Small non-coding RNAs-based bone regulation and targeting therapeutic strategies.
Small non-coding RNAs, which are 20-25 nucleotide ribonucleic acids, have emerged as an important transformation in the biological evolution over almost three decades. microRNAs (miRNAs) and short interfering RNAs (siRNAs) are two significant categories of the small RNAs that exert important effects on bone endocrinology and skeletology. Therefore, clarifying the expression and function of these important molecules in bone endocrine physiology and pathology is of great significance for improving their potential therapeutic value for metabolism-associated bone diseases. In the present review, we highlight the recent advances made in understanding the function and molecular mechanism of these small non-coding RNAs in bone metabolism, especially their potentially therapeutic values in bone-related diseases.
['Yang|Ying|Y|', 'Fang|Sijie|S|']
D051701:Activating Transcription Factor 4 D000818:Animals D001859:Bone Neoplasms D001842:Bone and Bones D050659:Core Binding Factor Alpha 1 Subunit D005786:Gene Expression Regulation D006801:Humans D035683:MicroRNAs D058990:Molecular Targeted Therapy D010003:Osteoarthritis D010006:Osteoblasts D010024:Osteoporosis D034741:RNA, Small Interfering D015398:Signal Transduction D000076182:Sp7 Transcription Factor D051176:beta Catenin
Targeting therapeutics miRNA siRNA Bone metabolism