Laboratory diagnostics All relevant compound - related or suspected compound - related effects observed in female animals can briefly be summarized as follows : Findings from the low dose of 5 mg / kg COMPOUND_XXX upwards : e increase in alkaline phosphatase on day 28 , which lasted until day 49 in animals of the high dose ( group 6 ) of 50 mg / kg COMPOUND_XXX In addition , findings from the mid dose of 15 mg / kg COMPOUND_XXX upwards : e increase in urinary volume associated with a decrease in specific gravity and an increase in PH value on day 22 , which was absent on day 51 Additional findings at the high dose of 50 mg / kg COMPOUND_XXX e increase in alanine aminotransferase on day 28 , which was absent on day 49 e decrease in calcium on day 28 , which lasted until day 49 e slight increase in gamma globulin on day 28 , which lasted until day 49 .
Laboratory diagnostics All relevant compound - related or suspected compound - related effects observed in female animals can briefly be summarized as follows : Findings from the low dose of 5 mg / kg COMPOUND_XXX upwards : e increase in alkaline phosphatase on day 28 , which lasted until day 49 in animals of the high dose ( group 6 ) of 50 mg / kg COMPOUND_XXX In addition , findings from the mid dose of 15 mg / kg COMPOUND_XXX upwards : e increase in urinary volume associated with a decrease in specific gravity and an increase in PH value on day 22 , which was absent on day 51 Additional findings at the high dose of 50 mg / kg COMPOUND_XXX e increase in alanine aminotransferase on day 28 , which was absent on day 49 e decrease in calcium on day 28 , which lasted until day 49 e slight increase in gamma globulin on day 28 , which lasted until day 49 .
O O O O O O O O O O O O O O O B-SEX O O O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-DOSE I-DOSE I-DOSE I-DOSE O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O O O O O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-GROUP I-GROUP O O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-DOSE I-DOSE I-DOSE I-DOSE O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O O O O O O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-DOSE I-DOSE I-DOSE I-DOSE O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O O O O O O O O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD O O O O O O O O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O O O O O O O O O O