These consisted of decreased thymus weights at doses ≥ 1 mg / kg ( males ) and 3 mg / kg ( females ) , lymphoid atrophy in both spleen and thymus at doses ≥ 1 mg / kg ( both sexes ) , and , in the spleen , increased pigment deposit at 3 mg / kg ( both sexes ) and increased extramedullary hematopoiesis at 3 mg / kg ( males ) .
These consisted of decreased thymus weights at doses ≥ 1 mg / kg ( males ) and 3 mg / kg ( females ) , lymphoid atrophy in both spleen and thymus at doses ≥ 1 mg / kg ( both sexes ) , and , in the spleen , increased pigment deposit at 3 mg / kg ( both sexes ) and increased extramedullary hematopoiesis at 3 mg / kg ( males ) .
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