Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: friends or foes?
Chemokines are critical components in pathology. The roles of chemokine CC motif ligand 4 (CCL4) and its receptor are associated with diabetes mellitus (DM) and atherosclerosis cardiovascular diseases. However, due to the complexity of these diseases, the specific effects of CCL4 remain unclear, although recent reports have suggested that multiple pathways are related to CCL4. In this review, we provide an overview of the role and potential mechanisms of CCL4 and one of its major receptors, fifth CC chemokine receptor (CCR5), in DM and cardiovascular diseases. CCL4-related mechanisms, including CCL4 and CCR5, might provide potential therapeutic targets in DM and/or atherosclerosis cardiovascular diseases.
['Chang|Ting-Ting|TT|', 'Chen|Jaw-Wen|JW|']
D000818:Animals D002317:Cardiovascular Agents D002318:Cardiovascular Diseases D054407:Chemokine CCL4 D048909:Diabetes Complications D003922:Diabetes Mellitus, Type 1 D003924:Diabetes Mellitus, Type 2 D006801:Humans D007004:Hypoglycemic Agents D008024:Ligands D019713:Receptors, CCR5 D015398:Signal Transduction
Chemokine Chemokine CC motif ligand 4 Diabetes mellitus Cardiovascular disease Fifth CC chemokine receptor