History of ischaemic heart disease, cardiac failure, cerebrovascular disease, liver impairment (ALT/AST>50IU/L) or stage 3-5 chronic kidney disease.
History of overdose or suicidal ideation
Patients weighing <55kgs.
Patients with chronic pain requiring treatment, with a known allergy to paracetamol, or concomitant use of non-steroidal anti-inflammatories , oral anticoagulants or corticosteroids.

NCT01997112_exc_T1
Condition
ischaemic heart disease
NCT01997112_exc_T2
Condition
cardiac failure
NCT01997112_exc_T3
Condition
cerebrovascular disease
NCT01997112_exc_T4
Condition
liver impairment
NCT01997112_exc_T5
Measurement
ALT
NCT01997112_exc_T6
Measurement
AST
NCT01997112_exc_T7
Value
>50IU/L
NCT01997112_exc_T8
Measurement
stage
NCT01997112_exc_T9
Value
3-5
NCT01997112_exc_T10
Condition
chronic kidney disease
NCT01997112_exc_T11
Scope
ALT/AST>50IU/L
NCT01997112_exc_T12
Condition
overdose
NCT01997112_exc_T13
Condition
suicidal ideation
NCT01997112_exc_T14
Measurement
weighing
NCT01997112_exc_T15
Value
<55kgs
NCT01997112_exc_T16
Condition
chronic pain
NCT01997112_exc_T17
Qualifier
requiring treatment
NCT01997112_exc_T18
Condition
known allergy
NCT01997112_exc_T19
Drug
paracetamol
NCT01997112_exc_T20
Drug
non-steroidal anti-inflammatories
NCT01997112_exc_T21
Temporal
concomitant
NCT01997112_exc_T22
Drug
oral anticoagulants
NCT01997112_exc_T23
Drug
corticosteroids
NCT01997112_exc_T24
Scope
non-steroidal anti-inflammatories , oral anticoagulants or corticosteroids