<sod>'''Quorum-quenching N-acyl-homoserine lactonase''' ({{EC number|3.1.1.81}}, ''acyl homoserine degrading enzyme'', ''acyl-homoserine lactone acylase'', ''AHL lactonase'', ''AHL-degrading enzyme'', ''AHL-inactivating enzyme'', ''AHLase'', ''AhlD'', ''AhlK'', ''AiiA'', ''AiiA lactonase'', ''AiiA-like protein'', ''AiiB'', ''AiiC'', ''AttM'', ''delactonase'', ''lactonase-like enzyme'', ''N-acyl homoserine lactonase'', ''N-acyl homoserine lactone hydrolase'', ''N-acyl-homoserine lactone lactonase'', ''N-acyl-L-homoserine lactone hydrolase'', ''quorum-quenching lactonase'', ''quorum-quenching N-acyl homoserine lactone hydrolase'') is an [[enzyme]] with system name ''N-acyl-L-homoserine-lactone lactonohydrolase''.<ref>{{cite journal | title = The quorum-quenching lactonase from ''Bacillus thuringiensis'' is a metalloprotein |author = Thomas, P.W., Stone, E.M., Costello, A.L., Tierney, D.L. and Fast, W. |journal = Biochemistry |year = 2005 |volume = 44 |pages = 7559–7569 |pmid = 15895999 |doi=10.1021/bi050050m}}</ref><ref>{{cite journal | title = Identification of quorum-quenching ''N''-acyl homoserine lactonases from ''Bacillus'' species |author = Dong, Y.H., Gusti, A.R., Zhang, Q., Xu, J.L. and Zhang, L.H. |journal = Appl. Environ. Microbiol. |year = 2002 |volume = 68 |pages = 1754–1759 |pmid = 11916693 |doi=10.1128/AEM.68.4.1754-1759.2002 |pmc=123891}}</ref><ref>{{cite journal | title = Specificity and enzyme kinetics of the quorum-quenching ''N''-acyl homoserine lactone lactonase (AHL-lactonase) |author = Wang, L.H., Weng, L.X., Dong, Y.H. and Zhang, L.H. |journal = J. Biol. Chem. |year = 2004 |volume = 279 |pages = 13645–13651 |pmid = 14734559 |doi=10.1074/jbc.M311194200 |issue=14}}</ref><ref>{{cite journal | title = AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of ''Erwinia carotovora'' |author = Dong, Y.H., Xu, J.L., Li, X.Z. and Zhang, L.H. |journal = Proc. Natl. Acad. Sci. USA |year = 2000 |volume = 97 |pages = 3526–3531 |pmid = 10716724 |doi=10.1073/pnas.060023897 |issue=7}}</ref><ref>{{cite journal | title = Quenching quorum-sensing-dependent bacterial infection by an ''N''-acyl homoserine lactonase |author = Dong, Y.H., Wang, L.H., Xu, J.L., Zhang, H.B., Zhang, X.F. and Zhang, L.H. |journal = Nature |year = 2001 |volume = 411 |pages = 813–817 |pmid = 11459062 |doi=10.1038/35081101}}</ref><ref>{{cite journal | title = Genes encoding the ''N''-acyl homoserine lactone-degrading enzyme are widespread in many subspecies of ''Bacillus thuringiensis'' |author = Lee, S.J., Park, S.Y., Lee, J.J., Yum, D.Y., Koo, B.T. and Lee, J.K. |journal = Appl. Environ. Microbiol. |year = 2002 |volume = 68 |pages = 3919–3924 |pmid = 12147491 |issue=8 |doi=10.1128/aem.68.8.3919-3924.2002}}</ref><ref>{{cite journal | title = AhlD, an ''N''-acylhomoserine lactonase in ''Arthrobacter sp''., and predicted homologues in other bacteria |author = Park, S.Y., Lee, S.J., Oh, T.K., Oh, J.W., Koo, B.T., Yum, D.Y. and Lee, J.K. |journal = Microbiology |year = 2003 |volume = 149 |pages = 1541–1550 |pmid = 12777494 |issue=Pt 6 |doi=10.1099/mic.0.26269-0}}</ref><ref>{{cite journal | title = Quorum quenching: enzymatic disruption of ''N''-acylhomoserine lactone-mediated bacterial communication in ''Burkholderia thailandensis'' |author = Ulrich, R.L. |journal = Appl. Environ. Microbiol. |year = 2004 |volume = 70 |pages = 6173–6180 |pmid = 15466564 |doi=10.1128/AEM.70.10.6173-6180.2004 |issue=10}}</ref><ref>{{cite journal | title = The molecular structure and catalytic mechanism of a quorum-quenching ''N''-acyl-L-homoserine lactone hydrolase |author = Kim, M.H., Choi, W.C., Kang, H.O., Lee, J.S., Kang, B.S., Kim, K.J., Derewenda, Z.S., Oh, T.K., Lee, C.H. and Lee, J.K. |journal = Proc. Natl. Acad. Sci. USA |year = 2005 |volume = 102 |pages = 17606–17611 |pmid = 16314577 |doi=10.1073/pnas.0504996102 |issue=49}}</ref><ref>{{cite journal | title = Three-dimensional structure of the quorum-quenching ''N''-acyl homoserine lactone hydrolase from ''Bacillus thuringiensis'' |author = Liu, D., Lepore, B.W., Petsko, G.A., Thomas, P.W., Stone, E.M., Fast, W. and Ringe, D. |journal = Proc. Natl. Acad. Sci. USA |year = 2005 |volume = 102 |pages = 11882–11887 |pmid = 16087890 |doi=10.1073/pnas.0505255102 |issue=33}}</ref><ref>{{cite journal | title = Quorum quenching enzyme activity is widely conserved in the sera of mammalian species |author = Yang, F., Wang, L.H., Wang, J., Dong, Y.H., Hu, J.Y. and Zhang, L.H. |journal = FEBS Lett. |year = 2005 |volume = 579 |pages = 3713–3717 |pmid = 15963993 |doi=10.1016/j.febslet.2005.05.060 |issue=17}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]<eod>
<sod>'''Quorum-quenching N-acyl-homoserine lactonase''' ({{EC number|3.1.1.81}}, ''acyl homoserine degrading enzyme'', ''acyl-homoserine lactone acylase'', ''AHL lactonase'', ''AHL-degrading enzyme'', ''AHL-inactivating enzyme'', ''AHLase'', ''AhlD'', ''AhlK'', ''AiiA'', ''AiiA lactonase'', ''AiiA-like protein'', ''AiiB'', ''AiiC'', ''AttM'', ''delactonase'', ''lactonase-like enzyme'', ''N-acyl homoserine lactonase'', ''N-acyl homoserine lactone hydrolase'', ''N-acyl-homoserine lactone lactonase'', ''N-acyl-L-homoserine lactone hydrolase'', ''quorum-quenching lactonase'', ''quorum-quenching N-acyl homoserine lactone hydrolase'') is an [[enzyme]] with systematic name ''N-acyl-L-homoserine-lactone lactonohydrolase''.<ref>{{cite journal | title = The quorum-quenching lactonase from ''Bacillus thuringiensis'' is a metalloprotein |author = Thomas, P.W., Stone, E.M., Costello, A.L., Tierney, D.L. and Fast, W. |journal = Biochemistry |year = 2005 |volume = 44 |pages = 7559–7569 |pmid = 15895999 |doi=10.1021/bi050050m}}</ref><ref>{{cite journal | title = Identification of quorum-quenching ''N''-acyl homoserine lactonases from ''Bacillus'' species |author = Dong, Y.H., Gusti, A.R., Zhang, Q., Xu, J.L. and Zhang, L.H. |journal = Appl. Environ. Microbiol. |year = 2002 |volume = 68 |pages = 1754–1759 |pmid = 11916693 |doi=10.1128/AEM.68.4.1754-1759.2002 |pmc=123891}}</ref><ref>{{cite journal | title = Specificity and enzyme kinetics of the quorum-quenching ''N''-acyl homoserine lactone lactonase (AHL-lactonase) |author = Wang, L.H., Weng, L.X., Dong, Y.H. and Zhang, L.H. |journal = J. Biol. Chem. |year = 2004 |volume = 279 |pages = 13645–13651 |pmid = 14734559 |doi=10.1074/jbc.M311194200 |issue=14}}</ref><ref>{{cite journal | title = AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of ''Erwinia carotovora'' |author = Dong, Y.H., Xu, J.L., Li, X.Z. and Zhang, L.H. |journal = Proc. Natl. Acad. Sci. USA |year = 2000 |volume = 97 |pages = 3526–3531 |pmid = 10716724 |doi=10.1073/pnas.060023897 |issue=7}}</ref><ref>{{cite journal | title = Quenching quorum-sensing-dependent bacterial infection by an ''N''-acyl homoserine lactonase |author = Dong, Y.H., Wang, L.H., Xu, J.L., Zhang, H.B., Zhang, X.F. and Zhang, L.H. |journal = Nature |year = 2001 |volume = 411 |pages = 813–817 |pmid = 11459062 |doi=10.1038/35081101}}</ref><ref>{{cite journal | title = Genes encoding the ''N''-acyl homoserine lactone-degrading enzyme are widespread in many subspecies of ''Bacillus thuringiensis'' |author = Lee, S.J., Park, S.Y., Lee, J.J., Yum, D.Y., Koo, B.T. and Lee, J.K. |journal = Appl. Environ. Microbiol. |year = 2002 |volume = 68 |pages = 3919–3924 |pmid = 12147491 |issue=8 |doi=10.1128/aem.68.8.3919-3924.2002}}</ref><ref>{{cite journal | title = AhlD, an ''N''-acylhomoserine lactonase in ''Arthrobacter sp''., and predicted homologues in other bacteria |author = Park, S.Y., Lee, S.J., Oh, T.K., Oh, J.W., Koo, B.T., Yum, D.Y. and Lee, J.K. |journal = Microbiology |year = 2003 |volume = 149 |pages = 1541–1550 |pmid = 12777494 |issue=Pt 6 |doi=10.1099/mic.0.26269-0}}</ref><ref>{{cite journal | title = Quorum quenching: enzymatic disruption of ''N''-acylhomoserine lactone-mediated bacterial communication in ''Burkholderia thailandensis'' |author = Ulrich, R.L. |journal = Appl. Environ. Microbiol. |year = 2004 |volume = 70 |pages = 6173–6180 |pmid = 15466564 |doi=10.1128/AEM.70.10.6173-6180.2004 |issue=10}}</ref><ref>{{cite journal | title = The molecular structure and catalytic mechanism of a quorum-quenching ''N''-acyl-L-homoserine lactone hydrolase |author = Kim, M.H., Choi, W.C., Kang, H.O., Lee, J.S., Kang, B.S., Kim, K.J., Derewenda, Z.S., Oh, T.K., Lee, C.H. and Lee, J.K. |journal = Proc. Natl. Acad. Sci. USA |year = 2005 |volume = 102 |pages = 17606–17611 |pmid = 16314577 |doi=10.1073/pnas.0504996102 |issue=49}}</ref><ref>{{cite journal | title = Three-dimensional structure of the quorum-quenching ''N''-acyl homoserine lactone hydrolase from ''Bacillus thuringiensis'' |author = Liu, D., Lepore, B.W., Petsko, G.A., Thomas, P.W., Stone, E.M., Fast, W. and Ringe, D. |journal = Proc. Natl. Acad. Sci. USA |year = 2005 |volume = 102 |pages = 11882–11887 |pmid = 16087890 |doi=10.1073/pnas.0505255102 |issue=33}}</ref><ref>{{cite journal | title = Quorum quenching enzyme activity is widely conserved in the sera of mammalian species |author = Yang, F., Wang, L.H., Wang, J., Dong, Y.H., Hu, J.Y. and Zhang, L.H. |journal = FEBS Lett. |year = 2005 |volume = 579 |pages = 3713–3717 |pmid = 15963993 |doi=10.1016/j.febslet.2005.05.060 |issue=17}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]<eod>