At the end of the dosing period , at 1.0 mg / kg , the mean AUC ( 0 - 24h ) was 76.7 ± 18.5 ng.h / mL and 88.4 ± 37.8 ng.h / mL for males and females respectively , Cmax , was 23.2 ± 6.63 ng / mL and 22.9 ± 8.44 ng / mL for males and females respectively and tmax , was 0.5 ± 0 h and 0.6 ± 0.3 h for males and females respectively .
At the end of the dosing period , at 1.0 mg / kg , the mean AUC ( 0 - 24h ) was 76.7 ± 18.5 ng.h / mL and 88.4 ± 37.8 ng.h / mL for males and females respectively , Cmax , was 23.2 ± 6.63 ng / mL and 22.9 ± 8.44 ng / mL for males and females respectively and tmax , was 0.5 ± 0 h and 0.6 ± 0.3 h for males and females respectively .
O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O