Predictors of Failure in Fast-Track Cardiac Surgery.
OBJECTIVES
Fast-track (FT) management of cardiac surgery patients is associated with early extubation and reduced length of intensive care unit (ICU) stay, with potential benefit of reduced hospital costs. The authors examined perioperative factors and their influence on failure of FT and what implications this failure had.


DESIGN
Prospective data collection from all adult cardiac surgeries between 2011 and 2013.


SETTING
Single-institution study.


PARTICIPANTS
The study included 2,770 consecutive adult cardiac surgery patients.


INTERVENTIONS
All participants underwent adult cardiac surgeries. Of those, 451 (16.3%) patients were selected to undergo FT management.


MEASUREMENTS AND MAIN RESULTS
Failure of FT was defined as early (admission to ICU on day of surgery) or late (patients later admitted to the ICU from the ward). Univariate and multivariate regression analyses were used to identify which variables predicted FT failure. Of the 451 patients included in this study, 138 (30.6%) failed the FT, with 115 (83.3%) early failures and 23 (16.7%) late failures. Predictors of failure were reduced renal function, hypertension, age, EuroSCORE, cardiopulmonary bypass time, first lactate or base deficit after surgery (all p<0.01), and cross-clamp time (p<0.05). Multivariate analysis showed that the strongest predictor of failure was glomerular filtration rate (GFR)<65 mL/min/BSA (sensitivity, 54%; specificity, 61%; likelihood ratio, 1.39; area under receiver operating characteristics curve, 0.59; 95% confidence interval, 0.53-0.64). Median length of hospital stay was longer for the failed group (5 v 7 days, p<0.001). There were no mortalities in any of the patients selected for FT.


CONCLUSIONS
A number of perioperative factors are associated with failure to FT, the strongest predictor being GFR. Failure to FT can lead to significantly longer hospital stay.
['Youssefi|Pouya|P|', 'Timbrell|David|D|', 'Valencia|Oswaldo|O|', 'Gregory|Peter|P|', 'Vlachou|Caterina|C|', 'Jahangiri|Marjan|M|', 'Edsell|Mark|M|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D006348:Cardiac Surgical Procedures D005260:Female D005919:Glomerular Filtration Rate D006801:Humans D007902:Length of Stay D008297:Male D008875:Middle Aged D011182:Postoperative Care D011183:Postoperative Complications D011237:Predictive Value of Tests D011300:Preoperative Care D011446:Prospective Studies D013997:Time Factors D017211:Treatment Failure D055815:Young Adult
fast-track cardiac surgery glomerular filtration rate postoperative care