The effect of HDL cholesterol on blood and plasma viscosity in healthy subjects.
OBJECTIVE
The influence of lipids on blood and plasma viscosity has not been fully elucidated. In this study we evaluated the contribution of HDL cholesterol to blood and plasma viscosity, in healthy subjects.


METHODS
One hundred and forty-four (80 males and 64 females) subjects were enrolled among free-living participants to a cardiovascular disease screening. Exclusion criteria were: diabetes, elevated triglycerides, elevated LDL cholesterol, smoking and drug use. Blood lipids were measured by routine methods. Blood and plasma viscosity were measured by a cone-plate viscometer (Wells-Brookfield DV-III, Stoughton, U.S.A.). Subjects were divided in two groups: at low (<50 mg/dl) and high HDL cholesterol (>50 mg/dl).


RESULTS
Blood and plasma viscosity were similar in subjects at low and high HDL cholesterol. In univariate analysis none of the lipid variables was significantly correlated with blood and/or plasma viscosity. In multivariate analysis only LDL cholesterol was marginally associated with blood viscosity.


CONCLUSION
HDL cholesterol does not influence blood and plasma viscosity in healthy normolipidemic subjects. LDL cholesterol is marginally associated with blood viscosity.
['Carallo|Claudio|C|', 'Irace|Concetta|C|', 'De Franceschi|Maria S|MS|', 'Esposito|Teresa|T|', 'Tripolino|Cesare|C|', 'Scavelli|Faustina|F|', 'Merante|Valentina|V|', 'Gnasso|Agostino|A|']
D001809:Blood Viscosity D002318:Cardiovascular Diseases D008076:Cholesterol, HDL D008078:Cholesterol, LDL D005260:Female D006801:Humans D006949:Hyperlipidemias D008297:Male D012016:Reference Values D012307:Risk Factors D014280:Triglycerides
HDL plasma viscosity LDL Blood viscosity hyperlipidemia