Conclusion Repeated daily oral administration of COMPOUND_XXX at doses from 30 to 300 mg / kg in rats was tolerated with only few clinical findings indicating the first signs of discomfort , minor changes in hematological and biochemical parameters at the low dose of 30 mg / kg and higher as well as reduced organ weights of the prostate and seminal vesicle at the mid dose of 100 mg / kg and higher .
Conclusion Repeated daily oral administration of COMPOUND_XXX at doses from 30 to 300 mg / kg in rats was tolerated with only few clinical findings indicating the first signs of discomfort , minor changes in hematological and biochemical parameters at the low dose of 30 mg / kg and higher as well as reduced organ weights of the prostate and seminal vesicle at the mid dose of 100 mg / kg and higher .
O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O B-FINDING I-FINDING O O O B-FINDING I-FINDING I-FINDING O O B-FINDING I-FINDING I-FINDING I-FINDING I-FINDING I-FINDING O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-DOSE I-DOSE I-DOSE I-DOSE O O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD O O B-SPECIMEN O B-SPECIMEN I-SPECIMEN O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-DOSE I-DOSE I-DOSE I-DOSE O O O