Macro and small over micro: macromolecules and small molecules that regulate microRNAs.
Given the correlation between the deregulation of specific miRNAs and disease onset, it is critical to identify miRNA regulators that effectively control miRNAs involved in the pathogenesis of target diseases. This review provides the latest update on oligonucleotide- and small-molecule-based miRNA regulators, and discusses assays developed to screen for small-molecule regulators.
['Kang|Soowon|S|', 'Im|Kyungtaek|K|', 'Baek|Jihae|J|', 'Yoon|Sungroh|S|', 'Min|Hyeyoung|H|']
D040761:Biomimetic Materials D006801:Humans D046911:Macromolecular Substances D035683:MicroRNAs D016376:Oligonucleotides, Antisense D015203:Reproducibility of Results D054852:Small Molecule Libraries D013379:Substrate Specificity
small molecules regulators microRNAs RNA high-throughput screening