Histone H2AX and the small RNA pathway modulate both non-homologous end-joining and homologous recombination in plants.
Using a zinc finger nuclease (ZFN) that creates a site-specific DNA double-strand break (DSB) at the endogenous ADH1 locus, we provide genetic evidence that histone H2AX and DSB-induced small RNAs modulate DNA repair by both non-homologous end-joining (NHEJ) and homologous recombination (HR) in the model plant Arabidopsis thaliana.
['Qi|Yiping|Y|', 'Zhang|Yong|Y|', 'Baller|Joshua A|JA|', 'Voytas|Daniel F|DF|']
D017360:Arabidopsis D029681:Arabidopsis Proteins D053903:DNA Breaks, Double-Stranded D059766:DNA End-Joining Repair D004260:DNA Repair D006657:Histones D059765:Homologous Recombination D009154:Mutation D011523:Protoplasts D018749:RNA, Plant
H2AX Small RNA Zinc finger nuclease (ZFN) Arabidopsis thaliana DNA double-strand break (DSB) repair