Phytochemical and pharmacological investigation of Spiraea chamaedryfolia: a contribution to the chemotaxonomy of Spiraea genus.
OBJECTIVE
Diterpene alkaloids are secondary plant metabolites and chemotaxonomical markers with a strong biological activity. These compounds are characteristic for the Ranunculaceae family, while their occurrence in other taxa is rare. Several species of the Spiraea genus (Rosaceae) are examples of this rarity. Screening Spiraea species for alkaloid content is a chemotaxonomical approach to clarify the classification and phylogeny of the genus. Novel pharmacological findings make further investigations of Spiraea diterpene alkaloids promising.


RESULTS
Seven Spiraea species were screened for diterpene alkaloids. Phytochemical and pharmacological investigations were performed on Spiraea chamaedryfolia, the species found to contain diterpene alkaloids. Its alkaloid-rich fractions were found to exert a remarkable xanthine-oxidase inhibitory activity and a moderate antibacterial activity. The alkaloid distribution within the root was clarified by microscopic techniques.
['Kiss|Tivadar|T|', 'Cank|Kristóf Bence|KB|', 'Orbán-Gyapai|Orsolya|O|', 'Liktor-Busa|Erika|E|', 'Zomborszki|Zoltán Péter|ZP|', 'Rutkovska|Santa|S|', 'Pučka|Irēna|I|', 'Németh|Anikó|A|', 'Csupor|Dezső|D|http://orcid.org/0000-0002-4088-3333']
D000470:Alkaloids D000900:Anti-Bacterial Agents D005591:Chemical Fractionation D052978:Disk Diffusion Antimicrobial Tests D004224:Diterpenes D004791:Enzyme Inhibitors D064209:Phytochemicals D018517:Plant Roots D013045:Species Specificity D031992:Spiraea D014969:Xanthine Oxidase
Spiraea Chemotaxonomy Alkaloids Xanthine-oxidase Antibacterial Phytochemistry