Anxiety- and Depressive-Like Behaviors are Associated with Altered Hippocampal Energy and Inflammatory Status in a Mouse Model of Crohn's Disease.
Depression and anxiety are common comorbid disorders observed in patients with inflammatory bowel disease (IBD). Increasing line of evidence indicates that immune-inflammatory responses are involved in co-occurrence of mood disorders and IBD. However, the mechanisms through which immune-inflammatory pathways modulate this comorbidity are not yet understood. This study investigated the role of innate immunity in the development of behavioral abnormalities associated with an animal model of Crohn's disease (CD). To do this, we induced colitis in male adult mice by intrarectal (i.r.) injection of DNBS (Dinitrobenzene sulfonic acid). After 3 days, we performed behavioral tests for anxiety- and depressive-like behaviors as well as tissue collection. Our results showed that DNBS-induced colonic inflammatory responses were accompanied by infiltration of inflammatory cells, and increased expression of genes involved in toll-like receptor signaling pathway in intestinal tissue. Furthermore, the DNBS-treated mice showed depressive- and anxiety-like behaviors which were associated with increased expression of the inflammatory genes and abnormal mitochondrial function in the hippocampus. These results suggest that peripheral inflammation is able to increase the transcriptional level of the genes in toll-like receptor pathway, induces abnormal mitochondrial function in the hippocampus, and these negative effects may be involved in the co-occurrence of anxiety and depression in early stages of CD.
['Haj-Mirzaian|Arya|A|', 'Amiri|Shayan|S|', 'Amini-Khoei|Hossein|H|', 'Hosseini|Mir-Jamal|MJ|', 'Haj-Mirzaian|Arvin|A|', 'Momeny|Majid|M|', 'Rahimi-Balaei|Maryam|M|', 'Dehpour|Ahmad Reza|AR|']
D000818:Animals D001007:Anxiety D001522:Behavior, Animal D001557:Benzenesulfonates D003092:Colitis D003424:Crohn Disease D003863:Depression D004195:Disease Models, Animal D004660:Encephalitis D006624:Hippocampus D007249:Inflammation D008297:Male D008928:Mitochondria D009569:Nitric Oxide
depression anxiety hippocampus toll-like receptor pathway Crohn’s disease oxidative stress