Comparison of Mean Platelet Counts in Preterm Infants with and without Retinopathy of Prematurity.
Platelets are a primary source of pro- and anti-angiogenic cytokines. However, the evidence of their role in retinopathy of prematurity (ROP) is controversial. This retrospective study aimed to compare mean weekly platelet counts between infants with and without ROP over the first 6 weeks of life. A total of 93 infants matched by gestational age and birth weight were recruited (31 with ROP, 62 without ROP). Weekly mean platelet counts and other related risk factors were documented. The repeated measure analysis of variance (ANOVA) and the repeated measure analysis of covariance (ANCOVA) were used to compare mean platelet counts over time between the two groups, with and without adjusting for confounders. We found significant differences in the weekly mean platelet counts of infants with and without ROP over the first 6 weeks of life (p = 0.002). These differences disappeared after adjusting for covariates (p = 0.489). Lower mean platelet counts in ROP infants are not directly related to ROP, but rather to the presence of other risk factors for ROP, such as culture-proven sepsis, blood transfusion and bronchopulmonary dysplasia.
['Lim|Zi Di|ZD|', 'Pheng|Edwin|E|', 'Min|Evelyn Tai Li|ETL|0000-0001-8055-5396', 'Van Rostenberghe|Hans|H|', 'Shatriah|Ismail|I|0000-0002-4753-4814']
D001724:Birth Weight D005865:Gestational Age D006801:Humans D007223:Infant D007230:Infant, Low Birth Weight D007231:Infant, Newborn D007234:Infant, Premature D010976:Platelet Count D012178:Retinopathy of Prematurity D012189:Retrospective Studies D012307:Risk Factors
platelet count infant retinopathy of prematurity premature