HLA-A*24:07 as a potential biomarker for carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Filipino patients.
Aim: A case-control study was conducted in Filipino patients to determine the association between HLA alleles and carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). Materials & methods: A retrospective review of medical records and data collection were performed. A total of 10 carbamazepine-induced SJS/TEN cases and 40 tolerant controls were recruited. Genomic DNA extracted from saliva samples was genotyped. Statistical analysis was done. Results: The HLA-B75 serotype (p = 0.003; odds ratio [OR] = 13.8; 95% CI = 2.5-76.8), HLA-B*15:21 (p = 0.041; OR = 4.7; 95% CI = 1.1-20.8) and HLA-A*24:07 (p = 0.032; OR = 6; 95% CI = 1.2-30.7) were significantly associated with carbamazepine-induced SJS/TEN. Conclusion: The HLA-B75 serotype, HLA-B*15:21 or HLA-A*24:07 may be used for pharmacogenetic screening prior to prescribing carbamazepine in Filipinos.
['Capule|Francis|F|0000-0003-2468-9095', 'Tragulpiankit|Pramote|P|0000-0002-0832-6860', 'Mahasirimongkol|Surakameth|S|0000-0002-7555-1056', 'Jittikoon|Jiraphun|J|0000-0003-4987-3497', 'Wichukchinda|Nuanjun|N|0000-0002-9801-3111', 'Alentajan-Aleta|Lara Theresa|LT|', 'Barit|Jay-V James|JJ|0000-0003-4801-9782', 'Casanova-Gutierrez|Josephine|J|', 'Cabral-Lim|Leonor|L|0000-0002-7523-4165', 'Baltazar Reyes|Jose Paciano|JP|0000-0002-4672-6320', 'Roa|Francisca|F|0000-0002-8871-4213', 'Salonga|Raymark|R|0000-0002-3194-507X', 'San Gabriel|Katrina Faith|KF|', 'Silao|Catherine Lynn|CL|0000-0001-9739-6168']
HLA-A*24:07 toxic epidermal necrolysis Filipino HLA-B75 serotype HLA-B*15:21 carbamazepine Stevens–Johnson syndrome antiepileptic agent human leukocyte antigen severe cutaneous adverse drug reactions