Dose levels of 60 and 180 mg / kg / day were selected based on data from a previous 2 year carcinogenicity study in rats , however , at 180 mg / kg / day , adverse clinical signs of subdued behavior , hunched posture , piloerection and red secretions around the eyes , the nose and the perineal were observed in some animals towards the end of the fourth week of dosing and in a couple of animals as early as the end of the second week of dosing .
Dose levels of 60 and 180 mg / kg / day were selected based on data from a previous 2 year carcinogenicity study in rats , however , at 180 mg / kg / day , adverse clinical signs of subdued behavior , hunched posture , piloerection and red secretions around the eyes , the nose and the perineal were observed in some animals towards the end of the fourth week of dosing and in a couple of animals as early as the end of the second week of dosing .
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