Genomic Analysis Using Bayesian Methods under Different Genotyping Platforms in Korean Duroc Pigs.
Genomic evaluation has been widely applied to several species using commercial single nucleotide polymorphism (SNP) genotyping platforms. This study investigated the informative genomic regions and the efficiency of genomic prediction by using two Bayesian approaches (BayesB and BayesC) under two moderate-density SNP genotyping panels in Korean Duroc pigs. Growth and production records of 1026 individuals were genotyped using two medium-density, SNP genotyping platforms: Illumina60K and GeneSeek80K. These platforms consisted of 61,565 and 68,528 SNP markers, respectively. The deregressed estimated breeding values (DEBVs) derived from estimated breeding values (EBVs) and their reliabilities were taken as response variables. Two Bayesian approaches were implemented to perform the genome-wide association study (GWAS) and genomic prediction. Multiple significant regions for days to 90 kg (DAYS), lean muscle area (LMA), and lean percent (PCL) were detected. The most significant SNP marker, located near the MC4R gene, was detected using GeneSeek80K. Accuracy of genomic predictions was higher using the GeneSeek80K SNP panel for DAYS (Δ2%) and LMA (Δ2-3%) with two response variables, with no gains in accuracy by the Bayesian approaches in four growth and production-related traits. Genomic prediction is best derived from DEBVs including parental information as a response variable between two DEBVs regardless of the genotyping platform and the Bayesian method for genomic prediction accuracy in Korean Duroc pig breeding.
['Lee|Jungjae|J|0000-0002-6145-8862', 'Kim|Yongmin|Y|0000-0003-3163-8077', 'Cho|Eunseok|E|', 'Cho|Kyuho|K|', 'Sa|Soojin|S|', 'Kim|Youngsin|Y|', 'Choi|Jungwoo|J|', 'Kim|Jinsoo|J|', 'Hong|Junki|J|', 'Choi|Taejeong|T|']
Duroc single nucleotide polymorphism genome-wide association study genomic breeding value