Experimental Evaluation of the Effects of Low-Dose Heparin on the Behavior and Morphofunctional Status of the Liver in Wistar Rats with Posttraumatic Stress Disorders.
Posttraumatic stress disorders were induced in Wistar rats by modeling predatory stress. Animals tested in elevated plus-maze demonstrated signs of high anxiety and difficulties in space orientation. Behavioral disorders were paralleled by degenerative changes in hepatocytes. A course of low-dose high-molecular heparin after stress exposure promoted effective adaptation and normalization of behavioral and morphofunctional disorders. Analysis of the results indicated good prospects of heparin as an effective drug under conditions of exposure to extreme factors of psychotraumatic type.
['Kondashevskaya|M V|MV|']
D000818:Animals D014151:Anti-Anxiety Agents D004195:Disease Models, Animal D005106:Exploratory Behavior D006493:Heparin D022781:Hepatocytes D008099:Liver D008264:Macrophages D008297:Male D018782:Maze Learning D051381:Rats D017208:Rats, Wistar D013313:Stress Disorders, Post-Traumatic D013315:Stress, Psychological
liver posttraumatic stress disorders elevated plus-maze psychoemotional manifestations