Zika Virus Outbreak - Should assisted reproduction patients avoid pregnancy?
OBJECTIVE
To discuss the requirement from the National Health Surveillance Agency (ANVISA), for assisted reproduction treatment patients to undergo laboratory tests for ZIKV detection, and if the public health authorities and government leaders' recommendations to women simply avoid pregnancy is prudent.


METHODS
This study was performed in a university-affiliated in vitro fertilization center in Brazil. We present a critical discussion on the risk of microcephaly due to ZIKV infection and the prevalence of other harmful pathogens to vulnerable pregnant women and infants. We assessed, 954 patients undergoing intracytoplasmic sperm injection cycles (ICSI), between April and November of 2016, concerning the results of ZIKV test, according to different regions in Brazil.


RESULTS
Patients undergoing ICSI cycles were split into groups, according to their region of origin: 28 (3.0%) were from the North, 27 (2.8%) were from the Northeast, 40 (4.2%) were from the Midwest, 830 (87.2%) were from the Southeast, and 29 (3.0%) were from the South. Concerning the diagnosis, 112 samples had a positive or inconclusive result for ZIKV, by chromatography immunoassay. These samples were re-analyzed by ELISA and no result was positive. All positive results were from the Southeast region and none from the Northeast or Midwest regions, which are considered endemic regions.


CONCLUSION
ZIKV test before the onset of assisted reproduction treatments does not rule out the risk of the infection during pregnancy. In addition, although ZIKV infection risk is extremely high, the microcephaly risk due to ZIKV is not higher than the risk of miscarriage and birth defects due to other recognized pathogens.
['Borges|Edson|E|', 'Braga|Daniela Paes de Almeida Ferreira|DPAF|', 'Zanetti|Bianca Ferrarini|BF|', 'Setti|Amanda Souza|AS|', 'Provenza|Rodrigo Rosa|RR|', 'Iaconelli|Assumpto|A|']
D000022:Abortion, Spontaneous D001938:Brazil D000013:Congenital Abnormalities D004196:Disease Outbreaks D005260:Female D006801:Humans D008831:Microcephaly D011247:Pregnancy D020554:Sperm Injections, Intracytoplasmic D000071244:Zika Virus D000071243:Zika Virus Infection
Zika virus pregnancy microcephaly miscarriage birth defects