Genetic diversity of Trichomonas vaginalis clinical isolates from Henan province in central China.
Trichomonas vaginalis is a flagellated protozoan parasite that infects the human urogenital tract, causing the most common non-viral, sexually transmitted disease worldwide. In this study, genetic variants of T. vaginalis were identified in Henan Province, China. Fragments of the small subunit of nuclear ribosomal RNA (18S rRNA) were amplified from 32 T. vaginalis isolates obtained from seven regions of Henan Province. Overall, 18 haplotypes were determined from the 18S rRNA sequences. Each sampled population and the total population displayed high haplotype diversity (Hd), accompanied by very low nucleotide diversity (Pi). In these molecular genetic variants, 91.58% genetic variation was derived from intra-regions. Phylogenetic analysis revealed no correlation between phylogeny and geographic distribution. Demographic analysis supported population expansion of T. vaginalis isolates from central China. Our findings showing moderate-to-high genetic variations in the 32 isolates of T. vaginalis provide useful knowledge for monitoring changes in parasite populations for the development of future control strategies.
['Mao|Meng|M|', 'Liu|Hui Li|HL|']
D000328:Adult D002681:China D016000:Cluster Analysis D016054:DNA, Protozoan D004275:DNA, Ribosomal D005260:Female D014644:Genetic Variation D006801:Humans D010802:Phylogeny D016133:Polymerase Chain Reaction D012337:RNA, Ribosomal, 18S D017422:Sequence Analysis, DNA D014245:Trichomonas Infections D014246:Trichomonas vaginalis D055815:Young Adult
China 18S rRNA, Genetic variation, Trichomonas vaginalis ,