Muscle Glycogen Phosphorylase and Its Functional Partners in Health and Disease.
Glycogen phosphorylase (PG) is a key enzyme taking part in the first step of glycogenolysis. Muscle glycogen phosphorylase (PYGM) differs from other PG isoforms in expression pattern and biochemical properties. The main role of PYGM is providing sufficient energy for muscle contraction. However, it is expressed in tissues other than muscle, such as the brain, lymphoid tissues, and blood. PYGM is important not only in glycogen metabolism, but also in such diverse processes as the insulin and glucagon signaling pathway, insulin resistance, necroptosis, immune response, and phototransduction. PYGM is implicated in several pathological states, such as muscle glycogen phosphorylase deficiency (McArdle disease), schizophrenia, and cancer. Here we attempt to analyze the available data regarding the protein partners of PYGM to shed light on its possible interactions and functions. We also underline the potential for zebrafish to become a convenient and applicable model to study PYGM functions, especially because of its unique features that can complement data obtained from other approaches.
['Migocka-Patrzałek|Marta|M|0000-0003-0077-7779', 'Elias|Magdalena|M|']
D000818:Animals D004195:Disease Models, Animal D005786:Gene Expression Regulation D006003:Glycogen D024981:Glycogen Phosphorylase D006012:Glycogen Storage Disease Type V D006801:Humans D007333:Insulin Resistance D055537:Light Signal Transduction D009119:Muscle Contraction D018482:Muscle, Skeletal D000079302:Necroptosis D009369:Neoplasms D025941:Protein Interaction Mapping D055213:Retinal Pigment Epithelium D012559:Schizophrenia D015027:Zebrafish
muscle glycogen phosphorylase glycogenolysis PYGM McArdle disease schizophrenia cancer functional protein partners