"I'm 5'4" 45 years old, started at 225, took other meds got to 212, doc put me on these to help with cravings, and just being hungry all the time , started Dec 18th, I probably gained some over Christmas, this morning I'm 208, no major issues, definitely has helped being hungry, and cravings, on 2:1, Friday I'll move to full dose. I am more regular so no constipation, or diarrhea. I did wake up a few nights with heart palpitations, but I think it was from eating dark chocolate. Only reason I'm not giving it a 10 is I'm not on full dose, or long enough to know if it will stay this effective for me."