Intensity-modulated Radiotherapy in Patients With Aggressive Extranodal Non-Hodgkin Lymphoma of the Head and Neck.
BACKGROUND/AIM
Image-guided intensity-modulated radiotherapy (IG-IMRT) is increasingly being used to treat patients with head and neck malignancies. This analysis compared conventional radiotherapy (CRT) and IMRT outcomes for head and neck aggressive extranodal non-Hodgkin lymphomas (EN-NHL).


PATIENTS AND METHODS
Forty-eight patients who underwent irradiation between 2005 and 2019 were identified.


RESULTS
The median follow-up was 42 months. Patients treated with IMRT experienced higher overall responde rate than patients who received 3DCRT (85% vs. 73%, p=0.4). There was non-significant longer survival following IMRT compared with 3DCRT in terms of 5-year OS (p=0.16). Complete responders after primary treatments had a significantly higher 5-year progression-free (p<0.001) and overall survival (p=0.003) in comparison with those without a complete response. Regarding toxicities, IMRT was associated with less acute and chronic adverse events.


CONCLUSION
IG-IMRT following systemic therapy seems to be associated with a favorable survival and toxicity profile in patients with EN-NHL.
['Eismann|Jens|J|', 'Elsayad|Khaled|K|', 'Rolf|Daniel|D|', 'Sarif|Iqbal|I|', 'Wardelmann|Eva|E|', 'Berssenbrügge|Hendrik|H|', 'Lenz|Georg|G|', 'Eich|Hans Theodor|HT|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D005260:Female D005500:Follow-Up Studies D006258:Head and Neck Neoplasms D006801:Humans D008228:Lymphoma, Non-Hodgkin D008297:Male D008875:Middle Aged D011379:Prognosis D011879:Radiotherapy Dosage D011880:Radiotherapy Planning, Computer-Assisted D061089:Radiotherapy, Image-Guided D050397:Radiotherapy, Intensity-Modulated D012189:Retrospective Studies D015996:Survival Rate
IMRT Extranodal lymphoma image-guided radiotherapy immunotherapy local control prognosis