Tissue accumulation and urinary excretion of Cr in chromium picolinate (CrPic)-supplemented lambs.
Chromium (Cr) concentrations in liver, kidney, spleen, heart, lymph node, skeletal muscle, bone, testis and urine of lambs were measured to trace the biodistribution and bioaccumulation of Cr after oral supplementation with chromium picolinate (CrPic). Twenty-four Santa Inês lambs were treated with four different concentrations of CrPic: placebo, 0.250, 0.375 and 0.500 mg of CrPic/animal/day for 84 days. The basal diet consisted of Panicum maximum cv Massai hay and concentrate. Cr concentrations were measured by ICP-MS measuring (52)Cr as collected mass. There was a positive linear relationship between dose administered and the accumulation of Cr in the heart, lungs and testis. Urinary excretion of Cr occurred in a time and dose-dependent manner, so the longer or more dietary Cr provided, the greater excretion of the element. As some non-carcass components (such as lungs or heart) are added to bone and visceral meal to feed animals, there is a risk of bioaccumulation and biomagnification due to Cr offered as CrPic in the diet.
['Dallago|Bruno Stéfano Lima|BS|', 'Lima|Bárbara Alcântara Ferreira|BA|', 'Braz|Shélida Vasconcelos|SV|', 'Mustafa|Vanessa da Silva|Vda S|', 'McManus|Concepta|C|', 'Paim|Tiago do Prado|Tdo P|', 'Campeche|Aline|A|', 'Gomes|Edgard Franco|EF|', 'Louvandini|Helder|H|']
D000818:Animals D002857:Chromium D019587:Dietary Supplements D008297:Male D009928:Organ Specificity D010848:Picolinic Acids D012044:Regression Analysis D012756:Sheep D014018:Tissue Distribution
Biodistribution Bioaccumulation Santa Inês ICP–MS Mineral supplement