Management of adverse effects/toxicity of ibrutinib.
Bruton tyrosine kinase signaling (BTK) is critical step for B-cell development and immunoglobulin synthesis. Ibrutinib is an orally bioavailable bruton tyrosine kinase inhibitor (BTKi) and forms an irreversible covalent bound to BTK at the Cysteine-481 residue. Ibrutinib has been approved by FDA for the treatment of mantle cell lymphoma, chronic lymphocytic leukemia, Waldenstrom's macroglobulinemia, marginal zone lymphoma and chronic graft-versus-host disease in allogeneic stem cell transplantation. Ibrutinib is generally well tolerated drug with rapid and durable responses but has some side events. The most common side effects are diarrhea, upper respiratory tract infection, bleeding, fatigue and cardiac side effects. These events are generally mild (grade I-II). However atrial fibrillation (AF) and bleeding are important and may be grade III or higher side effects require strict monitoring. Here side effects of ibrutinib have been summarized and important considerations in the management of these adverse events have been reviewed.
['Paydas|Semra|S|']
D000225:Adenine D000077329:Agammaglobulinaemia Tyrosine Kinase D001281:Atrial Fibrillation D064420:Drug-Related Side Effects and Adverse Reactions D006470:Hemorrhage D006801:Humans D015994:Incidence D007938:Leukemia D008223:Lymphoma D010880:Piperidines D047428:Protein Kinase Inhibitors D011720:Pyrazoles D011743:Pyrimidines
Adverse effect Ibrutinib Diarrhea Infection Atrial fibrillation Bruising Skin reactions