<sod>'''Coeliac disease''', also spelled '''celiac disease''', is an [[autoimmune disorder]] affecting primarily the [[small intestine]] that occurs in people who are [[Genetic predisposition|genetically predisposed]].<ref name=NIH2015>{{cite web|title=Celiac Disease|url=http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/celiac-disease/Pages/facts.aspx|website=NIDDKD|accessdate=17 March 2016|date = June 2015}}</ref> Classic symptoms include gastrointestinal problems such as chronic [[diarrhea|diarrhoea]], [[abdominal distention]], [[malabsorption]], loss of appetite, and among children [[failure to thrive|failure to grow normally]].<!-- <ref name=Fasano2005Pediatric/> --> This often begins between six months and two years of age.<ref name=Fasano2005Pediatric /> Non-classic symptoms are the most common, especially in people older than two years.<ref name=ESPGHAN2012 /><ref name=RostamiNejadHoggKollars2011>{{cite journal|vauthors=Rostami Nejad M, Hogg-Kollars S, Ishaq S, Rostami K|title= Subclinical celiac disease and gluten sensitivity|journal=Gastroenterol Hepatol Bed Bench |volume=4|issue=3|pages=102–8|date=2011|pmid=24834166|pmc=4017418|doi=|type=Review}}</ref><ref name=TonuttiBizzaro2014>{{cite journal|vauthors=Tonutti E, Bizzaro N|title=Diagnosis and classification of celiac disease and gluten sensitivity|journal=Autoimmun Rev|volume=13|issue=4-5|pages=472–6|date=2014|pmid=24440147|doi=10.1016/j.autrev.2014.01.043|type=Review}}</ref> There may be mild or absent gastrointestinal symptoms, a wide number of [[systemic disease|symptoms involving any part of the body]], or no obvious symptoms.<ref name=Fasano2005Pediatric /><ref name=CiccocioppoKruzliak2015/> Coeliac disease was first described in childhood;<ref name=ESPGHAN2012>{{cite journal|vauthors=Husby S, Koletzko S, Korponay-Szabó IR, Mearin ML, Phillips A, Shamir R, Troncone R, Giersiepen K, Branski D, Catassi C, Lelgeman M, Mäki M, Ribes-Koninckx C, Ventura A, Zimmer KP,(( ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterology Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition)) |title=European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease|journal=J Pediatr Gastroenterol Nutr|volume=54|issue=1|pages=136–60|date=Jan 2012|pmid=22197856|url=http://www.espghan.org/fileadmin/user_upload/guidelines_pdf/Guidelines_2404/European_Society_for_Pediatric_Gastroenterology_.28__1_.pdf|doi=10.1097/MPG.0b013e31821a23d0|type=Practice Guideline|quote=Since 1990, the understanding of the pathological processes of CD has increased enormously, leading to a change in the clinical paradigm of CD from a chronic, gluten-dependent enteropathy of childhood to a systemic disease with chronic immune features affecting different organ  systems. (...) atypical symptoms may be considerably more common than classic symptoms}}</ref><ref name=CiccocioppoKruzliak2015>{{cite journal|vauthors=Ciccocioppo R, Kruzliak P, Cangemi GC, Pohanka M, Betti E, Lauret E, Rodrigo L|title=The Spectrum of Differences between Childhood and Adulthood Celiac Disease|journal=Nutrients|volume=7|issue=10|pages=8733–51|date=Oct 22, 2015|pmid=26506381|pmc=4632446|doi=10.3390/nu7105426|type=Review|quote=Several additional studies in extensive series of celiac patients have clearly shown that TG2A sensitivity varies depending on the severity of duodenal damage, and reaches almost 100% in the presence of complete villous atrophy (more common in children under three years), 70% for subtotal atrophy, and up to 30% when only an increase in IELs is present. ''(IELs: intraepithelial lymphocytes)''}}</ref> however, it may develop at any age.<ref name=Fasano2005Pediatric>{{cite journal|author=Fasano A|title=Clinical presentation of celiac disease in the pediatric population|journal=Gastroenterology|volume=128|issue=4 Suppl 1|pages=S68-73|date=Apr 2005|pmid=15825129|doi=10.1053/j.gastro.2005.02.015|type=Review}}</ref><ref name=ESPGHAN2012 /> It is associated with other [[autoimmune disease]]s, such as [[diabetes mellitus type 1]] and [[thyroiditis]], among others.<ref name=CiccocioppoKruzliak2015 /><eod>
<sod>'''Coeliac disease''', also spelled '''celiac disease''', is an [[autoimmune disorder]] affecting primarily the [[small intestine]] that occurs in people who are [[Genetic predisposition|genetically predisposed]].<ref name=NIH2015>{{cite web|title=Celiac Disease|url=http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/celiac-disease/Pages/facts.aspx|website=NIDDKD|accessdate=17 March 2016|date = June 2015}}</ref> Classic symptoms include gastrointestinal problems such as chronic [[diarrhea|diarrhoea]], [[abdominal distention]], [[malabsorption]], loss of appetite, and among children [[failure to thrive|failure to grow normally]].<!-- <ref name=Fasano2005Pediatric/> --> This often begins between six months and two years of age.<ref name=Fasano2005Pediatric>{{cite journal|author=Fasano A|title=Clinical presentation of celiac disease in the pediatric population|journal=Gastroenterology|volume=128|issue=4 Suppl 1|pages=S68-73|date=Apr 2005|pmid=15825129|doi=10.1053/j.gastro.2005.02.015|type=Review}}</ref> Non-classic symptoms are the most common, especially in people older than two years.<ref name=ESPGHAN2012 /><ref name=RostamiNejadHoggKollars2011>{{cite journal|vauthors=Rostami Nejad M, Hogg-Kollars S, Ishaq S, Rostami K|title= Subclinical celiac disease and gluten sensitivity|journal=Gastroenterol Hepatol Bed Bench |volume=4|issue=3|pages=102–8|date=2011|pmid=24834166|pmc=4017418|doi=|type=Review}}</ref><ref name=TonuttiBizzaro2014>{{cite journal|vauthors=Tonutti E, Bizzaro N|title=Diagnosis and classification of celiac disease and gluten sensitivity|journal=Autoimmun Rev|volume=13|issue=4-5|pages=472–6|date=2014|pmid=24440147|doi=10.1016/j.autrev.2014.01.043|type=Review}}</ref> There may be mild or absent gastrointestinal symptoms, a wide number of [[systemic disease|symptoms involving any part of the body]], or no obvious symptoms.<ref name=Fasano2005Pediatric /> Coeliac disease was first described in childhood;<ref name=ESPGHAN2012>{{cite journal|vauthors=Husby S, Koletzko S, Korponay-Szabó IR, Mearin ML, Phillips A, Shamir R, Troncone R, Giersiepen K, Branski D, Catassi C, Lelgeman M, Mäki M, Ribes-Koninckx C, Ventura A, Zimmer KP,(( ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterology Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition)) |title=European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease|journal=J Pediatr Gastroenterol Nutr|volume=54|issue=1|pages=136–60|date=Jan 2012|pmid=22197856|url=http://www.espghan.org/fileadmin/user_upload/guidelines_pdf/Guidelines_2404/European_Society_for_Pediatric_Gastroenterology_.28__1_.pdf|doi=10.1097/MPG.0b013e31821a23d0|type=Practice Guideline|quote=Since 1990, the understanding of the pathological processes of CD has increased enormously, leading to a change in the clinical paradigm of CD from a chronic, gluten-dependent enteropathy of childhood to a systemic disease with chronic immune features affecting different organ  systems. (...) atypical symptoms may be considerably more common than classic symptoms}}</ref><ref name=ESPGHAN2012 /> It is associated with other [[autoimmune disease]]s, such as [[diabetes mellitus type 1]] and [[thyroiditis]], among others.<eod>