Reasons and predictors for antiretroviral therapy change among HIV-infected adults at South West Ethiopia.
OBJECTIVE
This retrospective cohort study is aimed to assess reasons and predictors of regimen change from initial highly active antiretroviral therapy among 1533 Human Immunodeficiency virus-infected adult patients at the Jimma University Tertiary Hospital.


RESULTS
One in two (47.7%) adults changed their antiretroviral therapy regimen. Patients who were above the primary level of education [Hazard ratio (HR) 1.241 (95% CI 1.070-1.440)] and with human immunodeficiency virus/tuberculosis co-infection [HR 1.405 (95% CI 1.156-1.708)] had the higher risk of regimen change than their comparator. Individuals on Efavirenz [HR 0.675 (95% CI 0.553-0.825)] and non-stavudine [HR 0.494 (95% CI 0.406-0.601)] based regimens had lower risk of regimen change.
['Mekonnen|Endalkachew|E|', 'Workicho|Abdulhalik|A|', 'Hussein|Nezif|N|', 'Feyera|Teka|T|']
D000328:Adult D019380:Anti-HIV Agents D023241:Antiretroviral Therapy, Highly Active D004522:Educational Status D005002:Ethiopia D005260:Female D015658:HIV Infections D006785:Hospitals, University D006801:Humans D008297:Male D012189:Retrospective Studies D012307:Risk Factors D062606:Tertiary Care Centers D014376:Tuberculosis
Ethiopia Regimen change Initial highly active antiretroviral therapy Risk factors