Currently pregnant or breastfeeding
Severe pelvic organ prolapse or prolapse to any degree that may prevent retention of the vaginal ring after insertion
Use of oral contraceptive pills, patches, implants or hormonal intrauterine contraception in the month prior to screening
Use of depo medroxyprogesterone within 6 months of screening
Use of medications that interact with contraceptive steroid hormones: anti-epileptic medications, rifampin, rifabutin, fosamprenavir, etc
Medical condition with safety deemed to be category 3 or 4 when using a combined hormonal contraceptive, as determined by the Center for Disease Control Medical Eligibility Criteria: current or past history of breast cancer, severe decompensated cirrhosis, history of deep vein thrombosis or pulmonary embolus, diabetes with nephropathy/retinopathy/neuropathy or other vascular disease diagnosed more than 20 years ago, current symptomatic gallbladder disease, hypertension, ischemic heart disease, known thrombogenic mutations, hepatocellular adenoma, malignant hepatoma, multiple risk factors for atherosclerotic cardiovascular disease, multiple sclerosis with prolonged immobility, history of peripartum cardiomyopathy, cigarette smoking and =35yo, history of complicated solid organ transplant, history of stroke, history of superficial venous thrombosis not associated with catheter, systemic lupus erythematosus with positive antiphospholipid antibodies, valvular heart disease complicated by pulmonary hypertension or atrial fibrillation or bacterial endocarditis, and acute viral hepatitis

NCT03120728_exc_T1
Condition
pregnant
NCT03120728_exc_T2
Temporal
Currently
NCT03120728_exc_T3
Observation
breastfeeding
NCT03120728_exc_T4
Qualifier
Severe
NCT03120728_exc_T5
Condition
pelvic organ prolapse
NCT03120728_exc_T6
Condition
prolapse
NCT03120728_exc_T8
Qualifier
may prevent retention of the vaginal ring after insertion
NCT03120728_exc_T9
Scope
pelvic organ prolapse or prolapse
NCT03120728_exc_T7
Drug
oral contraceptive pills
NCT03120728_exc_T10
Device
patches
NCT03120728_exc_T11
Device
implants
NCT03120728_exc_T12
Procedure
hormonal intrauterine contraception
NCT03120728_exc_T13
Temporal
in the month prior to screening
NCT03120728_exc_T14
Reference_point
screening
NCT03120728_exc_T15
Scope
oral contraceptive pills, patches, implants or hormonal intrauterine contraception
NCT03120728_exc_T16
Drug
depo medroxyprogesterone
NCT03120728_exc_T17
Temporal
within 6 months of screening
NCT03120728_exc_T18
Drug
medications
NCT03120728_exc_T19
Observation
interact with
NCT03120728_exc_T20
Drug
contraceptive steroid hormones
NCT03120728_exc_T21
Drug
anti-epileptic medications
NCT03120728_exc_T22
Drug
rifampin
NCT03120728_exc_T23
Drug
rifabutin
NCT03120728_exc_T24
Drug
fosamprenavir
NCT03120728_exc_T25
Scope
anti-epileptic medications, rifampin, rifabutin, fosamprenavir
NCT03120728_exc_T26
Scope
medications that interact with contraceptive steroid hormones
NCT03120728_exc_T27
Temporal
current
NCT03120728_exc_T28
Temporal
past
NCT03120728_exc_T29
Observation
history
NCT03120728_exc_T30
Condition
breast cancer
NCT03120728_exc_T31
Scope
current or past
NCT03120728_exc_T32
Qualifier
severe
NCT03120728_exc_T33
Qualifier
decompensated
NCT03120728_exc_T34
Condition
cirrhosis
NCT03120728_exc_T35
Observation
history
NCT03120728_exc_T36
Condition
deep vein thrombosis
NCT03120728_exc_T37
Condition
pulmonary embolus
NCT03120728_exc_T38
Condition
diabetes
NCT03120728_exc_T39
Condition
nephropathy
NCT03120728_exc_T40
Condition
retinopathy
NCT03120728_exc_T41
Condition
neuropathy
NCT03120728_exc_T42
Qualifier
other
NCT03120728_exc_T43
Condition
vascular disease
NCT03120728_exc_T44
Temporal
more than 20 years ago
NCT03120728_exc_T45
Scope
nephropathy/retinopathy/neuropathy or other vascular disease
NCT03120728_exc_T46
Temporal
current
NCT03120728_exc_T47
Qualifier
symptomatic
NCT03120728_exc_T48
Condition
gallbladder disease
NCT03120728_exc_T49
Condition
hypertension
NCT03120728_exc_T50
Condition
ischemic heart disease
NCT03120728_exc_T51
Condition
thrombogenic mutations
NCT03120728_exc_T52
Condition
hepatocellular adenoma
NCT03120728_exc_T53
Condition
malignant hepatoma
NCT03120728_exc_T54
Drug
combined hormonal contraceptive
NCT03120728_exc_T55
Multiplier
multiple
NCT03120728_exc_T56
Mood
risk factors
NCT03120728_exc_T57
Condition
atherosclerotic cardiovascular disease
NCT03120728_exc_T58
Condition
multiple sclerosis
NCT03120728_exc_T59
Condition
prolonged immobility
NCT03120728_exc_T60
Observation
history
NCT03120728_exc_T61
Condition
peripartum cardiomyopathy
NCT03120728_exc_T62
Observation
cigarette smoking
NCT03120728_exc_T63
Value
=35yo
NCT03120728_exc_T64
Person
yo
NCT03120728_exc_T65
Scope
cigarette smoking and =35yo
NCT03120728_exc_T66
Procedure
complicated solid organ transplant
NCT03120728_exc_T67
Observation
history
NCT03120728_exc_T68
Observation
history
NCT03120728_exc_T69
Condition
stroke
NCT03120728_exc_T70
Observation
history
NCT03120728_exc_T71
Condition
superficial venous thrombosis
NCT03120728_exc_T72
Qualifier
not associated
NCT03120728_exc_T73
Device
catheter
NCT03120728_exc_T74
Condition
systemic lupus erythematosus
NCT03120728_exc_T75
Value
positive
NCT03120728_exc_T76
Measurement
antiphospholipid antibodies
NCT03120728_exc_T77
Condition
valvular heart disease
NCT03120728_exc_T78
Condition
pulmonary hypertension
NCT03120728_exc_T79
Condition
atrial fibrillation
NCT03120728_exc_T80
Condition
bacterial endocarditis
NCT03120728_exc_T81
Condition
acute viral hepatitis
NCT03120728_exc_T82
Scope
valvular heart disease complicated by pulmonary hypertension or atrial fibrillation or bacterial endocarditis
NCT03120728_exc_T83
Scope
gallbladder disease, hypertension, ischemic heart disease
NCT03120728_exc_T84
Condition
Medical condition
NCT03120728_exc_T86
Value
3 or 4
NCT03120728_exc_T87
Measurement
Center for Disease Control Medical Eligibility Criteria
NCT03120728_exc_T85
Measurement
y deem ory 3 or
NCT03120728_exc_T88
Scope
current or past history of breast cancer, severe decompensated cirrhosis, history of deep vein thrombosis or pulmonary embolus, diabetes with nephropathy/retinopathy/neuropathy or other vascular disease diagnosed more than 20 years ago, current symptomatic gallbladder disease, hypertension, ischemic heart disease, known thrombogenic mutations, hepatocellular adenoma, malignant hepatoma, multiple risk factors for atherosclerotic cardiovascular disease, multiple sclerosis with prolonged immobility, history of peripartum cardiomyopathy, cigarette smoking and =35yo, history of complicated solid organ transplant, history of stroke, history of superficial venous thrombosis not associated with catheter, systemic lupus erythematosus with positive antiphospholipid antibodies, valvular heart disease complicated by pulmonary hypertension or atrial fibrillation or bacterial endocarditis, and acute viral hepatitis
NCT03120728_exc_T89
Scope
Medical condition with safety deemed to be category 3 or 4 when using a combined hormonal contraceptive, as determined by the Center for Disease Control Medical Eligibility Criteria
NCT03120728_exc_T90
Scope
pregnant or breastfeeding