Light- and temperature-responsive liposomes incorporating cinnamoyl Pluronic F127.
Light- and temperature-responsive liposomes were prepared by immobilizing cinnamoyl Pluronic F127 (CP F127) on the surface of egg phosphatidylcholine liposomes. CP F127 was prepared by a condensation reaction, and the molar ratio of cinnamoyl group to Pluronic F127 was calculated to be 1:1.4 on (1)H NMR spectrum. The cinnamoyl group of CP F127 was readily dimerized under the irradiation of a UV light (254 nm, 6 W). CP F127 decreased the absolute value of the zeta potential of liposome possibly because it can shift the hydrodynamic plane away from the liposome surface. The size of liposome decorated with CP F127, measured on a dynamic light scattering machine and observed on a TEM, was larger than that of bare liposome. The liposome bearing CP F127 seemed to fuse and aggregate each other. The liposome released calcein, a fluorescence dye, in response to a UV irradiation, possibly because the photo-dimerization of cinnamoyl group perturbs the liposomal membrane. Moreover, the liposome released the dye in response to a temperature change, possible due to the phase transition of Pluronic F127 layer on the liposomal surface or the hydrophobic interaction of the polymer with liposomal membrane.
['Wang|MinHui|M|', 'Kim|Jin-Chul|JC|']
D002626:Chemistry, Pharmaceutical D002934:Cinnamates D019281:Dimerization D016503:Drug Delivery Systems D005452:Fluoresceins D005456:Fluorescent Dyes D057927:Hydrophobic and Hydrophilic Interactions D007700:Kinetics D008081:Liposomes D046529:Microscopy, Electron, Transmission D010316:Particle Size D010713:Phosphatidylcholines D010777:Photochemistry D020442:Poloxamer D066244:Proton Magnetic Resonance Spectroscopy D012542:Scattering, Radiation D012995:Solubility D013050:Spectrometry, Fluorescence D013678:Technology, Pharmaceutical D013696:Temperature D014466:Ultraviolet Rays
Temperature-responsive Liposomes Cinnamoyl Pluronic F127 Release Light-responsive