Prior treatment with more than 6 cycles of traditional alkylating agent-based chemotherapy regimens 
Prior treatment with more than 2 cycles of carboplating-based chemotherapy regimens 
For colorectal cancer patients in the expanded cohorts, prior treatment with more than 2 systemic chemotherapy regimens in the metastatic setting       
    

NCT00599924_exc_T1
Procedure
treatment
NCT00599924_exc_T2
Temporal
Prior
NCT00599924_exc_T3
Procedure
chemotherapy regimens
NCT00599924_exc_T4
Qualifier
alkylating agent-based
NCT00599924_exc_T5
Value
more than 6 cycles
NCT00599924_exc_T6
Qualifier
carboplating-based
NCT00599924_exc_T7
Value
more than 2 cycles
NCT00599924_exc_T8
Procedure
treatment
NCT00599924_exc_T9
Temporal
Prior
NCT00599924_exc_T10
Procedure
chemotherapy regimens
NCT00599924_exc_T11
Condition
colorectal cancer
NCT00599924_exc_T12
Procedure
treatment
NCT00599924_exc_T13
Temporal
prior
NCT00599924_exc_T14
Value
more than 2
NCT00599924_exc_T15
Procedure
systemic chemotherapy regimens
NCT00599924_exc_T16
Qualifier
metastatic