Chemical study of the strain Cordyceps spp. from cell fusion between Cordyceps militaris and Cordyceps cicadae.
Chemical investigation on the cultures of the fungus Cordyceps spp., a strain from cell fusion between Cordyceps militaris and Cordyceps cicadae, resulted in the isolation of 13 compounds including 2 new ones named 2-(5-(3-oxobutyl) furan-2-yl) acetic acid (1) and cordycepone (2). Their structures were elucidated from the analysis of 1D/2D NMR and CD data. Among them, compounds 1, 7-9, at a concentration of 50 μg/ml, showed weak inhibitory activity against AChE. Moreover, compounds 6, 9, and 11 showed moderate inhibitory activity against the nematode Panagrellus redivivus with mortality ratio of 79.0, 71.7, and 72.3% at 2.5 mg/ml, respectively.
['Yang|Ning-Ning|NN|', 'Jiang|Ning|N|', 'Ma|Qing-Yun|QY|', 'Kong|Fan-Dong|FD|', 'Xie|Qing-Yi|QY|', 'Zhou|Li-Man|LM|', 'Yu|Zhi-Fang|ZF|', 'Zhao|You-Xing|YX|']
D000110:Acetylcholinesterase D000818:Animals D000871:Anthelmintics D001681:Biological Assay D002459:Cell Fusion D002800:Cholinesterase Inhibitors D032661:Cordyceps D005663:Furans D015394:Molecular Structure D009348:Nematoda
spp AChE inhibitory activity Clavicipitaceae anti-nematode activity cyclic dipeptide lactone