Pregnancy or lactating
Allergy to NAC
History of chronic pain
Use of opioids or neuropathic analgesics
Use of NAC prior to trial (< 1 month of planned surgery)
Alcoholism
Diabetes Mellitus (insulin therapy)
Asthma or Chronic Obstructive pulmonary Disease
Known renal function disorders (MDRD <ô0)
Known liver failure (bilirubin >1.Sx upper limit of normal)
No written lC by patient

NCT03354572_exc_T1
Condition
Pregnancy
NCT03354572_exc_T2
Condition
lactating
NCT03354572_exc_T3
Condition
Allergy
NCT03354572_exc_T4
Drug
NAC
NCT03354572_exc_T5
Condition
chronic pain
NCT03354572_exc_T6
Observation
History
NCT03354572_exc_T7
Drug
opioids
NCT03354572_exc_T8
Drug
neuropathic analgesics
NCT03354572_exc_T9
Drug
NAC
NCT03354572_exc_T10
Temporal
prior to trial
NCT03354572_exc_T11
Reference_point
trial
NCT03354572_exc_T12
Temporal
< 1 month
NCT03354572_exc_T13
Mood
planned
NCT03354572_exc_T14
Procedure
surgery
NCT03354572_exc_T15
Scope
< 1 month of planned surgery
NCT03354572_exc_T16
Condition
Alcoholism
NCT03354572_exc_T17
Condition
Diabetes Mellitus
NCT03354572_exc_T18
Drug
insulin
NCT03354572_exc_T19
Condition
Asthma
NCT03354572_exc_T20
Condition
Chronic Obstructive pulmonary Disease
NCT03354572_exc_T21
Condition
renal function disorders
NCT03354572_exc_T22
Measurement
MDRD
NCT03354572_exc_T23
Value
<ô0
NCT03354572_exc_T24
Scope
MDRD <ô0
NCT03354572_exc_T25
Condition
liver failure
NCT03354572_exc_T26
Measurement
bilirubin
NCT03354572_exc_T27
Value
>1.Sx upper limit of normal
NCT03354572_exc_T28
Scope
bilirubin >1.Sx upper limit of normal