Polymicrobial Staphylococcus aureus bacteremia: Frequency, distinguishing characteristics and outcome.
Staphylococcus aureus bacteremia (SAB) is usually monomicrobial (M-SAB). We reviewed SAB in adults (≥18years old) over a 13year-period and compared polymicrobial (P-SAB) and M-SAB. We encountered 93 P-SAB among 1537 SAB cases (6.1%). The source distribution was comparable; however, source-specified differences were apparent. P-SAB was noted in 12/58 (20.7%) necrotizing soft tissue infections/sacral decubiti and foot gangrene vs. 1/122 (0.8%) cellulitis/abscesses (P<0.001), in 7/64 (10.9%) femoral intravascular catheters (IVC) vs.16/376 (4.3%) IVC in other sites (P=0.03) and 15/134 (11.2%) healthcare-associated pneumonia (HAP) vs. 1/33 (3.0%) community-associated cases (P=0.1). Methicillin-resistance frequency was similar but community-associated SCCmec types (IV/V) were infrequent (17.9% vs. 34.2%; P=0.04). P-SAB was associated with higher mortality (50.5% vs. 24.2%; P<0.001) across nearly all sources. In summary, P-SAB is infrequent, usually encountered in necrotizing soft tissue infections/decubiti, femoral IVC and possibly HAP. The actual incidence of S. aureus in these infections should be defined.
['Khatib|Riad|R|', 'Sharma|Mamta|M|', 'Johnson|Leonard B|LB|', 'Riederer|Kathleen|K|', 'Briski|Laurence|L|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D016470:Bacteremia D060085:Coinfection D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D015995:Prevalence D012307:Risk Factors D013211:Staphylococcus aureus D016019:Survival Analysis D016896:Treatment Outcome D055815:Young Adult
Polymicrobial Staphylococcus aureus Bacteremia