A previous history of intolerance to the study drug or related compounds and additives
History of alcoholism, drug abuse, psychiatric, psychological or other emotional problems that are likely to invalidate informed consent
Sleep apnoea
Chronic obstructive pulmonary disease
BMI = 35 or weight < 50 kg
SpO2 < 90 %
Concomitant drug therapy known to cause significant enzyme induction or inhibition of CYP 3A4.
Pregnancy or nursing.

NCT01604187_exc_T1
Observation
previous history
NCT01604187_exc_T2
Condition
intolerance
NCT01604187_exc_T3
Drug
study drug
NCT01604187_exc_T4
Drug
related compounds
NCT01604187_exc_T5
Scope
study drug or related compounds
NCT01604187_exc_T6
Condition
alcoholism
NCT01604187_exc_T7
Condition
drug abuse
NCT01604187_exc_T8
Condition
sychiatric, roblems
NCT01604187_exc_T9
Condition
sychological roblems
NCT01604187_exc_T10
Condition
emotional problems
NCT01604187_exc_T11
Condition
Sleep apnoea
NCT01604187_exc_T12
Condition
Chronic obstructive pulmonary disease
NCT01604187_exc_T13
Measurement
BMI
NCT01604187_exc_T14
Value
= 35
NCT01604187_exc_T15
Measurement
weight
NCT01604187_exc_T16
Value
< 50 kg
NCT01604187_exc_T17
Measurement
SpO2
NCT01604187_exc_T18
Value
< 90 %
NCT01604187_exc_T19
Measurement
drug therapy
NCT01604187_exc_T20
Temporal
Concomitant
NCT01604187_exc_T21
Observation
 induction or i  3A4.
Pre
NCT01604187_exc_T22
Observation
 indu tion of CYP 3A4.
Preg
NCT01604187_exc_T23
Scope
enzyme induction or inhibition of CYP 3A4
NCT01604187_exc_T24
Condition
Pregnancy
NCT01604187_exc_T25
Condition
nursing