Pd-Catalyzed Regioselective Activation of gem-Difluorinated Cyclopropanes: A Highly Efficient Approach to 2-Fluorinated Allylic Scaffolds.
An unprecedented Pd-catalyzed regioselective activation of gem-difluorinated cyclopropanes induced by C-C bond cleavage is reported. It provides a general and efficient access to a variety of 2-fluoroallylic amines, ethers, esters, and alkylation products in high Z-selectivity, which are important skeletons in many biologically active molecules. In addition, the transformation represents the first general application of gem-difluorinated cyclopropanes as reaction partners in transition-metal-catalyzed cross-coupling reaction.
['Xu|Jun|J|', 'Ahmed|Ebrahim-Alkhalil|EA|', 'Xiao|Bin|B|', 'Lu|Qian-Qian|QQ|', 'Wang|Yun-Long|YL|', 'Yu|Chu-Guo|CG|', 'Fu|Yao|Y|']
D000478:Alkylation D002384:Catalysis D003521:Cyclopropanes D054879:Halogenation D015394:Molecular Structure D010165:Palladium D013237:Stereoisomerism
gem-difluorinated cyclopropanes C(sp3)F activation CC bond cleavage fluorinated compounds palladium