Qualitative study of barriers to clinical trial retention in adults with recently diagnosed type 1 diabetes.
OBJECTIVES
Regular physical exercise may preserve β cell function in newly diagnosed adults with type 1 diabetes (T1D). However, clinical trials to test this theory require the recruitment and retention of adults with new-onset T1D, which can be challenging. We sought to determine the overall experiences of newly diagnosed adults with T1D in an exercise study, to understand issues that influence the retention of trial participants in such studies.


DESIGN
Qualitative methodology using individual face-to-face (n=6) and telephone interviews (n=14). Interview transcripts were thematically analysed using the framework method.


SETTING
The study took place at five participating UK hospitals.


PARTICIPANTS
Twenty participants, aged 19-55 years, in the Exercise for Type 1 Diabetes study were interviewed to explore their study experiences and identify motivators and deterrents towards the study. Participants in control and intervention arms were interviewed, as were people with T1D who had completed (n=16) and withdrawn (n=4).


RESULTS
Participants revealed barriers and facilitators to retention; the majority were generalisable to clinical trials of people with newly diagnosed T1D. Coming to terms with a diagnosis of T1D, lack of time, work pressures, level of health professional support, volume, clarity and consistency of information and feedback and a desire for knowledge about their condition were all cited as influencing factors to trial retention.


CONCLUSIONS
To our knowledge, this is the first qualitative study to examine the experience of being involved in an exercise trial by people with T1D. Findings suggest appointments could be shorter, available outside of working hours and planned longer in advance; study information should be clear, consistent and in electronic and paper formats; questionnaires need minimising; healthcare support and feedback needs providing regularly; thought is required around how to support non-exercising arm participants. These considerations may improve participant retention rates in new-onset T1D studies.
['Henshall|Catherine|C|0000-0001-5659-3296', 'Narendran|Parth|P|', 'Andrews|Robert C|RC|', 'Daley|Amanda|A|', 'Stokes|Keith A|KA|', 'Kennedy|Amy|A|', 'Greenfield|Sheila|S|']
D000328:Adult D002986:Clinical Trials as Topic D003922:Diabetes Mellitus, Type 1 D004651:Employment D015444:Exercise D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D018579:Patient Selection D036301:Qualitative Research D035842:Research Subjects D000076522:Retention in Care D012944:Social Support D013997:Time Factors D006113:United Kingdom D055815:Young Adult
clinical trials trial retention type 1 diabetes exercise participants physical activity