Indole diterpenoids from the endophytic fungus Drechmeria sp. as natural antimicrobial agents.
A fungal strain, Drechmeria sp., was isolated from the root of Panax notoginseng. Totally, seven new indole diterpenoids, drechmerins A-G (1-7), were isolated from the fermentation broth of Drechmeria sp. together with four known analogues (8-11). Their structures were determined on the basis of 1D and 2D NMR and electronic circular dichroism (ECD) spectroscopic analyses as well as theoretical calculations. All the isolated compounds were evaluated for their antimicrobial activities against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin B (2) displayed antimicrobial activity against C. albicans with an MIC value of 12.5 μg/mL. Molecular docking was used to investigate interactions of peptide deformylase with compounds 1-3, 5-7, 9, and 10.
['Zhao|Jian-Chao|JC|', 'Wang|Ya-Li|YL|', 'Zhang|Tian-Yuan|TY|', 'Chen|Zhong-Jian|ZJ|', 'Yang|Tian-Mei|TM|', 'Wu|Ying-Ying|YY|', 'Sun|Cheng-Peng|CP|', 'Ma|Xiao-Chi|XC|', 'Zhang|Yi-Xuan|YX|']
D000900:Anti-Bacterial Agents D000890:Anti-Infective Agents D002176:Candida albicans D004224:Diterpenes D006999:Hypocreales D007211:Indoles D008826:Microbial Sensitivity Tests D015394:Molecular Structure D011550:Pseudomonas aeruginosa D013211:Staphylococcus aureus
Indole diterpenoids Drechmeria sp. Theoretical calculation Antimicrobial activity