Cytotoxic phenylpropanoid glycosides from Fagopyrum tataricum (L.) Gaertn.
Fagopyrum tataricum (L.) Gaertn (tartary buckwheat) is an ancient dicotyledonous crop belonging to Polygonaceae family. Besides its benefits for human consumption, tartary buckwheat is also an important folk medicine in China for its antioxidant, antitumour, hypotensive, hypoglycaemic and hypolipidaemic activities. Phytochemical investigation of the ethyl acetate fraction of tartary buckwheat roots led to the isolation of seven new phenylpropanoid glycosides, tatarisides A-G (1-7), together with a known phenylpropanoid glycoside, diboside A (8). Their structures were elucidated by means of spectroscopic methods. All compounds (1-8) were evaluated for their cytotoxic activity against four human cancer cell lines (A-549, HCT116, ZR-75-30 and HL-60). Tatariside C (3) was the most active compound with IC50 values of 6.44-7.49μg/ml against the four tested cell lines.
['Zheng|Chengjian|C|', 'Hu|Changling|C|', 'Ma|Xueqin|X|', 'Peng|Cheng|C|', 'Zhang|Hong|H|', 'Qin|Luping|L|']
D000146:Acids, Carbocyclic D000972:Antineoplastic Agents, Phytogenic D000975:Antioxidants D045744:Cell Line, Tumor D002681:China D004365:Drugs, Chinese Herbal D019612:Fagopyrum D006027:Glycosides D006801:Humans D018517:Plant Roots D010946:Plants, Medicinal
Phenylpropanoid glycosides Fagopyrum tataricum (L.) Gaertn Cytotoxic activity Tatarisides A–G