Effectiveness and safety of unilateral pedicle screw fixation in transforaminal lumbar interbody fusion (TLIF): a systematic review and meta-analysis.
PURPOSE
To evaluate the effectiveness and safety of unilateral pedicle screw fixation in transforaminal lumbar interbody fusion (TLIF) by comparing with bilateral pedicle screw fixation.


MATERIALS AND METHODS
PubMed, EMBASE, and the Cochrane Central Register of Controlled Trial database were used to search and identify clinical prospective trials that evaluated the efficacy and safety of unilateral fixation as compared with bilateral fixation in TLIF surgery. The methodological qualities of studies were assessed using the PEDro (Physiotherapy Evidence Database) score and Newcastle-Ottawa Scale.


RESULTS
Fourteen prospective studies comprising 954 participants were analyzed. Data synthesis show lower fusion rate (P = 0.03) and more cage migration (P = 0.04) in unilateral group compared to bilateral group. There was no significant difference in visual analog scale (VAS), Oswestry Disability Index (ODI), the Short Form 36 Health Survey (SF-36) physical component score (PCS), and length of hospital stay between unilateral and bilateral groups. The unilateral group had shorter operative time (P < 0.00001) and less blood loss (P = 0.0007).


CONCLUSIONS
Based on this systematic review and meta-analysis, the unilateral fixation in TLIF may achieve a similar clinical outcome and reduce blood loss and operative time when compared with that in bilateral fixation. However, the unilateral fixation may produce lower fusion rate and more cage migration than bilateral fixation in TLIF.
['Ren|Chunpeng|C|', 'Qin|Rujie|R|', 'Sun|Penghao|P|', 'Wang|Peng|P|']
D016063:Blood Loss, Surgical D006801:Humans D055959:Intervertebral Disc Degeneration D007902:Length of Stay D008159:Lumbar Vertebrae D061646:Operative Time D010147:Pain Measurement D065289:Pedicle Screws D011446:Prospective Studies D013123:Spinal Fusion D016896:Treatment Outcome D064232:Visual Analog Scale
Unilateral Pedicle screw Transforaminal lumbar interbody fusion Meta-analysis Bilateral