Stimuli-Responsive Poly(aspartamide) Derivatives and Their Applications as Drug Carriers.
Poly(aspartamide) derivatives, one kind of amino acid-based polymers with excellent biocompatibility and biodegradability, meet the key requirements for application in various areas of biomedicine. Poly(aspartamide) derivatives with stimuli-responsiveness can usually respond to external stimuli to change their chemical or physical properties. Using external stimuli such as temperature and pH as switches, these smart poly(aspartamide) derivatives can be used for convenient drug loading and controlled release. Here, we review the synthesis strategies for preparing these stimuli-responsive poly(aspartamide) derivatives and the latest developments in their applications as drug carriers.
['Zhang|Guangyan|G|0000-0003-1513-0003', 'Yi|Hui|H|', 'Bao|Chenhui|C|']
D001224:Aspartic Acid D003692:Delayed-Action Preparations D004337:Drug Carriers D006863:Hydrogen-Ion Concentration D011108:Polymers D013696:Temperature
stimuli-responsive poly(aspartamide) derivatives drug carrier controlled drug release drug-loading hydrogel nanoparticles polymer-drug conjugate