Recent advances in magnetic resonance imaging for peripheral artery disease.
The global burden of peripheral artery disease (PAD) is significant. This has led to numerous recent advances in magnetic resonance imaging (MRI) techniques in PAD. Older techniques such as time of flight MRI or phase contrast MRI are burdened by long acquisition times and significant issues with artifacts. In addition, the most used MRI modality, contrast-enhanced MR angiography (CE-MRA) is limited by the use of gadolinium contrast and its potential toxicity. Novel MRI techniques such as arterial spin labeling (ASL), blood-oxygen-level dependent imaging (BOLD), and first-pass perfusion gadolinium enhancement are advancing the field by providing skeletal muscle perfusion/oxygenation data while maintaining excellent spatial and temporal resolution. Perfusion data can be critical to providing objective clinical data of a visualized stenosis. In addition, there are a number of new MRI sequences assessing plaque composition and lesion severity in the absence of contrast. These approaches used in combination can provide useful clinical and prognostic data and provide critical endpoints in PAD research.
['Mathew|Roshin C|RC|0000-0002-7927-4607', 'Kramer|Christopher M|CM|']
D001158:Arteries D003287:Contrast Media D006801:Humans D018810:Magnetic Resonance Angiography D008279:Magnetic Resonance Imaging D018482:Muscle, Skeletal D058729:Peripheral Arterial Disease
peripheral artery disease (PAD) magnetic resonance imaging (MRI) arterial spin labeling blood-oxygen-level dependent imaging first-pass gadolinium enhanced imaging magnetic resonance angiography (MRA) magnetic resonance spectroscopy peripheral artery plaque phosphocreatine