Biocompatible cellulose-based supramolecular nanoparticles driven by host-guest interactions for drug delivery.
To extend the applications of natural products in nanomedicine, novel cellulose-based supramolecular nanoparticles (SNPs) were fabricated via a host-guest driven self-assembly strategy here. The adamantane-grafted carboxyethyl hydroxyethyl cellulose and β-cyclodextrin-grafted glycerol ethoxylate were synthesized to self-assemble into the SNPs. Furthermore, doxorubicin (DOX)-functionalized β-cyclodextrin was encapsulated into SNPs via an in situ co-assembly process to generate DOX-loaded SNPs (DOX-SNPs). The SNPs exhibited a quasi-spherical morphology with an average diameter of ∼25 nm. The DOX-SNPs with relatively larger diameter possessed a high DOX loading efficiency (∼94 %) and the pH-responsive drug release behaviors, which made them suitable as a drug delivery system. In vitro cytotoxicity assays demonstrated the excellent cytocompatibility of SNPs and the efficient inhibition of Hela cell proliferation of DOX-SNPs. Moreover, the DOX-SNPs could effectively enter Hela cells via endocytosis and release DOX under endo/lysosome pH. Thus, this nanocarrier has promising translational potential in cancer therapy and personalized nanomedicine.
['Yang|Xuefeng|X|', 'Jiang|Xueyu|X|', 'Yang|Hongye|H|', 'Bian|Liming|L|', 'Chang|Chunyu|C|', 'Zhang|Lina|L|']
D000218:Adamantane D001672:Biocompatible Materials D049109:Cell Proliferation D002482:Cellulose D004317:Doxorubicin D004337:Drug Carriers D065546:Drug Liberation D005995:Glyceryl Ethers D006367:HeLa Cells D006801:Humans D050997:Nanomedicine D053758:Nanoparticles D047392:beta-Cyclodextrins
Biocompatibility Drug delivery 1-Adamantylamine (Ad-NH(2), PubChem CID: 2130) 2-Hydroxyethyl cellulose (HEC, PubChem CID: 24846132) Acrylamide (PubChem CID: 6579) Cellulose-based nanoparticles Cyclodextrin Doxorubicin hydrochloride (DOX·HCl, PubChem CID: 443939) Glycerol ethoxylate (GE, PubChem CID: 88802) Host–guest interactions Sodium azide (PubChem CID: 33557) Supramolecular nanocarriers Tetrabutylammonium hydroxide (TBA-OH, PubChem CID: 2723671) benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate (PyBOP, PubChem CID: 2724699) p-toluenesulfonyl chloride (TsCl, PubChem CID: 7397) β-cyclodextrin (CD, PubChem CID: 444041)