In conclusion , oral administration of the thyroid toxicant propylthiouracil ( PTU ) to male rats for 5 , 12 or 26 days produced time dependent changes in thyroid hormones ( increases in TSH , decreases in T3 and T4 ) and organ weight increases with correlative microscopic changes in the thyroid ( follicular cell hypertrophy ) and pituitary ( pars distalis hypertrophy ) which were consistent with a sustained disruption of the hypothalamic - pituitary - thyroid axis .
In conclusion , oral administration of the thyroid toxicant propylthiouracil ( PTU ) to male rats for 5 , 12 or 26 days produced time dependent changes in thyroid hormones ( increases in TSH , decreases in T3 and T4 ) and organ weight increases with correlative microscopic changes in the thyroid ( follicular cell hypertrophy ) and pituitary ( pars distalis hypertrophy ) which were consistent with a sustained disruption of the hypothalamic - pituitary - thyroid axis .
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