Cancer killers in the human gut microbiota: diverse phylogeny and broad spectra.
Cancer as a large group of complex diseases is believed to result from the interactions of numerous genetic and environmental factors but may develop in people without any known genetic or environmental risks, suggesting the existence of other powerful factors to influence the carcinogenesis process. Much attention has been focused recently on particular members of the intestinal microbiota for their potential roles in promoting carcinogenesis. Here we report the identification and characterization of intestinal bacteria that exhibited potent anti-malignancy activities on a broad range of solid cancers and leukemia. We collected fecal specimens from healthy individuals of different age groups (preschool children and university students), inspected their effects on cancer cells, and obtained bacteria with potent anti-malignancy activities. The bacteria mostly belonged to Actinobacteria but also included lineages of other phyla such as Proteobacteria and Firmicutes. In animal cancer models, sterile culture supernatant from the bacteria highly effectively inhibited tumor growth. Remarkably, intra-tumor administration of the bacterial products prevented metastasis and even cleared cancer cells at remote locations from the tumor site. This work demonstrates the prevalent existence of potent malignancy-killers in the human intestinal microbiota, which may routinely clear malignant cells from the body before they form cancers.
['Zhou|Yu-Jie|YJ|', 'Zhao|Dan-Dan|DD|', 'Liu|Huidi|H|', 'Chen|Hao-Ting|HT|', 'Li|Jia-Jing|JJ|', 'Mu|Xiao-Qin|XQ|', 'Liu|Zheng|Z|', 'Li|Xia|X|', 'Tang|Le|L|', 'Zhao|Zhan-Yi|ZY|', 'Wu|Ji-Heng|JH|', 'Cai|Yu-Xuan|YX|', 'Huang|Ya-Zhuo|YZ|', 'Wang|Peng-Ge|PG|', 'Jia|Yi-Yue|YY|', 'Liang|Pei-Qiang|PQ|', 'Peng|Xue|X|', 'Chen|Si-Yu|SY|', 'Yue|Zhi-Lin|ZL|', 'Yuan|Xin-Yuan|XY|', 'Lu|Tammy|T|', 'Yao|Bing-Qing|BQ|', 'Li|Yong-Guo|YG|', 'Liu|Gui-Rong|GR|', 'Liu|Shu-Lin|SL|']
D000293:Adolescent D000328:Adult D000818:Animals D001419:Bacteria D018407:Bacterial Physiological Phenomena D002470:Cell Survival D002648:Child D002675:Child, Preschool D004195:Disease Models, Animal D005243:Feces D005260:Female D008401:Gas Chromatography-Mass Spectrometry D000069196:Gastrointestinal Microbiome D006367:HeLa Cells D006801:Humans D008297:Male D054892:Metagenome D056186:Metagenomics D051379:Mice D009369:Neoplasms D010802:Phylogeny D012336:RNA, Ribosomal, 16S D055815:Young Adult
cancer gut microbiota leukemia Actinobacteria malignancy killer