Baclofen effects on alcohol seeking, self-administration and extinction of seeking responses in a within-session design in baboons.
Baclofen, a gamma-aminobutyric acidB receptor agonist, is currently under investigation as a potential treatment to prevent relapse to drinking in alcohol-dependent persons. In the current study, two groups of baboons were trained under a chained schedule of reinforcement (CSR), with three linked components, which were each correlated with different response requirements and cues. Fulfilling the requirement in the second link initiated the third link where either alcohol (n = 4) or a preferred non-alcoholic beverage (Tang, n = 5) was available for self-administration; failure to complete the response requirement in Link 2 ended the session (no access to alcohol or Tang). Seeking responses in Link 2 were used as indices of the motivational processes thought to be involved in relapse. The effects of baclofen (0.1-2.4 mg/kg) were examined under conditions with alcohol or Tang access and under extinction. Under the CSR, baclofen (1.8 and 2.4 mg/kg) significantly decreased (P < 0.05) alcohol self-administration responses and total g/kg alcohol intake. In contrast, only the highest dose of baclofen (2.4 mg/kg) reduced Tang self-administration and consumption. Under within-session extinction conditions, baclofen (1.8 and 2.4 mg/kg) facilitated extinction of responding for both alcohol and Tang, particularly during the first 10 minutes of extinction. Baclofen may be effective in reducing craving and alcohol drinking, although the facilitation of extinction and suppression of both alcohol and Tang self-administration by baclofen suggests these effects may be related to a more general suppression of consummatory and conditioned behaviors.
['Duke|Angela N|AN|', 'Kaminski|Barbara J|BJ|', 'Weerts|Elise M|EM|']
D000328:Adult D000428:Alcohol Drinking D000704:Analysis of Variance D000818:Animals D001418:Baclofen D003216:Conditioning, Operant D003463:Cues D004195:Disease Models, Animal D004305:Dose-Response Relationship, Drug D004327:Drinking Behavior D058999:Drug-Seeking Behavior D000431:Ethanol D005108:Extinction, Psychological D058786:GABA-B Receptor Agonists D006801:Humans D008297:Male D010215:Papio D012055:Reinforcement Schedule D055502:Secondary Prevention D012646:Self Administration
baclofen Alcohol extinction reinforcement drug-seeking non-human primate