High - dose group 70 mg / kg / day : week 4 to the end of the treatment period - Leukopenia and mild myeloid hypoplasia of bone marrow - Minimally to slightly decreased platelet counts - Testes : decreased weight , severe tubular atrophy , moderate vacuolation of the seminiferous epithelium , slight interstitial cell hyperplasia , absence of spermatozoa in the epididymides - Moderate to marked cortical atrophy of the thymus in 2/6 dogs Mid-dose group ( 2 mg / kg / day ) - Body weight loss in 2/5 females - Mild myeloid hypoplasia of bone marrow - Testes : decreased weight , marked tubular atrophy , moderate vacuolation of the seminiferous epithelium , slight interstitial cell hyperplasia , absence of spermatozoa in the epididymides - Slight cortical atrophy of the thymus in 2/5 dogs Low - dose group ( 0.2 mg / kg / day ) In l / 3 males : - Testes : slight tubular atrophy , moderate vacuolation of the seminiferous epithelium , moderate germ cell degeneration , oligospermia in the epididymides .
High - dose group 70 mg / kg / day : week 4 to the end of the treatment period - Leukopenia and mild myeloid hypoplasia of bone marrow - Minimally to slightly decreased platelet counts - Testes : decreased weight , severe tubular atrophy , moderate vacuolation of the seminiferous epithelium , slight interstitial cell hyperplasia , absence of spermatozoa in the epididymides - Moderate to marked cortical atrophy of the thymus in 2/6 dogs Mid-dose group ( 2 mg / kg / day ) - Body weight loss in 2/5 females - Mild myeloid hypoplasia of bone marrow - Testes : decreased weight , marked tubular atrophy , moderate vacuolation of the seminiferous epithelium , slight interstitial cell hyperplasia , absence of spermatozoa in the epididymides - Slight cortical atrophy of the thymus in 2/5 dogs Low - dose group ( 0.2 mg / kg / day ) In l / 3 males : - Testes : slight tubular atrophy , moderate vacuolation of the seminiferous epithelium , moderate germ cell degeneration , oligospermia in the epididymides .
B-GROUP I-GROUP I-GROUP I-GROUP B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O B-FINDING O O B-FINDING I-FINDING O B-SPECIMEN I-SPECIMEN O O O O B-MANIFESTATION_FINDING B-STUDY_TESTCD I-STUDY_TESTCD O B-SPECIMEN O B-MANIFESTATION_FINDING B-STUDY_TESTCD O O B-FINDING I-FINDING O O B-FINDING O O B-SPECIMEN I-SPECIMEN O O B-FINDING I-FINDING I-FINDING O B-FINDING I-FINDING I-FINDING O O B-SPECIMEN O O O O B-FINDING I-FINDING O O B-SPECIMEN O O O B-GROUP I-GROUP O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O B-STUDY_TESTCD I-STUDY_TESTCD B-MANIFESTATION_FINDING O O B-SEX O O B-FINDING I-FINDING O B-SPECIMEN I-SPECIMEN O B-SPECIMEN O B-MANIFESTATION_FINDING B-STUDY_TESTCD O O B-FINDING I-FINDING O O B-FINDING O O B-SPECIMEN I-SPECIMEN O O B-FINDING I-FINDING I-FINDING O B-FINDING I-FINDING I-FINDING O O B-SPECIMEN O B-FINDING I-FINDING I-FINDING O O B-SPECIMEN O O O B-GROUP I-GROUP I-GROUP I-GROUP O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O B-SEX O O B-SPECIMEN O O B-FINDING I-FINDING O O B-FINDING O O B-SPECIMEN I-SPECIMEN O O B-FINDING I-FINDING I-FINDING O B-FINDING O O B-SPECIMEN O