Age less than 10 years or greater than 55 years, at time of consent 
Estimated IQ < 70 
Uncontrolled epilepsy (seizure within 6 months prior to consent) 
4. Presence of medical conditions that might interfere with participation, or where participation would be contraindicated 
History of neurological injury: head trauma, poorly-controlled seizure disorder (seizure within the preceding six months), stroke, prior neurosurgery, or under the care of a neurologist or neurosurgeon as determined by interview 
History of claustrophobia 
Implanted or irremovable metal in the body (including certain tattoos and permanent make-up) 
Current pregnancy (as verified by testing prior to both initial dose administration of citalopram or placebo and prior to magnetic resonance imaging) due to the risk that may be associated with SSRI treatment and magnetic resonance imaging on fetal health 
Medical contraindications to SSRI therapy as determined by history (including induction of mania or hypomania during SSRI therapy, or known drug allergy) 
Concomitant medication that would interfere with study participation 
Prior history of citalopram treatment failure at appropriate doses and duration 
Prior history of treatment failure to two previous SSRI trials at appropriate doses and duration 
Ongoing need for psychoactive medication other than study medication [excepting stable doses (greater than three months duration) of anticonvulsant medication for seizure disorder, or diphenhydramine (Benadryl®)for sleep]       
    

NCT00609531_exc_T1
Person
Age
NCT00609531_exc_T2
Value
less than 10 years
NCT00609531_exc_T3
Value
greater than 55 years
NCT00609531_exc_T4
Scope
less than 10 years or greater than 55 years
NCT00609531_exc_T5
Temporal
at time of consent
NCT00609531_exc_T6
Measurement
Estimated IQ
NCT00609531_exc_T7
Value
< 70
NCT00609531_exc_T8
Condition
Uncontrolled epilepsy
NCT00609531_exc_T9
Value
within 6 months prior to consent
NCT00609531_exc_T10
Condition
seizure
NCT00609531_exc_T12
Condition
neurological injury
NCT00609531_exc_T13
Observation
History
NCT00609531_exc_T14
Condition
head trauma
NCT00609531_exc_T15
Condition
seizure disorder
NCT00609531_exc_T16
Qualifier
poorly-controlled
NCT00609531_exc_T17
Condition
seizure
NCT00609531_exc_T18
Temporal
within the preceding six months
NCT00609531_exc_T19
Condition
stroke
NCT00609531_exc_T20
Condition
neurosurgery
NCT00609531_exc_T21
Temporal
prior
NCT00609531_exc_T22
Observation
under the care of a neurologist
NCT00609531_exc_T23
Observation
under the care of a neurosurgeon
NCT00609531_exc_T24
Scope
head trauma, poorly-controlled seizure disorder (seizure within the preceding six months), stroke, prior neurosurgery, or under the care of a neurologist or neurosurgeon
NCT00609531_exc_T25
Condition
claustrophobia
NCT00609531_exc_T26
Observation
History
NCT00609531_exc_T27
Device
Implanted metal in the body
NCT00609531_exc_T28
Device
irremovable metal in the body
NCT00609531_exc_T29
Condition
pregnancy
NCT00609531_exc_T30
Temporal
Current
NCT00609531_exc_T32
Condition
contraindications to SSRI therapy
NCT00609531_exc_T33
Condition
mania
NCT00609531_exc_T34
Temporal
during SSRI therapy
NCT00609531_exc_T35
Condition
hypomania
NCT00609531_exc_T36
Scope
mania or hypomania
NCT00609531_exc_T37
Condition
drug allergy
NCT00609531_exc_T38
Observation
history
NCT00609531_exc_T40
Drug
citalopram
NCT00609531_exc_T41
Observation
history
NCT00609531_exc_T42
Temporal
Prior
NCT00609531_exc_T43
Procedure
treatment
NCT00609531_exc_T44
Qualifier
failure
NCT00609531_exc_T47
Drug
psychoactive medication
NCT00609531_exc_T48
Drug
study medication
NCT00609531_exc_T51
Temporal
greater than three months
NCT00609531_exc_T52
Drug
anticonvulsant medication
NCT00609531_exc_T53
Condition
seizure disorder
NCT00609531_exc_T54
Drug
diphenhydramine
NCT00609531_exc_T55
Scope
excepting stable doses (greater than three months duration) of anticonvulsant medication for seizure disorder, or diphenhydramine (Benadryl®)for sleep
NCT00609531_exc_T56
Negation
other than
NCT00609531_exc_T49
Negation
excepting
NCT00609531_exc_T57
Observation
consent
NCT00609531_exc_T58
Reference_point
consent
NCT00609531_exc_T59
Procedure
SSRI therapy
NCT00609531_exc_T60
Scope
mania or hypomania during SSRI therapy, or known drug allergy