Achieving simplified disease activity index remission in patients with active rheumatoid arthritis is associated with subsequent good functional and structural outcomes in a real-world clinical setting under a treat-to-target strategy.
OBJECTIVE
To verify predictive validity of simplified disease activity index (SDAI) remission for subsequent functional and structural outcomes in real-world clinical settings under a treat-to-target strategy (T2T).


METHODS
In this multicenter, prospective cohort study, T2T was implemented in rheumatoid arthritis (RA) patients with moderate-to-high disease activity. SDAI or clinical disease activity index (CDAI) was assessed every 12 weeks, and treatment was adjusted to achieve clinical remission or low disease activity (LDA). Multivariate logistic regression models were used to examine the associations of SDAI remission (≤3.3) at week 24 with the health assessment questionnaire-disability index (HAQ-DI) ≤ 0.5 or with the delta van der Heijde-modified total Sharp score (ΔvdH-mTSS) <smallest detectable change (SDC) at week 72.


RESULTS
Of 318 patients enrolled, 271 completed the follow-up for 72 weeks and were subjects of the analyses. Factors [odds ratio (95% confidence interval)] significantly associated with the HAQ-DI ≤0.5 were SDAI remission at week 24 [2.99 (1.42-6.28), p = 0.004], baseline HAQ-DI [0.28 (0.18-0.45), p = 1.3 × 10-7], and baseline vdH-mTSS [0.986 (0.976-0.996), p = 0.009]. A factor associated with ΔvdH-mTSS < SDC was SDAI remission at week 24 [3.53 (1.62-7.71), p = 0.002].


CONCLUSION
Predictive validity of SDAI remission for good outcomes was verified in a T2T-implementing cohort in the current clinical settings.
['Hirano|Fumio|F|', 'Yokoyama|Waka|W|', 'Yamazaki|Hayato|H|', 'Amano|Koichi|K|', 'Kawakami|Atsushi|A|', 'Hayashi|Taichi|T|', 'Tamura|Naoto|N|', 'Yasuda|Shinsuke|S|', 'Dobashi|Hiroaki|H|', 'Fujii|Takao|T|', 'Ito|Satoshi|S|', 'Kaneko|Yuko|Y|', 'Matsui|Toshihiro|T|', 'Okuda|Yasuaki|Y|', 'Saito|Kazuyoshi|K|', 'Suzuki|Fumihito|F|', 'Yoshimi|Ryusuke|R|', 'Sakai|Ryoko|R|', 'Koike|Ryuji|R|', 'Kohsaka|Hitoshi|H|', 'Miyasaka|Nobuyuki|N|', 'Harigai|Masayoshi|M|', '|||']
D000328:Adult D000368:Aged D018501:Antirheumatic Agents D001172:Arthritis, Rheumatoid D005260:Female D006801:Humans D007564:Japan D008297:Male D008875:Middle Aged D062072:Patient Acuity D011237:Predictive Value of Tests D011379:Prognosis D011446:Prospective Studies D020127:Recovery of Function D012074:Remission Induction D012720:Severity of Illness Index D016896:Treatment Outcome
Simplified disease activity index Rheumatoid arthritis Treat-to-target Health assessment questionnaire Modified Sharp score