Investigating metabolic regulation using targeted neuromodulation.
The central nervous system (CNS) plays a vital role in regulating energy balance and metabolism. Over the last 50 years, studies in animal models have allowed us to identify critical CNS regions involved in these processes and even crucial cell populations. Now, techniques for genetically and anatomically targeted manipulation of specific neural populations using light (optogenetic), ligands (chemogenetic), or magnetic fields (radiogenetic/magnetogenetic) allow detailed investigation of circuits involved in metabolic regulation. In this review, we provide a brief overview of recent studies using light- and magnetic field-regulated neural activity to investigate the neural circuits contributing to metabolic control.
['Devarakonda|Kavya|K|', 'Stanley|Sarah|S|0000-0002-0253-2663']
D000818:Animals D001066:Appetite D002490:Central Nervous System D004574:Electromagnetic Fields D004734:Energy Metabolism D004867:Equipment Design D005247:Feeding Behavior D005786:Gene Expression Regulation D005947:Glucose D006706:Homeostasis D006801:Humans D007031:Hypothalamus D007473:Ion Channels D007834:Lasers D058185:Magnetite Nanoparticles D009474:Neurons D062308:Optogenetics D015202:Protein Engineering D043562:Receptors, G-Protein-Coupled
metabolism optogenetics radiogenetics magnetogenetics feeding glucose