DerChirurg.60671016.ger.abstr-passage-0
abstract
Zusammenfassung . Die Osteomyelofibrose ( OMF ) ist eine myeloproliferative Erkrankung , bei der es durch Fibrosierung und Sklerosierung zu einer Veroedung des Knochenmarks kommt . Kompensatorisch findet in Leber und Milz extramedullaere Haematopoese statt . Die resultierende Splenomegalie kann ihrerseits durch lokale Kompression , Thrombocytopenie und haemolytische Anaemie zu bedrohlichen Symptomen fuehren . Die Splenektomie ist bei diesen Patienten trotz ihrer Risiken die einzig erfolgversprechende Therapie .
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