A novel herbometallic nanodrug has the potential for antibacterial and anticancer activity through oxidative damage.
Aim: Preparation of a herbometallic nano-drug, Rasa Manikya nanoparticle (RMNP) and investigation of its antimicrobial, and anticancer activity. Materials & methods: Physicochemical characterizations of RMNP were performed using different analytical methods. The antimicrobial and anticancer potential of RMNPs were assessed by an in vitro cellular assay. Bacterial cell wall lysis was observed by field emission scanning electron microscopy and mitochondrial metabolism alteration factor was measured via standard method. Results: Physicochemical analysis confirmed that RMNP was rich in mineral constituents. Synergistic effect of RMNPs enhanced lysis of bacterial peptidoglycan layers and impaired cellular redox balance, GSH/NADPH level followed by induction of cell apoptosis. Conclusion: The present study confirms that RMNP can be used as a dual therapeutic option for combating drug-resistant microbial strains and breast cancer.
['Ruidas|Bhuban|B|', 'Som Chaudhury|Sutapa|S|', 'Pal|Kunal|K|', 'Sarkar|Prashanta Kumar|PK|', 'Das Mukhopadhyay|Chitrangada|C|']
D000900:Anti-Bacterial Agents D000970:Antineoplastic Agents D017209:Apoptosis D001152:Arsenicals D002460:Cell Line D045744:Cell Line, Tumor D002470:Cell Survival D004754:Enterobacter D004926:Escherichia coli D006801:Humans D008515:Medicine, Ayurvedic D053768:Metal Nanoparticles D008826:Microbial Sensitivity Tests D010084:Oxidation-Reduction D018384:Oxidative Stress D028321:Plant Preparations D013211:Staphylococcus aureus D013440:Sulfides
peptidoglycan layer cellular redox balance apoptosis antimicrobial activity herbometallic drug