Summary of results The following compound - related or suspected compound - related findings were noted : At the low dose of 30 mg / kg COMPOUND_XXX and higher ( without dose - dependence if not otherwise mentioned ) : - increased sialorrhea , stained and encrusted mouth / snout - lower water consumption in males - slight decrease in total protein in males on day 24 - slight decrease in relative albumin in females on day 24 - slight decrease in albumin in females on days 24 and 54 ( not decreased at mid dose on day 54 ) - slight dose - dependent increase in total beta globulins in females on day 24 - slight decrease in albumin - globulin quotient in females on days 24 and 54 ( not decreased at mid dose on day 54 ) - dose - dependent decrease of N - demethylase activity in the liver in males - decrease of 7 - ethoxyresorufin deethylase activity in the liver in males in the liver of females In addition , at the mid dose of 100 mg / kg COMPOUND_XXX and higher ( without dose - dependence if not otherwise mentioned ) : - compulsive behavior ( increased frequency of cleaning behavior ) - slight decreases in reticulocyte count in males on day 25 - â € " slight decrease in total protein in females on day 24 - â € " slight dose - dependent decrease in absolute and relative weight of prostate and seminal vesicles ( without histopathological correlate ) - decrease of O - demethylase activity in the liver in males - decrease of aldrin epoxilase activity in the liver in males Additionally , at the high dose of 300 mg / kg COMPOUND_XXX : - slight decreases in red blood cell count and hemoglobin in males on day 25 - slight decrease in albumin in males on day 24 - slight increase in creatinine in males and females on day 24 - decrease of glutathione transferase activity in the liver of females Toxicokinetic evaluation revealed that exposure of female rats was about twice as much as of male rats with regard to Cmax and AUC ( 0 - 24 ) .
Summary of results The following compound - related or suspected compound - related findings were noted : At the low dose of 30 mg / kg COMPOUND_XXX and higher ( without dose - dependence if not otherwise mentioned ) : - increased sialorrhea , stained and encrusted mouth / snout - lower water consumption in males - slight decrease in total protein in males on day 24 - slight decrease in relative albumin in females on day 24 - slight decrease in albumin in females on days 24 and 54 ( not decreased at mid dose on day 54 ) - slight dose - dependent increase in total beta globulins in females on day 24 - slight decrease in albumin - globulin quotient in females on days 24 and 54 ( not decreased at mid dose on day 54 ) - dose - dependent decrease of N - demethylase activity in the liver in males - decrease of 7 - ethoxyresorufin deethylase activity in the liver in males in the liver of females In addition , at the mid dose of 100 mg / kg COMPOUND_XXX and higher ( without dose - dependence if not otherwise mentioned ) : - compulsive behavior ( increased frequency of cleaning behavior ) - slight decreases in reticulocyte count in males on day 25 - â € " slight decrease in total protein in females on day 24 - â € " slight dose - dependent decrease in absolute and relative weight of prostate and seminal vesicles ( without histopathological correlate ) - decrease of O - demethylase activity in the liver in males - decrease of aldrin epoxilase activity in the liver in males Additionally , at the high dose of 300 mg / kg COMPOUND_XXX : - slight decreases in red blood cell count and hemoglobin in males on day 25 - slight decrease in albumin in males on day 24 - slight increase in creatinine in males and females on day 24 - decrease of glutathione transferase activity in the liver of females Toxicokinetic evaluation revealed that exposure of female rats was about twice as much as of male rats with regard to Cmax and AUC ( 0 - 24 ) .
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