Oncologic outcomes of extended neck dissections in human papillomavirus-related oropharyngeal squamous cell carcinoma.
BACKGROUND
Oncologic outcomes of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) requiring resection of major muscular or neurovascular tissue during neck dissection for invasive nodal disease remain uncertain.


METHODS
Patients with HPV-related oropharyngeal SCC requiring resection of major muscular or neurovascular tissue during their neck dissections were retrospectively identified.


RESULTS
Seventy-two patients were included. Regional and distant recurrences occurred in 6% and 17% of patients. Advanced T classification, pathological node number of 5 or more, and omission of adjuvant therapy were associated with decreased disease-free survival (DFS). The addition of adjuvant chemotherapy was not associated with improved survival.


CONCLUSION
Patients with invasive nodal disease from HPV-related oropharyngeal SCC can be managed with up-front surgery and adjuvant therapy, as indicated with good regional control. Although distant recurrence was the primary site of failure, adjuvant chemotherapy was not associated with improved outcomes. The T classification, node number, and adjuvant radiotherapy are independent prognostic factors in this patient population.
['Zenga|Joseph|J|0000-0003-1565-9628', 'Pipkorn|Patrik|P|', 'Graboyes|Evan M|EM|0000-0003-3766-468X', 'Martin|Eliot J|EJ|', 'Rich|Jason T|JT|', 'Moore|Eric J|EJ|0000-0003-1103-6212', 'Haughey|Bruce H|BH|', 'Jackson|Ryan S|RS|']
D000368:Aged D002294:Carcinoma, Squamous Cell D003131:Combined Modality Therapy D018572:Disease-Free Survival D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D037981:Neck Dissection D009959:Oropharyngeal Neoplasms D027383:Papillomaviridae D030361:Papillomavirus Infections D012189:Retrospective Studies D015996:Survival Rate D016896:Treatment Outcome
oncologic outcomes neck dissection human papillomavirus extralymphatic oropharynx