Healthy Volunteers 
Treprostinil contraindications: Known hypersensitivity to treprostinil or any of the excipients, Pulmonary arterial hypertension related to veno-occlusive disease, Congestive heart failure due to severe left ventricular dysfunction, Severe hepatic insufficiency (Child-Pugh stage C), Evolving gastrointestinal ulcer, intracranial hemorrhage, recent trauma or other clinical condition that may lead to bleeding, Congenital or acquired valvular abnormalities with cardiac repercussions, Severe ischemic heart disease or unstable angina; Myocardial infarction in the last six months; Decompensated cardiac insufficiency not medically controlled; Severe arrhythmias; Cerebrovascular lesions (such as transient ischemic attack, stroke) that occurred within the last three months. 
Persons referred to in Articles L1121-5 to L1121-8 of the French Public health Code: pregnant woman, parturient, nursing mother, person deprived of liberty by judicial or administrative decision, person subject to a legal protection measure, can not Be included in clinical trials. 
Subject in an exclusion period from another study, 
Subject who would receive more than 4500 euros of compensation due to his participation in other biomedical research in the 12 months preceding this study 
Systemic sclerosis patients: 
Iloprost cure carried out in the previous month or planned in the following month. 
Initiation or change of dosage of bosentan, sildenafil or calcium channel blockers in the previous month or in the following month 
Digital Sympathectomy or botulinum toxin injection planned in the following month. 
Clinically superinfected digital ulcers 
Treprostinil contraindications: Known hypersensitivity to treprostinil or any of the excipients, Pulmonary arterial hypertension related to veno-occlusive disease, Congestive heart failure due to severe left ventricular dysfunction, Severe hepatic insufficiency (Child-Pugh stage C), Evolving gastrointestinal ulcer, intracranial hemorrhage, recent trauma or other clinical condition that may lead to bleeding, Congenital or acquired valvular abnormalities with cardiac repercussions, Severe ischemic heart disease or unstable angina; Myocardial infarction in the last six months; Decompensated cardiac insufficiency not medically controlled; Severe arrhythmias; Cerebrovascular lesions (such as transient ischemic attack, stroke) that occurred within the last three months. 
Persons referred to in Articles L1121-5 to L1121-8 of the French Public health Code: pregnant woman, parturient, nursing mother, person deprived of liberty by judicial or administrative decision, person subject to a legal protection measure, can not Be included in clinical trials. 
Subject in an exclusion period from another study, 
Subject who would receive more than 4500 euros of compensation due to his participation in other biomedical research in the 12 months preceding this study       
    

NCT03120533_exc_T2
Condition
contraindications
NCT03120533_exc_T3
Drug
Treprostinil
NCT03120533_exc_T4
Condition
hypersensitivity
NCT03120533_exc_T5
Drug
treprostinil
NCT03120533_exc_T6
Drug
any of the excipients
NCT03120533_exc_T7
Condition
Pulmonary arterial hypertension
NCT03120533_exc_T8
Condition
veno-occlusive disease
NCT03120533_exc_T9
Condition
Congestive heart failure
NCT03120533_exc_T10
Condition
left ventricular dysfunction
NCT03120533_exc_T11
Condition
hepatic insufficiency
NCT03120533_exc_T12
Qualifier
severe
NCT03120533_exc_T13
Qualifier
Severe
NCT03120533_exc_T14
Measurement
Child-Pugh
NCT03120533_exc_T15
Value
stage C
NCT03120533_exc_T16
Condition
gastrointestinal ulcer
NCT03120533_exc_T17
Qualifier
Evolving
NCT03120533_exc_T18
Condition
intracranial hemorrhage
NCT03120533_exc_T19
Condition
trauma
NCT03120533_exc_T20
Temporal
recent
NCT03120533_exc_T21
Condition
clinical condition that may lead to bleeding
NCT03120533_exc_T23
Condition
Congenital valvular abnormalities
NCT03120533_exc_T24
Condition
acquired valvular abnormalities
NCT03120533_exc_T25
Qualifier
with cardiac repercussions
NCT03120533_exc_T26
Condition
ischemic heart disease
NCT03120533_exc_T27
Qualifier
Severe
NCT03120533_exc_T28
Condition
unstable angina
NCT03120533_exc_T29
Condition
Myocardial infarction
NCT03120533_exc_T30
Temporal
in the last six months
NCT03120533_exc_T31
Condition
Decompensated cardiac insufficiency
NCT03120533_exc_T32
Qualifier
not medically controlled
NCT03120533_exc_T33
Condition
arrhythmias
NCT03120533_exc_T34
Qualifier
Severe
NCT03120533_exc_T35
Condition
Cerebrovascular lesions
NCT03120533_exc_T36
Condition
transient ischemic attack
NCT03120533_exc_T37
Condition
stroke
NCT03120533_exc_T38
Scope
transient ischemic attack, stroke
NCT03120533_exc_T39
Temporal
within the last three months
NCT03120533_exc_T41
Condition
pregnant
NCT03120533_exc_T42
Person
woman
NCT03120533_exc_T43
Condition
parturient
NCT03120533_exc_T44
Condition
nursing
NCT03120533_exc_T45
Observation
deprived of liberty
NCT03120533_exc_T46
Scope
pregnant woman, parturient, nursing mother, person deprived of liberty
NCT03120533_exc_T51
Condition
Systemic sclerosis
NCT03120533_exc_T52
Drug
Iloprost
NCT03120533_exc_T53
Temporal
in the previous month
NCT03120533_exc_T54
Temporal
in the following month
NCT03120533_exc_T55
Observation
planned
NCT03120533_exc_T56
Drug
Iloprost
NCT03120533_exc_T58
Drug
bosentan
NCT03120533_exc_T59
Drug
sildenafil
NCT03120533_exc_T60
Drug
calcium channel blockers
NCT03120533_exc_T61
Temporal
in the previous month
NCT03120533_exc_T62
Temporal
in the following month
NCT03120533_exc_T63
Scope
in the previous month or in the following month
NCT03120533_exc_T64
Scope
bosentan, sildenafil or calcium channel blockers
NCT03120533_exc_T65
Procedure
Digital Sympathectomy
NCT03120533_exc_T66
Procedure
botulinum toxin injection
NCT03120533_exc_T67
Observation
planned
NCT03120533_exc_T69
Temporal
in the following month
NCT03120533_exc_T70
Scope
Digital Sympathectomy or botulinum toxin injection
NCT03120533_exc_T71
Condition
digital ulcers
NCT03120533_exc_T72
Observation
superinfected
NCT03120533_exc_T73
Drug
Treprostinil
NCT03120533_exc_T74
Condition
contraindications
NCT03120533_exc_T75
Condition
hypersensitivity
NCT03120533_exc_T76
Drug
treprostinil
NCT03120533_exc_T77
Drug
any of the excipients
NCT03120533_exc_T78
Scope
treprostinil or any of the excipients
NCT03120533_exc_T79
Condition
Pulmonary arterial hypertension
NCT03120533_exc_T80
Condition
veno-occlusive disease
NCT03120533_exc_T81
Condition
Congestive heart failure
NCT03120533_exc_T82
Condition
left ventricular dysfunction
NCT03120533_exc_T83
Qualifier
severe
NCT03120533_exc_T84
Condition
hepatic insufficiency
NCT03120533_exc_T85
Qualifier
Severe
NCT03120533_exc_T86
Measurement
Child-Pugh
NCT03120533_exc_T87
Value
stage C
NCT03120533_exc_T88
Condition
gastrointestinal ulcer
NCT03120533_exc_T89
Condition
intracranial hemorrhage
NCT03120533_exc_T90
Condition
trauma
NCT03120533_exc_T91
Temporal
recent
NCT03120533_exc_T92
Condition
clinical condition that may lead to bleeding
NCT03120533_exc_T94
Condition
Congenital valvular abnormalities
NCT03120533_exc_T95
Condition
acquired valvular abnormalities
NCT03120533_exc_T96
Qualifier
with cardiac repercussions
NCT03120533_exc_T97
Condition
ischemic heart disease
NCT03120533_exc_T98
Qualifier
Severe
NCT03120533_exc_T99
Condition
unstable angina
NCT03120533_exc_T100
Condition
Myocardial infarction
NCT03120533_exc_T101
Temporal
in the last six months
NCT03120533_exc_T102
Condition
Decompensated cardiac insufficiency
NCT03120533_exc_T103
Condition
arrhythmias
NCT03120533_exc_T104
Qualifier
Severe
NCT03120533_exc_T105
Condition
Cerebrovascular lesions
NCT03120533_exc_T106
Condition
transient ischemic attack
NCT03120533_exc_T107
Condition
stroke
NCT03120533_exc_T108
Temporal
within the last three months
NCT03120533_exc_T109
Scope
transient ischemic attack, stroke
NCT03120533_exc_T110
Scope
recent trauma
NCT03120533_exc_T112
Condition
pregnant
NCT03120533_exc_T113
Person
woman
NCT03120533_exc_T114
Condition
parturient
NCT03120533_exc_T115
Condition
nursing
NCT03120533_exc_T116
Observation
deprived of liberty
NCT03120533_exc_T117
Observation
subject to a legal protection
NCT03120533_exc_T118
Scope
pregnant woman, parturient, nursing mother, person deprived of liberty by judicial or administrative decision, person subject to a legal protection