Highly Selective Olefin-Assisted PdII -Catalyzed Oxidative Alkynylation of Enallenes.
An olefin-assisted, palladium-catalyzed oxidative alkynylation of enallenes for regio- and stereoselective synthesis of substituted trienynes has been developed. The reaction shows a broad substrate scope and good tolerance for various functional groups on the allene moiety, including carboxylic acid esters, free hydroxyls, imides, and alkyl groups. Also, a wide range of terminal alkynes with electron-donating and electron-withdrawing aryls, heteroaryls, alkyls, trimethylsilyl, and free hydroxyl groups are tolerated.
['Henry|Jeffrey L|JL|', 'Posevins|Daniels|D|', 'Yang|Bin|B|', 'Qiu|Youai|Y|', 'Bäckvall|Jan-E|JE|http://orcid.org/0000-0001-8462-4176']
olefin-assisted oxidation alkynylation enallene palladium