Untreated symptomatic brain or leptomeningeal metastatic disease. 
Medical or psychiatric conditions comprising informed consent. 
Any medical condition which in the opinion of the investigator would compromise the ability of the patient to participate in the trial or which would jeopardise compliance with the protocol. 
Radiotherapy within 4 weeks of trial entry. 
Active autoimmune disease that has required systemic treatment in past 2 years 
Chronic usage of steroids or other immunosuppressant medication. 
Previous history of pneumonitis. 
Any evidence of clinical autoimmunity.       
    

NCT02733159_exc_T1
Condition
symptomatic brain metastatic disease
NCT02733159_exc_T2
Condition
symptomatic leptomeningeal metastatic disease
NCT02733159_exc_T3
Qualifier
Untreated
NCT02733159_exc_T4
Condition
psychiatric conditions
NCT02733159_exc_T6
Condition
Medical conditions
NCT02733159_exc_T11
Procedure
Radiotherapy
NCT02733159_exc_T12
Temporal
within 4 weeks of trial entry
NCT02733159_exc_T13
Reference_point
trial entry
NCT02733159_exc_T14
Condition
autoimmune disease
NCT02733159_exc_T15
Temporal
Active
NCT02733159_exc_T16
Procedure
systemic treatment
NCT02733159_exc_T17
Temporal
in past 2 years
NCT02733159_exc_T18
Drug
steroids
NCT02733159_exc_T19
Multiplier
Chronic usage
NCT02733159_exc_T20
Drug
immunosuppressant medication
NCT02733159_exc_T22
Condition
pneumonitis
NCT02733159_exc_T23
Observation
history
NCT02733159_exc_T24
Condition
autoimmunity
NCT02733159_exc_T25
Condition
Any evidence of clinical autoimmunity