Lipocalin-2-The myth of its expression and function.
Lipocalin-2 is a functional biomarker for acute and chronic kidney diseases, heart failure and obesity-related medical complications. It is rapidly induced in epithelial cells under stress conditions, but constitutively produced from pre-adipocytes and mature adipocytes. Measuring the lipocalin-2 levels represents an effective approach for risk prediction, patient stratification and disease management. Nevertheless, due to ligand-binding, post-translational modification and protein-protein interaction, lipocalin-2 exists as multiple variants that elicit different pathophysiological functions. To characterize the specific structure-functional relationships of lipocalin-2 variants is critical for the development of biomarker assays with sufficient precision and reliability. Moreover, identifying the pathological forms of lipocalin-2 will provide new therapeutic targets and treatment approaches for obesity-related complications.
['Li|Dahui|D|', 'Yan Sun|Wai|W|', 'Fu|Bowen|B|', 'Xu|Aimin|A|', 'Wang|Yu|Y|']
D058186:Acute Kidney Injury D000818:Animals D015415:Biomarkers D006333:Heart Failure D006801:Humans D000071068:Lipocalin-2 D009765:Obesity D018384:Oxidative Stress D011499:Protein Processing, Post-Translational
lipocalin-2 biomarker heart failure kidney injury metabolic disease