Serum concentrations of trace elements and their relationships with paraoxonase-1 in morbidly obese women.
The metabolic alterations associated with obesity include mineral dysregulation. Essential trace elements are nutrients with a relevant function in a large number of cellular processes and multiple roles in the correct functioning of metabolic enzymes. Paraoxonase-1 (PON1) is an antioxidant and anti-inflammatory enzyme that is compromised in obesity. In the present study, the potential alterations in trace elements in morbidly obese women were assessed in relation to serum PON1 activity and concentration, as well as to other obesity-related comorbidities such as diabetes mellitus and fatty liver. We recruited 41 morbidly obese women and 51 control individuals. The serum concentrations of 30 elements, PON1 paraoxonase and lactonase activities, and PON1 concentration were measured. We observed significant alterations in the levels of As, Ba, Cu, Ca, Fe, Mg, Na, Se, Sr, and Zn in obese women; some of them (As, Ca, Cr, Cu, Mg, and Se) being significantly correlated with serum PON1 values. The most relevant changes were observed in the concentrations of As, Sr and Mg, the last of which was also significantly associated with diabetes mellitus. The current results raise the possibility that increased ingestion and/or storage of a number of trace elements may be factors predisposing to obesity-related comorbidities and metabolic alterations.
['Luciano-Mateo|Fedra|F|', 'Cabré|Noemí|N|', 'Nadal|Martí|M|', 'García-Heredia|Anabel|A|', 'Baiges-Gaya|Gerard|G|', 'Hernández-Aguilera|Anna|A|', 'Camps|Jordi|J|', 'Joven|Jorge|J|', 'Domingo|José Luis|JL|']
D000328:Adult D043303:Aryldialkylphosphatase D005260:Female D006801:Humans D008875:Middle Aged D009767:Obesity, Morbid D014131:Trace Elements D055815:Young Adult
Trace elements Paraoxonase-1 Obesity Minerals Diabetes