A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster.
Hippo-like pathways are ancient signaling modules first identified in yeasts. The best-defined metazoan module forms the core of the Hippo pathway, which regulates organ size and cell fate. Hippo-like kinase modules consist of a Sterile 20-like kinase, an NDR kinase, and non-catalytic protein scaffolds. In the Hippo pathway, the upstream kinase Hippo can be activated by another kinase, Tao-1. Here, we delineate a related Hippo-like signaling module that Tao-1 regulates to control tracheal morphogenesis in Drosophila melanogaster. Tao-1 activates the Sterile 20-like kinase GckIII by phosphorylating its activation loop, a mode of regulation that is conserved in humans. Tao-1 and GckIII act upstream of the NDR kinase Tricornered to ensure proper tube formation in trachea. Our study reveals that Tao-1 activates two related kinase modules to control both growth and morphogenesis. The Hippo-like signaling pathway we have delineated has a potential role in the human vascular disease cerebral cavernous malformation.
['Poon|Carole L C|CLC|', 'Liu|Weijie|W|', 'Song|Yanjun|Y|', 'Gomez|Marta|M|', 'Kulaberoglu|Yavuz|Y|', 'Zhang|Xiaomeng|X|', 'Xu|Wenjian|W|', 'Veraksa|Alexey|A|', 'Hergovich|Alexander|A|', 'Ghabrial|Amin|A|', 'Harvey|Kieran F|KF|']
D000818:Animals D029721:Drosophila Proteins D004331:Drosophila melanogaster D000081410:Germinal Center Kinases D057809:HEK293 Cells D006801:Humans D009024:Morphogenesis D017346:Protein Serine-Threonine Kinases D015398:Signal Transduction D014132:Trachea
signaling morphogenesis Hippo-like pathways kinases trachea tubular networks