At 60 and 600 mg / kg / day , mean jejunal mucosa concentrations of COMPOUND_XXX were slightly to moderately higher at 20:00 , 23:00 and 08:00 than at the other time points , whereas PAG concentrations were generally in a similar range within each group at all time points with the exception of an increased value for the high - dose animals at 05:00 a.m. COMPOUND_XXX plasma concentrations were higher at night and in the early morning ( 23:00 , 02:00 and 05:00 ) than at the other time points in both dose groups , which corresponds to the main activity phase of the animals .
At 60 and 600 mg / kg / day , mean jejunal mucosa concentrations of COMPOUND_XXX were slightly to moderately higher at 20:00 , 23:00 and 08:00 than at the other time points , whereas PAG concentrations were generally in a similar range within each group at all time points with the exception of an increased value for the high - dose animals at 05:00 a.m. COMPOUND_XXX plasma concentrations were higher at night and in the early morning ( 23:00 , 02:00 and 05:00 ) than at the other time points in both dose groups , which corresponds to the main activity phase of the animals .
O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-GROUP I-GROUP O O O O O O O O O O O O