The higher exposure in females resulted in compound - related effects seen either exclusively or at lower doses in females , including partly to completely reversible clinical chemistry changes in males at 110 mg / kg / day and females at ≥ 30 mg / kg / day ; irreversible increases in adrenal gland and kidney weight and partially reversible liver weight increases in females at 110 mg / kg / day ; reversible macroscopic light pale colored kidneys in females at ≥ 30 mg / kg / day ; and partially to completely reversible microscopic kidney findings in males at 110 mg / kg / day and females at ≥ 10 mg / kg / day , as well as reversible and nonadverse microscopic liver findings in females at 110 mg / kg / day .
The higher exposure in females resulted in compound - related effects seen either exclusively or at lower doses in females , including partly to completely reversible clinical chemistry changes in males at 110 mg / kg / day and females at ≥ 30 mg / kg / day ; irreversible increases in adrenal gland and kidney weight and partially reversible liver weight increases in females at 110 mg / kg / day ; reversible macroscopic light pale colored kidneys in females at ≥ 30 mg / kg / day ; and partially to completely reversible microscopic kidney findings in males at 110 mg / kg / day and females at ≥ 10 mg / kg / day , as well as reversible and nonadverse microscopic liver findings in females at 110 mg / kg / day .
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