Effect of cyclosporine A versus tacrolimus on the response to antiviral therapy after hepatitis C genotype-4 recurrence post-liver transplantation: A prospective cohort trial.
WHAT IS KNOWN AND OBJECTIVE
The influence of immunosuppression on the response to antiviral therapy (AVT) for recurrent hepatitis C virus (HCV) infection in liver transplant (LT) recipients remains controversial, especially for the rarely investigated genotype 4. This study aims to compare the effects of the two widely used calcineurin inhibitors (CNIs) (cyclosporine A (CsA) and tacrolimus (Tac)) on the therapeutic response to different AVT regimens.


METHODS
A prospective, dual-centre, cohort study of 126 Egyptian living donor liver transplant (LDLT) recipients with recurrent HCV genotype 4 infection, who were categorized into three groups according to the AVT used. Group I received pegylated interferon (Peg-IFN-α 2a) plus ribavirin (RBV) (n = 44), group II received the direct antiviral agent (DAA) sofosbuvir plus RBV (n = 52) and group III received daclatasvir and sofosbuvir (also DAAs) plus RBV (n = 30). Each group was further subdivided according to the primary immunosuppression (CsA or Tac). The sustained virological response (SVR) and relapse rates were considered the primary therapeutic outcomes of AVT.


RESULTS
No significant intergroup differences were observed in the achievement of primary and secondary outcomes. SVR rates in the IFN-based regimen were 75% and 66.7% in CsA and Tac users and 81.2% and 83% in DAAs, respectively. Relapse rates in the IFN-based regimen were 10% and 16.7% in CsA and Tac users and 12.5% and 14.9% in DAAs, respectively.


WHAT IS NEW AND CONCLUSION
Within the limitations of a relatively small study, CsA did not offer an advantage over Tac regarding the response to AVT after HCV genotype 4 recurrence in LDLT recipients.
['El-Hamamsy|Manal|M|', 'Montasser|Iman Fawzy|IF|', 'Mansy|Azza El-Sayed|AE|', 'Nabet|Dina Ezzeldin|DE|https://orcid.org/0000-0003-0782-4574', 'El-Meteini|Mahmoud|M|']
D000328:Adult D000368:Aged D000998:Antiviral Agents D065095:Calcineurin Inhibitors D016572:Cyclosporine D004347:Drug Interactions D004359:Drug Therapy, Combination D005260:Female D005838:Genotype D016174:Hepacivirus D019698:Hepatitis C, Chronic D006801:Humans D007166:Immunosuppressive Agents D016898:Interferon-alpha D016031:Liver Transplantation D008297:Male D008875:Middle Aged D011092:Polyethylene Glycols D011446:Prospective Studies D011994:Recombinant Proteins D012008:Recurrence D012254:Ribavirin D000069474:Sofosbuvir D016559:Tacrolimus D055815:Young Adult
antiviral therapy hepatitis C genotype-4 liver transplantation calcineurin inhibitors sustained virological response