Participant has a clinically significant abnormal physical examination, vital signs or 12 lead ECG (including QTc greater than (>) 450msec, Left Bundle Branch Block, permanent pacemaker or implantable cardioverter defibrillator) at Screening or admission 
Participant has a history of or current liver or renal insufficiency; significant cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances 
Use of any prescription or over-the-counter medication, herbal medication, vitamins, or mineral supplements within 14 days prior to study drug administration (not including paracetamol). Medication for chronic use in age related disease will be allowed after approval by both the investigator and to the sponsor. No change in dose or regimen will be permitted during the study that is, from the Screening visit until the follow-up visit 
Participant has a history of spontaneous, prolonged or severe bleeding of unclear origin 
Participant has a history of epilepsy or fits or unexplained black-outs other than vasovagal collapse       
    

NCT02260700_exc_T2
Qualifier
clinically significant
NCT02260700_exc_T3
Condition
abnormal physical examination
NCT02260700_exc_T5
Condition
abnormal vital signs
NCT02260700_exc_T6
Condition
abnormal 12 lead ECG
NCT02260700_exc_T7
Measurement
QTc
NCT02260700_exc_T8
Value
greater than (>) 450msec
NCT02260700_exc_T9
Condition
Left Bundle Branch Block
NCT02260700_exc_T10
Device
permanent pacemaker
NCT02260700_exc_T11
Condition
implantable cardioverter defibrillator
NCT02260700_exc_T12
Scope
QTc greater than (>) 450msec, Left Bundle Branch Block, permanent pacemaker or implantable cardioverter defibrillator
NCT02260700_exc_T13
Temporal
at Screening or admission
NCT02260700_exc_T14
Reference_point
Screening
NCT02260700_exc_T15
Reference_point
admission
NCT02260700_exc_T16
Scope
Screening or admission
NCT02260700_exc_T17
Scope
abnormal physical examination, vital signs or 12 lead ECG
NCT02260700_exc_T18
Condition
renal insufficiency
NCT02260700_exc_T19
Condition
liver insufficiency
NCT02260700_exc_T20
Observation
history
NCT02260700_exc_T21
Condition
metabolic disturbances
NCT02260700_exc_T22
Condition
psychiatric disturbances
NCT02260700_exc_T23
Condition
rheumatologic disturbances
NCT02260700_exc_T24
Condition
hematologic disturbances
NCT02260700_exc_T25
Condition
neurologic disturbances
NCT02260700_exc_T26
Condition
endocrine disturbances
NCT02260700_exc_T27
Condition
gastrointestinal disturbances
NCT02260700_exc_T28
Condition
pulmonary disturbances
NCT02260700_exc_T29
Condition
vascular disturbances
NCT02260700_exc_T30
Condition
cardiac disturbances
NCT02260700_exc_T31
Scope
cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances
NCT02260700_exc_T32
Qualifier
significant
NCT02260700_exc_T35
Scope
liver or renal insufficiency; significant cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic, hematologic, rheumatologic, psychiatric, or metabolic disturbances
NCT02260700_exc_T36
Drug
any prescription
NCT02260700_exc_T38
Drug
over-the-counter medication
NCT02260700_exc_T40
Drug
herbal medication
NCT02260700_exc_T41
Drug
vitamins
NCT02260700_exc_T42
Drug
mineral supplements
NCT02260700_exc_T43
Temporal
within 14 days prior to study drug administration
NCT02260700_exc_T44
Reference_point
study drug administration
NCT02260700_exc_T45
Drug
paracetamol
NCT02260700_exc_T46
Negation
not
NCT02260700_exc_T47
Scope
any prescription or over-the-counter medication, herbal medication, vitamins, or mineral supplements
NCT02260700_exc_T48
Drug
Medication
NCT02260700_exc_T49
Condition
age related disease
NCT02260700_exc_T51
Multiplier
chronic use
NCT02260700_exc_T56
Condition
bleeding
NCT02260700_exc_T57
Qualifier
unclear origin
NCT02260700_exc_T58
Qualifier
severe
NCT02260700_exc_T59
Qualifier
prolonged
NCT02260700_exc_T60
Qualifier
spontaneous
NCT02260700_exc_T61
Observation
history
NCT02260700_exc_T62
Scope
spontaneous, prolonged or severe
NCT02260700_exc_T64
Condition
epilepsy
NCT02260700_exc_T65
Condition
fits
NCT02260700_exc_T66
Condition
black-outs
NCT02260700_exc_T67
Qualifier
unexplained
NCT02260700_exc_T68
Condition
vasovagal collapse
NCT02260700_exc_T69
Negation
other than
NCT02260700_exc_T70
Observation
history
NCT02260700_exc_T71
Scope
epilepsy or fits or unexplained black-outs other than vasovagal collapse