The Microbiota of the Extremely Preterm Infant.
Colonization of the extremely preterm infant's gastrointestinal tract and skin begins in utero and is influenced by a variety of factors, the most important including gestational age and environmental exposures. The composition of the intestinal and skin microbiota influences the developing innate and adaptive immune responses with short-term and long-term consequences including altered risks for developing necrotizing enterocolitis, sepsis, and a wide variety of microbe-related diseases of children and adults. Alteration of the composition of the microbiota to decrease disease risk is particularly appealing for this ultra-high-risk cohort that is brand new from an evolutionary standpoint.
['Underwood|Mark A|MA|', 'Sohn|Kristin|K|']
D000900:Anti-Bacterial Agents D064806:Dysbiosis D020345:Enterocolitis, Necrotizing D000069196:Gastrointestinal Microbiome D006801:Humans D062071:Infant, Extremely Premature D007231:Infant, Newborn D064307:Microbiota D009055:Mouth D000071074:Neonatal Sepsis D056692:Prebiotics D019936:Probiotics D012867:Skin
Microbiota Skin Necrotizing enterocolitis Dysbiosis Intestinal tract Late-onset sepsis Oral cavity