"My mom was switched to Rytary to decrease off periods.  She used to be able to walk one mile.   At first the Rytary seemed great, but then her neurologist couldn't get a dose that worked consistently.  The manufacturer says absorption is 70%, her Neuro says 50%, but sometimes it was 0% and when we would add some immediate release levodopa, she would get horrible dyskinesia.  She could barely walk and we've switched back to old meds with little improvement.  I regret ever switching!!"