Clinical features of IgG4-related rhinosinusitis.
PURPOSE
IgG4-related disease is a systemic disease that affects various organs of the body. Aim of this study is to elucidate the clinical characteristics of IgG4-related rhinosinusitis.


MATERIAL AND METHODS
Clinical features, laboratory findings, radiological and endoscopic findings, associated disease, treatment and prognosis were retrospectively examined in 10 patients with IgG4-related rhinosinusitis.


RESULTS
The age was 59.1±11.3 years old and male-to-female ratio was 1:1. The chief nasal complaints were hyposmia (n=4), nasal obstruction (n=3), and nothing (n=3). Serum IgG4 levels were elevated in all patients and the value was 740.4±472.4mg/dl. Other IgG4-related diseases were associated in all 10 patients, including IgG4-related sialadenitis (n=6), IgG4-related dacryoadenitis (n=5), and autoimmune pancreatitis (n=5). Imaging findings on CT/MRI were obstruction of the way of elimination (n=10), thickening of the sinus mucous membrane (n=10), and fluid in the sinus (n=6). All of the cases had bilateral findings. Nasal endoscopic findings were chiefly deviated nasal septum (n=5), polyps (n=4), edema of the mucous membrane (n=3). Histologically, abundant infiltration of IgG4 positive plasma cell and lymphocyte and an elevated IgG4+/IgG+ cell ration was detected in all 8 patients and 5 patients, respectively. Endoscopic sinus surgery was performed in 8 patients. Eight patients were treated with steroid therapy for other associated IgG4-related diseases. Symptoms improved in all 6 patients after an initial treatment (endoscopic surgery (n=5) and steroids (n=1)), but one patient suffered relapse.


CONCLUSIONS
IgG4-related rhinosinusitis is a distinct entity of IgG4-related disease, and is associated in patients with multiple IgG4-related diseases.
['Hanaoka|Machiko|M|', 'Kammisawa|Terumi|T|', 'Koizumi|Satomi|S|', 'Kuruma|Sawako|S|', 'Chiba|Kazuro|K|', 'Kikuyama|Masataka|M|', 'Shirakura|Satoshi|S|', 'Sugimoto|Taro|T|', 'Hishima|Tsunekazu|T|']
D000328:Adult D000368:Aged D005260:Female D005500:Follow-Up Studies D006801:Humans D007074:Immunoglobulin G D008297:Male D008875:Middle Aged D011379:Prognosis D012189:Retrospective Studies D012220:Rhinitis D012852:Sinusitis
Rhinosinusitis IgG4-related disease IgG4 Steroid