Development and validation of an MRI-based radiomic signature for the preoperative prediction of treatment response in patients with invasive functional pituitary adenoma.
PURPOSE
The preoperative prediction of treatment response is important for determining individual treatment strategies for invasive functional pituitary adenoma (IFPA). This study aimed to develop and validate a magnetic resonance imaging (MRI)-based radiomic signature for preoperative prediction of treatment response in IFPA.


METHOD
One hundred and sixty-three patients with IFPA were enrolled and divided into primary (n = 108) and validation cohorts (n = 55) according to time point. IFPA patients were divided into remission and non-remission according to postoperative hormone levels. Radiomic features were extracted from their MR images and a radiomic signature was built using a support vector machine. Subsequently, multivariable logistic regression analysis was used to select the most informative clinical features, and a radiomic model incorporating the radiomic signature and selected clinical features was constructed and used as the final predictive model.


RESULTS
Seven radiomic features were selected to construct the radiomic signature, which achieved an area under the curve (AUC) of 0.834 and 0.808 on the primary and validation cohorts respectively. The radiomic model incorporating the radiomic signature and Knosp grade showed good discrimination abilities and calibration, with AUCs of 0.832 and 0.811 for the primary and validation cohorts respectively. The radiomic signature and radiomic model better estimated the treatment responses of patients with IFPA than our clinical features model. Decision curve analysis showed the radiomic model was clinically useful.


CONCLUSIONS
This radiomic model may help neurosurgeons predict the treatment responses of patients with IFPA before surgery and determine individual treatment strategies.
['Fan|Yanghua|Y|', 'Liu|Zhenyu|Z|', 'Hou|Bo|B|', 'Li|Longfei|L|', 'Liu|Xiaohai|X|', 'Liu|Zehua|Z|', 'Wang|Renzhi|R|', 'Lin|Yusong|Y|', 'Feng|Feng|F|', 'Tian|Jie|J|', 'Feng|Ming|M|']
D000236:Adenoma D000328:Adult D019540:Area Under Curve D005260:Female D006801:Humans D008279:Magnetic Resonance Imaging D008297:Male D010902:Pituitary Gland D010911:Pituitary Neoplasms D011237:Predictive Value of Tests D011300:Preoperative Care D015203:Reproducibility of Results D012189:Retrospective Studies D060388:Support Vector Machine D016896:Treatment Outcome
Radiomics Treatment response Invasive functional pituitary adenoma Magnetic resonance imaging