Malignant acrospiroma: a case report in the era of next generation sequencing.
BACKGROUND
Malignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. Typically, it presents as large ulcerated nodules, and diagnosis can be challenging as it has great overlap with its benign counterpart.


CASE PRESENTATION
We herein report a case of acral malignant acrospiroma, initially treated with surgical excision and adjuvant radiotherapy. After metastatic disease was confirmed, subject received multiple lines of chemo- as well as targeted therapy. Genomic testing was also done using next generation sequencing.


CONCLUSION
To the best of our knowledge, this is the first case of acral malignant acrospiroma with reported next generation sequencing results.
['Diab|Maria|M|0000-0002-4809-9535', 'Gabali|Ali|A|', 'Kittaneh|Muaiad|M|']
D018250:Acrospiroma D000368:Aged D015894:Genome, Human D059014:High-Throughput Nucleotide Sequencing D006801:Humans D008297:Male D009362:Neoplasm Metastasis D013544:Sweat Gland Neoplasms
Malignant Acrospiroma Case report Next generation Acral