Positive feedback loop SP1/MIR17HG/miR-130a-3p promotes osteosarcoma proliferation and cisplatin resistance.
Long noncoding RNAs (lncRNAs) have been identified to be critical regulator in the osteosarcoma (OS) tumorigenesis. However, the role of lncRNA MIR17HG in the OS proliferation and chemotherapy resistance is still unclear. Here, this research aims to investigate the function of lncRNA MIR17HG in the OS proliferation and cisplatin resistance. Clinically, results revealed that higher MIR17HG expression was associated with shorter overall survival. Functional investigations indicated that MIR17HG promoted the proliferation, invasion and cisplatin resistance of OS cells in vitro, and the MIR17HG knockdown inhibited the growth in vivo. Mechanistically, MIR17HG targeted the miR-130a-3p/SP1 axis, moreover, transcription factor SP1 bind with the MIR17HG promoter region to promote its expression. Taken together, MIR17HG displays the tumor-promotive role in the progression of OS through SP1/MIR17HG/miR-130a-3p/SP1 feedback loop. Our findings might help us to offer novel therapeutic strategies for OS.
['Meng|Yibin|Y|', 'Hao|Dingjun|D|', 'Huang|Yunfei|Y|', 'Jia|Shuaijun|S|', 'Zhang|Jianan|J|', 'He|Xirui|X|', 'Sun|Liang|L|', 'Liu|Deyin|D|']
D000818:Animals D000970:Antineoplastic Agents D001859:Bone Neoplasms D045744:Cell Line, Tumor D049109:Cell Proliferation D002945:Cisplatin D019008:Drug Resistance, Neoplasm D005260:Female D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008297:Male D008807:Mice, Inbred BALB C D008819:Mice, Nude D035683:MicroRNAs D012516:Osteosarcoma D062085:RNA, Long Noncoding D016329:Sp1 Transcription Factor
SP1 MIR17HG miR-130a-3p Osteosarcoma Cisplatin resistance