Is not of reproductive potential, or is of reproductive potential and agrees to avoid becoming pregnant or impregnating a partner while receiving trial medication or within 6 months after the last dose of trial medication
Has chronic back pain of =3 months duration by history
Has physician-diagnosed active nr-axSpA with disease duration <= 5 years
• Inflammatory back pain
• Arthritis (physician-diagnosed)
• Enthesitis (heel) physician-diagnosed (spontaneous pain or tenderness at examination of the site of the insertion of the Achilles tendon or plantar fascia)
• Dactylitis (physician-diagnosed)
• Psoriasis (physician-diagnosed)
• History of physician-diagnosed inflammatory bowel disease (IBD)
• History of uveitis confirmed by an ophthalmologist
• Good response to nonsteroidal anti-inflammatory drugs (NSAID)
• Family history of SpA (presence of ankylosing spondylitis, psoriasis, acute uveitis, reactive arthritis, or IBD)
• Elevated CRP
• Human leukocyte antigen B27 (HLA-B27)+ gene
Has a HLA-B27+ gene and 2 or more of the SpA characteristics listed above
Has elevated CRP at Screening or evidence of active inflammation in the sacroiliac joints on MRI
Has an ASDAS >= 2.1 at Screening
Shows high disease activity at Screening and Baseline of both a Total Back Pain score of =4 and a Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score of >= 4
Has an acceptable history of NSAID use
Has no history of untreated latent or active tuberculosis (TB) prior to Screening
Has had no recent close contact with a person with active TB or, if there has been such contact, will undergo additional evaluations and receive appropriate treatment for latent TB

NCT03253796_inc_T2
Condition
chronic back pain
NCT03253796_inc_T3
Qualifier
=3 months duration
NCT03253796_inc_T4
Observation
history
NCT03253796_inc_T5
Condition
nr-axSpA
NCT03253796_inc_T6
Qualifier
active
NCT03253796_inc_T7
Measurement
disease duration
NCT03253796_inc_T8
Measurement
duration
NCT03253796_inc_T9
Value
=3 months
NCT03253796_inc_T10
Value
<= 5 years
NCT03253796_inc_T11
Qualifier
disease duration <= 5 years
NCT03253796_inc_T12
Condition
Inflammatory back pain
NCT03253796_inc_T13
Condition
Arthritis
NCT03253796_inc_T14
Condition
Enthesitis
NCT03253796_inc_T15
Qualifier
heel
NCT03253796_inc_T16
Condition
pain
NCT03253796_inc_T17
Condition
tenderness
NCT03253796_inc_T18
Qualifier
site of the insertion of the Achilles tendon
NCT03253796_inc_T19
Qualifier
plantar fascia
NCT03253796_inc_T20
Scope
site of the insertion of the Achilles tendon or plantar fascia
NCT03253796_inc_T21
Scope
pain or tenderness
NCT03253796_inc_T22
Condition
Dactylitis
NCT03253796_inc_T23
Condition
Psoriasis
NCT03253796_inc_T24
Condition
inflammatory bowel disease (IBD)
NCT03253796_inc_T25
Condition
uveitis
NCT03253796_inc_T27
Observation
History
NCT03253796_inc_T28
Observation
History
NCT03253796_inc_T29
Drug
nonsteroidal anti-inflammatory drugs (NSAID)
NCT03253796_inc_T30
Observation
Good response
NCT03253796_inc_T31
Observation
Family history
NCT03253796_inc_T32
Condition
SpA
NCT03253796_inc_T33
Condition
ankylosing spondylitis
NCT03253796_inc_T34
Condition
psoriasis
NCT03253796_inc_T35
Condition
acute uveitis
NCT03253796_inc_T36
Condition
reactive arthritis
NCT03253796_inc_T37
Condition
IBD
NCT03253796_inc_T38
Scope
ankylosing spondylitis, psoriasis, acute uveitis, reactive arthritis, or IBD
NCT03253796_inc_T39
Measurement
CRP
NCT03253796_inc_T40
Value
Elevated
NCT03253796_inc_T41
Condition
A-B2 te antigen B27 (HLA-B27)+ g
NCT03253796_inc_T42
Condition
(HLA-B27)+
NCT03253796_inc_T43
Condition
HLA-B27+
NCT03253796_inc_T44
Condition
SpA
NCT03253796_inc_T45
Multiplier
2 or more
NCT03253796_inc_T46
Measurement
CRP
NCT03253796_inc_T47
Value
elevated
NCT03253796_inc_T48
Temporal
at Screening
NCT03253796_inc_T49
Qualifier
active
NCT03253796_inc_T50
Condition
inflammation
NCT03253796_inc_T51
Qualifier
sacroiliac joints
NCT03253796_inc_T52
Procedure
MRI
NCT03253796_inc_T53
Measurement
ASDAS
NCT03253796_inc_T54
Value
>= 2.1
NCT03253796_inc_T55
Temporal
at Screening
NCT03253796_inc_T56
Measurement
Total Back Pain score
NCT03253796_inc_T57
Value
=4
NCT03253796_inc_T58
Measurement
Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) score
NCT03253796_inc_T59
Value
>= 4
NCT03253796_inc_T60
Condition
high disease activity
NCT03253796_inc_T61
Temporal
at Screening and Baseline
NCT03253796_inc_T62
Observation
history
NCT03253796_inc_T63
Qualifier
acceptable
NCT03253796_inc_T64
Drug
NSAID
NCT03253796_inc_T65
Qualifier
active
NCT03253796_inc_T66
Qualifier
untreated
NCT03253796_inc_T67
Qualifier
latent
NCT03253796_inc_T68
Condition
tuberculosis (TB)
NCT03253796_inc_T69
Scope
latent or active
NCT03253796_inc_T70
Negation
no
NCT03253796_inc_T71
Observation
history
NCT03253796_inc_T72
Scope
history of untreated latent or active tuberculosis (TB)
NCT03253796_inc_T73
Temporal
prior to Screening
NCT03253796_inc_T74
Reference_point
Screening
NCT03253796_inc_T75
Observation
close contact
NCT03253796_inc_T76
Temporal
recent
NCT03253796_inc_T77
Observation
person with active TB