XXXXX ) was administered once weekly by intravenous injection as a solution in vehicle ( 20 % proypylene glycol / 80 % 0.1 M lactic acid and 4.3 % mannitol ) to 3 groups ( 3 sex / group ) of male and female beagle dogs ( Canis familiaris ) at doses of 0.2 , 0.6 and 1.2 mg / kg / week for 13 weeks .
XXXXX ) was administered once weekly by intravenous injection as a solution in vehicle ( 20 % proypylene glycol / 80 % 0.1 M lactic acid and 4.3 % mannitol ) to 3 groups ( 3 sex / group ) of male and female beagle dogs ( Canis familiaris ) at doses of 0.2 , 0.6 and 1.2 mg / kg / week for 13 weeks .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-GROUP I-GROUP I-GROUP I-GROUP O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O