A Silver(I)-Estrogen Nanocluster: GSH Sensitivity and Targeting Suppression on HepG2 Cell.
A structure-determined silver nanocluster of [Ag10 (Eth)4 (CF3 COO)6 (CH3 OH)3 ]·3C-H3 OH (Eth = ethisterone) (1), is firstly demonstrated by self-assembly of silver salt and ethisterone. Due to the thiophilicity of silver(I) ions, complex 1 shows reactivity with glutathione (GSH) molecules in solution and induces the fluorescence quenching behavior. Thus, complex 1 can be used as a fluorescent sensor for GSH. In consideration of the higher level of GSH in cancerous cells, complex 1 presents significant tumor suppression reactivity toward the human hepatocellular carcinoma (HepG2) cells with IC50 value of 165 × 10-9 m. Especially, complex 1 displays 3.4-fold higher in vitro cytotoxicity to HepG2 cells than that of the normal CCC-HEL-1 cells, which makes complex 1 a potential targeting suppression agent for cancerous cells. The molecular design of complex 1 not only generates a new medicine-silver(I) cluster family, but also opens a new avenue to the targeting anticancer organosilver(I) materials.
['Shen|De-Feng|DF|', 'Wu|Shan-Shan|SS|', 'Wang|Rui-Rui|RR|', 'Zhang|Qiang|Q|', 'Ren|Zhong-Juan|ZJ|', 'Liu|Hong|H|', 'Guo|Hua-Dong|HD|', 'Gao|Guang-Gang|GG|']
D000970:Antineoplastic Agents D016923:Cell Death D048430:Cell Shape D004967:Estrogens D005003:Ethisterone D005978:Glutathione D056945:Hep G2 Cells D006801:Humans D053758:Nanoparticles D010316:Particle Size D012834:Silver D013050:Spectrometry, Fluorescence
targeting HepG2 cells silver nanoclusters ethisterone luminescence