Circadian disruption in the pathogenesis of metabolic syndrome.
Metabolic syndrome is a multifactorial process induced by a combination of genetic and environmental factors and recent evidence has highlighted that circadian disruption and sleep loss contribute to disease pathogenesis. Emerging work in experimental genetic models has provided insight into the mechanistic basis for clock disruption in disease. Indeed, disruption of the clock system perturbs both neuroendocrine pathways within the hypothalamus important in feeding and energetics, in addition to peripheral tissues involved in glucose and lipid metabolism. This review illustrates the impact of molecular clock disruptions at the level of both brain and behavior and peripheral tissues, with a focus on how such dysregulation in turn impacts lipid and glucose homeostasis, inflammation and cardiovascular function. New insight into circadian biology may ultimately lead to improved therapeutics for metabolic syndrome and cardiovascular disease in humans.
['Maury|E|E|', 'Hong|H K|HK|', 'Bass|J|J|']
D056926:CLOCK Proteins D002318:Cardiovascular Diseases D002940:Circadian Rhythm D004734:Energy Metabolism D005786:Gene Expression Regulation D005947:Glucose D006706:Homeostasis D006801:Humans D007031:Hypothalamus D007249:Inflammation D050356:Lipid Metabolism D008055:Lipids D024821:Metabolic Syndrome D015398:Signal Transduction D012892:Sleep Deprivation
Metabolism Cardiovascular disease Circadian rhythm