Use of investigational drugs either within 5 half-lives of enrollment, or within 30 days, or until the expected pharmacodynamic effect has returned to baseline, whichever is longer.
Major surgery in the last 3 months prior to baseline or planned major surgery or cardiac intervention during the study.
Cancer or other significant co-morbidities implying that the patient's condition is unstable.
Comorbidities that can be associated with elevated natriuretic peptide (NP) levels: renal insufficiency, (eGFR < 25 ml/min/1.73 m² calculated according to MDRD formula), recent (less than 3 months) cerebral trauma or recent (less than 3 months) cerebrovascular incident, novel diagnosis or acute exacerbation of COPD within the last 3 months.
Patients who are primarily managed and regularly followed-up by a cardiologist for their HF
Highly frail patients whose estimated lifespan due to comorbidities by the judgement of the investigator is less than 6 months.

NCT02807857_exc_T2
Procedure
Major surgery
NCT02807857_exc_T3
Temporal
last 3 months prior to baseline or planned major surgery or cardiac intervention during the study
NCT02807857_exc_T4
Reference_point
baseline or planned major surgery or cardiac intervention during the stud
NCT02807857_exc_T5
Condition
Cancer
NCT02807857_exc_T6
Condition
co-morbidities
NCT02807857_exc_T7
Condition
Comorbidities
NCT02807857_exc_T8
Measurement
riuretic peptide (N els: r
NCT02807857_exc_T9
Measurement
NP
NCT02807857_exc_T10
Value
elevated
NCT02807857_exc_T11
Condition
renal insufficiency
NCT02807857_exc_T12
Measurement
eGFR
NCT02807857_exc_T13
Value
< 25 ml/min/1.73 m²
NCT02807857_exc_T14
Condition
cerebral trauma
NCT02807857_exc_T15
Temporal
less than 3 months
NCT02807857_exc_T16
Condition
cerebrovascular incident
NCT02807857_exc_T17
Temporal
less than 3 months
NCT02807857_exc_T18
Condition
acute exacerbation of COPD
NCT02807857_exc_T19
Temporal
last 3 months
NCT02807857_exc_T20
Scope
renal insufficiency, (eGFR < 25 ml/min/1.73 m² calculated according to MDRD formula), recent (less than 3 months) cerebral trauma or recent (less than 3 months) cerebrovascular incident, novel diagnosis or acute exacerbation of COPD within the last 3 months
NCT02807857_exc_T22
Observation
lifespan
NCT02807857_exc_T23
Temporal
less than 6 months