Preoperative history of schizophrenia, epilepsy, parkinsonism or myasthenia gravis;
Preoperative radio- or chemotherapy;
Inability to communicate in the preoperative period because of coma, profound dementia or language barrier;
Preoperative obstructive sleep apnea (previously diagnosed as obstructive sleep apnea, or a STOP-Bang score >= 3);
Brain trauma or neurosurgery;
Preoperative left ventricular ejection fraction < 30%, sick sinus syndrome, severe sinus bradycardia (< 50 beats per minute), or second-degree or above atrioventricular block without pacemaker;
Severe hepatic dysfunction (Child-Pugh class C) or severe renal dysfunction (requirement of renal replacement therapy before surgery);
ASA classification >= IV.

NCT03012984_exc_T1
Condition
schizophrenia
NCT03012984_exc_T2
Condition
epilepsy
NCT03012984_exc_T3
Condition
parkinsonism
NCT03012984_exc_T4
Condition
myasthenia gravis
NCT03012984_exc_T5
Observation
history
NCT03012984_exc_T6
Temporal
Preoperative
NCT03012984_exc_T7
Scope
schizophrenia, epilepsy, parkinsonism or myasthenia gravis
NCT03012984_exc_T8
Procedure
chemotherapy
NCT03012984_exc_T9
Procedure
herapy; adio-
NCT03012984_exc_T10
Temporal
Preoperative
NCT03012984_exc_T11
Scope
radio- or chemotherapy
NCT03012984_exc_T12
Condition
coma
NCT03012984_exc_T13
Condition
dementia
NCT03012984_exc_T14
Qualifier
profound
NCT03012984_exc_T15
Observation
language barrier
NCT03012984_exc_T16
Temporal
preoperative period
NCT03012984_exc_T17
Condition
Inability to communicate
NCT03012984_exc_T18
Scope
coma, profound dementia or language barrier
NCT03012984_exc_T19
Condition
obstructive sleep apnea
NCT03012984_exc_T20
Temporal
Preoperative
NCT03012984_exc_T21
Condition
obstructive sleep apnea
NCT03012984_exc_T22
Measurement
STOP-Bang score
NCT03012984_exc_T23
Value
>= 3
NCT03012984_exc_T24
Scope
obstructive sleep apnea, or a STOP-Bang score >= 3
NCT03012984_exc_T25
Scope
Preoperative obstructive sleep apnea
NCT03012984_exc_T26
Condition
Brain trauma
NCT03012984_exc_T27
Procedure
neurosurgery
NCT03012984_exc_T28
Measurement
left ventricular ejection fraction
NCT03012984_exc_T29
Value
< 30%
NCT03012984_exc_T30
Temporal
Preoperative
NCT03012984_exc_T31
Condition
sick sinus syndrome
NCT03012984_exc_T32
Qualifier
severe
NCT03012984_exc_T33
Condition
sinus bradycardia
NCT03012984_exc_T34
Value
< 50 beats per minute
NCT03012984_exc_T35
Condition
atrioventricular block
NCT03012984_exc_T36
Negation
without
NCT03012984_exc_T37
Device
pacemaker
NCT03012984_exc_T38
Qualifier
second-degree or above
NCT03012984_exc_T39
Qualifier
Severe
NCT03012984_exc_T40
Condition
hepatic dysfunction
NCT03012984_exc_T41
Measurement
Child-Pugh
NCT03012984_exc_T42
Value
class C
NCT03012984_exc_T43
Scope
Severe hepatic dysfunction
NCT03012984_exc_T44
Scope
Child-Pugh class C
NCT03012984_exc_T45
Qualifier
severe
NCT03012984_exc_T46
Condition
renal dysfunction
NCT03012984_exc_T47
Procedure
renal replacement therapy
NCT03012984_exc_T48
Temporal
before surgery
NCT03012984_exc_T49
Reference_point
surgery
NCT03012984_exc_T50
Procedure
surgery
NCT03012984_exc_T51
Scope
severe renal dysfunction
NCT03012984_exc_T52
Scope
renal replacement therapy before surgery
NCT03012984_exc_T53
Measurement
ASA classification
NCT03012984_exc_T54
Value
>= IV