History of sensitivity to study medications or any of their excipients
RA cohort: Previous intolerance to MTX
Current treatment with antiplatelet therapy
Absolute indication for anti-platelet therapy
Need for chronic oral anticoagulant therapy
Severe hepatic impairment (eg, ascites and/or clinical signs of coagulopathy)
Renal failure (eGFR <30 or requiring dialysis)
A known bleeding diathesis, hemostatic or coagulation disorder, or prior major bleeding
Prior stroke
Active pathological bleeding
History of intracranial haemorrhage
Life expectancy <12 months based on investigator's judgement
Patients considered to be at risk of bradycardic events (e.g., known sick sinus syndrome or second or third degree atrioventricular [AV)] block) unless already treated with a permanent pacemaker
Anemia (hematocrit < 27%)
Platelet count < 100,000/ml
Concomitant use of strong CYP 3A inhibitors or inducers
History of thrombocytopenia or neutropenia
Pregnant or nursing women, or females with a positive pregnancy test at screening
Females of child bearing potential not using acceptable method of birth control prior to or during study
Concern for inability of the patient to comply with study procedures and/or follow up (eg, alcohol or drug abuse)

NCT02874092_exc_T1
Condition
sensitivity
NCT02874092_exc_T2
Drug
study medications
NCT02874092_exc_T3
Condition
RA
NCT02874092_exc_T4
Condition
intolerance
NCT02874092_exc_T5
Drug
MTX
NCT02874092_exc_T6
Procedure
antiplatelet therapy
NCT02874092_exc_T7
Temporal
Current
NCT02874092_exc_T8
Procedure
anti-platelet therapy
NCT02874092_exc_T9
Mood
Absolute indication for
NCT02874092_exc_T10
Mood
Need for
NCT02874092_exc_T11
Procedure
chronic oral anticoagulant therapy
NCT02874092_exc_T12
Condition
Severe hepatic impairment
NCT02874092_exc_T13
Condition
ascites
NCT02874092_exc_T14
Condition
coagulopathy
NCT02874092_exc_T15
Mood
clinical signs of
NCT02874092_exc_T16
Scope
ascites and/or clinical signs of coagulopathy
NCT02874092_exc_T17
Condition
Renal failure
NCT02874092_exc_T18
Measurement
eGFR
NCT02874092_exc_T19
Value
<30
NCT02874092_exc_T20
Mood
requiring
NCT02874092_exc_T21
Procedure
dialysis
NCT02874092_exc_T22
Scope
eGFR <30 or requiring dialysis
NCT02874092_exc_T23
Condition
bleeding diathesis
NCT02874092_exc_T24
Condition
coagulation disorder
NCT02874092_exc_T25
Condition
tic or coa r, or pr
NCT02874092_exc_T26
Condition
major bleeding
NCT02874092_exc_T27
Condition
stroke
NCT02874092_exc_T28
Temporal
Active
NCT02874092_exc_T29
Temporal
Prior
NCT02874092_exc_T30
Temporal
prior
NCT02874092_exc_T31
Condition
pathological bleeding
NCT02874092_exc_T32
Condition
intracranial haemorrhage
NCT02874092_exc_T33
Observation
History
NCT02874092_exc_T34
Measurement
Life expectancy
NCT02874092_exc_T35
Value
<12 months
NCT02874092_exc_T37
Condition
bradycardic events
NCT02874092_exc_T38
Mood
at risk of
NCT02874092_exc_T39
Condition
sick sinus syndrome
NCT02874092_exc_T40
Condition
third degree atrioventricular [AV)] block
NCT02874092_exc_T41
Condition
ird de ventricular [AV)] block) unless alr
NCT02874092_exc_T42
Device
permanent pacemaker
NCT02874092_exc_T43
Negation
unless
NCT02874092_exc_T44
Scope
sick sinus syndrome or second or third degree atrioventricular [AV)] block
NCT02874092_exc_T45
Condition
Anemia
NCT02874092_exc_T46
Measurement
hematocrit
NCT02874092_exc_T47
Value
< 27%
NCT02874092_exc_T48
Scope
hematocrit < 27%
NCT02874092_exc_T49
Measurement
Platelet count
NCT02874092_exc_T50
Value
< 100,000/ml
NCT02874092_exc_T51
Drug
strong CYP 3A inhibitors
NCT02874092_exc_T52
Drug
nhibitors or y of thr
NCT02874092_exc_T53
Condition
thrombocytopenia
NCT02874092_exc_T54
Condition
neutropenia
NCT02874092_exc_T55
Observation
History
NCT02874092_exc_T56
Scope
thrombocytopenia or neutropenia
NCT02874092_exc_T57
Condition
Pregnant
NCT02874092_exc_T58
Condition
nursing
NCT02874092_exc_T59
Person
women
NCT02874092_exc_T60
Person
females
NCT02874092_exc_T61
Value
positive
NCT02874092_exc_T62
Measurement
pregnancy test
NCT02874092_exc_T63
Temporal
at screening
NCT02874092_exc_T64
Scope
Pregnant or nursing women
NCT02874092_exc_T65
Scope
females with a positive pregnancy test at screening
NCT02874092_exc_T66
Reference_point
screening
NCT02874092_exc_T67
Person
Females
NCT02874092_exc_T68
Condition
child bearing potential
NCT02874092_exc_T69
Qualifier
acceptable
NCT02874092_exc_T70
Observation
method of birth control
NCT02874092_exc_T71
Temporal
 study
 inabi
NCT02874092_exc_T72
Temporal
during study
NCT02874092_exc_T73
Scope
prior to or during study
NCT02874092_exc_T74
Negation
not
NCT02874092_exc_T76
Observation
tient to y procedures and/or follow up (
NCT02874092_exc_T75
Observation
tient to y procedures a hol or dr
NCT02874092_exc_T77
Condition
se)
NCT02874092_exc_T78
Condition
drug abuse
NCT02874092_exc_T79
Scope
alcohol or drug abuse
NCT02874092_exc_T80
Scope
inability of the patient to comply with study procedures and/or follow up
NCT02874092_exc_T81
Mood
Concern for