Fatal Case of Chronic Jamestown Canyon Virus Encephalitis Diagnosed by Metagenomic Sequencing in Patient Receiving Rituximab.
A 56-year-old man receiving rituximab who had months of neurologic symptoms was found to have Jamestown Canyon virus in cerebrospinal fluid by clinical metagenomic sequencing. The patient died, and postmortem examination revealed extensive neuropathologic abnormalities. Deep sequencing enabled detailed characterization of viral genomes from the cerebrospinal fluid, cerebellum, and cerebral cortex.
['Solomon|Isaac H|IH|', 'Ganesh|Vijay S|VS|', 'Yu|Guixia|G|', 'Deng|Xian Ding|XD|', 'Wilson|Michael R|MR|', 'Miller|Steve|S|', 'Milligan|Tracey A|TA|', 'Mukerji|Shibani S|SS|', 'Mathewson|Abigail|A|', 'Linxweiler|Justin|J|', 'Morse|Darlene|D|', 'Ritter|Jana M|JM|', 'Staples|J Erin|JE|', 'Hughes|Holly|H|', 'Gould|Carolyn V|CV|', 'Sabeti|Pardis C|PC|', 'Chiu|Charles Y|CY|', 'Piantadosi|Anne|A|']
D000914:Antibodies, Viral D002141:Encephalitis Virus, California D004670:Encephalitis, California D006801:Humans D008297:Male D054892:Metagenome D056186:Metagenomics D008875:Middle Aged D000069283:Rituximab
Jamestown Canyon virus encephalitis rituximab arbovirus metagenomic next-generation sequencing monoclonal antibody orthobunyavirus vector-borne infections viruses