Physical co-morbidity among treatment resistant vs. treatment responsive patients with major depressive disorder.
Co-morbid physical illness has been suggested to play an important role among the factors contributing to treatment resistance in patients with major depressive disorder. In the current study we compared the rate of physical co-morbidity, defined by ICD-10, among a large multicenter sample of 702 patients with major depressive disorder. A total of 356 of the participants were defined as treatment resistant depression (TRD) patients-having failed two or more adequate antidepressant trials. No significant difference was found between TRD and non-TRD participants in the prevalence of any ICD-10 category. This finding suggests that although physical conditions such as diabetes, thyroid dysfunction, hypertension, ischemic heart disease, and peptic diseases are often accompanied by co-morbid MDD, they do not necessarily have an impact on the course of MDD or the likelihood to respond to treatment. Marginally higher rates of co-morbid breast cancer, migraine and glaucoma were found among TRD participants. Possible explanations for these findings and their possible relation to TRD are discussed.
['Amital|D|D|', 'Fostick|L|L|', 'Silberman|A|A|', 'Calati|R|R|', 'Spindelegger|C|C|', 'Serretti|A|A|', 'Juven-Wetzler|A|A|', 'Souery|D|D|', 'Mendlewicz|J|J|', 'Montgomery|S|S|', 'Kasper|S|S|', 'Zohar|J|J|']
D000328:Adult D000928:Antidepressive Agents D001943:Breast Neoplasms D015897:Comorbidity D003865:Depressive Disorder, Major D039721:Diagnostic and Statistical Manual of Mental Disorders D004351:Drug Resistance D005060:Europe D005260:Female D005901:Glaucoma D006801:Humans D007557:Israel D008297:Male D008881:Migraine Disorders D015995:Prevalence D011569:Psychiatric Status Rating Scales D012189:Retrospective Studies D011795:Surveys and Questionnaires
Physical co-morbidity Treatment resistance Treatment response Depression