Preoperative predictors for outcomes after total hip replacement in patients with osteoarthritis: a systematic review.
BACKGROUND
This systematic review examines which patient related factors influence functional and clinical outcomes after total hip arthroplasty (THA) in patients with hip osteoarthritis (OA).


METHODS
We performed a systematic review according to the PRISMA guidelines. We searched databases and trial registries for prospective studies including OA patients who underwent primary THA. Studies with preoperative measurements on predictors, with at least 1 year follow-up were included. Risk of bias and confounding was assessed for two domains: follow-up rate and looking at independent effects.


RESULTS
Thirty-five studies were included (138,039 patients). Only nine studies (29 %) had low risk of bias for all domains thus suggesting an overall low quality of evidence. Studies were heterogeneous in the predictors tested and in the observed directions of the associations. Overall, preoperative function (13 studies (37 %), 2 with low risk of bias) and radiological OA (6 studies (17 %), 1 with low risk of bias) were predictors with the most consistent findings. Worse preoperative function and more severe radiological OA were associated with larger postoperative improvement. However, these patients never reached the level of postoperative functioning as patients with better preoperative function or less severe radiological OA. For age, gender, comorbidity, pain and quality of life the results of studies were conflicting. For BMI, some studies (n = 5, 2 with low risk of bias) found worse outcomes for patients with higher BMI. However, substantial improvement was still achieved regardless of their BMI.


CONCLUSION
There is not enough evidence to draw succinct conclusions on preoperative predictors for postoperative outcome in THA, as results of studies are conflicting and the methodological quality is low. Results suggest to focus on preoperative function and radiological osteoarthritis to decide when THA will be most effective. The present mapping of current evidence on the relationship between patient related factors and outcomes provides better information compared to individual studies and may help to set patient expectations before surgery. In addition, these findings may contribute to discussions on how to achieve the best possible postoperative outcome for specific patient groups.


TRIAL REGISTRATION
This systematic review was registered in Prospero, registration number RD42014009977 .
['Hofstede|Stefanie N|SN|', 'Gademan|Maaike G J|MG|', 'Vliet Vlieland|Thea P M|TP|', 'Nelissen|Rob G H H|RG|', 'Marang-van de Mheen|Perla J|PJ|']
D000367:Age Factors D000368:Aged D000369:Aged, 80 and over D019644:Arthroplasty, Replacement, Hip D015992:Body Mass Index D005260:Female D006801:Humans D008297:Male D015207:Osteoarthritis, Hip D010146:Pain D011184:Postoperative Period D057234:Preoperative Period D011788:Quality of Life D011859:Radiography D012737:Sex Factors D016896:Treatment Outcome
Predictors Outcome Osteoarthritis Review Hip arthroplasty