Nationwide Trends in Acute and Chronic Pancreatitis Among Privately Insured Children and Non-Elderly Adults in the United States, 2007-2014.
BACKGROUND & AIMS
Epidemiologic analyses of acute pancreatitis (AP) and chronic pancreatitis (CP) provide insight into causes and strategies for prevention and affect allocation of resources to its study and treatment. We sought to determine current and accurate incidences of AP and CP, along with the prevalence of CP, in children and adults in the United States.


METHODS
We collected data from the Truven MarketScan Research Databases of commercial inpatient and outpatient insurance claims in the United States from 2007 through 2014 (patients 0-64 years old). We calculated the incidences of AP and CP and prevalence of CP based on International Classification of Diseases, 9th Revision diagnosis codes. Children were defined as 18 years or younger and adults as 19 to 64 years old.


RESULTS
The incidence of pediatric AP was stable from 2007 through 2014, remaining at 12.3/100,000 persons in 2014. Meanwhile, the incidence for adult AP decreased from 123.7/100,000 persons in 2007 to 111.2/100,000 persons in 2014. The incidence of CP decreased over time in children (2.2/100,000 persons in 2007 to 1.9/100,000 persons in 2014) and adults (31.7/100,000 persons in 2007 to 24.7/100,000 persons in 2014). The prevalences of pediatric and adult CP were 5.8/100,000 persons and 91.9/100,000 persons, respectively, in 2014. Incidences of AP and CP increased with age. We found little change in incidence during the first decade of life but linear increases starting in the second decade.


CONCLUSIONS
We performed a comprehensive epidemiologic analysis of privately insured, non-elderly adults and children with AP and CP in the United States. Changes in gallstone formation, smoking, and alcohol consumption, along with advances in pancreatitis management, may be responsible for the stabilization and even decrease in the incidences of AP and CP.
['Sellers|Zachary M|ZM|', 'MacIsaac|Donna|D|', 'Yu|Helen|H|', 'Dehghan|Melody|M|', 'Zhang|Ke-You|KY|', 'Bensen|Rachel|R|', 'Wong|Jessie J|JJ|', 'Kin|Cindy|C|', 'Park|K T|KT|']
D000293:Adolescent D000328:Adult D000553:Ambulatory Care D002648:Child D002675:Child, Preschool D015331:Cohort Studies D005260:Female D006760:Hospitalization D006801:Humans D015994:Incidence D007223:Infant D007231:Infant, Newborn D007348:Insurance, Health D008297:Male D008875:Middle Aged D010195:Pancreatitis D050500:Pancreatitis, Chronic D015995:Prevalence D017149:Private Sector D012307:Risk Factors D012737:Sex Factors D014481:United States D055815:Young Adult
Trends Epidemiology Inflammation Pancreas