Associations of organochlorine pesticides and polychlorinated biphenyls in visceral vs. subcutaneous adipose tissue with type 2 diabetes and insulin resistance.
Background exposure to organochlorine (OC) pesticides and polychlorinated biphenyls (PCBs) has been linked to type 2 diabetes. As OC pesticides and PCBs mainly accumulate in adipose tissue and there are physiological and clinical differences between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT), we explored if there were associations of OC pesticides and PCBs in VAT or SAT with type 2 diabetes and insulin resistance. Participants were 50 patients with or without type 2 diabetes who underwent surgery for either cancer or benign liver or gallbladder lesions. We analyzed 14 OC pesticides and 22 PCB congeners in both VAT and SAT. Insulin resistance was estimated using homeostasis model assessment (HOMA). Although concentrations of OC pesticides and PCBs were strongly correlated between VAT and SAT, absolute concentrations differed substantially between them. In particular, concentrations of all PCBs were consistently about 5-10 times higher in VAT than SAT, but these patterns were independent of diabetes status. Some OC pesticides or PCBs, such as dichlorodiphenyltrichloroethanes (DDTs), chlordanes, and PCBs with 5 or less chlorides showed significant associations with diabetes or insulin resistance. For example, when tertiles of concentration-based summary measures were used, adjusted ORs were 1.0, 2.3, and 9.0 (P trend=0.02) for DDTs in VAT and 1.0, 2.1, and 5.7 (P trend=0.08) for PCBs with 5 or less chlorides. This study generally confirmed previous findings using serum concentrations. It would be useful to study pharmacodynamics of POPs in VAT and SAT further.
['Kim|Ki-Su|KS|', 'Lee|Yu-Mi|YM|', 'Kim|Sang Geol|SG|', 'Lee|In-Kyu|IK|', 'Lee|Hyo-Jeong|HJ|', 'Kim|Ji-Hyun|JH|', 'Kim|Jeongkook|J|', 'Moon|Hyo-Bang|HB|', 'Jacobs|David R|DR|', 'Lee|Duk-Hee|DH|']
D000328:Adult D000368:Aged D003924:Diabetes Mellitus, Type 2 D004781:Environmental Exposure D004785:Environmental Pollutants D005260:Female D006801:Humans D006843:Hydrocarbons, Chlorinated D007333:Insulin Resistance D008297:Male D008875:Middle Aged D010575:Pesticides D011078:Polychlorinated Biphenyls D050151:Subcutaneous Fat
Organochlorine pesticides Organochlorine pesticides Polychlorinated biphenyls Polychlorinated biphenyls subcutaneous adipose tissue Adipose tissue Diabetes Insulin resistance PCBs OC pesticides visceral adipose tissue VAT SAT ORs dichlorodiphenyltrichloroethanes DDTs chlordanes POPs CHLs HCB HCHs HOMA–IR LOD hexachlorobenzene hexachlorocyclohexanes homeostasis model assessment–insulin resistance limit of detection odds ratios organochlorine pesticides persistent organic pollutants polychlorinated biphenyls