Established pre-existing diabetes (including unrecognised diabetes defined as a fasting plasma glucose = 7.0mmol/L and/ or HbA1c = 48mmol/mol); Contraindications to metformin therapy (creatinine = 130µmol/L/ alanine transaminase = 2.0 x upper limit normal/ previous intolerance to metformin)
Planned continued antenatal care/ delivery at centre not included in trial
Planned fast for cultural/ religious reasons e.g. Ramadan

NCT02394158_exc_T1
Condition
diabetes
NCT02394158_exc_T2
Measurement
fasting plasma glucose
NCT02394158_exc_T3
Value
= 7.0mmol/L
NCT02394158_exc_T4
Measurement
HbA1c
NCT02394158_exc_T5
Value
= 48mmol/mol)
NCT02394158_exc_T6
Condition
Contraindications
NCT02394158_exc_T7
Drug
metformin
NCT02394158_exc_T8
Measurement
creatinine
NCT02394158_exc_T9
Value
= 130µmol/L/
NCT02394158_exc_T10
Measurement
alanine transaminase
NCT02394158_exc_T11
Value
= 2.0 x upper limit normal
NCT02394158_exc_T12
Condition
intolerance
NCT02394158_exc_T13
Drug
metformin
NCT02394158_exc_T14
Scope
fasting plasma glucose = 7.0mmol/L and/ or HbA1c = 48mmol/mol
NCT02394158_exc_T15
Scope
creatinine = 130µmol/L/ alanine transaminase = 2.0 x upper limit normal/ previous intolerance to metformin