4-Hydroxycinnamic acid suppresses airway inflammation and mucus hypersecretion in allergic asthma induced by ovalbumin challenge.
In this study, we investigated whether 4-hydroxycinnamic acid (HA) has a palliative effect on asthmatic inflammatory responses using a mouse model of ovalbumin (OVA)-induced allergic asthma. The mice were divided into five groups, each consisting of seven females (normal control phosphate-buffered saline); OVA (OVA sensitization/challenge); dexamethasone (DEX, OVA sensitization/challenge + dexamethasone 3 mg/kg); HA-10 and HA-20 OVA sensitization/challenge + HA 10 and 20 mg/kg, respectively). Mice treated with HA showed a reduction in airway hyperresponsiveness and in the number of inflammatory cells in bronchoalveolar lavage fluid (BALF) compared with asthmatic control. HA treatment also reduced the levels of interleukin (IL)-5 and IL-13 in BALF and of OVA-specific immunoglobulin E in the serum compared with asthmatic control. HA treatment relieved airway inflammation and mucus overproduction caused by OVA exposure. Additionally, HA inhibited the increases in levels of nuclear factor kappa B, inducible nitric oxide synthase, and cyclooxygenase-2 that normally occur after OVA exposure. HA treatment also reduced the activity and protein level of matrix metalloproteinase-9. Taken together, HA effectively suppressed asthmatic airway inflammation and mucus production caused by OVA exposure. These findings indicate that HA has the potential to be used as a therapeutic agent for asthma.
['Ko|Je-Won|JW|https://orcid.org/0000-0001-6272-3544', 'Kwon|Hyung-Jun|HJ|', 'Seo|Chang-Seob|CS|', 'Choi|Seong-Jin|SJ|https://orcid.org/0000-0002-3918-7381', 'Shin|Na-Rae|NR|https://orcid.org/0000-0002-9180-1860', 'Kim|Sung-Hwan|SH|', 'Kim|Yong-Hyun|YH|', 'Kim|Jong-Choon|JC|', 'Kim|Min-Seok|MS|', 'Shin|In-Sik|IS|']
D000818:Animals D000893:Anti-Inflammatory Agents D001249:Asthma D001992:Bronchoalveolar Lavage Fluid D003373:Coumaric Acids D051546:Cyclooxygenase 2 D016207:Cytokines D005260:Female D007073:Immunoglobulin E D007249:Inflammation D008168:Lung D020780:Matrix Metalloproteinase 9 D051379:Mice D008807:Mice, Inbred BALB C D009093:Mucus D052247:Nitric Oxide Synthase Type II D010047:Ovalbumin D011422:Propionates D013047:Specific Pathogen-Free Organisms
inflammation asthma nuclear factor kappa B metalloproteinase-9 4-hydroxycynnamic acid