How has urinary proteomics contributed to the discovery of early biomarkers of acute kidney injury?
In the past decade, analysis of the urinary proteome (urinary proteomics) has intensified in response to the need for novel biomarkers that support early diagnosis of kidney diseases. In particular, this also applies to acute kidney injury, which is a heterogeneous complex syndrome with a still-increasing incidence at the intensive care unit. Unfortunately, this major need remains largely unmet to date. The current report aims to explain why attempts to implement urinary proteomic-discovered acute kidney injury diagnostic candidates in the intensive care unit setting have not yet led to success. Subsequently, some key notes are provided that should enhance the chance of translating selected urinary proteomic candidates to valuable tools for the nephrologist and intensivist in the near future.
['De Loor|Jorien|J|', 'Gevaert|Kris|K|', 'Hoste|Eric|E|', 'Meyer|Evelyne|E|']
D058186:Acute Kidney Injury D000818:Animals D015415:Biomarkers D006348:Cardiac Surgical Procedures D006801:Humans D008297:Male D040901:Proteomics D018805:Sepsis D014556:Urine
urinary proteomics acute kidney injury intensive care unit animal model diagnostic biomarker early detection