Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain.
The abnormal expression and function of myelin-related proteins contribute to nervous system dysfunction associated with neuropsychiatric disorders; however, the underlying mechanism of this remains unclear. We found here that breast carcinoma amplified sequence 1 (BCAS1), a basic protein abundant in the brain, was expressed specifically in oligodendrocytes and Schwann cells, and that its expression level was decreased by demyelination. This suggests that BCAS1 is a novel myelin-associated protein. BCAS1 knockout mice displayed schizophrenia-like behavioral abnormalities and a tendency toward reduced anxiety-like behaviors. Moreover, we found that the loss of BCAS1 specifically induced hypomyelination and the expression of inflammation-related genes in the brain. These observations provide a novel insight into the functional link between oligodendrocytes and inflammation and/or abnormal behaviors.
['Ishimoto|Tetsuya|T|', 'Ninomiya|Kensuke|K|', 'Inoue|Ran|R|', 'Koike|Masato|M|', 'Uchiyama|Yasuo|Y|', 'Mori|Hisashi|H|0000-0001-9743-2456']
D000818:Animals D001921:Brain D003711:Demyelinating Diseases D007249:Inflammation D018345:Mice, Knockout D004676:Myelin Basic Protein D009186:Myelin Sheath D009363:Neoplasm Proteins D009836:Oligodendroglia D012559:Schizophrenia D015533:Transcriptional Activation D015854:Up-Regulation
hypomyelination oligodendrocyte Schwann cells knockout mouse schizophrenia