Clotting during autologous hematopoietic progenitor cells collection.
Autologous hematopoietic progenitor cell (HPC) transplant through peripheral blood mobilization and leukapheresis is a standard treatment for many patients with hematopoietic malignancies. Although leukapheresis is usually completed with no complications, we present a case in which the hematopoietic progenitor cells clotted during collection. The patient had no history of hypercoagulopathy. It was identified that the anticoagulant infusion line was partially constricted by a blood warmer clamp. The machine did not alarm. Most of the multiple Food and Drug Administration reports of clotting occurring during apheresis procedures were due to the patients' preexisting hypercoagulopathy or insufficient anticoagulant solution being used. The machine alarmed in most of these cases. Our case demonstrates that inadequate anticoagulation can occur during an HPC collection procedure without activation of an alarm.
['Gokhale|Amit|A|http://orcid.org/0000-0003-0748-4186', 'Quraishy|NurJehan|N|', 'Veemara|Viva|V|', 'Howdyshell|Heather|H|', 'Murray|Lynn|L|', 'Royer|Jennifer|J|', 'Salmi|Linda|L|', 'Ricci|Kristin|K|', 'Liu|Hien|H|']
D001777:Blood Coagulation D056902:Clinical Alarms D004868:Equipment Failure D005260:Female D018380:Hematopoietic Stem Cell Transplantation D006412:Hematopoietic Stem Cells D006801:Humans D007937:Leukapheresis D008875:Middle Aged D014182:Transplantation, Autologous
clotting hematopoietic progenitor cells collection anticoagulants apheresis