DerAnaesthesist.60450113.ger.abstr-passage-0
abstract
Zu den physiologischen Aufgaben der polymorphkernigen neutrophilen Leukozyten ( PMNL ) zaehlen im Rahmen der Infektabwehr die Elimination eingedrungener Mikroorganismen und bei der Wundheilung die Beseitigung von avitalem Gewebe . Hierfuer sind PMNL mit hochwirksamen mikrobiziden Mechanismen ausgestattet , deren Stimulation aber nicht nur eine Schutzfunktion erfuellt , sondern auch koerpereigenes Gewebe zerstoeren kann . Zahlreiche tierexperimentelle und klinische Befunde belegen , dass polymorphkernige neutrophile Leukozyten die alveolo-kapillaere Membran schaedigen und zur Entwicklung eines akuten Lungenversagens beitragen koennen . So sprechen der Nachweis von Aktivatoren polymorphkerniger neutrophiler Leukozyten , die Steigerung ihrer potentiell zytotoxischen Funktionen , ihre verstaerkte pulmonale Sequestration und die inverse Beziehung dieser Parameter zur Lungenfunktion bei Patienten mit ARDS fuer eine kausale Rolle von polymorphkernigen neutrophilen Leukozyten in der Pathogenese dieses Syndroms . Andererseits weist die Manifestation des akuten Lungenversagens trotz vorbestehender Leukopenie auf die Entstehung dieses Krankheitsbildes auch durch PMNL-unabhaengige Mechanismen hin . Nur auf der Grundlage einer exakten Analyse der nach Art und Dauer der ausloesenden Grunderkrankung qualitativ und quantitativ unterschiedlich ausgepraegten systemischen Entzuendungsreaktion wird es moeglich sein anti-inflammatorisch wirksame Pharmaka , gezielt einzusetzen , ohne dabei das Infektionsrisiko von Patienten mit Trauma oder Sepsis zu erhoehen .
DerAnaesthesist.60450113.ger.abstr-s1-r1-t3.1-t1.1
surrounds
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s1-r2-t1.1-t2.1
location_of
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s1-r3-t1.1-t3.1
surrounds
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s1-r4-t1.1-t3.1
part_of
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s1-r5-t3.1-t1.1
developmental_form_of
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s1-r6-t3.1-t2.1
location_of
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s3-r1-t3.1-t2.1
surrounds
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s3-r2-t3.1-t1.1
part_of
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s3-r3-t2.1-t4.1
adjacent_to
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s3-r4-t3.1-t2.1
developmental_form_of
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s3-r5-t4.1-t1.1
part_of
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s3-r6-t2.1-t3.1
surrounds
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s3-r7-t2.1-t3.1
part_of
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s3-r8-t3.1-t4.1
developmental_form_of
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s3-r9-t4.1-t2.1
adjacent_to
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s3-r10-t2.1-t1.1
part_of
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s3-r11-t4.1-t3.1
surrounds
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s4-r1-t1.1-t6.1
location_of
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s4-r2-t2.1-t7.1
location_of
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s4-t7
DerAnaesthesist.60450113.ger.abstr-s4-r3-t2.1-t1.1
adjacent_to
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s4-r4-t1.1-t5.1
adjacent_to
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s4-r5-t2.1-t6.1
location_of
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s4-r6-t3.1-t4.1
performs
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s4-r7-t6.1-t3.1
occurs_in
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s4-r8-t7.1-t6.1
result_of
DerAnaesthesist.60450113.ger.abstr-s4-t7
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s4-r9-t2.1-t5.1
adjacent_to
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s4-r10-t7.1-t3.1
occurs_in
DerAnaesthesist.60450113.ger.abstr-s4-t7
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s4-r11-t5.1-t2.1
adjacent_to
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s4-r12-t6.1-t4.1
result_of
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s4-r13-t5.1-t7.1
location_of
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s4-t7
DerAnaesthesist.60450113.ger.abstr-s4-r14-t1.1-t2.1
adjacent_to
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s4-r15-t5.1-t1.1
adjacent_to
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s4-r16-t1.1-t7.1
location_of
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s4-t7
DerAnaesthesist.60450113.ger.abstr-s4-r17-t5.1-t6.1
location_of
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s4-r18-t4.1-t3.1
associated_with
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s4-r19-t6.1-t7.1
result_of
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s4-t7
DerAnaesthesist.60450113.ger.abstr-s5-r1-t1.1-t2.1
location_of
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t2
DerAnaesthesist.60450113.ger.abstr-s6-r1-t5.1-t6.1
result_of
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-r2-t6.2-t1.1
associated_with
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-r3-t6.1-t4.1
occurs_in
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s6-r4-t4.1-t3.1
uses
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s6-t3
DerAnaesthesist.60450113.ger.abstr-s6-r5-t5.1-t6.1
associated_with
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-r6-t1.1-t5.1
treats
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-r7-t6.2-t4.1
occurs_in
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s6-r8-t1.1-t6.2
diagnoses
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-r9-t4.1-t1.1
performs
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-r11-t5.1-t1.1
associated_with
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-r12-t6.1-t5.1
result_of
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-r13-t6.1-t5.1
associated_with
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-r14-t6.2-t5.1
result_of
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-r15-t1.1-t6.1
diagnoses
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-r16-t1.1-t6.2
associated_with
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-r18-t5.1-t6.2
result_of
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-r19-t1.1-t6.1
associated_with
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-r20-t6.1-t1.1
associated_with
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-r21-t6.2-t5.1
associated_with
DerAnaesthesist.60450113.ger.abstr-s6-t6
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-r22-t1.1-t5.1
associated_with
DerAnaesthesist.60450113.ger.abstr-s6-t1
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-r23-t5.1-t4.1
occurs_in
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-t4
DerAnaesthesist.60450113.ger.abstr-s6-r24-t5.1-t6.2
associated_with
DerAnaesthesist.60450113.ger.abstr-s6-t5
DerAnaesthesist.60450113.ger.abstr-s6-t6