These changes were associated at the high dose with increased serum hepatic enzyme activities and serum hepatobiliary parameters , mainly in females , minimally ( mean values < 2 fold vs. controls ) for aspartate aminotransferase , glutamate deshydrogenase , alkaline phosphatase and total bilirubin , or slightly for alanine aminotransferase ( mean values up to 2.6-fold vs. controls ) .
These changes were associated at the high dose with increased serum hepatic enzyme activities and serum hepatobiliary parameters , mainly in females , minimally ( mean values < 2 fold vs. controls ) for aspartate aminotransferase , glutamate deshydrogenase , alkaline phosphatase and total bilirubin , or slightly for alanine aminotransferase ( mean values up to 2.6-fold vs. controls ) .
O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-MANIFESTATION_FINDING B-SPECIMEN B-STUDY_TESTCD I-STUDY_TESTCD O O B-SPECIMEN B-STUDY_TESTCD I-STUDY_TESTCD O O O B-SEX O B-MANIFESTATION_FINDING O O O O O O O O O O B-STUDY_TESTCD I-STUDY_TESTCD O B-STUDY_TESTCD I-STUDY_TESTCD O B-STUDY_TESTCD I-STUDY_TESTCD O B-STUDY_TESTCD I-STUDY_TESTCD O O O O B-STUDY_TESTCD I-STUDY_TESTCD O O O O O O O O O O