Can we consider silymarin as a treatment option for vitiligo? A double-blind controlled randomized clinical trial of phototherapy plus oral Silybum marianum product versus phototherapy alone.
Introduction: Vitiligo is a chronic skin disorder caused by destruction of the skin melanocytes, which presents as a depigmented area in the skin. This study examined the effect of Phototherapy plus oral Silybummarianum on the treatment of skin lesions of Vitiligo.Materials and methods: In this randomized controlled clinical trial, 34 patients with vitiligo who were referred to Dermatology Clinic of Shahid Faghihi Hospital, Shiraz, Iran, were randomly divided into two groups. The first group was treated with phototherapy plus Narrowband UVB plus oral silymarin and the other group was treated with phototherapy with placebo. The patients in both groups were evaluated with vitiligo area severity index (VASI) at the beginning and end of the study. SPSS software version 23 was used for statistical analyses.Results: The mean of the VASI score showed a statistically significant decrease in both groups at the end of the study (p < .05), but the decrease in the VASI score in patients who received Silybum marianum was more in comparison with the other group.Conclusion: This study showed that probably Silybum marianum is a good choice for patients with vitiligo; however, further studies are recommended to be conducted to confirm our result.
['Jowkar|Farideh|F|http://orcid.org/0000-0002-0293-3117', 'Godarzi|Hamid|H|', 'Parvizi|Mohammad Mahdi|MM|http://orcid.org/0000-0003-1856-945X']
D000284:Administration, Oral D000293:Adolescent D000328:Adult D000368:Aged D000975:Antioxidants D004311:Double-Blind Method D005260:Female D006801:Humans D007492:Iran D008297:Male D008875:Middle Aged D010789:Phototherapy D012720:Severity of Illness Index D012838:Silymarin D012867:Skin D014466:Ultraviolet Rays D014820:Vitiligo D055815:Young Adult
silymarin Vitiligo phototherapy Silybum marianum