Accuracy of nigrosome-1 detection to discriminate patients with Parkinson's disease and essential tremor.
PURPOSE
The use of susceptibility weighted imaging in high field magnetic resonance imaging scanners can detect the nigrosome-1 area located in the caudo-lateral region of the pars compacta in the substantia nigra. This structure comprises a significant amount of dopaminergic neurons and degenerates in the early stages of Parkinson's disease. Essential tremor is a neurological condition that in some cases could be confused with the early stages of Parkinson's disease with a possible error in clinical diagnosis. Our purpose is to evaluate the accuracy of nigrosome-1 detection by high resolution magnetic resonance imaging to discriminate Parkinson's disease from essential tremor.


METHODS
A case-control study compared patients with a clinical diagnosis of Parkinson's disease and essential tremor. Magnetic resonance imaging studies were performed using a 3T magnetic resonance imaging scanner. The susceptibility weighted imaging sequence was obtained in the axial plane with an isotropic voxel of 0.75 mm. Two independent neuroradiologists evaluated the images without access to clinical patient data.


RESULTS
Sixteen patients were included in each group (Parkinson's disease and essential tremor). Average age: Parkinson's disease group: 71.3 (SD 6.3) and essential tremor group: 68.3 (SD 12.3). For the first evaluator, the nigrosome-1 area was absent in 15 patients with Parkinson's disease and in two with essential tremor and for the second evaluator was absent in 15 patients with Parkinson's disease and four with essential tremor. The sensitivity/specificity for the diagnosis of Parkinson's disease was 93.75%/87.5% for the first evaluator and 93.75%/75% for the second evaluator.


CONCLUSION
The detection of the nigrosome-1 area is a useful tool in the differential diagnosis between Parkinson's disease and essential tremor, with high sensitivity and specificity.
['Perez Akly|Manuel S|MS|https://orcid.org/0000-0002-5144-6462', 'Stefani|Carla V|CV|', 'Ciancaglini|Lucía|L|', 'Bestoso|José S|JS|', 'Funes|Jorge A|JA|', 'Bauso|Diego J|DJ|', 'Besada|Cristina H|CH|']
D000368:Aged D000369:Aged, 80 and over D016022:Case-Control Studies D003937:Diagnosis, Differential D020329:Essential Tremor D005260:Female D006801:Humans D008279:Magnetic Resonance Imaging D008297:Male D008875:Middle Aged D010300:Parkinson Disease D065842:Pars Compacta D012680:Sensitivity and Specificity D013378:Substantia Nigra
nigrosome-1 essential tremor Parkinson’s disease