Brain-derived neurotrophic factor, a new soluble biomarker for malignant pleural mesothelioma involved in angiogenesis.
Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer related to asbestos exposure. The discovery of soluble biomarkers with diagnostic/prognostic and/or therapeutic properties would improve therapeutic care of MPM patients. Currently, soluble biomarkers described present weaknesses preventing their use in clinic. This study aimed at evaluating brain-derived neurotrophic factor (BDNF), we previously identified using transcriptomic approach, in MPM. We observed that high BDNF expression, at the mRNA level in tumors or at the protein level in pleural effusions (PE), was a specific hallmark of MPM samples. This protein presented significant but limited diagnostic properties (area under the curve (AUC) = 0.6972, p < 0.0001). Interestingly, high BDNF gene expression and PE concentration were predictive of shorter MPM patient survival (13.0 vs 8.3 months, p < 0.0001, in PE). Finally, BDNF did not affect MPM cell oncogenic properties but was implicated in PE-induced angiogenesis. In conclusion, BDNF appears to be a new interesting biomarker for MPM and could also be a new therapeutic target regarding its implication in angiogenesis.
['Smeele|Patrick|P|', "d'Almeida|Sènan Mickaël|SM|", 'Meiller|Clément|C|', 'Chéné|Anne-Laure|AL|', 'Liddell|Charly|C|', 'Cellerin|Laurent|L|', 'Montagne|François|F|', 'Deshayes|Sophie|S|', 'Benziane|Sarah|S|', 'Copin|Marie-Christine|MC|', 'Hofman|Paul|P|', 'Le Pimpec-Barthes|Françoise|F|', 'Porte|Henri|H|', 'Scherpereel|Arnaud|A|', 'Grégoire|Marc|M|', 'Jean|Didier|D|', 'Blanquart|Christophe|C|0000-0002-0917-3747']
D014408:Biomarkers, Tumor D019208:Brain-Derived Neurotrophic Factor D015870:Gene Expression D006801:Humans D008175:Lung Neoplasms D008654:Mesothelioma D000086002:Mesothelioma, Malignant D009389:Neovascularization, Pathologic D016066:Pleural Effusion, Malignant D010997:Pleural Neoplasms D011379:Prognosis D012333:RNA, Messenger D012372:ROC Curve
Biomarkers Mesothelioma Angiogenesis BDNF Pleural effusions