Not available for follow-up
Pregnant or breast-feeding
Chronic pain syndrome defined as use of any analgesic medication on a daily or near-daily basis
Allergic to or intolerant of investigational medications
Contra-indications to non-steroidal anti-inflammatory drugs: 1) history of hypersensitivity to NSAIDs or aspirin 2) active or history of peptic ulcer disease, chronic dyspepsia, or active or history of gastrointestinal bleed 3) Severe heart failure (NYHA 2 or worse) 4) hypertension (JNC7 stage 2 or worse) 5) Chronic kidney disease 3 or worse 6) Current use of anti-coagulants 7) Hepatitis 8) Alcoholism
Contra-indications to muscle relaxants: 1) Concurrent use of centrally acting opioids; 2) Renal impairment; 3) Liver abnormality including cirrhosis or elevated enzymes 4) Use of any of the following medications: fluvoxamine, fluoroquinolones, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, acyclovir, ticlopidine, oral contraceptive pills

NCT03068897_exc_T2
Condition
Pregnant
NCT03068897_exc_T3
Condition
breast-feeding
NCT03068897_exc_T4
Condition
Chronic pain syndrome
NCT03068897_exc_T5
Drug
analgesic medication
NCT03068897_exc_T6
Qualifier
any
NCT03068897_exc_T7
Multiplier
 a daily  sis
A
NCT03068897_exc_T8
Multiplier
 a  ar-daily basis
A
NCT03068897_exc_T9
Scope
on a daily or near-daily basis
NCT03068897_exc_T10
Scope
any analgesic medication on a daily or near-daily basis
NCT03068897_exc_T11
Condition
Allergic
NCT03068897_exc_T12
Condition
intolerant
NCT03068897_exc_T13
Drug
investigational medications
NCT03068897_exc_T14
Scope
Allergic to or intolerant
NCT03068897_exc_T15
Condition
Contra-indications
NCT03068897_exc_T16
Drug
non-steroidal anti-inflammatory drugs
NCT03068897_exc_T17
Condition
hypersensitivity
NCT03068897_exc_T18
Drug
NSAIDs
NCT03068897_exc_T19
Drug
aspirin
NCT03068897_exc_T20
Scope
NSAIDs or aspirin
NCT03068897_exc_T21
Observation
history
NCT03068897_exc_T22
Temporal
active
NCT03068897_exc_T23
Observation
history
NCT03068897_exc_T24
Condition
peptic ulcer disease
NCT03068897_exc_T25
Condition
chronic dyspepsia
NCT03068897_exc_T26
Temporal
active
NCT03068897_exc_T27
Observation
history
NCT03068897_exc_T28
Condition
gastrointestinal bleed
NCT03068897_exc_T29
Scope
active or history
NCT03068897_exc_T30
Scope
peptic ulcer disease, chronic dyspepsia
NCT03068897_exc_T31
Scope
active or history
NCT03068897_exc_T32
Qualifier
Severe
NCT03068897_exc_T33
Condition
heart failure
NCT03068897_exc_T34
Measurement
NYHA
NCT03068897_exc_T35
Value
2 or worse
NCT03068897_exc_T36
Scope
NYHA 2 or worse
NCT03068897_exc_T37
Condition
hypertension
NCT03068897_exc_T38
Measurement
JNC7 stage
NCT03068897_exc_T39
Value
2 or worse
NCT03068897_exc_T40
Condition
Chronic kidney disease
NCT03068897_exc_T41
Temporal
Current
NCT03068897_exc_T42
Drug
anti-coagulants
NCT03068897_exc_T43
Condition
Hepatitis
NCT03068897_exc_T44
Condition
Alcoholism
NCT03068897_exc_T45
Scope
Contra-indications to non-steroidal anti-inflammatory drugs
NCT03068897_exc_T46
Scope
JNC7 stage 2 or worse
NCT03068897_exc_T47
Scope
history of hypersensitivity to NSAIDs or aspirin 2) active or history of peptic ulcer disease, chronic dyspepsia, or active or history of gastrointestinal bleed 3) Severe heart failure (NYHA 2 or worse) 4) hypertension (JNC7 stage 2 or worse) 5) Chronic kidney disease 3 or worse 6) Current use of anti-coagulants 7) Hepatitis 8) Alcoholism
NCT03068897_exc_T48
Condition
Contra-indications
NCT03068897_exc_T49
Drug
muscle relaxants
NCT03068897_exc_T50
Temporal
Concurrent
NCT03068897_exc_T51
Drug
centrally acting opioids
NCT03068897_exc_T52
Condition
Renal impairment
NCT03068897_exc_T53
Condition
Liver abnormality
NCT03068897_exc_T54
Condition
cirrhosis
NCT03068897_exc_T55
Condition
elevated enzymes
NCT03068897_exc_T56
Scope
cirrhosis or elevated enzymes
NCT03068897_exc_T57
Drug
fluvoxamine
NCT03068897_exc_T58
Drug
fluoroquinolones
NCT03068897_exc_T59
Drug
amiodarone
NCT03068897_exc_T60
Drug
mexiletine
NCT03068897_exc_T61
Drug
propafenone
NCT03068897_exc_T62
Drug
verapamil
NCT03068897_exc_T63
Drug
cimetidine
NCT03068897_exc_T64
Drug
famotidine
NCT03068897_exc_T65
Drug
acyclovir
NCT03068897_exc_T66
Drug
ticlopidine
NCT03068897_exc_T67
Drug
oral contraceptive pills
NCT03068897_exc_T68
Scope
fluvoxamine, fluoroquinolones, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, acyclovir, ticlopidine, oral contraceptive pills
NCT03068897_exc_T69
Scope
Contra-indications to muscle relaxants
NCT03068897_exc_T70
Scope
Concurrent use of centrally acting opioids; 2) Renal impairment; 3) Liver abnormality including cirrhosis or elevated enzymes 4) Use of any of the following medications: fluvoxamine, fluoroquinolones, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, acyclovir, ticlopidine, oral contraceptive pills