Two patches were applied at each dosing in groups 1 , 3 and 4 , and one patch was applied in group 2 .
Two patches were applied at each dosing in groups 1 , 3 and 4 , and one patch was applied in group 2 .
O O O O O O O O B-GROUP I-GROUP I-GROUP I-GROUP I-GROUP I-GROUP O O O O O O O B-GROUP I-GROUP O