Tenascin-C as a prognostic determinant of colorectal cancer through induction of epithelial-to-mesenchymal transition and proliferation.
Although Tenascin-C (TNC) as an extracellular matrix protein involved in various cancers, the mechanisms by which TNC leads to decreased survival time remain to be clarified in CRC. We assessed the expression of TNC and its relationship with cancer associated fibroblasts (CAFs) markers, epithelial-to-mesenchymal transition (EMT) and cell cycle markers in 100 paraffin-embedded CRC tissue samples using immunohistochemistry. TNC expression was higher in CRC tissue samples than in adjacent non-tumor-tissues (P < .001). In addition, TNC was involved in clinical stage (P = .030), pT stage (P = .049), distant metastasis (P = .004), tumor recurrence (P = .007), and tumor budding (P < .001). TNC play crucial roles in regulating the poor 5-year CRC survival rate by Kaplan-Meier analysis, and was an independent predictor of poor overall survival (P = .007) and disease-free survival (P = .004) in CRC. Moreover, it was postively correlated with CAF (SMA (P < .001) and FSP1 (P = .005)) and cell cycle marker p27 (P = .013) along with EMT (E-cadherin, P = .599; Snail, P < .001; vimentin, P = .012). TNC may promote EMT-like change and proliferation, which lead to poor prognosis for patients with CRC.
['Yang|Zhaoting|Z|', 'Zhang|Chengye|C|', 'Qi|Wenbo|W|', 'Cui|Chunai|C|', 'Cui|Yan|Y|', 'Xuan|Yanhua|Y|']
D000328:Adult D000368:Aged D014408:Biomarkers, Tumor D015820:Cadherins D049109:Cell Proliferation D002681:China D003110:Colonic Neoplasms D015179:Colorectal Neoplasms D018572:Disease-Free Survival D058750:Epithelial-Mesenchymal Transition D005109:Extracellular Matrix D016326:Extracellular Matrix Proteins D005260:Female D005347:Fibroblasts D006801:Humans D007150:Immunohistochemistry D053208:Kaplan-Meier Estimate D008207:Lymphatic Metastasis D008297:Male D008875:Middle Aged D009364:Neoplasm Recurrence, Local D011379:Prognosis D019063:Tenascin
Tenascin-C Colorectal cancer Prognosis Epithelial mesenchymal transition