An effective thermal therapy against cancer using an E-jet 3D-printing method to prepare implantable magnetocaloric mats.
Magnetic hyperthermia has been rapidly developed as a potential cancer treatment in recent years. Artificially induced hyperthermia close to a tumor can raise the temperature to 45°C causing tumor cell death. Herein, we introduce a novel method for rapid preparation of anti-cancer magnetocaloric PCL/Fe3 O4 mats capable of high-performance hyperthermia using E-jet 3D printing technology. Our 3D printed mats not only maintained the heating efficiency of traditional techniques for magnetic hyperthermia but also prolonged the effective therapy in vivo. When Fe3 O4 nanoparticles (NPs) were used in mats at a concentration of 6 mmol/L, 0.07 g PCL/Fe3 O4 mats were able to increase the temperature peripherally to 45°C under an alternating magnetic field (AMF) within 45 min. Moreover, the reproducibility experiment indicated that the maximum temperature was achieved following repeated heating and cooling cycles. Cell toxicity tests showed a high cell death rate during one treatment cycle. In vivo experiments indicated clear signs of tumor growth inhibitory and prolonged survival time of tumor-bearing mice after 4 weeks of treatment. The present magnetic mats may be a potential candidate for a novel heat-generating substrate for localized hyperthermia cancer therapy. Furthermore, the main advantage of such implantable magnetic mats is the local and precise delivery of Fe3 O4 NPs, ideal for the hyperthermia treatment of easily accessible tumors. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1827-1841, 2018.
['Yang|Yikun|Y|', 'Tong|Chunyi|C|', 'Zhong|Juchang|J|', 'Huang|Ruiying|R|', 'Tan|Weihong|W|', 'Tan|Zhikai|Z|']
D000818:Animals D045325:HCT116 Cells D006801:Humans D006979:Hyperthermia, Induced D060526:Magnetic Fields D058185:Magnetite Nanoparticles D008297:Male D051379:Mice D008807:Mice, Inbred BALB C D008819:Mice, Nude D041681:NIH 3T3 Cells D009374:Neoplasms, Experimental D066330:Printing, Three-Dimensional D023041:Xenograft Model Antitumor Assays
thermal therapy anti-cancer E-jet 3D printing magnetic nanoparticles mats precise drug delivery