Perisylvian GABA levels in schizophrenia and bipolar disorder.
The aim of this study is to measure GABA levels of perisylvian cortices in schizophrenia and bipolar disorder patients, using proton magnetic resonance spectroscopy (1H-MRS). Patients with schizophrenia (n=25), bipolar I disorder (BD-I; n=28) and bipolar II disorder (BD-II; n=20) were compared with healthy controls (n=30). 1H-MRS data was acquired using a Siemens 3T whole body scanner to quantify right and left perisylvian structures' (including superior temporal lobes) GABA levels. Right perisylvian GABA values differed significantly between groups [χ2=9.62, df: 3, p=0.022]. GABA levels were significantly higher in the schizophrenia group compared with the healthy control group (p=0.002). Furthermore, Chlorpromazine equivalent doses of antipsychotics correlated with right hemisphere GABA levels (r2=0.68, p=0.006, n=33). GABA levels are elevated in the right hemisphere in patients with schizophrenia in comparison to bipolar disorder and healthy controls. The balance between excitatory and inhibitory controls over the cortical circuits may have direct relationship with GABAergic functions in auditory cortices. In addition, GABA levels may be altered by brain regions of interest, psychotropic medications, and clinical stage in schizophrenia and bipolar disorder.
['Atagün|Murat İlhan|Mİ|', 'Şıkoğlu|Elif Muazzez|EM|', 'Soykan|Çağlar|Ç|', 'Serdar Süleyman|Can|C|', 'Ulusoy-Kaymak|Semra|S|', 'Çayköylü|Ali|A|', 'Algın|Oktay|O|', 'Phillips|Mary Louise|ML|', 'Öngür|Dost|D|', 'Moore|Constance Mary|CM|']
D000328:Adult D014150:Antipsychotic Agents D001303:Auditory Cortex D001714:Bipolar Disorder D005260:Female D006801:Humans D009682:Magnetic Resonance Spectroscopy D008297:Male D008875:Middle Aged D066244:Proton Magnetic Resonance Spectroscopy D012559:Schizophrenia D013702:Temporal Lobe D055815:Young Adult D005680:gamma-Aminobutyric Acid
GABA Schizophrenia Bipolar disorder Magnetic resonance spectroscopy Auditory cortex