1. Prior Therapy Exposure to chemotherapy or radiotherapy within 2 weeks prior to entering the study or those who have not recovered from adverse events due to agents administered more than 2 weeks earlier. Systemic steroids that have not been stabilized (≥ 5 days) to the equivalent of ≤10 mg/day prednisone prior to the start of the study drugs. No other investigational agents are allowed. 
2. History of allergic reactions to TGR-1202 or carfilzomib 
3. Uncontrolled inter-current illness 
4. Pregnant women 
5. Nursing women 
6. Current malignancy or history of a prior malignancy 
7. Patient known to be Human Immunodeficiency Virus (HIV)-positive 
8. Active Hepatitis A, Hepatitis B, or Hepatitis C infection       
    

NCT02867618_exc_T10
Temporal
Prior
NCT02867618_exc_T11
Procedure
chemotherapy
NCT02867618_exc_T9
Procedure
radiotherapy
NCT02867618_exc_T12
Temporal
within 2 weeks prior
NCT02867618_exc_T13
Reference_point
entering the study
NCT02867618_exc_T14
Scope
chemotherapy or radiotherapy
NCT02867618_exc_T15
Condition
recovered
NCT02867618_exc_T16
Negation
not
NCT02867618_exc_T17
Condition
adverse events
NCT02867618_exc_T19
Drug
agents
NCT02867618_exc_T20
Temporal
more than 2 weeks earlier
NCT02867618_exc_T21
Drug
Systemic steroids
NCT02867618_exc_T22
Qualifier
stabilized
NCT02867618_exc_T23
Negation
not
NCT02867618_exc_T24
Temporal
≥ 5 days
NCT02867618_exc_T25
Multiplier
≤10 mg/day
NCT02867618_exc_T26
Drug
prednisone
NCT02867618_exc_T27
Temporal
prior to
NCT02867618_exc_T28
Reference_point
start of the study drugs
NCT02867618_exc_T29
Drug
other investigational agents
NCT02867618_exc_T32
Condition
allergic reactions
NCT02867618_exc_T33
Drug
TGR-1202
NCT02867618_exc_T34
Drug
carfilzomib
NCT02867618_exc_T35
Scope
TGR-1202 or carfilzomib
NCT02867618_exc_T36
Observation
History
NCT02867618_exc_T37
Condition
inter-current illness
NCT02867618_exc_T38
Qualifier
Uncontrolled
NCT02867618_exc_T40
Temporal
inter-current
NCT02867618_exc_T41
Person
women
NCT02867618_exc_T42
Condition
Pregnant
NCT02867618_exc_T43
Person
women
NCT02867618_exc_T44
Condition
Nursing
NCT02867618_exc_T45
Condition
malignancy
NCT02867618_exc_T46
Temporal
Current
NCT02867618_exc_T47
Condition
malignancy
NCT02867618_exc_T48
Observation
history of a prior
NCT02867618_exc_T49
Measurement
Human Immunodeficiency Virus (HIV)
NCT02867618_exc_T50
Value
positive
NCT02867618_exc_T51
Condition
Hepatitis A
NCT02867618_exc_T52
Condition
Hepatitis B
NCT02867618_exc_T53
Condition
Hepatitis C