At 100 mg / kg / day , samples from the kidney outer medulla were examined in electron miroscopy and compound - related ultrastructural changes were noted in the descending thin limb of the loop of Henle ( cell regeneration ) in the inner stripe of the outer medulla , the thick ascending limb of the loop of Henle ( cell degeneration / necrosis , increase in lysosomes number containing laminated membrane structures ) in the outer medulla ( both inner and outer stripes ) , in the outer medullary collecting ducts ( cell degeneration / necrosis ) , myelin figures ) and in the inner medullary collecting ducts ( myelin figures ) .
At 100 mg / kg / day , samples from the kidney outer medulla were examined in electron miroscopy and compound - related ultrastructural changes were noted in the descending thin limb of the loop of Henle ( cell regeneration ) in the inner stripe of the outer medulla , the thick ascending limb of the loop of Henle ( cell degeneration / necrosis , increase in lysosomes number containing laminated membrane structures ) in the outer medulla ( both inner and outer stripes ) , in the outer medullary collecting ducts ( cell degeneration / necrosis ) , myelin figures ) and in the inner medullary collecting ducts ( myelin figures ) .
O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O B-SPECIMEN I-SPECIMEN I-SPECIMEN O O O O O O O O O B-FINDING I-FINDING O O O O B-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN O B-FINDING I-FINDING O O O B-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN O O B-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN O B-FINDING I-FINDING I-FINDING I-FINDING O B-FINDING I-FINDING I-FINDING I-FINDING I-FINDING I-FINDING I-FINDING I-FINDING O O O B-SPECIMEN I-SPECIMEN O O B-FINDING I-FINDING I-FINDING I-FINDING O O O O B-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN O B-FINDING I-FINDING I-FINDING I-FINDING O O B-FINDING I-FINDING O O O O B-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN O B-FINDING I-FINDING O O