Molecular Mechanism of Cannabinoids in Cancer Progression.
Cannabinoids are a family of heterogeneous compounds that mostly interact with receptors eliciting several physiological effects both in the central and peripheral nervous systems and in peripheral organs. They exert anticancer action by modulating signaling pathways involved in cancer progression; furthermore, the effects induced by their use depend on both the type of tumor and their action on the components of the endocannabinoid system. This review will explore the mechanism of action of the cannabinoids in signaling pathways involved in cancer proliferation, neovascularisation, migration, invasion, metastasis, and tumor angiogenesis.
['Pagano|Cristina|C|', 'Navarra|Giovanna|G|', 'Coppola|Laura|L|', 'Bifulco|Maurizio|M|', 'Laezza|Chiara|C|']
D000818:Animals D002186:Cannabinoids D018450:Disease Progression D063388:Endocannabinoids D006801:Humans D008024:Ligands D009369:Neoplasms D015398:Signal Transduction
cannabinoids cancer migration angiogenesis cell death