Overweight and obesity do not determine worst prognosis in endometrioid endometrial carcinoma.
PURPOSE
The aim of this study was to investigate the impact of body mass index (BMI) on disease-free survival (DFS) and overall survival (OS) in women diagnosed with EEC and treated at the Brazilian National Cancer Institute.


METHODS
The study comprised 849 women diagnosed with EEC who underwent surgical treatment between January, 2000 and December, 2011. The demographic and clinical characteristics of these patients were collected from medical records and their nutritional status was based on the BMI criteria. Univariate (OS and DFS) and multivariate analyses were performed using the Kaplan-Meier method and Cox proportional hazards models, respectively.


RESULTS
About 83.2% of patients were obese or overweight at time of diagnosis, with a mean BMI of 31.83. Patients were followed for an average of 34.97 months. There were 111 recurrences (13.1%) and 140 deaths (16.5%), with mean DFS of 51.90 months and mean OS of 52.25 months. There was no significant association between BMI and DFS or OS. In multivariate analysis we did not find an increased hazard of recurrence or death among overweight or obese patients.


CONCLUSION
Overweight and obesity had no impact on EEC prognosis on the assessed cohort. Further studies are warranted.
['Chaves|Gabriela Villaça|GV|', 'de Almeida Simao|Tatiana|T|', 'Pinto|Luis Felipe Ribeiro|LFR|', 'Moreira|Miguel Angelo Martins|MAM|', 'Bergmann|Anke|A|', 'Chaves|Claudia Bessa Pereira|CBP|http://orcid.org/0000-0003-1919-5672']
D000368:Aged D015992:Body Mass Index D018269:Carcinoma, Endometrioid D016889:Endometrial Neoplasms D005260:Female D006801:Humans D008875:Middle Aged D009765:Obesity D050177:Overweight D011379:Prognosis D012189:Retrospective Studies
Obesity Body mass index Survival Endometrial cancer