COMPOUND_XXX ( Batch no. 0351002 ) was administered orally by gavage as a suspension in 0.5 % ( w / v ) hydroxypropylmethylcellulose ( 0.5 % HPMC ) Type E4M Premium , aqueous solution , to four groups of beagle dogs ( N = 3 / sex / group ) at doses of 0 , 5 , 15 and 45 mg / kg / day base ( equivalent to 0 , 5.3 , 16.0 and 48.1 mg / kg COMPOUND_XXX salt , respectively based on the salt / base ratio of 1.069 ) .
COMPOUND_XXX ( Batch no. 0351002 ) was administered orally by gavage as a suspension in 0.5 % ( w / v ) hydroxypropylmethylcellulose ( 0.5 % HPMC ) Type E4M Premium , aqueous solution , to four groups of beagle dogs ( N = 3 / sex / group ) at doses of 0 , 5 , 15 and 45 mg / kg / day base ( equivalent to 0 , 5.3 , 16.0 and 48.1 mg / kg COMPOUND_XXX salt , respectively based on the salt / base ratio of 1.069 ) .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-GROUP I-GROUP I-GROUP I-GROUP I-GROUP O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O