<sod>There are three main types of anemia: that due to [[blood loss]], that due to decreased red blood cell production and that due to increased red blood cell breakdown.<!-- <ref name=EBM2013 /> --> Causes of blood loss include [[Injury|trauma]] and [[gastrointestinal bleeding]], among others.<!-- <ref name=EBM2013 /> --> Causes of decreased production include [[iron deficiency]], a [[vitamin B12 deficiency|lack of vitamin B12]], [[thalassemia]], and a number of [[neoplasms of the bone marrow]].<!-- <ref name=EBM2013 /> --> Causes of increased breakdown include a number of genetic conditions such as [[sickle cell anemia]], infections like [[malaria]], and certain autoimmune diseases.<!-- <ref name=EBM2013 /> --> It can also be classified based on the [[mean corpuscular volume|size of red blood cells]] and [[mean corpuscular hemoglobin|amount of hemoglobin in each cell]].<!-- <ref name=EBM2013 /> --> If the cells are small, it is [[microcytic anemia]].<!-- <ref name=EBM2013 /> --> If they are large, it is [[macrocytic anemia]] while if they are normal sized, it is [[normocytic anemia]].<!-- <ref name=EBM2013 /> --> Diagnosis in men is based on a hemoglobin of less than 130 to 140&nbsp;g/L (13 to 14&nbsp;g/dL), while in women, it must be less than 120 to 130&nbsp;g/L (12 to 13&nbsp;g/dL).<ref name=EBM2013 /><ref name=Smith2010>{{cite journal|last1=Smith RE|first1=Jr|title=The clinical and economic burden of anemia.|journal=The American journal of managed care|date=Mar 2010|volume=16 Suppl Issues|pages=S59-66|pmid=20297873}}</ref> Further testing is then required to determine the cause.<ref name=EBM2013 /><eod>
<sod>There are four main types of anemia: that due to [[blood loss]], that due to decreased red blood cell production, that during pregnancy in which the increase of plasm outpaces the increase of RBCs, and that due to increased red blood cell breakdown.<!-- <ref name=EBM2013 /> --> Causes of blood loss include [[Injury|trauma]] and [[gastrointestinal bleeding]], among others.<!-- <ref name=EBM2013 /> --> Causes of decreased production include [[iron deficiency]], a [[vitamin B12 deficiency|lack of vitamin B12]], [[thalassemia]], and a number of [[neoplasms of the bone marrow]].<!-- <ref name=EBM2013 /> --> Causes of increased breakdown include a number of genetic conditions such as [[sickle cell anemia]], infections like [[malaria]], and certain autoimmune diseases.<!-- <ref name=EBM2013 /> --> It can also be classified based on the [[mean corpuscular volume|size of red blood cells]] and [[mean corpuscular hemoglobin|amount of hemoglobin in each cell]].<!-- <ref name=EBM2013 /> --> If the cells are small, it is [[microcytic anemia]].<!-- <ref name=EBM2013 /> --> If they are large, it is [[macrocytic anemia]] while if they are normal sized, it is [[normocytic anemia]].<!-- <ref name=EBM2013 /> --> Diagnosis in men is based on a hemoglobin of less than 130 to 140&nbsp;g/L (13 to 14&nbsp;g/dL), while in women, it must be less than 120 to 130&nbsp;g/L (12 to 13&nbsp;g/dL).<ref name=EBM2013 /><ref name=Smith2010>{{cite journal|last1=Smith RE|first1=Jr|title=The clinical and economic burden of anemia.|journal=The American journal of managed care|date=Mar 2010|volume=16 Suppl Issues|pages=S59-66|pmid=20297873}}</ref> Further testing is then required to determine the cause.<ref name=EBM2013 /><eod>