HLA concordance between hematopoietic stem cell transplantation patients and umbilical cord blood units: Implications for cord blood banking in admixed populations.
Umbilical cord blood stem cell transplantation is an important choice for treating a variety of hematopoietic, neoplastic, and genetic disorders. The optimal size for a cord blood bank to provide matching units for 80% of patients requiring a stem cell transplantation procedure depends on the particular characteristics of each population. In this study, we analyzed the immunogenetic diversity of a sample set of Mexican patients suffering from blood, hematopoietic, and immunological diseases, to assess the best strategy for cord blood banking. For achieving that, we analyzed HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1 genotype and allele frequencies of both units from the bioarchive of the Umbilical Cord Blood Bank from La Raza and patients requiring a stem cell transplant and compared these variables with data from the same geographic and genetic context. We were able to detect significant differences for at least half of the alleles were observed for HLA class I and class II genes between units and patients. Five Native American haplotypes had lower frequencies in patients sample than in the cord blood units. Genetic admixture estimations for both groups showed a higher contribution of Native American component in the cord blood units. Differences in ancestral components in the Umbilical Cord Blood Bank from La Raza and six virtual banks modeled from a pool of Mexican mixed ancestry individuals show that genetic background is important in cord blood collection. In conclusion, increasing diversity over quantity of new cord blood units will improve the cost effectiveness of cord blood banking and health policies regarding hematopoietic stem cell transplantation in admixed populations such as those present in Latin American countries.
['Bravo-Acevedo|Alicia|A|', 'Barquera|Rodrigo|R|', 'Bekker-Méndez|Carolina|C|', 'Clayton|Stephen|S|', 'Hernández-Zaragoza|Diana Iraíz|DI|', 'Benítez-Arvizu|Gamaliel|G|', 'Guerra-Márquez|Ángel|Á|', 'Juárez-Cortés|Eva Dolores|ED|', 'Arriaga-Perea|Agustín Jericó|AJ|', 'Novelo-Garza|Bárbara|B|']
D000293:Adolescent D000328:Adult D000483:Alleles D001771:Blood Banks D002648:Child D002675:Child, Preschool D036101:Cord Blood Stem Cell Transplantation D005260:Female D005312:Fetal Blood D005787:Gene Frequency D005805:Genes, MHC Class I D005802:Genes, MHC Class II D014644:Genetic Variation D006680:HLA Antigens D006239:Haplotypes D018380:Hematopoietic Stem Cell Transplantation D006650:Histocompatibility Testing D006801:Humans D008297:Male D008800:Mexico D066027:Transplant Recipients D055815:Young Adult
HLA Umbilical cord blood banking Ancestral genetic components Linkage disequilibrium Mexico Population immunogenetics