The Value of Neutrophil:Lymphocyte Ratio and Platelet:Lymphocyte Ratio in Predicting Clinical Severity in Children with Carbon Monoxide Poisoning.
OBJECTIVE
To compare the values of neutrophil:lymphocyte ratio (NLR), platelet:lymphocyte ratio (PLR), and mean platelet volume (MPV) with carboxyhemoglobin (COHb) and lactate levels in children with acute CO intoxication.


METHODS
In this retrospective study, the patients were divided into two groups: mild-to-moderate carbon monoxide poisoning (COP) (COHb 10%-20%) and severe COP (COHb > 20%) according to the COHb levels in the application. All patients were compared in terms of NLR, PLR, and MPV parameters according to the severity of poisoning and the high lactate levels (≥ 2.2 mmol/L).


RESULTS
A total of 261 children with COP were included in the study. The number of patients with mild-to-moderate COP was 183 (70.1%), and the number of patients with severe COP was 78 (29.9%). NLR [2.57 (3.27), 1.65 (1.93), (p = 0.001)] and PLR [123.0 (88.24), 92.8 (54.1), (p = 0.001)] values of mild-to-moderate COP were statistically significantly lower than the severe COP group. In the group with high lactate level, PLR values were significantly lower [120.1 (71.9), 100.2 (85.4), (p = 0.017)]. NLR and PLR values were found to be predictive of severe COP.


CONCLUSION
NLR and PLR can be used for detection of clinical severity in patients with COP. PLR can be used in conjunction with lactate levels to detect tissue-level exposure in patients with COP.
['Bağcı|Zafer|Z|http://orcid.org/0000-0003-4776-7236', 'Arslan|Abdullah|A|', 'Arslan|Derya|D|']
D001792:Blood Platelets D002249:Carbon Monoxide Poisoning D002648:Child D006801:Humans D018655:Lymphocyte Count D008214:Lymphocytes D009504:Neutrophils D010976:Platelet Count D012189:Retrospective Studies
Neutrophil:Lymphocyte ratio Platelet:Lymphocyte ratio Carbon monoxide poisoning Lactate