Assessment of serum synuclein-γ and squamous cell carcinoma antigen as diagnostic biomarkers in patients with oral squamous cell carcinoma and oral potentially malignant disorders.
BACKGROUND
Clinical diagnosis and monitoring are crucial to reduce the mortality from oral squamous cell carcinoma (OSCC) and oral potentially malignant disorders (OPMDs). It has been demonstrated that synuclein-γ (SNCG) and squamous cell carcinoma antigen (SCCAg) are highly expressed in patients with OSCC and perhaps participate in OSCC progression. This study analyzed the levels of serum SNCG and SCCAg in OSCC, OPMD, and control patients, and evaluated the diagnostic and clinical value of single and combined detection of serum SNCG and SCCAg in OSCC and OPMDs.


PATIENTS AND METHODS
Serum samples were collected from 197 patients including 87 patients with OSCC, 30 patients with OPMDs, and 80 healthy volunteers as controls. Enzyme-linked immunosorbent assay and statistical analysis were utilized to determine SNCG and SCCAg levels in serum.


RESULTS
The levels of SNCG and SCCAg in serum were significantly higher in OSCC compared with OPMDs and controls. There was a correlation between SNCG level and ethnicity, and SCCAg was correlated with differentiation. Furthermore, the area under the curves, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of combined detection of SNCG and SCCAg were better than any single detection.


CONCLUSION
The combined detection of SNCG and SCCAg in serum could become a new standard method to distinguish between OSCC and OPMDs and improve diagnostic performance for OSCC.
['Chen|Leiyu|L|', 'Luo|Ting|T|', 'Yang|Jie|J|', 'Wang|Keying|K|', 'Liu|Shiyu|S|', 'Wei|Yi|Y|', 'Liu|Han|H|', 'Xu|Jiang|J|', 'Zheng|Jun|J|', 'Zeng|Yan|Y|https://orcid.org/0000-0002-9823-1266']
D000951:Antigens, Neoplasm D014408:Biomarkers, Tumor D002294:Carcinoma, Squamous Cell D006258:Head and Neck Neoplasms D006801:Humans D009062:Mouth Neoplasms D015843:Serpins D000077195:Squamous Cell Carcinoma of Head and Neck D051843:Synucleins
serum squamous cell carcinoma antigen Biomarker oral squamous cell carcinoma oral potentially malignant disorders gamma-synuclein