A cancer cell-specific fluorescent probe for imaging Cu2+ in living cancer cells.
Monitoring copper level in cancer cells is important for the further understanding of its roles in the cell proliferation, and also could afford novel copper-based strategy for the cancer therapy. Herein, we have developed a novel cancer cell-specific fluorescent probe for the detecting Cu2+ in living cancer cells. The probe employed biotin as the cancer cell-specific group. Before the treatment of Cu2+, the probe showed nearly no fluorescence. However, the probe can display strong fluorescence at 581nm in response to Cu2+. The probe exhibited excellent sensitivity and high selectivity for Cu2+ over the other relative species. Under the guidance of biotin group, could be successfully used for detecting Cu2+ in living cancer cells. We expect that this design strategy could be further applied for detection of the other important biomolecules in living cancer cells.
['Wang|Chao|C|', 'Dong|Baoli|B|', 'Kong|Xiuqi|X|', 'Song|Xuezhen|X|', 'Zhang|Nan|N|', 'Lin|Weiying|W|']
D000818:Animals D003300:Copper D003584:Cytological Techniques D005456:Fluorescent Dyes D006367:HeLa Cells D006801:Humans D051379:Mice D015335:Molecular Probes D041681:NIH 3T3 Cells D013050:Spectrometry, Fluorescence
Fluorescent probe Cancer cell Copper Fluorescence imaging