Perfusion Cardiac Magnetic Resonance Imaging as a Rule-Out Test for Cardiac Allograft Vasculopathy.
Cardiac allograft vasculopathy (CAV) is a leading cause of mortality after heart transplantation. Noninvasive imaging techniques used in CAV evaluation have important limitations. In a cross-sectional study, we investigated perfusion cardiac magnetic resonance (CMR) imaging to determine an optimal myocardial perfusion reserve index (MPR) cutoff for detecting CAV using receiver operating characteristic curve analysis. We evaluated CMR performance using sensitivity, specificity and likelihood ratio analysis. We included 29 patients (mean 5 ± 4 years after transplant) scheduled for coronary angiography with intravascular ultrasound (IVUS) who completed CMR. CAV was defined as maximal intimal thickness (MIT) >0.5 mm by IVUS of the left anterior descending artery. CAV was evident in 19 patients (70%) on IVUS (mean MIT 0.82 ± 0.42 mm). MPR was significantly lower in patients with MIT ≥0.50 mm (1.35 ± 0.23 vs. 1.71 ± 0.45, p = 0.013). There was moderate inverse correlation between MPR and MIT (r = -0.36, p = 0.075). The optimal MPR cutoff ≤1.68 for predicting CAV showed sensitivity of 100%, specificity of 63%, a negative predictive value of 100%, a positive predictive value of 86% and a positive likelihood ratio of 2.7. An MPR ≤1.68 has high negative predictive value, suggesting its potential as a test to rule out CAV.
['Chih|S|S|', 'Ross|H J|HJ|', 'Alba|A C|AC|', 'Fan|C S|CS|', 'Manlhiot|C|C|', 'Crean|A M|AM|']
D000328:Adult D064591:Allografts D017023:Coronary Angiography D003324:Coronary Artery Disease D003430:Cross-Sectional Studies D005260:Female D005500:Follow-Up Studies D016027:Heart Transplantation D006801:Humans D018810:Magnetic Resonance Angiography D008297:Male D008875:Middle Aged D011379:Prognosis D011446:Prospective Studies D014652:Vascular Diseases
vasculopathy clinical research/practice diagnostic techniques and imaging: magnetic resonance imaging heart transplantation/cardiology