Five groups of 6 male and 6 female rats for the toxicity study and five groups of 10 male and 10 female rats for the toxicokinetic study were given 0 , 30 , 100 , 300 or 600 mg / kg / day for five days .
Five groups of 6 male and 6 female rats for the toxicity study and five groups of 10 male and 10 female rats for the toxicokinetic study were given 0 , 30 , 100 , 300 or 600 mg / kg / day for five days .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O