This natural selection process is exacerbated by human factors such as inappropriate use of antimicrobials in human and veterinary medicine, poor hygiene conditions and practices in healthcare settings or in the food chain facilitating the transmission of resistant microorganisms.
Na taj proces prirodnog odabira dodatno utječu ljudski čimbenici, kao što su neodgovarajuća primjena antimikrobnih sredstava u humanoj i veterinarskoj medicini te loši higijenski uvjeti i prakse u okviru zdravstvene skrbi ili u prehrambenom lancu, koji pogoduju prenošenju otpornih mikroorganizama.