Photoactivatable Platinum-Based Anticancer Drugs: Mode of Photoactivation and Mechanism of Action.
Platinum-based anticancer drugs are a class of widely used agents in clinical cancer treatment. However, their efficacy was greatly limited by their severe side effects and the arising drug resistance. The selective activation of inert platinum-based drugs in the tumor site by light irradiation is able to reduce side effects, and the novel mechanism of action of photoactivatable platinum drugs might also conquer the resistance. In this review, the recent advances in the design of photoactivatable platinum-based drugs were summarized. The complexes are classified according to their mode of action, including photoreduction, photo-uncaging, and photodissociation. The rationale of drug design, dark stability, photoactivation process, cytotoxicity, and mechanism of action of typical photoactivatable platinum drugs were reviewed. Finally, the challenges and opportunities for designing more potent photoactivatable platinum drugs were discussed.
['Dai|Ziwen|Z|', 'Wang|Zhigang|Z|0000-0003-1025-4664']
D000818:Animals D000970:Antineoplastic Agents D006801:Humans D008027:Light D009944:Organoplatinum Compounds D055668:Photochemical Processes D010984:Platinum D045663:Quantum Dots
anticancer photoactivatable platinum drugs photoactivate chemotherapy prodrugs