HNO.90470723.ger.abstr-passage-0
abstract
Tenascin , ein Glykoprotein der extrazellulaeren Matrix ( EZM ) , ist aufgrund seiner proliferations- und migrationsassoziierten Expression ein Zielmolekuel in der intralaesionalen Glioblastomtherapie . Ob dieses Konzept auf Plattenepithelkarzinome des oberen Aerodigestivtraktes uebertragbar ist , haengt wesentlich vom Tenascinexpressionsmuster in diesen Tumoren ab . Unser Ziel war es zu klaeren , von welchen Zellen und wie selektiv Tenascin exprimiert wird und ob ein Zusammenhang mit dem Tumorstadium besteht . Die Tenascinexpression wurde immunhistochemisch und ueber In-situ-Hybridisierung an Nativgeweben von Primaertumoren und Lymphknotenmetastasen ( n=39) sowie an Tumorzellkulturen ( n=15) untersucht . Die so erhaltenen Expressionsmuster wurden denen der Normalschleimhaut gegenuebergestellt . Tenascin wurde in Tumoren verstaerkt exprimiert und war in der gesamten tumorumgebenden EZM lokalisiert . Die mRNA-Analyse am Gewebeschnitt und die Proteinanalyse der Tumorzellkulturen ergab , dass die Tumorzellen selbst Tenascin synthetisierten . Ein Zusammenhang von Tenascinexpression und TNM-Stadium oder Tumorproliferation war nicht nachweisbar . Unsere Ergebnisse zeigen , dass Tenascin in Kopf-Hals-Tumoren selektiv exprimiert wird und sich fuer eine gezielte , onkologische Therapie anbietet .
HNO.90470723.ger.abstr-s2-r1-t1.1-t4.1
treats
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s2-r2-t4.1-t2.1
produces
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s2-r3-t2.1-t3.1
location_of
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s2-r4-t1.1-t3.1
treats
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s2-r5-t2.1-t4.1
location_of
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s2-r6-t3.1-t2.1
produces
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s3-r1-t2.1-t1.1
disrupts
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s3-r2-t2.1-t3.1
affects
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s3-r3-t1.1-t3.1
location_of
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s3-r4-t3.1-t2.1
produces
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s3-r5-t1.1-t2.1
produces
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s4-r1-t3.1-t2.1
surrounds
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s4-r2-t4.1-t2.1
produces
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s4-r3-t3.1-t4.2
adjacent_to
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s4-t4
HNO.90470723.ger.abstr-s4-r4-t2.1-t4.2
surrounds
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s4-t4
HNO.90470723.ger.abstr-s4-r5-t4.1-t1.1
associated_with
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s4-r6-t2.1-t4.1
location_of
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s4-r7-t2.1-t3.1
developmental_form_of
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s4-r8-t4.2-t4.1
location_of
HNO.90470723.ger.abstr-s4-t4
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s4-r9-t4.2-t2.1
part_of
HNO.90470723.ger.abstr-s4-t4
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s4-r10-t1.1-t4.1
associated_with
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s4-r11-t4.2-t3.1
adjacent_to
HNO.90470723.ger.abstr-s4-t4
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s4-r12-t3.1-t4.1
location_of
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s6-r1-t1.1-t2.1
affects
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s6-r2-t2.1-t1.1
produces
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s6-r3-t3.1-t1.1
produces
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s6-r4-t1.1-t3.1
affects
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s7-r1-t3.1-t7.1
produces
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s7-t7
HNO.90470723.ger.abstr-s7-r2-t2.1-t6.1
disrupts
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t6
HNO.90470723.ger.abstr-s7-r3-t3.1-t2.1
analyzes
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s7-r4-t7.1-t1.1
disrupts
HNO.90470723.ger.abstr-s7-t7
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s7-r5-t7.1-t5.1
affects
HNO.90470723.ger.abstr-s7-t7
HNO.90470723.ger.abstr-s9-t5
HNO.90470723.ger.abstr-s7-r6-t1.1-t2.1
produces
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s7-r7-t1.1-t5.1
location_of
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-t5
HNO.90470723.ger.abstr-s7-r8-t5.1-t7.1
produces
HNO.90470723.ger.abstr-s9-t5
HNO.90470723.ger.abstr-s7-t7
HNO.90470723.ger.abstr-s7-r9-t5.1-t3.1
associated_with
HNO.90470723.ger.abstr-s9-t5
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s7-r10-t6.1-t5.1
location_of
HNO.90470723.ger.abstr-s9-t6
HNO.90470723.ger.abstr-s9-t5
HNO.90470723.ger.abstr-s7-r11-t6.1-t7.1
produces
HNO.90470723.ger.abstr-s9-t6
HNO.90470723.ger.abstr-s7-t7
HNO.90470723.ger.abstr-s7-r12-t3.1-t2.1
produces
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s7-r13-t2.1-t7.1
interacts_with
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s7-t7
HNO.90470723.ger.abstr-s7-r14-t7.1-t2.1
interacts_with
HNO.90470723.ger.abstr-s7-t7
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s7-r15-t1.1-t3.1
surrounds
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s7-r16-t3.1-t5.1
associated_with
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t5
HNO.90470723.ger.abstr-s7-r17-t3.1-t1.1
part_of
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s7-r18-t2.1-t1.1
disrupts
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s7-r19-t3.1-t7.1
measures
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s7-t7
HNO.90470723.ger.abstr-s7-r20-t7.1-t3.1
disrupts
HNO.90470723.ger.abstr-s7-t7
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s7-r21-t5.1-t2.1
produces
HNO.90470723.ger.abstr-s9-t5
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s7-r22-t3.1-t5.1
location_of
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t5
HNO.90470723.ger.abstr-s7-r23-t2.1-t5.1
affects
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t5
HNO.90470723.ger.abstr-s7-r24-t1.1-t6.1
surrounds
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-t6
HNO.90470723.ger.abstr-s7-r25-t3.1-t7.1
analyzes
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s7-t7
HNO.90470723.ger.abstr-s7-r26-t7.1-t6.1
disrupts
HNO.90470723.ger.abstr-s7-t7
HNO.90470723.ger.abstr-s9-t6
HNO.90470723.ger.abstr-s7-r27-t1.1-t7.1
produces
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s7-t7
HNO.90470723.ger.abstr-s7-r28-t6.1-t1.1
part_of
HNO.90470723.ger.abstr-s9-t6
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s7-r29-t6.1-t2.1
produces
HNO.90470723.ger.abstr-s9-t6
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s7-r30-t5.1-t1.1
produces
HNO.90470723.ger.abstr-s9-t5
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s7-r31-t3.1-t2.1
measures
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s7-r32-t2.1-t3.1
disrupts
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-r1-t2.1-t6.1
location_of
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t6
HNO.90470723.ger.abstr-s9-r2-t3.1-t6.1
location_of
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t6
HNO.90470723.ger.abstr-s9-r3-t6.1-t4.1
associated_with
HNO.90470723.ger.abstr-s9-t6
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s9-r4-t2.1-t4.1
location_of
HNO.90470723.ger.abstr-s9-t2
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s9-r5-t4.1-t6.1
associated_with
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s9-t6
HNO.90470723.ger.abstr-s9-r6-t4.1-t1.1
produces
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-r7-t3.1-t4.1
location_of
HNO.90470723.ger.abstr-s9-t3
HNO.90470723.ger.abstr-s9-t4
HNO.90470723.ger.abstr-s9-r8-t1.1-t4.1
affects
HNO.90470723.ger.abstr-s9-t1
HNO.90470723.ger.abstr-s9-t4