MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity.
MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plasticity. To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the intracellular pathways that mediate experience-dependent changes in the brain.
['Capitano|F|F|', 'Camon|J|J|', 'Licursi|V|V|', 'Ferretti|V|V|', 'Maggi|L|L|', 'Scianni|M|M|', 'Del Vecchio|G|G|', 'Rinaldi|A|A|', 'Mannironi|C|C|', 'Limatola|C|C|', 'Presutti|C|C|', 'Mele|A|A|']
D000818:Animals D006624:Hippocampus D008297:Male D057567:Memory, Long-Term D051379:Mice D035683:MicroRNAs D009473:Neuronal Plasticity D065853:Spatial Learning D065852:Spatial Memory
LTP Mice Morris water maze