Upregulation of cystatin SN promotes hepatocellular carcinoma progression and predicts a poor prognosis.
Cystatin SN, a specific cysteine protease inhibitor, is thought to be involved in various malignant tumors. Therefore, we evaluated the role of cystatin SN in hepatocellular carcinoma (HCC). Notably, cystatin SN was elevated in tumorous samples and cells. Moreover, overexpression of cystatin SN was correlated with tumor diameter and TNM stage. Cox multivariate analysis displayed that cystatin SN was an independent prognosis indicator and that high cystatin SN level was associated with a dismal prognosis. Moreover, cystatin SN enhancement facilitated the proliferation, migratory, and invasive potential of Huh7 and HCCLM3 cells, whereas cystatin SN knockdown caused the opposite effect. Cystatin SN also modulated the epithelial-mesenchymal transition progression through the PI3K/AKT pathway. In vivo cystatin SN promoted HCCLM3 cell growth and metastasis in xenograft mice model. Thus, cystatin SN was involved in HCC progression and could be a latent target for HCC treatment.
['Cui|Yifeng|Y|', 'Sun|Dan|D|', 'Song|Ruipeng|R|', 'Zhang|Shugeng|S|', 'Liu|Xirui|X|', 'Wang|Yan|Y|', 'Meng|Fanzheng|F|', 'Lan|Yaliang|Y|', 'Han|Jihua|J|', 'Pan|Shangha|S|', 'Liang|Shuhang|S|', 'Zhang|Bo|B|', 'Guo|Hongrui|H|', 'Liu|Yufeng|Y|', 'Lu|Zhaoyang|Z|0000-0003-4588-2521', 'Liu|Lianxin|L|']
D000818:Animals D014408:Biomarkers, Tumor D006528:Carcinoma, Hepatocellular D045744:Cell Line, Tumor D002465:Cell Movement D049109:Cell Proliferation D005260:Female D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008113:Liver Neoplasms D008297:Male D051379:Mice D008875:Middle Aged D009374:Neoplasms, Experimental D019869:Phosphatidylinositol 3-Kinases D011379:Prognosis D051057:Proto-Oncogene Proteins c-akt D055333:Salivary Cystatins D015854:Up-Regulation
cystatin SN hepatocellular carcinoma epithelial-mesenchymal transition cell proliferation prognostic marker