The study was designed to establish a no - observed adverse effect level ( NOAEL ) , to establish the maximum tolerated dose , to estimate the toxicokinetic profile , and to estimate the potential for reversal of any toxic effects within a 4 - week post dose period .
The study was designed to establish a no - observed adverse effect level ( NOAEL ) , to establish the maximum tolerated dose , to estimate the toxicokinetic profile , and to estimate the potential for reversal of any toxic effects within a 4 - week post dose period .
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