Engineered Bio-inspired Multifunctional Peptide- and Protein-based Therapeutic Biomolecules for Better Wound Care.
Developing non-immunogenic therapeutic biomolecules for facilitating blood clotting followed by wound healing via therapeutic angiogenesis, still remains a formidable challenge. Excessive blood loss of accident victims and battalions cause a huge number of deaths worldwide. Patients with inherited bleeding disorders face acute complications during injury and post-surgery. Biologically-inspired peptide-based hemostat can act as a potential therapeutic for handling coagulopathy. Additionally, non-healing wounds for patients having ischemic diseases can cause severe clinical complications. Advancement in stabilized growth-factor-based proangiogenic therapy may offer effective possibilities for the treatment of ischemic pathology. This review will discuss nature-inspired biocompatible stabilized peptide- and protein-based molecular medicines to serve unmet medical challenges for handling traumatic coagulopathy and impaired wound healing.
['Gayen|Paramita|P|http://orcid.org/0000-0001-6329-0330', 'Jan|Somnath|S|http://orcid.org/0000-0002-4849-4455', 'Chowdhury|Nilkanta|N|http://orcid.org/0000-0002-9267-0524', 'Ghosh|Snehasish|S|http://orcid.org/0000-0003-0472-747X', 'Hembram|Monjuri|M|http://orcid.org/0000-0002-4226-2469', 'Bagchi|Angshuman|A|http://orcid.org/0000-0003-4611-4663', 'Sinha Roy|Rituparna|R|http://orcid.org/0000-0003-3450-1017']
wound healing blood-clotting growth factor mimetics peptide sealant