Increased serum urea nitrogen and creatinine were observed in 4 animals with renal lesions at 25 mg / kg and higher after 14 and 26 weeks of dosing .
Increased serum urea nitrogen and creatinine were observed in 4 animals with renal lesions at 25 mg / kg and higher after 14 and 26 weeks of dosing .
B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O B-STUDY_TESTCD O O O O O O B-FINDING I-FINDING O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O