Prognostic performance of pre-treatment NLR and PLR in patients suffering from osteosarcoma.
BACKGROUND
Inflammatory response markers have been proposed to predict the clinical outcomes in various cancers. The aim of this study was to explore the influence of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) on the prognosis of osteosarcoma.


METHODS
Three hundred fifty-nine patients who underwent curative surgery for osteosarcoma were enrolled from 2005 to 2010. NLR and PLR were calculated from peripheral blood cell counts taken at pre-treatment. Optimal cutoff values of NLR and PLR were determined on the basis of receiver operating characteristic curve analysis. A predictive model was established to predict the clinical outcome for overall survival, and the predictive accuracy of this model was determined by concordance index (c-index).


RESULTS
Our results showed that advanced stage and metastasis at diagnosis were significantly associated with the high NLR and PLR groups. NLR was an independent prognostic indicator for overall survival (HR = 1.80, 95% CI = 1.35-2.41, P < 0.001) and progression-free survival (HR = 1.65, 95% CI = 1.26-2.15, P < 0.001), except for PLR. The nomogram could perform well in the prediction of overall survival in patients with osteosarcoma (c-index 0.829).


CONCLUSIONS
Our results suggest that both NLR and PLR can reflect clinical prognosis. NLR is more predictive of overall survival and progression-free survival than PLR.
['Xia|Wen-Kai|WK|', 'Liu|Zhi-Li|ZL|', 'Shen|Dong|D|', 'Lin|Qing-Feng|QF|', 'Su|Jun|J|', 'Mao|Wei-Dong|WD|']
D000230:Adenocarcinoma D000328:Adult D000368:Aged D014408:Biomarkers, Tumor D001792:Blood Platelets D001859:Bone Neoplasms D005260:Female D005500:Follow-Up Studies D006801:Humans D008207:Lymphatic Metastasis D008214:Lymphocytes D008297:Male D008875:Middle Aged D009367:Neoplasm Staging D009504:Neutrophils D012516:Osteosarcoma D011300:Preoperative Care D011379:Prognosis D012189:Retrospective Studies D015996:Survival Rate D055815:Young Adult
NLR PLR Osteosarcoma Prognosis