Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy.
Fluorescent theranostics probes at the second near-IR region (NIR-II; 1.0-1.7 µm) are in high demand for precise theranostics that minimize autofluorescence, reduce photon scattering, and improve the penetration depth. Herein, we designed and synthesized an NIR-II theranostic nanoprobe 1 that incorporates a Pt(II) metallacycle 2 and an organic molecular dye 3 into DSPE-mPEG5000 (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000]). This design endows 1 with good photostability and passive targeting ability. Our studies show that 1 accurately diagnoses cancer with high resolution and selectively delivers the Pt(II) metallacycle to tumor regions via an enhanced permeability and retention effect. In vivo studies reveal that 1 efficiently inhibits the growth of tumor with minimal side effects. At the same time, improved fluorescent imaging quality and signal-to-noise ratios are shown due to the long emission wavelengths. These studies demonstrate that 1 is a potential theranostic platform for tumor diagnosis and treatment in the NIR-II region.
['Sun|Yue|Y|', 'Ding|Feng|F|', 'Zhou|Zhixuan|Z|', 'Li|Chonglu|C|', 'Pu|Maoping|M|', 'Xu|Yuling|Y|', 'Zhan|Yibei|Y|', 'Lu|Xiaoju|X|', 'Li|Haibing|H|', 'Yang|Guangfu|G|', 'Sun|Yao|Y|', 'Stang|Peter J|PJ|']
D000818:Animals D008279:Magnetic Resonance Imaging D051379:Mice D008810:Mice, Inbred C57BL D009369:Neoplasms D009374:Neoplasms, Experimental D017785:Photons D059629:Signal-To-Noise Ratio D000068936:Theranostic Nanomedicine
theranostic image-guided therapy metallacycle second near-infrared region supramolecular coordination complexes