Light-triggered theranostic liposomes for tumor diagnosis and combined photodynamic and hypoxia-activated prodrug therapy.
Hypoxia tumor microenvironment is a major challenge for photodynamical therapy (PDT), and hypoxia-activated chemotherapy combined PDT could be promising for enhanced anticancer therapy. In this study, we report an innovative 2-nitroimidazole derivative conjugated polyethylene glycol (PEG) amphoteric polymer theranostic liposome encapsulated a photosensitizer Chlorin e6 (Ce6), hypoxia-activated prodrug Tirapazamine (TPZ) and gene probe for synergistic photodynamic-chemotherapy. Ce6-mediated PDT upon irradiation with a laser induces hypoxia, which leads to the disassembly of the liposome and activates the antitumor activity of TPZ for improved cancer cell-killing. The released co-delivered gene probe could effectively detect the oncogenic intracellular biomarker for diagnosis. Both in vitro and in vivo studies demonstrated the greatly improved anti-cancer activity compared to conventional PDT. This work contributes to the design of hypoxia-responsive multifunctional liposome for tumor diagnosis and hypoxia-activated chemotherapy combined PDT for synergetic therapy, which holds great promise for future cancer therapy.
['Zhang|Kai|K|', 'Zhang|Yuedong|Y|', 'Meng|Xiangdan|X|', 'Lu|Huiting|H|', 'Chang|Huan|H|', 'Dong|Haifeng|H|', 'Zhang|Xueji|X|']
D000818:Animals D000970:Antineoplastic Agents D002735:Chlorophyllides D003692:Delayed-Action Preparations D006801:Humans D008027:Light D008081:Liposomes D061986:MCF-7 Cells D051379:Mice D009369:Neoplasms D009593:Nitroimidazoles D061848:Optical Imaging D017319:Photosensitizing Agents D011092:Polyethylene Glycols D011166:Porphyrins D000068936:Theranostic Nanomedicine D000077704:Tirapazamine D000072258:Tumor Hypoxia
Liposomes Photodynamic therapy Drug delivery Hypoxia activated prodrug Tumor hypoxia