Direct α-arylation of ethers through the combination of photoredox-mediated C-H functionalization and the Minisci reaction.
The direct α-arylation of cyclic and acyclic ethers with heteroarenes has been accomplished through the design of a photoredox-mediated CH functionalization pathway. Transiently generated α-oxyalkyl radicals, produced from a variety of widely available ethers through hydrogen atom transfer (HAT), were coupled with a range of electron-deficient heteroarenes in a Minisci-type mechanism. This mild, visible-light-driven protocol allows direct access to medicinal pharmacophores of broad utility using feedstock substrates and a commercial photocatalyst.
['Jin|Jian|J|', 'MacMillan|David W C|DW|']
D000478:Alkylation D002244:Carbon D002384:Catalysis D004579:Electron Transport D004987:Ethers D006859:Hydrogen D008027:Light D010084:Oxidation-Reduction
ethers CH functionalization alkylation heterocycles photoredox catalysis