CONCLUSION In conclusion , the administration of COMPOUND_XXX by daily oral gavage for 3 or 10 days at dose levels of 0 , 50 mg / kg / day and 200 mg / kg / day resulted in clinical signs of dehydration and fur staining red , adverse reductions in body weight gain with associated reduced food consumption , minor hematology ( prolonged PT ) , biochemical ( increased BUN ) , significant urinalysis changes ( increased urinary protein and occult blood , glycosuria and polyuria ) , with associated macroscopic ( pale discolouration in medulla or corticomedullary junction ) and microscopic changes ( tubular degeneration / regeneration in the outer medulla ) in the kidney of rats treated with 200 mg / kg / day COMPOUND_XXX .
CONCLUSION In conclusion , the administration of COMPOUND_XXX by daily oral gavage for 3 or 10 days at dose levels of 0 , 50 mg / kg / day and 200 mg / kg / day resulted in clinical signs of dehydration and fur staining red , adverse reductions in body weight gain with associated reduced food consumption , minor hematology ( prolonged PT ) , biochemical ( increased BUN ) , significant urinalysis changes ( increased urinary protein and occult blood , glycosuria and polyuria ) , with associated macroscopic ( pale discolouration in medulla or corticomedullary junction ) and microscopic changes ( tubular degeneration / regeneration in the outer medulla ) in the kidney of rats treated with 200 mg / kg / day COMPOUND_XXX .
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