Pretreatment texture analysis of routine MR images and shape analysis of the diffusion tensor for prediction of volumetric response after radiosurgery for meningioma.
OBJECTIVEThe goal of this study was to identify parameters from routine T1- and T2-weighted MR sequences and diffusion tensor imaging (DTI) that best predict the volumetric changes in a meningioma after treatment with Gamma Knife radiosurgery (GKRS).METHODSIn 32 patients with meningioma, routine MRI and DTI data were measured before GKRS. A total of 78 parameters derived from first-level texture analysis of the pretreatment MR images, including calculation of the mean, SD, 2.5th and 97.5th percentiles, and kurtosis and skewness of data in histograms on a voxel-wise basis, were correlated with lesion volume change after a mean follow-up period of 3 years (range 19.5-63.3 months).RESULTSSeveral DTI-derived parameters correlated significantly with a meningioma volume change. The parameter that best predicted the results of GKRS was the 2.5th percentile value of the smallest eigenvalue (L3) of the diffusion tensor (correlation coefficient 0.739, p ≤ 0.001), whereas among the non-DTI parameters, only the SD of T2-weighted images correlated significantly with a tumor volume change (correlation coefficient 0.505, p ≤ 0.05, after correction for family-wise errors using false-detection-rate correction).CONCLUSIONSDTI-derived data had a higher correlation to shrinkage of meningioma volume after GKRS than data from T1- and T2-weighted image sequences. However, if only routine MR images are available, the SD of T2-weighted images can be used to predict control or possible progression of a meningioma after GKRS.
['Speckter|Herwin|H|', 'Bido|Jose|J|', 'Hernandez|Giancarlo|G|', 'Rivera|Diones|D|', 'Suazo|Luis|L|', 'Valenzuela|Santiago|S|', 'Miches|Isidro|I|', 'Oviedo|Jairo|J|', 'Gonzalez|Cesar|C|', 'Stoeter|Peter|P|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D005500:Follow-Up Studies D006801:Humans D007090:Image Interpretation, Computer-Assisted D008279:Magnetic Resonance Imaging D008577:Meningeal Neoplasms D008579:Meningioma D008875:Middle Aged D011379:Prognosis D016634:Radiosurgery D012189:Retrospective Studies D047368:Tumor Burden
texture analysis meningioma diffusion tensor imaging Gamma Knife CC = correlation coefficient CE = contrast enhanced Cl = longitudinal index Cp = planar index Cs = spherical index DTI = diffusion tensor imaging FA = fractional anisotropy GKRS = Gamma Knife radiosurgery SK = skewness of tensor shape SRS = stereotactic radiosurgery oncology stereotactic radiosurgery