Impact of letrozole versus clomiphene citrate on endometrial receptivity in Iraqi women with polycystic ovarian syndrome.
WHAT IS KNOWN AND OBJECTIVES
Letrozole is widely known for its use as an ovulation inductor. This study aims to investigate the effects of letrozole and clomiphene citrate in females with polycystic ovarian syndrome.


METHODS
This is a randomized non-blinded controlled trial study that included 80 infertile females with polycystic ovarian syndrome receiving a standard dose of either clomiphene citrate or letrozole on day 2 of the cycle. An ultrasound was done to examine growth of the follicle, endometrial thickness on days 12-13, and a Doppler study to measure resistance index (RI), pulsatility index and ratio of systolic/diastolic velocity.


RESULTS AND DISCUSSION
The mean levels of dominant follicle and oestradiol were significantly higher in the clomiphene citrate group than in the letrozole group. The letrozole group had a significantly greater endometrial thickness than the clomiphene citrate group. The resistance index and pulsatility index were lower in the letrozole group and in pregnant women than in the clomiphene citrate group and the non-pregnant group.


WHAT IS NEW AND CONCLUSION
The use of letrozole for ovulation induction in polycystic ovarian syndrome patients has a better effect on endometrial receptivity markers when compared to clomiphene citrate.
['Al-Obaidi|Manal T|MT|', 'Ali|Zainab H|ZH|', 'Al-Saadi|Wasan I|WI|', 'Al-Wasiti|Estabraq A R|EAR|', 'Al-Aubaidy|Hayder|H|https://orcid.org/0000-0001-9564-0120']
D000328:Adult D047072:Aromatase Inhibitors D002996:Clomiphene D004717:Endometrium D005260:Female D006801:Humans D007247:Infertility, Female D000077289:Letrozole D006080:Ovarian Follicle D010062:Ovulation Induction D011085:Polycystic Ovary Syndrome D011446:Prospective Studies
letrozole clomiphene citrate polycystic ovarian syndrome resistance index pulsatility index vascular endothelium growth factor