XXXXX ) was administered once weekly by intravenous injection as a solution in vehicle ( 20 % propylene glycol / 80 % 0.1 M lactic acid and 4.3 % mannitol ) to 3 groups ( 10 - 12 / sex / group ) of male and female Han Wistar rats at doses of 0.3 , 1.0 and 3.0 mg / kg for at least 13 weeks .
XXXXX ) was administered once weekly by intravenous injection as a solution in vehicle ( 20 % propylene glycol / 80 % 0.1 M lactic acid and 4.3 % mannitol ) to 3 groups ( 10 - 12 / sex / group ) of male and female Han Wistar rats at doses of 0.3 , 1.0 and 3.0 mg / kg for at least 13 weeks .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-GROUP I-GROUP I-GROUP I-GROUP I-GROUP I-GROUP I-GROUP O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O