The occurrence of a moderately increased M : E ratio for one high - dose female ( animal no. 4501 ) reflected a spectrum of histopathologic changes for this animal that were considered to be spontaneous and not related to COMPOUND_XXX treatment .
The occurrence of a moderately increased M : E ratio for one high - dose female ( animal no. 4501 ) reflected a spectrum of histopathologic changes for this animal that were considered to be spontaneous and not related to COMPOUND_XXX treatment .
O O O O B-FINDING I-FINDING I-FINDING I-FINDING I-FINDING I-FINDING O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION I-DOSE_QUALIFICATION B-SEX O O O O O O O O O B-FINDING I-FINDING O O O O O O O O O O O O O O O O