Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes.
BACKGROUND
Oxidized low-density lipoproteins and scavenger receptors (SRs) play an important role in the formation and development of atherosclerotic plaques. However, little is known about their presence in epicardial adipose tissue (EAT). The objective of the study was to evaluate the mRNA expression of different SRs in EAT of patients with ischemic heart disease (IHD), stratifying by diabetes status and its association with clinical and biochemical variables.


METHODS
We analyzed the mRNA expression of SRs (LOX-1, MSR1, CXCL16, CD36 and CL-P1) and macrophage markers (CD68, CD11c and CD206) in EAT from 45 patients with IHD (23 with type 2 diabetes mellitus (T2DM) and 22 without T2DM) and 23 controls without IHD or T2DM.


RESULTS
LOX-1, CL-P1, CD68 and CD11c mRNA expression were significantly higher in diabetic patients with IHD when compared with those without T2DM and control patients. MSR1, CXCL16, CD36 and CD206 showed no significant differences. In IHD patients, LOX-1 (OR 2.9; 95% CI 1.6-6.7; P = 0.019) and CD68 mRNA expression (OR 1.7; 95% CI 0.98-4.5; P = 0.049) were identified as independent risk factors associated with T2DM. Glucose and glycated hemoglobin were also shown to be risk factors.


CONCLUSIONS
SRs mRNA expression is found in EAT. LOX-1 and CD68 and were higher in IHD patients with T2DM and were identified as a cardiovascular risk factor of T2DM. This study suggests the importance of EAT in coronary atherosclerosis among patients with T2DM.
['Santiago-Fernández|Concepción|C|', 'Pérez-Belmonte|Luis M|LM|', 'Millán-Gómez|Mercedes|M|', 'Moreno-Santos|Inmaculada|I|', 'Carrasco-Chinchilla|Fernando|F|', 'Ruiz-Salas|Amalio|A|', 'Morcillo-Hidalgo|Luis|L|', 'Melero|José M|JM|', 'Garrido-Sánchez|Lourdes|L|', 'Jiménez-Navarro|Manuel|M|']
D000273:Adipose Tissue D000368:Aged D016022:Case-Control Studies D002465:Cell Movement D003324:Coronary Artery Disease D003924:Diabetes Mellitus, Type 2 D058065:Diabetic Cardiomyopathies D005260:Female D006801:Humans D008077:Lipoproteins, LDL D008264:Macrophages D008297:Male D008875:Middle Aged D017202:Myocardial Ischemia D010496:Pericardium D051116:Receptors, Scavenger D015854:Up-Regulation
Scavenger receptors Epicardial adipose tissue Ischemic heart disease Oxidized low-density lipoprotein Diabetes mellitus