Tragopogon porrifolius improves serum lipid profile and increases short-term satiety in rats.
Tragopogon porrifolius (white salsify) is an edible plant commonly used in folk medicine in Lebanon and neighbouring countries. This study investigates the effect of the aqueous extract of the aerial part of T. porrifolius on lipemia and appetite regulation using a rat model. Food intake, abdominal fat percentage, blood lipid profile, liver weight and liver enzymes were assessed following 4 weeks of extract intake via drinking water (50, 100, or 250 mg/kg body weight) in standard high-carbohydrate and high-fat dietary conditions. In a separate study, the short term effect of a preload of T. porrifolius extract on food intake was evaluated. Results showed that consumption of the plant extract for a period of four weeks resulted in a marked improvement of the lipid profile (triglycerides, total cholesterol, LDL and HDL cholesterol). Body weight, food intake and intra-abdominal fat were also lower in animals given the plant extract (100 and 250 mg/kg). In addition, T. porrifolius extract preload produced a dose dependent decrease in food intake observed over 24h. The intake of T. porrifolius aqueous extract therefore improved lipemia and increased satiety in rats with no visible adverse effects.
['Zeeni|Nadine|N|', 'Daher|Costantine F|CF|', 'Saab|Lea|L|', 'Mroueh|Mohamad|M|']
D050153:Abdominal Fat D000818:Animals D001066:Appetite D001069:Appetite Regulation D001823:Body Composition D001835:Body Weight D002784:Cholesterol D059305:Diet, High-Fat D004040:Dietary Carbohydrates D004041:Dietary Fats D004435:Eating D002149:Energy Intake D006949:Hyperlipidemias D008055:Lipids D008297:Male D008517:Phytotherapy D010936:Plant Extracts D051381:Rats D017207:Rats, Sprague-Dawley D012527:Satiation D012528:Satiety Response D031188:Tragopogon D014280:Triglycerides
Tragopogon porrifolius Lipid profile Satiety Cholesterol High-fat diet