Evidence of low ovarian reserve by at least one of the following: AMH = 1,5 ng/mL and/or basal CD 3 FSH = 10 mIU/mL and/or basal CD 3 Estradiol = 60 ng/mL and/or previous egg collection yield = 3 oocytes.
Preexisting medical condition (thyroid disease, diabetes mellitus, hypertension, pulmonary conditions, cardiac condition…).
Severe male factor infertility (Total motile sperm count < 5 million/ml and/or normal WHO morphology <20%).
Hypersensitivity to Heparin or its derivatives.
Acquired thrombophilia.
Active hemorrhage or increased risk of bleeding due to impairment of homeostasis.
Severe impairment of liver or pancreatic function.
Severe renal insufficiency (Creatinine Clearance < 30 ml/min).
Injuries to or operations on the central nervous system, eyes and ears within the last 2 months.
Disseminated Intravascular Coagulation (DIC) attributable to heparin-induced thrombocytopenia.
Acute bacterial endocarditis and endocarditis lenta.
Any organic lesion with high risk of bleeding (e.g.: active peptic ulcer, hemorrhagic stroke, cerebral aneurysm or cerebral neoplasms).

NCT02607319_exc_T1
Condition
low ovarian reserve
NCT02607319_exc_T3
Measurement
AMH
NCT02607319_exc_T2
Value
= 1,5 ng/mL
NCT02607319_exc_T4
Measurement
basal CD 3 FSH
NCT02607319_exc_T5
Value
= 10 mIU/mL
NCT02607319_exc_T6
Measurement
basal CD 3 Estradiol
NCT02607319_exc_T7
Value
= 60 ng/mL
NCT02607319_exc_T8
Measurement
egg collection yield
NCT02607319_exc_T9
Value
= 3 oocytes
NCT02607319_exc_T10
Scope
AMH = 1,5 ng/mL and/or basal CD 3 FSH = 10 mIU/mL and/or basal CD 3 Estradiol = 60 ng/mL and/or previous egg collection yield = 3 oocytes
NCT02607319_exc_T11
Condition
thyroid disease
NCT02607319_exc_T12
Condition
diabetes mellitus
NCT02607319_exc_T13
Condition
hypertension
NCT02607319_exc_T14
Condition
pulmonary conditions
NCT02607319_exc_T15
Condition
cardiac condition
NCT02607319_exc_T16
Condition
male factor infertility
NCT02607319_exc_T17
Qualifier
Severe
NCT02607319_exc_T18
Measurement
Total motile sperm count
NCT02607319_exc_T19
Value
< 5 million/ml
NCT02607319_exc_T20
Measurement
normal WHO morphology
NCT02607319_exc_T21
Value
<20%
NCT02607319_exc_T22
Scope
Total motile sperm count < 5 million/ml and/or normal WHO morphology <20%
NCT02607319_exc_T23
Condition
Hypersensitivity
NCT02607319_exc_T24
Drug
Heparin
NCT02607319_exc_T25
Condition
thrombophilia
NCT02607319_exc_T26
Qualifier
Acquired
NCT02607319_exc_T27
Condition
Active hemorrhage
NCT02607319_exc_T28
Observation
risk of bleeding
NCT02607319_exc_T29
Qualifier
increased
NCT02607319_exc_T30
Condition
impairment of homeostasis
NCT02607319_exc_T31
Condition
impairment of liver
NCT02607319_exc_T32
Condition
ment of liver atic function.
Seve
NCT02607319_exc_T33
Scope
impairment of liver or pancreatic function
NCT02607319_exc_T34
Qualifier
Severe
NCT02607319_exc_T35
Qualifier
Severe
NCT02607319_exc_T36
Condition
renal insufficiency
NCT02607319_exc_T37
Measurement
Creatinine Clearance
NCT02607319_exc_T38
Value
< 30 ml/min
NCT02607319_exc_T39
Procedure
operations
NCT02607319_exc_T40
Condition
Injuries
NCT02607319_exc_T41
Qualifier
central nervous system
NCT02607319_exc_T42
Qualifier
eyes
NCT02607319_exc_T43
Qualifier
ears
NCT02607319_exc_T44
Temporal
last 2 months
NCT02607319_exc_T45
Scope
central nervous system, eyes and ears
NCT02607319_exc_T46
Scope
Injuries to or operations
NCT02607319_exc_T47
Condition
Disseminated Intravascular Coagulation
NCT02607319_exc_T48
Condition
DIC
NCT02607319_exc_T49
Condition
heparin-induced thrombocytopenia
NCT02607319_exc_T50
Condition
endocarditis lenta
NCT02607319_exc_T51
Condition
Acute bacterial endocarditis
NCT02607319_exc_T52
Condition
organic lesion
NCT02607319_exc_T53
Observation
risk of bleeding
NCT02607319_exc_T54
Qualifier
high
NCT02607319_exc_T55
Condition
active peptic ulcer
NCT02607319_exc_T56
Condition
hemorrhagic stroke
NCT02607319_exc_T57
Condition
cerebral aneurysm
NCT02607319_exc_T58
Condition
cerebral neoplasms
NCT02607319_exc_T59
Scope
active peptic ulcer, hemorrhagic stroke, cerebral aneurysm or cerebral neoplasms