Patients with a histologically or cytologically proven diagnosis of NSCLC 
Unresectable (locally advanced) stage IIIa or IIIb disease 
Initial radiotherapy field of treatment to encompass greater than or equal to 30% of the esophagus 
Life expectancy greater than or equal to 6 months 
Estimated weight loss less than or equal to 10% in the 3 months before study randomization 
Measurable disease 
18 years of age or older 
Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 2 
Hemoglobin (hgb) greater than or equal to 10 g/dL without transfusional support or growth factor use in the 4 weeks before study randomization 
Absolute neutrophil count (ANC) greater than or equal to 1.5 x 10^9/L without growth factor use in the 2 weeks before study randomization 
Platelet count greater than or equal to 100 x 10^9/L 
Serum bilirubin less than or equal to 1.5 x institutional upper limit of normal (ULN) 
Serum creatinine less than or equal to 2.0 mg/dL (Note: Patients with a serum creatinine greater than or equal to 1.4 and less than or equal to 2.0 mg/dL must demonstrate a 24-hour urinary creatinine clearance greater than or equal to 50 mL/min) 
Females of childbearing potential: negative serum or urine pregnancy test 
Patient must give written informed consent before participating in any study-specific procedure, randomization, or receiving investigational product. 
Patients with reproductive capability must agree to practice adequate contraception methods. 

NCT00094861_inc_T1
Condition
NSCLC
NCT00094861_inc_T2
Qualifier
cytologically proven
NCT00094861_inc_T3
Qualifier
histologically proven
NCT00094861_inc_T4
Scope
histologically or cytologically proven
NCT00094861_inc_T5
Condition
stage IIIb disease
NCT00094861_inc_T6
Condition
stage IIIa disease
NCT00094861_inc_T7
Qualifier
Unresectable
NCT00094861_inc_T8
Qualifier
locally advanced
NCT00094861_inc_T9
Scope
stage IIIa or IIIb disease
NCT00094861_inc_T10
Qualifier
esophagus
NCT00094861_inc_T11
Multiplier
greater than 30
NCT00094861_inc_T12
Multiplier
equal to 30%
NCT00094861_inc_T13
Scope
greater than or equal to 30%
NCT00094861_inc_T14
Measurement
radiotherapy
NCT00094861_inc_T15
Qualifier
Initial
NCT00094861_inc_T16
Observation
Life expectancy
NCT00094861_inc_T17
Value
equal to 6 months
NCT00094861_inc_T18
Value
greater than 6 months
NCT00094861_inc_T19
Scope
greater than or equal to 6 months
NCT00094861_inc_T20
Condition
Measurable disease
NCT00094861_inc_T21
Temporal
3 months before study randomization
NCT00094861_inc_T22
Reference_point
study randomization
NCT00094861_inc_T23
Measurement
Estimated weight loss
NCT00094861_inc_T24
Value
equal to 10%
NCT00094861_inc_T25
Value
less than 10%
NCT00094861_inc_T26
Scope
less than or equal to 10%
NCT00094861_inc_T28
Measurement
Eastern Cooperative Oncology Group performance status
NCT00094861_inc_T29
Measurement
ECOG
NCT00094861_inc_T30
Value
0 - 2
NCT00094861_inc_T31
Measurement
Hemoglobin
NCT00094861_inc_T32
Measurement
hgb
NCT00094861_inc_T33
Value
equal to 10 g/dL
NCT00094861_inc_T34
Value
greater than 10 g/dL
NCT00094861_inc_T35
Scope
greater than or equal to 10 g/dL
NCT00094861_inc_T36
Temporal
in the 4 weeks before study randomization
NCT00094861_inc_T37
Reference_point
study randomization
NCT00094861_inc_T38
Negation
without
NCT00094861_inc_T39
Observation
transfusional support
NCT00094861_inc_T40
Observation
growth factor use
NCT00094861_inc_T41
Scope
transfusional support or growth factor use
NCT00094861_inc_T42
Measurement
Absolute neutrophil count
NCT00094861_inc_T43
Measurement
ANC
NCT00094861_inc_T44
Value
equal to 1.5 x 10^9/L
NCT00094861_inc_T45
Value
greater than 1.5 x 10^9/L
NCT00094861_inc_T46
Scope
greater than or equal to 1.5 x 10^9/L
NCT00094861_inc_T47
Negation
without
NCT00094861_inc_T48
Observation
growth factor use
NCT00094861_inc_T49
Temporal
in the 2 weeks before study randomization
NCT00094861_inc_T50
Reference_point
study randomization
NCT00094861_inc_T51
Measurement
Platelet count
NCT00094861_inc_T52
Value
greater than 100 x 10^9/L
NCT00094861_inc_T53
Value
equal to 100 x 10^9/L
NCT00094861_inc_T54
Scope
greater than or equal to 100 x 10^9/L
NCT00094861_inc_T55
Measurement
Serum bilirubin
NCT00094861_inc_T56
Value
equal to 1.5 x institutional upper limit of normal (ULN)
NCT00094861_inc_T57
Value
less than 1.5 x institutional upper limit of normal (ULN)
NCT00094861_inc_T58
Scope
less than or equal to 1.5 x institutional upper limit of normal (ULN)
NCT00094861_inc_T59
Measurement
Serum creatinine
NCT00094861_inc_T60
Value
equal to 2.0 mg/dL
NCT00094861_inc_T61
Value
less than
NCT00094861_inc_T62
Value
2.0 mg/dL
NCT00094861_inc_T63
Scope
ess than or equal to 2.0 mg/dL
NCT00094861_inc_T64
Measurement
serum creatinine
NCT00094861_inc_T65
Value
equal to 1.4 mg/dL
NCT00094861_inc_T66
Value
greater than 1.4 mg/dL
NCT00094861_inc_T67
Value
less than 2.0 mg/dL
NCT00094861_inc_T68
Value
equal to 2.0 mg/dL
NCT00094861_inc_T69
Scope
greater than or equal to 1.4 and less than or equal to 2.0 mg/dL
NCT00094861_inc_T70
Measurement
24-hour urinary creatinine clearance
NCT00094861_inc_T71
Value
equal to 50 mL/min
NCT00094861_inc_T72
Value
greater than 50 mL/min
NCT00094861_inc_T73
Scope
greater than or equal to 50 mL/min
NCT00094861_inc_T74
Scope
Serum creatinine less than or equal to 2.0 mg/dL
NCT00094861_inc_T75
Scope
serum creatinine greater than or equal to 1.4 and less than or equal to 2.0 mg/dL must demonstrate a 24-hour urinary creatinine clearance greater than or equal to 50 mL/min
NCT00094861_inc_T76
Person
Females
NCT00094861_inc_T77
Condition
childbearing potential
NCT00094861_inc_T78
Measurement
urine pregnancy test
NCT00094861_inc_T79
Measurement
serum pregnancy test
NCT00094861_inc_T80
Scope
serum or urine pregnancy test
NCT00094861_inc_T81
Value
negative
NCT00094861_inc_T82
Observation
informed consent
NCT00094861_inc_T84
Temporal
before participating in any study-specific procedure, randomization, or receiving investigational product
NCT00094861_inc_T85
Reference_point
participating in any study-specific procedure, randomization, or receiving investigational product
NCT00094861_inc_T86
Qualifier
study-specific
NCT00094861_inc_T87
Procedure
procedure
NCT00094861_inc_T88
Procedure
randomization
NCT00094861_inc_T89
Drug
investigational product
NCT00094861_inc_T90
Scope
study-specific procedure, randomization, or receiving investigational product
NCT00094861_inc_T83
Qualifier
adequate
NCT00094861_inc_T91
Procedure
contraception methods
NCT00094861_inc_T92
Condition
reproductive capability
NCT00094861_inc_T27
Value
18 years or older
NCT00094861_inc_T93
Person
age