Anti-aging effects of co-enzyme Q10 on periodontal tissues.
Oxidative stress is associated with age-related reactions. The anti-oxidative effects of a reduced form of co-enzyme Q10 (rCoQ10) suppress oxidative stress, which may contribute to the prevention of age-related inflammatory reactions. We examined the effects of topically applied rCoQ10 on periodontal inflammatory reactions in a rat aging model. Male Fischer 344 rats, 2 (n = 6) and 4 mos (n = 18) of age, were used. All of the two-month-old rats and 6 of the four-month-old rats were sacrificed and 12 remaining four-month-old rats received topically applied ointment with or without 1% rCoQ10 on the gingival surface until they reached 6 mos of age. The rats showed an age-dependent increase in circulating oxidative stress. RCoQ10 decreased oxidative DNA damage and tartrate-resistant acid-phosphatase-positive osteoclasts in the periodontal tissue at 6 mos of age as compared with the control. The same conditions lowered gene expression of caspase-1 and interleukin-1β in the periodontal tissue. Furthermore, Nod-like receptor protein 3 inflammasomes were less activated in periodontal tissues from rCoQ10-treated rats as compared with the control rats. Our results suggest that rCoQ10 suppresses age-related inflammatory reactions and osteoclast differentiation by inhibiting oxidative stress.
['Yoneda|T|T|', 'Tomofuji|T|T|', 'Ekuni|D|D|', 'Azuma|T|T|', 'Endo|Y|Y|', 'Kasuyama|K|K|', 'Machida|T|T|', 'Morita|M|M|']
D000080242:8-Hydroxy-2'-Deoxyguanosine D000135:Acid Phosphatase D000199:Actins D000367:Age Factors D000375:Aging D000539:Alveolar Process D000818:Animals D000975:Antioxidants D051017:Apoptosis Regulatory Proteins D053468:CARD Signaling Adaptor Proteins D002352:Carrier Proteins D020170:Caspase 1 D003598:Cytoskeletal Proteins D004249:DNA Damage D003849:Deoxyguanosine D045222:Electron Transport Chain Complex Proteins D005881:Gingiva D058847:Inflammasomes D053583:Interleukin-1beta D007527:Isoenzymes D008297:Male D023421:Models, Animal D016328:NF-kappa B D000071199:NLR Family, Pyrin Domain-Containing 3 Protein D010010:Osteoclasts D018384:Oxidative Stress D010519:Periodontium D011897:Random Allocation D051381:Rats D011916:Rats, Inbred F344 D018160:Receptors, Cytoplasmic and Nuclear D000071681:Tartrate-Resistant Acid Phosphatase D014451:Ubiquinone D014815:Vitamins
oxidative stress aging inflammasomes coenzyme Q10 periodontium preclinical drug evaluation