De novo C3 glomerulonephritis in a renal allograft.
C3 glomerulonephritis (C3GN) is a recently described, rare glomerular disease characterized by predominant or sole glomerular C3 deposits. Morphologic features of C3GN are similar to those of dense deposit disease (DDD); however, ribbon-like intramembranous electron-dense deposits are absent in the former. We report a case of de novo C3GN in a renal allograft with morphologic transformation to DDD. A 6-year-old boy presented with congenital left renal agenesis and right ureteropelvic junction obstruction. The patient underwent pyeloplasty but experienced recurrent urinary tract infections. At the age of 22 years, he received a renal allograft from a living related donor. C3GN was diagnosed after 1 year of transplantation; initial histology showed minimal mesangiopathy and this progressed to mesangial proliferation and membranoproliferative features over the next 7 years. Serum creatinine levels were stabilized with anti-rejection treatments for combating repeated episodes of acute rejection; however, glomerular and tubular band-like electron-dense deposits became evident.
['Nahm|Ji Hae|JH|', 'Song|Seung Hwan|SH|', 'Kim|Yu Seun|YS|', 'Cheong|Hae-Il|HI|', 'Lim|Beom Jin|BJ|', 'Kim|Beom Seok|BS|', 'Jeong|Hyeon Joo|HJ|']
D064591:Allografts D001706:Biopsy D003176:Complement C3 D018450:Disease Progression D005455:Fluorescent Antibody Technique D015432:Glomerulonephritis, Membranoproliferative D006801:Humans D007166:Immunosuppressive Agents D007678:Kidney Glomerulus D016030:Kidney Transplantation D019520:Living Donors D008297:Male D008854:Microscopy, Electron D013997:Time Factors D016896:Treatment Outcome D055815:Young Adult
C3 glomerulonephritis dense deposit disease rejection kidney transplant