Degenerative / necrotic hepatocellular changes were visualized only at 320 mg / kg and only for a few rats ( single hepatocellular necrosis for males , vacuolar degeneration / necrosis for females ) , whereas the regenerative changes ( hepatocellular anysokaryosis / karyomegalies and / or mitoses ) were already seen for some females at 160 mg / kg , and were seen for more males and females at 320 mg / kg .
Degenerative / necrotic hepatocellular changes were visualized only at 320 mg / kg and only for a few rats ( single hepatocellular necrosis for males , vacuolar degeneration / necrosis for females ) , whereas the regenerative changes ( hepatocellular anysokaryosis / karyomegalies and / or mitoses ) were already seen for some females at 160 mg / kg , and were seen for more males and females at 320 mg / kg .
B-FINDING I-FINDING I-FINDING I-FINDING I-FINDING O O O O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O B-FINDING I-FINDING O B-SEX O B-FINDING I-FINDING O B-FINDING O B-SEX O O O O O O O B-FINDING I-FINDING O B-FINDING O O O B-FINDING O O O O O O B-SEX O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O B-SEX I-SEX I-SEX O B-DOSE I-DOSE I-DOSE I-DOSE O