Association between male pattern baldness and testicular germ cell tumor: a meta-analysis.
BACKGROUND
The relationship between male pattern baldness and incidence of testicular cancer remains inconclusive. Hence, we performed the present meta-analysis based on all eligible case-control studies.


METHODS
A comprehensive literature search was performed in July 30th 2018 based on PUBMED, EMBASE and Web of science database. Pooled odds ratio(OR) and its 95% confidence intervals (95% CIs) was calculated with a DerSimonian and Laird random-effects.


RESULTS
The pooled results were included in this meta-analysis. Overall, We have demonstrated statistically signification between baldness(any pattern) and testicular cancer was identified (OR: 0.61, 95% CI:0.50-0.74). There was no obvious heterogeneity across included studies (P = 0.22 for heterogeneity, I2 = 30%). When subgroup analysis by types of baldness, We found a statistically significant association was observed that baldness(I-VII) might become a protective factor for the risk of testicular germ cell tumor(TGCT). There was no definite connection between alopecia and the different types of TGCT.


CONCLUSION
Individuals with any pattern baldness may have a decreased risk of testicular cancer, all of analyses studies are warranted to confirm our preliminary findings. According to subgroup analysis of different hair loss grades, we found that 2 stage(II) hair loss can decrease more strongly testicular cancer risk than any other grades. Despite of our findings, We still need further researches to advance knowledge in this field.
['Zhou|Jiatong|J|', 'Xia|Shuai|S|', 'Li|Tao|T|', 'Liu|Ranlu|R|']
D000505:Alopecia D016022:Case-Control Studies D006801:Humans D008297:Male D009373:Neoplasms, Germ Cell and Embryonal D016017:Odds Ratio D017594:Publication Bias D012307:Risk Factors D013736:Testicular Neoplasms
Male pattern baldness Testicular germ cell tumor Meta-analysis Risk