"So we are still learning about methylfolate and its effects in depression as it's still pretty new (megavitamin) and we're still learning about the role genetics play in the methylation cycle. I noticed a boost after a week on 15mg then it disappeared. I kept taking even though it wasn't really working anymore. Then after about six weeks I got a huge boost and as I was also on Wellbutrin at the time, it was actually way too much serotonin in my system. I think some people need doses much lower than the prescription strength and it can take a while for the full effect to kick in. It can take a little while to get back to a healthy level but it can definitely help boost whatever else you're on. Look out for hypomania if you're bipolar."