Polyclonal antibody targeting SOX11 cannot differentiate mantle cell lymphoma from B-cell non-Hodgkin lymphomas.
OBJECTIVES
To determine whether SOX11 is a diagnostic marker of mantle cell lymphoma (MCL).


METHODS
We analyzed SOX11 expression in 349 B-cell non-Hodgkin lymphomas (B-NHLs) via immunohistochemistry.


RESULTS
Nuclear staining of SOX11 was observed in 54 (93.1%) of 58 MCLs. We noticed that SOX11 protein was also expressed on the nuclei in 8 (21.6%) of 37 B-lymphoblastic lymphomas, 45 (32.6%) of 138 diffuse large B-cell lymphomas, 15 (44.1%) of 34 follicular lymphomas, 8 (30.8%) of 26 Burkitt lymphomas, 2 (10.0%) of 20 chronic lymphocytic leukemia/small cell lymphomas, and 3 (18.8%) of 16 marginal zone lymphomas.


CONCLUSIONS
Although the positive rate of SOX11 expression in MCL was significantly higher than other B-NHLs (P < .001), polyclonal antibody targeting SOX11 is not able to identify MCL from B-NHLs because the nuclear staining of SOX11 was widely positive in B-NHLs.
['Zhang|Li-Na|LN|', 'Cao|Xin|X|', 'Lu|Ting-Xun|TX|', 'Fan|Lei|L|', 'Wang|Li|L|', 'Xu|Ji|J|', 'Zhang|Run|R|', 'Zou|Zhi-Jian|ZJ|', 'Wu|Jia-Zhu|JZ|', 'Li|Jian-Yong|JY|', 'Xu|Wei|W|']
D000906:Antibodies D014408:Biomarkers, Tumor D006801:Humans D007150:Immunohistochemistry D016393:Lymphoma, B-Cell D020522:Lymphoma, Mantle-Cell D055751:SOXC Transcription Factors
Polyclonal antibody SOX11 Mantle cell lymphoma B-cell non-Hodgkin lymphoma Immunohistochemistry