The Role and Mechanism of Epithelial-to-Mesenchymal Transition in Prostate Cancer Progression.
In prostate cancer (PCa), similar to many other cancers, distant organ metastasis symbolizes the beginning of the end disease, which eventually leads to cancer death. Many mechanisms have been identified in this process that can be rationalized into targeted therapy. Among them, epithelial-to-mesenchymal transition (EMT) is originally characterized as a critical step for cell trans-differentiation during embryo development and now recognized in promoting cancer cells invasiveness because of high mobility and migratory abilities of mesenchymal cells once converted from carcinoma cells. Nevertheless, the underlying pathways leading to EMT appear to be very diverse in different cancer types, which certainly represent a challenge for developing effective intervention. In this article, we have carefully reviewed the key factors involved in EMT of PCa with clinical correlation in hope to facilitate the development of new therapeutic strategy that is expected to reduce the disease mortality.
['Lo|U-Ging|UG|', 'Lee|Cheng-Fan|CF|', 'Lee|Ming-Shyue|MS|', 'Hsieh|Jer-Tsong|JT|']
D000818:Animals D018450:Disease Progression D044127:Epigenesis, Genetic D058750:Epithelial-Mesenchymal Transition D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008297:Male D035683:MicroRNAs D009361:Neoplasm Invasiveness D011467:Prostate D011471:Prostatic Neoplasms D062085:RNA, Long Noncoding
epithelial-to-mesenchymal transition prostate cancer progression metastasis