Nitroglycerin-Citrate-Ethanol Catheter Lock Solution Is Highly Effective for In Vitro Eradication of Candida auris Biofilm.
Candida auris poses emerging risks for causing severe central line-associated bloodstream infections. We tested in vitro the ability of antifungal lock solutions to rapidly eradicate C. auris biofilms. Liposomal amphotericin B, amphotericin B deoxycholate, fluconazole, voriconazole, micafungin, caspofungin, and anidulafungin failed to completely eradicate all 10 tested C. auris biofilms. Conversely, nitroglycerin-citrate-ethanol (NiCE) catheter lock solution completely eradicated all replicates for all of C. auris biofilms tested.
['Vargas-Cruz|Nylev|N|', 'Reitzel|Ruth A|RA|', 'Rosenblatt|Joel|J|', 'Chaftari|Anne-Marie|AM|', 'Wilson Dib|Rita|R|', 'Hachem|Ray|R|', 'Kontoyiannis|Dimitrios P|DP|0000-0002-8051-2940', 'Raad|Issam I|II|']
D000666:Amphotericin B D000077612:Anidulafungin D000935:Antifungal Agents D018441:Biofilms D002175:Candida D000077336:Caspofungin D055499:Catheter-Related Infections D057785:Catheters D019343:Citric Acid D000431:Ethanol D015725:Fluconazole D000077551:Micafungin D005996:Nitroglycerin D019999:Pharmaceutical Solutions D065819:Voriconazole
nitroglycerin-citrate-ethanol catheter lock solution Candida auris biofilm