Although there was no consistent difference in exposure observed between male and female dogs , the apparently greater AUC and Cmax values in females at 45 mg / kg / day , albeit with large variations , taken together with the clinical signs noted primarily in females at 45 mg / kg / day , and body weight and food consumption effects at the same dose , supports the conclusion that there was a greater exposure in females at the high dose .
Although there was no consistent difference in exposure observed between male and female dogs , the apparently greater AUC and Cmax values in females at 45 mg / kg / day , albeit with large variations , taken together with the clinical signs noted primarily in females at 45 mg / kg / day , and body weight and food consumption effects at the same dose , supports the conclusion that there was a greater exposure in females at the high dose .
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