Summary of results and discussion Following suspected or clear - cut compound - related findings were observed : From 35 mg / kg COMPOUND_XXX onwards : - single or repeated vomitus over several days with dose - dependently increasing frequency and incidence in two animals of group 2 and all animals of groups 3 and 4 - _ slight decrease in systolic blood pressure in individual animals of all groups From 100 mg / kg COMPOUND_XXX onwards : - sialorrhea with dose - dependently increasing frequency and incidence in one animal of group 3 and all animals of group 4 - decrease in food intake in one animal of group 3 ( no. 8566 ) and in all animals of group 4 - decrease in water consumption in one animal of group 3 ( no. 8566 ) and in all animals of group 4 - distinct loss of body weight in one animal of group 3 ( no 8566 ) and in all animals of group 4 - decrease in heart rate in one animal of group 3 ( no. 8566 ) and in all animals of group 4 ; this effect provoked a prolongation of the PQ - and QT - intervals in the above - mentioned animals - _ slight increase in alkaline phosphatase on day 27 - slight increase in fibrinogen on day 27 - slight increase in sedimentation rate in one animal only of group 3 - emaciation of one animal each in group 3 and 4 - hypocellularity of bone marrow of femur and sternum .
Summary of results and discussion Following suspected or clear - cut compound - related findings were observed : From 35 mg / kg COMPOUND_XXX onwards : - single or repeated vomitus over several days with dose - dependently increasing frequency and incidence in two animals of group 2 and all animals of groups 3 and 4 - _ slight decrease in systolic blood pressure in individual animals of all groups From 100 mg / kg COMPOUND_XXX onwards : - sialorrhea with dose - dependently increasing frequency and incidence in one animal of group 3 and all animals of group 4 - decrease in food intake in one animal of group 3 ( no. 8566 ) and in all animals of group 4 - decrease in water consumption in one animal of group 3 ( no. 8566 ) and in all animals of group 4 - distinct loss of body weight in one animal of group 3 ( no 8566 ) and in all animals of group 4 - decrease in heart rate in one animal of group 3 ( no. 8566 ) and in all animals of group 4 ; this effect provoked a prolongation of the PQ - and QT - intervals in the above - mentioned animals - _ slight increase in alkaline phosphatase on day 27 - slight increase in fibrinogen on day 27 - slight increase in sedimentation rate in one animal only of group 3 - emaciation of one animal each in group 3 and 4 - hypocellularity of bone marrow of femur and sternum .
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