Protein-derived Smart Materials for Medical Applications: Elastin-like Polypeptides.
A group of stimulus-responsive biopolymers developed from the hydrophobic domain of tropoelastin is collectively known as elastin-like polypeptides (ELPs). These peptides generally consist of repeated pentapeptide units of the form (VPGXG)n, where X can be any amino acid with the exception of proline. ELPs present wide-ranging possibilities in biomedicine due to their many beneficial characteristics, including tunable phase transition behavior and biological compatibility, along with the absence of immunogenic and pyrogenic characteristics. The present paper reviews the physicochemical characteristics of ELPs and outlines a range of applications in biotechnology and medicine.
['Lin|Rui|R|', 'Wang|Shanshan|S|', 'Liu|Wentian|W|']
D035843:Biomedical Research D001709:Biotechnology D004549:Elastin D006801:Humans D010455:Peptides
Elastin-like polypeptides drug delivery endoscopic
submucosal injection solution inverse temperature phase transition protein purification tissue engineering.