Patients of familial cases of POF : 
Female subjects between 16 and 40 years or women older than 40 years with a cessation of ovarian function before the age of 40 years with increased levels of FSH 
Primary or secondary amenorrhea for more than three months with LH and FSH> 30mUI/ml 
No cases of fragile X syndrome in the family or blepharophimosis syndrome 
At least two cases in the family 
Origin Caucasian 
Patient signing the consent form for at least the blood sample 
Patient with Social Security 
Population Index related topics : 
The presence of cycles until the age of 40 years with proven fertility, at least one child 
Amenorrhea and FSH> 30mUI/ml according to the criteria of the index subject 
Men of the family of index case 
Population control : 
Women of Caucasian origin 
Women who had regular cycles until at least age 40 and at least one child 
Lack of land autoimmune (no history of thyroid disease or diabetes type 1) 
Woman signing the consent form for at least the blood sample 

NCT01177891_inc_T2
Person
Female
NCT01177891_inc_T3
Value
between 16 and 40 years
NCT01177891_inc_T4
Value
older than 40 years
NCT01177891_inc_T5
Person
years
NCT01177891_inc_T6
Person
women
NCT01177891_inc_T7
Reference_point
older
NCT01177891_inc_T8
Condition
cessation of ovarian function
NCT01177891_inc_T9
Value
before the age of 40 years
NCT01177891_inc_T10
Person
age
NCT01177891_inc_T11
Value
increased
NCT01177891_inc_T12
Measurement
levels of FSH
NCT01177891_inc_T13
Condition
amenorrhea
NCT01177891_inc_T14
Qualifier
secondary
NCT01177891_inc_T15
Qualifier
Primary
NCT01177891_inc_T16
Scope
Primary or secondary
NCT01177891_inc_T17
Temporal
for more than three months
NCT01177891_inc_T18
Measurement
LH
NCT01177891_inc_T19
Measurement
FSH
NCT01177891_inc_T20
Value
> 30mUI/ml
NCT01177891_inc_T21
Scope
LH and FSH
NCT01177891_inc_T22
Condition
fragile X syndrome
NCT01177891_inc_T23
Observation
in the family
NCT01177891_inc_T24
Condition
blepharophimosis syndrome
NCT01177891_inc_T25
Negation
No
NCT01177891_inc_T26
Scope
fragile X syndrome in the family or blepharophimosis syndrome
NCT01177891_inc_T27
Multiplier
At least two
NCT01177891_inc_T30
Condition
Caucasian
NCT01177891_inc_T34
Condition
presence of cycles
NCT01177891_inc_T35
Value
until the age of 40 years
NCT01177891_inc_T36
Person
age
NCT01177891_inc_T38
Condition
Amenorrhea
NCT01177891_inc_T39
Measurement
FSH
NCT01177891_inc_T40
Value
> 30mUI/ml
NCT01177891_inc_T42
Condition
Caucasian origin
NCT01177891_inc_T43
Person
Women
NCT01177891_inc_T44
Person
Women
NCT01177891_inc_T45
Condition
regular cycles
NCT01177891_inc_T48
Value
until at least age 40
NCT01177891_inc_T49
Person
age
NCT01177891_inc_T50
Condition
who had regular cycles until at least age 40
NCT01177891_inc_T51
Condition
autoimmune
NCT01177891_inc_T52
Condition
thyroid disease
NCT01177891_inc_T53
Condition
diabetes type 1
NCT01177891_inc_T54
Negation
no
NCT01177891_inc_T55
Observation
history
NCT01177891_inc_T56
Scope
thyroid disease or diabetes type 1