Regulated Drug Release Abilities of Calcium Carbonate-Gelatin Hybrid Nanocarriers Fabricated via a Self-Organizational Process.
In this study, we investigated the drug-releasing behavior of a calcium carbonate (CaCO3 )-gelatin hybrid nanocarrier, fabricated through a single process using biomimetic mineralization. The organic scaffold (gelatin) of the fabricated nanocarrier is responsible for its capacity to load anionic drugs and for controlling the morphology of the inorganic matrix (CaCO3 ). We studied the drug-releasing properties of the nanocarrier by investigating the response of the CaCO3 matrix to acidic conditions. We found that under neutral conditions, drug release from the nanocarrier was inhibited, whereas under acidic conditions, the drug was efficiently released. Therefore, drug release from the nanocarrier is largely dependent on the surrounding pH.
['Murai|Kazuki|K|0000-0002-6916-464X', 'Kurumisawa|Kazuya|K|', 'Nomura|Yoshihiro|Y|', 'Matsumoto|Mutsuyoshi|M|']
D000838:Anions D002119:Calcium Carbonate D004337:Drug Carriers D065546:Drug Liberation D005780:Gelatin D006863:Hydrogen-Ion Concentration D018625:Microscopy, Atomic Force D053758:Nanoparticles D004364:Pharmaceutical Preparations D017550:Spectroscopy, Fourier Transform Infrared D013696:Temperature D013818:Thermogravimetry
gelatin biomineralization controlled release drug delivery pH responsivity