Comparison of multi-linear regression, particle swarm optimization artificial neural networks and genetic programming in the development of mini-tablets.
In the present study, the preparation of pharmaceutical mini-tablets was attempted in the framework of Quality by Design (QbD) context, by comparing traditionally used multi-linear regression (MLR), with artificially-intelligence based regression techniques (such as standard artificial neural networks (ANNs), particle swarm optimization (PSO) ANNs and genetic programming (GP)) during Design of Experiment (DoE) implementation. Specifically, the effect of diluent type and particle size fraction for three commonly used direct compression diluents (lactose, pregelatinized starch and dibasic calcium phosphate dihydrate, DCPD) blended with either hydrophilic or hydrophobic flowing aids was evaluated in terms of: a) powder blend properties (such as bulk (Y1) and tapped (Y2) density, Carr's compressibility index (Y3, CCI), Kawakita's compaction fitting parameters a (Y4) and 1/b (Y5)), and b) mini-tablet's properties (such as relative density (Y6), average weight (Y7) and weight variation (Y8)). Results showed better flowing properties for pregelatinized starch and improved packing properties for lactose and DPCD. MLR analysis showed high goodness of fit for the Y1, Y2, Y4, Y6 and Y8 with RMSE values of Y1 = 0.028, Y2 = 0.032, Y4 = 0.019, Y6 = 0.015 and Y8 = 0.130; while for rest responses, high correlation was observed from both standard ANNs and GP. PSO-ANNs fitting was the only regression technique that was able to adequately fit all responses simultaneously (RMSE values of Y1 = 0.026, Y2 = 0.022, Y3 = 0.025, Y4 = 0.010, Y5 = 0.063, Y6 = 0.013, Y7 = 0.064 and Y8 = 0.104).
['Barmpalexis|Panagiotis|P|', 'Karagianni|Anna|A|', 'Karasavvaides|Grigorios|G|', 'Kachrimanis|Kyriakos|K|']
D002130:Calcium Phosphates D004339:Drug Compounding D015195:Drug Design D005079:Excipients D007785:Lactose D016014:Linear Models D016571:Neural Networks, Computer D011208:Powders D013213:Starch D013607:Tablets
Genetic programming Mini-tablets Quality by design (QbD) Flow properties DoE optimization Particle swarm optimization ANNs