In mammalian mitosis, APCCCdc and APCCCdh are sequentially activated , ,. 유사 분열 미끄러짐은 SAC가 활성화된 상태에서 사이클린 B의 점진적인 분해에 의존합니다. This suggests that APCCCdh, but not APCCCdc, is also involved in mitotic slippage in mammalian cells.