Computed tomography guided percutaneous injection of a mixture of lipiodol and methylene blue in rabbit lungs: evaluation of localization ability for video-assisted thoracoscopic surgery.
Preoperative localization is necessary prior to video assisted thoracoscopic surgery for the detection of small or deeply located lung nodules. We compared the localization ability of a mixture of lipiodol and methylene blue (MLM) (0.6 mL, 1:5) to methylene blue (0.5 mL) in rabbit lungs. CT-guided percutaneous injections were performed in 21 subjects with MLM and methylene blue. We measured the extent of staining on freshly excised lung and evaluated the subjective localization ability with 4 point scales at 6 and 24 hr after injections. For MLM, radio-opacity was evaluated on the fluoroscopy. We considered score 2 (acceptable) or 3 (excellent) as appropriate for localization. The staining extent of MLM was significantly smaller than methylene blue (0.6 vs 1.0 cm, P<0.001). MLM showed superior staining ability over methylene blue (2.8 vs 2.2, P=0.010). Excellent staining was achieved in 17 subjects (81%) with MLM and 8 (38%) with methylene blue (P=0.011). An acceptable or excellent radio-opacity of MLM was found in 13 subjects (62%). An appropriate localization rate of MLM was 100% with the use of the directly visible ability and radio-opacity of MLM. MLM provides a superior pulmonary localization ability over methylene blue.
['Jin|Kwang Nam|KN|', 'Lee|Kyung Won|KW|', 'Kim|Tae Jung|TJ|', 'Song|Yong Sub|YS|', 'Kim|Dong Il|DI|']
D000818:Animals D004998:Ethiodized Oil D005471:Fluoroscopy D007279:Injections, Subcutaneous D008168:Lung D008751:Methylene Blue D011300:Preoperative Care D011817:Rabbits D003074:Solitary Pulmonary Nodule D013194:Staining and Labeling D020775:Thoracic Surgery, Video-Assisted D013906:Thoracoscopy D014057:Tomography, X-Ray Computed
Methylene Blue Lung Ethiodized Oil Radiology, Interventional Tomography, X-Ray Computed