Summary of results At the low dose of 5 mg / kg COMPOUND_XXX per day and higher : Clinical examinations : - vomiting occurred in male and female animals ( reversible after termination of treatment ) - a clear increase of the heart rate was noted in one male in week 3 ( 0.5 hours after administration ) and in two female animals in week 3 ( 0.5 hours after first administration ) and in week 4 ( prior to next administration ) .
Summary of results At the low dose of 5 mg / kg COMPOUND_XXX per day and higher : Clinical examinations : - vomiting occurred in male and female animals ( reversible after termination of treatment ) - a clear increase of the heart rate was noted in one male in week 3 ( 0.5 hours after administration ) and in two female animals in week 3 ( 0.5 hours after first administration ) and in week 4 ( prior to next administration ) .
O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O B-FINDING O O B-SEX I-SEX I-SEX O O O O O O O O O O O B-MANIFESTATION_FINDING O O B-STUDY_TESTCD I-STUDY_TESTCD O O O O B-SEX O O O O O O O O O O O O B-SEX O O O O O O O O O O O O O O O O O O O O O O