Outcomes of Patients With Hypothyroidism and COVID-19: A Retrospective Cohort Study.
Coronavirus diseases (COVID-19) is associated with high rates of morbidity and mortality and worse outcomes have been reported for various morbidities. The impact of pre-existing hypothyroidism on COVID-19 outcomes remains unknown. The aim of the present study was to identify a possible association between hypothyroidism and outcomes related to COVID-19 including hospitalization, need for mechanical ventilation, and all-cause mortality. All patients with a laboratory confirmed COVID-19 diagnosis in March 2020 in a large New York City health system were reviewed. Of the 3703 COVID-19 positive patients included in present study, 251 patients (6.8%) had pre-existing hypothyroidism and received thyroid hormone therapy. Hypothyroidism was not associated with increased risk of hospitalization [Adjusted Odds Ratio (ORadj): 1.23 (95% Confidence Interval (CI): 0.88- 1.70)], mechanical ventilation [ORadj: 1.17 (95% CI: 0.81-1.69)] nor death [ORadj: 1.07 (95% CI: 0.75-1.54)]. This study provides insight into the role of hypothyroidism on the outcomes of COVID-19 positive patients, indicating that no additional precautions or consultations are needed. However, future research into the potential complications of COVID-19 on the thyroid gland and function is warranted.
['van Gerwen|Maaike|M|', 'Alsen|Mathilda|M|', 'Little|Christine|C|', 'Barlow|Joshua|J|', 'Naymagon|Leonard|L|', 'Tremblay|Douglas|D|', 'Sinclair|Catherine F|CF|', 'Genden|Eric|E|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D000086382:COVID-19 D015331:Cohort Studies D018352:Coronavirus Infections D005260:Female D006760:Hospitalization D006801:Humans D007037:Hypothyroidism D008297:Male D008875:Middle Aged D009519:New York City D058873:Pandemics D011024:Pneumonia, Viral D012121:Respiration, Artificial D012189:Retrospective Studies D012306:Risk D013963:Thyroid Hormones D016896:Treatment Outcome
outcomes hypothyroidism COVID-19 cohort epidemiology survival