Lung squamous cell carcinoma with severe hypomagnesemia due to cisplatin plus gemcitabine in combination with necitumumab therapy: A case report.
A 72-year-old man, diagnosed with advanced lung squamous cell carcinoma, was administered of cisplatin plus gemcitabine with necitumumab, a human monoclonal antibody that binds to the epidermal growth factor receptor (EGFR), as a sixth-line treatment. Tumor shrinkage was observed, but asymptomatic grade 4 hypomagnesemia occurred on day 8 of the second cycle. He received magnesium replenishment and hypomagnesemia recovered on day 40, but tumor progression was observed during the period of magnesium correction. Hypomagnesemia is known as a major adverse event of treatment with anti-EGFR antibodies, but there have been no case reports of severe hypomagnesemia or its clinical course.
['Nakao|Akira|A|0000-0001-8308-4227', 'Inoue|Hiroyuki|H|', 'Osaki|Yusuke|Y|', 'Hirano|Ryosuke|R|', 'Harada|Taishi|T|', 'Aoyama|Takashi|T|', 'Igata|Fumiyasu|F|', 'Fujita|Masaki|M|']
hypomagnesemia cisplatin gemcitabine necitumumab squamous cell lung cancer