Drug Burden Index and Its Association With Hip Fracture Among Older Adults: A National Population-Based Study.
BACKGROUND
The Drug Burden Index (DBI) calculates the total sedative and anticholinergic load of prescribed medications and is associated with functional decline and hip fractures in older adults. However, it is unknown if confounding factors influence the relationship between the DBI and hip fractures. The objective of this study was to evaluate the association between the DBI and hip fractures, after correcting for mortality and multiple potential confounding factors.


METHODS
A competing-risks regression analysis conducted on a prospectively recruited New Zealand community-dwelling older population who had a standardized (International Resident Assessment Instrument) assessment between September 1, 2012, and October 31, 2015, the study's end date. Outcome measures were survival status and hip fracture, with time-varying DBI exposure derived from 90-day time intervals. The multivariable competing-risks regression model was adjusted for a large number of medical comorbidities and activities of daily living.


RESULTS
Among 70,553 adults assessed, 2,249 (3.2%) experienced at least one hip fracture, 20,194 (28.6%) died without experiencing a fracture, and 48,110 (68.2%) survived without a fracture. The mean follow-up time was 14.9 months (range: 1 day, 37.9 months). The overall DBI distribution was highly skewed, with median time-varying DBI exposure ranging from 0.93 (Q1 = 0.0, Q3 = 1.84) to 0.96 (Q1 = 0.0, Q3 = 1.90). DBI was significantly related to fracture incidence in unadjusted (p < .001) and adjusted (p < .001) analyses. The estimated subhazard ratio was 1.52 (95% confidence interval: 1.28-1.81) for those with DBI > 3 compared with those with DBI = 0 in the adjusted analysis.


CONCLUSIONS
In this study, increasing DBI was associated with a higher likelihood of fractures after accounting for the competing risk of mortality and adjusting for confounders. The results of this unique study are important in validating the DBI as a guide for medication management and it could help reduce the risk of hip fractures in older adults.
['Jamieson|Hamish A|HA|', 'Nishtala|Prasad S|PS|', 'Scrase|Richard|R|', 'Deely|Joanne M|JM|', 'Abey-Nesbit|Rebecca|R|', 'Hilmer|Sarah N|SN|', 'Abernethy|Darrell R|DR|', 'Berry|Sarah D|SD|', 'Mor|Vincent|V|', 'Lacey|Cameron J|CJ|', 'Schluter|Philip J|PJ|']
D000058:Accidental Falls D000203:Activities of Daily Living D000368:Aged D018680:Cholinergic Antagonists D005260:Female D006620:Hip Fractures D006801:Humans D006993:Hypnotics and Sedatives D015994:Incidence D057187:Independent Living D008297:Male D054539:Medication Therapy Management D009520:New Zealand D018570:Risk Assessment D012307:Risk Factors
Medications Falls Polypharmacy RAI