CT spectral imaging for monitoring the therapeutic efficacy of VEGF receptor kinase inhibitor AG-013736 in rabbit VX2 liver tumours.
PURPOSE
The aim of this study was to evaluate the value of computed tomography (CT) spectral imaging in assessing the therapeutic efficacy of a vascular endothelial growth factor (VEGF) receptor inhibitor AG-013736 in rabbit VX2 liver tumours.


METHODS
Twenty-three VX2 liver tumour-bearing rabbits were scanned with CT in spectral imaging mode during the arterial phase (AP) and portal phase (PP). The iodine concentrations(ICs)of tumours normalized to aorta (nICs) at different time points (baseline, 2, 4, 7, 10, and 14 days after treatment) were compared within the treated group (n = 17) as well as between the control (n = 6) and treated groups. Correlations between the tumour size, necrotic fraction (NF), microvessel density (MVD), and nICs were analysed.


RESULTS
The change of nICs relative to baseline in the treated group was lower compared to the control group. A greater decrease in the nIC of a tumour at 2 days was positively correlated with a smaller increase in tumour size at 14 days (P < 0.05 for both). The tumour nIC values in AP and PP had correlations with MVD (r = 0.71 and 0.52) and NF (r = -0.54 and -0.51) (P < 0.05 for all).


CONCLUSIONS
CT spectral imaging allows for the evaluation and early prediction of tumour response to AG-013736.


KEY POINTS
• AG-013736 treatment response was evaluated by CT in a rabbit tumour model. • CT spectral imaging allows for the early treatment monitoring of targeted anti-tumour therapies. • Spectral CT findings correlated with vascular changes after anti-tumour therapies. • Spectral CT is a promising method for assessing clinical treatment response.
['Lv|Peijie|P|', 'Liu|Jie|J|', 'Yan|Xiaopeng|X|', 'Chai|Yaru|Y|', 'Chen|Yan|Y|', 'Gao|Jianbo|J|', 'Pan|Yuanwei|Y|', 'Li|Shuai|S|', 'Guo|Hua|H|', 'Zhou|Yue|Y|']
D000818:Animals D000077784:Axitinib D004195:Disease Models, Animal D007093:Imidazoles D007191:Indazoles D008099:Liver D008114:Liver Neoplasms, Experimental D008297:Male D047428:Protein Kinase Inhibitors D011817:Rabbits D040262:Receptors, Vascular Endothelial Growth Factor D015203:Reproducibility of Results D014057:Tomography, X-Ray Computed D016896:Treatment Outcome
CT spectral imaging Liver tumour Computed tomography Animal experience Vascular targeting agent