Unwillingness or inability to comply with the procedures described in this protocol
Planned cardiac surgery or planned major non-cardiac surgery within the study period.
Stroke or coronary revascularization in the past 6 months.
Clinically significant pulmonary disease.
Untreated hyperthyroidism, or hypothyroidism.
A diagnosis of cancer (other than superficial squamous or basal cell skin cancer) in the past 3 years or current treatment for the active cancer.
Female of child-bearing potential who do not use adequate contraception and women who are pregnant or breast-feeding
Any clinically significant abnormality identified at the screening visit, physical examination, laboratory tests, or electrocardiogram which, in the judgment of the Investigator, would preclude safe completion of the study.
LV ejection fraction < 50%.
Significant renal disease manifested by serum creatinine > 2.5 mg/dL
Hepatic disease or biliary tract obstruction, or significant hepatic enzyme elevation (ALT or AST > 3 times upper limit of normal).
History of intolerance to ARB or amlodipine.
Hypertrophic or restrictive cardiomyopathy.
Moderate or severe valvular disease.
Constrictive pericarditis
Atrial fibrillation with a heart rate > 120/min.
Sitting systolic BP < 100 mmHg

NCT02973035_exc_T2
Temporal
within the study period
NCT02973035_exc_T3
Procedure
surgery
NCT02973035_exc_T4
Qualifier
cardiac
NCT02973035_exc_T5
Negation
non
NCT02973035_exc_T6
Qualifier
major
NCT02973035_exc_T7
Mood
planned
NCT02973035_exc_T8
Procedure
cardiac surgery
NCT02973035_exc_T9
Mood
Planned
NCT02973035_exc_T10
Scope
Planned cardiac surgery or planned major non-cardiac surgery
NCT02973035_exc_T11
Reference_point
study period
NCT02973035_exc_T12
Procedure
coronary revascularization
NCT02973035_exc_T13
Procedure
roke o vascularization i
NCT02973035_exc_T14
Temporal
in the past 6 months
NCT02973035_exc_T15
Scope
Stroke or coronary revascularization
NCT02973035_exc_T16
Condition
pulmonary disease
NCT02973035_exc_T17
Qualifier
nically si nificant pu
NCT02973035_exc_T18
Condition
hyperthyroidism
NCT02973035_exc_T19
Condition
hypothyroidism
NCT02973035_exc_T20
Qualifier
Untreated
NCT02973035_exc_T21
Scope
hyperthyroidism, or hypothyroidism
NCT02973035_exc_T22
Condition
cancer
NCT02973035_exc_T23
Negation
other than
NCT02973035_exc_T24
Condition
ficial squamous or b cancer) in
NCT02973035_exc_T25
Condition
basal cell skin cancer
NCT02973035_exc_T26
Scope
superficial squamous or basal cell skin cancer
NCT02973035_exc_T27
Temporal
in the past 3 years
NCT02973035_exc_T28
Procedure
treatment
NCT02973035_exc_T29
Condition
cancer
NCT02973035_exc_T30
Qualifier
active
NCT02973035_exc_T31
Scope
cancer (other than superficial squamous or basal cell skin cancer)
NCT02973035_exc_T34
Measurement
LV ejection fraction
NCT02973035_exc_T35
Value
< 50%
NCT02973035_exc_T36
Condition
renal disease
NCT02973035_exc_T37
Qualifier
Significant
NCT02973035_exc_T38
Measurement
serum creatinine
NCT02973035_exc_T39
Value
> 2.5 mg/dL
NCT02973035_exc_T40
Condition
Hepatic disease
NCT02973035_exc_T41
Condition
biliary tract obstruction
NCT02973035_exc_T42
Condition
hepatic enzyme elevation
NCT02973035_exc_T43
Qualifier
significant
NCT02973035_exc_T44
Measurement
ALT
NCT02973035_exc_T45
Measurement
AST
NCT02973035_exc_T46
Value
> 3 times upper limit of normal
NCT02973035_exc_T47
Scope
ALT or AST
NCT02973035_exc_T48
Condition
intolerance
NCT02973035_exc_T49
Drug
ARB
NCT02973035_exc_T50
Drug
amlodipine
NCT02973035_exc_T51
Scope
ARB or amlodipine
NCT02973035_exc_T52
Condition
restrictive cardiomyopathy
NCT02973035_exc_T53
Condition
 or restric hy.
Moderate o
NCT02973035_exc_T54
Condition
valvular disease
NCT02973035_exc_T55
Qualifier
severe
NCT02973035_exc_T56
Qualifier
Moderate
NCT02973035_exc_T57
Scope
Moderate or severe
NCT02973035_exc_T58
Condition
Constrictive pericarditis
NCT02973035_exc_T59
Condition
Atrial fibrillation
NCT02973035_exc_T60
Measurement
heart rate
NCT02973035_exc_T61
Value
> 120/min
NCT02973035_exc_T62
Condition
systolic BP
NCT02973035_exc_T63
Qualifier
Sitting
NCT02973035_exc_T64
Value
< 100 mmHg