Impact of Candida auris Infection in a Neutropenic Murine Model.
Candida auris has become a global public health threat due to its multidrug resistance and persistence. Currently, there are limited murine models to study C. auris infection. Those models use a combination of cyclophosphamide and cortisone acetate, suppressing both innate and adaptive immunity. Here, we compare C. auris infection in two neutrophil-depleted murine models in which innate immunity is targeted using the monoclonal antibodies 1A8 and RB6-8C5.
['Torres|Steven R|SR|', 'Pichowicz|Amber|A|', 'Torres-Velez|Fernando|F|', 'Song|Renjie|R|', 'Singh|Navjot|N|', 'Lasek-Nesselquist|Erica|E|', 'De Jesus|Magdia|M|0000-0002-0713-8462']
D000818:Animals D000911:Antibodies, Monoclonal D002175:Candida D002177:Candidiasis D003348:Cortisone D003520:Cyclophosphamide D004195:Disease Models, Animal D007113:Immunity, Innate D051379:Mice D009504:Neutrophils
Candida auris Ly6C Ly6G microbiome neutrophil depletion torticollis