Role of Neutrophils on the Ocular Surface.
The ocular surface is a gateway that contacts the outside and receives stimulation from the outside. The corneal innate immune system is composed of many types of cells, including epithelial cells, fibroblasts, natural killer cells, macrophages, neutrophils, dendritic cells, mast cells, basophils, eosinophils, mucin, and lysozyme. Neutrophil infiltration and degranulation occur on the ocular surface. Degranulation, neutrophil extracellular traps formation, called NETosis, and autophagy in neutrophils are involved in the pathogenesis of ocular surface diseases. It is necessary to understand the role of neutrophils on the ocular surface. Furthermore, there is a need for research on therapeutic agents targeting neutrophils and neutrophil extracellular trap formation for ocular surface diseases.
['Mun|Yongseok|Y|0000-0003-0123-0361', 'Hwang|Jin Sun|JS|', 'Shin|Young Joo|YJ|0000-0003-4307-7000']
D015550:Cell Degranulation D003315:Cornea D065206:Extracellular Traps D005128:Eye Diseases D006801:Humans D020556:Neutrophil Infiltration D009504:Neutrophils
neutrophil neutrophil extracellular trap ocular surface disease dry eye syndrome