On the Emergence of Candida auris: Climate Change, Azoles, Swamps, and Birds.
The most enigmatic aspect of the rise of Candida auris as a human pathogen is that it emerged simultaneously on three continents, with each clade being genetically distinct. Although new pathogenic fungal species are described regularly, these are mostly species associated with single cases in individuals who are immunosuppressed. In this study, we used phylogenetic analysis to compare the temperature susceptibility of C. auris with those of its close relatives and to use these results to argue that it may be the first example of a new fungal disease emerging from climate change, with the caveat that many other factors may have contributed.
['Casadevall|Arturo|A|0000-0002-9402-9167', 'Kontoyiannis|Dimitrios P|DP|0000-0002-8051-2940', 'Robert|Vincent|V|']
D000818:Animals D000935:Antifungal Agents D001393:Azoles D001717:Birds D002175:Candida D002177:Candidiasis D057231:Climate Change D021821:Communicable Diseases, Emerging D026141:Drug Resistance, Multiple, Fungal D006801:Humans D008826:Microbial Sensitivity Tests D010802:Phylogeny D013696:Temperature
Candida climate change fungus