Insights on supporting the aging brain microvascular endothelium.
Blood brain barrier hyperpermeability has been associated with age-related affective disorders, including depression, mania, anxiety, Alzheimer's and Parkinson's disease. Our recent efforts suggest that a promising therapeutic approach may arise due to the activation of the unfolded protein response (UPR) element in the affected tissues. Growth hormone releasing hormone antagonists and heat shock protein 90 inhibitors have been shown to induce UPR. This mechanism (UPR) has been associated with tissue repairing processes.
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Blood brain barrier Unfolded protein response Growth hormone releasing hormone P53 Reactive oxygen species