Male and female rats ( 18 / sex / group ) were given COMPOUND_XXX by oral intubation at doses of 0 ( vehicle control ) , 50 , 150 and 500 mg / kg / day .
Male and female rats ( 18 / sex / group ) were given COMPOUND_XXX by oral intubation at doses of 0 ( vehicle control ) , 50 , 150 and 500 mg / kg / day .
O O O O O B-GROUP I-GROUP I-GROUP I-GROUP I-GROUP O O O O O O O O O O B-GROUP I-GROUP I-GROUP I-GROUP I-GROUP O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O