Cytotoxic compound triacremoniate from Marine Fungus Acremonium citrinum. MMF4.
Two new compounds, triacremoniate (1) and dietziamide C (2) along with known compounds β-Adenosine (3) and acrepyrone A (4) were obtained from the mangrove-derived fungus Acremonium citrinum. MMF4. Their structures were unambiguously determined by extensive spectroscopic methods, including UV, IR, HRESIMS and NMR. Triacremoniate (1) can promote apoptosis of HeLa cells by increasing the PARP cleavage and the phosphorylation of JNK and p38.
['Wang|Xiao-Yao|XY|', 'Ye|Xian-Sheng|XS|', 'Gao|Shuo|S|', 'Liu|Jin-Xi|JX|', 'Tian|Wen-Jing|WJ|', 'Wang|Guang-Hui|GH|', 'Chen|Hai-Feng|HF|', 'Lin|Ting|T|']
D000164:Acremonium D000970:Antineoplastic Agents D001688:Biological Products D002681:China D006367:HeLa Cells D006801:Humans D015394:Molecular Structure D018517:Plant Roots D043982:Rhizophoraceae
Acremonium citrinum Apoptosis HeLa PARP JNK P38