Fabrication of Aptamer-Modified Paper Electrochemical Devices for On-Site Biosensing.
Electrochemical aptamer-based (E-AB) sensors offer a powerful and general means for analyte detection in complex samples for various applications. Paper-based E-AB sensors could enable portable, low-cost, and rapid detection of a broad range of targets, but it has proven challenging to fabricate suitable three-electrode systems on paper. Here, we demonstrate a simple, economic, and environmentally friendly strategy for fabricating aptamer-modified paper electrochemical devices (PEDs) via ambient vacuum filtration. The material, shape, size, and thickness of the three-electrode PED system can be fully customized. We developed aptamer-modified PEDs that enable sensitive and specific detection of small molecules in minimally processed biosamples. The sensitivity and stability of the PEDs are comparable to E-AB sensors based on commercial gold electrodes. We believe our strategy can lead to the development of high performance PEDs for the on-site detection of a variety of analytes.
['Yu|Haixiang|H|', 'Chen|Zhimin|Z|', 'Liu|Yingzhu|Y|', 'Alkhamis|Obtin|O|', 'Song|Zhiping|Z|', 'Xiao|Yi|Y|0000-0001-7278-9811']
D052157:Aptamers, Nucleotide D015374:Biosensing Techniques D055664:Electrochemical Techniques D004566:Electrodes D006046:Gold D053768:Metal Nanoparticles D010209:Paper
paper electrochemical devices small molecules aptamers biosensors nanomaterials