Design and synthesis of zinc protoporphyrin IX-adamantane/cyclodextrin/cellulose nanocrystals complexes for anticancer photodynamic therapy.
Two protoporphyrin IX (PpIX) adamantane derivatives were synthesized and then metallated with zinc. The Zn-PpIX derivatives, exhibiting a high singlet oxygen quantum yield, were tested for their photodynamic activity against the HT-29 cell line. In order to enhance their water-solubility and their cellular bioavailability, these photosensitizers were encapsulated into the hydrophobic cavity of cyclodextrins (CD) previously attached to cellulose nanocrystals (CNCs) via electrostatic interactions. Under illumination, the encapsulated adamantanyl-porphyrins exerted an enhanced in vitro cytotoxicity, as compared with the corresponding free photosensitizers.
['Ndong Ntoutoume|Gautier M A|GMA|', 'Granet|Robert|R|', 'Mbakidi|Jean-Pierre|JP|', 'Constantin|Eléna|E|', 'Bretin|Ludovic|L|', 'Léger|David Y|DY|', 'Liagre|Bertrand|B|', 'Chaleix|Vincent|V|', 'Brégier|Frédérique|F|', 'Sol|Vincent|V|']
D000218:Adamantane D000970:Antineoplastic Agents D049109:Cell Proliferation D002470:Cell Survival D002482:Cellulose D003505:Cyclodextrins D004305:Dose-Response Relationship, Drug D015195:Drug Design D004354:Drug Screening Assays, Antitumor D019073:HT29 Cells D006801:Humans D015394:Molecular Structure D053758:Nanoparticles D010778:Photochemotherapy D017319:Photosensitizing Agents D011524:Protoporphyrins D013329:Structure-Activity Relationship
Cellulose nanocrystals Photodynamic therapy Colorectal cancer Nanoparticles Porphyrins