The difference in blood pressure between the selected arm versus non-selected arm is = 20 mmHg for siSBP and = 10 mmHg for siDBP at Visit 1 (screening).
Blood pressure taken at screening and randomization is = 180 mmHg for siSBP or = 110 mmHg for siDBP.
Diagnosed with secondary hypertension or suspected of secondary hypertension [e.g., renovascular disease, adrenal medullary and cortical hyperfunction, coarctation of the aorta, hyperaldosteronism, unilateral or bilateral renal artery stenosis, Cushing's syndrome, pheochromocytoma, polycystic kidney disease, etc.]
Patients with symptomatic orthostatic hypertension (the difference in the blood pressures between measured at supine position and measured at standing position is = 20 mmHg for siSBP and = 10 mmHg for siDBP)
Diagnosis of type 1 diabetes mellitus (DM) or uncontrolled DM (patients on insulin therapy or with HbA1c > 9%)
Patients with severe cardiac conditions: heart failure (NYHA Class 3 or 4), history of ischemic cardiac disease (unstable angina, myocardial infarction), peripheral vascular diseases, percutaneous transluminal angioplasty or coronary artery bypass graft within recent 6 months.
Patients with clinically significant ventricular tachycardia, atrial fibrillation, atrial flutter or other clinically significant arrhythmia at the discretion of the investigator
Patients with hypertrophic occlusive myocardiopathy, severe occlusive coronary artery disease, aortic stenosis, hemodynamically significant aortic valve or mitral valve stenosis
History of cardiogenic shock
Presence of severe cerebrovascular disorders (diagnosis of stroke, cerebral infarction or cerebral hemorrhage within recent 6 months)
History or current evidence of wasting, autoimmune (such as rheumatoid arthritis and systemic lupus erythematosus) or connective tissue diseases
Known diagnosis of moderate or malignant retinopathy (including retinal hemorrhage, visual disturbance and retinal microaneurysm within 6 months)
Patients with surgical or medical intestinal diseases or having received surgeries that could interfere with drug absorption distribution, metabolism and elimination
History of malignancy including leukemia and lymphoma within recent 5 years except for localized basal cell carcinoma of the skin)
Patients with any inflammatory diseases requiring chronic anti-inflammatory therapy
Renal failure on dialysis
AST or ALT >2 x upper limit of normal (ULN)
Serum creatinine > 1.5 x ULN
Serum potassium < 3.5 mmol/L or >5.5 mmol/L
Needs for co-administration of non-study antihypertensive agents or contraindicated medications during the study
History of hypersensitivity to ARBs or dihydropyridines
History of angioedema to treatment with ACE inhibitors or ARBs
Pregnant or lactating women and female volunteers of childbearing potential (except for women who are surgically sterile) who are not willing to use an adequate method of contraception (oral contraceptives, intrauterine device, condom, etc.) during the study. Women of childbearing potential who are not surgically sterile will be allowed to participate in the study only if they have negative pregnancy test at Visit 1 (screening) and should continue to use medically acceptable method of contraception (basic body temperature method and rhythm method will not be allowed). Women with no menses for = 12 months will be considered as postmenopausal state and method of contraception using hormonal contraception such as oral contraceptive should be initiated from or prior to the screening.
History of drug or alcohol abuse within recent 1 year
Patients having received any other investigational product within recent 12 weeks
Conditions which render a subject ineligible for the study at the discretion of the investigator

NCT03231982_exc_T1
Measurement
difference in blood pressure
NCT03231982_exc_T2
Qualifier
selected arm versus non-selected arm
NCT03231982_exc_T3
Value
= 20 mmHg
NCT03231982_exc_T4
Value
= 10 mmHg
NCT03231982_exc_T5
Measurement
siDBP
NCT03231982_exc_T6
Measurement
siSBP
NCT03231982_exc_T7
Temporal
at Visit 1
NCT03231982_exc_T8
Measurement
Blood pressure
NCT03231982_exc_T9
Temporal
at screening
NCT03231982_exc_T10
Temporal
t andomization
NCT03231982_exc_T11
Value
= 180 mmHg
NCT03231982_exc_T12
Value
= 110 mmHg
NCT03231982_exc_T13
Measurement
siDBP
NCT03231982_exc_T14
Measurement
siSBP
NCT03231982_exc_T15
Scope
= 180 mmHg for siSBP or = 110 mmHg for siDBP
NCT03231982_exc_T16
Condition
hypertension
NCT03231982_exc_T17
Qualifier
secondary
NCT03231982_exc_T18
Mood
suspected
NCT03231982_exc_T19
Qualifier
secondary
NCT03231982_exc_T20
Condition
hypertension
NCT03231982_exc_T21
Condition
renovascular disease
NCT03231982_exc_T22
Condition
renal medullary a perfunction,
NCT03231982_exc_T23
Condition
cortical hyperfunction
NCT03231982_exc_T24
Condition
coarctation of the aorta
NCT03231982_exc_T25
Condition
hyperaldosteronism
NCT03231982_exc_T26
Qualifier
unilateral
NCT03231982_exc_T27
Qualifier
bilateral
NCT03231982_exc_T28
Condition
renal artery stenosis
NCT03231982_exc_T29
Scope
unilateral or bilateral
NCT03231982_exc_T30
Condition
Cushing's syndrome
NCT03231982_exc_T31
Condition
pheochromocytoma
NCT03231982_exc_T32
Condition
polycystic kidney disease
NCT03231982_exc_T33
Scope
renovascular disease, adrenal medullary and cortical hyperfunction, coarctation of the aorta, hyperaldosteronism, unilateral or bilateral renal artery stenosis, Cushing's syndrome, pheochromocytoma, polycystic kidney disease
NCT03231982_exc_T34
Scope
secondary hypertension or suspected of secondary hypertension
NCT03231982_exc_T35
Condition
orthostatic hypertension
NCT03231982_exc_T36
Qualifier
symptomatic
NCT03231982_exc_T37
Measurement
difference in the blood pressures
NCT03231982_exc_T38
Qualifier
measured at supine position and measured at standing position
NCT03231982_exc_T39
Value
= 20 mmHg
NCT03231982_exc_T40
Value
= 10 mmHg
NCT03231982_exc_T41
Measurement
siDBP
NCT03231982_exc_T42
Measurement
siSBP
NCT03231982_exc_T43
Scope
difference in the blood pressures between measured at supine position and measured at standing position is = 20 mmHg for siSBP and = 10 mmHg for siDBP
NCT03231982_exc_T44
Scope
symptomatic orthostatic hypertension
NCT03231982_exc_T45
Condition
type 1 diabetes mellitus (DM)
NCT03231982_exc_T46
Qualifier
uncontrolled
NCT03231982_exc_T47
Condition
DM
NCT03231982_exc_T48
Procedure
insulin therapy
NCT03231982_exc_T49
Measurement
HbA1c
NCT03231982_exc_T50
Value
> 9%
NCT03231982_exc_T51
Scope
insulin therapy or with HbA1c > 9%
NCT03231982_exc_T52
Scope
type 1 diabetes mellitus (DM) or uncontrolled DM
NCT03231982_exc_T53
Qualifier
severe
NCT03231982_exc_T54
Condition
cardiac conditions
NCT03231982_exc_T55
Condition
heart failure
NCT03231982_exc_T56
Measurement
NYHA
NCT03231982_exc_T57
Value
Class 3 or 4
NCT03231982_exc_T58
Observation
history
NCT03231982_exc_T59
Condition
ischemic cardiac disease
NCT03231982_exc_T60
Condition
unstable angina
NCT03231982_exc_T61
Condition
myocardial infarction
NCT03231982_exc_T62
Condition
peripheral vascular diseases
NCT03231982_exc_T63
Procedure
percutaneous transluminal angioplasty
NCT03231982_exc_T64
Procedure
coronary artery bypass graft
NCT03231982_exc_T65
Temporal
within recent 6 months
NCT03231982_exc_T66
Scope
percutaneous transluminal angioplasty or coronary artery bypass graft
NCT03231982_exc_T67
Scope
unstable angina, myocardial infarction), peripheral vascular diseases, percutaneous transluminal angioplasty or coronary artery bypass graft within recent 6 months
NCT03231982_exc_T68
Scope
heart failure (NYHA Class 3 or 4), history of ischemic cardiac disease (unstable angina, myocardial infarction), peripheral vascular diseases, percutaneous transluminal angioplasty or coronary artery bypass graft within recent 6 months
NCT03231982_exc_T69
Qualifier
clinically significant
NCT03231982_exc_T70
Condition
ventricular tachycardia
NCT03231982_exc_T71
Condition
atrial fibrillation
NCT03231982_exc_T72
Condition
atrial flutter
NCT03231982_exc_T73
Qualifier
clinically significant
NCT03231982_exc_T74
Condition
arrhythmia
NCT03231982_exc_T75
Scope
ventricular tachycardia, atrial fibrillation, atrial flutter
NCT03231982_exc_T76
Condition
hypertrophic occlusive myocardiopathy
NCT03231982_exc_T77
Qualifier
severe
NCT03231982_exc_T78
Condition
occlusive coronary artery disease
NCT03231982_exc_T79
Condition
aortic stenosis
NCT03231982_exc_T80
Qualifier
hemodynamically significant
NCT03231982_exc_T85
Condition
mitral valve stenosis
NCT03231982_exc_T87
Condition
cardiogenic shock
NCT03231982_exc_T88
Observation
History
NCT03231982_exc_T82
Qualifier
severe
NCT03231982_exc_T81
Condition
valve or mit s
Histor
NCT03231982_exc_T83
Scope
aortic valve or mitral valve stenosis
NCT03231982_exc_T84
Condition
cerebrovascular disorders
NCT03231982_exc_T86
Condition
stroke
NCT03231982_exc_T89
Condition
cerebral infarction
NCT03231982_exc_T90
Condition
cerebral hemorrhage
NCT03231982_exc_T91
Temporal
within recent 6 months
NCT03231982_exc_T92
Scope
stroke, cerebral infarction or cerebral hemorrhage
NCT03231982_exc_T93
Scope
severe cerebrovascular disorders
NCT03231982_exc_T94
Observation
History
NCT03231982_exc_T95
Temporal
current
NCT03231982_exc_T96
Observation
wasting
NCT03231982_exc_T97
Condition
 (such a nown dia
NCT03231982_exc_T98
Condition
rheumatoid arthritis
NCT03231982_exc_T99
Condition
systemic lupus erythematosus
NCT03231982_exc_T100
Condition
connective tissue diseases
NCT03231982_exc_T102
Scope
rheumatoid arthritis and systemic lupus erythematosus
NCT03231982_exc_T101
Scope
History or current
NCT03231982_exc_T103
Scope
wasting, autoimmune (such as rheumatoid arthritis and systemic lupus erythematosus) or connective tissue diseases
NCT03231982_exc_T104
Qualifier
malignant
NCT03231982_exc_T105
Qualifier
moderate
NCT03231982_exc_T106
Condition
retinopathy
NCT03231982_exc_T107
Condition
retinal hemorrhage
NCT03231982_exc_T108
Condition
visual disturbance
NCT03231982_exc_T109
Condition
retinal microaneurysm
NCT03231982_exc_T110
Temporal
within 6 months
NCT03231982_exc_T111
Scope
moderate or malignant
NCT03231982_exc_T112
Scope
retinal hemorrhage, visual disturbance and retinal microaneurysm
NCT03231982_exc_T113
Condition
intestinal diseases
NCT03231982_exc_T114
Qualifier
surgical
NCT03231982_exc_T115
Qualifier
medical
NCT03231982_exc_T116
Scope
surgical or medical
NCT03231982_exc_T117
Procedure
surgeries
NCT03231982_exc_T118
Qualifier
could interfere with drug absorption distribution
NCT03231982_exc_T119
Qualifier
ere with drug absorption nd elimina
NCT03231982_exc_T120
Qualifier
ere with drug absorption History of
NCT03231982_exc_T121
Scope
could interfere with drug absorption distribution, metabolism and elimination
NCT03231982_exc_T122
Scope
surgical or medical intestinal diseases or having received surgeries
NCT03231982_exc_T123
Condition
malignancy
NCT03231982_exc_T124
Observation
History of
NCT03231982_exc_T125
Condition
leukemia
NCT03231982_exc_T126
Condition
lymphoma
NCT03231982_exc_T127
Temporal
within recent 5 years
NCT03231982_exc_T128
Condition
localized basal cell carcinoma of the skin
NCT03231982_exc_T129
Negation
except for
NCT03231982_exc_T130
Scope
leukemia and lymphoma
NCT03231982_exc_T131
Condition
inflammatory diseases
NCT03231982_exc_T132
Qualifier
chronic
NCT03231982_exc_T133
Procedure
anti-inflammatory therapy
NCT03231982_exc_T134
Drug
anti-inflammatory therapy
NCT03231982_exc_T135
Condition
Renal failure
NCT03231982_exc_T136
Procedure
dialysis
NCT03231982_exc_T137
Measurement
AST
NCT03231982_exc_T138
Measurement
ALT
NCT03231982_exc_T139
Value
>2 x upper limit of normal (ULN)
NCT03231982_exc_T140
Scope
AST or ALT
NCT03231982_exc_T141
Measurement
Serum creatinine
NCT03231982_exc_T142
Value
> 1.5 x ULN
NCT03231982_exc_T143
Measurement
Serum potassium
NCT03231982_exc_T144
Value
< 3.5 mmol/L
NCT03231982_exc_T145
Value
>5.5 mmol/L
NCT03231982_exc_T146
Scope
< 3.5 mmol/L or >5.5 mmol/L
NCT03231982_exc_T147
Temporal
f non-study antih story of hyperse
NCT03231982_exc_T148
Qualifier
non-study
NCT03231982_exc_T149
Drug
antihypertensive agents
NCT03231982_exc_T150
Drug
contraindicated medications
NCT03231982_exc_T151
Condition
hypersensitivity
NCT03231982_exc_T152
Drug
ARBs
NCT03231982_exc_T153
Drug
dihydropyridines
NCT03231982_exc_T154
Scope
ARBs or dihydropyridines
NCT03231982_exc_T155
Condition
angioedema
NCT03231982_exc_T156
Procedure
treatment
NCT03231982_exc_T157
Drug
ACE inhibitors
NCT03231982_exc_T158
Drug
ARBs
NCT03231982_exc_T159
Scope
ACE inhibitors or ARBs
NCT03231982_exc_T160
Observation
History of
NCT03231982_exc_T161
Observation
History of
NCT03231982_exc_T162
Condition
Pregnant
NCT03231982_exc_T163
Condition
lactating
NCT03231982_exc_T164
Person
women
NCT03231982_exc_T165
Person
female
NCT03231982_exc_T166
Observation
childbearing potential
NCT03231982_exc_T167
Scope
Pregnant or lactating women and female volunteers of childbearing potential
NCT03231982_exc_T168
Negation
not
NCT03231982_exc_T169
Mood
willing to
NCT03231982_exc_T170
Procedure
adequate method of contraception
NCT03231982_exc_T172
Observation
History
NCT03231982_exc_T173
Condition
ithi ear
P
NCT03231982_exc_T174
Condition
alcohol abuse
NCT03231982_exc_T175
Temporal
within recent 1 year
NCT03231982_exc_T176
Scope
drug or alcohol abuse
NCT03231982_exc_T177
Drug
other investigational product
NCT03231982_exc_T178
Temporal
within recent 12 weeks