RELL1, a novel oncogene, accelerates tumor progression and regulates immune infiltrates in glioma.
BACKGROUND
Diffuse gliomas are the most prevalent primary brain tumors. The Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) databases provide evidence of the relationships between gliomas and altered molecular pathways. In glioma pathogenesis, the microenvironment has emerged as a potential indicator of tumor progression.


METHODS
We investigated and confirmed the role of RELT-like 1 (RELL1) oncogene in glioblastoma and low-grade glioma by data mining large cohorts of TCGA and the CGGA. Correlations between immune cells and RELL1 were verified using the CIBERSORT algorithm.


RESULTS
Our analysis revealed that RELL1 expression was much higher in grade-dependent glioma patients with poor prognosis. Comparable prognostic values for isocitrate dehydrogenase 1 (IDH1) and RELL1 were observed during in-depth analyses of the integrated correlations. Moreover, RELL1 was found to be associated with numerous tumor-infiltrating immune cells in glioma-affected patients.


CONCLUSION
We conclude that RELL1 might serve as a potential therapeutic target or prognostic marker in glioblastoma and diffuse glioma cases.
['Jin|Xiaohong|X|', 'Xie|Huiwen|H|', 'Liu|Xiaoman|X|', 'Shen|Qiuyan|Q|', 'Wang|Ziheng|Z|', 'Hao|Haiyan|H|', 'Gu|Yan|Y|']
D000328:Adult D014408:Biomarkers, Tumor D001932:Brain Neoplasms D002352:Carrier Proteins D018450:Disease Progression D005260:Female D015972:Gene Expression Regulation, Neoplastic D005910:Glioma D006801:Humans D008297:Male D008565:Membrane Proteins D009857:Oncogenes D011379:Prognosis D016016:Proportional Hazards Models
RELL1 Glioma CGGA TCGA NK cells