) protein are unknown in the non-small-cell lung cancer (NSCLC). This study aimed to explore the expression and prognostic value of LAPTM4B-35 in NSCLC patients.


METHODS
The clinicopathological and survival data of 107 NSCLC patients who received radical surgery from 2007 and 2011 were reviewed. The LAPTM4B-35 expression of the paired tumors and adjacent normal specimens were detected, and the association between LAPTM4B-35 and clinical variables was explored. Kaplan-Meier analysis and Cox regression (Proportional hazard model) were performed to investigate the prognostic significance for NSCLC.


RESULTS
LAPTM4B-35 was over expressed in NSCLC tissues. The elevated LAPTM4B-35 expression was associated with cancer recurrence (P = 0.031). The 5-year median OS and PFS were significantly worse in the LAPTM4B-35 overexpressed group. Multivariate Cox analysis showed that LAPTM4B-35 over-expression was an independent factor for OS and PFS in NSCLC(P = 0.018, P = 0.026, respectively).


CONCLUSIONS
The overexpressed LAPTM4B-35 was an independent prognostic biomarker for NSCLC, which could predict cancer recurrence and poor over survival. And that may be applied as potential target for NSCLC treatment.
['Kong|Fanming|F|', 'Gao|Fangfang|F|', 'Chen|Jun|J|', 'Sun|Yiyu|Y|', 'Zhang|Ying|Y|', 'Liu|Honggen|H|', 'Li|Xiaojiang|X|', 'Yang|PeiYing|P|', 'Zheng|Rongxiu|R|', 'Liu|Geli|G|', 'Jia|Yingjie|Y|']
D000368:Aged D014408:Biomarkers, Tumor D002289:Carcinoma, Non-Small-Cell Lung D018572:Disease-Free Survival D005260:Female D005500:Follow-Up Studies D015972:Gene Expression Regulation, Neoplastic D006801:Humans D053208:Kaplan-Meier Estimate D008175:Lung Neoplasms D008297:Male D008565:Membrane Proteins D008875:Middle Aged D009364:Neoplasm Recurrence, Local D009367:Neoplasm Staging D015513:Oncogene Proteins D011379:Prognosis D016016:Proportional Hazards Models D012307:Risk Factors
LAPTM4B-35 cancer recurrence prognosis non-small-cell lung cancer lung cancer