The effects of neurochemical balance in the anterior cingulate cortex and dorsolateral prefrontal cortex on volitional control under irrelevant distraction.
Volitional control has been related to the excitatory/inhibitory (E/I) ratio of glutamate-glutamine to γ-aminobutyric acid concentration in the different parts of the frontal cortex. Yet, how the neurochemical balance in each of the brain areas modulates volitional control remains unclear. Here, participants performed an auditory Go/No-Go task with and without task-irrelevant face distractors. Neurochemical balance was measured with magnetic resonance spectroscopy at rest. Participants with higher E/I ratios in the dorsolateral prefrontal cortex (DLPFC) showed less control over No-Go cues under no distraction, whereas participants with higher E/I ratios in the anterior cingulate cortex (ACC) were more prompted to make speeded Go responses under distraction. Therefore, the neurochemical balance in the DLPFC and ACC may be involved in the control over task-relevant and -irrelevant cues respectively.
['Koizumi|Ai|A|', 'Lau|Hakwan|H|', 'Shimada|Yasuhiro|Y|', 'Kondo|Hirohito M|HM|']
D000328:Adult D056344:Executive Function D005260:Female D018698:Glutamic Acid D005973:Glutamine D006179:Gyrus Cinguli D006801:Humans D007266:Inhibition, Psychological D009682:Magnetic Resonance Spectroscopy D008297:Male D008875:Middle Aged D017397:Prefrontal Cortex D011597:Psychomotor Performance D014836:Volition D055815:Young Adult D005680:gamma-Aminobutyric Acid
Volitional control Go/No-Go task Dorsolateral prefrontal cortex (DLPFC) Anterior cingulate cortex (ACC) Magnetic resonance spectroscopy (MRS)