Hepatitis E and neuralgic amyotrophy: Five cases and review of literature.
Hepatitis E virus infection - mainly genotype 3 - is increasingly common in industrialized countries. Infection is usually asymptomatic, but cases of central or peripheral neurological symptoms with hepatitis E have been described. The most frequent is Guillain-Barre but somes cases of neuralgic amyotrophy have been described. In our center, since 2010, we have identified five cases of neuralgic amyotrophy associated with acute hepatitis E in immunocompetent patients. For all these patients, neuralgic amyotrophy was diagnosed with electromyogram and positive IgM for hepatitis E, and detectable HEV RNA in 4 of the cases. Including our patients, we count 26 cases in literature. The mean age of the patients was 44 years old, with a large predominance of males (88%). The disorder is bilateral and asymmetric in 69% of cases. Peripheral nerves other than the brachial plexus were affected in 6 patients (23%). In industrialized countries, any neuralgic amyotrophy, particularly if there is bilateral, asymmetric associated with involvement of nerves outside the brachial plexus, should lead physicians to consider a diagnosis of acute hepatitis E.
['Dartevel|Anaïs|A|', 'Colombe|Barbara|B|', 'Bosseray|Annick|A|', 'Larrat|Sylvie|S|', 'Sarrot-Reynauld|Françoise|F|', 'Belbezier|Aude|A|', 'Lagrange|Emmeline|E|', 'Bouillet|Laurence|L|']
D000328:Adult D020968:Brachial Plexus Neuritis D019049:Developed Countries D005260:Female D016751:Hepatitis E D006801:Humans D007075:Immunoglobulin M D008297:Male D008875:Middle Aged D012737:Sex Factors
Neuralgic amyotrophy Nervous system diseases Parsonage turner syndrome Strong hepatitis E