Maternal Resveratrol Treatment Re-Programs and Maternal High-Fat Diet-Induced Retroperitoneal Adiposity in Male Offspring.
Obesity during pregnancy increases the risk of cardiovascular problems, diabetes, asthma, and cognitive impairments, affecting the offspring. It is important to reduce the negative effects of obesity and high-fat (HF) diet during pregnancy. We employed a rat model of maternal HF diet to evaluate the possible de-programming effects of resveratrol in rodent male offspring with maternal HF diet/obesity. Male rat offspring were randomized into four groups: maternal control diet/postnatal control diet, maternal HF diet/postnatal control diet, maternal control diet plus maternal resveratrol treatment/postnatal control diet, and maternal HF diet plus maternal resveratrol treatment/postnatal control diet. Maternal HF diet during pregnancy plus lactation resulted in retroperitoneal adiposity in the male offspring. Maternal resveratrol treatment re-programmed maternal HF exposure-induced visceral adiposity. Offspring that received prenatal HF diet showed higher leptin/soluble leptin receptor (sOB-R) ratio than offspring that received prenatal control diet. Maternal resveratrol treatment ameliorated maternal HF exposure-induced increase in leptin/sOB-R ratio and altered the expression of genes for crucial fatty acid synthesis enzymes in the offspring. Thus, maternal resveratrol administration reduces retroperitoneal adiposity in rat offspring exposed to prenatal HF diet/obesity and could be used to ameliorate negative effects of maternal HF diet in the offspring.
['Tsai|Ti-An|TA|', 'Tsai|Chang-Ku|CK|', 'Huang|Li-Tung|LT|0000-0001-7403-288X', 'Sheen|Jiunn-Ming|JM|', 'Tiao|Mao-Meng|MM|0000-0002-0338-3495', 'Tain|You-Lin|YL|0000-0002-7059-6407', 'Chen|Chih-Cheng|CC|', 'Lin|I-Chun|IC|', 'Lai|Yun-Ju|YJ|', 'Tsai|Ching-Chou|CC|0000-0002-8302-1477', 'Lin|Yu-Ju|YJ|', 'Yu|Hong-Ren|HR|0000-0003-1242-8760']
D050154:Adiposity D000818:Animals D059305:Diet, High-Fat D005260:Female D008297:Male D039382:Maternal Nutritional Physiological Phenomena D009765:Obesity D011247:Pregnancy D011297:Prenatal Exposure Delayed Effects D011897:Random Allocation D051381:Rats D017207:Rats, Sprague-Dawley D000077185:Resveratrol
resveratrol prenatal leptin adipose tissue high-fat diet