Effects of Dietary Exposure to Sulfamethazine on the Hematological Parameters and Hepatic Oxidative Stress Biomarkers in Nile Tilapia (Oreochromis niloticus).
Sulfamethazine (SMZ) is one of the most commonly used sulfonamide compounds in fish farming, and its physiological effects on fish are unknown. SMZ was administered to juvenile Nile tilapia (Oreochromis niloticus) at a dose level of 422 mg kg(-1) body weight, for a period of 11 days, via medicated feed. Fish were divided into two groups, the control group (CG) and the group fed with SMZ in feed. The administration of SMZ did not alter the erythrograms and leukograms of the Nile tilapia. The SMZ-fed group showed the same hepatic lipid peroxidation (LPO) concentration as the CG. Nonetheless, the oral administration of SMZ raised the hepatic catalase (CAT) and glutathione S-transferase (GST) activities, the increase probably being sufficient to prevent hepatic LPO production. The oral administration of SMZ affects the hepatic GST and CAT activities of Nile tilapia.
['Sampaio|Fernanda Garcia|FG|', 'Carra|Maria Lídia|ML|', 'Jonsson|Claudio Martin|CM|', 'Gonçalves|Vitoria Teodoro|VT|', "Dal'Bo|Genoefa|G|", 'Nunes|Kátia Santos Damacena|KS|', 'Valim|José Henrique|JH|', 'Dallago|Bruno Stéfano Lima|BS|', 'do Nascimento de Queiroz|Sonia Claudia|SC|', 'Reyes|Felix Guillermo Reyes|FG|']
D000284:Administration, Oral D000818:Animals D000890:Anti-Infective Agents D015415:Biomarkers D001772:Blood Cell Count D002374:Catalase D023681:Cichlids D004032:Diet D005982:Glutathione Transferase D015227:Lipid Peroxidation D008099:Liver D018384:Oxidative Stress D013418:Sulfamethazine
Sulfamethazine Antibiotics Antioxidant defense Toxicology