Veteran receiving care within the Veterans Health Administration healthcare system
Age 18 years
Physician diagnosis of chronic heart failure, American Heart Association Stage C-D
LVEF <45%
No change in active cardiac medications for 4 weeks prior to randomization
Ability to provide informed consent
Moderate to severe central or mixed central and obstructive sleep apnea, defined as an apnea-hypopnea index (AHI) 15 events per hour, with a central AHI >5 events/hour

NCT01807897_inc_T1
Person
Veteran
NCT01807897_inc_T2
Visit
Veterans Health Administration healthcare system
NCT01807897_inc_T3
Person
Age
NCT01807897_inc_T4
Value
18 years
NCT01807897_inc_T5
Condition
chronic heart failure
NCT01807897_inc_T6
Measurement
American Heart Association Stage
NCT01807897_inc_T7
Value
C-D
NCT01807897_inc_T8
Measurement
LVEF
NCT01807897_inc_T9
Value
<45%
NCT01807897_inc_T10
Negation
No
NCT01807897_inc_T11
Qualifier
change
NCT01807897_inc_T12
Drug
cardiac medications
NCT01807897_inc_T13
Temporal
for 4 weeks prior to randomization
NCT01807897_inc_T14
Reference_point
randomization
NCT01807897_inc_T16
Condition
obstructive sleep apnea
NCT01807897_inc_T17
Condition
l or mi apnea, defi
NCT01807897_inc_T18
Condition
central and o apnea, defi
NCT01807897_inc_T19
Qualifier
severe
NCT01807897_inc_T20
Qualifier
Moderate
NCT01807897_inc_T21
Measurement
apnea-hypopnea index
NCT01807897_inc_T22
Measurement
AHI
NCT01807897_inc_T23
Value
15 events per hour,
NCT01807897_inc_T24
Measurement
central AHI
NCT01807897_inc_T25
Value
>5 events/hour
NCT01807897_inc_T26
Scope
apnea-hypopnea index (AHI) 15 events per hour, with a central AHI >5 events/hour
NCT01807897_inc_T27
Scope
central or mixed central and obstructive sleep apnea
NCT01807897_inc_T28
Scope
Moderate to severe