The Protective Mechanism of Cannabidiol in Cardiac Injury: A Systematic Review of Non-Clinical Studies.
BACKGROUND
Cardiac disease is accounted as the leading cause of worldwide morbidity and mortality. The disease is characterized by the overproduction of reactive oxygen and/or nitrogen species (ROS/RNS), and induction of oxidative stress. Cannabidiol (CBD) is a non-psychoactive ingredient of marijuana that has been reported to be safe and well tolerated in patients. Due to its pleiotropic effect, CBD has been shown to exert cytoprotective effects. This study intended to clarify the mechanisms and the potential role of CBD regarding cardiac injuries treatment.


METHODS
A systematic literature search was conducted, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, in the electronic databases including PubMed, Web of Science, Scopus, and Embase up to June 2019 using predefined search terms in the titles and abstracts. Accordingly, a set of pre-specified inclusion and exclusion criteria were considered and 8 articles were ultimately included in this study.


RESULTS
Our findings demonstrate that CBD has multi-functional protective assets to improve cardiac injuries; preliminary through scavenging of free radicals, and reduction of oxidative stress, apoptosis, and inflammation.


CONCLUSION
CBD can protect against cardiac injuries, mainly through its antioxidative and antiapoptotic effects on the basis of non-clinical studies. The cardioprotective effects of the CBD need to be further studied in welldesigned clinical trials.
['Shayesteh|Mohammad R H|MRH|', 'Haghi-Aminjan|Hamed|H|', 'Mousavi|Mohammad J|MJ|', 'Momtaz|Saeideh|S|', 'Abdollahi|Mohammad|M|']
D017209:Apoptosis D002185:Cannabidiol D002188:Cannabis D002316:Cardiotonic Agents D016166:Free Radical Scavengers D006331:Heart Diseases D006801:Humans D018384:Oxidative Stress D017382:Reactive Oxygen Species
cardiac injury oxidative stress free radicals cardioprotective effects Cannabinoids systematic review.