Excess stroke incidence in young Aboriginal people in South Australia: Pooled results from two population-based studies.
Background Retrospective data indicate increased stroke incidence in Aboriginal/Torres Strait Islander (Indigenous) Australians, possibly with poorer outcomes. We present the first prospective population-based stroke incidence study in Indigenous Australians. Methods We pooled data from ASCEND and SEARCH, two prospective "ideal" South Australian stroke incidence studies, ASCEND conducted in urban Northwestern Adelaide (2009-2010) and SEARCH in five South Australian rural centers (2009-2011). We calculated age-standardized incidence for Aboriginal and non-Aboriginal people. Results The study population comprised 261,403 inhabitants. Among 432 first-ever strokes, 13 were in Aboriginal people (median age 51 vs. 78 years for non-Aboriginal people, p < 0.001). Age-standardized stroke incidence per 100,000 in Aboriginal patients (116, 95% CI: 95-137) was nearly two-fold that of non-Aboriginal patients (67, 95% CI: 51-84). Age-stratified excess incidence in Aboriginal people was restricted to those aged < 55 years (incidence rate ratio (IRR) 3.5, 95% CI: 2-7), particularly for intracerebral hemorrhage (IRR: 16, 95% CI: 4-61). Conclusion The excess stroke incidence in Aboriginal South Australians appears substantial, especially in those aged <55 years. Further work is required to delineate and address disparities.
['Balabanski|Anna H|AH|', 'Newbury|Jonathan|J|', 'Leyden|James M|JM|', 'Arima|Hisatomi|H|', 'Anderson|Craig S|CS|', 'Castle|Sally|S|', 'Cranefield|Jennifer|J|', 'Paterson|Tracey|T|', 'Thrift|Amanda G|AG|0000-0001-8533-4170', 'Katzenellenbogen|Judith|J|', 'Brown|Alex|A|', 'Kleinig|Timothy J|TJ|']
D000293:Adolescent D000328:Adult D000367:Age Factors D000368:Aged D001315:Australia D002543:Cerebral Hemorrhage D015331:Cohort Studies D005260:Female D006801:Humans D015994:Incidence D008297:Male D008875:Middle Aged D011446:Prospective Studies D012424:Rural Population D013021:South Australia D020521:Stroke D055815:Young Adult
Stroke Aboriginal epidemiology hemorrhagic stroke ischemic stroke