In vitro evaluation of electrospun PLGA/PLLA/PDLLA blend fibers loaded with naringin for guided bone regeneration.
The present study was to evaluate fiber mesh loaded with naringin via electrospinning to guide bone regeneration in vitro. The naringin-loaded fiber mesh was prepared via elctrospinning of PLGA, PLLA, PDLLA blending solution with naringin. SEM showed that naringin decreased the fiber's diameter according to the concentration of naringin. After 20 days' degradation in PBS, the drug-loaded fiber meshes still kept their stability with about 10% decrease in tensile strength. In vitro release experiments showed a sustained and steady naringin releasing profile with little initial burst releasing. Compared to the mats without naringin, the fiber mats loaded with naringin showed the most pronounced enhancement of cell growth when MC3T3-E1 cells were cultured on the fiber mats. The blend fiber loaded with naringin has optimized physical properties and sustained release profile in vitro. The study presents a promising fibrous mesh material for guided bone regeneration therapy.
['Guo|Zhenzhao|Z|', 'Wu|Shuai|S|', 'Li|Hong|H|', 'Li|Qiyan|Q|', 'Wu|Gang|G|', 'Zhou|Changren|C|']
D001672:Biocompatible Materials D001861:Bone Regeneration D002152:Calorimetry, Differential Scanning D002478:Cells, Cultured D044950:Flavanones D008422:Materials Testing D057139:Nanofibers D011091:Polyesters D000077182:Polylactic Acid-Polyglycolic Acid Copolymer D054457:Tissue Scaffolds
PLGA/PLLA/PDLLA Naringin Guided bone regeneration Electrospinning