1. Male and female subjects must be 18 years of age or older and ambulatory. 
2. Females of child-bearing potential (FOCP) must have a negative serum beta human chorionic gonadotropin (HCG) pregnancy test. 
3. A documented history of severe Symptomatic Orthostatic Hypotension (SOH) that, in the judgment of the treating physician, has required treatment with midodrine HCl , and has been at a stable dose for at least 3 months. 
4. The subject has manifested at least 1 of the following symptoms while standing or had a medical history of 1 of the following when not treated for orthostatic hypotension (OH): dizziness, lightheadedness, feeling faint, or feeling like they might black out. 

NCT01518946_inc_T1
Person
Male
NCT01518946_inc_T2
Person
female
NCT01518946_inc_T3
Value
18 years or older
NCT01518946_inc_T4
Person
age
NCT01518946_inc_T5
Visit
ambulatory
NCT01518946_inc_T6
Person
Females
NCT01518946_inc_T7
Condition
child-bearing potential
NCT01518946_inc_T8
Measurement
serum beta human chorionic gonadotropin (HCG) pregnancy test
NCT01518946_inc_T9
Value
negative
NCT01518946_inc_T10
Scope
Females of child-bearing potential
NCT01518946_inc_T11
Condition
Symptomatic Orthostatic Hypotension (SOH)
NCT01518946_inc_T12
Qualifier
severe
NCT01518946_inc_T13
Drug
midodrine HCl
NCT01518946_inc_T14
Qualifier
stable dose
NCT01518946_inc_T15
Temporal
for at least 3 months
NCT01518946_inc_T16
Multiplier
at least 1
NCT01518946_inc_T17
Condition
dizziness
NCT01518946_inc_T18
Condition
lightheadedness
NCT01518946_inc_T19
Condition
feeling faint
NCT01518946_inc_T20
Condition
feeling like they might black out
NCT01518946_inc_T21
Condition
orthostatic hypotension (OH)
NCT01518946_inc_T22
Procedure
treated
NCT01518946_inc_T23
Negation
not
NCT01518946_inc_T24
Multiplier
1
NCT01518946_inc_T25
Scope
dizziness, lightheadedness, feeling faint, or feeling like they might black out