A significant proportion of patients with primary central nervous system lymphoma harbor clonal bone marrow B-cells.
Clonal bone marrow (BM) B-cell populations are a common finding in patients with suspected primary central nervous system lymphoma (PCNSL). To assess their clinical significance, benign monoclonal B-cell lymphocytosis (MBL) needs to be differentiated from concomitant BM involvement, since patients with secondary central nervous system lymphoma (SCNSL) generally require more intensive treatment directed also at the component outside the central nervous system (CNS). Here, we retrospectively analyzed BM samplings in 51 patients with suspected PCNSL. We found clonal B cell populations in 8 of 51 cases (16%) by flow cytometry. None of these eight cases had BM involvement by high-grade lymphoma. No lymphoma relapses outside the CNS were recorded. Together, our data points at a significant percentage of patients with suspected PCNSL harboring clonal BM B-cells, which in this patient group always represented benign MBL. Failure to differentiate these populations from systemic lymphoma involvement may result in overtreatment of patients.
['Brandt|Anna|A|0000-0002-3059-6146', 'Matschke|Jakob|J|', 'Fehrle|Wilfried|W|', 'von Wenserski|Lisa|L|', 'Bokemeyer|Carsten|C|', 'Illerhaus|Gerald|G|0000-0002-0009-8138', 'Binder|Mascha|M|']
D000328:Adult D000368:Aged D001402:B-Lymphocytes D015415:Biomarkers D001706:Biopsy D001853:Bone Marrow D016543:Central Nervous System Neoplasms D060965:Clonal Evolution D005260:Female D006801:Humans D016130:Immunophenotyping D016393:Lymphoma, B-Cell D008297:Male D008875:Middle Aged D060787:Neoplasm Grading D009367:Neoplasm Staging
Primary central nervous system lymphoma clonal bone marrow B-cells flow cytometry