Treatment at 10 mg / kg / day was increased to 100 mg / kg / day during week 22 but was subsequently reduced to 75 mg / kg / day from week 23 due to the presence of marked clinical signs in some individual animals .
Treatment at 10 mg / kg / day was increased to 100 mg / kg / day during week 22 but was subsequently reduced to 75 mg / kg / day from week 23 due to the presence of marked clinical signs in some individual animals .
O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O B-FINDING I-FINDING I-FINDING O O O O O