Adaptation of the Cutaneous Microcirculation in Preterm Neonates.
OBJECTIVE
Transition from fetal to neonatal circulation is characterized by multiple hemodynamic changes. The role of the microcirculation in this process is underexposed. Visualizing the cutaneous microcirculation can help us understand peripheral perfusion in a noninvasive manner.


METHODS
Cutaneous microcirculation of term and preterm infants born below 32 weeks of GA was measured in the first month of life using IDF imaging. Linear mixed modeling was used to identify clinical variables which influence the cutaneous microcirculation.


RESULTS
Sixty preterm and 33 term infants were included. TVD of preterm infants significantly decreased in the first month of life (31.7 mm/mm(2)  day 1 vs 27.9 mm/mm(2)  day 28), but remained significantly higher compared to TVD of term infants on day 1 (25.8 mm/mm(2) ). Besides postnatal age, no clinical variables were associated with TVD. Infants born SGA had significantly higher TVD values directly after birth than those born appropriate for GA (35.4 mm/mm(2) vs 31.6 mm/mm(2) ; p = 0.015).


CONCLUSIONS
TVD decreases in the first month after birth and is higher in preterm infants compared to those born term. Differences in antenatal oxygen exposure might explain the adaptation of the microcirculation.
['van Elteren|Hugo A|HA|', 'de Jonge|Rogier C J|RC|', 'van Rosmalen|Joost|J|', 'Ince|Can|C|', 'Reiss|Irwin K M|IK|']
D000222:Adaptation, Physiological D001808:Blood Vessels D005260:Female D005865:Gestational Age D006801:Humans D007231:Infant, Newborn D007234:Infant, Premature D008297:Male D008833:Microcirculation D010100:Oxygen D012867:Skin
adaptation cutaneous preterm neonates incident dark field