Fragmented Dosing of β-alanine Induces A Body Weight-Independent Pharmacokinetic Response.
Personalised dosing of performance-enhancing food supplements is a hot topic. β-alanine is currently dosed using a fixed dose; however, evidence suggests that this might favour light compared to heavy subjects. A weight-relative dose seems to reverse this problem. In the present study, a novel dosing strategy was tested. A fragmented dose, composed of a fixed fragment of 800 mg and a weight-relative fragment of 10 mg/kg body weight, was compared to a fixed dose of 1600 mg and a weight-relative dose of 20 mg/kg body weight in a cohort of 20 subjects with a body weight ranging 48-139 kg (79.9 ± 24.4 kg). The results show that, following a fragmented dose, the influence of body weight on the pharmacokinetic response (iAUC) over a 210 min period was absent (r = -0.168; p = 0.478), in contrast to the fixed or weight-relative dose. The pharmacokinetic response also seemed more homogenous (CV% = 26%) following a fragmented dose compared to the fixed (33%) and the weight-relative dose (31%). The primary advantage of the easy-to-calculate fragmented dosing strategy is that it does not systematically favour or impair a certain weight group. Thorough dosage studies are lacking in the current field of sports and food supplements, therefore similar considerations can be made towards other (ergogenic) food supplements.
['Stautemas|Jan|J|0000-0001-7473-9340', 'Van de Loock|Alexia|A|', 'Van der Stede|Thibaux|T|', 'Pringels|Lauren|L|', 'Derave|Wim|W|0000-0002-2225-5587']
D000328:Adult D001835:Body Weight D002336:Carnosine D019587:Dietary Supplements D004305:Dose-Response Relationship, Drug D005260:Female D006801:Humans D008297:Male D058573:Performance-Enhancing Substances D055815:Young Adult D015091:beta-Alanine
food supplement ergogenic beta-alanine carnosine personalised nutrition