Assessment of mineral and bone biomarkers highlights a high frequency of hypercalciuria in asymptomatic healthy teenagers.
AIM
Assessment of mineral metabolism is complex in paediatrics.


METHODS
We assessed the evolution of the main mineral and bone biomarkers (total/bone alkaline phosphatase ALP/BAP, β-crosslaps, osteocalcin, sclerostin, C-terminal and intact FGF23) in 100 healthy teenagers (10-18 years, 50 boys).


RESULTS
At a mean age of 13.7 ± 2.2 years, phosphatemia, tubular phosphate reabsorption, ALP and BAP significantly decreased along puberty in both genders, whilst parathyroid hormone (PTH), 25-vitamin D (25D), FGF23, plasma calcium and urinary calcium were not modified. In girls, osteocalcin, β-crosslaps and sclerostin significantly decreased at the end of puberty. Calciuria above the crystallisation threshold (>3.8 mmol/L) and urinary calcium/creatinine ratio >0.7 mmol/mmol were found in 39% and 6% of subjects, respectively. Multivariable analyses showed that renal function and PTH were significant predictors of calciuria and urinary calcium/creatinine, whilst 25D remained a predictor only of urinary calcium/creatinine ratio.


CONCLUSION
Using the most recent assays, this study provides data for mineral/bone biomarkers across puberty and highlights the risk of hyper-calciuria in apparent asymptomatic healthy teenagers, not related to calcium intake but rather to 25D. Future studies are required to dissect the underlying mechanisms increasing calciuria and prevent nephrolithiasis as early as during childhood.
['Bacchetta|Justine|J|0000-0002-0578-2529', 'Ginhoux|Tiphanie|T|', 'Bernoux|Delphine|D|', 'Dubourg|Laurence|L|', 'Ranchin|Bruno|B|', 'Roger|Christelle|C|']
D000293:Adolescent D015415:Biomarkers D001842:Bone and Bones D002118:Calcium D002648:Child D003430:Cross-Sectional Studies D005260:Female D000089703:Fibroblast Growth Factor-23 D006801:Humans D053565:Hypercalciuria D008297:Male D010710:Phosphates D012016:Reference Values D014807:Vitamin D
bone biomarkers healthy teenagers puberty calciuria