Successful treatment of Ureaplasma-induced hyperammonemia syndrome post-lung transplant.
Hyperammonemia, in the absence of significant liver dysfunction, is an uncommon but often fatal occurrence following orthotopic lung transplant. Prior reports have provided evidence to support Ureaplasma species as an etiology for this syndrome. This case report describes an individual post-lung transplant, treated emperically with doxycycline along with other measures to lower ammonia levels, at the time hyperammonemia with encephalopathy was recognized. The patient clinically improved. Ureaplasma species were subsequently identified using 16S ribosomal RNA gene PCR/sequencing of pleural fluid, and by culture of bronchoalveolar (BAL) fluid. This case provides further support for empiric treatment of Ureaplasma species upon recognition of hyperammonemia syndrome post-lung transplant.
['Matson|Kristine M|KM|http://orcid.org/0000-0002-4853-6125', 'Sonetti|David A|DA|']
D000890:Anti-Infective Agents D001992:Bronchoalveolar Lavage Fluid D006084:Graft Rejection D006801:Humans D022124:Hyperammonemia D016867:Immunocompromised Host D007165:Immunosuppression Therapy D016040:Lung Transplantation D008297:Male D008875:Middle Aged D010654:Phenylbutyrates D011183:Postoperative Complications D029424:Pulmonary Disease, Chronic Obstructive D013577:Syndrome D016896:Treatment Outcome D014509:Ureaplasma D016869:Ureaplasma Infections
Hyperammonemia lung transplantation Ureaplasma