Histologically or cytologically confirmed adenocarcinoma of the breast with locally advanced or metastatic disease, and a candidate for chemotherapy. 
Human epidermal growth factor receptor 2 (HER2)-positive. 
No prior chemotherapy for their metastatic breast cancer (MBC). 
Measurable disease. 
Age ≥ 18 years. 
For women of childbearing potential and men with partners of childbearing potential, agreement to use a highly effective, non-hormonal form of contraception or 2 effective forms of non-hormonal contraception by the patient and/or partner. Contraception use must continue for the duration of study treatment and for at least 6 months after the last dose of study treatment. Male patients whose partners are pregnant should use condoms for the duration of the study. 

NCT00679341_inc_T1
Qualifier
cytologically confirmed
NCT00679341_inc_T2
Qualifier
Histologically confirmed
NCT00679341_inc_T3
Condition
adenocarcinoma of the breast
NCT00679341_inc_T4
Condition
metastatic disease
NCT00679341_inc_T5
Condition
disease locally advanced
NCT00679341_inc_T6
Condition
candidate for chemotherapy
NCT00679341_inc_T7
Procedure
chemotherapy
NCT00679341_inc_T8
Scope
Histologically or cytologically confirmed
NCT00679341_inc_T9
Scope
adenocarcinoma of the breast with locally advanced or metastatic disease
NCT00679341_inc_T10
Measurement
Human epidermal growth factor receptor 2 (HER2)
NCT00679341_inc_T11
Value
positive
NCT00679341_inc_T12
Procedure
chemotherapy
NCT00679341_inc_T13
Temporal
prior
NCT00679341_inc_T14
Negation
No
NCT00679341_inc_T15
Person
Age
NCT00679341_inc_T16
Value
≥ 18 years
NCT00679341_inc_T17
Condition
Measurable disease
NCT00679341_inc_T18
Condition
metastatic breast cancer (MBC)
NCT00679341_inc_T19
Person
women
NCT00679341_inc_T20
Condition
childbearing potential
NCT00679341_inc_T21
Person
men
NCT00679341_inc_T22
Observation
with partners of childbearing potential
NCT00679341_inc_T23
Scope
women of childbearing potential
NCT00679341_inc_T24
Scope
men with partners of childbearing potential
NCT00679341_inc_T25
Scope
women of childbearing potential and men with partners of childbearing potential
NCT00679341_inc_T26
Qualifier
highly effective
NCT00679341_inc_T27
Qualifier
non-hormonal
NCT00679341_inc_T28
Procedure
contraception
NCT00679341_inc_T29
Multiplier
2
NCT00679341_inc_T30
Procedure
non-hormonal contraception
NCT00679341_inc_T31
Procedure
Contraception
NCT00679341_inc_T32
Temporal
continue for the duration of study treatment
NCT00679341_inc_T33
Reference_point
study treatment
NCT00679341_inc_T34
Temporal
for at least 6 months after the last dose of study treatment
NCT00679341_inc_T35
Reference_point
the last dose of study treatment
NCT00679341_inc_T36
Person
Male
NCT00679341_inc_T37
Observation
partners are pregnant
NCT00679341_inc_T38
Device
condoms
NCT00679341_inc_T39
Temporal
for the duration of the study
NCT00679341_inc_T40
Scope
Male patients whose partners are pregnant