Compound - related changes in thyroid hormones measured at the end of the dosing period consisted of slight reductions in thyroid stimulating hormone ( decreased by 13.2 and 14.6 % for females at 1.0 and 3.0 mg / kg respectively ) , slight increases in tetraiodothyronine ( T4 ) ( increased by 21.9 and 18.3 % for females at 1.0 and 3.0 mg / kg respectively ) , and slight increases in T3 levels ( increased by 26 and 19 % respectively for males at 1.0 and 3.0 mg / kg , respectively ) , relative to concurrent controls .
Compound - related changes in thyroid hormones measured at the end of the dosing period consisted of slight reductions in thyroid stimulating hormone ( decreased by 13.2 and 14.6 % for females at 1.0 and 3.0 mg / kg respectively ) , slight increases in tetraiodothyronine ( T4 ) ( increased by 21.9 and 18.3 % for females at 1.0 and 3.0 mg / kg respectively ) , and slight increases in T3 levels ( increased by 26 and 19 % respectively for males at 1.0 and 3.0 mg / kg , respectively ) , relative to concurrent controls .
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