Role of aromatic amino acids in amyloid self-assembly.
Amyloids are proteins of a cross-β structure found as deposits in several diseases and also in normal tissues (nails, spider net, silk). Aromatic amino acids are frequently found in amyloid deposits. Although they are not indispensable, aromatic amino acids, phenylalanine, tyrosine and tryptophan, enhance significantly the kinetics of formation and thermodynamic stability, while tape or ribbon-like morphology is represented in systems with experimentally detected π-π interactions between aromatic rings. Analysis of geometries and energies of the amyloid PDB structures indicate the prevalence of aromatic-nonaromatic interactions and confirm that aromatic-aromatic interactions are not crucial for the amyloid formation.
['Stanković|Ivana M|IM|', 'Niu|Shuqiang|S|', 'Hall|Michael B|MB|', 'Zarić|Snežana D|SD|']
D024322:Amino Acids, Aromatic D000682:Amyloid D058227:Amyloidogenic Proteins D000818:Animals D006801:Humans D057927:Hydrophobic and Hydrophilic Interactions D007700:Kinetics D008958:Models, Molecular D008968:Molecular Conformation D066329:Protein Aggregates D066263:Protein Aggregation, Pathological D011789:Quantum Theory D013816:Thermodynamics
Aromatic amino acids Amyloids Self-assembly