Test article - related microscopic observations were present in spleen ( decreased extramedullary hematopoiesis ) in females only at 30 mg / kg , thymus ( decreased cortical lymphocyte population ) in females only at 30 mg / kg , and thyroid ( decreased colloid and an increased cytoplasmic vacuolation of the follicular epithelial cells ) in females at 30 mg / kg and males at doses ≥ 10 mg / kg .
Test article - related microscopic observations were present in spleen ( decreased extramedullary hematopoiesis ) in females only at 30 mg / kg , thymus ( decreased cortical lymphocyte population ) in females only at 30 mg / kg , and thyroid ( decreased colloid and an increased cytoplasmic vacuolation of the follicular epithelial cells ) in females at 30 mg / kg and males at doses ≥ 10 mg / kg .
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