The transplant cohort of the German center for infection research (DZIF Tx-Cohort): study design and baseline characteristics.
Infectious complications are the major cause of morbidity and mortality after solid organ and stem cell transplantation. To better understand host and environmental factors associated with an increased risk of infection as well as the effect of infections on function and survival of transplanted organs, we established the DZIF Transplant Cohort, a multicentre prospective cohort study within the organizational structure of the German Center for Infection Research. At time of transplantation, heart-, kidney-, lung-, liver-, pancreas- and hematopoetic stem cell- transplanted patients are enrolled into the study. Follow-up visits are scheduled at 3, 6, 9, 12 months after transplantation, and annually thereafter; extracurricular visits are conducted in case of infectious complications. Comprehensive standard operating procedures, web-based data collection and monitoring tools as well as a state of the art biobanking concept for blood, purified PBMCs, urine, and faeces samples ensure high quality of data and biosample collection. By collecting detailed information on immunosuppressive medication, infectious complications, type of infectious agent and therapy, as well as by providing corresponding biosamples, the cohort will establish the foundation for a broad spectrum of studies in the field of infectious diseases and transplant medicine. By January 2020, baseline data and biosamples of about 1400 patients have been collected. We plan to recruit 3500 patients by 2023, and continue follow-up visits and the documentation of infectious events at least until 2025. Information about the DZIF Transplant Cohort is available at https://www.dzif.de/en/working-group/transplant-cohort .
['Karch|André|A|', 'Schindler|Daniela|D|', 'Kühn-Steven|Andrea|A|', 'Blaser|Rainer|R|', 'Kuhn|Klaus A|KA|', 'Sandmann|Lisa|L|', 'Sommerer|Claudia|C|', 'Guba|Markus|M|', 'Heemann|Uwe|U|', 'Strohäker|Jens|J|', 'Glöckner|Stephan|S|', 'Mikolajczyk|Rafael|R|', 'Busch|Dirk H|DH|', 'Schulz|Thomas F|TF|', '|||']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D001424:Bacterial Infections D018070:Biological Specimen Banks D002648:Child D002675:Child, Preschool D015331:Cohort Studies D005260:Female D006801:Humans D007165:Immunosuppression Therapy D008297:Male D008875:Middle Aged D016377:Organ Transplantation D011183:Postoperative Complications D012107:Research Design D055815:Young Adult
Infection Immunosuppression Clinical cohort study Organ transplantation