In addition , at the high dose of 20 mg / kg COMPOUND_XXX : - increased incidence of vomiting immediately after administration ; thinning of fur ; - decrease in fibrinogen and slight prolongation in thrombin time ; - acinar hypertrophy in the mandibular glands .
In addition , at the high dose of 20 mg / kg COMPOUND_XXX : - increased incidence of vomiting immediately after administration ; thinning of fur ; - decrease in fibrinogen and slight prolongation in thrombin time ; - acinar hypertrophy in the mandibular glands .
O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-DOSE I-DOSE I-DOSE I-DOSE O O O B-FINDING I-FINDING I-FINDING I-FINDING O O O O B-FINDING I-FINDING I-FINDING O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD O B-MANIFESTATION_FINDING I-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O O B-FINDING I-FINDING O O B-SPECIMEN I-SPECIMEN O