Degradability, bioactivity, and osteogenesis of biocomposite scaffolds of lithium-containing mesoporous bioglass and mPEG-PLGA-b-PLL copolymer.
Biocomposite scaffolds of lithium (Li)-containing mesoporous bioglass and monomethoxy poly(ethylene glycol)-poly(D,L-lactide-co-glycolide)-poly(L-lysine) (mPEG-PLGA-b-PLL) copolymer were fabricated in this study. The results showed that the water absorption and degradability of Li-containing mesoporous bioglass/mPEG-PLGA-b-PLL composite (l-MBPC) scaffolds were obviously higher than Li-containing bioglass/mPEG-PLGA-b-PLL composite (l-BPC) scaffolds. Moreover, the apatite-formation ability of l-MBPC scaffolds was markedly enhanced as compared with l-BPC scaffolds, indicating that l-MBPC scaffolds containing mesoporous bioglass exhibited good bioactivity. The cell experimental results showed that cell attachment, proliferation, and alkaline phosphatase activity of MC3T3-E1 cells on l-MBPC scaffolds were remarkably improved as compared to l-BPC scaffolds. In animal experiments, the histological elevation results revealed that l-MBPC scaffolds significantly promoted new bone formation, indicating good osteogenesis. l-MBPC scaffolds with improved properties would be an excellent candidate for bone tissue repair.
['Cai|Yanrong|Y|', 'Guo|Lieping|L|', 'Shen|Hongxing|H|', 'An|Xiaofei|X|', 'Jiang|Hong|H|', 'Ji|Fang|F|', 'Niu|Yunfei|Y|']
D016475:3T3 Cells D000818:Animals D001672:Biocompatible Materials D049109:Cell Proliferation D002516:Ceramics D008094:Lithium D051379:Mice D010012:Osteogenesis D011091:Polyesters D011092:Polyethylene Glycols D011107:Polylysine D054457:Tissue Scaffolds
degradability bioactivity osteogenesis copolymer MBG bone repair cell proliferation