Non-compliance with DOTPlus. Alternatively DOT can be done by telephoning patient on a daily basis 5 times a week and having patient annotate taking drug in a log which would be reviewed by clinic staff
History of being treated for tuberculosis in the prior 2 years unless there is DST, including PCR testing, showing sensitivity to rifamycin.
Known hypersensitivity to rifampin or rifabutin.
Liver enzymes greater than 2 times ULN.
Bilirubin greater than 2 times ULN.
Serum creatinine greater than 3 times ULN.
Hemoglobin less than 7.0 gms even if receiving erythropoietin.
Absolute neutrophil count less than 750 cells/mm3 even if receiving G-CSF.
Fasting triglycerides greater than 400 mg/dL.
Fasting cholesterol > 1.6 upper limits of normal.
GI intolerance of tuberculosis medications requiring discontinuation of tuberculosis medications.
Fasting glucose greater 150 mg/dL.
Pregnant women.
Use of one of the prohibited medications
Any condition that the investigators feel could compromise the use of the current medication.
Have a CD4 cell count of 50 cells/mm3or less
Hepatitis B or C infection
Alcohol or illicit drug use, which in the investigators opinion may affect participation in study.

NCT01700790_exc_T1
Condition
Non-compliance
NCT01700790_exc_T2
Procedure
DOTPlus
NCT01700790_exc_T4
Procedure
treated
NCT01700790_exc_T5
Condition
tuberculosis
NCT01700790_exc_T6
Temporal
in the prior 2 years
NCT01700790_exc_T7
Procedure
PCR testing
NCT01700790_exc_T8
Condition
sensitivity
NCT01700790_exc_T9
Drug
rifamycin
NCT01700790_exc_T10
Condition
DST
NCT01700790_exc_T11
Condition
hypersensitivity
NCT01700790_exc_T12
Drug
rifampin
NCT01700790_exc_T13
Drug
rifabutin
NCT01700790_exc_T14
Scope
rifampin or rifabutin
NCT01700790_exc_T15
Measurement
Liver enzymes
NCT01700790_exc_T16
Value
greater than 2 times ULN
NCT01700790_exc_T17
Measurement
Bilirubin
NCT01700790_exc_T18
Value
greater than 2 times ULN
NCT01700790_exc_T19
Measurement
Serum creatinine
NCT01700790_exc_T20
Value
greater than 3 times ULN
NCT01700790_exc_T21
Measurement
Hemoglobin
NCT01700790_exc_T22
Value
less than 7.0 gms
NCT01700790_exc_T23
Qualifier
even if receiving erythropoietin
NCT01700790_exc_T24
Measurement
Absolute neutrophil count
NCT01700790_exc_T25
Value
less than 750 cells/mm3
NCT01700790_exc_T26
Qualifier
even if receiving G-CSF
NCT01700790_exc_T27
Measurement
Fasting triglycerides
NCT01700790_exc_T28
Value
greater than 400 mg/dL
NCT01700790_exc_T29
Measurement
Fasting cholesterol
NCT01700790_exc_T30
Value
> 1.6 upper limits of normal
NCT01700790_exc_T31
Condition
GI intolerance
NCT01700790_exc_T32
Drug
tuberculosis medications
NCT01700790_exc_T33
Drug
tuberculosis medications
NCT01700790_exc_T34
Procedure
discontinuation
NCT01700790_exc_T35
Measurement
Fasting glucose
NCT01700790_exc_T36
Value
greater 150 mg/dL
NCT01700790_exc_T37
Condition
Pregnant
NCT01700790_exc_T38
Person
women
NCT01700790_exc_T41
Measurement
CD4 cell count
NCT01700790_exc_T42
Value
50 cells/mm3or less
NCT01700790_exc_T43
Condition
Hepatitis B
NCT01700790_exc_T44
Condition
 infecti h
NCT01700790_exc_T45
Observation
t drug  i
NCT01700790_exc_T46
Observation
illicit drug use