Cases of rectal tumours below 12cm from anal verge, or locally advanced tumours invading blood vessels, nerves or bone.
Multiple bone metastasis or central nervous system metastasis
Other neoplastic disease in the 5 previous years, except squamous or basal cell skin carcinoma or cervical "in situ" carcinoma
Significant heart disease (chronic congestive heart failure, symptomatic coronary disease) or myocardial infarction in the previous 6 months
Peripheral neuropathy
Patients who do not give informed consent

NCT02015923_exc_T1
Condition
rectal tumours
NCT02015923_exc_T2
Qualifier
below 12cm from anal verge
NCT02015923_exc_T3
Condition
locally advanced tumours
NCT02015923_exc_T4
Condition
invading blood vessels
NCT02015923_exc_T5
Condition
nerves invading
NCT02015923_exc_T6
Condition
bone invading
NCT02015923_exc_T7
Scope
invading blood vessels, nerves or bone
NCT02015923_exc_T8
Condition
Multiple bone metastasis
NCT02015923_exc_T9
Condition
central nervous system metastasis
NCT02015923_exc_T10
Condition
neoplastic disease
NCT02015923_exc_T11
Qualifier
Other
NCT02015923_exc_T12
Temporal
in the 5 previous years
NCT02015923_exc_T13
Condition
basal cell skin carcinoma
NCT02015923_exc_T14
Condition
uamous o ll skin carcinoma o
NCT02015923_exc_T15
Condition
cervical "in situ" carcinoma
NCT02015923_exc_T16
Negation
except
NCT02015923_exc_T17
Scope
squamous or basal cell skin carcinoma or cervical "in situ" carcinoma
NCT02015923_exc_T18
Condition
heart disease
NCT02015923_exc_T19
Qualifier
Significant
NCT02015923_exc_T20
Condition
chronic congestive heart failure
NCT02015923_exc_T21
Condition
symptomatic coronary disease
NCT02015923_exc_T22
Scope
chronic congestive heart failure, symptomatic coronary disease
NCT02015923_exc_T23
Scope
Significant heart disease
NCT02015923_exc_T24
Condition
myocardial infarction
NCT02015923_exc_T25
Temporal
in the previous 6 months
NCT02015923_exc_T26
Condition
Peripheral neuropathy