Case Definition of Chronic Pulmonary Aspergillosis in Resource-Constrained Settings.
Chronic pulmonary aspergillosis (CPA) is a recognized complication of pulmonary tuberculosis (TB). In 2015, the World Health Organization reported 2.2 million new cases of nonbacteriologically confirmed pulmonary TB; some of these patients probably had undiagnosed CPA. In October 2016, the Global Action Fund for Fungal Infections convened an international expert panel to develop a case definition of CPA for resource-constrained settings. This panel defined CPA as illness for >3 months and all of the following: 1) weight loss, persistent cough, and/or hemoptysis; 2) chest images showing progressive cavitary infiltrates and/or a fungal ball and/or pericavitary fibrosis or infiltrates or pleural thickening; and 3) a positive Aspergillus IgG assay result or other evidence of Aspergillus infection. The proposed definition will facilitate advancements in research, practice, and policy in lower- and middle-income countries as well as in resource-constrained settings.
['Denning|David W|DW|', 'Page|Iain D|ID|', 'Chakaya|Jeremiah|J|', 'Jabeen|Kauser|K|', 'Jude|Cecilia M|CM|', 'Cornet|Muriel|M|', 'Alastruey-Izquierdo|Ana|A|', 'Bongomin|Felix|F|', 'Bowyer|Paul|P|', 'Chakrabarti|Arunaloke|A|', 'Gago|Sara|S|', 'Guto|John|J|', 'Hochhegger|Bruno|B|', 'Hoenigl|Martin|M|', 'Irfan|Muhammad|M|', 'Irurhe|Nicholas|N|', 'Izumikawa|Koichi|K|', 'Kirenga|Bruce|B|', 'Manduku|Veronica|V|', 'Moazam|Samihah|S|', 'Oladele|Rita O|RO|', 'Richardson|Malcolm D|MD|', 'Tudela|Juan Luis Rodriguez|JLR|', 'Rozaliyani|Anna|A|', 'Salzer|Helmut J F|HJF|', 'Sawyer|Richard|R|', 'Simukulwa|Nasilele F|NF|', 'Skrahina|Alena|A|', 'Sriruttan|Charlotte|C|', 'Setianingrum|Findra|F|', 'Wilopo|Bayu A P|BAP|', 'Cole|Donald C|DC|', 'Getahun|Haileyesus|H|']
D002908:Chronic Disease D003906:Developing Countries D006801:Humans D017410:Practice Guidelines as Topic D055732:Pulmonary Aspergillosis D012959:Socioeconomic Factors
resource-constrained settings Tuberculosis imaging Aspergillus antibody aspergilloma developing countries fungi tuberculosis and other mycobacteria