Effect of adjunctive ranitidine for antipsychotic-induced weight gain: A systematic review of randomized placebo-controlled trials.
This study was a meta-analysis of randomized controlled trials (RCTs) of ranitidine as an adjunct for antipsychotic-induced weight gain in patients with schizophrenia. RCTs reporting weight gain or metabolic side effects in patients with schizophrenia were included. Case reports/series, non-randomized or observational studies, reviews, and meta-analyses were excluded. The primary outcome measures were body mass index (BMI) (kg/m2) and body weight (kg). Four RCTs with five study arms were identified and analyzed. Compared with the control group, adjunctive ranitidine was associated with marginally significant reductions in BMI and body weight. After removing an outlier study for BMI, the effect of ranitidine remained significant. Adjunctive ranitidine outperformed the placebo in the negative symptom score of the Positive and Negative Syndrome Scale. Although ranitidine was associated with less frequent drowsiness, other adverse events were similar between the two groups. Adjunctive ranitidine appears to be an effective and safe option for reducing antipsychotic-induced weight gain and improving negative symptoms in patients with schizophrenia. Larger RCTs are warranted to confirm these findings. Trial registration PROSPERO: CRD42016039735.
['Gu|Xiao-Jing|XJ|', 'Chen|Rui|R|', 'Sun|Chen-Hui|CH|', 'Zheng|Wei|W|', 'Yang|Xin-Hu|XH|', 'Wang|Shi-Bin|SB|', 'Ungvari|Gabor S|GS|', 'Ng|Chee H|CH|', 'Golenkov|Andrei|A|', 'Lok|Grace K I|GKI|', 'Li|Lu|L|', 'Chow|Ines H I|IHI|', 'Wang|Fei|F|', 'Xiang|Yu-Tao|YT|']
D000328:Adult D014150:Antipsychotic Agents D015992:Body Mass Index D001835:Body Weight D005260:Female D006801:Humans D008297:Male D010919:Placebos D020011:Protective Agents D016032:Randomized Controlled Trials as Topic D011899:Ranitidine D012559:Schizophrenia D015430:Weight Gain
ranitidine weight gain meta-analysis Schizophrenia negative symptom antipsychotics