1. Patients with histologically confirmed diagnosis of colorectal cancer presenting with unresectable stage IV (UICC) disease (primary tumor may be present) 
2. Patients who are feasible for treatment with FOLFOX (prior adjuvant or palliative treatment is allowed) 
3. ECOG Performance status ≤ 1 
4. Life expectancy > 3 months 
5. Age ≥18 years 
6. Haematologic function as follows (5% deviation allowed): 
ANC ≥ 1.5 x 109/L 
platelets ≥ 100 x109/L 
hemoglobin ≥ 9 g/dl or 5.59 mmol/l 
7. Adequate liver function as follows (10% deviation allowed) 
serum alanine transaminase (ALT) ≤ 2.5 x ULN (in case of liver metastases < 5 x ULN) 
total bilirubin ≤ 1.5 x ULN (patients with Gilbert's syndrome total bilirubin ≤2.5 x ULN) 
8. Adequate renal function as follows (10% deviation allowed) 
· creatinine ≤ 1.5 x ULN 
9. Signed written informed consent 
10. Women of child-bearing potential must have a negative pregnancy test 

NCT02384850_inc_T11
Condition
colorectal cancer
NCT02384850_inc_T12
Qualifier
unresectable
NCT02384850_inc_T13
Condition
disease
NCT02384850_inc_T15
Qualifier
stage IV (UICC)
NCT02384850_inc_T16
Value
IV
NCT02384850_inc_T17
Procedure
histologically
NCT02384850_inc_T18
Value
confirmed
NCT02384850_inc_T19
Drug
FOLFOX
NCT02384850_inc_T21
Procedure
palliative treatment
NCT02384850_inc_T22
Procedure
adjuvant treatment
NCT02384850_inc_T24
Measurement
ECOG Performance status
NCT02384850_inc_T25
Value
≤ 1
NCT02384850_inc_T26
Observation
Life expectancy
NCT02384850_inc_T27
Value
> 3 months
NCT02384850_inc_T28
Person
Age
NCT02384850_inc_T29
Value
≥18 years
NCT02384850_inc_T31
Measurement
ANC
NCT02384850_inc_T32
Value
≥ 1.5 x 109/L
NCT02384850_inc_T33
Measurement
platelets
NCT02384850_inc_T34
Value
≥ 100 x109/L
NCT02384850_inc_T35
Measurement
hemoglobin
NCT02384850_inc_T36
Value
≥ 9 g/dl
NCT02384850_inc_T37
Value
≥ 5.59 mmol/l
NCT02384850_inc_T38
Scope
≥ 9 g/dl or 5.59 mmol/l
NCT02384850_inc_T39
Measurement
liver function
NCT02384850_inc_T40
Value
Adequate
NCT02384850_inc_T42
Measurement
serum alanine transaminase (ALT)
NCT02384850_inc_T43
Value
≤ 2.5 x ULN
NCT02384850_inc_T44
Condition
liver metastases
NCT02384850_inc_T45
Value
< 5 x ULN
NCT02384850_inc_T46
Measurement
total bilirubin
NCT02384850_inc_T47
Value
≤ 1.5 x ULN
NCT02384850_inc_T48
Condition
Gilbert's syndrome
NCT02384850_inc_T49
Measurement
total bilirubin
NCT02384850_inc_T50
Value
≤2.5 x ULN
NCT02384850_inc_T51
Measurement
renal function
NCT02384850_inc_T52
Value
Adequate
NCT02384850_inc_T54
Measurement
creatinine
NCT02384850_inc_T55
Value
≤ 1.5 x ULN
NCT02384850_inc_T57
Condition
child-bearing potential
NCT02384850_inc_T58
Person
Women
NCT02384850_inc_T59
Measurement
pregnancy test
NCT02384850_inc_T60
Value
negative
NCT02384850_inc_T61
Scope
Women of child-bearing potential