Does SARS-CoV-2 infection cause chronic neurological complications?
The current pandemic caused by severe acute respiratory syndrome coronavirus (SARS-CoV)-2 has created an unparalleled health crisis. Besides the acute respiratory infection, CoVs are neuroinvasive causing additional inflammation and neurodegeneration. This is likely also true of SARS-CoV-2 given reports of neurological manifestations in coronavirus disease 2019 (COVID-19) positive patients. Older adults > 65 years of age constitute a high-risk group prone to severe infection and death. Despite the higher mortality rate, a majority of cases are expected to recover and survive from this viral outbreak. But, the long-term consequences of SARS-CoV-2 neuroinfection are unknown. We discuss these potential chronic changes to the central nervous system (CNS) in relation to accelerated brain aging and age-related neurodegenerative disorders.
['Hascup|Erin R|ER|https://orcid.org/0000-0003-1037-0809', 'Hascup|Kevin N|KN|https://orcid.org/0000-0001-6604-1874']
D000073640:Betacoronavirus D000086382:COVID-19 D002908:Chronic Disease D018352:Coronavirus Infections D006801:Humans D009422:Nervous System Diseases D058873:Pandemics D011024:Pneumonia, Viral D000086402:SARS-CoV-2
Neurodegeneration COVID-19 Aging Alzheimer’s disease Cellular senescence Neurotropism