The skin aging exposome.
The term "exposome" describes the totality of exposures to which an individual is subjected from conception to death. It includes both external and internal factors as well as the human body's response to these factors. Current exposome research aims to understand the effects all factors have on specific organs, yet today, the exposome of human skin has not received major attention and a corresponding definition is lacking. This review was compiled with the collaboration of European scientists, specialized in either environmental medicine or skin biology. A comprehensive review of the existing literature was performed using PubMed. The search was restricted to exposome factors and skin aging. Key review papers and all relevant, epidemiological, in vitro, ex vivo and clinical studies were analyzed to determine the key elements of the exposome influencing skin aging. Here we propose a definition of the skin aging exposome. It is based on a summary of the existing scientific evidence for the role of exposome factors in skin aging. We also identify future research needs which concern knowledge about the interaction of distinct exposomal factors with each other and the resulting net effects on skin aging and suggest some protective measures.
['Krutmann|Jean|J|', 'Bouloc|Anne|A|', 'Sore|Gabrielle|G|', 'Bernard|Bruno A|BA|', 'Passeron|Thierry|T|']
D003358:Cosmetics D004032:Diet D004781:Environmental Exposure D006358:Hot Temperature D006801:Humans D012307:Risk Factors D015595:Skin Aging D012892:Sleep Deprivation D012907:Smoking D013315:Stress, Psychological D057170:Translational Research, Biomedical
Air pollution Cosmetic strategies Infrared radiation Nutrition Ultraviolet radiation Visible light