Therapeutic management of ventricular arrhythmias in Andersen-Tawil syndrome.
Andersen-Tawil Syndrome (ATS) is a rare periodic paralysis with typical skeletal and neuromuscular features. Cardiac involvement may range from asymptomatic ventricular arrhythmias to sudden death. Its management remains challenging and the choice between antiarrhythmic drug therapy and implantable cardioverter defibrillator (ICD) is not simple. We present a case of ATS patient with episodes of bidirectional ventricular tachycardia, well controlled by flecainide therapy initially, which in particular conditions of fever and hypokaliemia had a cardiac arrest with ventricular fibrillation, with neurological sequelae and need of an ICD implant. A review of the therapeutic management of this disease is presented.
['Maffè|Stefano|S|', 'Paffoni|Paola|P|', 'Bergamasco|Luca|L|', 'Dellavesa|Pierfranco|P|', 'Zenone|Franco|F|', 'Baduena|Lara|L|', 'Franchetti Pardo|Nicolò|N|', 'Careri|Giulia|G|', 'Facchini|Emanuela|E|', 'Sansone|Valeria|V|', 'Parravicini|Umberto|U|']
D050030:Andersen Syndrome D000889:Anti-Arrhythmia Agents D016757:Death, Sudden, Cardiac D017147:Defibrillators, Implantable D004562:Electrocardiography D005424:Flecainide D006801:Humans D017180:Tachycardia, Ventricular
Andersen-Tawil syndrome Bidirectional ventricular tachycardia Subcutaneous implantable cardioverter defibrillator