(1)= 45 years old;
(2)A diagnosis or previous diagnosis of essential hypertension, including anyone currently taking antihypertensive drugs; or for those who have not taken antihypertensive drugs within the last 2 weeks, two consecutive examinations were conducted at least one day apart, and both sitting blood pressure (mean value of 3 measurements) met the following criteria: diastolic blood pressure (DBP) =90 mmHg or systolic blood pressure (SBP) =140 mmHg (the second blood pressure was measured at V1);
(3)If a study participant is a woman of childbearing age, she agrees to use a reliable contraceptive method during the trial;
(4)Voluntarily participates and has signed an informed consent form.
(1)Completed MTHFR C677T gene polymorphism detection in run-in period or MTHFR C677T genotype already known in advance;
(2)Exhibited good tolerance to enalapril and good overall medication compliance (>80%) in run-in period or previously exhibited good tolerance and adherence to ACEI drugs in previous medication history.
(3)Voluntarily continues to participate in this study.

NCT03472508_inc_T1
Value
= 45 years
NCT03472508_inc_T2
Person
old
NCT03472508_inc_T3
Temporal
previous
NCT03472508_inc_T4
Mood
diagnosis
NCT03472508_inc_T5
Condition
essential hypertension
NCT03472508_inc_T6
Scope
diagnosis or previous
NCT03472508_inc_T7
Drug
antihypertensive drugs
NCT03472508_inc_T8
Drug
antihypertensive drugs
NCT03472508_inc_T9
Negation
not
NCT03472508_inc_T10
Temporal
within the last 2 weeks
NCT03472508_inc_T11
Multiplier
wo consecutive t least one day apart,
NCT03472508_inc_T12
Procedure
sitting blood pressure
NCT03472508_inc_T13
Measurement
diastolic blood pressure (DBP)
NCT03472508_inc_T14
Value
=90 mmHg
NCT03472508_inc_T15
Measurement
systolic blood pressure (SBP)
NCT03472508_inc_T16
Value
=140 mmHg
NCT03472508_inc_T17
Scope
diastolic blood pressure (DBP) =90 mmHg or systolic blood pressure (SBP) =140 mmHg
NCT03472508_inc_T18
Temporal
currently
NCT03472508_inc_T19
Scope
not taken antihypertensive drugs within the last 2 weeks
NCT03472508_inc_T20
Scope
currently taking antihypertensive drugs
NCT03472508_inc_T21
Scope
two consecutive examinations were conducted at least one day apart, and both sitting blood pressure (mean value of 3 measurements) met the following criteria: diastolic blood pressure (DBP) =90 mmHg or systolic blood pressure (SBP) =140 mmHg
NCT03472508_inc_T23
Person
woman
NCT03472508_inc_T24
Observation
childbearing age
NCT03472508_inc_T25
Scope
woman of childbearing age
NCT03472508_inc_T26
Qualifier
reliable
NCT03472508_inc_T27
Observation
contraceptive method
NCT03472508_inc_T28
Temporal
during the trial
NCT03472508_inc_T29
Reference_point
the trial
NCT03472508_inc_T30
Mood
agrees to use
NCT03472508_inc_T31
Observation
signed an informed consent
NCT03472508_inc_T32
Observation
Voluntarily participates
NCT03472508_inc_T33
Procedure
gene polymorphism detection
NCT03472508_inc_T34
Observation
genotype already known
NCT03472508_inc_T35
Qualifier
MTHFR C677T
NCT03472508_inc_T36
Qualifier
MTHFR C677T
NCT03472508_inc_T37
Condition
good tolerance to enalapril
NCT03472508_inc_T38
Drug
enalapril
NCT03472508_inc_T39
Measurement
overall medication compliance
NCT03472508_inc_T40
Value
good
NCT03472508_inc_T41
Value
>80%
NCT03472508_inc_T42
Temporal
previously
NCT03472508_inc_T43
Condition
tolerance and EI drugs in p
NCT03472508_inc_T44
Drug
ACEI drugs
NCT03472508_inc_T45
Observation
tole ence to ACEI drugs in p
NCT03472508_inc_T46
Observation
medication history
NCT03472508_inc_T47
Scope
good tolerance and adherence to ACEI drugs
NCT03472508_inc_T48
Scope
good tolerance to enalapril and good overall medication compliance (>80%) in run-in period
NCT03472508_inc_T49
Observation
continues to participate in this study
NCT03472508_inc_T50
Qualifier
Voluntarily