Conclusion / Comments : one isolated case of subacute progressive hepatitis , probably of a spontaneous nature ( no hepatic finding at the highest tested dose ) , but not commonly encountered in rats of this strain and age , was observed in 1/3 females at 250 mg base / kg .
Conclusion / Comments : one isolated case of subacute progressive hepatitis , probably of a spontaneous nature ( no hepatic finding at the highest tested dose ) , but not commonly encountered in rats of this strain and age , was observed in 1/3 females at 250 mg base / kg .
O O O O O O O O B-FINDING I-FINDING I-FINDING O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-SEX O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O