After administered dose was increased from 160 to 480 mg / kg / day ( 3-fold increase ) , in females , exposure increased with infra - dose proportionality on Day 1 and on Day 29 .
After administered dose was increased from 160 to 480 mg / kg / day ( 3-fold increase ) , in females , exposure increased with infra - dose proportionality on Day 1 and on Day 29 .
O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O O