Dysfunctional RNA binding proteins and stress granules in multiple sclerosis.
Dysfunction of the RNA binding protein (RBP) heterogeneous nuclear ribonuclear protein A1 (hnRNP A1) has been shown to contribute to the pathogenesis of neurodegenerative diseases, but its involvement in multiple sclerosis (MS) is largely unknown. In a neuronal cell line, interferon-γ caused hnRNP A1 nucleocytoplasmic mislocalization; colocalization of hnRNP A1 in stress granules (SGs); and inhibition of translation. Neurons in the brain of a MS patient showed pathogenic RBP dysfunction, including nuclear depletion of hnRNP A1, its mislocalization to the cytoplasm, and its colocalization in SGs. These data indicate a role for dysfunctional hnRNP A1 in the pathogenesis of MS.
['Salapa|Hannah E|HE|', 'Johnson|Chloe|C|', 'Hutchinson|Catherine|C|', 'Popescu|Bogdan F|BF|', 'Levin|Michael C|MC|']
D045744:Cell Line, Tumor D000076245:Heterogeneous Nuclear Ribonucleoprotein A1 D006801:Humans D008297:Male D008875:Middle Aged D009103:Multiple Sclerosis D018384:Oxidative Stress D016601:RNA-Binding Proteins
Stress granules Multiple sclerosis hnRNP A1 Heterogeneous nuclear ribonucleoprotein A1 Interferon gamma Neurodegeneration