Tumor-derived exosomal microRNAs and proteins as modulators of macrophage function.
Tumor cells are able to modify their surrounding microenvironment by transmitting bioactive molecules via exosomes. In exosomes, proteins and nucleic acids that can be taken up by surrounding cells have been identified and modulate their functions. Tumor microenvironment consists of different cells such as macrophages. Tumors-associated macrophages (TAMs) express M2 phenotype and affect many processes including tumor initiation, angiogenesis, and metastasis. It has been demonstrated that a high number of TAMs is associated with poor prognosis of cancers. The contents of tumor-derived exosomes such as microRNAs and proteins induce macrophages to M2-like polarization to support tumor growth. Herein, we review the most recent studies on the effect of tumor-derived exosomes on macrophage polarization and function in different types of cancers.
['Moradi-Chaleshtori|Maryam|M|', 'Hashemi|Seyed Mahmoud|SM|', 'Soudi|Sara|S|', 'Bandehpour|Mojgan|M|', 'Mohammadi-Yeganeh|Samira|S|0000-0003-0430-6325']
D049109:Cell Proliferation D055354:Exosomes D015972:Gene Expression Regulation, Neoplastic D006801:Humans D008262:Macrophage Activation D008264:Macrophages D035683:MicroRNAs D009369:Neoplasms D059016:Tumor Microenvironment
tumor-derived exosomes tumor microenvironment tumors-associated macrophages miRNAs