Endothelial-to-Mesenchymal Transition: Role in Cardiac Fibrosis.
Endothelial-to-mesenchymal transition (EndMT) is a complex biological process by which endothelial cells lose their endothelial cell characteristics and acquire mesenchymal cell properties under certain physiological or pathological conditions. Recently, it has been found that EndMT plays an important role in the occurrence and development of fibrotic cardiovascular diseases. In this review, we first summarize the main induction pathways involved in EndMT process. In addition, we discuss the role of EndMT in fibrotic cardiovascular diseases and its potential implication in new therapeutic interventions.
['Cheng|Weijia|W|', 'Li|Xiao|X|', 'Liu|Dongling|D|', 'Cui|Chaochu|C|0000-0003-0907-9766', 'Wang|Xianwei|X|0000-0002-1490-8736']
D000818:Animals D042783:Endothelial Cells D058750:Epithelial-Mesenchymal Transition D005355:Fibrosis D006331:Heart Diseases D006801:Humans D009206:Myocardium D015398:Signal Transduction
endothelial-to-mesenchymal transition cardiac fibrosis cardiovascular diseases TGF-β signaling microRNAs oxidative stress