The role of surgical intervention for isolated breast cancer liver metastasis: Results of case-control study with comparison to medical treatment.
BACKGROUND
Combined with systemic therapy, the surgical intervention for breast cancer liver metastases (BCLM) is increasingly accepted but lacks convincing evidence. The aim of this study was to evaluate the disease control efficacy of hepatic surgery in isolated BCLM patients.


METHODS
Between 2012 and 2017, metastatic breast cancer patients with isolated liver metastasis and regular follow-up were identified. Cohort design was conducted to compare the progression-free survival (PFS) between the surgical and nonsurgical BCLM patients. Univariate analysis and multivariate Cox regression survival analyses were performed to identify significant prognostic factors.


RESULT
In all, 148 isolated BCLM patients were enrolled and 95 participants received hepatic surgery for metastatic lesions. With median follow-up of 36.47 months, there was no significant difference between hepatic surgical group and nonsurgical group for PFS (median PFS: 11.17 months vs 10.10 m, P = .092). Based on the multivariate analysis, the disease-free interval (DFI) was an independent prognostic factor for isolated BCLM patients. Among the surgical group, BCLM patients who had ideal response after first salvage systemic treatment experienced the best long-term survival (median PFS: 14.20 months).


CONCLUSION
For isolated BCLM patients with ideal response in first-line medical treatment, surgical intervention (hepatectomy, radiofrequency ablation) combining with systemic treatment could bring improved progression-free survival compared to sole systemic treatment, indicating that hepatic surgery may be considered as a therapeutic choice for selected isolated BCLM patients in clinical practice.
['Wen|Jiahuai|J|0000-0001-7326-5980', 'Ye|Feng|F|', 'Xie|Fengfeng|F|', 'Liu|Dan|D|', 'Huang|LeZhen|L|', 'Fang|Chen|C|', 'Zhong|Shaowen|S|', 'Ren|Liping|L|']
D000328:Adult D000970:Antineoplastic Agents D001943:Breast Neoplasms D016022:Case-Control Studies D018572:Disease-Free Survival D005260:Female D006498:Hepatectomy D006801:Humans D008113:Liver Neoplasms D008875:Middle Aged D000077982:Progression-Free Survival D000078703:Radiofrequency Ablation D012044:Regression Analysis D012189:Retrospective Studies D016879:Salvage Therapy
surgical intervention breast cancer liver metastasis