Artillery
While it is difficult to confirm the use of firearms in the siege of the city, it is known the Portuguese defended it thereafter with firearms, namely bombardas, colebratas, and falconetes. In 1419, Sultan Abu Sa'id led an army to reconquer the fallen city, and Marinids brought cannons and used them in the assault on Ceuta. Finally, hand-held firearms and riflemen appear in Morocco, in 1437, in an expedition against the people of Tangiers. It is clear these weapons had developed into several different forms, from small guns to large artillery pieces.
The artillery revolution in Europe caught on during the Hundred Years' War and changed the way that battles were fought. In the preceding decades, the English had even used a gunpowder-like weapon in military campaigns against the Scottish. However, at this time, the cannons used in battle were very small and not particularly powerful. Cannons were only useful for the defense of a castle, as demonstrated at Breteuil in 1356, when the besieged English used a cannon to destroy an attacking French assault tower. By the end of the 14th century, cannon were only powerful enough to knock in roofs, and could not penetrate castle walls.
However, a major change occurred between 1420 and 1430, when artillery became much more powerful and could now batter strongholds and fortresses quite efficiently. The English, French, and Burgundians all advanced in military technology, and as a result the traditional advantage that went to the defense in a siege was lost. The cannon during this period were elongated, and the recipe for gunpowder was improved to make it three times as powerful as before. These changes led to the increased power in the artillery weapons of the time.

Joan of Arc encountered gunpowder weaponry several times. When she led the French against the English at the Battle of Tourelles, in 1430, she faced heavy gunpowder fortifications, and yet her troops prevailed in that battle. In addition, she led assaults against the English-held towns of Jargeau, Meung, and Beaugency, all with the support of large artillery units. When she led the assault on Paris, Joan faced stiff artillery fire, especially from the suburb of St. Denis, which ultimately led to her defeat in this battle. In April 1430, she went to battle against the Burgundians, whose support was purchased by the English. At this time, the Burgundians had the strongest and largest gunpowder arsenal among the European powers, and yet the French, under Joan of Arc's leadership, were able to beat back the Burgundians and defend themselves. As a result, most of the battles of the Hundred Years' War that Joan of Arc participated in were fought with gunpowder artillery.

The army of Mehmet the Conqueror, which conquered Constantinople in 1453, included both artillery and foot soldiers armed with gunpowder weapons. The Ottomans brought to the siege sixty-nine guns in fifteen separate batteries and trained them at the walls of the city. The barrage of Ottoman cannon fire lasted forty days, and they are estimated to have fired 19,320 times. Artillery also played a decisive role in the Battle of St. Jakob an der Birs of 1444.  Early cannon were not always reliable; King James II of Scotland was killed by the accidental explosion of one of his own cannon, imported from Flanders, at the siege of Roxburgh Castle in 1460.
The able use of artillery supported to a large measure the expansion and defense of the Portuguese Empire, as it was a necessary tool that allowed the Portuguese to face overwhelming odds both on land and sea from Morocco to Asia. In great sieges and in sea battles, the Portuguese demonstrated a level of proficiency in the use of artillery after the beginning of the 16th century unequalled by contemporary European neighbours, in part due to the experience gained in intense fighting in Morocco, which served as a proving ground for artillery and its practical application, and made Portugal a forerunner in gunnery for decades. During the reign of King Manuel (1495–1521) at least 2017 cannon were sent to Morocco for garrison defense, with more than 3000 cannon estimated to have been required during that 26-year period. An especially noticeable division between siege guns and anti-personnel guns enhanced the use and effectiveness of Portuguese firearms above contemporary powers, making cannon the most essential element in the Portuguese arsenal.

The three major classes of Portuguese artillery were anti-personnel guns with a high borelength (including: rebrodequim, berço, falconete, falcão, sacre, áspide, cão, serpentina and passavolante); bastion guns which could batter fortifications (camelete, leão, pelicano, basilisco, águia, camelo, roqueira, urso); and howitzers that fired large stone cannonballs in an elevated arch, weighted up to 4000 pounds and could fire incendiary devices, such as a hollow iron ball filled with pitch and fuse, designed to be fired at close range and burst on contact. The most popular in Portuguese arsenals was the berço, a 5 cm, one pounder bronze breech-loading cannon that weighted 150 kg with an effective range of 600 meters.
A tactical innovation the Portuguese introduced in fort defense was the use of combinations of projectiles against massed assaults. Although canister shot had been developed in the early 15th century, the Portuguese were the first to employ it extensively, and Portuguese engineers invented a canister round which consisted of a thin lead case filled with iron pellets, that broke up at the muzzle and scattered its contents in a narrow pattern. An innovation which Portugal adopted in advance of other European powers was fuse-delayed action shells, and were commonly used in 1505. Although dangerous, their effectiveness meant a sixth of all rounds used by the Portuguese in Morocco were of the fused-shell variety.

The new Ming Dynasty established the "Divine Engine Battalion" (神机营), which specialized in various types of artillery. Light cannons and cannons with multiple volleys were developed. In a campaign to suppress a local minority rebellion near today's Burmese border, "the Ming army used a 3-line method of arquebuses/muskets to destroy an elephant formation".
When the Portuguese and Spanish arrived at Southeast Asia, they found that the local kingdoms were already using cannons. Portuguese and Spanish invaders were unpleasantly surprised and even outgunned on occasion. Duarte Barbosa ca. 1514 said that the inhabitants of Java were great masters in casting artillery and very good artillerymen. They made many one-pounder cannons (cetbang or rentaka), long muskets, spingarde (arquebus), schioppi (hand cannon), Greek fire, guns (cannons), and other fire-works. In all aspects the Javanese were considered excellent in casting artillery, and in the knowledge of using it.: 254 : 198 : 224  In 1513, the Javanese fleet led by Pati Unus sailed to attack Portuguese Malacca "with much artillery made in Java, for the Javanese are skilled in founding and casting, and in all works in iron, over and above what they have in India".: 162 : 23  By the early 16th century, the Javanese already locally-producing large guns, some of them still survived until the present day and dubbed as "sacred cannon" or "holy cannon".  These cannons varied between 180 and 260 pounders, weighing anywhere between 3–8 tons, measuring between 3–6 m.
Between 1593 and 1597, about 200,000 Korean and Chinese troops which fought against Japan in Korea actively used heavy artillery in both siege and field combat. Korean forces mounted artillery in ships as naval guns, providing an advantage against Japanese navy which used Kunikuzushi (国崩し – Japanese breech-loading swivel gun) and Ōzutsu (大筒 – large size Tanegashima) as their largest firearms.

Smoothbores: Bombards were of value mainly in sieges. A famous Turkish example used at the siege of Constantinople in 1453 weighed 19 tons, took 200 men and sixty oxen to emplace, and could fire just seven times a day. The Fall of Constantinople was perhaps "the first event of supreme importance whose result was determined by the use of artillery" when the huge bronze cannons of Mehmed II breached the city's walls, ending the Byzantine Empire, according to Sir Charles Oman.
Bombards developed in Europe were massive smoothbore weapons distinguished by their lack of a field carriage, immobility once emplaced, highly individual design, and noted unreliability (in 1460 James II, King of Scots, was killed when one exploded at the siege of Roxburgh). Their large size precluded the barrels being cast and they were constructed out of metal staves or rods bound together with hoops like a barrel, giving their name to the gun barrel.
The use of the word "cannon" marks the introduction in the 15th century of a dedicated field carriage with axle, trail and animal-drawn limber—this produced mobile field pieces that could move and support an army in action, rather than being found only in the siege and static defenses.