In 1909, Carlos Chagas, a Brazilian doctor, was working in Minas Gerais State, Brazil, where malaria was hindering the construction of a railroad.
त्यांच्या लक्षात आले की बऱ्‍याच रोग्यांमध्ये वेगळ्याच प्रकारची लक्षणे दिसत होती.