Transcranial magnetic stimulation with acepromazine or dexmedetomidine in combination with levomethadone/fenpipramide in healthy Beagle dogs.
The aim of this study was to evaluate the influence of two sedation protocols on transcranial magnetic motor evoked potentials (TMMEPs) after transcranial magnetic stimulation in medium sized dogs. Onset latencies and peak-to-peak amplitudes, elicited in the extensor carpi radialis and cranial tibial muscles, were analysed in 10 healthy Beagles that received either acepromazine or dexmedetomidine in combination with levomethadone/fenpipramide, in a crossover design. Similar TMMEP recordings could be made using both sedation protocols at 80-90% stimulation intensity; however, there were significantly shorter onset latencies with the acepromazine-levomethadone/fenpipramide protocol at 100% stimulation intensity. Reference values were established and it was concluded that both drug combinations are feasible for measuring TMMEPs in medium sized dogs.
['Amendt|H-L|HL|', 'Siedenburg|J S|JS|', 'Steffensen|N|N|', 'Söbbeler|F J|FJ|', 'Schütter|A|A|', 'Tünsmeyer|J|J|', 'Rohn|K|K|', 'Kästner|S B R|SB|', 'Tipold|A|A|', 'Stein|V M|VM|']
D000075:Acepromazine D000701:Analgesics, Opioid D000818:Animals D016292:Conscious Sedation D018592:Cross-Over Studies D020927:Dexmedetomidine D004158:Diphenylacetic Acids D004285:Dogs D019054:Evoked Potentials, Motor D006993:Hypnotics and Sedatives D012016:Reference Values D050781:Transcranial Magnetic Stimulation
Transcranial magnetic stimulation Acepromazine Dexmedetomidine Magnetic motor evoked potentials Canine