Biomarkers for the Diagnosis of Neonatal Sepsis.
Neonatal sepsis is a major cause of morbidity and mortality in neonates and is challenging to diagnose. Infants manifest nonspecific clinical signs in response to sepsis; these signs may be caused by noninfectious conditions. Time to antibiotics affects neonatal sepsis outcome, so clinicians need to identify and treat neonates with sepsis expeditiously. Clinicians use serum biomarkers to measure inflammation and infection and assess the infant's risk of sepsis. However, current biomarkers lack sufficient sensitivity or specificity to be consider useful diagnostic tools. Continued research to identify novel biomarkers as well as novel ways of measuring them is sorely needed.
['Cantey|Joseph B|JB|', 'Lee|John H|JH|']
D000900:Anti-Bacterial Agents D015415:Biomarkers D002097:C-Reactive Protein D006801:Humans D007223:Infant D007231:Infant, Newborn D000071074:Neonatal Sepsis D018805:Sepsis
Biomarker Neonate Sepsis C-reactive protein Complete blood count Procalcitonin