Children will be excluded if they have a history of developmental delay or inability to communicate the effects of an allergic reaction (non-verbal).
Any contraindication to allergy testing will also result in exclusion
(i.e. history of a severe allergic reaction to skin tests,,
anaphylaxis in the past six weeks,
pregnancy,
child took any antihistamine in the past three days [including diphenhydramine (Benadryl®), cetirizine (Zyrtec®), loratadine (Claritin®), fexofenadine (Allegra®), levocetirizine (Xyzal®), and desloratadine (Clarinex®)] or
child has a history of a condition that requires a beta blocker medicine for cardiac conditions, high blood pressure, migraine headaches, or eye drops for glaucoma (e.g. propranolol, metoprolol, atenolol and Timoptic®, or Betoptic® eye drops).
Children who present to the PED with a rash, vomiting or current asthma symptoms including coughing, wheezing or breathing problems will also be excluded to ensure these do not mask reactions to an oral challenge.
Patients being admitted to the hospital or those who are deemed too acutely ill for participation (triage level 1 or 2 or as determined by the ED patient care team) will be excluded from the study.
During this pilot study, we will exclude non-English speaking families. However, in subsequent studies we will include the non-English speaking population.
Children who are wards of the state, in foster care or police custody or detention will be excluded.
Children with any basal condition (trauma, infection, minor accidents, etc..) will be able to participate in the study provided they and their family are willing and do not meet the above-mentioned exclusion criteria.

NCT03404804_exc_T1
Person
Children
NCT03404804_exc_T2
Condition
developmental delay
NCT03404804_exc_T3
Condition
inability to communicate the effects
NCT03404804_exc_T4
Condition
allergic reaction
NCT03404804_exc_T5
Qualifier
non-verbal
NCT03404804_exc_T6
Condition
contraindication
NCT03404804_exc_T7
Procedure
allergy testing
NCT03404804_exc_T8
Condition
severe allergic reaction
NCT03404804_exc_T9
Procedure
skin tests
NCT03404804_exc_T10
Observation
history
NCT03404804_exc_T11
Condition
anaphylaxis
NCT03404804_exc_T12
Temporal
in the past six weeks
NCT03404804_exc_T13
Condition
pregnancy
NCT03404804_exc_T14
Drug
antihistamine
NCT03404804_exc_T15
Temporal
in the past three days
NCT03404804_exc_T16
Drug
diphenhydramine
NCT03404804_exc_T17
Drug
Benadryl
NCT03404804_exc_T18
Drug
cetirizine
NCT03404804_exc_T19
Drug
Zyrtec
NCT03404804_exc_T20
Drug
loratadine
NCT03404804_exc_T21
Drug
Claritin
NCT03404804_exc_T22
Drug
fexofenadine
NCT03404804_exc_T23
Drug
Allegra
NCT03404804_exc_T24
Drug
levocetirizine
NCT03404804_exc_T25
Drug
Xyzal
NCT03404804_exc_T26
Drug
desloratadine
NCT03404804_exc_T27
Drug
Clarinex
NCT03404804_exc_T28
Scope
diphenhydramine (Benadryl®), cetirizine (Zyrtec®), loratadine (Claritin®), fexofenadine (Allegra®), levocetirizine (Xyzal®), and desloratadine (Clarinex®)
NCT03404804_exc_T29
Drug
beta blocker medicine
NCT03404804_exc_T30
Condition
cardiac conditions
NCT03404804_exc_T31
Condition
high blood pressure
NCT03404804_exc_T32
Condition
migraine headaches
NCT03404804_exc_T33
Condition
glaucoma
NCT03404804_exc_T34
Drug
eye drops
NCT03404804_exc_T35
Drug
propranolol
NCT03404804_exc_T36
Drug
metoprolol
NCT03404804_exc_T37
Drug
atenolol
NCT03404804_exc_T38
Drug
Timoptic
NCT03404804_exc_T39
Drug
Betoptic
NCT03404804_exc_T40
Drug
eye drops
NCT03404804_exc_T41
Scope
cardiac conditions, high blood pressure, migraine headaches
NCT03404804_exc_T42
Scope
propranolol, metoprolol, atenolol and Timoptic®, or Betoptic® eye drops
NCT03404804_exc_T43
Person
Children
NCT03404804_exc_T44
Visit
PED
NCT03404804_exc_T45
Condition
rash
NCT03404804_exc_T46
Condition
vomiting
NCT03404804_exc_T47
Condition
asthma symptoms
NCT03404804_exc_T48
Condition
coughing
NCT03404804_exc_T49
Condition
wheezing
NCT03404804_exc_T50
Condition
breathing problems
NCT03404804_exc_T51
Scope
coughing, wheezing or breathing problems
NCT03404804_exc_T52
Temporal
current
NCT03404804_exc_T54
Observation
non-English speaking
NCT03404804_exc_T56
Observation
wards of the state
NCT03404804_exc_T57
Observation
foster care
NCT03404804_exc_T58
Observation
police custody
NCT03404804_exc_T59
Observation
detention
NCT03404804_exc_T60
Condition
basal condition
NCT03404804_exc_T61
Condition
trauma
NCT03404804_exc_T62
Condition
infection
NCT03404804_exc_T63
Condition
minor accidents
NCT03404804_exc_T64
Scope
trauma, infection, minor accidents