Extracellular Matrix for Myocardial Repair.
Multiple strategies have been investigated to restore functional myocardium following injury or disease including the local administration of cytokines or chemokines, stem/progenitor cell therapy, mechanical circulatory support, pharmacologic use, and the use of inductive biomaterials. The use of xenogeneic biologic scaffolds composed of extracellular matrix (ECM) has been shown to facilitate functional restoration of several tissues and organs including the esophagus, skeletal muscle, skin, and myocardium, among others. The present chapter describes the current understanding of specific components of biologic scaffolds composed of ECM, the mechanisms by which ECM bioscaffolds promote constructive cardiac remodeling after injury, determinants of remodeling outcome, and the versatility of ECM as a potential cardiac therapeutic.
['Dziki|Jenna L|JL|', 'Badylak|Stephen F|SF|']
D000818:Animals D064752:Atrial Remodeling D001705:Bioprosthesis D006348:Cardiac Surgical Procedures D005109:Extracellular Matrix D006321:Heart D006350:Heart Valve Prosthesis D006801:Humans D008264:Macrophages D009206:Myocardium D009928:Organ Specificity D012038:Regeneration D044968:Regenerative Medicine D013314:Stress, Mechanical D023822:Tissue Engineering D054457:Tissue Scaffolds D020257:Ventricular Remodeling
Extracellular matrix Cardiac patch Decellularization Heart valves Hydrogels Macrophage Whole-organ engineering