DerPathologe.60170181.ger.abstr-passage-0
abstract
Mutationen des p53-Tumorsuppressorgens lassen sich in etwa 50 % aller menschlichen Tumoren nachweisen . Seine Bedeutung fuer die Entstehung menschlicher Krebserkrankungen macht dieses Gen zu einem zentralen Interesse molekularpathologischer Untersuchungen , die die Erfassung pathogenetischer diagnostischer und prognostischer Parameter , in der Tumorpathologie zum Inhalt haben . In dieser Uebersichtsarbeit werden wesentliche Aspekte der Funktion des p53-Tumorsuppressorgens und des von ihm kodierten Proteins dargestellt . Unter Beruecksichtigung eigener Untersuchungen und der Literatur werden Haeufigkeit und Spektrum somatischer p53-Mutationen in der Kanzerogenese des Mammakarzinoms , des kolorektalen Karzinoms , des Magenkarzinoms , des hepatozellulaeren Karzinoms , des Plattenepithelkarzinoms der Haut sowie des malignen Melanoms diskutiert .
DerPathologe.60170181.ger.abstr-s1-r1-t2.1-t1.1
result_of
DerPathologe.60170181.ger.abstr-s4-t2
DerPathologe.60170181.ger.abstr-s4-t1
DerPathologe.60170181.ger.abstr-s1-r2-t2.1-t1.1
degree_of
DerPathologe.60170181.ger.abstr-s4-t2
DerPathologe.60170181.ger.abstr-s4-t1
DerPathologe.60170181.ger.abstr-s1-r3-t1.1-t2.1
result_of
DerPathologe.60170181.ger.abstr-s4-t1
DerPathologe.60170181.ger.abstr-s4-t2
DerPathologe.60170181.ger.abstr-s1-r4-t1.1-t2.1
degree_of
DerPathologe.60170181.ger.abstr-s4-t1
DerPathologe.60170181.ger.abstr-s4-t2
DerPathologe.60170181.ger.abstr-s2-r1-t1.1-t3.1
issue_in
DerPathologe.60170181.ger.abstr-s4-t1
DerPathologe.60170181.ger.abstr-s4-t3
DerPathologe.60170181.ger.abstr-s2-r2-t1.1-t1.2
causes
DerPathologe.60170181.ger.abstr-s4-t1
DerPathologe.60170181.ger.abstr-s2-t1
DerPathologe.60170181.ger.abstr-s2-r3-t1.2-t3.1
issue_in
DerPathologe.60170181.ger.abstr-s2-t1
DerPathologe.60170181.ger.abstr-s4-t3
DerPathologe.60170181.ger.abstr-s2-r4-t1.2-t1.1
affects
DerPathologe.60170181.ger.abstr-s2-t1
DerPathologe.60170181.ger.abstr-s4-t1
DerPathologe.60170181.ger.abstr-s4-r1-t11.1-t6.1
associated_with
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t6
DerPathologe.60170181.ger.abstr-s4-r2-t11.1-t7.1
location_of
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t7
DerPathologe.60170181.ger.abstr-s4-r3-t11.1-t9.1
surrounds
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-r4-t11.1-t4.1
associated_with
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t4
DerPathologe.60170181.ger.abstr-s4-r5-t9.1-t4.1
location_of
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-t4
DerPathologe.60170181.ger.abstr-s4-r6-t9.1-t5.1
developmental_form_of
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-t5
DerPathologe.60170181.ger.abstr-s4-r7-t11.1-t3.1
associated_with
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t3
DerPathologe.60170181.ger.abstr-s4-r8-t11.1-t6.1
location_of
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t6
DerPathologe.60170181.ger.abstr-s4-r9-t11.1-t2.1
associated_with
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t2
DerPathologe.60170181.ger.abstr-s4-r10-t8.1-t6.1
treats
DerPathologe.60170181.ger.abstr-s4-t8
DerPathologe.60170181.ger.abstr-s4-t6
DerPathologe.60170181.ger.abstr-s4-r11-t8.1-t3.1
treats
DerPathologe.60170181.ger.abstr-s4-t8
DerPathologe.60170181.ger.abstr-s4-t3
DerPathologe.60170181.ger.abstr-s4-r12-t9.1-t11.1
conceptual_part_of
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-r13-t5.1-t13.1
location_of
DerPathologe.60170181.ger.abstr-s4-t5
DerPathologe.60170181.ger.abstr-s4-t13
DerPathologe.60170181.ger.abstr-s4-r14-t9.1-t3.1
location_of
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-t3
DerPathologe.60170181.ger.abstr-s4-r15-t5.1-t11.1
conceptual_part_of
DerPathologe.60170181.ger.abstr-s4-t5
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-r16-t5.1-t12.1
location_of
DerPathologe.60170181.ger.abstr-s4-t5
DerPathologe.60170181.ger.abstr-s4-t12
DerPathologe.60170181.ger.abstr-s4-r17-t9.1-t2.1
location_of
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-t2
DerPathologe.60170181.ger.abstr-s4-r18-t11.1-t13.1
associated_with
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t13
DerPathologe.60170181.ger.abstr-s4-r19-t11.1-t4.1
location_of
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t4
DerPathologe.60170181.ger.abstr-s4-r20-t8.1-t13.1
treats
DerPathologe.60170181.ger.abstr-s4-t8
DerPathologe.60170181.ger.abstr-s4-t13
DerPathologe.60170181.ger.abstr-s4-r21-t5.1-t9.1
surrounds
DerPathologe.60170181.ger.abstr-s4-t5
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-r22-t8.1-t10.1
treats
DerPathologe.60170181.ger.abstr-s4-t8
DerPathologe.60170181.ger.abstr-s4-t10
DerPathologe.60170181.ger.abstr-s4-r23-t11.1-t12.1
associated_with
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t12
DerPathologe.60170181.ger.abstr-s4-r24-t5.1-t7.1
location_of
DerPathologe.60170181.ger.abstr-s4-t5
DerPathologe.60170181.ger.abstr-s4-t7
DerPathologe.60170181.ger.abstr-s4-r25-t11.1-t10.1
associated_with
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t10
DerPathologe.60170181.ger.abstr-s4-r26-t11.1-t3.1
location_of
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t3
DerPathologe.60170181.ger.abstr-s4-r27-t5.1-t10.1
location_of
DerPathologe.60170181.ger.abstr-s4-t5
DerPathologe.60170181.ger.abstr-s4-t10
DerPathologe.60170181.ger.abstr-s4-r28-t5.1-t6.1
location_of
DerPathologe.60170181.ger.abstr-s4-t5
DerPathologe.60170181.ger.abstr-s4-t6
DerPathologe.60170181.ger.abstr-s4-r29-t8.1-t7.1
treats
DerPathologe.60170181.ger.abstr-s4-t8
DerPathologe.60170181.ger.abstr-s4-t7
DerPathologe.60170181.ger.abstr-s4-r30-t9.1-t11.1
developmental_form_of
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-r31-t11.1-t2.1
location_of
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t2
DerPathologe.60170181.ger.abstr-s4-r32-t8.1-t4.1
treats
DerPathologe.60170181.ger.abstr-s4-t8
DerPathologe.60170181.ger.abstr-s4-t4
DerPathologe.60170181.ger.abstr-s4-r33-t11.1-t13.1
location_of
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t13
DerPathologe.60170181.ger.abstr-s4-r34-t11.1-t12.1
location_of
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t12
DerPathologe.60170181.ger.abstr-s4-r35-t5.1-t4.1
location_of
DerPathologe.60170181.ger.abstr-s4-t5
DerPathologe.60170181.ger.abstr-s4-t4
DerPathologe.60170181.ger.abstr-s4-r36-t9.1-t13.1
location_of
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-t13
DerPathologe.60170181.ger.abstr-s4-r37-t5.1-t3.1
location_of
DerPathologe.60170181.ger.abstr-s4-t5
DerPathologe.60170181.ger.abstr-s4-t3
DerPathologe.60170181.ger.abstr-s4-r38-t9.1-t12.1
location_of
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-t12
DerPathologe.60170181.ger.abstr-s4-r39-t11.1-t10.1
location_of
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t10
DerPathologe.60170181.ger.abstr-s4-r40-t9.1-t7.1
location_of
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-t7
DerPathologe.60170181.ger.abstr-s4-r41-t8.1-t2.1
treats
DerPathologe.60170181.ger.abstr-s4-t8
DerPathologe.60170181.ger.abstr-s4-t2
DerPathologe.60170181.ger.abstr-s4-r42-t5.1-t2.1
location_of
DerPathologe.60170181.ger.abstr-s4-t5
DerPathologe.60170181.ger.abstr-s4-t2
DerPathologe.60170181.ger.abstr-s4-r43-t9.1-t6.1
location_of
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-t6
DerPathologe.60170181.ger.abstr-s4-r44-t9.1-t10.1
location_of
DerPathologe.60170181.ger.abstr-s4-t9
DerPathologe.60170181.ger.abstr-s4-t10
DerPathologe.60170181.ger.abstr-s4-r45-t11.1-t7.1
associated_with
DerPathologe.60170181.ger.abstr-s4-t11
DerPathologe.60170181.ger.abstr-s4-t7
DerPathologe.60170181.ger.abstr-s4-r46-t8.1-t12.1
treats
DerPathologe.60170181.ger.abstr-s4-t8
DerPathologe.60170181.ger.abstr-s4-t12