Motor and non-motor symptoms in old-age onset Parkinson's disease patients.
Advancing age is a well-known risk factor for Parkinson's disease (PD). With population ageing it is expected that the total number of patients with PD onset at oldage increases. Information on the motor but particularly on non-motor phenotype of this late-onset population is lacking. We recruited 24 patients with PD onset at or over 75 years. Each patient was matched with 1 control patient with PD onset between the ages of 40 and 65 and matched for disease duration. Both groups were assessed with the UPDRS, the Non-motor symptoms scale (NMSS) and other scales to assess non-motor symptoms. Groups were compared with conditional logistic regression analysis. Old-age onset PD was, on average, 80 years at the time of PD onset while middle-age onset were 59. Disease duration was approximately 5 years in both groups. While no difference was observed in the total UPDRS-III scores, old-age onset PD was associated with higher axial symptoms (7.42 vs. 4.63, p = 0.011) and a higher frequency of dementia (7/24 vs. 0/24, p = 0.009). While no difference in the total number of non-motor symptoms was observed (6.79 vs. 6.22, p = 0.310), old-age onset patients had a higher prevalence of gastrointestinal symptoms (20/24 vs. 12/24, p = 0.037). For the same disease duration, older age onset is associated with worse axial motor dysfunction and dementia in PD patients. Beside gastrointestinal symptoms, non-motor symptoms are not associated with age.
['Mendonça|Marcelo D|MD|0000-0003-3587-8553', 'Lampreia|Tania|T|', 'Miguel|Rita|R|', 'Caetano|André|A|', 'Barbosa|Raquel|R|', 'Bugalho|Paulo|P|']
D000328:Adult D017668:Age of Onset D000368:Aged D000369:Aged, 80 and over D016022:Case-Control Studies D003704:Dementia D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D000068079:Motor Disorders D010300:Parkinson Disease D015995:Prevalence
Non-motor symptoms Parkinson's Disease Age Axial symptoms Dementia