Increased red cell distribution width is associated with poor stem cell mobilization in patients with advanced chronic heart failure.
Parameters associated with poor CD34(+) stem cell mobilization in advanced chronic heart failure (CHF) patients were investigated. Forty-four CHF patients underwent bone marrow stimulation with granulocyte colony stimulating factor. Poor cell mobilization presents in 32% of patients. Poor and good mobilizers did not differ significantly regarding age, gender, left ventricular ejection fraction, kidney or liver function and exercise capacity. Significant differences were found regarding NT-proBNP levels and red cell distribution width (RDW). Increased RDW was the only independent predictor of poor CD34(+) stem cell mobilization on multivariable analysis and may serve as a biomarker of poor stem cell mobilization in CHF patients.
['Poglajen|Gregor|G|', 'Sever|Matjaž|M|', 'Černelč|Peter|P|', 'Haddad|Francois|F|', 'Vrtovec|Bojan|B|']
D000328:Adult D000368:Aged D018952:Antigens, CD34 D015415:Biomarkers D002908:Chronic Disease D004909:Erythrocyte Indices D005260:Female D016179:Granulocyte Colony-Stimulating Factor D006333:Heart Failure D019650:Hematopoietic Stem Cell Mobilization D018380:Hematopoietic Stem Cell Transplantation D006412:Hematopoietic Stem Cells D006801:Humans D008297:Male D008875:Middle Aged D015999:Multivariate Analysis D017063:Outcome Assessment, Health Care
heart failure Bone marrow stem cell therapy