Australian Aborigines and Native Americans are among the most affected, the latter having the highest rate of Type 2 diabetes in the world.
जिवाणू, विषारी रसायने व विशिष्ट औषधांमुळे रोगप्रतिकारक शक्‍तीची प्रतिक्रिया प्रवृत्त होऊ शकते.