After 14 weeks of dosing , in the bone , dose dependent decreases in mature lamellar bone and trabecular bone were noted at 25 mg / kg and higher .
After 14 weeks of dosing , in the bone , dose dependent decreases in mature lamellar bone and trabecular bone were noted at 25 mg / kg and higher .
O O O O O O O O O O O O B-FINDING I-FINDING I-FINDING I-FINDING I-FINDING I-FINDING I-FINDING I-FINDING O O O B-DOSE I-DOSE I-DOSE I-DOSE O O O