The objectives, design and implementation of the INTERGROWTH-21st Project.
INTERGROWTH-21(st) is a multicentre, multiethnic, population-based project, being conducted in eight geographical areas (Brazil, China, India, Italy, Kenya, Oman, UK and USA), with technical support from four global specialised units, to study growth, health and nutrition from early pregnancy to infancy. It aims to produce prescriptive growth standards, which conceptually extend the World Health Organization (WHO) Multicentre Growth Reference Study (MGRS) to cover fetal and newborn life. The new international standards will describe: (1) fetal growth assessed by clinical and ultrasound measures; (2) postnatal growth of term and preterm infants up to 2 years of age; and (3) the relationship between birthweight, length and head circumference, gestational age and perinatal outcomes. As the project has selected healthy cohorts with no obvious risk factors for intrauterine growth restriction, these standards will describe how all fetuses and newborns should grow, as opposed to traditional charts that describe how some have grown at a given place and time. These growth patterns will be related to morbidity and mortality to identify levels of perinatal risk. Additional aims include phenotypic characterisation of the preterm and impaired fetal growth syndromes and development of a prediction model, based on multiple ultrasound measurements, to estimate gestational age for use in pregnant women without access to early/frequent antenatal care.
['Villar|J|J|', 'Altman|D G|DG|', 'Purwar|M|M|', 'Noble|J A|JA|', 'Knight|H E|HE|', 'Ruyan|P|P|', 'Cheikh Ismail|L|L|', 'Barros|F C|FC|', 'Lambert|A|A|', 'Papageorghiou|A T|AT|', 'Carvalho|M|M|', 'Jaffer|Y A|YA|', 'Bertino|E|E|', 'Gravett|M G|MG|', 'Bhutta|Z A|ZA|', 'Kennedy|S H|SH|', '|||']
D001837:Body Weights and Measures D002657:Child Development D002985:Clinical Protocols D003430:Cross-Sectional Studies D005260:Female D047109:Fetal Development D005317:Fetal Growth Retardation D005865:Gestational Age D057238:Growth Charts D006801:Humans D007223:Infant D007230:Infant, Low Birth Weight D007231:Infant, Newborn D007234:Infant, Premature D008137:Longitudinal Studies D015337:Multicenter Studies as Topic D011247:Pregnancy D047928:Premature Birth D039401:Prenatal Nutritional Physiological Phenomena D011446:Prospective Studies D012107:Research Design D016216:Ultrasonography, Prenatal
INTERGROWTH-21st growth nutrition standards Fetal newborn preterm