1. Left main disease (angiographically> 50%) 
2. Cardiogenic shock / hemodynamic instability 
3. Previous CABG 
4. Increased risk of bradycardia on investigator clinical judgment 
5. Severe chronic obstructive pulmonary disease 
6. Coronary vessels with tortuosity or extremely calcified 
7. Severe left ventricular hypertrophy or severe valvular disease 
8. STEMI or non-STEMI within the past five days 
9. Previous myocardial infarction in the distribution of the target vessel for the FFR 
10. Acute decompensated heart failure.       
    

NCT02350439_exc_T11
Condition
Left main disease
NCT02350439_exc_T12
Value
> 50%
NCT02350439_exc_T14
Condition
Cardiogenic shock
NCT02350439_exc_T15
Condition
hemodynamic instability
NCT02350439_exc_T16
Condition
CABG
NCT02350439_exc_T17
Temporal
Previous
NCT02350439_exc_T18
Condition
bradycardia
NCT02350439_exc_T22
Qualifier
Increased risk
NCT02350439_exc_T23
Condition
chronic obstructive pulmonary disease
NCT02350439_exc_T24
Qualifier
Severe
NCT02350439_exc_T25
Condition
Coronary vessel tortuosity
NCT02350439_exc_T26
Condition
Coronary vessel extremely calcified
NCT02350439_exc_T27
Condition
left ventricular hypertrophy
NCT02350439_exc_T28
Qualifier
Severe
NCT02350439_exc_T29
Condition
valvular disease
NCT02350439_exc_T30
Qualifier
severe
NCT02350439_exc_T31
Condition
STEMI
NCT02350439_exc_T32
Condition
non-STEMI
NCT02350439_exc_T33
Temporal
within the past five days
NCT02350439_exc_T34
Condition
myocardial infarction
NCT02350439_exc_T35
Temporal
Previous
NCT02350439_exc_T36
Qualifier
in the distribution of the target vessel
NCT02350439_exc_T37
Condition
Acute decompensated heart failure