Diabetes mellitus might be a protective factor of glioma.
Aims
Several studies suggested that diabetes mellitus (DM) was associated with the risk of glioma. However, other studies did not confirm the result. Therefore, I conducted this meta-analysis.


Materials and Methods
I retrieved the PubMed, Embase, and Web of Science database, by adopting keywords "glioma," and "diabetes," "DM." The strength of the associations between DM and the risk of glioma was measured by odds ratios (ORs) with 95% confidence intervals (95% CIs).


Results
Ten relevant studies were identified in the final analysis. A statistically significant association between DM and glioma risk was fond (OR = 0.84; 95% CI, 0.73-0.97; P = 0.02). In the subgroup analysis of age group, young population with DM showed decreased glioma risk (OR = 0.83; 95% CI, 0.70-0.98; P = 0.02), whereas old population with DM did not show a significant association (OR = 0.87; 95% CI, 0.65-1.16; P = 0.34). In the subgroup analysis of gender, male patients with DM showed decreased glioma risk (OR = 0.82; 95% CI, 0.68-0.99; P = 0.04), whereas female population with DM did not show a significant association (OR = 0.93; 95% CI, 0.70-1.24; P = 0.63).


Conclusions
This meta-analysis suggested that DM may be associated with the reduced glioma risk.
['Ni|Ting-Ting|TT|']
D000328:Adult D000367:Age Factors D000368:Aged D048909:Diabetes Complications D003920:Diabetes Mellitus D005260:Female D005910:Glioma D006801:Humans D008297:Male D008875:Middle Aged D065840:Protective Factors D012307:Risk Factors D012727:Sex Characteristics D012737:Sex Factors
diabetes mellitus glioma Association meta-analysis