miR-429 is involved in regulation of NF-κBactivity by targeting IKKβ and suppresses oncogenic activity in cervical cancer cells.
Dysregulation of microRNAs (miRNAs) can contribute to tumorigenesis in cancers. In this study, we found that miR-429 was downregulated in cervical cancer (CC) tissues and suppressed cell viability and proliferation while promoting apoptosis in CC cells. IKKβ was a novel target gene of miR-429 and ectopic expression of IKKβ abrogated the phenotypes induced by miR-429. When IKKβ was downregulated by miR-429, nuclear factor κB (NF-κB) pathway activation, interleukin-6 (IL-6), and interferon-β (IFN-β) production were decreased in CC cells. These findings indicate that miR-429 is involved in regulation of the NF-κB pathway by targeting IKKβ and functions as a tumor suppressor in cervical carcinogenesis.
['Fan|Jing-Yi|JY|', 'Fan|Ya-Jie|YJ|', 'Wang|Xiang-Ling|XL|', 'Xie|Hong|H|', 'Gao|Hui-Jie|HJ|', 'Zhang|Yi|Y|', 'Liu|Min|M|', 'Tang|Hua|H|']
D017209:Apoptosis D001483:Base Sequence D063646:Carcinogenesis D045744:Cell Line, Tumor D049109:Cell Proliferation D002470:Cell Survival D015536:Down-Regulation D005260:Female D015972:Gene Expression Regulation, Neoplastic D006801:Humans D051550:I-kappa B Kinase D016899:Interferon-beta D015850:Interleukin-6 D035683:MicroRNAs D016328:NF-kappa B D002583:Uterine Cervical Neoplasms
miR-429 IKKβ cervical cancer NF-κB