Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta-analysis.
BACKGROUND
The relationship between phospholipase C ε-1 (PLCE1) rs2274223 variant and digestive tract cancer remains inconclusive despite extensive investigations. Therefore, we performed this meta-analysis to obtain a more credible conclusion.


METHODS
PubMed, Medline, and Embase were systematic searched. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.


RESULTS
A total of 27 studies were finally included. Pooled analyses suggested that PLCE1 rs2274223 variant was significantly correlated with the likelihood of esophageal cancer (dominant model: p < 0.001, OR = 0.77, 95% CI 0.72-0.83; recessive model: p < 0.001, OR = 1.28, 95% CI 1.12-1.45; additive model: p < 0.001, OR = 1.20, 95% CI 1.11-1.29; allele model: p < 0.001, OR = 0.80, 95% CI 0.74-0.88) and gastric cancer (recessive model: p = 0.001, OR = 1.27, 95% CI 1.10-1.47; allele model: p = 0.03, OR = 0.88, 95% CI 0.78-0.98) in overall population. Further subgroup analyses showed that the positive results were mainly driven by the East Asians. However, no positive results were detected in Caucasians and West Asians.


CONCLUSION
Our findings indicated that the PLCE1 rs2274223 variant might serve as a promising genetic biomarker of esophageal and gastric cancer in East Asians.
['Chen|Qingfa|Q|', 'Wang|Yu|Y|', 'Xu|Yan|Y|', 'Lin|Hai|H|', 'Xue|Fangxi|F|', 'Chen|Xingtian|X|0000-0002-2468-959X']
D044466:Asians D005770:Gastrointestinal Neoplasms D006801:Humans D054801:Phosphoinositide Phospholipase C D020641:Polymorphism, Single Nucleotide
Digestive tract cancer Meta-analysis Phospholipase C ε-1 (PLCE1) Genetic variant