1) pregnancy, breast-feeding women, or female patients of childbearing potential but did not take contraceptive measures;2) existing severe acute infection and is not controlled; or purulent and chronic infection, delayed healing wounds; 3) the original severe heart disease, including congestive heart failure, uncontrolled high-risk arrhythmias, unstable angina, myocardial infarction, severe heart valve disease and resistant hypertension; 4) suffering from neurological and psychiatric diseases or mental disorders is not easy to control, poor compliance, and can not be described with treatment responders; primary brain or central nervous metastasis disease has not been controlled, with significant cranial hypertension or neuropsychiatric symptoms; 5) have bleeding tendencies; 6) other researchers believe that patients should not participate in the present trial.

NCT02804646_exc_T8
Qualifier
severe
NCT02804646_exc_T9
Qualifier
acute
NCT02804646_exc_T10
Condition
infection
NCT02804646_exc_T11
Qualifier
not controlled
NCT02804646_exc_T12
Qualifier
chronic
NCT02804646_exc_T13
Qualifier
purulent
NCT02804646_exc_T14
Condition
infection
NCT02804646_exc_T15
Condition
delayed healing wounds
NCT02804646_exc_T16
Scope
purulent and chronic infection, delayed healing wounds
NCT02804646_exc_T17
Qualifier
severe
NCT02804646_exc_T18
Condition
heart disease
NCT02804646_exc_T19
Condition
congestive heart failure
NCT02804646_exc_T20
Qualifier
uncontrolled
NCT02804646_exc_T21
Qualifier
high-risk
NCT02804646_exc_T22
Condition
arrhythmias
NCT02804646_exc_T23
Condition
unstable angina
NCT02804646_exc_T24
Condition
myocardial infarction
NCT02804646_exc_T25
Qualifier
severe
NCT02804646_exc_T26
Condition
heart valve disease
NCT02804646_exc_T27
Qualifier
resistant
NCT02804646_exc_T28
Condition
hypertension
NCT02804646_exc_T29
Scope
congestive heart failure, uncontrolled high-risk arrhythmias, unstable angina, myocardial infarction, severe heart valve disease and resistant hypertension
NCT02804646_exc_T30
Condition
psychiatric diseases
NCT02804646_exc_T31
Condition
neurological diseases
NCT02804646_exc_T32
Condition
mental disorders
NCT02804646_exc_T33
Condition
poor compliance
NCT02804646_exc_T34
Condition
central nervous metastasis disease
NCT02804646_exc_T35
Condition
primary brain disease
NCT02804646_exc_T36
Negation
not
NCT02804646_exc_T37
Qualifier
controlled
NCT02804646_exc_T38
Scope
primary brain or central nervous metastasis disease
NCT02804646_exc_T39
Qualifier
significant
NCT02804646_exc_T40
Condition
cranial hypertension
NCT02804646_exc_T41
Condition
neuropsychiatric symptoms
NCT02804646_exc_T42
Condition
bleeding tendencies
NCT02804646_exc_T43
Scope
cranial hypertension or neuropsychiatric symptoms