Patients who had history of systemic antibiotic usage over the previous 4 months 
Patients who were pregnant 
Patients who had received non-surgical periodontal treatment within the past 6 months 
Patients who had received surgical periodontal treatment within the past 12 months 
Patients who were smokers 
Patients with a history of stroke or an acute cardiovascular event over the previous 12 months.       
    

NCT02208739_exc_T1
Drug
systemic antibiotic
NCT02208739_exc_T2
Temporal
over the previous 4 months
NCT02208739_exc_T3
Observation
history
NCT02208739_exc_T4
Condition
pregnant
NCT02208739_exc_T5
Procedure
non-surgical periodontal treatment
NCT02208739_exc_T6
Temporal
within the past 6 months
NCT02208739_exc_T7
Procedure
surgical periodontal treatment
NCT02208739_exc_T8
Temporal
within the past 12 months
NCT02208739_exc_T9
Condition
smokers
NCT02208739_exc_T10
Condition
stroke
NCT02208739_exc_T11
Procedure
acute cardiovascular event
NCT02208739_exc_T12
Temporal
over the previous 12 months