An Anisotropic Hydrogel Based on Mussel-Inspired Conductive Ferrofluid Composed of Electromagnetic Nanohybrids.
Anisotropic hydrogels with a hierarchical structure can mimic biological tissues, such as neurons or muscles that show directional functions, which are important factors for signal transduction and cell guidance. Here, we report a mussel-inspired approach to fabricate an anisotropic hydrogel based on a conductive ferrofluid. First, polydopamine (PDA) was used to mediate the formation of PDA-chelated carbon nanotube-Fe3O4 (PFeCNT) nanohybrids and also used as a dispersion medium to stabilize the nanohybrids to form a conductive ferrofluid. The ferrofluid can respond to an orientated magnetic field and be programed to form aligned structures, which were then frozen in a hydrogel network formed via in situ free-radical polymerization and gelation. The resulted hydrogel shows directional conductive and mechanical properties, mimicking an oriented biological tissue. Under external electrical stimulation, the orientated PFeCNT nanohybrids can be sensed by the myoblasts cultured on the hydrogel, resulting in the oriented growth of cells. In summary, the mussel-inspired anisotropic hydrogel with its aligned structural complexity and anisotropic properties together with the cell affinity and tissue adhesiveness is a potent multifunctional biomaterial for mimicking oriented tissues to guide cell proliferation and tissue regeneration.
['Liu|Kezhi|K|', 'Han|Lu|L|', 'Tang|Pengfei|P|', 'Yang|Kaiming|K|', 'Gan|Donglin|D|', 'Wang|Xiao|X|', 'Wang|Kefeng|K|0000-0002-2504-4662', 'Ren|Fuzeng|F|0000-0002-9310-2174', 'Fang|Liming|L|', 'Xu|Yonggang|Y|', 'Lu|Zhifeng|Z|', 'Lu|Xiong|X|0000-0001-6367-430X']
D000818:Animals D016880:Anisotropy D049872:Bivalvia D002460:Cell Line D004553:Electric Conductivity D052203:Ferrosoferric Oxide D020100:Hydrogels D060526:Magnetic Fields D051379:Mice D032446:Myoblasts D053761:Nanocomposites
Anisotropic hydrogels ferrofluid carbon nanotube conductive hydrogels magnetic nanoparticles mussel-inspired adhesive hydrogels