A phase I study of the effect of repeated oral doses of pantoprazole on the pharmacokinetics of a single dose of fedratinib in healthy male subjects.
PURPOSE
Fedratinib, an oral, selective Janus kinase 2 inhibitor with activity against both wild-type and mutant Janus kinase 2, has pH-dependent solubility, with free solubility at pH 1. Concomitant administration of drugs that reduce gastric acid secretion, such as pantoprazole, may decrease the absorption of fedratinib and affect patient outcomes. The aim of this study was to evaluate the impact of 7-day repeated 40-mg doses of pantoprazole on the pharmacokinetic (PK) properties of a single 500-mg dose of fedratinib in healthy male subjects.


METHODS
In this phase I, single-center, open-label, two-period, two-treatment, fixed-sequence crossover study, healthy male subjects were administered a single dose of fedratinib 500 mg on day 1 in Period 1, followed by pantoprazole 40 mg daily for 7 days (day 1 to day 7) and a single dose of fedratinib 500 mg on day 7 in Period 2. After the discontinuation of nine subjects due to vomiting, the protocol was amended to provide ondansetron as antiemetic prophylaxis to an additional ten enrolled subjects.


RESULTS
Twenty-six subjects were included. Repeated doses of pantoprazole 40 mg resulted in clinically insignificant increases in fedratinib exposure. Maximum plasma concentration increased by 1.09-fold and area under the plasma concentration-time curve from time 0 to infinity increased by 1.15-fold. All treatment-emergent adverse events were mild or moderate, except for one instance of neutropenia, which was considered unrelated to study intervention.


CONCLUSION
Coadministration with pantoprazole did not have clinically meaningful effects on fedratinib PK. No new or unexpected safety signals were observed with fedratinib.
['Ogasawara|Ken|K|', 'Vince|Bradley|B|', 'Xu|Christine|C|', 'Zhang|Meng|M|', 'Palmisano|Maria|M|', 'Krishna|Gopal|G|']
D000328:Adult D001682:Biological Availability D018592:Cross-Over Studies D004347:Drug Interactions D016903:Drug Monitoring D004359:Drug Therapy, Combination D004791:Enzyme Inhibitors D064368:Healthy Volunteers D006801:Humans D053614:Janus Kinase 2 D008297:Male D000077402:Pantoprazole D054328:Proton Pump Inhibitors D011759:Pyrrolidines D013449:Sulfonamides D016896:Treatment Outcome
Pantoprazole Pharmacokinetics Fedratinib Bioavailability Healthy subjects Proton pump inhibitors