EXPERIMENTAL STUDY OF LABELED WITH TECHNETIUM-99M CIPROFLOXACIN
To conduct an experimental research of the 99mTc-ciprofloxacin. The pharmacokinetics of the 99mTc-ciprofloxacin was studied on 70 white rats after intravenous injection at a dose of 5.3 MBq/kg. Ability of 99mTc-ciprofloxacin to render specific foci of infection inflammation was studied on models of staphylococcal abscess of the right scapula in rabbits (as a comparison group - the rabbits with a model of aseptic inflammation) and acute staphylococcal pneumonia in dogs. The maximum radioactivity of 99mTc-ciprofloxacin in rats after intravenous administration was determined in the bladder and kidneys, which corresponds to the pharmacokinetics of non-labeled antibiotic. Pathological focuses in all rabbits with a model of abscess, as well as in dogs with a model of inflammation in the chest visualized best at 1,5-2 hours after injection of 99mTc-ciprofloxacin. In the comparison group radiopharmaceutical accumulation in the inflammatory infiltrate was not recorded. This study demonstrated the suitability of 99mTc-ciprofloxacin to image infectious inflammation focuses including those located in the chest.