Metastatic breast carcinoma to the urinary bladder-a report of 11 cases including a tumor to tumor metastasis.
Metastatic breast carcinoma to the urinary bladder is rare. Eleven cases of metastatic breast carcinoma to the bladder are described in this report, including one case with a tumor to tumor metastasis. The patients ranged from 51 to 83 years of age. The time intervals between the diagnosis of primary breast cancer and the occurrence of bladder metastases ranged from 41 to 336 months. There were seven cases of invasive ductal carcinoma and four cases of invasive lobular carcinoma. In one case, a lobular carcinoma of the breast metastasized to a concurrent squamous cell carcinoma of the bladder. The immunophenotypic status of estrogen receptor and Her2 expression of the metastatic carcinomas were all concordant with the primary tumors. In nine patients with follow-up available, seven patients died of the disease ranging from 1 to 23 months after the diagnosis of the bladder metastasis and two patients were alive at 5 months of follow-up. To date, this report is the largest single series of patients with breast carcinoma metastatic to the bladder. It is the first reported instance of lobular carcinoma of the breast metastasizing to a squamous cell carcinoma of the bladder.
['Wang|Gang|G|http://orcid.org/0000-0002-0225-4173', 'Zhou|Chen|C|', 'Conklin|Christopher|C|', 'Hayes|Malcolm M|MM|', 'Villamil|Carlos F|CF|', 'Ostry|Avrum|A|', 'Jones|Edward C|EC|']
D000368:Aged D000369:Aged, 80 and over D014408:Biomarkers, Tumor D001706:Biopsy D001943:Breast Neoplasms D018270:Carcinoma, Ductal, Breast D018275:Carcinoma, Lobular D002294:Carcinoma, Squamous Cell D005260:Female D006801:Humans D007150:Immunohistochemistry D008875:Middle Aged D011379:Prognosis D018719:Receptor, ErbB-2 D011960:Receptors, Estrogen D013997:Time Factors D001749:Urinary Bladder Neoplasms
Breast carcinoma Tumor to tumor metastasis Metastasis Bladder