The Study of Reparative and Immune Potential of <i>Bacillus Sp</i>. Bacteria from Permafrost
A high reparative potential of Bacillus sp. bacteria is set on the skin wound model. The bacteria have been isolated from permafrost and their metabolic products - metabolites. The most effective are the “thermal” metabolites produced by culturing the bacteria at 37°C. When applied locally to the wound, they optimize the regenerative process: reduce the time of wound contraction, retract a scar tissue, and renew a coat. The ointment with “thermal” metabolites accelerates the repair process by 30% relative to the ointment base, by 20% - relative to the Solkoseril pharmaceutical, and by 10% - relative to the bacteria themselves. The dynamics of the formative processes in the healing of skin defects under the influence of Bacillus sp. bacteria and their metabolites are correlated with the dynamics of the immune system activity. The sequence of changes in the activity of various parts of the immune system (nonspecific immunoresistance-cellular immunity - humoral immunity) corresponds to the phases of the reparation process (damage - inflammation - recovery). Based on these data, Bacillus sp. metabolites can be attributed to the modulators of the reparation process with predominant regeneration mechanisms.