The predicting roles of carcinoembryonic antigen and its underlying mechanism in the progression of coronavirus disease 2019.
BACKGROUND
The coronavirus disease 2019 (COVID-19) has induced a worldwide epidemiological event with a high infectivity and mortality. However, the predicting biomarkers and their potential mechanism in the progression of COVID-19 are not well known.


OBJECTIVE
The aim of this study is to identify the candidate predictors of COVID-19 and investigate their underlying mechanism.


METHODS
The retrospective study was conducted to identify the potential laboratory indicators with prognostic values of COVID-19 disease. Then, the prognostic nomogram was constructed to predict the overall survival of COVID-19 patients. Additionally, the scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of the most important prognostic indicators in lungs and peripherals, respectively.


RESULTS
In total, 304 hospitalized adult COVID-19 patients in Wuhan Jinyintan Hospital were included in the retrospective study. CEA was the only laboratory indicator with significant difference in the univariate (P < 0.001) and multivariate analysis (P = 0.020). The scRNA-seq data of BALF and PBMCs from COVID-19 patients were downloaded to investigate the underlying mechanism of CEA in lungs and peripherals, respectively. The results revealed the potential roles of CEA were significantly distributed in type II pneumocytes of BALF and developing neutrophils of PBMCs, participating in the progression of COVID-19 by regulating the cell-cell communication.


CONCLUSION
This study identifies the prognostic roles of CEA in COVID-19 patients and implies the potential roles of CEACAM8-CEACAM6 in the progression of COVID-19 by regulating the cell-cell communication of developing neutrophils and type II pneumocyte.
['Huang|Runzhi|R|', 'Meng|Tong|T|', 'Zha|Qiongfang|Q|', 'Cheng|Kebin|K|', 'Zhou|Xin|X|', 'Zheng|Junhua|J|', 'Zhang|Dingyu|D|', 'Liu|Ruilin|R|0000-0001-5498-9131']
D000328:Adult D000368:Aged D015415:Biomarkers D001992:Bronchoalveolar Lavage Fluid D000086382:COVID-19 D002272:Carcinoembryonic Antigen D002450:Cell Communication D002681:China D018450:Disease Progression D006760:Hospitalization D006801:Humans D008297:Male D008875:Middle Aged D009504:Neutrophils D049451:Nomograms D011024:Pneumonia, Viral D011237:Predictive Value of Tests D011379:Prognosis D012189:Retrospective Studies D000086402:SARS-CoV-2 D016019:Survival Analysis
Carcinoembryonic antigen Coronavirus disease 2019 Type II pneumocyte Developing neutrophils Carcinoembryonic antigen-related cell adhesion molecules