Moderate to severe COPD (post-bronchodilator forced expiratory volume in 1 s (FEV1) 30-79%predicted);
Resting functional residual capacity (FRC) >120% predicted;
Clinically stable and on stable triple therapy with an ICS/LABA and tiotropium;
Symptomatic: Baseline Dyspnea Index =8 and answer "in the morning" when asked about what time of day their COPD symptoms are worst.

NCT02429765_inc_T1
Qualifier
Moderate to severe
NCT02429765_inc_T2
Condition
COPD
NCT02429765_inc_T3
Qualifier
post-bronchodilator
NCT02429765_inc_T4
Measurement
forced expiratory volume in 1 s (FEV1)
NCT02429765_inc_T5
Value
30-79%predicted
NCT02429765_inc_T6
Measurement
Resting functional residual capacity (FRC)
NCT02429765_inc_T7
Value
>120% predicted
NCT02429765_inc_T8
Procedure
stable triple therapy
NCT02429765_inc_T9
Condition
Clinically stable
NCT02429765_inc_T10
Drug
ICS/LABA
NCT02429765_inc_T11
Drug
tiotropium
NCT02429765_inc_T12
Scope
ICS/LABA and tiotropium
NCT02429765_inc_T13
Measurement
Baseline Dyspnea Index
NCT02429765_inc_T14
Value
=8
NCT02429765_inc_T15
Observation
what time of day their COPD symptoms are worst
NCT02429765_inc_T16
Value
in the morning