Epicardial adipose tissue thickness in children and adolescents with cardiometabolic risk factors.
OBJECTIVE
To assess the relationship of epicardial adipose tissue (EAT) thickness with cardiometabolic risk factors (CRFs) in children and adolescents.


METHODS
Seventy-seven subjects of both sexes aged 7-18 years were selected. Medical history, clinical parameters, and glucose, insulin, and lipid levels were collected. EAT thickness was measured using transthoracic echocardiography. Study subjects were divided into two groups based on whether they had less than two or two or more CRFs.


RESULTS
The group with two or more CRFs had higher EAT thickness, insulin, and HOMA-IR values (P<.05). EAT thickness showed a statistically significant positive correlation with body mass index (BMI) (r=0.561, P=.0001), waist circumference (r=.549, P=.0001), systolic blood pressure (SBP) (r=.256, P=.028), insulin (r=0.408, P=.0001), and HOMA-IR (r=.325, P=.005). However, these correlations were not significant after adjustment for BMI. The cut-off point for EAT thickness as predictor of two or more CRFs was 3.17mm. The risk (odds ratio) of having two or more CRFs if EAT thickness was >3.17mm was 3.1 (95% CI: 1.174-8.022). BMI was the independent variable that most affected EAT thickness and the presence of two or more CRFs.


CONCLUSION
In this group of children and adolescents, the relationship of EAT thickness with CRFs was found to be dependent on BMI.
['Reyes|Yubriangel|Y|', 'Paoli|Mariela|M|', 'Camacho|Nolis|N|', 'Molina|Yudisay|Y|', 'Santiago|Justo|J|', 'Lima-Martínez|Marcos M|MM|']
D000273:Adipose Tissue D000293:Adolescent D001794:Blood Pressure D002648:Child D004452:Echocardiography D005260:Female D006331:Heart Diseases D006801:Humans D007328:Insulin D008297:Male D008659:Metabolic Diseases D010496:Pericardium D012307:Risk Factors D055105:Waist Circumference
Epicardial adipose tissue Children and adolescents Cardiometabolic risk factors Epicardial fat Factores de riesgo cardiometabólico Grasa epicárdica Niños y adolescentes Tejido adiposo epicárdico