Central + mixed apneas > 25% of the total apnea-hypopnea index (AHI)
Any anatomical finding that would compromise the performance of upper airway stimulation, such as the presence of complete concentric collapse of the soft palate
Any condition or procedure that has compromised neurological control of the upper airway
Patients who are unable or do not have the necessary assistance to operate the patient remote
Patients who are pregnant or plan to become pregnant
Patients who will require magnetic resonance imaging (MRI)
Patients with an implantable device that may be susceptible to unintended interaction with the Inspire system.
Body Mass Index (BMI) of > 32
Any chronic medical illness or condition that contraindicates a surgical procedure under general anesthesia, as judged by the clinical study Investigator
Has a terminal illness with life expectancy < 12 months
Active psychiatric disease (psychotic illness, major depression, or acute anxiety attacks) which prevents subject compliance with the requirements of the investigational study testing
Any other reason the investigator deems subject is unfit for participation in the study

NCT02413970_exc_T1
Condition
mixed apneas
NCT02413970_exc_T2
Condition
Central apneas
NCT02413970_exc_T3
Value
> 25%
NCT02413970_exc_T4
Measurement
total apnea-hypopnea index
NCT02413970_exc_T5
Measurement
AHI
NCT02413970_exc_T6
Scope
Central + mixed apneas
NCT02413970_exc_T11
Procedure
magnetic resonance imaging
NCT02413970_exc_T12
Procedure
MRI
NCT02413970_exc_T14
Measurement
Body Mass Index
NCT02413970_exc_T15
Measurement
BMI
NCT02413970_exc_T16
Value
> 32
NCT02413970_exc_T17
Condition
contraindicates
NCT02413970_exc_T18
Procedure
surgical procedure
NCT02413970_exc_T19
Procedure
general anesthesia
NCT02413970_exc_T20
Observation
life expectancy
NCT02413970_exc_T21
Value
< 12 months
NCT02413970_exc_T22
Condition
psychiatric disease
NCT02413970_exc_T23
Condition
psychotic illness
NCT02413970_exc_T24
Condition
major depression
NCT02413970_exc_T25
Condition
acute anxiety attacks
NCT02413970_exc_T26
Scope
psychotic illness, major depression, or acute anxiety attacks