The observational study of delayed wound healing after tooth extraction in patients receiving oral bisphosphonate therapy.
INTRODUCTION
In this study, we investigated whether such a discontinuation of oral bisphosphonate (BP) for 3 months might influence the incidence of BP-related osteonecrosis of the jaw (BRONJ) and wound healing after tooth extraction in patients receiving oral BP therapy.


MATERIAL AND METHODS
There were a total of 434 teeth in 201 patients (18 males and 183 females). The patients were divided into two groups depending on whether or not they underwent a 3-month discontinuation of BP therapy (BP- and BP+) before tooth extraction. In this observational study investigated delayed wound healing after tooth extraction in patients receiving oral BP therapy.


RESULTS
In all cases of the BP- group, there were no BRONJ although there was delayed wound healing in two cases. However, in one case of the BP+ group, oral BP was continued because it was deemed high risk to discontinue treatment by the patient's physician. In this case, an intraoral fistula was still present with bone exposure at 120 weeks after extraction (BRONJ stage 1).


CONCLUSION
This study supports the idea of a drug holiday and encourages further clinical research on this topic of tooth extraction in patients receiving oral BP therapy.
['Hasegawa|Takumi|T|', 'Ri|Shinshou|S|', 'Umeda|Masahiro|M|', 'Komatsubara|Hideki|H|', 'Kobayashi|Masaki|M|', 'Shigeta|Takashi|T|', 'Yoshitomi|Izumi|I|', 'Ikeda|Hisazumi|H|', 'Shibuya|Yasuyuki|Y|', 'Asahina|Izumi|I|', 'Komori|Takahide|T|']
D000284:Administration, Oral D000328:Adult D000368:Aged D000369:Aged, 80 and over D019386:Alendronate D019072:Antibiotic Prophylaxis D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw D050071:Bone Density Conservation Agents D003731:Dental Caries D004164:Diphosphonates D012968:Etidronic Acid D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D016155:Oral Fistula D010485:Periapical Periodontitis D010518:Periodontitis D000068296:Risedronic Acid D012307:Risk Factors D013997:Time Factors D014081:Tooth Extraction D014945:Wound Healing
Tooth extraction Oral bisphosphonate Bisphosphonate Bisphosphonate related osteonecrosis of jaw