Compound - related microscopic changes were present at doses ≥ 10 mg / kg and included bone marrow atrophy ( females at doses ≥ 10 mg / kg , males at ≥ 30 mg / kg ) , increased pigment in the spleen ( both sexes at doses ≥ 10 mg / kg ) , thyroid follicular hypertrophy ( doses ≥ 10 mg / kg ) , thymic atrophy ( doses ≥ 30 mg / kg ) , increases in the frequency of oestrus phase of cycle ( 75 mg / kg ) , erythrophagocytosis of the mesenteric lymph node ( 75 mg / kg ) , lymphoid atrophy ( doses ≥ 30 mg / kg ) , atrophy of the male mammary gland ( doses ≥ 30 mg / kg ) .
Compound - related microscopic changes were present at doses ≥ 10 mg / kg and included bone marrow atrophy ( females at doses ≥ 10 mg / kg , males at ≥ 30 mg / kg ) , increased pigment in the spleen ( both sexes at doses ≥ 10 mg / kg ) , thyroid follicular hypertrophy ( doses ≥ 10 mg / kg ) , thymic atrophy ( doses ≥ 30 mg / kg ) , increases in the frequency of oestrus phase of cycle ( 75 mg / kg ) , erythrophagocytosis of the mesenteric lymph node ( 75 mg / kg ) , lymphoid atrophy ( doses ≥ 30 mg / kg ) , atrophy of the male mammary gland ( doses ≥ 30 mg / kg ) .
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