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Polytrauma; undergoing other surgeries or having other orthopedic injuries related to the precipitating cause of the ankle fracture
Infection
Peripheral vascular disease
Diabetes
Currently undergoing chemotherapy
Pregnancy
Currently lactating
Heart disease or heart rhythm disorder or taking anti-arrhythmic drugs
Severe renal impairment (Class 3 or worse kidney disease)
Liver disease (cirrhosis or liver failure)
Prior allergic reaction to any type of local anesthetic
Taking therapeutic doses of anti-coagulants or anti-platelet therapy (prophylactic doses started because of hospital admission are not an exclusion)
Currently taking antidepressants or other psychiatric medications
Single shot local nerve block prior to surgery was ineffective
Selected for neuraxial anesthesia rather than general anesthesia for the open reduction surgery
Already receiving chronic analgesic therapy for a separate chronic pain condition

NCT02950558_exc_T5
Condition
Polytrauma
NCT02950558_exc_T6
Procedure
other surgeries
NCT02950558_exc_T7
Condition
other orthopedic injuries
NCT02950558_exc_T8
Condition
ankle fracture
NCT02950558_exc_T9
Condition
Infection
NCT02950558_exc_T10
Condition
Peripheral vascular disease
NCT02950558_exc_T11
Condition
Diabetes
NCT02950558_exc_T12
Procedure
chemotherapy
NCT02950558_exc_T13
Condition
Pregnancy
NCT02950558_exc_T15
Condition
Heart disease
NCT02950558_exc_T16
Condition
heart rhythm disorder
NCT02950558_exc_T17
Drug
anti-arrhythmic drugs
NCT02950558_exc_T18
Condition
Severe renal impairment
NCT02950558_exc_T20
Condition
Liver disease
NCT02950558_exc_T21
Condition
liver failure
NCT02950558_exc_T22
Condition
cirrhosis
NCT02950558_exc_T23
Scope
cirrhosis or liver failure
NCT02950558_exc_T24
Condition
allergic reaction
NCT02950558_exc_T25
Drug
local anesthetic
NCT02950558_exc_T26
Drug
anti-coagulants
NCT02950558_exc_T27
Drug
anti-platelet therapy
NCT02950558_exc_T28
Qualifier
therapeutic
NCT02950558_exc_T29
Scope
anti-coagulants or anti-platelet therapy
NCT02950558_exc_T30
Qualifier
prophylactic
NCT02950558_exc_T31
Negation
not
NCT02950558_exc_T32
Drug
antidepressants
NCT02950558_exc_T33
Drug
psychiatric medications
NCT02950558_exc_T34
Multiplier
Single shot
NCT02950558_exc_T35
Procedure
local nerve block
NCT02950558_exc_T36
Temporal
prior to surgery
NCT02950558_exc_T37
Reference_point
surgery
NCT02950558_exc_T38
Procedure
neuraxial anesthesia
NCT02950558_exc_T39
Procedure
general anesthesia
NCT02950558_exc_T40
Negation
rather than
NCT02950558_exc_T41
Procedure
open reduction surgery
NCT02950558_exc_T42
Scope
neuraxial anesthesia rather than general anesthesia
NCT02950558_exc_T43
Procedure
analgesic therapy
NCT02950558_exc_T44
Qualifier
chronic
NCT02950558_exc_T45
Condition
chronic pain
NCT02950558_exc_T46
Qualifier
separate