TT 2 : 2 Determination of organ weights , fixation and processing of tissues for histological examination - liver ( W ) * - mandibular lymph nodes - kidneys ( W ) - bone [ femur , sternum , both with - urinary bladder bone marrow ] - heart ( W ) - brain [ cerebrum , cerebellum , - atrium medulla oblongata ] ( W ) - lungs ( W ) * - spinal cord [ cervical segment ] - aorta thoracalis - peripheral nerve [ N. saphenus ] - vein [ vena cava caudalis ] - eye - trachea - harderian glands - esophagus - tongue - pituitary gland ( W ) [ B ] - salivary glands [ submandibular ] ( W ) - thyroid with parathyroid glands ( W ) - stomach - adrenal glands ( W ) - small intestine [ duodenum , - ovar ( W ) * jejunum , ileum ] - uterus [ horn , corpus , cervix ] ( W ) * - large intestine [ cecum , colon , rectum ] - vagina - pancreas ( W ) - mammary gland - skeletal muscle [ M. gastrocnemius ] - skin - and any other organ / tissue with - thymus ( W ) * macroscopic alterations , if necessary - spleen ( W ) for evaluating a diagnosis - iliac lymph nodes ( W ) ( w ) = Organ weight was recorded [ B ] = BOUIN 's fixative bold print = examined histologically in controls and top dose group * = additional histological examination in low and intermediate dose groups Bone marrow No compound - related effect was observed .
TT 2 : 2 Determination of organ weights , fixation and processing of tissues for histological examination - liver ( W ) * - mandibular lymph nodes - kidneys ( W ) - bone [ femur , sternum , both with - urinary bladder bone marrow ] - heart ( W ) - brain [ cerebrum , cerebellum , - atrium medulla oblongata ] ( W ) - lungs ( W ) * - spinal cord [ cervical segment ] - aorta thoracalis - peripheral nerve [ N. saphenus ] - vein [ vena cava caudalis ] - eye - trachea - harderian glands - esophagus - tongue - pituitary gland ( W ) [ B ] - salivary glands [ submandibular ] ( W ) - thyroid with parathyroid glands ( W ) - stomach - adrenal glands ( W ) - small intestine [ duodenum , - ovar ( W ) * jejunum , ileum ] - uterus [ horn , corpus , cervix ] ( W ) * - large intestine [ cecum , colon , rectum ] - vagina - pancreas ( W ) - mammary gland - skeletal muscle [ M. gastrocnemius ] - skin - and any other organ / tissue with - thymus ( W ) * macroscopic alterations , if necessary - spleen ( W ) for evaluating a diagnosis - iliac lymph nodes ( W ) ( w ) = Organ weight was recorded [ B ] = BOUIN 's fixative bold print = examined histologically in controls and top dose group * = additional histological examination in low and intermediate dose groups Bone marrow No compound - related effect was observed .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-GROUP I-GROUP I-GROUP I-GROUP I-GROUP O O O O O O B-GROUP I-GROUP I-GROUP I-GROUP I-GROUP O O O O O O O O O O