Comparison of Hydroxyethyl starch 130/0.4 (6%) with commonly used agents in an experimental Pleurodesis model.
BACKGROUND
Hydroxyethyl Starch (HES) 130/0.4 (6%) is a commonly used intravascular volume expander with anti-inflammatory and antioxidant properties. In this study, we aimed to compare the histopathologic activity of HES 130/0.4 (6%) with various widely-used agents in pleurodesis.


METHODS
Forty male Wistar-Albino rats were divided into five groups: controls, povidone-iodine recipients (PI group), sterile talcum recipients (Talcum group), autologous blood recipients (AB group) and HES 130/0.4 (6%) recipients (HES group). Thirty days after application of agents, pleural and lung tissues were resected. Evaluation was performed via macroscopic scoring (adhesion) and specimens were stained with H&E for microscopic examination (inflammation and fibrosis).


RESULTS
HES recipients had significantly higher adhesion compared to controls (lower grade 0, higher grade 1 frequency vs. controls), they were found to have significantly lower frequency of grade 2 adhesion (vs. PI, Talc and AB) and grade 3 adhesion (vs. AB), indicating that the adhesion-generating properties of HES were only superior to the control group. HES recipients had significantly higher inflammatory grades compared to controls (lower grade 0, higher grade 1 frequency), while they had lower grades compared to the PI, Talc and AB groups. Although the PI, Talc and AB groups were statistically similar in most comparisons, we observed a trend towards higher success with the use of Talc and especially AB.


CONCLUSION
Our results do not support a role for HES in pleurodesis. We believe that the autologous blood method remains as an effective and successful procedure without side effects.
['Kapicibasi|Hasan Oğuz|HO|http://orcid.org/0000-0001-7275-1039', 'Kiraz|Hasan Ali|HA|https://orcid.org/0000-0002-8548-124X', 'Gök|Nazli Demir|ND|https://orcid.org/0000-0002-9184-6065']
D000818:Animals D006895:Hydroxyethyl Starch Derivatives D008297:Male D010994:Pleura D018700:Pleurodesis D051381:Rats D017208:Rats, Wistar D013627:Talc D013908:Thoracotomy D000267:Tissue Adhesions
Hydroxyethyl starch Pleurodesis Parietal-visceral pleura