Migrating into the Tumor: a Roadmap for T Cells.
Tumors can be divided into 'hot' (T cell inflamed) or 'cold' (T cell noninflamed) according to the presence of immune cells. In this review, we discuss variables that influence T cell migration into the tumor microenvironment. Chemokines can attract T cells to the tumor site and tumor intrinsic pathways can influence the composition of local chemokines. Tumor-induced vasculature can hamper T cell migration. Other immune cells and tumor-derived molecules can block T cell proliferation and survival. It is important to better understand these mechanisms in order to target them therapeutically. Enhancing T cell infiltration may increase response rates to immunotherapy and increase survival.
['van der Woude|Lieke L|LL|', 'Gorris|Mark A J|MAJ|', 'Halilovic|Altuna|A|', 'Figdor|Carl G|CG|', 'de Vries|I Jolanda M|IJM|']
D000818:Animals D002465:Cell Movement D049109:Cell Proliferation D006801:Humans D008213:Lymphocyte Activation D051379:Mice D009369:Neoplasms D013601:T-Lymphocytes D013602:T-Lymphocytes, Cytotoxic D059016:Tumor Microenvironment
migration T cells immune cells tumor microenvironment. immunotherapy biomarkers