ENPP1 in the Regulation of Mineralization and Beyond.
ENPP1 is well known for its role in regulating skeletal and soft tissue mineralization. It primarily exerts its function through the generation of pyrophosphate, a key inhibitor of hydroxyapatite formation. Several previous studies have suggested that ENPP1 also contributes to a range of human diseases including diabetes, cancer, cardiovascular disease, and osteoarthritis. In this review, we summarize the pathological roles of ENPP1 in mineralization and these soft tissue disorders. We also discuss the underlying mechanisms through which ENPP1 exerts its pathological effects. A fuller understanding of the pathways through which ENPP1 acts may help to develop novel therapeutic strategies for these commonly diagnosed morbidities.
['Roberts|Fiona|F|', 'Zhu|Dongxing|D|', 'Farquharson|Colin|C|', 'Macrae|Vicky E|VE|']
D000818:Animals D002318:Cardiovascular Diseases D003920:Diabetes Mellitus D006801:Humans D009369:Neoplasms D010003:Osteoarthritis D010727:Phosphoric Diester Hydrolases D011755:Pyrophosphatases
ENPP1 mineralization diabetes cardiovascular disease pathological effects