Alpha-Synuclein RNA Expression is Increased in Major Depression.
Alpha-synuclein (SNCA) is a small membrane protein that plays an important role in neuro-psychiatric diseases. It is best known for its abnormal subcellular aggregation in Lewy bodies that serves as a hallmark of Parkinson's disease (PD). Due to the high comorbidity of PD with depression, we investigated the role of SNCA in patients suffering from major depressive disorder (MDD). SNCA mRNA expression levels were analyzed in peripheral blood cells of MDD patients and a healthy control group. SNCA mRNA expression was positively correlated with severity of depression as indicated by psychometric assessment. We found a significant increase in SNCA mRNA expression levels in severely depressed patients compared with controls. Thus, SNCA analysis could be a helpful target in the search for biomarkers of MDD.
['Rotter|Andrea|A|', 'Lenz|Bernd|B|0000-0001-6086-0924', 'Pitsch|Ruben|R|', 'Richter-Schmidinger|Tanja|T|0000-0001-5426-8342', 'Kornhuber|Johannes|J|0000-0002-8096-3987', 'Rhein|Cosima|C|']
D000328:Adult D003865:Depressive Disorder, Major D005260:Female D005786:Gene Expression Regulation D006801:Humans D008297:Male D008875:Middle Aged D011594:Psychometrics D012333:RNA, Messenger D051844:alpha-Synuclein
alpha-synuclein major depression SNCA Hamilton Scale of Depression