Studies towards the synthesis of medermycin via Dötz benzannulation.
The C-arylglycosides are available in enantiomerically pure form via the Dötz benzannulation reaction between Fischer alkenyl chromium carbene complexes and alkynes; it also could be converted to a precursor of medermycin by O-carbamate directed ipso bromination and nitrile substitution in good overall yields.
['Qu|Chunrong|C|', 'Tang|Erqing|E|', 'Loeppky|Richard|R|', 'Deng|Zixin|Z|', 'Pulley|Shon R|SR|', 'Hong|Xuechuan|X|']
D015394:Molecular Structure D009285:Naphthoquinones D013237:Stereoisomerism
Dötz benzannulation C-arylglycoside ipso bromination Fischer carbene complex Streptomyces sp