MIF -173G/C (rs755622) polymorphism modulates coronary artery disease risk: evidence from a systematic meta-analysis.
BACKGROUND
Coronary artery disease (CAD) remains one of the major causes of death in humans. Genetic testing may allow early detection and prevention of this disease. This study aimed to investigate the association between the macrophage migration inhibitory factor (MIF) -173G/C (rs755622) polymorphism and susceptibility to CAD based on a meta-analysis.


METHODS
We searched several databases to identify observational case-control studies investigating the association between the MIF -173G > C (rs755622) polymorphism and CAD risk published before July 30, 2019. Data were analyzed using the STATA software.


RESULTS
Six studies, comprising a total of 1172 CAD cases and 1564 controls evaluated for MIF polymorphisms, were included. The occurrence of CAD was found to be associated with the C allele of the MIF rs755622 SNP in the total population (C/G, OR = 1.489, 95% CI = 1.223-1.813). Further, MIF -173G/C polymorphism was significantly associated with CAD under the allelic model in the Asian (C/G, OR = 1.775, 95% CI = 1.365-2.309) and Caucasian (C/G, OR = 1.288, 95% CI 1.003-1.654) subgroups. The data showed that the risk of CAD was higher in the population carrying the C allele.


CONCLUSIONS
We found evidence of associations between MIF -173C/G and CAD susceptibility in the Asian and Caucasian populations.
['Li|De-Yang|DY|', 'Zhang|Jin-Yu|JY|', 'Chen|Qing-Jie|QJ|', 'Liu|Fen|F|', 'Zhao|Qian|Q|', 'Gao|Xiao-Ming|XM|', 'Li|Xiao-Mei|XM|', 'Yang|Yi-Ning|YN|0000-0002-8332-8508']
D044466:Asians D016022:Case-Control Studies D003324:Coronary Artery Disease D056726:Genetic Association Studies D020022:Genetic Predisposition to Disease D000082742:Heart Disease Risk Factors D006801:Humans D019746:Intramolecular Oxidoreductases D008263:Macrophage Migration-Inhibitory Factors D064887:Observational Studies as Topic D020641:Polymorphism, Single Nucleotide D018570:Risk Assessment D044465:Whites
Polymorphism Coronary artery disease Meta-analysis Macrophage migration inhibitory factor