Vascular effects of exercise training in CKD: current evidence and pathophysiological mechanisms.
Cardiovascular disease remains the main cause of morbidity and mortality in patients with CKD, an observation that cannot be explained by the coexistence of traditional risk factors alone. Recently, other mechanisms, such as alterations in nitric oxide bioavailability, impaired endothelial repair mechanisms, inflammation, and oxidative stress (all characteristic in CKD), have gained much attention as mediators for the increased cardiovascular risk. Regular physical training is a valuable nonpharmacological intervention for primary and secondary prevention of cardiovascular disease. Likewise, the benefits of exercise training on exercise capacity and quality of life are increasingly recognized in patients with CKD. Furthermore, exercise training could also influence potential reversible mechanisms involved in atherosclerosis and arteriosclerosis. After discussing briefly the general concepts of vascular disease in CKD, this review provides an overview of the current evidence for the effects of exercise training at both clinical and preclinical levels. It concludes with some practical considerations on exercise training in this specific patient group.
['Van Craenenbroeck|Amaryllis H|AH|', 'Van Craenenbroeck|Emeline M|EM|', 'Kouidi|Evangelia|E|', 'Vrints|Christiaan J|CJ|', 'Couttenye|Marie M|MM|', 'Conraads|Viviane M|VM|']
D000818:Animals D001158:Arteries D015897:Comorbidity D005081:Exercise Therapy D006439:Hemodynamics D006801:Humans D051436:Renal Insufficiency, Chronic D012307:Risk Factors D016896:Treatment Outcome D014652:Vascular Diseases
glomerular filtration glomerulus renal physiology