State of Art of Cancer Pharmacogenomics in Latin American Populations.
Over the past decades, several studies have shown that tumor-related somatic and germline alterations predicts tumor prognosis, drug response and toxicity. Latin American populations present a vast geno-phenotypic diversity due to the great interethnic and interracial mixing. This genetic flow leads to the appearance of complex characteristics that allow individuals to adapt to endemic environments, such as high altitude or extreme tropical weather. These genetic changes, most of them subtle and unexplored, could establish a mutational profile to develop new pharmacogenomic therapies specific for Latin American populations. In this review, we present the current status of research on somatic and germline alterations in Latin America compared to those found in Caucasian and Asian populations.
['López-Cortés|Andrés|A|', 'Guerrero|Santiago|S|', 'Redal|María Ana|MA|', 'Alvarado|Angel Tito|AT|', 'Quiñones|Luis Abel|LA|']
D044466:Asians D051456:Gene Flow D006801:Humans D007843:Latin America D009369:Neoplasms D010597:Pharmacogenetics D020641:Polymorphism, Single Nucleotide D044465:Whites
cancer pharmacogenomics Latin America pharmacogenetics precision medicine single nucleotide polymorphism