Impact of estimated-weight-base dose of alteplase in acute stroke treatment on clinical outcome.
Dosing of recombinant tissue plasminogen activator (rt-PA) for acute ischemic stroke treatment is often based on estimated body weight (BW) worldwide in routine clinical practice due to infeasible of accurate BW measurement. The aim of our study is to explore the impact of estimated BW when dosing rt-PA in acute ischemic stroke treatment on clinical outcome. Between January 2013 to May 2018, 126 acute ischemic stroke patients received intravenous rt-PA treatment based on estimated BW dosage were recruited. All patients had actual BW measured in ward after treatment. Based on the dosage of rt-PA given, patients were categorized into three groups, standard dose (0.8-1.0 mg/kg), overdose (>1.0 mg/kg), and underdose (<0.8 mg/kg). Among all 126 patients, 101 (80.2%) patients were treated with standard dose, 12 (9.5%) patients with overdose, and 13 (10.3%) patients with underdose of rt-PA respectively. There was no significant difference between demographic characteristics, pre-morbid risk factors, National Institutes of Health Stroke Scale (NIHSS) score at 24 h, NIHSS score at discharge, modified Rankin scale (mRS) within 0 to 2 in discharge or in 3 months after the event within the three groups. There was also no significant difference in hemorrhagic transformation and symptomatic intracranial hemorrhage (SICH). In conclusion, calculation of the dose of rt-PA based upon the estimated BW to treat acute ischemic stroke patients had no negative impact on the clinical outcome in our study.
['Cheng|Chi-Yung|CY|', 'Chen|Shih-Hsuan|SH|', 'Chen|Hsiu-Min|HM|', 'Li|Chao-Jui|CJ|', 'Liu|Tzu-Yun|TY|', 'Tan|Teng-Yeow|TY|']
D000368:Aged D001835:Body Weight D004305:Dose-Response Relationship, Drug D054796:Drug Dosage Calculations D005260:Female D005343:Fibrinolytic Agents D006801:Humans D008875:Middle Aged D012307:Risk Factors D020521:Stroke D015912:Thrombolytic Therapy D010959:Tissue Plasminogen Activator D016896:Treatment Outcome
Acute ischemic stroke treatment Body weight rt-PA dosing