Steroid-free and steroid withdrawal protocols in heart transplantation: the review of literature.
Corticosteroids (CSs) are still the mainstay of induction, rescue, and maintenance in heart transplantation (HTx). However, their use is associated with significant and well-documented side effects usually related to the dose administered and the duration of therapy. Moreover, CSs interfere with the recipient's quality of life and with the active process of graft tolerance. Physicians have been exploring ways to avoid or reduce CSs in association with other immunosuppressive drugs, minimizing side effects and costs. The regimens are classified as steroid-free or steroid withdrawal protocols. The studies analyzed in this review come to similar conclusions as benefits and adverse consequences: steroid-free protocols should be advisable and mandatory in pediatric patients, insulin-dependent diabetes mellitus (IDDM), presence of infection, familial metabolic disorders/obesity, severe osteoporosis, and in the elderly. On the other hand, steroid withdrawal can be successfully achieved in 50-80%, with late better than early withdrawal, no increase in rejection-related mortality, no adverse impact on survival, and probably a better quality of live. Safety and efficacy can certainly be improved by an individualized approach to the transplant recipient.
['Baraldo|Massimo|M|', 'Gregoraci|Giorgia|G|', 'Livi|Ugolino|U|']
D000305:Adrenal Cortex Hormones D004305:Dose-Response Relationship, Drug D004334:Drug Administration Schedule D005260:Female D006084:Graft Rejection D006085:Graft Survival D016027:Heart Transplantation D006801:Humans D007166:Immunosuppressive Agents D008297:Male D011379:Prognosis D016032:Randomized Controlled Trials as Topic D018570:Risk Assessment D014181:Transplantation Immunology D023001:Transplantation Tolerance D016896:Treatment Outcome D028761:Withholding Treatment
steroid-free steroid withdrawal heart transplantation steroid minimization