COMPOUND_XXX was administered by oral intubation to four groups of male and female rats ( 6 / sex / group ) at dose levels of 0 ( vehicle control ) , 225 and 500 mg / kg / day of material produced from a new route of chemical synthesis ( NS ) and 500 mg / kg / day of material produced from the old route of chemical synthesis ( OS ) for four weeks .
COMPOUND_XXX was administered by oral intubation to four groups of male and female rats ( 6 / sex / group ) at dose levels of 0 ( vehicle control ) , 225 and 500 mg / kg / day of material produced from a new route of chemical synthesis ( NS ) and 500 mg / kg / day of material produced from the old route of chemical synthesis ( OS ) for four weeks .
O O O O O O O O O O O O O O O B-GROUP I-GROUP I-GROUP I-GROUP I-GROUP O O O O O B-GROUP I-GROUP I-GROUP I-GROUP I-GROUP O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O