1. Taking a tetracycline within 6 months or history of adverse reaction to minocycline or another tetracycline. 
2. Enhanced risk from lumbar puncture, including documented or suspected cerebral mass lesion predisposing to brain herniation or bleeding diathesis. 
3. Pregnancy or expectation of pregnancy during the study. 
4. Active opportunistic infection or active neurological disease that might confound evaluation. 
5. ADC Stage > 1. 
6. Hemoglobin < 10 Gms/dL. 
7. BUN or creatine above the normal limits. 
8. Taking other drugs known to reduce the metabolism of minocycline and thus increase the probability of toxicity.       
    

NCT01064752_exc_T1
Drug
tetracycline
NCT01064752_exc_T2
Temporal
within 6 months
NCT01064752_exc_T3
Observation
history
NCT01064752_exc_T4
Condition
adverse reaction
NCT01064752_exc_T5
Drug
minocycline
NCT01064752_exc_T6
Drug
tetracycline
NCT01064752_exc_T7
Scope
minocycline or another tetracycline
NCT01064752_exc_T8
Procedure
lumbar puncture
NCT01064752_exc_T9
Mood
Enhanced risk
NCT01064752_exc_T10
Condition
cerebral mass lesion
NCT01064752_exc_T11
Qualifier
predisposing to brain herniation or bleeding diathesis
NCT01064752_exc_T12
Mood
predisposing to
NCT01064752_exc_T13
Condition
brain herniation
NCT01064752_exc_T14
Condition
bleeding diathesis
NCT01064752_exc_T15
Scope
brain herniation or bleeding diathesis
NCT01064752_exc_T16
Mood
documented
NCT01064752_exc_T17
Mood
suspected
NCT01064752_exc_T18
Scope
documented or suspected
NCT01064752_exc_T19
Scope
documented or suspected cerebral mass lesion predisposing to brain herniation or bleeding diathesis
NCT01064752_exc_T20
Scope
Enhanced risk from lumbar puncture
NCT01064752_exc_T21
Condition
Pregnancy
NCT01064752_exc_T22
Mood
expectation
NCT01064752_exc_T23
Condition
pregnancy
NCT01064752_exc_T24
Temporal
during the study
NCT01064752_exc_T25
Scope
Pregnancy or expectation of pregnancy
NCT01064752_exc_T26
Condition
opportunistic infection
NCT01064752_exc_T27
Qualifier
opportunistic
NCT01064752_exc_T28
Temporal
Active
NCT01064752_exc_T29
Condition
neurological disease
NCT01064752_exc_T30
Temporal
active
NCT01064752_exc_T31
Measurement
ADC Stage
NCT01064752_exc_T32
Value
> 1
NCT01064752_exc_T33
Measurement
Hemoglobin
NCT01064752_exc_T34
Value
< 10 Gms/dL
NCT01064752_exc_T35
Measurement
BUN
NCT01064752_exc_T36
Measurement
creatine
NCT01064752_exc_T37
Value
above the normal limits
NCT01064752_exc_T38
Scope
BUN or creatine
NCT01064752_exc_T39
Drug
minocycline