In vitro fertilization in women under 35: counseling should differ by age.
PURPOSE
The aim of this study is to evaluate the outcomes of in vitro fertilization (IVF), including cumulative live birth rate, among women <25 years, 25 to <30 years, and 30 to <35 years.


METHODS
A retrospective cohort study of all women 18 to <35 years of age at their first fresh-embryo, non-donor IVF cycle from January 1995 through December 2012 at a single center was conducted. A competing-risk regression model was used to estimate the cumulative probability and 95 % confidence interval (CI) of the first live birth in up to 6 cycles during the study period with IVF cycle number as the time metric.


RESULTS
Among 7243 women who underwent 16,792 cycles, there were 163 (2.3 %) women <25 years, 1691 (23.3 %) women 25 to <30 years, and 5389 (74.4 %) women 30 to <35 years. Women <25 years had the lowest cumulative live birth rate after each cycle, followed by women 30 to <35 years. In both groups, the cumulative live birth rate after 6 cycles was significantly lower than that of women 25 to <30 years; these rates were 58 % (95 % CI 0.51-0.66) among women <25 years, 69 % (95 % CI 0.67-0.71) among women 25 to <30 years, and 64 % (95 % CI 0.63-0.65) among women 30 to <35 years.


CONCLUSIONS
Our findings are consistent with other reports of less favorable IVF treatment outcomes in women <25 years of age following their first IVF cycle. This indicates that there are underlying factors in couples with a female <25 years of age that should lead to different treatment counseling when they attempt IVF.
['Humm|K C|KC|', 'Dodge|L E|LE|', 'Wu|L H|LH|', 'Penzias|A S|AS|', 'Malizia|B A|BA|', 'Sakkas|D|D|', 'Hacker|M R|MR|']
D000328:Adult D001723:Birth Rate D015331:Cohort Studies D003376:Counseling D005260:Female D005307:Fertilization in Vitro D006801:Humans D007247:Infertility, Female D007248:Infertility, Male D050498:Live Birth D008297:Male D008423:Maternal Age D011247:Pregnancy D018873:Pregnancy Rate D012189:Retrospective Studies D020554:Sperm Injections, Intracytoplasmic D016896:Treatment Outcome
In vitro fertilization IVF Cumulative live birth rate Young women