Time-Varying Insomnia Symptoms and Incidence of Cognitive Impairment and Dementia among Older US Adults.
There is conflicting evidence regarding the association between insomnia and the onset of mild cognitive impairment (MCI) or dementia. This study aimed to evaluate if time-varying insomnia is associated with the development of MCI and dementia. Data from the Health and Retirement Study (n = 13,833) from 2002 to 2014 were used (59.4% female). The Brief Insomnia Questionnaire was used to identify insomnia symptoms which were compiled in an insomnia severity index, ranging from 0 to 4. In analysis, participants' symptoms could vary from wave-to-wave. Dementia was defined using results from the Health and Retirement Study (HRS) global cognitive assessment tool. Respondents were classified as either having dementia, MCI, or being cognitively healthy. Cox proportional hazards models with time-dependent exposure using the counting process (start-stop time) were used for analysis. For each one-unit increase in the insomnia symptom index, there was a 5-percent greater hazard of MCI (HR = 1.05; 95% CI: 1.04-1.06) and dementia (HR = 1.05; 95% CI: 1.03-1.05), after fully adjusting. Using a nationally representative sample of adults age 51 and older, this study found that time-varying insomnia symptoms are associated with risk of MCI and dementia. This highlights the importance of identifying sleep disturbances and their change over time as potentially important risk factors for MCI and dementia.
['Resciniti|Nicholas V|NV|', 'Yelverton|Valerie|V|0000-0002-9445-7022', 'Kase|Bezawit E|BE|', 'Zhang|Jiajia|J|', 'Lohman|Matthew C|MC|0000-0002-2273-2160']
D000368:Aged D060825:Cognitive Dysfunction D003704:Dementia D005260:Female D006801:Humans D015994:Incidence D008297:Male D008875:Middle Aged D009483:Neuropsychological Tests D012307:Risk Factors D007319:Sleep Initiation and Maintenance Disorders D014481:United States
time-varying insomnia cognitive impairment dementia sleep older adults