Efficacy and safety of tamsulosin hydrochloride 0.2 mg and combination of tamsulosin hydrochloride 0.2 mg plus solifenacin succinate 5 mg after transurethral resection of the prostate: a prospective, randomized controlled trial.
OBJECTIVE
The objective of this study was to evaluate the safety and efficacy of tamsulosin hydrochloride 0.2 mg (TAM) and its combination with solifenacin succinate 5 mg (SOL) after transurethral resection of the prostate (TURP).


PATIENTS AND METHODS
The patients were randomized into three groups: TURP (group 1), TURP plus TAM (group 2), and TURP plus TAM + SOL (group 3). Patients in group 2 and group 3 received medication for 4 weeks. The primary efficacy end points were the mean change in total International Prostate Symptom Score (IPSS) and IPSS subscores. The secondary end points included quality-of-life score, Overactive Bladder Symptom Score, and short-form voiding and storage score of International Continence Society.


RESULTS
In total, 37 men (31.8%) in group 1, 37 men (31.8%) in group 2, and 42 men (36.2%) in group 3 completed the study. In total IPSS, no significant improvement was seen from baseline to the end of treatment in groups 2 and 3 compared with group 1. However, in group 2, the decrement in the IPSS storage score was smaller than group 1 (P=0.02), and in group 3, the decrement in the IPSS voiding score was smaller than group 1 (P=0.05). In groups 2 and 3 compared with group 1, improvements in the quality of life score, total score of Overactive Bladder Symptom Score, and short-form voiding score and storage score of International Continence Society were not statistically significant.


CONCLUSION
Treatment with TAM and combination of TAM and SOL did not have significant additional benefits for lower urinary tract symptoms during the early recovery period after TURP.
['Shin|Yu Seob|YS|', 'Zhang|Li Tao|LT|', 'You|Jae Hyung|JH|', 'Choi|In Sung|IS|', 'Zhao|Chen|C|', 'Park|Jong Kwan|JK|']
D000368:Aged D000369:Aged, 80 and over D004359:Drug Therapy, Combination D006801:Humans D059411:Lower Urinary Tract Symptoms D008297:Male D008875:Middle Aged D011446:Prospective Studies D011788:Quality of Life D000069464:Solifenacin Succinate D013449:Sulfonamides D000077409:Tamsulosin D020728:Transurethral Resection of Prostate D016896:Treatment Outcome D053201:Urinary Bladder, Overactive D064804:Urological Agents
tamsulosin combination solifenacin transurethral resection of the prostate benign prostate hyperplasia