Mud in the blood: the role of protein-mineral complexes and extracellular vesicles in biomineralisation and calcification.
Protein-mineral interaction is known to regulate biomineral stability and morphology. We hypothesise that fluid phases produce highly dynamic protein-mineral complexes involved in physiology and pathology of biomineralisation. Here, we specifically focus on calciprotein particles, complexes of vertebrate mineral-binding proteins and calcium phosphate present in the systemic circulation and abundant in extracellular fluids - hence the designation of the ensuing protein-mineral complexes as "mud in the blood". These complexes exist amongst other extracellular particles that we collectively refer to as "the particle zoo".
['Jahnen-Dechent|Willi|W|', 'Büscher|Andrea|A|', 'Köppert|Sina|S|', 'Heiss|Alexander|A|', 'Kuro-O|Makoto|M|', 'Smith|Edward R|ER|']
D000077320:Biomineralization D002113:Calcification, Physiologic D002114:Calcinosis D002118:Calcium D002130:Calcium Phosphates D000067128:Extracellular Vesicles D006801:Humans D008903:Minerals D011485:Protein Binding D011506:Proteins
Extracellular vesicles Biomineralization Calciprotein particles Fetuin-A