Fucoidan and Fucosylated Chondroitin Sulfate Stimulate Hematopoiesis in Cyclophosphamide-Induced Mice.
Application of cytostatics in cancer patients' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed Chordaria flagelliformis (PS-Fuc) and fucosylated chondroitin sulfate from the sea cucumber Massinium magnum (PS-FCS), were studied as stimulators of hematopoiesis after cyclophosphamide immunosuppression in mice. Recombinant granulocyte colony-stimulating factor (r G-CSF) was applied as a reference. Both tested polysaccharides PS-Fuc and PS-FCS have a similar activity to r G-CSF, causing pronounced neutropoiesis stimulation in animals with myelosuppression induced by cyclophosphamide (CPh). Moreover, these compounds are also capable to enhance thrombopoiesis and erythropoiesis. It should be noted that PS-FCS demonstrated a greater activity than r G-CSF. The results indicate the perspective of further studies of PS-Fuc and PS-FCS, since these compounds can be considered as potentially promising stimulators of hematopoiesis. Such drugs are in demand for the accompanying treatment of cancer patients who suffer from hematological toxicity during chemo and/or radiation therapy.
['Anisimova|Natalia|N|', 'Ustyuzhanina|Nadezhda|N|', 'Bilan|Maria|M|', 'Donenko|Fedor|F|', 'Usov|Anatolii|A|', 'Kiselevskiy|Mikhail|M|', 'Nifantiev|Nikolay|N|']
D000818:Animals D002809:Chondroitin Sulfates D003520:Cyclophosphamide D016179:Granulocyte Colony-Stimulating Factor D006410:Hematopoiesis D008297:Male D051379:Mice D011134:Polysaccharides D011994:Recombinant Proteins D012616:Sea Cucumbers
fucoidan fucosylated chondroitin sulfate hematopoiesis cyclophosphamide immunosuppression granulocyte colony-stimulating factor