At 160 and 400 mg / kg / day , changes included vacuolation in a wide variety of tissues including macrophages and the glandular epithelium of many organs , degeneration / regeneration of cardiac muscle , and single - cell necrosis of the liver .
At 160 and 400 mg / kg / day , changes included vacuolation in a wide variety of tissues including macrophages and the glandular epithelium of many organs , degeneration / regeneration of cardiac muscle , and single - cell necrosis of the liver .
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