From macroscopic and microscopic observations at premature and / or terminal kill , degenerative / atrophic changes were seen in the haemolymphopoietic system , lungs , intestines and ovaries mainly at the dose level of 40 mg / kg and were considered as toxicological targets of the compound COMPOUND_XXX as follows : - the bone marrow hypocellularity was noted in all animals given 40 mg / kg and was the histological correlate of the fluid femoral bone marrow seen for 5/10 males and 4/7 prematurely killed females given 40 mg / kg .
From macroscopic and microscopic observations at premature and / or terminal kill , degenerative / atrophic changes were seen in the haemolymphopoietic system , lungs , intestines and ovaries mainly at the dose level of 40 mg / kg and were considered as toxicological targets of the compound COMPOUND_XXX as follows : - the bone marrow hypocellularity was noted in all animals given 40 mg / kg and was the histological correlate of the fluid femoral bone marrow seen for 5/10 males and 4/7 prematurely killed females given 40 mg / kg .
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