Gestational diabetes affects fetal autophagy.
Autophagy is a catabolic process involved in the preservation of energy homeostasis and its dysregulation has been implicated in the development of metabolic disorders, including diabetes mellitus. Gestational diabetes mellitus represents a risk for fetal morbidity and mortality. The present study focuses on the autophagy process in human diabetic placenta and fetal pancreas, compared with controls. Analysis of the autophagy markers LC3, Beclin-1 and p62 suggests an impairment of the autophagy process in diabetic placentas. Results indicate an association between gestational diabetes and autophagy, emphasizing the importance of unravelling the mechanisms regulating this relationship.
['Avagliano|Laura|L|', 'Massa|Valentina|V|', 'Terraneo|Laura|L|', 'Samaja|Michele|M|', 'Doi|Patrizia|P|', 'Bulfamante|Gaetano Pietro|GP|', 'Marconi|Anna Maria|AM|']
D000328:Adult D001343:Autophagy D015415:Biomarkers D016022:Case-Control Studies D016640:Diabetes, Gestational D005260:Female D005333:Fetus D006801:Humans D008869:Microtubule-Associated Proteins D010179:Pancreas D010920:Placenta D011247:Pregnancy
Diabetes Autophagy Placenta LC3 Beclin-1 p62 Pregnancy