N-terminal prohormone B-type natriuretic peptide and weaning outcome in postoperative patients with pulmonary complications.
OBJECTIVE
To evaluate the relationship between plasma N-terminal prohormone B-type natriuretic peptide (NT-proBNP) and weaning outcomes, and the ability of NT-proBNP level to predict weaning success, in cancer patients with pulmonary complications undergoing noncardiac major surgeries.


METHODS
Patients who were mechanically ventilated following postoperative respiratory failure were enrolled. NT-proBNP levels at the end of a 2-h spontaneous breathing trial were measured. Weaning was considered a success in patients who completed the trial and maintained spontaneous breathing following extubation for >48 h.


RESULTS
Out of 29 patients, 22 patients weaned successfully but weaning failed in 7 patients. Plasma NT-proBNP was significantly higher in the weaning failure group than in the weaning success group. For predicting weaning success, the optimal NT-proBNP threshold value at the end of the spontaneous breathing trial was <448 ng/l (receiver operating characteristic analysis; sensitivity 68.18%, specificity 85.71%, positive predictive value 93.7% and negative predictive value 46.2%).


CONCLUSION
Measuring NT-proBNP at the end of a spontaneous breathing trial may assist in predicting weaning success, as a noninvasive, quantitative and repeatable indicator of cardiac stress in patients with postsurgical respiratory failure.
['Ma|Gang|G|', 'Liao|Wei|W|', 'Qiu|Junke|J|', 'Su|Quanguan|Q|', 'Fang|Yi|Y|', 'Gu|Baochun|B|']
D000368:Aged D060666:Airway Extubation D015415:Biomarkers D005260:Female D006801:Humans D008168:Lung D008297:Male D008875:Middle Aged D020097:Natriuretic Peptide, Brain D009369:Neoplasms D010446:Peptide Fragments D011183:Postoperative Complications D012372:ROC Curve D012121:Respiration, Artificial D012131:Respiratory Insufficiency D016896:Treatment Outcome D015300:Ventilator Weaning D012122:Ventilators, Mechanical
weaning postoperative N-terminal prohormone B-type natriuretic peptide (NT-proBNP) mechanical ventilation respiratory failure