Response of the antioxidant enzymes of the erythrocyte and alterations in the serum biomarkers in rats following oral administration of nanoparticles.
In this study, Al2O3, CuO and TiO2 nanoparticles (NPs) were administered to mature female rats (Rattus norvegicus var. albinos) via oral gavage (0, 0.5, 5, 50mg/kg b.w./day) for 14days to investigate their effects on 14 serum biomarkers and 4 antioxidant enzyme (catalase, superoxide dismutase, glutathione peroxidase, glutathione S-transferase) activities in the erythrocyte. Data showed that Al2O3 did not cause any significant (P>0.05) change in the parameters, except few cases, while CuO and TiO2 caused significant alterations in antioxidant system parameters of the erythrocytes. Activities of catalase and superoxide dismutase significantly decreased in CuO and TiO2 administered rats. Oppositely, glutathione peroxidase activity increased in CuO and TiO2 administered rats. There were no significant alterations in the activity of glutathione S-transferase in the erythrocytes. Levels of glucose, cholesterol, bilirubin, triglyceride, triiodothyronine (T3), estradiol, prolactin and immunoglobulin M (IgM) in the serum altered after some of NP administrations, whereas cortisol, protein, creatinine, blood urea nitrogen (BUN), thyroxine (T4) and immunoglobulin G (IgG) levels in the serum did not change significantly after any of NP administration. There were outstanding increases in the levels of bilirubin and prolactin and decreases in the levels of triglyceride and estradiol. The present study demonstrated that the antioxidant enzymes in the erythrocyte were generally affected from copper and titanium NPs, while aluminium and copper NPs caused more significant alterations in serum biomarkers.
['Canli|Esin G|EG|', 'Atli|Gülüzar|G|', 'Canli|Mustafa|M|']
D000284:Administration, Oral D000537:Aluminum Oxide D000818:Animals D015415:Biomarkers D003300:Copper D004912:Erythrocytes D005260:Female D015971:Gene Expression Regulation, Enzymologic D005979:Glutathione Peroxidase D005982:Glutathione Transferase D053768:Metal Nanoparticles D018384:Oxidative Stress D051381:Rats D013482:Superoxide Dismutase D014025:Titanium
Antioxidant Erythrocyte Serum Rat Nanoparticle Metal