CONCLUSION The oral administration of COMPOUND_XXX the tosylate salt , up to the dose of 1000 mg base / kg over 26 weeks in male Wistar rats did not lead to any overt toxicity and , in particular , there was no change in serum glucose concentration .
CONCLUSION The oral administration of COMPOUND_XXX the tosylate salt , up to the dose of 1000 mg base / kg over 26 weeks in male Wistar rats did not lead to any overt toxicity and , in particular , there was no change in serum glucose concentration .
O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O O O O O O O