Urinary metabolites of organophosphate esters: Concentrations and age trends in Australian children.
There is growing concern around the use of organophosphate esters (OPEs) due to their suspected reproductive toxicity, carcinogenicity, and neurotoxicity. OPEs are used as flame retardants and plasticizers, and due to their extensive application in consumer products, are found globally in the indoor environment. Early life exposure to OPEs is an important risk factor for children's health, but poorly understood. To study age and sex trends of OPE exposures in infants and young children, we collected, pooled, and analysed urine samples from children aged 0-5years from Queensland, Australia for 9 parent OPEs and 11 metabolites. Individual urine samples (n=400) were stratified by age and sex, and combined into 20 pools. Three individual breast milk samples were also analysed to provide a preliminary estimate on the contribution of breast milk to the intake of OPEs. Bis(1-chloroisopropyl) phosphate (BCIPP), 1-hydroxy-2-propyl bis(1-chloro-2-propyl) phosphate (BCIPHIPP), bis(1,3-dichloroisopropyl) phosphate (BDCIPP), dibutyl phosphate (DBP), diphenyl phosphate (DPHP), bis(2-butoxyethyl) phosphate (BBOEP), bis(2-butoxyethyl) 3-hydroxyl-2-butoxyethyl phosphate (3OH-TBOEP), and bis(2-butoxyethyl) hydroxyethyl phosphate (BBOEHEP) were detected in all urine samples, followed by bis(methylphenyl) phosphate (80%), and bis(2-ethylhexyl) phosphate (BEHP, 20%), and bis(2-chloroethyl) phosphate (BCEP, 15%). Concentrations of tris(2-chloroethyl) phosphate (TCEP), BCEP, tris(2-ethylhexyl) phosphate (TEHP), and DBP decreased with age, while bis(methylphenyl) phosphate (BMPP) increased with age. Significantly higher concentrations of DPHP (p=0.039), and significantly lower concentrations of TEHP (p=0.006) were found in female samples compared to males. The estimated daily intakes (EDIs) via breastfeeding, were 4.6, 26 and 76ng/kg/day for TCEP, TBP and TEHP, respectively, and were higher than that via air and dust, suggesting higher exposure through consumption of breast milk.
['He|Chang|C|', 'Toms|Leisa-Maree L|LL|', 'Thai|Phong|P|', 'Van den Eede|Nele|N|', 'Wang|Xianyu|X|', 'Li|Yan|Y|', 'Baduel|Christine|C|', 'Harden|Fiona A|FA|', 'Heffernan|Amy L|AL|', 'Hobson|Peter|P|', 'Covaci|Adrian|A|', 'Mueller|Jochen F|JF|']
D001942:Breast Feeding D000067576:Child Health D002675:Child, Preschool D004391:Dust D004784:Environmental Monitoring D004952:Esters D005260:Female D005411:Flame Retardants D006801:Humans D007223:Infant D007231:Infant, Newborn D008297:Male D008895:Milk, Human D010755:Organophosphates D010968:Plasticizers D011793:Queensland
Metabolites Children Alternative flame retardants Biomonitoring Exposure assessment Organophosphate flame retardants