Nonalcoholic fatty liver disease and liver transplantation - Where do we stand?
Nonalcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH) is a challenging and multisystem disease that has a high socioeconomic impact. NAFLD/NASH is a main cause of macrovesicular steatosis and has multiple impacts on liver transplantation (LT), on patients on the waiting list for transplant, on post-transplant setting as well as on organ donors. Current data indicate new trends in the area of chronic liver disease. Due to the increased incidence of metabolic syndrome (MetS) and its components, NASH cirrhosis and hepatocellular carcinoma caused by NASH will soon become a major indication for LT. Furthermore, due to an increasing incidence of MetS and, consequently, NAFLD, there will be more steatotic donor livers and less high quality organs available for LT, in addition to a lack of available liver allografts. Patients who have NASH and are candidates for LT have multiple comorbidities and are unique LT candidates. Finally, we discuss long-term grafts and patient survival after LT, the recurrence of NASH and NASH appearing de novo after transplantation. In addition, we suggest topics and areas that require more research for improving the health care of this increasing patient population.
['Mikolasevic|Ivana|I|', 'Filipec-Kanizaj|Tajana|T|', 'Mijic|Maja|M|', 'Jakopcic|Ivan|I|', 'Milic|Sandra|S|', 'Hrstic|Irena|I|', 'Sobocan|Nikola|N|', 'Stimac|Davor|D|', 'Burra|Patrizia|P|']
D015897:Comorbidity D006085:Graft Survival D006801:Humans D015994:Incidence D008099:Liver D008103:Liver Cirrhosis D008113:Liver Neoplasms D016031:Liver Transplantation D024821:Metabolic Syndrome D065626:Non-alcoholic Fatty Liver Disease D015995:Prevalence D012008:Recurrence D012307:Risk Factors D009927:Tissue and Organ Procurement D014850:Waiting Lists
Nonalcoholic fatty liver disease Liver transplantation Nonalcoholic steatohepatitis Chronic liver disease Outcome