Colorectal Cancer Screening Recommendations and Outcomes in Lynch Syndrome.
Screening for colorectal cancer (CRC) in Lynch syndrome enables early detection and likely cancer prevention. CRC screening guidelines have evolved from universal to gene-specific recommendations based on lifetime neoplasia risks. Regular screening for Lynch syndrome reduces CRC-related mortality; however, high CRC incidence during regular colonoscopy screening suggests the possibility of nonpolypoid carcinogenesis. Colonoscopy is the primary modality for screening for Lynch syndrome with mixed and emerging data on quality metrics, chromoendoscopy, artificial intelligence, and nonendoscopic modalities. Screening adherence varies across studies. In this review, we present the current state of CRC screening recommendations, outcomes, and modalities in Lynch syndrome.
['Drogan|Christine|C|', 'Kupfer|Sonia S|SS|']
D001185:Artificial Intelligence D003113:Colonoscopy D015179:Colorectal Neoplasms D003123:Colorectal Neoplasms, Hereditary Nonpolyposis D055088:Early Detection of Cancer D006801:Humans
Colorectal cancer Screening Lynch syndrome Quality Chromoendoscopy Artificial intelligence