Patients with liver cirrhosis, Hepatocellular Carcinoma or AFP >2 ULN or other malignancies.
Patients with other factors causing liver diseases.
Pregnant and lactating women.
Patients with concomitant HIV infection or congenital immune deficiency diseases.
Patients with diabetes, autoimmune diseases.
Patients with important organ dysfunctions.
Patients with serious complications (e.g., infection, hepatic encephalopathy, hepatorenal syndrome, gastrointestinal bleeding.)
Patients who receive antineoplastic or immunomodulatory therapy in the past 12 months.
Patients with a previous use of IFN anti hepatitis B virus treatment or have NAs drug resistance.
Patients who can't come back to clinic for follow-up on schedule.

NCT02838810_exc_T1
Condition
liver cirrhosis
NCT02838810_exc_T2
Condition
Hepatocellular Carcinoma
NCT02838810_exc_T3
Measurement
AFP
NCT02838810_exc_T4
Value
>2 ULN
NCT02838810_exc_T5
Condition
malignancies
NCT02838810_exc_T6
Condition
liver diseases
NCT02838810_exc_T9
Condition
HIV infection
NCT02838810_exc_T10
Qualifier
concomitant
NCT02838810_exc_T11
Condition
congenital immune deficiency diseases
NCT02838810_exc_T12
Condition
diabetes
NCT02838810_exc_T13
Condition
autoimmune diseases
NCT02838810_exc_T14
Condition
organ dysfunctions
NCT02838810_exc_T15
Qualifier
important
NCT02838810_exc_T16
Qualifier
serious
NCT02838810_exc_T17
Condition
complications
NCT02838810_exc_T18
Condition
infection
NCT02838810_exc_T19
Condition
hepatic encephalopathy
NCT02838810_exc_T20
Condition
hepatorenal syndrome
NCT02838810_exc_T21
Condition
gastrointestinal bleeding
NCT02838810_exc_T22
Scope
infection, hepatic encephalopathy, hepatorenal syndrome, gastrointestinal bleeding
NCT02838810_exc_T23
Procedure
plastic or imm  in th
NCT02838810_exc_T24
Procedure
immunomodulatory therapy
NCT02838810_exc_T25
Scope
antineoplastic or immunomodulatory therapy
NCT02838810_exc_T26
Temporal
past 12 months
NCT02838810_exc_T27
Drug
IFN
NCT02838810_exc_T28
Qualifier
anti hepatitis B virus
NCT02838810_exc_T29
Condition
resistance
NCT02838810_exc_T30
Drug
NAs drug