Epidemiology of Respiratory Pathogens in Children with Lower Respiratory Tract Infections in Shanghai, China, from 2013 to 2015.
This study aimed to explore the epidemiology of pathogens in children who were hospitalized with lower respiratory tract infections (LRTIs) at the Children's Hospital of Fudan University, Shanghai, China. Children aged less than 18 years who were hospitalized with LRTIs were enrolled from January 2013 to December 2015. Respiratory specimens were collected for the detection of common respiratory viruses, atypical bacteria, and other bacteria using current laboratory diagnostic tests. The epidemiological characteristics of the respiratory pathogens were analyzed. Of the 10,123 specimens obtained from the patients, 5,966 (58.7%) were positive for at least 1 pathogen. Mycoplasma pneumoniae (M.pneumoniae) was the most commonly detected pathogen (15.7%), followed by respiratory syncytial virus (RSV) (13.9%). Co-infections were found in 11.4% of patients. Of these co-infections, viral-bacterial co-infections were the most common. The detection rates for the respiratory pathogens varied considerably by age. RSV was the most common pathogen in children aged less than 24 months. Clear seasonal peaks were observed for RSV, M. pneumoniae, parainfluenza virus, human metapneumovirus, Moraxella catarrhalis, and Haemophilus influenza infections. Our findings demonstrate specific epidemiological patterns in children with LRTIs in Shanghai, China.
['Liu|Pengcheng|P|', 'Xu|Menghua|M|', 'He|Leiyan|L|', 'Su|Liyun|L|', 'Wang|Aimin|A|', 'Fu|Pan|P|', 'Lu|Lijuan|L|', 'Wang|Chuanqing|C|', 'Xu|Jin|J|']
D000293:Adolescent D002648:Child D002675:Child, Preschool D002681:China D060085:Coinfection D005260:Female D006801:Humans D007223:Infant D007231:Infant, Newborn D008297:Male D009177:Mycoplasma pneumoniae D011019:Pneumonia, Mycoplasma D018357:Respiratory Syncytial Virus Infections D012136:Respiratory Syncytial Viruses D012141:Respiratory Tract Infections D012621:Seasons
epidemiology respiratory pathogen children lower respiratory tract infection aetiology