Congestive heart failure or coronary artery disease
Blood pressure averaging > 159/99 mmHg
Serum creatinine > 1.5 mg/dL
Diabetes mellitus or other systemic illness
Left ventricular hypertrophy by echocardiography or ECG
Pregnancy
Hypersensitivity to spironolactone, chlorthalidone, amlodipine, human recombinant insulin or Definity
Any history of substance abuse (other than tobacco)
History of gouty arthritis
Patients with right-to-left, bi-directional, or transient right-to-left cardiac shunts
Hypersensitivity to perflutren, blood, blood products or albumin

NCT02102243_exc_T1
Condition
Congestive heart failure
NCT02102243_exc_T2
Condition
coronary artery disease
NCT02102243_exc_T3
Measurement
Blood pressure
NCT02102243_exc_T4
Value
> 159/99 mmHg
NCT02102243_exc_T5
Measurement
Serum creatinine
NCT02102243_exc_T6
Value
> 1.5 mg/dL
NCT02102243_exc_T7
Condition
Diabetes mellitus
NCT02102243_exc_T8
Condition
systemic illness
NCT02102243_exc_T9
Condition
Left ventricular hypertrophy
NCT02102243_exc_T10
Procedure
echocardiography
NCT02102243_exc_T11
Procedure
ECG
NCT02102243_exc_T12
Scope
echocardiography or ECG
NCT02102243_exc_T13
Condition
Pregnancy
NCT02102243_exc_T14
Condition
Hypersensitivity
NCT02102243_exc_T15
Drug
spironolactone
NCT02102243_exc_T16
Drug
chlorthalidone
NCT02102243_exc_T17
Drug
amlodipine
NCT02102243_exc_T18
Drug
human recombinant insulin
NCT02102243_exc_T19
Scope
spironolactone, chlorthalidone, amlodipine, human recombinant insulin
NCT02102243_exc_T20
Condition
substance abuse
NCT02102243_exc_T21
Observation
tobacco
NCT02102243_exc_T22
Negation
other
NCT02102243_exc_T23
Condition
gouty arthritis
NCT02102243_exc_T24
Qualifier
right-to-left,
NCT02102243_exc_T25
Qualifier
bi-directional
NCT02102243_exc_T26
Qualifier
transient
NCT02102243_exc_T27
Qualifier
right-to-left
NCT02102243_exc_T28
Condition
cardiac shunts
NCT02102243_exc_T29
Scope
transient right-to-left
NCT02102243_exc_T30
Scope
right-to-left, bi-directional, or transient right-to-left
NCT02102243_exc_T31
Condition
Hypersensitivity
NCT02102243_exc_T32
Drug
perflutren
NCT02102243_exc_T33
Procedure
blood
NCT02102243_exc_T34
Procedure
blood products
NCT02102243_exc_T35
Drug
albumin
NCT02102243_exc_T36
Scope
perflutren, blood, blood products or albumin