DerAnaesthesist.50440573.ger.abstr-passage-0
abstract
In einer tierexperimentellen Studie wurden 18 Laeuferschweine untersucht , von denen je 6 Tiere ( 1 Propanidid ) in Liposomendispersion ( abgekuerzt PropaLip ) , ( 2 Propanidid ) in Cremophor ( abgekuerzt PropaCrem und ( ) 3 ) Propofol erhielten . Nach Narkoseeinleitung mit 60 mg/kg PropaLip , 15 mg/kg PropaCrem bzw. 5 mg/kg Propofol wurden die Tiere intubiert , fuer die weiteren Messungen instrumentiert und in einer anschliessenden 60minuetigen Narkose untersucht . Der Anaesthetikaverbrauch betrug 16 mg/kg - h Propofol , 120 mg/kg h PropaCrem und 410 mg/kg - - h PropaLip . Trotz dieser hohen Dosierung und der damit verbundenen Volumenbelastung von 16,4 ml/kg - h war die Anaesthesiequalitaet in der PropaLip-Gruppe unbefriedigend . Bei diesen Tieren traten die ausgepraegtesten Anstiege von Herzfrequenz , HZV , Katecholamin- und Histaminspiegeln auf , weitgehend konstant blieben die genannten Parameter bei der Propofolgruppe , waehrend die PropaCrem-Tiere eine Mittelstellung einnahmen . Offenbar ist die Verfuegbarkeit von Propanidid in der Liposomenpraeparation schlechter als in der Cremophorloesung . Ein Zusammenhang der geringen Wirksamkeit mit der gezielten Aufnahme von Liposomen in die Zellen des RES , z.B. der Leber , wo Propanidid inaktiviert wird , wird diskutiert .
DerAnaesthesist.50440573.ger.abstr-s1-r1-t7.1-t5.1
disrupts
DerAnaesthesist.50440573.ger.abstr-s1-t7
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s1-r2-t4.1-t7.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s1-t7
DerAnaesthesist.50440573.ger.abstr-s1-r3-t7.1-t6.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s1-t7
DerAnaesthesist.50440573.ger.abstr-s1-t6
DerAnaesthesist.50440573.ger.abstr-s1-r4-t5.1-t3.1
part_of
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-t3
DerAnaesthesist.50440573.ger.abstr-s1-r5-t5.1-t4.1
produces
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s1-r6-t4.1-t6.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s1-t6
DerAnaesthesist.50440573.ger.abstr-s1-r7-t7.1-t5.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s1-t7
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s1-r8-t4.1-t5.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s1-r9-t5.1-t7.1
produces
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s1-t7
DerAnaesthesist.50440573.ger.abstr-s1-r10-t7.1-t4.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s1-t7
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s1-r11-t5.1-t7.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s1-t7
DerAnaesthesist.50440573.ger.abstr-s1-r12-t5.1-t2.1
part_of
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s1-r13-t5.1-t6.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s1-t6
DerAnaesthesist.50440573.ger.abstr-s1-r14-t5.1-t6.1
produces
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s1-t6
DerAnaesthesist.50440573.ger.abstr-s1-r15-t5.1-t4.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s1-r16-t4.1-t5.1
disrupts
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s1-r17-t6.1-t7.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s1-t6
DerAnaesthesist.50440573.ger.abstr-s1-t7
DerAnaesthesist.50440573.ger.abstr-s1-r18-t5.1-t1.1
part_of
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-t1
DerAnaesthesist.50440573.ger.abstr-s1-r19-t2.1-t3.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-t3
DerAnaesthesist.50440573.ger.abstr-s1-r20-t6.1-t5.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s1-t6
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s1-r21-t6.1-t5.1
disrupts
DerAnaesthesist.50440573.ger.abstr-s1-t6
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s1-r22-t6.1-t4.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s1-t6
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s1-r23-t2.1-t1.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-t1
DerAnaesthesist.50440573.ger.abstr-s4-r1-t2.1-t1.1
affects
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-t1
DerAnaesthesist.50440573.ger.abstr-s5-r1-t3.1-t2.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t3
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s5-r2-t2.1-t3.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-t3
DerAnaesthesist.50440573.ger.abstr-s6-r1-t1.1-t2.1
disrupts
DerAnaesthesist.50440573.ger.abstr-s7-t1
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s6-r2-t2.1-t1.1
produces
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-t1
DerAnaesthesist.50440573.ger.abstr-s6-r3-t1.1-t2.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t1
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s6-r4-t2.1-t1.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-t1
DerAnaesthesist.50440573.ger.abstr-s7-r1-t5.1-t4.1
disrupts
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s7-r2-t4.1-t3.1
adjacent_to
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s7-t3
DerAnaesthesist.50440573.ger.abstr-s7-r3-t5.1-t3.1
disrupts
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-t3
DerAnaesthesist.50440573.ger.abstr-s7-r4-t3.1-t2.1
produces
DerAnaesthesist.50440573.ger.abstr-s7-t3
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-r5-t2.1-t5.1
produces
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-r6-t2.1-t4.1
part_of
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s7-r7-t4.1-t2.1
produces
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-r8-t3.1-t5.1
produces
DerAnaesthesist.50440573.ger.abstr-s7-t3
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-r9-t5.1-t2.1
disrupts
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-r10-t2.1-t5.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-r11-t4.1-t5.1
produces
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-r12-t3.1-t4.1
adjacent_to
DerAnaesthesist.50440573.ger.abstr-s7-t3
DerAnaesthesist.50440573.ger.abstr-s7-t4
DerAnaesthesist.50440573.ger.abstr-s7-r13-t2.1-t3.1
part_of
DerAnaesthesist.50440573.ger.abstr-s7-t2
DerAnaesthesist.50440573.ger.abstr-s7-t3
DerAnaesthesist.50440573.ger.abstr-s7-r14-t5.1-t2.1
interacts_with
DerAnaesthesist.50440573.ger.abstr-s7-t5
DerAnaesthesist.50440573.ger.abstr-s7-t2