Effects of glargine insulin on glycemic control in patients with diabetes mellitus type II undergoing off-pump coronary artery bypass graft.
Background
The prevalence of diabetes mellitus in patients requiring coronary artery bypass grafting (CABG) is noticeably high (20%-30%). These patients have inferior perioperative outcome, reduced long-term survival, and high risk of recurrent episodes of angina. To improve perioperative outcome surgical unit defined satisfactory glycemic control is desired during this period. Hence, the aim of our study is to compare the efficacy of glargine insulin combination with continuous human insulin infusion for perioperative glycemic control in patients with diabetes undergoing CABG.


Materials and Methods
Fifty Patients, who were posted for off-pump CABG with diabetes mellitus type II, were randomized in two group, Group I normal saline + human insulin infusion during the perioperative period, Group II (glargine group): Glargine + human insulin infusion during perioperative period.


Results
During surgery and in the postoperative period, random blood sugar and human insulin requirement are significantly higher in control group than glargine group. Other infection, step-up antibiotics, intensive care unit (ICU) stay, and hospital stay were significantly higher in control groups in postoperative period.


Conclusion
Our study results suggest that glargine effectively manages blood glucose level with significantly greater control over postoperative morbidity.
['Gandhi|Hemang|H|', 'Sarvaia|Alpesh|A|', 'Malhotra|Amber|A|', 'Acharya|Himanshu|H|', 'Shah|Komal|K|', 'Rajavat|Jeevraj|J|']
D000368:Aged D001786:Blood Glucose D047549:Coronary Artery Bypass, Off-Pump D003422:Critical Care D003924:Diabetes Mellitus, Type 2 D005260:Female D006801:Humans D007004:Hypoglycemic Agents D007262:Infusions, Intravenous D000069036:Insulin Glargine D007902:Length of Stay D008297:Male D008875:Middle Aged D019990:Perioperative Care D011183:Postoperative Complications D011446:Prospective Studies
glargine insulin Diabetes mellitus Type II off-pump coronary artery bypass grafting human insulin