Dedifferentiated Chondrosarcoma of the Larynx.
Primary dedifferentiated chondrosarcoma occurring in the larynx is a rare head and neck malignancy. The cases reported in the literature suggest male gender predilection and variable clinical outcomes ranging from disease-free survival to disease-related death. Although a calcified matrix is suggestive of chondrosarcoma, the dedifferentiated component is not readily appreciated on conventional imaging modalities and thorough tissue sampling is necessary for confirming the diagnosis. Histologically, there is an abrupt transition from a well-differentiated chondrosarcoma to a high-grade spindle cell component, which can show focal heterologous differentiation. These features are exemplified in this sine qua non radiology-pathology correlation article.
['Fidai|Shiraz S|SS|http://orcid.org/0000-0001-8063-5046', 'Ginat|Daniel T|DT|', 'Langerman|Alexander J|AJ|', 'Cipriani|Nicole A|NA|']
D001859:Bone Neoplasms D002454:Cell Differentiation D002813:Chondrosarcoma D006801:Humans D007822:Laryngeal Neoplasms D008297:Male D008875:Middle Aged
Larynx Primary dedifferentiated chondrosarcoma Head and neck malignancy Well-differentiated chondrosarcoma Heterologous differentiation Cricoid cartilage