Circadian Regulation of Macronutrient Absorption.
Various intestinal functions exhibit circadian rhythmicity. Disruptions in these rhythms as in shift workers and transcontinental travelers are associated with intestinal discomfort. Circadian rhythms are controlled at the molecular level by core clock and clock-controlled genes. These clock genes are expressed in intestinal cells, suggesting that they might participate in the circadian regulation of intestinal functions. A major function of the intestine is nutrient absorption. Here, we will review absorption of proteins, carbohydrates, and lipids and circadian regulation of various transporters involved in their absorption. A better understanding of circadian regulation of intestinal absorption might help control several metabolic disorders and attenuate intestinal discomfort associated with disruptions in sleep-wake cycles.
['Hussain|M Mahmood|MM|', 'Pan|Xiaoyue|X|']
D056926:CLOCK Proteins D057906:Circadian Clocks D002940:Circadian Rhythm D004040:Dietary Carbohydrates D004041:Dietary Fats D004044:Dietary Proteins D005502:Food D005786:Gene Expression Regulation D051246:Glucose Transport Proteins, Facilitative D006801:Humans D007408:Intestinal Absorption D050356:Lipid Metabolism D026901:Membrane Transport Proteins
circadian rhythms clock genes glucose transporters lipid absorption peptide transporters