Treatment of Oxidative Stress with Exosomes in Myocardial Ischemia.
A thrombus in a coronary artery causes ischemia, which eventually leads to myocardial infarction (MI) if not removed. However, removal generates reactive oxygen species (ROS), which causes ischemia-reperfusion (I/R) injury that damages the tissue and exacerbates the resulting MI. The mechanism of I/R injury is currently extensively understood. However, supplementation of exogenous antioxidants is ineffective against oxidative stress (OS). Enhancing the ability of endogenous antioxidants may be a more effective way to treat OS, and exosomes may play a role as targeted carriers. Exosomes are nanosized vesicles wrapped in biofilms which contain various complex RNAs and proteins. They are important intermediate carriers of intercellular communication and material exchange. In recent years, diagnosis and treatment with exosomes in cardiovascular diseases have gained considerable attention. Herein, we review the new findings of exosomes in the regulation of OS in coronary heart disease, discuss the possibility of exosomes as carriers for the targeted regulation of endogenous ROS generation, and compare the advantages of exosome therapy with those of stem-cell therapy. Finally, we explore several miRNAs found in exosomes against OS.
['Liu|Yun|Y|', 'Wang|Mengxue|M|', 'Liang|Yin|Y|', 'Wang|Chen|C|', 'Naruse|Keiji|K|', 'Takahashi|Ken|K|0000-0002-7580-8691']
D000818:Animals D002986:Clinical Trials as Topic D003327:Coronary Disease D004195:Disease Models, Animal D004337:Drug Carriers D055354:Exosomes D005786:Gene Expression Regulation D006801:Humans D035683:MicroRNAs D015428:Myocardial Reperfusion Injury D018384:Oxidative Stress D017382:Reactive Oxygen Species D016896:Treatment Outcome
oxidative stress exosome myocardial infarction coronary heart disease exosome therapy reactive oxygen radicals