Additional alterations at 180 mg / kg included infiltration with macrophages in various tissues ( subcutaneous tissue , adipose tissue around preputial glands and prostate ) , subcutaneous edema , accumulation of histiocytes in subcutaneous lymph nodes , accumulation of alveolar macrophages in the lung ( frequently accompanied by purulent inflammation ) , bile duct and oval cell hyperplasia with peribiliary fibrosis and macrophage infiltration , vacuolation of bile duct epithelial and sinusoidal lining ( Kupffer ) cells and intravascular accumulation of macrophages in the liver .
Additional alterations at 180 mg / kg included infiltration with macrophages in various tissues ( subcutaneous tissue , adipose tissue around preputial glands and prostate ) , subcutaneous edema , accumulation of histiocytes in subcutaneous lymph nodes , accumulation of alveolar macrophages in the lung ( frequently accompanied by purulent inflammation ) , bile duct and oval cell hyperplasia with peribiliary fibrosis and macrophage infiltration , vacuolation of bile duct epithelial and sinusoidal lining ( Kupffer ) cells and intravascular accumulation of macrophages in the liver .
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