Amides and neolignans from the aerial parts of Piper bonii.
Six amides, piperbonamides A-F, three neolignans piperbonins A-C, and 11 known compounds were isolated from the aerial parts of Piper bonii (Piperaceae). The structures of piperbonamides A-F and piperbonins A-C were elucidated based on the analysis of 1D and 2D NMR and MS data. Piperbonin A, (+)-trans-acuminatin, (+)-cis-acuminatin, (+)-kadsurenone, and pipernonaline showed weak activity against platelet aggregation with IC50 values of 118.2, 108.5, 90.02, 107.3, and 116.3 μM, respectively, as compared with the positive control, tirofiban, with an IC50 value of 5.24 μM. Piperbonamides A-F were inactive against five tumor cell lines at concentrations up to 40 μM.
['Ding|Duo-Duo|DD|', 'Wang|Yue-Hu|YH|', 'Chen|Ya-Hui|YH|', 'Mei|Ren-Qiang|RQ|', 'Yang|Jun|J|', 'Luo|Ji-Feng|JF|', 'Li|Yan|Y|', 'Long|Chun-Lin|CL|', 'Kong|Yi|Y|']
D000470:Alkaloids D000577:Amides D001572:Benzofurans D004305:Dose-Response Relationship, Drug D004354:Drug Screening Assays, Antitumor D005419:Flavonoids D006027:Glycosides D006801:Humans D020128:Inhibitory Concentration 50 D017705:Lignans D015394:Molecular Structure D031701:Piper D010880:Piperidines D035261:Plant Components, Aerial D010974:Platelet Aggregation D010975:Platelet Aggregation Inhibitors D013329:Structure-Activity Relationship D000077466:Tirofiban D014443:Tyrosine
Amides Neolignans Piper bonii Piperaceae Antiplatelet