Chitosan hydrogel in combination with marine peptides from tilapia for burns healing.
The purpose of this study was to develop a promising burns dressing. Chiosan (CS) has been widely used as biomaterials, in combination with marine peptides (MPs) extracted from seawater cultured Tilapia, the newly developed material Chitosan-Marine Peptides hydrogels (CSMP) in this study showed antibacterial activity, pro-cell proliferation and migration, well burning healing. Pathological examinations by HE staining demonstrated that CSMP had pronounced wound healing efficiencies. In burn wounds treated with CSMP, reepithelialization and collagen fiber deposition were observed on day 7, the epithelium was completely regenerated by day 14, and the wounds were completely healed by day 21. Furthermore, CSMP can up-regulate the expression of FGF2 and VEGF. Collectively, these results suggest that CSMP may enhance cell migration and promote the skin regeneration, which demonstrates the potential application of CSMP in burning healing.
['Ouyang|Qian-Qian|QQ|', 'Hu|Zhang|Z|', 'Lin|Zhen-Peng|ZP|', 'Quan|Wei-Yan|WY|', 'Deng|Yi-Feng|YF|', 'Li|Si-Dong|SD|', 'Li|Pu-Wang|PW|', 'Chen|Yu|Y|']
D000818:Animals D000900:Anti-Bacterial Agents D002056:Burns D016923:Cell Death D002460:Cell Line D002465:Cell Movement D049109:Cell Proliferation D002470:Cell Survival D048271:Chitosan D005260:Female D016222:Fibroblast Growth Factor 2 D020100:Hydrogels D008297:Male D051379:Mice D008826:Microbial Sensitivity Tests D010455:Peptides D011817:Rabbits D012867:Skin D017550:Spectroscopy, Fourier Transform Infrared D017210:Tilapia D042461:Vascular Endothelial Growth Factor A D014945:Wound Healing
Chitosan Marine peptides Burns healing