A significant productive in vivo infection of resting cells with simian immunodeficiency virus in a macaque with AIDS.
Identifying the cells that can be infected with HIV in vivo and thus potentially persist as latent reservoirs is of high priority. Here, we report the major infected cells in a chronically simian immunodeficiency virus (SIV)-infected macaque that developed AIDS and encephalitis. A majority of the infected cells were detected as non-proliferating resting cells. SIV-infected non-proliferating resting cells were found to be playing an important role in viral pathogenesis, persistence, or reservoir formation.
['Pahar|Bapi|B|', 'Lala|Wendy|W|', 'Kuebler|Dot|D|', 'Liu|David|D|']
D000818:Animals D003713:Dendritic Cells D004660:Encephalitis D008253:Macaca mulatta D008264:Macrophages D008297:Male D016097:Simian Acquired Immunodeficiency Syndrome D015302:Simian Immunodeficiency Virus D013601:T-Lymphocytes
infection resting cells simian immunodeficiency virus reservoir T cells macrophage simian immunodeficiency virus RNA