Peripheral nerve proteins as potential autoantigens in acute and chronic inflammatory demyelinating polyneuropathies.
Guillain-Barré syndrome is classified into acute inflammatory demyelinating polyneuropathy and acute motor axonal neuropathy. Whereas autoantibodies to GM1 or GD1a induce the development of acute motor axonal neuropathy, pathogenic autoantibodies have yet to be identified in acute inflammatory demyelinating polyneuropathy and chronic inflammatory demyelinating polyneuropathy. This review highlights the importance of autoantibodies to peripheral nerve proteins in the physiopathology of acute and chronic inflammatory demyelinating polyneuropathies. Moreover, we listed up other potential antigens, which may become helpful biomarkers for acquired, dysimmune demyelinating neuropathies based on their critical functions during myelination and their implications in hereditary demyelinating neuropathies.
['Lim|Jia Pei|JP|', 'Devaux|Jérôme|J|', 'Yuki|Nobuhiro|N|']
D001323:Autoantibodies D001324:Autoantigens D020275:Guillain-Barre Syndrome D006801:Humans D009419:Nerve Tissue Proteins D011115:Polyneuropathies D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Chronic inflammatory demyelinating polyneuropathy Acute inflammatory demyelinating polyneuropathy Autoantibody Charcot–Marie–Tooth disease Experimental autoimmune neuritis Guillain–Barré syndrome