Growth Factors in the Carotid Body-An Update.
The carotid body may undergo plasticity changes during development/ageing and in response to environmental (hypoxia and hyperoxia), metabolic, and inflammatory stimuli. The different cell types of the carotid body express a wide series of growth factors and corresponding receptors, which play a role in the modulation of carotid body function and plasticity. In particular, type I cells express nerve growth factor, brain-derived neurotrophic factor, neurotrophin 3, glial cell line-derived neurotrophic factor, ciliary neurotrophic factor, insulin-like-growth factor-I and -II, basic fibroblast growth factor, epidermal growth factor, transforming growth factor-α and -β, interleukin-1β and -6, tumor necrosis factor-α, vascular endothelial growth factor, and endothelin-1. Many specific growth factor receptors have been identified in type I cells, indicating autocrine/paracrine effects. Type II cells may also produce growth factors and express corresponding receptors. Future research will have to consider growth factors in further experimental models of cardiovascular, metabolic, and inflammatory diseases and in human (normal and pathologic) samples. From a methodological point of view, microarray and/or proteomic approaches would permit contemporary analyses of large groups of growth factors. The eventual identification of physical interactions between receptors of different growth factors and/or neuromodulators could also add insights regarding functional interactions between different trophic mechanisms.
['Stocco|Elena|E|', 'Barbon|Silvia|S|', 'Tortorella|Cinzia|C|', 'Macchi|Veronica|V|', 'De Caro|Raffaele|R|', 'Porzionato|Andrea|A|']
D000818:Animals D019208:Brain-Derived Neurotrophic Factor D002344:Carotid Body D020934:Ciliary Neurotrophic Factor D004815:Epidermal Growth Factor D016222:Fibroblast Growth Factor 2 D005786:Gene Expression Regulation D051100:Glial Cell Line-Derived Neurotrophic Factor D006801:Humans D018496:Hyperoxia D000860:Hypoxia D007334:Insulin-Like Growth Factor I D020932:Nerve Growth Factor D020933:Neurotrophin 3 D017978:Receptors, Growth Factor D016211:Transforming Growth Factor alpha D016212:Transforming Growth Factor beta D042461:Vascular Endothelial Growth Factor A
growth factors carotid body development hypoxia hyperoxia receptors BDNF GDNF Parkinson’s disease VEGF receptor–receptor interactions