Host-Range Shift Between Emerging P[8]-4 Rotavirus and Common P[8] and P[4] Strains.
In Tunisia, we observed that rotavirus P[8]-3 and P[4] strains in young children with gastroenteritis associate with secretor histo-blood group phenotype. In contrast, the emerging P[8]-4 strain, representing 10% of cases, was exclusively found in nonsecretor patients. Unlike VP8* from P[8]-3 and P[4] strains, the P[8]-4 VP8* protein attached to glycans from saliva samples regardless of the donor's secretor status. Interestingly, a high frequency of FUT2 enzyme deficiency (nonsecretor phenotype) was observed in the population. This may allow cocirculation of P[8]-3 and P[8]-4 strains in secretor and nonsecretor children, respectively.
['Khachou|Amira|A|', 'Le Moullac-Vaidye|Béatrice|B|', 'Peltier|Cécile|C|', 'Breiman|Adrien|A|', 'Imbert-Marcille|Berthe-Marie|BM|', 'Ruvoen-Clouet|Nathalie|N|', 'Aouni|Mahjoub|M|', 'Mastouri|Maha|M|', 'Chouchane|Slaheddine|S|', 'Le Pendu|Jacques|J|']
D002675:Child, Preschool D005647:Fucosyltransferases D005838:Genotype D058507:Host Specificity D006801:Humans D007223:Infant D007231:Infant, Newborn D010641:Phenotype D011134:Polysaccharides D016601:RNA-Binding Proteins D012401:Rotavirus D012400:Rotavirus Infections D012463:Saliva D017361:Viral Nonstructural Proteins D053585:Virus Attachment
rotavirus FUT2 fucosyltransferase genetic susceptibility histo-blood group antigen host range secretor/nonsecretor phenotypes