"I'm very treatment resistant bipolar type 2, typically severely depressed, with OCD and several other comorbid diagnoses, and antidepressants for me, IF they work, will tend to poop out after only a few weeks to a few months. This was not the case for duloxetine. I started on 60 mg and it worked wonderfully for several months, the longest any antidepressant has worked for me. Then, that summer, I became depressed again. After trials of other meds, I wound up back on duloxetine, this time at 90 mg, which worked for another 6 months. I begged for 120 mg but for some reason my psychiatrist refused to prescribe it, so I had to switch to something else. Recently I wound up back on it for about a month or so at 120 mg, then at 80 mg."