Hemoglobin concentration under 6.5 mmol/l screening 
HBA1c more than 108 mmol/l 
Non-compliant with blood-letting 
Clinically infected ulcer 
Patient planned for or has had a revascularization procedure in the affected leg within the last 8 weeks 
The ulcer have been treated with growth factors in the last 8 weeks 
History of deep venous insufficiency, chronic venous leg ulcer or stasis dermatitis 
Breast-feeding women or fertile women not agreeing to use an effective method of contraception 
Participation in another clinical ulcer-healing study within the last 4 weeks 
Patient has previously been randomized in this study 
Judgement by the investigator that the patient is not able to participate in the study       
    

NCT02958072_exc_T1
Measurement
Hemoglobin concentration
NCT02958072_exc_T2
Value
under 6.5 mmol/l
NCT02958072_exc_T3
Measurement
HBA1c
NCT02958072_exc_T4
Value
more than 108 mmol/l
NCT02958072_exc_T5
Condition
Non-compliant
NCT02958072_exc_T6
Procedure
blood-letting
NCT02958072_exc_T8
Condition
infected ulcer
NCT02958072_exc_T9
Procedure
revascularization procedure
NCT02958072_exc_T10
Reference_point
affected leg
NCT02958072_exc_T11
Temporal
within the last 8 weeks
NCT02958072_exc_T12
Observation
planned
NCT02958072_exc_T13
Observation
has had
NCT02958072_exc_T14
Scope
planned for or has had
NCT02958072_exc_T15
Condition
ulcer
NCT02958072_exc_T16
Procedure
treated
NCT02958072_exc_T17
Drug
growth factors
NCT02958072_exc_T18
Temporal
in the last 8 weeks
NCT02958072_exc_T19
Condition
deep venous insufficiency
NCT02958072_exc_T20
Condition
chronic venous leg ulcer
NCT02958072_exc_T21
Condition
stasis dermatitis
NCT02958072_exc_T22
Scope
deep venous insufficiency, chronic venous leg ulcer or stasis dermatitis
NCT02958072_exc_T23
Observation
History
NCT02958072_exc_T24
Condition
Breast-feeding
NCT02958072_exc_T25
Person
women
NCT02958072_exc_T26
Condition
fertile
NCT02958072_exc_T27
Person
women
NCT02958072_exc_T28
Observation
agreeing to use an effective method of contraception
NCT02958072_exc_T29
Negation
not