Risk factor profile of calcific aortic stenosis.
BACKGROUND
Calcific aortic stenosis and coronary artery disease share common risk factors. In some of the previous studies statins have been used to retard the progression of aortic stenosis, but the results were inconsistent.


METHODS
One hundred and ten patients of CAS above the age of 40 years have undergone clinical, biochemical and echocardiographic evaluation. Coronary angiograms were done in 66% of them.


RESULTS
Male to female ratio was 2:1. Patients of CAS with CAD showed higher prevalence of diabetes, hypertension, dyslipidemia, smoking and family history of CAD. Prevalence of obesity and bicuspid aortic valve by echocardiogram was high in those without CAD.


CONCLUSIONS
On comparison of prevalence of risk factor in those with and without associated CAD, there was higher prevalence of diabetes (65% vs 30%), hypertension (52% vs 43%), dyslipidemia (69% vs 52%), smoking (24% vs 18%) and family history of CAD (34% vs 16%) in those with associated CAD. The incidence of obesity was higher in those without CAD (20% vs 30%). The difference observed in diabetes alone was found to be statistically significant.
['Sathyamurthy|I|I|', 'Alex|Shaji|S|', 'Kirubakaran|K|K|', 'Sengottuvelu|G|G|', 'Srinivasan|K N|KN|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D001021:Aortic Valve D001024:Aortic Valve Stenosis D002114:Calcinosis D017023:Coronary Angiography D003324:Coronary Artery Disease D004452:Echocardiography D005260:Female D005500:Follow-Up Studies D006801:Humans D015994:Incidence D007194:India D008297:Male D008875:Middle Aged D015995:Prevalence D011446:Prospective Studies D018570:Risk Assessment D012307:Risk Factors D015996:Survival Rate
Coronary artery disease Atherosclerosis Degenerative aortic stenosis