Neurocircuitry associated with symptom dimensions at baseline and with change in borderline personality disorder.
Borderline personality disorder (BPD) is a serious illness associated with chronic suffering and self-injurious behavior. Parsing the relationships between specific symptom domains and their underlying biological mechanisms may help us further understand the neural circuits implicated in these symptoms and how they might be amenable to change with treatment. This study examines the association between symptom dimensions (Affective Disturbance, Cognitive Disturbance, Disturbed Relationships, and Impulsivity) and amygdala resting-state functional connectivity (RSFC) in a sample of adults with BPD (n = 18). We also explored the relationships between change in symptom dimensions and change in amygdala RSFC in a subset of this sample (n = 13) following 8 weeks of quetiapine or placebo. At baseline, higher impulsivity was associated with increased positive RSFC between right amygdala and left hippocampus. There were no significant differences in neural change between treatment groups. Improvement in cognitive disturbance was associated with increased positive RSFC between left amygdala and temporal fusiform and parahippocampal gyri. Improvement in disturbed relationships was associated with increased negative RSFC between right amygdala and frontal pole. These results support that specific dimensions of BPD are associated with specific neural connectivity patterns at baseline and with change, which may represent neural treatment targets.
['Westlund Schreiner|Melinda|M|', 'Klimes-Dougan|Bonnie|B|', 'Mueller|Bryon A|BA|', 'Nelson|Katharine J|KJ|', 'Lim|Kelvin O|KO|', 'Cullen|Kathryn R|KR|']
D000328:Adult D000679:Amygdala D014150:Antipsychotic Agents D001883:Borderline Personality Disorder D005260:Female D006624:Hippocampus D006801:Humans D007175:Impulsive Behavior D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D000069348:Quetiapine Fumarate D012146:Rest D055815:Young Adult
Symptom dimension Borderline personality disorder Resting-state functional connectivity Neuroimaging