Hashimoto's thyroiditis and papillary thyroid cancer: are they immunologically linked?
Hashimoto's thyroiditis (HT) is the most common autoimmune disease in humans frequently leading to hypothyroidism. HT is characterized by a cellular immune response with lymphatic infiltration of the thyroid gland by T and B cells, as well as by a humoral immune response leading to specific antibody production. The synchronous appearance of HT and papillary thyroid cancer (PTC) indicates an immunological link between the two entities. Three different pathomechanisms may be postulated, including preexisting autoimmunity leading to malignancy due to inflammation, immunity towards preexisiting tumor cells leading to specific autoimmunity, and immune tolerance leading to malignancy despite (auto)immunity. In this article we review data describing these potential mechanisms that might lead to the synchronous appearance of HT and PTC.
['Ehlers|Margret|M|', 'Schott|Matthias|M|']
D002277:Carcinoma D002291:Carcinoma, Papillary D050031:Hashimoto Disease D006801:Humans D007111:Immunity, Cellular D000077273:Thyroid Cancer, Papillary D013961:Thyroid Gland D013964:Thyroid Neoplasms
Hashimoto's thyroiditis cellular immunity thyroid gland papillary thyroid carcinoma