Quassinoids from the Roots of Eurycoma longifolia and Their Anti-Proliferation Activities.
A phytochemical investigation on the roots of medicinal plant Eurycoma longifolia resulted in the isolation of 10 new highly oxygenated C20 quassinoids longifolactones G‒P (1-10), along with four known ones (11-14). Their chemical structures and absolute configurations were unambiguously elucidated on the basis of comprehensive spectroscopic analysis and X-ray crystallographic data. Notably, compound 1 is a rare pentacyclic C20 quassinoid featuring a densely functionalized 2,5-dioxatricyclo[5.2.2.04,8]undecane core. Compound 4 represents the first example of quassinoids containing a 14,15-epoxy functionality, and 7 features an unusual α-oriented hydroxyl group at C-14. All isolated compounds were evaluated for their anti-proliferation activities on human leukemia cells. Among the isolates, compounds 5, 12, 13, and 14 potently inhibited the in vitro proliferation of K562 and HL-60 cells with IC50 values ranging from 2.90 to 8.20 μM.
['Yang|Wei-Qun|WQ|', 'Tang|Wei|W|', 'Huang|Xiao-Jun|XJ|', 'Song|Jian-Guo|JG|0000-0003-3843-355X', 'Li|Yue-Yue|YY|', 'Xiong|Yu|Y|', 'Fan|Chun-Lin|CL|', 'Wu|Zhen-Long|ZL|', 'Wang|Ying|Y|0000-0003-4524-1812', 'Ye|Wen-Cai|WC|']
quassinoids Eurycoma longifolia anti-proliferation activities Simaroubaceae natural products