Impact of the Everolimus-eluting Bioresorbable Scaffold in Coronary Atherosclerosis.
INTRODUCTION AND OBJECTIVES
The Absorb bioresorbable vascular scaffold has been shown to decrease total plaque areas in the treated segment. However, it is unknown whether plaque size is modified in scaffolded segments only or whether the modification extends to other coronary segments.


METHODS
Absorb Cohort A is a single-arm, prospective study, with safety and imaging endpoints, in which 30 patients underwent percutaneous coronary intervention with the first generation Absorb bioresorbable vascular scaffold. Noninvasive multislice computed tomography imaging was performed in 18 patients at 18 months and 5 years of follow-up. The present study was an intrapatient comparison of matched segments (normalized by the segment length) of the scaffolded region with nonintervened segments for lumen volume, vessel volume, plaque volume, plaque burden, and percent change in plaque atheroma volume.


RESULTS
All 18 scaffolded segments could be analyzed. In the nonintervened segments, 1 of 72 segments had a motion artifact and was excluded. Serial comparison showed that the scaffolded segments showed no significant change in the mean plaque burden, total atheroma volume, total lumen volume, or vessel volume between 18 months and 5 years. Conversely, the untreated segments showed a significant increase in plaque burden (2.7 ± 6.5%; P < .01) and normalized plaque volumes (8.0 ± 22.8mm(3); P < .01). This resulted in a significant difference in plaque burden between scaffolded and nonintervened segments (P = .03).


CONCLUSIONS
In this small series, the Absorb bioresorbable vascular scaffold showed the potential to provide an additional benefit to pharmacological therapy in locally reducing progression of percent plaque burden. These findings need to be confirmed in larger studies.
['Campos|Carlos M|CM|', 'Garcia-Garcia|Hector M|HM|', 'Muramatsu|Takashi|T|', 'de Araujo Gonçalves|Pedro|P|', 'Onuma|Yoshinobu|Y|', 'Dudek|Dariusz|D|', 'Thuesen|Leif|L|', 'Webster|Mark W I|MW|', 'Kitslaar|Pieter|P|', 'Veldhof|Susan|S|', 'Reiber|Johan H C|JH|', 'Nieman|Koen|K|', 'Ormiston|John A|JA|', 'Serruys|Patrick W|PW|']
D020341:Absorbable Implants D000072226:Computed Tomography Angiography D003324:Coronary Artery Disease D023921:Coronary Stenosis D054855:Drug-Eluting Stents D000068338:Everolimus D005260:Female D006801:Humans D007166:Immunosuppressive Agents D008297:Male D008875:Middle Aged D061330:Multidetector Computed Tomography D011446:Prospective Studies D054457:Tissue Scaffolds D016896:Treatment Outcome
Atherosclerosis Absorb Angiografía coronaria con tomografía computarizada Aterosclerosis Computed tomography coronary angiography Coronary plaque Disease progression Placa coronaria Progresión de la enfermedad