Genome-Wide Association Study of Body Mass Index and Body Fat in Mexican-Mestizo Children.
BACKGROUND
Childhood obesity is a major health problem in Mexico. Obesity prevalence estimated by body mass index (BMI) is almost half than that estimated by percent body fat (%BF) in the Childhood Obesity pediatric cohort (COIPIS).


OBJECTIVE
We performed a genome-wide association study (GWAS) of BMI and %BF in 828 children from the COIPIS to identify markers of predisposition to high values for both phenotypes used for obesity classification.


METHODS
For the GWAS we used the LAT Axiom 1, Affymetrix and 2.5 million single loci from the 1000 Genomes Phase 3 imputation panel. We used a linear model, adjusted by age, sex, and Amerindian ancestry assuming an additive inheritance model.


RESULTS
Genome-wide significance (p ≤ 5.0 × 10-8) and 80% of statistical power was reached for associations of two loci in two genes (CERS3 and CYP2E1) to BMI. Also, 11 loci in six genes (ANKS1B, ARNTL2, KCNS3, LMNB1, SRGAP3, TRPC7) reached genome-wide significance for associations to %BF, though not 80% of statistical power.


DISCUSSION
None of the SNPs were previously reported as being associated to BMI or %BF. In addition, different loci were found for BMI and %BF. These results highlight the importance of gaining deeper understanding of genetic markers of predisposition to high values for the phenotypes used for obesity diagnosis.
['Costa-Urrutia|Paula|P|', 'Colistro|Valentina|V|', 'Jiménez-Osorio|Angélica Saraí|AS|', 'Cárdenas-Hernández|Helios|H|', 'Solares-Tlapechco|Jacqueline|J|', 'Ramirez-Alcántara|Miryam|M|', 'Granados|Julio|J|', 'Ascencio-Montiel|Iván de Jesús|IJ|', 'Rodríguez-Arellano|Martha Eunice|ME|']
D050154:Adiposity D000293:Adolescent D015992:Body Mass Index D002648:Child D002675:Child, Preschool D005260:Female D056426:Genetic Loci D005819:Genetic Markers D055106:Genome-Wide Association Study D005838:Genotype D006801:Humans D008297:Male D008800:Mexico D063766:Pediatric Obesity D020641:Polymorphism, Single Nucleotide D015995:Prevalence
childhood BMI GWAS percent of body fat