A comprehensive analysis of the MAGE family as prognostic and diagnostic markers for hepatocellular carcinoma.
The Melanoma Antigen Gene (MAGE) family is a large, highly conserved group of proteins which was reported to participate in the progression of multiple cancers in humans. However, the function of distinct MAGE genes in hepatocellular carcinoma (HCC) is largely unclear. In this study, we comprehensively evaluated the expression, clinical significance, genetic alteration, interaction network and functional enrichment of MAGEs in HCC. Our research showed that many MAGE genes were dysregulated in HCC. Among them, MAGEA1, MAGEC2, MAGED1, MAGED2, MAGEF1 and MAGEL2 were significantly associated with clinical stage and differentiation of HCC. MAGED1, MAGED2, MAGEA6, MAGEA12, MAGEA10, MAGEB4, MAGEL2 and MAGEC3 significantly correlated with HCC prognosis. Further functional enrichment analysis suggested the dysregulated MAGEs may play important roles in signal transduction. These results indicate that multiple dysregulated MAGEs might play important roles in the development of HCC and can be exploited as useful biomarkers for diagnosis and treatment in HCC.
['Li|Rong|R|', 'Gong|Jiao|J|', 'Xiao|Cuicui|C|', 'Zhu|Shuguang|S|', 'Hu|Zhongying|Z|', 'Liang|Jinliang|J|', 'Li|Xuejiao|X|', 'Yan|Xijing|X|', 'Zhang|Xijian|X|', 'Li|Danyang|D|', 'Liu|Wei|W|', 'Chong|Yutian|Y|', 'Jie|Yusheng|Y|']
D000951:Antigens, Neoplasm D006528:Carcinoma, Hepatocellular D005260:Female D020869:Gene Expression Profiling D006801:Humans D008113:Liver Neoplasms D008297:Male D008875:Middle Aged D009363:Neoplasm Proteins D011379:Prognosis D025941:Protein Interaction Mapping
MAGE family Prognostic and diagnostic markers Hepatocellular carcinoma