Design and development of engineered receptors for cell and tissue engineering.
Advances in synthetic biology have provided genetic tools to reprogram cells to obtain desired cellular functions that include tools to enable the customization of cells to sense an extracellular signal and respond with a desired output. These include a variety of engineered receptors capable of transmembrane signaling that transmit information from outside of the cell to inside when specific ligands bind to them. Recent advances in synthetic receptor engineering have enabled the reprogramming of cell and tissue behavior, controlling cell fate decisions, and providing new vehicles for therapeutic delivery.
['Javdan|Shwan B|SB|', 'Deans|Tara L|TL|']
cell and tissue engineering Synthetic biology synthetic receptors receptor engineering