Near-critical GLUT1 and Neurodegeneration.
Recent articles have drawn renewed attention to the housekeeping glucose transporter GLUT1 and its possible involvement in neurodegenerative diseases. Here we provide an updated analysis of brain glucose transport and the cellular mechanisms involved in its acute modulation during synaptic activity. We discuss how the architecture of the blood-brain barrier and the low concentration of glucose within neurons combine to make endothelial/glial GLUT1 the master controller of neuronal glucose utilization, while the regulatory role of the neuronal glucose transporter GLUT3 emerges as secondary. The near-critical condition of glucose dynamics in the brain suggests that subtle deficits in GLUT1 function or its activity-dependent control by neurons may contribute to neurodegeneration. © 2017 Wiley Periodicals, Inc.
['Barros|L Felipe|LF|', 'San Martín|Alejandro|A|', 'Ruminot|Ivan|I|', 'Sandoval|Pamela Y|PY|', 'Fernández-Moncada|Ignacio|I|', 'Baeza-Lehnert|Felipe|F|', 'Arce-Molina|Robinson|R|', 'Contreras-Baeza|Yasna|Y|', 'Cortés-Molina|Francisca|F|', 'Galaz|Alex|A|', 'Alegría|Karin|K|']
D000818:Animals D001921:Brain D004734:Energy Metabolism D005947:Glucose D051272:Glucose Transporter Type 1 D006801:Humans D019636:Neurodegenerative Diseases D009474:Neurons
glucose transporter Alzheimer disease GLUT1 deficiency Slc2a1 astrocyte endothelium