1. Signed informed consent 
2. Healthy subjects aged between 18 years and 45 years inclusive 
3. Weighing at least 50 kg 
4. Volunteers must be hospitalized on Days 1-4, 7-9, and 17-20 for pharmacokinetic assessments for each biomarker and TPV/r (Days 7-9 and 17-20) 
5. Volunteers must be willing to complete all study-related activities 
6. Each volunteer must have a valid social security number 
7. Each volunteer must have acceptable medical history, physical examination and laboratory test 

NCT02243553_inc_T10
Person
aged
NCT02243553_inc_T11
Value
between 18 years and 45 years inclusive
NCT02243553_inc_T12
Condition
Healthy
NCT02243553_inc_T13
Measurement
Weighing
NCT02243553_inc_T14
Value
at least 50 kg
NCT02243553_inc_T21
Observation
medical history
NCT02243553_inc_T22
Procedure
physical examination
NCT02243553_inc_T23
Measurement
laboratory test