The study is designed to establish a no - observed - adverse - effect level ( NOAEL ) , to establish a maximal tolerated dose , to estimate the toxicokinetic profile , and to estimate the potential for reversal of any toxic effects within a 4 - week post dosing period .
The study is designed to establish a no - observed - adverse - effect level ( NOAEL ) , to establish a maximal tolerated dose , to estimate the toxicokinetic profile , and to estimate the potential for reversal of any toxic effects within a 4 - week post dosing period .
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