Long-term renal outcomes in a cohort of 1814 Chinese patients with biopsy-proven lupus nephritis.
In the present study, we observed the renal outcomes in a cohort of 1814 Chinese patients with biopsy-proven lupus nephritis (LN) and evaluated the risk factors associated with poor renal prognosis. The 5 -, 10 -, 15 - and 20-year renal survival rates were 93.1%, 87.9%, 81.0% and 68.3%, respectively. Gender, LN duration, mean arterial pressure (MAP), proteinuria, serum creatinine, haemoglobin and pathological classification at the time of biopsy were independent risk factors for end-stage renal disease (ESRD). The long-term renal outcomes of patients with class II LN were unfavorable as opposed to those with class V. Additionally, the time-average proteinuria (TA-Pro) and the time-average mean arterial pressure (TA-MAP) during the follow-up were important risk factors for ESRD, with better predictive values than the baseline proteinuria and MAP. The results underscore the need for proteinuria and blood pressure control during follow-up in patients with LN; proteinuria levels should be controlled at least to < 1.0 g/24 h, and optimally to < 0.5 g/24 h; MAP should not exceed 96.5 mmHg. More attention should be paid to class II LN and emphasis should be placed on recurrence prevention of class II LN.
['Yang|J|J|', 'Liang|D|D|', 'Zhang|H|H|', 'Liu|Z|Z|', 'Le|W|W|', 'Zhou|M|M|', 'Hu|W|W|', 'Zeng|C|C|', 'Liu|Z|Z|']
D000293:Adolescent D000328:Adult D062186:Arterial Pressure D001706:Biopsy D001794:Blood Pressure D002681:China D003404:Creatinine D005260:Female D006454:Hemoglobins D006801:Humans D008181:Lupus Nephritis D008297:Male D011237:Predictive Value of Tests D011379:Prognosis D011507:Proteinuria D012307:Risk Factors D015996:Survival Rate D055815:Young Adult
renal outcome Lupus nephritis risk factor time-average proteinuria time-average mean arterial pressure