A punch in the gut - Intestinal inflammation links environmental factors to neurodegeneration in Parkinson's disease.
Parkinson's disease (PD) is an etiologically heterogeneous disorder. Experimental, clinical and epidemiological data suggest that intestinal inflammation contributes to the pathogenesis of PD. This article reviews recent literature on gut microbiota and intestinal inflammation in PD. We propose that intestinal inflammation links environmental factors (e.g. an altered gut microbiota composition) to neurodegeneration in (genetically susceptible) PD patients. In addition, there is an epidemiological and genetic overlap between PD and inflammatory bowel disease. This overlap provides an opportunity to develop new treatment strategies for at least a subgroup of PD patients.
['Becker|Anouck|A|', 'Faßbender|Klaus|K|', 'Oertel|Wolfgang H|WH|', 'Unger|Marcus M|MM|']
D005759:Gastroenteritis D000069196:Gastrointestinal Microbiome D006801:Humans D015212:Inflammatory Bowel Diseases D010300:Parkinson Disease
Intestinal inflammation Parkinson's disease Inflammatory bowel disease Calprotectin Crohn's disease NOD2 Short chain fatty acids