Risk factors for early postoperative complications in patients with Crohn's disease after colorectal surgery other than ileocecal resection or right hemicolectomy.
PURPOSE
To evaluate risk factors for early postoperative complications in patients with Crohn's disease (CD) after extensive colorectal resection excluding mere ileocecal resection or right hemicolectomy at a university center.


METHODS
A retrospective analysis of the prospectively maintained database for surgical patients with CD at our institution was performed. All consecutive patients operated between December 2009 and December 2017 were included.


RESULTS
In total, 126 patients were eligible for this study. Most common types of operations performed were subtotal colectomy or proctocolectomy (37.3%) and resections of the rectum (34.1%) or the sigmoid colon (14.3%). Major postoperative complications occurred in 29 patients (23.0%). The rate of local septic complications (anastomotic leak, postoperative abscess) was 11.1%. In univariate analysis, low preoperative albumin, elevated preoperative C-reactive protein (CRP), and emergency surgery were factors associated with major postoperative complications. When multivariable analysis was performed, low preoperative albumin was the only independent risk factor for the occurrence of major postoperative complications (p = 0.0033; OR 0.899). The cut-off value for albumin was 32.6 g/L.


CONCLUSIONS
In this large cohort of consecutive patients undergoing surgery of the colorectum in CD, the rate of major postoperative complications was considerably higher compared to our recently published data from patients with ileocecal resection or right hemicolectomy. Preoperative albumin is the only independent risk factor for the occurrence of major postoperative complications. Preoperative albumin levels > 32.6 g/L significantly reduce the risk for postoperative complications.
['Galata|Christian|C|', 'Kienle|Peter|P|', 'Weiss|Christel|C|', 'Seyfried|Steffen|S|', 'Reißfelder|Christoph|C|', 'Hardt|Julia|J|']
D000328:Adult D000418:Albumins D003082:Colectomy D003107:Colorectal Surgery D003424:Crohn Disease D005260:Female D006801:Humans D007080:Ileocecal Valve D008297:Male D011183:Postoperative Complications D011300:Preoperative Care D012372:ROC Curve D012307:Risk Factors
Postoperative complications Colectomy Anastomotic leak Crohn’s disease Left hemicolectomy Rectal surgery