Outpatient Cardiac Rehabilitation Suppresses Deterioration of Renal Function in Patients ≥75 Years of Age With Heart Disease.
BACKGROUND
This study investigated the effect of outpatient cardiac rehabilitation (OCR) and physical activity on the estimated glomerular filtration rate based on serum cystatin C (eGFRcys) in patients with heart disease (HD) aged ≥75 years.Methods and Results:This non-randomized prospective intervention study involved 136 patients (non-OCR group, n=66; OCR group, n=70), 55 of whom were aged ≥75 years (non-OCR group, n=29; OCR group, n=26). Renal function (eGFRcys) was evaluated at discharge and 3 months thereafter. A linear mixed model (LMM) was used to assess changes in renal function over time. The hospital readmission rate within 3 months after discharge was also evaluated. LMM analysis showed that the change in eGFRcys was -2.27 and +0.48 mL/min/1.73 m2in the non-OCR and OCR groups, respectively (F=2.960, P=0.022). Further, among patients aged ≥75 years in the non-OCR and OCR groups, the change in eGFRcys was -3.83 and -1.08 mL/min/1.73 m2, respectively (F=2.719, P=0.039). The proportion of patients aged ≥75 years who were rehospitalized due to exacerbation of HD was 16.9% (n=10) and 6.7% (n=2) in the non-OCR and OCR groups, respectively.


CONCLUSIONS
Among patients with HD aged ≥75 years, participation in OCR reduces the decline in renal function and hospital readmission rates.
['Sasamoto|Yuichiro|Y|', 'Endo|Noriko|N|', 'Kanazawa|Kohko|K|', 'Utsumi|Taeko|T|', 'Takahashi|Tomomi|T|', 'Endo|Yosuke|Y|', 'Nanba|Makoto|M|', 'Takeda|Hiroto|H|', 'Takano|Tomohiro|T|', 'Takahashi|Koki|K|', 'Tanji|Masahiro|M|', 'Kohzuki|Masahiro|M|']
Physical activity Glomerular filtration rate Cystatin C Kidney disease Patient readmission