Pregnancy outcomes in young mothers with perinatally and behaviorally acquired HIV infections in Rio de Janeiro.
BACKGROUND
Perinatally HIV-infected children are surviving into adulthood, and getting pregnant. There is a scarcity of information on health and pregnancy outcomes in these women.


AIM
To evaluate characteristics related to HIV disease and pregnancy outcomes in perinatally infected women, and to compare these women with a group of youth with behaviorally acquired HIV-infection, at a reference hospital in Rio de Janeiro, Brazil.


METHODS
A cohort study. Epidemiological, clinical, and laboratory data were compared between perinatally (PHIV) and behaviorally HIV-infected (BHIV) pregnant youth with the primary aim to study pregnancy outcomes in the PHIV group and compare with outcomes to BHIV group.


RESULTS
Thirty-two pregnancies occurred in PHIV group, and 595 in BHIV group. A total of seven (22%) PHIV women and 64 (11%) BHIV women had a premature delivery (p=0.04), however, when adjusting for younger age at pregnancy, and antiretroviral therapy initiation in 1st trimester of pregnancy (OR=18.66, 95%CI=5.52-63.14), the difference was no longer significant. No cases of mother-to-child HIV transmission (MTCT) were observed in the PHIV group while there was a 2% MTCT rate in BHIV group.


CONCLUSION
Pregnancy among PHIV was as safe as among BHIV. The differences between those groups were probably related to treatment and prolonged care in the first group.
['Lundberg|Per|P|', 'Andersson|Rune|R|', 'Machado|Elizabeth S|ES|', 'Costa|Tomaz Pinheiro da|TPD|', 'Hofer|Cristina Barroso|CB|']
D000293:Adolescent D000367:Age Factors D023241:Antiretroviral Therapy, Highly Active D001938:Brazil D018791:CD4 Lymphocyte Count D005260:Female D015658:HIV Infections D006801:Humans D018445:Infectious Disease Transmission, Vertical D015999:Multivariate Analysis D011247:Pregnancy D011251:Pregnancy Complications, Infectious D011256:Pregnancy Outcome D011446:Prospective Studies D012307:Risk Factors D047568:Unsafe Sex D019562:Viral Load D055815:Young Adult
Pregnancy Combined antiretroviral treatment Mother-to-child transmission Perinatal HIV