Histopathologic changes were present beginning at 160 mg / kg / day and included vacuolation in a wide variety of tissues , single - cell necrosis of the liver , and m inimal skeletal muscle degeneration / regeneration ; skeletal muscle necrosis was present at 400 mg / kg / day .
Histopathologic changes were present beginning at 160 mg / kg / day and included vacuolation in a wide variety of tissues , single - cell necrosis of the liver , and m inimal skeletal muscle degeneration / regeneration ; skeletal muscle necrosis was present at 400 mg / kg / day .
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