Are Lethal Alleles Too Abundant in Humans?
Across species, many individuals carry one or more recessive lethal alleles, posing an evolutionary conundrum for their persistence. Using a population genomic approach, Amorim et al. studied the abundance of lethal disease-causing mutations in humans and found that, while appearing more common than expected, most may nonetheless persist at frequencies predicted by mutation-selection balance.
['Ballinger|Mallory A|MA|', 'Noor|Mohamed A F|MAF|']
D000483:Alleles D005804:Genes, Lethal D005808:Genes, Recessive D006801:Humans D009154:Mutation
lethal alleles humans autosomal recessive disease mutation–selection balance