Clinical implications of pathologic factors after thyroid lobectomy in patients with papillary thyroid carcinoma.
OBJECTIVE
We evaluated the clinical and prognostic significance of pathologic factors by analyzing the treatment results of patients who underwent thyroid lobectomy.


MATERIALS AND METHODS
We retrospectively analyzed data from 734 patients diagnosed with papillary thyroid cancer who underwent thyroid lobectomy at Korea University Hospital from January 2004 to December 2016.


RESULTS
A total of 734 patients were included in the study and their mean age was 44.5 years (range, 15-83). On univariate analysis, tumor size and recurrence-free survival were significantly related. The 10-year recurrence-free survival was 98.3% for tumors ≤1cm, 77.8% for >1cm and ≤2cm, and 66.7% for >2cm (p = 0.014). Recurrence-free survival was significantly different between patients with and without microscopic extrathyroidal extension (p=0.002). The 10-year recurrence-free survival rate was 99.2% for patients without extrathyroidal extension and 92.2% for patients with microscopic extrathyroidal extension. Multivariate analysis showed only microscopic extrathyroidal extension was significantly correlated with recurrence-free survival (p=0.029).


CONCLUSION
In patients undergoing thyroid lobectomy for low-risk papillary thyroid cancer, microscopic extrathyroidal extension was an important prognostic factor associated with recurrence-free survival. However, in cases with microscopic extrathyroidal extension findings on postoperative pathologic examination, appropriate ultrasonographic follow-up of the contralateral thyroid lobe and cervical lymph node to facilitate early detection and prompt treatment of recurrence can control the disease without a deterioration of survival rate.
['Park|Young Min|YM|', 'Lee|Doh Young|DY|', 'Oh|Kyung Ho|KH|', 'Cho|Jae-Gu|JG|', 'Baek|Seung-Kuk|SK|', 'Kwon|Soon-Young|SY|', 'Jung|Kwang-Yoon|KY|', 'Woo|Jeong-Soo|JS|']
D000293:Adolescent D000328:Adult D000368:Aged D000369:Aged, 80 and over D002291:Carcinoma, Papillary D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D009361:Neoplasm Invasiveness D012008:Recurrence D012189:Retrospective Studies D016019:Survival Analysis D000077273:Thyroid Cancer, Papillary D013964:Thyroid Neoplasms D013965:Thyroidectomy D047368:Tumor Burden D055815:Young Adult
Pathologic factor Thyroid lobectomy Papillary thyroid carcinoma Microscopic extrathyroidal extension Recurrence