Treatment with the positive control agent propylthiouracil , a model thyroid toxicant , resulted in time - dependent , moderate to severe and statistically significant changes in thyroid hormone levels ( increases in TSH , decreases in T3 , T4 and free T4 ) , organ weight increases in pituitary and thyroid which correlated with the macroscopic change of enlarged thyroid and microscopic changes in the thyroid ( follicular cell hypertrophy ) and pituitary ( pars distalis hypertrophy ) .
Treatment with the positive control agent propylthiouracil , a model thyroid toxicant , resulted in time - dependent , moderate to severe and statistically significant changes in thyroid hormone levels ( increases in TSH , decreases in T3 , T4 and free T4 ) , organ weight increases in pituitary and thyroid which correlated with the macroscopic change of enlarged thyroid and microscopic changes in the thyroid ( follicular cell hypertrophy ) and pituitary ( pars distalis hypertrophy ) .
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