Multifunctional Magnetic Nanoplatform Eliminates Cancer Stem Cells via Inhibiting the Secretion of Extracellular Heat Shock Protein 90.
Cancer stem cells (CSCs) are responsible for malignant tumor initiation, recurrences, and metastasis. Therefore, targeting CSCs is a promising strategy for the development of cancer therapies. A big challenge for CSC-based cancer therapy is the overexpression of therapeutic stress protein, heat shock protein 90 (Hsp90), which protects CSCs from further therapeutic-induced damage, leading to the failure of treatment. Thus, efficient strategies to target CSCs are urgently needed for cancer therapy. To this end, a multifunctional nanoparticle (MNP) for CSC-based combined thermotherapy and chemotherapy is reported. This strategy dramatically suppresses tumor growth in breast CSC xenograft-bearing mice. Furthermore, a new mechanism is present that the MNP exerts its striking effects on CSCs by inhibiting the secretion of extracellular Hsp90 (eHsp90), resulting in the interruption of several key signaling pathways. These findings open new perspectives on the use of an MNP for effective CSC-based cancer treatment by inhibiting the function of eHsp90.
['Liu|Yajing|Y|', 'Suo|Xiaomin|X|', 'Peng|Haotong|H|', 'Yan|Weixiao|W|', 'Li|Hongjuan|H|', 'Yang|Xinjian|X|', 'Li|Zhenhua|Z|', 'Zhang|Jinchao|J|0000-0002-5279-0468', 'Liu|Dandan|D|']
D000818:Animals D000906:Antibodies D017209:Apoptosis D016227:Benzoquinones D045744:Cell Line, Tumor D052203:Ferrosoferric Oxide D018841:HSP90 Heat-Shock Proteins D006801:Humans D018960:Hyaluronan Receptors D006979:Hyperthermia, Induced D047029:Lactams, Macrocyclic D058185:Magnetite Nanoparticles D051379:Mice D009369:Neoplasms D014411:Neoplastic Stem Cells D016062:Porosity D015398:Signal Transduction D012822:Silicon Dioxide D014183:Transplantation, Heterologous
cancer stem cells extracellular heat shock protein 90 multifunctional nanoparticles thermotherapy and chemotherapy signaling pathways