Sprague - Dawley derived rats ( 25 animals / sex / group ) were administered the hydrogen tartrate salt of COMPOUND_XXX at doses ofO , 0.2 , 0.6 , 1.8 or 3.0 mg / kg / day ( base equivalent dose levels 0 , 0.1 , 0.4 , 1.1 and 1.8 mg / kg / day , respectively ) by gavage in 1 % CMC for fifty - two weeks .
Sprague - Dawley derived rats ( 25 animals / sex / group ) were administered the hydrogen tartrate salt of COMPOUND_XXX at doses ofO , 0.2 , 0.6 , 1.8 or 3.0 mg / kg / day ( base equivalent dose levels 0 , 0.1 , 0.4 , 1.1 and 1.8 mg / kg / day , respectively ) by gavage in 1 % CMC for fifty - two weeks .
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