The role of visfatin in pathogenesis of gestational diabetes (GDM).
Gestational diabetes (GDM) is defined as a glucose intolerance of varying severity with onset or first recognition during pregnancy. Two major metabolic disorders: insulin resistance and β-cells dysfunction, play currently major role in pathogenesis of GDM. Adipose tissue is an organ involved in production of adipokines, which have various influence on metabolism of glucose and lipids. Visfatin is an adipokine mainly produced and secreted by the fat tissue. It exerts an insulin-like effect by binding to the insulin receptor-1 and have hypoglycemic effect. Visfatin appears to be an important factor in the pathophysiology of GDM. The aim of this article is to review the literature concerning the relationship between the adipokine mentioned above and GDM, and to clarify its role in the pathophysiology of GDM.
['Radzicka|Sandra|S|', 'Pietryga|Marek|M|', 'Iciek|Rafal|R|', 'Brązert|Jacek|J|']
D000273:Adipose Tissue D000818:Animals D001786:Blood Glucose D016207:Cytokines D016640:Diabetes, Gestational D005260:Female D006801:Humans D007328:Insulin D007333:Insulin Resistance D050417:Insulin-Secreting Cells D054409:Nicotinamide Phosphoribosyltransferase D011247:Pregnancy
visfatin GDM NAMPT adipocytokines gestational diabetes mellitus