Concentrated growth factor in the treatment of adjacent multiple gingival recessions: a split-mouth randomized clinical trial.
AIM
The aim of this study was to determine the clinical effect of concentrated growth factor (CGF) in combination with coronally advanced flap (CAF) compared to CAF alone for the treatment of multiple adjacent gingival recessions (GRs).


MATERIALS AND METHODS
Twenty patients with a total of 119 Miller Class I and II GRs in the maxilla were included to this study. Recessions were randomly treated according to a split-mouth design by means of CAF + CGF (test; 60 defects) or CAF (control; 59 defects). Clinical outcomes were evaluated at baseline and 6 months after surgery.


RESULTS
The mean root coverage (MRC) was 82.06% and 86.67%, complete root coverage (CRC) was 45.8% (27/59) and 56.7% (34/60) for CAF and CAF + CGF, respectively at 6th month. Statistically no difference was demonstrated between the two groups in terms of recession depth (RD), MRC and CRC at 6th month. The increase in width of keratinized gingiva (KGW) and gingival thickness (GT) were statistically significant in the CAF + CGF group compared to the CAF group at 6th month.


CONCLUSIONS
The use of CGF in combination with CAF did not provide additional benefits in RD, CRC and MRC. This study suggests that use of CGF + CAF may increase the success of GRs because of a significant increase in KGW and GT.
['Bozkurt Doğan|Şeyma|Ş|', 'Öngöz Dede|Figen|F|', 'Ballı|Umut|U|', 'Atalay|Elif N|EN|', 'Durmuşlar|Mustafa C|MC|']
D000328:Adult D003131:Combined Modality Therapy D003238:Connective Tissue D005260:Female D005500:Follow-Up Studies D005889:Gingival Recession D005893:Gingivoplasty D006801:Humans D036341:Intercellular Signaling Peptides and Proteins D008297:Male D008875:Middle Aged D011379:Prognosis D013524:Surgical Flaps D014092:Tooth Root D055815:Young Adult
concentrated growth factor growth factor gingival recession root coverage plastic surgery platelet-rich fibrin