Ovarian cavity fluid of the viviparous surfperch Neoditrema ransonnetii suppresses the spontaneous cytotoxic activity of head-kidney leucocytes against xenogeneic targets.
In this study, the effect of ovarian cavity fluid (OCF) from a surfperch Neoditrema ransonnetii on the cytotoxic activity of leucocytes was investigated. In an assay targeting RTG-2, a cell line derived from rainbow trout Oncorhynchus mykiss gonads, leucocytes from both the spleen and head kidney showed spontaneous killing activity. Pre-incubation with OCF significantly suppressed the cytotoxic activity of head-kidney leucocytes towards RTG-2. This suppressive activity was due to the presence of low molecular-mass materials. These results suggest that OCF plays significant roles in pregnancy by its ability to modulate cytotoxicity with maternal leucocytes.
['Yokozawa|N|N|', 'Nakamura|O|O|', 'Saito|E|E|', 'Tsutsui|S|S|']
D000818:Animals D001826:Body Fluids D002460:Cell Line D003601:Cytotoxicity Tests, Immunologic D005260:Female D060226:Head Kidney D007962:Leukocytes D010053:Ovary D010473:Perciformes D052286:Viviparity, Nonmammalian
viviparity cytotoxicity RTG-2 immunosuppression okitango