Mebeverine-loaded electrospun nanofibers: physicochemical characterization and dissolution studies.
Both fast dissolving and sustained release drug delivery systems (DDSs) comprising mebeverine hydrochloride (MB-HCl) embedded in either povidone (PVP) K60 or Eudragit(®) L 100-55 nanofibers have been prepared by electrospinning. The fibers are found to have cylindrical morphologies with smooth surfaces, except at high drug loadings that appear to induce surface roughness (PVP) or fragmentation (Eudragit). There is a general increase in fiber diameter with drug loading. Differential scanning calorimetry and X-ray diffraction demonstrate that the drug exists in an amorphous state in the fibers. Infrared spectroscopy data indicate that the drug has good compatibility with the polymer, whereas nuclear magnetic resonance spectroscopy and high-performance liquid chromatography analyses confirmed that the MB-HCl was not degraded during the spinning process. In vitro dissolution tests of the PVP fiber mats show them to dissolve within 10 s, an improved dissolution profile over the pure drug. The Eudragit fibers show pH-dependent drug release profiles, with only very limited release at pH 2.0 but sustained release over approximately 8 h at pH 6.8. The Eudragit nanofibers have the potential to be developed as oral DDSs for localized drug release in the intestinal tract, whereas the PVP materials may find the application as buccal delivery systems or suppositories.
['Illangakoon|Upulitha Eranka|UE|', 'Nazir|Tahir|T|', 'Williams|Gareth R|GR|', 'Chatterton|Nicholas P|NP|']
D003692:Delayed-Action Preparations D016503:Drug Delivery Systems D006863:Hydrogen-Ion Concentration D057139:Nanofibers D010627:Phenethylamines D011108:Polymers D011109:Polymethacrylic Acids D011205:Povidone D012995:Solubility
electrospun nanofibers mebeverine hydrochloride povidone Eudragit buccal delivery nanotechnology oral drug delivery site-specific delivery solid dosage form solid solutions