The Interplay between ESCRT and Viral Factors in the Enveloped Virus Life Cycle.
Viruses are obligate parasites that rely on host cellular factors to replicate and spread. The endosomal sorting complexes required for transport (ESCRT) system, which is classically associated with sorting and downgrading surface proteins, is one of the host machineries hijacked by viruses across diverse families. Knowledge gained from research into ESCRT and viruses has, in turn, greatly advanced our understanding of many other cellular functions in which the ESCRT pathway is involved, e.g., cytokinesis. This review highlights the interplay between the ESCRT pathway and the viral factors of enveloped viruses with a special emphasis on retroviruses.
['Meng|Bo|B|', 'Lever|Andrew M L|AML|']
D000818:Animals D056827:Endosomal Sorting Complexes Required for Transport D006801:Humans D021381:Protein Transport D012190:Retroviridae D012192:Retroviridae Infections D014764:Viral Proteins D014779:Virus Replication
ESCRT enveloped virus NEDD4 budding late domain retrovirus