Any significant acute or chronic medical illness or problem, including, but not limited to, diabetes, hypertension, cardiac disease, asthma, chronic obstructive lung disease
Current or recent (last 60 days) tobacco or nicotine use
History of sickle cell trait or disease or any other acquired or hereditary hematological abnormality
History of fainting or other significant adverse reaction during phlebotomy or donation of blood
Known prolonged QTc (or evidence of such at screening) on electrocardiogram defined as >470 ms
Known or suspected illicit drug or alcohol abuse
Known or suspected HIV, Hepatitis B, or Hepatitis C infection
History of thrombophilia or anticoagulant therapy
Pregnancy
Obesity defined as BMI>30
Recent history of blood donation: a) Single whole blood unit donation within the past 8 weeks; b) Double RBC donation by apheresis within the past 16 weeks; or c) Plasma donation by apheresis within the past 4 weeks
Inadequate RBC mass based on TBV <4500 ml (above) or screening Hb <14 g/dL

NCT02918851_exc_T1
Condition
diabetes
NCT02918851_exc_T2
Condition
hypertension
NCT02918851_exc_T3
Condition
cardiac disease
NCT02918851_exc_T4
Condition
asthma
NCT02918851_exc_T5
Condition
chronic obstructive lung disease
NCT02918851_exc_T6
Scope
diabetes, hypertension, cardiac disease, asthma, chronic obstructive lung disease
NCT02918851_exc_T7
Condition
medical illness
NCT02918851_exc_T8
Qualifier
acute
NCT02918851_exc_T9
Qualifier
chronic
NCT02918851_exc_T10
Scope
acute or chronic
NCT02918851_exc_T11
Observation
obacco se
NCT02918851_exc_T12
Observation
nicotine use
NCT02918851_exc_T13
Scope
tobacco or nicotine use
NCT02918851_exc_T14
Temporal
last 60 days
NCT02918851_exc_T15
Condition
sickle cell trait
NCT02918851_exc_T16
Condition
ckle cell t sease o
NCT02918851_exc_T17
Condition
hereditary hematological abnormality
NCT02918851_exc_T18
Condition
quired o matological abnormality
H
NCT02918851_exc_T19
Condition
fainting
NCT02918851_exc_T20
Procedure
phlebotomy
NCT02918851_exc_T21
Condition
adverse reaction
NCT02918851_exc_T22
Observation
donation of blood
NCT02918851_exc_T23
Scope
phlebotomy or donation of blood
NCT02918851_exc_T24
Measurement
QTc
NCT02918851_exc_T25
Procedure
electrocardiogram
NCT02918851_exc_T26
Value
>470 ms
NCT02918851_exc_T27
Condition
it drug or a 
Kno
NCT02918851_exc_T28
Condition
alcohol abuse
NCT02918851_exc_T29
Condition
epa ion
Histo
NCT02918851_exc_T30
Condition
tis B, or H ion
Histo
NCT02918851_exc_T31
Condition
Hepatitis C infection
NCT02918851_exc_T32
Condition
thrombophilia
NCT02918851_exc_T33
Drug
anticoagulant therapy
NCT02918851_exc_T34
Condition
Pregnancy
NCT02918851_exc_T35
Measurement
BMI
NCT02918851_exc_T36
Condition
Obesity
NCT02918851_exc_T37
Value
>30
NCT02918851_exc_T38
Observation
blood donation
NCT02918851_exc_T40
Observation
RBC mass
NCT02918851_exc_T41
Qualifier
Inadequate
NCT02918851_exc_T42
Measurement
TBV
NCT02918851_exc_T43
Value
<4500 ml
NCT02918851_exc_T44
Measurement
Hb
NCT02918851_exc_T45
Value
<14 g/dL
NCT02918851_exc_T46
Scope
TBV <4500 ml (above) or screening Hb <14 g/dL