Reversal Strategies for Newer Oral Anticoagulants.
Nonvitamin K antagonist oral anticoagulants have advantages compared with warfarin, but both types of anticoagulants come with uncertainty about how best to manage life-threatening bleeding events, urgent surgeries, and invasive procedures. Nurse practitioners and physician assistants may need to manage such emergency situations in the critical care setting. Achieving hemostasis quickly is key, and efforts to do so have relied mainly on blood products. Targeted reversal agents are in clinical development and one, idarucizumab, which reverses dabigatran anticoagulation, has been approved. Current options for managing events and urgent procedures in anticoagulated patients are discussed in this article, with a focus on specific reversal agents.
['Singer|Adam J|AJ|', 'Wilson|Susan|S|']
D000284:Administration, Oral D000328:Adult D000368:Aged D000369:Aged, 80 and over D061067:Antibodies, Monoclonal, Humanized D000925:Anticoagulants D001777:Blood Coagulation D000069604:Dabigatran D005260:Female D006470:Hemorrhage D006801:Humans D008297:Male D008875:Middle Aged D014481:United States
reversal anticoagulation nonvitamin K antagonist oral anticoagulant NOAC management of bleeding event