<sod>'''DNA-dependent protein kinase, catalytic subunit''', also known as '''DNA-PKcs''', is an [[enzyme]] that in humans is encoded by the ''PRKDC'' [[gene]].<ref name="pmid7638222">{{cite journal | author = Sipley JD, Menninger JC, Hartley KO, Ward DC, Jackson SP, Anderson CW | title = Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 16 | pages = 7515–9 |date=August 1995 | pmid = 7638222 | pmc = 41370 | doi = 10.1073/pnas.92.16.7515| url = | issn = }}</ref> DNA-PKcs belongs to the [[phosphatidylinositol 3-kinase-related kinase]] protein family.<eod>
<sod>'''DNA-dependent protein kinase, catalytic subunit''', also known as '''DNA-PKcs''', is an [[enzyme]] that in humans is encoded by the ''PRKDC'' [[gene]].<ref name="pmid7638222">{{cite journal | author = Sipley JD, Menninger JC, Hartley KO, Ward DC, Jackson SP, Anderson CW | title = Gene for the catalytic subunit of the human DNA-activated protein kinase maps to the site of the XRCC7 gene on chromosome 8 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 16 | pages = 7515–9 |date=August 1995 | pmid = 7638222 | pmc = 41370 | doi = 10.1073/pnas.92.16.7515| url = | issn = }}</ref> DNA-PKcs belongs to the [[phosphatidylinositol 3-kinase-related kinase]] protein family. The DNA-Pkcs protein is a serine/threonine protein kinase comprising a single polypeptide chain of 4,128 amino acids.<ref name="pmid20023628">{{cite journal |vauthors=Sibanda BL, Chirgadze DY, Blundell TL |title=Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats |journal=Nature |volume=463 |issue=7277 |pages=118–21 |year=2010 |pmid=20023628 |pmc=2811870 |doi=10.1038/nature08648 |url=}}</ref><ref name="pmid7671312">{{cite journal |vauthors=Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, Admon A, Lees-Miller SP, Anderson CW, Jackson SP |title=DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product |journal=Cell |volume=82 |issue=5 |pages=849–56 |year=1995 |pmid=7671312 |doi= |url=}}</ref><eod>