Chronic disease may also cause RLS symptoms — particularly kidney failure, diabetes, rheumatoid arthritis, and peripheral neuropathy, damage to the nerves in the hands and the feet.
Penyakit kronis juga dapat menyebabkan gejala RLS ​ — khususnya gagal ginjal, diabetes, artritis rematoid, dan neuropati periferal, merusak susunan saraf pada tangan dan kaki.