Metabolic syndrome in children with chronic kidney disease: PON1 and treatment modality.
BACKGROUND AND AIMS
We undertook this study to evaluate the relationship between PON1, SOD and metabolic syndrome (MetS) in pediatric patients undergoing peritoneal dialysis, hemodialysis and patients in early stages of CKD.


METHODS
We carried out an analytical cross-sectional study of 134 children 6-17 years old. We registered anthropometric variables, vital signs, basic biochemical parameters, intact PTH (iPTH), high sensitivity CRP (hs-CRP), paraoxonase-1; SOD; PON1/HDL-cholesterol and homocysteine. For statistical analyses we used t test, Mann Whitney U test, χ(2), Fisher exact test, linear or logistic regression models, using SPSS v.16.0. p values <0.05 were considered as significant.


RESULTS
There were 66 (49.3%) females; 39 (29.1%) had CKD stages 2-4 (predialysis), 42 (31.3%) on hemodialysis (HD) and 53 (39.6%) on automated peritoneal dialysis (PD). Time from diagnosis was 26 months. Significant differences were observed in mean, systolic and diastolic blood pressure, C-peptide, triglycerides, and HDL-cholesterol as well as PON1/HDL-cholesterol ratio and SOD.


CONCLUSIONS
This study demonstrates that PON1 and SOD may be predictors for the presence of MetS in pediatric patients under treatment with peritoneal dialysis. The positive correlation observed in PON1/HDL-cholesterol ratio may reflect the protector effect of HDL-cholesterol in patients with CKD according with the modality of treatment.
['Gómez-Díaz|Rita A|RA|', 'García-Bello|Juan Antonio|JA|', 'Mondragón-González|Rafael|R|', 'Díaz-Flores|Margarita|M|', 'Valladares-Salgado|Adán|A|', 'Gallardo|Juan Manuel|JM|', 'Talavera|Juan O|JO|', 'Wacher|Niels H|NH|']
D000293:Adolescent D043303:Aryldialkylphosphatase D002648:Child D002675:Child, Preschool D008076:Cholesterol, HDL D003430:Cross-Sectional Studies D042241:Early Diagnosis D005260:Female D006801:Humans D007676:Kidney Failure, Chronic D008297:Male D024821:Metabolic Syndrome D010530:Peritoneal Dialysis D006435:Renal Dialysis D051436:Renal Insufficiency, Chronic D013482:Superoxide Dismutase D016896:Treatment Outcome
Metabolic syndrome in children SOD Paraoxonase-1 PON1/HDL-cholesterol CKD treatment modality