Active proliferative diabetic retinopathy (PDR) in the study eye such as NVE, NVD, vitreous hemorrhage, or neovascular glaucoma.
Uncontrolled hypertension defined as systolic >180 mmHg or > 160 mmHg on 2 consecutive measurements or diastolic > 100 mmHg on optimal medical regimen
Screening HgA1c blood test > 10.0
Focal laser photocoagulation or intravitreal/periocular steroids of any type in the study eye within the last 90 days prior to study enrollment.
A history of intravitreal anti-VEGF injection of any type in the study eye within the last 45 days prior to study enrollment.
History of rhegmatogenous retinal detachment, retinal tear(s), or traction retinal detachments in the study eye.
Epiretinal membrane and/or vitreomacular traction in the study eye as determined by the central reading center.
Previous pars plana vitrectomy in the study eye
Any intraocular surgery in the study eye within the last 90 days prior to study enrollment.
YAG laser treatment in the study eye in last 30 days prior to study enrollment.
High myopia in the study eye, with a spherical equivalent of >8.00D at screening
Other ocular pathologies that in the investigator's opinion would interfere with the subject's vision in the study eye.
Chronic or recurrent uveitis.
Ongoing ocular infection or inflammation in either eye.
A history of cataract surgery complications/vitreous loss in the study eye.
Congenital eye malformations in the study eye.
A history of penetrating ocular trauma in the study eye.
Mentally handicapped.
Pregnant female, as determined for women less than 60 years old by a positive urine pregnancy test during the screening window.
Nursing female.
Currently participating in any other clinical research study.
Contraindication to the study medication.

NCT02348918_exc_T1
Condition
Active proliferative diabetic retinopathy (PDR)
NCT02348918_exc_T2
Qualifier
in the study eye
NCT02348918_exc_T3
Condition
NVE
NCT02348918_exc_T4
Condition
NVD
NCT02348918_exc_T5
Condition
vitreous hemorrhage
NCT02348918_exc_T6
Condition
neovascular glaucoma
NCT02348918_exc_T7
Scope
NVE, NVD, vitreous hemorrhage, or neovascular glaucoma
NCT02348918_exc_T8
Condition
Uncontrolled hypertension
NCT02348918_exc_T9
Measurement
systolic
NCT02348918_exc_T10
Value
>180 mmHg
NCT02348918_exc_T11
Value
> 160 mmHg
NCT02348918_exc_T12
Multiplier
on 2 consecutive measurements
NCT02348918_exc_T13
Scope
>180 mmHg or > 160 mmHg on 2 consecutive measurements
NCT02348918_exc_T14
Measurement
diastolic
NCT02348918_exc_T15
Value
> 100 mmHg
NCT02348918_exc_T16
Procedure
optimal medical regimen
NCT02348918_exc_T17
Qualifier
on optimal medical regimen
NCT02348918_exc_T18
Scope
systolic >180 mmHg or > 160 mmHg on 2 consecutive measurements or diastolic > 100 mmHg on optimal medical regimen
NCT02348918_exc_T19
Temporal
Screening
NCT02348918_exc_T20
Measurement
HgA1c blood test
NCT02348918_exc_T21
Value
> 10.0
NCT02348918_exc_T22
Procedure
Focal laser photocoagulation
NCT02348918_exc_T23
Drug
intravitreal/periocular steroids
NCT02348918_exc_T24
Qualifier
in the study eye
NCT02348918_exc_T25
Temporal
within the last 90 days prior to study enrollment
NCT02348918_exc_T26
Reference_point
study enrollment
NCT02348918_exc_T27
Scope
Focal laser photocoagulation or intravitreal/periocular steroids
NCT02348918_exc_T28
Observation
history of
NCT02348918_exc_T29
Qualifier
intravitreal
NCT02348918_exc_T30
Procedure
anti-VEGF injection
NCT02348918_exc_T31
Qualifier
in the study eye
NCT02348918_exc_T32
Temporal
within the last 45 days prior to study enrollment
NCT02348918_exc_T33
Reference_point
study enrollment
NCT02348918_exc_T34
Condition
rhegmatogenous retinal detachment
NCT02348918_exc_T35
Observation
History of
NCT02348918_exc_T36
Condition
retinal tear(s)
NCT02348918_exc_T37
Condition
traction retinal detachments
NCT02348918_exc_T38
Qualifier
in the study eye
NCT02348918_exc_T39
Scope
rhegmatogenous retinal detachment, retinal tear(s), or traction retinal detachments
NCT02348918_exc_T40
Condition
Epiretinal membrane traction
NCT02348918_exc_T41
Condition
vitreomacular traction
NCT02348918_exc_T42
Qualifier
in the study eye
NCT02348918_exc_T44
Scope
Epiretinal membrane and/or vitreomacular traction
NCT02348918_exc_T45
Temporal
Previous
NCT02348918_exc_T46
Procedure
pars plana vitrectomy
NCT02348918_exc_T47
Qualifier
in the study eye
NCT02348918_exc_T48
Procedure
intraocular surgery
NCT02348918_exc_T49
Qualifier
in the study eye
NCT02348918_exc_T50
Temporal
within the last 90 days prior to study enrollment
NCT02348918_exc_T51
Reference_point
study enrollment
NCT02348918_exc_T52
Procedure
YAG laser treatment
NCT02348918_exc_T53
Qualifier
in the study eye
NCT02348918_exc_T54
Temporal
in last 30 days prior to study enrollment
NCT02348918_exc_T55
Reference_point
study enrollment
NCT02348918_exc_T56
Condition
High myopia
NCT02348918_exc_T57
Qualifier
in the study eye
NCT02348918_exc_T58
Measurement
spherical equivalent
NCT02348918_exc_T59
Value
>8.00D
NCT02348918_exc_T60
Temporal
at screening
NCT02348918_exc_T61
Qualifier
Other
NCT02348918_exc_T62
Condition
ocular pathologies
NCT02348918_exc_T63
Observation
would interfere with the subject's vision in the study eye
NCT02348918_exc_T65
Multiplier
Chronic
NCT02348918_exc_T66
Multiplier
recurrent
NCT02348918_exc_T67
Condition
uveitis
NCT02348918_exc_T68
Scope
Chronic or recurrent
NCT02348918_exc_T69
Temporal
Ongoing
NCT02348918_exc_T70
Condition
ocular infection
NCT02348918_exc_T71
Condition
ocular inflammation
NCT02348918_exc_T72
Qualifier
in either eye
NCT02348918_exc_T73
Scope
ocular infection or inflammation
NCT02348918_exc_T74
Observation
history of
NCT02348918_exc_T75
Procedure
cataract surgery
NCT02348918_exc_T76
Condition
cataract surgery complications
NCT02348918_exc_T77
Condition
vitreous loss
NCT02348918_exc_T78
Qualifier
in the study eye
NCT02348918_exc_T79
Scope
cataract surgery complications/vitreous loss
NCT02348918_exc_T80
Condition
Congenital eye malformations
NCT02348918_exc_T81
Qualifier
in the study eye
NCT02348918_exc_T82
Observation
history of
NCT02348918_exc_T83
Condition
penetrating ocular trauma
NCT02348918_exc_T84
Qualifier
in the study eye
NCT02348918_exc_T85
Condition
Mentally handicapped
NCT02348918_exc_T86
Condition
Pregnant
NCT02348918_exc_T87
Person
female
NCT02348918_exc_T88
Person
women
NCT02348918_exc_T89
Value
less than 60 years
NCT02348918_exc_T90
Person
old
NCT02348918_exc_T91
Value
positive
NCT02348918_exc_T92
Measurement
urine pregnancy test
NCT02348918_exc_T93
Temporal
during the screening window
NCT02348918_exc_T94
Observation
Nursing
NCT02348918_exc_T95
Person
female
NCT02348918_exc_T97
Condition
Contraindication
NCT02348918_exc_T98
Drug
study medication