Healthy Lifestyle During Early Pregnancy and Risk of Gestational Diabetes Mellitus.
Previous studies have found associations between individual healthy behaviors and reduced risk of gestational diabetes mellitus (GDM); however, the association of composite healthy lifestyle during pregnancy with GDM has not been examined. Participants in the Omega Study (n = 3,005), a pregnancy cohort study conducted in Washington State (1996-2008), reported information on diet, physical activity, smoking, and stress during early pregnancy. Lifestyle components were dichotomized into healthy/unhealthy and then combined into a total lifestyle score (range, 0-4). Regression models were used to determine relative risk of GDM (n = 140 cases) in relation to healthy lifestyle. Twenty percent of participants had a healthy diet, 66% were physically active, 95% were nonsmokers, and 55% had low stress. Each 1-point increase in lifestyle score was associated with a 21% lower risk of GDM (95% confidence interval: 0.65, 0.96) after adjustment for age, race, and nulliparity. Adjustment for prepregnancy body mass index, prepregnancy physical activity, and prepregnancy smoking attenuated the associations slightly. Associations were similar in normal-weight and overweight/obese women. In this study, a composite measure of healthy lifestyle during early pregnancy was associated with substantially lower GDM risk. Public health messaging and interventions promoting multiple aspects of a healthy lifestyle during early pregnancy should be considered for GDM prevention.
['Badon|Sylvia E|SE|', 'Enquobahrie|Daniel A|DA|', 'Wartko|Paige D|PD|', 'Miller|Raymond S|RS|', 'Qiu|Chunfang|C|', 'Gelaye|Bizu|B|', 'Sorensen|Tanya K|TK|', 'Williams|Michelle A|MA|']
D000328:Adult D016640:Diabetes, Gestational D004032:Diet D015444:Exercise D005260:Female D015438:Health Behavior D006801:Humans D008019:Life Style D009765:Obesity D050177:Overweight D011247:Pregnancy D012307:Risk Factors D012907:Smoking D014861:Washington
lifestyle pregnancy gestational diabetes diabetes mellitus diet physical activity smoking life stress