DerAnaesthesist.60451171.ger.abstr-passage-0
abstract
Die Zytokine Interleukin-2 IL-2) und Interferon- ( ( IFN ) werden zur Immuntherapie metastasierender Malignome eingesetzt . In der vorliegenden Studie wurde bei 11 Patienten mit Nierenzellkarzinom die Haemodynamik waehrend einer fuenftaegigen , hochdosierten , kontinuierlichen IL-2 Infusion in Kombination mit der i.m. -Applikation von IFN mit einem Pulmonalarterienkatheter invasiv ueberwacht . Die Patienten entwickelten wenige Stunden nach Beginn der kontinuierlichen IL-2 Infusion ein Syndrom aus Fieber , Tachykardie , Tachypnoe und im weiteren Verlauf Leukozytose ( SIRS ) . Die Haemodynamik aehnelte den hyperdynamen Kreislaufverhaeltnissen bei SIRS und Sepsis . Hinweise auf eine Mikrozirkulationsstoerung ergaben sich aus einem Anstieg der Plasma-Laktatkonzentrationen , muliplen Organfunktionsstoerungen und einer erheblichen interstitiellen Fluessigkeitsretention aufgrund eines vascular leak " -Syndroms . " Hieraus und aus der von anderen Autoren beschriebenen Aktivierung von Sepsis-typischen Mediatoren unter IL-2-Applikation schliessen wir auf eine weitgehende Parallelitaet in der Pathogenese von hochdosierter IL-2-/IFN Therapie und SIRS bzw. Sepsis . Die IL-2-/IFN Therapie bietet sich daher als klinisches Modell der Sepsis an .
DerAnaesthesist.60451171.ger.abstr-s1-r1-t5.1-t3.1
uses
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s1-r2-t4.1-t3.1
uses
DerAnaesthesist.60451171.ger.abstr-s3-t4
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s1-r3-t1.1-t2.1
interacts_with
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s1-r4-t3.1-t2.1
interacts_with
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s1-r5-t2.1-t3.1
interacts_with
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s1-r6-t3.1-t1.1
interacts_with
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s1-r7-t1.1-t3.1
interacts_with
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s1-r8-t2.1-t1.1
interacts_with
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s2-r1-t2.1-t3.1
produces
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s2-r2-t3.1-t2.1
affects
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s2-r3-t4.1-t3.1
produces
DerAnaesthesist.60451171.ger.abstr-s3-t4
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s2-r4-t3.1-t4.1
disrupts
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s3-t4
DerAnaesthesist.60451171.ger.abstr-s2-r5-t4.1-t2.1
location_of
DerAnaesthesist.60451171.ger.abstr-s3-t4
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s3-r1-t5.1-t3.1
degree_of
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s3-r2-t5.1-t6.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s3-t6
DerAnaesthesist.60451171.ger.abstr-s3-r3-t5.1-t4.1
co-occurs_with
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s3-t4
DerAnaesthesist.60451171.ger.abstr-s3-r4-t6.1-t3.1
degree_of
DerAnaesthesist.60451171.ger.abstr-s3-t6
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s3-r5-t5.1-t4.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s3-t4
DerAnaesthesist.60451171.ger.abstr-s3-r6-t3.1-t5.1
degree_of
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s3-r7-t5.1-t3.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s3-r8-t2.1-t3.1
affects
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s3-r9-t3.1-t1.1
occurs_in
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s3-r10-t2.1-t6.1
affects
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s3-t6
DerAnaesthesist.60451171.ger.abstr-s3-r11-t3.1-t2.1
produces
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s3-r12-t2.1-t3.1
indicates
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s3-r13-t3.1-t5.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s3-r14-t6.1-t5.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s3-t6
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s3-r15-t3.1-t4.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s3-t4
DerAnaesthesist.60451171.ger.abstr-s3-r16-t6.1-t4.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s3-t6
DerAnaesthesist.60451171.ger.abstr-s3-t4
DerAnaesthesist.60451171.ger.abstr-s3-r17-t5.1-t1.1
occurs_in
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s3-r18-t5.1-t2.1
produces
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s3-r19-t2.1-t5.1
affects
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s3-r20-t2.1-t6.1
indicates
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s3-t6
DerAnaesthesist.60451171.ger.abstr-s3-r21-t4.1-t5.1
co-occurs_with
DerAnaesthesist.60451171.ger.abstr-s3-t4
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s3-r22-t4.1-t6.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s3-t4
DerAnaesthesist.60451171.ger.abstr-s3-t6
DerAnaesthesist.60451171.ger.abstr-s3-r23-t6.1-t2.1
produces
DerAnaesthesist.60451171.ger.abstr-s3-t6
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s3-r24-t4.1-t5.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s3-t4
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s3-r25-t6.1-t1.1
occurs_in
DerAnaesthesist.60451171.ger.abstr-s3-t6
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s3-r26-t4.1-t3.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s3-t4
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s3-r27-t2.1-t5.1
indicates
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s3-t5
DerAnaesthesist.60451171.ger.abstr-s3-r28-t3.1-t6.1
degree_of
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s3-t6
DerAnaesthesist.60451171.ger.abstr-s4-r1-t1.1-t2.2
result_of
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s4-r2-t2.1-t1.1
evaluation_of
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s4-r4-t1.1-t2.1
result_of
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s4-r6-t2.1-t1.1
result_of
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s4-r7-t2.2-t1.1
result_of
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s6-r1-t2.1-t3.2
associated_with
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s6-r3-t2.1-t1.2
associated_with
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s6-r4-t2.1-t1.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s6-r5-t2.2-t3.2
associated_with
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s6-r6-t2.2-t1.2
associated_with
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s6-r7-t2.2-t1.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s6-r8-t1.1-t3.2
associated_with
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s6-t3
DerAnaesthesist.60451171.ger.abstr-s6-r9-t1.1-t2.2
associated_with
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s7-r1-t1.2-t2.2
associated_with
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s7-r3-t2.2-t1.2
associated_with
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s7-r4-t2.2-t1.1
associated_with
DerAnaesthesist.60451171.ger.abstr-s7-t2
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s7-r5-t1.1-t2.2
associated_with
DerAnaesthesist.60451171.ger.abstr-s7-t1
DerAnaesthesist.60451171.ger.abstr-s7-t2