History of any malignancy or other severe diseases
Female patients who are pregnant or breastfeeding before or during the three-year follow-up
Poor compliance or refusal to participate.

NCT03513874_exc_T1
Condition
malignancy
NCT03513874_exc_T2
Condition
severe diseases
NCT03513874_exc_T4
Observation
Poor compliance
NCT03513874_exc_T5
Observation
refusal to participate