Notch in fibrosis and as a target of anti-fibrotic therapy.
The Notch pathway represents a highly conserved signaling network with essential roles in regulation of key cellular processes and functions, many of which are critical for development. Accumulating evidence indicates that it is also essential for fibrosis and thus the pathogenesis of chronic fibroproliferative diseases in diverse organs and tissues. Different effects of Notch activation are observed depending on cellular and tissue context as well as in both physiologic and pathologic states. Close interactions of Notch signaling pathway with other signaling pathways have been identified. In this review, current knowledge on the role of the Notch signaling with special focus on fibrosis and its potential as a therapeutic target is summarized.
['Hu|Biao|B|', 'Phan|Sem H|SH|']
D000818:Animals D049109:Cell Proliferation D058750:Epithelial-Mesenchymal Transition D005355:Fibrosis D006801:Humans D007668:Kidney D008099:Liver D008103:Liver Cirrhosis D008168:Lung D058628:Myofibroblasts D011658:Pulmonary Fibrosis D051880:Receptors, Notch D051436:Renal Insufficiency, Chronic D015398:Signal Transduction D012867:Skin
Notch Fibrosis Myofibroblast