Circular RNA as An Epigenetic Regulator in Chronic Liver Diseases.
Circular RNA (circRNA) is a type of non-coding RNA characterized by a covalently closed continuous loop. CircRNA is generated by pre-mRNA through back-splicing and is probably cleared up by extracellular vesicles. CircRNAs play a pivotal role in the epigenetic regulation of gene expression at transcriptional and post-transcriptional levels. Recently, circRNAs have been demonstrated to be involved in the regulation of liver homeostasis and diseases. However, the epigenetic role and underlying mechanisms of circRNAs in chronic liver diseases remain unclear. This review discussed the role of circRNAs in non-neoplastic chronic liver diseases, including alcoholic liver disease (ALD), metabolic-associated fatty liver disease (MAFLD), viral hepatitis, liver injury and regeneration, liver cirrhosis, and autoimmune liver disease. The review also highlighted that further efforts are urgently needed to develop circRNAs as novel diagnostics and therapeutics for chronic liver diseases.
['Zeng|Xianhui|X|0000-0002-2865-7560', 'Yuan|Xianglei|X|', 'Cai|Qiuyu|Q|', 'Tang|Chengwei|C|', 'Gao|Jinhang|J|']
D000818:Animals D015551:Autoimmunity D002908:Chronic Disease D044127:Epigenesis, Genetic D006801:Humans D008099:Liver D008107:Liver Diseases D008115:Liver Regeneration D000079962:RNA, Circular D015398:Signal Transduction
circular RNA epigenetics alcoholic liver disease metabolic-associated fatty liver disease hepatitis liver cirrhosis autoimmune liver disease liver regeneration nonalcoholic fatty liver disease nonalcoholic steatohepatitis