Interferon therapies in small animals.
Interferons (IFNs) are cytokines that play an important role in the immune response of animals and humans. A number of studies reviewed here have evaluated the use of human, canine and feline IFNs as treatments for infectious, inflammatory and neoplastic disease in dogs and cats. Recombinant canine IFN-γ is deemed an efficacious therapy for canine atopic dermatitis. Recombinant feline IFN-ω is effective against canine parvoviral enteritis and has also been recommended for canine atopic dermatitis. Based on limited evidence, recombinant canine IFN-α could be a topical treatment option for dogs with gingivitis and keratoconjunctivitis sicca. Conclusive evidence is lacking for other diseases and large randomised controlled trials are needed before IFNs can be recommended for other indications.
['Mueller|Ralf S|RS|', 'Hartmann|Katrin|K|']
D000818:Animals D002371:Cat Diseases D002415:Cats D004283:Dog Diseases D004285:Dogs D005891:Gingivitis D006801:Humans D007239:Infections D007249:Inflammation D016898:Interferon-alpha D007372:Interferons D007638:Keratoconjunctivitis Sicca D009369:Neoplasms D011994:Recombinant Proteins D014777:Virus Diseases
Dog Cat IFN-γ IFN-ω IFN-α