Morphologic Change of Parvalbumin-positive Myelinated Axons in the Human Dental Pulp.
INTRODUCTION
Information on the nerve fibers innervating the dental pulp is crucial for understanding dental pain and hypersensitivity. This study investigated the morphologic differences of parvalbumin (PV)-positive (+) myelinated fibers in 3 different regions of the human dental pulp.


METHODS
Light and electron microscopic immunohistochemistry for parvalbumin, a marker for myelinated fibers, and quantitative analysis were performed in the apical root, core of coronal pulp, and peripheral pulp of human premolar teeth.


RESULTS
About 40% of the myelinated fibers in the apical root pulp became unmyelinated in the core of the coronal pulp, and virtually all the remaining fibers became unmyelinated at the peripheral pulp. The size of myelinated axons decreased from root to peripheral pulp. PV+ axons showed extensive axonal varicosities in the peripheral pulp.


CONCLUSIONS
These findings suggest that the myelinated fibers innervating the human dental pulp undergo extensive morphologic change in the extrapulpal region and in the coronal and peripheral pulp, and that PV-mediated regulation of calcium concentration and its downstream events may occur primarily in axonal varicosities in the peripheral pulp.
['Kim|Tae Heon|TH|', 'Park|Sook Kyung|SK|', 'Choi|So Young|SY|', 'Lee|Jae Sik|JS|', 'Bae|Yong Chul|YC|']
D000293:Adolescent D000328:Adult D001369:Axons D003782:Dental Pulp D006801:Humans D008854:Microscopy, Electron D009413:Nerve Fibers, Myelinated D010320:Parvalbumins D055815:Young Adult
myelinated axon Dental pulp parvalbumin ultrastructure