Hemodynamic instability during anesthesia in an adolescent with Loeys-Dietz syndrome: a case report.
We present a case of a 12-year-old male with Loeys-Dietz syndrome (LDS), a rare life-threatening genetic disorder. Multiple manifestations of LDS were present, including easy bruising, aortic root dilatation, multiple areas of vessel tortuosity, and joint laxity. The patient's medications included a beta-blocker and an angiotensin II receptor antagonist for prophylaxis against further aortic root dilatation due to his LDS. He experienced intraoperative hemodynamic instability and became pulseless during an orthopedic procedure, which had to be abandoned. Anesthesia was reattempted 2 days after cessation of the patient's antihypertensive medications and was successful with only minor postoperative hypertension.
['Bunting|Alexandra C|AC|', 'Bould|M Dylan|MD|']
D000771:Anesthesia, Intravenous D000959:Antihypertensive Agents D002648:Child D006439:Hemodynamics D006801:Humans D007022:Hypotension D007431:Intraoperative Complications D055947:Loeys-Dietz Syndrome D008297:Male D019637:Orthopedic Procedures
anesthesia Loeys-Dietz syndrome angiotensin receptor antagonists/adverse effects familial thoracic aneurysm hypotension/drug effects hypotension/surgery