Liver Transplant Recipients have received liver transplantations for at least 6+1 months prior to enrollment
Liver Transplant Recipients have no acute rejection episodes within 3 months prior to the enrollment and are clinically stable
Liver Transplant Recipients have been treated with twice-daily regimen of tacrolimus(TAC) plus everolimus(EVR) and TAC and EVR trough levels have stayed within targeted ranges for at least 6 weeks prior to enrollment
Provide written informed consent prior to inclusion.
Liver transplant recipients who are 18-65 years of age of a primary liver transplant
Allograft functioning at an acceptable level as defined by the AST, ALT, Total Bilirubin levels =3 times ULN prior to enrollment.
Abbreviated MDRD eGFR = 30 mL/min/1.73m2. 
NCT03256864_inc_T1
Person
Liver Transplant Recipients
NCT03256864_inc_T2
Procedure
liver transplantations
NCT03256864_inc_T3
Temporal
for at least 6+1 months prior to enrollment
NCT03256864_inc_T4
Reference_point
enrollment
NCT03256864_inc_T5
Person
Liver Transplant Recipients
NCT03256864_inc_T6
Negation
no
NCT03256864_inc_T7
Qualifier
acute
NCT03256864_inc_T8
Condition
rejection episodes
NCT03256864_inc_T9
Temporal
within 3 months prior to the enrollment
NCT03256864_inc_T10
Reference_point
the enrollment
NCT03256864_inc_T11
Condition
clinically stable
NCT03256864_inc_T12
Person
Liver Transplant Recipients
NCT03256864_inc_T14
Multiplier
twice-daily
NCT03256864_inc_T15
Drug
tacrolimus(TAC)
NCT03256864_inc_T16
Drug
everolimus(EVR)
NCT03256864_inc_T17
Measurement
C a ough levels h
NCT03256864_inc_T18
Measurement
EVR trough levels
NCT03256864_inc_T19
Scope
tacrolimus(TAC) plus everolimus(EVR)
NCT03256864_inc_T13
Value
within targeted ranges
NCT03256864_inc_T20
Temporal
for at least 6 weeks prior to enrollment
NCT03256864_inc_T21
Reference_point
enrollment
NCT03256864_inc_T22
Scope
TAC and EVR trough levels
NCT03256864_inc_T23
Observation
written informed consent
NCT03256864_inc_T24
Temporal
prior to inclusion
NCT03256864_inc_T25
Reference_point
inclusion
NCT03256864_inc_T26
Person
Liver transplant recipients
NCT03256864_inc_T27
Person
age
NCT03256864_inc_T28
Value
18-65 years
NCT03256864_inc_T29
Procedure
primary liver transplant
NCT03256864_inc_T30
Measurement
Allograft functioning
NCT03256864_inc_T31
Value
acceptable level
NCT03256864_inc_T32
Measurement
AST
NCT03256864_inc_T33
Measurement
ALT
NCT03256864_inc_T34
Measurement
Total Bilirubin
NCT03256864_inc_T35
Value
=3 times ULN
NCT03256864_inc_T36
Temporal
prior to enrollment
NCT03256864_inc_T37
Scope
AST, ALT, Total Bilirubin
NCT03256864_inc_T38
Scope
Allograft functioning at an acceptable level
NCT03256864_inc_T39
Scope
AST, ALT, Total Bilirubin levels =3 times ULN
NCT03256864_inc_T40
Measurement
MDRD eGFR
NCT03256864_inc_T41
Value
= 30 mL/min/1.73m2