Overlap syndrome with Primary Sclerosing Cholangitis (PSC) or Primary Biliary Cholangitis (PBC) (Paris criteria, strong positive Anti-Mitochondrial Antibodies (AMA), past liver biopsy or cholangiographic findings compatible with PBC or PSC).
Presentation with acute liver failure, defined as presence of hepatic encephalopathy and coagulopathy (INR > 1.5)
Current treatment with prednisone/prednisolone and/or immunosuppressive medication for an indication other than autoimmune hepatitis
Current systemic infection
Other clinically significant medical conditions that could interfere with the trial
If female of childbearing potential: known pregnancy, or unwilling to practice anticontraceptive measures.
History of noncompliance with medical regimens, or patients who are considered to be potentially unreliable or unable to participate
Mental instability or incompetence, such that the validity of informed consent or compliance with the trial is uncertain

NCT02900443_exc_T1
Condition
Overlap syndrome
NCT02900443_exc_T2
Condition
Primary Sclerosing Cholangitis
NCT02900443_exc_T3
Condition
PSC
NCT02900443_exc_T4
Condition
Primary Biliary Cholangitis
NCT02900443_exc_T5
Condition
PBC
NCT02900443_exc_T6
Measurement
Paris criteria,
NCT02900443_exc_T7
Measurement
Anti-Mitochondrial Antibodies
NCT02900443_exc_T8
Value
strong positive
NCT02900443_exc_T9
Measurement
AMA
NCT02900443_exc_T10
Procedure
liver biopsy
NCT02900443_exc_T11
Procedure
cholangiographic findings
NCT02900443_exc_T12
Condition
PBC
NCT02900443_exc_T13
Condition
PSC
NCT02900443_exc_T14
Scope
Primary Sclerosing Cholangitis (PSC) or Primary Biliary Cholangitis (PBC)
NCT02900443_exc_T15
Scope
liver biopsy or cholangiographic findings
NCT02900443_exc_T16
Scope
PBC or PSC
NCT02900443_exc_T17
Condition
acute liver failure
NCT02900443_exc_T18
Condition
hepatic encephalopathy
NCT02900443_exc_T19
Condition
coagulopathy
NCT02900443_exc_T20
Measurement
INR
NCT02900443_exc_T21
Value
> 1.5
NCT02900443_exc_T22
Scope
hepatic encephalopathy and coagulopathy (INR > 1.5)
NCT02900443_exc_T23
Drug
prednisone
NCT02900443_exc_T24
Drug
prednisolone
NCT02900443_exc_T25
Drug
immunosuppressive medication
NCT02900443_exc_T26
Condition
autoimmune hepatitis
NCT02900443_exc_T27
Negation
other
NCT02900443_exc_T28
Condition
indication
NCT02900443_exc_T29
Scope
prednisone/prednisolone and/or immunosuppressive medication
NCT02900443_exc_T30
Condition
systemic infection