Patients with a history of allergy or hypersensitivity to tramadol.
History of epilepsy or convulsions due to any reason.
Chronic usage of analgesic drugs.
Patients using monoamine oxidase inhibitors.
Patients with clinical signs of raised ICP.
Obesity (women with a body mass index >35 kg/m2 or men with a body mass index >42 kg/m2)
Language barrier.
Patients taking B-blockers or Ca channel blockers.
Patients above 65 years of age ( Physiology difference)

NCT02964416_exc_T1
Condition
allergy
NCT02964416_exc_T2
Condition
hypersensitivity
NCT02964416_exc_T3
Drug
tramadol
NCT02964416_exc_T4
Scope
allergy or hypersensitivity
NCT02964416_exc_T5
Condition
epilepsy
NCT02964416_exc_T6
Condition
convulsions
NCT02964416_exc_T7
Drug
analgesic drugs
NCT02964416_exc_T8
Drug
monoamine oxidase inhibitors
NCT02964416_exc_T9
Measurement
ICP
NCT02964416_exc_T10
Value
raised
NCT02964416_exc_T11
Condition
Obesity
NCT02964416_exc_T12
Person
women
NCT02964416_exc_T13
Measurement
body mass index
NCT02964416_exc_T14
Value
>35 kg/m2
NCT02964416_exc_T15
Person
men
NCT02964416_exc_T16
Measurement
body mass index
NCT02964416_exc_T17
Value
>42 kg/m2
NCT02964416_exc_T18
Scope
women with a body mass index >35 kg/m2 or men with a body mass index >42 kg/m2
NCT02964416_exc_T20
Drug
Ca channel blockers
NCT02964416_exc_T21
Drug
B-blockers
NCT02964416_exc_T22
Person
age
NCT02964416_exc_T23
Value
above 65 years