Influence of delta virus infection on the virologic status in Egyptian patients with chronic hepatitis B virus genotype D.
Hepatitis delta virus (HDV) usually have an unfavorable clinical outcome in chronic hepatitis B virus (HBV) patients. In Egypt, data about epidemiology, the spectrum of disease, and impact of HDV on HBV infection are rare. To assess the prevalence, clinical and virological characteristics of HDV infection among Egyptian patients with chronic HBV. Adult patients with Hepatitis B surface antigen (HBsAg)-positive were evaluated for the presence of HDV using anti HDV-IgG and HDV RNA by RT-PCR. Routine laboratory investigations, genotypes and subtypes for both HBV and HDV, abdominal sonography, and transient elastography (TE) were done. Liver biopsy was performed only in whenever indicated. One hundred and twenty-one treatment-naïve chronic HBV patients were included. Wild HBV genotype-D2 was found in 98.2% and 81.9% were HBeAg negative. Prevalence of HDV was 8.3% by anti-HDV IgG and 9.9% by RT-PCR. Wild HDV genotype-IIb was reported in 83.3%. HDV infection was more common in males, 90.9% of delta patients were HBeAg negative. Compared to the mono-infected HBV, concomitant HBV/HDV infection was not associated with more derangment in ALT nor advanced stage of fibrosis. 66.7% of HDV patients had significantly lower HBV-DNA level compared to the non-delta patients (P < 0.001). HDV is not uncommon in Egypt. HBV genotype-D was associated with HDV genotype-IIb. Delta infection was associated with negative HBeAg status, reduction of HBV replication, but neither influenced the clinical course nor increased significant liver damage risk.
['Fouad|Rabab|R|', 'Abdo|Mahmoud|M|', 'Eldeen|Hadeel Gamal|HG|', 'Sabry|Dina|D|', 'Atef|Mira|M|', 'Ahmed|Rasha|R|', 'Zayed|Naglaa|N|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D001706:Biopsy D060085:Coinfection D003430:Cross-Sectional Studies D004534:Egypt D005260:Female D005838:Genotype D006508:Hepatitis Antibodies D006515:Hepatitis B virus D019694:Hepatitis B, Chronic D019701:Hepatitis D, Chronic D003698:Hepatitis Delta Virus D006801:Humans D007074:Immunoglobulin G D008099:Liver D008297:Male D008875:Middle Aged D015995:Prevalence D012367:RNA, Viral D020133:Reverse Transcriptase Polymerase Chain Reaction D055815:Young Adult
genotype HDV HBV Egypt