Bahamaolide A from the marine-derived Streptomyces sp. CNQ343 inhibits isocitrate lyase in Candida albicans.
Bahamaolide A, a new macrocyclic lactone isolated from the culture of marine actinomycete Streptomyces sp. CNQ343, was evaluated for its inhibitory activity toward isocitrate lyase (ICL) from Candida albicans. These studies led to the identification of bahamaolide A as a potent ICL inhibitor with IC50 value of 11.82 μM. The growth phenotype of ICL deletion mutants and quantitative RT-PCR analyses indicated that this compound inhibits the ICL mRNA expression in C. albicans under C2-carbon-utilizing conditions. The present data highlight the potential for bahamaolide A treatment of C. albicans infections via inhibition of ICL activity.
['Lee|So-Hyoung|SH|', 'Moon|Kyuho|K|', 'Kim|Heegyu|H|', 'Shin|Jongheon|J|', 'Oh|Dong-Chan|DC|', 'Oh|Ki-Bong|KB|']
D000935:Antifungal Agents D002176:Candida albicans D004305:Dose-Response Relationship, Drug D004791:Enzyme Inhibitors D007522:Isocitrate Lyase D007783:Lactones D018942:Macrolides D008826:Microbial Sensitivity Tests D008968:Molecular Conformation D011090:Polyenes D013302:Streptomyces D013329:Structure-Activity Relationship
Bahamaolide A Streptomyces sp. Isocitrate lyase Candida albicans Marine actinomycete