At least 18 years of age at the time of screening
Have stable renal function for one month (30 days) prior to enrollment
Have Chronic HCV infection prior to transplantation with documented HCV viremia = 1,000 IU/ml at screening and either documented HCV Ab positivity or HCV viremia = 1,000 IU/ml at least 6 months prior to enrollment.
Documented genotype 1 HCV infection prior to enrollment and after their transplant in the post-transplantation cohort
HCV disease staging within 12 months prior to enrollment by liver biopsy, transient elastography, or biochemical testing
Be able to give informed consent and comply with study guidelines
Women of childbearing age will be required to have a negative pregnancy test at enrollment and use birth control throughout the duration of treatment.
On the transplant waiting list followed by the University of Maryland's nephrology clinic or the Baltimore VA's nephrology clinic
On chronic hemodialysis not yet on the transplant list and followed in the University's hemodialysis center or in the University's nephrology clinic
Have chronic kidney disease with GFR <50

NCT02902120_inc_T1
Person
age
NCT02902120_inc_T2
Value
At least 18 years
NCT02902120_inc_T3
Measurement
renal function
NCT02902120_inc_T4
Value
stable
NCT02902120_inc_T5
Temporal
one month (30 days) prior to enrollment
NCT02902120_inc_T6
Reference_point
enrollment
NCT02902120_inc_T7
Condition
Chronic HCV infection
NCT02902120_inc_T8
Temporal
prior to transplantation
NCT02902120_inc_T9
Reference_point
transplantation
NCT02902120_inc_T10
Measurement
HCV viremia
NCT02902120_inc_T11
Value
= 1,000 IU/ml
NCT02902120_inc_T12
Measurement
HCV Ab
NCT02902120_inc_T13
Value
positivity
NCT02902120_inc_T14
Measurement
HCV viremia
NCT02902120_inc_T15
Value
= 1,000 IU/ml
NCT02902120_inc_T16
Temporal
at least 6 months prior to enrollment.
NCT02902120_inc_T17
Reference_point
enrollment
NCT02902120_inc_T18
Scope
HCV Ab positivity or HCV viremia = 1,000 IU/ml
NCT02902120_inc_T19
Qualifier
genotype 1
NCT02902120_inc_T20
Condition
HCV infection
NCT02902120_inc_T21
Temporal
prior to enrollment
NCT02902120_inc_T22
Temporal
after their transplant i
NCT02902120_inc_T23
Reference_point
enrollment
NCT02902120_inc_T24
Reference_point
transplant
NCT02902120_inc_T25
Procedure
disease staging
NCT02902120_inc_T26
Qualifier
HCV
NCT02902120_inc_T27
Temporal
within 12 months prior to enrollment
NCT02902120_inc_T28
Reference_point
enrollment
NCT02902120_inc_T29
Procedure
liver biopsy
NCT02902120_inc_T30
Procedure
transient elastography
NCT02902120_inc_T31
Procedure
biochemical testing
NCT02902120_inc_T32
Scope
liver biopsy, transient elastography, or biochemical testing
NCT02902120_inc_T36
Procedure
hemodialysis
NCT02902120_inc_T37
Qualifier
chronic
NCT02902120_inc_T39
Condition
chronic kidney disease
NCT02902120_inc_T40
Measurement
GFR
NCT02902120_inc_T41
Value
<50