Associations between maternal helminth and malaria infections in pregnancy and clinical malaria in the offspring: a birth cohort in entebbe, Uganda.
BACKGROUND
Helminth and malaria coinfections are common in the tropics. We investigated the hypothesis that prenatal exposure to these parasites might influence susceptibility to malaria in childhood.


METHODS
In a birth cohort of 2345 mother-child pairs in Uganda, maternal helminth and malaria infection status was determined during pregnancy, and childhood malaria episodes were recorded from birth to age 5 years. We examined associations between maternal infections and malaria in the offspring.


RESULTS
Common maternal infections were hookworm (45%), Mansonella perstans (21%), Schistosoma mansoni (18%), and Plasmodium falciparum (11%). At age 5 years, 69% of the children were still under follow-up. The incidence of malaria was 34 episodes per 100 child-years, and the mean prevalence of asymptomatic malaria at annual visits was 5.4%. Maternal hookworm and M. perstans infections were associated with an increased rate of childhood clinical malaria (adjusted hazard ratio [aHR], 1.24, 95% confidence interval [CI], 1.10-1.41; aHR, 1.20, 95% CI, 1.05-1.38, respectively). S. mansoni infection had no consistent association with childhood malaria.


CONCLUSIONS
This is the first report of an association between helminth infections in pregnancy and malaria in the offspring and indicates that helminth infections in pregnancy may increase the burden of childhood malaria morbidity.
['Ndibazza|Juliet|J|', 'Webb|Emily L|EL|', 'Lule|Swaib|S|', 'Mpairwe|Harriet|H|', 'Akello|Miriam|M|', 'Oduru|Gloria|G|', 'Kizza|Moses|M|', 'Akurut|Helen|H|', 'Muhangi|Lawrence|L|', 'Magnussen|Pascal|P|', 'Vennervald|Birgitte|B|', 'Elliott|Alison|A|']
D000328:Adult D002675:Child, Preschool D015331:Cohort Studies D060085:Coinfection D005260:Female D006373:Helminthiasis D006801:Humans D015994:Incidence D007223:Infant D007231:Infant, Newborn D008288:Malaria D008297:Male D011247:Pregnancy D015597:Pregnancy Complications, Parasitic D014454:Uganda
helminths malaria pregnancy coinfections childhood