Impact of intranasal application of nerve growth factor on the olfactory epithelium in rats with chemically induced diabetes.
Recent studies suggest that nerve growth factor (NGF) protects olfactory cells and axons from injury in vitro. Eighteen Wistar-Albino rats randomly divided into three groups: control group, diabetic group without NGF, and diabetic with NGF. Intranasal NGF (6 µg/day) was administered over a 5-day period. At the end of 30 days, the olfactory epithelium (OE) of NGF-applied diabetic rats regenerated, the epithelium thickness was significantly higher, and caspase-3 expression was not significantly different from the control. The current results demonstrate that intranasally administered NGF significantly reversed OE morphological changes in diabetes by decreasing diabetes-related cell death and inflammation.
['Yalim|Sidika|S|', 'Dağlıoğlu|Kenan|K|', 'Coskun|Gülfidan|G|', 'Polat|Sait|S|']
D000281:Administration, Intranasal D000818:Animals D048909:Diabetes Complications D003921:Diabetes Mellitus, Experimental D046529:Microscopy, Electron, Transmission D020932:Nerve Growth Factor D009831:Olfactory Mucosa D051381:Rats D017208:Rats, Wistar
nerve growth factor rat Diabetes mellitus