In all dose groups the systemic exposure decreased significantly to about 30 - 60 % after the last ( day 106 = week 16 ) compared to the first treatment ( day 1 ) with COMPOUND_XXX .
In all dose groups the systemic exposure decreased significantly to about 30 - 60 % after the last ( day 106 = week 16 ) compared to the first treatment ( day 1 ) with COMPOUND_XXX .
O O B-GROUP I-GROUP O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O