1. Menstruating females 10-19 years of age 
2. Non-smoker 
3. Physician and patient have agreed to initiate Lysteda 
4. Diagnosis of HMB based on the medical judgment of the principal or site investigator 
5. Subjects must report menstrual periods occurring within 21-60 days from the start of one period to the start of the next menstrual period 
6. Negative pregnancy test 
7. Informed consent obtained and signed 
8. Informed assent obtained and signed 
9. Understanding of study procedures 
10. Ability to comply with study procedures for the entire length of the study 
11. Subjects should be either sexually inactive (abstinent) or agree to use a barrier method with spermicide in the event of sexual activity throughout the study period 

NCT01846507_inc_T1
Condition
Menstruating
NCT01846507_inc_T2
Person
females
NCT01846507_inc_T3
Value
10-19 years
NCT01846507_inc_T4
Person
age
NCT01846507_inc_T5
Condition
Non-smoker
NCT01846507_inc_T6
Drug
Lysteda
NCT01846507_inc_T8
Condition
HMB
NCT01846507_inc_T11
Condition
menstrual periods
NCT01846507_inc_T12
Temporal
within 21-60 days from the start of one period
NCT01846507_inc_T13
Reference_point
the start of one period
NCT01846507_inc_T14
Measurement
pregnancy test
NCT01846507_inc_T15
Value
Negative
NCT01846507_inc_T24
Condition
sexually inactive
NCT01846507_inc_T25
Condition
sexually abstinent
NCT01846507_inc_T26
Device
barrier method with spermicide
NCT01846507_inc_T27
Observation
agree to use