Improving discrimination in the grading of rat mammary tumors using two-dimensional mapping of histopathological observations.
This work aims at characterizing rat mammary tumors induced by 7,12-dimethylbenz(a)anthracene (DMBA) and the respective malignancy potential, commonly graded with histopathology features grouped by intensity levels. Tumors were described over fourteen multiple ranged microscopic parameters and a comprehensive characterization of the histological patterns and their relation with tumor grade was carried out by principal component analysis (PCA). The number of histological patterns present on a tumor tends to correlate with malignant features. High grade tumors are characterized by the presence of several structural patterns, with cribriform prevalence and necrosis. The cribriform pattern correlates with grading, i.e., tumors having a higher predominance of the cribriform pattern are likely to be more malignant. The findings may represent a benchmark for similar characterization studies in other models.
['Lopes|Ana C|AC|', 'Cova|Tânia F G G|TF|', 'Pais|Alberto A C C|AA|', 'Pereira|Jorge L G F S C|JL|', 'Colaço|Bruno|B|', 'Cabrita|António M S|AM|']
D015127:9,10-Dimethyl-1,2-benzanthracene D000818:Animals D002273:Carcinogens D016002:Discriminant Analysis D005260:Female D008325:Mammary Neoplasms, Experimental D060787:Neoplasm Grading D025341:Principal Component Analysis D051381:Rats D017207:Rats, Sprague-Dawley
Mammary tumors DMBA Principal component analysis Histological grading