AUC ( 0 - 24 ) values increased also less than dose - proportional from 30 to 100 mg / kg and did not increase relevantly from 100 to 300 mg / kg .
AUC ( 0 - 24 ) values increased also less than dose - proportional from 30 to 100 mg / kg and did not increase relevantly from 100 to 300 mg / kg .
O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O