The following rounded values of Cmax and AUC ( o - 24h ) were observed on day 14 : COMPOUND_XXX Male Female COMPOUND_XXX - 666 Male Female 11 121 120 14 10 53 14 103 102 17 16 60 185 1810 1113 199 168 735 247 1637 1003 242 239 942 Cmax ( ng / ml ) 36 mg / day 108 mg / day 216 mg / day AUC o - 24h ( h.ng / ml ) 36 mg / day 108 mg / day 216 mg / day Because of the great between - animal variability , an increase of the concentration with the dose could not be demonstrated .
The following rounded values of Cmax and AUC ( o - 24h ) were observed on day 14 : COMPOUND_XXX Male Female COMPOUND_XXX - 666 Male Female 11 121 120 14 10 53 14 103 102 17 16 60 185 1810 1113 199 168 735 247 1637 1003 242 239 942 Cmax ( ng / ml ) 36 mg / day 108 mg / day 216 mg / day AUC o - 24h ( h.ng / ml ) 36 mg / day 108 mg / day 216 mg / day Because of the great between - animal variability , an increase of the concentration with the dose could not be demonstrated .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE B-DOSE I-DOSE I-DOSE I-DOSE B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE B-DOSE I-DOSE I-DOSE I-DOSE B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O