1. Cognitive impairment from mild to moderate degree defined by a Clinical Deterioration Rating (CDR) score range between 0.5 and 2.0. 
2. Evidence on brain MRI of white matter hyperintensities (leukoaraiosis of moderate or severe degree according to the modified Fazekas visual scale and/or presence of lacunar infarcts). 
3. Consent to participation in the study. 

NCT03228498_inc_T1
Condition
Cognitive impairment
NCT03228498_inc_T3
Qualifier
mild to moderate
NCT03228498_inc_T2
Measurement
Clinical Deterioration Rating (CDR) score
NCT03228498_inc_T4
Value
range between 0.5 and 2.0
NCT03228498_inc_T5
Procedure
brain MRI
NCT03228498_inc_T6
Observation
white matter hyperintensities
NCT03228498_inc_T7
Condition
leukoaraiosis
NCT03228498_inc_T8
Value
moderate or severe degree
NCT03228498_inc_T9
Measurement
modified Fazekas visual scale
NCT03228498_inc_T10
Condition
lacunar infarcts
NCT03228498_inc_T11
Scope
leukoaraiosis of moderate or severe degree according to the modified Fazekas visual scale and/or presence of lacunar infarcts