Leukoaraiosis and lacunes are associated with poor clinical outcomes in ischemic stroke patients treated with intravenous thrombolysis.
BACKGROUND
The effect of preexisting small vessel disease on outcomes of patients with ischemic stroke treated with i.v. thrombolysis is not fully understood.


AIM
We aim to investigate the effect of combined leukoaraiosis and lacunes as detected on unenhanced brain computer tomography at baseline on clinical outcomes after i.v. thrombolysis.


METHODS
We analyzed data from the Canadian Alteplase for Stroke Effectiveness Study. Small vessel disease was assessed on baseline computer tomography rating for leukoaraiosis and lacunes. We dichotomized the burden of small vessel disease to "absent or moderate" and "severe." Clinical outcomes at 90 days included excellent outcome (mRS = 0-1), good outcome (mRS = 0-2), and the occurrence of symptomatic intracerebral hemorrhage. Sensitivity analysis was performed on two age groups (≤80 versus >80). We ran logistic regression adjusting for confounders to evaluate independent effect of small vessel disease on outcomes.


RESULTS
There were 820 patients with available brain computer tomography with mean age (±SD) of 71.3 (±13.2), 455 (55.5%) were male. Of these, 123 (15%) patients had severe small vessel disease at baseline. Age group analysis revealed significant associations of small vessel disease only in patients aged ≤80. After adjustment for confounders, presence of severe small vessel disease reduced the chances of both excellent (OR = 0.42, 95% CI = 0.24-0.74) and good outcome (OR = 0.35, 95% CI = 0.21-0.58) and with an increased risk of symptomatic intracerebral hemorrhage (OR = 5.91; 95% CI = 2.40-14.57).


CONCLUSION
When considered together as radiological expressions of small vessel disease, presence and severity of severe leukoaraiosis and lacunes on baseline computer tomography scan are associated with poor clinical outcomes in patients treated with i.v. thrombolysis.
['Arba|Francesco|F|', 'Palumbo|Vanessa|V|', 'Boulanger|Jean-Martin|JM|', 'Pracucci|Giovanni|G|', 'Inzitari|Domenico|D|', 'Buchan|Alastair M|AM|', 'Hill|Michael D|MD|', '|||']
D061605:Administration, Intravenous D000368:Aged D001921:Brain D002545:Brain Ischemia D002170:Canada D005260:Female D005343:Fibrinolytic Agents D006801:Humans D049292:Leukoaraiosis D016015:Logistic Models D008297:Male D011379:Prognosis D012680:Sensitivity and Specificity D012720:Severity of Illness Index D020521:Stroke D015912:Thrombolytic Therapy D010959:Tissue Plasminogen Activator D014057:Tomography, X-Ray Computed
leukoaraiosis lacunes Stroke thrombolysis small vessel disease