Enhancement of Radiotherapy with Human Mesenchymal Stem Cells Containing Gold Nanoparticles.
Radiotherapy is a common approach for the treatment of a wide variety of cancer types. Available data indicate that nanoparticles can enhance the effect of radiotherapy. We report the use of human mesenchymal stem cells to selectively deliver gold nanoparticles (GNPs) to MDA-MB-231 breast tumor xenografts in mice for the purpose of enhancing the effect of radiation therapy. Targeted delivery of GNPs to the tumor site, followed by irradiation of the tumor, enabled control of tumor growth. The results indicate that tumor-selective GNP delivery by human mesenchymal stem cells may represent a viable way to enhance the effectiveness of radiotherapy.
['Pullambhatla|Mrudula|M|', 'Rowe|Steven P|SP|', 'Lisok|Ala|A|', 'Wang|Yuchuan|Y|', 'Todd|Gabriele Putz|GP|', 'Danilkovitch|Alla|A|', 'Pomper|Martin G|MG|']
D000818:Animals D001943:Breast Neoplasms D005260:Female D006046:Gold D006801:Humans D059630:Mesenchymal Stem Cells D053768:Metal Nanoparticles D051379:Mice
targeted delivery MSCs breast cancer molecular imaging nanomedicine tumor microenvironment