The meninges enhance leukaemia survival in cerebral spinal fluid.
Central nervous system (CNS) relapse is a common cause of treatment failure in patients with acute lymphoblastic leukaemia (ALL) despite current CNS-directed therapies that are also associated with significant short- and long-term toxicities. Herein, we showed that leukaemia cells exhibit decreased proliferation, elevated reactive oxygen species (ROS) and increased cell death in cerebral spinal fluid (CSF) both in vitro and in vivo. However, interactions between leukaemia and meningeal cells mitigated these adverse effects. This work expands our understanding of the pathophysiology of CNS leukaemia and suggests novel therapeutic approaches for more effectively targeting leukaemia cells in the CNS.
['Basile|Patrick|P|', 'Jonart|Leslie M|LM|', 'Ebadi|Maryam|M|', 'Johnson|Kimberly|K|', 'Kerfeld|Morgan|M|', 'Gordon|Peter M|PM|']
D006801:Humans D008578:Meninges D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma D016019:Survival Analysis
cerebral spinal fluid central nervous system cell death acute lymphpoblastic leukaemia cell adhesion