ABCG2 expression and uric acid metabolism of the intestine in hyperuricemia model rat.
To elucidate roles of the intestine in uric acid (UA) metabolism, we examined ABCG2 expression, tissue UA content and xanthine oxidoreductase (XOR) activity in different intestinal segments. Male SD rats were assigned to control group or oxonic acid-induced hyperuricemia (HUA) group. In control rats, ABCG2 was present both in villi and crypts in each segment. Tissue UA content and XOR activity were relatively high in duodenum and jejunum. However, in HUA rats, tissue UA content was significantly elevated in the ileum, whereas it remained unaltered in other segments. Moreover, ABCG2 expression in the HUA group was upregulated both in the villi and crypts of the ileum. These data indicate that the ileum may play an important role in the extra-renal UA excretion.
['Morimoto|Chikayuki|C|', 'Tamura|Yoshifuru|Y|', 'Asakawa|Shinichiro|S|', 'Kuribayashi-Okuma|Emiko|E|', 'Nemoto|Yoshikazu|Y|', 'Li|Jinping|J|', 'Murase|Takayo|T|', 'Nakamura|Takashi|T|', 'Hosoyamada|Makoto|M|', 'Uchida|Shunya|S|', 'Shibata|Shigeru|S|']
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2 D000818:Animals D033461:Hyperuricemia D007422:Intestines D008297:Male D010094:Oxonic Acid D051381:Rats D017207:Rats, Sprague-Dawley D014527:Uric Acid D014968:Xanthine Dehydrogenase
ABCG2 Hyperuricemia xanthine oxidoreductase rat intestine villin