Pilot study shows right ventricular diastolic function impairment in young children with obstructive respiratory disease.
AIM
This study determined cardiovascular impairment in young children with obstructive respiratory disease who were assessed using the opening interrupter technique (RINT).


METHODS
This pilot study enrolled 41 children who had been referred to pulmonology and allergology specialists at the University of Catania, Italy, from March to July 2017: 23 (mean age 4.13 ± 0.62 years) had chronic coughs and wheezing and 18 controls (mean age 4.27 ± 0.66 years) had obstructive chest disease, but were otherwise healthy. Airway resistance was evaluated using RINT and cardiac function by studying the ejection fraction, pulmonary artery systolic pressure (PASP), tricuspid annular plane systolic excursion and tricuspid flow propagation velocity (TFPV).


RESULTS
The RINT and PASP values were significantly higher in the patient group when compared to the controls, but the TFPV values were lower. A direct and significant Spearman's correlation coefficient (r) between RINT and PASP values was observed (r = 0.81). We found a significant inverse correlation between RINT and TFPV (r = -0.83), as well as TFPV and PASP (r = -0.78).


CONCLUSION
This study showed that children with obstructive respiratory diseases had a major risk of cardiovascular impairment. Impaired diastolic function of the right ventricle occurred very early when airway resistance was abnormally increased.
['Manti|S|S|', 'Parisi|G F|GF|0000-0003-4291-0195', 'Giacchi|V|V|', 'Sciacca|P|P|0000-0003-2642-316X', 'Tardino|L|L|', 'Cuppari|C|C|', 'Salpietro|C|C|', 'Chikermane|A|A|', 'Leonardi|S|S|']
D000403:Airway Resistance D002675:Child, Preschool D015331:Cohort Studies D003971:Diastole D005260:Female D006801:Humans D008297:Male D010865:Pilot Projects D012120:Respiration Disorders D018497:Ventricular Dysfunction, Right
Obstructive respiratory disease Cardiovascular impairment Opening interrupter technique Pulmonary function Right cardiac function