Cornstarch-based wound dressing incorporated with hyaluronic acid and propolis: In vitro and in vivo studies.
The unique physicochemical and functional characteristics of starch-based biomaterials and wound dressings have been proposed for several biomedical applications. Film dressings of cornstarch/hyaluronic acid/ ethanolic extract of propolis (CS/HA/EEP) were prepared by solvent-casting and characterized by attenuated total reflectance/Fourier transform infrared spectroscopy, scanning electron microscopy, gas chromatography/mass spectrometry, light transmission, opacity measurements, EEP release, equilibrium swelling, and in vitro and in vivo evaluations. The CS/HA/0.5%EEP film dressing exhibited higher antibacterial activity against Staphylococcus aureus (2.08 ± 0.14 mm), Escherichia coli (2.64 ± 0.18 mm), and Staphylococcus epidermidis (1.02 ± 0.15 mm) in comparison with the CS, CS/HA, and CS/HA/0.25%EEP films. Also, it showed no cytotoxicity for the L929 fibroblast cells. This wound dressing could effectively accelerate the wound healing process at Wistar rats' skin excisions. These results indicate that enrichment of cornstarch wound dressings with HA and EEP can significantly enhance their potential efficacy as wound dressing material.
['Eskandarinia|Asghar|A|', 'Kefayat|Amirhosein|A|', 'Rafienia|Mohammad|M|', 'Agheb|Maria|M|', 'Navid|Sepehr|S|', 'Ebrahimpour|Karim|K|']
D000818:Animals D000900:Anti-Bacterial Agents D002645:Chickens D004926:Escherichia coli D005260:Female D005347:Fibroblasts D006820:Hyaluronic Acid D006868:Hydrolysis D009113:Muramidase D009779:Occlusive Dressings D011429:Propolis D017208:Rats, Wistar D013211:Staphylococcus aureus D013212:Staphylococcus epidermidis D013213:Starch D014945:Wound Healing
Hyaluronic acid Propolis Cornstarch Wound healing