In Vivo Gold Complex Catalysis within Live Mice.
Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin-AuIII complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.
['Tsubokura|Kazuki|K|', 'Vong|Kenward K H|KK|', 'Pradipta|Ambara R|AR|', 'Ogura|Akihiro|A|', 'Urano|Sayaka|S|', 'Tahara|Tsuyoshi|T|', 'Nozaki|Satoshi|S|', 'Onoe|Hirotaka|H|', 'Nakao|Yoichi|Y|', 'Sibgatullina|Regina|R|', 'Kurbangalieva|Almira|A|', 'Watanabe|Yasuyoshi|Y|', 'Tanaka|Katsunori|K|']
D000818:Animals D002384:Catalysis D056831:Coordination Complexes D005456:Fluorescent Dyes D017127:Glycation End Products, Advanced D006046:Gold D051379:Mice D008807:Mice, Inbred BALB C D008819:Mice, Nude D061848:Optical Imaging D012709:Serum Albumin D014018:Tissue Distribution
amide bond formation fluorescent labeling glycoalbumin gold catalysis