Hepatic effects were predominant throughout all groups and progressed from histologic evidence at the lowest dose ( 30 mg / kg / day ) to clinical pathology findings and gross necropsy findings at the mid-dose ( 200 mg / kg / day ) and the high dose ( 600 mg / kg / day ) .
Hepatic effects were predominant throughout all groups and progressed from histologic evidence at the lowest dose ( 30 mg / kg / day ) to clinical pathology findings and gross necropsy findings at the mid-dose ( 200 mg / kg / day ) and the high dose ( 600 mg / kg / day ) .
B-FINDING I-FINDING O O O B-GROUP I-GROUP O O O B-FINDING I-FINDING O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O B-FINDING I-FINDING I-FINDING O B-FINDING I-FINDING I-FINDING O O B-DOSE_QUALIFICATION O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O O B-DOSE_QUALIFICATION I-DOSE_QUALIFICATION O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O