Slight to moderate increase in heart rate two hours after dosing , not dose - related in males from 0.05 mg / kg / day upwards or in females from 0.01 mg / kg / day .
Slight to moderate increase in heart rate two hours after dosing , not dose - related in males from 0.05 mg / kg / day upwards or in females from 0.01 mg / kg / day .
O O O B-MANIFESTATION_FINDING O B-STUDY_TESTCD I-STUDY_TESTCD O O O O O O O O O O B-SEX O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O B-SEX O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O