Rest pain or tissue loss due to PAD (Fontaine stage III and IV),
acute lower extremity ischemic event secondary to thromboembolic disease or acute trauma,
Walking capacity significantly limited by conditions other than claudication including leg (joint/musculoskeletal, neurologic) and systemic (heart, lung disease) pathology,
Current use of either ACE inhibitors or angiotensin II receptor blockers,
Chronic kidney disease with estimated Glomerular Filtration Rate < 30 ml/min/1.73 m2,
History of bilateral severe renal artery stenosis and 7) History of angioedema related to previous ACE-inhibitor treatment or known hypersensitivity to ramipril or other ACE inhibitors.

NCT02842424_exc_T1
Condition
Rest pain
NCT02842424_exc_T2
Condition
tissue loss
NCT02842424_exc_T3
Condition
PAD
NCT02842424_exc_T4
Measurement
Fontaine stage
NCT02842424_exc_T5
Value
III
NCT02842424_exc_T6
Value
IV
NCT02842424_exc_T7
Scope
III and IV
NCT02842424_exc_T8
Scope
Rest pain or tissue loss
NCT02842424_exc_T9
Qualifier
acute
NCT02842424_exc_T10
Qualifier
lower extremity
NCT02842424_exc_T11
Condition
ischemic event
NCT02842424_exc_T12
Qualifier
secondary to thromboembolic disease
NCT02842424_exc_T13
Qualifier
econdary to cute trauma,
NCT02842424_exc_T14
Condition
thromboembolic disease
NCT02842424_exc_T15
Condition
acute trauma
NCT02842424_exc_T16
Scope
secondary to thromboembolic disease or acute trauma
NCT02842424_exc_T17
Measurement
Walking capacity
NCT02842424_exc_T18
Value
significantly limited
NCT02842424_exc_T19
Condition
claudication
NCT02842424_exc_T20
Negation
other than
NCT02842424_exc_T21
Condition
g ( thology,
NCT02842424_exc_T22
Condition
stemic ( thology,
NCT02842424_exc_T23
Qualifier
joint
NCT02842424_exc_T24
Qualifier
musculoskeletal
NCT02842424_exc_T25
Qualifier
neurologic
NCT02842424_exc_T26
Scope
joint/musculoskeletal, neurologic
NCT02842424_exc_T27
Condition
art, sease)
NCT02842424_exc_T28
Condition
lung disease
NCT02842424_exc_T29
Scope
heart, lung disease
NCT02842424_exc_T30
Scope
leg (joint/musculoskeletal, neurologic) and systemic (heart, lung disease) pathology
NCT02842424_exc_T31
Condition
conditions other than claudication
NCT02842424_exc_T32
Qualifier
other than claudication
NCT02842424_exc_T34
Drug
ACE inhibitors
NCT02842424_exc_T33
Temporal
Current use
NCT02842424_exc_T35
Drug
angiotensin II receptor blockers
NCT02842424_exc_T36
Scope
ACE inhibitors or angiotensin II receptor blockers
NCT02842424_exc_T37
Condition
Chronic kidney disease
NCT02842424_exc_T38
Measurement
estimated Glomerular Filtration Rate
NCT02842424_exc_T39
Value
< 30 ml/min/1.73 m2
NCT02842424_exc_T40
Observation
History
NCT02842424_exc_T41
Qualifier
bilateral
NCT02842424_exc_T42
Qualifier
severe
NCT02842424_exc_T43
Condition
renal artery stenosis
NCT02842424_exc_T44
Observation
History
NCT02842424_exc_T45
Condition
angioedema
NCT02842424_exc_T46
Temporal
previous
NCT02842424_exc_T47
Procedure
ACE-inhibitor treatment
NCT02842424_exc_T48
Drug
ACE-inhibitor
NCT02842424_exc_T49
Qualifier
known
NCT02842424_exc_T50
Condition
hypersensitivity
NCT02842424_exc_T51
Drug
ramipril
NCT02842424_exc_T52
Drug
ACE inhibitors
NCT02842424_exc_T53
Scope
ramipril or other ACE inhibitors
NCT02842424_exc_T54
Scope
previous ACE-inhibitor treatment or known hypersensitivity to ramipril or other ACE inhibitors