Participants must present a diagnosis of osteoporosis based on DXA measurement of the bone mineral density at the femur neck and/or total hip and/or lumbar spine (T value 2.5 SD or more below the young female adult mean) within the past 24 months.
Not in treatment with anti-resorptive agents (like bisphosphonates and denosumab) for more than 4 consecutive years, in order to reduce the risk of medication-related osteonecrosis of the jaws (Lo et al., 2010).
= 50 years old.
In self-reported menopause, defined as the permanent cessation of ovulation, for at least one year (Soules et al., 2001).
Edentulous area involving a maximum of two teeth (wisdom teeth and second molars are excluded) and presenting at least one neighbouring tooth (e.g. gap in the area of a second premolar and first molar, with first premolar in place).
Residual alveolar width = 4 mm (Milinkovic and Cordaro, 2014), residual alveolar height >8 mm, enough inter-arch space for a crown (at least 5 mm) and a minimum distance of 7 mm from the adjacent teeth (Shah and Lum, 2008). The width and height will be confirmed after x-ray examination in Visit 2.
Possibility to restore a functional occlusion with a minimum of four occlusal units (i.e. pairs of occluding posterior teeth).
Willingness to replace the missing tooth/teeth with dental implants
Registration with a GDP

NCT02884401_inc_T1
Condition
osteoporosis
NCT02884401_inc_T2
Procedure
DXA
NCT02884401_inc_T3
Measurement
bone mineral density
NCT02884401_inc_T4
Qualifier
femur neck
NCT02884401_inc_T5
Qualifier
total hip
NCT02884401_inc_T6
Qualifier
lumbar spine
NCT02884401_inc_T7
Scope
femur neck and/or total hip and/or lumbar spine
NCT02884401_inc_T8
Temporal
past 24 months
NCT02884401_inc_T9
Measurement
T value
NCT02884401_inc_T10
Value
2.5 SD or more below the young female adult mean
NCT02884401_inc_T11
Negation
Not
NCT02884401_inc_T12
Drug
anti-resorptive agents
NCT02884401_inc_T13
Drug
bisphosphonates
NCT02884401_inc_T14
Drug
denosumab
NCT02884401_inc_T15
Scope
bisphosphonates and denosumab
NCT02884401_inc_T16
Temporal
more than 4 consecutive years,
NCT02884401_inc_T17
Person
old
NCT02884401_inc_T18
Value
= 50 years
NCT02884401_inc_T19
Condition
menopause
NCT02884401_inc_T20
Condition
cessation of ovulation
NCT02884401_inc_T21
Qualifier
permanent
NCT02884401_inc_T22
Temporal
at least one year
NCT02884401_inc_T24
Measurement
Residual alveolar width
NCT02884401_inc_T25
Value
= 4 mm
NCT02884401_inc_T26
Measurement
residual alveolar height
NCT02884401_inc_T27
Value
>8 mm