Two new lignans from Saururus chinensis.
Two new lignans, (Z)-14-bis(3',4'-dimethoxyphenyl)-2,3-dimethylbut-2-ene-1,4-dione (1), threo-2-methyl-3-oxo-1-(3',4',5'-trimethoxyphenyl)butyl-3″,4″-dimethoxybenzoate (2), together with 15 known derivatives (3-17) were isolated from Saururus chinensis. Their structures were determined on the basis of spectral data, including 1D and 2D NMR experiments and HREIMS spectra. The antitumour activity was screened by MTT assay, compounds 1, 2, 3, 5, 9-11 and 13-15 showed no cytotoxic activity against HL-60, SMMC-7721, A549, MCF-7 and SW480 cell lines.
['Li|Cuibai|C|', 'Li|Ningxin|N|', 'Yue|Jiarui|J|', 'Song|Qishi|Q|', 'Fan|Qingfei|Q|']
D045744:Cell Line, Tumor D006801:Humans D017705:Lignans D015394:Molecular Structure D010936:Plant Extracts D018517:Plant Roots D032134:Saururaceae D013057:Spectrum Analysis
lignans Saururus chinensis antitumour activity Saururaceae