Economic Evaluations Comparing a Trial of Labor with an Elective Repeat Cesarean Delivery: A Systematic Review.
BACKGROUND
For women who have had a previous low transverse cesarean delivery, the decision to undergo a trial of labor after cesarean (TOLAC) or an elective repeat cesarean delivery (ERCD) has important clinical and economic ramifications.


OBJECTIVES
To evaluate the cost-effectiveness of the alternative choices of a TOLAC and an ERCD for women with low-risk, singleton gestation pregnancies.


METHODS
We searched EMBASE, MEDLINE, CINAHL, Cochrane Library, EconLit, and the Cost-Effectiveness Analysis Registry with no language, publication, or date restrictions up until October 2015. Studies were included if they were primary research, compared a TOLAC with an ERCD, and provided information on the relative cost of the alternatives. Abstracts and partial economic evaluations were excluded.


RESULTS
Of 310 studies initially reviewed, 7 studies were included in the systematic review. In the base-case analyses, 4 studies concluded that TOLAC was dominant over ERCD, 1 study found ERCD to be dominant, and 2 studies found that although TOLAC was more costly, it offered more benefits and was thus cost-effective from a population perspective when considering societal willingness to pay for better outcomes. In sensitivity analyses, cost-effectiveness was found to be dependent on a high likelihood of TOLAC success, low risk of uterine rupture, and low relative cost of TOLAC compared with ERCD.


CONCLUSIONS
For women who are likely to have a successful vaginal delivery, routine ERCD may result in excess morbidity and cost from a population perspective.
['Rogers|Anna Joy|AJ|', 'Rogers|Nathaniel G|NG|', 'Kilgore|Meredith L|ML|', 'Subramaniam|Akila|A|', 'Harper|Lorie M|LM|']
D017604:Cesarean Section, Repeat D003362:Cost-Benefit Analysis D005260:Female D006801:Humans D017059:Models, Econometric D011247:Pregnancy D015203:Reproducibility of Results D014219:Trial of Labor D016064:Vaginal Birth after Cesarean
economics trial of labor cesarean delivery cost effectiveness elective surgical procedures pregnancy complications probability quality-adjusted life-years utility vaginal birth after cesarean