<sod>The ketogenic diet may be a successful treatment for several rare metabolic diseases, such as [[De_Vivo_disease|Glut1 deficiency syndrome]]. Case reports of two children indicate that it may be a possible treatment for [[astrocytoma]]s, a type of brain tumour. [[Autism spectrum|Autism]], [[major depressive disorder|depression]], [[migraine]] headaches, [[polycystic ovary syndrome]] and [[diabetes mellitus type 2]] have also been shown to improve in small case studies.<ref name=Hartman2007b/> There is evidence from uncontrolled clinical trials and studies in animal models that the ketogenic diet can provide symptomatic and disease-modifying activity in a broad range of neurodegenerative disorders including [[amyotrophic lateral sclerosis]], [[Alzheimer's disease]] and [[Parkinson's disease]],<ref name=Hartman2007b/><ref name=Paoli2014/> and may be protective in [[traumatic brain injury]] and [[stroke]].<ref name=Gasior2006/><ref name=Maalouf2009/><eod>
<sod>The ketogenic diet may be a successful treatment for several rare metabolic diseases. Case reports of two children indicate that it may be a possible treatment for [[astrocytoma]]s, a type of brain tumour. [[Autism spectrum|Autism]], [[major depressive disorder|depression]], [[migraine]] headaches, [[polycystic ovary syndrome]] and [[diabetes mellitus type 2]] have also been shown to improve in small case studies.<ref name=Hartman2007b/> There is evidence from uncontrolled clinical trials and studies in animal models that the ketogenic diet can provide symptomatic and disease-modifying activity in a broad range of neurodegenerative disorders including [[amyotrophic lateral sclerosis]], [[Alzheimer's disease]] and [[Parkinson's disease]],<ref name=Hartman2007b/><ref name=Paoli2014/> and may be protective in [[traumatic brain injury]] and [[stroke]].<ref name=Gasior2006/><ref name=Maalouf2009/><eod>