Near-infrared heat lamp therapeutic effect on paraoxonase 1 and myeloperoxidase as potential biomarkers of redox state changes induced by γ-irradiation in albino rats.
Infrared radiation has a potential therapeutic effect in some diseases. The aim of this study was to estimate the therapeutic role of near infrared heat lamp (NIRHL) on the variations of the activity of paraoxonase 1 (PON1) and myeloperoxidase (MPO), in relation to lipid disorders, associated with oxidative stress in rats gamma-irradiated. In addition, study the effect of the duration of NIRHL treatment. Animals were divided into six groups. The results revealed that irradiated rats treated with NIRHL 20 min/once/day showed positive modulation of PON1 and MPO linked to significant improvement of lipid disorders evidenced by lower triglycerides, low density lipoprotein cholesterol (LDL-C), oxidized low density lipoprotein cholesterol (oxLDL-C) and higher density lipoprotein cholesterol (HDL-C) as well as significant amelioration of redox state, manifested by markedly increase of glutathione (GSH) content, total antioxidant capacity (TAC) associated with a noticeable decrease of pro-inflammatory cytokines. (TNF-α, IL-1 beta and IL-6), nitric oxide (NO), nitric oxide synthase (NOs), malondialdehyde (MDA), compared to irradiated rats. The results showed also that the NIRHL treatment for 20 min/twice/day had negative effects on the previous parameters and on the behavior of rats such as itching, irritability, dyspnea and death in normal as well as, irradiated rats. In conclusion, the results in this study show that NIRHL therapy for a short time can effectively prevent the lipid disorders induced by radiation through the positive modulation mechanism of PON1 and MPO enzymes and improvement of oxidative stress.
['Abdel-Magied|N|N|', 'Ahmed|A G|AG|', 'Shedid|S M|SM|']
D000818:Animals D043303:Aryldialkylphosphatase D015415:Biomarkers D002118:Calcium D008076:Cholesterol, HDL D008078:Cholesterol, LDL D016207:Cytokines D005720:Gamma Rays D005978:Glutathione D007259:Infrared Rays D008297:Male D008315:Malondialdehyde D009569:Nitric Oxide D010084:Oxidation-Reduction D009195:Peroxidase D051381:Rats D017207:Rats, Sprague-Dawley D013696:Temperature D014916:Whole-Body Irradiation
Paraoxonase Myeloperoxidase Rats Infrared Radiation Lipids