Impact of preformed and de novo anti-HLA DP antibodies in renal allograft survival.
The influence of antibodies against HLA-DP antigens detected with solid-phase assays on graft survival after kidney transplantation (KT) is uncertain. We evaluated with Luminex® the prevalence of pre- and posttransplant DP antibodies in 440 KT patients and their impact on graft survival. For 291 patients with available pretransplant samples, DP antibodies were present in 39.7% KT with pretransplant HLA antibodies and 47.7% with DSA. Graft survival of KT with pretransplant class-II DSA was worse than with non-DSA (p=0.01). DP antibodies did not influence graft survival. Of 346 patients monitored post-KT, 17.1% had HLA class-II antibodies, 56% with DP antibodies. Class-II DSA was detected in 39%, 60.9% of them had DP antibodies. Graft survival was worse in patients with class-II DSA (p=0.022). DP antibodies did not change these results. The presence of isolated DP antibodies was a rare event both pre- and posttransplantation (1.03 and 0.86%). The presence of pretransplant and posttransplant DSA is associated with a negative impact on graft survival. However, the presence of DP antibodies does not modify this impact significantly.
['Redondo-Pachón|Dolores|D|', 'Pascual|Julio|J|', 'Pérez-Sáez|María J|MJ|', 'García|Carmen|C|', 'Hernández|Juan José|JJ|', 'Gimeno|Javier|J|', 'Mir|Marisa|M|', 'Crespo|Marta|M|']
D000328:Adult D000368:Aged D064591:Allografts D005260:Female D006084:Graft Rejection D006085:Graft Survival D006682:HLA-DP Antigens D006650:Histocompatibility Testing D006801:Humans D007518:Isoantibodies D007668:Kidney D016030:Kidney Transplantation D008297:Male D008875:Middle Aged D014184:Transplantation, Homologous
Graft survival HLA-DP antibodies Renal transplant