In conclusion , administration of COMPOUND_XXX by oral gavage to beagle dogs caused reddened ears , increased alanine aminotransferase , alkaline phosphatase and total bilirubin , and microscopic changes in the liver at 60 mg / kg / day .
In conclusion , administration of COMPOUND_XXX by oral gavage to beagle dogs caused reddened ears , increased alanine aminotransferase , alkaline phosphatase and total bilirubin , and microscopic changes in the liver at 60 mg / kg / day .
O O O O O O O O O O O O O B-FINDING B-SPECIMEN O B-MANIFESTATION_FINDING B-STUDY_TESTCD I-STUDY_TESTCD O B-STUDY_TESTCD I-STUDY_TESTCD O B-STUDY_TESTCD I-STUDY_TESTCD O O B-FINDING I-FINDING O O B-SPECIMEN O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O