COMPOUND_XXX was administered by dermal skin painting to the dorsal surface ( approximately 10 % of total body surface area ) of CD - 1 mice ( 5 / sex / group ) at dose levels of 100 , 200 or 270 mg / kg for at least 28 days .
COMPOUND_XXX was administered by dermal skin painting to the dorsal surface ( approximately 10 % of total body surface area ) of CD - 1 mice ( 5 / sex / group ) at dose levels of 100 , 200 or 270 mg / kg for at least 28 days .
O O O O O O O O O O O O O O O O O O O O O O O O O O O B-GROUP I-GROUP I-GROUP I-GROUP I-GROUP O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O