Male & female patients >= 18 and < 70 years of age
Positive HBeAg before starting NA treatment
Treated by a single NA (lamivudine, adefovir, entecavir or tenofovir) for 6 months to 5 years
Developed HBeAg seroconversion (HBeAg negative and ant-HBe negative) with undetectable HBV DNA by PCR based assay on NA treatment.
Negative urine or serum pregnancy test (for women of childbearing potential) documented within the 24-hour period prior to the first dose of test drug. Additionally, all females must be using reliable contraception during the study and for 3 months after treatment completion

NCT02068365_inc_T1
Person
Male
NCT02068365_inc_T2
Person
female
NCT02068365_inc_T3
Value
>= 18 and < 70 years
NCT02068365_inc_T4
Person
age
NCT02068365_inc_T5
Measurement
HBeAg
NCT02068365_inc_T6
Value
Positive
NCT02068365_inc_T7
Temporal
before starting NA treatment
NCT02068365_inc_T8
Reference_point
starting NA treatment
NCT02068365_inc_T9
Drug
lamivudine
NCT02068365_inc_T10
Drug
adefovir
NCT02068365_inc_T11
Drug
entecavir
NCT02068365_inc_T12
Drug
tenofovir
NCT02068365_inc_T13
Multiplier
single
NCT02068365_inc_T14
Drug
NA
NCT02068365_inc_T15
Procedure
Treated
NCT02068365_inc_T16
Scope
lamivudine, adefovir, entecavir or tenofovir
NCT02068365_inc_T17
Temporal
for 6 months to 5 years
NCT02068365_inc_T18
Measurement
HBeAg
NCT02068365_inc_T19
Value
seroconversion
NCT02068365_inc_T20
Measurement
HBeAg
NCT02068365_inc_T21
Measurement
ant-HBe
NCT02068365_inc_T22
Value
negative
NCT02068365_inc_T23
Value
negative
NCT02068365_inc_T24
Scope
HBeAg negative and ant-HBe negative
NCT02068365_inc_T25
Value
undetectable
NCT02068365_inc_T26
Measurement
HBV DNA
NCT02068365_inc_T27
Procedure
PCR based assay
NCT02068365_inc_T28
Drug
NA
NCT02068365_inc_T29
Procedure
treatment
NCT02068365_inc_T30
Value
Negative
NCT02068365_inc_T31
Measurement
serum pregnancy test
NCT02068365_inc_T32
Measurement
e or nancy test (fo
NCT02068365_inc_T33
Scope
urine or serum pregnancy test
NCT02068365_inc_T34
Person
women
NCT02068365_inc_T35
Condition
childbearing potential
NCT02068365_inc_T36
Scope
women of childbearing potential
NCT02068365_inc_T37
Temporal
within the 24-hour period prior to the first dose of test drug
NCT02068365_inc_T38
Reference_point
the first dose of test drug