Preoperative transcatheter arterial chemotherapy may suppress oxidative stress in hepatocellular carcinoma cells and reduce the risk of short-term relapse.
In this study, we aim to investigate oxidative stress in hepatocellular carcinoma (HCC) tissues in patients receiving preoperative transcatheter arterial chemotherapy (TAC) and its association with prognosis. A total of 89 HCC patients enrolled in this study, 39 received preoperative TAC 1 week before surgery (pTAC group) and 50 did not (non-pTAC group). All patients underwent hepatectomy and postoperative TAC and were followed up to 400 weeks. Samples of liver tissue without HCC and hepatitis (n = 15) served as normal controls. Cellular levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), TP53, and p21waf1/cip1 were measured in both cancer and surrounding tissues using an immunohistochemistry assay. Taken together, our data suggested that preoperative TAC might postpone postoperative HCC relapse within 1 year via suppression of tumor cells by induction of high levels of oxidative stress.
['Su|Hao|H|', 'Zhu|Guangzhi|G|', 'Djaja P|Ketut Indra|KI|', 'Lin|Yi|Y|', 'Gong|Yizhen|Y|', 'Liu|Xiaoguang|X|', 'Li|Jiaquan|J|', 'Liu|Zhiming|Z|', 'Qin|Xiao|X|', 'Li|Lequn|L|', 'Liu|Tangwei|T|', 'Lu|Zili|Z|', 'Wei|Minyi|M|', 'Yan|Lunan|L|', 'Winkler|Cheryl Ann|CA|', "O'Brien|Stephen J|SJ|", 'Li|Jing|J|', 'Xiao|Kaiyin|K|', 'Peng|Tao|T|']
transcatheter arterial chemotherapy oxidative stress hepatocellular carcinoma TP53 p21waf1/cip1