A treatment - related decrease in absolute and relative mean weights of the thymus was observed in mice treated at 100 , 200 or 300 mg / kg / day , with evidence of dose - response relationship ( up to about 50 % to 60 % lower than the control absolute values at 200 and 300 mg / kg ) .
A treatment - related decrease in absolute and relative mean weights of the thymus was observed in mice treated at 100 , 200 or 300 mg / kg / day , with evidence of dose - response relationship ( up to about 50 % to 60 % lower than the control absolute values at 200 and 300 mg / kg ) .
O O O O B-MANIFESTATION_FINDING O O O O O B-STUDY_TESTCD O O B-SPECIMEN O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O O