Laboratory diagnostics : - increase in aspartate aminotransferase ( AST ) was seen in week 1 ( only examined in male animals of the high dose group ) , in week 2 and in week 4 ( effect was reversible ) and an increase in alanine aminiotransferase ( ALT ) was observed in week 2 , in week 4 , and in week 8 ( effect was not reversible ) .
Laboratory diagnostics : - increase in aspartate aminotransferase ( AST ) was seen in week 1 ( only examined in male animals of the high dose group ) , in week 2 and in week 4 ( effect was reversible ) and an increase in alanine aminiotransferase ( ALT ) was observed in week 2 , in week 4 , and in week 8 ( effect was not reversible ) .
O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD O O O O O O O O O B-SEX O O O B-GROUP I-GROUP I-GROUP O O O O O O O O O O O O O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD O O O O O O O O O O O O O O O O O O O O O