Risk of severe alcohol withdrawal (e.g. history of seizures or delirium tremens)
Current Moderate or Severe Substance Use Disorder, other than Alcohol, Nicotine or Caffeine Use Disorders
Lifetime history of Bipolar Disorder, Schizophrenia or Schizoaffective Disorder
Any current psychiatric disorder, other than Alcohol Use Disorder, that, in the judgment of the investigator, will require treatment that will interfere with study participation.
Current severe depression (HAM-D >24) or anxiety (HAM-A >24)
Significant suicide or violence risk
Currently taking any psychotropic medications
Legally mandated to participate in treatment
History of prior treatment with disulfiram
Sufficiently socially unstable as to preclude participation (e.g. homeless)
Contraindications to disulfiram treatment (liver disease, kidney disease, cardiac disease, seizure disorder, hypothyroidism, diabetes mellitus, pregnancy or lactation, allergy to disulfiram or thiuran derivatives)
Neurological or medical conditions that would interfere with MRI scanning (e.g. history of stroke, seizure, brain tumor, brain infection, traumatic brain injury, multiple sclerosis, dementia, metal device in body, pregnancy, claustrophobia, color blindness, severe hearing impairment, weight>300 lbs., wheelchair-bound)
Currently taking medications containing alcohol, metronidazole, isoniazid, paraldehyde, phenytoin, warfarin, or theophylline.
Significant alcohol withdrawal (CIWA>8) at screening, after confirming a blood alcohol level of zero.

NCT02735577_exc_T1
Qualifier
severe
NCT02735577_exc_T2
Condition
alcohol withdrawal
NCT02735577_exc_T3
Mood
Risk of
NCT02735577_exc_T4
Condition
seizures
NCT02735577_exc_T5
Observation
history
NCT02735577_exc_T6
Condition
delirium tremens
NCT02735577_exc_T7
Scope
seizures or delirium tremens
NCT02735577_exc_T8
Condition
Substance Use Disorder
NCT02735577_exc_T9
Qualifier
Moderate
NCT02735577_exc_T10
Qualifier
Severe
NCT02735577_exc_T11
Temporal
Current
NCT02735577_exc_T12
Scope
Moderate or Severe
NCT02735577_exc_T13
Negation
other than
NCT02735577_exc_T14
Condition
lcohol, se Disorders
NCT02735577_exc_T15
Condition
icotine se Disorders
NCT02735577_exc_T16
Condition
Caffeine Use Disorders
NCT02735577_exc_T17
Scope
Alcohol, Nicotine or Caffeine Use Disorders
NCT02735577_exc_T18
Condition
Bipolar Disorder
NCT02735577_exc_T19
Observation
Lifetime history
NCT02735577_exc_T20
Condition
Schizophrenia
NCT02735577_exc_T21
Condition
Schizoaffective Disorder
NCT02735577_exc_T22
Scope
Bipolar Disorder, Schizophrenia or Schizoaffective Disorder
NCT02735577_exc_T23
Condition
psychiatric disorder
NCT02735577_exc_T24
Temporal
current
NCT02735577_exc_T25
Condition
Alcohol Use Disorder
NCT02735577_exc_T27
Negation
other than
NCT02735577_exc_T28
Temporal
Current
NCT02735577_exc_T29
Qualifier
severe
NCT02735577_exc_T30
Condition
depression
NCT02735577_exc_T31
Measurement
HAM-D
NCT02735577_exc_T32
Value
>24
NCT02735577_exc_T33
Condition
anxiety
NCT02735577_exc_T34
Measurement
HAM-A
NCT02735577_exc_T35
Value
>24
NCT02735577_exc_T36
Qualifier
severe
NCT02735577_exc_T37
Scope
severe depression (HAM-D >24) or anxiety (HAM-A >24)
NCT02735577_exc_T38
Condition
de or v Curr
NCT02735577_exc_T39
Condition
violence risk
NCT02735577_exc_T40
Qualifier
Significant
NCT02735577_exc_T41
Scope
suicide or violence risk
NCT02735577_exc_T42
Drug
psychotropic medications
NCT02735577_exc_T43
Temporal
Currently
NCT02735577_exc_T45
Drug
disulfiram
NCT02735577_exc_T46
Observation
History of prior treatment
NCT02735577_exc_T47
Condition
socially unstable
NCT02735577_exc_T48
Qualifier
Sufficiently
NCT02735577_exc_T49
Condition
Contraindications
NCT02735577_exc_T50
Drug
disulfiram
NCT02735577_exc_T51
Condition
liver disease
NCT02735577_exc_T52
Condition
kidney disease
NCT02735577_exc_T53
Condition
cardiac disease
NCT02735577_exc_T54
Condition
seizure disorder
NCT02735577_exc_T55
Condition
hypothyroidism
NCT02735577_exc_T56
Condition
diabetes mellitus
NCT02735577_exc_T57
Condition
pregnancy
NCT02735577_exc_T58
Condition
lactation
NCT02735577_exc_T59
Condition
allergy
NCT02735577_exc_T60
Drug
disulfiram
NCT02735577_exc_T61
Drug
thiuran derivatives
NCT02735577_exc_T62
Scope
disulfiram or thiuran derivatives
NCT02735577_exc_T63
Scope
liver disease, kidney disease, cardiac disease, seizure disorder, hypothyroidism, diabetes mellitus, pregnancy or lactation, allergy to disulfiram or thiuran derivatives
NCT02735577_exc_T64
Scope
Contraindications to disulfiram
NCT02735577_exc_T65
Condition
medical conditions
NCT02735577_exc_T66
Condition
that would l or medical
NCT02735577_exc_T67
Condition
interfere
NCT02735577_exc_T68
Procedure
MRI scanning
NCT02735577_exc_T69
Scope
Neurological or medical conditions
NCT02735577_exc_T70
Condition
stroke
NCT02735577_exc_T71
Condition
seizure
NCT02735577_exc_T72
Condition
brain tumor
NCT02735577_exc_T73
Condition
brain infection
NCT02735577_exc_T74
Condition
traumatic brain injury
NCT02735577_exc_T75
Condition
multiple sclerosis
NCT02735577_exc_T76
Condition
dementia
NCT02735577_exc_T77
Device
metal device in body
NCT02735577_exc_T78
Condition
pregnancy
NCT02735577_exc_T79
Condition
claustrophobia
NCT02735577_exc_T80
Condition
color blindness
NCT02735577_exc_T81
Condition
hearing impairment
NCT02735577_exc_T82
Qualifier
severe
NCT02735577_exc_T83
Measurement
weight
NCT02735577_exc_T84
Value
>300 lbs.
NCT02735577_exc_T85
Condition
wheelchair-bound
NCT02735577_exc_T86
Drug
alcohol
NCT02735577_exc_T87
Drug
metronidazole
NCT02735577_exc_T88
Drug
isoniazid
NCT02735577_exc_T89
Drug
paraldehyde
NCT02735577_exc_T90
Drug
phenytoin
NCT02735577_exc_T91
Drug
warfarin
NCT02735577_exc_T92
Drug
theophylline
NCT02735577_exc_T93
Temporal
Currently
NCT02735577_exc_T94
Scope
alcohol, metronidazole, isoniazid, paraldehyde, phenytoin, warfarin, or theophylline
NCT02735577_exc_T95
Qualifier
Significant
NCT02735577_exc_T96
Condition
alcohol withdrawal
NCT02735577_exc_T97
Measurement
CIWA
NCT02735577_exc_T98
Value
>8
NCT02735577_exc_T99
Temporal
at screening
NCT02735577_exc_T100
Measurement
blood alcohol level
NCT02735577_exc_T101
Value
zero