Impact of Vitamin D Supplementation on Semen Quality in Vitamin D-Deficient Infertile Males with Oligoasthenozoospermia.
Introduction
Male factor contributes to almost 50% cases of infertility. There is evidence of the effect of serum vitamin D on male fertility by helping in spermatozoa maturation and initiating acrosomal reaction. In India, vitamin D deficiency has been documented to be in the range of 50-90% among all the age groups.


Objective
To study the levels of vitamin D and the impact of vitamin D supplementation in vitamin D-insufficient/deficient infertile males with oligoasthenozoospermia.


Material and methods
This study is a longitudinal observation study. Infertile men with either oligozoospermia or asthenozoospermia with vitamin D levels < 30 ng/ml were enrolled. Vitamin D and calcium supplementation was given, and semen and hormone parameters were assessed at the end of 3 and 6 months.


Result
There is significant improvement in the mean sperm concentration and progressive sperm motility in infertile males with oligoasthenozoospermia after 6 months of vitamin D supplementation (p value < 0.001). The overall clinical pregnancy rate in the study was 8.33% after vitamin D supplementation (p value 0.24).


Conclusion
Vitamin D supplementation plays a crucial role in regulating male fertility.
['Wadhwa|Leena|L|', 'Priyadarshini|Srishti|S|', 'Fauzdar|Ashish|A|', 'Wadhwa|Sanjana N|SN|', 'Arora|Sarika|S|']
Oligoasthenozoospermia Vitamin D deficiency Sperm concentration Sperm motility Male infertility