Male or female = 2 years of age;
Have sickle cell disease (confirmed by Hb electrophoresis or more specific tests) or other conditions with iron overload from repeated blood transfusions (see exclusion criteria for exceptions);
Baseline LIC >7 mg/g dw (measured by MRI);
Patients who have received no less than 20 transfusions of RBCs;
Patients who have received at least 1 transfusion per year in the last 2 years and who are expected to have a continuing requirement (based on Investigator's judgement) during the duration of the trial

NCT02041299_inc_T1
Person
Male
NCT02041299_inc_T2
Person
female
NCT02041299_inc_T3
Value
= 2 years
NCT02041299_inc_T4
Person
age
NCT02041299_inc_T5
Condition
sickle cell disease
NCT02041299_inc_T6
Procedure
Hb electrophoresis
NCT02041299_inc_T7
Procedure
more specific tests
NCT02041299_inc_T8
Scope
Hb electrophoresis or more specific tests
NCT02041299_inc_T10
Condition
other conditions with iron overload
NCT02041299_inc_T9
Multiplier
repeated
NCT02041299_inc_T11
Procedure
blood transfusions
NCT02041299_inc_T12
Measurement
Baseline LIC
NCT02041299_inc_T13
Value
>7 mg/g
NCT02041299_inc_T14
Procedure
MRI
NCT02041299_inc_T15
Multiplier
no less than 20
NCT02041299_inc_T16
Procedure
transfusions of RBCs
NCT02041299_inc_T17
Multiplier
east 1 tra year in
NCT02041299_inc_T18
Temporal
in the last 2 years
NCT02041299_inc_T19
Procedure
transfusion
NCT02041299_inc_T20
Condition
expected to have a continuing requirement
NCT02041299_inc_T21
Temporal
during the duration of the trial