Neuronal rebound spiking, resonance frequency and theta cycle skipping may contribute to grid cell firing in medial entorhinal cortex.
Data show a relationship of cellular resonance and network oscillations in the entorhinal cortex to the spatial periodicity of grid cells. This paper presents a model that simulates the resonance and rebound spiking properties of entorhinal neurons to generate spatial periodicity dependent upon phasic input from medial septum. The model shows that a difference in spatial periodicity can result from a difference in neuronal resonance frequency that replicates data from several experiments. The model also demonstrates a functional role for the phenomenon of theta cycle skipping in the medial entorhinal cortex.
['Hasselmo|Michael E|ME|']
D000109:Acetylcholine D000200:Action Potentials D000818:Animals D003198:Computer Simulation D018728:Entorhinal Cortex D008959:Models, Neurological D009474:Neurons D013028:Space Perception D013826:Theta Rhythm
grid cells entorhinal cortex head direction place cells rat theta rhythm