Since no histological heart lesions related to treatment with COMPOUND_XXX were observed at 80 mg / kg after 4 weeks treatment or 60 mg / kg after 4 or 26 weeks treatment in previous toxicity studies in rats ( Studies 0510076 , 0370146 and 0580158 ) at similar systemic exposure to COMPOUND_XXX , the increase of these foci in some treated animals appears to be more likely an exacerbation of a background lesion due to treatment or an incidental finding not related to treatment rather than a direct effect of COMPOUND_XXX .
Since no histological heart lesions related to treatment with COMPOUND_XXX were observed at 80 mg / kg after 4 weeks treatment or 60 mg / kg after 4 or 26 weeks treatment in previous toxicity studies in rats ( Studies 0510076 , 0370146 and 0580158 ) at similar systemic exposure to COMPOUND_XXX , the increase of these foci in some treated animals appears to be more likely an exacerbation of a background lesion due to treatment or an incidental finding not related to treatment rather than a direct effect of COMPOUND_XXX .
O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-FINDING I-FINDING I-FINDING I-FINDING O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O