Immune Responses to Pseudomonas aeruginosa Biofilm Infections.
Pseudomonas aeruginosa is a key pathogen of chronic infections in the lungs of cystic fibrosis patients and in patients suffering from chronic wounds of diverse etiology. In these infections the bacteria congregate in biofilms and cannot be eradicated by standard antibiotic treatment or host immune responses. The persistent biofilms induce a hyper inflammatory state that results in collateral damage of the adjacent host tissue. The host fails to eradicate the biofilm infection, resulting in hindered remodeling and healing. In the present review we describe our current understanding of innate and adaptive immune responses elicited by P. aeruginosa biofilms in cystic fibrosis lung infections and chronic wounds. This includes the mechanisms that are involved in the activation of the immune responses, as well as the effector functions, the antimicrobial components and the associated tissue destruction. The mechanisms by which the biofilms evade immune responses, and potential treatment targets of the immune response are also discussed.
['Moser|Claus|C|', 'Jensen|Peter Østrup|PØ|', 'Thomsen|Kim|K|', 'Kolpen|Mette|M|', 'Rybtke|Morten|M|', 'Lauland|Anne Sofie|AS|', 'Trøstrup|Hannah|H|', 'Tolker-Nielsen|Tim|T|']
D056704:Adaptive Immunity D000818:Animals D000900:Anti-Bacterial Agents D018441:Biofilms D054884:Host-Pathogen Interactions D006801:Humans D007113:Immunity, Innate D007116:Immunization, Passive D007155:Immunologic Factors D011552:Pseudomonas Infections D011550:Pseudomonas aeruginosa
Pseudomonas aeruginosa biofilm infections adaptive immune response innate immune response novel treatment possibilities