The exposure on Day 1 increased more than dose proportionally between 20 and 180 mg base / kg , suggesting a saturation of the hepatic first - pass , and an accumulation was observed between Day 1 and Day 7 ; whatever the dose , the exposure was higher in females than in males .
The exposure on Day 1 increased more than dose proportionally between 20 and 180 mg base / kg , suggesting a saturation of the hepatic first - pass , and an accumulation was observed between Day 1 and Day 7 ; whatever the dose , the exposure was higher in females than in males .
O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O