History of three or more consecutively failed In Vitro Fertilization (IVF) cycles after embryo transfer.
Normal uterine cavity (as assessed by hysteroscopy or HSG).
Normal hormonal investigation: TSH, PRL, FBS.
Normal acquired/inherited thrombophilia profile: LAC, ACA IgG/IgM, Prot S, Antithrombin III, beta-2 glycoprotein, Factors V, II, MTHFR.
Normal semen analysis and mild/moderate male factor (Total motile sperm count > 5 million/ml and/or normal WHO morphology >20%.
Patient provides written informed consent.

NCT02607319_inc_T1
Multiplier
three or more
NCT02607319_inc_T2
Qualifier
consecutively failed
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Procedure
In Vitro Fertilization
NCT02607319_inc_T4
Procedure
IVF
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Temporal
after embryo transfer
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Reference_point
embryo transfer
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Observation
uterine cavity
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Value
Normal
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Procedure
hysteroscopy
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Procedure
HSG
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Scope
hysteroscopy or HSG
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Procedure
hormonal investigation:
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Value
Normal
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Measurement
TSH
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Measurement
PRL
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Measurement
FBS
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Scope
TSH, PRL, FBS
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Measurement
thrombophilia profile
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Value
Normal
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Measurement
LAC
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Measurement
ACA IgG
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Measurement
Prot S
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Measurement
Antithrombin III
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Measurement
 I , P
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Measurement
beta-2 glycoprotein
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Measurement
Factors V
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Measurement
tors V,
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Measurement
MTHFR
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Scope
LAC, ACA IgG/IgM, Prot S, Antithrombin III, beta-2 glycoprotein, Factors V, II, MTHFR
NCT02607319_inc_T30
Measurement
semen analysis
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Condition
male factor
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Qualifier
moderate
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Qualifier
mild
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Scope
mild/moderate
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Measurement
Total motile sperm count
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Value
> 5 million/ml
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Measurement
normal WHO morphology
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Value
>20%
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Scope
Total motile sperm count > 5 million/ml and/or normal WHO morphology >20%