Patients with Ph (BCR/ABL) positive de novo < 55 years old (it is advisable to include patients over 55 years LAL07OPH protocol).
Performance status 0-2 (Appendix B) may include patients with performance status > 2 attributable to LAL.
Patients without functional impairment of organs: liver function: total bilirubin, AST, ALT, alfa-GT and alkaline phosphatase less than 3 times the upper limit of normal laboratory renal function: serum creatinine < 2 mg/dL or clearance creatinine > 30 ml/min (except renal function attributable to LAL) cardiac function (Appendix B) normal: ventricular EF > 50%, absence of severe chronic respiratory disease. In the event that alterations are secondary to the disease is at the discretion of the investigator to determine if the patient can be included in the trial.

NCT01491763_inc_T1
Measurement
Ph (BCR/ABL)
NCT01491763_inc_T2
Value
positive
NCT01491763_inc_T3
Qualifier
de novo
NCT01491763_inc_T4
Value
< 55 years
NCT01491763_inc_T5
Person
old
NCT01491763_inc_T7
Measurement
Performance status
NCT01491763_inc_T8
Value
0-2
NCT01491763_inc_T10
Condition
functional impairment of organs
NCT01491763_inc_T11
Negation
without
NCT01491763_inc_T12
Measurement
total bilirubin
NCT01491763_inc_T13
Measurement
AST
NCT01491763_inc_T14
Measurement
ALT
NCT01491763_inc_T15
Measurement
alfa-GT
NCT01491763_inc_T16
Measurement
alkaline phosphatase
NCT01491763_inc_T17
Value
less than 3 times the upper limit of normal
NCT01491763_inc_T18
Scope
total bilirubin, AST, ALT, alfa-GT and alkaline phosphatase
NCT01491763_inc_T19
Scope
total bilirubin, AST, ALT, alfa-GT and alkaline phosphatase less than 3 times the upper limit of normal
NCT01491763_inc_T20
Scope
without functional impairment of organs
NCT01491763_inc_T21
Measurement
serum creatinine
NCT01491763_inc_T22
Value
< 2 mg/dL
NCT01491763_inc_T23
Measurement
clearance creatinine
NCT01491763_inc_T24
Value
> 30 ml/min
NCT01491763_inc_T26
Measurement
cardiac function
NCT01491763_inc_T27
Value
normal
NCT01491763_inc_T28
Measurement
ventricular EF
NCT01491763_inc_T29
Value
> 50%
NCT01491763_inc_T30
Negation
absence of
NCT01491763_inc_T31
Condition
severe chronic respiratory disease
NCT01491763_inc_T32
Scope
cardiac function (Appendix B) normal
NCT01491763_inc_T33
Scope
ventricular EF > 50%
NCT01491763_inc_T35
Scope
total bilirubin, AST, ALT, alfa-GT and alkaline phosphatase less than 3 times the upper limit of normal laboratory renal function: serum creatinine < 2 mg/dL or clearance creatinine > 30 ml/min (except renal function attributable to LAL) cardiac function (Appendix B) normal: ventricular EF > 50%, absence of severe chronic respiratory disease.