At the terminal necropsy , organ weight changes included increased heart weights in males at doses : ; : : : 15 mg / kg / day and in females at 50 mg / kg / day ; decreased spleen weights in males at doses : ; : : : 15 mg!kg / day ; and at 50 mg / kg / day , increased adrenal weights in both sexes ; increased liver and thyroid weights in males ; increased ovary weights and decreased pituitary weights in females and decreased testis weights .
At the terminal necropsy , organ weight changes included increased heart weights in males at doses : ; : : : 15 mg / kg / day and in females at 50 mg / kg / day ; decreased spleen weights in males at doses : ; : : : 15 mg!kg / day ; and at 50 mg / kg / day , increased adrenal weights in both sexes ; increased liver and thyroid weights in males ; increased ovary weights and decreased pituitary weights in females and decreased testis weights .
O O O O O B-SPECIMEN B-STUDY_TESTCD B-MANIFESTATION_FINDING O B-MANIFESTATION_FINDING B-SPECIMEN B-STUDY_TESTCD O B-SEX O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O B-SEX O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O B-MANIFESTATION_FINDING B-SPECIMEN B-STUDY_TESTCD O B-SEX O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O B-MANIFESTATION_FINDING B-SPECIMEN B-STUDY_TESTCD O B-SEX I-SEX O B-MANIFESTATION_FINDING B-SPECIMEN O B-SPECIMEN B-STUDY_TESTCD O B-SEX O B-MANIFESTATION_FINDING B-SPECIMEN B-STUDY_TESTCD O B-MANIFESTATION_FINDING B-SPECIMEN B-STUDY_TESTCD O B-SEX O B-MANIFESTATION_FINDING B-SPECIMEN B-STUDY_TESTCD O