Programmed death-1 expression in cutaneous B-cell lymphoma.
BACKGROUND
Numbers of programmed death-1 (PD-1) positive T cells have prognostic significance in some types of nodal B-cell lymphomas, but data on PD-1 expression in cutaneous B-cell lymphoma (CBCL) are few. In this study we determined the expression and distribution of PD-1 on neoplastic B cells and reactive T cells in skin sections from primary CBCLs.


METHODS
By means of immunohistochemical staining, PD-1 expression was investigated in skin biopsies from 10 patients with primary cutaneous marginal zone lymphoma (PCMZL), 18 patients with primary cutaneous follicle center lymphoma (PCFCL) and 12 patients with primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT).


RESULTS
Neoplastic B cells were negative for PD-1 in all cases, except for two cases of PCDLBCL-LT. The frequency of PD-1(+) T cells was significantly higher in PCFCL than in PCMZL and PCDLBCL-LT, accounting for 20, 10 and 3% of the total number of infiltrating cells, and 60, 20 and 15% of the total number of CD3(+) T cells, respectively.


CONCLUSIONS
PD-1 is rarely expressed by the neoplastic B cells in CBCL. High percentages of PD-1(+) T cells, particularly if found outside germinal centers, support a diagnosis of PCFCL.
['Çetinözman|Fatma|F|', 'Koens|Lianne|L|', 'Jansen|Patty M|PM|', 'Willemze|Rein|R|']
D000328:Adult D000368:Aged D000369:Aged, 80 and over D001402:B-Lymphocytes D005260:Female D006801:Humans D016393:Lymphoma, B-Cell D008224:Lymphoma, Follicular D008297:Male D008875:Middle Aged D011379:Prognosis D061026:Programmed Cell Death 1 Receptor D012878:Skin Neoplasms D013601:T-Lymphocytes D055815:Young Adult
cutaneous B-cell lymphoma PD-1 follicular helper T cell non-Hodgkin lymphoma