• Diabetes duration >12 years
Currently taking more than three glucose lowering therapies
Weight-loss of >5kg in the preceding 6 months
Stage 4 or 5 chronic kidney disease (eGFR< 30ml/min/1.73m2),
Current therapy with Insulin, thiazolidinediones, steroids or atypical antipsychotic medication
Untreated thyroid disease
Known macrovascular disease including coronary artery disease, stroke/TIA or peripheral vascular disease
Presence of arrhythmia (including atrial fibrillation, atrial flutter, or 2nd or 3rd degree atrioventricular block)
Known heart failure
Other clinically relevant heart disease
Inability to exercise or undertake a MRP
Absolute contraindication to CMR
Cardiovascular symptoms (angina, limiting dyspnoea during normal physical activity)
Inflammatory condition e.g. Connective tissue disorder, Rheumatoid arthritis

NCT02590822_exc_T1
Condition
Diabetes
NCT02590822_exc_T2
Temporal
>12 years
NCT02590822_exc_T3
Multiplier
more than three
NCT02590822_exc_T4
Procedure
glucose lowering therapies
NCT02590822_exc_T5
Observation
Weight-loss
NCT02590822_exc_T6
Value
>5kg
NCT02590822_exc_T7
Temporal
preceding 6 months
NCT02590822_exc_T8
Condition
chronic kidney disease
NCT02590822_exc_T9
Qualifier
Stage 4 or 5
NCT02590822_exc_T10
Measurement
eGFR
NCT02590822_exc_T11
Value
< 30ml/min/1.73m2
NCT02590822_exc_T12
Drug
Insulin
NCT02590822_exc_T13
Drug
thiazolidinediones
NCT02590822_exc_T14
Drug
steroids
NCT02590822_exc_T15
Drug
atypical antipsychotic medication
NCT02590822_exc_T16
Condition
thyroid disease
NCT02590822_exc_T17
Qualifier
Untreated
NCT02590822_exc_T18
Condition
macrovascular disease
NCT02590822_exc_T19
Condition
coronary artery disease
NCT02590822_exc_T20
Condition
stroke
NCT02590822_exc_T21
Condition
TIA
NCT02590822_exc_T22
Condition
peripheral vascular disease
NCT02590822_exc_T23
Scope
coronary artery disease, stroke/TIA or peripheral vascular disease
NCT02590822_exc_T24
Condition
arrhythmia
NCT02590822_exc_T25
Condition
atrial fibrillation
NCT02590822_exc_T26
Condition
atrial flutter
NCT02590822_exc_T27
Condition
3rd degree atrioventricular block
NCT02590822_exc_T28
Condition
3rd atrioventricular block)
Known
NCT02590822_exc_T29
Scope
atrial fibrillation, atrial flutter, or 2nd or 3rd degree atrioventricular block
NCT02590822_exc_T30
Condition
heart failure
NCT02590822_exc_T31
Condition
heart disease
NCT02590822_exc_T32
Observation
exercise
NCT02590822_exc_T33
Procedure
MRP
NCT02590822_exc_T34
Negation
Inability
NCT02590822_exc_T35
Scope
exercise or undertake a MRP
NCT02590822_exc_T36
Condition
contraindication
NCT02590822_exc_T37
Procedure
CMR
NCT02590822_exc_T38
Condition
Cardiovascular symptoms
NCT02590822_exc_T39
Condition
ting d
NCT02590822_exc_T40
Condition
dyspnoea
NCT02590822_exc_T41
Scope
angina, limiting dyspnoea
NCT02590822_exc_T42
Condition
Inflammatory
NCT02590822_exc_T43
Condition
Connective tissue disorder,
NCT02590822_exc_T44
Condition
Rheumatoid arthritis
NCT02590822_exc_T45
Scope
Connective tissue disorder, Rheumatoid arthritis