Mitochondrial quality control: from molecule to organelle.
Mitochondria are organelles central to myriad cellular processes. To maintain mitochondrial health, various processes co-operate at both the molecular and organelle level. At the molecular level, mitochondria can sense imbalances in their homeostasis and adapt to these by signaling to the nucleus. This mito-nuclear communication leads to the expression of nuclear stress response genes. Upon external stimuli, mitochondria can also alter their morphology accordingly, by inducing fission or fusion. In an extreme situation, mitochondria are degraded by mitophagy. Adequate function and regulation of these mitochondrial quality control pathways are crucial for cellular homeostasis. As we discuss, alterations in these processes have been linked to several pathologies including neurodegenerative diseases and cancer.
['Roca-Portoles|Alba|A|', 'Tait|Stephen W G|SWG|']
D000818:Animals D006801:Humans D008928:Mitochondria D063154:Mitochondrial Dynamics D063306:Mitophagy D009369:Neoplasms D019636:Neurodegenerative Diseases D011494:Protein Kinases D015398:Signal Transduction D044767:Ubiquitin-Protein Ligases
Mitophagy ISR Mitochondrial diseases Mitochondrial dysfunction Mitochondrial fission Mitochondrial fusion PINK1 Parkin UPRmt