Intracranial Arterial Fenestration and Risk of Aneurysm: A Systematic Review and Meta-Analysis.
BACKGROUND
Previous studies have been inconsistent regarding risk for intracranial aneurysm related to intracranial arterial fenestration. We conducted a meta-analysis to examine the association between intracranial arterial fenestration and risk of aneurysm.


METHODS
We performed a systematic review of PubMed and Embase through August 2017 for potentially relevant articles. Summary odds ratios with 95% confidence intervals were pooled using a random-effects model.


RESULTS
Of 446 articles found, 7 were selected for meta-analysis. Pooled odds ratios revealed an increased risk of aneurysm owing to fenestration of 1.50 (95% confidence interval, 0.61-3.71; P = 0.38). Subgroup analyses based on the population presenting with various indications suggested that pooled odds ratios indicated a significant increase in risk for aneurysm of 2.43 (95% confidence interval, 1.04-5.69; P = 0.04).


CONCLUSIONS
Our findings indicate that intracranial arterial fenestration may be associated with increased risk for aneurysm formation.
['Guo|Xiang|X|', 'Gao|Lingyun|L|', 'Shi|Zhitao|Z|', 'Liu|Deguo|D|', 'Wang|Yuhong|Y|', 'Sun|Zhanguo|Z|', 'Chen|Yueqin|Y|', 'Chen|Weijian|W|', 'Yang|Yunjun|Y|']
D020785:Central Nervous System Vascular Malformations D002533:Cerebral Angiography D006801:Humans D002532:Intracranial Aneurysm D012307:Risk Factors
Meta-analysis Intracranial aneurysm Angiography Central nervous system vascular malformations Spontaneous subarachnoid hemorrhage