MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1.
MicroRNAs (miRNAs) play critical roles in breast cancer cell biological processes, including proliferation and apoptosis by inhibiting the expression of their target genes. Herein, we reported that miR-630 overexpression initiates apoptosis, blocks cell cycle progression and suppresses cell proliferation in breast cancer cells. Furthermore, BMI1, a member of polycomb group family, was identified as a direct target of miR-630, and there was a negative correlation between the expression levels of BMI1 and miR-630 in human breast cancer samples. With a series of biology approaches, subsequently, we proved that BMI1 was a functional downstream target of miR-630 and mediated the property of miR-630-dependent inhibition of breast cancer progression. Taken together, these findings provide further evidence on the tumor-suppression function of miR-630 in breast cancer, and clarify BMI1 as a novel functional target gene of miR-630.
['Gong|Xiu-Feng|XF|', 'Yu|An-Lu|AL|', 'Tang|Jun|J|', 'Wang|Chen-Long|CL|', 'He|Jian-Rong|JR|', 'Chen|Guo-Qiang|GQ|', 'Zhao|Qian|Q|', 'He|Ming|M|', 'Zhou|Ci-Xiang|CX|']
D017209:Apoptosis D001943:Breast Neoplasms D045744:Cell Line, Tumor D049109:Cell Proliferation D005260:Female D015972:Gene Expression Regulation, Neoplastic D006801:Humans D035683:MicroRNAs D048054:Mitogen-Activated Protein Kinase 7
Breast cancer BMI1 Apoptosis miR-630