Therapeutics for tendon regeneration: a multidisciplinary review of tendon research for improved healing.
Tendon injuries, known as tendinopathies, are common musculoskeletal injuries that affect a wide range of the population. Canonical tendon healing is characterized by fibrosis, scar formation, and the loss of tissue mechanical and structural properties. Understanding the regenerative tendon environment is an area of increasing interest in the field of musculoskeletal research. Previous studies have focused on utilizing individual elements from the fields of biomechanics, developmental biology, cell and growth factor therapy, and tissue engineering in an attempt to develop regenerative tendon therapeutics. Still, the specific mechanism for regenerative healing remains unknown. In this review, we highlight some of the current approaches of tendon therapeutics and elucidate the differences along the tendon midsubstance and enthesis, exhibiting the necessity of location-specific tendon therapeutics. Furthermore, we emphasize the necessity of further interdisciplinary research in order to reach the desired goal of fully understanding the mechanisms underlying regenerative healing.
['Paredes|J J|JJ|', 'Andarawis-Puri|Nelly|N|']
D000818:Animals D064987:Cell- and Tissue-Based Therapy D003131:Combined Modality Therapy D006801:Humans D036341:Intercellular Signaling Peptides and Proteins D012038:Regeneration D013708:Tendon Injuries D023822:Tissue Engineering D054457:Tissue Scaffolds D014945:Wound Healing
therapeutics tendon regeneration healing