Genetic epidemiology of tooth agenesis in Japan: a population- and family-based study.
Tooth agenesis is one of the most common congenital anomalies in humans. However, the etiology of tooth agenesis remains largely unclear, as well as evidence base useful for genetic counseling. Therefore, we estimated the prevalence and sibling recurrence risk, and investigated agenetic patterns systematically. Tooth agenesis was classified into two subtypes: hypodontia (one to five missing teeth) and oligodontia (six or more missing teeth). The prevalence of these two subtypes were 6.8% [95% confidence interval (CI): 6.1-7.7%] and 0.1% (95% CI: 0.04-0.3%), respectively, and sibling recurrence risk of these were 24.5% (95% CI: 13.8-38.3%) and 43.8% (95% CI: 26.4-62.3%), respectively. This result suggests that the severe phenotype, oligodontia, might be mostly transmitted in a dominant fashion. Using a simple statistical modeling approach, our data were found to be consistent with a bilateral symmetry model, meaning that there was equal probability of missing teeth from the right and left sides.
['Machida|J|J|', 'Nishiyama|T|T|', 'Kishino|H|H|', 'Yamaguchi|S|S|', 'Kimura|M|M|', 'Shibata|A|A|', 'Tatematsu|T|T|', 'Kamamoto|M|M|', 'Yamamoto|K|K|', 'Makino|S|S|', 'Miyachi|H|H|', 'Shimozato|K|K|', 'Tokita|Y|Y|']
D000293:Adolescent D000328:Adult D000848:Anodontia D002648:Child D003710:Demography D005260:Female D006801:Humans D007564:Japan D008297:Male D017720:Molecular Epidemiology D015995:Prevalence D014070:Tooth D055815:Young Adult
tooth agenesis prevalence sibling recurrence risk hypodontia oligodontia