Clinical examination : General observations : The following findings were considered to be compound - related : At the low dose of 1.0 mg / kg COMPOUND_XXX and higher : e Signs of local irritation at the area of administration such as reddening and / or swelling of the skin at the snout were observed in male and female animals with dose - dependent increase in severity and in onset of the finding .
Clinical examination : General observations : The following findings were considered to be compound - related : At the low dose of 1.0 mg / kg COMPOUND_XXX and higher : e Signs of local irritation at the area of administration such as reddening and / or swelling of the skin at the snout were observed in male and female animals with dose - dependent increase in severity and in onset of the finding .
O O O O O O O O O O O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O B-FINDING O O O O O O O B-FINDING O O O B-FINDING O O B-SPECIMEN I-SPECIMEN I-SPECIMEN I-SPECIMEN O O O B-SEX I-SEX I-SEX O O O O O O O O O O O O O O O