Sources for Leads: Natural Products and Libraries.
Natural products have traditionally been a major source of leads in the drug discovery process. However, the development of high-throughput screening led to an increased interest in synthetic methods that enabled the rapid construction of large libraries of molecules. This resulted in the termination or downscaling of many natural product research programs, but the chemical libraries did not necessarily produce a larger amount of drug leads. On one hand, this chapter explores the current state of natural product research within the drug discovery process. On the other hand it evaluates the efforts made to increase the amount of leads generated from chemical libraries and considers what role natural products could play here.
['van Herwerden|Eric F|EF|', 'Süssmuth|Roderich D|RD|']
D000818:Animals D001688:Biological Products D020650:Combinatorial Chemistry Techniques D055808:Drug Discovery D006801:Humans D060847:Metabolic Engineering
Natural products Drug discovery Diversity-oriented synthesis Fragment-based drug discovery Privileged structures Unexplored natural product sources