Functional BCL-2 rs2279115 Promoter Noncoding Variant Contributes to Glioma Predisposition, Especially in Males.
As a crucial oncogene, B cell lymphoma-2 (BCL-2) could promote cancer cell survival by inhibiting apoptosis via suppressing activation of proapoptotic proteins, such as BAX and BAK. There is a functional rs2279115 genetic polymorphism locating in BCL-2 promoter and deregulating BCL-2 expression. However, it is still largely undefined how BCL-2 rs2279115 promoter noncoding genetic variant is involved in glioma development. We examined the association between BCL-2 rs2279115 and glioma risk using a case-control approach. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by logistic regression adjusted by age and sex. Our results demonstrated that BCL-2 rs2279115 was significantly associated with glioma risk. The odd of individuals harboring A allele (CA + AA genotype) was 0.50 (95% CI = 0.39-0.64, p = 1.0 × 10-7) compared with CC genotype carriers. Stratification analyses by sex elucidated that BCL-2 rs2279115 was significantly associated with glioma risk in males (OR = 0.41, 95% CI = 0.30-0.58, p = 1.0 × 10-7), but not in females (p > 0.05). In summary, our results indicate that the functional BCL-2 rs2279115 genetic variant contributes to glioma predisposition and suggest prevalent involvement of regulatory genetic variations in glioma development.
['Qiu|Xiao-Guang|XG|', 'Chen|Yi-Dong|YD|', 'Yuan|Jupeng|J|', 'Zhang|Nasha|N|', 'Lei|Tianshui|T|', 'Liu|Jie|J|', 'Yang|Ming|M|']
D000368:Aged D000483:Alleles D044466:Asians D016022:Case-Control Studies D005260:Female D019254:Genes, bcl-2 D020022:Genetic Predisposition to Disease D005838:Genotype D005910:Glioma D006801:Humans D008297:Male D008875:Middle Aged D020641:Polymorphism, Single Nucleotide D011401:Promoter Regions, Genetic D012307:Risk Factors
BCL-2 glioma genetic polymorphism Chinese susceptibility