Not available for follow-up
Pregnant or breast-feeding
Chronic pain syndrome defined as use of any analgesic medication on a daily or near-daily basis
Allergic to or intolerant of investigational medications
Contra-indications to non-steroidal anti-inflammatory drugs: 1) history of hypersensitivity to NSAIDs or aspirin 2) active or history of peptic ulcer disease, chronic dyspepsia, or active or history of gastrointestinal bleed 3) Severe heart failure (NYHA 2 or worse) 4) hypertension (JNC7 stage 2 or worse) 5) Chronic kidney disease 3 or worse 6) Current use of anti-coagulants 7) Hepatitis 8) Alcoholism
Contra-indications to muscle relaxants: 1) Concurrent use of centrally acting opioids; 2) Renal impairment; 3) Liver abnormality including cirrhosis or elevated enzymes 4) Use of any of the following medications: fluvoxamine, fluoroquinolones, amiodarone, mexiletine, propafenone, verapamil, cimetidine, famotidine, acyclovir, ticlopidine, oral contraceptive pills

NCT03068897_exc_T2
Condition
Pregnant
NCT03068897_exc_T3
Condition
breast-feeding
NCT03068897_exc_T4
Condition
Chronic pain syndrome
NCT03068897_exc_T5
Drug
analgesic medication
NCT03068897_exc_T6
Qualifier
any
NCT03068897_exc_T7
Multiplier
on a daily basis
NCT03068897_exc_T8
Multiplier
on a near-daily basis
NCT03068897_exc_T11
Condition
Allergic
NCT03068897_exc_T12
Condition
intolerant
NCT03068897_exc_T13
Drug
investigational medications
NCT03068897_exc_T15
Condition
Contra-indications
NCT03068897_exc_T16
Drug
non-steroidal anti-inflammatory drugs
NCT03068897_exc_T17
Condition
hypersensitivity
NCT03068897_exc_T18
Drug
NSAIDs
NCT03068897_exc_T19
Drug
aspirin
NCT03068897_exc_T21
Temporal
history
NCT03068897_exc_T22
Temporal
active
NCT03068897_exc_T23
Temporal
history
NCT03068897_exc_T24
Condition
peptic ulcer disease
NCT03068897_exc_T25
Condition
chronic dyspepsia
NCT03068897_exc_T26
Temporal
active
NCT03068897_exc_T27
Temporal
history
NCT03068897_exc_T28
Condition
gastrointestinal bleed
NCT03068897_exc_T32
Qualifier
Severe
NCT03068897_exc_T33
Condition
heart failure
NCT03068897_exc_T34
Measurement
NYHA
NCT03068897_exc_T35
Value
2 or worse
NCT03068897_exc_T37
Condition
hypertension
NCT03068897_exc_T38
Measurement
JNC7 stage
NCT03068897_exc_T39
Value
2 or worse
NCT03068897_exc_T40
Condition
Chronic kidney disease
NCT03068897_exc_T41
Temporal
Current
NCT03068897_exc_T42
Drug
anti-coagulants
NCT03068897_exc_T43
Condition
Hepatitis
NCT03068897_exc_T44
Condition
Alcoholism
NCT03068897_exc_T48
Condition
Contra-indications
NCT03068897_exc_T49
Drug
muscle relaxants
NCT03068897_exc_T50
Temporal
Concurrent
NCT03068897_exc_T51
Drug
centrally acting opioids
NCT03068897_exc_T52
Condition
Renal impairment
NCT03068897_exc_T53
Condition
Liver abnormality
NCT03068897_exc_T54
Condition
cirrhosis
NCT03068897_exc_T55
Condition
elevated enzymes
NCT03068897_exc_T57
Drug
fluvoxamine
NCT03068897_exc_T58
Drug
fluoroquinolones
NCT03068897_exc_T59
Drug
amiodarone
NCT03068897_exc_T60
Drug
mexiletine
NCT03068897_exc_T61
Drug
propafenone
NCT03068897_exc_T62
Drug
verapamil
NCT03068897_exc_T63
Drug
cimetidine
NCT03068897_exc_T64
Drug
famotidine
NCT03068897_exc_T65
Drug
acyclovir
NCT03068897_exc_T66
Drug
ticlopidine
NCT03068897_exc_T67
Drug
oral contraceptive pills