NPC-phagy: selective autophagy of the nuclear pore complexes.
Selective autophagy is critical for the regulation of cellular homeostasis in organisms from yeast to humans. This process is a specific degradation pathway for a wide variety of substrates including unwanted cytosolic components, such as protein aggregates, damaged and/or superfluous organelles, and pathogens. However, it has been less clear as to whether a protein complex or substructure of an organelle can be targeted for removal by selective autophagy. One example of such a substrate is the nuclear pore complex (NPC), a large macromolecular assembly that is present throughout the nuclear envelope. Here, we highlight two recent studies that demonstrate for the first time that NPCs are targeted for vacuolar degradation through selective autophagy.


ABBREVIATIONS
AIM: Atg8-interacting motif; NE: nuclear envelope; NPC: nuclear pore complex; Nup: nucleoporin; PMN/micronucleophagy: piecemeal microautophagy of the nucleus.
['Yin|Zhangyuan|Z|', 'Klionsky|Daniel J|DJ|0000-0002-7828-8118']
D001343:Autophagy D002467:Cell Nucleus D003600:Cytosol D000080550:Macroautophagy D009685:Nuclear Envelope D022022:Nuclear Pore D028861:Nuclear Pore Complex Proteins D015388:Organelles D012441:Saccharomyces cerevisiae D029701:Saccharomyces cerevisiae Proteins D014617:Vacuoles
NPC-phagy selective autophagy Autophagy nuclear pore complex Nup159 cargo receptor