The role of oxidative and nitrosative stress in accelerated aging and major depressive disorder.
Major depressive disorder (MDD) affects millions of individuals and is highly comorbid with many age associated diseases such as diabetes mellitus, immune-inflammatory dysregulation and cardiovascular diseases. Oxidative/nitrosative stress plays a fundamental role in aging, as well as in the pathogenesis of neurodegenerative/neuropsychiatric disorders including MDD. In this review, we critically review the evidence for an involvement of oxidative/nitrosative stress in acceleration of aging process in MDD. There are evidence of the association between MDD and changes in molecular mechanisms involved in aging. There is a significant association between telomere length, enzymatic antioxidant activities (SOD, CAT, GPx), glutathione (GSH), lipid peroxidation (MDA), nuclear factor κB, inflammatory cytokines with MDD. Major depression also is characterized by significantly lower concentration of antioxidants (zinc, coenzyme Q10, PON1). Since, aging and MDD share a common biological base in their pathophysiology, the potential therapeutic use of antioxidants and anti-aging molecules in MDD could be promising.
['Maurya|Pawan Kumar|PK|', 'Noto|Cristiano|C|', 'Rizzo|Lucas B|LB|', 'Rios|Adiel C|AC|', 'Nunes|Sandra O V|SO|', 'Barbosa|Décio Sabbatini|DS|', 'Sethi|Sumit|S|', 'Zeni|Maiara|M|', 'Mansur|Rodrigo B|RB|', 'Maes|Michael|M|', 'Brietzke|Elisa|E|']
D000375:Aging D000818:Animals D015415:Biomarkers D003865:Depressive Disorder, Major D006801:Humans D018384:Oxidative Stress
Accelerated aging Major depressive disorder Clinical implications Oxidative stress