Known hypersensitivity to tetracycline, doxycycline or azithromycin
Administration of doxycycline, azithromycin, chloramphenicol, rifampicin, or tetracycline during the preceding 7 days
Pregnancy or breast-feeding
Patients with myasthenia gravis or systemic lupus erythematosus
Patients with an established infection (diagnostic test required) e.g. acute malaria, dengue, leptospirosis, typhoid, Japanese encephalitis etc.
Current TB or TB treatment in = 6 months (contain active antibiotics against Orientia spp.)
Current HAART use for HIV, long term use of immunosuppressants (e.g. steroids, chemotherapy, TNF-inhibitors and related agents)
Patients with severe disease whom the clinical team feel their condition necessitates the need for additional scrub typhus treatment beyond the allocated antibiotic treatment assigned at randomization (e.g. IV chloramphenicol and/or PO/NG rifampicin)

NCT03083197_exc_T1
Condition
hypersensitivity
NCT03083197_exc_T2
Drug
tetracycline
NCT03083197_exc_T3
Drug
doxycycline
NCT03083197_exc_T4
Drug
azithromycin
NCT03083197_exc_T5
Scope
tetracycline, doxycycline or azithromycin
NCT03083197_exc_T6
Drug
doxycycline
NCT03083197_exc_T7
Drug
azithromycin
NCT03083197_exc_T8
Drug
chloramphenicol
NCT03083197_exc_T9
Drug
rifampicin
NCT03083197_exc_T10
Drug
tetracycline
NCT03083197_exc_T11
Temporal
during the preceding 7 days
NCT03083197_exc_T12
Scope
doxycycline, azithromycin, chloramphenicol, rifampicin, or tetracycline
NCT03083197_exc_T13
Condition
Pregnancy
NCT03083197_exc_T14
Observation
breast-feeding
NCT03083197_exc_T15
Condition
myasthenia gravis
NCT03083197_exc_T16
Condition
systemic lupus erythematosus
NCT03083197_exc_T17
Condition
infection
NCT03083197_exc_T18
Procedure
diagnostic test
NCT03083197_exc_T19
Condition
acute malaria
NCT03083197_exc_T20
Condition
dengue
NCT03083197_exc_T21
Condition
leptospirosis
NCT03083197_exc_T22
Condition
typhoid
NCT03083197_exc_T23
Condition
Japanese encephalitis
NCT03083197_exc_T24
Scope
acute malaria, dengue, leptospirosis, typhoid, Japanese encephalitis
NCT03083197_exc_T25
Condition
TB
NCT03083197_exc_T26
Procedure
TB treatment
NCT03083197_exc_T27
Temporal
in = 6 months
NCT03083197_exc_T28
Procedure
HAART
NCT03083197_exc_T29
Condition
HIV
NCT03083197_exc_T30
Multiplier
long term use
NCT03083197_exc_T31
Drug
immunosuppressants
NCT03083197_exc_T32
Drug
steroids
NCT03083197_exc_T33
Drug
chemotherapy
NCT03083197_exc_T34
Drug
TNF-inhibitors
NCT03083197_exc_T35
Scope
steroids, chemotherapy, TNF-inhibitors