EFFICACY AND SAFETY OF A SINGLE-PILL COMBINATION OF ATORVASTATIN/AMLODIPINE IN PATIENTS WITH ARTERIAL HYPERTENSION AND DYSLIPIDEMIA.
- The aim was to evaluate the efficacy of a single-pill combination of atorvastatin/amlodipine in patients with arterial hypertension, dyslipidemia and moderate to high cardiovascular risk. This prospective study included 243 patients with arterial hypertension, dyslipidemia and moderate to high cardiovascular risk, mean age 63.3±9.8 years. All patients were prescribed a treatment with one of the following doses of a single-pill combination of atorvastatin/amlodipine: 10/5, 10/10, 20/5 or 20/10 mg daily. The follow-up period was 3 months. The mean baseline values of the systolic and diastolic blood pressure were 155.7±16.2 and 92.0±9.2 mm Hg, respectively. At month 3, the respective mean systolic and diastolic blood pressure values were 136.9±26.9 and 80.6±5.1 mm Hg. The mean baseline values of total cholesterol and low-density lipoprotein cholesterol were 6.6±1.2 and 4.4±1.1 mmol/L, respectively. At month 3, the respective mean values of total cholesterol and low-density lipoprotein cholesterol were 5.1±0.9 and 2.9±1.0 mmol/L. Treatment was discontinued in 9 (3.7%) patients due to adverse events. In conclusion, treatment with the single-pill combination of atorvastatin/amlodipine was effective and well tolerated by the patients with arterial hypertension, dyslipidemia and moderate to high cardiovascular risk.
['Naydenov Naydenov|Stefan|S|', 'Margaritov Runev|Nikolay|N|', 'Ivanov Manov|Emil|E|', 'Georgieva Torbova-Gigova|Svetla|S|']
D000368:Aged D017311:Amlodipine D000924:Anticholesteremic Agents D000959:Antihypertensive Agents D001794:Blood Pressure D002784:Cholesterol D008078:Cholesterol, LDL D004305:Dose-Response Relationship, Drug D004338:Drug Combinations D016903:Drug Monitoring D050171:Dyslipidemias D005260:Female D006538:Heptanoic Acids D006801:Humans D006973:Hypertension D008297:Male D008875:Middle Aged D011446:Prospective Studies D011758:Pyrroles D016896:Treatment Outcome
Hypertension Dyslipidemias Antihypertensive agents Cardiovascular diseases