Preoperative Serum Leptin Level Is Associated with Preoperative Pain Threshold and Postoperative Analgesic Consumption in Patients Undergoing Cesarean Section.
OBJECTIVE
This study aimed to investigate the preoperative level of serum leptin in cesarean section (C-section) patients with and without acute labor pain and its association with postoperative analgesic consumption and preoperative pain threshold.


MATERIALS AND METHODS
Preoperative leptin levels, preoperative pain threshold, postoperative analgesic consumption in the first 24 h, and postoperative pain severity (visual analog scale (VAS) scores at 1, 2, 4, 6, 12, and 24 h postoperatively) in C-section patients with labor pain (emergency C-section; n = 21) and without labor pain (elective C-section; n = 25) were compared.


RESULTS
There were no signiﬁcant differences between the groups regarding the demographic characteristics. Leptin levels, postoperative VAS scores, and analgesic consumption were significantly higher in the group with labor pain, while the preoperative pain threshold was lower. Serum leptin levels correlated negatively with pain threshold and positively with postoperative analgesic consumption. Multiple linear regression analyses in our study revealed that the preoperative leptin levels and having an emergency C-section independently affected the postoperative analgesic consumption and preoperative pain threshold, whereas their combined effects on these parameters were statistically not significant.


CONCLUSION
Preoperative levels of serum leptin were higher in C-section patients with labor pain than in those without labor pain, and increased serum leptin levels were associated with decreased preoperative pain threshold and increased postoperative analgesic consumption in our study population. Postoperative analgesic requirements may vary among patients, and their requirements might be predicted using preoperative indicators. Serum levels of leptin might be one such indicator and this warrants further studies with larger sample sizes.
['Seringec Akkececi|Nurten|N|', 'Oksuz|Gozen|G|', 'Urfalioğlu|Aykut|A|', 'Gunesacar|Ramazan|R|', 'Bakacak|Murat|M|', 'Arslan|Mahmut|M|', 'Kelleci|Bekir Mehmet|BM|']
D000328:Adult D000701:Analgesics, Opioid D002585:Cesarean Section D005260:Female D006801:Humans D048949:Labor Pain D020738:Leptin D010147:Pain Measurement D017288:Pain Threshold D010149:Pain, Postoperative D011247:Pregnancy D055815:Young Adult
Leptin Pain threshold Postoperative analgesic consumption Labor pain Visual analog scale