Enteroviruses and acute coronary syndrome
The purpose of this work was to evaluate a role of the enterovirus (EV) infections (Coxsackie, ESNO, Entero) in development of acute coronary syndrome (ACS), and its complications. Detections of EV antigens (EVA) and relative quantities of EVA (RQEA) were examined in blood of patients suffering from unstable angina (UA; 27 patients) uncomplicated myocardial infartion (MI; 48 patients) and MI complicated (133 patients) with arrhythmias pulmonary oedema cardiogenic shock or heart rupture, and 94 postmortem heart tissues samples of patients dying from cardiogenic shock and/or heart ruptures. EVA were detected in blood of 7 % patients with UA, 10 % patients without complications of MI and 32 % patients with complicated MI. RQEA patients with UA (0,21 ± 0,07 units) were significantly lower than in patients with uncomplicated MI (0,29 ± 0,02 units; p p p < 0,000) were significantly higher than RQEA in their normal heart tissues (0,30 ± 0,10 and 0,26 ± 0,10 units). Thus EVs may significantly contribute to the pathogenesis of ACS cardiogenic shock, and heart ruptures in patients with MI.