History of severe related adverse event(s) from previous participation in VA-001 or VA-006 trials or to any smallpox vaccination.
Eczema, history of eczema, exfoliative skin conditions, wounds, burns, or other skin conditions at the investigator's discretion.
A history of immunodeficiency.
Currently or has recently received radiotherapy or chemotherapy, adrenocorticotropic hormone (ACTH), corticosteroids, or immunosuppressive drugs.
Eye disease treated with topical steroids.
Known or suspected disorders of immunoglobulin synthesis.
Leukemia, lymphomas of any type, melanoma, or other malignant neoplasms affecting the bone marrow or lymphatic systems.
Has been diagnosed with cancer and who will be undergoing chemotherapy or radiation therapy during the vaccination healing time.
Is a transplant recipient (except for corneal transplant).
Is pregnant, planning pregnancy or breast feeding (female subjects of childbearing potential must have negative pregnancy test prior to vaccination).
Household or other close/intimate contact(s) under the age of 12 months.
History of allergies to phenol, any of the antibiotics listed in the vaccine content, or any other component of ACAM2000 or its diluents.
Subjects with kidney disease (except kidney stones).
Subjects with abnormal EKG at screening (if applicable). To mitigate the risk of enrolling at risk subjects and potentially jeopardizing subject safety an EKG will be performed prior to vaccination with ACAM2000 smallpox vaccine in all potential subjects =50 years old and for all potential subjects <50 with two cardiac risk factors as listed immediately below including; severely or morbidly obese or higher obesity classification (BMI =36); high blood pressure; high blood cholesterol; diabetes or high blood sugar; a first degree relative who had a heart condition before the age of 50; and current tobacco smokers.
Severely or morbidly obese or higher obesity classification (BMI =36)
High blood pressure diagnosed by a doctor
High blood cholesterol diagnosed by a doctor
Diabetes or high blood sugar diagnosed by a doctor
A first degree relative (for example, mother, father, brother, sister) who had a heart condition before the age of 50
Currently smokes tobacco (cigarettes)
Arrhythmia
Syncope related to cardiac disease
Previous myocardial infarction
Angina
Coronary artery disease
Congestive heart failure
Cardiomyopathy
Stroke or transient ischemic attack
Myocarditis
Pericarditis
Chest pain or shortness of breath with activity (such as climbing stairs), peripheral edema, heart palpitations, dry cough, irregular heartbeat, excessive fatigue, unexplained syncope
Other heart conditions being treated by a physician

NCT02443623_exc_T1
Condition
adverse event
NCT02443623_exc_T2
Procedure
smallpox vaccination
NCT02443623_exc_T4
Condition
Eczema
NCT02443623_exc_T5
Observation
history of eczema
NCT02443623_exc_T6
Condition
exfoliative skin conditions
NCT02443623_exc_T7
Condition
wounds
NCT02443623_exc_T8
Condition
burns
NCT02443623_exc_T9
Condition
other skin conditions
NCT02443623_exc_T11
Condition
history of immunodeficiency
NCT02443623_exc_T12
Procedure
radiotherapy
NCT02443623_exc_T13
Procedure
chemotherapy
NCT02443623_exc_T14
Temporal
recently
NCT02443623_exc_T15
Drug
adrenocorticotropic hormone
NCT02443623_exc_T16
Drug
ACTH
NCT02443623_exc_T17
Drug
corticosteroids
NCT02443623_exc_T18
Procedure
immunosuppressive drugs
NCT02443623_exc_T19
Scope
radiotherapy or chemotherapy, adrenocorticotropic hormone (ACTH), corticosteroids, or immunosuppressive drugs
NCT02443623_exc_T20
Condition
Eye disease
NCT02443623_exc_T21
Procedure
topical steroids
NCT02443623_exc_T22
Condition
disorders of immunoglobulin synthesis
NCT02443623_exc_T23
Qualifier
Known
NCT02443623_exc_T24
Qualifier
suspected
NCT02443623_exc_T25
Scope
Known or suspected
NCT02443623_exc_T26
Condition
Leukemia
NCT02443623_exc_T27
Condition
lymphomas
NCT02443623_exc_T28
Condition
melanoma
NCT02443623_exc_T29
Condition
malignant neoplasms
NCT02443623_exc_T30
Qualifier
affecting the bone marrow
NCT02443623_exc_T31
Condition
bone marrow
NCT02443623_exc_T32
Condition
lymphatic systems
NCT02443623_exc_T33
Qualifier
ing the b tic systems.
Has
NCT02443623_exc_T34
Scope
affecting the bone marrow or lymphatic systems
NCT02443623_exc_T35
Condition
diagnosed with cancer
NCT02443623_exc_T36
Procedure
chemotherapy
NCT02443623_exc_T37
Procedure
radiation therapy
NCT02443623_exc_T38
Temporal
during the vaccination healing time
NCT02443623_exc_T39
Reference_point
vaccination healing time
NCT02443623_exc_T40
Scope
chemotherapy or radiation therapy
NCT02443623_exc_T41
Person
transplant recipient
NCT02443623_exc_T42
Negation
except
NCT02443623_exc_T43
Condition
corneal transplant
NCT02443623_exc_T44
Condition
pregnant
NCT02443623_exc_T45
Observation
planning pregnancy
NCT02443623_exc_T46
Observation
breast feeding
NCT02443623_exc_T48
Person
close/intimate contact(s)
NCT02443623_exc_T49
Person
age
NCT02443623_exc_T50
Value
age o 
Histor
NCT02443623_exc_T51
Person
Household
NCT02443623_exc_T52
Condition
allergies
NCT02443623_exc_T53
Drug
phenol
NCT02443623_exc_T54
Procedure
antibiotics
NCT02443623_exc_T55
Qualifier
listed in the vaccine content
NCT02443623_exc_T56
Procedure
vaccine
NCT02443623_exc_T57
Drug
ACAM2000
NCT02443623_exc_T58
Drug
 its di ubjects
NCT02443623_exc_T59
Scope
phenol, any of the antibiotics listed in the vaccine content, or any other component of ACAM2000 or its diluents.
NCT02443623_exc_T60
Condition
kidney disease
NCT02443623_exc_T61
Negation
except
NCT02443623_exc_T62
Condition
kidney stones
NCT02443623_exc_T63
Procedure
EKG
NCT02443623_exc_T64
Value
abnormal
NCT02443623_exc_T65
Temporal
at screening
NCT02443623_exc_T66
Reference_point
screening
NCT02443623_exc_T68
Condition
obese
NCT02443623_exc_T69
Qualifier
morbidly
NCT02443623_exc_T70
Qualifier
Severely
NCT02443623_exc_T71
Observation
higher obesity classification
NCT02443623_exc_T72
Measurement
BMI
NCT02443623_exc_T73
Value
=36
NCT02443623_exc_T74
Condition
High blood pressure
NCT02443623_exc_T75
Condition
High blood cholesterol
NCT02443623_exc_T76
Condition
Diabetes
NCT02443623_exc_T77
Condition
high blood sugar
NCT02443623_exc_T78
Person
A first degree relative
NCT02443623_exc_T79
Condition
heart condition
NCT02443623_exc_T80
Temporal
before the age of 50
NCT02443623_exc_T81
Reference_point
age of 50
NCT02443623_exc_T82
Person
age
NCT02443623_exc_T83
Value
50
NCT02443623_exc_T84
Person
mother
NCT02443623_exc_T85
Person
father
NCT02443623_exc_T86
Person
brother
NCT02443623_exc_T87
Person
sister
NCT02443623_exc_T88
Scope
mother, father, brother, sister
NCT02443623_exc_T89
Observation
smokes tobacco
NCT02443623_exc_T90
Observation
arette mia
Syncop
NCT02443623_exc_T91
Condition
Arrhythmia
NCT02443623_exc_T92
Condition
Syncope
NCT02443623_exc_T93
Condition
cardiac disease
NCT02443623_exc_T94
Condition
Previous myocardial infarction
NCT02443623_exc_T95
Condition
Angina
NCT02443623_exc_T96
Condition
Coronary artery disease
NCT02443623_exc_T97
Condition
Congestive heart failure
NCT02443623_exc_T98
Condition
Cardiomyopathy
NCT02443623_exc_T99
Condition
transient ischemic attack
NCT02443623_exc_T100
Condition
Stroke
NCT02443623_exc_T101
Condition
Myocarditis
NCT02443623_exc_T102
Condition
Pericarditis
NCT02443623_exc_T103
Condition
Chest pain
NCT02443623_exc_T104
Condition
shortness of breath with activity
NCT02443623_exc_T105
Condition
peripheral edema
NCT02443623_exc_T106
Condition
heart palpitations
NCT02443623_exc_T107
Condition
dry cough
NCT02443623_exc_T108
Condition
irregular heartbeat
NCT02443623_exc_T109
Condition
excessive fatigue
NCT02443623_exc_T110
Condition
syncope
NCT02443623_exc_T111
Condition
Other heart conditions
NCT02443623_exc_T47
Person
female
NCT02443623_exc_T112
Observation
childbearing potential
NCT02443623_exc_T113
Value
negative
NCT02443623_exc_T114
Measurement
pregnancy test
NCT02443623_exc_T115
Temporal
prior to vaccination
NCT02443623_exc_T116
Procedure
vaccination
NCT02443623_exc_T117
Reference_point
vaccination
NCT02443623_exc_T118
Scope
female subjects of childbearing potential