The purpose of this exploratory oral toxicity study in rats was to investigate potential modes of action by which COMPOUND_XXX , a tyrosine kinase inhibitor , may induce proliferative changes that potentially lead to the hyperplasia / neoplasia in the urogenital tract observed in a two - year carcinogenicity study in rats ( Study No. 0210027 ) .
The purpose of this exploratory oral toxicity study in rats was to investigate potential modes of action by which COMPOUND_XXX , a tyrosine kinase inhibitor , may induce proliferative changes that potentially lead to the hyperplasia / neoplasia in the urogenital tract observed in a two - year carcinogenicity study in rats ( Study No. 0210027 ) .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-FINDING O B-FINDING O O B-SPECIMEN I-SPECIMEN O O O O O O O O O O O O O O O O