Calibrated automated thrombography for monitoring coagulation function in patients with intracerebral haemorrhage.
OBJECTIVE
To monitor coagulation function in patients with intracerebral haemorrhage (ICH) using calibrated automated thrombography.


METHODS
Patients admitted to hospital with ICH (confirmed within 18 h of symptom onset) were enrolled. Patient history and blood samples were obtained within 6 h of admission; further blood samples were collected on days 4, 8 and 15 (or on discharge between days 9-15: grouped with day 15 data). Blood samples were also collected from age- and sex-matched healthy controls. All samples underwent calibrated automated thrombography.


RESULTS
At admission, thrombin lag time and time to peak was longer, and endogenous thrombin potential and peak height were lower, in patients with ICH (n = 20) than in healthy controls (n = 29). Lag time in patients with ICH gradually decreased, but remained significantly longer than in controls until day 8. Time to peak also gradually decreased, but remained longer in patients than in controls by day 15. Endogenous thrombin potential and peak height gradually increased in patients, but remained lower than in controls on day 15.


CONCLUSIONS
Patients with ICH have poorer coagulation function than healthy individuals, but this function gradually recovers during hospitalization.
['Yu|Yao|Y|', 'Wu|Jun|J|', 'Zhao|Wei|W|', 'Zhao|Lei|L|', 'Zhu|Chunpeng|C|', 'Gao|Xuguang|X|']
D001777:Blood Coagulation D002543:Cerebral Hemorrhage D004487:Edema D001330:Electronic Data Processing D015942:Factor VIIa D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D010314:Partial Thromboplastin Time D011516:Prothrombin D011517:Prothrombin Time D011994:Recombinant Proteins D013916:Thrombelastography D013917:Thrombin D013918:Thrombin Time
Intracerebral haemorrhage thrombin calibrated automated thrombogram