Synthesis and antiviral evaluation of fluorinated acyclo-nucleosides and their phosphoramidates.
A novel series of tetrafluoro and hexafluoro acyclic nucleosides and their phosphoramidates were successfully prepared from commercially available 2,2,3,3-tetrafluoro-1,4-butanediol and 2,2,3,3,4,4-hexafluoro-1,5-pentanediol in four to six steps. Their ability to block HIV, HCV, HSV-1, and HBV replication along with their cytotoxicity toward HepG2, human lymphocyte, CEM, and Vero cells was assessed.
['Mahmoud|Sawsan|S|', 'Li|Hao|H|', 'McBrayer|Tamara R|TR|', 'Bassit|Leda|L|', 'Hammad|Sherif F|SF|', 'Coats|Steven J|SJ|', 'Amblard|Franck|F|', 'Schinazi|Raymond F|RF|']
D000577:Amides D000818:Animals D019380:Anti-HIV Agents D000998:Antiviral Agents D060326:Chemistry Techniques, Synthetic D004353:Drug Evaluation, Preclinical D005461:Fluorine D056945:Hep G2 Cells D006515:Hepatitis B virus D018259:Herpesvirus 1, Human D006801:Humans D015394:Molecular Structure D009705:Nucleosides D010756:Phosphoric Acids D014709:Vero Cells D014779:Virus Replication
Fluorine phosphoramidates acyclonucleoside antiviral agent