Diagnosis of Heart Failure;
Lower left ventricular ejection fraction 45% (LVEF <45%) assessed by simple and recent echocardiogram;
Functional Class II and III by the New York Heart Association (NYHA)
Clinically stable;
Ex-smokers over five years;
Maximal inspiratory pressure (MIP) <70% of predicted;
Forced expiratory volume/Forced vital capacity (FEV1 / FVC) > 70% of predicted;

NCT02600000_inc_T1
Condition
Heart Failure
NCT02600000_inc_T2
Measurement
Lower left ventricular ejection fraction
NCT02600000_inc_T3
Value
45%
NCT02600000_inc_T4
Measurement
LVEF
NCT02600000_inc_T5
Value
<45%
NCT02600000_inc_T6
Scope
LVEF <45%
NCT02600000_inc_T7
Scope
Lower left ventricular ejection fraction 45%
NCT02600000_inc_T8
Procedure
echocardiogram
NCT02600000_inc_T9
Temporal
recent
NCT02600000_inc_T10
Measurement
New York Heart Association (NYHA)
NCT02600000_inc_T11
Value
Class II and III
NCT02600000_inc_T12
Condition
Clinically stable
NCT02600000_inc_T13
Condition
Ex-smokers
NCT02600000_inc_T14
Temporal
over five years
NCT02600000_inc_T15
Measurement
Maximal inspiratory pressure (MIP)
NCT02600000_inc_T16
Value
<70% of predicted
NCT02600000_inc_T17
Measurement
Forced expiratory volume/Forced vital capacity (FEV1 / FVC)
NCT02600000_inc_T18
Value
> 70% of predicted