Radiomics signature of computed tomography imaging for prediction of survival and chemotherapeutic benefits in gastric cancer.
To develop and validate a radiomics signature for the prediction of gastric cancer (GC) survival and chemotherapeutic benefits. In this multicenter retrospective analysis, we analyzed the radiomics features of portal venous-phase computed tomography in 1591 consecutive patients. A radiomics signature was generated by using the Lasso-Cox regression model in 228 patients and validated in internal and external validation cohorts. Radiomics nomograms integrating the radiomics signature were constructed, demonstrating the incremental value of the radiomics signature to the traditional staging system for individualized survival estimation. The performance of the nomograms was assessed with respect to calibration, discrimination, and clinical usefulness. The radiomics signature consisted of 19 selected features and was significantly associated with DFS (disease-free survival) and OS (overall survival). Multivariate analysis demonstrated that the radiomics signature was an independent prognostic factor. Incorporating the radiomics signature into the radiomics-based nomograms resulted in better performance for the estimation of DFS and OS than the clinicopathological nomograms and TNM staging system, with improved accuracy of the classification of survival outcomes. Further analysis showed that stage II and III patients with higher radiomics scores exhibited a favorable response to chemotherapy. In conclusion, the newly developed radiomics signature is a powerful predictor of DFS and OS, and it may predict which patients with stage II and III GC benefit from chemotherapy.
['Jiang|Yuming|Y|', 'Chen|Chuanli|C|', 'Xie|Jingjing|J|', 'Wang|Wei|W|', 'Zha|Xuefan|X|', 'Lv|Wenbing|W|', 'Chen|Hao|H|', 'Hu|Yanfeng|Y|', 'Li|Tuanjie|T|', 'Yu|Jiang|J|', 'Zhou|Zhiwei|Z|', 'Xu|Yikai|Y|', 'Li|Guoxin|G|']
D000328:Adult D000368:Aged D000971:Antineoplastic Combined Chemotherapy Protocols D015415:Biomarkers D015897:Comorbidity D005260:Female D006801:Humans D007091:Image Processing, Computer-Assisted D008297:Male D008875:Middle Aged D060787:Neoplasm Grading D009367:Neoplasm Staging D011379:Prognosis D012372:ROC Curve D015203:Reproducibility of Results D013274:Stomach Neoplasms D014057:Tomography, X-Ray Computed D016896:Treatment Outcome
Radiomics signature Gastric cancer Chemotherapy Prognosis