Outpatient with primary DSM- IV OCD
Completion of a 14-week open label trial of one the following SRI's: fluoxetine 80 mg/day, paroxetine 60 mg/day, fluvoxamine 300 mg/day, clomipramine 250 mg/day, sertraline 200 mg/day, citalopram 60 mg/day, escitalopram 30 mg/day and demonstrating a non or partial responses to SRI treatment (CGI-I of 3 or 4, Y-BOCS reduction of < 35%)
Stable (8 wks or longer) concurrent medications including benzodiazepines, sedative hypnotics, antipsychotics, and antidepressants.

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Condition
OCD
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Qualifier
primary
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Qualifier
DSM- IV
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Drug
medications
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Qualifier
concurrent
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Qualifier
Stable
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Temporal
8 wks or longer
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Drug
benzodiazepines
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Drug
sedative hypnotics
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Drug
antipsychotics
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Drug
antidepressants
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Scope
benzodiazepines, sedative hypnotics, antipsychotics, and antidepressants
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Multiplier
14-week
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Drug
fluoxetine
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Multiplier
80 mg/day
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Drug
paroxetine
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Multiplier
60 mg/day
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Drug
fluvoxamine
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Multiplier
300 mg/day
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Drug
clomipramine
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Multiplier
250 mg/day
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Drug
sertraline
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Multiplier
200 mg/day
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Drug
citalopram
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Multiplier
60 mg/day
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Drug
escitalopram
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Multiplier
30 mg/day
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Condition
responses to
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Measurement
CGI-I
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Value
3
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Value
4
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Scope
3 or 4
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Measurement
Y-BOCS
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Value
reduction of < 35%
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Scope
CGI-I of 3 or 4, Y-BOCS reduction of < 35%
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Multiplier
one the following
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Scope
fluoxetine 80 mg/day, paroxetine 60 mg/day, fluvoxamine 300 mg/day, clomipramine 250 mg/day, sertraline 200 mg/day, citalopram 60 mg/day, escitalopram 30 mg/day
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Procedure
SRI treatment
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Scope
responses to SRI treatment
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Visit
Outpatient