upwards : - decrease in packed cell volume ( p < 0.05 - p < 0.01 ) in males and females on day 25 , reversible at the mid dose on day 53 - decrease in mean cell volume ( p < 0.01 ) in males and females on day 25 , reversible at the mid dose on day 53 - increase in mean cell hemoglobin concentration ( p < 0.01 ) in males and females on day 25 , reversible at the mid dose on day 53 - increase in platelet count ( p < 0.01 ) in males and females at the mid dose on day 25 , reversible on day 53 Findings observed in animals exposed to COMPOUND_XXX at a daily dose of 160 pmol / kg bw .
upwards : - decrease in packed cell volume ( p < 0.05 - p < 0.01 ) in males and females on day 25 , reversible at the mid dose on day 53 - decrease in mean cell volume ( p < 0.01 ) in males and females on day 25 , reversible at the mid dose on day 53 - increase in mean cell hemoglobin concentration ( p < 0.01 ) in males and females on day 25 , reversible at the mid dose on day 53 - increase in platelet count ( p < 0.01 ) in males and females at the mid dose on day 25 , reversible on day 53 Findings observed in animals exposed to COMPOUND_XXX at a daily dose of 160 pmol / kg bw .
O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD O O O O O O O O O O B-SEX I-SEX I-SEX O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD O O O O O O B-SEX I-SEX I-SEX O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD O O O O O O B-SEX I-SEX I-SEX O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O O O O O O B-SEX I-SEX I-SEX O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O O O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O