Conclusions As the findings observed after the low and mid dose are either of minor biological relevance ( sialorrhea and decrease in locomotive activity , vomitus , slight and reversible decreases in parameters of red blood cells ) or explainable by the pharmacological action ( reversible morphological alterations at reproductive organs ) of the compound which interferes with the endocrine system of the dog , the dose of 15 mg / kg COMPOUND_XXX is regarded as NOAEL in respect of the future use in female breast cancer patients .
Conclusions As the findings observed after the low and mid dose are either of minor biological relevance ( sialorrhea and decrease in locomotive activity , vomitus , slight and reversible decreases in parameters of red blood cells ) or explainable by the pharmacological action ( reversible morphological alterations at reproductive organs ) of the compound which interferes with the endocrine system of the dog , the dose of 15 mg / kg COMPOUND_XXX is regarded as NOAEL in respect of the future use in female breast cancer patients .
O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION I-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O O O O B-FINDING O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O B-FINDING O O O O B-MANIFESTATION_FINDING O O O B-STUDY_TESTCD I-STUDY_TESTCD I-STUDY_TESTCD O O O O O O O O O B-FINDING I-FINDING O B-SPECIMEN I-SPECIMEN O O O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O B-SEX O O O O