Sex-dependent association of urate on the patterns of striatal dopamine depletion in Parkinson's disease.
BACKGROUND AND PURPOSE
The aim was to investigate the relationship between the serum urate (UA) levels and patterns of striatal dopamine depletion in patients with de novo Parkinson's disease (PD).


METHODS
In all, 167 de novo PD patients who underwent 18 F-fluorinated N-3-fluoropropyl-2-beta-carboxymethoxy-3-beta-(4-iodophenyl) nortropane positron emission tomography scans were enrolled. After quantifying dopamine transporter (DAT) availability in each striatal subregion, sex-dependent patterns of striatal dopamine depletion were analysed by measuring (i) dopamine depletion in the other striatal subregions and posterior putamen (intersubregional ratio, ISR) and (ii) the interhemispheric asymmetry of dopamine depletion in the posterior putamen (asymmetric ratio, AR).


RESULTS
The interaction analysis revealed a significant interaction effect of sex and serum UA levels on the ISR but not on the AR. The ISR was negatively correlated with the serum UA levels in all patients with PD (r = -0.156, P = 0.045), and this association was more prominent in male PD patients (r = -0.422, P < 0.001). However, no significant association between the AR and serum UA levels was found in any of the patients. In addition, serum UA levels were significantly associated with DAT availability in the posterior putamen on both the more affected side (r = 0.312, P = 0.005) and the less affected side (r = 0.312, P = 0.005) only in male PD patients.


CONCLUSIONS
The present study demonstrated the potentially close sex-specific relationship between the serum UA levels and the anterior-posterior gradient of DAT patterns, suggesting a sex-specific protective effect of UA on nigrostriatal dopaminergic neurons in de novo PD.
['Baik|K|K|0000-0001-7215-375X', 'Chung|S J|SJ|0000-0001-6086-3199', 'Yoo|H S|HS|0000-0001-7846-6271', 'Lee|Y H|YH|0000-0001-6813-9752', 'Jung|J H|JH|0000-0002-1431-2975', 'Sohn|Y H|YH|', 'Lee|P H|PH|']
D000368:Aged D003342:Corpus Striatum D004298:Dopamine D050483:Dopamine Plasma Membrane Transport Proteins D005260:Female D006801:Humans D008297:Male D010300:Parkinson Disease D049268:Positron-Emission Tomography D012727:Sex Characteristics D014527:Uric Acid
urate dopamine transporter sex Parkinson’s disease