Development and function of Foxp3(+) regulatory T cells.
Regulatory T cells (Tregs) have been recognized as having a major role in maintaining peripheral tolerance and preventing and limiting autoimmune and chronic inflammatory diseases. Tregs derive from the thymus and also develop peripherally. In this review, we discuss recent progress in our understanding of the basic mechanisms involved in Treg development and function in protecting against autoimmunity in the periphery, including thymic selection, peripheral induction and the many mechanisms of Treg suppression. Specifically in kidney disease, Tregs have been shown to play a role in limiting injury and may potentially have a therapeutic role.
['Wang|Yuan Min|YM|', 'Ghali|Joanna|J|', 'Zhang|Geoff Yu|GY|', 'Hu|Min|M|', 'Wang|Ya|Y|', 'Sawyer|Andrew|A|', 'Zhou|Jimmy Jianheng|JJ|', 'Hapudeniya|Dhanushka A|DA|', 'Wang|Yiping|Y|', 'Cao|Qi|Q|', 'Zheng|Guoping|G|', 'Harris|David C|DC|', 'Alexander|Stephen I|SI|']
D000818:Animals D015551:Autoimmunity D016207:Cytokines D019175:DNA Methylation D051858:Forkhead Transcription Factors D005921:Glomerulonephritis D006801:Humans D007108:Immune Tolerance D007668:Kidney D008213:Lymphocyte Activation D010641:Phenotype D051436:Renal Insufficiency, Chronic D015398:Signal Transduction D050378:T-Lymphocytes, Regulatory
Tregs autoimmunity Foxp3