Association between IGF2BP2 Polymorphisms and Type 2 Diabetes Mellitus: A Case-Control Study and Meta-Analysis.
BACKGROUND
Genome-wide association studies (GWAS) found that IGF2BP2 rs4402960 and rs1470579 polymorphisms were associated with type 2 diabetes mellitus (T2DM) risk. Many studies have replicated this association, but yielded inconsistent results.


MATERIALS AND METHODS
A case-control study consisting of 461 T2DM patients and 434 health controls was conducted to detect the genetic susceptibility of IGF2BP2 in a northern Han Chinese population. A meta-analysis was to evaluate the association more precisely in Asians.


RESULTS
In the case-control study, the carriers of TT genotype at rs4402960 had a higher T2DM risk than the G carriers (TG + GG) (adjusted odd ratio (AOR) = 1.962, 95% confidence interval (95% CI) = 1.065-3.612, p = 0.031]; CC carriers at rs1470579 were more susceptible to T2DM than A carriers (CA + AA) (AOR = 2.014, 95% CI = 1.114-3.642, p = 0.021). The meta-analysis containing 36 studies demonstrated that the two polymorphisms were associated with T2DM under the allele comparison, genetic models of dominant and recessive in Asians (p < 0.05). The rs4402960 polymorphisms were significantly associated with the T2DM risk after stratification by diagnostic criterion, size of sample and average age and BMI of cases, while there're no consistent results for rs1470579.


CONCLUSIONS
Our data suggests that IGF2BP2 polymorphisms are associated with T2DM in Asian populations.
['Rao|Ping|P|', 'Wang|Hao|H|', 'Fang|Honghong|H|', 'Gao|Qing|Q|', 'Zhang|Jie|J|', 'Song|Manshu|M|', 'Zhou|Yong|Y|', 'Wang|Youxin|Y|', 'Wang|Wei|W|']
D000328:Adult D044466:Asians D016022:Case-Control Studies D003924:Diabetes Mellitus, Type 2 D005260:Female D005787:Gene Frequency D020022:Genetic Predisposition to Disease D055106:Genome-Wide Association Study D005838:Genotype D006801:Humans D008297:Male D008875:Middle Aged D016017:Odds Ratio D020641:Polymorphism, Single Nucleotide D016601:RNA-Binding Proteins D012306:Risk
IGF2BP2 type 2 diabetes mellitus case-control study meta-analysis Asian