TBAI/TBHP-Promoted Generation of Malonyl Radicals: Oxidative Coupling with Styrenes Leads to γ-Keto Diesters.
A metal-free protocol for oxidative coupling of malonic esters with styrenes to form γ-keto diesters has been developed. Key to the success of this process is the generation of malonyl radicals from unfunctionalized malonic esters under organo-catalysis conditions with TBAI and TBHP. This process tolerates both terminal and internal olefins with diverse malonic esters. It provides a new green metal-free alternative to traditional metal mediated process for generation of malonyl radicals and there by γ-keto diesters.
['Chowdhury|Soumyadeep Roy|SR|', 'Hoque|Injamam Ul|IU|', 'Maity|Soumitra|S|http://orcid.org/0000-0003-0944-8162']
malonyl radical oxidative coupling TBAI/TBHP ketodiester metal-free conditions