HNO.70450630.ger.abstr-passage-0
abstract
Das Cholesteatom ist durch das Einwachsen verhornenden Plattenepithels in das Mittelohr charakterisiert . Um das Verhalten beider Epithelien zu beschreiben , wurden 50 Cholesteatompraeparate mit Mittelohrschleimhautanteilen immunhistochemisch auf die Expression und Lokalisation von Interleukin-1 ( Il-1), " transforming growth factor- " ( TGF- ) , " epidermal growth factor " ( EGF ) , " epidermal growth factor-receptor " ( EGF-R ) , des Proliferationsmarkers MIB 1 , des Protoonkogenprodukts c-myc und des Aktivierungsmarkers 4F2 vergleichend untersucht . Die Keratinozyten des Cholesteatoms besassen eine deutlich hoehere Aktivierungs- und Proliferationsrate als die Mittelohrschleimhautzellen . Die Epithelzellen der Mittelohrmukosa zeigten immunhistochemisch keine Expression von TGF- , EGF-R , Il-1 und c-myc , im Gegensatz zur deutlichen Immunreaktivitaet der Cholesteatommatrix . Die lokale Freisetzung von Zytokinen und Wachstumsfaktoren , wie TGF- , EGF und Il-1 aus Zellen des entzuendlichen Infiltrats der Perimatrix , scheinen fuer das hyperproliferative Wachstumsverhalten der Cholesteatommatrix von besonderer Bedeutung zu sein . Die Ergebnisse koennen als Erklaerungsansatz fuer das Fortschreiten des Cholesteatomwachstums unter Verdraengung der Mittelohrschleimhaut dienen .
HNO.70450630.ger.abstr-s1-r1-t2.1-t1.1
treats
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s1-r2-t1.1-t3.1
produces
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s1-r3-t3.1-t1.1
location_of
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s2-r1-t3.1-t4.1
interacts_with
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s5-t4
HNO.70450630.ger.abstr-s2-r2-t2.1-t3.1
produces
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s2-r3-t3.1-t2.1
disrupts
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s2-r4-t4.1-t3.1
interacts_with
HNO.70450630.ger.abstr-s5-t4
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s2-r5-t4.1-t2.1
disrupts
HNO.70450630.ger.abstr-s5-t4
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s2-r6-t2.1-t4.1
produces
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s5-t4
HNO.70450630.ger.abstr-s3-r1-t1.1-t2.1
part_of
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s3-r2-t2.1-t3.1
surrounds
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s3-r3-t2.1-t1.1
surrounds
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s3-r4-t3.1-t2.1
part_of
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s5-r1-t2.1-t4.1
affects
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s5-t4
HNO.70450630.ger.abstr-s5-r2-t4.1-t2.1
produces
HNO.70450630.ger.abstr-s5-t4
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s5-r3-t1.1-t2.1
interacts_with
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s5-r4-t3.1-t1.1
produces
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s5-r5-t4.1-t1.1
produces
HNO.70450630.ger.abstr-s5-t4
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s5-r6-t1.1-t3.1
disrupts
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s5-r7-t3.1-t4.1
location_of
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s5-t4
HNO.70450630.ger.abstr-s5-r8-t3.1-t2.1
produces
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s5-r9-t1.1-t4.1
affects
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s5-t4
HNO.70450630.ger.abstr-s5-r10-t2.1-t3.1
disrupts
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s5-r11-t2.1-t1.1
interacts_with
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s6-r1-t2.1-t1.1
degree_of
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s6-r2-t1.1-t2.1
degree_of
HNO.70450630.ger.abstr-s6-t1
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s6-r3-t3.1-t2.1
location_of
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s6-t2
HNO.70450630.ger.abstr-s6-r4-t3.1-t1.1
location_of
HNO.70450630.ger.abstr-s6-t3
HNO.70450630.ger.abstr-s6-t1