A Method to Investigate Astrocyte and Microglial Morphological Changes in the Aging Brain of the Rhesus Macaque.
With a rapidly aging population, studies of neuroinflammation and degeneration associated with eugeric aging are becoming critical. Using the unique archive at the Tulane National Primate Research Center as a resource, we have developed tools to quantify morphological changes in astrocytes and microglia across the life span of monkeys. This method can be used for morphometric studies of multiple parameters simultaneously in an unbiased manner.
['Chiu|Kevin B|KB|', 'Lee|Kim M|KM|', 'Robillard|Katelyn N|KN|', 'MacLean|Andrew G|AG|']
D000375:Aging D000818:Animals D001253:Astrocytes D015415:Biomarkers D001921:Brain D004268:DNA-Binding Proteins D005904:Glial Fibrillary Acidic Protein D007091:Image Processing, Computer-Assisted D007150:Immunohistochemistry D008253:Macaca mulatta D017628:Microglia D012984:Software
Astrocyte Aging Neuroinflammation Eugeric Microglia Neurodegeneration