Tooth Loss and Risk of Dementia in the Community: the Hisayama Study.
OBJECTIVES
To clarify the effect of tooth loss on development of all-cause dementia and its subtypes in an elderly Japanese population.


DESIGN
Prospective cohort study.


SETTING
The Hisayama Study, Japan.


PARTICIPANTS
Community-dwelling Japanese adults without dementia aged 60 and older (N = 1,566) were followed for 5 years (2007-2012).


MEASUREMENTS
Participants were classified into four categories according to baseline number of remaining teeth (≥20, 10-19, 1-9, 0). The risk estimates of the effect of tooth loss on the development of all-cause dementia, Alzheimer's disease (AD), and vascular dementia (VaD) were computed using a Cox proportional hazards model.


RESULTS
During follow-up, 180 (11.5%) subjects developed all-cause dementia; 127 (8.1%) had AD, and 42 (2.7%) had VaD. After adjusting for potential confounders, there was a tendency for the multivariable-adjusted hazard ratio of all-cause dementia to increase with decrease in number of remaining teeth (P for trend = .04). The risk of all-cause dementia was 1.62 times as great in subjects with 10 to 19 teeth, 1.81 times as great in those with one to nine teeth, and 1.63 times as great in those with no teeth as in those with 20 teeth or more. An inverse association was observed between number of remaining teeth and risk of AD (P for trend = .08), but no such association was observed with risk of VaD (P for trend = .20).


CONCLUSION
Tooth loss is associated with an increased risk of all-cause dementia and AD in the Japanese population.
['Takeuchi|Kenji|K|', 'Ohara|Tomoyuki|T|', 'Furuta|Michiko|M|', 'Takeshita|Toru|T|', 'Shibata|Yukie|Y|', 'Hata|Jun|J|', 'Yoshida|Daigo|D|', 'Yamashita|Yoshihisa|Y|', 'Ninomiya|Toshiharu|T|']
D000368:Aged D044466:Asians D003704:Dementia D005260:Female D006801:Humans D007564:Japan D008137:Longitudinal Studies D008297:Male D008875:Middle Aged D009483:Neuropsychological Tests D011446:Prospective Studies D012307:Risk Factors D016388:Tooth Loss
prospective cohort study Alzheimer's disease vascular dementia epidemiology oral health