Peripheral blood CD34+ cells as a novel and noninvasive early marker of first trimester miscarriage: results from a case-control analysis.
PURPOSE
To evaluate the levels of peripheral blood CD34+ cells in women who subsequently had a spontaneous miscarriage (SM).


MATERIALS AND METHODS
We enrolled 11 women who had SM, matching them for age, BMI and gestational age with 33 healthy pregnancies (controls). From a blood sample at 9th-11th weeks of pregnancy, we evaluated PAPP-A, free β-hCG, T (suppressor and helper), NK, B, CD34+ cells.


RESULTS
In peripheral blood of women who had SM, PAPP-A and CD34+ cells were significantly lower (p < 0.001) compared to control group.


CONCLUSIONS
CD34+ cell low level in peripheral blood is associated with increased risk of SM.
['Giordano|Domenico|D|', 'Loddo|Saverio|S|', 'Laganà|Antonio Simone|AS|http://orcid.org/0000-0003-1543-2802', 'Coppolino|Giuseppe|G|', 'Zoccali|Giuseppe|G|', 'Di Benedetto|Antonino|A|', 'Santamaria|Angelo|A|', 'Buemi|Michele|M|', "D'Anna|Rosario|R|"]
D000022:Abortion, Spontaneous D000328:Adult D018952:Antigens, CD34 D015415:Biomarkers D016022:Case-Control Studies D005260:Female D006801:Humans D011247:Pregnancy D011261:Pregnancy Trimester, First D011266:Pregnancy-Associated Plasma Protein-A D055815:Young Adult
peripheral blood CD34 first trimester miscarriage Hematopoietic stem cells