Maternal age at menarche and offspring body mass index in childhood.
BACKGROUND
Earlier age of menarche has been associated with an increased risk of chronic diseases during adulthood, but whether early menarche has intergenerational effect is not clear.


METHODS
In this population-based cross-sectional study, we recruited children from 26 primary schools using cluster random probability sampling in Shanghai, China, in 2014. We used multiple linear regression models to estimate the adjusted associations of maternal age of menarche (MAM) with offspring body mass index (BMI). We also used the mediation analysis to examine the contribution of maternal BMI and gestational diabetes to offspring BMI.


RESULTS
A total of 17,571 children aged 6-13 years were enrolled, of whom 16,373 had their weight and height measured. Earlier MAM was associated with higher child BMI in boys (- 0.05 z-score per year older MAM, 95% CI - 0.08 to - 0.02) and in girls (- 0.05 z-score per year older MAM, 95% CI - 0.07 to - 0.02). Maternal BMI positively mediated the association of MAM with offspring BMI in both sexes, with mediation effects of 37.7 and 19.4% for boys and girls, respectively.


CONCLUSION
Early maternal menarche was associated with greater offspring BMI. This study provides evidence for the intergenerational effect in the development of BMI in offspring.
['Wang|Hui|H|', 'Zhang|Yunting|Y|', 'Tian|Ying|Y|', 'Li|Fei|F|', 'Yan|Chonghui|C|', 'Wang|Hui|H|', 'Luo|Zhongchen|Z|', 'Jiang|Fan|F|', 'Zhang|Jun|J|']
D000293:Adolescent D000367:Age Factors D001827:Body Height D015992:Body Mass Index D001835:Body Weight D016009:Chi-Square Distribution D002648:Child D002681:China D003430:Cross-Sectional Studies D016640:Diabetes, Gestational D005260:Female D006801:Humans D016014:Linear Models D008297:Male D008423:Maternal Age D008572:Menarche D011247:Pregnancy D012737:Sex Factors
Body mass index Early menarche Intergenerational study