DerAnaesthesist.60450255.ger.abstr-passage-0
abstract
Thrombozyten tragen 2-Rezeptoren auf der Zelloberflaeche , deren Stimulation die Thrombozytenaggregation ausloest . Die vorliegende Untersuchung ging der Frage nach , ob 2-Agonisten die Dichte thrombozytaerer 2-Rezeptoren vermindern und hierueber die Thrombozytenaggregation beeintraechtigen . Venoese Blutproben von 20 gesunden Probanden wurden ueber 24 h in vitro mit Clonidin und Dexmedetomidin inkubiert . Die Epinephrin- und Kollagen-induzierte Thrombozytenaggregation wurde mit Hilfe der Turbidometrie und die Dichte der thrombozytaeren 2-Rezeptoren in Radioliganden-Bindungsstudien mit3H-Yohimbin gemessen . Die klinisch relevanten Konzentrationen von 1 ng/ml Clonidin bzw. Dexmedetomidin fuehrten zu keinen signifikanten Veraenderungen der Thrombozytenaggregation oder der 2-Rezeptoren-Dichte. 10 ng/ml Dexmedetomidin verursachten eine signifikante ( p 0,05 ) Abnahme der Epinephrin-induzierten Thrombozytenaggregation ( 16,0 +/- 5,4% , n=20, Mittelwert +/- SEM ) verglichen mit der Kontrollprobe ( 46,0 +/- 1,3% , n=20). Fuer die 2-Rezeptorendichte ergaben sich keine signifikanten Unterschiede zur Kontrollprobe . Dieses Ergebnis zeigte , dass eine Desensitivierung der Epinephrin-induzierten Thrombozytenaggregation ohne quantitative Veraenderung der 2-Rezeptoren auftreten kann .
DerAnaesthesist.60450255.ger.abstr-s1-r1-t1.1-t3.1
adjacent_to
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s1-r2-t1.1-t2.1
location_of
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s6-t2
DerAnaesthesist.60450255.ger.abstr-s1-r3-t3.1-t1.1
adjacent_to
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s1-r4-t3.1-t2.1
location_of
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s6-t2
DerAnaesthesist.60450255.ger.abstr-s2-r1-t2.1-t1.1
location_of
DerAnaesthesist.60450255.ger.abstr-s6-t2
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s3-r1-t2.1-t3.1
interacts_with
DerAnaesthesist.60450255.ger.abstr-s6-t2
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s3-r2-t1.1-t3.1
analyzes
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s3-r3-t1.1-t2.1
analyzes
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s6-t2
DerAnaesthesist.60450255.ger.abstr-s3-r4-t3.1-t2.1
interacts_with
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s6-t2
DerAnaesthesist.60450255.ger.abstr-s3-r5-t4.1-t1.1
evaluation_of
DerAnaesthesist.60450255.ger.abstr-s5-t4
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s4-r1-t1.1-t2.1
affects
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s6-t2
DerAnaesthesist.60450255.ger.abstr-s4-r2-t2.1-t1.1
produces
DerAnaesthesist.60450255.ger.abstr-s6-t2
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s4-r3-t1.1-t3.1
disrupts
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s4-r4-t3.1-t1.1
produces
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s4-r5-t3.1-t2.1
location_of
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s6-t2
DerAnaesthesist.60450255.ger.abstr-s5-r1-t6.1-t3.1
interacts_with
DerAnaesthesist.60450255.ger.abstr-s5-t6
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s5-r2-t4.1-t1.1
result_of
DerAnaesthesist.60450255.ger.abstr-s5-t4
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-r3-t3.1-t4.1
affects
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s5-t4
DerAnaesthesist.60450255.ger.abstr-s5-r4-t6.1-t1.1
interacts_with
DerAnaesthesist.60450255.ger.abstr-s5-t6
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-r5-t1.1-t5.1
disrupts
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-t5
DerAnaesthesist.60450255.ger.abstr-s5-r6-t6.1-t4.1
affects
DerAnaesthesist.60450255.ger.abstr-s5-t6
DerAnaesthesist.60450255.ger.abstr-s5-t4
DerAnaesthesist.60450255.ger.abstr-s5-r7-t5.1-t8.1
adjacent_to
DerAnaesthesist.60450255.ger.abstr-s5-t5
DerAnaesthesist.60450255.ger.abstr-s5-t8
DerAnaesthesist.60450255.ger.abstr-s5-r8-t1.1-t3.1
interacts_with
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s5-r9-t8.1-t1.1
location_of
DerAnaesthesist.60450255.ger.abstr-s5-t8
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-r10-t3.1-t5.1
disrupts
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s5-t5
DerAnaesthesist.60450255.ger.abstr-s5-r11-t5.1-t6.1
produces
DerAnaesthesist.60450255.ger.abstr-s5-t5
DerAnaesthesist.60450255.ger.abstr-s5-t6
DerAnaesthesist.60450255.ger.abstr-s5-r12-t5.1-t7.1
location_of
DerAnaesthesist.60450255.ger.abstr-s5-t5
DerAnaesthesist.60450255.ger.abstr-s5-t7
DerAnaesthesist.60450255.ger.abstr-s5-r13-t8.1-t3.1
produces
DerAnaesthesist.60450255.ger.abstr-s5-t8
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s5-r14-t1.1-t4.1
result_of
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-t4
DerAnaesthesist.60450255.ger.abstr-s5-r15-t1.1-t7.1
affects
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-t7
DerAnaesthesist.60450255.ger.abstr-s5-r16-t6.1-t8.1
disrupts
DerAnaesthesist.60450255.ger.abstr-s5-t6
DerAnaesthesist.60450255.ger.abstr-s5-t8
DerAnaesthesist.60450255.ger.abstr-s5-r17-t3.1-t1.1
affects
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-r18-t1.1-t7.1
result_of
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-t7
DerAnaesthesist.60450255.ger.abstr-s5-r19-t3.1-t7.1
affects
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s5-t7
DerAnaesthesist.60450255.ger.abstr-s5-r20-t1.1-t6.1
interacts_with
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-t6
DerAnaesthesist.60450255.ger.abstr-s5-r21-t5.1-t4.1
location_of
DerAnaesthesist.60450255.ger.abstr-s5-t5
DerAnaesthesist.60450255.ger.abstr-s5-t4
DerAnaesthesist.60450255.ger.abstr-s5-r22-t3.1-t1.1
interacts_with
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-r23-t6.1-t1.1
affects
DerAnaesthesist.60450255.ger.abstr-s5-t6
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-r24-t8.1-t1.1
produces
DerAnaesthesist.60450255.ger.abstr-s5-t8
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-r25-t8.1-t7.1
location_of
DerAnaesthesist.60450255.ger.abstr-s5-t8
DerAnaesthesist.60450255.ger.abstr-s5-t7
DerAnaesthesist.60450255.ger.abstr-s5-r26-t5.1-t3.1
produces
DerAnaesthesist.60450255.ger.abstr-s5-t5
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s5-r27-t1.1-t8.1
disrupts
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-t8
DerAnaesthesist.60450255.ger.abstr-s5-r28-t6.1-t7.1
affects
DerAnaesthesist.60450255.ger.abstr-s5-t6
DerAnaesthesist.60450255.ger.abstr-s5-t7
DerAnaesthesist.60450255.ger.abstr-s5-r29-t7.1-t1.1
result_of
DerAnaesthesist.60450255.ger.abstr-s5-t7
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-r30-t3.1-t8.1
disrupts
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s5-t8
DerAnaesthesist.60450255.ger.abstr-s5-r31-t8.1-t5.1
adjacent_to
DerAnaesthesist.60450255.ger.abstr-s5-t8
DerAnaesthesist.60450255.ger.abstr-s5-t5
DerAnaesthesist.60450255.ger.abstr-s5-r32-t3.1-t6.1
interacts_with
DerAnaesthesist.60450255.ger.abstr-s5-t3
DerAnaesthesist.60450255.ger.abstr-s5-t6
DerAnaesthesist.60450255.ger.abstr-s5-r33-t5.1-t1.1
location_of
DerAnaesthesist.60450255.ger.abstr-s5-t5
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-r34-t6.1-t5.1
disrupts
DerAnaesthesist.60450255.ger.abstr-s5-t6
DerAnaesthesist.60450255.ger.abstr-s5-t5
DerAnaesthesist.60450255.ger.abstr-s5-r35-t8.1-t6.1
produces
DerAnaesthesist.60450255.ger.abstr-s5-t8
DerAnaesthesist.60450255.ger.abstr-s5-t6
DerAnaesthesist.60450255.ger.abstr-s5-r36-t1.1-t4.1
affects
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s5-t4
DerAnaesthesist.60450255.ger.abstr-s5-r37-t8.1-t4.1
location_of
DerAnaesthesist.60450255.ger.abstr-s5-t8
DerAnaesthesist.60450255.ger.abstr-s5-t4
DerAnaesthesist.60450255.ger.abstr-s5-r38-t5.1-t1.1
produces
DerAnaesthesist.60450255.ger.abstr-s5-t5
DerAnaesthesist.60450255.ger.abstr-s6-t1
DerAnaesthesist.60450255.ger.abstr-s6-r1-t2.1-t1.1
location_of
DerAnaesthesist.60450255.ger.abstr-s6-t2
DerAnaesthesist.60450255.ger.abstr-s6-t1