LAMP3 expression correlated with poor clinical outcome in human ovarian cancer.
Lysosome-associated membrane protein 3 belongs to the lysosome-associated membrane glycoprotein family, which is associated with lymph node, metastasis, poor overall survival, and resistance to chemotherapy and radiotherapy. Epithelial ovarian cancer is one of the most deadly global female gynecologic malignant tumors. Its clinical outcome is poor and most epithelial ovarian cancer patients tend to relapse because of drug resistance. However, lysosome-associated membrane protein 3 expression in epithelial ovarian cancer and its relationship between clinicopathologic factors remain poorly understood. To clarify the prognostic implications of lysosome-associated membrane protein 3 in epithelial ovarian cancer, we analyzed both messenger RNA and protein levels of lysosome-associated membrane protein 3 in ovarian carcinomas. Polymerase chain reaction results showed higher expression of lysosome-associated membrane protein 3 messenger RNA in epithelial ovarian cancer than in noncancerous tissues. Immunohistochemical results showed that high lysosome-associated membrane protein 3 cytoplasmic expression was significantly related to tumor grade ( p = 0.038), lymph node metastasis ( p = 0.049), metastasis ( p < 0.001), level of CA125 ( p = 0.030), and International Federation of Gynecology and Obstetrics (FIGO) ( p < 0.001). High lysosome-associated membrane protein 3 nuclear expression was significantly associated with tumor grade ( p = 0.046), tumor single or double (representative whether the tumor involving one or both ovaries) ( p = 0.016), metastasis ( p < 0.001), and FIGO stage ( p < 0.001). Survival analysis indicated that high lysosome-associated membrane protein 3 cytoplasmic expression (hazard ratio: 4.632, 95% confidence interval: 2.421-8.864; p < 0.001), patients' age (hazard ratio: 1.729, 95% confidence interval: 1.027-2.911; p = 0.039), and FIGO stage (hazard ratio: 2.049, 95% confidence interval: 1.113-3.774; p = 0.021) were significantly correlated with poor survival outcome of epithelial ovarian cancer patients.
['Wang|Di|D|', 'Cao|Xuemin|X|', 'Zhang|Yuquan|Y|', 'Liu|Yuanlin|Y|', 'Yao|Chan|C|', 'Ge|Wenliang|W|', 'Xu|Yunzhao|Y|']
D000368:Aged D005260:Female D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008198:Lymph Nodes D008207:Lymphatic Metastasis D051907:Lysosome-Associated Membrane Glycoproteins D008875:Middle Aged D009362:Neoplasm Metastasis D009363:Neoplasm Proteins D009364:Neoplasm Recurrence, Local D009367:Neoplasm Staging D010051:Ovarian Neoplasms D011379:Prognosis D016019:Survival Analysis
Lysosome-associated membrane protein 3 epithelial ovarian cancer gynecologic malignancy prognosis