HNO.90471058.ger.abstr-passage-0
abstract
Im Rahmen der Tumortherapie mit Zytostatika , Ganz- und Teilkoerperbestrahlung treten immunsuppressive Effekte unterschiedlichen Ausmasses auf . Der Einfluss einer primaeren Radiochemotherapie in der Kopf-Hals-Region auf zellulaere und subzellulaere immunologische Parameter wurde bislang kaum untersucht und ist Gegenstand der vorliegenden Arbeit . Bei 50 Patienten mit fortgeschrittenen Plattenepithelkarzinomen des Oro- , Hypopharynx und Larynx wurde im Rahmen einer multizentrischen Phase-II-Studie eine akzelerierte " Concomitant-boost-Radiochemotherapie " mit Carboplatin durchgefuehrt . Im Verlauf der Therapie wurden die Blutkonzentrationen unterschiedlicher Parameter jeweils vor Beginn , zur Mitte , am Ende und 7 Wochen nach Therapie gemessen . Als Immunparameter wurden die Lymphozytensubpopulationen ( Gesamtlymphozyten T-Gesamtlymphozyten , T-Helferzellen , T-Suppressor- bzw. zytotoxische Lymphozyten , natuerliche Killerzellen , Monozyten , Interleukin-2-Rezeptor-positive T-Zellen , MHC-Klasse-II-positive B-Zellen , Monozyten und T-Zellen , CD4/CD8-Quotient) , untersucht . Zusaetzlich wurden die relevanten Interleukine ( Il Il-1, loeslicher Il-1-Rezeptorantagonist, Il-2, loeslicher Il-2-Rezeptor, Il-3, Il-4, Il-6, loeslicher Il-6-Rezeptor, Il-8, Interferon- , ) ( Granulozyten-Makrophagen-Kolonie-stimulierender Faktor , Tumornekrosefaktor- , loesliches interzellulaeres Adhaesionsmolekuel-1 untersucht . Die Lymphozytenfunktion wurde mittels Mitogenstimulation zu den oben beschriebenen Zeitpunkten getestet . Die Therapie verursachte einen hochsignifikanten reversiblen Konzentrationsabfall saemtlicher Lymphozytensubpopulationen im Blut . Gleichzeitig war die Lymphozytenfunktion in vitro nach Stimulation mit Mitogenen passager gestoert . Il-6 und loeslicher Il-1-Rezeptorantagonist zeigten einen reaktiven Konzentrationsanstieg , Il-8 einen Konzentrationsabfall unter Therapie . Die Ergebnisse geben Hinweise , dass die primaere Radiochemotherapie im Kopf-Hals-Bereich eine durch Messung der Immunparameter im peripheren Blut objektivierbare Immunsuppression verursacht . Anhand dieser Parameter ergibt sich ein Ansatz , die Effektivitaet supportiver Massnahmen zu pruefen und zu verbessern .
HNO.90471058.ger.abstr-s1-r1-t2.1-t3.1
uses
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s1-r2-t2.1-t1.1
associated_with
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s1-r3-t3.1-t1.1
diagnoses
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s1-r4-t1.1-t2.1
associated_with
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s2-r1-t2.1-t5.1
isa
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s2-r2-t4.1-t2.1
location_of
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s2-r3-t3.1-t2.1
location_of
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s3-r1-t3.1-t5.1
developmental_form_of
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s3-r2-t3.1-t7.1
produces
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s5-t7
HNO.90471058.ger.abstr-s3-r3-t7.1-t5.1
disrupts
HNO.90471058.ger.abstr-s5-t7
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s3-r4-t5.1-t3.1
surrounds
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s3-r5-t3.1-t6.1
developmental_form_of
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s3-r6-t6.1-t3.1
surrounds
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s3-r7-t5.1-t7.1
produces
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s5-t7
HNO.90471058.ger.abstr-s3-r8-t4.1-t3.1
produces
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s3-r9-t5.1-t4.1
location_of
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s3-r10-t6.1-t7.1
produces
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s5-t7
HNO.90471058.ger.abstr-s3-r11-t1.1-t2.1
uses
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s3-r12-t7.1-t4.1
affects
HNO.90471058.ger.abstr-s5-t7
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s3-r13-t4.1-t1.1
occurs_in
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s3-r14-t6.1-t4.1
location_of
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s3-r15-t2.1-t4.1
treats
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s3-r16-t7.1-t3.1
disrupts
HNO.90471058.ger.abstr-s5-t7
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s3-r17-t7.1-t6.1
disrupts
HNO.90471058.ger.abstr-s5-t7
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s3-r18-t3.1-t4.1
location_of
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s3-r19-t7.1-t4.1
diagnoses
HNO.90471058.ger.abstr-s5-t7
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s4-r1-t3.1-t2.2
produces
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s4-t2
HNO.90471058.ger.abstr-s4-r2-t1.2-t1.1
location_of
HNO.90471058.ger.abstr-s8-t1
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s4-r3-t1.1-t2.2
affects
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s4-t2
HNO.90471058.ger.abstr-s4-r4-t1.2-t2.2
result_of
HNO.90471058.ger.abstr-s8-t1
HNO.90471058.ger.abstr-s4-t2
HNO.90471058.ger.abstr-s4-r5-t1.1-t3.1
affects
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s4-r6-t1.2-t3.1
result_of
HNO.90471058.ger.abstr-s8-t1
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s4-r7-t2.2-t3.1
affects
HNO.90471058.ger.abstr-s4-t2
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s4-r8-t2.2-t1.2
derivative_of
HNO.90471058.ger.abstr-s4-t2
HNO.90471058.ger.abstr-s8-t1
HNO.90471058.ger.abstr-s4-r9-t1.2-t2.2
surrounds
HNO.90471058.ger.abstr-s8-t1
HNO.90471058.ger.abstr-s4-t2
HNO.90471058.ger.abstr-s4-r10-t4.2-t2.2
result_of
HNO.90471058.ger.abstr-s8-t4
HNO.90471058.ger.abstr-s4-t2
HNO.90471058.ger.abstr-s4-r11-t4.2-t3.1
result_of
HNO.90471058.ger.abstr-s8-t4
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s4-r12-t1.2-t2.2
location_of
HNO.90471058.ger.abstr-s8-t1
HNO.90471058.ger.abstr-s4-t2
HNO.90471058.ger.abstr-s4-r13-t1.2-t3.1
location_of
HNO.90471058.ger.abstr-s8-t1
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s6-r1-t6.1-t1.1
produces
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s6-r2-t1.1-t6.1
affects
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s6-r3-t5.1-t6.1
degree_of
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s6-r4-t2.1-t6.1
affects
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s6-r5-t3.1-t2.1
produces
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s6-r6-t3.1-t6.1
location_of
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s6-r7-t4.1-t2.1
produces
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s6-r8-t1.1-t6.1
indicates
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s6-r9-t1.1-t4.1
disrupts
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s6-r10-t1.1-t2.1
interacts_with
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s6-r11-t1.1-t5.1
affects
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s6-r12-t3.1-t5.1
location_of
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s6-r13-t5.1-t2.1
produces
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s6-r14-t2.1-t4.1
disrupts
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s6-r15-t2.1-t5.1
affects
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s6-r16-t4.1-t6.1
location_of
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s6-r17-t6.1-t5.1
degree_of
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s6-r18-t2.1-t6.1
diagnoses
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s6-r19-t3.1-t1.1
produces
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s6-r20-t2.1-t6.1
indicates
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s6-r21-t1.1-t5.1
indicates
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s6-r22-t6.1-t2.1
produces
HNO.90471058.ger.abstr-s11-t6
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s6-r23-t4.1-t1.1
produces
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s6-r24-t1.1-t3.1
disrupts
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s6-r25-t4.1-t5.1
location_of
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s6-r26-t2.1-t5.1
diagnoses
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s6-r27-t2.1-t5.1
indicates
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s6-r28-t5.1-t1.1
produces
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s6-r29-t2.1-t3.1
disrupts
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s6-r30-t2.1-t1.1
interacts_with
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s8-r1-t4.1-t4.2
surrounds
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s8-t4
HNO.90471058.ger.abstr-s8-r2-t4.1-t1.1
location_of
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s11-t1
HNO.90471058.ger.abstr-s8-r3-t4.2-t4.1
derivative_of
HNO.90471058.ger.abstr-s8-t4
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s11-r1-t3.1-t2.1
location_of
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-r3-t3.1-t5.2
location_of
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s11-r4-t4.1-t2.1
location_of
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-r5-t4.1-t5.2
location_of
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s11-r6-t3.1-t5.1
location_of
HNO.90471058.ger.abstr-s11-t3
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s11-r7-t5.1-t2.1
location_of
HNO.90471058.ger.abstr-s11-t5
HNO.90471058.ger.abstr-s11-t2
HNO.90471058.ger.abstr-s11-r9-t4.1-t5.1
location_of
HNO.90471058.ger.abstr-s11-t4
HNO.90471058.ger.abstr-s11-t5