Evaluation of the safety and effectiveness of an alternative dural substitute using porcine pericardium for duraplasty in a large animal model.
This study aimed to evaluate the safety and effectiveness of an alternative dural substitute using a porcine pericardial graft for duraplasty in a large animal model. Six pigs underwent bilateral craniectomy followed by bilateral duraplasty using either a porcine pericardium patch or a Biodesign® Dural Repair Graft. Intraoperative workability was evaluated for each type of graft. Pigs were euthanized after 1 and 3 months (n = 3 per group). Histological analysis was performed for each case. The Biodesign® Dural Repair Graft showed better workability than the porcine pericardial patch, which was more transparent (p = 0.002). Histological analyses at 1 and 3 months showed no differences between the types of graft. There was no postoperative leakage of cerebrospinal fluid in any case. No grafts showed any adverse reactions in the underlying brain tissues. The porcine pericardial patch as a dural substitute seems to be an acceptable alternative graft to duraplasty using a small intestinal submucosal graft (Biodesign®). Further studies are needed to determine whether porcine pericardial patches provide workable alternatives in clinical practice.
['Seo|Youngbeom|Y|', 'Kim|Jin Wook|JW|', 'Dho|Yun Sik|YS|', 'Chowdhury|Tamrin|T|', 'Kim|Sojin|S|', 'Park|Chul-Kee|CK|']
D000818:Animals D001688:Biological Products D003399:Craniotomy D004195:Disease Models, Animal D004388:Dura Mater D007421:Intestine, Small D008297:Male D010496:Pericardium D019651:Reconstructive Surgical Procedures D013552:Swine D016896:Treatment Outcome
Dural substitute Porcine pericardium Xenograft