The persistent tissue / cell damage provoked by the combination of toxicity and exaggerated pharmacological effect of imatinib may have been leading to a chronic increase in cell proliferation Toxicokinetic investigations revealed that mean plasma concentrations of COMPOUND_XXX ( parent ) remained constant at all time points measured , however increased in an apparent dose proportional manner .
The persistent tissue / cell damage provoked by the combination of toxicity and exaggerated pharmacological effect of imatinib may have been leading to a chronic increase in cell proliferation Toxicokinetic investigations revealed that mean plasma concentrations of COMPOUND_XXX ( parent ) remained constant at all time points measured , however increased in an apparent dose proportional manner .
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