Uncontrolled hypertension (defined as average SBP = 160 mmHg [2 readings taken at time of screening]).
End stage renal disease (CrCl < 15 ml/min)
Valvular Heart Disease including those with prosthetic valve, mitral stenosis (moderate to severe) or valve repair.
Excess alcohol intake (males: = 28 units/week, females: = 21 units/week. One unit of alcohol = 8 oz beer, 1 oz hard liquor or 4 oz wine).
Intracranial bleed at any point.
History of "Major Bleeding" at any point (defined as overt bleeding at a critical site including intracranial, intraspinal, intraocular, pericardial, or retroperitoneal; or bleed requiring hospitalization).
Foreshortened life-expectancy or severe comorbidities precluding study follow-up period
Unable to read/understand English
Severe cognitive impairment (defined as score = 5 on the Short Portable Mental Status Questionnaire)

NCT03126214_exc_T1
Condition
hypertension
NCT03126214_exc_T2
Qualifier
Uncontrolled
NCT03126214_exc_T3
Measurement
average SBP
NCT03126214_exc_T4
Value
= 160 mmHg
NCT03126214_exc_T5
Multiplier
2 readings
NCT03126214_exc_T6
Temporal
at time of screening
NCT03126214_exc_T7
Reference_point
screening
NCT03126214_exc_T8
Scope
average SBP = 160 mmHg [2 readings taken at time of screening]
NCT03126214_exc_T9
Scope
Uncontrolled hypertension
NCT03126214_exc_T10
Condition
End stage renal disease
NCT03126214_exc_T11
Measurement
CrCl
NCT03126214_exc_T12
Value
< 15 ml/min
NCT03126214_exc_T13
Scope
CrCl < 15 ml/min
NCT03126214_exc_T14
Condition
Valvular Heart Disease
NCT03126214_exc_T15
Device
prosthetic valve
NCT03126214_exc_T16
Condition
mitral stenosis
NCT03126214_exc_T17
Qualifier
moderate
NCT03126214_exc_T18
Qualifier
severe
NCT03126214_exc_T19
Procedure
valve repair
NCT03126214_exc_T20
Scope
moderate to severe
NCT03126214_exc_T21
Measurement
alcohol intake
NCT03126214_exc_T22
Person
males
NCT03126214_exc_T23
Value
= 28 units/week
NCT03126214_exc_T24
Value
Excess
NCT03126214_exc_T25
Person
females
NCT03126214_exc_T26
Value
= 21 units/week
NCT03126214_exc_T28
Scope
males: = 28 units/week, females: = 21 units/week
NCT03126214_exc_T29
Condition
Intracranial bleed
NCT03126214_exc_T30
Temporal
at any point
NCT03126214_exc_T31
Condition
Major Bleeding
NCT03126214_exc_T32
Temporal
at any point
NCT03126214_exc_T33
Observation
History
NCT03126214_exc_T34
Condition
overt bleeding
NCT03126214_exc_T35
Qualifier
critical site
NCT03126214_exc_T36
Qualifier
intracranial
NCT03126214_exc_T37
Qualifier
intraspinal
NCT03126214_exc_T38
Qualifier
intraocular
NCT03126214_exc_T39
Qualifier
pericardial
NCT03126214_exc_T40
Qualifier
retroperitoneal
NCT03126214_exc_T41
Condition
bleed
NCT03126214_exc_T42
Procedure
hospitalization
NCT03126214_exc_T43
Scope
intracranial, intraspinal, intraocular, pericardial, or retroperitoneal
NCT03126214_exc_T44
Scope
overt bleeding at a critical site including intracranial, intraspinal, intraocular, pericardial, or retroperitoneal; or bleed requiring hospitalization
NCT03126214_exc_T45
Observation
life-expectancy
NCT03126214_exc_T46
Value
Foreshortened
NCT03126214_exc_T47
Condition
severe comorbidities
NCT03126214_exc_T49
Qualifier
Severe
NCT03126214_exc_T50
Condition
cognitive impairment
NCT03126214_exc_T51
Measurement
Short Portable Mental Status Questionnaire
NCT03126214_exc_T52
Value
= 5
NCT03126214_exc_T53
Scope
Severe cognitive impairment
NCT03126214_exc_T54
Scope
= 5 on the Short Portable Mental Status Questionnaire