Development of depression in patients with oral cavity cancer: a systematic review.
BACKGROUND
The incidence of oral cancer is approximately 300,000 patients annually. A cancer diagnosis and treatment affect both physical and mental issues.


OBJECTIVES
The aim of this systematic review was to examine the development of depression in patients who have been treated for oral squamous cell carcinoma (OSCC).


MATERIAL AND METHODS
PubMed and EMBASE were systematically searched for studies addressing depression among patients treated for OSCC and published within the past ten years.


RESULTS
We identified three studies comprising 528 patients (range: 75-349), primarily men (66-83%), treated for OSCC from Europe and India. Tumour stage, treatment modality, and scales used to evaluate depressive symptoms varied in the studies. The European studies showed that 28% of the patients experienced depressive symptoms on the Hospital Anxiety and Depression Scale (HADS) and a mean of 8.0 on depression in the Brief Symptom Inventory (BSI). The Indian study showed a significant increase (p Value < .001) from moderate to severe depressive symptoms on the Depression, Anxiety, and Stress Scale-21 (DASS-21).Conclusion and Significance: This systematic review showed that OSCC patients are at risk of developing depressive symptoms after treatment, though severity of symptoms varied. This knowledge could preferably be implemented in future follow-up regimes.
['Lansner|Mira Westphal|MW|', 'Jakobsen|Kathrine Kronberg|KK|http://orcid.org/0000-0003-0336-5411', 'Jensen|Jakob Schmidt|JS|http://orcid.org/0000-0002-6636-6924', 'Sandsten|Karl Erik|KE|', 'Grønhøj|Christian|C|', 'von Buchwald|Christian|C|http://orcid.org/0000-0001-6753-8129']
D003863:Depression D006801:Humans D009062:Mouth Neoplasms D012307:Risk Factors
depression oral cavity cancer Systematic review oral squamous cell carcinoma OSCC depressive symptoms after treatment