Cancer cells activate damage-tolerant and error-prone DNA synthesis.
Trans-lesion synthesis (TLS) is a DNA damage-tolerant and error-prone mode of DNA replication. Recent work shows that many cancer cells coopt an aberrantly expressed germ cell protein, melanoma antigen-A4 (MAGE-A4), to activate TLS. MAGE-A4-induced "pathological TLS" provides a potential mechanism through which neoplastic cells can tolerate intrinsic and therapeutic genotoxicity while acquiring mutability.
['Mutter-Rottmayer|Elizabeth|E|', 'Gao|Yanzhe|Y|', 'Vaziri|Cyrus|C|']
trans-lesion synthesis (TLS) melanoma antigen-A4 (MAGE-A4) Cancer-testes antigens (CTA) DNA damage RAD18 genome maintenance mutagenesis