A Flexible Strategy for Modular Synthesis of Curcuminoid-BF2 /Curcuminoid Pairs and Their Comparative Antiproliferative Activity in Human Cancer Cell Lines.
A facile protocol that enables synthetic interconversion of CUR-BF2 and CUR compounds is described that significantly widens the preparative scope of curcuminoids, providing access to larger libraries of compounds, thus enabling comparative antiproliferative and apoptotic study of a larger library of synthetic analogs in cancer cell lines.
['Abonia|Rodrigo|R|', 'Laali|Kenneth K|KK|0000-0002-0294-844X', 'Raja Somu|Dawn|D|', 'Bunge|Scott D|SD|', 'Wang|Esther C|EC|']
D000970:Antineoplastic Agents D017209:Apoptosis D045744:Cell Line, Tumor D049109:Cell Proliferation D036381:Diarylheptanoids D004305:Dose-Response Relationship, Drug D004354:Drug Screening Assays, Antitumor D006801:Humans D015394:Molecular Structure D013329:Structure-Activity Relationship
comparative antiproliferative activity synthetic interconversion CUR-BF2/CUR pairs NCI-60 bioassay symmetrical and unsymmetrical analogs