Waldenstrom macroglobulinemia with CD5+ expression presented as cryoglobulinemic glomerulonephropathy: a case report.
Waldenstrom macroglobulinemia (WM) is a B-cell lymphoproliferative disorder associated with bone marrow involvement of lymphoplasmacytic lymphoma (LPL) and an IgM monoclonal gammopathy. Generally B-lymphocytes in LPL do not express CD5 that is important for differential diagnosis of B-cell lymphoproliferative disorders. In WM, various renal diseases and type I cryoglobulinemia are well described separately, but cryoglobulinemic glomerulonephropathy is very rarely reported. A 61-yr-old woman complained of generalized edema, cyanosis of the extremities in cold weather, visual disturbance, and pancytopenia. Bone marrow and renal biopsy showed CD5+ expressing B-cells and cryoglobulinemic glomerulonephropathy. With the diagnosis of WM, she received cyclophosphamide, doxorubicin, vincristine and prednisolone chemotherapy and got complete remission. Here, we report a rare case of WM associated with unusual expression of CD5+ B-lymphocytes and cryoglobulinemic glomerulonephropathy, and emphasize the importance of the clinical features in differentiating CD5+ B-cell lymphoproliferative disorders.
['Kim|You Lim|YL|', 'Gong|Soo Jung|SJ|', 'Hwang|Young Hwan|YH|', 'Joo|Jong Eun|JE|', 'Cho|Young Uk|YU|', 'Lee|Jung Ae|JA|', 'Sung|Su Ah|SA|', 'Lee|So Young|SY|', 'Kim|Nae Yoo|NY|']
D000970:Antineoplastic Agents D001402:B-Lymphocytes D001853:Bone Marrow D018956:CD5 Antigens D003449:Cryoglobulinemia D003520:Cyclophosphamide D003937:Diagnosis, Differential D004317:Doxorubicin D004359:Drug Therapy, Combination D005260:Female D005921:Glomerulonephritis D006801:Humans D007668:Kidney D008875:Middle Aged D010265:Paraproteinemias D011239:Prednisolone D014750:Vincristine D008258:Waldenstrom Macroglobulinemia
Waldenstrom Macroglobulinemia CD5+ Lymphoplasmacytic Lymphoma Cryoglobulinemic Glomerulonephritis