History of neuropathy
Regularly taking prescribed analgesia
History of a chronic pain condition
History of severe mental illness (as their experience of symptoms may already be altered)
Current use of fibrates (because of the risk of interaction with statins but will not exclude participants taking ezetimibe).
Severe previous reaction or reaction considered immunological, such as anaphylaxis, facial swelling, severe rash, muscle ache with rise in serum creatine kinase, inflammatory myopathy, rhabdomyolysis or liver function abnormalities (aspartate transaminase (AST) or alanine transaminase (ALT) greater than 3 times upper limit or normal).
Side-effects taking longer than 2 weeks to develop (because in such participants much longer blocks of treatment would be required, if the present study is positive such studies will be planned for the future)*.
History of statin intolerance with drug interaction to antiretroviral drugs.
History of statin intolerance to any other drug.
Pregnant or breast feeding.
Side effects taking longer than 2 weeks to present.
In clinical judgement of study doctor, participant should not participate.

NCT02668016_exc_T1
Condition
neuropathy
NCT02668016_exc_T2
Drug
analgesia
NCT02668016_exc_T3
Qualifier
Regularly
NCT02668016_exc_T4
Condition
chronic pain
NCT02668016_exc_T5
Condition
mental illness
NCT02668016_exc_T6
Qualifier
severe
NCT02668016_exc_T7
Drug
fibrates
NCT02668016_exc_T8
Condition
anaphylaxis
NCT02668016_exc_T9
Condition
facial swelling,
NCT02668016_exc_T10
Condition
severe rash
NCT02668016_exc_T11
Condition
muscle ache
NCT02668016_exc_T12
Measurement
serum creatine kinase
NCT02668016_exc_T13
Value
rise
NCT02668016_exc_T14
Condition
inflammatory myopathy
NCT02668016_exc_T15
Condition
rhabdomyolysis
NCT02668016_exc_T16
Condition
liver function abnormalities
NCT02668016_exc_T17
Measurement
aspartate transaminase
NCT02668016_exc_T18
Measurement
AST
NCT02668016_exc_T19
Measurement
alanine transaminase
NCT02668016_exc_T20
Measurement
ALT
NCT02668016_exc_T21
Value
greater than 3 times upper limit or normal
NCT02668016_exc_T22
Scope
aspartate transaminase (AST) or alanine transaminase (ALT)
NCT02668016_exc_T24
Condition
intolerance
NCT02668016_exc_T25
Drug
statin
NCT02668016_exc_T26
Drug
antiretroviral drugs
NCT02668016_exc_T27
Condition
intolerance
NCT02668016_exc_T28
Drug
statin