Genomic data indicated that the direct toxic component combined with the exacerbated pharmacological effect on c - kit expressing cells could represent a plausible explanation for the underlying mechanism of neoplastic changes observed in the 104 - week rat carcinogenicity study for urinary bladder , preputial gland , kidney cortex / medulla , and jejunum .
Genomic data indicated that the direct toxic component combined with the exacerbated pharmacological effect on c - kit expressing cells could represent a plausible explanation for the underlying mechanism of neoplastic changes observed in the 104 - week rat carcinogenicity study for urinary bladder , preputial gland , kidney cortex / medulla , and jejunum .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O