Aflatoxins ingestion and canine mammary tumors: There is an association?
The aim of this study was to determine the presence of mycotoxins on dogs feed and to explore the potential association between mycotoxins exposure and the chance of mamary tumors in a case-control study. The study included 256 female dogs from a hospital population, 85 with mammary tumors (case group) and 171 without mammary tumors (control group). An epidemiological questionnaire was applied to both groups, and the data were analyzed by the EpiInfo statistical package. For the study, 168 samples of the feed offered to dogs were analyzed for the presence of aflatoxins, fumonisins and zearalenone by high-performance liquid chromatography. Mycotoxins were found in 79 samples (100%) in the case group and 87/89 (97.8%) in the control group. Mycotoxins were detected in all types of feed, regardless feed quality. Level of aflatoxin B1 (p = 0.0356, OR = 2.74, 95%, CI 1.13 to 6.60), aflatoxin G1 (AFG1) (p = 0.00007, OR = 4.60, 95%, CI = 2.16 to 9.79), and aflatoxin G2 (AFG2) (p = 0.0133, OR = 9.91, 95%, CI 1.21 to 81.15) were statistically higher in case of mammary cancer. In contrast, neutering was a protective factor for mammary cancer (p = 0.0004, OR = 0.32, 95%, CI = 0.17 to 0.60).
['Frehse|M S|MS|', 'Martins|M I M|MI|', 'Ono|E Y S|EY|', 'Bracarense|A P F R L|AP|', 'Bissoqui|L Y|LY|', 'Teixeira|E M K|EM|', 'Santos|N J R|NJ|', 'Freire|R L|RL|']
D016604:Aflatoxin B1 D000348:Aflatoxins D000821:Animal Feed D000818:Animals D001938:Brazil D002274:Carcinogens, Environmental D016022:Case-Control Studies D004285:Dogs D005260:Female D005506:Food Contamination D037341:Fumonisins D006762:Hospitals, Animal D006784:Hospitals, Teaching D015674:Mammary Neoplasms, Animal D010052:Ovariectomy D015025:Zearalenone
Aflatoxin Dogs Fumonisin Zearalenone Mammary cancer Risk factors