Serum high-density lipoprotein cholesterol and progression to arterial stiffness in middle-aged and elderly Chinese.
BACKGROUND AND AIMS
Low high-density lipoprotein cholesterol (HDL-c) is a risk factor for cardiovascular disease. Brachial-ankle pulse wave velocity (baPWV) is an indicator of arterial stiffness, which is recognized as a predictor of cardiovascular disease. The aim of this study was to investigate the association between HDL-c and baPWV among middle-aged and elderly Chinese.


METHODS
A total number of 1133 Chinese (430 men, 703 women) aged from 50 to 90 years old were recruited from Shanghai downtown district. The baPWV and major cardiovascular risk factors of the participants were measured.


RESULTS
Serum HDL-c was negatively correlated with baPWV (r = -0.143, P < 0.001) after adjustment for age and gender. Multivariate linear regression analysis demonstrated that age (P < 0.001), systolic blood pressure (P < 0.001), HDL-c (P < 0.001), smoking (P = 0.001), BMI (P = 0.002), fasting plasma glucose (P = 0.004), and white blood cell (P = 0.005) were independently associated with baPWV. After multiple adjustments, participants in the highest quartile of HDL-c had an odds ratio of 0.442 (95% CI 0.268-0.729) for developing high arterial stiffness compared with participants in the lowest quartile. The association remained significant after further adjustment for major cardiovascular risk factors.


CONCLUSION
HDL-c has an independent protective effect on arterial stiffness in middle-aged and elderly Chinese. Early detection of HDL-c level is important in high risk populations with arterial stiffness. Increasing HDL-c level may be an attractive therapeutic target for the prevention of arterial function and subsequent disease.
['Zhao|W W|WW|', 'Yang|Y H|YH|', 'Lu|B|B|', 'Feng|X C|XC|', 'He|M|M|', 'Yang|Z H|ZH|', 'Wen|J|J|', 'Zhang|Z Y|ZY|', 'Yang|Z|Z|', 'Li|Q|Q|', 'Ye|Z|Z|', 'Gong|W|W|', 'Hu|R M|RM|']
D000368:Aged D000369:Aged, 80 and over D000375:Aging D055109:Ankle Brachial Index D044466:Asians D015415:Biomarkers D001808:Blood Vessels D002318:Cardiovascular Diseases D002681:China D008076:Cholesterol, HDL D015331:Cohort Studies D018450:Disease Progression D005260:Female D006801:Humans D008297:Male D008875:Middle Aged D063177:Pulse Wave Analysis D012307:Risk Factors D014504:Urban Health D059289:Vascular Stiffness
Arterial stiffness High-density lipoprotein cholesterol (HDL-c) Brachial-ankle pulse wave velocity (baPWV)