Known pregnancy or breast-feeding. 
Medical illness unrelated to the tumor which in the opinion of the attending physician and principal investigator will preclude administration of the agent. This includes patients with uncontrolled infection, chronic renal insufficiency, myocardial infarction within the past 6 months, unstable angina, cardiac arrhythmias other than chronic atrial fibrillation and chronic active or persistent hepatitis, or New York Heart Association Classification III or IV heart disease.       
    

NCT02106598_exc_T1
Condition
pregnancy
NCT02106598_exc_T2
Condition
breast-feeding
NCT02106598_exc_T3
Condition
Medical illness unrelated to the tumor
NCT02106598_exc_T8
Condition
uncontrolled infection
NCT02106598_exc_T10
Condition
chronic renal insufficiency
NCT02106598_exc_T11
Condition
myocardial infarction
NCT02106598_exc_T12
Temporal
within the past 6 months
NCT02106598_exc_T13
Condition
unstable angina
NCT02106598_exc_T14
Condition
cardiac arrhythmias
NCT02106598_exc_T15
Condition
chronic atrial fibrillation
NCT02106598_exc_T16
Negation
other than
NCT02106598_exc_T18
Condition
persistent hepatitis
NCT02106598_exc_T17
Measurement
New York Heart Association
NCT02106598_exc_T19
Value
Classification III or IV
NCT02106598_exc_T20
Condition
heart disease
NCT02106598_exc_T22
Condition
chronic active hepatitis