Patients must have histologic proof of a malignancy suitable for radiation therapy. 
Patients must have received prior external beam radiation therapy to the region proposed for HDR brachytherapy treatment; evaluation of doses previously delivered to spinal cord/cauda equine, pelvis, and other critical structures (bowel, kidneys, rectum) will be taken into consideration. 
If repeat irradiation would exceed any normal tissue constraint set by MSKCC Radiation Oncology Department dose constraint criteria, the patient will potentially be eligible. 
If the total prior radiation dose to the cord or pelvis exceeds 100 Gy BED equivalent, the patient will be potentially eligible, where a total of 100 BED Gy equivalent is determined by the biological equivalent dose (BED) calculation; BED = nd(1 + d/α/β), where n = number of fractions and d = dose per fraction; α/β is the constant for spinal cord late effect and equals 2. [Rades 2005, Nieder 2005, Sahgal 2012] 
KPS ≥ 60 
Age ≥ 18 years old 

NCT01757717_inc_T1
Condition
malignancy
NCT01757717_inc_T2
Qualifier
suitable for radiation therapy
NCT01757717_inc_T3
Procedure
radiation therapy
NCT01757717_inc_T4
Procedure
histologic
NCT01757717_inc_T5
Value
proof
NCT01757717_inc_T7
Procedure
external beam radiation therapy
NCT01757717_inc_T8
Temporal
prior
NCT01757717_inc_T9
Procedure
HDR brachytherapy
NCT01757717_inc_T11
Qualifier
to the region proposed for HDR brachytherapy treatment
NCT01757717_inc_T12
Procedure
repeat irradiation
NCT01757717_inc_T13
Value
exceed any normal tissue constraint
NCT01757717_inc_T14
Measurement
MSKCC Radiation Oncology Department dose constraint criteria
NCT01757717_inc_T16
Measurement
KPS
NCT01757717_inc_T17
Value
≥ 60
NCT01757717_inc_T18
Person
Age
NCT01757717_inc_T19
Value
≥ 18 years old