use of any sedative hypnotics, tranquilizers, anticonvulsants, antihistamines (except non-sedating), benzodiazepines, clonidine or any medication known to affect dopamine at start of baseline period
significant unstable or uncontrolled medical/psychiatric disease
significant history of head trauma/surgery or seizure disorder
radiation exposure exceeding 20mSv in last 12 months
pregnancy
substance abuse/dependence (including alcohol)
have sleep apnea, or are shift workers
on a sodium-restricted diet
has ever taken Xyrem / sodium oxybate / GHB at any time
claustrophobia
metal implants / objects in the body that may interfere with MRI
succinic semialdehyde dehydrogenase deficiency

NCT02637076_exc_T1
Drug
sedative hypnotics
NCT02637076_exc_T2
Drug
tranquilizers
NCT02637076_exc_T3
Drug
anticonvulsants
NCT02637076_exc_T4
Drug
antihistamines
NCT02637076_exc_T5
Qualifier
non-sedating
NCT02637076_exc_T6
Negation
except
NCT02637076_exc_T7
Drug
benzodiazepines
NCT02637076_exc_T8
Drug
clonidine
NCT02637076_exc_T9
Drug
medication known to affect dopamine
NCT02637076_exc_T10
Temporal
at start of baseline period
NCT02637076_exc_T11
Scope
sedative hypnotics, tranquilizers, anticonvulsants, antihistamines (except non-sedating), benzodiazepines, clonidine or any medication known to affect dopamine
NCT02637076_exc_T12
Qualifier
significant
NCT02637076_exc_T13
Qualifier
uncontrolled
NCT02637076_exc_T14
Qualifier
unstable
NCT02637076_exc_T15
Scope
unstable or uncontrolled
NCT02637076_exc_T16
Condition
psychiatric disease
NCT02637076_exc_T17
Condition
edical/ isease
NCT02637076_exc_T18
Scope
medical/psychiatric disease
NCT02637076_exc_T19
Condition
head trauma
NCT02637076_exc_T20
Procedure
ad t rgery o
NCT02637076_exc_T21
Condition
seizure disorder
NCT02637076_exc_T22
Observation
history
NCT02637076_exc_T23
Scope
head trauma/surgery or seizure disorder
NCT02637076_exc_T24
Qualifier
significant
NCT02637076_exc_T25
Condition
radiation exposure
NCT02637076_exc_T26
Value
exceeding 20mSv
NCT02637076_exc_T27
Temporal
in last 12 months
NCT02637076_exc_T28
Condition
pregnancy
NCT02637076_exc_T29
Condition
substance abuse
NCT02637076_exc_T30
Condition
ance abus dence (inc
NCT02637076_exc_T31
Drug
alcohol
NCT02637076_exc_T32
Scope
substance abuse/dependence
NCT02637076_exc_T33
Condition
sleep apnea
NCT02637076_exc_T34
Person
shift workers
NCT02637076_exc_T35
Procedure
sodium-restricted diet
NCT02637076_exc_T36
Drug
Xyrem
NCT02637076_exc_T37
Drug
sodium oxybate
NCT02637076_exc_T38
Drug
GHB
NCT02637076_exc_T39
Temporal
ever
NCT02637076_exc_T40
Scope
Xyrem / sodium oxybate / GHB
NCT02637076_exc_T41
Condition
claustrophobia
NCT02637076_exc_T42
Device
metal implants
NCT02637076_exc_T43
Device
ants  the b
NCT02637076_exc_T44
Mood
may interfere with
NCT02637076_exc_T45
Procedure
MRI
NCT02637076_exc_T46
Scope
metal implants / objects
NCT02637076_exc_T47
Condition
succinic semialdehyde dehydrogenase deficiency