Induced adaptation of Bacillus sp. to antimicrobial nanosilver.
The natural ability of Bacillus sp. to adapt to nanosilver cytotoxicity upon prolonged exposure is reported for the first time. The combined adaptive effects of nanosilver resistance and enhanced growth are induced under various intensities of nanosilver-stimulated cellular oxidative stress, ranging from only minimal cellular redox imbalance to the lethal levels of cellular ROS stimulation. An important implication of the present work is that such adaptive effects lead to the ultimate domination of nanosilver-resistant Bacillus sp. in the microbiota, to which nanosilver cytotoxicity is continuously applied.
['Gunawan|Cindy|C|', 'Teoh|Wey Yang|WY|', 'Marquis|Christopher P|CP|', 'Amal|Rose|R|']
D000900:Anti-Bacterial Agents D001407:Bacillus D004352:Drug Resistance, Microbial D053768:Metal Nanoparticles D008826:Microbial Sensitivity Tests D046529:Microscopy, Electron, Transmission D012834:Silver
induced adaptation cellular oxidative stress antimicrobial resistance silver nanoparticles