Detection of Non-Small Lung Cell Carcinoma-Associated Genetic Alterations Using a NanoString Gene Expression Platform Approach.
In non-small cell lung cancer (NSCLC), mutation detection and fusion gene status are treatment predictive and, hence, key factors in clinical management. Lately, alternate splicing variants of MET have gained focus as NSCLC tumors harboring a MET exon 14 skipping event have proven sensitive toward targeted therapy. Reliable methods for detection of genetic alterations in NSCLC have proven to be of increased importance. This chapter provides with hands-on experience of the NanoString gene expression platform for detection of genetic alterations in NSCLC.
['Staaf|Johan|J|', 'Jönsson|Mats|M|', 'Karlsson|Anna F|AF|']
D017398:Alternative Splicing D002289:Carcinoma, Non-Small-Cell Lung D005091:Exons D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008175:Lung Neoplasms D019859:Proto-Oncogene Proteins c-met
NanoString Gene expression Fusion gene Non-small cell lung carcinoma