Optimization of mass spectrometry acquisition parameters for determination of polycarbonate additives, degradation products, and colorants migrating from food contact materials to chocolate.
The interest towards "substances of emerging concerns" referred to objects intended to come into contact with food is recently growing. Such substances can be found in traces in simulants and in food products put in contact with plastic materials. In this context, it is important to set up analytical systems characterized by high sensitivity and to improve detection parameters to enhance signals. This work was aimed at optimizing a method based on UHPLC coupled to high resolution mass spectrometry to quantify the most common plastic additives, and able to detect the presence of polymers degradation products and coloring agents migrating from plastic re-usable containers. The optimization of mass spectrometric parameter settings for quantitative analysis of additives has been achieved by a chemometric approach, using a full factorial and d-optimal experimental designs, allowing to evaluate possible interactions between the investigated parameters. Results showed that the optimized method was characterized by improved features in terms of sensitivity respect to existing methods and was successfully applied to the analysis of a complex model food system such as chocolate put in contact with 14 polycarbonate tableware samples. A new procedure for sample pre-treatment was carried out and validated, showing high reliability. Results reported, for the first time, the presence of several molecules migrating to chocolate, in particular belonging to plastic additives, such Cyasorb UV5411, Tinuvin 234, Uvitex OB, and oligomers, whose amount was found to be correlated to age and degree of damage of the containers.
['Bignardi|Chiara|C|', 'Cavazza|Antonella|A|http://orcid.org/0000-0002-2885-4839', 'Laganà|Carmen|C|', 'Salvadeo|Paola|P|', 'Corradini|Claudio|C|']
D002138:Calibration D000069956:Chocolate D002851:Chromatography, High Pressure Liquid D005506:Food Contamination D018857:Food Packaging D006794:Household Articles D006801:Humans D057230:Limit of Detection D010969:Plastics D011091:Polyesters D015203:Reproducibility of Results D053719:Tandem Mass Spectrometry
polycarbonate additives degradation products migration chocolate