In the worst case , the animals given the high dose were administered at the beginning of the study with a dose close to 273 mg / kg .
In the worst case , the animals given the high dose were administered at the beginning of the study with a dose close to 273 mg / kg .
O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE O