Prenatal Exposure to Angiotensin II Receptor Blockers and Hemodynamic Effects on the Newborn.
Angiotensin II receptor blockers (ARBs) are potent antihypertensive agents that block the renin angiotensin aldosterone system (RAS). Their use in pregnancy may cause malformations, oligoanuria, hypotension, and death. Hypotension is observed up to 15% of cases and is described as refractory to volume and inotropic support, although its pathophysiology is unknown. We present a case of prenatal exposure to ARBs in order to characterize the hemodynamic compromise in the newborn, help in decision-making, and guide the therapeutic approach to these patients.
['Rodríguez-Castaño|MaJosé|M|', 'Corredera|Araceli|A|', 'Aleo|Esther|E|', 'Arruza|Luis|L|']
D000328:Adult D057912:Angiotensin II Type 2 Receptor Blockers D000959:Antihypertensive Agents D005260:Female D006439:Hemodynamics D006801:Humans D006973:Hypertension D007231:Infant, Newborn D011247:Pregnancy D011256:Pregnancy Outcome D011297:Prenatal Exposure Delayed Effects D012084:Renin-Angiotensin System
angiotensin II receptor blockers newborn hypotension refractory