Conclusion / Comments : Strong evidence of phospholipidosis ( based on histomorphological changes noted in lungs , spleen and liver ) at 170 mg base / kg and hepatic enzyme changes ( induction and / or inhibition ) from 60 mg base / kg .
Conclusion / Comments : Strong evidence of phospholipidosis ( based on histomorphological changes noted in lungs , spleen and liver ) at 170 mg base / kg and hepatic enzyme changes ( induction and / or inhibition ) from 60 mg base / kg .
O O O O O O O B-FINDING O O O B-FINDING I-FINDING O O B-SPECIMEN I-SPECIMEN B-SPECIMEN O B-SPECIMEN O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O B-STUDY_TESTCD I-STUDY_TESTCD B-MANIFESTATION_FINDING I-MANIFESTATION_FINDING I-MANIFESTATION_FINDING I-MANIFESTATION_FINDING I-MANIFESTATION_FINDING I-MANIFESTATION_FINDING I-MANIFESTATION_FINDING I-MANIFESTATION_FINDING O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O