Impact of anti-infective periodontal therapy on parameters of vascular health.
AIM
This study assessed the impact of anti-infective periodontal therapy on the status of vascular health.


MATERIALS AND METHODS
Periodontal and vascular health of 55 patients with severe untreated chronic periodontitis was evaluated before and 12 months after anti-infective periodontal therapy. Observed parameters were bleeding on probing (BoP), pocket probing depth (PPD), periodontal inflamed surface area index (PISA), pulse wave velocity (PWV), augmentation index (AIx), central pulse pressure (PPao) and peripheral systolic pressure (RRsys).


RESULTS
ΔPISA (baseline-12 months) correlated with ΔPWV (τ 0.21; p < .03), ΔAIx (τ 0.29; p < .002) and ΔPPao (τ 0.23; p < .02). ΔBoP% (baseline-12 months) correlated with ΔPWV (τ 0.18; p < .05) and ΔAIx (τ 0.25; p < .01), while mean ΔPPD (baseline-12 months) correlated with ΔPWV (τ 0.24; p < .01) and ΔAIx (τ 0.21; p < .03). Grouping patients evenly into three groups based on tertiles of BoP resolution after 12 months revealed a significant decrease in the observed PWV median value by -0.6 m/s (p < .04) in the best response tertile (ΔBoP ≥ 88%). In the worst response tertile (ΔBoP ≤ 66%), by contrast, significant increase in PPao (+10.5 mmHg; p < .02) and AIx (+5.5; p < .02) was observed.


CONCLUSION
Efficacious resolution of periodontal inflammation may beneficially impact on vascular health.
['Jockel-Schneider|Yvonne|Y|0000-0002-5646-3691', 'Bechtold|Markus|M|', 'Haubitz|Imme|I|', 'Störk|Stefan|S|', 'Fickl|Stefan|S|', 'Harks|Inga|I|', 'Eigenthaler|Martin|M|', 'Vollrath|Oliver|O|', 'Baulmann|Johannes|J|', 'Schlagenhauf|Ulrich|U|']
D000890:Anti-Infective Agents D001794:Blood Pressure D055113:Chronic Periodontitis D006801:Humans D008875:Middle Aged D010512:Periodontal Index D063177:Pulse Wave Analysis D059289:Vascular Stiffness
periodontal therapy periodontitis pulse wave velocity inflammation arterial stiffness central blood pressure