It is concluded that the oral administration of COMPOUND_XXX to dogs at dosages of 50 or 10 / 100/75 mg / kg / day for 34 weeks was associated with marked general toxicity and with microscopic alterations mainly in the liver , male and female reproductive organs and exocrine pancreas .
It is concluded that the oral administration of COMPOUND_XXX to dogs at dosages of 50 or 10 / 100/75 mg / kg / day for 34 weeks was associated with marked general toxicity and with microscopic alterations mainly in the liver , male and female reproductive organs and exocrine pancreas .
O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O B-FINDING I-FINDING O O B-FINDING I-FINDING O O O B-SPECIMEN O B-SEX I-SEX I-SEX B-SPECIMEN I-SPECIMEN O B-SPECIMEN I-SPECIMEN O