Key treatment - related findings included : • Slight , transient increase in food consumption at 150 and 400 mg / kg / day ; • Dose - proportional reductions in plasma glucose at all doses ; • Reversible decreases in serum glucose in males and females at 400 mg / kg / day ; • Reversible decreases in thymus and spleen weights at 400 mg / kg / day ; • Reversible increases in adrenal gland weight which correlated with cortical hypertrophy at 400 mg / kg / day ; • Sciatic nerve fiber degeneration at 150 and 400 mg / kg / day that showed resolution after four weeks of recovery .
Key treatment - related findings included : • Slight , transient increase in food consumption at 150 and 400 mg / kg / day ; • Dose - proportional reductions in plasma glucose at all doses ; • Reversible decreases in serum glucose in males and females at 400 mg / kg / day ; • Reversible decreases in thymus and spleen weights at 400 mg / kg / day ; • Reversible increases in adrenal gland weight which correlated with cortical hypertrophy at 400 mg / kg / day ; • Sciatic nerve fiber degeneration at 150 and 400 mg / kg / day that showed resolution after four weeks of recovery .
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