In the low dose group with 12 sites of application and the high dose group with 6 sites , a steady state of concentrations was already reached after 13 weeks .
In the low dose group with 12 sites of application and the high dose group with 6 sites , a steady state of concentrations was already reached after 13 weeks .
O O B-GROUP I-GROUP I-GROUP O O O O O O O B-GROUP I-GROUP I-GROUP O O O O O O O O O O O O O O O O