Organ-specific regulatory T cells of thymic origin are expanded in murine prostate tumors.
Little is known about the relative contributions of self-specific regulatory T cells (Tregs) of thymic origin and induced Tregs generated extrathymically to the pool of tumor-infiltrating Tregs. We have recently demonstrated that thymic-derived Tregs reactive to a prostate-associated self antigen are highly and recurrently enriched within oncogene-driven murine prostate cancers.
['Malchow|Sven|S|', 'Leventhal|Daniel S|DS|', 'Savage|Peter A|PA|']
tumor cancer AIRE FOXP3 development induced regulatory T cells thymus