PMEPA1, a TGF-β- and hypoxia-inducible gene that participates in hypoxic gene expression networks in solid tumors.
Prostate transmembrane protein, androgen induced 1 (PMEPA1) is highly expressed in various solid tumors and is known to play important roles in the transforming growth factor-β (TGF-β) signaling pathway. Here, we demonstrate a novel relationship between PMEPA1 and hypoxia, a common microenvironmental stress condition in solid tumors. We showed that induction of PMEPA1 expression occurred during hypoxia in a manner dependent on both TGF-β signaling and hypoxia-inducible factor-1 (HIF-1) pathways. Furthermore, overexpression and knockdown experiments revealed that PMEPA1 enhanced HIF-1 transcription activity. Bioinformatics analyses of PMEPA1-correlated genes using a gene expression database in clinical settings showed significant enrichment of gene sets defined by TGF-β and hypoxia and these two signaling pathways-related angiogenesis and epithelial-mesenchymal transition in many types of solid tumors. Collectively, our findings indicated that PMEPA1 participates in TGF-β- and hypoxia-regulated gene expression networks in solid tumors and thereby may contribute to tumor progression.
['Koido|Masaru|M|', 'Sakurai|Junko|J|', 'Tsukahara|Satomi|S|', 'Tani|Yuri|Y|', 'Tomida|Akihiro|A|']
D045744:Cell Line, Tumor D015972:Gene Expression Regulation, Neoplastic D055785:Gene Knockdown Techniques D053263:Gene Regulatory Networks D006801:Humans D047908:Intracellular Signaling Peptides and Proteins D008565:Membrane Proteins D024101:Mitochondrial Proteins D009363:Neoplasm Proteins D009369:Neoplasms D014158:Transcription, Genetic D016212:Transforming Growth Factor beta D000072258:Tumor Hypoxia
PMEPA1 TGF-β Hypoxia