CONCLUSION In conclusion , the oral administration of COMPOUND_XXX as nanocrystal dispersion ( NCD ) for 1 month to dogs at doses of 0.05 , 0.15 or 1.0 ( 1.5 ) mg / kg / day lead to early sacrifices for humane reasons in two dogs of the high dose group showing rectum prolaps or intussusception of jejunum and ileum .
CONCLUSION In conclusion , the oral administration of COMPOUND_XXX as nanocrystal dispersion ( NCD ) for 1 month to dogs at doses of 0.05 , 0.15 or 1.0 ( 1.5 ) mg / kg / day lead to early sacrifices for humane reasons in two dogs of the high dose group showing rectum prolaps or intussusception of jejunum and ileum .
O O O O O O O O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O B-FINDING O O O O O O O O B-GROUP I-GROUP I-GROUP O B-SPECIMEN B-FINDING O B-FINDING O B-SPECIMEN O B-SPECIMEN O