Biomimetic Total Synthesis of (±)-Homodimericin A.
A biomimetic total synthesis of racemic homodimericin A was achieved in seven steps, including two cascade reactions. Aqueous buffer solutions are found to help both the oxidative dimerization cascade and the intramolecular Diels-Alder cascade. This synthetic sequence validates key steps in the biogenetic proposal of homodimericin A.
['Ma|Donghui|D|', 'Liu|Yangbin|Y|', 'Wang|Zhang|Z|0000-0001-5659-0036']
total synthesis homodimericin cascade reactions Negishi coupling biomimetic synthesis