DerAnaesthesist.7046s047.ger.abstr-passage-0
abstract
Zentrale Problematik zellulaerer Neuroprotektion ist die Applikation von Substanzen , die nach neurotoxischer Schaedigung in klinischer Dosierung Neurone und Astroglia zu schuetzen vermoegen . Spezielle Bedeutung hat der N-Methyl-D-Aspartat ( NMDA ) -Antagonist Ketamin , der durch Blockade einer exzessiven NMDA-Rezeptor-Stimulation eine intrazellulaere Kalziumueberladung oder pathologische NO-Produktion und damit den konsekutiven Zelltod reduzieren koennte . Nach anoxisch-ischaemischen sowie durch Glutamat-ausgeloesten Schaedigungen wurde bei Neuronen und Gliazellen ermittelt , dass Ketamin-Razemat konzentrationsabhaengig eine hoehere Viabilitaet , eine intakte Zellmorphologie sowie reduzierte Zellschwellungsphaenomene induzierte . Der energetische Status geschaedigter Neurone war nach Ketamintherapie verbessert und funktionell-elektrophysiologische Ablaeufe zeigten sich durch Stabilisierung der intrazellulaeren Ionenhomoeostase reguliert . Ketamin beeintraechtigte die Induktion intrinsisch-protektiver Wachstumsfaktoren bei geschaedigten Neuronen nicht und S- ( + ) -Ketamin , das rechtsdrehende Isomer des razemischen Ketamin , demonstrierte neben maximal neuroprotektiven Effekten bei geschaedigten hippokampalen Neuronenkulturen einzigartig ein neuroregeneratives Potential . Dies zeigte sich in groesserem Wiederaussprossen von geschaedigten Axonen und der verstaerkten Expression des Wachstums-assoziierten Proteins . Hierzu vorstellbar ist , dass Ketamin durch Beeinflussung von Signaltransduktionsmechanismen , die bei der NMDA-Rezeptoraktivierung die Genexpression in Neuronen regulieren , ueber die Induktion eines differenzierten Musters an Genen zellulaere Wachstumsvorgaenge positiv reguliert . Weiterfuehrende tierexperimentelle Studien sowie Humanuntersuchungen zu neuroprotektivem sowie neuroregenerativem Potential des Ketamin im Hinblick auf klinische Anwendung sind jedoch notwendig .
DerAnaesthesist.7046s047.ger.abstr-s2-r1-t3.1-t4.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s2-r2-t4.1-t2.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s2-r3-t1.1-t2.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s2-r4-t1.1-t5.1
affects
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-t5
DerAnaesthesist.7046s047.ger.abstr-s2-r5-t5.1-t4.1
produces
DerAnaesthesist.7046s047.ger.abstr-s7-t5
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s2-r6-t4.1-t1.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s2-r7-t2.1-t5.1
affects
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s7-t5
DerAnaesthesist.7046s047.ger.abstr-s2-r8-t3.1-t2.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s2-r9-t2.1-t4.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s2-r10-t3.1-t5.1
affects
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s7-t5
DerAnaesthesist.7046s047.ger.abstr-s2-r11-t3.1-t1.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s2-r12-t2.1-t3.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s2-r13-t4.1-t5.1
affects
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s7-t5
DerAnaesthesist.7046s047.ger.abstr-s2-r14-t1.1-t4.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s2-r15-t4.1-t3.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s2-r16-t2.1-t1.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s2-r17-t1.1-t3.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s3-r1-t2.1-t1.1
produces
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s3-r2-t1.1-t2.1
disrupts
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s3-r3-t3.1-t1.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s3-r4-t1.1-t3.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s4-r1-t1.1-t2.1
affects
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s5-r1-t4.1-t2.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s5-r2-t1.1-t2.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s5-r3-t4.1-t1.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s5-r4-t4.1-t3.1
disrupts
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s5-r5-t3.1-t1.1
produces
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s5-r6-t2.1-t4.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s5-r7-t1.1-t3.1
disrupts
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s5-r8-t3.1-t4.1
produces
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s5-r9-t1.1-t4.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s5-r10-t3.1-t2.1
produces
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s5-r11-t2.1-t3.1
disrupts
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s5-r12-t2.1-t1.1
interacts_with
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s6-r1-t2.1-t3.1
produces
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s6-r2-t1.1-t2.1
affects
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s6-r3-t3.1-t1.1
disrupts
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s6-r4-t3.1-t2.1
affects
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s6-r5-t1.1-t3.1
produces
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s7-r1-t2.1-t6.1
result_of
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s7-t6
DerAnaesthesist.7046s047.ger.abstr-s7-r2-t1.1-t2.1
affects
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s7-r3-t1.1-t4.1
disrupts
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s7-r4-t3.1-t4.1
part_of
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s7-r5-t6.1-t2.1
result_of
DerAnaesthesist.7046s047.ger.abstr-s7-t6
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s7-r6-t5.1-t6.1
affects
DerAnaesthesist.7046s047.ger.abstr-s7-t5
DerAnaesthesist.7046s047.ger.abstr-s7-t6
DerAnaesthesist.7046s047.ger.abstr-s7-r7-t3.1-t1.1
produces
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-r8-t4.1-t6.1
location_of
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s7-t6
DerAnaesthesist.7046s047.ger.abstr-s7-r9-t3.1-t2.1
affects
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s7-r10-t1.1-t5.1
disrupts
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-t5
DerAnaesthesist.7046s047.ger.abstr-s7-r11-t5.1-t4.1
part_of
DerAnaesthesist.7046s047.ger.abstr-s7-t5
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s7-r12-t1.1-t6.1
affects
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-t6
DerAnaesthesist.7046s047.ger.abstr-s7-r13-t1.1-t3.1
disrupts
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s7-r14-t4.1-t1.1
produces
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-r15-t5.1-t2.1
affects
DerAnaesthesist.7046s047.ger.abstr-s7-t5
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s7-r16-t5.1-t1.1
produces
DerAnaesthesist.7046s047.ger.abstr-s7-t5
DerAnaesthesist.7046s047.ger.abstr-s8-t1
DerAnaesthesist.7046s047.ger.abstr-s7-r17-t4.1-t2.1
location_of
DerAnaesthesist.7046s047.ger.abstr-s7-t4
DerAnaesthesist.7046s047.ger.abstr-s8-t2
DerAnaesthesist.7046s047.ger.abstr-s7-r18-t3.1-t6.1
affects
DerAnaesthesist.7046s047.ger.abstr-s7-t3
DerAnaesthesist.7046s047.ger.abstr-s7-t6