Antioxidant properties of HDL.
High-density lipoprotein (HDL) provides a pathway for the passage of lipid peroxides and lysophospholipids to the liver via hepatic scavenger receptors. Perhaps more importantly, HDL actually metabolizes lipid hydroperoxides preventing their accumulation on low-density lipoprotein (LDL), thus impeding its atherogenic structural modification. A number of candidates have been suggested to be responsible for HDL's antioxidant function, with paraoxonase-1 (PON1) perhaps the most prominent. Here we review the evidence for HDL anti-oxidative function and the potential contributions of apolipoproteins, lipid transfer proteins, paraoxonases and other enzymes associated with HDL.
['Soran|Handrean|H|', 'Schofield|Jonathan D|JD|', 'Durrington|Paul N|PN|']
high-density lipoprotein apolipoprotein A1 glycated low-density lipoprotein oxidized low-density lipoprotein paraoxonase 1