Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse.
The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-γ coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upregulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.
['Piccinin|Elena|E|0000-0002-6514-2689', 'Arconzo|Maria|M|', 'Graziano|Giusi|G|', 'Vacca|Michele|M|0000-0002-1973-224X', 'Peres|Claudia|C|', 'Bellafante|Elena|E|', 'Villani|Gaetano|G|', 'Moschetta|Antonio|A|0000-0003-2123-6074']
D000818:Animals D005260:Female D008099:Liver D008107:Liver Diseases D051379:Mice D035683:MicroRNAs D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha D060888:Real-Time Polymerase Chain Reaction
microRNA liver metabolism coactivators PGC-1 liver diseases