Development of a novel hybrid strategy for transcatheter pulmonary valve placement in patients following transannular patch repair of tetralogy of fallot.
BACKGROUND
Transcatheter pulmonary valve replacement (tPVR) is an accepted therapy for treatment of dysfunctional right ventricular outflow tract (RVOT) conduits. At present, the majority of Fallot patients who undergo transannular patch (TAP) repair are not candidates for tPVR due to the large irregular nature of their RVOT. Herein, we describe a novel approach to assessing the RVOT in this group, which may then be used to design, test, and carry out hybrid RVOT modification and transcatheter valve implantation in this population.


METHODS
A retrospective analysis of TAP patients who underwent 3D modeling of the RVOT which was then used to develop individualized hybrid procedures designed to modify the RVOT, thereby rendering patients suitable for transcatheter valve implantation.


RESULTS
Eight consecutive patients underwent 3D RVOT modeling followed by hybrid implantation of a transcatheter valve via a perventricular approach. A landing zone stent was placed in all and four required additional intravascular geometric remodeling of the RVOT prior to valve implant. Transcatheter valves were successfully implanted in all. There were no instances of valve malposition, embolization, or death. There was one minor procedural complication. No patient had more than trivial pulmonary regurgitation at follow-up.


CONCLUSIONS
Using a hybrid approach to remodel the RVOT in TAP patients supported by preprocedural 3D-model planning allows for successful tPVR implantation in this population. A larger cohort and longer follow-up will be needed to determine the ultimate utility of this approach.
['Phillips|Alistair B M|AB|', 'Nevin|Phillip|P|', 'Shah|Avni|A|', 'Olshove|Vincent|V|', 'Garg|Ruchira|R|', 'Zahn|Evan M|EM|']
D000293:Adolescent D000328:Adult D006328:Cardiac Catheterization D006348:Cardiac Surgical Procedures D002648:Child D006350:Heart Valve Prosthesis D019918:Heart Valve Prosthesis Implantation D006801:Humans D021621:Imaging, Three-Dimensional D008279:Magnetic Resonance Imaging D008875:Middle Aged D008953:Models, Anatomic D008955:Models, Cardiovascular D011474:Prosthesis Design D011664:Pulmonary Valve D011665:Pulmonary Valve Insufficiency D015641:Radiography, Interventional D012189:Retrospective Studies D015607:Stents D013771:Tetralogy of Fallot D014057:Tomography, X-Ray Computed D016896:Treatment Outcome D055815:Young Adult
pulmonary valve congenital tetralogy Fallot