history of major systemic illness, including uncontrolled hypertension, diabetes, chronic renal insufficiency, autoimmune diseases or malignancies
history of neurological disorders which might affect sensation such as previous stroke or peripheral neuropathy
history of substance abuse (except painkillers)
heavy smokers (with a daily consumption >20 cigarettes)
pregnancy or lactation
any contraindication for magnetic resonance imaging (MRI)
and any obvious infection or inflammation over a period of at least 1 month before the study.

NCT02747940_exc_T1
Condition
systemic illness
NCT02747940_exc_T2
Qualifier
major
NCT02747940_exc_T3
Condition
hypertension
NCT02747940_exc_T4
Qualifier
uncontrolled
NCT02747940_exc_T5
Condition
diabetes
NCT02747940_exc_T6
Condition
chronic renal insufficiency,
NCT02747940_exc_T7
Condition
autoimmune diseases
NCT02747940_exc_T8
Condition
malignancies
NCT02747940_exc_T9
Scope
uncontrolled hypertension, diabetes, chronic renal insufficiency, autoimmune diseases or malignancies
NCT02747940_exc_T10
Condition
neurological disorders
NCT02747940_exc_T11
Condition
stroke
NCT02747940_exc_T12
Condition
peripheral neuropathy
NCT02747940_exc_T13
Condition
affect sensation
NCT02747940_exc_T14
Scope
stroke or peripheral neuropathy
NCT02747940_exc_T15
Condition
substance abuse
NCT02747940_exc_T16
Negation
except
NCT02747940_exc_T17
Drug
painkillers
NCT02747940_exc_T18
Qualifier
heavy
NCT02747940_exc_T19
Person
smokers
NCT02747940_exc_T20
Observation
cigarettes
NCT02747940_exc_T21
Multiplier
daily consumption >20
NCT02747940_exc_T23
Condition
contraindication
NCT02747940_exc_T24
Procedure
magnetic resonance imaging
NCT02747940_exc_T25
Procedure
MRI
NCT02747940_exc_T26
Condition
infection
NCT02747940_exc_T27
Condition
inflammation
NCT02747940_exc_T28
Temporal
at least 1 month before the study
NCT02747940_exc_T29
Reference_point
study
NCT02747940_exc_T30
Scope
infection or inflammation
NCT02747940_exc_T31
Qualifier
obvious