The reference item ( as hydrochloride salt ) , batch No. 3 ( Labjournal ID : E-11502-058 ) , was dissolved in 80 mM sodium citrate buffer and administered to two groups each of 20 male rats at dosages of 5 and 15 mg base / kg / day and a dosage volume of 5 mL / kg , once daily , 7 days a week , for 2 or 4 weeks .
The reference item ( as hydrochloride salt ) , batch No. 3 ( Labjournal ID : E-11502-058 ) , was dissolved in 80 mM sodium citrate buffer and administered to two groups each of 20 male rats at dosages of 5 and 15 mg base / kg / day and a dosage volume of 5 mL / kg , once daily , 7 days a week , for 2 or 4 weeks .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O O O