indications to dual antiplatelet therapy other than atrial fibrillation or left atrial appendage occlusion at the time of enrollment or predicted appearance of such indications within the duration of the trial (eg. coronary artery disease)
indications to anticoagulation at the time of enrollment or predicted appearance of such indications within the duration of the trial (eg. pulmonary embolism)
known allergy to clopidogrel or acetylsalicylic acid precluding its administration as specified by the protocol
any known inborn or acquired coagulation disorders
poor tolerance of or technical difficulties with performing transesophageal echocardiography
peridevice leak >5mm on transesophageal echocardiography study preceding enrollment
left atrial thrombus on transesophageal echocardiography study performed after successful left atrial appendage closure but before enrollment
life expectancy of less than 18months
participation in other clinical studies with experimental therapies at the time of enrollment and preceding 3 months
chronic kidney disease stage IV and V
women who are pregnant or breast feeding; women of childbearing potential who do not consent to apply at least to methods of contraception. This criterion does not apply to postmenopausal women

NCT03445949_exc_T1
Procedure
dual antiplatelet therapy
NCT03445949_exc_T2
Negation
other than
NCT03445949_exc_T3
Condition
atrial fibrillation
NCT03445949_exc_T4
Condition
indications
NCT03445949_exc_T5
Condition
left atrial appendage occlusion
NCT03445949_exc_T6
Temporal
at the time of enrollment
NCT03445949_exc_T7
Mood
predicted appearance
NCT03445949_exc_T8
Temporal
within the duration of the trial
NCT03445949_exc_T9
Condition
coronary artery disease
NCT03445949_exc_T10
Scope
predicted appearance of such indications within the duration of the trial
NCT03445949_exc_T11
Scope
atrial fibrillation or left atrial appendage occlusion
NCT03445949_exc_T12
Scope
at the time of enrollment or predicted appearance of such indications within the duration of the trial (eg. coronary artery disease)
NCT03445949_exc_T13
Condition
indications
NCT03445949_exc_T14
Procedure
anticoagulation
NCT03445949_exc_T15
Temporal
at the time of enrollment
NCT03445949_exc_T16
Mood
predicted appearance
NCT03445949_exc_T17
Temporal
within the duration of the trial
NCT03445949_exc_T18
Scope
predicted appearance of such indications within the duration of the trial
NCT03445949_exc_T19
Condition
pulmonary embolism
NCT03445949_exc_T20
Scope
at the time of enrollment or predicted appearance of such indications within the duration of the trial (eg. pulmonary embolism)
NCT03445949_exc_T21
Drug
clopidogrel
NCT03445949_exc_T22
Drug
acetylsalicylic acid
NCT03445949_exc_T23
Condition
allergy
NCT03445949_exc_T25
Scope
clopidogrel or acetylsalicylic acid
NCT03445949_exc_T26
Condition
coagulation disorders
NCT03445949_exc_T27
Condition
poor tolerance
NCT03445949_exc_T28
Observation
technical difficulties
NCT03445949_exc_T29
Procedure
transesophageal echocardiography
NCT03445949_exc_T30
Scope
poor tolerance of or technical difficulties
NCT03445949_exc_T31
Measurement
peridevice leak
NCT03445949_exc_T32
Value
>5mm
NCT03445949_exc_T33
Procedure
transesophageal echocardiography study
NCT03445949_exc_T34
Condition
left atrial thrombus
NCT03445949_exc_T35
Procedure
transesophageal echocardiography
NCT03445949_exc_T36
Procedure
left atrial appendage closure
NCT03445949_exc_T37
Temporal
after successful left atrial appendage closure
NCT03445949_exc_T38
Reference_point
successful left atrial appendage closure
NCT03445949_exc_T39
Qualifier
successful
NCT03445949_exc_T40
Temporal
before enrollment
NCT03445949_exc_T41
Reference_point
enrollment
NCT03445949_exc_T42
Scope
after successful left atrial appendage closure but before enrollment
NCT03445949_exc_T43
Observation
life expectancy
NCT03445949_exc_T44
Value
less than 18months
NCT03445949_exc_T46
Condition
chronic kidney disease
NCT03445949_exc_T47
Qualifier
stage IV
NCT03445949_exc_T48
Qualifier
and V h
NCT03445949_exc_T49
Scope
stage IV and V
NCT03445949_exc_T50
Person
women
NCT03445949_exc_T51
Condition
pregnant
NCT03445949_exc_T52
Observation
breast feeding