Outcome prediction in patients with acute repetitive seizures: Application of the Status Epilepticus Severity Score.
Acute repetitive seizures (ARS) pose a risk of hospital admission with status epilepticus and a mortality threat, which underscores the need for the early prediction of a clinical course. Unfortunately, little attention has been given to ARS in this context, even though we possess the appropriate predictive tools for the stages of status epilepticus. Therefore, the main aim of this study was to assess the prognostic value of the Status Epilepticus Severity Score (STESS) in the population of patients with ARS. The study included a population of 200 patients. Almost half of the patients had achieved seizure cessations after diazepam administration, whereas 19.5% progressed to status epilepticus despite antiepileptic drug treatment. Mortality reached 10.5% of the total population. The receiver operating characteristic (ROC) curve for prediction of death by the STESS had an area under the curve (AUC) of 0.901, with an optimal cutoff point for discrimination ≥2 (sensitivity 0.95, specificity 0.71, and Youden index 0.66). Hosmer-Lemeshow indicated good calibration of the STESS (chi-square goodness-of-fit test = 3.24; P = .919). The study shows excellent effectiveness of the STESS in the prognosis of the clinical course in patients with ARS. STESS may be a valuable tool for the proper planning of diagnostic and therapeutic activities in this population.
['Szklener|Sebastian|S|', 'Godek|Magdalena|M|', 'Korchut|Agnieszka|A|', 'Balicka-Adamik|Luiza|L|', 'Rejdak|Robert|R|', 'Rossetti|Andrea O|AO|', 'Rejdak|Konrad|K|']
D000328:Adult D000927:Anticonvulsants D019540:Area Under Curve D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D011379:Prognosis D012372:ROC Curve D012720:Severity of Illness Index D013226:Status Epilepticus D016896:Treatment Outcome
acute repetitive seizures Status Epilepticus Severity Score cluster seizures