Lifetime personal history of diagnosis of major depressive disorder according to the DSM-V (American Psychiatric Association, 2013) using the Structured Clinical Interview for DSM-V Axis I Disorders, Research Version, Non-patient Edition (SCID-5-RV for DSM-V; First et al., 2015)
A history of suicidal ideation and behaviour, including self-harm and/or harm to others.
A history of substance abuse and/or dependence.
A positive drug screen for illicit drugs
Substantial alcohol use
Current use of Monoamine Oxidase Inhibitors (MAOIs), including the antibiotic linezolid and the thiazine dye methylthioninium chloride (methylene blue)
Current use of serotonin-precursors (such as L-tryptophan, oxitriptan)
Current use of serotonergic drugs (triptans, certain tricyclic antidepressants, lithium, tramadol, St. John's Wort)
Concomitant use of NSAIDS, ASA, and other anticoagulants.
Current use of Thioridazine
Current use of CYP1A2 Inhibitors
Current use of Triptans (5HT1 Agonists)
Blood pressure greater than 140/90 and/or a pulse rate greater than 90 bpm
Recent history of myocardial infarction, cerebrovascular accident, cardiac arrhythmias, or unstable heart disease.
Evidence of significant physical illness contraindicating the use of levomilnacipran and duloxetine found on the physical exam or in the laboratory data obtained during the first week of the study
Current use of medication that may affect voiding (ie- anticholinergics)
History of obstructive urinary disorders and dysuria, prostatic hypertrophy, prostatitis, and other lower urinary tract obstructive disorders.
History of Stevens-Johnson Syndrome and Erythema multiforme.
Diabetes Type I and II
Fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltase insufficiency.
Hepatic Impairment
Uncontrolled narrow-angle glaucoma
Severe renal impairment
History of seizure disorder
Anatomically narrow ocular angles.
Osteoporosis or major risk for bone fractures.

NCT03249311_exc_T1
Condition
major depressive disorder
NCT03249311_exc_T2
Qualifier
DSM-V
NCT03249311_exc_T3
Procedure
Structured Clinical Interview for DSM-V Axis I Disorders, Research Version, Non-patient Edition
NCT03249311_exc_T4
Condition
suicidal ideation
NCT03249311_exc_T5
Condition
uicidal ehaviour,
NCT03249311_exc_T6
Condition
self-harm
NCT03249311_exc_T7
Condition
harm to others
NCT03249311_exc_T8
Condition
substance abuse
NCT03249311_exc_T9
Condition
bstance a pendence.
NCT03249311_exc_T10
Procedure
drug screen for illicit drugs
NCT03249311_exc_T11
Value
positive
NCT03249311_exc_T12
Condition
Substantial alcohol use
NCT03249311_exc_T13
Drug
Monoamine Oxidase Inhibitors (MAOIs)
NCT03249311_exc_T14
Drug
antibiotic linezolid
NCT03249311_exc_T15
Drug
thiazine dye
NCT03249311_exc_T16
Drug
methylthioninium chloride
NCT03249311_exc_T17
Drug
methylene blue
NCT03249311_exc_T18
Scope
antibiotic linezolid and the thiazine dye methylthioninium chloride (methylene blue)
NCT03249311_exc_T19
Drug
serotonin-precursors
NCT03249311_exc_T20
Drug
L-tryptophan
NCT03249311_exc_T21
Drug
oxitriptan
NCT03249311_exc_T22
Scope
L-tryptophan, oxitriptan
NCT03249311_exc_T23
Drug
serotonergic drugs
NCT03249311_exc_T24
Drug
triptans
NCT03249311_exc_T25
Drug
tricyclic antidepressant
NCT03249311_exc_T26
Drug
lithium
NCT03249311_exc_T27
Drug
tramadol
NCT03249311_exc_T28
Drug
St. John's Wort
NCT03249311_exc_T29
Scope
triptans, certain tricyclic antidepressants, lithium, tramadol, St. John's Wort
NCT03249311_exc_T30
Drug
NSAIDS
NCT03249311_exc_T31
Drug
ASA
NCT03249311_exc_T32
Drug
anticoagulants
NCT03249311_exc_T33
Qualifier
other
NCT03249311_exc_T34
Drug
Thioridazine
NCT03249311_exc_T35
Temporal
Concomitant
NCT03249311_exc_T36
Scope
NSAIDS, ASA, and other anticoagulants
NCT03249311_exc_T37
Drug
CYP1A2 Inhibitors
NCT03249311_exc_T38
Drug
Triptans
NCT03249311_exc_T39
Drug
5HT1 Agonists
NCT03249311_exc_T40
Measurement
Blood pressure
NCT03249311_exc_T41
Value
greater than 140/90
NCT03249311_exc_T42
Measurement
pulse rate
NCT03249311_exc_T43
Value
greater than 90 bpm
NCT03249311_exc_T44
Temporal
Recent
NCT03249311_exc_T45
Observation
history
NCT03249311_exc_T46
Condition
myocardial infarction
NCT03249311_exc_T47
Condition
cerebrovascular accident
NCT03249311_exc_T48
Condition
cardiac arrhythmias
NCT03249311_exc_T49
Condition
unstable heart disease
NCT03249311_exc_T50
Scope
myocardial infarction, cerebrovascular accident, cardiac arrhythmias, or unstable heart disease
NCT03249311_exc_T51
Condition
physical illness
NCT03249311_exc_T52
Condition
contraindicating
NCT03249311_exc_T53
Drug
levomilnacipran
NCT03249311_exc_T54
Drug
duloxetine
NCT03249311_exc_T55
Procedure
physical exam
NCT03249311_exc_T56
Procedure
laboratory
NCT03249311_exc_T57
Temporal
during the first week of the study
NCT03249311_exc_T58
Scope
physical exam or in the laboratory
NCT03249311_exc_T59
Scope
levomilnacipran and duloxetine
NCT03249311_exc_T60
Drug
medication
NCT03249311_exc_T61
Drug
anticholinergics
NCT03249311_exc_T62
Temporal
Current
NCT03249311_exc_T63
Condition
affect voiding
NCT03249311_exc_T64
Condition
obstructive urinary disorders
NCT03249311_exc_T65
Condition
dysuria
NCT03249311_exc_T66
Condition
prostatic hypertrophy
NCT03249311_exc_T67
Condition
prostatitis
NCT03249311_exc_T68
Condition
lower urinary tract obstructive disorders
NCT03249311_exc_T69
Qualifier
other
NCT03249311_exc_T70
Observation
History
NCT03249311_exc_T71
Scope
obstructive urinary disorders and dysuria, prostatic hypertrophy, prostatitis, and other lower urinary tract obstructive disorders
NCT03249311_exc_T72
Condition
Stevens-Johnson Syndrome
NCT03249311_exc_T73
Condition
Erythema multiforme
NCT03249311_exc_T74
Condition
Diabetes Type I
NCT03249311_exc_T75
Condition
d II
Fructose ra
NCT03249311_exc_T76
Condition
Fructose intolerance
NCT03249311_exc_T77
Condition
glucose-galactose malabsorption
NCT03249311_exc_T78
Condition
sucrose-isomaltase insufficiency
NCT03249311_exc_T79
Condition
Hepatic Impairment
NCT03249311_exc_T80
Condition
narrow-angle glaucoma
NCT03249311_exc_T81
Qualifier
Uncontrolled
NCT03249311_exc_T82
Condition
renal impairment
NCT03249311_exc_T83
Qualifier
Severe
NCT03249311_exc_T84
Condition
seizure disorder
NCT03249311_exc_T85
Observation
History
NCT03249311_exc_T86
Condition
Anatomically narrow ocular angles
NCT03249311_exc_T87
Condition
Osteoporosis
NCT03249311_exc_T88
Mood
major risk
NCT03249311_exc_T89
Condition
bone fractures