Males and females with confirmed disease: Fabry (by GLA enzymes and/or DNA testing) naïve and on ERT, Mitochondrial diseases (electron transport chain and/or DNA testing) or connective tissue diseases (clinical criteria and/or DNA testing when available) 
Consenting adults (18 years and older) who agrees and consents to skin biopsy and QSART procedure 

NCT02985710_inc_T1
Person
Males
NCT02985710_inc_T2
Person
females
NCT02985710_inc_T4
Qualifier
Fabry naïve
NCT02985710_inc_T5
Procedure
ERT
NCT02985710_inc_T6
Procedure
GLA enzymes
NCT02985710_inc_T7
Procedure
DNA testing
NCT02985710_inc_T8
Scope
GLA enzymes and/or DNA testing
NCT02985710_inc_T9
Condition
confirmed disease
NCT02985710_inc_T11
Condition
Mitochondrial diseases
NCT02985710_inc_T12
Procedure
electron transport chain
NCT02985710_inc_T13
Procedure
DNA testing
NCT02985710_inc_T14
Scope
electron transport chain and/or DNA testing
NCT02985710_inc_T15
Condition
connective tissue diseases
NCT02985710_inc_T16
Procedure
DNA testing
NCT02985710_inc_T17
Observation
clinical criteria
NCT02985710_inc_T18
Scope
clinical criteria and/or DNA testing
NCT02985710_inc_T20
Scope
Fabry (by GLA enzymes and/or DNA testing) naïve and on ERT
NCT02985710_inc_T21
Scope
Fabry (by GLA enzymes and/or DNA testing) naïve and on ERT, Mitochondrial diseases (electron transport chain and/or DNA testing) or connective tissue diseases (clinical criteria and/or DNA testing when available)