Antiapoptotic Bcl-2 protein as a potential target for cancer therapy: A mini review.
Bcl-2, an antiapoptotic protein, is considered as a potential target in cancer treatment since its oncogenic potential has been proven and is well documented. Antisense technology and RNA interference (RNAi) have been used to reduce the expression of the Bcl-2 gene in many types of cancer cells and are effective as adjuvant therapy along with the chemotherapeutic agents. The lack of appropriate delivery systems is considered to be the main hurdle associated with the RNAi. In this review, we discuss the antiapoptotic Bcl-2 protein, its oncogenic potential, and various approaches utilized to target Bcl-2 including suitable delivery systems employed for successful delivery of siRNA.
['Jagani|Hitesh|H|', 'Kasinathan|Narayanan|N|', 'Meka|Sreenivasa Reddy|SR|', 'Josyula|Venkata Rao|VR|']
D000818:Animals D015316:Genetic Therapy D006801:Humans D009369:Neoplasms D019253:Proto-Oncogene Proteins c-bcl-2 D034622:RNA Interference D034741:RNA, Small Interfering
Bcl-2 cancer RNA interference Antisense oligonucleotide apoptosis drug delivery