Bone reconstruction in rat calvarial defects by chitosan/hydroxyapatite nanoparticles scaffold loaded with unrestricted somatic stem cells.
Calcium phosphates are one of the biomaterials that are used for bone regeneration. In this study, Hydroxyapatite (HAp) nanoparticles with chitosan gel filled with unrestricted somatic stem cells (USSCs) were used for healing calvarial bone in rat model. The healing effects of these injectable scaffolds with and without stem cells for bone regeneration were investigated by computed tomography (CT) analysis and pathology assays after 28 days of grafting. The results of CT analysis showing bone regeneration on the scaffolds, also the amounts of regenerated new bone for USSC scaffold was significantly greater than the scaffold without cell and untreated controls. Therefore, the combination of scaffold especially with USSC is considered as a useful method for bone regeneration.
['Biazar|Esmaeil|E|', 'Heidari Keshel|Saeed|S|', 'Tavirani|Mostafa Rezaei|MR|', 'Jahandideh|Rahim|R|']
D053687:Adult Stem Cells D000469:Alkaline Phosphatase D000818:Animals D001672:Biocompatible Materials D001861:Bone Regeneration D048271:Chitosan D017886:Durapatite D005260:Female D053758:Nanoparticles D051381:Rats D017208:Rats, Wistar D012886:Skull D054457:Tissue Scaffolds D014057:Tomography, X-Ray Computed
chitosan hydroxyapatite nanoparticles unrestricted somatic stem cells bone regeneration injectable scaffold