Interferon-I: The Pièce de Résistance of HIV-1 Transmission?
Despite the extensive viral quasispecies that develops in an individual during the course of HIV-1 infection, transmission is typically established by a single donor viral variant. Recent studies now provide insight into the phenotypic properties influencing this selection process at transmission, including the contribution of resistance to type I interferons.
['Tully|Damien C|DC|', 'Claiborne|Daniel T|DT|', 'Allen|Todd M|TM|']
D014644:Genetic Variation D015658:HIV Infections D015497:HIV-1 D006801:Humans D007370:Interferon Type I D009092:Mucous Membrane D010802:Phylogeny D012641:Selection, Genetic
Transmission Resistance Interferon Bottleneck HIV Mucosal