The role of the intestinal microbiota in uremic solute accumulation: a focus on sulfur compounds.
The gut microbiota is considered to be a novel important factor to take into account in the pathogenesis of chronic kidney disease and uremia. Much attention has been paid to specific uremic retention solutes of microbial origin, such as indoxyl sulfate, p-cresyl sulfate, and trimethylamine-N-oxide. However, other novel less well studied compounds, such as hydrogen sulfide and related sulfur metabolites (sulfane sulfur, lanthionine, etc.), should be included in a more comprehensive appraisal of this topic, in light of the potential therapeutic opportunities for the future.
['Perna|Alessandra F|AF|http://orcid.org/0000-0003-4048-9392', 'Glorieux|Griet|G|', 'Zacchia|Miriam|M|', 'Trepiccione|Francesco|F|', 'Capolongo|Giovanna|G|', 'Vigorito|Carmela|C|', 'Anishchenko|Evgeniya|E|', 'Ingrosso|Diego|D|']
D005492:Folic Acid D000069196:Gastrointestinal Microbiome D006801:Humans D013457:Sulfur Compounds D014511:Uremia
Microbiota Chronic kidney disease Uremia Hydrogen sulfide Sulfane sulfur Lanthionine Dialysis Homocysteine Uremic toxins