The role of the NADPH oxidase derived brain oxidative stress in the cocaine-related death associated with excited delirium: A literature review.
Excited delirium syndrome (ExDS) is a term used to describe a clinical condition characterized by bizarre and aggressive behaviour, commonly associated with the use of psychoactive compounds, especially cocaine. The pathophysiology of ExDS is complex and not yet fully understood. In addition to a central dopamine hypothesis, other mechanisms are thought to be involved in cocaine-related ExDS, such as increased reactive oxygen species production by the family of the NADPH oxidase NOX enzymes. In this review, we will summarize current knowledge on the crucial contribution of brain NADPH oxidase derived oxidative stress in the development of cocaine-induced ExDS. Data from animal models as well as human evidence will be discussed.
['Schiavone|Stefania|S|', 'Neri|Margherita|M|', 'Mhillaj|Emanuela|E|', 'Pomara|Cristoforo|C|', 'Trabace|Luigia|L|', 'Turillazzi|Emanuela|E|']
D000818:Animals D001921:Brain D003042:Cocaine D003693:Delirium D018765:Dopamine Uptake Inhibitors D006801:Humans D008959:Models, Neurological D019255:NADPH Oxidases D009419:Nerve Tissue Proteins D009474:Neurons D020258:Neurotoxicity Syndromes D018384:Oxidative Stress D011619:Psychotropic Drugs D017382:Reactive Oxygen Species
NADPH oxidase Brain Oxidative stress Excited delirium Cocaine