Modulatory effect of zingerone against cisplatin or γ-irradiation induced hepatotoxicity by molecular targeting regulation.
Zingerone (ZO) is an ingredient of ginger (Zingiber officinale) which has different pharmacological properties. The objective of this research was to evaluate the protective effect of ZO against Cisplatin (Cis) or γ-Irradiation (IR)-induced hepatotoxicity in rats. ZO was given orally for consecutive 14 days prior to the treatment with Cis or exposure to IR at 15th day. Animals were sacrificed at the 23rd day. Cis or IR induced a marked increase in MAPK signal transduction as evidenced by increased p38 MAPK, JNK and ErK1/2. CYP2E1 and NADPH oxidase were significantly up-regulated. Inflammatory markers (TLR4, iNOS, COX-2 and MPO) and liver enzymes (AST, ALT and ALP) activities were also increased. Administration of ZO significantly ameliorated the above mentioned parameters.
['Mohamed|Hebatallah E|HE|', 'Badawy|Monda M M|MMM|']
D000410:Alanine Transaminase D000469:Alkaline Phosphatase D000818:Animals D001219:Aspartate Aminotransferases D002945:Cisplatin D019392:Cytochrome P-450 CYP2E1 D005720:Gamma Rays D015870:Gene Expression D006139:Guaiacol D018836:Inflammation Mediators D008099:Liver D020935:MAP Kinase Signaling System D008297:Male D058990:Molecular Targeted Therapy D020011:Protective Agents D011837:Radiation-Protective Agents D051381:Rats
Zingerone Cisplatin γ-Irradiation Hepatotoxicity MAPK CYP2E1 TLR4