Furthermore , as the single cell necrosis in the liver , reported in individual animals , was not related to significant organ dysfunction , the high dose of 0.5 mg / kg COMPOUND_XXX ( ca. 6.0 mg / m 2 BSA ) is considered as MTD .
Furthermore , as the single cell necrosis in the liver , reported in individual animals , was not related to significant organ dysfunction , the high dose of 0.5 mg / kg COMPOUND_XXX ( ca. 6.0 mg / m 2 BSA ) is considered as MTD .
O O O O B-FINDING I-FINDING I-FINDING O O B-SPECIMEN O O O O O O O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O