Prognostic value of total triiodothyronine and free thyroxine levels for the heart failure in patients with acute myocardial infarction.
BACKGROUND/AIMS
Although a low triiodothyronine (T3) state is closely associated with heart failure (HF), it is uncertain whether total T3 levels on admission is correlated with the clinical outcomes of acute myocardial infarction (AMI). The aim of this study is to investigate the prognostic value of total T3 levels for major adverse cardiovascular and cerebrovascular events (MACCEs) in patients with AMI undergone percutaneous coronary intervention (PCI).


METHODS
A total of 765 PCI-treated AMI patients (65.4 ± 12.6 years old, 215 women) between January 2012 and July 2014 were included and 1-year MACCEs were analyzed. We assessed the correlation of total T3 and free thyroxine (fT4) with prevalence of 1-year MACCEs and the predictive values of total T3, fT4, and the ratio of total T3 to fT4 (T3/fT4), especially for HF requiring re-hospitalization.


RESULTS
Thirty patients (3.9%) were re-hospitalized within 12 months to control HF symptoms. Total T3 levels were lower in the HF group than in the non-HF group (84.32 ± 21.04 ng/dL vs. 101.20 ± 20.30 ng/dL, p < 0.001). Receiver operating characteristic curve analysis showed the cut-offs of total T3 levels (≤ 85 ng/dL) and T3/fT4 (≤ 60) for HF (area under curve [AUC] = 0.734, p < 0.001; AUC = 0.774, p < 0.001, respectively). In multivariate analysis, lower T3/fT4 was an independent predictor for 1-year HF in PCI-treated AMI patients (odds ratio, 1.035; 95% confidential interval, 1.007 to 1.064; p = 0.015).


CONCLUSIONS
Lower levels of total T3 were well correlated with 1-year HF in PCI-treated AMI patients. The T3/fT4 levels can be an additional marker to predict HF.
['Kang|Min Gyu|MG|', 'Hahm|Jong Ryeal|JR|', 'Kim|Kye-Hwan|KH|', 'Park|Hyun-Woong|HW|', 'Koh|Jin-Sin|JS|', 'Hwang|Seok-Jae|SJ|', 'Hwang|Jin-Yong|JY|', 'Ahn|Jong Hwa|JH|', 'Park|Yongwhi|Y|', 'Jeong|Young-Hoon|YH|', 'Park|Jeong Rang|JR|', 'Kwak|Choong Hwan|CH|']
D000293:Adolescent D000368:Aged D005260:Female D006333:Heart Failure D006801:Humans D008875:Middle Aged D009203:Myocardial Infarction D062645:Percutaneous Coronary Intervention D011379:Prognosis D012189:Retrospective Studies D013974:Thyroxine D014284:Triiodothyronine
Triiodothyronine Heart failure Acute myocardial infarction Prognosis