Before participate in the study, patients must understand the treatment plan and willing to participate in the study. Patients must have signed an approved informed consent.
Histopathologic confirmed squamous cell carcinoma of head and neck ,including oral cavity, oropharynx, larynx, or hypopharynx.
Ages=65 years,Not limited to gender.
ECOG performance status =2.
Patients with surgical contraindication or reject to surgery.
Postoperative TNM(primary tumor,regional nodes,metastasis) staging III~IV, positive surgical margin.
without evidence of distant metastases.
No contraindication to chemoradiotherapy.
Life expectancy > 3 months.
Available Organ function: white blood cell=3.5×109/L, Neutrophils =1.5×109/L, Hemoglobin =80g/L, Blood platelet>100×109/L; Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST)= 2.5 upper limit of normal(ULN); Total bilirubin (TBIL) <1.5 ULN;serum creatinine=1.5 ULN; creatinine clearance of = 50ml/min

NCT03196843_inc_T2
Procedure
Histopathologic
NCT03196843_inc_T3
Condition
squamous cell carcinoma
NCT03196843_inc_T4
Qualifier
Histopathologic confirmed
NCT03196843_inc_T5
Qualifier
head and neck
NCT03196843_inc_T6
Qualifier
oral cavity
NCT03196843_inc_T7
Qualifier
oropharynx
NCT03196843_inc_T8
Qualifier
larynx
NCT03196843_inc_T9
Qualifier
hypopharynx
NCT03196843_inc_T10
Scope
oral cavity, oropharynx, larynx, or hypopharynx
NCT03196843_inc_T11
Person
Ages
NCT03196843_inc_T12
Value
=65 years
NCT03196843_inc_T13
Measurement
ECOG performance status
NCT03196843_inc_T14
Value
=2
NCT03196843_inc_T15
Condition
contraindication
NCT03196843_inc_T16
Procedure
surgical
NCT03196843_inc_T17
Observation
reject
NCT03196843_inc_T18
Procedure
surgery
NCT03196843_inc_T19
Measurement
rim ng III~
NCT03196843_inc_T20
Qualifier
Postoperative
NCT03196843_inc_T21
Value
III~IV,
NCT03196843_inc_T22
Value
positive
NCT03196843_inc_T23
Measurement
surgical margin
NCT03196843_inc_T24
Condition
distant metastases
NCT03196843_inc_T25
Negation
without
NCT03196843_inc_T26
Mood
evidence
NCT03196843_inc_T27
Condition
contraindication
NCT03196843_inc_T28
Procedure
chemoradiotherapy
NCT03196843_inc_T29
Negation
No
NCT03196843_inc_T30
Observation
Life expectancy
NCT03196843_inc_T31
Value
> 3 months
NCT03196843_inc_T32
Measurement
white blood cell
NCT03196843_inc_T33
Value
=3.5×109/L
NCT03196843_inc_T34
Measurement
Neutrophils
NCT03196843_inc_T35
Value
=1.5×109/L
NCT03196843_inc_T36
Measurement
Hemoglobin
NCT03196843_inc_T37
Value
=80g/L
NCT03196843_inc_T38
Measurement
Blood platelet
NCT03196843_inc_T39
Value
>100×109/L
NCT03196843_inc_T40
Measurement
Alanine aminotransferase (ALT)
NCT03196843_inc_T41
Measurement
Aspartate aminotransferase (AST)
NCT03196843_inc_T42
Value
= 2.5 upper limit of normal(ULN)
NCT03196843_inc_T43
Measurement
Total bilirubin (TBIL)
NCT03196843_inc_T44
Value
<1.5 ULN
NCT03196843_inc_T45
Measurement
serum creatinine
NCT03196843_inc_T46
Value
=1.5 ULN
NCT03196843_inc_T47
Measurement
creatinine clearance
NCT03196843_inc_T48
Value
= 50ml/min