THE INFLUENCE OF BETA-ADRENOBLOCKERS ON PLASMA LIPID SPECTRUM IN EXPERIMENTAL HEART FAILURE
The character of beta-adrenoblockers’ influence on blood lipid spectrum in heart failure depended on its selectivity for β 1-adrenoreceptors. The most selective drugs nebivolol and metoprolol had a metabolic neutral profile of action, and nebivolol even decreased lipoproteins of very low density concentration. Less selective and especially nonselective beta-adrenoblockers pindolol and propranolol brought down high-density lipoproteins levels increasing atherogenic potential of plasma.