Male and/or female patients from 30-80 years of age with a diagnosis of Type 2 diabetes (WHO criteria). 
Incipient and established diabetic nephropathy (urinary albumin excretion ≥ 100 mg/day but ≤ 2000 mg/day). 
Glomerular filtration rate (GFR) ≥ 40 ml/min (estimated using Modification of Diet in Renal Disease (MDRD) formula) in the last 4 months. 
Female patients must be postmenopausal or must have had a bilateral oophorectomy or must have been surgically sterilized or hysterectomized at least 6 months prior to screening. 
To be eligible patients must fulfill the following criteria: Patients on ongoing hypertensive therapy must have a blood pressure ≥ 135/85 mm Hg but lower than 170/105 mm Hg at baseline (Day -1) AND patients must be on stable antihypertensive medications for at least 8 weeks prior to baseline (Day -1).; Newly diagnosed hypertensive patients must have a blood pressure ≥ 135/85 mm Hg but lower than 170/105 mm Hg at baseline (Day -1). 
Patients must be on stable hypoglycemic medications for at least 8 weeks prior to Visit 2 ( Day -1). 
Patients must be willing and medically able to discontinue all Angiotensin-converting enzyme inhibitor (ACEI), Angiotensin receptor blocker (ARB), aldosterone receptor antagonist and potassium sparing diuretic medications for the duration of the study. 
Oral body temperature within the range 35.0-37.5 °C 
Able to provide written informed consent prior to study participation. . 
Able to communicate well with the investigator and comply with the requirements of the study. 

NCT00461136_inc_T1
Value
30-80 years
NCT00461136_inc_T3
Condition
Type 2 diabetes
NCT00461136_inc_T4
Condition
diabetic nephropathy
NCT00461136_inc_T7
Value
≤ 2000 mg/day
NCT00461136_inc_T2
Person
of age
NCT00461136_inc_T5
Value
≥ 100 mg/day
NCT00461136_inc_T6
Measurement
urinary albumin excretion
NCT00461136_inc_T8
Scope
urinary albumin excretion ≥ 100 mg/day but ≤ 2000 mg/day
NCT00461136_inc_T9
Measurement
Glomerular filtration rate (GFR)
NCT00461136_inc_T10
Value
≥ 40 ml/min
NCT00461136_inc_T11
Qualifier
Modification of Diet in Renal Disease (MDRD) formula
NCT00461136_inc_T12
Temporal
in the last 4 months
NCT00461136_inc_T13
Person
Female
NCT00461136_inc_T14
Condition
postmenopausal
NCT00461136_inc_T15
Procedure
bilateral oophorectomy
NCT00461136_inc_T16
Procedure
surgically sterilized
NCT00461136_inc_T17
Procedure
hysterectomized
NCT00461136_inc_T18
Temporal
at least 6 months prior to screening
NCT00461136_inc_T19
Scope
surgically sterilized or hysterectomized
NCT00461136_inc_T20
Scope
postmenopausal or must have had a bilateral oophorectomy or must have been surgically sterilized or hysterectomized at least 6 months prior to screening
NCT00461136_inc_T21
Procedure
hypertensive therapy
NCT00461136_inc_T22
Measurement
blood pressure
NCT00461136_inc_T23
Value
≥ 135/85 mm Hg
NCT00461136_inc_T24
Value
lower than 170/105 mm Hg
NCT00461136_inc_T25
Scope
≥ 135/85 mm Hg but lower than 170/105 mm Hg
NCT00461136_inc_T26
Drug
antihypertensive medications
NCT00461136_inc_T27
Qualifier
stable
NCT00461136_inc_T28
Temporal
at least 8 weeks prior to baseline
NCT00461136_inc_T29
Qualifier
Newly diagnosed
NCT00461136_inc_T30
Condition
hypertensive patients
NCT00461136_inc_T31
Measurement
blood pressure
NCT00461136_inc_T32
Value
≥ 135/85 mm Hg
NCT00461136_inc_T33
Value
lower than 170/105 mm Hg
NCT00461136_inc_T34
Scope
≥ 135/85 mm Hg but lower than 170/105 mm Hg
NCT00461136_inc_T35
Drug
hypoglycemic medications
NCT00461136_inc_T36
Temporal
at least 8 weeks prior to Visit 2
NCT00461136_inc_T37
Qualifier
stable
NCT00461136_inc_T39
Measurement
Oral body temperature
NCT00461136_inc_T40
Value
35.0-37.5 °C
NCT00461136_inc_T43
Scope
Newly diagnosed hypertensive patients
NCT00461136_inc_T44
Temporal
at baseline (Day -1)
NCT00461136_inc_T45
Reference_point
baseline (Day -1)
NCT00461136_inc_T46
Reference_point
baseline
NCT00461136_inc_T47
Reference_point
Visit 2
NCT00461136_inc_T41
Observation
written informed consent
NCT00461136_inc_T48
Temporal
prior to study participation
NCT00461136_inc_T49
Reference_point
study participation
NCT00461136_inc_T42
Observation
Able to communicate well
NCT00461136_inc_T50
Observation
comply with the requirements of the study