High lactate dehydrogenase was associated with adverse outcomes in patients with acute ischemic stroke or transient ischemic attack.
BACKGROUND
Previous studies found that lactate dehydrogenase (LDH) levels predicted poor outcomes in hemorrhagic stroke, but the prognostic role of LDH in ischemic stroke (IS) remains unclear. The aim of this study is to investigate the association between LDH and adverse clinical outcomes in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA).


METHODS
All patients were enrolled from the Third China National Stroke Registry (CNSR-III). Adverse outcomes included all-cause death and poor functional outcomes [defined as modified Rankin Scale (mRS) score 3-6 and 2-6] at 3 months and 1 year. Multivariable Cox proportional hazards models and logistic regressions were used to evaluate the association of LDH with risk of all-cause death and poor functional outcomes, respectively.


RESULTS
Among 9,796 included patients, the median [interquartile range (IQR)] of LDH was 175.00 (151.00-205.40) U/L. After adjustment for confounding factors, patients in the highest LDH quartile had a higher risk of all-cause death [hazard ratio (HR), 2.23; 95% confidence interval (CI), 1.27-3.90], and a higher proportion of mRS score 3-6 [odds ratio (OR), 1.54; 95% CI, 1.26-1.90] and mRS score 2-6 (OR, 1.56; 95% CI, 1.32-1.84) at 3 months. We also observed a J-shaped association between LDH and risk of each outcome. Consistent results were found at 1 year.


CONCLUSIONS
Higher LDH levels are independently associated with adverse outcomes in patients with AIS or TIA.
['Wang|Anxin|A|', 'Tian|Xue|X|', 'Zuo|Yingting|Y|', 'Wang|Xuechun|X|', 'Xu|Qin|Q|', 'Meng|Xia|X|', 'Chen|Pan|P|', 'Li|Hao|H|', 'Wang|Yongjun|Y|']
D002681:China D006801:Humans D002546:Ischemic Attack, Transient D000083242:Ischemic Stroke D007770:L-Lactate Dehydrogenase
Lactate dehydrogenase (LDH) acute ischemic stroke (AIS) transient ischemic attack (TIA) all-cause death poor functional outcomes