Effect of Helicobacter pylori infection and its eradication on gastric regenerating atypia in 22 133 subjects.
BACKGROUND AND AIM
The aim of this study was to identify factors affecting persistent gastric regenerating atypia and determine the effect of Helicobacter pylori eradication on the course of this lesion.


METHODS
In cross-sectional setting, comprehensive health check-up subjects who underwent both endoscopy and H. pylori test from 2001 to 2009 were included. The association between H. pylori and gastric regenerating atypia was evaluated. In cohort setting, patients with regenerating atypia who underwent H. pylori test from 2001 to 2013 were included. Factors affecting positive pathology (persistent regenerating atypia or new development of neoplasm) in patients with regenerating atypia at baseline were investigated.


RESULTS
In cross-sectional setting, regenerating atypia was observed in 1.1% (241/22 133). H. pylori infection was associated with gastric regenerating atypia (adjusted odds ratio, 1.47; 95% confidence interval [CI], 1.12-1.91). In cohort setting, 310 patients with regenerating atypia were finally eligible. Positive pathology rate during follow up was 16.1% (15/93) in the persistent infection group, 2.8% (3/106) in successful eradication group, and 4.5% (5/111) in baseline H. pylori-negative group. Persistent H. pylori infection increased the risk of positive pathology (adjusted risk ratio [RR], 7.18; 95% CI, 1.95-26.48) compared to H. pylori eradication group. Persistent H. pylori infection increased the risk of regenerative atypia (adjusted RR, 5.70; 95% CI, 1.46-22.17) and new neoplasm (adjusted RR, 10.74; 95% CI, 1.10-105.17) compared to baseline negative H. pylori.


CONCLUSIONS
H. pylori infection is an independent risk factor for gastric regenerating atypia. Eradication of H. pylori seems helpful for regression of regenerating atypia.
['Nam|Ji Hyung|JH|https://orcid.org/0000-0002-7083-7581', 'Nam|Su Youn|SY|https://orcid.org/0000-0002-5568-7714', 'Park|Bum Joon|BJ|', 'Ryu|Kum Hei|KH|']
D015331:Cohort Studies D003430:Cross-Sectional Studies D005260:Female D005753:Gastric Mucosa D016481:Helicobacter Infections D016480:Helicobacter pylori D006801:Humans D008297:Male D008875:Middle Aged D013274:Stomach Neoplasms D013276:Stomach Ulcer
Helicobacter pylori regenerating atypia H. pylori eradication