Synthesis of a novel water-soluble zinc phthalocyanine and its CT DNA-damaging studies.
A novel 3-(4-methoxybenzylamino) propanoic acid substituted water-soluble zinc phthalocyanine (CNPcZn) was synthesized. The interaction between CNPcZn with calf thymus DNA (CT DNA) was studied using spectroscopic methods. The studies indicated that CNPcZn has strong affinity to CT DNA, and furthermore, CNZnPc showed excellent photodamaging activity to CT DNA. Above results indicated that such CNPcZn has great potential to be used as an effective photosensitizer in the field of photodynamic therapy.
['Wang|Tianhui|T|', 'Wang|Ao|A|', 'Zhou|Lin|L|', 'Lu|Shan|S|', 'Jiang|Weiwei|W|', 'Lin|Yun|Y|', 'Zhou|Jiahong|J|', 'Wei|Shaohua|S|']
D000818:Animals D000873:Anthracenes D002417:Cattle D004247:DNA D053837:DNA Cleavage D004249:DNA Damage D004996:Ethidium D007211:Indoles D054833:Isoindoles D007700:Kinetics D008027:Light D009691:Nucleic Acid Denaturation D009942:Organometallic Compounds D011422:Propionates D012995:Solubility D012996:Solutions D013050:Spectrometry, Fluorescence D013056:Spectrophotometry, Ultraviolet D013816:Thermodynamics D014867:Water D017967:Zinc Compounds
Water-soluble Phthalocyanine CT DNA Photodynamic therapy Singlet oxygen