Glycosides from Buddleja officinalis with their protective effects on photoreceptor cells in light-damaged mouse retinas.
A new phenylethanoid, hebitol IV (1), along with fifteen known glycosides (2-16), were isolated from water extract of the flower buds of Buddleja officinalis. Their structures were elucidated on the basis of 1 D-NMR, 2 D-NMR and MS data. Molecular docking showed the potential activities of the natural products against VEGFR-2. Bioassay results revealed that the compounds 10 and 14 exhibited strong inhibitory activity against VEGFR-2 with IC50 values of 0.51 and 0.32 μM, respectively. Moreover, the potential retinal protective effects of 10 and 14 were then investigated in the mouse model featuring bright light-induced retinal degeneration. The results demonstrated remarkable photoreceptor protective activities of 10 and 14 in vivo.
['Long|Zehai|Z|', 'Du|Xiaoye|X|', 'Wang|Qiyao|Q|', 'Xu|Zhijian|Z|https://orcid.org/0000-0002-3063-8473', 'Li|Bo|B|', 'Zhang|Yong|Y|', 'Chen|Yu|Y|', 'Jia|Qi|Q|', 'Li|Yiming|Y|', 'Zhu|Weiliang|W|']
glycosides Buddleja officinalis photoreceptor protective activity Loganiaceae VEGFR-2 inhibitory activity