Ophthalmoscopic examinations not reveal any ocular changes attributable to treatment with COMPOUND_XXX and there were no electrocardiographic abnormalities associated with the intravenous administration ofCOMPOUND_XXX Test article - related organ weight decreases were noted in the thyroid in both sexes ( ~ 0.06 mg / kg / day in females , 0.6 mg / kg / day in males ) and in the liver of males only ( ~ 0.2 mg / kg / day ) .
Ophthalmoscopic examinations not reveal any ocular changes attributable to treatment with COMPOUND_XXX and there were no electrocardiographic abnormalities associated with the intravenous administration ofCOMPOUND_XXX Test article - related organ weight decreases were noted in the thyroid in both sexes ( ~ 0.06 mg / kg / day in females , 0.6 mg / kg / day in males ) and in the liver of males only ( ~ 0.2 mg / kg / day ) .
O O O O O O O O O O O O O O O O O O O O O O O O O O O O O B-STUDY_TESTCD B-MANIFESTATION_FINDING O O O O B-SPECIMEN O B-SEX I-SEX O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O B-SEX O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O B-SEX O O O O B-SPECIMEN O B-SEX O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O