Phytochemical analysis of crude extract of Delphinium brunonianum and its effect on hypertension and metabolic perturbations in fructose fed rats.
The present study aims at phytochemical profiling and valuating the effect of crude extract of Delphinium brunonianum on fructose mediated rise in blood pressure and metabolic abnormalities in rats. Therefore, rats were fed on fructose (10%w/v) for 6 weeks. Rats in treatment groups received amlodipine 250, 500 and 1000 mg/kg of DB-Cr separately in concurrent to fructose. Various parameters of metabolic perturbations were assessed at the end of study. Further, DB-Cr was analyzed using LC-MS technique. DB-Cr exerted remarkable antihypertensive effect whereas, sympathetic hyperactivity and hyperinsulinemia in these rats was significantly blunted, further, endothelium functionality was successfully restored. LC-MS analysis of DB-Cr revealed the presence of a variety of chemical constituents (41) including quinic acid, scopolin, gingerol, Robinetin 3-rutinoside, KAPA and maleic acid. In conclusion, D. brunonianum possess the potential to combat the fructose mediated hypertension and metabolic perturbations, which may partially be due to its chemical constituents.
['Asif|Hira|H|', 'Alamgeer|||', 'Bukhari|Ishfaq Ali|IA|', 'Vohra|Fahim|F|', 'Afzal|Sibtain|S|', 'Khan|Sher Wali|SW|', 'Niazi|Zahid Rasul|ZR|']
D000818:Animals D001794:Blood Pressure D031882:Delphinium D005632:Fructose D006973:Hypertension D064209:Phytochemicals D010936:Plant Extracts D051381:Rats
Delphinium brunonianum hypertension LC-MS analysis metabolic syndrome oxidative stress