Computed tomography enterography for crohn's disease: correlation between the imaging findings and histopathologic scoring system.
OBJECTIVES
The aim of this study was to retrospectively determine if quantitative measurements of computed tomography enterography (CTE) imaging findings correlate with histopathologic scores from biopsy specimens in patients with Crohn's disease (CD).


METHODS
CTE datasets of 34 CD patients (19 male and 15 female) who underwent endoscopy with biopsy within 25 days before or after CTE were retrospectively reviewed. CTE findings of segmental mural hyperenhancement, wall thickening, mural stratification and mesenteric findings were quantitatively measured in the corresponding segment. Histopathologic score of CD was based upon the Naini Cortina scoring system. Correlation between CTE findings and histopathologic scores was assessed using Spearman's rank correlation and logistic or linear regression analysis.


RESULTS
Neutrophilic inflammation contributed the most to the segmental mural hyperenhancement and explained 38.4% of the variance (R2 = 0.384, P = 0.006). Moreover, the increased lymphocytes and plasma cells predicted larger lymph node (P = 0.003) and increased attenuation in mesenteric fat (P = 0.022).


CONCLUSIONS
To a certain extent, macroscopic CTE findings may reflect the microscopic histopathologic state in the inflammatory stage of CD, underscoring that establishment of CTE scoring system may potentially provide an objective tool for assessment of disease progression.
['Ma|Liang|L|0000-0003-1297-3283', 'Shen|Xing|X|', 'Chen|Yi-Jing|YJ|', 'Zhang|Qi|Q|', 'Li|Bo|B|', 'Zhang|Wei|W|']
D003424:Crohn Disease D005260:Female D006801:Humans D007249:Inflammation D008297:Male D008643:Mesentery D012189:Retrospective Studies D014057:Tomography, X-Ray Computed
Computed tomography enterography Histopathologic score Crohn’s disease