Research progress on the effect of autophagy-lysosomal pathway on tumor drug resistance.
Autophagy is an intracellular degradation pathway that is highly conserved during the evolution of eukaryotes and is based on lysosome. Under nutritional deficiencies or stress, cells can clear damaged and necrotic organelles and proteins through autophagy to maintain the homeostasis of cells and organisms. Studies have found that abnormal autophagy is closely related to the occurrence and development of neurodegenerative diseases and tumors. In order to further understand the relationship between lysosomes and autophagy, tumorigenesis and drug resistance, the role of autophagy-lysosomal pathway in tumor resistance and related mechanisms and the relationship between drug resistance and hypoxia-induced autophagy are discussed in this paper.
['Li|Jiaxin|J|', 'Liu|Gui|G|', 'Li|Long|L|', 'Yao|Zhigang|Z|', 'Huang|Junhui|J|']
D000818:Animals D001343:Autophagy D019008:Drug Resistance, Neoplasm D006706:Homeostasis D006801:Humans D008247:Lysosomes D009369:Neoplasms
Tumor Drug resistance Autophagy Lysosome Hypoxia