In conclusion , oral administration of COMPOUND_XXX by gavage to rats for 4 weeks resulted in test article - related statistically significant decreases in mean body weight and mean body weight gain in males at 60 mg / kg / day , organ weight changes in both sexes at 60 mg / kg / day and renal changes in males at doses ≥ 6 mg / kg / day .
In conclusion , oral administration of COMPOUND_XXX by gavage to rats for 4 weeks resulted in test article - related statistically significant decreases in mean body weight and mean body weight gain in males at 60 mg / kg / day , organ weight changes in both sexes at 60 mg / kg / day and renal changes in males at doses ≥ 6 mg / kg / day .
O O O O O O O O O O O O O O O O O O O O O O B-MANIFESTATION_FINDING O O B-STUDY_TESTCD I-STUDY_TESTCD O O B-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD O B-SEX O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O B-SPECIMEN B-STUDY_TESTCD B-MANIFESTATION_FINDING O B-SEX I-SEX O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O B-FINDING I-FINDING O B-SEX O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O