Cohort 1: Recurrent or refractory medulloblastoma in which current standard treatment approaches have failed; biopsy is not required for recurrent disease. 
Cohort 2: Newly-diagnosed high-grade glioma (World Health Organization [WHO] grade 3 or 4) 
Life expectancy ≥ 3 months 

NCT00404495_inc_T1
Condition
refractory medulloblastoma
NCT00404495_inc_T2
Condition
Recurrent medulloblastoma
NCT00404495_inc_T3
Procedure
standard treatment
NCT00404495_inc_T4
Qualifier
failed
NCT00404495_inc_T5
Scope
Recurrent or refractory medulloblastoma
NCT00404495_inc_T6
Condition
high-grade glioma
NCT00404495_inc_T7
Measurement
World Health Organization [WHO] grade
NCT00404495_inc_T8
Value
3 or 4
NCT00404495_inc_T9
Measurement
Life expectancy
NCT00404495_inc_T10
Value
≥ 3 months
NCT00404495_inc_T11
Mood
not required