Alkaloids isolated from Tabernaemontana bufalina display xanthine oxidase inhibitory activity.
Continued interest in bioactive alkaloids led to the isolation of four undescribed alkaloids along with 74 known ones from the aerial parts of Tabernaemontana bufalina Lour. The structures of the yet undescribed alkaloids were elucidated based on NMR, IR, UV, MS and CD spectroscopic data and X-ray crystal diffraction and, according to the plant source, named as taberhaines A-D (1-4). The known compounds comprised of 66 monoterpenoid indole, three carboline and five isoquinoline alkaloids. Among them, the known apparicine inhibited significantly the activity of xanthine oxidase, which plays an important role for gout, with an IC50 value of 0.65 μM, compared to the standard drug allopurinol (IC50 = 0.60 μM).
['Shi|Bao-Bao|BB|', 'Chen|Jing|J|', 'Bao|Mei-Fen|MF|', 'Zeng|Ying|Y|', 'Cai|Xiang-Hai|XH|']
D000470:Alkaloids D020134:Catalytic Domain D004791:Enzyme Inhibitors D020128:Inhibitory Concentration 50 D008958:Models, Molecular D030014:Tabernaemontana D014969:Xanthine Oxidase
Alkaloid Apparicine Taberhaines A–D Tabernaemontana bufalina apocynaceae Xanthine oxidase inhibitor