Clinical application values of neutrophil-to-lymphocyte ratio in intracranial aneurysms.
Inflammation plays an important role in the pathogenesis and growth of intracranial aneurysms (IAs). We investigated the clinical value of the neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic subclinical inflammation in patients with IAs. Consecutive patients with IAs who underwent endovascular treatment (EVT) were enrolled in the study. The evaluation indicators were aneurysm size and rupture, a poor outcome at 3 to 6 months, and delayed cerebral ischemia (DCI) during hospitalization. In total, 532 patients with IAs underwent EVT (mean age, 54.0 years; 62.4% female). Among patients with ruptured IAs, those with a higher NLR had an increased risk of a poor outcome at 3 to 6 months and DCI during hospitalization than those with a lower NLR. A higher NLR was significantly more strongly associated with the size of unruptured aneurysms and aneurysm rupture than a lower NLR. The NLR and C-reactive protein concentration showed similar predictive ability for aneurysm size and treatment prognosis. The NLR was lower at discharge than admission for patients with ruptured IAs and DCI. An elevated NLR was significantly associated with the size of unruptured IAs, an increased risk of a poor outcome, and DCI in patients with ruptured IAs.
['Zhang|Baorui|B|', 'Lin|Lin|L|', 'Yuan|Fei|F|', 'Song|Guangrong|G|', 'Chang|Qing|Q|', 'Wu|Zhongxue|Z|', 'Miao|Zhongrong|Z|', 'Mo|Dapeng|D|', 'Huo|Xiaochuan|X|', 'Liu|Aihua|A|']
D000328:Adult D000368:Aged D017542:Aneurysm, Ruptured D002545:Brain Ischemia D002097:C-Reactive Protein D057510:Endovascular Procedures D005260:Female D006760:Hospitalization D006801:Humans D002532:Intracranial Aneurysm D007958:Leukocyte Count D018655:Lymphocyte Count D008214:Lymphocytes D008297:Male D008875:Middle Aged D009504:Neutrophils D011183:Postoperative Complications D011379:Prognosis D012422:Rupture, Spontaneous
neutrophil-to-lymphocyte ratio aneurysm inflammation endovascular treatment