Association of GWAS-supported noncoding area loci rs404860, rs3117098, and rs7775228 with asthma in Chinese Zhuang population.
BACKGROUND
Asthma is a complicated and polygenic inheritance disease, and its prevalence increases worldwide. Recent genome-wide association studies (GWASs) identified a significant association of single nucleotide polymorphism with asthma in the Japanese population. This study aimed to examine the association of GWAS-supported noncoding area loci, namely rs404860, rs3117098, and rs7775228, with asthma in Chinese Zhuang population.


METHODS
A case-control study involving 223 individuals, comprising 123 patients with asthma and 100 healthy controls, was conducted. Genotypes were determined by polymerase chain reaction (PCR)/ligase detection reaction assay. The association between gene polymorphisms and asthma risk was calculated by logistic regression analysis using different genetic models through comparisons of alleles (A vs a), homozygote genotypes (AA vs aa), heterozygote genotypes (Aa vs aa), dominant models (AA+Aa vs aa), and recessive models (AA vs. Aa+aa).


RESULTS
The distribution of the genotype frequency of rs3117098 was statistically different between the case and control groups. For rs3117098, significant associations were observed through comparisons of alleles (OR: 1.832, 95% CI: 1.048-3.204, P = .034) and dominant models (OR: 2.065, 95% CI: 1.001-4.260, P = .050). The statistical analysis showed no significant difference for loci rs404860 and rs7775228 between patients with asthma and controls.


CONCLUSION
rs3117098 may be the risk factor for asthma in Chinese Zhuang population.
['Liang|Si-Qiao|SQ|', 'Deng|Jing-Min|JM|https://orcid.org/0000-0003-0189-5371', 'Wei|Xuan|X|', 'Chen|Zhang-Rong|ZR|', 'Yang|Mei-Ling|ML|', 'Qin|Hua-Jiao|HJ|', 'Zhang|Jian-Quan|JQ|', 'He|Zhi-Yi|ZY|']
D000328:Adult D000483:Alleles D044466:Asians D001249:Asthma D000071797:Butyrophilins D016022:Case-Control Studies D002681:China D005260:Female D005787:Gene Frequency D020022:Genetic Predisposition to Disease D055106:Genome-Wide Association Study D006683:HLA-DQ Antigens D006801:Humans D008297:Male D020641:Polymorphism, Single Nucleotide D000074562:Receptor, Notch4
GWAS-supported noncoding area loci asthma Zhuang population