Quantifying Dry Milling in Pharmaceutical Processing: A Review on Experimental and Modeling Approaches.
Particle size reduction by mechanical means is an important unit operation in the pharmaceutical industry, used to improve flow, solubility, and in amorphization of drugs. It is usually achieved by the fracturing of particles under the action of applied energy. Despite being pervasive in the pharmaceutical field, it is one of the least understood processes owing to the complexity of material and process variables involved during milling. To comprehend the process, efforts should be focused on techniques that measure the particle size as well as the control the process. With the ongoing initiative of US FDA to encourage design in quality, the review is focused on some process analytical tools to characterize particle size distribution as well as process modeling tools to simulate particle size reduction. Additionally, an overview of some fundamental aspects related to milling is provided. To this end, the review is limited, mainly concentrating on some of experimental and modeling approaches used to quantify and understand the physics behind the process of dry milling.
['Naik|Shivangi|S|', 'Chaudhuri|Bodhisattwa|B|']
D055598:Chemical Phenomena D003198:Computer Simulation D004339:Drug Compounding D055595:Mechanical Phenomena D008956:Models, Chemical D010316:Particle Size D011208:Powders D011786:Quality Control D012995:Solubility
milling particle size fracture process modeling PAT mathematical model mechanical properties powder technology