Psychotic depression by DSM-IV, i.e., presence of delusions with a SCID-R score higher than 2;
High suicide risk, i.e. intent or plan to attempt suicide in near future;
Presence of any Axis I psychiatric disorder (other than unipolar major depression) or substance abuse;
History of psychiatric disorders other than unipolar major depression or generalized anxiety disorder (bipolar disorder, hypomania, and dysthymia are exclusion criteria);
Dementia: Diagnosis of dementia by DSM-IV;
Mild Cognitive Impairment (MCI);
Acute or severe medical illness, i.e., delirium, metastatic cancer, decompensated cardiac, liver or kidney failure, major surgery, stroke or myocardial infarction during the three months prior to entry; or use of drugs known to cause depression, e.g., reserpine, alpha-methyl-dopa, steroids, sympathomimetics withdrawal;
Neurological brain disease and/or history of electroconvulsive therapy;
History of any use of citalopram or escitalopram during the current episode or need for drugs that may interact with these agents, i.e. drug metabolized by the 2D6 P450 isoenzyme system;
Current involvement in psychotherapy;
Contraindications to MRI scanning including cardiac pacemaker, metallic objects and metallic implants contraindicating MRI, cardiac stent, claustrophobia;
Inability to speak English;
Corrected visual acuity < 20/70; Color blindness.

NCT01728194_exc_T1
Condition
Psychotic depression
NCT01728194_exc_T2
Qualifier
DSM-IV
NCT01728194_exc_T3
Condition
delusions
NCT01728194_exc_T4
Measurement
SCID-R score
NCT01728194_exc_T5
Value
higher than 2
NCT01728194_exc_T6
Observation
suicide risk
NCT01728194_exc_T7
Qualifier
High
NCT01728194_exc_T8
Mood
intent
NCT01728194_exc_T9
Mood
plan to
NCT01728194_exc_T10
Observation
attempt suicide
NCT01728194_exc_T11
Temporal
in near future
NCT01728194_exc_T12
Scope
intent or plan to
NCT01728194_exc_T13
Condition
psychiatric disorder
NCT01728194_exc_T14
Qualifier
Axis I
NCT01728194_exc_T15
Negation
other than
NCT01728194_exc_T16
Condition
unipolar major depression
NCT01728194_exc_T17
Condition
substance abuse
NCT01728194_exc_T18
Scope
Axis I psychiatric disorder (other than unipolar major depression
NCT01728194_exc_T19
Condition
psychiatric disorders
NCT01728194_exc_T20
Negation
other than
NCT01728194_exc_T21
Condition
unipolar major depression
NCT01728194_exc_T22
Condition
generalized anxiety disorder
NCT01728194_exc_T23
Condition
bipolar disorder
NCT01728194_exc_T24
Condition
hypomania
NCT01728194_exc_T25
Condition
dysthymia
NCT01728194_exc_T27
Scope
unipolar major depression or generalized anxiety disorder
NCT01728194_exc_T26
Scope
bipolar disorder, hypomania, and dysthymia
NCT01728194_exc_T28
Condition
Dementia
NCT01728194_exc_T29
Qualifier
DSM-IV
NCT01728194_exc_T30
Condition
Mild Cognitive Impairment
NCT01728194_exc_T31
Condition
MCI
NCT01728194_exc_T32
Condition
medical illness
NCT01728194_exc_T33
Qualifier
Acute
NCT01728194_exc_T34
Qualifier
severe
NCT01728194_exc_T35
Condition
delirium
NCT01728194_exc_T36
Condition
metastatic cancer
NCT01728194_exc_T37
Qualifier
decompensated
NCT01728194_exc_T38
Condition
c, live e, majo
NCT01728194_exc_T39
Condition
or ki e, majo
NCT01728194_exc_T40
Condition
kidney failure
NCT01728194_exc_T41
Procedure
major surgery
NCT01728194_exc_T42
Condition
stroke
NCT01728194_exc_T43
Condition
myocardial infarction
NCT01728194_exc_T44
Temporal
three months prior to entry
NCT01728194_exc_T45
Reference_point
entry
NCT01728194_exc_T46
Drug
drugs
NCT01728194_exc_T47
Condition
depression
NCT01728194_exc_T48
Drug
reserpine
NCT01728194_exc_T49
Drug
alpha-methyl-dopa
NCT01728194_exc_T50
Drug
steroids
NCT01728194_exc_T51
Condition
sympathomimetics withdrawal
NCT01728194_exc_T52
Scope
Acute or severe
NCT01728194_exc_T53
Scope
delirium, metastatic cancer, decompensated cardiac, liver or kidney failure, major surgery, stroke or myocardial infarction
NCT01728194_exc_T54
Scope
cardiac, liver or kidney failure
NCT01728194_exc_T55
Scope
reserpine, alpha-methyl-dopa, steroids, sympathomimetics withdrawal
NCT01728194_exc_T56
Condition
brain disease
NCT01728194_exc_T57
Qualifier
Neurological
NCT01728194_exc_T58
Procedure
electroconvulsive therapy
NCT01728194_exc_T59
Drug
citalopram
NCT01728194_exc_T60
Drug
escitalopram
NCT01728194_exc_T61
Qualifier
current
NCT01728194_exc_T62
Condition
episode
NCT01728194_exc_T63
Scope
citalopram or escitalopram
NCT01728194_exc_T64
Drug
drugs
NCT01728194_exc_T65
Drug
agents
NCT01728194_exc_T67
Procedure
psychotherapy
NCT01728194_exc_T68
Condition
Contraindications
NCT01728194_exc_T69
Procedure
MRI
NCT01728194_exc_T70
Device
cardiac pacemaker
NCT01728194_exc_T71
Device
metallic objects
NCT01728194_exc_T72
Device
metallic implants
NCT01728194_exc_T73
Device
cardiac stent
NCT01728194_exc_T74
Condition
claustrophobia
NCT01728194_exc_T75
Scope
cardiac pacemaker, metallic objects and metallic implants contraindicating MRI, cardiac stent, claustrophobia
NCT01728194_exc_T77
Measurement
visual acuity
NCT01728194_exc_T78
Qualifier
Corrected
NCT01728194_exc_T79
Value
< 20/70;
NCT01728194_exc_T80
Condition
Color blindness