Tau immunotherapy for Alzheimer's disease.
Targeting pathological tau protein in Alzheimer's disease (AD) and related tauopathies has shown great potential in animal models. Given that tau lesions correlate better with the degree of dementia than do amyloid-β (Aβ) plaques, their clearance may be clinically more efficacious than removing Aβ when cognitive deficits become evident in AD. Several complementary mechanisms of antibody-mediated removal of tau aggregates are likely to act in concert and the importance of each one may depend on antibody properties, the disease, and its stage. Clinical trials of tau immunotherapy are already underway and several more are likely to be initiated in the near future.
['Pedersen|Jan Torleif|JT|', 'Sigurdsson|Einar M|EM|']
D000544:Alzheimer Disease D000595:Amino Acid Sequence D000818:Animals D000906:Antibodies D006801:Humans D007167:Immunotherapy D008969:Molecular Sequence Data D024801:Tauopathies D016875:tau Proteins
immunotherapy Alzheimer's disease tau protein tauopathies