Key treatment - related findings included : Moribund sacrifice of one 450 mg / kg / day female on day 2 due to severe hypoglycemia ; In - life observations of splayed posture , hypoactivity , piloerection , and increased respiration rate in surviving females in the 450 mg / kg / day dose group ; Slightly increased food consumption in the 450 mg / kg / day dose group ; Dose - proportional reductions in plasma glucose at all doses ; An increase in adrenal weights at 450 mg / kg / day ; An approximate 30 - 50 % decrease in serum glucose in males and females at 450 mg / kg / day and in females at 150 mg / kg / day ; Sciatic nerve fiber degeneration at 150 and 450 mg / kg / day .
Key treatment - related findings included : Moribund sacrifice of one 450 mg / kg / day female on day 2 due to severe hypoglycemia ; In - life observations of splayed posture , hypoactivity , piloerection , and increased respiration rate in surviving females in the 450 mg / kg / day dose group ; Slightly increased food consumption in the 450 mg / kg / day dose group ; Dose - proportional reductions in plasma glucose at all doses ; An increase in adrenal weights at 450 mg / kg / day ; An approximate 30 - 50 % decrease in serum glucose in males and females at 450 mg / kg / day and in females at 150 mg / kg / day ; Sciatic nerve fiber degeneration at 150 and 450 mg / kg / day .
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