Test article - related microscopic changes in the spleen were decreased cellularity , lymphocytic , in all males and 9/10 females at 0.9 mglkg with decreased cellularity , red pulp in 2110 males and increased extramedullary hematopoiesis in all females at 0.9 mg / kg and 9/10 females at both 0.05 and 0.3 mglkg .
Test article - related microscopic changes in the spleen were decreased cellularity , lymphocytic , in all males and 9/10 females at 0.9 mglkg with decreased cellularity , red pulp in 2110 males and increased extramedullary hematopoiesis in all females at 0.9 mg / kg and 9/10 females at both 0.05 and 0.3 mglkg .
O O O O B-FINDING I-FINDING O O B-SPECIMEN O B-MANIFESTATION_FINDING B-STUDY_TESTCD O B-STUDY_TESTCD O O O B-SEX O O B-SEX O B-DOSE I-DOSE O B-MANIFESTATION_FINDING B-STUDY_TESTCD O B-FINDING I-FINDING O O B-SEX O B-FINDING I-FINDING I-FINDING O O B-SEX O B-DOSE I-DOSE I-DOSE I-DOSE O O B-SEX O O B-DOSE I-DOSE I-DOSE I-DOSE O