In the course of the study the following compound - related or suspected compound - related findings were observed : At the mid dose group of 0.17 mg / kg COMPOUND_XXX and higher : - diarrhea in male animals - decrease in eosinophil count in males on day 6 after the first administration , decrease in albumin and albumin / globulin quotient in females on day 6 after the third administration and prolongation in activated partial thromboplastin time in males on day 6 after the sixth administration - single cell necrosis in the liver .
In the course of the study the following compound - related or suspected compound - related findings were observed : At the mid dose group of 0.17 mg / kg COMPOUND_XXX and higher : - diarrhea in male animals - decrease in eosinophil count in males on day 6 after the first administration , decrease in albumin and albumin / globulin quotient in females on day 6 after the third administration and prolongation in activated partial thromboplastin time in males on day 6 after the sixth administration - single cell necrosis in the liver .
O O O O O O O O O O O O O O O O O O O O O O B-GROUP I-GROUP I-GROUP O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O B-FINDING O B-SEX O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O B-SEX O O O O O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD O B-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD O B-SEX O O O O O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD O B-SEX O O O O O O O O B-FINDING I-FINDING I-FINDING O O B-SPECIMEN O