Early Experience With Methylprednisolone on SARS-CoV-2 Infection in the African American Population, a Retrospective Analysis.
Background
Coronavirus disease-19 (COVID-19) is associated with acute kidney injury (AKI) and acute respiratory distress syndrome (ARDS) with high mortality rates. In African American (AA) populations, COVID-19 presentations and outcomes are more severe. NIH and Interim WHO guidelines had suggested against the use of corticosteroids unless in clinical trials until the recent publication of the RECOVERY trial. Here, we analyzed the treatment effect of methylprednisolone on patients with AKI and ARDS during the initial 2 months of COVID-19 and detail the learning effect within our institution.


Methods
Between March 1 and April 30, 2020, 75 AA patients met our inclusion criteria for ARDS and AKI, of which 37 had received corticosteroids. Twenty-eight-day mortality, improvement in PaO2/FiO2 ratio, and renal function were analyzed. The impact of methylprednisolone treatment was assessed with multivariable methods.


Results
Survival in the methylprednisolone group reached 51% at 21 days compared to 29% in the non-corticosteroid group (P < .001). Methylprednisolone improved the likelihood of renal function improvement. PaO2/FiO2 ratio in the methylprednisolone group improved by 73% compared to 45% in the non-corticosteroid group (P = .01). Age, gender, BMI, preexisting conditions, and other treatment factors did not show any impact on renal or PaO2/FiO2 ratio improvement. The use of anticoagulants, the month of treatment, and AKI during hospitalization also influenced outcomes.


Conclusion
In AA COVID-19 positive patients with ARDS and AKI, IV methylprednisolone lowered the incidence of mortality and improved the likelihood of renal and lung function recovery. Further investigation with a randomized control trial of corticosteroids is warranted.
['Saggi|Subodh J|SJ|', 'Nath|Sridesh|S|', 'Culas|Roshni|R|', 'Chittalae|Seema|S|', 'Burza|Aaliya|A|', 'Srinivasan|Maya|M|', 'Abdul|Rishard|R|', 'Silver|Benjamin|B|', 'Lora|Alnardo|A|https://orcid.org/0000-0002-1995-1557', 'Ibtida|Ishmam|I|', 'Chokshi|Tanuj|T|', 'Capric|Violeta|V|', 'Mohamed|Ammar|A|', 'Worah|Samrat|S|', 'OuYang|Jie|J|', 'Geraghty|Patrick|P|https://orcid.org/0000-0003-1647-5505', 'Gruessner|Angelika|A|', 'Salifu|Moro O|MO|']
methylprednisolone COVID-19 acute kidney injury acute respiratory distress syndrome