Targets for toxicity : - Haemolymphopoietic system : decrease in platelet , erythrocyte and leukocyte counts and atrophic changes in the thymus - Changes observed in the spleen ( extramedullary haemopoiesis in the red splenic pulp ) and bone marrow ( increased number of megakaryocytes ) were considered as a rebound effect secondary to the decreased blood cell parameters and changes in the Mesenteric Lymph Nodes ( sinusal haemorrhage and large cells with large nucleus ) are also probably secondary to the decreased blood cell parameters .
Targets for toxicity : - Haemolymphopoietic system : decrease in platelet , erythrocyte and leukocyte counts and atrophic changes in the thymus - Changes observed in the spleen ( extramedullary haemopoiesis in the red splenic pulp ) and bone marrow ( increased number of megakaryocytes ) were considered as a rebound effect secondary to the decreased blood cell parameters and changes in the Mesenteric Lymph Nodes ( sinusal haemorrhage and large cells with large nucleus ) are also probably secondary to the decreased blood cell parameters .
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