Cytologically proven acute lymphoblastic leukemia (ALL)
No relapse of a previously unrecognized ALL
Patients must meet one of the following risk criteria:
Standard-risk (SR) group meeting all of the following criteria:
Blasts < 1,000/µL in peripheral blood (PB) on day 8
Aged 1 to < 6 years
Initial WBC < 20,000/µL
M1 (5%) or M2 (= 5% to < 25%) blasts in bone marrow on day 15;
M1 marrow on day 33.
Aged < 1 or = 6 years and/or WBC = 20,000/µL
Blasts < 1,000/µL in PB on day 8
M1 or M2 marrow on day 15
M3 (= 25%) marrow on day 15 OR meets SR criteria but M3 marrow on day 15 and *M1 marrow on day 33.
Meets IR criteria and M3 marrow on day 15 (not SR and M3 on day 15)
Blasts = 1,000/µL in PB on day 8
M2 or M3 marrow on day 33
Translocation t(9;22) [BCR/ABL+] (Philadelphia chromosome-positive) or t(4;11) [MLL/AF4+].

NCT00846703_inc_T1
Condition
acute lymphoblastic leukemia
NCT00846703_inc_T2
Condition
ALL
NCT00846703_inc_T3
Qualifier
Cytologically proven
NCT00846703_inc_T4
Condition
ALL
NCT00846703_inc_T5
Qualifier
previously unrecognized
NCT00846703_inc_T6
Negation
No
NCT00846703_inc_T7
Condition
relapse
NCT00846703_inc_T22
Measurement
Standard-risk
NCT00846703_inc_T23
Measurement
SR
NCT00846703_inc_T24
Multiplier
all
NCT00846703_inc_T25
Measurement
criteria
NCT00846703_inc_T26
Measurement
Blasts
NCT00846703_inc_T27
Value
< 1,000/µL
NCT00846703_inc_T28
Qualifier
peripheral blood
NCT00846703_inc_T29
Qualifier
PB
NCT00846703_inc_T30
Temporal
on day 8
NCT00846703_inc_T31
Person
Aged
NCT00846703_inc_T32
Value
1 to < 6 years
NCT00846703_inc_T33
Measurement
WBC
NCT00846703_inc_T34
Qualifier
Initial
NCT00846703_inc_T35
Value
< 20,000/µL
NCT00846703_inc_T36
Measurement
in bon
NCT00846703_inc_T37
Measurement
% in bon
NCT00846703_inc_T38
Qualifier
bone marrow
NCT00846703_inc_T39
Value
(5%
NCT00846703_inc_T40
Value
= 5% to < 25%
NCT00846703_inc_T41
Temporal
on day 15
NCT00846703_inc_T42
Scope
M1 (5%) or M2 (= 5% to < 25%) blasts
NCT00846703_inc_T43
Condition
M1 marrow
NCT00846703_inc_T44
Temporal
on day 33
NCT00846703_inc_T45
Person
Aged
NCT00846703_inc_T46
Value
< 1 or = 6 years
NCT00846703_inc_T47
Measurement
WBC
NCT00846703_inc_T48
Value
= 20,000/µL
NCT00846703_inc_T49
Measurement
Blasts
NCT00846703_inc_T50
Value
< 1,000/µL
NCT00846703_inc_T51
Condition
PB
NCT00846703_inc_T52
Temporal
on day 8
NCT00846703_inc_T53
Condition
M2 marrow
NCT00846703_inc_T54
Condition
rr ay 15
NCT00846703_inc_T55
Temporal
on day 15
NCT00846703_inc_T56
Scope
M1 or M2 marrow
NCT00846703_inc_T57
Condition
ar y 15 O
NCT00846703_inc_T58
Value
= 25%
NCT00846703_inc_T59
Temporal
on day 15
NCT00846703_inc_T60
Measurement
SR criteria
NCT00846703_inc_T61
Value
meets
NCT00846703_inc_T62
Condition
M3 marrow
NCT00846703_inc_T63
Temporal
on day 15
NCT00846703_inc_T64
Condition
M1 marrow
NCT00846703_inc_T65
Temporal
on day 33
NCT00846703_inc_T66
Scope
meets SR criteria but M3 marrow on day 15 and *M1 marrow on day 33
NCT00846703_inc_T67
Measurement
IR criteria
NCT00846703_inc_T68
Value
Meets
NCT00846703_inc_T69
Condition
M3 marrow
NCT00846703_inc_T70
Temporal
on day 15
NCT00846703_inc_T71
Value
not
NCT00846703_inc_T72
Measurement
SR
NCT00846703_inc_T73
Condition
M3
NCT00846703_inc_T74
Temporal
on day 15
NCT00846703_inc_T75
Measurement
Blasts
NCT00846703_inc_T76
Value
= 1,000/µL
NCT00846703_inc_T77
Qualifier
PB
NCT00846703_inc_T78
Temporal
on day 8
NCT00846703_inc_T79
Condition
M3 marrow
NCT00846703_inc_T80
Condition
3
Tran
NCT00846703_inc_T81
Temporal
on day 33
NCT00846703_inc_T82
Scope
M2 or M3 marrow
NCT00846703_inc_T83
Measurement
Translocation t(9;22)
NCT00846703_inc_T84
Measurement
BCR/ABL
NCT00846703_inc_T85
Value
+
NCT00846703_inc_T86
Measurement
Philadelphia chromosome
NCT00846703_inc_T87
Value
positive
NCT00846703_inc_T88
Measurement
t(4;11)
NCT00846703_inc_T89
Measurement
MLL/AF4
NCT00846703_inc_T90
Value
+