Involvement of Hippocampal D1-Like Dopamine Receptors in the Inhibitory Effect of Cannabidiol on Acquisition and Expression of Methamphetamine-Induced Conditioned Place Preference.
Cannabidiol (CBD) is a non-psychotomimetic compound with strong potential to decrease the psychostimulant's rewarding effect with unclear receptors. Furthermore, as a part of the reward circuit, the hippocampus plays a crucial role in regulating the reward properties of drugs as determined by conditioned place preference (CPP). In the current research, CPP was used to evaluate the role of intra-CA1 microinjection of D1-like dopamine receptor antagonists in CBD's inhibitory effect on the acquisition and expression phases of methamphetamine (METH). Animals were treated by METH (1 mg/kg; sc) in a five-day schedule to induce CPP. To find out the impact of D1-like dopamine receptor antagonist, SCH23390, in the CA1 on the inhibitory influence of CBD on the acquisition of METH, the rats received intra-CA1 administration of SCH23390 (0.25, 1, and 4 µg/0.5 µl) following ICV treatment of CBD (10 µg/5 µl) over conditioning phase of METH. Furthermore, animals were given SCH23390 in the CA1 ensuing ICV microinjection of CBD (50 µg/5 µl) in the expression phase of METH to rule out the influence of SCH23390 on the suppressive effect of CBD on the expression of METH CPP. Intra-CA1 microinjection of SCH23390 abolished CBD's suppressive impact on both METH-induced CPP phases without any side effect on the locomotion. The current research disclosed that CBD inhibited the rewarding characteristic of METH via D1-like dopamine receptors in the CA1 region of the hippocampus.
['Nouri|Kiana|K|', 'Anooshe|Mahsa|M|', 'Karimi-Haghighi|Saeideh|S|', 'Mousavi|Zahra|Z|', 'Haghparast|Abbas|A|http://orcid.org/0000-0003-1084-180X']
D000818:Animals D001552:Benzazepines D056547:CA1 Region, Hippocampal D002185:Cannabidiol D002491:Central Nervous System Agents D003213:Conditioning, Psychological D018492:Dopamine Antagonists D008297:Male D008694:Methamphetamine D017208:Rats, Wistar D017447:Receptors, Dopamine D1
D1-like dopamine receptor Cannabidiol Conditioned place preference Reward Methamphetamine Rat Dopamine system Hippocampal CA1 region