Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy
Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial phase in the pathophysiological process of SCI concerns the well-known secondary injury, which is the uncontrolled and destructive cascade occurring later with aberrant molecular signaling, inflammation, vascular changes, and secondary cellular dysfunctions. The use of mesenchymal stem cells (MSCs) represents one of the most important and promising tested strategies. Their appeal, among the other sources and types of stem cells, increased because of their ease of isolation/preservation and their properties. Nevertheless, encouraging promise from preclinical studies was followed by weak and conflicting results in clinical trials. In this review, the therapeutic role of MSCs is discussed, together with their properties, application, limitations, and future perspectives.
['Cofano|Fabio|F|', 'Boido|Marina|M|0000-0003-1211-1552', 'Monticelli|Matteo|M|', 'Zenga|Francesco|F|', 'Ducati|Alessandro|A|', 'Vercelli|Alessandro|A|', 'Garbossa|Diego|D|']
D000818:Animals D001672:Biocompatible Materials D015415:Biomarkers D064987:Cell- and Tissue-Based Therapy D036101:Cord Blood Stem Cell Transplantation D004195:Disease Models, Animal D006801:Humans D045164:Mesenchymal Stem Cell Transplantation D059630:Mesenchymal Stem Cells D009414:Nerve Growth Factors D009416:Nerve Regeneration D044968:Regenerative Medicine D013119:Spinal Cord Injuries D058630:Spinal Cord Regeneration D054457:Tissue Scaffolds D057170:Translational Research, Biomedical
mesenchymal stem cells spinal cord injury regenerative medicine translational medicine