Deoxynivalenol exposure assessment through a modelling approach of food intake and biomonitoring data - A contribution to the risk assessment of an enteropathogenic mycotoxin.
Deoxynivalenol (DON), an enteropathogenic mycotoxin produced by Fusarium species, is usually associated with adverse health outcomes such as gastrointestinal diseases and immunotoxicity. To estimate DON exposure of the Portuguese population at national level, a modelling approach, based on data from 94 Portuguese volunteers, was developed considering the inputs of the food consumption data generated within the National Food and Physical Activity Survey and the human biomonitoring data used to assess the exposure to DON. Ten models of association between DON urinary biomarkers and food items (pasta, cookies, biscuits, sweets, bread, rusks, nuts, oilseeds, beer, meat, milk) were established. Applying the most adequate model to the consumption data (n = 5811) of the general population, the exposure estimates of the Probable Daily Intake revealed that a fraction (0.1%) of the Portuguese population might exceed the Tolerable Daily Intake defined for DON. The analysis stratified by age revealed children (3.2%) and adolescents (6.0%) are more likely to exceed the Tolerable Daily Intake for DON. Although the unavoidable uncertainties, these results are important contributions to understand the exposure to this mycotoxin in Portugal, to assess the associated risk and the potential public health consequences.
['Martins|Carla|C|', 'Torres|Duarte|D|', 'Lopes|Carla|C|', 'Correia|Daniela|D|', 'Goios|Ana|A|', 'Assunção|Ricardo|R|', 'Alvito|Paula|P|', 'Vidal|Arnau|A|', 'De Boevre|Marthe|M|', 'De Saeger|Sarah|S|', 'Nunes|Carla|C|']
D000293:Adolescent D000079687:Biological Monitoring D002648:Child D004435:Eating D005506:Food Contamination D006801:Humans D009183:Mycotoxins D011174:Portugal D018570:Risk Assessment D014255:Trichothecenes
Modelling Mycotoxins Food consumption Urinary biomarkers Public health