Encapsulated follicular variant of papillary thyroid carcinoma/noninvasive follicular thyroid neoplasm with papillary-like nuclear features with Spindle Cell Metaplasia: Case report and review of literature.
Spindle cell lesions of the thyroid are rare overall, and span a wide clinical spectrum that ranges from spindle cell metaplasia (SCM1) to anaplastic carcinoma. Their differentiation is only seldom straightforward, and usually requires the integration of the clinical, histological and immunohistochemical data. Only a handful of publications have described cases of SCM in the thyroid and we add to that literature by reporting a unique case of encapsulated follicular variant of papillary thyroid carcinoma/noninvasive follicular thyroid neoplasm with papillary-like nuclear features with SCM. In addition, we review the literature on the relationship between SCM and different thyroid lesions, summarizing the morphological and immunohistochemical features that aid in its differentiation from more aggressive spindle cell proliferations.
['Haroon Al Rasheed|Mohamed Rizwan|MR|', 'Acosta|Andres|A|', 'Tarjan|Gabor|G|']
D018263:Adenocarcinoma, Follicular D000368:Aged D014408:Biomarkers, Tumor D002277:Carcinoma D002291:Carcinoma, Papillary D005260:Female D006801:Humans D007150:Immunohistochemistry D000077273:Thyroid Cancer, Papillary D013964:Thyroid Neoplasms
EFVPTC Endocrine Follicular neoplasm HBME-1 NIFTP Spindled lesion