A longitudinal study of the effect of ocular biometrics measures on myopia onset.
PURPOSE
To investigate the relationship between ocular biometrics (OB) and myopia onset.


METHODS
OB data from students in 4 grades (aged from 6 to 14 years) in China were collected in a 1.5-year longitudinal study. Refractive error was assessed with cycloplegic autorefraction.


RESULTS
At baseline, 934 (56.33%) of the subjects (right eye) had myopia. The mean spherical equivalent (SE) and axial length to corneal radius (AL/CR) were - 2.14 ± 1.49 and 3.14 ± 0.11, respectively, in the subjects with myopia and - 0.09 ± 0.21 and 2.98 ± 0.07, respectively, in the subjects without myopia. The correlation between the SE and AL/CR was r = - 0.823 (P < 0.001). The slopes of the SE changing with the AL/CR (and R-squares) were - 0.28 to - 1.80 (0.01-0.14) in the no myopia group, - 3.40 to - 6.20 (0.20-0.48) in the low myopia group, and - 3.37 to - 11.34 (0.16-0.74) in the moderate and high myopia groups. The baseline AL/CR values in grades 1, 3, and 5 were higher in those who developed myopia within 1.5 years. The odds ratio of the AL/CR to myopia onset in 1.5 years was 1.096 (95% confidence interval (CI): 1.060-1.135).


CONCLUSIONS
Of the five indicators, the AL/CR showed the best correlation with the SE. The adjoint and linear relationship between the AL/CR and the SE tended to increase with SE progression. When myopia progressed beyond a certain range, the AL/CR was significantly different in those without initial myopia who developed it within 1.5 years compared with those who did not. After adjusting for age, sex, school, and grade, the interpretation capability of the current AL/CR to myopia onset in 1.5 years was limited.
['Tao|Zhengyang|Z|', 'Deng|Hongwei|H|http://orcid.org/0000-0001-8453-8737', 'Zhong|Huahong|H|', 'Yu|Yang|Y|', 'Zhao|Jun|J|', 'Chen|Shuiqiang|S|', 'Li|Shan|S|', 'Zhu|Minjuan|M|']
D000293:Adolescent D058452:Axial Length, Eye D001699:Biometry D002648:Child D005260:Female D006801:Humans D008137:Longitudinal Studies D008297:Male D009216:Myopia D012029:Refraction, Ocular
Longitudinal study Myopia AL/CR Linear Ocular biometry