Patient diagnosed by HRCT Core Lab with eligible heterogeneous disease distribution and at least one complete oblique fissure. 
Age from 40 to 75 years 
BMI < 32 kg/m2 
FEV1 < 40% of predicted value, FEV1/FVC < 70% 
TLC > 120% predicted, RV > 150% predicted. 
Stable with < 20 mg prednisone (or equivalent) qd 
PaCO2 < 50mm Hg 
PaO2 > 45 mm Hg on room air 
6-min walk of > 50m (without rehabilitation) or > 100m (with rehabilitation) 
Nonsmoking for 4 months prior to initial interview and throughout screening 
The patient agrees to all protocol required follow-up intervals. 
The patient has no child bearing potential 
The patient is willing and able to complete protocol required baseline assessments and procedures 

NCT00730301_inc_T1
Procedure
HRCT Core Lab
NCT00730301_inc_T2
Condition
heterogeneous disease distribution
NCT00730301_inc_T3
Multiplier
at least one
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Condition
complete oblique fissure
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Person
Age
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Value
from 40 to 75 years
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Measurement
BMI
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Value
< 32 kg/m2
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Measurement
FEV1
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Value
< 40% of predicted value
NCT00730301_inc_T11
Measurement
FEV1/FVC
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Value
< 70%
NCT00730301_inc_T13
Measurement
TLC
NCT00730301_inc_T14
Value
> 120% predicted
NCT00730301_inc_T15
Measurement
RV
NCT00730301_inc_T16
Value
> 150% predicted
NCT00730301_inc_T17
Multiplier
< 20 mg qd
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Drug
prednisone
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Measurement
PaCO2
NCT00730301_inc_T20
Value
< 50mm Hg
NCT00730301_inc_T21
Measurement
PaO2
NCT00730301_inc_T22
Value
> 45 mm Hg
NCT00730301_inc_T23
Qualifier
on room air
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Measurement
6-min walk
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Value
> 50m
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Value
> 100m
NCT00730301_inc_T27
Negation
without
NCT00730301_inc_T28
Qualifier
rehabilitation
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Qualifier
rehabilitation
NCT00730301_inc_T30
Scope
> 50m (without rehabilitation) or > 100m (with rehabilitation)
NCT00730301_inc_T31
Condition
Nonsmoking
NCT00730301_inc_T32
Temporal
for 4 months prior to initial interview
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Reference_point
initial interview
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Temporal
throughout screening
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Reference_point
screening
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Condition
child bearing potential
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Negation
no
NCT00730301_inc_T39
Observation
willing and able to complete protocol
NCT00730301_inc_T36
Observation
agrees to all protocol required follow-up intervals
NCT00730301_inc_T40
Visit
follow-up intervals
NCT00730301_inc_T41
Procedure
baseline assessments
NCT00730301_inc_T42
Procedure
baseline procedures
NCT00730301_inc_T43
Scope
baseline assessments and procedures
NCT00730301_inc_T44
Condition
Stable