"Make sure and take the shot on your thigh. It hurts less. Also, do not buy into the advice about icing the area or letting the shot sit out for a bit to warm up some. It hurts the same. I have been on Enbrel for five months. The big red spots do go down after a week on the first few shots and after a month you only get a mark for a day or two. My advice is to give yourself your shot on a Sunday and by the weekend you'll have no mark. I am in college and it is not that bad. I am on 50 mg which has not worked well and my doctor is going to increase my dosage. It helps some, but Celebrex is still my go-to for pain. Wash your hands a lot!"