This incident was considered not to prevent from meeting the study objectives , because first , clear toxic effects were noted at this high dose level already starting from the mid dose level , and second , increased systemic exposure of the animals to the unchanged test substance was shown at the high dose level .
This incident was considered not to prevent from meeting the study objectives , because first , clear toxic effects were noted at this high dose level already starting from the mid dose level , and second , increased systemic exposure of the animals to the unchanged test substance was shown at the high dose level .
O O O O O O O O O O O O O O O O B-FINDING I-FINDING I-FINDING O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O O O O O O O O O O O O O O O O O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O O