Hepatocyte growth factor: A regulator of inflammation and autoimmunity.
Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases. HGF was reported to prevent and attenuate disease progression by influencing multiple pathophysiological processes involved in inflammatory and immune response, including cell migration, maturation, cytokine production, antigen presentation, and T cell effector function. In this review, we discuss the actions and mechanisms of HGF in inflammation and immunity and the therapeutic potential of this factor for the treatment of inflammatory and autoimmune diseases.
['Molnarfi|Nicolas|N|', 'Benkhoucha|Mahdia|M|', 'Funakoshi|Hiroshi|H|', 'Nakamura|Toshikazu|T|', 'Lalive|Patrice H|PH|']
D000818:Animals D015551:Autoimmunity D017228:Hepatocyte Growth Factor D006801:Humans D007249:Inflammation D015398:Signal Transduction
Inflammation Autoimmunity HGF Autoimmune regulator Therapy c-Met