Healthy Volunteers: 
Age of at least 18 years 
Existence of a contraceptive method for women of child-bearing age 
Person affiliated to social security or beneficiary of such a scheme 
Signed consent form 
Systemic sclerosis patients: 
Systemic sclerosis meeting the EULAR criteria. 
Presence of at least 2 ischemic digital cutaneous ulcerations on two different fingers, with digital ulcers classified as "active ulcers" according to the North American working group definition: epithelial denudation is clearly Visible at one place and the bed of de-epithelialized ulcer can be seen; Ulcerations distal to the proximal interphalangeal joint, not associated with calcinosis or bony relief. 
Ulcers whose major axis measured with the electronic caliper is ≥ 2 mm 
Age greater than or equal to 18 years 
Existence of a contraceptive method for women of reproductive age 
A person who is or is a beneficiary of social security 
Informed and signed consent signed by the patient or his / her legal representative. 

NCT03120533_inc_T2
Value
at least 18 years
NCT03120533_inc_T3
Person
Age
NCT03120533_inc_T4
Device
contraceptive method
NCT03120533_inc_T5
Person
women
NCT03120533_inc_T6
Value
child-bearing
NCT03120533_inc_T7
Person
age
NCT03120533_inc_T8
Scope
women of child-bearing age
NCT03120533_inc_T12
Condition
Systemic sclerosis
NCT03120533_inc_T13
Measurement
EULAR criteria
NCT03120533_inc_T14
Value
meeting
NCT03120533_inc_T15
Multiplier
at least 2 on two different fingers
NCT03120533_inc_T16
Condition
ischemic digital cutaneous ulcerations
NCT03120533_inc_T17
Condition
digital ulcers
NCT03120533_inc_T18
Qualifier
active
NCT03120533_inc_T19
Measurement
North American working group definition
NCT03120533_inc_T20
Qualifier
epithelial denudation is clearly Visible at one place and the bed of de-epithelialized ulcer can be seen; Ulcerations distal to the proximal interphalangeal joint, not associated with calcinosis or bony relief
NCT03120533_inc_T21
Condition
Ulcers
NCT03120533_inc_T22
Measurement
major axis
NCT03120533_inc_T23
Value
≥ 2 mm
NCT03120533_inc_T24
Qualifier
measured with the electronic caliper
NCT03120533_inc_T25
Person
Age
NCT03120533_inc_T26
Value
greater than or equal to 18 years
NCT03120533_inc_T27
Device
contraceptive
NCT03120533_inc_T28
Person
women
NCT03120533_inc_T29
Value
reproductive
NCT03120533_inc_T30
Person
age
NCT03120533_inc_T31
Scope
women of reproductive age