Spectanoids A-H: Eight undescribed sesterterpenoids from Aspergillus spectabilis.
Ten sesterterpenoids, including eight undescribed ones named spectanoids A-H and two known analogs, were obtained from Aspergillus spectabilis. Their structures, including absolute configurations, were determined based on HRESIMS, NMR, ECD calculations and single-crystal X-ray diffraction analyses. Spectanoids A-G are tricyclic sesterterpenoids with an unusual 5/12/5 ring system, while spectanoid H possesses a 5/8/6/5 ring system. All of these compounds were evaluated for their cytotoxic activities against three human cancer cells, and spectanoid A, spectanoid C and spectanoid F exhibited moderate cytotoxic activities with IC50 values ranging from 12.1 to 26.1 μM.
['Wei|Mengsha|M|', 'Zhou|Peng|P|', 'Huang|Liping|L|', 'Yin|Jie|J|', 'Li|Qin|Q|', 'Dai|Chong|C|', 'Wang|Jianping|J|', 'Gu|Lianghu|L|', 'Tong|Qingyi|Q|', 'Zhu|Hucheng|H|', 'Zhang|Yonghui|Y|']
D001230:Aspergillus D018360:Crystallography, X-Ray D009682:Magnetic Resonance Spectroscopy D015394:Molecular Structure
Sesterterpenoids Aspergillus spectabilis Cytotoxic activities Aspergillaceae