hMENA(11a), a hMENA isoform sending survival signals.
Human MENA(11a) (hMENA(11a)), an epithelial-associated isoform of the actin binding protein enabled homolog (ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1, HER2, and HER3. Here, we reveal a novel role of this isoform in sustaining cell survival and propose hMENA(11a) as a marker of HER3 activation and resistance to phosphatidylinositol-3-kinase inhibition therapies.
['Trono|Paola|P|', 'Di Modugno|Francesca|F|', 'Nisticò|Paola|P|']
HER3 Breast cancer PI3K oncogenic signaling therapy resistance