HNO.00480367.ger.abstr-passage-0
abstract
Es wird davon ausgegangen , dass es waehrend der Entstehung von Kopf-Hals-Karzinomen zu einer Akkumulation von genetischen Veraenderungen kommt . In der vorliegenden Studie wurden Tumorbiopsien von 11 Patienten mit Kopf-Hals-Plattenepithelkarzinomen und Leukoplakiebiopsien von 16 Patienten ohne Hinweis fuer ein Karzinom mit Hilfe der Fluoreszenz-in-situ-Hybridisierung ( FISH ) auf numerische Aberrationen der Chromosomen 1 , 7 , 9 , 10 und 17 untersucht . Im durchgefuehrten Cochran-Armitage-Trend-Test , in dem die Gruppen lediglich hyperplastischen Leukoplakien ( Gruppe 1 , n = 8 ) , der dysplastischen Leukoplakien ( Gruppe 2 , n = 8 ) und der Plattenepithelkarzinome ( Gruppe 3 , n = 11 ) bezueglich des Vorhandenseins von Aberrationen miteinander verglichen wurden , zeigte sich von Gruppe 1 zu Gruppe 3 ein hochsignifikanter Anstieg der Raten an Aberrationen ( p 0,001 ) . Die gewonnen Daten eroeffnen die Moeglichkeit , mit Hilfe der FISH das maligne Entartungspotential von Leukoplakien zuverlaessiger als durch die uebliche histologische Beurteilung einzuschaetzen .
HNO.00480367.ger.abstr-s1-r1-t2.1-t3.1
location_of
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s3-t3
HNO.00480367.ger.abstr-s1-r2-t1.1-t3.1
location_of
HNO.00480367.ger.abstr-s4-t1
HNO.00480367.ger.abstr-s3-t3
HNO.00480367.ger.abstr-s2-r1-t2.1-t7.1
associated_with
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s2-t7
HNO.00480367.ger.abstr-s2-r2-t7.1-t2.1
associated_with
HNO.00480367.ger.abstr-s2-t7
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s2-r3-t6.1-t9.1
treats
HNO.00480367.ger.abstr-s2-t6
HNO.00480367.ger.abstr-s2-t9
HNO.00480367.ger.abstr-s2-r4-t4.1-t9.1
location_of
HNO.00480367.ger.abstr-s2-t4
HNO.00480367.ger.abstr-s2-t9
HNO.00480367.ger.abstr-s2-r5-t7.1-t8.1
occurs_in
HNO.00480367.ger.abstr-s2-t7
HNO.00480367.ger.abstr-s2-t8
HNO.00480367.ger.abstr-s2-r6-t1.1-t8.1
occurs_in
HNO.00480367.ger.abstr-s4-t1
HNO.00480367.ger.abstr-s2-t8
HNO.00480367.ger.abstr-s2-r7-t2.1-t3.1
affects
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s3-t3
HNO.00480367.ger.abstr-s2-r8-t2.1-t1.1
associated_with
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s4-t1
HNO.00480367.ger.abstr-s2-r9-t5.1-t9.1
location_of
HNO.00480367.ger.abstr-s2-t5
HNO.00480367.ger.abstr-s2-t9
HNO.00480367.ger.abstr-s2-r10-t10.1-t9.1
location_of
HNO.00480367.ger.abstr-s2-t10
HNO.00480367.ger.abstr-s2-t9
HNO.00480367.ger.abstr-s2-r11-t4.1-t2.1
location_of
HNO.00480367.ger.abstr-s2-t4
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s2-r12-t7.1-t3.1
occurs_in
HNO.00480367.ger.abstr-s2-t7
HNO.00480367.ger.abstr-s3-t3
HNO.00480367.ger.abstr-s2-r13-t4.1-t7.1
location_of
HNO.00480367.ger.abstr-s2-t4
HNO.00480367.ger.abstr-s2-t7
HNO.00480367.ger.abstr-s2-r14-t8.1-t2.1
performs
HNO.00480367.ger.abstr-s2-t8
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s2-r15-t1.1-t3.1
occurs_in
HNO.00480367.ger.abstr-s4-t1
HNO.00480367.ger.abstr-s3-t3
HNO.00480367.ger.abstr-s2-r16-t9.1-t8.1
occurs_in
HNO.00480367.ger.abstr-s2-t9
HNO.00480367.ger.abstr-s2-t8
HNO.00480367.ger.abstr-s2-r17-t4.1-t1.1
location_of
HNO.00480367.ger.abstr-s2-t4
HNO.00480367.ger.abstr-s4-t1
HNO.00480367.ger.abstr-s2-r18-t5.1-t2.1
location_of
HNO.00480367.ger.abstr-s2-t5
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s2-r19-t9.1-t2.1
associated_with
HNO.00480367.ger.abstr-s2-t9
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s2-r20-t5.1-t7.1
location_of
HNO.00480367.ger.abstr-s2-t5
HNO.00480367.ger.abstr-s2-t7
HNO.00480367.ger.abstr-s2-r21-t2.1-t8.1
affects
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s2-t8
HNO.00480367.ger.abstr-s2-r22-t10.1-t2.1
location_of
HNO.00480367.ger.abstr-s2-t10
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s2-r23-t9.1-t3.1
occurs_in
HNO.00480367.ger.abstr-s2-t9
HNO.00480367.ger.abstr-s3-t3
HNO.00480367.ger.abstr-s2-r24-t10.1-t7.1
location_of
HNO.00480367.ger.abstr-s2-t10
HNO.00480367.ger.abstr-s2-t7
HNO.00480367.ger.abstr-s2-r25-t6.1-t7.1
treats
HNO.00480367.ger.abstr-s2-t6
HNO.00480367.ger.abstr-s2-t7
HNO.00480367.ger.abstr-s2-r26-t8.1-t6.1
uses
HNO.00480367.ger.abstr-s2-t8
HNO.00480367.ger.abstr-s2-t6
HNO.00480367.ger.abstr-s2-r27-t3.1-t6.1
uses
HNO.00480367.ger.abstr-s3-t3
HNO.00480367.ger.abstr-s2-t6
HNO.00480367.ger.abstr-s2-r28-t2.1-t6.1
uses
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s2-t6
HNO.00480367.ger.abstr-s2-r29-t6.1-t1.1
treats
HNO.00480367.ger.abstr-s2-t6
HNO.00480367.ger.abstr-s4-t1
HNO.00480367.ger.abstr-s2-r30-t5.1-t1.1
location_of
HNO.00480367.ger.abstr-s2-t5
HNO.00480367.ger.abstr-s4-t1
HNO.00480367.ger.abstr-s2-r31-t2.1-t9.1
associated_with
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s2-t9
HNO.00480367.ger.abstr-s2-r32-t3.1-t2.1
performs
HNO.00480367.ger.abstr-s3-t3
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s2-r33-t1.1-t2.1
associated_with
HNO.00480367.ger.abstr-s4-t1
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s2-r34-t10.1-t1.1
location_of
HNO.00480367.ger.abstr-s2-t10
HNO.00480367.ger.abstr-s4-t1
HNO.00480367.ger.abstr-s3-r1-t3.1-t2.1
produces
HNO.00480367.ger.abstr-s3-t3
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s3-r2-t2.1-t3.1
location_of
HNO.00480367.ger.abstr-s3-t2
HNO.00480367.ger.abstr-s3-t3
HNO.00480367.ger.abstr-s3-r3-t1.1-t3.1
treats
HNO.00480367.ger.abstr-s4-t1
HNO.00480367.ger.abstr-s3-t3