Gene editing in dermatology: Harnessing CRISPR for the treatment of cutaneous disease.
The discovery of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system has revolutionized gene editing research. Through the repurposing of programmable RNA-guided CRISPR-associated (Cas) nucleases, CRISPR-based genome editing systems allow for the precise modification of specific sites in the human genome and inspire novel approaches for the study and treatment of inherited and acquired human diseases. Here, we review how CRISPR technologies have stimulated key advances in dermatologic research.  We discuss the role of CRISPR in genome editing for cutaneous disease and highlight studies on the use of CRISPR-Cas technologies for genodermatoses, cutaneous viruses and bacteria, and melanoma. Additionally, we examine key limitations of current CRISPR technologies, including the challenges these limitations pose for the widespread therapeutic application of CRISPR-based therapeutics.
['Baker|Catherine|C|0000-0002-7791-8704', 'Hayden|Matthew S|MS|']
D064113:CRISPR-Cas Systems D064112:Clustered Regularly Interspaced Short Palindromic Repeats D003880:Dermatology D000072669:Gene Editing D015316:Genetic Therapy D006801:Humans D012871:Skin Diseases
gene editing dermatology CRISPR cutaneous disease genodermatoses viruses