Acceleration of Long-Range Photoinduced Electron Transfer through DNA by Hydroxyquinolines as Artificial Base Pairs.
The C-nucleoside based on the hydroxyquinoline ligand (Hq) is complementary to itself and forms stable Hq-Hq pairs in double-stranded DNA. These artificial Hq-Hq pairs may serve as artificial electron carriers for long-range photoinduced electron transfer in DNA, as elucidated by a combination of gel electrophoretic analysis of irradiated samples and time-resolved transient absorption spectroscopy. For this study, the Hq-Hq pair was combined with a DNA-based donor-acceptor system consisting of 6-N,N-dimethylaminopyrene conjugated to 2'-deoxyuridine as photoinducible electron donor, and methyl viologen attached to the 2'-position of uridine as electron acceptor. The Hq radical anion was identified in the time-resolved measurements and strand cleavage products support its role as an intermediate charge carrier. Hence, the Hq-Hq pair significantly enhances the electron hopping capability of DNA compared to natural DNA bases over long distances while keeping the self-assembly properties as the most attractive feature of DNA as a supramolecular architecture.
['Bätzner|Effi|E|', 'Liang|Yu|Y|', 'Schweigert|Caroline|C|', 'Unterreiner|Andreas-Neil|AN|', 'Wagenknecht|Hans-Achim|HA|']
D020029:Base Pairing D001483:Base Sequence D004247:DNA D004583:Electrons D006912:Hydroxyquinolines D008969:Molecular Sequence Data D015394:Molecular Structure
electron transfer base pairs transient absorption spectroscopy oligonucleotides photochemistry