Subjects with poor-controlled arterial hypertension (systolic blood pressure> 140 mmHg and diastolic blood pressure > 90 mm Hg) despite standard medical management; Coronary heart disease greater than ClassII; II-level arrhythmia (including QT interval prolongation, for man = 450 ms, for woman = 470 ms) together with Class II cardiac dysfunction;
Factors that could have an effect on oral medication (such as inability to swallow, chronic diarrhea and intestinal obstruction);
Subjects with high gastrointestinal bleeding risk, including the following conditions: local active ulcer lesions with positive fecal occult blood test (++); history of black stool, or vomiting blood in the past 3 months;unresected primary lesion in stomach with positive fecal occult blood test (+), ulcerated gastric carcinoma with massive alimentary tract bleeding risk judged by PIs based on gastric endoscopy result;
Abnormal Coagulation (INR>1.5<U+3001>APTT>1.5 UNL), with tendency of bleed;
Associated with CNS (central nervous system) metastases;
Pregnant or lactating women;
Other conditions regimented at investigators' discretion.

NCT02426034_exc_T1
Condition
arterial hypertension
NCT02426034_exc_T2
Qualifier
poor-controlled
NCT02426034_exc_T3
Measurement
systolic blood pressure
NCT02426034_exc_T4
Value
> 140 mmHg
NCT02426034_exc_T5
Measurement
diastolic blood pressure
NCT02426034_exc_T6
Value
> 90 mm Hg
NCT02426034_exc_T7
Scope
systolic blood pressure> 140 mmHg and diastolic blood pressure > 90 mm Hg
NCT02426034_exc_T8
Condition
Coronary heart disease
NCT02426034_exc_T9
Qualifier
greater than ClassII
NCT02426034_exc_T10
Condition
arrhythmia
NCT02426034_exc_T11
Qualifier
II-level
NCT02426034_exc_T12
Qualifier
Subjects
NCT02426034_exc_T13
Condition
QT interval prolongation
NCT02426034_exc_T14
Condition
cardiac dysfunction
NCT02426034_exc_T15
Qualifier
Class II
NCT02426034_exc_T16
Scope
II-level arrhythmia (including QT interval prolongation, for man = 450 ms, for woman = 470 ms) together with Class II cardiac dysfunction
NCT02426034_exc_T17
Condition
inability to swallow
NCT02426034_exc_T18
Condition
chronic diarrhea
NCT02426034_exc_T19
Condition
intestinal obstruction
NCT02426034_exc_T20
Observation
gastrointestinal bleeding risk
NCT02426034_exc_T21
Qualifier
high
NCT02426034_exc_T22
Condition
ulcer lesions
NCT02426034_exc_T23
Qualifier
active
NCT02426034_exc_T24
Measurement
fecal occult blood test
NCT02426034_exc_T25
Value
positive
NCT02426034_exc_T26
Value
++
NCT02426034_exc_T27
Condition
black stool
NCT02426034_exc_T28
Condition
vomiting blood
NCT02426034_exc_T29
Temporal
past 3 months
NCT02426034_exc_T30
Scope
black stool, or vomiting blood
NCT02426034_exc_T31
Condition
primary lesion
NCT02426034_exc_T32
Qualifier
stomach
NCT02426034_exc_T33
Measurement
fecal occult blood test
NCT02426034_exc_T34
Value
positive
NCT02426034_exc_T35
Value
+
NCT02426034_exc_T36
Condition
ulcerated gastric carcinoma
NCT02426034_exc_T37
Qualifier
alimentary tract
NCT02426034_exc_T38
Qualifier
massive
NCT02426034_exc_T39
Observation
bleeding risk
NCT02426034_exc_T40
Scope
local active ulcer lesions with positive fecal occult blood test (++); history of black stool, or vomiting blood in the past 3 months;unresected primary lesion in stomach with positive fecal occult blood test (+), ulcerated gastric carcinoma with massive alimentary tract bleeding risk judged by PIs based on gastric endoscopy result
NCT02426034_exc_T41
Condition
Abnormal Coagulation
NCT02426034_exc_T42
Measurement
INR
NCT02426034_exc_T43
Value
>1.5
NCT02426034_exc_T44
Measurement
APTT
NCT02426034_exc_T45
Value
>1.5 UNL
NCT02426034_exc_T46
Condition
tendency of bleed
NCT02426034_exc_T47
Scope
INR>1.5<U+3001>APTT>1.5 UNL
NCT02426034_exc_T48
Condition
stases;
Pr (ce