At the end of the 26 - week dosing period , mean body weight was reduced in males by 4.7 , 11 and 15 % at doses of 10 , 30 and 75 mg / kg respectively , relative to concurrent controls ; mean body weight gain was reduced in males by 10 , 19 and 29 % at doses of 10 , 30 and 75 mg / kg and in females by 13 % at 75 mg / kg , relative to concurrent controls .
At the end of the 26 - week dosing period , mean body weight was reduced in males by 4.7 , 11 and 15 % at doses of 10 , 30 and 75 mg / kg respectively , relative to concurrent controls ; mean body weight gain was reduced in males by 10 , 19 and 29 % at doses of 10 , 30 and 75 mg / kg and in females by 13 % at 75 mg / kg , relative to concurrent controls .
O O O O O O O O O O O O B-STUDY_TESTCD I-STUDY_TESTCD O B-MANIFESTATION_FINDING O B-SEX O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O B-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD O B-MANIFESTATION_FINDING O B-SEX O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O B-SEX O O O O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O