Type 1 diabetes
Known peripheral artery disease
Liver enzymes equal or more than 1.5 times the upper limit of normal
Chronic heart failure NYHA class III or IV
Current haemodialysis or peritoneal dialysis
End stage liver disease, defined as acute or chronic liver disease and recent history of one of the following: ascites, encephalopathy, variceal bleeding, bilirubin equal or greater than 2.0 mg/dL, albumin equal or less than 3.5 g/ dL, prothrombin time greater or equal to 4 seconds, INR greater than or equal to 1.7 or prior liver transplant
Known or suspected hypersensitivity to trial products or related products
Female of child-bearing potential who is pregnant, breast-feeding or intends to become pregnant or is not using adequate contraceptive methods as required by law or local practice.
Expected simultaneous participation in any other clinical trial of an investigational medicinal product.
Receipt of any investigational medicinal product within 30 days before randomization
Current or past (within the last 5 years) malignant neoplasms (except basal cell and squamous cell skin carcinoma)
Any condition that in the investigator's opinion would make the subject unable to adhere to the trial visit schedule and procedures
Known history of non-compliance to treatment.

NCT02624908_exc_T1
Condition
Type 1 diabetes
NCT02624908_exc_T2
Condition
peripheral artery disease
NCT02624908_exc_T3
Measurement
Liver enzymes
NCT02624908_exc_T4
Value
equal or more than 1.5 times the upper limit of normal
NCT02624908_exc_T5
Measurement
NYHA
NCT02624908_exc_T6
Value
class III or IV
NCT02624908_exc_T7
Condition
Chronic heart failure
NCT02624908_exc_T8
Procedure
haemodialysis
NCT02624908_exc_T9
Procedure
peritoneal dialysis
NCT02624908_exc_T10
Temporal
Current
NCT02624908_exc_T11
Scope
haemodialysis or peritoneal dialysis
NCT02624908_exc_T12
Condition
End stage liver disease
NCT02624908_exc_T13
Condition
chronic liver disease
NCT02624908_exc_T14
Condition
 or   disease an
NCT02624908_exc_T15
Temporal
recent
NCT02624908_exc_T16
Condition
ascites
NCT02624908_exc_T17
Condition
encephalopathy
NCT02624908_exc_T18
Condition
variceal bleeding
NCT02624908_exc_T19
Measurement
bilirubin
NCT02624908_exc_T20
Value
equal or greater than 2.0 mg/dL
NCT02624908_exc_T21
Measurement
albumin
NCT02624908_exc_T22
Value
equal or less than 3.5 g/ dL
NCT02624908_exc_T23
Measurement
prothrombin time
NCT02624908_exc_T24
Value
greater or equal to 4 seconds
NCT02624908_exc_T25
Measurement
INR
NCT02624908_exc_T26
Value
greater than or equal to 1.7
NCT02624908_exc_T27
Temporal
prior
NCT02624908_exc_T28
Procedure
liver transplant
NCT02624908_exc_T29
Scope
ascites, encephalopathy, variceal bleeding, bilirubin equal or greater than 2.0 mg/dL, albumin equal or less than 3.5 g/ dL, prothrombin time greater or equal to 4 seconds, INR greater than or equal to 1.7 or prior liver transplant
NCT02624908_exc_T30
Scope
acute or chronic liver disease and recent history of one of the following: ascites, encephalopathy, variceal bleeding, bilirubin equal or greater than 2.0 mg/dL, albumin equal or less than 3.5 g/ dL, prothrombin time greater or equal to 4 seconds, INR greater than or equal to 1.7 or prior liver transplant
NCT02624908_exc_T31
Condition
hypersensitivity
NCT02624908_exc_T32
Drug
trial products
NCT02624908_exc_T33
Drug
related products
NCT02624908_exc_T34
Scope
trial products or related products
NCT02624908_exc_T35
Mood
suspected
NCT02624908_exc_T36
Mood
Known
NCT02624908_exc_T37
Scope
Known or suspected
NCT02624908_exc_T41
Condition
malignant neoplasms
NCT02624908_exc_T42
Temporal
Current
NCT02624908_exc_T43
Temporal
past
NCT02624908_exc_T44
Temporal
within the last 5 years
NCT02624908_exc_T45
Scope
Current or past (within the last 5 years)
NCT02624908_exc_T46
Condition
 and squa 
Any con
NCT02624908_exc_T47
Condition
squamous cell skin carcinoma
NCT02624908_exc_T48
Negation
except
NCT02624908_exc_T49
Scope
basal cell and squamous cell skin carcinoma