Polyamines alleviate the inhibitory effect of the DNA cross-linking agent mitomycin C on root growth.
Polyamines (putrescine, spermidine and spermine) are ubiquitously present in various types of cells of living organisms. They are involved in a variety of cellular processes, including cell proliferation and cell differentiation, and are required for abiotic stress tolerances in plants. However, it is still not understood whether polyamines are involved in the plant growth inhibition caused by DNA-damaging agents. In this study, we examined the effects of polyamines on the inhibition of plant root growth and gene expression in Arabidopsis thaliana treated with mitomycin C (MMC), a genotoxic agent that induces DNA interstrand crosslinks. We found that polyamines alleviated the inhibitory effect caused by MMC on root growth. In addition, we also found that polyamines alleviated the increased expression of AtBRCA1 and AtRAD51 genes induced by MMC treatment. Our study provides the first evidence that polyamines contribute to tolerance against plant-growth inhibition caused by a DNA-damaging chemical.
['Tanaka|Hidenori|H|', 'Takeda|Kazuya|K|', 'Imai|Akihiro|A|0000-0001-7226-488X']
D017360:Arabidopsis D003432:Cross-Linking Reagents D004249:DNA Damage D018506:Gene Expression Regulation, Plant D016685:Mitomycin D018517:Plant Roots D011073:Polyamines D011700:Putrescine D013095:Spermidine D013096:Spermine
Polyamine mitomycin C root growth Arabidopsis thaliana DNA damage