Telomeres in lung disease.
Telomeres are DNA-protein structures that cap the ends of chromosomes; telomerase is the enzyme that ensures their integrity. Telomere biology has recently been implicated in the pathogenesis of a variety of lung diseases, including idiopathic pulmonary fibrosis, chronic obstructive pulmonary disease/emphysema, and lung cancer. This review highlights recent discoveries pertaining to the role of telomere biology in lung disease.
['Gansner|John M|JM|', 'Rosas|Ivan O|IO|']
D006801:Humans D054990:Idiopathic Pulmonary Fibrosis D008171:Lung Diseases D008175:Lung Neoplasms D009154:Mutation D029424:Pulmonary Disease, Chronic Obstructive D019098:Telomerase D016615:Telomere D057170:Translational Research, Biomedical
idiopathic pulmonary fibrosis chronic obstructive pulmonary disease COPD IPF TERC TERT telomerase RNA component telomerase reverse transcriptase