His uncle Alfonso de Borgia, bishop of Valencia, guided his nephew’s education and saw to it that while still in his teens, Rodrigo was endowed with ecclesiastical benefices (ecclesiastical offices with revenue attached).
Aizbildniecību par Rodrigo izglītošanu uzņēmās viņa tēvocis, Valensijas bīskaps Alfonso de Bordža. Tēvocis parūpējās, lai māsasdēls jau pusaudža gados tiktu iecelts ienesīgos baznīcas amatos.