New emergence pattern with variant porcine epidemic diarrhea viruses, South Korea, 2012-2015.
Since outbreaks of porcine epidemic diarrhea virus (PEDV) in the United States in 2013, explosive outbreaks of PED in South Korea have infected all age groups of pigs in 2014-2015year. This study analyzed a large collection of the Spike protein coding gene to infer the spatial-temporal diffusion history of PEDV. The studying results suggested that PEDVs in Korea belonged to different genogroups. While classical G1 was continuingly circulating between provinces of Korea, the pandemic G2a were recently introduced from China and USA. By the application of Bayesian phylogeographical analysis, this study demonstrated the spatial-temporal transmission of PEDVs within Korea. Of the recent emerged G2a viruses, J3142 strains showed potential recombination breakpoint (376-2,143nt) of S1 gene between KNU1303_Korea strain_G2a (KJ451046) and 45RWVCF0712_Thailand strain_G2b (KF724935). The pandemic G2a virus was partial neutralized by the antibodies invoked by the G1- based PED vaccine virus.
['Chung|Hee-Chun|HC|', 'Lee|Jee-Hoon|JH|', 'Nguyen|Van Giap|VG|', 'Huynh|Thi My Le|TML|', 'Lee|Ga-Eun|GE|', 'Moon|Hyoung-Joon|HJ|', 'Park|Seong-Jun|SJ|', 'Kim|Hye-Kwon|HK|', 'Park|Bong Kyun|BK|']
D000818:Animals D021821:Communicable Diseases, Emerging D018352:Coronavirus Infections D003967:Diarrhea D049674:History, 21st Century D010802:Phylogeny D053485:Porcine epidemic diarrhea virus D016865:Reassortant Viruses D011995:Recombination, Genetic D056910:Republic of Korea D013552:Swine D013553:Swine Diseases D014764:Viral Proteins
South Korea Porcine epidemic diarrhea virus Isolation Novel strains Piglets