Hyperandrogenism and phenotypes of polycystic ovary syndrome are not associated with differences in obstetric outcomes.
OBJECTIVES
To investigate obstetric outcomes in Danish women with different phenotypes of polycystic ovary syndrome (PCOS) and isolated hyperandrogenism (HA) and describe the risk of adverse obstetric outcomes in women with PCOS and HA compared to controls.


DESIGN
Cohort study.


SETTING
Odense University Hospital, Denmark.


POPULATION
Women with PCOS were identified prospectively starting in 1997. Singleton pregnancies in women with PCOS and HA during 2003-2011 were included (n = 199). A control group was matched to the patient cohort according to date of childbirth (n = 995).


METHODS
Data on clinical characteristics and obstetric outcomes were collected in patients with PCOS and HA and controls. In PCOS and HA, total and free testosterone, sex hormone binding globulin, and hemoglobin A1c were measured outside pregnancy. During pregnancy, oral glucose tolerance tests were performed in 39 patients and 123 controls according to Danish national guidelines. PCOS phenotypes were based on the Rotterdam criteria.


MAIN OUTCOME MEASURES
Gestational diabetes mellitus, pregnancy-induced hypertension, preeclampsia, delivery by emergency cesarean section, preterm delivery and anthropometric measures in the newborn.


RESULTS
The incidence of adverse obstetric outcomes and anthropometric measures among the newborns were comparable between different phenotypes of PCOS and patients with HA. In the oral glucose tolerance test, patients had a higher risk of gestational diabetes mellitus compared with controls; the odds ratio (95% confidence interval) was 3.3 (1.5-6.9) after adjustment for age, parity, and body mass index (p = 0.002). The incidence of other adverse obstetric outcomes was similar in patients and controls.


CONCLUSIONS
Obstetric outcomes were comparable in women with different PCOS phenotypes.
['Mumm|Hanne|H|', 'Jensen|Dorte Møller|DM|', 'Sørensen|Jens Aage|JA|', 'Andersen|Lise Lotte Torvin|LL|', 'Ravn|Pernille|P|', 'Andersen|Marianne|M|', 'Glintborg|Dorte|D|']
D000328:Adult D015992:Body Mass Index D005260:Female D006801:Humans D017588:Hyperandrogenism D007231:Infant, Newborn D010641:Phenotype D011085:Polycystic Ovary Syndrome D011247:Pregnancy D011256:Pregnancy Outcome D012738:Sex Hormone-Binding Globulin
hyperandrogenism Polycystic ovary syndrome obstetric outcomes testosterone hemoglobin A1c gestational diabetes mellitus polycystic ovary syndrome phenotypes