CORRECTION OF ALLOSTIMULATORY ACTIVITY IFNA-INDUCED DENDRITIC CELLS IN PATIENTS WITH MALIGNANT LYMPHOMA IN VITRO
We performed a comparative study of the expression of B7-H1 on dendritic cells (DCs) generated in the presence of GM-CSF and IFN-α, in healthy people blood donors (n = 12) and patients with malignant lymphomas (MLs) (n = 8). It is shown that DC patients are characterized by 2-fold increase in expression of B7-H1 (62,5 ± 4,6% vs. 37,3 ± 3,37% of donors, p u <0,05), which is associated with a reduction of allostimulatory activity. Also the paper shows that IL-2 and Panagen can restore the functional activity of DCs of patients with MLs.