Long non-coding RNA HOTAIR acts as a competing endogenous RNA to promote glioma progression by sponging miR-126-5p.
LncRNA HOX transcript antisense intergenic RNA (HOTAIR) has been shown to play prominent roles in tumorigenesis. However, its precise molecular mechanism in glioma has not been completely elucidated. In this study, we found that HOTAIR was aberrantly up-regulated in glioma tissues and was negatively correlated with miR-126-5p expression. Next, we determined that HOTAIR promote glioma progression by sponging miR-126-5p. Subsequently, glutaminase (GLS) was confirmed to be a direct target of miR-126-5p using bioinformatics software and a luciferase reporter assay. Moreover, HOTAIR could modulate GLS expression by functioning as a competing endogenous RNA (ceRNA) for miR-126-5p. Taken together, our study clarified that the HOTAIR/miR-126/GLS pathway is involved in glioma progression and may potentially serve as a target for glioma therapy.
['Liu|Liang|L|', 'Cui|Sitong|S|', 'Wan|Teng|T|', 'Li|Xiaojian|X|', 'Tian|Wei|W|', 'Zhang|Rui|R|', 'Luo|Liangsheng|L|0000-0002-6091-1944', 'Shi|Yan|Y|']
D000818:Animals D063646:Carcinogenesis D045744:Cell Line, Tumor D018450:Disease Progression D015972:Gene Expression Regulation, Neoplastic D005910:Glioma D005972:Glutaminase D006801:Humans D008297:Male D051379:Mice D008819:Mice, Nude D035683:MicroRNAs D062085:RNA, Long Noncoding D015854:Up-Regulation
HOTAIR glioma MiR-126-5p GLS ceRNA glutamine metabolism