Orthopedic implant biomaterials with both osteogenic and anti-infection capacities and associated in vivo evaluation methods.
Osteogenicity (i.e., properties that promote new bone formation on and around the implant) has long been a clinical requirement for most orthopedic implants. Recently, anti-infection or antibacterial properties have become critical for orthopedic implants (especially without the use of antibiotics). Ideally, orthopedic implant materials with simultaneous anti-infection and osteogenic capacities are extremely promising for orthopedic applications, but such materials are not widely available to date and have only recently been researched. In the first part of this review, numerous attractive material formulations that exhibit both antibacterial and osteogenic capacities as well as surface modification strategies that enhance such capacities are introduced. Several possible mechanisms underlying simultaneous antibacterial and osteogenic properties are also discussed. In the second part of this review, evaluation methods including animal models, analytical tools and available guidelines for assessing antibacterial and osteogenic properties of implantable materials in vivo are summarized and discussed.
['Lin|Xiao|X|', 'Yang|Shaofeng|S|', 'Lai|Kalyn|K|', 'Yang|Huilin|H|', 'Webster|Thomas J|TJ|', 'Yang|Lei|L|']
D000497:Alloys D000818:Animals D000900:Anti-Bacterial Agents D002516:Ceramics D020099:Coated Materials, Biocompatible D006801:Humans D010012:Osteogenesis D019736:Prostheses and Implants D013499:Surface Properties
Orthopedic implants Osteogenicity In vivo evaluation Anti-bacterial Infection