Effect of non-surgical periodontal therapy on plasma homocysteine levels in Indian population with chronic periodontitis: a pilot study.
AIM
Homocysteine (Hcy) is implicated in the development of cardiovascular diseases (CVD). The effect of periodontal disease and periodontal therapy on plasma Hcy remains controversial. Hence, in this pilot study we assessed the effect of periodontal disease and non-surgical periodontal therapy (NSPT) on plasma Hcy in systemically healthy Indian subjects.


MATERIALS AND METHODS
Forty participants (30 to 39 years) were enrolled in the study and were divided into two groups based on gingival index, probing depth, and clinical attachment level (CAL): Healthy (control group; n = 20) and Chronic Periodontitis (test group; n = 20). Plasma samples were collected and quantified at baseline and 12 weeks after scaling and root planing (SRP) for Hcy using High Performance Liquid Chromatography with fluorescent detection (HPLC-fld).


RESULTS
Plasma Hcy levels of chronic periodontitis (17.87 ± 1.21 μmol/l) subjects was significantly higher than healthy subjects (9.09 ± 2.11 μmol/l). Post-therapy, the plasma Hcy concentration reduced significantly (11.34 ± 1.87 μmol/l) (p < 0.05).


CONCLUSION
The rise and descent of plasma Hcy levels with periodontal inflammation and therapy, respectively, indicate a direct relationship of Hcy with chronic periodontitis. NSPT may be employed as an adjunctive Hcy Lowering Therapy, contributing towards primary prevention against CVD's.
['Bhardwaj|Smiti|S|', 'Prabhuji|M L Venkatesh|ML|', 'Karthikeyan|Bangalore Vardhan|BV|']
D000328:Adult D016301:Alveolar Bone Loss D016022:Case-Control Studies D002851:Chromatography, High Pressure Liquid D055113:Chronic Periodontitis D003774:Dental Plaque Index D012534:Dental Scaling D005260:Female D005453:Fluorescence D005500:Follow-Up Studies D006710:Homocysteine D006801:Humans D008297:Male D009910:Oral Hygiene D009911:Oral Hygiene Index D017622:Periodontal Attachment Loss D057747:Periodontal Debridement D010512:Periodontal Index D010514:Periodontal Pocket D010865:Pilot Projects D016745:Root Planing
plasma homocysteine chronic periodontitis scaling root planing