Loss of fundus view as an indication for secondary enucleation in retinoblastoma.
In this retrospective study, we evaluated loss of fundus view as an indication for secondary enucleation and associated histopathologic findings. Of 64 secondarily enucleated eyes, 24 were enucleated for loss of fundus view. Average time from loss of fundus view to enucleation was 4.7 months. Of these eyes, 22 had viable tumor cells on histopathology, but none had high-risk features. Loss of fundus view was a common indication for secondary enucleation after chemoreduction. Given the high prevalence of viable histopathologic tumor cells, enucleation for loss of fundus view should not be significantly delayed to decrease risk of high-risk tumor progression.
['Berry|Jesse L|JL|0000-0002-8907-9100', 'Kogachi|Kaitlin|K|', 'Jubran|Rima|R|', 'Kim|Jonathan W|JW|']
D015353:Eye Enucleation D005260:Female D005654:Fundus Oculi D006801:Humans D008297:Male D019572:Retinal Neoplasms D012175:Retinoblastoma D013997:Time Factors
loss of fundus view secondary enucleation retinoblastoma high-risk histopathology