Loss of the tRNALys CUU encoding gene, Chr-11 tRNA-Lys-CUU, is not associated with Type 2 diabetes mellitus.
AIM
To investigate the presence/absence of the Chr-11 tRNA-Lys-CUU gene as a marker for genetic predisposition to Type 2 diabetes mellitus (T2DM).


METHODS
We enrolled 122 patients diagnosed with T2DM and 77 non-diabetic individuals. We evaluated clinical and biochemical parameters (body mass index, hypertension, cholesterol levels, glycosylated hemoglobin, triglycerides, etc.), and performed a genotypic profiling of Chr-11 tRNA-Lys-CUU by polymerase chain reaction analyses.


RESULTS
Approximately one third of the population lacked Chr-11 tRNA-Lys-CUU. We did not observe a statistically significant association between the presence/absence of Chr-11 tRNA-Lys-CUU and T2DM.


CONCLUSION
The genotypic distribution of Chr-11 tRNA-Lys-CUU in our population was consistent to that reported by others. This gene failed as a marker for T2DM predisposition.
['Yang|Pablo|P|', 'Beltramo|Dante Miguel|DM|', 'de Pouplana|Lluís Ribas|LR|', 'Soria|Néstor Walter|NW|', 'Torres|Adrian Gabriel|AG|']
D000368:Aged D015415:Biomarkers D016022:Case-Control Studies D002880:Chromosomes, Human, Pair 11 D003924:Diabetes Mellitus, Type 2 D005260:Female D017353:Gene Deletion D020022:Genetic Predisposition to Disease D006801:Humans D008297:Male D008875:Middle Aged D011379:Prognosis D012357:RNA, Transfer, Lys D013030:Spain
tRNA-Lys-CUU Type 2 diabetes mellitus T2DM genotypic profiling PCR biomarker gene translation insulin tRNA tRNA gene