Starch-Mg/Al layered double hydroxide composites as an efficient solid phase extraction sorbent for non-steroidal anti-inflammatory drugs as environmental pollutants.
Using a co-precipitation method, starch-Mg/Al layered double hydroxide (S-Mg/Al LDH) composites were synthesized. Their physicochemical properties were assessed by Fourier-transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and thermo-gravimetric analysis. The quantification of six non-steroidal anti-inflammatory drugs (NSAIDs) was conducted using real samples (e.g., hospital waste water, river water, sewage treatment plant water, and tablet formulations) by gas chromatography-mass spectrometry. For the development of this method, the system was optimized in terms of several key variables (e.g., pH, flow rate, and eluent type/volume). The developed method for NSAIDs exhibited good resolution, sensitivity, reproducibility, and specificity even in complex matrices with limits of detection between 4 and 20 pg/mL. Hence, S-Mg/Al LDH composites were proven to be efficient and fast solid phase extraction (SPE) sorbents for NSAIDs. In addition, each LDH-SPE cartridge showed good reusability without a noticeable change in performance (e.g., up to 30 cycles) and target recoveries between 99.5 - 82.9 %. This work should open up new opportunities for a sesnsitive and sustainable quantitative method for the determination of NSAIDs in complex samples.
['Mohiuddin|Irshad|I|', 'Grover|Aman|A|', 'Aulakh|Jatinder Singh|JS|', 'Malik|Ashok Kumar|AK|', 'Lee|Sang Soo|SS|', 'Brown|Richard J C|RJC|', 'Kim|Ki-Hyun|KH|']
D000894:Anti-Inflammatory Agents, Non-Steroidal D004785:Environmental Pollutants D008401:Gas Chromatography-Mass Spectrometry D006878:Hydroxides D057230:Limit of Detection D004364:Pharmaceutical Preparations D015203:Reproducibility of Results D052616:Solid Phase Extraction D013213:Starch D014874:Water Pollutants, Chemical
Layered double hydroxide NSAIDs Morphology Starch Thermal stability