Metabolite of tryptophan promoting changes in EEG signal and the oxidative status of the brain.
Tryptophan is an essential amino acid precursor of neurotransmitter serotonin and triptamine. During its metabolism, indole-3-acetic acid (IAA) is generated; this substance presents both antioxidant and prooxidant effects in different biological systems in addition to hipoglicemic effects. To date, electroencephalography (EEG) has been used to evaluate the temporal effect of several substances in neurotransmission. The goal of this study was to characterize the effect of IAA in the brain by analysing the EEG signal and evaluate the oxidative status by means of biochemical parameters. The EEG was acquired by using a noninvasive method, and the brain electric signal was analysed by advanced digital signal processing techniques to determinate the energy signal filtered in different band frequencies. Furthermore, the oxidative status of the brain was investigated by measuring the activity of antioxidant enzymes and lipid peroxidation as well as blood glucose rates of the animals treated with different doses of IAA. Our results showed the relationship of IAA administration with changes in EEG signals. The oxidative status of the brain was modified by IAA after 14 days of treatment.
['Ferrari|Rosana|R|', 'Pugini|Silvana Maria Picolli|SM|', 'Arce|Aldo Ivan Cespedes|AI|', 'Costa|Ernane Jose Xavier|EJ|', 'de Melo|Mariza Pires|MP|']
D000818:Animals D001786:Blood Glucose D001921:Brain D002374:Catalase D004569:Electroencephalography D005980:Glutathione Reductase D007210:Indoleacetic Acids D015227:Lipid Peroxidation D008297:Male D008315:Malondialdehyde D010084:Oxidation-Reduction D017208:Rats, Wistar D013482:Superoxide Dismutase D014364:Tryptophan
IAA neurotransmission SOD brain electrical activity oxidative stress