Toxicity and Genotoxicity of Three Antimicrobials Commonly Used in Veterinary Medicine.
The toxicity of chlortetracycline (CTC), oxytetracycline (OTC) and enrofloxacin (ENF) was tested on two green algal species: the international standard Pseudokirchneriella subcapitata and the native Argentine species Ankistrodesmus fusiformis. All three antibiotics inhibited the algal growth. The most sensitive species was P. subcapitata, for which the EC50 for CTC, OTC and ENF were 1.19 ± 0.53, 0.92 ± 0.30 and 5.18 ± 3.80 mg L-1, respectively. The EC50 for A. fusiformis, were 3.23 ± 0.53, 7.15 ± 2.69 and 10.6 ± 1.28 mg L-1, respectively. The genotoxicity of these veterinary antibiotics was also assessed using chromosome aberration (CA) and micronuclei (MN) induction in Allium cepa roots. Three concentrations were tested (0.1, 1 and 10 mg L-1). Only ENF at 1 and 10 mg L-1 showed any significant MN induction. These data revealed that CTC, OTC and ENF could cause toxicity on green algae, whereas ENF could cause genotoxicity on A. cepa plants.
['Magdaleno|Anahí|A|', 'Carusso|Sofía|S|', 'Moretton|Juan|J|']
D000890:Anti-Infective Agents D000460:Chlorophyta D002751:Chlortetracycline D004249:DNA Damage D000077422:Enrofloxacin D024841:Fluoroquinolones D010118:Oxytetracycline D019155:Veterinary Drugs
Chlortetracycline Oxytetracycline Enrofloxacin Pseudokirchneriella subcapitata Allium cepa