The toxicokinetic evaluation revealed , that systemic exposure and maximum serum concentrations of COMPOUND_XXX increased almost to the same extent as the dose increase from the mid to the high dose .
The toxicokinetic evaluation revealed , that systemic exposure and maximum serum concentrations of COMPOUND_XXX increased almost to the same extent as the dose increase from the mid to the high dose .
O O O O O O O O O O O O O O O O O O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION I-DOSE_QUALIFICATION I-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O