Is Decreased Mean Platelet Volume in Allergic Airway Diseases Associated With Extent of the Inflammation Area?
OBJECTIVE
The aim of this study was to determine the relationship between mean platelet volume (MPV) level and the extent of airway inflammation in allergic airway diseases and in subgroups by comparison of inflammatory markers.


MATERIALS AND METHODS
A retrospective examination was made of 250 patients with allergic airway disease in the symptomatic phase, who had been newly diagnosed or who had abandoned treatment for at least 6 months. These patients were separated into 3 groups of asthma without allergic rhinitis (A - AR, n = 107), asthma with allergic rhinitis (A + AR, n = 83) and allergic rhinitis without asthma (AR - A, n = 60).


RESULTS
The MPV values of the study groups were found to be significantly lower than those of the control group (P < 0.001). MPV was determined to be negatively correlated with white blood cells, neutrophil count, platelet count and immunoglobulin E level in the study groups. The lowest MPV value was determined in the A + AR group (8.035 ± 1.05fL), which had the most extensive airway involvement, and the highest MPV value was determined in the AR - A group (8.109 ± 1.11fL) with the least airway involvement. MPV level sensitivity and the specificity of the best cutoff level were 74.5% and 40.8%, respectively. The cutoff level of 8.18fL for MPV level was found to have moderate sensitivity and low specificity for predicting pulmonary embolism.


CONCLUSIONS
The results of this study showed that MPV is lower in allergic airway diseases and a negative correlation was determined between MPV and inflammation markers but no statistically significant difference was determined between MPV and extent of the inflammation area.
['Akgedik|Recep|R|', 'Yağız|Yasin|Y|']
D000328:Adult D001249:Asthma D015415:Biomarkers D005260:Female D006801:Humans D007249:Inflammation D008297:Male D063847:Mean Platelet Volume D008875:Middle Aged D010976:Platelet Count D012189:Retrospective Studies D065631:Rhinitis, Allergic
Mean platelet volume Platelet Inflammation Asthma Allergic rhinitis