"Not Just Right Experiences" as a psychological endophenotype for obsessive-compulsive disorder: Evidence from an Italian family study.
The heart of the obsessional process may be considered the subject's underlying impression that "something is wrong" or "that something is not just as it should be". This phenomenon, labeled "not just right experiences" (NJREs), has increasingly been receiving attention as a possible marker of obsessive-compulsive disorder (OCD). The present study sought to add to the evidence that NJREs may be a putative endophenotype of obsessional symptoms. To this aim, measures of NJREs, obsessive-compulsive (OC) symptoms and psychological distress were compared in offspring of parents with and without OC symptoms. The offspring of parents with OC symptoms (N=120) reported higher frequency and severity of NJREs compared to offspring of parents without OC symptoms (N=106). Such differences remained significant for NJREs frequency and close to significance for NJREs severity, when general distress (i.e., anxiety and depression) was controlled. The possible role of NJREs as an endophenotype for OCD is discussed in reference to Gottesman and Gould criteria and the National Institute of Mental Health RDoC initiative.
['Sica|Claudio|C|', 'Bottesi|Gioia|G|', 'Caudek|Corrado|C|', 'Orsucci|Antonella|A|', 'Ghisi|Marta|M|']
D000293:Adolescent D000328:Adult D000368:Aged D001008:Anxiety Disorders D001143:Arousal D016241:Child of Impaired Parents D003469:Culture D003866:Depressive Disorder D058068:Endophenotypes D005260:Female D006801:Humans D007558:Italy D008297:Male D008875:Middle Aged D009771:Obsessive-Compulsive Disorder D013001:Somatoform Disorders D011795:Surveys and Questionnaires D055815:Young Adult
Not just right experiences Endophenotype Obsessive-compulsive disorder Family study At risk population Research domain criterion