Patients who may receive therapeutically effective doses via an external beam approach to the lesion of interest as specified by MSKCC Radiation Oncology Department dose constraint criteria. 
Patients with kyphoplasty cement or hardware that would preclude effective catheter placement. 
Patients with paraspinal extension of disease with visceral involvement. 
Abnormal complete blood count. Any of the following: 
Platelet count < 75,000/ml 
Hb level < 9gm/dl 
WBC < 3.5/ml 
Abnormal coagulation profile: INR > 2.5 and/or PTT > 80 
Patients who are on anticoagulation medication that may not be safely held for the procedure (≥ 5 days for antiplatelet agents and warfarin; ≥ 24 hours for low-molecular weight heparin formulations) will be excluded. 
Contraindications to general anesthesia       
    

NCT01757717_exc_T1
Measurement
MSKCC Radiation Oncology Department dose constraint criteria
NCT01757717_exc_T2
Condition
may receive therapeutically effective doses via an external beam approach to the lesion of interest
NCT01757717_exc_T3
Qualifier
therapeutically effective
NCT01757717_exc_T4
Procedure
doses
NCT01757717_exc_T5
Procedure
external beam
NCT01757717_exc_T7
Device
kyphoplasty cement
NCT01757717_exc_T8
Device
kyphoplasty hardware
NCT01757717_exc_T9
Qualifier
preclude effective catheter placement
NCT01757717_exc_T10
Scope
kyphoplasty cement or hardware
NCT01757717_exc_T11
Condition
paraspinal extension of disease
NCT01757717_exc_T12
Condition
visceral involvement
NCT01757717_exc_T13
Measurement
complete blood count
NCT01757717_exc_T14
Value
Abnormal
NCT01757717_exc_T15
Condition
Abnormal complete blood count
NCT01757717_exc_T18
Measurement
Platelet count
NCT01757717_exc_T19
Value
< 75,000/ml
NCT01757717_exc_T20
Measurement
Hb level
NCT01757717_exc_T21
Value
< 9gm/dl
NCT01757717_exc_T22
Measurement
WBC
NCT01757717_exc_T23
Value
< 3.5/ml
NCT01757717_exc_T24
Measurement
coagulation profile
NCT01757717_exc_T25
Value
Abnormal
NCT01757717_exc_T26
Condition
Abnormal coagulation profile
NCT01757717_exc_T27
Measurement
INR
NCT01757717_exc_T28
Value
> 2.5
NCT01757717_exc_T29
Measurement
PTT
NCT01757717_exc_T30
Value
> 80
NCT01757717_exc_T31
Scope
INR > 2.5 and/or PTT > 80
NCT01757717_exc_T32
Drug
anticoagulation medication
NCT01757717_exc_T34
Qualifier
may not be safely held for the procedure
NCT01757717_exc_T36
Multiplier
≥ 5 days
NCT01757717_exc_T37
Drug
antiplatelet agents
NCT01757717_exc_T38
Drug
warfarin
NCT01757717_exc_T39
Multiplier
≥ 24 hours
NCT01757717_exc_T40
Drug
low-molecular weight heparin
NCT01757717_exc_T41
Scope
≥ 5 days for antiplatelet agents and warfarin
NCT01757717_exc_T42
Scope
≥ 24 hours for low-molecular weight heparin
NCT01757717_exc_T43
Scope
≥ 5 days for antiplatelet agents and warfarin; ≥ 24 hours for low-molecular weight heparin
NCT01757717_exc_T44
Scope
anticoagulation medication that may not be safely held for the procedure
NCT01757717_exc_T45
Condition
Contraindications to general anesthesia
NCT01757717_exc_T46
Procedure
general anesthesia