Solid-State Characterization and Biological Activity of Betulonic Acid Derivatives.
Betulonic acid belongs to the pentacyclic triterpenic derivative class and can be obtained through the selective oxidation of betulin. In this study we set obtaining several functionalized derivatives of this compound by its condensation with several amino compounds such as aminoguanidine, hydroxylamine, n-butylamine and thiosemicarbazide as our goal. The functionalization of the parent compound led to several molecules with antiproliferative potential, the most promising being 3-2-carbamothioylhydrazonolup-20(29)-en-28-oic acid.
['Ledeţi|Ionuţ|I|', 'Avram|Ştefana|Ş|', 'Bercean|Vasile|V|', 'Vlase|Gabriela|G|', 'Vlase|Titus|T|', 'Ledeţi|Adriana|A|', 'Zupko|Istvan|I|', 'Mioc|Marius|M|', 'Şuta|Lenuţa-Maria|LM|', 'Şoica|Codruţa|C|', 'Dehelean|Cristina|C|']
D000970:Antineoplastic Agents D002470:Cell Survival D006367:HeLa Cells D006801:Humans D061986:MCF-7 Cells D009828:Oleanolic Acid D017550:Spectroscopy, Fourier Transform Infrared
biological activity betulonic acid derivatives triterpene MTT assay synthesis thermal analysis