Contrast-Enhanced Ultrasound Quantification Assessment of Focal Fatty Variations in Liver Parenchyma: Challenging the Traditional Qualitative Paradigm of Uniform Enhancement With Adjacent Parenchyma.
OBJECTIVES
The purpose of this study was to quantify contrast-enhanced ultrasound enhancement of focal fatty sparing (FFS) and focal fatty infiltration (FFI) and compare it with adjacent liver parenchyma.


METHODS
This was a retrospective observational study yielding 42 cases in the last 4 years. Inclusion criteria were a focal liver lesion, adequate video availability, and an established diagnosis of FFS or FFI based on clinical or imaging follow-up or a second modality. Contrast-enhanced ultrasound examinations were performed with a standard low-mechanical index technique. Commercially available software calculated quantitative parameters for a focal liver lesion and a reference area of liver parenchyma, producing relative indices.


RESULTS
In total, 42 patients were analyzed (19 male) with a median age of 18 (interquartile range, 42) years and a median lesion diameter of 30 (interquartile range, 16) mm. The cohort included 26 with FFS and 16 with FFI. Subjectively assessed, 27% of FFS and 25% of FFI were hypoenhancing in the arterial phase, and 73% of FFS and 75% of FFI were isoenhancing. In the venous and delayed phases, all lesions were isoenhancing. The peak enhancement (P = .001), wash-in area under the curve (P < .01), wash-in rate (P = .023), and wash-in perfusion index (P = .001) were significantly lower in FFS compared with adjacent parenchyma but not the mean transit time. In the FFI subgroup, no significant difference was detected. Comparing relative parameters, only the wash-in rate was significantly (P = .049) lower in FFS than FFI. The mean follow-up was 2.8 years.


CONCLUSIONS
Focal fatty sparing shows significantly lower and slower enhancement than the liver parenchyma, whereas FFI enhances identically. Focal fatty sparing had a significantly slower enhancement than FFI.
['Rafailidis|Vasileios|V|https://orcid.org/0000-0002-0284-4106', 'Fang|Cheng|C|https://orcid.org/0000-0001-9649-8904', 'Leenknegt|Benjamin|B|', 'Ballal|Khalid|K|', 'Deganello|Annamaria|A|', 'Sellars|Maria E|ME|', 'Yusuf|Gibran T|GT|', 'Huang|Dean Y|DY|', 'Sidhu|Paul S|PS|https://orcid.org/0000-0003-1928-4077']
D000328:Adult D003287:Contrast Media D006801:Humans D008099:Liver D008113:Liver Neoplasms D008297:Male D012189:Retrospective Studies D014463:Ultrasonography
contrast-enhanced ultrasound quantification liver perfusion steatosis