In addition , at the high dose group of 0.5 mg / kg COMPOUND_XXX : - diarrhea in female animals - decrease in food consumption in female animals usually occurring 5 - 8 days after administration - increase in total alpha globulin in females mainly on day 6 after administration , decreases in reticulocytes in males and females mainly on day 6 after administration , decreases in MCHC in females from day 3 to day 17 after the sixth administration , decreases in WBC , lymphocyte count , eosinophil count in males and females between days 3 and 10 after administration , decrease in basophil count in males on days 3 and 6 after the sixth administration , slight increase in platelet count in females between days 6 and 13 after administration - in the bone marrow approximately 3 weeks after the sixth administration : decrease in mature erythrocytes in males and increase in the ratio of immature to mature granulocytes in females as well as decrease in the ratio of erythopoiesis to granulopoiesis in males - liver findings : yellowish discoloration and focal gray - white discoloration / s ; periportal hepatocellular hypertrophy ; periportal vacuolation , in one male associated with an acute focal necrosis ; focal fatty changes .
In addition , at the high dose group of 0.5 mg / kg COMPOUND_XXX : - diarrhea in female animals - decrease in food consumption in female animals usually occurring 5 - 8 days after administration - increase in total alpha globulin in females mainly on day 6 after administration , decreases in reticulocytes in males and females mainly on day 6 after administration , decreases in MCHC in females from day 3 to day 17 after the sixth administration , decreases in WBC , lymphocyte count , eosinophil count in males and females between days 3 and 10 after administration , decrease in basophil count in males on days 3 and 6 after the sixth administration , slight increase in platelet count in females between days 6 and 13 after administration - in the bone marrow approximately 3 weeks after the sixth administration : decrease in mature erythrocytes in males and increase in the ratio of immature to mature granulocytes in females as well as decrease in the ratio of erythopoiesis to granulopoiesis in males - liver findings : yellowish discoloration and focal gray - white discoloration / s ; periportal hepatocellular hypertrophy ; periportal vacuolation , in one male associated with an acute focal necrosis ; focal fatty changes .
O O O O O B-GROUP I-GROUP I-GROUP O B-DOSE I-DOSE I-DOSE I-DOSE O O O B-FINDING O B-SEX O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O B-SEX O O O O O O O O O O B-MANIFESTATION_FINDING O O B-STUDY_TESTCD I-STUDY_TESTCD O B-SEX O O O O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD O B-SEX I-SEX I-SEX O O O O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD O B-SEX O O O O O O O O O O O B-MANIFESTATION_FINDING O O O B-STUDY_TESTCD I-STUDY_TESTCD O B-STUDY_TESTCD I-STUDY_TESTCD O B-SEX I-SEX I-SEX O O O O O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O B-SEX O O O O O O O O O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O B-SEX O O O O O O O O O O B-SPECIMEN I-SPECIMEN O O O O O O O O B-MANIFESTATION_FINDING O O B-STUDY_TESTCD O B-SEX O B-MANIFESTATION_FINDING O O O O O O O B-STUDY_TESTCD O B-SEX O O O B-MANIFESTATION_FINDING O O O O O O B-FINDING O B-SEX O B-SPECIMEN B-FINDING O B-FINDING I-FINDING O B-FINDING I-FINDING I-FINDING I-FINDING I-FINDING O O O B-FINDING I-FINDING I-FINDING O B-FINDING I-FINDING O O O B-SEX O O O O B-FINDING I-FINDING O O B-FINDING I-FINDING O