Pregnancy and lactation 
Patients with diabetes, Ischemic heart disease (IHD), stroke, malignancy and psychiatric diseases are excluded from study. 
The patients receiving vitamin supplements or who had clinical evidence for an acute illness, renal dysfunction, thyroid dysfunction, chronic inflammatory diseases, inborn errors of homocysteine, cobalamin or folate metabolism, or any other condition known to interfere with homocysteine metabolism will be excluded 
Patients who are already involved in any other trial. 
Patients not willing to fill consent/ assent form are also excluded from study.       
    

NCT02318446_exc_T1
Condition
Pregnancy
NCT02318446_exc_T2
Condition
lactation
NCT02318446_exc_T4
Condition
diabetes
NCT02318446_exc_T5
Condition
Ischemic heart disease (IHD)
NCT02318446_exc_T6
Condition
stroke
NCT02318446_exc_T7
Condition
malignancy
NCT02318446_exc_T8
Condition
psychiatric diseases
NCT02318446_exc_T10
Drug
vitamin supplements
NCT02318446_exc_T11
Condition
clinical evidence for an acute illness
NCT02318446_exc_T12
Condition
acute illness
NCT02318446_exc_T14
Condition
renal dysfunction
NCT02318446_exc_T15
Condition
thyroid dysfunction
NCT02318446_exc_T16
Condition
chronic inflammatory diseases
NCT02318446_exc_T17
Condition
inborn errors of homocysteine metabolism
NCT02318446_exc_T18
Condition
inborn errors of folate metabolism
NCT02318446_exc_T19
Condition
inborn errors of cobalamin metabolism
NCT02318446_exc_T20
Condition
condition known to interfere with homocysteine metabolism