Unmet Needs in the Treatment of Gastroesophageal Reflux Disease.
Gastroesophageal reflux disease (GERD) is a highly prevalent gastrointestinal disorder. Proton pump inhibitors have profoundly revolutionized the treatment of GERD. However, several areas of unmet need persist despite marked improvements in the ther-apeutic management of GERD. These include the advanced grades of erosive esophagitis, nonerosive reflux disease, main-tenance treatment of erosive esophagitis, refractory GERD, postprandial heartburn, atypical and extraesophageal manifestations of GERD, Barrett's esophagus, chronic protein pump inhibitor treatment, and post-bariatric surgery GERD. Consequently, any fu-ture development of novel therapeutic modalities for GERD (medical, endoscopic, or surgical), would likely focus on the afore-mentioned areas of unmet need.
['Dickman|Ram|R|http://orcid.org/0000-0002-6477-2849', 'Maradey-Romero|Carla|C|http://orcid.org/0000-0003-3900-8598', 'Gingold-Belfer|Rachel|R|http://orcid.org/0000-0002-2831-4402', 'Fass|Ronnie|R|http://orcid.org/0000-0002-4807-3052']
Gastroesophageal Reflux Proton Pump Inhibitors Heartburn