Influence of clamping parameters on the trauma of rabbit small intestine tissue.
BACKGROUND
During clamping operation for minimally invasive intestinal surgery, patients often suffer from small intestine trauma. This phenomenon will lead to various complications, increase recovery time and cause pain for patients.


METHODS
In this paper, preliminary simulations of small intestine clamping operations in the minimally invasive surgery were made by conducting compression tests under different clamping stresses, durations and loading rates. A pathological grading system was designed after microscope observation to quantitatively evaluate the trauma of small intestine tissue.


FINDINGS
Results showed that different traumas: inflammatory cell infiltration, hyperemia, hemorrhage and rupture between serosa and muscularis, as well as villi destruction could be observed on the clamping sites of the small intestine tissue. When the clamping parameters (clamping stress, duration and loading rate) increased, the degree of the tissue trauma increased. There existed safe thresholds for clamping operations, at which severe trauma of small intestine tissues could be avoided in the clamping process.


INTERPRETATION
As the clamping parameters increased, the strain, that is the deformation of the small intestine tissue increased. The increase in the deformation would induce the aggravation of trauma degree.
['Wang|Jin|J|', 'Li|Wei|W|', 'Wang|Bingrui|B|', 'Zhou|Zhongrong|Z|']
D000818:Animals D003250:Constriction D007249:Inflammation D007421:Intestine, Small D010535:Laparoscopy D008297:Male D019060:Minimally Invasive Surgical Procedures D011817:Rabbits D013314:Stress, Mechanical D013525:Surgical Instruments D014947:Wounds and Injuries
Trauma Rabbit small intestine Compression Laparoscopic grasper Pathological assessment