Compound - related microscopic findings were noted from 30 mg / kg / day in the diaphragm in males ( myofiber necrosis and regeneration ) and at 100 mg / kg / day in the adrenal gland in females ( increase in severity of the cell vacuolation in the zona glomerulosa ) , in the mesenteric lymph node in both sexes ( increase in enlarged pigmented macrophages aggregates number ) , in the kidney in both sexes ( tubular cell degeneration and regeneration , tubular cell anisokaryosis and karyomegaly , tubular dilatation and tubular cell mitoses ) affecting most tubules ( loop of Henle tubules and collecting ducts ) in the inner stripe of the outer medulla in males and females with a higher severity in males , and scattered tubules ( loop of Henle tubules , distal tubules and collecting ducts ) in the outer stripe of the outer medulla and in the cortex in males .
Compound - related microscopic findings were noted from 30 mg / kg / day in the diaphragm in males ( myofiber necrosis and regeneration ) and at 100 mg / kg / day in the adrenal gland in females ( increase in severity of the cell vacuolation in the zona glomerulosa ) , in the mesenteric lymph node in both sexes ( increase in enlarged pigmented macrophages aggregates number ) , in the kidney in both sexes ( tubular cell degeneration and regeneration , tubular cell anisokaryosis and karyomegaly , tubular dilatation and tubular cell mitoses ) affecting most tubules ( loop of Henle tubules and collecting ducts ) in the inner stripe of the outer medulla in males and females with a higher severity in males , and scattered tubules ( loop of Henle tubules , distal tubules and collecting ducts ) in the outer stripe of the outer medulla and in the cortex in males .
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