Diagnosis of primary progressive MS
Inability to complete an MRI (contraindications for MRI include but are not restricted to weight =140 kg, pacemaker, cochlear implants, presence of foreign substances in the eye, intracranial vascular clips, surgery within 6 weeks of entry into the study, coronary stent implanted within 8 weeks prior to the time of the intended MRI, etc…)
Gadolinium intolerance
History of ischemic cerebrovascular disorders (e.g., stroke, transient ischemic attack) or ischemia of the spinal cord
History or known presence of central nervous system (CNS) or spinal cord tumor (e.g., meningioma, glioma)
History or known presence of potential metabolic causes of myelopathy (e.g., untreated vitamin B12 deficiency)
History or known presence of infectious causes of myelopathy (e.g., syphilis, Lyme disease, human T-lymphotropic virus 1 (HTLV-1), herpes zoster myelopathy)
History of genetically inherited progressive CNS degenerative disorder (e.g., hereditary paraparesis; MELAS [mitochondrial myopathy, encephalopathy, lactic acidosis, stroke] syndrome)
Neuromyelitis optica
History or known presence of systemic autoimmune disorders potentially causing progressive neurologic disease (e.g., lupus, anti-phospholipid antibody syndrome, Sjogren's syndrome, Behçet's disease, sarcoidosis)
History of severe, clinically significant brain or spinal cord trauma (e.g., cerebral contusion, spinal cord compression)
Vulnerable patients (Patient referred to in Articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French Public Health Code)

NCT03589105_exc_T1
Condition
progressive MS
NCT03589105_exc_T2
Qualifier
primary
NCT03589105_exc_T3
Procedure
MRI
NCT03589105_exc_T4
Mood
Inability to complete
NCT03589105_exc_T5
Condition
contraindications
NCT03589105_exc_T6
Procedure
MRI
NCT03589105_exc_T7
Measurement
weight
NCT03589105_exc_T8
Value
=140 kg
NCT03589105_exc_T9
Device
pacemaker
NCT03589105_exc_T10
Device
cochlear implants
NCT03589105_exc_T11
Device
foreign substances in the eye
NCT03589105_exc_T12
Device
intracranial vascular clips
NCT03589105_exc_T13
Procedure
surgery
NCT03589105_exc_T14
Temporal
within 6 weeks of entry into the study
NCT03589105_exc_T15
Reference_point
entry into the study
NCT03589105_exc_T16
Device
coronary stent
NCT03589105_exc_T17
Procedure
implanted
NCT03589105_exc_T18
Temporal
within 8 weeks prior to the time of the intended MRI
NCT03589105_exc_T19
Reference_point
the time of the intended MRI
NCT03589105_exc_T20
Procedure
MRI
NCT03589105_exc_T21
Mood
intended
NCT03589105_exc_T22
Scope
weight =140 kg, pacemaker, cochlear implants, presence of foreign substances in the eye, intracranial vascular clips, surgery within 6 weeks of entry into the study, coronary stent implanted within 8 weeks prior to the time of the intended MRI
NCT03589105_exc_T23
Scope
contraindications for MRI
NCT03589105_exc_T24
Scope
contraindications for MRI include but are not restricted to weight =140 kg, pacemaker, cochlear implants, presence of foreign substances in the eye, intracranial vascular clips, surgery within 6 weeks of entry into the study, coronary stent implanted within 8 weeks prior to the time of the intended MRI
NCT03589105_exc_T25
Scope
Inability to complete an MRI
NCT03589105_exc_T26
Condition
intolerance
NCT03589105_exc_T27
Drug
Gadolinium
NCT03589105_exc_T28
Condition
ischemic cerebrovascular disorders
NCT03589105_exc_T29
Condition
stroke
NCT03589105_exc_T30
Condition
transient ischemic attack
NCT03589105_exc_T31
Condition
ischemia of the spinal cord
NCT03589105_exc_T32
Scope
stroke, transient ischemic attack
NCT03589105_exc_T33
Condition
ral nervous system (CNS) or r (e.
NCT03589105_exc_T34
Condition
spinal cord tumor
NCT03589105_exc_T35
Condition
meningioma
NCT03589105_exc_T36
Condition
glioma
NCT03589105_exc_T37
Scope
meningioma, glioma
NCT03589105_exc_T38
Scope
central nervous system (CNS) or spinal cord tumo
NCT03589105_exc_T39
Condition
myelopathy
NCT03589105_exc_T40
Condition
metabolic causes
NCT03589105_exc_T41
Condition
vitamin B12 deficiency
NCT03589105_exc_T42
Qualifier
untreated
NCT03589105_exc_T43
Scope
metabolic causes of myelopathy
NCT03589105_exc_T44
Scope
untreated vitamin B12 deficiency
NCT03589105_exc_T45
Condition
infectious causes
NCT03589105_exc_T46
Condition
myelopathy
NCT03589105_exc_T47
Condition
syphilis
NCT03589105_exc_T48
Condition
Lyme disease
NCT03589105_exc_T49
Condition
human T-lymphotropic virus 1 (HTLV-1)
NCT03589105_exc_T50
Condition
herpes zoster myelopathy
NCT03589105_exc_T51
Scope
syphilis, Lyme disease, human T-lymphotropic virus 1 (HTLV-1), herpes zoster myelopathy
NCT03589105_exc_T52
Scope
infectious causes of myelopathy
NCT03589105_exc_T53
Condition
progressive CNS degenerative disorder
NCT03589105_exc_T54
Qualifier
genetically inherited
NCT03589105_exc_T55
Condition
hereditary paraparesis
NCT03589105_exc_T56
Condition
mitochondrial myopathy
NCT03589105_exc_T57
Condition
encephalopathy
NCT03589105_exc_T58
Condition
lactic acidosis
NCT03589105_exc_T59
Condition
stroke
NCT03589105_exc_T60
Condition
mitoc e)
Neuro
NCT03589105_exc_T61
Scope
mitochondrial myopathy, encephalopathy, lactic acidosis, stroke
NCT03589105_exc_T62
Scope
hereditary paraparesis; MELAS [mitochondrial myopathy, encephalopathy, lactic acidosis, stroke] syndrome
NCT03589105_exc_T63
Scope
genetically inherited progressive CNS degenerative disorder
NCT03589105_exc_T64
Condition
Neuromyelitis optica
NCT03589105_exc_T65
Observation
History
NCT03589105_exc_T66
Condition
systemic autoimmune disorders
NCT03589105_exc_T67
Condition
progressive neurologic disease
NCT03589105_exc_T68
Mood
potentially causing
NCT03589105_exc_T69
Condition
lupus
NCT03589105_exc_T70
Condition
anti-phospholipid antibody syndrome
NCT03589105_exc_T71
Condition
Sjogren's syndrome
NCT03589105_exc_T72
Condition
Behçet's disease
NCT03589105_exc_T73
Condition
sarcoidosis
NCT03589105_exc_T74
Scope
lupus, anti-phospholipid antibody syndrome, Sjogren's syndrome, Behçet's disease, sarcoidosis
NCT03589105_exc_T75
Scope
systemic autoimmune disorders potentially causing progressive neurologic disease
NCT03589105_exc_T76
Qualifier
severe
NCT03589105_exc_T77
Qualifier
clinically significant
NCT03589105_exc_T78
Condition
spinal cord trauma
NCT03589105_exc_T79
Condition
pinal g., ce
NCT03589105_exc_T80
Scope
brain or spinal cord trauma
NCT03589105_exc_T81
Condition
cerebral contusion
NCT03589105_exc_T82
Condition
spinal cord compression
NCT03589105_exc_T83
Scope
cerebral contusion, spinal cord compression
NCT03589105_exc_T84
Scope
severe, clinically significant brain or spinal cord trauma
NCT03589105_exc_T85
Observation
Vulnerable patients
NCT03589105_exc_T86
Qualifier
Articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French Public Health Code