The Journey of Lipoproteins Through the Cell: One Birthplace, Multiple Destinations.
Bacterial lipoproteins are a very diverse group of proteins characterized by the presence of an N-terminal lipid moiety that serves as a membrane anchor. Lipoproteins have a wide variety of crucial functions, ranging from envelope biogenesis to stress response. In Gram-negative bacteria, lipoproteins can be targeted to various destinations in the cell, including the periplasmic side of the cytoplasmic or outer membrane, the cell surface or the external milieu. The sorting mechanisms have been studied in detail in Escherichia coli, but exceptions to the rules established in this model bacterium exist in other bacteria. In this chapter, we will present the current knowledge on lipoprotein sorting in the cell. Our particular focus will be on the surface-exposed lipoproteins that appear to be much more common than previously assumed. We will discuss the different targeting strategies, provide numerous examples of surface-exposed lipoproteins and discuss the techniques used to assess their surface exposure.
['Szewczyk|J|J|', 'Collet|J-F|JF|']
D000215:Acylation D001425:Bacterial Outer Membrane Proteins D006090:Gram-Negative Bacteria D008074:Lipoproteins D011499:Protein Processing, Post-Translational D021381:Protein Transport
Gram-negative bacteria Lipoprotein sorting Surface-exposed lipoproteins BamA Lipoprotein biogenesis Lol system LolA RcsF