Age over 18 years,
General Condition WHO 0, 1 or 2,
ASA Class I and II, eligible for endoscopic or surgical treatment with curative intent,
Histological diagnosis of high grade glandular epithelial neoplasia (Vienna 4-1 to 4-46), possibly multifocal or stage 0 (Tis, N0, M0),
Endoscopic and histological confirmed diagnosis of intestinal metaplasia,
Histological diagnosis confirmed by two endoscopies with biopsies and two pathological readings; biopsies should be carried out according to the protocol of the SFED (four-quadrant biopsies every cm) with at least once acetic acid for staining. Operators describe Barrett's esophagus using he SFED planimetric model. The final exam will be no more than two months before the date of treatment and should have been achieved in investigator establishment,
Minimum 1 cm,
Maximum 12 cm.
the resected lesion must have been well differentiated and confined to the mucosa (m2 maximum) on histological analysis,
resection should be more than two months,
resection must have been macroscopically complete laterally,
resection must have been histologically complete in depth,
resection must have been histologically complete laterally with regard to the microinvasive cancer, that is to say with a clear margin of safety (margin may be high-grade dysplasia provided that the latter has not macroscopic translation),
At least one endoscopic and histologic follow-up should be conducted with dye in a period of less than two months before the date of treatment, and at the investigator establishment.
Patient may take an inhibitor of proton pump equivalent to 2 times 40 mg of esomeprazole,
No mediastinal or celiac, or suspected metastatic lymph nodes by EUS,
Affiliation to a social security system or similar,
Lack of participation in another clinical study,
Informed consent signed.

NCT02558504_inc_T1
Person
Age
NCT02558504_inc_T2
Value
over 18 years
NCT02558504_inc_T3
Measurement
General Condition WHO
NCT02558504_inc_T4
Value
0
NCT02558504_inc_T5
Value
1
NCT02558504_inc_T6
Value
2
NCT02558504_inc_T7
Scope
0, 1 or 2
NCT02558504_inc_T8
Measurement
ASA Class
NCT02558504_inc_T9
Value
I
NCT02558504_inc_T10
Value
II
NCT02558504_inc_T11
Scope
I and II
NCT02558504_inc_T12
Mood
eligible for
NCT02558504_inc_T13
Procedure
eatment w doscopic o
NCT02558504_inc_T14
Procedure
surgical treatment
NCT02558504_inc_T15
Qualifier
with curative intent
NCT02558504_inc_T16
Scope
endoscopic or surgical treatment
NCT02558504_inc_T17
Procedure
Histological diagnosis
NCT02558504_inc_T18
Condition
glandular epithelial neoplasia
NCT02558504_inc_T19
Measurement
Vienna
NCT02558504_inc_T20
Value
4-1 to 4-46
NCT02558504_inc_T21
Qualifier
high grade
NCT02558504_inc_T22
Qualifier
multifocal
NCT02558504_inc_T23
Measurement
stage
NCT02558504_inc_T24
Value
0
NCT02558504_inc_T25
Measurement
T
NCT02558504_inc_T26
Measurement
N
NCT02558504_inc_T27
Measurement
M
NCT02558504_inc_T28
Value
0
NCT02558504_inc_T29
Value
0
NCT02558504_inc_T30
Value
is
NCT02558504_inc_T31
Scope
Tis, N0, M0
NCT02558504_inc_T32
Scope
stage 0
NCT02558504_inc_T33
Qualifier
histological confirmed
NCT02558504_inc_T34
Qualifier
scopic and irmed dia
NCT02558504_inc_T35
Condition
intestinal metaplasia
NCT02558504_inc_T36
Procedure
histological
NCT02558504_inc_T37
Procedure
Endoscopic
NCT02558504_inc_T38
Scope
Endoscopic and histological confirmed
NCT02558504_inc_T39
Qualifier
Histological
NCT02558504_inc_T40
Procedure
Histological
NCT02558504_inc_T41
Multiplier
two
NCT02558504_inc_T42
Procedure
endoscopies
NCT02558504_inc_T43
Procedure
biopsies
NCT02558504_inc_T44
Multiplier
two
NCT02558504_inc_T45
Procedure
pathological readings
NCT02558504_inc_T46
Condition
diagnosis
NCT02558504_inc_T52
Condition
resected lesion
NCT02558504_inc_T53
Qualifier
well differentiated
NCT02558504_inc_T54
Qualifier
confined to the mucosa
NCT02558504_inc_T55
Qualifier
m2 maximum
NCT02558504_inc_T56
Procedure
histological analysis
NCT02558504_inc_T57
Condition
resection
NCT02558504_inc_T58
Temporal
more than two months
NCT02558504_inc_T59
Condition
resection
NCT02558504_inc_T60
Qualifier
macroscopically complete laterally
NCT02558504_inc_T61
Condition
resection
NCT02558504_inc_T62
Procedure
histologically
NCT02558504_inc_T63
Qualifier
complete in depth
NCT02558504_inc_T64
Condition
resection
NCT02558504_inc_T65
Procedure
histologically
NCT02558504_inc_T66
Qualifier
complete laterally
NCT02558504_inc_T68
Condition
microinvasive cancer
NCT02558504_inc_T71
Qualifier
metastatic
NCT02558504_inc_T72
Qualifier
celiac
NCT02558504_inc_T73
Qualifier
mediastinal
NCT02558504_inc_T74
Scope
mediastinal or celiac, or suspected metastatic
NCT02558504_inc_T75
Condition
lymph nodes
NCT02558504_inc_T76
Procedure
EUS
NCT02558504_inc_T77
Negation
No
NCT02558504_inc_T78
Observation
Affiliation to a social security system
NCT02558504_inc_T79
Negation
Lack of
NCT02558504_inc_T80
Observation
another clinical nformed consen
NCT02558504_inc_T81
Qualifier
another
NCT02558504_inc_T82
Observation
Informed consent signed