Platelet distribution width as the prognostic marker in coronary bifurcation treatment.
BACKGROUND
Mean platelet volume (MPV) was proved to be a reliable prognostic factor in cardiac patients. However, platelet distribution width (PDW) was disclosed to be more specific marker of platelet reactivity. The aim of study was to evaluate whether baseline PDW value can predict the outcome in patients undergoing percutaneous coronary interventions (PCI) with drug-eluting stent implantation within coronary bifurcation lesions.


MATERIALS AND METHODS
It was a two-centre observational study, which included patients who underwent PCI within bifurcation lesions between January 2014 and December 2014. Thrombocytopenia below 100 000/μL and STEMI were the exclusion criteria. Analysed data came entirely from in-hospital records and information obtained from the 12-month telephone follow-up.


RESULTS
We included 269 patients. Mean PDW value was 13·4 ± 2·5 fL, whereas median was 13 (Q1 < 11·6 fL, Q2 11·6-13 fL, Q3 13-14·8 fL and Q4 > 14·8 fL). We found strong correlation between PDW and MPV (r = 0·96, P < 0·001), but no correlation was revealed between red blood cell distribution width (RDW) and PDW (r = 0·003, P = 0·95) as well as RDW and MPV (r = 0·0018, P = 0·98). Receiver operating characteristics (ROC) curve showed that PDW for cutoff 15·8% can predict MACE rate with sensitivity of 79% and specificity of 47% (area under curve - AUC 0·654; P = 0·01). A ROC curve for PDW categorized by 1-year TLR rate was described by optimal cutoff 16·3%, with sensitivity 69% and specificity 54% (AUC 0·697; P = 0·0015).


CONCLUSIONS
PDW is an affordable and reliable predictor of 1-year MACE and TLR rate after PCI within coronary bifurcation lesions.
['Kern|Adam|A|', 'Gil|Robert J|RJ|', 'Bojko|Krystian|K|', 'Sienkiewicz|Ewa|E|', 'Januszko-Giergielewicz|Beata|B|', 'Górny|Jerzy|J|', 'Bil|Jacek|J|http://orcid.org/0000-0002-8724-5611']
D000368:Aged D001241:Aspirin D001792:Blood Platelets D000077144:Clopidogrel D003324:Coronary Artery Disease D054855:Drug-Eluting Stents D005260:Female D006801:Humans D008297:Male D063847:Mean Platelet Volume D008875:Middle Aged D009204:Myocardial Revascularization D000072658:Non-ST Elevated Myocardial Infarction D062645:Percutaneous Coronary Intervention D010975:Platelet Aggregation Inhibitors D012008:Recurrence D013988:Ticlopidine D016896:Treatment Outcome
platelets mean platelet volume red blood cell distribution width