Annual glycemic variations and risk of cancer among Chinese patients with type 2 diabetes mellitus: A population-based cohort study in Shanghai.
BACKGROUND
Long-term glycemic variation in diabetes patients may have contributed to cancer incidence.


AIM
In this study we aimed at the association between annual glycemic variation and the risk of cancer in Chinese patients with type 2 diabetes mellitus (T2DM).


METHODS
Subjects of this study were from an established population-based cohort of T2DM patients in Minhang District of Shanghai, China. Incident cancer were obtained from the Shanghai Cancer Registry. Glycemic variation was evaluated using the annual fasting glucose coefficient of variation (FG-CV), which was used as a time-dependent variable in a Cox regression model to estimate the associations with the cancer risk. Restricted cubic splines were used to explore potential non-linear associations.


RESULTS
A total of 2,140 incident cancers (1100 men and 1040 women) were identified from the 46,202 diabetes patients during 12-year follow-up. The annual FG-CV remained significantly associated with an increased risk of cancer, even after adjusting for the annual mean FG level. A significant non-linear association was found in male T2DM patients, and a significant linear association in female patients.


CONCLUSIONS
The positive association of the annual FG-CV with the risk of cancer in T2DM patients indicate the importance to stabilize the FG level.
['Xu|Huilin|H|', 'Zhang|Fen|F|', 'Xu|Wanghong|W|', 'Li|Jun|J|', 'Zhu|Jingjing|J|', 'Zhang|Minlu|M|', 'Wu|Zhenyu|Z|', 'Qin|Guoyou|G|']
D000328:Adult D000368:Aged D001786:Blood Glucose D002681:China D015331:Cohort Studies D003924:Diabetes Mellitus, Type 2 D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D009369:Neoplasms D016016:Proportional Hazards Models D012307:Risk Factors D055815:Young Adult
Glycemic variation Cancer Type 2 diabetes mellitus Fasting glucose Time-dependent Cox regression model