Men and women aged > 18 years
Angiographically confirmed acute massive pulmonary embolism with involvement of Central pulmonary arteries.
endovascular mechanical thrombus fragmentation + thrombolytic therapy (using recombinant tissue activator of plasminogen), performed for treatment of the above-mentioned pulmonary embolism in less than 48 hours before randomization. The patient should be randomized no earlier than 24 hours after procedures endovascular mechanical thrombus fragmentation + thrombolytic therapy
Written informed consent signed by patient.

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Person
Men
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Person
women
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Person
aged
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Value
> 18 years
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Procedure
Angiographically
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Qualifier
Angiographically confirmed
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Qualifier
acute
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Qualifier
massive
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Condition
pulmonary embolism
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Condition
involvement of Central pulmonary arteries
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Condition
endovascular mechanical thrombus fragmentation
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Procedure
thrombolytic therapy
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Drug
recombinant tissue activator of plasminogen
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Temporal
in less than 48 hours before randomization
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Procedure
treatment
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Condition
pulmonary embolism
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Scope
endovascular mechanical thrombus fragmentation + thrombolytic therapy (using recombinant tissue activator of plasminogen)