Modification of nanocellulose by poly-lysine can inhibit the effect of fumonisin B1 on mouse liver cells.
Fumonisin B1 is an important mycotoxin, mainly produced by Fusarium verticillioides. It has toxic effects on liver, brain, and kidney cells. The first aim of this study was to synthesize nanocellulose modified with poly-lysine (NMPL), and the second aim was to evaluate the adsorption of fumonisin B1 by NMPL. As third aim, the function of mouse liver cells was investigated after exposure to fumonisin B1, and fumonisin B1+ NMPL. In this study, NMPL was prepared using cross-linker, and then incubated with fumonisin B1 at controlled conditions. After incubation, the adsorption and release of fumonisin B1 were evaluated in each condition. Next, mouse liver cells were separately exposed to fumonisin B1, NMPL, and (fumonisin B1+NMPL). Then, the level of aniline aminotransferase (ALT) and aspartate aminotransferase (AST) was evaluated. It was found that both adsorption and release of fumonisin B1 were not affected by temperature and incubation time, but affected by pH and concentration of NMPL. Also, this study showed NMPL could adsorb fumonisin B1 in different foodstuffs. Importantly, although the levels of ALT and AST were increased when the cells were treated with fumonisin B1 alone, they were not affected when exposed to NMPL or (fumonisin B1+NMPL). The authors suggest that NMPL is a good adsorbent to remove and inhibit fumonisin B1.
['Jebali|Ali|A|', 'Yasini Ardakani|Seyed Ali|SA|', 'Shahdadi|Hossein|H|', 'Balal Zadeh|Mohammad Hossein|MH|', 'Hekmatimoghaddam|Seyedhossein|S|']
D000327:Adsorption D000818:Animals D002482:Cellulose D004305:Dose-Response Relationship, Drug D037341:Fumonisins D006863:Hydrogen-Ion Concentration D008099:Liver D008297:Male D051379:Mice D008807:Mice, Inbred BALB C D008958:Models, Molecular D015394:Molecular Structure D049329:Nanostructures D011107:Polylysine D013329:Structure-Activity Relationship D013696:Temperature
Nanocellulose Poly-lysine Fumonisin B1 Liver Adsorption