HNO.90470879.ger.abstr-passage-0
abstract
Maligne Hirntumoren und Mammakarzinome koennen durch die Abgabe der Zytokine " transforming growth factor " ( TGF- ) und Interleukin 10 Il-10) ( die koerpereigene zellulaere Immunantwort unterdruecken . Wir untersuchten , ob TGF-2 und Il-10 auch in Plattenepithelkarzinomen des Kopf-Hals-Bereichs nachweisbar sind und inwieweit sich die Expression im Gewebe mit dem Tumorstadium und den praetherapeutischen Serumwerten beider Zytokine korrelieren laesst . In Tumorgeweben von Patienten mit Kopf-Hals-Tumoren ( n=21) wurde immunhistochemisch TGF-2 in 95% und Il-10 in 79% nachgewiesen . TGF-2 war vor allem in den Tumorzellen und an der Tumor-Stroma-Grenze nachweisbar Il-10 , vermehrt im peritumoralen Bindegewebe . Bei 49 Patienten wurden praetherapeutisch mittels Elisa die TGF-2- und Il-10-Serumspiegel bestimmt . Vor allem metastasierende Tumoren zeigten praeoperativ erhoehte Serumwerte . Die Zytokinexpression des Tumorgewebes zeigte keine generelle Uebereinstimmung mit den praetherapeutischen Serumwerten . Wir konnten zeigen , dass die Mehrheit der untersuchten HNO-Tumoren immunsuppressive Faktoren exprimieren , und dass die praetherapeutischen Il-10- und TGF-2-Serumspiegel mit einem fortgeschrittenen Tumorstadium einhergehen .
HNO.90470879.ger.abstr-s1-r1-t2.1-t3.1
produces
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s1-r2-t3.1-t4.1
interacts_with
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s1-r3-t4.1-t2.1
indicates
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s1-r4-t3.1-t1.1
affects
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s1-r5-t1.1-t4.1
produces
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s1-r6-t3.1-t1.1
indicates
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s1-r7-t4.1-t1.1
affects
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s1-r8-t2.1-t4.1
produces
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s1-r9-t3.1-t2.1
affects
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s1-r10-t4.1-t1.1
indicates
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s1-r11-t4.1-t2.1
affects
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s1-r12-t3.1-t2.1
indicates
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s1-r13-t1.1-t3.1
produces
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s1-r14-t4.1-t3.1
interacts_with
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s2-r1-t2.1-t7.1
location_of
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s2-t7
HNO.90470879.ger.abstr-s2-r2-t6.1-t8.1
produces
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s2-t8
HNO.90470879.ger.abstr-s2-r3-t7.1-t8.1
produces
HNO.90470879.ger.abstr-s2-t7
HNO.90470879.ger.abstr-s2-t8
HNO.90470879.ger.abstr-s2-r4-t4.1-t3.1
location_of
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s2-r5-t3.1-t6.1
produces
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s2-r6-t3.1-t2.1
produces
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s2-r7-t8.1-t7.1
indicates
HNO.90470879.ger.abstr-s2-t8
HNO.90470879.ger.abstr-s2-t7
HNO.90470879.ger.abstr-s2-r8-t8.1-t3.1
indicates
HNO.90470879.ger.abstr-s2-t8
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s2-r9-t4.1-t2.1
location_of
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s2-r10-t1.1-t7.1
treats
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s2-t7
HNO.90470879.ger.abstr-s2-r11-t5.1-t3.1
location_of
HNO.90470879.ger.abstr-s3-t5
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s2-r12-t4.1-t7.1
location_of
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s2-t7
HNO.90470879.ger.abstr-s2-r13-t2.1-t8.1
produces
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s2-t8
HNO.90470879.ger.abstr-s2-r14-t8.1-t7.1
affects
HNO.90470879.ger.abstr-s2-t8
HNO.90470879.ger.abstr-s2-t7
HNO.90470879.ger.abstr-s2-r15-t5.1-t2.1
location_of
HNO.90470879.ger.abstr-s3-t5
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s2-r16-t4.1-t6.1
location_of
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s2-r17-t6.1-t3.1
location_of
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s2-r18-t5.1-t7.1
location_of
HNO.90470879.ger.abstr-s3-t5
HNO.90470879.ger.abstr-s2-t7
HNO.90470879.ger.abstr-s2-r19-t3.1-t8.1
produces
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s2-t8
HNO.90470879.ger.abstr-s2-r20-t7.1-t6.1
produces
HNO.90470879.ger.abstr-s2-t7
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s2-r21-t2.1-t3.1
location_of
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s2-r22-t8.1-t6.1
disrupts
HNO.90470879.ger.abstr-s2-t8
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s2-r23-t1.1-t3.1
treats
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s2-r24-t8.1-t3.1
affects
HNO.90470879.ger.abstr-s2-t8
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s2-r25-t5.1-t6.1
location_of
HNO.90470879.ger.abstr-s3-t5
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s2-r26-t7.1-t2.1
produces
HNO.90470879.ger.abstr-s2-t7
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s2-r27-t6.1-t7.1
location_of
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s2-t7
HNO.90470879.ger.abstr-s2-r28-t8.1-t2.1
disrupts
HNO.90470879.ger.abstr-s2-t8
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s3-r1-t1.1-t2.1
produces
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s3-r2-t2.1-t1.1
location_of
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s3-r3-t2.1-t6.1
location_of
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s3-r4-t6.1-t3.1
occurs_in
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s3-r5-t4.1-t2.1
location_of
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s3-r6-t1.1-t3.1
occurs_in
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s3-r7-t4.1-t1.1
location_of
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s3-r8-t5.1-t2.1
location_of
HNO.90470879.ger.abstr-s3-t5
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s3-r9-t4.1-t6.1
location_of
HNO.90470879.ger.abstr-s3-t4
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s3-r10-t6.1-t2.1
produces
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s3-r11-t5.1-t1.1
location_of
HNO.90470879.ger.abstr-s3-t5
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s3-r12-t5.1-t6.1
location_of
HNO.90470879.ger.abstr-s3-t5
HNO.90470879.ger.abstr-s3-t6
HNO.90470879.ger.abstr-s4-r1-t3.1-t2.1
surrounds
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s4-r2-t2.1-t1.1
location_of
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s4-r3-t3.1-t1.1
location_of
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s4-r4-t2.1-t3.1
part_of
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s4-r5-t1.1-t3.1
produces
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s4-t3
HNO.90470879.ger.abstr-s7-r1-t1.1-t2.1
produces
HNO.90470879.ger.abstr-s8-t1
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s7-r2-t2.1-t1.1
location_of
HNO.90470879.ger.abstr-s7-t2
HNO.90470879.ger.abstr-s8-t1