TEAD2 as a novel prognostic factor for hepatocellular carcinoma.
TEA Domain Transcription Factors (TEADs) are important in development and serve essential roles in tumorigenesis; however, the role of TEAD2 expression in hepatocellular carcinoma (HCC) has not been widely examined. The present study was conducted to investigate the expression status of TEAD2 in HCC and to evaluate whether the expression of TEAD2 is associated with the prognosis of patients with HCC. mRNA expression data was retrieved for Hippo pathway genes of 50 normal control and 377 HCC samples from The Cancer Genome Atlas data portal. Gene set enrichment, GeneNeighbors, ClassNeighbors and survival analyses were then performed based on the gene expression levels. The mRNA expression of TEAD2 and VGLL4 was significantly higher in HCC compared with the normal control samples, and the mRNA expression of TEAD2 was higher in advanced stages than in early stages. Specifically, survival analysis revealed that higher mRNA expression of TEAD2 was significantly associated with a less favorable overall survival rate (P=0.0067) and there was a trend towards significance between higher mRNA expression of VGLL4 and poor overall survival rate (P=0.051). According to the gene set enrichment analysis, patients with higher mRNA expression of TEAD2 and VGLL4 had strongly enhanced epithelial‑mesenchymal transition and angiogenesis, which are associated with tumor progression. In conclusion, increased mRNA expression of TEAD2 is associated with a poor prognosis in patients with HCC. TEAD2 may serve as a prognostic factor for HCC and a novel therapeutic target.
['Joo|Jong Seok|JS|', 'Cho|Sang Yeon|SY|', 'Rou|Woo Sun|WS|', 'Kim|Ju Seok|JS|', 'Kang|Sun Hyung|SH|', 'Lee|Eaum Seok|ES|', 'Moon|Hee Seok|HS|', 'Kim|Seok Hyun|SH|', 'Sung|Jae Kyu|JK|', 'Kwon|In Sun|IS|', 'Eun|Hyuk Soo|HS|', 'Lee|Byung Seok|BS|']
D000293:Adolescent D000328:Adult D000368:Aged D017209:Apoptosis D014408:Biomarkers, Tumor D006528:Carcinoma, Hepatocellular D016022:Case-Control Studies D002465:Cell Movement D049109:Cell Proliferation D002471:Cell Transformation, Neoplastic D004268:DNA-Binding Proteins D018450:Disease Progression D005260:Female D005500:Follow-Up Studies D020869:Gene Expression Profiling D006801:Humans D008113:Liver Neoplasms D008297:Male D008875:Middle Aged D011379:Prognosis D012189:Retrospective Studies D015996:Survival Rate D000091262:TEA Domain Transcription Factors D014157:Transcription Factors D014407:Tumor Cells, Cultured D055815:Young Adult
TEAD2 hepatocellular carcinoma prognosis The Cancer Genome Atlas data survival analysis