A phase I, open-label, two-stage study to investigate the safety, tolerability, pharmacokinetics, and pharmacodynamics of the oral AKT inhibitor GSK2141795 in patients with solid tumors.
Background We sought to determine the recommended phase II dose (RP2D) and schedule of GSK2141795, an oral pan-AKT kinase inhibitor. Patients and Methods Patients with solid tumors were enrolled in the dose-escalation phase. Pharmacokinetic (PK) analysis after a single dose (Cycle 0) informed dose escalation using accelerated dose titration. Once one grade 2 toxicity or dose-limiting toxicity was observed in Cycle 1, the accelerated dose titration was terminated and a 3 + 3 dose escalation was started. Continuous daily dosing was evaluated along with two intermittent regimens (7 days on/7 days off and 3 times per week). In the expansion phase at RP2D, patients with endometrial or prostate cancer, as well as those with select tumor types with a PIK3CA mutation, AKT mutation or PTEN loss, were enrolled. Patients were evaluated for adverse events (AEs), PK parameters, blood glucose and insulin levels, and tumor response. Results The RP2D of GSK2141795 for once-daily dosing is 75 mg. The most common (>10%) treatment-related AEs included diarrhea, fatigue, vomiting, and decreased appetite. Most AEs were low grade. The frequency of hyperglycemia increased with dose; however, at the RP2D, grade 3 hyperglycemia was only reported in 4% of patients and no grade 4 events were observed. PK characteristics were favorable, with a prolonged half-life and low peak-to-trough ratio. There were two partial responses at the RP2D in patients with either a PIK3CA mutation or PTEN loss. Conclusion GSK2141795 was safe and well-tolerated, with clinical activity seen as monotherapy at the RP2D of 75 mg daily. NCT00920257.
['Aghajanian|Carol|C|', 'Bell-McGuinn|Katherine M|KM|', 'Burris|Howard A|HA|', 'Siu|Lillian L|LL|', 'Stayner|Lee-Ann|LA|', 'Wheler|Jennifer J|JJ|', 'Hong|David S|DS|', 'Kurkjian|Carla|C|', 'Pant|Shubham|S|', 'Santiago-Walker|Ademi|A|', 'Gauvin|Jennifer L|JL|', 'Antal|Joyce M|JM|', 'Opalinska|Joanna B|JB|', 'Morris|Shannon R|SR|', 'Infante|Jeffrey R|JR|']
D000284:Administration, Oral D000328:Adult D000368:Aged D000369:Aged, 80 and over D015331:Cohort Studies D003959:Diamines D004305:Dose-Response Relationship, Drug D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D009154:Mutation D009369:Neoplasms D047428:Protein Kinase Inhibitors D051057:Proto-Oncogene Proteins c-akt D011720:Pyrazoles
Akt GSK2141795 PTEN Endometrial cancer PIK3