Interplay between interictal spikes and behavioral seizures in young, but not aged pilocarpine-treated epileptic rats.
Interictal spike activity is commonly observed in the EEG of patients with epilepsy, but the causal interrelationship between interictal spikes and behavioral seizures is poorly understood. We performed long-term video-EEG monitoring of 16 epileptic rats after pilocarpine-induced status epilepticus and five control animals. To quantify the interplay between periods of spikes and seizures, we calculated the time spent with spikes as well as the time spent with seizures for each animal. Within a given subject, we found a significant correlation between these two measures in 7/11 young epileptic rats (<400 days); this correlation was positive in six cases and negative in one. By contrast, none of five aged pilocarpine-treated animals exhibited significant correlation coefficients between spike periods and seizures (>600 days, P<0.05). Instead, aged epileptic rats showed a prominent predominance for either spike periods or seizures, which might explain the absence of significant correlation in this population. We found that there is a significant interplay between interictal periods of spikes and behavioral seizures in young epileptic animals, but this association is absent during aging.
['Bajorat|Rika|R|', 'Goerss|Doreen|D|', 'Brenndörfer|Linda|L|', 'Schwabe|Lars|L|', 'Köhling|Rüdiger|R|', 'Kirschstein|Timo|T|']
D000367:Age Factors D000818:Animals D000927:Anticonvulsants D004569:Electroencephalography D004827:Epilepsy D005260:Female D006801:Humans D008297:Male D010507:Periodicity D010862:Pilocarpine D051381:Rats D017207:Rats, Sprague-Dawley D012640:Seizures D013226:Status Epilepticus D013997:Time Factors D014741:Video Recording
Interictal spikes Long-term video-EEG Pilocarpine