Effect of anemia correction on left ventricular structure and filling pressure in anemic patients without overt heart disease.
BACKGROUND/AIMS
There are few data on the effects of low hemoglobin levels on the left ventricle (LV) in patients without heart disease. The objective of this study was to document changes in the echocardiographic variables of LV structure and function after the correction of anemia without significant cardiovascular disease.


METHODS
In total, 34 iron-deficiency anemia patients (35 ± 11 years old, 32 females) without traditional cardiovascular risk factors or cardiovascular disease and 34 age- and gender-matched controls were studied. Assessments included history, physical examination, and echocardiography. Of the 34 patients with anemia enrolled, 20 were followed and underwent echocardiography after correction of the anemia.


RESULTS
There were significant differences between the anemia and control groups in LV diameter, left ventricular mass index (LVMI), left atrial volume index (LAVI), peak mitral early diastolic (E) velocity, peak mitral late diastolic (A) velocity, E/A ratio, the ratio of mitral to mitral annular early diastolic velocity (E/E'), stroke volume, and cardiac index. Twenty patients underwent follow-up echocardiography after treatment of anemia. The follow-up results showed significant decreases in the LV end-diastolic and end-systolic diameters and LVMI, compared with baseline levels. LAVI, E velocity, and E/E' also decreased, suggesting a decrease in LV filling pressure.


CONCLUSIONS
Low hemoglobin level was associated with larger cardiac chambers, increased LV, mass and higher LV filling pressure even in the subjects without cardiovascular risk factors or overt cardiovascular disease. Appropriate correction of anemia decreased LV mass, LA volume, and E/E'.
['Cho|In-Jeong|IJ|', 'Mun|Yeung Chul|YC|', 'Kwon|Ki Hwan|KH|', 'Shin|Gil Ja|GJ|']
D000328:Adult D018798:Anemia, Iron-Deficiency D015415:Biomarkers D016022:Case-Control Studies D015150:Echocardiography, Doppler D005260:Female D006352:Heart Ventricles D006397:Hematinics D006454:Hemoglobins D006801:Humans D008297:Male D008875:Middle Aged D011446:Prospective Studies D020127:Recovery of Function D013997:Time Factors D016896:Treatment Outcome D016277:Ventricular Function, Left D017725:Ventricular Pressure D020257:Ventricular Remodeling D055815:Young Adult
Anemia Ventricular remodeling