1. Personal history of stroke, brain lesions, previous neurosurgery, any personal history of seizure or fainting episode of unknown cause, or head trauma resulting in loss of consciousness, lasting over 30 minutes or with sequela lasting longer than two days. 
Justification: Stroke or head trauma can lower the seizure threshold, and are therefore contra-indications for TMS. Fainting episodes or syncope of unknown cause could indicate an undiagnosed condition associated with seizures. 
Screening tool: TMS adult safety questionnaire, Medical History. 
2. First-degree family history of any neurological disorder with a potentially hereditary basis, including migraines, epilepsy, or multiple sclerosis. 
1. Justification: Neurological disorders can lower the seizure threshold, and are therefore contra-indications for TMS. First-degree family history of certain neurological disorders with a hereditary component increases the risk of the subject having an undiagnosed condition that is associated with lowered seizure threshold. 
2. Screening tool: TMS adult safety screening, Medical History. 
3. Cardiac pacemakers, neural stimulators, implantable defibrillator, implanted medication pumps, intracardiac lines, or acute, unstable cardiac disease, with intracranial implants (e.g. aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or any other metal object within or near the head that precludes MRI scanning. 
1. Justification: Any metal around the head is a contraindication for both MRI and TMS, as both methods involve exposure to a relatively strong magnetic field. 
2. Screening tool: TMS adult safety screening, MRI safety screening, Medical History. 
4. Noise-induced hearing loss or tinnitus. 
1. Justification: individuals with noise-induced hearing problems may be particularly vulnerable to the acoustic noise generated by TMS and MRI equipment. 
2. Screening tools: TMS adult safety screening. 
5. Current use (any use in the past 4 weeks, chronic use within 6 past six months) of any investigational drug or of any medications with psychotropic, anti or pro-convulsive action. 
1. Justification: The use of certain medications or drugs can lower seizure threshold and is therefore contra-indicated for TMS. 
2. Screening tools: MRI safety screening questionnaire, Medical history, Medical Assessments: Urine toxicology analyzes for presence of a broad range of prescription and nonprescription drugs. 
6. Lifetime history of major depressive disorder, schizophrenia, bipolar disorder, mania, or hypomania. 
1. Justification: The population of interest here is a healthy control population with no psychiatric disorders. In subjects with depression, bipolar disorder, mania or hypomania, there is a small chance that TMS can trigger (hypo)manic symptoms. 
2. Screening tools: SCID Screen Patient Questionnaire. Potential diagnoses will be further evaluated by a counsellor. 
7. Meet current DSM V criteria for moderate to severe substance use disorder (excluding nicotine), smoke daily, or urine toxicology positive for any illicit substance inconsistent with history given. 
1. Justification: The population of interest here is a healthy control population with no substance use disorder. Current use of illicit substances could impact on seizure threshold and is therefore contra-indicated for TMS. 
2. Screening tools: SCID Screen Patient Questionnaire. Potential diagnoses will be further evaluated by a counsellor, Drug Use Survey (DUS), Substance Use Disorder Evaluation, Medical Assessments: urine qualitative drug screen is performed for methadone, benzodiazepines, cocaine, amphetamine/methamphetamine, opiates, barbiturates, and tetrahydrocannabinol. 
8. Have met DSM V criteria for moderate to severe substance use disorder (excluding nicotine, alcohol and cannabis) in the past, or have met DSM V criteria for moderate to severe substance use disorder for cannabis or alcohol in the past 5 years. 
1. Justification: the population of interest here is a healthy control population with no present or past substance use disorder. 
2. Screening tools: SCID Screen Patient Questionnaire. Potential diagnoses will be further evaluated by a counselor. Drug Use Survey (DUS), Substance Use Disorder Evaluation. 
9. History of myocardial infarction, angina, congestive heart failure, cardiomyopathy, stroke or transient ischemic attack, or any heart condition currently under medical care. 
1. Justifications: the risk of TMS for individuals with a heart condition is unknown. 
2. Screening tool: physical assessment (EKG), medical history. 
10. Pregnant women or women with reproductive potential who are sexually active and not using an acceptable form of contraception. 
1. Justification: it is unknown whether TMS poses a risk to fetuses. 
2. Screening tool: Medical assessments (urine pregnancy test) at the beginning of each visit that involves TMS or MRI. 
11. History of learning disability or current ADHD 
1. Justification: Subjects should be able to perform cognitive tasks to a high degree of accuracy, both in the MRI scanner and outside the scanner. Subjects with ADHD/LD may engage different neural circuitry even if they can perform the tasks. 
2. Screening tool: Wechsler Abbreviated Scale of Intelligence, Medical history, Adult ADHD Self-Report Scale. 
12. Participation in an rTMS session less than two weeks ago. 
1. Justification: in order to limit exposure to TMS, we will not enroll subjects who have received TMS less than two weeks ago. 
2. Screening tool: TMS safety screening questionnaire.       
    

NCT02231892_exc_T35
Procedure
TMS safety screening questionnaire
NCT02231892_exc_T38
Procedure
rTMS session
NCT02231892_exc_T39
Temporal
less than two weeks ago
NCT02231892_exc_T40
Procedure
Wechsler Abbreviated Scale of Intelligence
NCT02231892_exc_T41
Observation
Medical history
NCT02231892_exc_T42
Procedure
Adult ADHD Self-Report Scale
NCT02231892_exc_T45
Condition
ADHD
NCT02231892_exc_T46
Condition
LD
NCT02231892_exc_T52
Condition
learning disability
NCT02231892_exc_T53
Temporal
current
NCT02231892_exc_T54
Observation
History
NCT02231892_exc_T55
Condition
ADHD
NCT02231892_exc_T56
Measurement
urine pregnancy test
NCT02231892_exc_T57
Procedure
Medical assessments
NCT02231892_exc_T58
Temporal
at the beginning of each visit
NCT02231892_exc_T59
Reference_point
the beginning of each visit
NCT02231892_exc_T60
Procedure
TMS
NCT02231892_exc_T61
Procedure
MRI
NCT02231892_exc_T62
Scope
TMS or MRI
NCT02231892_exc_T65
Condition
Pregnant
NCT02231892_exc_T66
Person
women
NCT02231892_exc_T67
Person
women
NCT02231892_exc_T68
Condition
reproductive potential
NCT02231892_exc_T69
Condition
sexually active
NCT02231892_exc_T70
Condition
contraception
NCT02231892_exc_T71
Qualifier
acceptable form of
NCT02231892_exc_T73
Negation
not
NCT02231892_exc_T74
Scope
Pregnant women
NCT02231892_exc_T75
Scope
women with reproductive potential who are sexually active and not using an acceptable form of contraception
NCT02231892_exc_T80
Condition
myocardial infarction
NCT02231892_exc_T81
Condition
angina
NCT02231892_exc_T82
Condition
congestive heart failure
NCT02231892_exc_T83
Condition
cardiomyopathy
NCT02231892_exc_T84
Condition
stroke
NCT02231892_exc_T85
Condition
transient ischemic attack
NCT02231892_exc_T86
Condition
heart condition
NCT02231892_exc_T87
Qualifier
under medical care
NCT02231892_exc_T88
Temporal
currently
NCT02231892_exc_T90
Observation
History
NCT02231892_exc_T91
Scope
myocardial infarction, angina, congestive heart failure, cardiomyopathy, stroke or transient ischemic attack
NCT02231892_exc_T97
Measurement
DSM V criteria
NCT02231892_exc_T98
Qualifier
moderate to severe
NCT02231892_exc_T99
Condition
substance use disorder
NCT02231892_exc_T100
Drug
nicotine
NCT02231892_exc_T101
Negation
excluding
NCT02231892_exc_T102
Observation
smoke daily
NCT02231892_exc_T103
Measurement
urine toxicology
NCT02231892_exc_T104
Value
positive
NCT02231892_exc_T105
Drug
illicit substance
NCT02231892_exc_T106
Qualifier
inconsistent with history
NCT02231892_exc_T112
Value
Meet
NCT02231892_exc_T115
Procedure
Drug Use Survey (DUS)
NCT02231892_exc_T116
Procedure
Substance Use Disorder Evaluation
NCT02231892_exc_T120
Procedure
SCID Screen Patient Questionnaire
NCT02231892_exc_T125
Measurement
DSM V criteria
NCT02231892_exc_T126
Value
met
NCT02231892_exc_T127
Qualifier
moderate to severe
NCT02231892_exc_T128
Condition
substance use disorder
NCT02231892_exc_T129
Drug
nicotine
NCT02231892_exc_T130
Drug
alcohol
NCT02231892_exc_T131
Drug
cannabis
NCT02231892_exc_T132
Negation
excluding
NCT02231892_exc_T133
Temporal
in the past
NCT02231892_exc_T134
Measurement
DSM V criteria
NCT02231892_exc_T135
Value
met
NCT02231892_exc_T136
Scope
excluding nicotine, alcohol and cannabis
NCT02231892_exc_T137
Qualifier
moderate to severe
NCT02231892_exc_T138
Condition
substance use disorder
NCT02231892_exc_T139
Drug
cannabis
NCT02231892_exc_T140
Drug
alcohol
NCT02231892_exc_T141
Temporal
in the past 5 years
NCT02231892_exc_T142
Scope
cannabis or alcohol
NCT02231892_exc_T147
Procedure
SCID Screen Patient Questionnaire
NCT02231892_exc_T148
Observation
history of
NCT02231892_exc_T149
Condition
stroke
NCT02231892_exc_T150
Condition
brain lesions
NCT02231892_exc_T151
Condition
neurosurgery
NCT02231892_exc_T152
Temporal
previous
NCT02231892_exc_T153
Observation
personal history of
NCT02231892_exc_T154
Condition
seizure
NCT02231892_exc_T155
Condition
fainting episode
NCT02231892_exc_T156
Qualifier
unknown cause
NCT02231892_exc_T157
Condition
head trauma resulting in loss of consciousness
NCT02231892_exc_T158
Qualifier
lasting over 30 minutes
NCT02231892_exc_T159
Condition
sequela
NCT02231892_exc_T160
Measurement
lasting
NCT02231892_exc_T161
Value
longer than two days
NCT02231892_exc_T162
Scope
lasting over 30 minutes or with sequela lasting longer than two days
NCT02231892_exc_T163
Scope
seizure or fainting episode of unknown cause, or head trauma resulting in loss of consciousness, lasting over 30 minutes or with sequela lasting longer than two days
NCT02231892_exc_T164
Scope
stroke, brain lesions, previous neurosurgery
NCT02231892_exc_T166
Procedure
TMS adult safety questionnaire
NCT02231892_exc_T167
Observation
Medical History
NCT02231892_exc_T168
Procedure
Screening
NCT02231892_exc_T169
Scope
TMS adult safety questionnaire, Medical History
NCT02231892_exc_T170
Qualifier
First-degree
NCT02231892_exc_T171
Observation
family history of
NCT02231892_exc_T172
Condition
neurological disorder
NCT02231892_exc_T173
Qualifier
potentially hereditary basis
NCT02231892_exc_T174
Condition
migraines
NCT02231892_exc_T175
Condition
epilepsy
NCT02231892_exc_T176
Condition
multiple sclerosis
NCT02231892_exc_T177
Scope
migraines, epilepsy, or multiple sclerosis
NCT02231892_exc_T178
Scope
neurological disorder with a potentially hereditary basis
NCT02231892_exc_T180
Procedure
Screening
NCT02231892_exc_T181
Procedure
TMS adult safety screening
NCT02231892_exc_T182
Observation
Medical History
NCT02231892_exc_T183
Scope
TMS adult safety screening, Medical History
NCT02231892_exc_T184
Device
Cardiac pacemakers
NCT02231892_exc_T185
Device
neural stimulators
NCT02231892_exc_T186
Device
implantable defibrillator
NCT02231892_exc_T187
Device
implanted medication pumps
NCT02231892_exc_T188
Device
intracardiac lines
NCT02231892_exc_T189
Qualifier
acute
NCT02231892_exc_T190
Qualifier
unstable
NCT02231892_exc_T191
Condition
cardiac disease
NCT02231892_exc_T192
Device
intracranial implants
NCT02231892_exc_T193
Device
aneurysm clips
NCT02231892_exc_T194
Device
shunts
NCT02231892_exc_T195
Device
stimulators
NCT02231892_exc_T196
Device
cochlear implants
NCT02231892_exc_T197
Device
electrodes
NCT02231892_exc_T198
Device
metal object within or near the head
NCT02231892_exc_T199
Qualifier
precludes MRI scanning
NCT02231892_exc_T200
Negation
precludes
NCT02231892_exc_T201
Procedure
MRI scanning
NCT02231892_exc_T202
Scope
aneurysm clips, shunts, stimulators, cochlear implants, or electrodes
NCT02231892_exc_T207
Procedure
Screening
NCT02231892_exc_T208
Procedure
TMS adult safety screening
NCT02231892_exc_T209
Procedure
MRI safety screening
NCT02231892_exc_T210
Observation
Medical History
NCT02231892_exc_T211
Scope
TMS adult safety screening, MRI safety screening, Medical History
NCT02231892_exc_T212
Condition
Noise-induced hearing loss
NCT02231892_exc_T213
Condition
tinnitus
NCT02231892_exc_T214
Procedure
Screening
NCT02231892_exc_T215
Procedure
TMS adult safety screening
NCT02231892_exc_T216
Qualifier
Current use
NCT02231892_exc_T217
Temporal
in the past 4 weeks
NCT02231892_exc_T218
Qualifier
any use
NCT02231892_exc_T219
Qualifier
chronic use
NCT02231892_exc_T220
Temporal
within 6 past six months
NCT02231892_exc_T221
Scope
any use in the past 4 weeks, chronic use within 6 past six months
NCT02231892_exc_T222
Temporal
Current use
NCT02231892_exc_T223
Drug
investigational drug
NCT02231892_exc_T224
Drug
medications
NCT02231892_exc_T225
Qualifier
psychotropic action
NCT02231892_exc_T226
Qualifier
pro-convulsive action
NCT02231892_exc_T227
Scope
psychotropic, anti or pro-convulsive action
NCT02231892_exc_T228
Scope
investigational drug or of any medications with psychotropic, anti or pro-convulsive action
NCT02231892_exc_T229
Procedure
Screening
NCT02231892_exc_T230
Procedure
MRI safety screening questionnaire
NCT02231892_exc_T231
Procedure
MRI
NCT02231892_exc_T232
Procedure
safety screening questionnaire
NCT02231892_exc_T233
Procedure
Medical history
NCT02231892_exc_T234
Procedure
Urine toxicology analyzes
NCT02231892_exc_T235
Qualifier
prescription
NCT02231892_exc_T236
Qualifier
nonprescription
NCT02231892_exc_T237
Drug
drugs
NCT02231892_exc_T238
Scope
prescription and nonprescription
NCT02231892_exc_T239
Scope
MRI safety screening questionnaire, Medical history, Medical Assessments: Urine toxicology analyzes for presence of a broad range of prescription and nonprescription drugs
NCT02231892_exc_T240
Observation
Lifetime history of
NCT02231892_exc_T241
Condition
major depressive disorder
NCT02231892_exc_T242
Condition
schizophrenia
NCT02231892_exc_T243
Condition
bipolar disorder
NCT02231892_exc_T244
Condition
mania
NCT02231892_exc_T245
Condition
hypomania
NCT02231892_exc_T246
Scope
major depressive disorder, schizophrenia, bipolar disorder, mania, or hypomania