Long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery for epithelial ovarian cancer.
OBJECTIVE
The aim of this study was to investigate long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery (FSS) to verify the feasibility of the limited surgery for epithelial ovarian cancer (OvCa).


STUDY DESIGN
We performed a regional multicenter retrospective study from January 1986 and March 2020, using clinical data corrected under the central pathological review system. Patients with recurrent tumor after surgery for stage I epithelial OvCa, aged equal or younger than 45 years were included for this study. We evaluated effect of FSS regarding long-term post-recurrence survival with statistical adjustment of propensity score-based method.


RESULTS
With the Kaplan-Meier method, original and adjusted survival curves were estimated for recurrence-after survival of patients with (n = 14) and without FSS (n = 26). Median time to disease-specific death was 18.6 months. In both original and adjusted cohorts, there were no significant difference between the two groups (log rank test; P > 0.05). Hazard ratio of disease-specific death was 1.264 (95% confidence interval, 0.563-2.836; P = 0.570) in original and 1.354 (95% confidence interval, 0.702-2.611; P = 0.366) in adjusted population. This result indicated that patients with FSS was not associated with poorer prognosis for recurrence-after survival than those without. When comparing patients not receiving FSS, patients receiving FSS with recurrence at spared ovary followed not significantly different survival outcome as well as those with extra-ovarian recurrence.


CONCLUSION
There was no significant difference of long-term post-recurrence survival outcomes between patients of epithelial OvCa with and without FSS in young women of reproductive age.
['Shigeyama|Munehisa|M|', 'Yoshihara|Masato|M|', 'Kitami|Kazuhisa|K|', 'Mogi|Kazumasa|K|', 'Uno|Kaname|K|', 'Iyoshi|Shohei|S|', 'Tano|Sho|S|', 'Yoshikawa|Nobuhisa|N|', 'Kajiyama|Hiroaki|H|']
Epithelial ovarian cancer Recurrence Fertility preservation Longterm effects