Test - article related histopathology findings were also observed in the daily - dosed 200 and 270 mg / kg rats ( Groups 3 and 4 ) , characterized by acanthosis , parakeratosis , ulceration , and pustule formation , and were minimal to moderate in nature .
Test - article related histopathology findings were also observed in the daily - dosed 200 and 270 mg / kg rats ( Groups 3 and 4 ) , characterized by acanthosis , parakeratosis , ulceration , and pustule formation , and were minimal to moderate in nature .
O O O O O O O O O O O O O O B-DOSE I-DOSE I-DOSE I-DOSE I-DOSE I-DOSE O O B-GROUP I-GROUP I-GROUP I-GROUP O O O O B-FINDING O B-FINDING O B-FINDING O O B-FINDING O O O O O O O O O O