C0040 ) , was suspended in aqueous 0.5 % hydroxylpropyl methylcellulose ( Methocel ) solution and orally administered by gavage once daily to male Wistar rats over 3 days ( 8 animals per group ) or 4 weeks ( 10 animals plus 3 additional animals for toxicokinetics per group ) at 40 or 80 mg / kg using a dosage volume of 5 mL / kg .
C0040 ) , was suspended in aqueous 0.5 % hydroxylpropyl methylcellulose ( Methocel ) solution and orally administered by gavage once daily to male Wistar rats over 3 days ( 8 animals per group ) or 4 weeks ( 10 animals plus 3 additional animals for toxicokinetics per group ) at 40 or 80 mg / kg using a dosage volume of 5 mL / kg .
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