Cellular senescence in dental pulp stem cells.
OBJECTIVE
This short review summarizes our current knowledge about dental stem cell aging and about possible targets for the regulation of cellular senescence.


DESIGN
A literature search was performed using a combination of keywords, e.g., stem cells, replicative senescence, differentiation potential, dental pulp, dental follicle and periodontal ligament.


RESULTS
Previous studies have shown that cellular senescence occurs while the proliferation of dental stem cells. Moreover, the differentiation potential was significantly decreased in senescent stem cells and senescent cells secrete also factors that are harmful to the adjacent tissue cells. Moreover, many targets for the regulation of cellular senescence are considered; for example pathways related to the nutrient sensing such as the 5' adenosine monophosphate-activated protein kinase (AMPK) pathway.


CONCLUSIONS
The regulation of cellular senescence will play a crucial role in the clinical use of stem cells. However, there is no cell culture protocol available that prevents dental stem cell senescence. Therefore, more knowledge about molecular processes in stem cells is needed before and after the induction of senescence.
['Morsczeck|Christian|C|']
D000091162:AMP-Activated Protein Kinase Kinases D000375:Aging D002454:Cell Differentiation D049109:Cell Proliferation D016922:Cellular Senescence D003782:Dental Pulp D003795:Dental Sac D000078622:Nutrients D009805:Odontogenesis D011494:Protein Kinases D013234:Stem Cells
Cellular senescence Dental pulp stem cells AMPK Odontogenic differentiation SIRT