Level of FABP3, FABP4, Nt-proBNP and Total Cardiovascular Risk in the Population of Central Kazakhstan.
AIM
The study analyzed the level of cytokines playing the significant role in the diagnosis of circulatory system diseases and total cardiovascular risk.


MATERIAL AND METHODS
The study involved 1,244 residents of Karaganda region. We had studied baseline participant characteristics, in addition to calculating the total cardiovascular risk and assessment of Fatty Acid Binding Proteins 3 (FABP3), Fatty Acid Binding Proteins 4 (FABP4) and N-Terminal Prohormone of Brain Natriuretic Peptide (NT-proBNP) level.


RESULTS
The results showed the combination of high cardiovascular risk (CVR) with increased titers of cardiac markers, reflecting common pathogenic mechanisms in its development, among residents of Karaganda region.


CONCLUSION
The combination of high CVR with the increased titers of cardiac markers showed common pathogenic mechanisms in its development, and support the diagnostic and prognostic value of these parameters among residents of Karaganda region, and also reflects the possibility to include these cardiac markers in the program of screening survey of population for early prevention of cardiovascular disease and its complications.
['Marchenko|Alexandr Borisovich|AB|', 'Nildibayeva|Farida Ustarovna|FU|', 'Sorokina|Marina Anatolevna|MA|', 'Laryushina|Elena Mihaylovna|EM|', 'Turgunova|Lyudmila Gennadevna|LG|', 'Turmukhambetova|Anar Akyilbekovna|AA|']
total cardiovascular risk Central Kazakhstan cardiac markers epidemiology pathogenesis