History of documented clotting/coagulation disorder
History of cancer (within the last year)
Any diagnosis requiring anti-coagulation
History of hypersensitivity reaction to apixaban
Active clinically significant bleeding
Creatinine > 1.5 mg/dL
Participants currently receiving any type of anticoagulation or blood thinning medications, including heparin, low molecular weight heparins, Plavix, aspirin, NSAIDS
Combined P-glycoprotein and strong cytochrome P450 (CYP) 3A4 inhibitor
Combined P-glycoprotein and moderate CYP 3A4 inhibitor
Combined P-glycoprotein inducer and strong CYP 3A4 inducer
Inducers of p-glycoprotein
Strong inducers of CYP 3A4

NCT02406885_exc_T1
Condition
coagulation disorder
NCT02406885_exc_T2
Condition
clotting disorder
NCT02406885_exc_T3
Condition
cancer
NCT02406885_exc_T4
Temporal
last year
NCT02406885_exc_T5
Drug
anti-coagulation
NCT02406885_exc_T6
Condition
hypersensitivity
NCT02406885_exc_T7
Drug
apixaban
NCT02406885_exc_T8
Condition
bleeding
NCT02406885_exc_T9
Qualifier
significant
NCT02406885_exc_T10
Qualifier
Active
NCT02406885_exc_T11
Measurement
Creatinine
NCT02406885_exc_T12
Value
> 1.5 mg/dL
NCT02406885_exc_T13
Drug
anticoagulation
NCT02406885_exc_T14
Drug
blood thinning medications
NCT02406885_exc_T15
Drug
heparin
NCT02406885_exc_T16
Drug
low molecular weight heparins
NCT02406885_exc_T17
Drug
Plavix
NCT02406885_exc_T18
Drug
aspirin
NCT02406885_exc_T19
Drug
NSAIDS
NCT02406885_exc_T20
Scope
anticoagulation or blood thinning medications
NCT02406885_exc_T21
Scope
heparin, low molecular weight heparins, Plavix, aspirin, NSAIDS
NCT02406885_exc_T22
Drug
protein and st or
Combin
NCT02406885_exc_T23
Drug
ome P450 (CYP) ibitor
Combin
NCT02406885_exc_T24
Qualifier
strong
NCT02406885_exc_T25
Drug
rotein and mod r
Combine
NCT02406885_exc_T26
Drug
CYP 3A4 inhibitor
NCT02406885_exc_T27
Qualifier
moderate
NCT02406885_exc_T28
Drug
P-glycoprotein inducer
NCT02406885_exc_T29
Drug
CYP 3A4 inducer
NCT02406885_exc_T30
Qualifier
strong
NCT02406885_exc_T31
Drug
Inducers of p-glycoprotein
NCT02406885_exc_T32
Drug
inducers of CYP 3A4
NCT02406885_exc_T33
Qualifier
Strong