The anorexigenic effect of adrenomedullin in Japanese quail (Coturnix japonica) involves increased proopiomelanocortin and cocaine- and amphetamine-regulated transcript mRNAs in the arcuate nucleus of the hypothalamus.
Central administration of adrenomedullin (AM), a 52-amino acid peptide, is associated with anorexigenic effects in some species, including rodents and chickens. However, the associated hypothalamic mechanisms remain unclear and it is unknown if this peptide exerts satiety-inducing effects in other avian species. The objective of this study was thus to investigate AM-induced anorexigenic effects in 7-day-old Japanese quail (Coturnix japonica). After intracerebroventricular injection of 0.3, 1.0, or 3.0 nmol of AM, quail injected with 3.0 nmol of AM ate and drank less than vehicle-injected quail at 180 min after injection. Except for the 1.0 nmol dose of AM exerting an anorexigenic effect at 90 min after injection, no other inhibitory effects on food or water intake were observed. At 60 min after injection, the AM-injected quail had more c-Fos immunoreactive cells in the arcuate nucleus (ARC) than vehicle-injected birds. In the ARC, AM injection was associated with increased proopiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) mRNAs. In conclusion, the results suggest that the anorexigenic effect of AM is possibly influenced by the synergistic effect of POMC and CART in the ARC.
['Wang|J|J|', 'Webster|A|A|', 'Sims|W|W|', 'Gilbert|E R|ER|', 'Cline|M A|MA|']
D053607:Adrenomedullin D000818:Animals D000959:Antihypertensive Agents D001111:Arcuate Nucleus of Hypothalamus D003370:Coturnix D005247:Feeding Behavior D009419:Nerve Tissue Proteins D011333:Pro-Opiomelanocortin D016760:Proto-Oncogene Proteins c-fos D012333:RNA, Messenger
Adrenomedullin Quail Proopiomelanocortin Cocaine- and amphetamine-regulated transcript Arcuate nucleus