Adult (= 18 years old) subjects with chronic genotype 1 HCV and NCI with a GDS greater than or equal to 0.5 (n=60).
Presence of chronic HCV infection based on chart review will be defined as positive for anti-HCV antibody or HCV RNA at least 6 months before screening.
For the HIV/HCV co-infected group only, subjects must have HIV. HIV status will be obtained through self report. Self report will be confirmed at screening using a HIV-1 point of care test. In the event that point of care test and self-report are discordant, then HIV status will be confirmed by a licensed Western blot or a second antibody test.
HIV/HCV co-infected subjects (n=12) must also have a HIV RNA measurement <50 copies/mL at the pre-treatment visit.
Platelets >150,000
Aspartate aminotransferase (AST)/Alanine aminotransferase (ALT) <10x upper limit of normal
Creatinine clearance >30 milliliters/minute/1.73 centimeter squared

NCT02650024_inc_T1
Person
Adult
NCT02650024_inc_T2
Value
= 18 years old
NCT02650024_inc_T3
Person
old
NCT02650024_inc_T4
Qualifier
genotype 1
NCT02650024_inc_T5
Temporal
chronic
NCT02650024_inc_T6
Condition
HCV
NCT02650024_inc_T7
Condition
NCI
NCT02650024_inc_T8
Measurement
GDS
NCT02650024_inc_T9
Value
greater than or equal to 0.5
NCT02650024_inc_T10
Scope
HCV and NCI
NCT02650024_inc_T11
Temporal
chronic
NCT02650024_inc_T12
Condition
HCV infection
NCT02650024_inc_T13
Measurement
anti-HCV antibody
NCT02650024_inc_T14
Value
positive
NCT02650024_inc_T15
Measurement
HCV RNA
NCT02650024_inc_T16
Scope
anti-HCV antibody or HCV RNA
NCT02650024_inc_T17
Temporal
at least 6 months before screening
NCT02650024_inc_T19
Condition
HIV
NCT02650024_inc_T20
Condition
HCV
NCT02650024_inc_T21
Condition
co-infected
NCT02650024_inc_T22
Measurement
HIV RNA measurement
NCT02650024_inc_T23
Value
<50 copies/mL
NCT02650024_inc_T24
Temporal
at the pre-treatment visit
NCT02650024_inc_T25
Measurement
Platelets
NCT02650024_inc_T26
Scope
HIV/HCV co-infected
NCT02650024_inc_T27
Value
>150,000
NCT02650024_inc_T28
Measurement
Aspartate aminotransferase (AST)
NCT02650024_inc_T29
Measurement
Alanine aminotransferase (ALT)
NCT02650024_inc_T30
Value
<10x upper limit of normal
NCT02650024_inc_T31
Measurement
Creatinine clearance
NCT02650024_inc_T32
Value
>30 milliliters/minute/1.73 centimeter squared