Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents.
Microbial resistance to antibiotics is a global concern. The World Health Organization (WHO) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. Without urgent and coordinated action, the world is moving toward a post-antibiotic era, in which normal infections or minor injuries may become fatal. In an effort to find new agents, we report the synthesis and antimicrobial activities of 40 novel 1,3-diphenyl pyrazole derivatives. These compounds have shown zones of growth inhibition up to 85mm against Acinetobacter baumannii. We tested the active compounds against this Gram-negative bacterium in minimum inhibitory concentration (MIC) tests and found activity with concentration as low as 4μg/mL.
['Allison|Devin|D|', 'Delancey|Evan|E|', 'Ramey|Hunter|H|', 'Williams|Conrad|C|', 'Alsharif|Zakeyah Ali|ZA|', 'Al-Khattabi|Hessa|H|', 'Ontko|Allyn|A|', 'Gilmore|David|D|', 'Alam|Mohammad A|MA|']
D040981:Acinetobacter baumannii D000890:Anti-Infective Agents D019817:Benzoic Acid D001665:Binding Sites D020134:Catalytic Domain D024901:Drug Resistance, Multiple, Bacterial D006090:Gram-Negative Bacteria D006094:Gram-Positive Bacteria D008826:Microbial Sensitivity Tests D062105:Molecular Docking Simulation D011720:Pyrazoles D013329:Structure-Activity Relationship
Antimicrobials Resistant Pyrazole Acinetobacter baumannii Antibacterial Hydrazone Methicillin-resistant Staphylococcus aureus (MRSA)