The differential organogenesis and functionality of two liver-draining lymph nodes in mice.
The liver is an immunological organ. However, fundamental knowledge concerning liver-draining lymph nodes (LNs), which have been newly identified in mice as the portal and celiac LNs, is still lacking. Here, we revealed that the portal LN and celiac LN drain liver lymph through different lymphatic vessels. Although both the portal LN and celiac LN possess typical structures, they have different cell compositions. Interestingly, these two LNs form at different times during fetal development. Moreover, the organogenesis of the celiac LN, but not the portal LN, is controlled by the transcription factor NFIL3. Furthermore, the portal LN and celiac LN also perform different functions. The celiac LN is the predominant site of liver antiviral immune responses, whereas the portal LN functions in the in situ induction of dietary antigen-specific regulatory T cells. In conclusion, the portal LN and celiac LN are two independent liver-draining LNs with different organogenesis histories and separate functions in maintaining immune homeostasis in the liver.
['Yu|Jiali|J|', 'Chen|Yongyan|Y|', 'Wu|Yuzhang|Y|', 'Ye|Lilin|L|', 'Lian|Zhexiong|Z|', 'Wei|Haiming|H|', 'Sun|Rui|R|', 'Tian|Zhigang|Z|']
D000818:Animals D050976:Basic-Leucine Zipper Transcription Factors D002445:Celiac Artery D006801:Humans D007108:Immune Tolerance D007109:Immunity D053631:Interleukin Receptor Common gamma Subunit D008099:Liver D008198:Lymph Nodes D042601:Lymphatic Vessels D008216:Lymphocytic Choriomeningitis D008217:Lymphocytic choriomeningitis virus D008297:Male D051379:Mice D008810:Mice, Inbred C57BL D018345:Mice, Knockout D038081:Organogenesis D011169:Portal Vein
Organogenesis Celiac lymph node Immunotolerance Portal lymph node Viral infection