With COMPOUND_XXX , an increase in heart weight , but without morphological changes , was noted in oral rat studies with a duration of 4 weeks ( Studies XXXX and YYYY ) or 26 weeks ( Study MMMMM ) at systemic exposure values above 30000 ng ⋅ h / mL in terms of AUC ( 0 - 24h ) .
With COMPOUND_XXX , an increase in heart weight , but without morphological changes , was noted in oral rat studies with a duration of 4 weeks ( Studies XXXX and YYYY ) or 26 weeks ( Study MMMMM ) at systemic exposure values above 30000 ng ⋅ h / mL in terms of AUC ( 0 - 24h ) .
O O O O B-MANIFESTATION_FINDING O B-SPECIMEN B-STUDY_TESTCD O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O