Routine Early Antibiotic Use in SymptOmatic Preterm Neonates: A Pilot Randomized Controlled Trial.
We enrolled 98 infants (gestational age <33 weeks) in a pilot randomized trial of antibiotics vs no antibiotics; 55 were randomized (lower maternal infectious risk; symptoms expected for gestation). Adverse events did not differ significantly between the randomization arms. This trial establishes a framework for a larger multicentered trial.
['Ruoss|J Lauren|JL|', 'Bazacliu|Catalina|C|', 'Russell|Jordan T|JT|', 'Cruz|Diomel de la|D|', 'Li|Nan|N|', 'Gurka|Matthew J|MJ|', 'Filipp|Stephanie L|SL|', 'Polin|Richard A|RA|', 'Triplett|Eric W|EW|', 'Neu|Josef|J|']
D000367:Age Factors D000900:Anti-Bacterial Agents D005260:Female D006801:Humans D007231:Infant, Newborn D007234:Infant, Premature D008297:Male D010865:Pilot Projects D013290:Streptococcal Infections D013292:Streptococcus agalactiae
infants dysbiosis microbiome sepsis