Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among methicillin-resistant Staphylococcus aureus strains isolated from burn patients.
The increasing resistance to macrolide, lincosamide, and streptogramin B agents among methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide problem for the health community. This study aimed to investigate the prevalence of ermA, ermB, ermC, and msrA in MRSA strains isolated from burn patients in Ahvaz, southwest of Iran. A total of 76 isolates of S. aureus were collected from January to May 2017 from Taleghani Burn Hospital in Ahvaz. Among 76 S. aureus strains collected, 60 (78.9%) isolates were MRSA. The antimicrobial susceptibility testing for MRSA showed extreme high resistance rate to clarithromycin (100%) and azithromycin (100%), followed by erythromycin (98.3%). The PCR assay revealed that the frequency rates of msrA, ermA, and ermC genes were 23 (38.3%), 28 (46.7%), and 22 (36.7%), respectively. In addition, none of the MRSA isolates had the ermB gene. Because of the high prevalence of macrolide and lincosamide resistance found in MRSA isolates from infections of burn patients in Ahvaz, southwest of Iran, it is recommended that local periodic survey be performed for controlling the dissemination of antimicrobial resistance.
['Khoshnood|Saeed|S|', 'Shahi|Fatemeh|F|', 'Jomehzadeh|Nabi|N|', 'Montazeri|Effat Abbasi|EA|', 'Saki|Morteza|M|', 'Mortazavi|Seyed Mojtaba|SM|', 'Maghsoumi-Norouzabad|Leila|L|']
D000900:Anti-Bacterial Agents D002056:Burns D024881:Drug Resistance, Bacterial D006801:Humans D007492:Iran D055231:Lincosamides D018942:Macrolides D055624:Methicillin-Resistant Staphylococcus aureus D008826:Microbial Sensitivity Tests D016133:Polymerase Chain Reaction D015995:Prevalence D013207:Staphylococcal Skin Infections D025381:Streptogramin B
genes MRSA Iran clindamycin