Enteral Guanfacine to Treat Severe Anxiety and Agitation Complicating Critical Care After Cardiac Surgery.
This article is the first reported case describing the off-label use of enteral immediate-release guanfacine, a long-acting α-2 adrenergic agonist most commonly used in the treatment of attention-deficit hyperactivity disorder, for sedation in a patient with severe anxiety and agitation limiting mechanical ventilation weaning several days after cardiac surgery. In this case, after several days of unsuccessful attempts to control his agitation and anxiety with conventional therapies, guanfacine therapy was initiated, and the patient was rapidly weaned from all other sedatives and mechanical ventilation shortly thereafter. The patient was weaned from guanfacine therapy without evidence of bradycardia, hypotension, or rebound syndrome. Enteral guanfacine therapy should be further studied as a potentially useful and cost-effective sedative therapy for patients with severe anxiety and/or agitation in the intensive care unit following cardiac and thoracic surgical procedures.
['Srour|Habib|H|', 'Pandya|Komal|K|', 'Flannery|Alex|A|', 'Hatton|Kevin|K|']
D058647:Adrenergic alpha-2 Receptor Agonists D000328:Adult D001007:Anxiety D006348:Cardiac Surgical Procedures D003422:Critical Care D016316:Guanfacine D006801:Humans D007362:Intensive Care Units D008297:Male D011595:Psychomotor Agitation D012121:Respiration, Artificial D012720:Severity of Illness Index D015300:Ventilator Weaning
critical care intensive care unit cognitive dysfunction postoperative care withdrawal