Male or female patients = 18 and = 85 years of age
Women of child bearing potential must test negative on standard pregnancy test (urine or serum)
Patients with body weight = 55 kg and = 140 kg and body mass index (BMI) = 18 kg/m2
Patients diagnosed severe sepsis / septic shock at admission on Intensive Care Unit who can be enrolled within 90 min after admission OR patients diagnosed severe sepsis / septic shock during Intensive Care Unit stay who can be enrolled within 90 min after diagnosis
Patients where antibiotic therapy has already been started (prior to randomization)
Patient who are fluid responsive. Fluid responsiveness is defined as increase of > 10% in mean arterial pressure (MAP) after passive leg raising (PLR)
Signed informed consent by patient, legal representative or authorized person or deferred consent

NCT02715466_inc_T1
Person
Male
NCT02715466_inc_T2
Person
female
NCT02715466_inc_T3
Value
= 18 and = 85 years
NCT02715466_inc_T4
Person
age
NCT02715466_inc_T5
Person
Women
NCT02715466_inc_T6
Condition
child bearing potential
NCT02715466_inc_T7
Measurement
standard pregnancy test
NCT02715466_inc_T8
Value
negative
NCT02715466_inc_T9
Measurement
urine
NCT02715466_inc_T10
Measurement
serum
NCT02715466_inc_T11
Scope
urine or serum
NCT02715466_inc_T12
Scope
Women of child bearing potential
NCT02715466_inc_T13
Measurement
body weight
NCT02715466_inc_T14
Value
= 55 kg and = 140 kg
NCT02715466_inc_T15
Measurement
body mass index (BMI)
NCT02715466_inc_T16
Value
= 18 kg/m2
NCT02715466_inc_T17
Condition
severe sepsis
NCT02715466_inc_T18
Condition
septic shock
NCT02715466_inc_T19
Temporal
at admission on Intensive Care Unit
NCT02715466_inc_T20
Reference_point
admission on Intensive Care Unit
NCT02715466_inc_T22
Drug
antibiotic therapy
NCT02715466_inc_T23
Temporal
prior to randomization
NCT02715466_inc_T24
Reference_point
randomization
NCT02715466_inc_T25
Condition
fluid responsive
NCT02715466_inc_T26
Measurement
mean arterial pressure (MAP)
NCT02715466_inc_T27
Qualifier
after passive leg raising (PLR)
NCT02715466_inc_T28
Value
> 10%