Oral Intake of Carboxymethyl-Glucan (CM-G) from Yeast (Saccharomyces uvarum) Reduces Malondialdehyde Levels in Healthy Men.
Carboxymethyl-glucan (CM-G) is a water-soluble derivative of β(1 → 3)(1 → 6) glucan, a well-known immunostimulant and antioxidant compound. In this experimental, randomized and placebo-controlled study, the effects of oral CM-G intake over a 60-day period on the peripheral blood, cholesterol, glycemic index and malondialdehyde (MDA) levels of healthy men was assessed. The CM-G was obtained from spent brewer's yeast (S. uvarum) with DS 0.8 and molecular weight of 2.2 × 10(5) Da. Following CM-G administration, no changes were observed in red and white blood cell, hematocrit, hemoglobin and platelet counts, or in cholesterol and glycemic indices. After 30 days of CM-G administration, the MDA levels decreased significantly (p ≤ 0.05) in men receiving CM-G. The results showed for the first time that CM-G may act as an adjuvant in preventing oxidative damage in healthy humans.
['Araújo|Vilma Barbosa da Silva|VB|', 'de Melo|Adma Nadja Ferreira|AN|', 'de Souza|Neyrijane Targino|NT|', 'da Silva|Vânia Maria Barboza|VM|', 'Castro-Gomez|Raul H|RH|', 'Silva|Alexandre Sérgio|AS|', 'de Souza|Evandro Leite|EL|', 'Magnani|Marciane|M|']
D000284:Administration, Oral D000328:Adult D002452:Cell Count D006262:Health D006801:Humans D008297:Male D008315:Malondialdehyde D012440:Saccharomyces D047071:beta-Glucans
carboxymethyl-glucan malondialdehyde blood cells glucan-derivatives