Layer-by-layer assembled thin films and microcapsules of nanocrystalline cellulose for hydrophobic drug delivery.
A layer-by-layer (LbL) approach has been employed for the fabrication of multilayer thin films and microcapsules having nanofibrous morphology using nanocrystalline cellulose (NCC) as one of the components of the assembly. The applicability of these nanoassemblies as drug delivery carriers has been explored by the loading of an anticancer drug, doxorubicin hydrochloride, and a water-insoluble drug, curcumin. Doxorubicin hydrochloride, having a good water solubility, is postloaded in the assembly. In the case of curcumin, which is very hydrophobic and has limited solubility in water, a stable dispersion is prepared via noncovalent interaction with NCC prior to incorporation in the LbL assembly. The interaction of various other lipophilic drugs with NCC was analyzed theoretically by molecular docking in consideration of NCC as a general carrier for hydrophobic drugs.
['Mohanta|Vaishakhi|V|', 'Madras|Giridhar|G|', 'Patil|Satish|S|']
D002214:Capsules D002482:Cellulose D048271:Chitosan D003474:Curcumin D004317:Doxorubicin D004337:Drug Carriers D065546:Drug Liberation D006863:Hydrogen-Ion Concentration D057927:Hydrophobic and Hydrophilic Interactions D053758:Nanoparticles D012995:Solubility
layer-by-layer hydrophobic drug delivery multilayers NCC