The city reached particular prominence during the reign of the last Macedonian dynasty, the Antigonids (306 - 168 B.C.E.), who were eventually overthrown by Rome.
Kota itu mencapai puncak kejayaannya selama pemerintahan dinasti Makedonia yang terakhir, Antigonus, (306 - 168 SM), yang akhirnya ditaklukkan Roma.