Neurovascular Coupling During Visual Stimulation in Multiple Sclerosis: A MEG-fMRI Study.
The process of neurovascular coupling ensures that increases in neuronal activity are fed by increases in cerebral blood flow. Evidence suggests that neurovascular coupling may be impaired in Multiple Sclerosis (MS) due to a combination of brain hypoperfusion, altered cerebrovascular reactivity and oxygen metabolism, and altered levels of vasoactive compounds. Here, we tested the hypothesis that neurovascular coupling is impaired in MS. We characterized neurovascular coupling as the relationship between changes in neuronal oscillatory power within the gamma frequency band (30-80 Hz), as measured by magnetoencephalography (MEG), and associated hemodynamic changes (blood oxygenation level dependent, BOLD, and cerebral blood flow, CBF) as measured by functional MRI. We characterized these responses in the visual cortex in 13 MS patients and in 10 matched healthy controls using a reversing checkerboard stimulus at five visual contrasts. There were no significant group differences in visual acuity, P100 latencies, occipital gray matter (GM) volumes and baseline CBF. However, in the MS patients we found a significant reduction in peak gamma power, BOLD and CBF responses. There were no significant differences in neurovascular coupling between groups, in the visual cortex. Our results suggest that neuronal and vascular responses are altered in MS. Gamma power reduction could be an indicator of GM dysfunction, possibly mediated by GABAergic changes. Altered hemodynamic responses confirm previous reports of a vascular dysfunction in MS. Despite altered neuronal and vascular responses, neurovascular coupling appears to be preserved in MS, at least within the range of damage and disability studied here.
['Stickland|Rachael|R|', 'Allen|Marek|M|', 'Magazzini|Lorenzo|L|', 'Singh|Krish D|KD|', 'Wise|Richard G|RG|', 'Tomassini|Valentina|V|']
D000328:Adult D001921:Brain D005071:Evoked Potentials D005260:Female D065818:Gamma Rhythm D066128:Gray Matter D006439:Hemodynamics D006801:Humans D008279:Magnetic Resonance Imaging D015225:Magnetoencephalography D008297:Male D064847:Multimodal Imaging D009103:Multiple Sclerosis D000069336:Neurovascular Coupling D009929:Organ Size D010100:Oxygen D010775:Photic Stimulation D014792:Visual Acuity D014796:Visual Perception
neurovascular coupling Multiple Sclerosis cerebral blood flow magnetoencephalography functional MRI visual function