The most serious form is called diffuse or systemic and is characterized by rapid development of a thickening of the skin, beginning with the hands and face and extending to the arms and trunk.
والمصابون بتصلُّب الجلد المنتشر هم في خطر اكبر ان تُصاب اعضاؤهم الداخلية في مرحلة باكرة من المرض .‏