Sexual Dysfunction in a Patient Taking Ledipasvir/Sofosbuvir for the Treatment of Hepatitis C: A Case Report.
Sexual dysfunction is a bothersome side effect of several medications, though it has not yet been reported with the use of ledipasvir/sofosbuvir for the treatment of hepatitis C. However, sexual dysfunction is a potentially unrecognized side effect of ledipasvir/sofosbuvir that could result in nonadherence and treatment failure. We report a case of a 42-year-old man with a sudden onset of sexual dysfunction with the initiation of ledipasvir/sofosbuvir for the treatment of hepatitis C. The patient had no prior history or risk factors for the development of sexual dysfunction. His symptoms resolved upon discontinuation of ledipasvir/sofosbuvir after a successful 12-week course. Clinicians should be aware that sexual dysfunction is a possible side effect of ledipasvir/sofosbuvir and educate patients appropriately. Adherence should be emphasized as the risks of untreated hepatitis C virus far outweigh transient sexual dysfunction.
['Lenz|Destin U|DU|', 'Crutcher|Effie L|EL|', 'Greene|Elisa M|EM|']
D000328:Adult D000998:Antiviral Agents D001562:Benzimidazoles D064420:Drug-Related Side Effects and Adverse Reactions D005449:Fluorenes D006526:Hepatitis C D006801:Humans D008297:Male D012735:Sexual Dysfunction, Physiological D000069474:Sofosbuvir D014542:Uridine Monophosphate
sexual dysfunction ledipasvir/sofosbuvir hepatitis C virus Harvoni®