Fluctuations in eGFR in relation to unenhanced and enhanced MRI and CT outpatients.
OBJECTIVE
To study fluctuations in estimated glomerular filtration rate (eGFR) in relation to contrast medium (CM) enhanced magnetic resonance imaging (MRI) and computed tomography (CT) compared to control groups in outpatients.


MATERIALS AND METHODS
eGFR was determined right before the imaging procedure and three days later at the department or at the patient's home. The iodine-based and gadolinium-based contrast media were the same as used for all other examinations at the department.


RESULTS
A total of 716 patients completed the study. There was a statistically significant, but not clinically relevant rise in eGFR after three days in all four groups. The average eGFR variation was 4.8 ml/min/1.73 m(2). There were large variations in eGFR between the two measurements in 45.8% of the patients as they had a change greater than ± 10 ml/min/1.73 m(2). Only three patients fulfilled the contrast-induced nephropathy (CIN) requirement when the definition s-creatinine ≥ 44 μmol/l (0.5mg/dl) was used.


CONCLUSIONS
eGFR in outpatients undergoing MRI or CT did vary independently of whether the patient received contrast or not. The findings probably reflect the natural variations in s-creatinine levels. This should be taken into consideration when CIN is studied.
['Azzouz|Manal|M|', 'Rømsing|Janne|J|', 'Thomsen|Henrik S|HS|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D000553:Ambulatory Care D016477:Artifacts D003287:Contrast Media D003718:Denmark D005260:Female D005919:Glomerular Filtration Rate D006801:Humans D015994:Incidence D007479:Iopamidol D007674:Kidney Diseases D008279:Magnetic Resonance Imaging D008297:Male D008536:Meglumine D008875:Middle Aged D009942:Organometallic Compounds D015203:Reproducibility of Results D018570:Risk Assessment D012680:Sensitivity and Specificity D014057:Tomography, X-Ray Computed D055815:Young Adult
Fluctuations eGFR Outpatients Gadolinium-based contrast media CIN Iodine-based contrast media