The mean AUC ( 0 - 24h ) values on day 28 of treatment increased by factors of about 3.6 and 3.5 in female animals and about 5.2 and 1.8-fold in male animals , when the dose was increased from 4 to 20 mg / kg and from 20 to 100 mg / kg , respectively .
The mean AUC ( 0 - 24h ) values on day 28 of treatment increased by factors of about 3.6 and 3.5 in female animals and about 5.2 and 1.8-fold in male animals , when the dose was increased from 4 to 20 mg / kg and from 20 to 100 mg / kg , respectively .
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