<sod >He said "window of opportunity has been lost" to help Charlie, as it is best to act as early as possible to treatÃÂ mitochondrial disease.< eod>< sod > ÃÂ  He said a "window of opportunity has been lost" to help Charlie, as the damage meant Ã¢ÂÂthe treatment can no longer be a successÃ¢ÂÂ.< eod>