Upregulated miR-410 is linked to poor prognosis in colorectal cancer.
BACKGROUND
Although miR-410 acts as a cancer inducer in colorectal cancer, there is limited data on the clinical implications of miR-410 expression levels in patients. We hypothesized a link between miR-410 expression and its potential clinical values in patients with colorectal cancer.


MATERIAL AND METHODS
120 colorectal cancer tissue specimens and 120 adjacent non-tumour tissues were obtained. Quantification of miR-410 expression levels was determined by, quantitative RT-PCR. Expression was analysed by clinical features.


RESULTS
miR-410 was up-regulated in malignant tissues compared with corresponding normal tissues (P < 0.01), with TNM stage and lymph node metastasis (P = 0.03, P = 0.004, respectively), and with worse overall survival (P = 0.002). Multivariate survival analysis identified it as an independent risk factor for outcome (P = 0.021, HR = 2.19; 95% CI = 1.12-4.25).


CONCLUSION
Compared to normal non-cancerous tissues, miR-410 was overexpressed in tumour tissues and is independently associated with the unfavourable outcome. Levels of MiR-410 might a useful laboratory tool in managing and predicting the prognosis of colorectal cancer.
['Abedi|P|P|', 'Bayat|A|A|https://orcid.org/0000-0001-9152-3680', 'Ghasemzadeh|S|S|https://orcid.org/0000-0002-1196-3027', 'Raad|M|M|https://orcid.org/0000-0001-6530-3326', 'Pashaiefar|H|H|', 'Ahmadvand|M|M|']
D014408:Biomarkers, Tumor D015179:Colorectal Neoplasms D005260:Female D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008207:Lymphatic Metastasis D008297:Male D035683:MicroRNAs D008875:Middle Aged D015999:Multivariate Analysis D011379:Prognosis D060888:Real-Time Polymerase Chain Reaction D012307:Risk Factors D015854:Up-Regulation
miR-410 prognosis Colorectal cancer overall survival RT-qPCR clinicopathological characteristics