Characteristics of pediatric invasive pneumococcal diseases and the pneumococcal isolates in Suzhou, China before introduction of PCV13.
BACKGROUND
Data on characteristics of invasive pneumococcal diseases (IPD) is limited in China. We aimed to understand the clinical features and explore the molecular characteristics of the pneumococcal isolates in China.


METHODS
Since 2010, we prospectively collected the pneumococcal isolates and the IPD patients' demographic and clinical information in Suzhou University Affiliated Children's Hospital (SCH). The antibiotic susceptibility, serotypes, genotypes of Streptococcus pneumoniae strains were identified by E-test, quellung reaction and/or multiplex PCR, and multi-locus sequence typing, respectively.


RESULTS
During the period from January 2010 to December 2015, a total of 80 IPD patients were identified. They were diagnosed as meningitis (31.3%), septicemia (27.5%), pneumonia (21.3%) and others (20.0%). About half of them required vancomycin treatment, 42.5% were admitted to ICUs, 36.2% had complications and 6.2% were hospitalized for over 1year. The most common serotypes of the pneumococcal isolates were serotypes 6B and 14, the coverage of PCV13 was 92.5%, and CC236s and CC199s were the most common clone complexes.


CONCLUSIONS
Pediatric IPD patients had severe clinical symptoms, demanded intensive treatment, suffered poor prognosis and substantial burden. The pneumococcal isolates' serotype coverage of PCV13 vaccine was high, which leads to implication of PCV vaccine usage among children in China.
['Zhang|Xiyan|X|', 'Tian|Jianmei|J|', 'Shan|Wei|W|', 'Xue|Jian|J|', 'Tao|Yunzhen|Y|', 'Geng|Qian|Q|', 'Ding|Yunfang|Y|', 'Zhao|Genming|G|', 'Zhang|Tao|T|']
D000293:Adolescent D002648:Child D002675:Child, Preschool D002681:China D052978:Disk Diffusion Antimicrobial Tests D005260:Female D005838:Genotype D006801:Humans D007223:Infant D007231:Infant, Newborn D008297:Male D060885:Multiplex Polymerase Chain Reaction D011008:Pneumococcal Infections D011446:Prospective Studies D065288:Serogroup D012703:Serotyping D013296:Streptococcus pneumoniae
Invasive pneumococcal disease Suzhou Children Streptococcus pneumoniae