eGFR <45
Type 2 diabetes (HbA1c>6.5) or type 1 diabetes
Any tobacco or nicotine product use in the past year
Low vitamin B12 Levels (< 300 pg/mL)
Self-reported severe difficulty or inability to walk 400m or climb 10 steps (from Q 2 and 19 on PAT-D)
Self-reported difficulty or inability to perform basic ADL functions (from Q 10, 13, 14, 16 on PAT-D)
Excessive alcohol use (>14 drinks/week)
Cancer requiring treatment in past year (except skin)
Dementia - diagnosed and/or MoCA score <18
Parkinson's or other neurological disease
Chronic liver disease or cirrhosis
End stage renal disease or on dialysis
Rheumatic conditions (Rheumatoid arthritis, lupus, and any other autoimmune disease the -PI deems them to be ineligible for)
Thyroid problems the PI deems them to be ineligible for
Gout
Involved in another interventional study
Hemoglobin <8 or diagnosed with anemia
Recent unintentional weight change (+/- 10 lbs. in the last 12 months)
BMI <18.5
Likely to not follow the protocol
PI deems unfit to participate
Already taking Metformin or any other drug intended to treat diabetes

NCT02986659_exc_T1
Measurement
eGFR
NCT02986659_exc_T2
Value
<45
NCT02986659_exc_T3
Condition
Type 2 diabetes
NCT02986659_exc_T4
Measurement
HbA1c
NCT02986659_exc_T5
Value
>6.5
NCT02986659_exc_T6
Condition
type 1 diabetes
NCT02986659_exc_T7
Observation
nicotine product use
NCT02986659_exc_T8
Observation
tobacco
NCT02986659_exc_T9
Scope
tobacco or nicotine product use
NCT02986659_exc_T10
Temporal
past year
NCT02986659_exc_T11
Measurement
vitamin B12 Levels
NCT02986659_exc_T12
Value
< 300 pg/mL
NCT02986659_exc_T15
Observation
alcohol use
NCT02986659_exc_T16
Multiplier
>14 drinks/week
NCT02986659_exc_T17
Condition
Cancer
NCT02986659_exc_T18
Procedure
treatment
NCT02986659_exc_T19
Temporal
past year
NCT02986659_exc_T20
Condition
Dementia
NCT02986659_exc_T21
Measurement
MoCA score
NCT02986659_exc_T22
Value
<18
NCT02986659_exc_T23
Condition
Parkinson's
NCT02986659_exc_T24
Condition
neurological disease
NCT02986659_exc_T25
Condition
Chronic liver disease
NCT02986659_exc_T26
Condition
cirrhosis
NCT02986659_exc_T27
Condition
End stage renal disease
NCT02986659_exc_T28
Procedure
dialysis
NCT02986659_exc_T29
Condition
Rheumatic conditions
NCT02986659_exc_T30
Condition
Rheumatoid arthritis
NCT02986659_exc_T31
Condition
lupus
NCT02986659_exc_T32
Condition
autoimmune disease
NCT02986659_exc_T33
Scope
Rheumatoid arthritis, lupus, and any other autoimmune disease
NCT02986659_exc_T34
Condition
Thyroid problems
NCT02986659_exc_T35
Condition
Gout
NCT02986659_exc_T37
Measurement
Hemoglobin
NCT02986659_exc_T38
Value
<8
NCT02986659_exc_T39
Condition
anemia
NCT02986659_exc_T40
Measurement
weight
NCT02986659_exc_T41
Value
+/- 10 lbs.
NCT02986659_exc_T42
Temporal
last 12 months
NCT02986659_exc_T43
Measurement
BMI
NCT02986659_exc_T44
Value
<18.5
NCT02986659_exc_T47
Drug
Metformin
NCT02986659_exc_T48
Drug
drug
NCT02986659_exc_T49
Qualifier
diabetes