Active opioid dependence
Acute or chronic pain requiring opioid treatment
Acute liver injury (liver aminotransferase concentrations >5 times the upper limit of normal)
Health condition considered unsafe for inclusion (at discretion of PI and/or attending physician)
Lack of capacity or willingness to consent
Currently prescribed pharmacotherapy for alcohol dependence (not including treatment of acute alcohol withdrawal syndrome)
Previous significant adverse reaction to naltrexone or diluent
Pregnant, nursing, or not using effective methods of birth control
Prisoners (as defined by Office of Human Research Protection) at the time of enrollment ARE NOT ELIGIBLE for study entry. However, subjects who become prisoners after being enrolled will be included and not be withdrawn from the study. Patients on parole or probation are eligible for enrollment.

NCT02445339_exc_T1
Qualifier
Active
NCT02445339_exc_T2
Condition
opioid dependence
NCT02445339_exc_T3
Qualifier
Acute
NCT02445339_exc_T4
Qualifier
chronic
NCT02445339_exc_T5
Condition
pain
NCT02445339_exc_T6
Scope
Acute or chronic
NCT02445339_exc_T7
Procedure
opioid treatment
NCT02445339_exc_T8
Condition
Acute liver injury
NCT02445339_exc_T9
Measurement
liver aminotransferase concentrations
NCT02445339_exc_T10
Value
>5 times the upper limit of normal
NCT02445339_exc_T11
Scope
liver aminotransferase concentrations >5 times the upper limit of normal
NCT02445339_exc_T12
Condition
Health condition
NCT02445339_exc_T13
Qualifier
considered unsafe for inclusion
NCT02445339_exc_T15
Observation
willingness to consent
NCT02445339_exc_T16
Negation
Lack of
NCT02445339_exc_T17
Observation
city or onsent
Cur
NCT02445339_exc_T18
Scope
capacity or willingness to consent
NCT02445339_exc_T19
Condition
alcohol dependence
NCT02445339_exc_T20
Procedure
pharmacotherapy
NCT02445339_exc_T21
Temporal
Currently
NCT02445339_exc_T22
Negation
not including
NCT02445339_exc_T23
Procedure
treatment
NCT02445339_exc_T24
Condition
acute alcohol withdrawal syndrome
NCT02445339_exc_T25
Temporal
Previous
NCT02445339_exc_T26
Qualifier
significant
NCT02445339_exc_T27
Condition
adverse reaction
NCT02445339_exc_T28
Drug
naltrexone
NCT02445339_exc_T29
Drug
diluent
NCT02445339_exc_T30
Scope
naltrexone or diluent
NCT02445339_exc_T31
Condition
Pregnant
NCT02445339_exc_T32
Condition
nursing
NCT02445339_exc_T33
Negation
not
NCT02445339_exc_T34
Procedure
birth control
NCT02445339_exc_T35
Qualifier
effective methods
NCT02445339_exc_T36
Person
Prisoners
NCT02445339_exc_T37
Qualifier
Office of Human Research Protection
NCT02445339_exc_T38
Temporal
at the time of enrollment
NCT02445339_exc_T39
Reference_point
the time of enrollment