Assessing the Relationship between Helicobacter pylori and Chronic Kidney Disease.
The relationship between Helicobacter pylori infection and/or gastric disorders and chronic kidney disease (CKD) has not been elucidated. We investigated the relationship between Helicobacter pylori and/or atrophic gastritis (AG) and chronic kidney disease. In total, 3560 participants (1127 men and 2433 women) were eligible for this cross-sectional study. We divided participants into four study groups: with/without Helicobacter pylori infection and with/without AG. The HP (+) AG (-) group demonstrated a significant association with CKD compared with the HP (-) AG (-) group (adjusted odds ratio, 1.443; 95% confidence interval, 1.047-1.989). In contrast, the HP (+) AG (+) group showed significantly lower adjusted odds of CKD than the HP (-) AG (-) group (adjusted odds ratio, 0.608; 95% confidence interval, 0.402-0.920). H. pylori infection without AG might be associated with CKD in these participants. Conversely, the HP (+) AG (+) group had lower odds of CKD. Uncovering an association between gastric and renal conditions could lead to development of new treatment strategies.
['Hata|Koichi|K|', 'Koyama|Teruhide|T|0000-0002-8161-368X', 'Ozaki|Etsuko|E|', 'Kuriyama|Nagato|N|', 'Mizuno|Shigeto|S|', 'Matsui|Daisuke|D|', 'Watanabe|Isao|I|', 'Uehara|Ritei|R|', 'Watanabe|Yoshiyuki|Y|']
Helicobacter pylori chronic kidney disease atrophic gastritis inter-organ interactions