Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice.
Huntington Disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the exon1 of huntingtin gene (HTT). The mutant HTT affects the transcriptional profile of neurons by disrupting the activities of transcriptional machinery and alters expression of many genes. In this study, we identified dysregulated non-coding RNAs (ncRNAs) in medium spiny neurons of 4-week-old HD model mouse. Also, we observed the intracellular localizations of Abhd11os and Neat1 ncRNAs by ViewRNA in situ hybridization, which could provide more precise detection, suggesting that it is a useful method to investigate the expression changes of genes with low expression levels.
['Park|Hongsun|H|', 'Miyazaki|Haruko|H|', 'Yamanaka|Tomoyuki|T|', 'Nukina|Nobuyuki|N|']
D000818:Animals D001921:Brain D003342:Corpus Striatum D004195:Disease Models, Animal D051937:Dopamine and cAMP-Regulated Phosphoprotein 32 D015870:Gene Expression D006801:Humans D006816:Huntington Disease D017403:In Situ Hybridization D051379:Mice D008822:Mice, Transgenic D009474:Neurons D062085:RNA, Long Noncoding D057057:Serine Proteases D059467:Transcriptome
Non-coding RNA Neat1 Abhd11os Huntington disease ViewRNA in situ hybridization Gene expression Microarray