Magainin-modified polydopamine nanoparticles for photothermal killing of bacteria at low temperature.
Photothermal therapy (PTT) is a promising method to kill bacteria because of the broad-spectrum of antibacterial activity and the ability of spatiotemporal regulation. In the previously reported systems, light induced high temperature (˜70 °C) was essential for effectively killing of bacteria, which, however, would also damage nearby nontarget cells or tissues. Here we report photothermal nanoparticles (NPs) for more targeting and killing bacteria at a relative low temperature. Polydopamine (PDA) was chosen to prepare NPs because of its excellent capability of photothermal conversion. Magainin I (MagI) which is an antimicrobial peptide was used to modify NPs' surface because it can specifically interact with bacteria. We demonstrate that MagI-PEG@PDA NPs effectively killed E. coli at a low temperature of ˜45 °C upon near-infrared (NIR) light irradiation. In contrast, the native PDA NPs under light irradiation or the MagI-PEG@PDA NPs themselves showed no bacteria killing ability. This work highlights the importance of close interaction between the target bacteria and the photothermal materials and may promote the practical clinical applications of the PTT.
['Fan|Xiao-Li|XL|', 'Li|He-Yang|HY|', 'Ye|Wan-Ying|WY|', 'Zhao|Ming-Qi|MQ|', 'Huang|Dan-Ni|DN|', 'Fang|Yu|Y|', 'Zhou|Bin-Quan|BQ|', 'Ren|Ke-Feng|KF|', 'Ji|Jian|J|', 'Fu|Guo-Sheng|GS|']
D000818:Animals D000900:Anti-Bacterial Agents D023181:Antimicrobial Cationic Peptides D002470:Cell Survival D004926:Escherichia coli D007211:Indoles D007259:Infrared Rays D051379:Mice D008826:Microbial Sensitivity Tests D050296:Microbial Viability D041681:NIH 3T3 Cells D053758:Nanoparticles D011092:Polyethylene Glycols D011108:Polymers D013696:Temperature
Polydopamine Low temperature Photothermal therapy Magainin Antibacterial nanoparticles