Association study of functional polymorphisms in interleukins and interleukin receptors genes: IL1A, IL1B, IL1RN, IL6, IL6R, IL10, IL10RA and TGFB1 in schizophrenia in Polish population.
Schizophrenia has been associated with a large range of autoimmune diseases, with a history of any autoimmune disease being associated with a 45% increase in risk for the illness. The inflammatory system may trigger or modulate the course of schizophrenia through complex mechanisms influencing neurodevelopment, neuroplasticity and neurotransmission. In particular, increases or imbalance in cytokine before birth or during the early stages of life may affect neurodevelopment and produce vulnerability to the disease. A total of 27 polymorphisms of IL1N gene: rs1800587, rs17561; IL1B gene: rs1143634, rs1143643, rs16944, rs4848306, rs1143623, rs1143633, rs1143627; IL1RN gene: rs419598, rs315952, rs9005, rs4251961; IL6 gene: rs1800795, rs1800797; IL6R gene: rs4537545, rs4845617, rs2228145, IL10 gene: rs1800896, rs1800871, rs1800872, rs1800890, rs6676671; IL10RA gene: rs2229113, rs3135932; TGF1B gene: rs1800469, rs1800470; each selected on the basis of molecular evidence for functionality, were investigated in this study. Analysis was performed on a group of 621 patients with diagnosis of schizophrenia and 531 healthy controls in Polish population. An association of rs4848306 in IL1B gene, rs4251961 in IL1RN gene, rs2228145 and rs4537545 in IL6R with schizophrenia have been observed. rs6676671 in IL10 was associated with early age of onset. Strong linkage disequilibrium was observed between analyzed polymorphisms in each gene, except of IL10RA. We observed that haplotypes composed of rs4537545 and rs2228145 in IL6R gene were associated with schizophrenia. Analyses with family history of schizophrenia, other psychiatric disorders and alcohol abuse/dependence did not show any positive findings. Further studies on larger groups along with correlation with circulating protein levels are needed.
['Kapelski|Pawel|P|', 'Skibinska|Maria|M|', 'Maciukiewicz|Malgorzata|M|', 'Wilkosc|Monika|M|', 'Frydecka|Dorota|D|', 'Groszewska|Agata|A|', 'Narozna|Beata|B|', 'Dmitrzak-Weglarz|Monika|M|', 'Czerski|Piotr|P|', 'Pawlak|Joanna|J|', 'Rajewska-Rager|Aleksandra|A|', 'Leszczynska-Rodziewicz|Anna|A|', 'Slopien|Agnieszka|A|', 'Zaremba|Dorota|D|', 'Twarowska-Hauser|Joanna|J|']
D000328:Adult D005190:Family D005260:Female D056726:Genetic Association Studies D020022:Genetic Predisposition to Disease D006239:Haplotypes D006801:Humans D053590:Interleukin 1 Receptor Antagonist Protein D007378:Interleukins D015810:Linkage Disequilibrium D008297:Male D011044:Poland D020641:Polymorphism, Single Nucleotide D018123:Receptors, Interleukin D012559:Schizophrenia D053773:Transforming Growth Factor beta1 D044465:Whites
Association Functional polymorphism Interleukin Interleukin receptor