Clopidogrel Hypersensitivity: Pathogenesis, Presentation and Diagnosis.
This paper provides an overview of the pathogenesis, presentation and diagnosis of clopidogrel hypersensitivity. The majority of clopidogrel hypersensitivity cases are due to a T cell mediated Gell and Coombs Type IV reaction. History, histology, and patch testing have shown consistency with a T cell mediated mechanism. Clopidogrel reactions most commonly present as a mild delayed maculopapular erythematous rash 5 to 10 days after introduction of the drug, and do not always require discontinuation of the drug. Severe cutaneous, systemic, and immediate adverse reactions to clopidogrel are rare. For the diagnosis of clopidogrel hypersensitivity, drug causality can be determined using patch testing, or for mild reactions, recurrence of symptoms after drug reintroduction, although neither are required for diagnosis.
['Ford|Megan K|MK|', 'Cohn|John R|JR|']
D002318:Cardiovascular Diseases D000077144:Clopidogrel D004342:Drug Hypersensitivity D006801:Humans D010328:Patch Tests D010974:Platelet Aggregation D010975:Platelet Aggregation Inhibitors D011237:Predictive Value of Tests D058921:Purinergic P2Y Receptor Antagonists D012307:Risk Factors D012720:Severity of Illness Index D016896:Treatment Outcome
Clopidogrel hypersensitivity diagnosis clopidogrel allergy drug allergy pathogenesis.