Novel understanding of self-reactive T cells.
In a recent issue of Immunity, Mark Davis and colleagues describe that thymic selection does not eliminate but prunes self-reactive T cell clones. Self-reactive T cells are a natural part of the T-cell repertoire and may be important in the fight against pathogens in addition to being important immune regulators.
['Andersen|Mads Hald|MH|']
self-reactive T cells thymic selection Anti-Tregs CD8 IDO PD-L1