The Eating Disorders Genetics Initiative (EDGI): study protocol.
BACKGROUND
The Eating Disorders Genetics Initiative (EDGI) is an international investigation exploring the role of genes and environment in anorexia nervosa, bulimia nervosa, and binge-eating disorder.


METHODS
A total of 14,500 individuals with eating disorders and 1500 controls will be included from the United States (US), Australia (AU), New Zealand (NZ), and Denmark (DK). In the US, AU, and NZ, participants will complete comprehensive online phenotyping and will submit a saliva sample for genotyping. In DK, individuals with eating disorders will be identified by the National Patient Register, and genotyping will occur using bloodspots archived from birth. A genome-wide association study will be conducted within EDGI and via meta-analysis with other data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED).


DISCUSSION
EDGI represents the largest genetic study of eating disorders ever to be conducted and is designed to rapidly advance the study of the genetics of the three major eating disorders (anorexia nervosa, bulimia nervosa, and binge-eating disorder). We will explicate the genetic architecture of eating disorders relative to each other and to other psychiatric and metabolic disorders and traits. Our goal is for EDGI to deliver "actionable" findings that can be transformed into clinically meaningful insights.


TRIAL REGISTRATION
EDGI is a registered clinical trial: clinicaltrials.gov NCT04378101 .
['Bulik|Cynthia M|CM|http://orcid.org/0000-0001-7772-3264', 'Thornton|Laura M|LM|', 'Parker|Richard|R|', 'Kennedy|Hannah|H|', 'Baker|Jessica H|JH|', 'MacDermod|Casey|C|', 'Guintivano|Jerry|J|', 'Cleland|Lana|L|', 'Miller|Allison L|AL|', 'Harper|Lauren|L|', 'Larsen|Janne T|JT|', 'Yilmaz|Zeynep|Z|', 'Grove|Jakob|J|', 'Sullivan|Patrick F|PF|', 'Petersen|Liselotte V|LV|', 'Jordan|Jennifer|J|', 'Kennedy|Martin A|MA|', 'Martin|Nicholas G|NG|']
D001315:Australia D052018:Bulimia Nervosa D001068:Feeding and Eating Disorders D055106:Genome-Wide Association Study D006801:Humans D015201:Meta-Analysis as Topic D009520:New Zealand D014481:United States
Eating disorders Anorexia nervosa Bulimia nervosa Binge-eating disorder Genome-wide association Psychiatric genomics consortium Psychiatric genetics Social media