However , all of the high dose animals showed signs of menstruation during the study , so that the physiologic function of the organ did not seem significantly impaired .
However , all of the high dose animals showed signs of menstruation during the study , so that the physiologic function of the organ did not seem significantly impaired .
O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O O O O O O O O O O O O O O O O O O O O