Geriatric-Oriented High Dose Nutraceutical ODTs: Formulation and Physicomechanical Characterization.
CONTEXT
Oral disintegrating tablets (ODTs) represent a better option than conventional tablets for geriatric population, owing to their fast onset of action and their better patient compliance.


OBJECTIVE
Two principal therapeutic high-dose nutraceuticals; chondroitin sulphate and glucosamine were formulated into an oral disintegration tablet (ODT) intended for sublingual administration, and optimized to improve compliance and achieve rapid onset of action in osteoarthritis treatment.


MATERIALS AND METHODS
Different formulations were prepared either by melt granulation or direct compression techniques. Excipients at different ratios such as superdisintegrants, pharmaburst™ C1, spray-dried mannitol, and polyethylene glycols were used to enhance the disintegration time for the ODT systems.


RESULTS
Although the ODT systems weighed around 1.3 gm with 60% drug load, some systems disintegrated within 2-3 min with 100% drug release. Pharmaburst™ C1 turned out to be the key excipient responsible for the superdisintegration properties of the ODTs. Dissolution enhancement of the two nutraceuticals could be achieved compared to the marketed conventional tablets.


CONCLUSION
The improved disintegration and dissolution properties of our prepared ODTs are expected to enhance the bioavailability of the high dose glucosamine and chondroitin sulphate in comparison with conventional tablets, which delineates them as a promising dosage form for the aforementioned nutraceuticals.
['Agiba|Ahmed M|AM|', 'Abdel-Hamid|Sameh|S|', 'Nasr|Maha|M|', 'Geneidi|Ahmed S|AS|']
D000284:Administration, Oral D001682:Biological Availability D002626:Chemistry, Pharmaceutical D019587:Dietary Supplements D065546:Drug Liberation D005079:Excipients D005944:Glucosamine D010003:Osteoarthritis D011092:Polyethylene Glycols D012995:Solubility D013607:Tablets
geriatric Chondroitin sulphate melt granulation direct compression glucosamine sulphate oral disintegrating
tablets.