Long-term sequelae treatment of peripheral facial paralysis with botulinum toxin type A: Repartition and kinetics of doses used.
STUDY OBJECTIVES
Botulinum toxin is a key therapeutic tool in the comprehensive treatment of peripheral facial paralysis. It fights spasms, synkinesis and overactivity of the different skin muscles responsible of facial expressions. Even though injection techniques as well as target muscles have been well identified, doses used remain quite imprecise and often not detailed muscle by muscle, further more dosage progression has not been monitored over time. Our retrospective study is the first one to refine the repartition of botulinum toxin doses on each of the relevant skin muscles and assess dosage kinetics.


PATIENTS AND METHODS
Thirty patients were included since 2008 with a mean follow-up of 2.3years. Each patient had at least 3 injections, with a delay of 4 to 6months between each injection.


RESULTS
Mean doses are indicated for each muscle injected on the paralyzed and healthy sides. Dose kinetics suggests an initial dosage increase after the first injection followed by a decrease over time. No treatment resistance was observed.


CONCLUSION
Our study represents a didactic help in using botulinum toxin for sequelae of peripheral facial paralysis by providing more details on the effective mean doses for each muscle and their progression over time.
['Risoud|M|M|', 'Aljudaibi|N|N|', 'Duquennoy-Martinot|V|V|', 'Guerreschi|P|P|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D000818:Animals D019274:Botulinum Toxins, Type A D002648:Child D004305:Dose-Response Relationship, Drug D004334:Drug Administration Schedule D005152:Facial Muscles D005158:Facial Paralysis D005260:Female D005500:Follow-Up Studies D006801:Humans D008297:Male D008875:Middle Aged D051381:Rats D012189:Retrospective Studies D016896:Treatment Outcome
Botulinum toxin Kinetics Dosage Cinétique Facial palsy Paralysie faciale Posologies Toxine botulique