Predictive effect of GIPR SNP rs10423928 on glucose metabolism liver fat and adiposity in prediabetic and diabetic subjects.
The gastric inhibitory polypeptide receptor (GIPR) regulates postprandial metabolism. In this context GIPR SNP rs10423928 seems toplay an important role in modulating glucose metabolism and insulinsensitivity. However, evidence regarding thisparticular SNP is still vague. In this study, we collected baseline data from four different dietaryintervention studies. We genotyped 424 subjects with prediabetes and 73with diabetes for GIPR SNP rs10423928 and examined its impact on glucosemetabolism, insulin sensitivity and body fat accumulation. We extended previous data by showing that carriers of the A allele withprediabetes displayed increased fasting glucose (p = 0.015). Unexpectedly,A allele carriers showed lower glucose levels 2 h (p = 0.021) after anoral glucose challenge compared to T/T homozygous individuals. A allelecarriers also showed significantly higher insulin sensitivity (p < 0.001)(assessed by Cederholm Index), indicating an enhanced ß-cell response. This study points to a potential protective role for rs10423928 inglucose metabolism and insulin sensitivity in subjects with prediabetes.Further studies are necessary to confirm these results.
['Barbosa-Yañez|Renate Luzía|RL|', 'Markova|Mariya|M|', 'Dambeck|Ulrike|U|', 'Honsek|Caroline|C|', 'Machann|Jürgen|J|', 'Schüler|Rita|R|', 'Kabisch|Stefan|S|', 'Pfeiffer|Andreas F H|AFH|']
D050154:Adiposity D000328:Adult D000368:Aged D000369:Aged, 80 and over D000483:Alleles D015415:Biomarkers D003430:Cross-Sectional Studies D003924:Diabetes Mellitus, Type 2 D005234:Fatty Liver D005260:Female D005947:Glucose D006801:Humans D008297:Male D008875:Middle Aged D020641:Polymorphism, Single Nucleotide D011236:Prediabetic State D011237:Predictive Value of Tests D011964:Receptors, Gastrointestinal Hormone
GIPR Glucose metabolism Prediabetes Diabetes Insulin sensitivity Glucose-dependent insulinotropic peptide