Age = 15 years old
Hospitalization with acute undifferentiated fever (temperature > 37.5 C, tympanic) =14 days or patients admitted to hospital with a history of fever = 14 days who subsequently develop fever within 24 hours of admission
Clinically suspected scrub typhus: defined as acute undifferentiated fever with no clear focus of infection and negative malaria blood smear and/or negative malaria RDT. Patients may have one, none, or a combination of other clinical findings such as eschar, rash, lymphadenopathy, headache, myalgia, cough, nausea and abdominal discomfort.
A positive scrub typhus RDT (Scrub Typhus IgM RDT, InBios International, Seattle, WA, USA) and/or positive PCR-based detection of O. tsutsugamushi DNA from the admission blood sample
Written informed consent and/or, written informed assent as required
Able to take oral medication

NCT03083197_inc_T1
Person
Age
NCT03083197_inc_T3
Procedure
Hospitalization
NCT03083197_inc_T4
Condition
acute undifferentiated fever
NCT03083197_inc_T5
Measurement
temperature
NCT03083197_inc_T6
Value
> 37.5 C
NCT03083197_inc_T7
Condition
tympanic
NCT03083197_inc_T8
Scope
temperature > 37.5 C, tympanic
NCT03083197_inc_T9
Multiplier
=14 days
NCT03083197_inc_T10
Observation
history
NCT03083197_inc_T11
Condition
fever
NCT03083197_inc_T12
Multiplier
= 14 days
NCT03083197_inc_T13
Condition
fever
NCT03083197_inc_T14
Temporal
within 24 hours of admission
NCT03083197_inc_T15
Procedure
admitted to hospital
NCT03083197_inc_T16
Reference_point
admission
NCT03083197_inc_T2
Value
= 15 years old
NCT03083197_inc_T17
Scope
history of fever = 14 days who subsequently develop fever within 24 hours of admission
NCT03083197_inc_T18
Condition
scrub typhus
NCT03083197_inc_T19
Condition
acute undifferentiated fever
NCT03083197_inc_T20
Condition
focus of infection
NCT03083197_inc_T21
Negation
no clear
NCT03083197_inc_T22
Value
negative
NCT03083197_inc_T23
Measurement
malaria blood smear
NCT03083197_inc_T24
Value
negative
NCT03083197_inc_T25
Measurement
malaria RDT
NCT03083197_inc_T26
Multiplier
one
NCT03083197_inc_T27
Multiplier
none
NCT03083197_inc_T28
Multiplier
a combination of
NCT03083197_inc_T29
Scope
one, none, or a combination of
NCT03083197_inc_T30
Condition
eschar
NCT03083197_inc_T31
Condition
rash
NCT03083197_inc_T32
Condition
lymphadenopathy
NCT03083197_inc_T33
Condition
headache
NCT03083197_inc_T34
Condition
myalgia
NCT03083197_inc_T35
Condition
cough
NCT03083197_inc_T36
Condition
nausea
NCT03083197_inc_T37
Condition
abdominal discomfort
NCT03083197_inc_T38
Scope
eschar, rash, lymphadenopathy, headache, myalgia, cough, nausea and abdominal discomfort
NCT03083197_inc_T39
Scope
one, none, or a combination of other clinical findings such as eschar, rash, lymphadenopathy, headache, myalgia, cough, nausea and abdominal discomfort
NCT03083197_inc_T40
Scope
acute undifferentiated fever with no clear focus of infection and negative malaria blood smear and/or negative malaria RDT
NCT03083197_inc_T41
Measurement
scrub typhus RDT
NCT03083197_inc_T42
Value
positive
NCT03083197_inc_T43
Procedure
Scrub Typhus IgM RDT
NCT03083197_inc_T44
Value
positive
NCT03083197_inc_T45
Procedure
PCR
NCT03083197_inc_T46
Qualifier
O. tsutsugamushi DNA
NCT03083197_inc_T47
Qualifier
admission blood sample
NCT03083197_inc_T48
Observation
Written informed consent
NCT03083197_inc_T49
Observation
written informed assent
NCT03083197_inc_T50
Observation
Able to take oral medication
NCT03083197_inc_T51
Drug
oral medication