Prognostic value of pre- and post-treatment health-related quality of life in predicting survival of patients with brain metastases.
AIM
The present study aimed to determine the prognostic survival value of pretreatment health-related quality of life (HRQOL) and changes in HRQOL following whole-brain radiation treatment in patients with brain metastases.


METHODS
Patients who were treated with whole-brain radiation treatment and completed HRQOL questionnaires were included. Univariate and multivariate Cox proportional hazard models of overall survival (OS) were conducted for overall HRQOL and domain scores.


RESULTS & CONCLUSION
Patients with lower HRQOL at baseline, especially lower physical functioning and motor dysfunction domains, were more likely to have poorer survival. Changes in overall HRQOL and its domains were not significantly related to OS. Pretreatment HRQOL, especially physical functioning and motor dysfunction, has added prognostic value in patients with brain metastases.
['Wong|Erin|E|', 'Rowbottom|Leigha|L|', 'Tsao|May|M|', 'Zhang|Liying|L|', 'McDonald|Rachel|R|', 'Danjoux|Cyril|C|', 'Barnes|Elizabeth|E|', 'Chan|Stephanie|S|', 'Chow|Edward|E|']
D000368:Aged D000369:Aged, 80 and over D001932:Brain Neoplasms D005260:Female D005500:Follow-Up Studies D006257:Head D006801:Humans D053208:Kaplan-Meier Estimate D008297:Male D008875:Middle Aged D011379:Prognosis D011788:Quality of Life D011878:Radiotherapy D011795:Surveys and Questionnaires D016896:Treatment Outcome
quality of life brain metastases overall survival prognosis