Functional Changes in the Language Network in Response to Increased Amyloid β Deposition in Cognitively Intact Older Adults.
Word finding symptoms are frequent early in the course of Alzheimer's disease and relate principally to functional changes in left posterior temporal cortex. In cognitively intact older adults, we examined whether amyloid load affects the network for language and associative-semantic processing. Fifty-six community-recruited subjects (52-74 years), stratified for apolipoprotein E and brain-derived neurotrophic factor genotype, received a neurolinguistic assessment, (18)F-flutemetamol positron emission tomography, and a functional MRI of the associative-semantic system. The primary measure of amyloid load was the cerebral-to-cerebellar gray matter standardized uptake value ratio in a composite cortical volume of interest (SUVR(comp)). The primary outcome analysis consisted of a whole-brain voxelwise linear regression between SUVR(comp) and fMRI response during associative-semantic versus visuoperceptual processing. Higher activity in one region, the posterior left middle temporal gyrus, correlated positively with increased amyloid load. The correlation remained significant when only the word conditions were contrasted but not for pictures. According to a stepwise linear regression analysis, offline naming reaction times correlated positively with SUVR(comp). A binary classification into amyloid-positive and amyloid-negative cases confirmed our findings. The left posterior temporal activity increase may reflect higher demands for semantic control in the presence of a higher amyloid burden.
['Adamczuk|Katarzyna|K|', 'De Weer|An-Sofie|AS|', 'Nelissen|Natalie|N|', 'Dupont|Patrick|P|', 'Sunaert|Stefan|S|', 'Bettens|Karolien|K|', 'Sleegers|Kristel|K|', 'Van Broeckhoven|Christine|C|', 'Van Laere|Koen|K|', 'Vandenberghe|Rik|R|']
D000544:Alzheimer Disease D000682:Amyloid D016229:Amyloid beta-Peptides D001921:Brain D060825:Cognitive Dysfunction D006801:Humans D007802:Language D008279:Magnetic Resonance Imaging D049268:Positron-Emission Tomography D012660:Semantics
Alzheimer fMRI semantic 18F-flutemetamol amyloid PET